Primarily colonizes the gingival crevice, but also found in head, neck, abdominal, and lung infections. Has been isolated from blood.
Although commonly detected in subgingival plaque, P. intermedia has been associated with periodontal disease [2], aggressive periodontitis, necrotizing ulcerative periondontis, endodontic infections [4], and facial gangrene (noma) [5]. Has also been linked to coronary artery disease [3].