"gene_id","gene_start","gene_stop","gene_length","gene_nuc_seq","pI","net_charge","mol_wt","gene_prot_seq","defline","comment","definition","cellular_location","blast_summary","interpro_summary","cogs_summary","blocks_summary","ProDom","gene_id_lmd","gene_start_lmd","gene_stop_lmd","gene_length_lmd","gene_nuc_seq_lmd","pI_lmd","net_charge_lmd","mol_wt_lmd","gene_prot_seq_lmd","defline_lmd","comment_lmd","definition_lmd","blast_summary_lmd","cogs_summary_lmd","blocks_summary_lmd","ProDom_lmd","revisit","revisit_lmd","paralog","paralog_lmd","pdb_hit_lmd","pdb_hit","bgene_id","bgene_id_lmd","pfam_summary","pfam_summary_lmd","gi","gi_lmd","case1","case2","case1_lmd","case2_lmd","mol_id","mol_id_lmd","island_id","genbank_locus_tag","dog_id" "SMu0001","194","1552","1359","ATGACAGAAAATGAACAAATTTTTTGGAATAGGGTTTTAGAACTTGCACAAAGTCAATTAAAGCAAGCGACATTTGATTTTTTCGTTTCAGATGCTAAATTATTGAAAGTTGAAGGAAATATTGCGACTATCCTTCTTGATGATATGAAAAAATTATTTTGGGAAAAAAATTTACAGCCTGTTGTTCTAACAGCTGGATTCGAGGTCTTTAATACAGAAATTTCAATTGAGTATGTTTTTGAAGAAACTCAATCCACATCAAACAGCCCACAAATTTCTCAGAATAAAACTGCAGAACTTGCAACAGAAACACTTCCTTTTGTGCAAAATGATCTTAATCCAAAATATAGTTTTGATAACTTTGTGATTGGTGATGAAAATCGTTGGGCTTTTACAGCATCCGTTTCTGTTGCAGACCTTCCTGGAACAACCTATAATCCTCTCTTTATTTATGGAGGACCCGGTTTAGGAAAGACCCACCTTCTAAATGCCATTGGTAACTCTGTTTTAGCAAGCAATCCTAAAGCTCGTATAAAATATATTTCTGCCGAAAATTTTATTAATGAATTTGTTGTCCACATTAGACTACAAAATATGGATGAGCTAAAGAAGAAATTTCGAAATTTAGATTTACTATTAATTGATGATATTCAATCTTTAGCCAAAAAAAGTTTAGCTGCCACTCAAGAAGAATTTTTCAACACCTTTAATGCTTTACATGATAATAATAAGCAGATTGTCCTTACCAGTGATCGAACACCAGATGACCTTAACGATCTTGAGCAACGTTTGGTAACACGTTTTAAATGGGGGTTAACTGTTAACATTACACCTCCTGACTTTGAAACACGAGTAGCTATTTTAAACAATAAAATTCAAGAATATAATTATAGTTTTCTCTCTGAAACAATTGAATACTTAGCTGGACAGTTCGACTCCAACGTCCGTGATCTAGAAGGTGCCCTAAAAGATATCAGTCTTGTGGCTAATTTTAAAAAACTTGATGTTATTACTGTTGAAGTTGCAGCAGAAGCTATCAGGGCAAGAAAGCAAGATAGCAGTCCTAAGATGATTGTTATCCCTATTGAAGATATCCAAAAACAGGTTGGAAAATTTTATGGCGTAACTGTTAAAGAAATCAAATCAACCAAGAGAACACAAAACATTGTTTTAGCACGCCAAGTTGGCATGTATTTAGCACGTGAAATGACAGATAACAGTCTTCCAAAAATCGGAAAGGAATTTGGAGGGCGAGATCATTCAACCGTTCTACATGCCTATAATAAAATCAAAAATATGTTAGCACAGGATGACAGTCTAAAAATAGAAATGGAAACGATTAAAAATAAGATAAAATAA","5.50","-5.75","51359","MTENEQIFWNRVLELAQSQLKQATFDFFVSDAKLLKVEGNIATILLDDMKKLFWEKNLQPVVLTAGFEVFNTEISIEYVFEETQSTSNSPQISQNKTAELATETLPFVQNDLNPKYSFDNFVIGDENRWAFTASVSVADLPGTTYNPLFIYGGPGLGKTHLLNAIGNSVLASNPKARIKYISAENFINEFVVHIRLQNMDELKKKFRNLDLLLIDDIQSLAKKSLAATQEEFFNTFNALHDNNKQIVLTSDRTPDDLNDLEQRLVTRFKWGLTVNITPPDFETRVAILNNKIQEYNYSFLSETIEYLAGQFDSNVRDLEGALKDISLVANFKKLDVITVEVAAEAIRARKQDSSPKMIVIPIEDIQKQVGKFYGVTVKEIKSTKRTQNIVLARQVGMYLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMLAQDDSLKIEMETIKNKIK","1549","For other 'dna' genes, see SMu0002 (dnaN); SMu0074 (dnaK); SMu0075 (dnaJ); SMu0745 (dnaG); SMu1091 (dnaE); SMu1745 (dnaI); SMu1746 (dnaB); SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC).","chromosomal replication initiator protein DnaA","Cytoplasm","Several matches in gapped BLAST to dnaA proteins: residues 1-452 are 80% similar to the enzyme in S.pyogenes (gi15674251). Residues 5-452 are 59% similar to the protein from S.pneumoniae (gi15902045).See Spy0002, Sag0001, Str0001.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0001 (0.0).","

InterPro
IPR001957
Family

Bacterial chromosomal replication initiator protein, DnaA
PR00051	$\"[145-165]T$ $\"[177-191]T$ $\"[209-223]T$ $\"[245-272]T$ $\"[411-430]T$	DNAA
TIGR00362	$\"[2-451]T$	DnaA
PS01008	$\"[411-430]T$	DNAA

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[144-277]T$	AAA

InterPro
IPR010921
Domain

Trp repressor/replication initiator
SSF48295	$\"[360-452]T$	Trp_repress_rep

InterPro
IPR013159
Domain

Chromosomal replication initiator, DnaA C-terminal
PF08299	$\"[361-430]T$	Bac_DnaA_C
SM00760	$\"[361-430]T$	Bac_DnaA_C

InterPro
IPR013317
Domain

Chromosomal replication initiator, DnaA
PF00308	$\"[112-332]T$	Bac_DnaA

noIPR
unintegrated

unintegrated
G3DSA:1.10.1750.10	$\"[348-451]T$	G3DSA:1.10.1750.10
G3DSA:3.40.50.300	$\"[109-278]T$	G3DSA:3.40.50.300
PTHR13779	$\"[117-222]T$	PTHR13779
SSF52540	$\"[110-328]T$	SSF52540

","BeTs to 12 clades of COG0593COG name: ATPase involved in DNA replication initiationFunctional Class: LThe phylogenetic pattern of COG0593 is -----qvcEbrHujgpolINXNumber of proteins in this genome belonging to this COG is 1","***** IPB001957 (Bacterial chromosomal replication initiator protein, DnaA) with a combined E-value of 2.1e-92. IPB001957A 145-162 IPB001957B 204-250 IPB001957C 261-292 IPB001957D 379-430 IPB001957B 202-248 IPB001957B 203-249","Residues 145-255 are 80% similar to a (REPLICATION ATP-BINDING DNA-BINDING INITIATOR) protein domain (PD066439) which is seen in DNAA_STRPY.Residues 5-80 are 76% similar to a (REPLICATION CHROMOSOMAL DNA-BINDING) protein domain (PD173795) which is seen in DNAA_STRPY.Residues 257-430 are 67% similar to a (REPLICATION ATP-BINDING DNA-BINDING INITIATOR) protein domain (PD002717) which is seen in DNAA_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Jul 1 07:09:21 2006","Sat Jul 1 07:09:21 2006","Sat Jul 1 07:09:21 2006","Wed Dec 5 07:57:38 2001","Wed Dec 5 07:57:38 2001","Wed Dec 5 07:57:38 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0001 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 13:25:33 2002","","No significant hits to the NCBI PDB database.","SMU.01","Fri Nov 30 10:23:25 2001","Residues 112 to 430 (E-value = 4.9e-159) place SMu0001 in the Bac_DnaA family which is described as Bacterial dnaA protein (PF00308)","Wed Dec 5 07:57:38 2001","24378533","","","Suvorov,A.N. and Ferretti,J.J.Replication origin of Streptococcus pyogenes, organization andcloning in heterologous systemsFEMS Microbiol. Lett. 189 (2), 293-297 (2000)PubMed: 10930754Hansen,E.B., Hansen,F.G. and von Meyenburg,K.The nucleotide sequence of the dnaA gene and the first part of thednaN gene of Escherichia coli K-12Nucleic Acids Res. 10 (22), 7373-7385 (1982)PubMed: 6296774 Ohmori,H., Kimura,M., Nagata,T. and Sakakibara,Y.Structural analysis of the dnaA and dnaN genes of Escherichia coliGene 28 (2), 159-170 (1984)PubMed: 6234204Ogura Y, Imai Y, Ogasawara N, Moriya S.Autoregulation of the dnaA-dnaN operon and effects of DnaA protein levels on replication initiation in Bacillus subtilis.J Bacteriol. 2001 Jul;183(13):3833-41.PMID: 11395445","","Wed Dec 5 07:57:38 2001","1","","","SMU.01","1" "SMu0002","1708","2844","1137","ATGATAAAATTTTCAATTAATAAAGTTTTTTTCTTACAAGCCTTAAATGCTACCAAGCGAGCTATTAGTTCTAAAAATGCTATTCCTATTCTTTCTAGTTTAAAAATTGAAGTGAATTCTCAGTCCATTACTTTAACAGGCTCTAATGGACAAATTTCTATTGAAAATACGATTTCAGCTGAAGAAGAAAATGCTGGACTATTGGTTACTTCTTCAGGAGCTATCTTACTTGAAGCTAATTTCTTTATTAATATTGTTTCAAGCCTACCTGATATCACTTTAGATTTTGAAGAAATTGAACAACATCAAGTTGTTTTAAATAGTGGAAAATCAGAAATTACACTTAAAGGTAAAGATGTGGAACAATATCCTCGTTTGCAGGAAGTTGGAACAAATAATCCTTTAATTTTAGAAACAAAATTGTTAAAAACAATTATTTCTGAAACAGCTTTTGCTGCTAGTACCCAAGAAAGTCGACCAATTTTAACAGGTGTTCATTTGGTATTGACAAATCATAAAGAGTTTAAAGCTGTTGCTACAGACTCTCATCGCATGAGTCAAAGAAAATTAACTCTTGACCATTCATCAGATGATTTTGATGTCGTCATTCCAAGCCGTTCTTTACGTGAATTTGCAGCTGTATTTACAGATGATATTGAATCTGTTGAGGTATTTTTCTCTAACAGTCAAATCCTCTTTAGAAGTGAATATATTAGCTTCTATACGCGCCTGTTAGAAGGAAATTATCCTGATACTGATCGCTTGTTGGGCAATAACTTTGAAACAGAAGTTGTCTTCAATACTAATGCTCTTCGTTATGCTATGGAGCGTGCTCATTTAATCTCAAATGCTACCCAAAATGGTACTGTTAAATTGGAGATTATCAACAATCAAGTAACAGCACATGTTAATTCACCTGAGGTTGGAAAAGTCAATGAAGAACTTGATATTGAAAGCTTATCAGGAAATGATTTAACAATAAGCTTTAACCCAACTTACTTGATCGAAGCTTTAAAAGCTCTTAAAAGTGAGACTGTCACAATTCGTTTTATTTCCCCAATTCGCCCTTTCACTTTAACACCGAGTGATAACAGTGAAAACTTCATTCAATTGATTACACCTGTTCGCACAAACTAA","4.80","-13.28","42062","MIKFSINKVFFLQALNATKRAISSKNAIPILSSLKIEVNSQSITLTGSNGQISIENTISAEEENAGLLVTSSGAILLEANFFINIVSSLPDITLDFEEIEQHQVVLNSGKSEITLKGKDVEQYPRLQEVGTNNPLILETKLLKTIISETAFAASTQESRPILTGVHLVLTNHKEFKAVATDSHRMSQRKLTLDHSSDDFDVVIPSRSLREFAAVFTDDIESVEVFFSNSQILFRSEYISFYTRLLEGNYPDTDRLLGNNFETEVVFNTNALRYAMERAHLISNATQNGTVKLEIINNQVTAHVNSPEVGKVNEELDIESLSGNDLTISFNPTYLIEALKALKSETVTIRFISPIRPFTLTPSDNSENFIQLITPVRTN","2841","For other 'dna' genes, see SMu0001 (dnaA); SMu0074 (dnaK); SMu0075 (dnaJ);SMu0745 (dnaG); SMu1091 (dnaE); SMu1745 (dnaI); SMu1746 (dnaB);SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC). For DNA polymerase III, alpha subunit see SMu0110.For DNA polymerase III subunits gamma / tau see SMu1437.For DNA polymerase III, delta prime subunit see SMu1514.","DNA polymerase III, beta subunit","Cytoplasm, Membrane","Matches in gapped BLAST to polIII beta subunits: residues 1-378 are 80% similar to the enzyme in S.pyogenes (gi15674252) and are 75% similar to the enzyme in S.pneumoniae (gi15899951).See Spy0003.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0002 (1e-161).","

InterPro
IPR001001
Family

DNA polymerase III, beta chain
G3DSA:3.10.150.10	$\"[2-130]T$ $\"[131-255]T$ $\"[257-376]T$	DNA_polIII_beta
PF00712	$\"[2-127]T$	DNA_pol3_beta
PF02767	$\"[136-251]T$	DNA_pol3_beta_2
PF02768	$\"[253-376]T$	DNA_pol3_beta_3
SM00480	$\"[18-373]T$	POL3Bc
TIGR00663	$\"[2-377]T$	dnan

noIPR
unintegrated

unintegrated
SSF55979	$\"[2-129]T$ $\"[130-252]T$ $\"[253-377]T$	SSF55979

","BeTs to 12 clades of COG0592COG name: DNA polymerase III beta subunitFunctional Class: LThe phylogenetic pattern of COG0592 is amtKyqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001001 (DNA polymerase III, beta chain) with a combined E-value of 2.9e-60. IPB001001A 6-54 IPB001001B 73-87 IPB001001C 106-124 IPB001001D 142-165 IPB001001E 177-187 IPB001001F 201-211 IPB001001G 242-257 IPB001001H 322-341","Residues 153-376 are 74% similar to a (DNA POLYMERASE III BETA) protein domain (PD373027) which is seen in DP3B_STRPN.Residues 2-131 are 27% similar to a (DNA POLYMERASE III BETA) protein domain (PD343696) which is seen in DP3B_MYCPA.Residues 167-349 are 20% similar to a (III PROTEOME BETA CHAIN) protein domain (PD400877) which is seen in Q9PR66_UREPA.Residues 156-376 are 26% similar to a (DNA POLYMERASE III BETA) protein domain (PD003062) which is seen in Q9PHE2_XYLFA.Residues 2-134 are 73% similar to a (DNA POLYMERASE III BETA) protein domain (PD328536) which is seen in DP3B_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 3 08:37:34 2006","Fri Nov 30 10:43:04 2001","Fri Feb 3 08:37:34 2006","Thu Mar 28 08:26:55 2002","Thu Feb 7 10:15:39 2002","Thu Feb 7 10:15:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0002 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 08:26:55 2002","Fri Feb 3 08:37:34 2006","pdb2POLA Chain A, Pol Iii (Beta Subunit) (E.C.2.7.7.7) >gi49... 530 8e-152","SMU.02","Fri Nov 30 10:43:04 2001","Residues 2 to 127 (E-value = 1.4e-24) place SMu0002 in the DNA_pol3_beta family which is described as DNA polymerase III beta subunit, N-terminal domain (PF00712)Residues 136 to 251 (E-value = 9.6e-35) place SMu0002 in the DNA_pol3_beta_2 family which is described as DNA polymerase III beta subunit, central domain (PF02767)Residues 253 to 376 (E-value = 4.5e-31) place SMu0002 in the DNA_pol3_beta_3 family which is described as DNA polymerase III beta subunit, C-terminal domain (PF02768)","Fri Feb 3 08:37:34 2006","24378534","","","Ohmori,H., Kimura,M., Nagata,T. and Sakakibara,Y.Structural analysis of the dnaA and dnaN genes of Escherichia coliGene. 28 (2), 159-170 (1984)PubMed: 6234204Armengod,M.E. and Lambies,E.Overlapping arrangement of the recF and dnaN operons of Escherichia coli; positive and negative control sequencesGene. 43 (3), 183-196 (1986)PubMed: 3527871 Blanar,M.A., Sandler,S.J., Armengod,M.E., Ream,L.W. and Clark,A.J.Molecular analysis of the recF gene of Escherichia coliProceedings of the National Academy of Sciences of the UnitedStates of America. 81 (15), 4622-4626 (1984)PubMed: 6379647 Adachi,T., Mizuuchi,K., Menzel,R. and Gellert,M.DNA sequence and transcription of the region upstream of the E. coli gyrB geneNucleic acids research. 12 (16), 6389-6395 (1984)PubMed: 6089112 Kong,X.P., Onrust,R., O'Donnell,M. and Kuriyan,J.Three-dimensional structure of the beta subunit of E. coli DNApolymerase III holoenzyme: a sliding DNA clampCell. 69 (3), 425-437 (1992)PubMed: 1349852 O'Donnell,M.Accessory protein function in the DNA polymerase III holoenzymefrom E. coliBioEssays : news and reviews in molecular, cellular anddevelopmental biology. 14 (2), 105-111 (1992)PubMed: 1575709Ogura Y, Imai Y, Ogasawara N, Moriya S.Autoregulation of the dnaA-dnaN operon and effects of DnaA protein levels on replication initiation in Bacillus subtilis.J Bacteriol. 2001 Jul;183(13):3833-41.PMID: 11395445","","Fri Feb 3 08:37:34 2006","1","","","SMU.02","212" "SMu0003","3106","3297","192","ATGTACGAATTAGGATCTTTAGTTGAAATGAAAAAGCCCCATGCCTGCACCATTAAGACGACAGGTAAAAAAGCCAATTGTTGGGAGGTCGTACGTATCGGTGCTGACATCAAAATCAAATGCACCAACTGTGATCATGTGGTCATGATGAGCCGCCATGATTTTGAACGTAAGATAAAAAAGGTTTTATAA","9.90","6.51","7247","MYELGSLVEMKKPHACTIKTTGKKANCWEVVRIGADIKIKCTNCDHVVMMSRHDFERKIKKVL","3294","","conserved hypothetical protein","Periplasm, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-63 are 77% similar to S.pyogenes (gi15674253 ) and 73% similar to S.pneumoniae (gi15902047).See Spy0004.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0004 (6e-28).","

InterPro
IPR009296
Family

Protein of unknown function DUF951, bacterial
PF06107	$\"[1-63]T$	DUF951

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-63 are 72% similar to a (PROTEOME COMPLETE BH4052 TRNA-ARG) protein domain (PD053627) which is seen in O06673_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 3 08:36:13 2006","Fri Nov 30 13:43:23 2001","Fri Feb 3 08:36:13 2006","Mon Oct 7 13:37:32 2002","","Mon Oct 7 13:37:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0003 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 3 08:36:13 2006","","No significant hits to the NCBI PDB database.","SMU.05","Fri Nov 30 13:43:23 2001","Residues 1 to 63 (E-value = 5.6e-44) place SMu0003 in the DUF951 family which is described as Bacterial protein of unknown function (DUF951) (PF06107)","Mon Oct 7 13:37:32 2002","24378535","","","","","","1","","","SMU.05","870" "SMu0004","3461","4576","1116","ATGGCTTTAACAGCAGGTATCGTTGGTTTGCCTAATGTTGGAAAATCAACGCTTTTTAATGCAATAACAAAGGCAGGAGCAGAAGCTGCCAACTATCCTTTTGCAACGATTGATCCTAATGTGGGTATGGTTGAAGTACCAGATATACGTTTACAGAAGTTGACAGAACTTATTGTACCTAAAAAGACTGTGCCAACAACGTTTGAGTTTACAGATATTGCAGGTATTGTCAAGGGAGCGTCAAAGGGTGAAGGTCTTGGAAATAAATTTTTAGCCAATATTCGTGAAATAGATGCTATTGTTCATGTTGTACGTGCTTTCAATGATGAAAATGTTATGCGTGAACAAGGACGTGAATCTGATTTTGTTGATCCAATAGCCGATATTGAAACTATTAATTTAGAATTAATTTTGGCAGATCTTGAGTCTATTAATAAGCGCTATGCGCGTGTAGAAAAAATTGCACGTACGCAAAAAGATAAGGATTCTGTAGCCGAGTTTAACATTCTTCAAAAGATAAAACCTGTTCTTGAAGATGGAAAGTCAGCACGTACCATTGATTTTACAGAAGATGAAGCAAAAATTGTCAAAGGCTTGTTCTTATTGACAACTAAACCAGTACTTTATGTAGCCAATGTTGATGAAGATAAAGTAGCTGATCCAGATAGTATTGATTATGTTCAACAAATCCGTGAATTTGCAGCAACGGAAAATGCTGAAGTTGTTGTTATTTCAGCGCGTGCTGAAGAAGAAATTTCTGAACTTGATGATGAAGATAGAGCAGAGTTTTTAGAAGCAATGGGCTTAAATGAATCAGGCGTTGATAAATTGACACGGGCAGCTTATCATTTGTTGGGTCTTGGAACTTACTTTACAGCTGGTGAAAAAGAAGTGCGTGCTTGGACCTTTAAACGTGGAATCAAAGCACCACAAGCTGCAGGAATTATCCATTCAGATTTTGAAAAAGGCTTCATCCGTGCTGTAACCATGTCTTATGATGATCTTATAAAATATGGCTCTGAAAAAGCTGTAAAAGAAGCAGGTCGCCTACGTGAAGAAGGTAAAGATTATATTGTTCAAGATGGTGATATTATGGAATTCCGATTCAATGTTTAA","4.60","-18.22","41074","MALTAGIVGLPNVGKSTLFNAITKAGAEAANYPFATIDPNVGMVEVPDIRLQKLTELIVPKKTVPTTFEFTDIAGIVKGASKGEGLGNKFLANIREIDAIVHVVRAFNDENVMREQGRESDFVDPIADIETINLELILADLESINKRYARVEKIARTQKDKDSVAEFNILQKIKPVLEDGKSARTIDFTEDEAKIVKGLFLLTTKPVLYVANVDEDKVADPDSIDYVQQIREFAATENAEVVVISARAEEEISELDDEDRAEFLEAMGLNESGVDKLTRAAYHLLGLGTYFTAGEKEVRAWTFKRGIKAPQAAGIIHSDFEKGFIRAVTMSYDDLIKYGSEKAVKEAGRLREEGKDYIVQDGDIMEFRFNV","4573","","uncharacterized GTP-binding protein","Cytoplasm","Matches in gapped BLAST to GTP-binding proteins: residues 1-371 are 93% similar to gi15674254 in S.pyogenes and 91% similar to a conserved hypothetical protein in S.pneumoniae (gi15902048).This sequence is weakly similar to a fragment of the previously sequenced phosphoglycerate dehydrogenase from S.mutans (BAA88823)See SMu1744.This sequence corresponds to Spy0006.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0006 (0.0).","

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[3-160]T$	MMR_HSR1

InterPro
IPR004396
Family

Conserved hypothetical protein 92
TIGR00092	$\"[1-371]T$	CHP92

InterPro
IPR006073
Domain

GTP1/OBG
PR00326	$\"[5-25]T$ $\"[26-44]T$ $\"[70-85]T$ $\"[87-105]T$	GTP1OBG

InterPro
IPR012675
Domain

Beta-grasp fold, ferredoxin-type
G3DSA:3.10.20.30	$\"[287-371]T$	Ferredoxin_fold

InterPro
IPR012676
Domain

TGS-like
SSF81271	$\"[287-371]T$	TGS-like

InterPro
IPR013029
Domain

Protein of unknown function DUF933
PF06071	$\"[287-370]T$	DUF933

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-286]T$	G3DSA:3.40.50.300
PTHR23305	$\"[1-371]T$	PTHR23305
PTHR23305:SF4	$\"[1-371]T$	PTHR23305:SF4
SSF52540	$\"[1-286]T$	SSF52540

","BeTs to 17 clades of COG0012COG name: Predicted GTPaseFunctional Class: RThe phylogenetic pattern of COG0012 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000765 (GTP1/OBG family) with a combined E-value of 5.6e-26. IPB000765 3-46","Residues 3-47 are 63% similar to a (GTP-BINDING SCO2-MRF1 CHROMOSOME YLF2) protein domain (PD406352) which is seen in O13998_SCHPO.Residues 230-269 are 55% similar to a (GTP-BINDING PROTEOME COMPLETE RPSF-SPO0J) protein domain (PD409901) which is seen in YYAF_BACSU.Residues 244-368 are 86% similar to a (GTP-BINDING COMPLETE PROTEOME MG024) protein domain (PD004355) which is seen in Q9CJI7_LACLA.Residues 69-282 are 25% similar to a (GTP-BINDING COMPLETE PROTEOME HOMOLOG) protein domain (PD186802) which is seen in Q58728_METJA.Residues 1-51 are 98% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9CJI7_LACLA.Residues 108-184 are 81% similar to a (GTP-BINDING PROTEOME COMPLETE) protein domain (PD208342) which is seen in Q9CJI7_LACLA.Residues 54-107 are 92% similar to a (GTP-BINDING PROTEOME COMPLETE) protein domain (PD001145) which is seen in Q9CJI7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 12:17:19 2002","Fri Nov 30 11:37:18 2001","Fri Feb 3 08:34:47 2006","Fri Feb 3 08:34:47 2006","Wed Jan 9 12:16:00 2002","Wed Jan 9 12:16:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0004 is paralogously related (blast p-value < 1e-3) to SMu0727, SMu0519, and SMu1343, all GTP-binding proteins.","Wed Jan 9 12:17:19 2002","","No significant hits to the NCBI PDB database.","SMU.06","Fri Nov 30 11:37:18 2001","Residues 128 to 371 (E-value = 5e-165) place SMu0004 in the DUF933 family which is described as Protein of unknown function (DUF933) (PF06071)","Wed Jan 9 12:16:00 2002","24378536","","","","","","1","","","SMU.06","2" "SMu0005","4663","5232","570","ATGACTAAATTAATTGTTGGCCTTGGAAATCCAGGCAGTAAATATCATGAAACGAAACATAATGTTGGCTTTATGGCTCTTGACAGAATTGTCAAGCCTTTGAATGTTCAGTTTACAGAAAATAAAACATTTAAAGCAGAAACAGTAGCGACTTTTATTAATGGTGAAAAAATTTATTTTATTAAACCAACTACATTTATGAATGCCAGTGGTTTAGCTGTCAGAGCTTTTCTAGCTTATTATAATTTAACTGTGGAAGATCTAATTGTTATTTATGATGATCTTGATATGGAAGTAGGAAAAATACGTTTTCGTCAAAAAGGCTCTGCTGGTGGACATAATGGTATAAAAAGCATTATCAAGGAAATTGGGACTCAGGAATTTGATCGTATCAAGATTGGTATTGGCCGTCCAAAGGATAAGATGACAGTCGTTAACTATGTTTTAGGAAAATTTGATAAAAAAGATGAAATAACTATTTTTAACACACTTGATAAAGTTGACAAAGCTGTCAATTACTATTTACAAACGAAAAATTTTGAACAAACAATGCAAAAATTTAATGGGTAA","10.20","7.72","21462","MTKLIVGLGNPGSKYHETKHNVGFMALDRIVKPLNVQFTENKTFKAETVATFINGEKIYFIKPTTFMNASGLAVRAFLAYYNLTVEDLIVIYDDLDMEVGKIRFRQKGSAGGHNGIKSIIKEIGTQEFDRIKIGIGRPKDKMTVVNYVLGKFDKKDEITIFNTLDKVDKAVNYYLQTKNFEQTMQKFNG","5229","","peptidyl-tRNA hydrolase","Cytoplasm","This sequence corresponds to Spy0007.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0007 (3e-86).","

InterPro
IPR001328
Family

Peptidyl-tRNA hydrolase
PD005324	$\"[70-135]T$	PeptRNAhydrolase
G3DSA:3.40.50.1470	$\"[4-188]T$	Pept_tRNA_hydro
PTHR17224	$\"[1-189]T$	Pept_tRNA_hydro
PF01195	$\"[4-188]T$	Pept_tRNA_hydro
TIGR00447	$\"[2-189]T$	pth
PS01195	$\"[15-28]T$	PEPT_TRNA_HYDROL_1
PS01196	$\"[109-119]T$	PEPT_TRNA_HYDROL_2
SSF53178	$\"[1-188]T$	Pept_tRNA_hydro

","BeTs to 13 clades of COG0193COG name: Peptidyl-tRNA hydrolaseFunctional Class: JThe phylogenetic pattern of COG0193 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001328 (Peptidyl-tRNA hydrolase) with a combined E-value of 1.8e-48. IPB001328A 4-23 IPB001328B 60-71 IPB001328C 88-119 IPB001328D 128-138","Residues 1-188 are 55% similar to a (HYDROLASE PEPTIDYL-TRNA SPORULATION) protein domain (PD005324) which is seen in PTH_LACLA.","","","","","Fri Nov 30 14:56:18 2001","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","Fri Nov 30 14:56:18 2001","","Mon Oct 7 13:44:28 2002","Thu Apr 25 10:33:42 2002","Fri Feb 3 08:33:30 2006","Thu Apr 25 10:33:42 2002","Thu Apr 25 10:33:42 2002","Thu Apr 25 10:33:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0005 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 13:44:28 2002","Fri Feb 3 08:33:30 2006","pdb2PTH Peptidyl-Trna Hydrolase From Escherichia Coli 131 9e-032pdb2PTH Peptidyl-Trna Hydrolase From Escherichia Coli 293 8e-081","SMU.07","Fri Nov 30 12:32:03 2001","Residues 4 to 188 (E-value = 2.1e-77) place SMu0005 in the Pept_tRNA_hydro family which is described as Peptidyl-tRNA hydrolase (PF01195)","Thu Apr 25 10:33:42 2002","24378537","","","","","","1","","1","SMU.07","609" "SMu0006","5234","8722","3489","ATGAATTTAATAGATTTATTTAAACAAAATCAAAAAATTAAAGAGTGGACAGAACATCTCTCTGCTCCTACTAGACAATTAGTAATGGGATTTTCAAGCTCTAGTAAAGCTTTGGCAATAGCAGCTGCTTATAAGCAGCAAAAGGGAAAGATAGTAATTGTGACGTCAACTCAAAATGAGGCTGAAAAACTTGCAACTGATTTAATTAGCTTAATTGGTGAGGAAGAAGTTTATCAATTTTTCGCTGATGATGTTGCAGCAGCAGAGTTTATTTTTGCATCGCAAGATAGAACAAATTCTCGTGTAGAAAGCCTTAATTTTCTTTTAGATAAAGAAAAATCAGGAATTTTAATGACAAGTATTGTTGGTATAAGGATTTTACTTCCAAGTCCCCAAAATTACCAAGCAGCTCAATTTAAATTAAAAGTTGGTGAAGAATATAATCTTGACAATATTATCAAGCAACTGTCAAATATTGGTTATCAAAAAGTAGCACAAGTTTATAATCCTGGAGAATTTAGTAAAAGAGGGGATATTTTAGATATTTATGAAATCAATCAGCCCTATCCTTATCGTCTTGAATTTTTTGGAGATGAAATAGACGGCATTCGCACTTTTGATCCTGATGATCAAAGATCCCTTAGTAATCTGGATTCTTTTATTTTGATCCCATCTGATGATATCATCCTGACAGATAGTGATTTTGATCAAGCCTGTTATAATTTAGAAAAAGCACTTATTACTGCAAATGATAGTTTACAACCTTATTTAAAAGAGGTTTTATCTGTTACGAAAGATCATTACCGTCATCAAGATGTTAGAAAGTTTTTATCCTTTTTCTATCAAAAAGAATGGACTCTTTTAAATTATCTACCTGAACAAACACCACTATTTTTTGATGATTTTCAAAGAATTATTGATCGAAATAGTCATTTTGATTTGGATATTGCTAATCTTTTGACAGAAGATTTACAAAATAGTAAAGCAGTGTCAAGTTTATCTTATTTTGCTAATAATTACAAAGATTTAAGACACTATCAACCTGCGACCTTTTTTTCTAATTTTCATAAAGGCTTAGGAAATCTTAAATTTGATTATCTCTATAACTTTACACAGTATCCAATGCAGGAATTTTTTAATCAATTTCCTTTATTAATTGATGAAATTAGACGTTATCAAAAATCTGAGATGACTGTTCTTTTACAAACAGATTCACAGCAGAGTCAAGGACGTTTACAAAAAGCTTTACAGGGATATAATTTCAATTTACCAATTAGTCAAGTTGATAATCTGTTAAAAAAGCAAGCTCAGTTAACAATTGGAAATCTTTCAACTGGTTTTTATTTTGCTGATGAAAAGCTTGTCTTAATCACTGAAAGAGAAATTTTTCATAAAAAAGTAAAGCATAAACGTCGTCGTTCATATATTAGTAATGCTGAGCGTCTTAAGGATTACAATGAATTAGAAAAGGGAGACTATGTTGTTCATAATGTGCATGGCATAGGACGTTTTTTAGGGATTGAAACGATTGAAGTGTCAGGTGTTCACCGAGATTATTTAACCATTCAATATCAAAATGCTGATCGTATTTCCATTCCTATTGAACAAATTGAACTCCTTTCAAAATATGTTGCTAGTGATGGTAAAGAGCCAAAGATCAATAAGCTTAATGATGGCCGTTTTCAAAGGATTAAACAAAAGGTATCAAAACAAGTTGAAGATATTGCTGATGATCTTTTAAAACTTTATGCTGAACGCAGTCAATTAAAAGGTTTTGCTTTTTCTCCTGATGATAAAAATCAGGAAGAATTTGATAATGATTTTGCTTATGTTGAAACTGAAGATCAATTAAGATCCATTAAAGAAGTCAAAAAGGATATGGAAAAAGACCAACCAATGGATCGTCTTCTTGTTGGTGATGTTGGTTTTGGAAAAACGGAAGTAGCGATGAGAGCTGCTTTTAAAGCAGTTAATGATGATAAACAAGTTGCTGTTTTGGTGCCAACAACAGTTCTTGCTCAACAGCACTATAATACTTTTAAGGAGCGCTTTGAAAATTTTCCTGTCAATGTTGCCATGATGAGTCGTTTTAAAACCAAGACTGAACAGTCTGAAACGTTAACTAAATTAGCTAAGGGACAGGTTGATATCATTATTGGAACACATCGTCTACTTTCTAAAGATGTTACGTTTAAAGATCTTGGTTTGCTTGTTATTGATGAAGAGCAACGATTCGGGGTTAAACACAAGGAAACATTGAAAGAATTAAAAACTAAGGTTGATGTCTTGACCTTGACAGCAACTCCTATTCCACGGACATTACATATGTCTATGCTTGGTATACGAGATTTATCAGTTATTGAAACACCTCCAAGTAATCGTTACCCTGTCCAGACTTATGTTATGGAAACAAATGCAAGTGTCATTCGTGAAGCTATTATGCGTGAAATTGATCGAGGTGGACAAATCTTTTATATTTACAACAGGGTTGACACAATTGACAAAAAAGTTGCTGAACTAAGAGAATTGATTCCAGAAGCCAACATTGGTTTTGTTCATGGAAAAATGAGCGAAATTCAACTTGAAAATACTTTACTAGACTTTATCAGTGGTGAATACGATCTCCTAGTAACTACAACAATCATTGAAACAGGTATTGATATTTCAAATGTTAATACTCTGTTTATTGAAAATGCTGATTACATGGGCTTGTCAACTTTGTATCAACTTCGGGGACGTGTTGGTCGATCAAATCGTATTGCTTATGCTTATCTTATGTATCATCCTGATAAGATTTTAACAGAAGTGTCAGAAAAACGTTTGGAAGCTATTAAAGGGTTTACAGAACTTGGTTCAGGTTTTAAAATTGCTATGAGAGATTTGTCTATTCGTGGTGCAGGAAATATTCTTGGTTCCTCTCAAAGTGGCTTCATTGATTCTGTAGGTTTTGAAATGTATTCACAGTTATTAGAAGAAGCAATTGCAGCAAAACAAGGTCAAAGAAAAACGCGTTCTAAGGGAAATGCTGAAATTAATTTACAAATTGATGCTTATTTACCAACAAATTATATTAGTGATGAGCGTCAGAAAATTGAAATTTATAAACGTATTCGAGAAATTGAAAGTAAAACAGACTATCAGGCTTTACAAGATGAACTGATTGATCGTTTTGGTGATTATCCAGATCAGGTTGCTTATCTGATAGAAATCGGTCTTTTAAAAGCTTATCTAGATGATGCCTTTGTAGAATCACTTGATCGTAAGCAAAATTCAGTAGTAGTGTGTTTTGAAAAGATTTCATTAAAATTTTATCTAACTCAGGATTATTTTGAAGCTTTGTCTAAAACTAATTTAAAAGCTCGTATTAGTGAAAATAAAGGAAAAATTGAAATTGTTTTTGATGTGCGAGCTAAAAAGGAATATGAAATTTTAGAAGAATTAATTAAATTTGGAAAAATTTTGAAGAAACTAAAAGATAAGAAAAAGTAA","5.80","-13.84","133945","MNLIDLFKQNQKIKEWTEHLSAPTRQLVMGFSSSSKALAIAAAYKQQKGKIVIVTSTQNEAEKLATDLISLIGEEEVYQFFADDVAAAEFIFASQDRTNSRVESLNFLLDKEKSGILMTSIVGIRILLPSPQNYQAAQFKLKVGEEYNLDNIIKQLSNIGYQKVAQVYNPGEFSKRGDILDIYEINQPYPYRLEFFGDEIDGIRTFDPDDQRSLSNLDSFILIPSDDIILTDSDFDQACYNLEKALITANDSLQPYLKEVLSVTKDHYRHQDVRKFLSFFYQKEWTLLNYLPEQTPLFFDDFQRIIDRNSHFDLDIANLLTEDLQNSKAVSSLSYFANNYKDLRHYQPATFFSNFHKGLGNLKFDYLYNFTQYPMQEFFNQFPLLIDEIRRYQKSEMTVLLQTDSQQSQGRLQKALQGYNFNLPISQVDNLLKKQAQLTIGNLSTGFYFADEKLVLITEREIFHKKVKHKRRRSYISNAERLKDYNELEKGDYVVHNVHGIGRFLGIETIEVSGVHRDYLTIQYQNADRISIPIEQIELLSKYVASDGKEPKINKLNDGRFQRIKQKVSKQVEDIADDLLKLYAERSQLKGFAFSPDDKNQEEFDNDFAYVETEDQLRSIKEVKKDMEKDQPMDRLLVGDVGFGKTEVAMRAAFKAVNDDKQVAVLVPTTVLAQQHYNTFKERFENFPVNVAMMSRFKTKTEQSETLTKLAKGQVDIIIGTHRLLSKDVTFKDLGLLVIDEEQRFGVKHKETLKELKTKVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPSNRYPVQTYVMETNASVIREAIMREIDRGGQIFYIYNRVDTIDKKVAELRELIPEANIGFVHGKMSEIQLENTLLDFISGEYDLLVTTTIIETGIDISNVNTLFIENADYMGLSTLYQLRGRVGRSNRIAYAYLMYHPDKILTEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNILGSSQSGFIDSVGFEMYSQLLEEAIAAKQGQRKTRSKGNAEINLQIDAYLPTNYISDERQKIEIYKRIREIESKTDYQALQDELIDRFGDYPDQVAYLIEIGLLKAYLDDAFVESLDRKQNSVVVCFEKISLKFYLTQDYFEALSKTNLKARISENKGKIEIVFDVRAKKEYEILEELIKFGKILKKLKDKKK","8719","","transcription-repair coupling factor","Cytoplasm","This sequence partly corresponds to the previously sequenced gi1661174 and gi1661175 in GenBank. Residues 636-732 are identical to residues 1-97 of gi1661174. Thiss sequence corresponds to Spy0008.Matches in gapped BLAST to transcription-repair coupling factor sequences: residues 1-1161 are 71% similar to the factor in S.pyogenes (gi15674256) and 63% similar to the factor in S.pneumoniae (gi15899955).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0008 (0.0).","

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[841-918]T$	Helicase_C
SM00490	$\"[834-918]T$	HELICc
PS51194	$\"[808-962]T$	HELICASE_CTER

InterPro
IPR003711
Domain

Transcription factor CarD
PF02559	$\"[487-584]T$	CarD_TRCF

InterPro
IPR004576
Family

Transcription-repair coupling factor
TIGR00580	$\"[156-1086]T$	mfd

InterPro
IPR005118
Domain

TRCF
PF03461	$\"[1012-1120]T$	TRCF

InterPro
IPR011545
Domain

DEAD/DEAH box helicase, N-terminal
PF00270	$\"[613-777]T$	DEAD

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[608-798]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[626-787]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[137-225]T$ $\"[634-791]T$ $\"[791-934]T$	G3DSA:3.40.50.300
SSF52540	$\"[4-318]T$	SSF52540

","BeTs to 10 clades of COG1197COG name: Transcription-repair coupling factor - helicase of superfamily IIFunctional Class: L,KThe phylogenetic pattern of COG1197 is ------vcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 347-493 are 48% similar to a (TRANSCRIPTION-REPAIR COUPLING FACTOR) protein domain (PD407719) which is seen in Q9CJI0_LACLA.Residues 1-81 are 34% similar to a (PROTEOME FACTOR COMPLETE COUPLING) protein domain (PD390980) which is seen in Q9CJI0_LACLA.Residues 348-492 are 34% similar to a (COUPLING ATP-BINDING FACTOR) protein domain (PD359059) which is seen in Q9KGJ2_BACHD.Residues 839-881 are 72% similar to a (HELICASE DNA ATP-BINDING COUPLING) protein domain (PD254019) which is seen in Q9CJI0_LACLA.Residues 882-989 are 87% similar to a (HELICASE DNA ATP-BINDING PROTEOME) protein domain (PD008437) which is seen in Q9CJI0_LACLA.Residues 771-834 are 81% similar to a (HELICASE DNA ATP-BINDING ATP-DEPENDENT) protein domain (PD035483) which is seen in Q9CJI0_LACLA.Residues 634-927 are 23% similar to a (PROTEOME COMPETENCE COMPLETE ATP-BINDING) protein domain (PD132737) which is seen in CMF1_BACSU.Residues 642-740 are 76% similar to a (HELICASE DNA ATP-BINDING COMPLETE PROTEOME DNA-BINDING) protein domain (PD003500) which is seen in Q9CJI0_LACLA.Residues 229-346 are 31% similar to a (PROTEOME FACTOR COMPLETE COUPLING) protein domain (PD396160) which is seen in Q9CJI0_LACLA.Residues 1013-1086 are 44% similar to a (COUPLING TRANSCRIPTION-REPAIR FACTOR) protein domain (PD105103) which is seen in Q9CJI0_LACLA.Residues 82-227 are 47% similar to a (ATP-BINDING REPAIR DNA SUBUNIT) protein domain (PD002798) which is seen in Q9CJI0_LACLA.Residues 494-641 are 69% similar to a (COUPLING TRANSCRIPTION-REPAIR HELICASE) protein domain (PD339344) which is seen in Q9CJI0_LACLA.Residues 771-835 are 56% similar to a (COUPLING TRANSCRIPTION-REPAIR FACTOR) protein domain (PD190278) which is seen in Q9KQW2_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 12:27:34 2002","Fri Nov 30 13:51:03 2001","Fri Feb 3 08:30:04 2006","Thu Apr 4 15:19:16 2002","","Wed Jan 9 12:24:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0006 is paralogously related (blast p-value < 1e-3) to SMu1669, SMu0734, SMu0434, SMu0451, and SMu0557, predicted helicases and replication factors.","Wed Jan 9 12:27:34 2002","Fri Feb 3 08:30:04 2006","pdb1C4OA Chain A, Crystal Structure Of The Dna Nucleotide Exc... 67 1e-011pdb1D2MA Chain A, Uvrb Protein Of Thermus Thermophilus Hb8; A... 67 1e-011","SMU.08","Fri Nov 30 13:51:03 2001","Residues 487 to 584 (E-value = 3.1e-51) place SMu0006 in the CarD_TRCF family which is described as CarD-like/TRCF domain (PF02559)Residues 602 to 798 (E-value = 1.8e-36) place SMu0006 in the DEAD family which is described as DEAD/DEAH box helicase (PF00270)Residues 841 to 918 (E-value = 1.5e-17) place SMu0006 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)Residues 1012 to 1120 (E-value = 1.9e-41) place SMu0006 in the TRCF family which is described as TRCF domain (PF03461)","Fri Feb 3 08:30:04 2006","24378538","","","Selby,C.P. and Sancar,A.Molecular mechanism of transcription-repair couplingScience 260 (5104), 53-58 (1993)PubMed: 8465200Zeng X, Galinier A, Saxild HH.Catabolite repression of dra-nupC-pdp operon expression in Bacillus subtilis.Microbiology. 2000 Nov;146 ( Pt 11):2901-8.PMID: 11065368Zalieckas JM, Wray LV Jr, Ferson AE, Fisher SH.Transcription-repair coupling factor is involved in carbon catabolite repression of the Bacillus subtilis hut and gnt operons.Mol Microbiol. 1998 Mar;27(5):1031-8.PMID: 9535092 ","Fri Feb 3 08:30:04 2006","Thu Apr 4 15:19:16 2002","1","","1","SMU.08","3" "SMu0007","8852","9124","273","ATGAGATTAGATAAATATTTAAAGGTATCACGTATTATTAAACGTCGGTCTGTGGCTAAGGAAGTTTCTGATAAAGGACGAATTAAAGTAAATGGCATTCTGGCTAAAAGTTCAACAGACTTAAAAATAAATGACACCATTGAAATACGTTTTGGTAATAAATTATTGACTGTTCGTGTTTTAGAAATGAAAGATAGCACCAAAAAAGAAGATGCTGTAAAAATGTATGAAATAATAAGTGAGACGAGGATTGACTTAAATGGAGAAACCTAA","10.60","6.99","10338","MRLDKYLKVSRIIKRRSVAKEVSDKGRIKVNGILAKSSTDLKINDTIEIRFGNKLLTVRVLEMKDSTKKEDAVKMYEIISETRIDLNGET","9121","","small RNA binding protein","Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0010 (2e-38).This sequence corresponds to Spy0009.","

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[1-47]T$	S4
SM00363	$\"[1-62]T$	S4
PS50889	$\"[1-62]T$	S4

noIPR
unintegrated

unintegrated
G3DSA:3.10.290.10	$\"[1-83]T$	G3DSA:3.10.290.10
SSF55174	$\"[1-84]T$	SSF55174

","BeTs to 4 clades of COG1188COG name: Predicted small RNA-binding protein (S4 paralog)Functional Class: JThe phylogenetic pattern of COG1188 is ------v-eb-huj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-60 are 63% similar to a (SHOCK RNA-BINDING HEAT COMPLETE) protein domain (PD021159) which is seen in YO4L_LISMO.Residues 1-60 are 80% similar to a (PROTEOME COMPLETE BH0073 RNA-BINDING) protein domain (PD348801) which is seen in Q9CJH8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 11:12:07 2002","Thu Oct 17 11:12:07 2002","Tue Sep 5 09:09:08 2006","Thu Apr 7 19:38:32 2005","","Mon Oct 7 13:48:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0007 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 11:12:07 2002","Thu Apr 7 19:38:32 2005","pdb1DM9B Chain B, Heat Shock Protein 15 Kd >gi7245731pdb1D... 131 2e-032","SMU.09","Fri Nov 30 14:22:24 2001","Residues 1 to 47 (E-value = 6.9e-08) place SMu0007 in the S4 family which is described as S4 domain (PF01479)","Mon Oct 7 13:48:30 2002","24378539","","","","","","1","","1","SMU.09","871" "SMu0008","9111","9482","372","ATGGAGAAACCTAACATTGTTCAGCTTAATAACAAATACATTAATGATGAAAAAACTAAAAAACGTTATGAAGAAGAAGAAACCAAACGTCGCCATCGTTTTATTGGGTGGATTTTGATTTTTATTATTTTATTATTTATTTTACCGGCCTATAACCTTGTAGCTAGTTATATGAATTTGCAAAGTAAAAAAGAACAAATTGTAAAACTACAAAATCAACAGAAAAGATTAGATGCTAAAACAGATGCTGAGAAAAAATTTGCTGATCGTTTAAAAGATGATAATTATGTTGAGAAGTATGCACGTGCTAAATATTATTATTCAATAGATGGTGAAAATATTTACCCTGCTCCAAATTTATTACCTAAATAA","10.30","7.23","14819","MEKPNIVQLNNKYINDEKTKKRYEEEETKRRHRFIGWILIFIILLFILPAYNLVASYMNLQSKKEQIVKLQNQQKRLDAKTDAEKKFADRLKDDNYVEKYARAKYYYSIDGENIYPAPNLLPK","9479","","cell-division protein DivIC","Periplasm, Membrane, Extracellular","Matches in gapped BLAST to hypothetical proteins and DivIC homologs: residues 1-123 are 57% similar to a possible DivIC protein in S.pyogenes (gi15674258). Residues 5-123 are 47% similar to a hypothetical from S.pneumoniae (gi15899957).See Spy0010.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0011 (1e-26).","

InterPro
IPR007060
Family

Septum formation initiator
PF04977	$\"[42-120]T$	DivIC

InterPro
IPR000215
Family

Proteinase inhibitor I4, serpin
PS00284	$\"[372-382]?$	SERPIN

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[166-403]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[163-375]T$	G3DSA:3.40.710.10
SSF82057	$\"[92-162]T$	SSF82057

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 13-404 are 33% similar to a (PROTEOME COMPLETE YACG) protein domain (PD402010) which is seen in Q9CJH5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 3 09:23:29 2006","Fri Nov 30 14:07:30 2001","Fri Feb 3 09:23:29 2006","Mon Oct 7 13:50:16 2002","","Mon Oct 7 13:50:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0010 is paralogously related (blast p-value < 1e-3) to SMu0572.","Fri Feb 3 09:23:29 2006","Fri Feb 3 09:25:55 2006","","SMU.12","Fri Nov 30 14:07:30 2001","No significant hits to the Pfam 11.0 database","Mon Oct 7 13:50:16 2002","24378542","","","","","","1","","1","SMU.12","213" "SMu0011","10843","12114","1272","ATGACTTATGAAAAAGTGTTAAAGTATGTTCAAGAGAAAAAATTTTTTGAGACGCATTATAACATTCTAATAGCTGTATCAGGTGGGGTAGATTCGATGAATTTGCTGCACTTTTTGCATATTTACCAGAAAAAACTGCAAATTAGAATAGCTGTAGCTCATGTGAATCACAAACAGAGACCACAAGCTGATGAAGAAGAAATTTATCTTAAAAATTGGGCACGAGACAATCATATTCCTTTTTATACTGCTGTTTTTAAGGGAATTTTTTCAGAAAAAAAGGCGCGTGATTTTCGTTATACTTTTTTCAAAAATATAATGAAAGAGCATGGATATACAGCTCTTGTTACGGCTCATCATGCTAATGATCAGGCTGAGACAGTCTTTTTACGTTTACTCAGAGGATCACGCTTACGATATTTGACTGGTATTAAAGAAATTCAGGAGTTTGGCAATGGCCAACTGATTCGTCCTTTTTTAAAATTTCACAAGAAGGAACTACCAAATATTTTCCATTTTGATGATGATTCAAATCAAGGAGATTCTTATCTTAGAAATAGAATCAGAAATCATTACTTGCCTATTTTGACACAGGAAAATCCTAAATTAAGTCAGCATTTAATCCAAATGAGTGAAGAAACAAATCTCCTTTTCAAGGCTTTTTCAGATTTAACCTCGCAATTAGATATTCAAGATTGTCAAATTTTTAGAAGTCAAAGTGAGGCAATACAGTACTTTTTATTGCAGAACTATCTAAGAAAATTTCCAAATTTAGAAGTCAGCAAAGCTCAATTTGATAATTTGCTTCATATTCTGAGAACAAAAGATTATTACTATGATTATTTAAAAAATAATTACTATTTGAAAAAAGACAAAAAAAGGTTCAAAATTTGTAAAATAGGTCCTGAGACGGATAGATTTGAAGGCGAAAAAGTATTAGAATATGGCAGTATGGTCAAATATGGTCAGTACATTTTCTCTTTTCAAGAGGGTTCAGATTCAAAAAAAGGAATCCCTGTAAAAAATGATTTTCCTATTATTATAAGACGTCGTAAGCCTGGGGACAAAATCAAATTAGGAAGTCATTCTAAAAAATTGCGACGTTTATTTATAGATGAAAAAATTCCTATTTTTAAACGTTCAAATGCTATTATTGTTGAACAAGATAGCGATATTATATTAATTCTTTTAGATGGAGTTACTTATTTGAGAAAAGGTTTTAAAGATGATATAATGAAAGGCAGACTGTATATTCAAAATAGAAATTGGTGA","10.40","24.54","50402","MTYEKVLKYVQEKKFFETHYNILIAVSGGVDSMNLLHFLHIYQKKLQIRIAVAHVNHKQRPQADEEEIYLKNWARDNHIPFYTAVFKGIFSEKKARDFRYTFFKNIMKEHGYTALVTAHHANDQAETVFLRLLRGSRLRYLTGIKEIQEFGNGQLIRPFLKFHKKELPNIFHFDDDSNQGDSYLRNRIRNHYLPILTQENPKLSQHLIQMSEETNLLFKAFSDLTSQLDIQDCQIFRSQSEAIQYFLLQNYLRKFPNLEVSKAQFDNLLHILRTKDYYYDYLKNNYYLKKDKKRFKICKIGPETDRFEGEKVLEYGSMVKYGQYIFSFQEGSDSKKGIPVKNDFPIIIRRRKPGDKIKLGSHSKKLRRLFIDEKIPIFKRSNAIIVEQDSDIILILLDGVTYLRKGFKDDIMKGRLYIQNRNW","12111","","cell-cycle protein, PP-loop superfamily","Cytoplasm","Matches in gapped BLAST to probable cell cycle proteins: residues 1-418 are 55% similar to gi15674260 of S.pyogenes. Residues 7-419 are 47% similar to a predicted MesJ/Ycf62 family protein from S.pneumoniae (gi15899960).See Spy00113.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0014 (1e-113).","

InterPro
IPR011063
Domain

PP-loop
PF01171	$\"[21-191]T$	ATP_bind_3

InterPro
IPR012094
Family

Cell cycle control PP-loop ATPase MesJ/YaeO
PIRSF006290	$\"[3-421]T$	MesJ_YaeO
PTHR11807:SF2	$\"[29-406]T$	ATPase_MesJ_YaeO

InterPro
IPR012795
Domain

tRNA(Ile)-lysidine synthetase, N-terminal
TIGR02432	$\"[21-194]T$	lysidine_TilS_N

InterPro
IPR012796
Domain

tRNA(Ile)-lysidine synthetase, C-terminal
TIGR02433	$\"[346-390]T$	lysidine_TilS_C

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[7-175]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
PTHR11807	$\"[29-406]T$	PTHR11807
SSF52402	$\"[7-224]T$	SSF52402
SSF82829	$\"[217-421]T$	SSF82829

","BeTs to 14 clades of COG0037COG name: Predicted ATPases of the PP-loop superamilyFunctional Class: RThe phylogenetic pattern of COG0037 is AMTKyQVcEbrHUJgpolINxNumber of proteins in this genome belonging to this COG is 1","***** IPB000541 (Uncharacterized protein family UPF0021) with a combined E-value of 7.4e-10. IPB000541B 20-38 IPB000541D 99-137","Residues 329-419 are 34% similar to a (PROTEOME COMPLETE MESJ CELL) protein domain (PD396046) which is seen in Q9CJH4_LACLA.Residues 23-102 are 34% similar to a (PROTEOME MG084 UU077 COMPLETE) protein domain (PD404530) which is seen in Y579_THEMA.Residues 22-84 are 44% similar to a (PROTEOME COMPLETE MESJ CELL) protein domain (PD103750) which is seen in Q9KGH8_BACHD.Residues 22-106 are 44% similar to a (PROTEOME COMPLETE CYCLE MESJ) protein domain (PD190304) which is seen in Q9CJH4_LACLA.Residues 43-167 are 31% similar to a (PROTEOME COMPLETE PP-LOOP ATPASE) protein domain (PD096379) which is seen in MESJ_BUCAI.Residues 115-272 are 41% similar to a (PROTEOME COMPLETE CELL CYCLE CHLOROPLAST HOMOLOG) protein domain (PD003493) which is seen in Q9CJH4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 11:33:36 2002","Fri Sep 1 16:09:55 2006","Fri Feb 3 09:27:33 2006","Tue Oct 29 07:52:18 2002","Mon Oct 7 13:51:36 2002","Mon Oct 7 13:51:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0011 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 11:33:36 2002","","No significant hits to the NCBI PDB database.","SMU.13","Fri Nov 30 14:50:26 2001","Residues 21 to 213 (E-value = 7.9e-87) place SMu0011 in the ATP_bind_3 family which is described as PP-loop family (PF01171)","Mon Oct 7 13:51:36 2002","24378543","","","","","","1","","1","SMU.13","214" "SMu0012","12118","12660","543","ATGCTTGAACAGAATATTAAGAAAGTTCTCTATTCTGAAGAGGAAATCATTGTTAAAACAAAAGAATTAGGTGCTCAGTTAACCAAAGATTATGCTGGTAAAAATCCACTTTTAGTGGGTGTTTTAAAAGGTTCTGTCCCTTTTATGGCTGAGTTAATGAAACATATTGATACTCATATTGAGATTGATTTCATGGTCGTATCAAGTTACCATGGCGGAACCACGAGTAGTGGTGAAGTGAAGATTTTAAAAGATGTTGATACTAACATTGAAAATCGCGATGTTATCTTTATTGAAGACATTATTGATACAGGCCGAACCTTGAAATATCTACGTGATATGTTCAAGTATCGTCAAGCAAATTCTGTGAGGATTGCCACACTATTTGACAAACCAGAAGGTCGTGTTGTTGATATTGACGCGGATTATGTTTGTTATAAAGTGCCTAATGAATTTATTGTTGGTTTTGGATTAGATTATGCTGAAAACTATCGTAATCTTCCTTATGTAGGAGTCTTGAAAGAAGACGTTTATTCAAAATAA","5.00","-5.32","20526","MLEQNIKKVLYSEEEIIVKTKELGAQLTKDYAGKNPLLVGVLKGSVPFMAELMKHIDTHIEIDFMVVSSYHGGTTSSGEVKILKDVDTNIENRDVIFIEDIIDTGRTLKYLRDMFKYRQANSVRIATLFDKPEGRVVDIDADYVCYKVPNEFIVGFGLDYAENYRNLPYVGVLKEDVYSK","12657","","hypoxanthine-guanine phosphoribosyltransferase","Cytoplasm","Matches in gapped BLAST to HprT proteins, e.g. residues 1-179 are 73% similar to the enzyme in S.pneumoniae (gi15899961). Residues 1-180 are 67% similar to gi15672002 of L.lactis subsp. lactis.This sequence is similar to Spy0014.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0015 (5e-95).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[5-149]T$	Pribosyltran

InterPro
IPR005904
Family

Hypoxanthine phosphoribosyl transferase
TIGR01203	$\"[9-174]T$	HGPRTase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2020	$\"[4-180]T$	G3DSA:3.40.50.2020
PTHR22573	$\"[1-180]T$	PTHR22573
PTHR22573:SF9	$\"[1-180]T$	PTHR22573:SF9
SSF53271	$\"[3-176]T$	SSF53271

","BeTs to 6 clades of COG0634COG name: Hypoxanthine-guanine phosphoribosyltransferaseFunctional Class: FThe phylogenetic pattern of COG0634 is -----qv-ebrh--gp-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 9-82 are 41% similar to a (PHOSPHORIBOSYLTRANSFERASE HYPOXANTHINE-GUANINE HGPRTASE) protein domain (PD003271) which is seen in Q9ZNK6_CLOHI.Residues 9-154 are 65% similar to a (TRANSFERASE PHOSPHORIBOSYLTRANSFERASE) protein domain (PD000249) which is seen in HPRT_LACLA.Residues 135-171 are 54% similar to a (HYPOXANTHINE TRANSFERASE) protein domain (PD234806) which is seen in HPRT_SALTY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 13:54:39 2002","Fri Nov 30 15:03:15 2001","Tue Mar 6 12:44:03 2007","Fri Feb 3 09:35:22 2006","","Wed Jan 9 12:31:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0012 is paralogously related (blast p-value < 1e-3) to SMu0780, a predicted pyrimidine regulatory protein.","Mon Oct 7 13:54:39 2002","Fri Feb 3 09:35:22 2006","pdb1HGXA Chain A, Hypoxanthine-Guanine-Xanthine Phosphoribosy... 157 7e-040pdb1TC2B Chain B, Ternary Substrate Complex Of The Hypoxanthi... 145 3e-036pdb1TC1B Chain B, A 1.4 Angstrom Crystal Structure For The Hy... 145 3e-036","SMU.14","Fri Nov 30 15:03:15 2001","Residues 5 to 149 (E-value = 2.7e-33) place SMu0012 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Wed Jan 9 12:31:21 2002","24378544","","","","","","1","","1","SMU.14","506" "SMu0013","12682","14652","1971","ATGAAAAATAATCGAAATAATGGATTTGTTAGAAATTCTCTTGTTTATATCATATTGATTTTAGCTATTGTGACAGGTTTTCAATATTTTTTTAGAGGAACAGGTTCACAAAGTGAAAAAATTAGTTATACAACTCTCGTTAAACGCGTCAAATCGGGTGATATAAAATCAATTACTTACCAACCAAGTGGTAGTATCGTCCAAGTAACAGGTGATTACACAAAGTCTCGGGAAATTAAAACTAACAGTGACTTAGCTTTTTTCAACGGGACAACAACAAAAGTTAAAAAGTTTACCTCAATTGTCCTTCCTAATAGTACTTCTATTGAAAAAATTGAAAAATTAGCAGAAGATAAAGGAACTAAAATTTCTGTTAAACAAGAGAGTTCAAGCGGAGCTTGGATCTCCTTCTTAATGAGTTTCTTGCCAATTTTCATAATGATCTTCTTCTTCACTATGATGTTAAATCAAAGTGGCGGCGGTGCCCGTGGTGCCATGAGTTTTGGTAAAAATAAAGCTCGTTCTTCTTCTAAAAGTGATGTTAAGGTTCGATTCTCAGATGTTGCTGGTGCAGAAGAAGAAAAACAAGAACTTATTGAAGTTGTTGATTTTCTAAAAGATCCTAAACGTTATAATGCTTTAGGTGCTCGTATTCCAGCCGGTGTTCTGCTTGAAGGCCCTCCAGGAACAGGAAAAACACTTCTTGCTAAAGCAGTAGCCGGTGAAGCTGGTGTTCCGTTCTTCTCTATTTCTGGTTCTGACTTTGTTGAAATGTTTGTTGGGGTTGGTGCTAGCCGCGTTCGTTCATTATTTGAAGATGCTAAGAAAGCAGAGCGTGCCATTATCTTTATTGATGAAATTGATGCGGTCGGTCGTCGCCGTGGCGCTGGTATGGGCGGCGGAAATGATGAACGCGAACAAACACTTAACCAACTGTTGATTGAAATGGATGGTTTTGAAGGTAATGAAAATATTATTGTTATTGCAGCAACCAACCGTAGTGATGTCTTGGATCCAGCCCTTCTTCGTCCAGGTCGTTTTGACCGTAAAGTTCTTGTTGGTCAACCAGATGTTAAAGGTCGTGAAGCGATTTTACGTGTTCATGCTAAAAACAAACCTCTAGCTAGTGATGTTAATCTAAAAGTTGTTGCGCAACAAACACCAGGTTTTGTAGGTGCTGATTTAGAAAATGTTCTGAATGAAGCTGCTCTTGTTGCTGCCCGTCGCAGTAAAAAAATTATTGATGCCAGTGATATTGATGAAGCAGAAGATCGCGTTATTGCAGGCCCGTCTAAGAAAGATAAGACTGTTTCTGAACATGAACGTCAGATGATTGCCTACCACGAAGCTGGACATACCATTGTAGGACTTGTTTTATCGAATGCACGAGTTGTTCATAAAGTTACTATTGTTCCTCGTGGTCGAGCTGGCGGTTACATGATTGCTCTTCCAAAAGAAGATCAAAATCTCTTATCAAAAAGTGATTTGAAGGAACAGTTAGCTGGACTGATGGGAGGACGTGTCGCAGAAGAAATTATCTTCAATGCTCAAACAACAGGTGCTTCAAATGACTTTGAACAAGCCACTCAATTGGCACGATCAATGGTAACAGAATATGGTATGAGTGAAAAGCTCGGTCCAGTTCAATATGAAGGTAATCATTCAATGATGCCAGGACAATTTGCATCAGAAAAGACTTATTCAGCACAAACAGCCCTTCTTATTGATGAAGAAGTTCGTGAACTTCTTAATGAAGCTCGCAATAAGGCAGCTGGAATTATCAATGATAATCGTGAAACGCATAAATTAATTGCAGAAGCGCTTCTTAAATATGAAACTTTGGATGCAGCGCAAATTAAATCTATTTATGAGACTGGTAAGATGCCTGAAAAATCAGAGGATTCAAAGGATGCACATGCGCTTTCTTATGATGAAATAAAAGAAAAAATGTCTGAAGATAATACTGATTAA","7.00","0.00","71711","MKNNRNNGFVRNSLVYIILILAIVTGFQYFFRGTGSQSEKISYTTLVKRVKSGDIKSITYQPSGSIVQVTGDYTKSREIKTNSDLAFFNGTTTKVKKFTSIVLPNSTSIEKIEKLAEDKGTKISVKQESSSGAWISFLMSFLPIFIMIFFFTMMLNQSGGGARGAMSFGKNKARSSSKSDVKVRFSDVAGAEEEKQELIEVVDFLKDPKRYNALGARIPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAKKAERAIIFIDEIDAVGRRRGAGMGGGNDEREQTLNQLLIEMDGFEGNENIIVIAATNRSDVLDPALLRPGRFDRKVLVGQPDVKGREAILRVHAKNKPLASDVNLKVVAQQTPGFVGADLENVLNEAALVAARRSKKIIDASDIDEAEDRVIAGPSKKDKTVSEHERQMIAYHEAGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQNLLSKSDLKEQLAGLMGGRVAEEIIFNAQTTGASNDFEQATQLARSMVTEYGMSEKLGPVQYEGNHSMMPGQFASEKTYSAQTALLIDEEVRELLNEARNKAAGIINDNRETHKLIAEALLKYETLDAAQIKSIYETGKMPEKSEDSKDAHALSYDEIKEKMSEDNTD","14649","For other 'fts' genes, see SMu0501 (ftsA); SMu0500 (ftsQ); SMu0502 (ftsZ);SMu0650 (ftsW); SMu0676 (ftsY); SMu0411 (ftsL); SMu1209 (ftsX); SMu1210 (ftsE) and SMu1483 (ftsK). ","cell division protein FtsH","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to ftsH proteins: residues 1-655 are 80% similar to the protein in S.pyogenes (gi15674261). Residues 5-653 are 74% similar to the ftsH from S.pneumoniae (gi15899962).See Spy0015.This sequence is very weakly related to the previously sequenced AAD00283 in GenBANK.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0016 (0.0).","

InterPro
IPR000642
Domain

Peptidase M41
PF01434	$\"[415-622]T$	Peptidase_M41

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[218-357]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[221-408]T$	AAA

InterPro
IPR003960
Domain

AAA ATPase, subdomain
PS00674	$\"[325-343]T$	AAA

InterPro
IPR005936
Domain

Peptidase M41, FtsH
TIGR01241	$\"[133-624]T$	FtsH_fam

InterPro
IPR011546
Domain

Peptidase M41, FtsH extracellular
PF06480	$\"[39-195]T$	FtsH_ext

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.60	$\"[356-424]T$	G3DSA:1.10.8.60
G3DSA:3.40.50.300	$\"[171-353]T$	G3DSA:3.40.50.300
PTHR23076	$\"[15-613]T$	PTHR23076
PTHR23076:SF10	$\"[15-613]T$	PTHR23076:SF10
SSF52540	$\"[165-555]T$	SSF52540

","BeTs to 13 clades of COG0465COG name: ATP-dependent Zn proteasesFunctional Class: OThe phylogenetic pattern of COG0465 is ----YqvCeBrHUJgpoLinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000642 (Peptidase family M41) with a combined E-value of 1.5e-169. IPB000642A 185-233 IPB000642B 251-295 IPB000642C 324-368 IPB000642D 383-408 IPB000642E 440-476 IPB000642F 504-515 IPB000642G 517-542***** IPB003338 (Amino-terminal subdomain, VAT-Nn) with a combined E-value of 1.6e-57. IPB003338H 173-212 IPB003338I 226-270 IPB003338J 271-295 IPB003338K 313-366***** IPB003960 (AAA-protein subfamily) with a combined E-value of 8.6e-48. IPB003960A 261-294 IPB003960B 311-357","Residues 222-367 are 25% similar to a (ATP-BINDING PACHYTENE CHECKPOINT) protein domain (PD094493) which is seen in PCH2_YEAST.Residues 188-289 are 32% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD014521) which is seen in Q9HPV0_HALN1.Residues 159-365 are 26% similar to a (PROTEOME COMPLETE) protein domain (PD137110) which is seen in P96281_MYCTU.Residues 11-171 are 23% similar to a (DIVISION CELL FTSH PROTEOME) protein domain (PD108785) which is seen in FTSH_BACSU.Residues 2-169 are 29% similar to a (DIVISION CELL FTSH METALLOPROTEASE) protein domain (PD105897) which is seen in FTSH_LACLA.Residues 427-622 are 59% similar to a (DIVISION CELL ZINC METALLOPROTEASE HYDROLASE HOMOLOG) protein domain (PD002293) which is seen in FTSH_LACLA.Residues 302-332 are 87% similar to a (DIVISION CELL ZINC METALLOPROTEASE HYDROLASE ATP-BINDING) protein domain (PD359519) which is seen in Q9KU86_VIBCH.Residues 223-384 are 48% similar to a (REPLICATION ATP-BINDING DNA-BINDING INITIATOR) protein domain (PD002717) which is seen in YB56_METJA.Residues 170-218 are 65% similar to a (PROTEASOME SUBUNIT ATP-BINDING 26S CELL DIVISION) protein domain (PD337570) which is seen in FTSH_LACLA.Residues 377-408 are 81% similar to a (CELL DIVISION ATP-BINDING ATPASE) protein domain (PD000272) which is seen in Q9KGH6_BACHD.Residues 335-369 are 91% similar to a (CELL ATP-BINDING DIVISION SUBUNIT) protein domain (PD186075) which is seen in FTSH_LACLA.Residues 172-288 are 75% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in FTSH_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 13:56:09 2006","Fri Nov 30 15:17:02 2001","Fri Feb 3 09:40:22 2006","Wed Apr 3 08:29:02 2002","Wed Jan 9 12:33:03 2002","Wed Jan 9 12:33:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0013 is paralogously related (blast p-value < 1e-3) to SMu0861 and SMu0868, both predicted ATP-dependent Clp proteases, and to SMu1866, a predicted helicase.","Wed Jan 9 12:34:43 2002","","No significant hits to the NCBI PDB database.","SMU.15","Fri Nov 30 15:17:02 2001","Residues 39 to 195 (E-value = 5.2e-35) place SMu0013 in the FtsH_ext family which is described as FtsH Extracellular (PF06480)Residues 221 to 408 (E-value = 2.4e-92) place SMu0013 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)Residues 414 to 622 (E-value = 1.7e-106) place SMu0013 in the Peptidase_M41 family which is described as Peptidase family M41 (PF01434)","Fri Feb 3 09:40:22 2006","24378545","","","Tomoyasu,T., Yuki,T., Morimura,S., Mori,H., Yamanaka,K., Niki,H.,Hiraga,S. and Ogura,T.The Escherichia coli FtsH protein is a prokaryotic member of aprotein family of putative ATPases involved in membrane functions,cell cycle control, and gene expressionJ. Bacteriol. 175 (5), 1344-1351 (1993)PubMed: 8444796Chiba S, Akiyama Y, Mori H, Matsuo E, Ito K.Length recognition at the N-terminal tail for the initiation of FtsH-mediated proteolysis.EMBO Rep. 2000 Jul;1(1):47-52.PMID: 11256624Karata K, Verma CS, Wilkinson AJ, Ogura T.Probing the mechanism of ATP hydrolysis and substrate translocation in the AAA protease FtsH by modelling and mutagenesis.Mol Microbiol. 2001 Feb;39(4):890-903.PMID: 11251810","","Wed Apr 3 08:29:02 2002","1","","1","SMU.15","4" "SMu0014","15140","16555","1416","ATGATGACTATTTTCAGAAAGAAGAATACTAATTTAGATAAAACAGAAATGAAACGTCACTTTAAAGTAATTGATCTAATTTTTCTTGGATTAGGATCAATGGTTGGAACAGGAATTTTTACAATTACTGGTATTGGTGCAGCTAAGTATGCGGGTCCTGCTTTGATTATTTCAATTATTGTTTCGGCAATTGCCGTTGGAATTTCTGCACTTTTCTATGCTGAATTTACTTCTCGAATACCTGCAAATGGTGGAGCTTACAGCTACTTATATGCTACTTTGGGAGAATTTCCCGCTTGGTTAGCTGGTTGGTACATTATTATGGAATTTCTTACTGCAATTTCAAGTGTAGCATCTGGTTGGGGAAGTTATTTCAAGGGATTGTTATCAAGCTATGGTATTGAATTACCATCTTTGCTTAATGGTACTTTTAATCCAGCTAAAAATAATTACATTGACTTGCTTCCTGCCTTAGTCATTTTTTTAGTCACAGGAATCGTGTTATTAAATTCTAAAATTGCCTTACGCTTTAATAGTAGTTTAGTTGTAATGAAATTTTCTGCCTTAGCCCTTTTTATAATTATTGGATTGTTTTATATAAAACCTGAAAATTGGTCTAATTTTGCACCTTTTGGTTTTGGAAAAATTTATGGTGGACAAACTGGAATAATGGCTGGCGCTTCTTTGATGTTTTTTGCATTTTTGGGATTTGAATCTATTTCAATGGCAGTGGATGAAGTTCAAAAACCACAAAAAAATATTCCCAAAGGTATTATTGCTTCTTTAACGATTGTTACCATTCTTTATGTTAGTGTTACTCTTGTATTAACTGGTATTGTTCATTATTCTAAATTAAATGTTGCCGATGCAGTTGCCTTTGCACTTCGTCAAGCGGGTTTGGTATGGGCAGCAAACTATATTTCAGTTGTTGCGATTCTGACTCTTATAACAGTTTGCATTTCTATGACTTTTGCTTTAGCTAGAACCGTTTATAGTATTAGTCGTGATGGATTATTGCCAAAACAACTCGGCATTGTTACCAAACATAGCAAGGTTCCGAAAAATGCTACTCTTCTTGTTGGTTTTGCTTCTATGATTTGTGCTGGAGTTTTTCCGCTTTCTAGCATTGCAGAATTTTTAAATATTTGTACCCTAGCTTATCTTATTATGTTGGCCATTGCTATTATCAAGCTCAGAAAAGATCAGGGACAACCTAAAATTGGAGAATTCAAAACACCATTTATCCCATTTTTACCTATTGTTTCTATAGTTATATGCTTATCTCTTATGAGTCAATATAAGTCTGTCACTTGGATTGCATTTGGAATCAGTACATCTATAGGTTTCTTAATTTACTTTGCATATGGCTATAGACATTCAACTATTTTCATAAAAAATAATCCAAAAATTAGATAG","10.50","20.76","51244","MMTIFRKKNTNLDKTEMKRHFKVIDLIFLGLGSMVGTGIFTITGIGAAKYAGPALIISIIVSAIAVGISALFYAEFTSRIPANGGAYSYLYATLGEFPAWLAGWYIIMEFLTAISSVASGWGSYFKGLLSSYGIELPSLLNGTFNPAKNNYIDLLPALVIFLVTGIVLLNSKIALRFNSSLVVMKFSALALFIIIGLFYIKPENWSNFAPFGFGKIYGGQTGIMAGASLMFFAFLGFESISMAVDEVQKPQKNIPKGIIASLTIVTILYVSVTLVLTGIVHYSKLNVADAVAFALRQAGLVWAANYISVVAILTLITVCISMTFALARTVYSISRDGLLPKQLGIVTKHSKVPKNATLLVGFASMICAGVFPLSSIAEFLNICTLAYLIMLAIAIIKLRKDQGQPKIGEFKTPFIPFLPIVSIVICLSLMSQYKSVTWIAFGISTSIGFLIYFAYGYRHSTIFIKNNPKIR","16552","","amino acid permease","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to amino acid transporters/permeases: residues 2-460 are 75% similar to gi15674262 of S.pyogenes and 70% similar to gi15902949 of S.pneumoniae.This sequence is similar to Spy0016.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1306 (2e-14).","

InterPro
IPR002293
Family

Amino acid/polyamine transporter I
PTHR11785	$\"[15-461]T$	AA/rel_permease1

InterPro
IPR004841
Domain

Amino acid permease-associated region
PF00324	$\"[25-429]T$	AA_permease

noIPR
unintegrated

unintegrated
PIRSF006060	$\"[15-471]T$	AA_transporter
PTHR11785:SF53	$\"[15-461]T$	Cat-AATrans

","BeTs to 11 clades of COG0531COG name: Amino acid transportersFunctional Class: EThe phylogenetic pattern of COG0531 is AMt-Y--cEBRh--GP--INXNumber of proteins in this genome belonging to this COG is 3","***** IPB002027 (Amino acid permease) with a combined E-value of 3.1e-33. IPB002027A 24-52 IPB002027C 232-270 IPB002027D 313-352","Residues 291-372 are 34% similar to a (AMINO ACID TRANSPORT TRANSPORTER PROTEOME COMPLETE) protein domain (PD004899) which is seen in O07576_BACSU.Residues 399-460 are 53% similar to a (AMINO ACID TRANSPORTER CATIONIC) protein domain (PD034712) which is seen in CTR2_MOUSE.Residues 126-210 are 28% similar to a (AMINO ACID CATIONIC TRANSPORTER) protein domain (PD031637) which is seen in O69844_STRCO.Residues 84-197 are 41% similar to a (ACID AMINO PROTEOME COMPLETE) protein domain (PD000214) which is seen in O06479_BACSU.Residues 51-213 are 21% similar to a (Y53F4B.12) protein domain (PD400579) which is seen in Q9NAB9_CAEEL.Residues 294-372 are 37% similar to a (TRANSPORT PERMEASE AMINO-ACID TRANSMEMBRANE COMPLETE) protein domain (PD000262) which is seen in Q9RCX2_STRCO.Residues 219-280 are 48% similar to a (TRANSPORT AMINO ACID AMINO-ACID PERMEASE TRANSMEMBRANE) protein domain (PD000442) which is seen in O07576_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 13:54:48 2002","Fri Nov 30 15:38:29 2001","Fri Feb 3 09:44:56 2006","Fri Feb 3 09:44:56 2006","Mon Oct 7 14:00:52 2002","Mon Oct 7 14:00:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0014 is paralogously related (blast p-value < 1e-3) to SMu0863, SMu1320, SMu0239, and SMu1909.","Tue Oct 22 13:54:48 2002","","No significant hits to the NCBI PDB database.","SMU.16","Fri Nov 30 15:38:29 2001","Residues 25 to 468 (E-value = 9.3e-24) place SMu0014 in the AA_permease family which is described as Amino acid permease (PF00324)","Mon Oct 7 14:00:52 2002","24378546","","","","","","1","","","SMU.16","" "SMu0015","16624","16761","138","ATGAAACCTTGTCTATCTCTTTACCAAATGATCTCAGTTAAAACAGAAAAAAAGCGAGAAAAGCTATTGACAAAGGGGGGAAGAGCTGGTAGAATAAAGAAGTTGTCTCAGAAAGAGGCAGAGCCCTTTGAAAACTGA","10.80","6.93","5177","MKPCLSLYQMISVKTEKKREKLLTKGGRAGRIKKLSQKEAEPFEN","16758","","hypothetical protein","Extracellular, Periplasm","No hits in gapped BLAST. SMu0015 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 15:13:42 2006","Fri Nov 30 15:45:12 2001","Thu Sep 28 15:13:42 2006","Mon Oct 7 14:01:25 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0015 is paralogously related (blast p-value < 1e-3) to SMu0171.","Thu Sep 28 15:13:42 2006","","No significant hits to the NCBI PDB database.","SMU.18","Fri Nov 30 15:43:25 2001","No significant hits to the Pfam 11.0 database","Mon Oct 7 14:01:25 2002","24378547","","","","","","1","","","SMU.18","" "SMu0016","23655","24464","810","ATGAGATTGTCACGTTTTATTGTTTTTGTTATCACGGTATTATTAACAATTTCAATAGGACTTTTTTTTATTTTCCAAGATTCTGTTATTATAAAATCGGTATCAAAGCCTGTTAATTTAGTTGTTTCTAGCGCTGATGAGATCGTACATTGGCCTTTTCAAGTAATTGATAATACTAAGCATTTGTTTAAAACTAATTCAGAAAATAAAACATTAAAGCGTAAGTTAGAAAAATTTGAGGGGCAAAAAGGTGATTTAGAGAGATTAAAAGAAGAAAACACAGCACTTCGTAAGACTTTAAAAATTAAAGAAAATTTCCCTGATCTAACTGTTTTGTCATCTAAAGTCATTGTTCGTTCCCCGGTTTCTTGGTTAGATATATTAACTATAGATTTAGGAAAAAATGATGGGGTGACAAAAAATATGTTAGTCCTTTCAAATGGTAATTTAGTGGGGAAAATTACTCAAGTTACTGCTACCTCTAGTTCTGTAAAACTGCTTTCCAATACTAAAAGCATTGATGAAATTCCAGTCAAAATTGCAACCCAAAAGGGGGATGTTTTTGGCATTTTAACACATTATGATCCTAAAACCAGTACTTTTGAAATTACTCAATTAACCTCCTCCTTAGATGTTAAGAAAGGGGATAGTGTTACAACAAGTGGCTTAGATGGACAAAGTGTTGAAGGTGTGTCTGTTGGTAAGGTTGTATCTGAAGAAAATAATTCAAACAATCTTTCTCGGAAAATTTTCGTTAAACCAGCGGTAGATTTATCTGATATCTCCCATGTAACTTTAGTAGGTGATTAA","9.90","4.97","29573","MRLSRFIVFVITVLLTISIGLFFIFQDSVIIKSVSKPVNLVVSSADEIVHWPFQVIDNTKHLFKTNSENKTLKRKLEKFEGQKGDLERLKEENTALRKTLKIKENFPDLTVLSSKVIVRSPVSWLDILTIDLGKNDGVTKNMLVLSNGNLVGKITQVTATSSSVKLLSNTKSIDEIPVKIATQKGDVFGILTHYDPKTSTFEITQLTSSLDVKKGDSVTTSGLDGQSVEGVSVGKVVSEENNSNNLSRKIFVKPAVDLSDISHVTLVGD","24461","For other 'mrc' genes see SMu0017 (mreD) and SMu1045 (mreA).","cell shape-determining protein MreC","Membrane, Cytoplasm, Extracellular","This sequence has been previously published in GenBANK as GI:16753177.Matches in gapped BLAST to rod-shape determining proteins. Residues 4-269 are 34% similar to the mreC protein of S.pneumoniae (gi15902022). Residues 1-267 are 32% similar to gi15674213 of L.lactis subsp. lactis.SMu0016 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001809
Family

Borrelia outer surface lipoprotein
PD001127	$\"[78-219]T$	Outrsurface

InterPro
IPR005223
Family

Rod shape-determining protein MreC, subtype
TIGR00219	$\"[1-269]T$	mreC

InterPro
IPR007221
Family

Rod shape-determining protein MreC
PF04085	$\"[114-269]T$	MreC

","BeTs to 7 clades of COG1792COG name: Rod shape-determining protein MreCFunctional Class: MThe phylogenetic pattern of COG1792 is -----q--eb-huj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 121-267 are 36% similar to a (ROD SHAPE-DETERMINING COMPLETE PROTEOME) protein domain (PD011444) which is seen in Q9KI53_ENTFC.Residues 60-222 are 27% similar to a (PROTEOME COMPLETE MREC SHAPE-DETERMINING) protein domain (PD118507) which is seen in Q9ZCH5_RICPR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 14:00:26 2006","Fri Nov 30 15:46:21 2001","Wed Sep 27 14:00:26 2006","Wed Apr 3 08:45:18 2002","","Wed Dec 5 10:25:43 2001","yes","Tue Oct 8 15:59:43 2002","SMu0016 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 12:38:37 2002","","No significant hits to the NCBI PDB database.","SMU.20","Fri Nov 30 15:46:21 2001","Residues 114 to 269 (E-value = 2.4e-41) place SMu0016 in the MreC family which is described as rod shape-determining protein MreC (PF04085)","Wed Dec 5 10:25:43 2001","24378548","","Chia,J.S., Lee,Y.Y., Huang,P.T. and Chen,J.Y.Identification of Stress-Responsive Genes in Streptococcus mutansby Differential Display Reverse Transcription-PCRInfect. Immun. 69 (4), 2493-2501 (2001)PubMed: 11254612Chia,J.S., Chang,L.Y., Shun,C.T., Chang,Y.Y. and Chen,J.Y.A 60-Kilodalton Immunodominant Glycoprotein Is Essential for CellWall Integrity and the Maintenance of Cell Shape in StreptococcusmutansInfect. Immun. 69 (11), 6987-6998 (2001)PubMed: 11598074","Montagne J.Genetic and molecular mechanisms of cell size control.Mol Cell Biol Res Commun. 2000 Oct;4(4):195-202. Review.PMID: 11409911Burger A, Sichler K, Kelemen G, Buttner M, Wohlleben W.Identification and characterization of the mre gene region of Streptomyces coelicolor A3(2).Mol Gen Genet. 2000 Jul;263(6):1053-60.PMID: 10954092Kubo,M., Pierro,D.J., Mochizuki,Y., Kojima,T., Yamazaki,T.,Satoh,S., Takizawa,N. and Kiyohara,H.Bacillus stearothermophilus cell shape determinant gene, mreC andmreD, and their stimulation of protease production in BacillussubtilisBiosci. Biotechnol. Biochem. 60 (2), 271-276 (1996)PubMed: 9063975","Wed Apr 3 08:45:18 2002","Wed Apr 3 08:45:18 2002","1","","","SMU.20","" "SMu0017","24466","24972","507","ATGTCTATCTTTAAAAATAAATTATTTGTCATTTTATTTGCCTTTCTTATGTTACTTGTAGATGGGCATTTATCTTTATTATCACGAATCTTATTTCAAAATCAGTTTATTGTGTCAAGTCATTTTTTATTCATTGTGTTATTGTTTTATACTCTTGTATTCAATCCTTATTTTATTTTTGGACTTGCCTGTGTTTTAGGAATTATTTATGATTTTTATTATTTAGGGGTATATAATTTGGGAATTGCAACTATGTTGTATCCTTTAACAATTGTTATTATGTTTAAATTATGGAAACATATTCCAAATGGTCCTGTTCAACGCTTTCTAGTTTTTTTTATCCTAATCTTTTTTCTTGATTTTGCTAGTATTGGTATGGCCTATTTATATCAATTGACAGCTTATCCTTTAAATGATTTTATCACTTATAATTTAGCACCTTCCTTAATTTTTAATATACTGGCTTTTCTCTTCTTTCAAAAACTTTTAGAAAGGATTTACCTATGA","9.70","3.65","19790","MSIFKNKLFVILFAFLMLLVDGHLSLLSRILFQNQFIVSSHFLFIVLLFYTLVFNPYFIFGLACVLGIIYDFYYLGVYNLGIATMLYPLTIVIMFKLWKHIPNGPVQRFLVFFILIFFLDFASIGMAYLYQLTAYPLNDFITYNLAPSLIFNILAFLFFQKLLERIYL","24969","For other 'mrc' genes see SMu0016 (mreC) and SMu1045 (mreA).For other 'rod' genes see SMu1169 (rodA).","cell shape-determining protein MreD","Membrane, Cytoplasm","This sequence was previously published in GenBANK as gi16753178.Several weakish matches in gapped BLAST to mreD proteins: residues 10-168 are 32% similar to the predicted mreD protein in S.pneumoniae (gi15902021). Residues 1-167 are 32% similar to this protein in Lactococcus (gi15674212).SMu0017 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[10-28]?$ $\"[43-65]?$ $\"[75-95]?$ $\"[110-130]?$ $\"[140-160]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-164 are 28% similar to a (PROTEOME MRED COMPLETE SHAPE) protein domain (PD098799) which is seen in Q9CDJ0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 14:00:43 2006","Wed Dec 5 09:22:17 2001","Wed Sep 27 14:00:43 2006","Wed Dec 5 09:22:17 2001","","Wed Dec 5 09:22:17 2001","yes","Tue Oct 8 16:00:47 2002","No significant paralogous sequences. Residues 13-159 are 28% similar to residues 334-476 of SMu0568, a predicted competance protein (E = 6e-04).SMu0017 is paralogously related (blast p-value < 1e-3) to SMu0568.","Wed Dec 19 15:09:44 2001","","No significant hits to the NCBI PDB database.","SMU.21","","Residues 2 to 166 (E-value = 9.7e-06) place SMu0017 in the MreD family which is described as rod shape-determining protein MreD (PF04093)","Wed Dec 5 09:22:17 2001","24378549","","Chia,J.S., Lee,Y.Y., Huang,P.T. and Chen,J.Y.Identification of Stress-Responsive Genes in Streptococcus mutansby Differential Display Reverse Transcription-PCRInfect. Immun. 69 (4), 2493-2501 (2001)PubMed: 11254612Chia,J.S., Chang,L.Y., Shun,C.T., Chang,Y.Y. and Chen,J.YA 60-Kilodalton Immunodominant Glycoprotein Is Essential for CellWall Integrity and the Maintenance of Cell Shape in StreptococcusmutansInfect. Immun. 69 (11), 6987-6998 (2001)PubMed: 11598074","Kubo,M., Pierro,D.J., Mochizuki,Y., Kojima,T., Yamazaki,T.,Satoh,S., Takizawa,N. and Kiyohara,H.Bacillus stearothermophilus cell shape determinant gene, mreC andmreD, and their stimulation of protease production in BacillussubtilisBiosci. Biotechnol. Biochem. 60 (2), 271-276 (1996)PubMed: 9063975.Burger A, Sichler K, Kelemen G, Buttner M, Wohlleben W.Identification and characterization of the mre gene region of Streptomyces coelicolor A3(2).Mol Gen Genet. 2000 Jul;263(6):1053-60.PMID: 10954092.","Wed Apr 3 08:46:12 2002","Wed Apr 3 08:46:12 2002","1","","","SMU.21","" "SMu0018","25082","26377","1296","ATGAAAAAAAGAATTTTATCAGCAGTTTTAGTGAGTGGTGTAACTCTTAGTTCTGCGACAACATTATCAGCTGTAAAAGCTGATGACTTTGATGCGCAGATTGCGTCACAAGATTCTAAAATCAACAACTTGACCGCACAACAGCAAGCAGCACAAGCACAAGTTAATACGATTCAAGGACAAGTAAGTGCTTTACAGACACAACAAGCTGAATTACAAGCTGAAAATCAAAGACTTGAAGCTCAGTCTGCTACTTTGGGTCAACAAATTCAAACACTTTCAAGCAAAATTGTTGCACGTAATGAATCTTTGAAGCAACAAGCTCGTAGTGCTCAAAAAAGTAACGCAGCTACCAGCTATATTAATGCTATCATTAATTCAAAATCAGTTTCTGATGCTATTAATCGTGTTTCGGCTATTCGTGAAGTTGTATCTGCTAATGAAAAAATGCTTCAACAACAAGAGCAAGATAAAGCAGCTGTTGAGCAAAAGCAACAAGAAAATCAAGCAGCAATTAATACTGTTGCAGCTAATCAGGAGACAATTGCTCAAAATACAAATGCTTTAAATACACAGCAAGCTCAATTAGAAGCAGCACAACTAAACTTGCAAGCTGAATTGACTACTGCACAAGATCAAAAAGCTACTTTAGTTGCTCAAAAAGCGGCAGCAGAGGAAGCTGCACGCCAAGCAGCAGCAGCACAAGCGGCAGCAGAAGCTAAGGCCGCAGCAGAAGCGAAAGCTTTACAAGAACAAGCAGCGCAAGCACAAGCAGCAGCAAATAATAATACTCAAGCTACAGATGTTTCTGACCAACAAGCAGCGGCAGCTGATAACACTCAAGCAGCACAAACAGGTGATTCAACTGAGCAGTCAGCAGCACAAGCAGTAAATAATTCTGATCAAGAAAGTACTACAGCAACAGAAGCACAACCATCAGCTTCTAGTGCTTCGACAGCTGCTGTAGCAGCTAATACTTCTTCTGCTAATACATATCCAGCAGGGCAATGTACTTGGGGTGTTAAATCATTAGCTCCTTGGGTAGGAAACTACTGGGGTAATGGTGGACAATGGGCAGCAAGTGCAGCAGCGGCAGGATATAGAGTTGGTTCTACACCTTCAGCTGGAGCTGTAGCTGTATGGAATGATGGCGGTTATGGACACGTTGCTTATGTTACAGGTGTTCAAGGTGGCCAAATTCAAGTTCAAGAAGCTAACTATGCAGGTAACCAATCTATTGGTAACTACCGTGGTTGGTTTAATCCAGGTAGTGTAAGCTATATCTATCCAAACTAA","4.70","-8.79","44608","MKKRILSAVLVSGVTLSSATTLSAVKADDFDAQIASQDSKINNLTAQQQAAQAQVNTIQGQVSALQTQQAELQAENQRLEAQSATLGQQIQTLSSKIVARNESLKQQARSAQKSNAATSYINAIINSKSVSDAINRVSAIREVVSANEKMLQQQEQDKAAVEQKQQENQAAINTVAANQETIAQNTNALNTQQAQLEAAQLNLQAELTTAQDQKATLVAQKAAAEEAARQAAAAQAAAEAKAAAEAKALQEQAAQAQAAANNNTQATDVSDQQAAAADNTQAAQTGDSTEQSAAQAVNNSDQESTTATEAQPSASSASTAAVAANTSSANTYPAGQCTWGVKSLAPWVGNYWGNGGQWAASAAAAGYRVGSTPSAGAVAVWNDGGYGHVAYVTGVQGGQIQVQEANYAGNQSIGNYRGWFNPGSVSYIYPN","26374","For other 'gbp' genes see SMu1916 (gbp); SMu0760 (gbpB) and SMu1273 (gbpC).Note tandem repeats at 25829,25862.","glucan-binding protein B","Extracellular, Periplasm","This sequence was previously published in GenBank (gi12802877, gi15341180) and defined as a immunodominant glycoprotein IDG-60; general stress protein GSP-781, or glucan binding protein B.This sequence is similar to Spy0019.Residues 1-431 are 60% similar to the PcsB protein of Streptococcus agalactiae (gi12667037). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0017 (2e-52).","

InterPro
IPR007921
Domain

Cysteine, histidine-dependent amidohydrolase/peptidase
PF05257	$\"[317-429]T$	CHAP
PS50911	$\"[312-429]T$	CHAP

InterPro
IPR009148
Family

Streptococcal non-M secreted SibA
PR01852	$\"[214-241]T$ $\"[332-354]T$ $\"[357-381]T$ $\"[399-422]T$	SIBAPROTEIN

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 33-182 are 36% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in Q9K2J9_ENTFC.Residues 332-391 are 44% similar to a (PRECURSOR SIGNAL PLASMID SECRETED) protein domain (PD012961) which is seen in O54487_STACA.Residues 86-177 are 34% similar to a (PSPA2 TRXB-HISI) protein domain (PD357879) which is seen in YVCE_BACSU.Residues 1-166 are 38% similar to a (PROTEOME USP45 COMPLETE SECRETED) protein domain (PD075436) which is seen in Q9CDJ1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:04:03 2007","Fri Sep 1 16:26:05 2006","Fri Feb 3 09:54:13 2006","Wed Dec 5 10:26:35 2001","","Wed Dec 5 10:26:35 2001","yes","Tue Oct 8 16:04:13 2002","SMu0018 is similar to SMu0332 and to SMu0760. Weaker similarities are seen to SMu0176, SMu0556, SMu0827 and others. Residues 220-431 are 41% similar to residues 7-211 of SMu0332, a hypothetical that may be a transglycosylase. Residues 300-431 are 50% similar to residues 412-544 of SMu0760, also a hypothetical.SMu0018 is paralogously related (blast p-value < 1e-3) to SMu0332, SMu0760, SMu0176, SMu0556, SMu0827, SMu0215, SMu1935, SMu0676, SMu1375, SMu1273, SMu0555, and SMu0999.","Wed Jan 9 12:43:57 2002","","No significant hits to the NCBI PDB database.","SMU.22","","Residues 317 to 429 (E-value = 3.5e-43) place SMu0018 in the CHAP family which is described as CHAP domain (PF05257)","Wed Dec 5 10:26:35 2001","24378550","","Chia,J.S., Lee,Y.Y., Huang,P.T. and Chen,J.Y.Identification of Stress-Responsive Genes in Streptococcus mutansby Differential Display Reverse Transcription-PCRInfect. Immun. 69 (4), 2493-2501 (2001)PubMed: 11254612 Chia,J.S., Chang,L.Y., Shun,C.T., Chang,Y.Y. and Chen,J.Y.A 60-Kilodalton Immunodominant Glycoprotein Is Essential for CellWall Integrity and the Maintenance of Cell Shape in StreptococcusmutansInfect. Immun. 69 (11), 6987-6998 (2001)PubMed: 11598074Jin,S., Duncan,M.J., Taubman,M.A. and Smith,D.J.Cloning of the gbpB gene from Streptococcus mutansJ. Dent. Res. 79, 224-224 (2000)Mattos-Graner,R.O., Jin,S., King,W.F., Chen,T., Smith,D.J. andDuncan,M.J.Cloning of the Streptococcus mutans Gene Encoding Glucan BindingProtein B and Analysis of Genetic Diversity and Protein Productionin Clinical IsolatesInfect. Immun. 69 (11), 6931-6941 (2001)PubMed: 11598068Peacock ZS, Barnes LA, King WF, Trantolo DJ, Wise DL, Taubman MA, Smith DJ.Influence of microparticle formulation on immunogenicity of SYI, a synthetic peptide derived from Streptococcus mutans GbpB.Oral Microbiol Immunol. 2005 Feb;20(1):60-4.PMID: 15612949","","Fri Feb 3 09:54:13 2006","","1","","","SMU.22","215" "SMu0019","26502","27470","969","ATGTCTTATTCTAATTTAAAATTGTTTGCTTTATCTTCAAACAAAGAATTAGCAGAGAAAGTGGCTAAGACTATTGGTATTAGTCTTGGAAAATCAACTGTTCGTCAATTTTCTGATGGAGAAATTCAAGTTAATATTGAAGAATCTATTCGCGGAAACCATGTTTTTATTTTACAGTCAACAAGTTCACCTGTAAATGATAACTTAATGGAAATTTTGATTATGGTTGATGCTCTTAAACGTGCTAGTGCTGAGACTGTCAGTGTTGTCATGCCTTATTATGGTTATGCTCGTCAAGATCGAAAAGCACGTTCGCGTGAACCCATCACCTCCAAGTTAGTTGCTAATATGCTTGCTGTGGCGGGAGTTGATCGTCTTTTGACTGTTGACTTGCATGCAGCACAAATTCAAGGTTTTTTTGATATTCCTGTTGATCATTTGATGGGAGCCCCTTTAATTGCGGATTATTTTGTTCGTCGTGGTATGTGTGGCAGCGACTATGTCGTTGTTAGTCCTGACCATGGAGGCGTGACACGTGCGCGTAAATTAGCCCAATTTCTTCAAACTCCGATAGCAATTATTGATAAACGACGAAATGTTAACAAAATGAATACAAGTGAAGTCATGAATATCATTGGCAATGTTTCTGGGAAAACGTGTATTTTAATTGATGATATGATTGATACTGCAGGAACAATTGCTCATGCAGCTGACGCCCTTGCTGAAGCAGGTGCTACTGCAGTTTATGCTTCATGTACACATCCAGTTCTGTCTGGTTCTGCTTTAGATAATATTCAAAATTCGGCTATTGAAAAATTAGTTGTTTTGGATACAATTGACCTTCCTGAAGAAAAATTGATAGATAAAATTGAACAAATTTCAATTACTGATTTGATTTCTGAGGCTATTATTCGTATTCATGAAAAACGACCGCTATCACCTTTATTTGAATTTACAACTTTTAACTAG","5.90","-4.44","35160","MSYSNLKLFALSSNKELAEKVAKTIGISLGKSTVRQFSDGEIQVNIEESIRGNHVFILQSTSSPVNDNLMEILIMVDALKRASAETVSVVMPYYGYARQDRKARSREPITSKLVANMLAVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFVRRGMCGSDYVVVSPDHGGVTRARKLAQFLQTPIAIIDKRRNVNKMNTSEVMNIIGNVSGKTCILIDDMIDTAGTIAHAADALAEAGATAVYASCTHPVLSGSALDNIQNSAIEKLVVLDTIDLPEEKLIDKIEQISITDLISEAIIRIHEKRPLSPLFEFTTFN","27467","For other 'prs' genes see SMu0958 (prsA),(prs).","phosphoribosyl pyrophosphate synthetase (PRPP synthetase)","Cytoplasm, Membrane","Several matches in gapped BLAST to PRPP sequences, for instance residues 1-317 are 91% similar to the enzyme in S.pyogenes (gi15674264) and 87% similar to the enzyme in S.pneumoniae (gi15902072).See Spy0020.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0018 (1e-152).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[141-274]T$	Pribosyltran

InterPro
IPR000842
Family

Phosphoribosyl pyrophosphate synthetase
PS00114	$\"[130-145]T$	PRPP_SYNTHETASE

InterPro
IPR002375
Family

Purine/pyrimidine phosphoribosyl transferase
PS00103	$\"[220-232]F$	PUR_PYR_PR_TRANSFER

InterPro
IPR005946
Family

Ribose-phosphate pyrophosphokinase
TIGR01251	$\"[6-317]T$	ribP_PPkin

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2020	$\"[4-172]T$	G3DSA:3.40.50.2020
PTHR10210	$\"[1-321]T$	PTHR10210
PTHR10210:SF14	$\"[1-321]T$	PTHR10210:SF14
SSF53271	$\"[71-310]T$	SSF53271

","BeTs to 15 clades of COG0462COG name: Phosphoribosylpyrophosphate synthetaseFunctional Class: F,EThe phylogenetic pattern of COG0462 is AmtkYqvcebrhujgpol---Number of proteins in this genome belonging to this COG is 2","***** IPB000842 (Phosphoribosyl pyrophosphate synthetase) with a combined E-value of 5.6e-121. IPB000842A 36-78 IPB000842B 106-151 IPB000842C 166-193 IPB000842D 196-250 IPB000842E 253-280 IPB000842F 293-316***** IPB002375 (Purine/pyrimidine phosphoribosyl transferase) with a combined E-value of 5.8e-06. IPB002375B 217-232","Residues 36-218 are 30% similar to a (PROTEOME PHOSPHORIBOSYL TRANSFERASE) protein domain (PD102473) which is seen in O51494_BORBU.Residues 6-218 are 69% similar to a (TRANSFERASE PYROPHOSPHOKINASE RIBOSE-PHOSPHATE) protein domain (PD001439) which is seen in O33924_CORAM.Residues 8-202 are 29% similar to a (TRANSFERASE PHOSPHORIBOSYL SYNTHASE) protein domain (PD306086) which is seen in Q9XGA1_SPIOL.Residues 5-218 are 42% similar to a (TRANSFERASE PHOSPHORIBOSYLPYROPHOSPHATE) protein domain (PD035825) which is seen in Q9VT33_DROME.Residues 280-317 are 63% similar to a (PROTEOME COMPLETE KINASE RIBOSE-PHOSPHATE) protein domain (PD378133) which is seen in Q9CHB8_LACLA.Residues 221-303 are 27% similar to a (PROTEOME COMPLETE PYROPHOSPHOKINASE) protein domain (PD413639) which is seen in O29666_ARCFU.Residues 221-279 are 44% similar to a (PYROPHOSPHOKINASE RIBOSE-PHOSPHATE) protein domain (PD375317) which is seen in KPRS_SALTY.Residues 220-279 are 65% similar to a (TRANSFERASE SYNTHETASE PHOSPHORIBOSYL PYROPHOSPHOKINASE) protein domain (PD016748) which is seen in Q9CHB8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:07:05 2007","Wed Dec 5 11:32:30 2001","Fri Feb 3 10:02:15 2006","Wed Apr 3 09:03:39 2002","Wed Dec 5 11:32:30 2001","Wed Dec 5 11:32:30 2001","yes","Fri Feb 20 15:41:32 MST 1998","This protein is highly similar to SMu0958, also a predicted PRPP. Residues 5-318 are 53% similar to SMu0958.SMu0019 is paralogously related (blast p-value < 1e-3) to SMu0958.","Wed Jan 9 12:45:46 2002","Fri Feb 3 10:02:15 2006","pdb1DKRB Chain B, Crystal Structures Of Bacillus Subtilis Pho... 391 7e-110","SMU.23","","Residues 141 to 274 (E-value = 9.9e-35) place SMu0019 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Wed Dec 5 11:32:30 2001","24378551","","","Drouault S, Anba J, Bonneau S, Bolotin A, Ehrlich SD, Renault P. The peptidyl-prolyl isomerase motif is lacking in PmpA, the PrsA-like protein involved in the secretion machinery of Lactococcus lactis.Appl Environ Microbiol. 2002 Aug;68(8):3932-42.PMID: 12147493 Nilsson,D., Hove-Jensen,B. and Arnvig,K.Primary structure of the tms and prs genes of Bacillus subtilisMol. Gen. Genet. 218 (3), 565-571 (1989)PubMed: 2555671Eriksen,T.A., Kadziola,A., Bentsen,A.K., Harlow,K.W. and Larsen,S.Structural basis for the function of Bacillus subtilisphosphoribosyl-pyrophosphate synthetaseNat. Struct. Biol. 7 (4), 303-308 (2000)PubMed: 10742175","","Fri Oct 25 13:25:10 2002","1","","","SMU.23","216" "SMu0020","27559","28734","1176","ATGGATTTGAGTAAACGTTTTAATAAAAATTTAAATAAGATTGAAGTCTCTATGATTCGTCAGTTTGATCAATCTATTTCAGATATTCCAGATGTTTTGAAATTGACTTTGGGTGAACCAGATTTTGCAACTCCAAAACATATTAAGGAGGCTGCTAAAAGGGCAATTGATGCTGATGAAAGTCATTACACAGGAATGGCAGGACTTTTGGCATTAAGGCAGGCAGCTAGTGCTTTTGTAAAAGAAAAATATCATCTTACCTATAATCCTGATAATGAAATTTTAGTAACAATTGGAGCTACAGAAGCTTTATCAGCTAGTTTAACAGCTATTTTGGAACCTGGTGATAAAGTGCTTTTGCCTGCACCAGCTTATCCCGGTTATGAGCCTGTTGTTAATTTGGTTGGGGCTGAAGTAGTTGAGATTGATACCAGATCTAATGATTTTGTCCTAACACCAGAGATGCTTGAAGAGGCTATTTTAAAAGAGGGAGAGGCTCTTAAGGCTGTTATTCTCAACTATCCAACCAACCCAACAGGAGTAACTTATTCGCGCCAGCAAATCAAAAATTTGGCTGAGGTTCTTAAAAAATATCCTATCTTTGTCATCAGTGATGAAGTTTATGCTGAACTGACTTATACAGGAGAATCACACGTTTCTATTGCTGAATATTTACCTGACCAAACGATTTTGATTTCTGGTTTATCGAAATCACATGCCATGACAGGTTGGCGTTTGGGCTTGATTTTTGCACCAGCTGTTTTGACAGCACAGTTGATTAAGAGTCATCAGTATTTGGTAACTGCAGCGACCACCAGTGTACAATTTGCTGCTATAGAAGCTTTGACCAATGGTAAAGATGATGCTCTGCCAATGAAAGAAGAATATATTAAGCGCCGTGATTATATCATTGAAAAAATGGAAGCAATGAAGTTTAAAATCATCAAACCTGATGGTGCTTTTTATATCTTTGCTAAAATACCAGTTGCGCAAGGACAAGATTCCTTTAAGTTCCTACAAGATTTTGCTAAAGAGAAGGCAGTAGCTTTTATTCCTGGTGTTGCTTTTGGAAAATATGGAGAAGGTTACTTACGAATTTCTTATGCAGCAAGCATGGAGACTATAAAAGAAGCGATGAAACGCCTTAAAGAATTTATGGAGCAATATGCAGACTAA","5.30","-7.52","43447","MDLSKRFNKNLNKIEVSMIRQFDQSISDIPDVLKLTLGEPDFATPKHIKEAAKRAIDADESHYTGMAGLLALRQAASAFVKEKYHLTYNPDNEILVTIGATEALSASLTAILEPGDKVLLPAPAYPGYEPVVNLVGAEVVEIDTRSNDFVLTPEMLEEAILKEGEALKAVILNYPTNPTGVTYSRQQIKNLAEVLKKYPIFVISDEVYAELTYTGESHVSIAEYLPDQTILISGLSKSHAMTGWRLGLIFAPAVLTAQLIKSHQYLVTAATTSVQFAAIEALTNGKDDALPMKEEYIKRRDYIIEKMEAMKFKIIKPDGAFYIFAKIPVAQGQDSFKFLQDFAKEKAVAFIPGVAFGKYGEGYLRISYAASMETIKEAMKRLKEFMEQYAD","28731","","aspartate or aromatic amino acid aminotransferase","Cytoplasm","Several matches in gapped BLAST to aminotransferases. Residues 1-388 are 70% similar to gi15902079 of S.pneumoniae. Residues 1-386 are 68% similar to a predicted aromatic aminotransferase from Lactococcus (gi6318592).This sequence is similar to Spy0650.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0019 (1e-173).","

InterPro
IPR001176
Family

1-aminocyclopropane-1-carboxylate synthase
PR00753	$\"[93-113]T$ $\"[115-136]T$ $\"[164-188]T$ $\"[200-223]T$	ACCSYNTHASE

InterPro
IPR004838
Binding_site

Aminotransferases class-I pyridoxal-phosphate-binding site
PS00105	$\"[234-247]T$	AA_TRANSFER_CLASS_1

InterPro
IPR004839
Domain

Aminotransferase, class I and II
PF00155	$\"[30-382]T$	Aminotran_1_2

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[44-285]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[5-380]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[47-391]T$	PTHR11751
PTHR11751:SF35	$\"[47-391]T$	PTHR11751:SF35

InterPro
IPR003717
Family

Recombination protein O, RecO
PIRSF026498	$\"[2-248]T$	RecO
PF02565	$\"[1-246]T$	RecO
TIGR00613	$\"[4-243]T$	reco

","BeTs to 3 clades of COG1381COG name: Recombination protein RecOFunctional Class: LThe phylogenetic pattern of COG1381 is -------cebrh-----lin-Number of proteins in this genome belonging to this COG is 1","***** IPB003717 (Recombination protein O (RecO)) with a combined E-value of 1.6e-06. IPB003717A 9-27 IPB003717B 92-143 IPB003717D 231-240","Residues 155-241 are 58% similar to a (DNA REPAIR RECOMBINATION PROTEOME) protein domain (PD116235) which is seen in RECO_LACLA.Residues 1-154 are 51% similar to a (DNA REPAIR RECOMBINATION) protein domain (PD398488) which is seen in RECO_LACLA.Residues 10-153 are 28% similar to a (DNA REPAIR RECOMBINATION PROTEOME) protein domain (PD008539) which is seen in RECO_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 1 17:03:26 2006","Fri Sep 1 17:03:26 2006","Fri Feb 3 10:06:50 2006","Wed Apr 3 09:09:30 2002","Wed Dec 5 12:39:39 2001","Wed Dec 5 12:39:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0021 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Apr 3 09:09:30 2002","","No significant hits to the NCBI PDB database.","SMU.25","","Residues 1 to 244 (E-value = 9.1e-19) place SMu0021 in the RecO family which is described as Recombination protein O (PF02565)","Wed Dec 5 12:39:39 2001","24378553","","","Fernandez S, Kobayashi Y, Ogasawara N, Alonso JC.Analysis of the Bacillus subtilis recO gene: RecO forms part of the RecFLOR function.Mol Gen Genet. 1999 Apr;261(3):567-73.PMID: 10323239Shan Q, Bork JM, Webb BL, Inman RB, Cox MM.RecA protein filaments: end-dependent dissociation from ssDNA and stabilization by RecO and RecR proteins.J Mol Biol. 1997 Feb 7;265(5):519-40.PMID: 9048946 ","","Wed Dec 5 12:49:34 2001","1","","","SMU.25","218" "SMu0022","29687","30685","999","ATGAAGAAAATTGCAGTTGATGCTATGGGTGGAGACAATGCCCCTCAAGCTATTGTCGAAGGAGTTAATCAGGCTTTAGCAGATTTTTCAGATATTGAAATTCAACTCTATGGTGATGAAGCAAAAATAAAGACTTATTTAAAAGCAAATGATCGTGTGTCTATTATCCATACGGATGAAAAAATTAATTCAGATGATGAACCTGTAAAGGCTATTCGAAAGAAAAAACAGGCTTCAATGGTTTTAGGAGCACAGGCTGTTAAAGATGGTAAGGCTGATGCAGTTCTTTCTGCTGGGAATACAGGAGCTTTGCTAGCTGCTGGACTTCTTGTTGTTGGACGTATCAAAAATATTGACCGTCCTGGTTTGATGTCATCACTTCCTACGATTGATGGTAAAGGATTTAATATGCTTGATTTAGGAGCTAATGCTGAAAATACAGCTCATCATTTGCATCAATATGCTATTCTTGGCTCTTTTTATGCTAAGAATGTCAGAGGCGTTGCTCATCCGCGGATTGGTCTACTTAATAATGGTACAGAAACAACTAAAGGAGATCCACTGCGTAAAGAAACCTTTGCTCTTTTAGCAGCAGATGAAACCCTCAATTTTATAGGAAATGTTGAAGCGCGCGATTTGATGAACAGTGTCGCAGATGTTGTTGTAACAGATGGTTTCACGGGAAACGCTGTTTTGAAATCCATTGAAGGGACAGCACTTGGCATTATGGAACAGCTGAAAACGTCCATTAAGCAAGCTGGTTTAAGAGCAAAATTAGGAGCTCTTTTACTCAAAAATAGTCTTTATGATTTGAAAGATTCTTTGGATTATTCAGGTGCAGGCGGGGCTGTACTTTTTGGACTTAAGGCTCCTGTTGTTAAATGTCATGGTTCAAGTGATGCTAAATCTGTTTACTACACTATTAAGCAAATCCGAATCATGCTTGAAACTGATGTTGTTGGTCAATTAGTAGAAGAATTTTCAAACAGGGGGGACTAA","6.80","-0.59","35281","MKKIAVDAMGGDNAPQAIVEGVNQALADFSDIEIQLYGDEAKIKTYLKANDRVSIIHTDEKINSDDEPVKAIRKKKQASMVLGAQAVKDGKADAVLSAGNTGALLAAGLLVVGRIKNIDRPGLMSSLPTIDGKGFNMLDLGANAENTAHHLHQYAILGSFYAKNVRGVAHPRIGLLNNGTETTKGDPLRKETFALLAADETLNFIGNVEARDLMNSVADVVVTDGFTGNAVLKSIEGTALGIMEQLKTSIKQAGLRAKLGALLLKNSLYDLKDSLDYSGAGGAVLFGLKAPVVKCHGSSDAKSVYYTIKQIRIMLETDVVGQLVEEFSNRGD","30682","","fatty acid/phospholipid synthesis protein","Cytoplasm","Several matches in gapped BLAST to plsX proteins. Residues 1-328 are 82% similar to gi15902081 of S.pneumoniae and are 74% similar to gi15674266 of S.pyogenes.See Spy0022.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0022 (1e-130).","

InterPro
IPR003664
Family

Fatty acid synthesis plsX protein
PD006974	$\"[51-123]T$	FA_synthesis
PF02504	$\"[2-322]T$	FA_synthesis
TIGR00182	$\"[2-332]T$	plsX

InterPro
IPR012281
Family

Phospholipid biosynthesis protein, PlsX type
PIRSF002465	$\"[2-332]T$	Phsphlp_syn_PlsX

noIPR
unintegrated

unintegrated
SSF53659	$\"[1-329]T$	SSF53659

","BeTs to 8 clades of COG0416COG name: Fatty acid/phospholipid biosynthesis enzymeFunctional Class: IThe phylogenetic pattern of COG0416 is -----qvceb--ujgp--in-Number of proteins in this genome belonging to this COG is 1","***** IPB003664 (Fatty acid synthesis plsX protein) with a combined E-value of 1.3e-72. IPB003664A 2-25 IPB003664B 98-128 IPB003664C 171-185 IPB003664D 204-237 IPB003664E 274-311","Residues 3-327 are 52% similar to a (FATTY BIOSYNTHESIS ACID/PHOSPHOLIPID) protein domain (PD006974) which is seen in PLSX_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 14:41:10 2002","Wed Apr 24 12:57:23 2002","Fri Feb 3 10:14:54 2006","Wed Apr 24 12:57:23 2002","Wed Dec 5 12:50:42 2001","Wed Dec 5 12:50:42 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0022 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Apr 24 12:57:23 2002","","No significant hits to the NCBI PDB database.","SMU.26","","Residues 2 to 322 (E-value = 3.3e-129) place SMu0022 in the FA_synthesis family which is described as Fatty acid synthesis protein (PF02504)","Wed Dec 5 12:50:42 2001","24378554","","","","","","1","","","SMU.26","219" "SMu0023","30687","30935","249","ATGACTAATGAAGAGATTTTTGACAGGATTTCTAATCTCATTAAAGAACAGCTGCACAATGAAAAAATAGAAGTTACTGTGAAGACCAATATTCAAGAGGACTTAGGAATTGATTCCATTGCACTTATGGAGTTTATCATTACGCTTGAAGATGAATTTAATCTGAACATTCCTGATGAAGATGTGGAAGATATTCAGACCATGGGAGAATTAGTCGACTATCTTTCTAGGCGTTTAAAGAGTTCTTAG","4.00","-12.76","9540","MTNEEIFDRISNLIKEQLHNEKIEVTVKTNIQEDLGIDSIALMEFIITLEDEFNLNIPDEDVEDIQTMGELVDYLSRRLKSS","30932","For other 'acp' genes see SMu1589 (acp);SMu1671 (acpS) and SMu1376 (acpA). ","acyl carrier protein","Cytoplasm","Matches in gapped BLAST to acyl carrier proteins. Residues 1-79 are 50% similar to the ACP from S.pyogenes (gi15674267). Residues 1-72 are 47% similar to the ACP from S.pneumoniae (gi15899984).See Spy0023.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0023 (6e-17).","

InterPro
IPR003231
Family

Acyl carrier protein (ACP)
PD000887	$\"[34-74]T$	Acyl_carrier
TIGR00517	$\"[3-79]T$	acyl_carrier

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[8-75]T$	PP-binding
PS50075	$\"[6-76]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[1-75]T$	ACP_like
SSF47336	$\"[1-79]T$	ACP_like

noIPR
unintegrated

unintegrated
PTHR20863	$\"[1-79]T$	PTHR20863

","BeTs to 13 clades of COG0236COG name: Acyl carrier proteinFunctional Class: IThe phylogenetic pattern of COG0236 is ----yqVceBRhUjgpolinxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 5-70 are 46% similar to a (ACYL CARRIER PHOSPHOPANTETHEINE FATTY) protein domain (PD000887) which is seen in Q9F7T4_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 3 10:17:15 2006","Wed Dec 5 13:00:50 2001","Fri Feb 3 10:17:15 2006","Wed Apr 3 10:54:44 2002","","Wed Dec 5 13:00:50 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0023 is weakly similar to SMu1589, a predicted ACP. Residues 6-80 are 32% similar to SMu1589.SMu0023 is paralogously related (blast p-value < 1e-3) to SMu1589.","Wed Apr 3 10:54:44 2002","Fri Feb 3 10:17:15 2006","pdb1ACP Acyl Carrier Protein (Nmr, 2 Structures) 61 2e-011","SMU.27","","Residues 8 to 75 (E-value = 4.6e-16) place SMu0023 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)","Wed Dec 5 13:00:50 2001","24378555","","","Xu GY, Tam A, Lin L, Hixon J, Fritz CC, Powers R.Solution structure of B. subtilis acyl carrier protein.Structure (Camb). 2001 Apr 4;9(4):277-87.PMID: 11525165 ","","Wed Dec 5 13:09:03 2001","1","","","SMU.27","993" "SMu0024","31163","31744","582","ATGGGGAAAAGTGGTTCTGGAAAGACAACTTTGGCAAAAATTCTTGCAGGCTATTATACTGTTAGTAGCGGTGACTCTTTCTTAGATGGAGAAAAGATAAATTATTCCCAGCTGCGCCAATTAGTAACTTATGTGCCACAGCAGTCTTATGTTTTTACAGGAACAATCTTAGATAATCTGCTTCTTGGTGCTGAAGAGGAAGTAACGGATGATCGCTTAATGGAAGTTTGTTCAATTGCTGAAATTTTAGACAATATCAAGGCAATGCCTTTAGGTTTTCAAACACAGATTTCAGAAGACGGCGGTTTATCTGGTGGTCAAAAACAGCGTTTAGCTATTGCACGTGCTCTCTTAACCAGACAGCCTGTGTTGATTTTTGATGAGGCAACTAGTGGTTTAGATCGTGATACCGAAGAAAAAGTTATTGCCAATTTATCTAAATTGGAGCGCACGATTATTTTTATTGCTCACCGAGGCAGTGTTTCTTATTATGCTGATCGAATTGTTGAGATTGACTCTGGAGAGAAAATTAAGGATAGAATAAATCATCGTCCTTTCTCATTTTTGATGATGACTCTTTGA","5.00","-4.56","21373","MGKSGSGKTTLAKILAGYYTVSSGDSFLDGEKINYSQLRQLVTYVPQQSYVFTGTILDNLLLGAEEEVTDDRLMEVCSIAEILDNIKAMPLGFQTQISEDGGLSGGQKQRLAIARALLTRQPVLIFDEATSGLDRDTEEKVIANLSKLERTIIFIAHRGSVSYYADRIVEIDSGEKIKDRINHRPFSFLMMTL","31741","","ABC transporter, ATP-binding protein","Membrane, Cytoplasm, Extracellular","This sequence corresponds to the previously sequenced gi9802002, gi4103630, gi15625442, gi4098078, gi9802355, gi153741, gi282320, gi547928, gi15625431, gi15625436, gi9802352, gi5918764, and other Mut-related sequences in GenBank. See, e.g. SMu0805.Matches in gapped BLAST to comA and ATP binding proteins. Residues 1-189 are 66% similar to an ABC transporter in S. salivarius (gi3850209). Residues 1-178 are 51% similar to residues 331-512 of a predicted comA protein from S.gordonii (gi1698421).This sequence is similar to Spy0230 and Spy0229.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0460 (1e-28).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[103-145]T$	ABC_transporter
PF00005	$\"[1-174]T$	ABC_tran
PS00211	$\"[103-117]T$	ABC_TRANSPORTER_1
PS50893	$\"[1-193]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[1-175]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-177]T$	G3DSA:3.40.50.300
PTHR19242	$\"[2-177]T$	PTHR19242
PTHR19242:SF91	$\"[2-177]T$	PTHR19242:SF91
SSF52540	$\"[1-177]T$	SSF52540

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.4e-26. IPB001140B 100-138 IPB001140C 151-180","Residues 38-101 are 45% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760) which is seen in Q9EZB0_BACCO.Residues 32-101 are 48% similar to a (TRANSPORT ATP-BINDING LACTOCOCCIN) protein domain (PD402967) which is seen in COMA_STRPN.Residues 1-117 are 29% similar to a (ABC TRANSPORTER) protein domain (PD241124) which is seen in Q9U0N4_PLAF7.Residues 38-100 are 44% similar to a (TRANSPORTER SUBLANCIN ATP-BINDING) protein domain (PD336499) which is seen in Q9XDS0_BBBBB.Residues 38-101 are 50% similar to a (TRANSPORT ATP-BINDING ABC TRANSPORTER) protein domain (PD306522) which is seen in Q48868_LACSK.Residues 42-101 are 70% similar to a (ATP-BINDING TRANSPORT COMPLETE ABC) protein domain (PD333091) which is seen in Q9ZI23_STRSL.Residues 103-145 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9ZI23_STRSL.Residues 103-141 are 69% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459) which is seen in MDR1_LEIEN.Residues 1-172 are 24% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD316735) which is seen in Q9PPY0_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:08:01 2007","Thu Oct 24 13:50:32 2002","Fri Feb 3 10:24:33 2006","Tue Apr 2 11:03:39 2002","Wed Dec 5 13:11:13 2001","Wed Dec 5 13:11:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0024 is similar to SMu1710, SMu0258 and many other ATP binding proteins. Residues 1-188 are 48% similar to residues 563-759 of SMu1710, a predicted ABC transporter.SMu0024 is paralogously related (blast p-value < 1e-3) to SMu1710, SMu0258, SMu1724, SMu0475, SMu1065, SMu1064, SMu0987, SMu0836, SMu0824, SMu0837, SMu0825, SMu0986, SMu0476, SMu1380, SMu1079, SMu0594, SMu0731, SMu1246, SMu1231, SMu0786, SMu0884, SMu0971, SMu1950, SMu1751, SMu1288, SMu0235, SMu0916, SMu0805, SMu1068, SMu1001, SMu1003, SMu0390, SMu1410, SMu0418, SMu1920, SMu0517, SMu1762, SMu0218, SMu0849, SMu0823, SMu1757, SMu1517, SMu1949, SMu1428, SMu1210, SMu0335, SMu1023, SMu1306, SMu1316, SMu0950, SMu0596, SMu1649, SMu1036, SMu1545, SMu0752, SMu0164, SMu0976, SMu1518, SMu1811, SMu1037, SMu0216, SMu0224, SMu1093, SMu0234, SMu0907, SMu0729, SMu0944, SMu1959, SMu0666, SMu1686, and SMu1050.","Wed Jan 9 13:03:11 2002","Tue May 3 12:03:34 2005","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 62 5e-011","SMU.28","","Residues 1 to 174 (E-value = 1e-42) place SMu0024 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Dec 5 13:11:13 2001","24378556","","Qi,F., Chen,P. and Caufield,P.W.Purification of mutacin III from group III Streptococcus mutansUA787 and genetic analyses of mutacin III biosynthesis genesAppl. Environ. Microbiol. 65 (9), 3880-3887 (1999)PubMed: 10473390 Qi,F., Chen,P. and Caufield,P.W.Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis GenesAppl. Environ. Microbiol. 66 (8), 3221-3229 (2000)PUBMED 10919773Novak,J., Caufield,P.W. and Miller,E.J.Isolation and biochemical characterization of a novel lantibioticmutacin from Streptococcus mutansJ. Bacteriol. 176 (14), 4316-4320 (1994)PubMed: 8021218Qi,F., Chen,P. and Caufield,P.W.Functional analyses of the promoters in the lantibiotic mutacin IIbiosynthetic locus in Streptococcus mutansAppl. Environ. Microbiol. 65 (2), 652-658 (1999)PubMed: 9925596","","Fri Apr 26 08:55:28 2002","","1","","3","SMU.28","" "SMu0025","31867","32574","708","ATGGCAAAAGAACTTATTTATTCGGGTAAAGCTAAGGATATTTTGACGACAGAAGACGAAAATGTGATTATTGCACAATATAAAGACCAAGCGACAGCTCTTAACGGAGTGAAAAAAGAACAAATCGCAGGTAAGGGGCAGCTTAATAATCAGATTTCGTCTTTAATTTTTCAAAAATTAAATGCGGCTGGGGTTGCAACGCATTTTATTAAAAAGATTTCAGAAACAGAACAATTGAATAAAAAAGTTAAGATTATTCCGCTTGAAGTTGTTTTGCGTAATGTGACAGCAGGCTCTTTTTCCAAACGTTTTGGCGTTAAGGAAGGTATTCAGTTGGAGAAGCCAATTGTTGAATTTTACTATAAAAATGATGATTTGGATGATCCTTTTATTAATGATGAACATGTGAAATTTTTAAAGCTTGCTAACGATGAAGATATTGCCTATATTAAAGCTGAAACACGTCGGATAAACAAACTCTTGTCAGATTGGTTCCATCAAATCGGACTTAAATTAATTGATTTTAAATTGGAATTCGGTTTTGATAAAGATGGTAAAATTATCCTAGCAGATGAGTTTTCACCAGATAACTGTCGTCTTTGGGATGCGCAAGGGCATCACATGGACAAAGATGTCTTCCGAAGAGGGTTAGGAGAATTAACGGATGTTTACGAAGTGGTATGGGAAAAATTGCAAGAACTTAAGTAA","6.10","-2.83","26960","MAKELIYSGKAKDILTTEDENVIIAQYKDQATALNGVKKEQIAGKGQLNNQISSLIFQKLNAAGVATHFIKKISETEQLNKKVKIIPLEVVLRNVTAGSFSKRFGVKEGIQLEKPIVEFYYKNDDLDDPFINDEHVKFLKLANDEDIAYIKAETRRINKLLSDWFHQIGLKLIDFKLEFGFDKDGKIILADEFSPDNCRLWDAQGHHMDKDVFRRGLGELTDVYEVVWEKLQELK","32571","For other 'pur' genes see SMu0026 (purL); SMu0028 (purF), (purB);SMu0030 (purM) ; SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0054 (purB); SMu0243 (purA);SMu0321 (purR).","phosphoribosylaminoimidazole-succinocarboxamide synthase","Cytoplasm","Matches in gapped BLAST to SAICAR proteins. For example, residues 1-235 are 85% similar to the enzyme from S.pneumoniae (gi15902089). Residues 1-231 are 77% similar to the enzyme from S.pyogenes (gi15674268).See Spy0024.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0024 (1e-104).","

InterPro
IPR001636
Family

SAICAR synthetase
PD003043	$\"[5-85]T$	SAICAR_synt
PTHR11609	$\"[25-232]T$	SAICAR_synt
PF01259	$\"[2-235]T$	SAICAR_synt
TIGR00081	$\"[1-227]T$	purC
PS01057	$\"[85-99]T$	SAICAR_SYNTHETASE_1
PS01058	$\"[172-180]T$	SAICAR_SYNTHETASE_2

InterPro
IPR013816
Domain

ATP-grasp fold, subdomain 2
G3DSA:3.30.470.20	$\"[84-217]T$	ATP_grasp_subdomain_2

noIPR
unintegrated

unintegrated
G3DSA:3.30.200.20	$\"[5-83]T$	G3DSA:3.30.200.20
PTHR11609:SF3	$\"[25-232]T$	PTHR11609:SF3
SSF56104	$\"[12-234]T$	SSF56104

","BeTs to 12 clades of COG0152COG name: Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthaseFunctional Class: FThe phylogenetic pattern of COG0152 is amtkyqvcebrh--------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001636 (SAICAR synthetase) with a combined E-value of 7.1e-68. IPB001636A 6-19 IPB001636B 28-58 IPB001636C 79-99 IPB001636D 105-129 IPB001636E 169-182 IPB001636F 187-202 IPB001636G 208-217","Residues 3-235 are 85% similar to a (SYNTHASE SYNTHETASE SAICAR) protein domain (PD003043) which is seen in PUR7_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 1 17:16:42 2006","Wed Dec 5 13:23:30 2001","Fri Feb 3 10:22:39 2006","Thu Mar 28 11:01:44 2002","Wed Dec 5 13:23:30 2001","Wed Dec 5 13:23:30 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0025 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 11:01:44 2002","","No significant hits to the NCBI PDB database.","SMU.29","","Residues 2 to 235 (E-value = 9.4e-119) place SMu0025 in the SAICAR_synt family which is described as SAICAR synthetase (PF01259)","Wed Dec 5 13:23:30 2001","24378557","","","Tiedeman,A.A., DeMarini,D.J., Parker,J. and Smith,J.M.DNA sequence of the purC gene encoding5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamidesynthetase and organization of the dapA-purC region of Escherichiacoli K-12Journal of bacteriology. 172 (10), 6035-6041 (1990)PubMed: 2120198Kilstrup,M., Jessing,S.G., Wichmand-Jorgensen,S.B., Madsen,M. andNilsson,D.Activation control of pur gene expression in Lactococcus lactis:proposal for a consensus activator binding sequence based ondeletion analysis and site-directed mutagenesis of purC and purDpromoter regionsJ. Bacteriol. 180 (15), 3900-3906 (1998)PubMed: 9683487Ebbole,D.J. and Zalkin,H.Cloning and characterization of a 12-gene cluster from Bacillussubtilis encoding nine enzymes for de novo purine nucleotidesynthesisJ. Biol. Chem. 262 (17), 8274-8287 (1987)PubMed: 3036807","","Fri Sep 1 17:16:42 2006","1","","3","SMU.29","220" "SMu0026","32584","36309","3726","ATGGATAGACGTATTTTTGTTGAGAAAAAAGCTAACTTTAGCATTAAATCGGAGTCACTGGTCAAAGAACTAACACATAATTTGCAGTTAACCTCCTTAAAAATTTTACGTATTGTGCAGGTTTATGATATCTTTAATTTAGAAGAAAGCCTGTTTGCGCGTGCGCAAAAGCATGTCTTTTCTGAGCAGGTGACAGATACAATTTTAGATGAAGCAACTGTGCAGGCGGATCTTAACAGCCATGCTTTTTTTGCTATTGAAGCTTTGCCGGGTCAGTTTGACCAGCGGGCAGCAAGTTCACAAGAAGCTTTGCTCTTACTTGGTAGTGACAGCAACGTAACGGTTAATACTGCCCAGCTTTATCTGGTTAATAAGGATATTGATGCATCTGAGTTGGAAGCGGTGAAGCATTATCTTTTGAATCCAGTTGATTCGCGTTTCAAAGATATCACCTTGCCTATTCGTCCACAGGAATTTTCAAATTCTGACAAAACAATTCCAAATTTGGATTTCTTTAAGACTTATACAGCTGAAGATTTTGCGGCTTACAAGGCGGAACAAGGTTTGGCTATGGAAGTGGATGATCTTGTTTTTATTCAAGATTATTTTAAATCAATTGGGCGTGTGCCAACAGAAACGGAATTGAAAGTTTTGGATACCTACTGGTCTGACCACTGCCGTCACACGACTTTTGAGACAGAATTGAAAAATATTAACTTTTCAGCTTCTAAGTTCCAAAAACAATTGCAGACAACTTATGATAAATATATTGCCATGCGTGACGAATTGGGACGTTCTGAAAAGCCACAGACGCTTATGGATATGGCGACAATCTTTGGTCGTTATGAGCGTGCTAACGGTCGTTTGAACGACATGGAAGTGTCGGACGAAATCAATGCCTGCTCGGTTGAAATTGAGGTAGATGTAGATGGCATCAAAGAACCTTGGCTGCTCATGTTCAAAAATGAAACCCACAATCACCCAACGGAAATTGAGCCTTTCGGTGGAGCTGCAACTTGTATTGGTGGTGCTATTCGTGACCCATTGTCAGGTCGTTCTTATGTTTACCAAGCTATGCGTATATCAGGTGCAGGTGATATTACCGCACCAATAGCAGAAACACGCTCTGGTAAATTGCCACAACAAGTCATCTCTAAAACGGCGGCGCACGGCTATTCGTCATACGGGAACCAAATAGGACTTGCGACTACCTATGTCAAAGAGTACTTCCATCCAGGCTTCGTTGCTAAGCGTATGGAGCTAGGTGCTGTTGTCGGTGCAGCACCAAAAGAAAATGTCGTGCGTGAAAAACCAGAAGCTGGTGATGTGGTCATCCTTCTTGGTGGAAAAACAGGACGTGACGGTGTCGGTGGTGCTACAGGCTCATCTAAGGTTCAAACGGTTGAATCGGTTGAGACAGCAGGTGCCGAAGTGCAAAAAGGGAATGCTATTGAAGAACGTAAGATTCAACGTCTTTTCCGCAATGGCAATGTCACTCGTCTCATCAAGAAATCAAATGATTTTGGTGCTGGCGGCGTCTGTGTGGCTATTGGTGAATTGGCAGATGGTCTTGAAATTGACTTGGACAAAGTGCCACTAAAATACCAAGGTCTTAACGGTACCGAAATTGCCATTTCTGAGTCACAAGAACGCATGGCTGTTGTTGTTCGTCCAAGTGATGTGGACGCCTTTATTGCAGCATGTCATAAAGAGAACATTGATGCAGTTGTTGTCGCGACTGTTACTGAAAAACCAAACCTTGTCATGACTTGGAATGGTGAAACCATCGTTGACTTGGAACGTGCCTTCCTTGATACTAACGGTGTGCGTGTGGTTGTTGATGCAAACGTTGTGGATAAGGATGTTGCCCTTCCTGAGGTGCGTACAACATCAGCAGCAACACTTGAAGCAGACACAGTGAAAGTTCTGTCTGATCTTAACCACGCTAGTCAAAAAGGGTTGCAAACTATCTTTGACAGCTCGGTTGGGCGTTCAACAGTTAATCATCCAATCGGCGGTCGTTATCAAATTACGCCTACTGAAGCTTCTGTGCAAAAATTGCCAGTACAAAATGGTGTCACAACGACAGCTTCTGTCATGGCACAGGGATTCAATCCTTATATTGCGGAGTGGTCACCTTATCATGGTGCAGCTTACGCTGTTATTGAAGCAACAGCTCGCTTGGTAGCAACAGGTGCTGATTGGTCTCGTGCGCGTTTCTCTTACCAAGAATACTTTGAACGCATGGATAAACAAGCGGATCGCTTTGGTCAGCCAGTAGCTGCTCTGCTTGGTTCGATCGAGGCACAAATCCAACTTGGTTTGCCATCAATCGGTGGTAAGGACTCCATGTCAGGGACCTTTGAAGAATTGACGGTACCGCCAACCTTGGTTGCCTTTGGTGTGACAACAGTAGATAGTCGTCAGGTTCTTTCACCAGAATTCAAGACTGTTGGTGAGAACATTTACTACATCCCAGGACAGGCTATTTCAGAAGACATTAATTTTGATTATATCAAGGCTAACTTTGCACAATTTGAAGCCATTCAAGCTAAACATAAAGTAACAGCAGCTTCAGCTATTAAATACGGCGGTGTTCTTGAAAGCCTAGCACTCATGAGCTTTGGTAATCATATTGGTGCTTCTGTAGAATTGACAGAGCTTGACAGCAGCTTGACAGCGCAGCTTGGTGGTTTTGTCTTTACATCTGATGAAGCCATTGCTGACGCAGTGAAAATTGGTCAAACTGTGGCAGACTTTACAGTAACTGTCAACGGTGTCAACTTGTCCGCTGCGAAATTACTTGCAGCTTTTGAGGGCAGGTTAGAGGAGGTTTACCCAACCGAATTTGAACAGTCAACAGCTCTTGAAGAAATACCTGCTGTGGTATCTGATGCTGTTATTAAAGCTAAAGAAAGAATTGCACAGCCTCTGGTTTATATCCCAGTTTTCCCTGGTTCCAATTCAGAGTACGATTCAGCTAAGGCCTTTGAACAAGCTGGTGCCAAAGTCAACTCAGTGCCATTTGTGACTCTTAATGAAGCAGCGATTGAGGCTTCTGTTGACACCATGGTTGACAACATTGTTAAAGCCAATATTATCTTCTTTGTCGGCGGCTTCTCAGCGGCAGATGAGCCAGACGGTTCGGCTAAGTTTATCGTCAATATCTTACTTAATGAAAAAGTTTGCTCTGCTATTGACAGCTTCATTGAAAGGGGTGGCCTCATCATCGGTATCTGTAATGGGTTTCAAGCTCTTGTCAAATCCGGTCTTCTGCCTTATGGTGACTTTGAAGAAGTTGGTGAGACAAGCCCAACCCTCTTCTACAATGATGCCAATCAGCACGTGGCTAAGATGGTAGAAACCCGTATCACTAATACTAACTCTCCATGGTTGGCAGGTGTTAAGATCGGTGATATCCATGCGATTCCAGTCTCTCACGGTGAAGGGAAATTTGTCGTGACAGCTGAAGAATTTGCGGAACTGCGTGACAATGGTCAAATCTGGAGCCAATACGTGGACTTTGATGGTAAGCCTTCTATGGATTCTAAATACAATCCAAACGGTTCGCTCAACGCTATTGAAGGGATTACGAGCAAGAACGGTCAAATCATTGGTAAGATGGGACACTCGGAACGCTATGAAAACGGGCTCTTTCAAAACATCCCAGGTAACAAAGATCAAGGCCTATTTGAAAGTGCAGTGAAATACTTTACTGGGAAATAG","4.70","-49.34","135158","MDRRIFVEKKANFSIKSESLVKELTHNLQLTSLKILRIVQVYDIFNLEESLFARAQKHVFSEQVTDTILDEATVQADLNSHAFFAIEALPGQFDQRAASSQEALLLLGSDSNVTVNTAQLYLVNKDIDASELEAVKHYLLNPVDSRFKDITLPIRPQEFSNSDKTIPNLDFFKTYTAEDFAAYKAEQGLAMEVDDLVFIQDYFKSIGRVPTETELKVLDTYWSDHCRHTTFETELKNINFSASKFQKQLQTTYDKYIAMRDELGRSEKPQTLMDMATIFGRYERANGRLNDMEVSDEINACSVEIEVDVDGIKEPWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPIAETRSGKLPQQVISKTAAHGYSSYGNQIGLATTYVKEYFHPGFVAKRMELGAVVGAAPKENVVREKPEAGDVVILLGGKTGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDFGAGGVCVAIGELADGLEIDLDKVPLKYQGLNGTEIAISESQERMAVVVRPSDVDAFIAACHKENIDAVVVATVTEKPNLVMTWNGETIVDLERAFLDTNGVRVVVDANVVDKDVALPEVRTTSAATLEADTVKVLSDLNHASQKGLQTIFDSSVGRSTVNHPIGGRYQITPTEASVQKLPVQNGVTTTASVMAQGFNPYIAEWSPYHGAAYAVIEATARLVATGADWSRARFSYQEYFERMDKQADRFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLVAFGVTTVDSRQVLSPEFKTVGENIYYIPGQAISEDINFDYIKANFAQFEAIQAKHKVTAASAIKYGGVLESLALMSFGNHIGASVELTELDSSLTAQLGGFVFTSDEAIADAVKIGQTVADFTVTVNGVNLSAAKLLAAFEGRLEEVYPTEFEQSTALEEIPAVVSDAVIKAKERIAQPLVYIPVFPGSNSEYDSAKAFEQAGAKVNSVPFVTLNEAAIEASVDTMVDNIVKANIIFFVGGFSAADEPDGSAKFIVNILLNEKVCSAIDSFIERGGLIIGICNGFQALVKSGLLPYGDFEEVGETSPTLFYNDANQHVAKMVETRITNTNSPWLAGVKIGDIHAIPVSHGEGKFVVTAEEFAELRDNGQIWSQYVDFDGKPSMDSKYNPNGSLNAIEGITSKNGQIIGKMGHSERYENGLFQNIPGNKDQGLFESAVKYFTGK","36306","For other 'pur' genes see SMu0025 (pur7); SMu0028 (purF), (purB);SMu0030 (purM) ; SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0054 (purB); SMu0243 (purA);SMu0321 (purR).Note tandem repeats at 35236,35264.","phosphoribosylformylglycinamidine synthase","Cytoplasm","Matches in gapped BLAST to FGAM proteins. Residues 1-1241 are 89% similar to the enzyme from S.pyogenes (gi15674269) and 86% similar to the enzyme from S.pneumoniae (gi15902090).See Spy0025.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0025 (0.0).","

InterPro
IPR000728
Domain

AIR synthase related protein
PF00586	$\"[312-347]T$	AIRS

InterPro
IPR010141
Family

Phosphoribosylformylglycinamidine synthase, FGAM
TIGR01857	$\"[3-1238]T$	FGAM-synthase

InterPro
IPR010918
Domain

AIR synthase related protein, C-terminal
PF02769	$\"[439-592]T$	AIRS_C

noIPR
unintegrated

unintegrated
PTHR10099	$\"[475-1239]T$	PTHR10099
SSF109736	$\"[162-229]T$	SSF109736
SSF52317	$\"[970-1239]T$	SSF52317
SSF55326	$\"[217-436]T$ $\"[619-812]T$	SSF55326
SSF56042	$\"[438-615]T$ $\"[813-971]T$	SSF56042

","BeTs to 11 clades of COG0046COG name: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domainFunctional Class: FThe phylogenetic pattern of COG0046 is amtkyqvcebrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1099-1213 are 34% similar to a (SYNTHASE) protein domain (PD004290) which is seen in O67190_AQUAE.Residues 307-410 are 34% similar to a (SYNTHASE II) protein domain (PD004591) which is seen in Q9HJA4_THEAC.Residues 440-599 are 37% similar to a (SYNTHASE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE) protein domain (PD001440) which is seen in PURL_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 3 10:30:19 2006","Wed Dec 5 13:38:18 2001","Fri Feb 3 10:30:19 2006","Thu Mar 28 11:02:53 2002","","Wed Dec 5 13:38:18 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0026 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 11:02:53 2002","","No significant hits to the NCBI PDB database.","SMU.30","","Residues 439 to 592 (E-value = 8e-35) place SMu0026 in the AIRS_C family which is described as AIR synthase related protein, C-terminal domain (PF02769)","Wed Dec 5 13:38:18 2001","24378558","","","Peltonen,T. and Mantsala,P.Isolation and characterization of a purC(orf)QLF operon fromLactococcus [correction of Lactobacillus] lactis MG1614Mol. Gen. Genet. 261 (1), 31-41 (1999)PubMed: 10071207Ebbole,D.J. and Zalkin,H.Cloning and characterization of a 12-gene cluster from Bacillussubtilis encoding nine enzymes for de novo purine nucleotidesynthesisJ. Biol. Chem. 262 (17), 8274-8287 (1987)PubMed: 3036807","","Thu Mar 28 11:02:53 2002","1","","3","SMU.30","5" "SMu0027","36331","36951","621","ATGAAACAGTATGTTGCAAGGCTAGAAAAAGATTTTTCACTCATAGAACACGGATTTAAAGAGGAAGAACAAAGAGCCTTAACTGATTATAAATCCAATGATGGTGAGTATATCAAGAAATTAGCATTTTTAGCTTATCAATCTGATGTTTACCAAGTAAGAATGTACGCTGTATTCCTTTTCGGATACTTATCAAAAGATAAAGAAATTTTAATATTCATGAGAGATGAAGTTTCTAAAGATAATAACTGGAGAGTTCAAGAAGTGTTAGCAAAGGCGTTTGATGAATTTTGTAAGAAAATAGAATATAAAAAAGCACTTCCAATTATTGATGAATGGTTAAAAAGTAGCAATCTCCATACGAGGAGAGCTGCTACAGAAGGGTTAAGAATATGGACAAATAGACCATACTTTAAAGAGAACCCTAATGAAGCTATCAGAAGAATAGCTGACTTAAAAGAGGATGTAAGCGAATATGTTAGAAAATCAGTAGGGAATGCTTTAAGAGACATTAGCAAAAAATTTCCAGATTTAGTTAAAATTGAGTTGAAAAATTGGAAATTAGAAAGTAAAGAAATTAACCAAGTTTATAAATTGGCAAGTAAATTTATTGATGCCTAG","9.80","5.45","24512","MKQYVARLEKDFSLIEHGFKEEEQRALTDYKSNDGEYIKKLAFLAYQSDVYQVRMYAVFLFGYLSKDKEILIFMRDEVSKDNNWRVQEVLAKAFDEFCKKIEYKKALPIIDEWLKSSNLHTRRAATEGLRIWTNRPYFKENPNEAIRRIADLKEDVSEYVRKSVGNALRDISKKFPDLVKIELKNWKLESKEINQVYKLASKFIDA","36948","","conserved hypothetical protein","Cytoplasm","Residues 17-204 are 48% similar to gi22961456, an hypotheticalprotein from Rhodopseudomonas palustris, a bacterium. Residues 101-186 are 35% similar to residues 125-214 of yhaZ in B.subtilis (gi16078046).No significant similarity in Spy.SMu0027 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF48371	$\"[46-171]T$	SSF48371

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 101-186 are 35% similar to a (PROTEOME COMPLETE PM1750 ENZYME) protein domain (PD359682) which is seen in O07541_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 17:16:39 2002","Mon Oct 28 17:16:39 2002","Fri Feb 3 10:37:05 2006","Wed Dec 5 13:55:22 2001","","Wed Dec 5 13:55:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0027 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 14:51:22 2002","","No significant hits to the NCBI PDB database.","SMU.31","","No significant hits to the Pfam 11.0 database","Wed Dec 5 13:55:22 2001","24378559","","","","","","1","","3","SMU.31","" "SMu0028","36977","38416","1440","ATGACATACGAAGTAAAATCTCTCAACGAAGAATGTGGGGTCTTCGGTATCTGGGGACATCCTCAAGCAGCTCAAGTCACTTATTTTGGACTGCATAGTCTGCAACACCGTGGTCAAGAAGGTGCTGGCATTCTGACAAATGATGCTGGCAAATTGATACGACATCGTGATACAGGATTAATTTCAGAAGTTTTCAAAAATCCAGCTAATTTGGAAAAATTAACAGGTCAGGCTGCTATTGGGCATGTCCGTTATGCAACGGCTGGAGAAGCCTCCATTGATAATATCCAGCCTTTCCATTTTAAGTTTTACGATATGGAATTTGGTCTGGCACATAACGGTAACCTGACTAATACGAAAACCCTGAAGAAAGAATTAGAACATAACGGCGCTATCTTCTCTTCTTCATCTGATACGGAAATTCTGGCTCATCTTATTCGCCGCAGCCATAATCCAAGCTTTATGGGTAAGGTTAAGGAAGCGCTCAATACGGTCAAAGGTGGTTTTGCCTATCTTCTGATGATGGAAGATAAGCTGATTGCAGCTCTTGATCCAAACGGTTTTCGTCCGCTTTCTATTGGTAAAATGGCAAATGGTGCCATCGTTGTTTCCAGCGAAACCTGTGCCTTTGAAGTGGTGGGTGCCGAGTGGATTCGTGATGTCAAGCCGGGTGAAGTGGTTATCATTGATAATAGTGGTATCCAGTACGACACTTACACGACAGATACGCAGTTGGCTATTTGTTCAATGGAATACATCTACTTTGCCCGTCCTGACTCAAATATTCACGGGGTCAATGTCCACACTGCTCGTAAACGTATGGGAGCACAGTTGGCGCGTGAGTTCAAACATGAGGCAGACATTGTGGTCGGTGTACCTAATTCCTCACTCAGCGCAGCTATGGGCTTCGCCGAAGAATCAGGACTGCCAAATGAAATGGGTCTTATCAAAAATCAATACACCCAACGAACCTTTATCCAGCCAACGCAGGAACTGCGTGAGCAAGGGGTTCGCATGAAACTTTCTGCCGTATCTGGAGTGGTTAAAGGCAAACGTGTCGTCATGATTGATGACTCCATCGTGCGTGGGACAACCTCACGTCGTATCGTTCAGCTCTTGAAAGAAGCTGGTGCTACAGAGGTTCACGTGGCTATCGGTAGCCCAGCGCTGGCCTATCCATGTTTCTATGGGATTGATATTCAAACACGGCGTGAATTGATTGCGGCTAATCATTCTGTTGAAGAAACACGCCAGATTATCGGTGCGGATAGCCTAACTTACTTGTCTATTGACGGTTTGATTGACTCTATCGGACTTGAAACAGATGCCCCAAACGGCGGTCTCTGTGTTGCTTACTTTGATGGCAAGTACCCAACACCGCTTTACGATTACGAAGAAGAGTATCGTAGAAGCTTGGATGAGAAGGTTAGCTTTTATTGA","6.10","-7.59","52745","MTYEVKSLNEECGVFGIWGHPQAAQVTYFGLHSLQHRGQEGAGILTNDAGKLIRHRDTGLISEVFKNPANLEKLTGQAAIGHVRYATAGEASIDNIQPFHFKFYDMEFGLAHNGNLTNTKTLKKELEHNGAIFSSSSDTEILAHLIRRSHNPSFMGKVKEALNTVKGGFAYLLMMEDKLIAALDPNGFRPLSIGKMANGAIVVSSETCAFEVVGAEWIRDVKPGEVVIIDNSGIQYDTYTTDTQLAICSMEYIYFARPDSNIHGVNVHTARKRMGAQLAREFKHEADIVVGVPNSSLSAAMGFAEESGLPNEMGLIKNQYTQRTFIQPTQELREQGVRMKLSAVSGVVKGKRVVMIDDSIVRGTTSRRIVQLLKEAGATEVHVAIGSPALAYPCFYGIDIQTRRELIAANHSVEETRQIIGADSLTYLSIDGLIDSIGLETDAPNGGLCVAYFDGKYPTPLYDYEEEYRRSLDEKVSFY","38413","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0030 (purM) ; SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0054 (purB); SMu0243 (purA); SMu0321 (purR). ","amidophosphoribosyltransferase","Cytoplasm","Matches in gapped BLAST to phosphoribosylpyrophosphate amidotransferase sequences. Residues 1-479 are 89% similar to the enzyme from S.pneumoniae (gi15899991) and are 83% similar to the enzyme from S.pyogenes (gi15674270).See Spy0026.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0026 (0.0).","

InterPro
IPR000583
Domain

Glutamine amidotransferase, class-II
PF00310	$\"[12-207]T$	GATase_2
PS00443	$\"[1-16]?$	GATASE_TYPE_II

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[256-401]T$	Pribosyltran

InterPro
IPR002375
Family

Purine/pyrimidine phosphoribosyl transferase
PS00103	$\"[353-365]T$	PUR_PYR_PR_TRANSFER

InterPro
IPR005854
Family

Amidophosphoribosyl transferase
PTHR11907	$\"[1-473]T$	Amd_phspho_trans
TIGR01134	$\"[12-458]T$	purF

noIPR
unintegrated

unintegrated
G3DSA:3.60.20.10	$\"[12-317]T$	G3DSA:3.60.20.10
SSF53271	$\"[247-463]T$	SSF53271
SSF56235	$\"[12-266]T$	SSF56235

","BeTs to 11 clades of COG0034COG name: Glutamine phosphoribosylpyrophosphate amidotransferaseFunctional Class: FThe phylogenetic pattern of COG0034 is amtkyqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000583 (Glutamine amidotransferase class-II) with a combined E-value of 1.1e-26. IPB000583A 34-44 IPB000583B 80-89 IPB000583C 112-140 IPB000583D 322-337***** IPB002375 (Purine/pyrimidine phosphoribosyl transferase) with a combined E-value of 1.9e-06. IPB002375B 350-365","Residues 74-234 are 73% similar to a (AMIDOTRANSFERASE ASPARAGINE AMINOTRANSFERASE GLUTAMINE) protein domain (PD000635) which is seen in Q9ZB05_BBBBB.Residues 179-229 are 47% similar to a (GLUTAMINE AMIDOTRANSFERASE) protein domain (PD302190) which is seen in PUR1_ARCFU.Residues 248-457 are 76% similar to a (AMIDOTRANSFERASE GLUTAMINE) protein domain (PD002836) which is seen in Q9ZB05_BBBBB.Residues 12-61 are 74% similar to a (AMIDOTRANSFERASE AMINOTRANSFERASE GLUTAMINE) protein domain (PD001242) which is seen in Q9ZB05_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Jul 9 09:01:14 2006","Sun Jul 9 09:01:14 2006","Fri Feb 3 10:39:42 2006","Thu Mar 28 11:03:49 2002","Wed Dec 5 13:56:38 2001","Wed Dec 5 13:56:38 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0028 is weakly paralogous to SMu1086, a predicted glucosamine-fructose-6-phosphate aminotransferase. Residues 12-239 are 26% similar to residues 2-225 of SMu1086.SMu0028 is paralogously related (blast p-value < 1e-3) to SMu1086, and SMu0330.","Thu Mar 28 11:03:49 2002","Fri Feb 3 10:39:42 2006","pdb1AO0A Chain A, Glutamine Phosphoribosylpyrophosphate (Prpp... 566 2e-162pdb1GPH1 Chain 1, Glutamine Phosphoribosylpyrophosphate (Prpp... 565 3e-162pdb1ECFB Chain B, Escherichia Coli Glutamine Phosphoribosylpy... 301 1e-082","SMU.32","","Residues 12 to 148 (E-value = 1.4e-49) place SMu0028 in the GATase_2 family which is described as Glutamine amidotransferases class-II (PF00310)Residues 256 to 401 (E-value = 5.7e-09) place SMu0028 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Fri Feb 3 10:39:42 2006","24378560","","","","","","1","","3","SMU.32","6" "SMu0029","38633","38914","282","ATGGCTGCATTAGCTAGTTTTGGTTTTGGTGGAGCAGTTGGAGGAATTGCAACTTTGACAGTTTCTGTAGCAGTCCCCGTGGTTCTAGTAGCTGGTAGCTTTTATACAGTAGCTAATCAAAGAAAATTAAAACAAGAATTAATCAAATTGTTTAGATTTGTAAAAAATCTAGAACCTAAACTTGTTGATGATGAGAGATCTAAGGTGCAGGAATTATTAAAGAGTATTGATTTAACAATGGTTGAATTGAAAAAACGATACAAAATTTCCAAGGTAAAATAG","10.80","7.98","10223","MAALASFGFGGAVGGIATLTVSVAVPVVLVAGSFYTVANQRKLKQELIKLFRFVKNLEPKLVDDERSKVQELLKSIDLTMVELKKRYKISKVK","38911","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu0029 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-24]?$	signal-peptide
tmhmm	$\"[14-34]?$	transmembrane_regions

InterPro
IPR000728
Domain

AIR synthase related protein
PF00586	$\"[3-164]T$	AIRS

InterPro
IPR004733
Domain

Phosphoribosylformylglycinamidine cyclo-ligase
TIGR00878	$\"[5-332]T$	purM

InterPro
IPR010918
Domain

AIR synthase related protein, C-terminal
PF02769	$\"[175-340]T$	AIRS_C

noIPR
unintegrated

unintegrated
G3DSA:3.30.1330.10	$\"[7-169]T$	G3DSA:3.30.1330.10
G3DSA:3.90.650.10	$\"[170-334]T$	G3DSA:3.90.650.10
PTHR10520	$\"[2-340]T$	PTHR10520
SSF55326	$\"[3-169]T$	SSF55326
SSF56042	$\"[170-339]T$	SSF56042

","BeTs to 11 clades of COG0150COG name: Phosphoribosylaminoimidazol (AIR) synthetase PurMFunctional Class: FThe phylogenetic pattern of COG0150 is amtkyqvcebrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 140-199 are 93% similar to a (SYNTHETASE LIGASE CYCLO-LIGASE) protein domain (PD000644) which is seen in Q9F1T6_STRSU.Residues 221-323 are 36% similar to a (PROTEOME COMPLETE CYCLO-LIGASE) protein domain (PD293578) which is seen in Q9X0X8_THEMA.Residues 87-125 are 74% similar to a (SYNTHETASE LIGASE PURINE CYCLO-LIGASE) protein domain (PD398914) which is seen in Q55422_SYNY3.Residues 7-86 are 71% similar to a (SYNTHETASE LIGASE) protein domain (PD096289) which is seen in O68186_LACLC.Residues 219-313 are 85% similar to a (SYNTHETASE LIGASE CYCLO-LIGASE PURINE) protein domain (PD002449) which is seen in Q9F1T6_STRSU.Residues 82-139 are 98% similar to a (KINASE COMPLETE PROTEOME HYDROGENASE THIAMINE) protein domain (PD344351) which is seen in Q9F1T6_STRSU.Residues 4-108 are 32% similar to a (PROTEOME COMPLETE CYCLO-LIGASE) protein domain (PD244461) which is seen in Q9X0X8_THEMA.Residues 6-85 are 37% similar to a (SYNTHETASE GLYCINAMIDE BIOSYNTHETIC) protein domain (PD407182) which is seen in PUR2_DROPS.Residues 5-85 are 34% similar to a (PROTEOME COMPLETE CYCLO-LIGASE) protein domain (PD260518) which is seen in Q9RUJ2_DEIRA.Residues 20-81 are 67% similar to a (SYNTHETASE LIGASE) protein domain (PD405636) which is seen in Q9F1T6_STRSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 3 10:42:54 2006","Wed Dec 5 14:39:51 2001","Fri Feb 3 10:42:54 2006","Thu Mar 28 11:07:05 2002","","Wed Dec 5 14:13:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0030 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 11:07:05 2002","Fri Feb 3 10:42:54 2006","pdb1CLIA Chain A, X-Ray Crystal Structure Of Aminoimidazole R... 306 2e-084","SMU.34","","Residues 3 to 164 (E-value = 1.8e-67) place SMu0030 in the AIRS family which is described as AIR synthase related protein, N-terminal domain (PF00586)Residues 175 to 340 (E-value = 2.2e-47) place SMu0030 in the AIRS_C family which is described as AIR synthase related protein, C-terminal domain (PF02769)","Fri Feb 3 10:42:54 2006","24378562","","","Li C, Kappock TJ, Stubbe J, Weaver TM, Ealick SE.X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution.Structure Fold Des. 1999 Sep 15;7(9):1155-66.PMID: 10508786 Ebbole DJ, Zalkin H.Bacillus subtilis pur operon expression and regulation.J Bacteriol. 1989 Apr;171(4):2136-41.PMID: 2495272 ","","Wed Dec 5 14:23:16 2001","1","","3","SMU.34","221" "SMu0031","39982","40536","555","ATGGCTCAAAAAATTGCTGTTTTCGCTTCTGGTAATGGGTCAAATTTTCAGGTCATCGGCGAGCAATTCCCAGTAGAATTTGTTTTCTCTGACCATCGTGATGCCTATGTCTTGGAGCGTGCTAAAAATCTCGGTATCAAAAGTTACGCCTTTGAACTCAAGGAATTTGACAACAAAATTGCTTATGAGCAGGCTATCATTGACCTCTTGGAAAAATATGCTATTGATCTTGTTTGCCTAGCTGGTTACATGAAAATCGTTGGCCCAACCTTGCTGGCTGCCTATCAAGGTCGCATTATCAATATCCATCCAGCCTATTTGCCAGAATTTCCAGGTGCTCATGGTATCGAAGATGCCTGGAATGCCGGTGTCACTGAGAGCGGAGTGACCATTCACTGGGTGGACTCAGGTGTGGATACTGGCAAGGTCATTAAACAAGTCCGTGTCCCACGGCTAGTTCATGACACGATTGAAAGTTTTGAAGAACGCATTCATGCTGCTGAGTATCAGCTCTATCCTCAAGTGCTGGAGAGTTTAGGGATCGAGAGAAGATAA","5.20","-6.60","20625","MAQKIAVFASGNGSNFQVIGEQFPVEFVFSDHRDAYVLERAKNLGIKSYAFELKEFDNKIAYEQAIIDLLEKYAIDLVCLAGYMKIVGPTLLAAYQGRIINIHPAYLPEFPGAHGIEDAWNAGVTESGVTIHWVDSGVDTGKVIKQVRVPRLVHDTIESFEERIHAAEYQLYPQVLESLGIERR","40533","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0028(purF),(purB) ; SMu0030 (purM); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0054 (purB); SMu0243 (purA); SMu0321 (purR). ","phosphoribosylglycinamide formyltransferase","Cytoplasm","Numerous matches in gapped BLAST to Phosphoribosylglycinamide formyltransferase sequences. Residues 4-184 are 82% similar to the enzyme in S.pyogenes (gi|15674272). Residues 3-179 are 80% similar to the enzyme in S.pneumoniae (gi|15899993).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0028 (4e-84).","

InterPro
IPR002376
Domain

Formyl transferase, N-terminal
G3DSA:3.40.50.170	$\"[3-177]T$	Formyl_transf_N
PF00551	$\"[3-176]T$	Formyl_trans_N
SSF53328	$\"[3-179]T$	formyl_transf

InterPro
IPR004607
Family

Phosphoribosylglycinamide formyltransferase
PIRSF000413	$\"[2-182]T$	GAR_TFase
TIGR00639	$\"[3-182]T$	PurN

noIPR
unintegrated

unintegrated
PTHR10520	$\"[77-183]T$	PTHR10520
PTHR10520:SF9	$\"[77-183]T$	PTHR10520:SF9

","BeTs to 7 clades of COG0299COG name: Folate-dependent phosphoribosylglycinamide formyltransferase PurNFunctional Class: FThe phylogenetic pattern of COG0299 is ----yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-179 are 78% similar to a (TRANSFERASE FORMYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD001209) which is seen in Q9F1T5_STRSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 17:12:00 2002","Wed Dec 5 14:38:32 2001","Thu Oct 24 17:12:00 2002","Thu Mar 28 13:25:30 2002","","Wed Dec 5 14:38:32 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0031 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 13:25:30 2002","Wed Dec 5 14:38:32 2001","pdb|3GAR| A Ph-Dependent Stablization Of An Active Site Loop... 134 1e-032pdb|1C3E|A Chain A, New Insights Into Inhibitor Design From The... 132 4e-032pdb|1CDD|A Chain A, Phosphoribosylglycinamide Formyltransferase... 132 4e-032","SMU.35","","Residues 3 to 176 (E-value = 9.6e-57) place SMu0031 in the Formyl_trans_N family which is described as Formyl transferase (PF00551)","Wed Dec 5 14:38:32 2001","24378563","","","Saxild HH, Jacobsen JH, Nygaard P.Genetic and physiological characterization of a formate-dependent 5'-phosphoribosyl-1-glycinamide transformylase activity in Bacillus subtilis.Mol Gen Genet. 1994 Feb;242(4):415-20.PMID: 8121396","","Thu Oct 24 17:12:00 2002","1","","3","SMU.35","507" "SMu0032","40643","41350","708","ATGGGTCTATTTGATTTTTTTAAGAAGAAATCTTCCAGTGAAAAGACACCAATTGAAGATGGAGATAAGACTGTTGTTAAATCTGAAGATACAGATGATAGCGCTCCAGGATGGGAAGCGATTGATGCAGAATTTGATCGTTTATATCCTGATCAGCCCAATCCTCTTCATTATGGGACGATTGTCAAGTATATGTTTGGGGGTCCAGATCCGCTTGACGGTATAAGTGTCTACGATGCGGGAGATTTTTGGCATTTTGTCAGCTATGGCTTGTCGGAGTTATATACAAAAGAAAGCACCGACTCAGAATACAGTGGTTATGGGATTGAATTGACTTTTAAGTTAAAGAAATCTACTAATGACGAAGAAGAAATCAAAAATGGCTGTGGTTTATTGCAGTATGTTGCAAGATATATTTTTAAAACAGGAAAAGTAGTTTTACCAGAAGAATATATTTATATGAAGCAAACGGTAGGAATCGATATTCAGCAGAAATCTAAACTGACAGGTTTTCTGACCGTTAGTGACAATCTAGCTAAGCCTCTAGATACTCCTCATGGAAAAGTAGAATTTGTCACTCTGATTGGTGCGACAGATGCAGAACTGCGAAGTGTTTATGAAAGTGAAACAAGTAAGCTTGAGGTAAGGAAATTGTTGCAAGAGCTTGGAAATCAGATTACAGACTATAATCGCCAGTCTTTAGTTTAG","4.50","-13.31","26498","MGLFDFFKKKSSSEKTPIEDGDKTVVKSEDTDDSAPGWEAIDAEFDRLYPDQPNPLHYGTIVKYMFGGPDPLDGISVYDAGDFWHFVSYGLSELYTKESTDSEYSGYGIELTFKLKKSTNDEEEIKNGCGLLQYVARYIFKTGKVVLPEEYIYMKQTVGIDIQQKSKLTGFLTVSDNLAKPLDTPHGKVEFVTLIGATDAELRSVYESETSKLEVRKLLQELGNQITDYNRQSLV","41347","","conserved hypothetical protein (eukaryotic-like)","Cytoplasm","Residues 31-208 are 42% similar to residues 11-188 of gi|23135287, an hypothetical protein from Cytophaga hutchinsonii, a bacterium. Other significant matches are to H.sapiens.SMu0032 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007768
Family

Suppressor of fused
PTHR10928	$\"[36-204]T$	SUFU
PF05076	$\"[27-202]T$	SUFU

noIPR
unintegrated

unintegrated
SSF103359	$\"[31-235]T$	SSF103359

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 36-70 are 65% similar to a (SUPPRESSOR FUSED OF FULL-LENGTH) protein domain (PD398592) which is seen in Q9NZ07_HUMAN.Residues 36-79 are 52% similar to a (SUPPRESSOR SUFU FUSED OF) protein domain (PD413336) which is seen in Q9VG38_DROME.Residues 105-207 are 51% similar to a (SUPPRESSOR FUSED OF FULL-LENGTH) protein domain (PD042957) which is seen in O02493_DROVI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 8 16:39:31 2002","Tue Oct 8 16:15:40 2002","Mon Oct 28 17:18:37 2002","Wed Dec 5 14:54:45 2001","","Wed Dec 5 14:54:45 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0032 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Apr 8 16:38:40 2002","","No significant hits to the NCBI PDB database.","SMU.36","","No significant hits to the Pfam 11.0 database","Wed Dec 5 14:54:45 2001","24378564","","","","","","1","","3","SMU.36","" "SMu0033","41377","42939","1563","ATGAAAGGAAAAAACATGACTAAACGCGCACTTATCAGCGTCTCAGACAAATCGGGTATTGTTGACTTTGCTCAAGAATTGAAAAACTTGGGTTGGGAAATCGTCTCAACCGGCGGAACTAAGGTTGCCCTTGACAAGGCAGGGATTGACACCATCGCTATTGACGATGTGACTGGCTTTCCTGAAATGATGGATGGTCGTGTCAAGACTCTTCACCCAAACATTCATGGCGGTCTATTGGCGCGCCGCGACCTTGATAGTCATGTTAATGCTATGAAGGAACATGAAATCACACCGATTGATTTGGTCGTTGTCAACCTTTACCCATTCAAGGAGACTATTCTTAAACCAGATGCGACCTATGCGGATGCGGTTGAAAATATTGATATCGGTGGACCATCTATGCTGCGCTCAGCAGCTAAAAACCATGCCAGTGTGACGGTTGTGGTTGACCCTGCTGACTACGCTGAGATTCTTGACGAATTGTCAGCTAATGGTGAAACAAGTTTTGAAACTCGTAAGCGTCTGGCAGCAAAAGTTTTCCGTCACACCGCAGCTTACGATGCCCTCATCGCTGAATATTTCACTGCTCAAGTGGGTGAAGAAAAACCTGAAAAACTCACCTTGACTTATGACCTCAAGCAGCCAATGCGTTATGGTGAAAATCCACAGCAGAATGCGGATTTCTACCAAAAAGCCTTGCCAACTGCTTATTCTATTGCCTCTGCTCAGCAGCTCAACGGTAAGGAATTGTCCTTCAACAATATTCGCGATGCTGATGCGGCTATACGTGTCATTCGTGACTTTAAAGACCGTCCAACCGTTGTGGCGCTCAAGCACATGAATCCATGTGGTATCGGTCAGGCTGATGACATTGAAACAGCTTGGGATTACGCTTATGAGGCTGATTTAGTTTCGATCTTCGGCGGCATTGTTGTCCTAAACCGTGAGGTTGATGCAGCGACAGCTGAGAAGATGCACGCTATCTTCCTAGAAATCATCATTGCGCCATCTTATACAGACGAAGCGCTAGCTATTCTCACAACCAAAAAGAAAAATCTGCGTATTCTGCAACTTCCCTTTGACGCTCAAGAAGCTAGCGAGGCTGAAAAAGAGTATACTGGCGTGGTTGGTGGCCTCCTTGTGCAAAATCAAGACGTGGTCAAGGAAAGTCCAGCCGATTGGCAGGTCGTTACCAAGCGCCAGCCAACTAAAACGGAAGAAACTGCTCTTGAATTTGCTTGGAAAGCTATCAAGTATGTCAAGTCTAATGGCATTATCGTGACCAATGACCACATGACACTTGGTGTCGGTCCGGGTCAGACCAATCGTGTCGCTTCTGTTCGCATCGCCATTGACCAAGCTAAAGATCGCCTTGACGGGGCTGTTCTTGCCTCTGATGCTTTCTTCCCGTTTGCTGATAACGTTGAAGAAATTGCAGCTGCTGGTATCAAAGCTATCATCCAACCCGGCGGTTCCGTCCGTGACCAAGAGTCTATCGATATGGCTGATAAATACGGCATTGCTATGGTATTTACGGGTGTGAGACATTTTAGACATTGA","5.10","-15.35","57016","MKGKNMTKRALISVSDKSGIVDFAQELKNLGWEIVSTGGTKVALDKAGIDTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHVNAMKEHEITPIDLVVVNLYPFKETILKPDATYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAEILDELSANGETSFETRKRLAAKVFRHTAAYDALIAEYFTAQVGEEKPEKLTLTYDLKQPMRYGENPQQNADFYQKALPTAYSIASAQQLNGKELSFNNIRDADAAIRVIRDFKDRPTVVALKHMNPCGIGQADDIETAWDYAYEADLVSIFGGIVVLNREVDAATAEKMHAIFLEIIIAPSYTDEALAILTTKKKNLRILQLPFDAQEASEAEKEYTGVVGGLLVQNQDVVKESPADWQVVTKRQPTKTEETALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRIAIDQAKDRLDGAVLASDAFFPFADNVEEIAAAGIKAIIQPGGSVRDQESIDMADKYGIAMVFTGVRHFRH","42936","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0028 (purF),(purB) ; SMu0030 (purM); SMu0031 (purN); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0054 (purB); SMu0243 (purA); SMu0321 (purR). ","phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase","Cytoplasm","Numerous matches in gapped BLAST to purH sequences. Residues 6-520 are 91% similar to the enzyme from S.pneumoniae (gi15899995) and are 85% similar to the enzyme from S.suis (gi12082200).This sequence is similar to Spy0030.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0030 (0.0).","

InterPro
IPR002695
Family

AICARFT/IMPCHase bienzyme
PD004666	$\"[64-198]T$	PUR9_STRMU_Q8DWK8;
PTHR11692	$\"[4-520]T$	BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN
TIGR00355	$\"[8-520]T$	purH: bifunctional purine biosynthesis prot

InterPro
IPR011607
Domain

MGS-like
PF02142	$\"[19-134]T$	MGS

InterPro
IPR013982
Domain

AICARFT/IMPCHase bienzyme, formylation region
PF01808	$\"[139-455]T$	AICARFT_IMPCHas
SM00798	$\"[139-455]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.140.20	$\"[243-367]T$ $\"[369-520]T$	no description
G3DSA:3.40.50.1380	$\"[3-191]T$	no description

","BeTs to 8 clades of COG0138COG name: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)Functional Class: FThe phylogenetic pattern of COG0138 is a---Yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB002695 (AICARFT/IMPCHase bienzyme) with a combined E-value of 2e-235. IPB002695A 10-41 IPB002695B 48-82 IPB002695C 100-113 IPB002695D 123-155 IPB002695E 173-195 IPB002695F 217-230 IPB002695G 240-255 IPB002695H 295-324 IPB002695I 326-352 IPB002695J 376-386 IPB002695K 413-451 IPB002695L 464-498 IPB002695M 499-520","Residues 460-520 are 75% similar to a (IMP PURINE) protein domain (PD004903) which is seen in Q9F1T4_STRSU.Residues 11-138 are 83% similar to a (IMP PURINE BIOSYNTHESIS SYNTHETASE) protein domain (PD002195) which is seen in Q9F1T4_STRSU.Residues 139-455 are 84% similar to a (IMP PURINE) protein domain (PD004666) which is seen in Q9F1T4_STRSU.Residues 461-520 are 40% similar to a (CG11089) protein domain (PD258711) which is seen in Q9VC18_DROME.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 8 09:11:18 2006","Thu Oct 24 17:12:29 2002","Wed Feb 8 09:11:18 2006","Thu Mar 28 13:26:21 2002","Wed Dec 5 14:56:32 2001","Wed Dec 5 14:56:32 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0033 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 13:26:21 2002","","No significant hits to the NCBI PDB database.","SMU.37","","Residues 10 to 134 (E-value = 4.9e-50) place SMu0033 in the MGS family which is described as MGS-like domain (PF02142)Residues 139 to 455 (E-value = 4.4e-142) place SMu0033 in the AICARFT_IMPCHas family which is described as AICARFT/IMPCHase bienzyme (PF01808)","Wed Feb 8 09:11:18 2006","24378565","","","Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA.Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.Nat Struct Biol. 2001 May;8(5):402-6.PMID: 11323713 Saxild HH, Nygaard P.Gene-enzyme relationships of the purine biosynthetic pathway in Bacillus subtilis.Mol Gen Genet. 1988 Jan;211(1):160-7.PMID: 3125411","","Wed Dec 5 15:03:15 2001","1","","3","SMU.37","7" "SMu0034","43664","43122","543","ATGGAATATCAAACACGGCAATGGCTGGAGGAAGCCTTGTTCGATTTATTAGCAACTAAGAAATCCCTGCATAATATCAGCATTGCAGAACTCAGCGAGCATGCCCAGATTGCTAGACGAACGTTTTATCGTTATTACCATTCAAAAGAGCAAGTCCTTACGAACTATTTAGACCGCTTAATCCAAGACTATATTATCGAACTTCAAACAGAAAAACTGACTAATTTTGAAGATTTAGTGAATCTTTTCTTTCAGTATTGGAGCCAGTACACTGAGTCATTAAAAATTTTGCAGGAAGCAAACCTGCTAGTGCTTATCTTGCAAAGGTATTATGATAAGCTTCCTGCTGCTTATACCACTGTCATGGCACCTTGGCACATCACAAACAGTGATCAAAGACAAATCTCCTATGATAGTAGATTCATTATCGGCGGTCTCTACAGTATTTTTGATGAATGGTTAAAAACAGATCACCAAACAATGCCTGTTAATGAACTGGTCACTACAGCCTTAAACACCATAAAACGTATGAAGGATAGTTAA","5.70","-3.80","21562","MEYQTRQWLEEALFDLLATKKSLHNISIAELSEHAQIARRTFYRYYHSKEQVLTNYLDRLIQDYIIELQTEKLTNFEDLVNLFFQYWSQYTESLKILQEANLLVLILQRYYDKLPAAYTTVMAPWHITNSDQRQISYDSRFIIGGLYSIFDEWLKTDHQTMPVNELVTTALNTIKRMKDS","43125","","AcrR/TetR related transcriptional regulator","Membrane, Cytoplasm","Matches in gapped BLAST to AcrR and TetR family transcriptional regulators. Residues 4-160 are 30% similar to the transcriptional regulator from Clostridium acetobutylicum (gi|15894011). Residues 5-176 are 27% similar to a predicted TetR family regulator from S.pneumoniae (gi|15900638).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1310 (2e-17).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[9-53]T$	TetR_N
PS50977	$\"[3-64]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[2-70]T$	Homeodomain_like

","BeTs to 5 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class:� KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 5e-08. IPB001647 22-52","Residues 4-159 are 24% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD106875) which is seen in Q9CDI1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:17:02 2002","Wed Dec 5 15:08:57 2001","Mon Oct 7 15:01:29 2002","Wed Dec 5 15:08:57 2001","Wed Dec 5 15:08:57 2001","Wed Dec 5 15:08:57 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0034 is paralogously related (blast p-value < 1e-3) to SMu1069.","Mon Oct 7 15:01:29 2002","","No significant hits to the NCBI PDB database.","SMU.38c","","No significant hits to the Pfam 11.0 database","Wed Dec 5 15:08:57 2001","24378566","","","","","","1","","3","SMU.38c","" "SMu0035","43832","44341","510","ATGAGCATTCTTTTTAATGTTTGGATGCTGCCTATTTTATTTATTTTACATGATTTTGAAGAAATGATCTTTATGCCCTTGTGGAAAAAACGGCATCATCAAAAGTTAGTGACTTTTAAAAAACCGTTCTTTGGTTCTGTTACGCAGGGTTCTGCCTTTGCAGTAGGCGTTTTAGAGGAATTTGTCATCTTGCTGCTTATTTCTGGTCTTTGTCAAATGACCCACAATACCTTACTCTATTTATCTTTTGTAATAGCTTATACATCTCATTTCACGATCCATTATATCATGTGCCTGCGATTTAAGGGCTATGTTCCCGGAGTCGTCACGGCAAGCTTAGAATTGCCAATTGTTTTAATGATTATTTTCTGCTATTGGCCTTCTGACATTTCCCTGCTGTCAGTCATTGTCTATCTTTTCATAGCTATGGCAATAGCTTATACTAATCTTAAAGTTATGCACCAAATCATGCCAAAAATTCAATTAAGCCTAGAAAAATACATGAAATAA","9.30","5.52","19649","MSILFNVWMLPILFILHDFEEMIFMPLWKKRHHQKLVTFKKPFFGSVTQGSAFAVGVLEEFVILLLISGLCQMTHNTLLYLSFVIAYTSHFTIHYIMCLRFKGYVPGVVTASLELPIVLMIIFCYWPSDISLLSVIVYLFIAMAIAYTNLKVMHQIMPKIQLSLEKYMK","44338","","conserved hypothetical protein","Membrane, Cytoplasm","Single match in gapped BLAST to a hypothetical protein. Residues 1-167 are 28% similar to a predicted membrane protein in Clostridium acetobutylicum (gi|15894009). SMu0035 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-15]?$	signal-peptide
tmhmm	$\"[10-28]?$ $\"[49-69]?$ $\"[79-99]?$ $\"[104-124]?$ $\"[130-150]?$	transmembrane_regions

InterPro
IPR007712
Family

Plasmid stabilization system
PF05016	$\"[10-51]T$	Plasmid_stabil

","BeTs to 3 clades of COG2026COG name: Uncharacterized ACR, RelE homologFunctional Class:� SThe phylogenetic pattern of COG2026 is AM-K---ce------------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:02:31 2002","Wed Dec 5 15:16:29 2001","Mon Oct 7 15:02:31 2002","Wed Dec 5 15:16:29 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0036 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:02:31 2002","","No significant hits to the NCBI PDB database.","SMU.40","","No significant hits to the Pfam 11.0 database","Wed Dec 5 15:16:29 2001","24378568","","","","","","1","","3","SMU.40","" "SMu0037","44663","44764","102","ATGTTTATAAGAAGTAAGCTGAGAAGGGTGGATTTTTCAGGTGTACGTCGTGGCAATAAGCATTTCCTTCTTGACAAATTACTGATAACTTTAGTAAAATGA","12.40","7.21","3940","MFIRSKLRRVDFSGVRRGNKHFLLDKLLITLVK","44761","Fragment?","hypothetical protein","Extracellular, Cytoplasm","No significant hits in gapped BLAST.SMu0037 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:03:04 2002","Wed Dec 5 15:23:03 2001","Mon Oct 7 15:03:04 2002","Wed Dec 5 15:23:03 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","No paralog in S.mutans.SMu0037 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:03:04 2002","","No significant hits to the NCBI PDB database.","SMU.41","","No significant hits to the Pfam 11.0 database","Wed Dec 5 15:23:03 2001","24378569","","","","","","1","","3","SMU.41","" "SMu0038","44831","45709","879","ATGGAAATCAAAGAATTTAAGACTTTTGAAGAGCAGGTAGCCAAATTAATTGAGCACGGATGTGAGGATATAACTTCCAAGGAGTATGCCATCACTATTCTAAAACGTATTAATTATTATCGGTTAACTGCTTATTTTTTGCCTTTTAGAGATGAGGAGTCTCAAAAATATGACAGCAACAAGGTATCTTTAGAGAAGATTTACAGCATTTATCAGTTTGATTCAGAGCTCAGACTTTTGCTAATGGAGTATCTTGAAGATATTGAGTTATATTTTAAAACGCAAGTTGCTTACCATCATTCTGAACAGTATGGCGCCTTAGCTTATAAATATAGCAAGAACTTTAACAAATATCACAAACACGATGAATTTATGAAGAATCTTGAAAAAGAACTGAGTTATCGAAGAAAGGATCCTATTTATAAACATCATCAGTTTAAGTATGATGGTGAATTTCCCTTATGGGTCTTAGTTGAATTTTTTTCATTTGGTATGACTTCTAAGTTTTATGCCGATAGTCCAAATTCAGTTCAAAGTCTCATTGCTAAAGATTTGAATATCAAGATAACTCAAGTTCGTACCTACCTTGAAGTTGCAGTTGTTCTTAGAAACTATTGCGCACATTACAGTAGGCTGTACTATAGAAGCTTCACAAAGGTTCCTGGACAGCTGCCACCTTTTATGACTGAAAATGTCAAAATTAAAAATCGCCTCATGGCTCAATTATATGCCATTAAACAGTTGTATACTGATCGTGATAAATGGAATAATAATTTTATCCCACGTTTAAGAGGCTTATTTGCTAAATACCAATCCAGTATTCATCTACATCACTTAGGTTTTACAGGTGACTGGGAATATGTTTTGAAGAATAAATAG","9.80","9.56","35317","MEIKEFKTFEEQVAKLIEHGCEDITSKEYAITILKRINYYRLTAYFLPFRDEESQKYDSNKVSLEKIYSIYQFDSELRLLLMEYLEDIELYFKTQVAYHHSEQYGALAYKYSKNFNKYHKHDEFMKNLEKELSYRRKDPIYKHHQFKYDGEFPLWVLVEFFSFGMTSKFYADSPNSVQSLIAKDLNIKITQVRTYLEVAVVLRNYCAHYSRLYYRSFTKVPGQLPPFMTENVKIKNRLMAQLYAIKQLYTDRDKWNNNFIPRLRGLFAKYQSSIHLHHLGFTGDWEYVLKNK","45706","","conserved hypothetical protein","Cytoplasm","Some weakish matches to hypothetical proteins. Residues 22-287 are 28% similar to an unknown from P.multocida (gi|15603648). Residues 3-213 are 28% similar to a hypothetical from S.aureus (gi|15923791).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0605 (5e-13).","

InterPro
IPR011664
Family

Abortive infection bacteriophage resistance related
PF07751	$\"[4-212]T$	Abi_2

noIPR
unintegrated

unintegrated
PIRSF034934	$\"[3-292]T$	AbiF_AbiD

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-169 are 28% similar to a (PXO1-38 PLASMID) protein domain (PD317212) which is seen in Q9X309_BACAN.Residues 22-266 are 28% similar to a (PROTEOME COMPLETE PM1783 PM1540) protein domain (PD416133) which is seen in Q9CK51_PASMU.Residues 2-285 are 24% similar to a (PLASMID INFECTION LACTIS ABID) protein domain (PD024695) which is seen in Q48717_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:03:43 2002","Wed Dec 5 15:27:07 2001","Mon Oct 7 15:03:43 2002","Wed Dec 5 15:27:07 2001","","Wed Dec 5 15:27:07 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralog in S.mutans.SMu0038 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:03:43 2002","","No significant hits to the NCBI PDB database.","SMU.42","","No significant hits to the Pfam 11.0 database","Wed Dec 5 15:27:07 2001","24378570","","","","","","1","","3","SMU.42","" "SMu0039","45781","47160","1380","ATGAAAAAATTTCAAGTATTCACCCCTTCTCAATATGTTGAGCAGATGCTAGATGAAGTTGGTTACCAAGGTGTAGGAATTTTGAAGAAAACGTTTCTGGAAAATTCAGTTGGTGAAGGTAACATTTTATTAACAGCGGTTAAGCGCTATATAGTTGTTGCAAAGAAAGAAAAATATTCATGGAAGGAAATTAAGTCTGATTTAGAAAAGTATTTTGTGGGATTTGAAGTAGATGAAATTGTATTGGATACATGTATAAAAAGATTAAATCAGTTGGTTGCAGAATATGAAATAAAAGGTGTTAAGTGGAATATTAGAAAAGAGGATTATTTAAAATCATCCATTGAAATTCGGGCAGATTATATTGTTGGAAATCCACCATATATTACGTATCAAGAATTAAAAGAAGTAGATAGAGTATATTTAAAAGAAAATTTTATATCTTGTCGTAAAGGGAAGTTTGATTATTGTTATGCTTTTGCTGAGAAAAGTTTGAAAGATTTATCTGAAATAGGGAAGTTAGTGTATTTAATCCCTAACAGTATATTTAAAAATGTTTTTGCCCAAAATTTAAGGAATCTCATAATTGATAATTTAATGAAAATTATTGATTATAAACATACTCATATATTTGAAAAAGTACTAACTTCATCATCAATTATCGTAATAAATAAGAATGTATATAAAAGGAAATTTGAATACATAGATGTTGATTTTCAAAAGAATTTTTTTGTAGATAAAGTCCTTTTACAAAATAAATGGTATTTTTTTGAGGAACATATCAAACAAAATAACAAAGAGACTATATTGTTTGGTGAGTTGTTCAAGGTGGCTAACAGCGTAGCTACGTTGTCTAATAAAGTATTTGTAATATCTGAAGAAACAGCACTGGAAAATGAGGTAATCAGGCCGGCTGCAAGTCCACGAAAATTCGCTAAGAATATTGCTGAAAGAATTATTTTTCCTTATAAATATGAAAATGCAAACCTTATAAGGTACTCAAAGGAAGAATTTGAAATGAACTTTCCTAAAGCAACCAGTTATCTTAGGGAACAGAAGAAAATTTTAGATAAAAGAAAATCAGATGGTGAGTGGTTTGAATATGGACGATCTCAGGGTCTAAAATTTATGAACCAGGCAAAATTGATGATCTCATCAGTAATTACAGAAAAAATTCATGTTTATGAATTAGATGCTCAAACAATTCCCTATTCGGGATTCTATATTATACCAATAGCAGAAAAGTCTTTGGATTTTGCTAAAGAAATCCTTGAATCAAAAGAGTTCTATAATTATCTGGAAACGCGAGCGATCAATGCAAGTGGAAAATCAATACGTATATCTGTGAATGATGTAAAAAATTATCCAATAAAAGTATGA","9.70","10.87","53965","MKKFQVFTPSQYVEQMLDEVGYQGVGILKKTFLENSVGEGNILLTAVKRYIVVAKKEKYSWKEIKSDLEKYFVGFEVDEIVLDTCIKRLNQLVAEYEIKGVKWNIRKEDYLKSSIEIRADYIVGNPPYITYQELKEVDRVYLKENFISCRKGKFDYCYAFAEKSLKDLSEIGKLVYLIPNSIFKNVFAQNLRNLIIDNLMKIIDYKHTHIFEKVLTSSSIIVINKNVYKRKFEYIDVDFQKNFFVDKVLLQNKWYFFEEHIKQNNKETILFGELFKVANSVATLSNKVFVISEETALENEVIRPAASPRKFAKNIAERIIFPYKYENANLIRYSKEEFEMNFPKATSYLREQKKILDKRKSDGEWFEYGRSQGLKFMNQAKLMISSVITEKIHVYELDAQTIPYSGFYIIPIAEKSLDFAKEILESKEFYNYLETRAINASGKSIRISVNDVKNYPIKV","47157","","conserved hypothetical protein (possible site-specific DNA-methyltransferase/restriction modification enzyme)","Cytoplasm, Extracellular","Matches to conserved hypotheticals and to type II restriction enzymes. Residues 118-327 are 27% similar to an unknown from U.urealyticum (gi|13357592). Residues 120-459 are 23% similar to a predicted methylase subunit from Clostridium acetobutylicum (gi|15896771). Residues 6-446 are 22% similar to MTV1_BACST (gi|1171062)(EC = 2.1.1.72).SMu0039 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[122-128]?$	N6_MTASE

InterPro
IPR002296
Family

N6 adenine-specific DNA methyltransferase, N12 class
PR00507	$\"[4-20]T$ $\"[32-46]T$ $\"[119-131]T$ $\"[155-179]T$	N12N6MTFRASE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[6-226]T$	G3DSA:3.40.50.150
SSF53335	$\"[6-457]T$	SSF53335

","BeTs to 4 clades of COG0827COG name: Adenine-specific DNA methyltransferasesFunctional Class:� LThe phylogenetic pattern of COG0827 is -M-------brhUJ-Po----Number of proteins in this genome belonging to this COG is 1","***** PR00507 (N12 class N6 adenine-specific DNA methyltransferase signature) with a combined E-value of 5.2e-12. PR00507A 4-20 PR00507B 32-46 PR00507C 119-131 PR00507D 155-179","Residues 120-206 are 43% similar to a (METHYLTRANSFERASE RESTRICTION METHYLASE) protein domain (PD011355) which is seen in P71445_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:18:22 2002","Tue Oct 8 16:18:22 2002","Mon Oct 7 15:04:42 2002","Wed Dec 5 15:28:00 2001","Wed Dec 5 15:28:00 2001","Wed Dec 5 15:28:00 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0039 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:04:42 2002","","No significant hits to the NCBI PDB database.","SMU.43","","No significant hits to the Pfam 11.0 database","Wed Dec 5 15:28:00 2001","24378571","","","","","","1","","3","SMU.43","" "SMu0040","47171","47782","612","ATGGCTAAAATAGTGAAAGAAGCGAGTTTCAAATCAACAACAAGAACTGTAAACCTTCTAGGGAGAGAGAATGTACTAGATTACAGAAGTGCAATATTGGAATTAGTGAAAAATAGCTATGATGCATTTTCGAATCAAGTAAATATTCGAATAATTGGAAAAGATATTACTATTAATAAAAAAAAGGACAAAAGAGCTACTTCGATAGAAATAATTGACTATGGTCAAGGTATGAGTTTGGATAAAATTATTAATGTCTTTTTTACATTAGGAACTGATGATAAAACTTATACTACTTCAATAAAATACCAAGAGTCTGAGCGTGTGATGAATGGTTCTATGGGAATTGGTAGATTATCACTTGGCAGACTGGGAAATATAAGCTGTGTTATTACTTCAGATGGTAGCGAAGCCTATAGATTTAGTATAAATTGGAATAGCTTCATAACAGGAGAATCTTTAGATACTGTAAAGGTAGATATAGAACAGTTGTCAATGAGTGAGTTTGCCTCAGAGTATACAAACAGAGGTTTAGAAAATAAAAAGTGTACAGGTACAATTTTAATAGCCAGCGAGCTGAAAGATGAATGGTTGCTATCAGATAAGGGTTAG","6.70","-0.09","22700","MAKIVKEASFKSTTRTVNLLGRENVLDYRSAILELVKNSYDAFSNQVNIRIIGKDITINKKKDKRATSIEIIDYGQGMSLDKIINVFFTLGTDDKTYTTSIKYQESERVMNGSMGIGRLSLGRLGNISCVITSDGSEAYRFSINWNSFITGESLDTVKVDIEQLSMSEFASEYTNRGLENKKCTGTILIASELKDEWLLSDKG","47779","","conserved hypothetical protein","Cytoplasm, Membrane","Two weak matches to hypothetical proteins. Residues 31-196 are 30% similar to an unknown from Y.pestis (gi|16120726). Residues 31-193 are 25% similar to gi|15793433 from N.meningiditis.SMu0040 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
SM00387	$\"[23-149]T$	HATPase_c
SSF55874	$\"[3-152]T$	ATP_bd_ATPase

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 31-193 are 25% similar to a (RESTRICTION PROTEOME HGIDIIM SYSTEM) protein domain (PD360240) which is seen in Q9JWD7_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:05:17 2002","Wed Dec 5 15:36:21 2001","Mon Oct 7 15:05:17 2002","Wed Dec 5 15:36:21 2001","","Wed Dec 5 15:36:21 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralog in S.mutans.SMu0040 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:05:17 2002","","No significant hits to the NCBI PDB database.","SMU.44","","No significant hits to the Pfam 11.0 database","Wed Dec 5 15:36:21 2001","24378572","","","","","","1","","3","SMU.44","" "SMu0041","47969","49570","1602","ATGTTAGTCTTAGATGGGTATTTTGATGAAATTGTTATTAATCAATTACCGCCGGATTTTGTAAATGCGAAATTCGATAAACTAAAAAATTATATTCAAGATGATACTGGTAAAAAAAGAAGTAGATACCATTTTGAACGAGAGTTTAAAATTTCAGAGTATATTCCTTATAATATACCTAATAATCCGATAGGAGATTTTGACGGAGTATTATATTTTACAAAAAAAAGAAGAACTGGGGGAAATTATCCTTTTATTAAAGATGCAATACGTACTAATACATTTGATATCGAACCTGGAATTTTATTGTATAGAGATGGTTTTAGGATTAGACCCTATGGAGAAATTGATACTATAGGGTTTGACTGGATAGGAATTGAAAAAGAAAGAACTAAAAATCCCGCTGGTGTTAGTCGCAGTAGCTATATAATGCAAGCAAATCAGTTGAGTGGTTATGTAAATATCACTAAGGAAAAAAATGGAGGCTTTGAAGATCAAGCTAATCGTGAAGGTTTAAAAAATAGTGCAGAGTTTGAATATCTTGAGAGTGTTATTCTCAGAATTGTAAAAGATTTTTCTTCAATACGTTCAGAAATTATTATTTTGTATAATGACTTTTTAAAGGAACAAGCAAATGTACAACACTTTAGTGAAGAAGGAAAAAAAACAAAGAAAAAATTAGATAGTCTTGTTAACAAACATCAAGGTAACTTAAAAGAATTATATCGAGATCCAGAATATGAAGCATTAGTTTCTAATCCACAATCATTATTTGAAATGTATTCGTTACAGGATACCACGGCTGAAGAAAACAGTTCACTTGTTAGTGAGAGTGATACGCTACGAACTATGGCAACTCAAGGTATTGTTATGTCAACTTTTGCGCATCAAATTAAGAATGATAAGATGTTCTTTAAAACGATTCCTCAAAATTTAAAAGATATAGGAGACCATTATTCAAAACTTTTTAAGTCGGATTTTCATGAAATTAAGAAACGGTATAATTTATACAACTTTTCAGAAGCGGTTGAACGAAAAACAACCAATATATTAGGGTTCATAGAAAGTAGTGTTAATAATCCAACAAGGGATAAGAAAGAAAAAATTAATCTACCTTCTTATCTTTTTAAAGTTTATTCTTGGTGGGATAATTCAATAAGAGATAATTTTTATTCGTATGACTATTTGGTCAATGGTAAATCTTCCTTGGAAGCTTTACCTGAGACAATAAAAAATATTTATGTTTATGCAAGTGAAACACAGTTAGATAGTATTTTCCTAAATTTAATAACTAATTCTTATAAAAGTTTTAAATCTCCAGATAAAATCAACCCTAGAGTTATCAATATTTCCTTAGAAGTTATGGAGGATACACTAATTAAGATTACCTATGAAGATAATGGCAATGGTTTAAATAAGAAAATTGAAAATCCAAATACGATTTTTGAAGCATATAAATCTTATAATAAAGGTGGAACTGGAATGGGAATGTCAATTTTAGCCTCAGTTATATCTAATTTAAAAGGAGATAAAGAATTATTATCTAAGCCTGGGGAAAGAGGGTTTAAAATTAAAATGACTTTAAAAGGTGGAATAAAATAA","9.00","3.50","61510","MLVLDGYFDEIVINQLPPDFVNAKFDKLKNYIQDDTGKKRSRYHFEREFKISEYIPYNIPNNPIGDFDGVLYFTKKRRTGGNYPFIKDAIRTNTFDIEPGILLYRDGFRIRPYGEIDTIGFDWIGIEKERTKNPAGVSRSSYIMQANQLSGYVNITKEKNGGFEDQANREGLKNSAEFEYLESVILRIVKDFSSIRSEIIILYNDFLKEQANVQHFSEEGKKTKKKLDSLVNKHQGNLKELYRDPEYEALVSNPQSLFEMYSLQDTTAEENSSLVSESDTLRTMATQGIVMSTFAHQIKNDKMFFKTIPQNLKDIGDHYSKLFKSDFHEIKKRYNLYNFSEAVERKTTNILGFIESSVNNPTRDKKEKINLPSYLFKVYSWWDNSIRDNFYSYDYLVNGKSSLEALPETIKNIYVYASETQLDSIFLNLITNSYKSFKSPDKINPRVINISLEVMEDTLIKITYEDNGNGLNKKIENPNTIFEAYKSYNKGGTGMGMSILASVISNLKGDKELLSKPGERGFKIKMTLKGGIK","49567","","hypothetical protein","Cytoplasm, Membrane","Several weak matches to two-component sensor histidine kinase sequences. E.g. residues 220-529 are 24% similar to gi|15893582 of Clostridium acetobutylicum.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0624 (3e-10).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[374-529]T$	ATP_bd_ATPase
PF02518	$\"[417-531]T$	HATPase_c
SM00387	$\"[417-532]T$	HATPase_c
SSF55874	$\"[375-529]T$	ATP_bd_ATPase

InterPro
IPR004358
Domain

Histidine kinase related protein, C-terminal
PR00344	$\"[460-474]T$ $\"[491-509]T$	BCTRLSENSOR

noIPR
unintegrated

unintegrated
PTHR23283	$\"[413-519]T$	PTHR23283
PTHR23283:SF24	$\"[413-519]T$	PTHR23283:SF24

","BeTs to 10 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class:� TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 415-509 are 34% similar to a (KINASE TRANSDUCTION TRANSFERASE) protein domain (PD125954) which is seen in Q9PMH0_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:06:02 2002","Wed Dec 5 15:47:09 2001","Wed Jan 9 14:01:42 2002","Wed Dec 5 15:44:26 2001","","Wed Dec 5 15:44:26 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralog in S.mutans, however this sequence is very weakly similar to SMu1652, a predicted histidine kinase.SMu0041 is paralogously related (blast p-value < 1e-3) to SMu1652.","Wed Jan 9 14:01:42 2002","","No significant hits to the NCBI PDB database.","SMU.45","","Residues 417 to 531 (E-value = 1.3e-08) place SMu0041 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Wed Dec 5 15:44:26 2001","24378573","","","","","","1","","3","SMU.45","" "SMu0042","49572","50207","636","ATGTTTGATAAAAAAAGAATTTATTATATTGATGATGATGAAGATACTATGTATACATTAGGGGAATTAGAGAAAAAATTTTCTAAAAAGGGCTATAGTGTTGAATTTTTAGGAATAATAAATGAAGAATCAAAGGAAAAATTCTTGGAAAAACTATATTCACAAGAAAAATATGGAATTATTTTGGACTATGATTTAACTAATAGTAATATTTATGGTGATGCTATTGAATTATGGCAAACTATTAAAAAGCAAAATCCTCTTTTTCCTGTTTGTATATATACTTCACATAGTGATGATGTCCAAATTGATCCATTAGTAGAGAAGAAATTTTCTAAAGATGGATACTCTTTAAATGGAGAGGTATTCACCAAGGAAGATGAAATAGATAGTATGTTAGAATATATTGATGAGCAAGTTAAGTTAGGGATAGAAAACATCAATACACTAGAGAGAGTAAATCAAGGTTTAAAGAAGTCTGATGCTTTTTCGACGGAAGTAGCAATTAATGAAACTAAAATAGAACACCAATTTTCTATTAATCAACCTCGACTTTTAAATAATGATGTTGCTGATCGTTTAGACAATTTAATAGCAAAAGCCTATAAAATTATTGATGAATCAGGAGATATATAG","4.40","-16.54","24499","MFDKKRIYYIDDDEDTMYTLGELEKKFSKKGYSVEFLGIINEESKEKFLEKLYSQEKYGIILDYDLTNSNIYGDAIELWQTIKKQNPLFPVCIYTSHSDDVQIDPLVEKKFSKDGYSLNGEVFTKEDEIDSMLEYIDEQVKLGIENINTLERVNQGLKKSDAFSTEVAINETKIEHQFSINQPRLLNNDVADRLDNLIAKAYKIIDESGDI","50204","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0042 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[6-125]T$	Response_reg

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[2-103]T$	CheY_like

InterPro
IPR002711
Domain

HNH endonuclease
PF01844	$\"[48-101]T$	HNH

InterPro
IPR003615
Domain

HNH nuclease
SM00507	$\"[37-95]T$	HNHc

InterPro
IPR000115
Domain

Phosphoribosylglycinamide synthetase
PF01071	$\"[103-294]T$	GARS_A
PF02843	$\"[327-419]T$	GARS_C
PF02844	$\"[1-101]T$	GARS_N
TIGR00877	$\"[1-419]T$	purD
PS00184	$\"[288-295]T$	GARS

InterPro
IPR011054
Domain

Rudiment single hybrid motif
SSF51246	$\"[325-419]T$	Rudmnt_hyb_motif

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[108-314]T$	ATP_GRASP

InterPro
IPR013815
Domain

ATP-grasp fold, subdomain 1
G3DSA:3.30.1490.20	$\"[120-189]T$	ATP_grasp_subdomain_1

InterPro
IPR013816
Domain

ATP-grasp fold, subdomain 2
G3DSA:3.30.470.20	$\"[190-327]T$	ATP_grasp_subdomain_2

InterPro
IPR013817
Domain

Pre-ATP-grasp fold
G3DSA:3.40.50.20	$\"[1-94]T$	Pre-ATP_grasp

noIPR
unintegrated

unintegrated
PTHR10520	$\"[104-419]T$	PTHR10520
PTHR10520:SF3	$\"[104-419]T$	PTHR10520:SF3
SSF52440	$\"[1-102]T$	SSF52440
SSF56059	$\"[103-325]T$	SSF56059

","BeTs to 12 clades of COG0151COG name: Phosphoribosylamine-glycine ligaseFunctional Class: FThe phylogenetic pattern of COG0151 is amtkyqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000115 (Phosphoribosylglycinamide synthetase) with a combined E-value of 5.4e-124. IPB000115A 2-31 IPB000115B 64-111 IPB000115C 142-156 IPB000115D 212-236 IPB000115E 254-275 IPB000115F 280-305 IPB000115G 328-348 IPB000115H 400-419","Residues 224-418 are 78% similar to a (LIGASE SYNTHETASE) protein domain (PD002812) which is seen in Q9F1S9_STRSU.Residues 1-82 are 86% similar to a (LIGASE SYNTHETASE) protein domain (PD002771) which is seen in Q9F1S9_STRSU.Residues 208-288 are 64% similar to a (LIGASE SYNTHETASE CARBOXYLASE COMPLETE PROTEOME) protein domain (PD000180) which is seen in PUR2_CHICK.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 8 09:26:29 2006","Fri Dec 7 10:54:59 2001","Wed Feb 8 09:26:29 2006","Thu Mar 28 13:27:17 2002","Fri Dec 7 10:54:59 2001","Fri Dec 7 10:54:59 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans, however this sequence is weakly related to SMu1206, a conserved hypothetical.SMu0044 is paralogously related (blast p-value < 1e-3) to SMu1206.","Wed Jan 9 14:18:39 2002","Wed Feb 8 09:26:29 2006","pdb1GSOA Chain A, Glycinamide Ribonucleotide Synthetase (Gar-... 337 1e-093","SMU.48","","Residues 1 to 101 (E-value = 3.8e-38) place SMu0044 in the GARS_N family which is described as Phosphoribosylglycinamide synthetase, N domain (PF02844)Residues 103 to 185 (E-value = 8.2e-43) place SMu0044 in the GARS_B family which is described as Phosphoribosylglycinamide synthetase, B domain (PF02842)Residues 186 to 322 (E-value = 1e-80) place SMu0044 in the GARS_A family which is described as Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain (PF01071)Residues 327 to 419 (E-value = 1.1e-11) place SMu0044 in the GARS_C family which is described as Phosphoribosylglycinamide synthetase, C domain (PF02843)","Wed Feb 8 09:26:29 2006","24378576","","","Kilstrup M, Jessing SG, Wichmand-Jorgensen SB, Madsen M, Nilsson D.Activation control of pur gene expression in Lactococcus lactis: proposal for a consensus activator binding sequence based on deletion analysis and site-directed mutagenesis of purC and purD promoter regions.J Bacteriol. 1998 Aug;180(15):3900-6.PMID: 9683487","","Fri Dec 7 12:02:10 2001","1","","3","SMU.48","8" "SMu0045","52358","53539","1182","ATGAAAAACAGACTGCTATTTTTAGAAGGTTCTAGCTTAACTTCAAGAGAGACTCTAACAGTATTGCTAAAAGAGGGCTACAAAGTTGATGTCCTGTCTCCTGATAAGTTTTCTATTGCAACATTCAGTCGACTCACTCATAGAATTCCGACAGTTGATGTAAATCGTTTTCCTTTAGATTACTTGAAACAAGTTAATCAGCTGCTTCATCAAAAAAATTATGCAGCTATTTTGCCGACACATGAGGAAGGCTGGTTATTGGCAAATGGGGGAAATTTTTTACCAACTCGTTTGCCAGTAGCGCTTGCTGATAAGGAACAAATTGAAAAGCTGGCTGGGAAGATTGCGTTTGCTGAAATTTCGGATCAGTTAAATCTGCCAATTCCTAAATGGGAGCGTGTGGAAAATTTAGAATCTGTTTCTCTTCCTTATCCTTATTGGCTAAAGGCAGACTATGGTACTGCCGGTCGTTCGGTTTATAAAATCACAAGTAAGGAAGATTTGGCGGAAGCTGCGAGCAGATTAACAGCGAGTGATGAAAAATGGATGGTTCAGCAAGACATAGTCGGAGACTATGGTCAGGTTCAAGCAGTATTTCATCATGGTCAGTTACTTGCGGTTCATTCTAGTGTTAAAGTGGGTTCTGGTGCCGGTGGTTCAGCTGCTGCTAGATTAAGTATAGAATCTGAGAAAACGAGAGAGCATGTCGAAAAATTAGGTCAATTTTTACAATGGCATGGTGCTTTAACTTTAGATTTTATACGTACCGACGGTCATTTTTATTACATAGAGTGCAATCCTAGAATGGTTGAACCTGCTAATGCCTACAAAGCAGGAGTTAACTTCCCAAAAATCATGATAGAGTTAGCCAATGGCTGCTATTCTAAATCTGATGTTAGTGTTGGGCAAGCAGGGGTAGGGACGCATAGCCTGATGGCTTTGCTTATCGGTACTGCTGAGCGAACGAAGAGTAGAAAGAAGATTGTACGGACAATGAGAAAGTGGCTTTTTAACAGTGACAGTGAAGAGGTGTTAACACCTATTTGGAAGGATCCTCTAAGTTTTATACCTCTTGCGATTATTATCGGTCGCTTATTGATAAATCCTAGAAGTGTCACCAAGTTGGTTGATAAGACCGTTAAACATTATAGTGTGGAACCGACCACTCTAAAAAATATTTGA","9.70","8.57","43932","MKNRLLFLEGSSLTSRETLTVLLKEGYKVDVLSPDKFSIATFSRLTHRIPTVDVNRFPLDYLKQVNQLLHQKNYAAILPTHEEGWLLANGGNFLPTRLPVALADKEQIEKLAGKIAFAEISDQLNLPIPKWERVENLESVSLPYPYWLKADYGTAGRSVYKITSKEDLAEAASRLTASDEKWMVQQDIVGDYGQVQAVFHHGQLLAVHSSVKVGSGAGGSAAARLSIESEKTREHVEKLGQFLQWHGALTLDFIRTDGHFYYIECNPRMVEPANAYKAGVNFPKIMIELANGCYSKSDVSVGQAGVGTHSLMALLIGTAERTKSRKKIVRTMRKWLFNSDSEEVLTPIWKDPLSFIPLAIIIGRLLINPRSVTKLVDKTVKHYSVEPTTLKNI","53536","","hypothetical protein","Cytoplasm","Limited and weak matches to carbamoyl-phosphate synthases: residues 98-287 are 22% similar to the enzyme from Leishmania mexicana (gi|7544108)(EC 6.3.4.16).SMu0045 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[118-291]T$	ATP_GRASP

noIPR
unintegrated

unintegrated
SSF56059	$\"[113-292]T$	SSF56059

","BeTs to 7 clades of COG0439COG name: Biotin carboxylaseFunctional Class: IThe phylogenetic pattern of COG0439 is amt-YQ-CeBRhuj----inxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 25 13:15:24 2002","Thu Apr 25 13:15:24 2002","Fri Dec 7 12:23:21 2001","Thu Apr 25 13:15:24 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","No definite paralogs in S.mutans, however a weak similarity to SMu1582, also related to carbamoyl-phosphate synthase (E-04).SMu0045 is paralogously related (blast p-value < 1e-3) to SMu1582.","Wed Jan 9 14:19:25 2002","","No significant hits to the NCBI PDB database.","SMU.49","","No significant hits to the Pfam 11.0 database","Fri Dec 7 12:22:31 2001","24378577","","","","","","1","","3","SMU.49","" "SMu0046","53862","54350","489","ATGAAACCACTTATTTCCATTATCATGGGCTCCAAATCCGACTGGAGCACTATGCAAAAAACCGCTCAAGTTTTGGATAACTTCGGCGTGGCTTATGAAAAGAAAGTCGTCTCAGCCCACCGCACACCAGACCTCATGTTCAAACATGCAGAAAAAGCCCGCAGCCGCGGCATCAAGGTCATCATTGCAGGTGCAGGCGGTGCCGCGCATTTACCGGGTATGGTGGCAGCTAAAACAACACTGCCTGTTATCGGTGTACCTGTTAAATCACGCGCCCTCAGCGGCTTGGATTCGCTCTATTCCATTGTGCAGATGCCGGGTGGTGTGCCTGTGGCAACTATGGCCATTGGTGAAGCGGGAGCGACCAACGCTGCCCTGACAGCCCTGCGTATCTTGGCCATTGAAGACCAAGACTTGGCAGCCGCGTTAGCAGATTTCGCAGAGGAACAGGGAAAAATCGCAGAGGAGTCAACGAATGAACTCAACTAA","7.80","0.71","16868","MKPLISIIMGSKSDWSTMQKTAQVLDNFGVAYEKKVVSAHRTPDLMFKHAEKARSRGIKVIIAGAGGAAHLPGMVAAKTTLPVIGVPVKSRALSGLDSLYSIVQMPGGVPVATMAIGEAGATNAALTALRILAIEDQDLAAALADFAEEQGKIAEESTNELN","54347","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0028 (purF),(purB) ; SMu0030 (purM); SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0047 (purK); SMu0054 (purB); SMu0243 (purA); SMu0321 (purR).","phosphoribosylaminoimidazole carboxylase catalytic subunit","Cytoplasm","Numerous matches in gapped BLAST to phosphoribosylaminoimidazole carboxylase sequences. Residues 1-161 are 74% similar to the enzyme from S.pneumoniae (gi15457586). Residues 3-161 are 74% similar to the enzyme from S.pyogenes (gi15674275).See Spy0033.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0044 (2e-62).","

InterPro
IPR000031
Domain

1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase
PD002193	$\"[10-130]T$	AIR_carboxyl
G3DSA:3.40.50.7700	$\"[2-157]T$	AIR_carboxyl
PF00731	$\"[3-161]T$	AIRC
TIGR01162	$\"[5-162]T$	purE
SSF52255	$\"[3-162]T$	AIR_carboxyl

noIPR
unintegrated

unintegrated
PTHR23046	$\"[1-161]T$	PTHR23046

","BeTs to 11 clades of COG0041COG name: Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase PurEFunctional Class: FThe phylogenetic pattern of COG0041 is amtkyqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000031 (1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase) with a combined E-value of 3.7e-81. IPB000031A 5-43 IPB000031B 60-102 IPB000031C 105-133 IPB000031C 103-131","Residues 5-160 are 67% similar to a (CARBOXYLASE PHOSPHORIBOSYLAMINOIMIDAZOLE) protein domain (PD002193) which is seen in Q9F1S8_STRSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 24 10:14:55 2006","Mon Jul 24 10:14:55 2006","Wed Feb 8 09:29:13 2006","Thu Mar 28 13:28:22 2002","Fri Dec 7 12:28:09 2001","Fri Dec 7 12:28:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0046 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 13:28:22 2002","Wed Feb 8 09:29:13 2006","pdb1D7AA Chain A, Crystal Structure Of E. Coli Pure-Mononucle... 137 7e-034pdb1QCZA Chain A, Crystal Structure Of E. Coli Pure, An Unusu... 137 7e-034pdb1D7AA Chain A, Crystal Structure Of E. Coli Pure-Mononucle... 157 7e-040","SMU.50","","Residues 3 to 161 (E-value = 1.1e-89) place SMu0046 in the AIRC family which is described as AIR carboxylase (PF00731)","Fri Dec 7 12:28:09 2001","24378578","","","Mathews II, Kappock TJ, Stubbe J, Ealick SE.Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.Structure Fold Des. 1999 Nov 15;7(11):1395-406.PMID: 10574791Nilsson D, Kilstrup M.Cloning and expression of the Lactococcus lactis purDEK genes, required for growth in milk.Appl Environ Microbiol. 1998 Nov;64(11):4321-7.PMID: 9797284","","Fri Dec 7 12:40:03 2001","1","","3","SMU.50","610" "SMu0047","54337","55428","1092","ATGAACTCAACTAAAACCATTGGCATAATCGGCGGCGGTCAGCTGGGTCAGATGATGGCTATCGCGGCGGTTTACATGGGGCATAAGGTGGTGACGCTGGATCCGACGGCGGACTGTCCTGCCTCGCGCGTGTCTGAGATGATTGTGGCGCCTTACGATGATGTGGATGCTTTGCGAGAAATGGCTGTGCGTTGCGACCTGCTGACCTATGAGTTTGAAAATGTCGACGCTGACGGCCTTGATGCGGTCGTAGGAGACGCTCAGCTGCCGCAGGGGACTGATTTGCTGCGCATTTCGCAAAACCGTATTTTTGAAAAGAATTTCCTCGCCAACAAGGCTGGCGTGACGGTCGCTCCATATAAGGTGGTGACCTCTAGCTTAGACTTGGAGGATTTGGATTTGGGCAAGACTTACGTCTTGAAAACGGCCACAGGCGGTTATGATGGTCACGGTCAAGTCGTTATTAAATCACACGACGATTTAGCTGCCGCGAATCAATTAGCAAACTCTGCTGAGTGCGTCTTGGAAGAGTTTGTAGACTTTGACCTTGAAATCTCGGTCATTATCTCAGGAAACGGCAAGGACGTGACAGTCTTCCCCGTTCAGGAAAATATCCACCGCAACAATATCCTCTCAAAAACCATTGTCCCAGCCCGCATTTCAGACCAGGTAGCCGAGAAGGCCAAAGCCATGGCGGTGACTATTGCCCAAAAACTCCAGCTATCAGGAACCCTCTGTGTGGAAATGTTTGCGACTGCTGACGACATCATTGTCAACGAAATCGCACCACGCCCCCACAACTCAGGCCACTACTCCATCGAAGCCTGCGACTTCTCACAATTTGACACCCATATCCTAGGCGTCCTTGGTCAGCCCCTCCCAGCCATCAAACTCCACGCCCCAGCCGTCATGCTCAACGTCCTCGGCCAGCACATTCAACAAGCTCAAGAATATGTCTCCAAAAACTCTAGCGCCCACCTCCACCTTTATGGCAAGGCAGAAGCCAAACACAACCGCAAAATGGGGCATGTGACTGTGTTTAGTGATAAGCCTGATGAAGTGAGGGAGTTTGGGGAAGGGATTGATTTTTAG","4.90","-16.09","39287","MNSTKTIGIIGGGQLGQMMAIAAVYMGHKVVTLDPTADCPASRVSEMIVAPYDDVDALREMAVRCDLLTYEFENVDADGLDAVVGDAQLPQGTDLLRISQNRIFEKNFLANKAGVTVAPYKVVTSSLDLEDLDLGKTYVLKTATGGYDGHGQVVIKSHDDLAAANQLANSAECVLEEFVDFDLEISVIISGNGKDVTVFPVQENIHRNNILSKTIVPARISDQVAEKAKAMAVTIAQKLQLSGTLCVEMFATADDIIVNEIAPRPHNSGHYSIEACDFSQFDTHILGVLGQPLPAIKLHAPAVMLNVLGQHIQQAQEYVSKNSSAHLHLYGKAEAKHNRKMGHVTVFSDKPDEVREFGEGIDF","55425","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0028 (purF),(purB) ; SMu0030 (purM); SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0054 (purB); SMu0243 (purA); SMu0321 (purR).","phosphoribosylaminoimidazole carboxylase, ATPase subunit","Cytoplasm","Several matches in gapped BLAST to Phosphoribosyl glucinamide formyltransferase sequences. Residues 1-363 are 75% similar to the enzyme from S.pneumoniae (gi15899999). Residues 1-357 are 76% similar to the enzyme from S.pyogenes (gi15674276).See Spy0034.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0045 (1e-163).","

InterPro
IPR003135
Domain

ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
PF02222	$\"[101-276]T$	ATP-grasp

InterPro
IPR005875
Domain

Phosphoribosylaminoimidazole carboxylase, ATPase subunit
TIGR01161	$\"[6-356]T$	purK

InterPro
IPR011054
Domain

Rudiment single hybrid motif
SSF51246	$\"[299-356]T$	Rudmnt_hyb_motif

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[107-289]T$	ATP_GRASP

InterPro
IPR013816
Domain

ATP-grasp fold, subdomain 2
G3DSA:3.30.470.20	$\"[156-356]T$	ATP_grasp_subdomain_2

InterPro
IPR013817
Domain

Pre-ATP-grasp fold
G3DSA:3.40.50.20	$\"[5-110]T$	Pre-ATP_grasp

noIPR
unintegrated

unintegrated
PTHR23047	$\"[60-356]T$	PTHR23047
PTHR23047:SF1	$\"[60-356]T$	PTHR23047:SF1
SSF52440	$\"[6-100]T$	SSF52440
SSF56059	$\"[101-298]T$	SSF56059

","BeTs to 7 clades of COG0026COG name: Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) PurKFunctional Class: FThe phylogenetic pattern of COG0026 is ----yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB003135 (ATP-grasp domain) with a combined E-value of 1.5e-06. IPB003135B 140-152 IPB003135C 254-264","Residues 302-353 are 51% similar to a (CARBOXYLASE PHOSPHORIBOSYLAMINOIMIDAZOLE) protein domain (PD002772) which is seen in Q9CFG5_LACLA.Residues 97-215 are 27% similar to a (CARBOXYLASE 3D-STRUCTURE SUBUNIT LYASE) protein domain (PD304326) which is seen in PURK_ECOLI.Residues 199-265 are 37% similar to a (CARBOXYLASE SUBUNIT LYASE AIRC) protein domain (PD391967) which is seen in PURK_MYCLE.Residues 25-73 are 64% similar to a (CARBOXYLASE PHOSPHORIBOSYLAMINOIMIDAZOLE) protein domain (PD004980) which is seen in Q9CFG5_LACLA.Residues 98-265 are 57% similar to a (LIGASE SYNTHETASE CARBOXYLASE COMPLETE PROTEOME) protein domain (PD000180) which is seen in Q9CFG5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 8 09:35:04 2006","Fri Dec 7 12:43:11 2001","Wed Feb 8 09:35:04 2006","Thu Mar 28 13:29:12 2002","Fri Dec 7 12:43:11 2001","Fri Dec 7 12:43:11 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0047 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 13:29:12 2002","Wed Feb 8 09:35:04 2006","pdb1B6SB Chain B, Structure Of N5-Carboxyaminoimidazole Ribon... 127 2e-030pdb1B6RA Chain A, N5-Carboxyaminoimidazole Ribonucleotide Syn... 127 2e-030pdb1EYZA Chain A, Structure Of Escherichia Coli Purt-Encoded ... 84 3e-017","SMU.51","","Residues 33 to 190 (E-value = 7.7e-14) place SMu0047 in the ATP-grasp family which is described as ATP-grasp domain (PF02222)","Fri Dec 7 12:43:11 2001","24378579","","","Nilsson D, Kilstrup M.Cloning and expression of the Lactococcus lactis purDEK genes, required for growth in milk.Appl Environ Microbiol. 1998 Nov;64(11):4321-7.PMID: 9797284Thoden JB, Firestine S, Nixon A, Benkovic SJ, Holden HM.Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.Biochemistry. 2000 Aug 1;39(30):8791-802.PMID: 10913290","","Fri Dec 7 12:52:06 2001","1","","3","SMU.51","222" "SMu0048","55428","56093","666","GTGGATAAGTTTTTTACAAATGAACACGGTTATTTTAATTGGCAATCTGTATTAGCGATTGTAGGGATTCTTGGCTTTTTATGGGGGATTTATATCTATGTTGATAAACGAAAATCGAAGATACAAGAACGAAAAATACAAAGTCAAGTACAAAAACAAGAAAAATTAACGGAACCTTATAACGAGTTAATCAGGATAATATCTTTATTTCCAAATAGAACTCCATATGATGTCATGACTCTATTATCATATGGACCACCTAACTTTAGTTCAGAAAACTTTGATACGGTGAATAGAATTTTGGAAATTCAGATTAAGGAAGATTATCAAAAGCGATTAGAGCGAAAAGGTCTTACTTATCAAGATGAAGAAGATATCAAAACAGAAATTCGGAATAGAGAATACTATATAAAGGAAATAGAAAAAATCAAAAATCAGTATTTTCTAGCTAAGCAAGAGTATGAGCGATTTAGACATACTGATAAAACTATTGAACTGTATGCAGGCCAAGATGTAAAAAATTGCTTAGTAGAGTTTTATGTTACTTGGCATAATGCTTTTATAGCAGGGAGAACCTTGGAATATGCTGATGGAAGACAAAATAAACTGGATAATATTCGTTGGAAACTTGAACAAGTCATAAGGGCTGACCTAGGTATTATTTAA","8.40","1.69","26613","MDKFFTNEHGYFNWQSVLAIVGILGFLWGIYIYVDKRKSKIQERKIQSQVQKQEKLTEPYNELIRIISLFPNRTPYDVMTLLSYGPPNFSSENFDTVNRILEIQIKEDYQKRLERKGLTYQDEEDIKTEIRNREYYIKEIEKIKNQYFLAKQEYERFRHTDKTIELYAGQDVKNCLVEFYVTWHNAFIAGRTLEYADGRQNKLDNIRWKLEQVIRADLGII","56090","","conserved hypothetical protein","Cytoplasm","Single significant match in gapped BLAST to gi|16802129 from Listeria monocytogenes. Residues 37-220 are 38% similar to residues 16-199 of this protein.SMu0048 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[14-34]?$	transmembrane_regions

InterPro
IPR001920
Family

Asp/Glu racemase
PF01177	$\"[3-228]T$	Asp_Glu_race
PS00923	$\"[79-88]?$	ASP_GLU_RACEMASE_1
PS00924	$\"[192-202]?$	ASP_GLU_RACEMASE_2
SSF53681	$\"[1-116]T$ $\"[117-230]T$	Asp/Glu_race

InterPro
IPR004380
Family

Aspartate racemase
TIGR00035	$\"[1-230]T$	asp_race

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1860	$\"[106-230]T$	G3DSA:3.40.50.1860

","BeTs to 4 clades of COG1794COG name: Aspartate racemaseFunctional Class: MThe phylogenetic pattern of COG1794 is a--K----eb-----------Number of proteins in this genome belonging to this COG is 1","***** IPB001920 (Aspartate and glutamate racemases) with a combined E-value of 8.9e-27. IPB001920A 3-34 IPB001920B 76-106 IPB001920C 120-131 IPB001920D 190-206 IPB001920A 23-54","Residues 26-165 are 53% similar to a (RACEMASE ASPARTATE PROTEOME COMPLETE) protein domain (PD355676) which is seen in Q9PJ41_CAMJE.Residues 173-226 are 62% similar to a (RACEMASE ASPARTATE PROTEOME COMPLETE) protein domain (PD086949) which is seen in Q9CKJ1_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 15:18:44 2002","Mon Oct 7 15:22:31 2002","Tue Oct 22 15:18:44 2002","Tue Oct 22 15:18:44 2002","Fri Dec 7 13:01:43 2001","Fri Dec 7 13:01:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0050 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:22:31 2002","","No significant hits to the NCBI PDB database.","SMU.54","","Residues 3 to 228 (E-value = 3.3e-65) place SMu0050 in the Asp_Glu_race family which is described as Asp/Glu/Hydantoin racemase (PF01177)","Fri Dec 7 13:01:43 2001","24378582","","","Glavas S, Tanner ME.Active site residues of glutamate racemase.Biochemistry. 2001 May 29;40(21):6199-204.PMID: 11371180 Nishizawa T, Asayama M, Shirai M.Cyclic heptapeptide microcystin biosynthesis requires the glutamate racemase gene.Microbiology. 2001 May;147(Pt 5):1235-41.PMID: 11320126","","Fri Dec 7 13:08:52 2001","1","","3","SMU.54","" "SMu0051","57125","57388","264","ATGATGGAAGAATTCGATGATGTATTTGAAGATGATATTACCACTCTGACATTTACCTATGCGGATGAAGTAGTCATTCCAGAAATTCCGGATGCAGAAGGTATTCATATTGTAGAGATAACAAACAATCGACTGGTTATAGAGCATACGCGCGATGATGACGAGGTCTATGAATATATAGAGAGCTGTGGATTAACAAGTCGCCCCATAAAACTTTCGATTGAATTTTGTGTTTACGAAGATCCTGAGGAAGAAAATTTTTAG","3.60","-21.61","10180","MMEEFDDVFEDDITTLTFTYADEVVIPEIPDAEGIHIVEITNNRLVIEHTRDDDEVYEYIESCGLTSRPIKLSIEFCVYEDPEEENF","57385","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0051 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:23:15 2002","Fri Dec 7 13:11:15 2001","Mon Oct 7 15:23:15 2002","Fri Dec 7 13:11:15 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0051 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:23:15 2002","","No significant hits to the NCBI PDB database.","SMU.55","","No significant hits to the Pfam 11.0 database","Fri Dec 7 13:11:15 2001","24378583","","","","","","1","","3","SMU.55","" "SMu0052","57408","57536","129","ATGATTCAAATCATTGTCAATGCTTTTGTTGAGAAGGATAAGACTGGAGCAGTTATAGAAGTTTTGTATGCTAGTAACAATCACGAAAAGGTGAAAGCTAAGTATGAAGAGCTAGTTGCAATATCATGA","5.80","-0.78","4689","MIQIIVNAFVEKDKTGAVIEVLYASNNHEKVKAKYEELVAIS","57533","","Streptococcus-specific protein","Cytoplasm","Single weak match in gapped BLAST to gi|15902099, a hypothetical of S.pneumoniae.SMu0052 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:16:07 2002","Fri Dec 7 13:13:11 2001","Thu Oct 24 14:16:07 2002","Fri Dec 7 13:13:11 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0052 is 69% similar to residues 1-39 of SMu0049, also a hypothetical.SMu0052 is paralogously related (blast p-value < 1e-3) to SMu0049.","Mon Oct 7 15:24:08 2002","","No significant hits to the NCBI PDB database.","SMU.56","","No significant hits to the Pfam 11.0 database","Fri Dec 7 13:13:11 2001","24378584","","","","","","1","","3","SMU.56","" "SMu0053","57639","58934","1296","ATGGATTATATTACTTTTAAAACAAAGCTGTTTGAATATTTGAACGTTCAGAATGATACACCCGATGATAAAATATACTTCAAAGTAGAAAATTCGAGATATAAAGATGATGAATTATTGGTGTTTGATAATGAAGAAATAGAAAAATTGTTTTTATTATTATCTGACTATAAGCAGGAAGAAAATTATTTTTTAGAGTCTAGTACTAGTTTTGAACTGTTTTTGACATCAAGTAATGTAGGAATTCCTTTTAGATTTTACTATCCTTCTATAGAATTAGAGGATAATACTTCTAATATAAATTATTATATATCTGAAATCTCTGATGCCTCAACACTTTATTTACTATATAAGCGAATTGAGGAAATGGTTGATTCTGATCATGATATACTTATGTATTTTAAAGATATGGATTTTCGTAAGAGAAGATTTGGAAGACTTGAACAAGTAGAGTTTGAACAAGATAAGAGCTATGAATCTTTCTTGAGGTACATATCCAATCGGATTATTCCCTATAATTCCTCATTGAAAATTGTTTCTAACGAACCTAAGACTATAGATGAGTTCAAACGATATAAAGATTCTTTTATTTTCACTTATATTTATGGTAAGCATAGACCAATAATTGAAGCTGAAAATTTGAATAAAATCAGTGATGAGAAAAGGTTGTATGGGGCAAAACCTTTTGAAATGGAAGCGCCAAAAAGGAGATACGATCCTTTTATAATTGAATACTACCGACAAGCTTCGGAAAGTAGCGATCCATTTATACAATTTATTTCTTATTATCATATCCTAGAATATTTTTATGATGAAATATTTAATAAAAAATTAATAGATGATTTGATGAACAAAATAACTCATCCTGATTTTTCCTATAGGAATAAATCTAAAATCAAGGAGTTGGCTTATTTTTCTCATAAACGATTGACTGGCTTTGGTGAGGATGGTCAAGGTAATGAGTTAGAATCCTTAAAATTTGTTTTAAAAGAGTATGTCAGACCTATAGAATTAAAAGAAAGACTAATAGAGTTGAAACAAGATCCAGACTATTATCAAAATAATAAAGTAGATTTTAGTAATGGCCCCGGTATTTCTTTTAGTGACGAAGAGGGGATATATATTGCTCTTGCAAAAAGGATTTATTTTACTAGAAATTCCTTGATTCACAGTAAGAGTAATAGGAAATCTCAGACTTATCGAGTGAATATTCATAAAGATATTTTAAGAAATGAGATTCCATTATTGGAAGCAGTGTCGGAATTAGTAATATTGAATTCTTCTGAAATTTTATAA","5.00","-13.25","51775","MDYITFKTKLFEYLNVQNDTPDDKIYFKVENSRYKDDELLVFDNEEIEKLFLLLSDYKQEENYFLESSTSFELFLTSSNVGIPFRFYYPSIELEDNTSNINYYISEISDASTLYLLYKRIEEMVDSDHDILMYFKDMDFRKRRFGRLEQVEFEQDKSYESFLRYISNRIIPYNSSLKIVSNEPKTIDEFKRYKDSFIFTYIYGKHRPIIEAENLNKISDEKRLYGAKPFEMEAPKRRYDPFIIEYYRQASESSDPFIQFISYYHILEYFYDEIFNKKLIDDLMNKITHPDFSYRNKSKIKELAYFSHKRLTGFGEDGQGNELESLKFVLKEYVRPIELKERLIELKQDPDYYQNNKVDFSNGPGISFSDEEGIYIALAKRIYFTRNSLIHSKSNRKSQTYRVNIHKDILRNEIPLLEAVSELVILNSSEIL","58931","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0053 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:24:58 2002","Fri Dec 7 13:17:23 2001","Mon Oct 7 15:24:58 2002","Fri Dec 7 13:17:23 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0053 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:24:58 2002","","No significant hits to the NCBI PDB database.","SMU.58","","No significant hits to the Pfam 11.0 database","Fri Dec 7 13:17:23 2001","24378585","","","","","","1","","3","SMU.58","" "SMu0054","59244","60542","1299","ATGATCAACCGTTATTCACGCCCTGAGATGGCGAACATTTGGAGTGAAGAAAACAAGTACCGTGCTTGGTTGGAAGTGGAAATTTTGGCTGACGAGGCTTGGGCTGAGTTGGGTGAGATTCCTAAGGAAGATGTGGCCAAGATTCGCGAGAAGGCGGATTTTGATATTGACCGCATTTTGGAGATTGAGCAGCAAACGCGTCACGATGTGGTAGCCTTTACCCGTGCGGTTTCTGAGACGTTGGGTGAGGAGCGCAAGTGGGTACACTTTGGGCTGACCTCAACAGACGTGGTGGACACGGCCTACGGCTACCTATACAAGCAGGCTAACGCCATCATTCGTAAGGACTTGGATAATTTCCTCAGTATCATCGCTGATAAGGCCAAAGAACACAAGTTTACCATCATGATGGGGCGCACGCACGGTGTCCATGCGGAGCCAACAACTTTTGGTCTCAAGCTGGCGACTTGGTACAGTGAAATGAAGCGTAATATTGAGCGTTTTGAACATGCTGCCGCTGGTGTGGAAGCTGGGAAAATCTCTGGTGCTGTTGGGAACTTTGCCAACATTCCGCCCTTTGTGGAAAAATATGTCTGTGACAAATTAGGCATTCGTGCTCAGGAAATTTCAACTCAAGTCTTACCGCGTGATTTGCATGCTGAATATTTTGCCGTGCTAGCCAGCATTGCCACATCAATCGAGCGCATGGCGACTGAAATCCGTGGTCTGCAAAAATCCGAACAGCGTGAAGTAGAAGAGTTCTTTGCCAAGGGGCAAAAAGGCAGCTCTGCTATGCCCCATAAACGCAACCCTATCGGCTCTGAAAATATGACGGGGCTTGCGCGTGTGATTCGCGGACACATGGTGACGGCCTATGAAAATGTGTCCCTCTGGCACGAACGCGATATTTCCCACTCATCAGCTGAGCGCATTATCGCGCCTGATACGACCATTCTCATTGACTACATGCTCAATCGCTTTGGCAATATCGTGAAAAACTTGACCGTCTTCCCAGAAAATATGAAGCGCAACATGGGCTCTACCTTTGGTCTCATTTTCAGCCAGCGTGCTATGCTGACCTTAATTGAAAAAGGCATGACCCGCGAGCAGGCTTACGACCTTGTTCAGCCTAAGACTGCGCAGTCTTGGGACAACCAAGTGGACTTCAAACCGTTGCTGGAAGCAGATCCAGAGATCACGTCTCGCTTGAGCCAAGAAGAAATCGACGAAATCTTTAATCCAGTCTACTACACCAAGCGTGTGGATGAAATCTTTGACCGGATTGGATTGGGAGACTAA","5.50","-10.34","49366","MINRYSRPEMANIWSEENKYRAWLEVEILADEAWAELGEIPKEDVAKIREKADFDIDRILEIEQQTRHDVVAFTRAVSETLGEERKWVHFGLTSTDVVDTAYGYLYKQANAIIRKDLDNFLSIIADKAKEHKFTIMMGRTHGVHAEPTTFGLKLATWYSEMKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEKYVCDKLGIRAQEISTQVLPRDLHAEYFAVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMVTAYENVSLWHERDISHSSAERIIAPDTTILIDYMLNRFGNIVKNLTVFPENMKRNMGSTFGLIFSQRAMLTLIEKGMTREQAYDLVQPKTAQSWDNQVDFKPLLEADPEITSRLSQEEIDEIFNPVYYTKRVDEIFDRIGLGD","60539","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0028 (purF),(purB) ; SMu0030 (purM); SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0243 (purA); SMu0321 (purR).","adenylosuccinate lyase","Cytoplasm, Extracellular","This sequence corresponds to the previously sequenced gi1661185 and gi2492946 in GenBank, predicted adenylosuccinate lyase sequences.Several matches in gapped BLAST to adenylosuccinate lyase sequences. Residues 1-430 are 91% similar to the enzyme from S.pyogenes (gi15674278).See Spy0036.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0047 (0.0).","

InterPro
IPR000362
Domain

Fumarate lyase
PR00149	$\"[88-106]T$ $\"[133-149]T$ $\"[216-243]T$ $\"[261-277]T$	FUMRATELYASE
PF00206	$\"[3-286]T$	Lyase_1
PS00163	$\"[261-270]T$	FUMARATE_LYASES

InterPro
IPR003031
Domain

Delta crystallin
PR00145	$\"[128-148]T$ $\"[216-240]T$ $\"[261-277]T$	DCRYSTALLIN

InterPro
IPR004769
Family

Adenylosuccinate lyase
TIGR00928	$\"[1-429]T$	purB

InterPro
IPR008948
Domain

L-Aspartase-like
SSF48557	$\"[2-428]T$	L-Aspartase-like

noIPR
unintegrated

unintegrated
G3DSA:1.20.200.10	$\"[91-419]T$	G3DSA:1.20.200.10
PTHR11444	$\"[1-429]T$	PTHR11444
PTHR11444:SF2	$\"[1-429]T$	PTHR11444:SF2

","BeTs to 12 clades of COG0015COG name: Adenylosuccinate lyaseFunctional Class: FThe phylogenetic pattern of COG0015 is amtkyqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000362 (Fumarate lyase) with a combined E-value of 1.3e-15. IPB000362A 138-151 IPB000362B 261-271","Residues 10-151 are 79% similar to a (LYASE ADENYLOSUCCINATE ASL BIOSYNTHESIS) protein domain (PD408312) which is seen in Q9KF61_BACHD.Residues 154-427 are 82% similar to a (LYASE ADENYLOSUCCINATE BIOSYNTHESIS) protein domain (PD328331) which is seen in Q9CF40_LACLA.Residues 1-84 are 80% similar to a (LYASE ADENYLOSUCCINATE BIOSYNTHESIS) protein domain (PD403086) which is seen in Q9CF40_LACLA.Residues 86-153 are 80% similar to a (LYASE ARGININOSUCCINATE BIOSYNTHESIS) protein domain (PD403746) which is seen in Q9CF40_LACLA.Residues 25-151 are 33% similar to a (LYASE ADENYLOSUCCINATE COMPLETE PROTEOME) protein domain (PD245535) which is seen in Q9CJY7_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 8 10:12:39 2006","Fri Dec 7 13:18:43 2001","Wed Feb 8 10:12:39 2006","Thu Mar 28 13:30:24 2002","Fri Dec 7 13:18:43 2001","Fri Dec 7 13:18:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0054 is paralogous to SMu0301, a predicted arginosuccinate lyase. Residues 36-375 are 23% similar to SMu0301. SMu0054 is paralogously related (blast p-value < 1e-3) to SMu0301.","Wed Jan 9 14:26:49 2002","Wed Feb 8 10:12:39 2006","pdb1F1OA Chain A, Structural Studies Of Adenylosuccinate Lyases 657 0.0pdb1C3UA Chain A, T. Maritima Adenylosuccinate Lyase >gi7245... 442 5e-125pdb1C3CA Chain A, T. Maritima Adenylosuccinate Lyase >gi7245... 440 2e-124","SMU.59","","Residues 3 to 286 (E-value = 5.8e-92) place SMu0054 in the Lyase_1 family which is described as Lyase (PF00206)","Fri Dec 7 13:18:43 2001","24378586","","","Brosius JL, Colman RF.A key role in catalysis for His89 of adenylosuccinate lyase of Bacillus subtilis.Biochemistry. 2000 Nov 7;39(44):13336-43.PMID: 11063569 Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO.The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.J Mol Biol. 2000 Aug 11;301(2):433-50.PMID: 10926519 Toth EA, Yeates TO.The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway.Structure Fold Des. 2000 Feb 15;8(2):163-74.PMID: 10673438 ","","Fri Dec 7 13:26:41 2001","1","","3","SMU.59","9" "SMu0055","60562","61248","687","ATGGGCTGCCTTTTATGCTATAATCAAGCTATGGACAAGAAAACACTTATTCAAACTTTTTATGATCATGCAGACCAAGAGCGGGCGCATGCTATGGCAGCCTATATGCGTGACCAGTTTCCTTTTCTAGGTCTTTCCACTCCGCTTCGCCGTCAGTTGGAGAAGGACTTTGTTAAAGAATCTAAGGCGTCTAAGGCGGTTGATTGGGTTTTTGTGGAAGAGTTGTGGGAACTGCCTGAGCGGGAATTTCAGTACGCTGCTTGTGATTATTTACGGGCTATGCAGATCTTTTTAACGGAAGCAGATCTGCCTCGTCTCAAACAGCTGGTTGTAACCAAGTCTTGGTGGGATACAACGGACAGTTTGGACAGAACCATTGGTAAGATCAACTTTCCCAGTAGTATCGTTGATGCAACTATGTTAGAGTGGTCCTCTGATGATAACTTTTGGCTGCGGCGCGTGGCAATTGACCACCAGCTTTTACGAAAAGATAAGATGAAGACAAATCTTTTGGAGAAGATTCTCATTAACAATCTCAATCAAAGCGAATTTTTCATCAATAAAGCTATTGGCTGGATCTTGCGAGACTACTCTAAGACTAATCCAGATTGGGTTAGAACTTTTATTGAAAAGCATAAAAATCAGATGGCCAATTTATCGATTAAAGAAGCTAGCAAATATTTATGA","7.40","0.83","26989","MGCLLCYNQAMDKKTLIQTFYDHADQERAHAMAAYMRDQFPFLGLSTPLRRQLEKDFVKESKASKAVDWVFVEELWELPEREFQYAACDYLRAMQIFLTEADLPRLKQLVVTKSWWDTTDSLDRTIGKINFPSSIVDATMLEWSSDDNFWLRRVAIDHQLLRKDKMKTNLLEKILINNLNQSEFFINKAIGWILRDYSKTNPDWVRTFIEKHKNQMANLSIKEASKYL","61245","","DNA alkylation repair enzyme","Cytoplasm","Several matches in gapped BLAST to DNA alkylation repair enzyme sequences. Residues 14-228 are 42% similar to the enzyme from B.cereus (gi4584089). Residues 141-228 are 65% similar to residues 3-90 of the enzyme from S.pneumoniae (gi15902391). Residues 11-56 are 39% similar to residues 1-46 of what appears to be a truncated enzyme in S.pneumoniae (gi15902389).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1132 (2e-44).","

InterPro
IPR014825
Family

DNA alkylation repair enzyme
PF08713	$\"[24-228]T$	DNA_alkylation

noIPR
unintegrated

unintegrated
SSF48371	$\"[11-203]T$	SSF48371

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 27-104 are 46% similar to a (ENZYME REPAIR DNA ALKYLATION) protein domain (PD354754) which is seen in Q9XBL3_BACCE.Residues 16-72 are 43% similar to a (PROTEOME COMPLETE) protein domain (PD389673) which is seen in Q9CDS8_LACLA.Residues 106-228 are 42% similar to a (PROTEOME COMPLETE ENZYME REPAIR) protein domain (PD291086) which is seen in Q9CDS9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:25:53 2002","Fri Dec 7 13:48:47 2001","Thu Sep 14 10:14:07 2006","Fri Dec 7 13:48:47 2001","","Fri Dec 7 13:48:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0055 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:33:07 2002","","No significant hits to the NCBI PDB database.","SMU.60","","No significant hits to the Pfam 11.0 database","Fri Dec 7 13:48:47 2001","24378587","","","","","","1","","3","SMU.60","933" "SMu0056","61631","62545","915","ATGTTAAAAGATTTTGGGAAGAAAATTAAGAGCCTGAGGTTAGAAAAGGGGCTGACCAAAGAAGCTGTCTGCCTTGATGAATCTCAATTGTCAACACGGCAGTTGACCAGAATTGAATCAGGACAGTCTACGCCAACTCTTAATAAAGCTGTTTATATTGCAGGACGTTTAGGAGTGACGCTTGGCTATTTAACGGACGGAGAAAATGTTGAGTTACCCAGTCGTTATAAAGAACTAAAGTATTTATTATTACGAACGCCAACCTATGGCGACCAACAAAGATTAGCTGAAAAAGAAACCTATTTTGACGAGATTTTTAGTCAGTTTTATGATGATTTGCCTGAAGAAGAACAATTGATTATTGATGGCTTACAATCGAAACTAGATATTCATTTTAGTGACAATATCGATTTTGGCGTTGGTATTTTAAATGACTATTTTGATCAGATTTTAAGAAAAACCAATTATCAGGTCAATGATTTGATTCTGATTGATCTCTATTTTTCCTGCTTAACTGTTAGTGGTTTGGATTCAGCTATTTTTGATTCAAGAAAATATAATCAATTATTGGAGACATTGCTTAAGCAGGTAGACTGCCTTCCATTGGAAGATCTTTTCGTTTTAAATAATGTTTTATTGAATAATTTTGGACTCCTCTTAGAATTGAAAAAATATGATTTTGTTAAGCAGCTTATTGCTGTCAGCAATAAAATCATGGATAGAACTCATGATTTTCAAAAAAAGCCTATTGTTAATCTTCTGACATGGAAGCATCATTTATTTGTTGAAAAAGATTATGCGGAAGCTAAAAAGAGCTATGATGCTGCTATCTTATTTGCCCAGTTAACAGAAAACATTAATTTAAGAGAAAATTTGGAGAAAGAATGGCAAAAAGATTCTCAGAACGGGACATAA","4.90","-9.16","35233","MLKDFGKKIKSLRLEKGLTKEAVCLDESQLSTRQLTRIESGQSTPTLNKAVYIAGRLGVTLGYLTDGENVELPSRYKELKYLLLRTPTYGDQQRLAEKETYFDEIFSQFYDDLPEEEQLIIDGLQSKLDIHFSDNIDFGVGILNDYFDQILRKTNYQVNDLILIDLYFSCLTVSGLDSAIFDSRKYNQLLETLLKQVDCLPLEDLFVLNNVLLNNFGLLLELKKYDFVKQLIAVSNKIMDRTHDFQKKPIVNLLTWKHHLFVEKDYAEAKKSYDAAILFAQLTENINLRENLEKEWQKDSQNGT","62542","","transcriptional regulator, Cro/CI family","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and transcriptional regulators. Residues 1-299 are 44% similar to gi15674279, a hypothetical from S.pyogenes. Residues 6-299 are 36% similar to a predicted regulator from S.pneumoniae (gi15903845).See Spy0037.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0048 (8e-67).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[9-64]T$	HTH_3
SM00530	$\"[8-64]T$	HTH_XRE
PS50943	$\"[9-64]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[5-71]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[5-73]T$	G3DSA:1.10.260.40

","BeTs to 3 clades of COG1396COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1396 is --T--qV-EBR---------xNumber of proteins in this genome belonging to this COG is 6","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:27:20 2002","Thu Sep 28 09:05:37 2006","Wed Feb 8 10:19:15 2006","Wed Feb 8 10:19:15 2006","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0056 is paralogous to SMu0344, a conserved hypothetical. Residues 3-299 are 31% similar to SMu0344.SMu0056 is paralogously related (blast p-value < 1e-3) to SMu0344, SMu0197, and SMu0737.","Mon Oct 7 15:36:10 2002","","No significant hits to the NCBI PDB database.","SMU.61","","Residues 9 to 64 (E-value = 6.7e-07) place SMu0056 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Fri Dec 7 14:04:22 2001","24378588","","","","","","1","","","SMU.61","" "SMu0057","64920","63079","1842","ATGAGTAAAAAATTTCTTTTTAATCGCTCTGTTTTCTCAAATGCTAAGGGACATGATGTCAAACGTAAATCCTCCAAAGGTCTCGTAACAGGTATTGCCTTAGCAGGAGCTATTGTTTTACTTGGAGGCAGCCAAATTGCTTCTGCTGATAACGTTACTGCTTCAGAAAACAACACAACCACATCCTCAACTGCAGCTGACACAGACACTGCAAACTCTCAGACAGTTGACAGCACTGATAGTGACAACAGCCAAGTTACTTCTGAGACTGTCTCATCAAAAAATAGCACAGCAAGCAGTGAGGCTGCTTCTGAAAGCAATGAAGCTGAGACAAACAATGACGCAACAGCTTCTGAGTCAGCCGATCAAAGTGATGATGAACTTTCCGATGAAACAACAAGTAATGAAGCTCAAGTTAAGTCTCAATCAGTCAATGCTTTAGAATCAGCAAAATATGATAAAGATGATGATGAAGAGGAAGAAGAAGTCAACGAATACAAAGAAGATGACAAATCTGAAAAAGCAGATATTAAATTTGACAACACAGGCGTAAAAACAACTTCATCTGGTGTGAACATTGATGGAAAAAACATTACCATTACATCAGCAGGAACTTATACCATTACAGGGTCTGCCAGCGGCTACAGCATATCAGTAGCAGATAAAGTGACTGATACAGTGAAGCTCAAACTCGATGCAGTGAATTTGACTGACTCCACTCTTTATTCATCAAGAGATTTAGATATTAAAGTCCTATCTGATAGCTCTATTTCGTCTTCTTTGAAGAATACAATCGAAACAGGAGGAGCACTCTACATTTCAAGTAAAAAGAAAAGCGGTTTGAAAGTCACAAGTACAGCTGGTCACGCTATCAAAGCAAACAGTTTAGAAGCTGATAAAGTAACCTTAGAGCTGTCTTCTACTGCTAAAGATGGGATTAATGCCACATCAAACGTCTCCATTAAAAAGTCAAATGTTACCATTTCGGCAGAAGATGATGGGATTCAAGCTGAAGATAATACCGATGTCAATTCAGGTGATATCCAGATCAAAGATTCTATTGTAAAAATCACCTCTACAAGTAAAGGAATTACAGCGAACGACGAGATAACCGTTAAAGGGTCAACTTTCATAACAATTACATCTGGCTCTGAAGGAATCGAAGGCCGCTATGTGAATTTGAAAAAAGGTCAAATAACGATCAATGCTGGTGATGATGCTATCAACGCGACTGAATGGACAACAAAAGACGATGCTGACCTATCGCATTTGAAAAACAGTAAGAAAGATATCGAAAATGAGGTTGCTATTGTTATTTCTGGTGCTAATATCAGCGGTATTGGCAAAGATGACGGTGTGGATTCAAATGGAAATCTCTATATTACCGATGGTAGTCTCAAAATTCAATCAATCACTGATTACAGCTCAGCCATTGATTATGATGGTACAGGGTTTGCTTCCGGAGGAACAACTTGGGCAATTGGCCATATGGGATTTGCTCAGGGCTTCTCAAAGGGAACCAAACAAGCTTATATTGCTGCGATTGTTTCAGGATTAGCCGGTGATACCATTACTATAACTGACTCAAAAGGACATATCGTTGCAAAAACAAAGGCAGATGTAGACTTTGACCATGTTGTCTTTTCAAATAAAACCATCAAGGCAGGCAAAACCTACACGGTTACAACATCTGATGGTCATAAAGCAGTTATCAAAGCAACAAAAGACACAACCACTCATCCTTCAGGCAGGCATGTATCAAAAGATACCGTTCCGCTCCTTCCAAATGGCCATCATCCAGCCTTTCCTGGAAACGGAACCCCTCCAAATGATAAGAACTGA","4.60","-26.29","63954","MSKKFLFNRSVFSNAKGHDVKRKSSKGLVTGIALAGAIVLLGGSQIASADNVTASENNTTTSSTAADTDTANSQTVDSTDSDNSQVTSETVSSKNSTASSEAASESNEAETNNDATASESADQSDDELSDETTSNEAQVKSQSVNALESAKYDKDDDEEEEEVNEYKEDDKSEKADIKFDNTGVKTTSSGVNIDGKNITITSAGTYTITGSASGYSISVADKVTDTVKLKLDAVNLTDSTLYSSRDLDIKVLSDSSISSSLKNTIETGGALYISSKKKSGLKVTSTAGHAIKANSLEADKVTLELSSTAKDGINATSNVSIKKSNVTISAEDDGIQAEDNTDVNSGDIQIKDSIVKITSTSKGITANDEITVKGSTFITITSGSEGIEGRYVNLKKGQITINAGDDAINATEWTTKDDADLSHLKNSKKDIENEVAIVISGANISGIGKDDGVDSNGNLYITDGSLKIQSITDYSSAIDYDGTGFASGGTTWAIGHMGFAQGFSKGTKQAYIAAIVSGLAGDTITITDSKGHIVAKTKADVDFDHVVFSNKTIKAGKTYTVTTSDGHKAVIKATKDTTTHPSGRHVSKDTVPLLPNGHHPAFPGNGTPPNDKN","63082","","conserved hypothetical protein","Extracellular, Cellwall","Weak similarities in gapped BLAST to platelet binding proteins and conserved hypotheticals, posible lipoproteins. Residues 78-582 are 14% similar to residues 1926-2436 of S.gordonii (gi|15991793).SMu0057 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR013256
Family

Chromatin SPT2
SM00784	$\"[94-176]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[28-48]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 78-377 are 16% similar to a (STREPTOCOCCAL HEMAGGLUTININ) protein domain (PD327862) which is seen in Q9KWR3_STRGN.Residues 181-591 are 19% similar to a (PROTEOME LIPOPROTEIN COMPLETE POSSIBLE) protein domain (PD327278) which is seen in Q9PHN8_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 14:34:06 2002","Fri Dec 7 14:25:14 2001","Fri Dec 7 14:27:13 2001","Fri Dec 7 14:25:14 2001","","Fri Dec 7 14:25:14 2001","yes","Fri Feb 20 15:41:32 MST 1998","No definite paralogs in S.mutans but very weak similarities to SMu0914, SMu0700, SMu0999 and others, an assortment of glycosyltransferases and hypotheticals.SMu0057 is paralogously related (blast p-value < 1e-3) to SMu0914, SMu0700, SMu0999, SMu1729, SMu0630, SMu1947, SMu1843, SMu0897, SMu0827, SMu1273, SMu0764, and SMu0556.","Wed Jan 9 14:34:06 2002","","No significant hits to the NCBI PDB database.","SMU.63c","","No significant hits to the Pfam 11.0 database","Fri Dec 7 14:25:14 2001","24378589","","","","","","1","","","SMU.63c","" "SMu0058","65217","66251","1035","GTGCTATTCTGCTTACTTCGTTTCTGTTATAATAGTCTTATGACTAGAATTTTAGATAACGAACTTATGGGTGATGAGGAATTTGCAGAACGCACACTTCGTCCGCAGTATTTACAGGAATATATTGGTCAGGATAAGGTTAAAGACCAGCTGAAGATCTTCATCAAAGCAGCTAAACAACGTGATGAGGCTTTGGATCATGTCCTTTTATTTGGTCCTCCTGGCCTTGGTAAGACCACCATGGCTTTTGTTATTGCCAATGAATTGGGGGTTAATCTTAAGCAAACCAGCGGTCCAGCTATTGAAAAAGCTGGTGATTTGGTTGCTGTTTTAAATGATTTAGAGCCTGGGGATGTTCTTTTTATTGATGAAATTCATCGGCTGCCTATGGCTGTTGAGGAAGTTCTTTATAGTGCCATGGAAGATTTTTATATTGACATTATGATTGGTGCAGGAGAAACTTCTCGCAGCGTGCATTTGGATTTGCCGCCTTTTACTTTAATTGGGGCGACAACACGGGCAGGTATGTTGTCAAATCCTTTGCGTGCGCGTTTTGGGATTACAGGTCATATGGAATATTATACAGATATCGATTTAACTGAAATTGTTGAGCGAACAGCGGATATTTTTGAGATGACCATTACCCATCAAGCTGCGTTAGAATTAGCACGGCGTTCCCGTGGGACTCCGCGTATTGCTAACCGACTCTTAAAACGTGTCCGAGATTATGCCCAAATTATGGGAGATGGTCTTATTGATGATAAAATAACAGATAAAGCTTTGACCATGCTTGATGTTGATCATGAAGGCCTTGATTATGTTGATCAGAAGATCCTTAAGACGATGATTGAGATGTACCATGGCGGGCCTGTTGGTCTGGGGACTCTGTCAGTTAATATTGCCGAGGAACGTGAGACCGTTGAAGACATGTATGAGCCCTATCTTATTCAAAAAGGATTTATCATACGGACTCGCAGTGGACGTGTAGCCACTGCCAAAGCTTATGAACATTTGGGTTATCGTTACACAGAATAA","4.90","-14.13","38848","MLFCLLRFCYNSLMTRILDNELMGDEEFAERTLRPQYLQEYIGQDKVKDQLKIFIKAAKQRDEALDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAIEKAGDLVAVLNDLEPGDVLFIDEIHRLPMAVEEVLYSAMEDFYIDIMIGAGETSRSVHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYTDIDLTEIVERTADIFEMTITHQAALELARRSRGTPRIANRLLKRVRDYAQIMGDGLIDDKITDKALTMLDVDHEGLDYVDQKILKTMIEMYHGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIIRTRSGRVATAKAYEHLGYRYTE","66248","For other 'ruv' genes see SMu1895 (ruvA).","Holliday junction DNA helicase","Cytoplasm","Several matches in gapped BLAST to RuvB helicases. Residues 14-344 are 91% similar to the enzyme from S.pneumoniae (gi15900193).This sequence is similar to Spy0038.This sequence is weakly similar to gi4098493, a hypothetical previously published in GenBank. Residues 65-151 are 35% similar to residues 7-93 of gi4098493.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0049 (1e-173).","

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[64-198]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[67-246]T$	AAA

InterPro
IPR004605
Family

Holliday junction DNA helicase RuvB
TIGR00635	$\"[36-340]T$	ruvB: Holliday junction DNA helicase RuvB

InterPro
IPR008823
Domain

Holliday junction DNA helicase RuvB, C-terminal
PF05491	$\"[263-341]T$	RuvB_C

InterPro
IPR008824
Domain

Holliday junction DNA helicase RuvB, N-terminal
PF05496	$\"[15-66]T$	RuvB_N

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[270-344]T$	no description

InterPro
IPR013159
Domain

Chromosomal replication initiator, DnaA C-terminal
SM00760	$\"[198-240]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.60	$\"[194-269]T$	no description
G3DSA:3.40.50.300	$\"[31-194]T$	no description
PTHR13779	$\"[37-344]T$	HOLLIDAY JUNCTION DNA HELICASE RUVB-RELATED
PTHR13779:SF2	$\"[37-344]T$	HOLLIDAY JUNCTION DNA HELICASE RUVB
signalp	$\"[1-15]?$	signal-peptide

","BeTs to 11 clades of COG2255COG name: Helicase subunit of the Holliday junction resolvase (RuvB)Functional Class: LThe phylogenetic pattern of COG2255 is ------vceB-hujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** PR00819 (CbxX/CfqX superfamily signature) with a combined E-value of 2e-10. PR00819A 37-51 PR00819B 67-82 PR00819D 107-126 PR00819G 180-199","Residues 260-331 are 58% similar to a (DNA HELICASE HOLLIDAY JUNCTION) protein domain (PD371854) which is seen in RUVB_BACSU.Residues 252-340 are 77% similar to a (DNA HELICASE HOLLIDAY JUNCTION) protein domain (PD005323) which is seen in RUVB_LACLA.Residues 177-246 are 52% similar to a (DNA RUVB HELICASE JUNCTION) protein domain (PD149882) which is seen in RUVB_SYNY3.Residues 94-142 are 75% similar to a (DNA HELICASE HOLLIDAY JUNCTION) protein domain (PD296654) which is seen in Q9KDI8_BACHD.Residues 145-240 are 67% similar to a (DNA HELICASE HOLLIDAY JUNCTION) protein domain (PD236006) which is seen in Q9KDI8_BACHD.Residues 34-92 are 66% similar to a (DNA HELICASE HOLLIDAY JUNCTION) protein domain (PD368934) which is seen in RUVB_ECOLI.Residues 42-175 are 87% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in RUVB_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 1 17:50:44 2006","Mon Oct 7 15:39:10 2002","Wed Feb 8 10:30:22 2006","Wed Apr 3 15:04:57 2002","Fri Dec 7 14:28:34 2001","Fri Dec 7 14:28:34 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0058 is weakly paralogous to SMu1866, a conserved hypothetical. Residues 33-151 are 33% similar to SMu1866.SMu0058 is paralogously related (blast p-value < 1e-3) to SMu1866.","Wed Jan 9 14:36:41 2002","","No significant hits to the NCBI PDB database.","SMU.64","","Residues 15 to 66 (E-value = 3.9e-30) place SMu0058 in the RuvB_N family which is described as Holliday junction DNA helicase ruvB N-terminus (PF05496)Residues 67 to 246 (E-value = 3.4e-26) place SMu0058 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)Residues 263 to 341 (E-value = 1.4e-49) place SMu0058 in the RuvB_C family which is described as Holliday junction DNA helicase ruvB C-terminus (PF05491)","Wed Feb 8 10:30:22 2006","24378590","","","McGlynn P, Lloyd RG.Action of RuvAB at Replication Fork Structures.J Biol Chem. 2001 Nov 9;276(45):41938-44.PMID: 11551967Putnam CD, Clancy SB, Tsuruta H, Gonzalez S, Wetmur JG, Tainer JA.Structure and mechanism of the RuvB Holliday junction branch migration motor.J Mol Biol. 2001 Aug 10;311(2):297-310.PMID: 11478862 Yamada K, Kunishima N, Mayanagi K, Ohnishi T, Nishino T, Iwasaki H, Shinagawa H, Morikawa K. Related Articles, Free in PMC Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1442-7. PMID: 11171970 ","","Fri Dec 7 14:44:35 2001","1","","","SMU.64","223" "SMu0059","66289","66714","426","ATGAAGAAAATTTGTTTTGTTTGTTTGGGTAATATCTGCCGCAGTCCTATGGCTGAATTTGTGATGAGAGAGGAAGCATCCGATGCGAGTCTAGAGATTGCCAGCCGGGCAACGTCAGGCTGGGAACATGGAAATCCTATTCATCGCGGAACGCAAGGGATTTTTAGAAAATATAAAATTGCTTATGATTCCTCTAAGAGATCTCAACGAATTAGTTTGGCTGATTTTGCTTACTTTGATTGGATCATTGGAATGGACGAGACTAATGTCTGTGATCTCAAAAGGTTATCTCAAGGACAATTTGATGATAAAATCTTTCTTTTTATTGATGGTGGTGTACCGGATCCTTACTATACCGGAGACTTCGAAGAAACTTATCATCTGGTCGAAAAGGGCTGTCAAACTTGGTTGAAAAAAATTAAATAG","6.70","-0.52","16207","MKKICFVCLGNICRSPMAEFVMREEASDASLEIASRATSGWEHGNPIHRGTQGIFRKYKIAYDSSKRSQRISLADFAYFDWIIGMDETNVCDLKRLSQGQFDDKIFLFIDGGVPDPYYTGDFEETYHLVEKGCQTWLKKIK","66711","","protein tyrosine-phosphatase","Cytoplasm","Several matches in gapped BLAST to protein-tyrosine phosphatases. Residues 1-140 are 64% similar to the enzyme from S.pyogenes (gi15674281) and are 59% similar to a conserved hypothetical from S.pneumoniae (gi15903881). See Spy0039.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0050 (1e-54).","

InterPro
IPR000106
Family

Low molecular weight phosphotyrosine protein phosphatase
PR00719	$\"[4-21]T$ $\"[78-93]T$ $\"[113-128]T$	LMWPTPASE
PTHR11717	$\"[8-141]T$	Low_mwt_PTPase
PF01451	$\"[2-139]T$	LMWPc
SM00226	$\"[2-139]T$	LMWPc

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.270	$\"[3-141]T$	G3DSA:3.40.50.270
PTHR11717:SF7	$\"[8-141]T$	PTHR11717:SF7
SSF52788	$\"[1-141]T$	SSF52788

","BeTs to 6 clades of COG0394COG name: Protein-tyrosine-phosphataseFunctional Class: TThe phylogenetic pattern of COG0394 is A-t-yQ-CEBR----------Number of proteins in this genome belonging to this COG is 1","***** PR00719 (LMW phosphotyrosine protein phosphatase signature) with a combined E-value of 2.8e-20. PR00719A 4-21 PR00719C 78-93 PR00719E 113-128","Residues 41-140 are 52% similar to a (PROTEOME COMPLETE PHOSPHATASE EIGHT) protein domain (PD375917) which is seen in Q9CDL7_LACLA.Residues 2-40 are 60% similar to a (PHOSPHATASE WEIGHT LOW MOLECULAR HYDROLASE) protein domain (PD002132) which is seen in Q9PN39_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 7 15:50:08 2002","Fri Dec 7 14:37:35 2001","Wed Feb 8 10:34:24 2006","Wed Apr 3 15:04:05 2002","Fri Dec 7 14:37:35 2001","Fri Dec 7 14:37:35 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0059 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Apr 3 15:04:05 2002","Wed Feb 8 10:34:24 2006","pdb5PNT Crystal Structure Of A Human Low Molecular Weight ... 90 2e-019pdb1DG9A Chain A, Crystal Structure Of Bovine Low Molecular W... 82 4e-017pdb1C0EA Chain A, Active Site S19a Mutant Of Bovine Heart Pho... 81 9e-017","SMU.65","","Residues 2 to 139 (E-value = 3.2e-28) place SMu0059 in the LMWPc family which is described as Low molecular weight phosphotyrosine protein phosphatase (PF01451)","Fri Dec 7 14:37:35 2001","24378591","","","Bennett MS, Guan Z, Laurberg M, Su XD.Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases.Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13577-82.PMID: 11698660 ","","Fri Dec 7 14:49:03 2001","1","","","SMU.65","743" "SMu0060","66779","67162","384","ATGATGAGAAAGATACAGATAACGAGAGAAAAATTAGAGCTGTTAGCAGTTATTGTCATCCTTGTATGTGGTTTATCTGTTTTCACCCTTAAATTTGGTAGCAAAGCAACCTTAACTTATGAAGGTGGTAAGATTAACTATACAGGCTATGTCCTCAATCATCGAATGAATGGTCAAGGAAAACTAACTTATCCTAATGGTGATGTTTATGAGGGACATTTTGTTAATGGTATTTTCAACGGTCATGGCCGCTTTAAGTCCAGCATGGGCTGGTCTTATGTTGGCGAGTTTAAAAAAGGACAAGCAGATGGTCATGGGAAATTAACGGCTAAGGACAAAAAAATTTATAAAGGGACATTTAAGCAAGGGATTTATCAAAAATGA","10.70","12.89","14231","MMRKIQITREKLELLAVIVILVCGLSVFTLKFGSKATLTYEGGKINYTGYVLNHRMNGQGKLTYPNGDVYEGHFVNGIFNGHGRFKSSMGWSYVGEFKKGQADGHGKLTAKDKKIYKGTFKQGIYQK","67159","","conserved hypothetical protein; possible phosphatidylinositol-4-phosphate 5-kinase","Cytoplasm, Extracellular, Membrane","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 1-127 are 59% similar to gi15674282 of S.pyogenes. Residues 4-127 are 48% similar to gi15901848 of S.pneumoniae.Residues 47-125 are 40% similar to gi15599211 of P.aeruginosa.See Spy0040.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0051 (5e-45).","

InterPro
IPR003409
Repeat

MORN motif
PF02493	$\"[47-69]T$ $\"[70-92]T$ $\"[93-115]T$	MORN
SM00698	$\"[45-66]T$ $\"[68-89]T$ $\"[91-112]T$	MORN

InterPro
IPR014590
Family

Predicted uncharacterised protein with MORN repeat, SP2027 type
PIRSF034300	$\"[2-127]T$	UCP034300

noIPR
unintegrated

unintegrated
G3DSA:2.20.110.10	$\"[46-120]T$	G3DSA:2.20.110.10
PTHR23084	$\"[46-123]T$	PTHR23084
SSF82185	$\"[43-123]T$	SSF82185

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 55-106 are 36% similar to a (PHOSPHATIDYLINOSITOL-4-PHOSPHATE KINASE 5-KINASE) protein domain (PD371638) which is seen in Q9C962_ARATH.Residues 47-124 are 33% similar to a (PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE JUNCTOPHILIN) protein domain (PD149995) which is seen in Q9C962_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 8 10:38:09 2006","Wed Feb 8 10:38:09 2006","Wed Feb 8 10:38:09 2006","Fri Dec 7 14:53:42 2001","","Fri Dec 7 14:53:42 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0060 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 7 15:50:48 2002","","No significant hits to the NCBI PDB database.","SMU.66","","Residues 47 to 69 (E-value = 1e-05) place SMu0060 in the MORN family which is described as MORN repeat (PF02493)","Fri Dec 7 14:53:42 2001","24378592","","","","","","1","","","SMU.66","873" "SMu0061","67159","68949","1791","ATGAGAATAAAATGGTTTTCTTTTGTTAGAGTTACAGGGCTGCTTTTGGTGCTGCTTTATCATTTTTTCCAACGAGCTTTTCCGGGCGGCTTTATAGGAGTAGACGTTTTCTTTACCTTTTCGGGTTATTTGATTACAGCTCTACTGATTGATGAATTTGCCAGAAATAAGATGATTGATCTTTTAGGCTTTCTAAGGCGGCGCTTCTATCGCATTGTACCGCCTGTTGTCATTATGGTTTTGGTCGTTCTGCCTTTTACTTTTTTGATTAGGAAGGATTTTGTGGCAGATATTGGCCGCCAAATTGCTTCTGTTCTAGGTTTTACAACTAACCTTTATGAAATTTTTACTGGCAGCAGTTACGAAAGCCAATTCATCCCCCACCTTTTTGTTCATACTTGGAGCCTAGCTATTGAAGTGCATTTTTACCTTTTTTGGGGGATTCTTGTCTGGTTCTTATCAAAAAAGGTTAAGGATCCTACGCAATTTCGCGGCCTTATCTTTTTGATTTCAGTTGGTTTATTTTTGCTGAGCTTCTTTACTATGTTTGCGCGTGCCTTTTTTGTTAATAGTTTTTCGACGATTTATTTTTCAACTTTGTCACATATTTTTCCTTTCTTTTTAGGAGCCATTTTTGCAACGATGTCAGGAATTAGTGAGACAACGAAACGCTTTAAGAAAAATGTGCAGCTCTGGCAGACCAAACGCGTTGTCTTTTTCATGGTTGGCAGTGCAGCCTTGTTATTTCTGTTGGGATTTATTCTTGACTTTAATAATATAATCACTTATTTATTTGGTTTTGCTTTAGCCAGTCTATTCACGGCTGTAATGGTTTATTCCAGCCGTGTCTTAAATGACCAAACGCCACATTTGCAAGAACCTGCTTTTGTTACTTATTTAGCTGATATCAGTTATGGTGTTTACCTTTTTCACTGGTCTTTTTATATTATCTTTGGGCAATTAATGAATAACTGGTTGGCTGTCATTTTTACGGTTCTTTTCTCTCTTACCTTTGCAACGATTTCTTATTATGTTGTTGAACCTTATATTGCAGGAAAGCAAGCTGTTTTGTTTGGGCTGGCTGTTCCTATTGAGCATTACAAAAAATGGTTCTACAGTTTGGCTGGTTTATTAACCGTTGTGACTTTAGGTATTGCCTTTACGGCACCAAGTGTCGGCTCTTTTGAAACAGGACTTTTAGTTGATGCGCTCAACCAAGCTGATAATAATATGAATCGGACACATACGCTGGCTGCTGGAGACGCAAGTGCTATTAGTGATATCACTGTTATTGGTGACTCAGTTGCTTTGCGCTCAAGTACTGCTTTTTCTGAACTTCTGCCGGAAGCTCAGGTAGATGCGGCAGTTAGCCGTAATTTTGGGAATGCCTATGATATTTTTAAAAATCATATTGATAATAGTACATTATCAAAAACAGTTGTTTTAGCGGTTGGAGTTAATTCGGTTGAAGGTTACAAAGATAATATTCAACAATTCATTGATAATCTCCCGGATGGACATCGACTTATTATTGTGACTCCTTATAATACTAAAGATGAACGTATTCCAGATGTTCGTGATTACGAATTAGATTTAGCAAAGAAATATCAGTTTGTCACGATAGCTGATTGGTATCAAGCAGCTGTGGCACATCCTGAAATTTGGACAGAATCTGATGGTGTTCACTATAATGACAGCAGTGATGAAGGTGCTAAACTTTATGTCGAAACTATAAAAAAAGCCATTCAGACATCTGCAAAGCAGCCTGCTAAGGGTGAAAAACAACCCTAG","7.50","2.15","67500","MRIKWFSFVRVTGLLLVLLYHFFQRAFPGGFIGVDVFFTFSGYLITALLIDEFARNKMIDLLGFLRRRFYRIVPPVVIMVLVVLPFTFLIRKDFVADIGRQIASVLGFTTNLYEIFTGSSYESQFIPHLFVHTWSLAIEVHFYLFWGILVWFLSKKVKDPTQFRGLIFLISVGLFLLSFFTMFARAFFVNSFSTIYFSTLSHIFPFFLGAIFATMSGISETTKRFKKNVQLWQTKRVVFFMVGSAALLFLLGFILDFNNIITYLFGFALASLFTAVMVYSSRVLNDQTPHLQEPAFVTYLADISYGVYLFHWSFYIIFGQLMNNWLAVIFTVLFSLTFATISYYVVEPYIAGKQAVLFGLAVPIEHYKKWFYSLAGLLTVVTLGIAFTAPSVGSFETGLLVDALNQADNNMNRTHTLAAGDASAISDITVIGDSVALRSSTAFSELLPEAQVDAAVSRNFGNAYDIFKNHIDNSTLSKTVVLAVGVNSVEGYKDNIQQFIDNLPDGHRLIIVTPYNTKDERIPDVRDYELDLAKKYQFVTIADWYQAAVAHPEIWTESDGVHYNDSSDEGAKLYVETIKKAIQTSAKQPAKGEKQP","68946","","acyltransferase","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to acyltransferases and hypothetical proteins. Residues 1-591 are 62% similar to a predicted acyltransferase in S.pyogenes (gi15674283). Residues 1-593 are 49% similar to gi15901877 in S.pneumoniae.See Spy0041.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0052 (0.0).","

InterPro
IPR002656
Domain

Acyltransferase 3
PF01757	$\"[3-353]T$	Acyl_transf_3

InterPro
IPR013830
Domain

Esterase, SGNH hydrolase-type
SSF52266	$\"[425-587]T$	Esterase_SGNH_hydro-type

noIPR
unintegrated

unintegrated
PTHR23028	$\"[27-346]T$	PTHR23028
PTHR23028:SF7	$\"[27-346]T$	PTHR23028:SF7

","BeTs to 3 clades of COG1835COG name: Predicted acyltransferasesFunctional Class: IThe phylogenetic pattern of COG1835 is ---------bRh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 27-318 are 26% similar to a (TRANSFERASE COMPLETE PROTEOME) protein domain (PD001392) which is seen in Q9XTD1_CAEEL.Residues 428-582 are 28% similar to a (PROTEOME COMPLETE YVHB) protein domain (PD415526) which is seen in O05402_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 8 10:40:29 2006","Fri Dec 7 14:56:45 2001","Wed Feb 8 10:40:29 2006","Wed Feb 8 10:40:29 2006","","Fri Dec 7 14:56:45 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0061 is paralogously related (blast p-value < 1e-3) to SMu0890.","Tue Oct 8 16:35:21 2002","","No significant hits to the NCBI PDB database.","SMU.67","","Residues 3 to 353 (E-value = 2.9e-25) place SMu0061 in the Acyl_transf_3 family which is described as Acyltransferase family (PF01757)","Fri Dec 7 14:56:45 2001","24378593","","","","","","1","","","SMU.67","10" "SMu0062","69215","69292","78","ATGTCTGCTTTGTTTTATGATACCTTAGCAGCAATTTGGATTTCTATTGCTGGCGTGGATGCTCGTTGGGGTCATTAA","5.40","-0.78","2747","MSALFYDTLAAIWISIAGVDARWGH","69289","","hypothetical protein","Extracellular, Cytoplasm","No significant hits in gapped BLAST.SMu0062 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide

InterPro
IPR000634
Binding_site

Serine/threonine dehydratase, pyridoxal-phosphate-binding site
PS00165	$\"[102-116]?$	DEHYDRATASE_SER_THR

InterPro
IPR001926
Domain

Pyridoxal-5'-phosphate-dependent enzyme, beta subunit
PF00291	$\"[83-392]T$	PALP

InterPro
IPR004450
Domain

Threonine synthase
TIGR00260	$\"[54-444]T$	thrC

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1100	$\"[198-451]T$	G3DSA:3.40.50.1100
G3DSA:3.90.1380.10	$\"[3-86]T$	G3DSA:3.90.1380.10
PTHR10314	$\"[20-395]T$	PTHR10314
PTHR10314:SF1	$\"[20-395]T$	PTHR10314:SF1
SSF53686	$\"[3-493]T$	SSF53686

","BeTs to 10 clades of COG0498COG name: Threonine synthaseFunctional Class: EThe phylogenetic pattern of COG0498 is AmtKyQvCebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000634 (Serine/threonine dehydratase pyridoxal-phosphate attachment site) with a combined E-value of 1.6e-06. IPB000634A 101-115 IPB000634B 264-274 IPB000634C 275-294","Residues 5-153 are 68% similar to a (THREONINE SYNTHASE LYASE BIOSYNTHESIS) protein domain (PD342929) which is seen in Q9CDV8_LACLA.Residues 281-438 are 49% similar to a (THREONINE SYNTHASE LYASE PYRIDOXAL) protein domain (PD005074) which is seen in Q9CDV8_LACLA.Residues 161-213 are 41% similar to a (THREONINE SYNTHASE PROTEOME PYRIDOXAL) protein domain (PD349826) which is seen in Q9CPD2_PASMU.Residues 162-216 are 41% similar to a (THREONINE SYNTHASE PYRIDOXAL LYASE) protein domain (PD336140) which is seen in THRC_HELPY.Residues 224-279 are 57% similar to a (THREONINE SYNTHASE LYASE BIOSYNTHESIS) protein domain (PD343633) which is seen in Q9CDV8_LACLA.Residues 162-207 are 73% similar to a (THREONINE SYNTHASE LYASE PYRIDOXAL) protein domain (PD402793) which is seen in Q9CDV8_LACLA.Residues 444-494 are 58% similar to a (PROTEOME THREONINE COMPLETE SYNTHASE) protein domain (PD385533) which is seen in Q9CDV8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri May 20 13:25:02 2005","Fri Dec 7 15:07:03 2001","Fri May 20 13:25:02 2005","Wed Apr 3 15:07:47 2002","Fri Dec 7 15:07:03 2001","Fri Dec 7 15:07:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs in S.mutans.SMu0063 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Apr 3 15:07:47 2002","","No significant hits to the NCBI PDB database.","SMU.70","","Residues 83 to 392 (E-value = 1.8e-08) place SMu0063 in the PALP family which is described as Pyridoxal-phosphate dependent enzyme (PF00291)","Fri Dec 7 15:07:03 2001","24378595","","","Laber B, Lindell SD, Pohlenz HD.Inactivation of Escherichia coli threonine synthase by DL-Z-2-amino-5-phosphono-3-pentenoic acid.Arch Microbiol. 1994;161(5):400-3.PMID: 8042902 Farrington GK, Kumar A, Shames SL, Ewaskiewicz JI, Ash DE, Wedler FC.Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate.Arch Biochem Biophys. 1993 Nov 15;307(1):165-74.PMID: 7902068Parsot C.Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase.EMBO J. 1986 Nov;5(11):3013-9.PMID: 3098560","","Fri Dec 7 15:15:23 2001","1","","","SMU.70","11" "SMu0064","71523","72872","1350","TTGCTTGAAAATTCAATAACATATGAAAAACCTTTATACATAATCAAGATGAATCAAAGAAAGAAAATTGTTCAAATTGCTTTACCAGCTATGGCAGAGAATTTACTGCAAATGCTAATGGGAGTTGTTGATAACTATTTAGTGGCTCAGATTGGCTTAGTTGCTGTATCTGGTGTTTCGGTTGCTAATAATATTATTACGATTTATCAGGCTATTTTTATTGCACTTGGGGCGGCAGTATCCAGTTTAGTGGCTAAAAGTTTAGGTGAAGATAACCAAGCCAGAGTGAGGTTTTATCAGTCTGAGTCTGTTGCTATTACATTAATGCTGAGTGTAGTGTTAGGGTTTATATCTTTTGTTTTTGGTAGCAATATGCTTCATCTTTTAGGAACAACAGATAGTGTCACACAGGCAGGAGGAATTTATTTAGCTATTGTTGGCGGTTTAGTTGTCAGTCTTGGCTTACAAACGACGCTGGGTGCTATTTTGAGAGCACAAGGGAAAGCACGTTTGCCCATGTATGTCAGTTTTCTAACCAATATTGTTAATGTTATTTTAGCAACTACAGCTATTTATATTGGACATTGGGGAATTGTTGGAGTTGCGGCAGCAACAGTCCTTTCACGTTTTCTTGGAACCTTCGTTTTAGCTTGTCAATTACCAATTAAAGCTATTTTGAGGTCAATGAGAATTAAAATTGACAAGGCCTTCCTAGCTATTGCTTTGCCTTCAGCTGGTGAGCGTTTAATGATGCGAGCAGGTGATGTTGTTATTATTGCTATTATCGTTAAATTTGGGACAGCTGCGGTAGCTGGAAATGCTATTGGTGAGACCCTGACACAGTTTAATTATATGCCGGGAATGGGGGTTGCCACAGCAACAGTTATCTTAGTGGCCCATAATTTAGGGCAAGGAAAAAAGAAGGTCATTAAGGAAGTCGTTAGAGAATCTTATATTATTTCTACCGTATTTATGCTGTTAGTAGGAGCATGCATCTTTTTTGGAGGTAGGCAGCTAACCTATCTTTTTACAGAAAATAAAGCAGCTCTTCAGGCGAGCTTAGTTGTGTTGTTTTATTCTTTTATAGGGGGGCCAGCAACATCAGGAACTCTGGTTTTCACAGCAGTTTGGCAAGGTCTAGGAAAAGCTAAATTGACTTTCTATGCAACGACGGTTGGTATGTGGTTGATTCGGATTGTGTTAGGTTATTATTTAGGTGTCAGTTTAAATCTTGGTTTAGCGGGTGTTTGGTTAGCAACCTTAGCTGATAATGTTTTTAGATGGCTGTTTCTCTATTGCTTGTATAGAAAGTATATGCAGGGATTCAATAATAACCTATCCAGTTCATAA","10.60","17.57","48296","MLENSITYEKPLYIIKMNQRKKIVQIALPAMAENLLQMLMGVVDNYLVAQIGLVAVSGVSVANNIITIYQAIFIALGAAVSSLVAKSLGEDNQARVRFYQSESVAITLMLSVVLGFISFVFGSNMLHLLGTTDSVTQAGGIYLAIVGGLVVSLGLQTTLGAILRAQGKARLPMYVSFLTNIVNVILATTAIYIGHWGIVGVAAATVLSRFLGTFVLACQLPIKAILRSMRIKIDKAFLAIALPSAGERLMMRAGDVVIIAIIVKFGTAAVAGNAIGETLTQFNYMPGMGVATATVILVAHNLGQGKKKVIKEVVRESYIISTVFMLLVGACIFFGGRQLTYLFTENKAALQASLVVLFYSFIGGPATSGTLVFTAVWQGLGKAKLTFYATTVGMWLIRIVLGYYLGVSLNLGLAGVWLATLADNVFRWLFLYCLYRKYMQGFNNNLSSS","72869","","MATE efflux family protein","Membrane, Cytoplasm","Numerous matches in gapped BLAST to conserved hypotheticals and to predicted Multi antimicrobial extrusion proteins (MATE). Residues 19-439 are 53% similar to a predicted MATE protein from S.pneumoniae (gi15903918).This sequence is similar to Spy0045.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0056 (1e-140).","

InterPro
IPR002528
Family

Multi antimicrobial extrusion protein MatE
PTHR11206	$\"[43-437]T$	MULTIDRUG RESISTANCE PUMP
PF01554	$\"[29-189]T$ $\"[243-404]T$	MatE
TIGR00797	$\"[29-417]T$	matE: MATE efflux family protein

InterPro
IPR013248
Family

Shr3 amino acid permease chaperone
SM00786	$\"[102-256]T$	no description

noIPR
unintegrated

unintegrated
PTHR11206:SF7	$\"[43-437]T$	MULTIDRUG RESISTANCE PUMP
tmhmm	$\"[38-60]?$ $\"[66-84]?$ $\"[104-122]?$ $\"[141-163]?$ $\"[172-192]?$ $\"[198-220]?$ $\"[256-274]?$ $\"[284-302]?$ $\"[317-337]?$ $\"[356-376]?$ $\"[385-405]?$ $\"[411-431]?$	transmembrane_regions

InterPro
IPR002912
Domain

Amino acid-binding ACT
PF01842	$\"[7-72]T$	ACT

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.260	$\"[1-88]T$	no description

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-92 are 50% similar to a (PROTEOME COMPLETE REPRESSOR PHOSPHOSERINE) protein domain (PD029187) which is seen in Q9CGZ6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:40:07 2002","Fri Dec 7 15:57:17 2001","Tue Oct 8 16:40:07 2002","Fri Dec 7 15:57:17 2001","","Fri Dec 7 15:57:17 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0065 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 7 15:57:17 2001","","No significant hits to the NCBI PDB database.","SMU.72","","Residues 7 to 78 (E-value = 8e-07) place SMu0065 in the ACT family which is described as ACT domain (PF01842)","Fri Dec 7 15:57:17 2001","161486825","","","","","","1","","","SMU.72","" "SMu0066","73517","74854","1338","ATGGATATTAAACAGGTTACCGAAACGATTGCAATGATTGAAGAGCAGAATTTTGATGTTCGGACAATTACCATGGGAATTTCGCTTCTTGATTGTATTGATTCGAATATTGAAAAAGCAGCTGAAAAGGTTTATCACAAAATTGTAACCAAAGCTGGCAAGTTGGTTCAAGTGGGGGACGATATTTCAGCAGAACTCGGTATTCCAATTGTTAATAAGCGTGTATCGGTTACACCGATTTCAATTATTGGTGCAGCAACAGATGCGACGGATTATGTGCCCTTAGCTAAGGCGCTTGACCGTGCGGCAAAAGAGATTGGAGTGAATTTTATCGGTGGTTTTTCTGCTTTAGTACAAAAAGGCTATCAAAAAGGGGATGAAATTCTTATTAATTCGATCCCAAAAGCTCTTGCTGAAACGGACTTTGTCTGTTCATCTGTTAATATTGGTTCAACCAAGTCGGGAATCAACATGACAGCTGTCCGCGATATGGGACGCATTATTAAAGAGACCTCAGCGGCTTCAGAAATGGGACCGGCAAAATTGGTTGTTTTTGCCAATGCAGTAGAAGATAATCCTTTTATGGCAGGAGCCTTTCACGGTGTTGGGGAAGCAGATGTTGTCATCAATGTTGGTGTTTCTGGACCGGGTGTTGTCAAGCGTGCCTTAGAAAAGGTTCGCGGTCAAAGTTTTGATGTGGTGGCTGAGACTGTTAAGAAAACGGCTTTTAAAATTACCCGTATTGGTCAGTTAGTCGGTAGCTTGGCTAGTGAACGTCTTGGTGTCAAATTTGGTATTGTGGATTTATCTCTTGCACCGACGCCGGCTGTCGGAGATTCTGTAGCTCGTGTTCTTGAAGAAATGGGACTGGAAACCATCGGAACTCATGGGACAACAGCGGCCTTGGCACTCCTCAATGATCAGGTTAAAAAAGGCGGTGTTATGGCTTGTAATCAAGTCGGTGGTCTCTCGGGTGCTTTTATTCCGGTTTCCGAAGATGAGGGGATGATTGCTGCTGTGCAGGAGGGGGCTCTTAATCTGGAAAAATTAGAAGCCATGACAGCTATCTGCTCGGTTGGTCTTGACATGATTGCCATCCCGGCAAATACACCAGATACGACGATTGCAGCCATGATTGCAGACGAAGCGGCTATCGGTGTTATCAATCAAAAAACAACAGCTGTTCGTATTATTCCTAAAGGTAAAGAGGGGGATATGATTGAATTTGGCGGTTTACTCGGTTATGCTCCTGTCATGCCGGTTAATAAAAAATCATCTGCAGACTTTATTGCGCGTGGCGGACAGATTCCGGCACCTATTCATAGCTTTAAAAATTAA","5.10","-8.19","46381","MDIKQVTETIAMIEEQNFDVRTITMGISLLDCIDSNIEKAAEKVYHKIVTKAGKLVQVGDDISAELGIPIVNKRVSVTPISIIGAATDATDYVPLAKALDRAAKEIGVNFIGGFSALVQKGYQKGDEILINSIPKALAETDFVCSSVNIGSTKSGINMTAVRDMGRIIKETSAASEMGPAKLVVFANAVEDNPFMAGAFHGVGEADVVINVGVSGPGVVKRALEKVRGQSFDVVAETVKKTAFKITRIGQLVGSLASERLGVKFGIVDLSLAPTPAVGDSVARVLEEMGLETIGTHGTTAALALLNDQVKKGGVMACNQVGGLSGAFIPVSEDEGMIAAVQEGALNLEKLEAMTAICSVGLDMIAIPANTPDTTIAAMIADEAAIGVINQKTTAVRIIPKGKEGDMIEFGGLLGYAPVMPVNKKSSADFIARGGQIPAPIHSFKN","74851","","conserved hypothetical protein","Cytoplasm","Numerous matches in gapped BLAST to conserved hypotheticals. Residues 1-445 are 90% similar to gi15902262 of S.pneumoniae and 82% similar to gi15672929 of Lactococcus.SMu0066 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007841
Family

Protein of unknown function DUF711
PF05167	$\"[1-445]T$	DUF711

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 253-445 are 86% similar to a (PROTEOME YJHD COMPLETE) protein domain (PD399978) which is seen in Q9CGZ5_LACLA.Residues 1-252 are 79% similar to a (PROTEOME COMPLETE YJHD NMB1652) protein domain (PD141925) which is seen in Q9CGZ5_LACLA.Residues 253-421 are 76% similar to a (PROTEOME COMPLETE NMB1652 APE2446) protein domain (PD332683) which is seen in Q9JTA4_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 5 11:00:21 2005","Fri Dec 7 16:00:43 2001","Tue Jul 5 11:00:21 2005","Fri Dec 7 16:00:43 2001","","Fri Dec 7 16:00:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0066 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 7 16:00:43 2001","","No significant hits to the NCBI PDB database.","SMU.73","","Residues 1 to 445 (E-value = 8.5e-274) place SMu0066 in the DUF711 family which is described as Uncharacterized ACR (DUF711) (PF05167)","Fri Dec 7 16:00:43 2001","24378598","","","Okwumabua O, Chinnapapakkagari S.Identification of the gene encoding a 38-kilodalton immunogenic and protective antigen of Streptococcus suis.Clin Diagn Lab Immunol. 2005 Apr;12(4):484-90.PMID: 15817754","","Tue Jul 5 11:00:21 2005","1","","","SMU.73","" "SMu0067","74927","75637","711","ATGGCAGAAACAAGACTCTATATAGCTAGACACGGAAAGACAATGTTTAATACAATTGGCCGTGCTCAAGGTTGGAGTGATACTCCTCTTACACAAGCGGGTGAAGAAGGGATACGGGAATTGGGAATTGGTTTAAGGGAAGCCCGTATCCCTTTTAAAGCCGCTTTTTCCAGTGACAGCGGCAGAACCATGCAAACAATGGAGATTATCCTTCGTGAAACGAATAATGAGAATTTGCCTTATGTACGAGATAAACGGATTCGAGAATGGTGCTTTGGGAGTCTCGATGGAGGATATGATGGGGATCTTTTCCAAGGTGTCTTGCCTCGAACAGCAGCTTTTAATACTGGCAAATCCTTTGAAGAAGTGACTTACCCTGAATTAGCAGCTAGTATCGTTGAAGTGGACACAGCTAATTGGGCTGAACCTTGGCAGATTCTTAGCAAACGTATTTATGATGGTTTTGAAGCTATGGCACAAACAGTTGAACAATCTGGAGGCGGAAATGCTATTATAGTCAGCCATGGAATGACTATTGGTACTTTTATGTGGCTGATAGATCATAAGCAGGAAAAAGCGGCTATTGATAATGGCAGTGTTTCTGTTGTTTCCTATAAAGATAATACGTTTTCTATTGAAACGATTGCAGATATGTCTTATCGTCATCAAGGAAGAAAAATTTTGGAAGATATTTATGAAGAGAAATTCTAG","4.90","-8.07","26511","MAETRLYIARHGKTMFNTIGRAQGWSDTPLTQAGEEGIRELGIGLREARIPFKAAFSSDSGRTMQTMEIILRETNNENLPYVRDKRIREWCFGSLDGGYDGDLFQGVLPRTAAFNTGKSFEEVTYPELAASIVEVDTANWAEPWQILSKRIYDGFEAMAQTVEQSGGGNAIIVSHGMTIGTFMWLIDHKQEKAAIDNGSVSVVSYKDNTFSIETIADMSYRHQGRKILEDIYEEKF","75634","For other 'gpm' genes see SMu0543 (gpmA); SMu0640 (gpmB); SMu1008 (gpm); SMu1009 (gpm) and SMu1010 (gpm).This may or may not be a cofactor independent pgm. ","phosphoglycerate mutase-like protein","Cytoplasm","Several matches in gapped BLAST to phosphoglycerate mutase sequences. Residues 1-234 are 65% similar to the predicted enzyme from S.pyogenes (gi15675611). Residues 1-230 are 53% similar to the phosphoglycerate mutase 2 paralog of S.pneumoniae (gi15902263).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0092 (2e-82).","

InterPro
IPR013078
Domain

Phosphoglycerate mutase
PF00300	$\"[5-182]T$	PGAM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1240	$\"[4-213]T$	G3DSA:3.40.50.1240
PIRSF001490	$\"[4-236]T$	DPGAM
PTHR23029	$\"[4-127]T$ $\"[143-220]T$	PTHR23029
SSF53254	$\"[4-233]T$	SSF53254

","BeTs to 6 clades of COG0406COG name: Phosphoglycerate mutase/fructose-2,6-bisphosphataseFunctional Class: GThe phylogenetic pattern of COG0406 is ----YQvCEbR----------Number of proteins in this genome belonging to this COG is 4","***** IPB001345 (Phosphoglycerate mutase family) with a combined E-value of 2.9e-16. IPB001345A 6-35 IPB001345B 55-67 IPB001345C 79-110 IPB001345D 139-157","Residues 94-228 are 49% similar to a (PROTEOME PHOSPHOGLYCERATE COMPLETE MUTASE) protein domain (PD397672) which is seen in Q9CGZ3_LACLA.Residues 10-93 are 61% similar to a (MUTASE PROTEOME COMPLETE PHOSPHOGLYCERATE PGAM) protein domain (PD000730) which is seen in Q9CGZ3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 22 10:06:23 2006","Fri Dec 7 16:13:57 2001","Tue Aug 22 10:06:23 2006","Wed Apr 3 15:14:11 2002","Fri Dec 7 16:13:57 2001","Fri Dec 7 16:13:57 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0067 is paralogously related (blast p-value < 1e-3) to SMu1008, SMu1010, SMu0640, SMu1009, and SMu0543, all of which have properties of phosphoglycerate mutase. Residues 4-122 are 34% similar to SMu1008.","Fri Dec 7 16:17:01 2001","","No significant hits to the NCBI PDB database.","SMU.74","","Residues 4 to 213 (E-value = 3.2e-11) place SMu0067 in the PGAM family which is described as Phosphoglycerate mutase family (PF00300)","Fri Dec 7 16:13:57 2001","24378599","","","Rigden DJ, Bagyan I, Lamani E, Setlow P, Jedrzejas MJ.A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase.Protein Sci. 2001 Sep;10(9):1835-46.PMID: 11514674Bond CS, White MF, Hunter WN.High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase.J Biol Chem. 2001 Feb 2;276(5):3247-53.PMID: 11038361","","Fri Dec 7 16:13:57 2001","1","","","SMU.74","512" "SMu0068","75621","76370","750","ATGAAGAGAAATTCTAGTTTATTAACAATTGTGCTGCAAATAGGTATTATCTTTGTTTTCATTTTGGGCATTTATCTTTTTTTACATAAAGGTAAACAAGGGGCACAAGAAAATACGGTAGGGAACAAAACGCAGCAAGCTGCTGAGACAAAAAAGAGCAAACAAACAGCAGGCTTACCAAATGTTTCAGCAAATGATTGGGAGTTAGTTTTGGTTAATCGTGATCATATCACTGCTGAAATGAACCCTGATGTAACTGATATTGATGGTGTTAAGGTGGATTCTCGCATTGCAGAAAATACAAGGAAATTTTTAGCAGCTGCGCAAGAAATTGACTCCAGTGAACATTTGATATCAGGCTATCGTAGTGTTGCCTATCAAGAAGAACTCTATAATAATTATATAGCTCAAGAAAAAGCCAACAATCCCAGCCTTAGCCAAGAGGAGGCGCAAAAACAGGTTCAAACCTATTCTCAGCCGCCGGGTTCTAGTGAACACCAAACGGGACTGGCTATTGATATGAGTACAGTTGACAGTCTTAATCAAAGTGACGCTAATGTCGTTGCCAAGGTTGCTGCCATTGCGCCTAAATATGGTTTTGTCCTTCGTTTTCCTGAAGGTAAAAAGGATGCTACGGGTATTGATTATGAGGACTGGCACTATCGCTATGTTGGTGTTAAATCTGCTAAGTATATGACCAAACATGATTTAACCTTAGAAGAATATTTAAAAAAATTAAAGGAGAAGTAG","6.50","-1.55","27831","MKRNSSLLTIVLQIGIIFVFILGIYLFLHKGKQGAQENTVGNKTQQAAETKKSKQTAGLPNVSANDWELVLVNRDHITAEMNPDVTDIDGVKVDSRIAENTRKFLAAAQEIDSSEHLISGYRSVAYQEELYNNYIAQEKANNPSLSQEEAQKQVQTYSQPPGSSEHQTGLAIDMSTVDSLNQSDANVVAKVAAIAPKYGFVLRFPEGKKDATGIDYEDWHYRYVGVKSAKYMTKHDLTLEEYLKKLKEK","76367","For other 'dac' genes see SMu0230 (dacA).","D-alanyl-D-alanine carboxypeptidase (penicillin binding protein)","Membrane, Extracellular, Cytoplasm","A previously sequenced SMu0068 appears in Genbank as gi4098487gbAAD00280.1. Residues 77-236 are identical to residues 1-160 of this sequence.Several matches in gapped BLAST to D-alanyl-D-alanine carboxypeptidase sequences. Residues 1-236 are 59% similar to the enzyme from S.pyogenes (gi15675610).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0093 (3e-68).","

InterPro
IPR003709
Domain

Peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysins
PF02557	$\"[90-226]T$	VanY

InterPro
IPR009045
Domain

Hedgehog/DD-peptidase, zinc-binding motif
SSF55166	$\"[67-238]T$	Hedgehog_sig_N

","BeTs to 4 clades of COG1876COG name: D-alanyl-D-alanine carboxypeptidaseFunctional Class: MThe phylogenetic pattern of COG1876 is -------C-b------ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 32-157 are 32% similar to a (CARBOXYPEPTIDASE DD-CARBOXYPEPTIDASE ALL) protein domain (PD119668) which is seen in Q9KHM1_ENTFA.Residues 1-155 are 41% similar to a (CARBOXYPEPTIDASE PROTEOME COMPLETE) protein domain (PD398641) which is seen in Q9CGZ2_LACLA.Residues 161-236 are 45% similar to a (CARBOXYPEPTIDASE PROTEOME) protein domain (PD289010) which is seen in O34866_BACSU.Residues 156-225 are 78% similar to a (CARBOXYPEPTIDASE PROTEOME COMPLETE XF0881) protein domain (PD180828) which is seen in Q9CGZ2_LACLA.Residues 117-223 are 38% similar to a (CARBOXYPEPTIDASE DD-CARBOXYPEPTIDASE) protein domain (PD009837) which is seen in Q9EV49_STAXY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 24 11:41:28 2006","Fri Dec 7 16:28:36 2001","Mon Jul 24 11:36:26 2006","Wed Apr 3 15:18:28 2002","","Fri Dec 7 16:20:57 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0068 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 7 16:28:36 2001","","No significant hits to the NCBI PDB database.","SMU.75","","Residues 90 to 242 (E-value = 7.3e-83) place SMu0068 in the VanY family which is described as D-alanyl-D-alanine carboxypeptidase (PF02557)","Fri Dec 7 16:20:57 2001","24378600","","","","Mon Jul 24 11:36:26 2006","","1","","","SMU.75","618" "SMu0069","76374","76961","588","ATGAGAGCAAGACTCAAATTTAAGTCTTTTGTTGTAATTGTTTTACTTCTTTTGCTGGTGATTTTGCTCCCGATTTTGGCGAGTGGAGGATTGGCCGATGCTAACAAAAAAATGCCAAGTCCTTATAGTCATAAAGAGTTTGTCAAAGAAATTGCTCCAACAGCTCAAAAGTTATCAAAAATCTATGGCGTGAGGAGTTCTATTATTATTGGACAAGCAGCGCTGGATAGTCATTTTGGCAGTACTTTGCTAGCTAGTAAATATCACAATCTTTTTAGCATTGAAGCAAGTCCAGGTCAAGGAGCTGTTCGCTTAAAAAGCCATGAGTACAAGAATGGGCGTTGGCAGGAAGTGACAAATCGCTACCTTGTTTATGAATCTTGGAAAGAATCCCTTTATGATTACATGGCTATTCTACATGGAAATAAAATTTGGGATAAGGCACTGTATACAACGATGATGACTTCTAGTGGTTATAAAACAGTTGCAAGAGCCTTACAAGCAGCTGGTTTTAATAGTGATCCTAACTATGCAGACAAGTTAATAGCTGTTATAGAGGAAAATAATTTAACAGATTATGATAAATAG","10.30","8.19","21868","MRARLKFKSFVVIVLLLLLVILLPILASGGLADANKKMPSPYSHKEFVKEIAPTAQKLSKIYGVRSSIIIGQAALDSHFGSTLLASKYHNLFSIEASPGQGAVRLKSHEYKNGRWQEVTNRYLVYESWKESLYDYMAILHGNKIWDKALYTTMMTSSGYKTVARALQAAGFNSDPNYADKLIAVIEENNLTDYDK","76958","Ajdic et al., 2002, regard this to be an autolysin.","N-acetyl-muramidase (N-acetylmuramoyl-L-alanine amidase)","Extracellular, Membrane, Cytoplasm","This sequence corresponds to the previously sequenced gi4098486 in GenBank, a predicted N-acetyl-muramidase.Several matches in gapped BLAST to N-acetyl muramidase sequences, e.g. residues 1-194 are 41% simiar to the enzyme from S.pyogenes (gi15675609). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0094 (7e-34).","

InterPro
IPR000423
Family

Flagellar protein FlgJ type-1
PR01002	$\"[42-65]T$ $\"[66-84]T$ $\"[151-170]T$ $\"[171-189]T$	FLGFLGJ

InterPro
IPR002901
Domain

Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase
PF01832	$\"[51-190]T$	Glucosaminidase

InterPro
IPR013338
Domain

Lysozyme subfamily 2
SM00047	$\"[37-194]T$	LYZ2

","BeTs to 3 clades of COG1705COG name: Flagellar biosynthesis protein FlgJ, probable N-acetylmuramidaseFunctional Class: NThe phylogenetic pattern of COG1705 is ------v-eb-----------Number of proteins in this genome belonging to this COG is 1","***** IPB002901 (N-acetylmuramoyl-L-alanine amidase (family 4)) with a combined E-value of 2e-06. IPB002901A 84-100 IPB002901B 163-181","Residues 46-180 are 42% similar to a (COMPLETE PROTEOME FLAGELLAR) protein domain (PD007611) which is seen in Q9CFV0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 08:43:31 2006","Wed Dec 12 12:46:00 2001","Thu Sep 7 08:43:31 2006","Thu Sep 7 08:43:31 2006","Wed Dec 12 12:35:00 2001","Wed Dec 12 12:35:00 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0069 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 12:46:00 2001","","No significant hits to the NCBI PDB database.","SMU.76","","Residues 51 to 190 (E-value = 3e-12) place SMu0069 in the Amidase_4 family which is described as Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase (PF01832)","Wed Dec 12 12:35:00 2001","24378601","","","Shida T, Hattori H, Ise F, Sekiguchi J.Mutational analysis of catalytic sites of the cell wall lytic N-acetylmuramoyl-L-alanine amidases CwlC and CwlV.J Biol Chem. 2001 Jul 27;276(30):28140-6.PMID: 11375403","Thu Sep 7 08:43:31 2006","Wed Dec 12 12:46:00 2001","1","","","SMU.76","880" "SMu0070","77576","81847","4272","ATGGAAGAAGAAACAGTTTGTAAAAATTGGTTCATGCGTAAAAGTGGTAAAAGCTGGATTTTTGGCTGTGCCGTCTTTTTTGTGTTAGGTTTGGCAACTGCTTTACCGGTGGCAGCTGAAGAAATAAGTCAAACAACTGCTGCTGATACTGCTGTTACAGAAGTAAGAACAGAAGACAGCAGCCAGACGTCATCTCAAGAAACCGCAGTTACAGAAACGACTCAATCTGAGGGAACTGCTTCAAAACAACTGACAACTCCGGCGGTAGCAGATCAAACTACAGAGCCTACTGATAATGAACCCATCAGTTCCTCTGATGGTGCGAGCAGTCCTTATCAAGTGACTGACACGACAGAACCTCAACAAACTCTCACTCCTGCTGACTCTGAACCTCAAGCAAAGGCGGATGTTCAACAAGCAGCAGCTCCTAAGAAAGAAGAGATCAACCCTGTGACCAATTTAGAAGATATGTCACATGATACGAATGGGACTTGGGAAGTACGAGAAGATGGTATTCATTCTAATGCCATTGGTAAAGGTGATTCTTTCTTGTATTCTCAGTCAAGTGGTAAGAATTTTGTCTATGCAACAGATGTTACTTTTAAACAAAACAGCGGTGCAGCAGCTCTTGTTTTTAGAAGTAACAACGATAGCAATAACAAAAATATGTATGCGGTCAATGTGGATATAGGCGGACACAAGGCTAAATTTTGGCGTTGGGTTGACAATAAAGATATCCAATTAATTGATGAACGTGATGTGGTACCGACAGCTGATAACCGCTATACTCTTAAGGTTGTGGCGGTTAATAACTGGATTTCTTATTATGTCAATGATATTTTGATGGCTAGCACAGGTGATTATGTCCTTCAAAAAGCTGATAAAGGACAAAACACTGTCATTCCTGAGGGACACTTTGGTCTTTTGAATTGGAATGGCGATATGGTTTTCCAAAATACAAAATTTGCCCTATTGGATGATACAACAGCTCCGTTGATTGATAATATTACAGTAAGGTCTGATAGAGGGAATGTCGAAAAACAAGGTCAATTCTTCTCTGAGGAACCCCTTCATATTCAATATGTTAGCAATGATGCCTCTCAAGTGAGCTTGGATATTGCTAAACATAATCCTGCAGCTACTGTCACAGTAGAAGATAAAACTGGTCGTGTTTACACAGATCCTTCTCATCTTCCAGTTAATGTAGGAGCTAATTATTTCACTGTTAAAAGTACAGTTATTGATTCATTTGGTCGTACAGTAACCTTGACTTATCGTATTAATGTCCACCGTCGGCAAAATGACGAAGTCTATTATAATGAACTTTACCGCGACCAATATCACTATTCTGTAAAAGACGGCTGGGCTAATGATCCTAATGGCTTGGTTTATTACAATGGTGTTTATCATCTCTTCCATCAATTTTACGATGATACGAAATGGGGCCCTATGCACTGGGCGCACGCGACTAGTACGGATTTGATTCACTGGAAAGAAGAGCCAATTGCTTTTTACCCAGATTCAAACGGCTACATGTTCTCGGGCTGTGTAGTGGTTGACGAACATAACAGTTCAGGCTTATTTAAGACGGCTAAGGGTGGTTTAGTTGCGATTATCACAGCTAATGGAAATGGACAGCGCATGGAACTTGCCTATAGTGAAGATGAAGGCAAGACTTGGCAGAAATATGACAGGATTGTAGCCGATTGGTCAAATGACCCATTGCAAAATCAGGATTTTCGTGATCCAAAAGTTTTTCACTGGAATAACCAATGGTTCATGGTACTAGCAGGGGGTCCGCTTCGCATTTATTCTTCTAACAATTTGAAAGATTGGAAAGTGGAGTCTACTTATCCTGATCTTCATACAGAATGTCCAGATATGTATCCAATTGTTGCTAATGATGGTGTGCTTAAATGGGTGTTGTCTCGCGGCGGTCGTTTTTACAAGGTTGGTGATTTCAAACAAGTAGATGGTAAATGGACCTTTATAGCAGATGATGCTTATAAAGATAAGGATCAGGTCATGAACTTCGGTAAAGATTCTTATGCCGCCATGACCTACTATGTACACGATTTTGGTACAGAAACCCGACCAACCATTCCCAAATTAACAGAAGTCAACTGGATGAACACCTGGGAAGATTATTGTAATCTTGTAGCAGATACAGTTGGACAGGACTTTAACGGTACGTTTAATTTAAACCTTGATCTTGGCCTTATCAATGAAAACGGTCAGTACATCTTGACGCAAACGCCTGTTAAGGCCTATGATAGTCTTCGTGATGTGAATACTGCCTTGCATTTCAAAGATGTGACAGTAGACGCTAATAATACTCTTTTGAAGGACTTCAAAGGAGACAGTTATGAAATTGTTTCTCATTTCCGACCAGATGAGAAGACCACAAAAGTAGGCTTCAATCTTCGTGTTGGCAATGGTCAAGCAACGAAAGTGATTTACGACTTGCAGACAGAAACCTTGTCTATTGACCGTAGTCAGTCGGGTACTATCTTATCTGCAGCTTTTGCAAAAGTTAATAGTCAGCATGTGACTAAAAATGCAGATGGCTCCATTGATTTGCATATTTATGTTGATCGTGCCAGTGTTGAAGTCTTTTCCAAAAATAATACAGTGGCTGGTGCTAATCAAATTTTTCCTAATCCAGAAGCTGTAGGTGCCAGTATTATTGTAGAAGGCGGCAAAGCTCAAGCAGATATCTCTGTTTATCAAATGAAAACGATTTGGACAGATAAGAAAGATACGGCAAAACCGGTGGCTATGAACACAACAACTGCGAAAGAGCTAGCCCTTCAAGTTGGTCAAAGTCAGGATCTGCAAGTCTATCTGGCACCAGCAAGTGTTAGGCAAGATGTGGAATGGACGATCAGTGATCCAAGTCTTGTTAGGACAAGTCAAAAAGGTAATGTTCTTCATTTGACCGCTGTGAAAAAAGGAAAGCTTACCATTACAGCAATTTCTAAAGAAAACCCAAGTCTCAGTAAAACCTTTACAATCAGTATCACCTTAAATAATTTCAAGACTAACCTCAAAGGTTTGCAGTCTGTTACTGGTAAGTGGTATGTTGATGATGAAACGCTCTATGATAGTAATACAAGTTCGAATGATTACTATATGGCTTCTCAAAAACCGGGTTTCAAAGAATATGATTACGATATTGATCTCAAATATCAACGTGGTTTAATTAATCTTTTTGTTGCTTCTGGCAATATTGATCCGAGTCAAGCATATTCTGTACAATTTGGTGACAGTGAGACTGTTCGGCTTTACCGTTTTGCTGGTGATACTATTGCAGAAGCTAATATGGGTAAACGAATCAATGATGATCAATACCACCATATTAAAGTCACAAAAACAAAAAATAGTATAATCATATCAGTAGATGGTCAAGAAGTGATGAGTCATAACTTTGATCAGGTGGACTCATACTTTAATGATGCTTATGTAGGTCTCGGTTTGTGGGACGGAGCTGTTGAATTCCAAAACTTCTTTGTAACAGATCATGCGACTACTCCCAAACCAGATTCTGATCCGACACCGCAACCAGATGCACCAGAAGCATTGGCTCAAGAAAGGGAATTGATTGACCCTGCAACTGGCGTCCGTGTCATTCTTCAAAAAGGGGAGCTAGCTTCTATCGTTAGAGTAAAGGTCAGCCATATCGAAACGAATGATGCTCATACACCAGCTGTTCTAAATGCAAAAGACTATGATCTCTTCAATATCACACCTATTGATAAAAATGAGAAAGTTGTTGCTATTACGAAACCAGCGACAGTCTTATTGCCAATTGATGCTGGAAAAGTGGTAGATAAAGTGGTGTATTTACCAAATACGGACAAAGAAGAAAACCTTCCATTTACGATTGTGAGTTTGACAGATAGCAATGGTAAGAAGCAAAGTTATGTTCGCTTTACAGCAGAACACTTTAGTGAATACGGCTTAGTCTATCAAGCAGAAAATCAAACAAACCTTAAGAGTAAAGAAAAGCAAGACAATGTTGCTATTTCTTATCCATTAAATTTAGAACAAGAAGTTAAGGTTTCATCTATTTCACGAAAATATGCTGCAAATAAGACAGCAGATGTCAATAGTGTTCAACAAACAGAACCTTCAGTAATGAGTTCTTCACCTAAAGCAACGCTGCCAGATACTGGTGATCATAAGACAGATTTAAGTCAATTAGGAGTGTTGGCAATGATTGGCTCATTTCTTGTAGAAATAGCTGGCTATTTCAAAAAACGCAAGGATTGA","4.90","-46.62","158664","MEEETVCKNWFMRKSGKSWIFGCAVFFVLGLATALPVAAEEISQTTAADTAVTEVRTEDSSQTSSQETAVTETTQSEGTASKQLTTPAVADQTTEPTDNEPISSSDGASSPYQVTDTTEPQQTLTPADSEPQAKADVQQAAAPKKEEINPVTNLEDMSHDTNGTWEVREDGIHSNAIGKGDSFLYSQSSGKNFVYATDVTFKQNSGAAALVFRSNNDSNNKNMYAVNVDIGGHKAKFWRWVDNKDIQLIDERDVVPTADNRYTLKVVAVNNWISYYVNDILMASTGDYVLQKADKGQNTVIPEGHFGLLNWNGDMVFQNTKFALLDDTTAPLIDNITVRSDRGNVEKQGQFFSEEPLHIQYVSNDASQVSLDIAKHNPAATVTVEDKTGRVYTDPSHLPVNVGANYFTVKSTVIDSFGRTVTLTYRINVHRRQNDEVYYNELYRDQYHYSVKDGWANDPNGLVYYNGVYHLFHQFYDDTKWGPMHWAHATSTDLIHWKEEPIAFYPDSNGYMFSGCVVVDEHNSSGLFKTAKGGLVAIITANGNGQRMELAYSEDEGKTWQKYDRIVADWSNDPLQNQDFRDPKVFHWNNQWFMVLAGGPLRIYSSNNLKDWKVESTYPDLHTECPDMYPIVANDGVLKWVLSRGGRFYKVGDFKQVDGKWTFIADDAYKDKDQVMNFGKDSYAAMTYYVHDFGTETRPTIPKLTEVNWMNTWEDYCNLVADTVGQDFNGTFNLNLDLGLINENGQYILTQTPVKAYDSLRDVNTALHFKDVTVDANNTLLKDFKGDSYEIVSHFRPDEKTTKVGFNLRVGNGQATKVIYDLQTETLSIDRSQSGTILSAAFAKVNSQHVTKNADGSIDLHIYVDRASVEVFSKNNTVAGANQIFPNPEAVGASIIVEGGKAQADISVYQMKTIWTDKKDTAKPVAMNTTTAKELALQVGQSQDLQVYLAPASVRQDVEWTISDPSLVRTSQKGNVLHLTAVKKGKLTITAISKENPSLSKTFTISITLNNFKTNLKGLQSVTGKWYVDDETLYDSNTSSNDYYMASQKPGFKEYDYDIDLKYQRGLINLFVASGNIDPSQAYSVQFGDSETVRLYRFAGDTIAEANMGKRINDDQYHHIKVTKTKNSIIISVDGQEVMSHNFDQVDSYFNDAYVGLGLWDGAVEFQNFFVTDHATTPKPDSDPTPQPDAPEALAQERELIDPATGVRVILQKGELASIVRVKVSHIETNDAHTPAVLNAKDYDLFNITPIDKNEKVVAITKPATVLLPIDAGKVVDKVVYLPNTDKEENLPFTIVSLTDSNGKKQSYVRFTAEHFSEYGLVYQAENQTNLKSKEKQDNVAISYPLNLEQEVKVSSISRKYAANKTADVNSVQQTEPSVMSSSPKATLPDTGDHKTDLSQLGVLAMIGSFLVEIAGYFKKRKD","81844","For other 'fru' genes see SMu0071 (fruB); SMu0793 (fruR);SMu0794 (fruB) and SMu0795 (fruA). ","fructan hydrolase; exo-beta-D-fructosidase","Extracellular, Periplasm, Cellwall","This sequence has been previously published in GenBank as FRUA_STRMU (gi2500931, gi477562, gi153634). Residues 435-915 are 34% similar to residues 2-489 of the B.subtilis levanase (gi1334249).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1691 (4e-24).","

InterPro
IPR001362
Family

Glycoside hydrolase, family 32
SM00640	$\"[448-876]T$	Glyco_32
PS00609	$\"[448-461]N$	GLYCOSYL_HYDROL_F32

InterPro
IPR001899
Domain

Surface protein from Gram-positive cocci, anchor region
PF00746	$\"[1380-1421]T$	Gram_pos_anchor

InterPro
IPR003343
Domain

Bacterial Ig-like, group 2
PF02368	$\"[924-1003]T$	Big_2
SM00635	$\"[924-1003]T$	BID_2

InterPro
IPR008964
Domain

Invasin/intimin cell-adhesion
SSF49373	$\"[913-1008]T$	Invasin_intimin

InterPro
IPR013148
Domain

Glycosyl hydrolases family 32, N-terminal
PF00251	$\"[448-753]T$	Glyco_hydro_32N

InterPro
IPR013189
Domain

Glycosyl hydrolase family 32, C-terminal
PF08244	$\"[795-876]T$	Glyco_hydro_32C

noIPR
unintegrated

unintegrated
G3DSA:2.60.120.560	$\"[758-916]T$	G3DSA:2.60.120.560
SSF75005	$\"[443-753]T$	SSF75005

","BeTs to 3 clades of COG1621COG name: Beta-fructosidases (levanase/invertase)Functional Class: GThe phylogenetic pattern of COG1621 is ----y-v--B-----------Number of proteins in this genome belonging to this COG is 3","***** IPB001362 (Glycoside hydrolase family 32) with a combined E-value of 6.9e-13. IPB001362 447-472","Residues 651-829 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN PRECURSOR) protein domain (PD000903) which is seen in FRUA_STRMU.Residues 45-150 are 34% similar to a (Y51B11A.1) protein domain (PD326944) which is seen in Q9N4S7_CAEEL.Residues 95-161 are identical to a (BETA-FRUCTOSIDASE PRECURSOR FRUCTANASE) protein domain (PD097545) which is seen in FRUA_STRMU.Residues 1-94 are 86% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002249) which is seen in FRUA_STRMU.Residues 320-441 are identical to a (BETA-FRUCTOSIDASE PRECURSOR FRUCTANASE) protein domain (PD136431) which is seen in FRUA_STRMU.Residues 578-618 are 57% similar to a (FRUCTOFURANOSIDASE GLYCOSIDASE) protein domain (PD387539) which is seen in O02490_TRIFO.Residues 579-638 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN) protein domain (PD186044) which is seen in FRUA_STRMU.Residues 442-486 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN PRECURSOR) protein domain (PD186045) which is seen in FRUA_STRMU.Residues 162-319 are 99% similar to a (GLYCOSIDASE HYDROLASE ENDO-LEVANASE) protein domain (PD016576) which is seen in FRUA_STRMU.Residues 830-912 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN) protein domain (PD002161) which is seen in FRUA_STRMU.Residues 487-563 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN SIGNAL) protein domain (PD336564) which is seen in FRUA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 14:32:45 2006","Wed Dec 12 12:47:35 2001","Wed Sep 27 14:32:45 2006","Thu Apr 4 10:30:42 2002","Wed Dec 12 12:47:35 2001","Wed Dec 12 12:47:35 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0070 is paralogously related (blast p-value < 1e-3) to SMu1678, a predicted invertase, SMu0071, a predicted fructosidase, and to SMu1947, SMu1843, and SMu0827.","Wed Dec 12 12:59:00 2001","","No significant hits to the NCBI PDB database.","SMU.78","","Residues 448 to 880 (E-value = 1.7e-29) place SMu0070 in the Glyco_hydro_32 family which is described as Glycosyl hydrolases family 32 (PF00251)Residues 924 to 1003 (E-value = 6.2e-18) place SMu0070 in the Big_2 family which is described as Bacterial Ig-like domain (group 2) (PF02368)","Wed Sep 27 14:32:45 2006","24378602",""," Zeng L, Wen ZT, Burne RA,A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177Wen ZT, Burne RA.Analysis of cis- and trans-acting factors involved in regulation of the Streptococcus mutans fructanase gene (fruA).J Bacteriol. 2002 Jan;184(1):126-33.PMID: 11741852Burne,R.A. and Penders,J.E.Characterization of the Streptococcus mutans GS-5 fruA geneencoding exo-beta-D-fructosidaseInfect. Immun. 60 (11), 4621-4632 (1992)PubMed: 1398976Jayaraman,G.C., Penders,J.E. and Burne,R.A.Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK genes and regulation of expression in response to heat shock and environmental acidificationMol. Microbiol. 25 (2), 329-341 (1997)PubMed: 9282745Burne,R.A., Wen,Z.T., Chen,Y.Y. and Penders,J.E.Regulation of expression of the fructan hydrolase gene ofstreptococcus mutans GS-5 by induction and carbon cataboliterepressionJ. Bacteriol. 181 (9), 2863-2871 (1999)PubMed: 10217779Sato,Y. and Kuramitsu,H.K.Sequence analysis of the Streptococcus mutans scrB geneInfect. Immun. 56, 1956-1960 (1988)PubMed: 3397182Sato,Y., Poy,F., Jacobson,G.R. and Kuramitsu,H.K.Characterization and sequence analysis of the scrA gene encodingenzyme IIScr of the Streptococcus mutansphosphoenolpyruvate-dependent sucrose phosphotransferase systemJ. Bacteriol. 171 (1), 263-271 (1989)PubMed: 2536656","Martin,I., Debarbouille,M., Ferrari,E., Klier,A. and Rapoport,G.Characterization of the levanase gene of Bacillus subtilis whichshows homology to yeast invertaseMol. Gen. Genet. 208 (1-2), 177-184 (1987)PubMed: 3112519","Sat Oct 26 16:52:33 2002","Thu Apr 4 10:30:42 2002","1","","","SMU.78","" "SMu0071","81918","83477","1560","ATGCTAAAGAAAAAATTAGTTTGTTTATTAATCGGTTTAATTGCTTTTCTTGGCTCCCTTAAAATTTACGCTGGAAGCAGCGAAAGTGCTGAGTATCAGCAAACCAATCATTATAATACACCTAAAGGATTTATGAATGATATTCAGACGATTTTTAAGGGGAGTGATGGTTACTACCATATGTATTATTTGTTAAATAGTAACTATAAATTGGCAAATGATGGAACAGAATGGTACCATGTGAGAACTAAAGATTGGGAGCATTTTGAAAATTTAGGAGTAGCTATTCCTAAATTTGTTAATGGTTGGTCAGCAGTAGCAACAGGGTCAATTTTTCAAAATAGTAATCAATTTTTCAAAGATTTACCTACCAGTGCGATTGTAGCCTACTTTACCAGCTATACTGATACAGGTCAACATCAATATGTCGCTTATTCGTTAGATAATGGCAGCAGCTACCAGCCTTACAATAATGGTAAGCCAGTTATGATTTCACAAACAAAAGAGCAAAATGCGCGAGATCCTTACATTTGGTATGATTCTAATTCCAAAAGGTTAATGATGTACCTAGCTGAGGGTGATAAAATTGGGATCTATGCTAGTTCAGATGGGAAAAATTGGGCTTATCAAGGAGCGACTGTCCTCAATCAATATACCTTAGGGGGAAAAGACTTAGGTCTTGTGGAATGCCCAAATTTAAAAACTTTTTATGATTCTGCCACGAATACGACGAAACATGTTCTCTTTTTTGGTGCAAATGGTTACCAATATGGTTCGACGACAGGAACTTATTATATGATTGGTCATTTAGATACTCAAGGAAATTTTGTGCCAGAGCAAAATGCAGAACGTTTGGATCAAGGCTCAGACTATTACGGTGCCAACTTTTATCAAGAAAGCGATTGCGTCGTTAAGAGTATAGCTTGGATGGGGAATTGGGATTACCTGCAAGGGCAGATTCTTGATGATCAAGGCCAAGAATCCAAACATTTAGGTTCCGTTAGTTCAGCTAGAGATATTACAATGGTTAAAAGAGATGATAAATATGTTTTGGAGTCTTACCTTAAAAATAACAACTCTAGGACAAACACTGTTAGCTACCAAAGCAACGCTGATACGGCAAAACTTGCTGATGATGGCTATCATAAAACTTTATTATCGGTATCAAGATGGCATTCACAGGAACTATCTTTGAAATTTCAAGCTAATGCTGCAACCCTAAACGGACATATTCGTTTAATTTTCAAACAAGCAGATGCCCAAGTGTCTCTTGACTACAATACTGATAATGGTTACTATGAGGTAAAAAGAACCAGTTCTAAAATAATTGGCAGCCAAAAAGTGAATTATGAACGCTCATATGTTGTTGATAGCCACTGGAATGGGCAAAAGGAACTTAATATTTATCTCGTAGCTGACAAAAGCAGCTTGGAATTTGCTCTGCCGAATGGTCAGACCTACTCCATGGTCAAATTGTCCACTGCCAGTGATATGGATATCGTTATTGAGACTAGTGGAAGCAACCGTTTACAGGCAGATTTAGCTAATTTGGAAACGTAA","6.10","-6.23","58545","MLKKKLVCLLIGLIAFLGSLKIYAGSSESAEYQQTNHYNTPKGFMNDIQTIFKGSDGYYHMYYLLNSNYKLANDGTEWYHVRTKDWEHFENLGVAIPKFVNGWSAVATGSIFQNSNQFFKDLPTSAIVAYFTSYTDTGQHQYVAYSLDNGSSYQPYNNGKPVMISQTKEQNARDPYIWYDSNSKRLMMYLAEGDKIGIYASSDGKNWAYQGATVLNQYTLGGKDLGLVECPNLKTFYDSATNTTKHVLFFGANGYQYGSTTGTYYMIGHLDTQGNFVPEQNAERLDQGSDYYGANFYQESDCVVKSIAWMGNWDYLQGQILDDQGQESKHLGSVSSARDITMVKRDDKYVLESYLKNNNSRTNTVSYQSNADTAKLADDGYHKTLLSVSRWHSQELSLKFQANAATLNGHIRLIFKQADAQVSLDYNTDNGYYEVKRTSSKIIGSQKVNYERSYVVDSHWNGQKELNIYLVADKSSLEFALPNGQTYSMVKLSTASDMDIVIETSGSNRLQADLANLET","83474","For other 'fru' genes see SMu0070 (fruA); SMu0793 (fruR);SMu0794 (fruB) and SMu0795 (fruA). ","fructan hydrolase; exo-beta-D-fructosidase","Extracellular, Cellwall","This sequence has been previously published in GenBank as FRUB_STRMU (gi|4733889); see also gi|153634, gi|2500931, gi|477562. Residues 26-506 are 27% similar to the levanase from B.subtilis (gi|16080499).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1691 (1e-04).","

InterPro
IPR001362
Family

Glycoside hydrolase, family 32
SM00640	$\"[37-484]T$	Glyco_32

InterPro
IPR008985
Domain

Concanavalin A-like lectin/glucanase
SSF49899	$\"[361-518]T$	ConA_like_lec_gl

InterPro
IPR013148
Domain

Glycosyl hydrolases family 32, N-terminal
PF00251	$\"[37-353]T$	Glyco_hydro_32N

noIPR
unintegrated

unintegrated
SSF75005	$\"[32-353]T$	SSF75005

","BeTs to 3 clades of COG1621COG name: Beta-fructosidases (levanase/invertase)Functional Class: GThe phylogenetic pattern of COG1621 is ----y-v--B-----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 1-82 are identical to a (FRUB) protein domain (PD391145) which is seen in Q9X991_STRMU.Residues 83-163 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN SIGNAL) protein domain (PD336564) which is seen in Q9X991_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:56:39 2002","Wed Dec 12 13:07:06 2001","Wed Jan 9 14:53:34 2002","Thu Apr 4 10:31:23 2002","","Wed Dec 12 13:07:06 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0071 is paralogously related (blast p-value < 1e-3) to SMu0070, a predicted FruA protein, and to SMu1678, a predicted invertase.","Wed Dec 12 13:16:02 2001","","No significant hits to the NCBI PDB database.","SMU.79","","Residues 37 to 484 (E-value = 2.7e-10) place SMu0071 in the Glyco_hydro_32 family which is described as Glycosyl hydrolases family 32 (PF00251)","Wed Dec 12 13:07:06 2001","24378603","","Burne,R.A. and Penders,J.E.Characterization of the Streptococcus mutans GS-5 fruA geneencoding exo-beta-D-fructosidaseInfect. Immun. 60 (11), 4621-4632 (1992)PubMed: 1398976Jayaraman,G.C., Penders,J.E. and Burne,R.A.Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK genes and regulation of expression in response to heat shock and environmental acidificationMol. Microbiol. 25 (2), 329-341 (1997)PubMed: 9282745Burne,R.A., Wen,Z.T., Chen,Y.Y. and Penders,J.E.Regulation of expression of the fructan hydrolase gene ofstreptococcus mutans GS-5 by induction and carbon cataboliterepressionJ. Bacteriol. 181 (9), 2863-2871 (1999)PubMed: 10217779","","Thu Apr 4 10:33:04 2002","","1","","","SMU.79","" "SMu0072","83652","84686","1035","GTGATTACCCAGCGTCAAAAGGATATTCTCAATTTGATTGTTGAGCTTTTTACTAAGACACATGAGCCCATTGGGTCTAAAACACTCCAGAATTCAATTGCATCAAGCAGTGCTACCATCAGAAATGATATGGCAGCTTTAGAAAAATTAGGACTCTTAGAGAAGGCGCACACCTCCAGCGGTCGTTTGCCCAGTCAAGAAGGCTTTCGTTATTTTGTTGAACATTCTTTGAATCCAGACAGTTTGGACGAACAGGATGTTTATCAAGTCATTAAGGCATTTGATTTTGAAGCTTTTCGTTTAGGGGATCTTCTACAAAGAGCCAGTGATGTTTTGGCGAATCTGACTGGCTATACAGCACTGATTTTGGATGTGGAGCCTAAAAAGCAACGTTTGACTACTTTTGATATTGTTAAGCTTAGCAATCATGATGCTTTAGCTGTTTTGACTCTAGATGAAGCCAGTCCTGTAACGGTGCAATTTGCCATTCCCAAAAATTTTTTGGACAGCGATTTAATGACAGTGGCTAAAATAGCTCGGGAACGTTTTTTAAATCAAACGGTTCTAGATATTCATTATCGTTTACGAACGGAGCTGCCGCAGATTATTCAGAAATATTTTCCACGAACGGACAATGTTTTAGATCTATTTGATCACATTTTTAATCCCATTTTTCAAGAAGAAGTTTTTATCTCTGGTAAAATTAAAACTTTGGAATTTGCTGGGCTTAACACTTATCAATTCTTGGAAAATCTACAATCAGTAGCTCTTGAAATTCGTCAAAGCCTACCTGAAGATGAACTTCATCGAGTTCAAGTTGCTGATAGTAAAGAAAAGAGTTTAGCAGATTTAACCGTTATCAGTCAGAAATTTCTCATTCCTTATAGAGGGTTTGGAATTTTGACCGTAATTGGTCCAGTAGATTTGGATTATCAAAGAACAATAAGCTTGATTAATGTTATTAGTCGTGTTTTAGCTGTAAAATTAGGCGATTTCTATCGTTATCTCAATAGCAATCATTACGAGGTTCATTAG","5.70","-6.81","39185","MITQRQKDILNLIVELFTKTHEPIGSKTLQNSIASSSATIRNDMAALEKLGLLEKAHTSSGRLPSQEGFRYFVEHSLNPDSLDEQDVYQVIKAFDFEAFRLGDLLQRASDVLANLTGYTALILDVEPKKQRLTTFDIVKLSNHDALAVLTLDEASPVTVQFAIPKNFLDSDLMTVAKIARERFLNQTVLDIHYRLRTELPQIIQKYFPRTDNVLDLFDHIFNPIFQEEVFISGKIKTLEFAGLNTYQFLENLQSVALEIRQSLPEDELHRVQVADSKEKSLADLTVISQKFLIPYRGFGILTVIGPVDLDYQRTISLINVISRVLAVKLGDFYRYLNSNHYEVH","84683","","heat-inducible transcription repressor","Cytoplasm","This sequence has been previously published in GenBank as HRCA_STRMU (gi10720393, gi2145131). Residues 1-344 are 65% similar to the predicted HrcA from S.pyogenes (gi15675608).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0095 (1e-135).","

InterPro
IPR002571
Family

Negative regulator of class I heat shock protein
PF01628	$\"[101-315]T$	HrcA
TIGR00331	$\"[3-329]T$	hrcA: heat-inducible transcription represso

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[2-83]T$	no description

","BeTs to 7 clades of COG1420COG name: Transcriptional regulators of heat shock genes HrcAFunctional Class: KThe phylogenetic pattern of COG1420 is ------vc-br-ujgp--in-Number of proteins in this genome belonging to this COG is 1","***** IPB002571 (Negative regulator of class I heat shock protein) with a combined E-value of 5.9e-44. IPB002571A 20-29 IPB002571B 36-74 IPB002571C 301-319","Residues 4-149 are 90% similar to a (REPRESSOR TRANSCRIPTION HEAT-INDUCIBLE) protein domain (PD003513) which is seen in HRCA_STRMU.Residues 189-343 are 98% similar to a (TRANSCRIPTION REPRESSOR HEAT-INDUCIBLE) protein domain (PD036572) which is seen in HRCA_STRMU.Residues 68-148 are 56% similar to a (TRANSCRIPTION REPRESSOR HEAT-INDUCIBLE) protein domain (PD391516) which is seen in HRCA_STRPN.Residues 4-65 are 64% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD002333) which is seen in HRCA_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 10:35:18 2002","Fri Sep 1 18:14:35 2006","Fri Sep 1 18:14:35 2006","Fri Sep 1 18:14:35 2006","Wed Dec 12 14:00:24 2001","Wed Dec 12 14:00:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0072 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 14:06:31 2001","","No significant hits to the NCBI PDB database.","SMU.80","","Residues 101 to 315 (E-value = 4e-84) place SMu0072 in the HrcA family which is described as HrcA protein C terminal domain (PF01628)","Wed Dec 12 14:00:24 2001","24378604","","Burne,R.A. and Penders,J.E.Characterization of the Streptococcus mutans GS-5 fruA geneencoding exo-beta-D-fructosidaseInfect. Immun. 60 (11), 4621-4632 (1992)PubMed: 93014178Jayaraman,G.C., Penders,J.E. and Burne,R.A.Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK genes and regulation of expression in response to heat shock and environmental acidificationMol. Microbiol. 25 (2), 329-341 (1997)PubMed: 97426041Burne,R.A., Wen,Z.T., Chen,Y.Y. and Penders,J.E.Regulation of expression of the fructan hydrolase gene ofstreptococcus mutans GS-5 by induction and carbon cataboliterepressionJ. Bacteriol. 181 (9), 2863-2871 (1999)PubMed: 99235768Lemos JA, Chen YY, Burne RA. Genetic and physiologic analysis of the groE operon and role of the HrcA repressor in stress gene regulation and acid tolerance in Streptococcus mutans.J Bacteriol. 2001 Oct;183(20):6074-84.PMID: 11567008 ","","Sat Oct 26 17:14:35 2002","","1","","","SMU.80","228" "SMu0073","84729","85268","540","TTGTCGAAAAAAGATAAAAAAGAAGAGATCAAGGAAGAAGTAGAAGCAACTGAGCCTACAACTGAAGAGTCCGTAGAAGAAGTCGCTGAAGAAACTTCTGAAAACAAGGAGTTGCAAGAAGCACTTGAGCGAGCTGAAGATTTTGAAAATAAATATTTGCGTGCTCATGCTGAAATGCAAAACATTCAGCGTCGCGCTAATGAAGAGCGACAAAGTTTGCAGAGGTATCGCTCTCAGGATTTAGCTAAAGCTATCTTGCCTTCACTTGATAATCTTGAACGTGCTCTTGCTGTTGAAGGTTTGACAGATGATGTCAAGAAAGGATTGGAAATGGTTCAGGAGAGTCTCATTCAGGCTTTGAAAGAAGAAGGTGTGGAAGAGGTTGAACTTGAGAATTTTGATCCTAATTTGCATATGGCTGTGCAGACTCTTGATGCAGATGATGACCATCCAGCAGATAGTATTGCACAAGTCCTTCAAAAAGGGTATCAGCTCCATGAACGTTTGTTAAGACCGGCAATGGTAGTTGTCTATAACTAA","4.30","-21.00","20542","MSKKDKKEEIKEEVEATEPTTEESVEEVAEETSENKELQEALERAEDFENKYLRAHAEMQNIQRRANEERQSLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMVQESLIQALKEEGVEEVELENFDPNLHMAVQTLDADDDHPADSIAQVLQKGYQLHERLLRPAMVVVYN","85265","","co-chaperone protein GrpE","Cytoplasm","This sequence has been previously published in GenBank as GRPE_STRMU (gi2495090, gi2145132). Residues 35-179 are 81% similar to residues 35-180 0f GRPE_STRMU. Residues 37-179 are 79% similar to gi15675607 of S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0096 (4e-60).","

InterPro
IPR000740
Family

GrpE nucleotide exchange factor
PR00773	$\"[53-69]T$ $\"[81-96]T$ $\"[130-145]T$ $\"[158-177]T$	GRPEPROTEIN
PTHR21237	$\"[8-177]T$	GRPE PROTEIN
PF01025	$\"[5-179]T$	GrpE
PS01071	$\"[133-177]T$	GRPE

InterPro
IPR009012
Domain

GrpE nucleotide exchange factor, head
G3DSA:2.30.22.10	$\"[124-178]T$	no description

InterPro
IPR013805
Domain

GrpE nucleotide exchange factor, coiled-coil
G3DSA:3.90.20.20	$\"[24-122]T$	no description

noIPR
unintegrated

unintegrated
PTHR21237:SF3	$\"[8-177]T$	GRPE PROTEIN (HSP-70 COFACTOR)

","BeTs to 14 clades of COG0576COG name: Molecular chaperone GrpE (heat shock protein)Functional Class: OThe phylogenetic pattern of COG0576 is --t-yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000740 (GrpE protein) with a combined E-value of 4.3e-27. IPB000740A 54-65 IPB000740B 122-141 IPB000740C 153-177 IPB000740A 43-54","Residues 37-104 are 38% similar to a (CHAPERONE HEAT SHOCK TRANSIT) protein domain (PD411027) which is seen in Q9CNU1_PASMU.Residues 35-96 are 74% similar to a (SHOCK HEAT CHAPERONE COFACTOR) protein domain (PD001891) which is seen in GRPE_STRMU.Residues 103-177 are 84% similar to a (SHOCK CHAPERONE HEAT COFACTOR) protein domain (PD002432) which is seen in GRPE_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Apr 24 16:48:51 2002","Mon Jul 24 14:52:20 2006","Mon Jul 24 14:51:21 2006","Wed Apr 24 16:48:51 2002","Fri Dec 14 09:20:01 2001","Fri Dec 14 09:20:01 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0073 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 09:20:01 2001","Mon Jul 24 14:51:21 2006","pdb1DKGA Chain A, Crystal Structure Of The Nucleotide Exchang... 70 2e-013","SMU.81","","Residues 12 to 179 (E-value = 1e-59) place SMu0073 in the GrpE family which is described as GrpE (PF01025)","Fri Dec 14 09:20:01 2001","24378605","","Burne,R.A. and Penders,J.E.Characterization of the Streptococcus mutans GS-5 fruA geneencoding exo-beta-D-fructosidaseInfect. Immun. 60 (11), 4621-4632 (1992)PubMed: 93014178Jayaraman,G.C., Penders,J.E. and Burne,R.A.Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK genes and regulation of expression in response to heat shock and environmental acidificationMol. Microbiol. 25 (2), 329-341 (1997)PubMed: 97426041Burne,R.A., Wen,Z.T., Chen,Y.Y. and Penders,J.E.Regulation of expression of the fructan hydrolase gene ofstreptococcus mutans GS-5 by induction and carbon cataboliterepressionJ. Bacteriol. 181 (9), 2863-2871 (1999)PubMed: 99235768","Mehl AF, Heskett LD, Neal KM.A GrpE mutant containing the NH(2)-terminal \"tail\" region is able to displace bound polypeptide substrate from DnaK.Biochem Biophys Res Commun. 2001 Mar 30;282(2):562-9.PMID: 11401497Jurgen B, Hanschke R, Sarvas M, Hecker M, Schweder T.Proteome and transcriptome based analysis of Bacillus subtilis cells overproducing an insoluble heterologous protein.Appl Microbiol Biotechnol. 2001 Apr;55(3):326-32.PMID: 11341315 ","Wed Apr 24 16:48:51 2002","Mon Jul 24 15:04:33 2006","1","","","SMU.81","619" "SMu0074","85642","87480","1839","ATGTCTAAAATTATTGGTATTGATTTAGGTACAACAAACTCAGCAGTTGCAGTTCTTGAAGGAACTGAAAGCAAAATTATCGCTAATCCCGAAGGAAACCGTACAACTCCTTCTGTAGTTTCATTTAAAAATGGTGAAATCATCGTTGGTGATGCTGCTAAACGTCAAGCAGTGACTAATCCAGAAACAATTCTTTCCATCAAATCTAAGATGGGGACTTCTGAAAAAGTTTCAGCTAATGGCAAAGAGTATACGCCACAAGAAATCTCAGCTATGATTCTGCAATATTTGAAAGGTTATGCGGAAGATTACCTTGGTGAAAAAGTCGAAAAAGCCGTTATTACAGTTCCTGCTTACTTTAACGATGCACAACGTCAAGCAACTAAAGATGCTGGTAAAATCGCTGGTCTTGAAGTAGAACGTATTGTCAACGAACCAACAGCTGCAGCACTTGCTTATGGCCTTGACAAAACAGATAAGGATGAGAAAATTTTAGTCTTCGACCTTGGTGGTGGTACTTTTGACGTATCAATCCTTGAATTAGGTGACGGTGTCTTTGACGTTTTGGCAACTGCTGGAGATAATAAACTTGGTGGTGATAACTTTGACCAAAAAGTCATTGATTGGTTGGTTGAAGAATTCAAGAAAGAAAATGGTATTGATTTATCAACTGATAAGATGGCTCTTCAACGCTTGAAAGATGCTGCTGAAAAAGCTAAGAAAGATCTTTCAGGTGTAACATCAACACAAATCAGTTTACCTTTCATTACCGCTGGTGAAGCAGGACCCCTTCATTTAGAAACGAGCCTTTCTCGTGCTAAGTTTGATGATTTAACACGCGATCTAGTTGAACGTACTAAAACTCCTGTTCGTCAAGCCCTTTCAGATGCTGGTTTGTCATTGTCAGAAATTGATGAAGTTATCTTAGTCGGCGGTTCAACACGTATTCCAGCTGTTGTAGATGCTGTTAAAGCTGAAACTGGCAAAGAACCAAATAAATCAGTGAATCCAGATGAAGTTGTTGCTATGGGGGCTGCCATTCAAGGTGGTGTTATCACTGGTGATGTCAAAGATGTCGTTCTTCTTGACGTAACGCCATTGTCACTTGGTATCGAAACAATGGGTGGTGTCTTTACTAAACTCATTGATCGCAATACAACAATCCCAACTTCTAAATCACAAGTCTTCTCAACAGCTGCAGATAACCAACCAGCCGTTGATATCCATGTTCTCCAAGGGGAACGCCCAATGGCAGCGGACAATAAAACACTTGGCCGTTTCCAATTGACAGATATTCCAGCTGCGCCTCGTGGTGTGCCACAAATCGAAGTAACATTCGATATTGATAAGAACGGTATCGTGTCTGTTAAGGCTAAAGACCTTGGAACTCAAAAAGAACAAACAATCGTCATTCAATCTAACTCAGGTCTTACTGATGAAGAAATTGATAAAATGATGAAAGATGCTGAAGCAAATGCTGAAGCTGATGCTAAGCGTAAAGAAGAAGTTGATCTTAAGAACGAGGTTGATCAAGCTATCTTTACAACCGAAAAAACTATCAAAGAGACTGAAGGAAAAGGTTTCGATACTGAACGTGATGCCGCTCAGGCCGCTCTTGATGACTTGAAGAAAGCCCAAGAATCAGGTAACCTTGACGATATGAAGGCTAAACTTGAAGCACTTAATGAAAAAGCTCAAGCTCTTGCCATGAAACTTTATGAACAAGCTGCTGCCGCCCAACAAGCACAAGCAGGTCAAGAGGGAGCTCAATCATCTGATTCTGATTCATCAGACAAGGGCGGCGACGATGTTGTAGATGGAGAGTTTACGGAGAAATAA","4.40","-35.42","65277","MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPETILSIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEDYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGDNFDQKVIDWLVEEFKKENGIDLSTDKMALQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLETSLSRAKFDDLTRDLVERTKTPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVDAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGVPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDKMMKDAEANAEADAKRKEEVDLKNEVDQAIFTTEKTIKETEGKGFDTERDAAQAALDDLKKAQESGNLDDMKAKLEALNEKAQALAMKLYEQAAAAQQAQAGQEGAQSSDSDSSDKGGDDVVDGEFTEK","87477","For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0075 (dnaJ);SMu0745 (dnaG); SMu1091 (dnaE); SMu1745 (dnaI); SMu1746 (dnaB);SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC). ","chaperone protein, DnaK","Cytoplasm, Periplasm","This sequence has been previously published in GenBank as DNAK_STRMU (gi2495353, gi2145133). Residues 1-573 are 85% similar to DNAK_STRMU. Residues 1-573 are 85% similar to the dnaK from S.pneumoniae (gi15900431). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0097 (0.0).","

InterPro
IPR001023
Family

Heat shock protein Hsp70
PR00301	$\"[3-16]T$ $\"[31-43]T$ $\"[53-61]T$ $\"[112-132]T$ $\"[172-182]T$ $\"[304-320]T$ $\"[335-355]T$ $\"[358-377]T$ $\"[439-455]T$	HEATSHOCK70
PTHR19375	$\"[1-494]T$	Hsp70

InterPro
IPR012725
Family

Chaperone DnaK
TIGR02350	$\"[3-574]T$	prok_dnaK

InterPro
IPR013126
Family

Heat shock protein 70
PD000089	$\"[76-136]T$	Hsp70
PF00012	$\"[4-574]T$	HSP70
PS00297	$\"[7-14]T$	HSP70_1
PS00329	$\"[166-179]T$	HSP70_2
PS01036	$\"[307-321]T$	HSP70_3

noIPR
unintegrated

unintegrated
G3DSA:2.60.34.10	$\"[341-531]T$	G3DSA:2.60.34.10
G3DSA:3.30.420.40	$\"[4-184]T$	G3DSA:3.30.420.40
G3DSA:3.90.640.10	$\"[198-285]T$	G3DSA:3.90.640.10
PTHR19375:SF1	$\"[1-494]T$	PTHR19375:SF1
SSF100920	$\"[353-510]T$	SSF100920
SSF100934	$\"[504-582]T$	SSF100934
SSF53067	$\"[4-158]T$ $\"[160-353]T$	SSF53067

","BeTs to 14 clades of COG0443COG name: Molecular chaperones (HSP70/DnaK family)Functional Class: OThe phylogenetic pattern of COG0443 is --t-YQvCEbRHujgpOlinXNumber of proteins in this genome belonging to this COG is 1","***** IPB001023 (Heat shock protein hsp70) with a combined E-value of 3.7e-192. IPB001023A 5-37 IPB001023B 96-149 IPB001023C 164-199 IPB001023D 289-328 IPB001023E 358-406 IPB001023F 424-471***** IPB002821 (Hydantoinase/oxoprolinase) with a combined E-value of 1.8e-13. IPB002821A 3-16 IPB002821C 106-155","Residues 547-573 are 96% similar to a (SHOCK HEAT CHAPERONE ATP-BINDING) protein domain (PD410056) which is seen in DNAK_STRAG.Residues 303-367 are 48% similar to a (SHOCK HEAT SIMILAR FAMILY) protein domain (PD109123) which is seen in Q21383_CAEEL.Residues 4-80 are 64% similar to a (SHOCK HEAT CHAPERONE ATP-BINDING) protein domain (PD275452) which is seen in DNAK_MYCHY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Jul 9 10:15:31 2006","Sun Jul 9 10:15:31 2006","Sun Jul 9 10:15:31 2006","Thu Mar 28 10:20:46 2002","Fri Dec 14 09:32:46 2001","Fri Dec 14 09:32:46 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0074 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:05:56 2001","Sun Jul 9 10:15:31 2006","pdb1DKGD Chain D, Crystal Structure Of The Nucleotide Exchang... 387 2e-108pdb1HJOA Chain A, Heat-Shock 70kd Protein 42kd Atpase N-Termi... 319 6e-088pdb3HSC Heat-Shock Cognate 7okd Protein (44kd Atpase N-Ter... 317 3e-087","SMU.82","","Residues 2 to 357 (E-value = 1.4e-05) place SMu0074 in the MreB_Mbl family which is described as MreB/Mbl protein (PF06723)","Fri Dec 14 09:32:46 2001","24378606","","Jayaraman,G.C., Penders,J.E. and Burne,R.A.Transcriptional analysis of the Streptococcus mutans hrcA, grpE and dnaK genes and regulation of expression in response to heat shock and environmental acidificationMol. Microbiol. 25 (2), 329-341 (1997)PubMed: 9282745Burne,R.A. and Penders,J.E.Characterization of the Streptococcus mutans GS-5 fruA geneencoding exo-beta-D-fructosidaseInfect. Immun. 60 (11), 4621-4632 (1992)PubMed: 1398976Burne,R.A., Wen,Z.T., Chen,Y.Y. and Penders,J.E.Regulation of expression of the fructan hydrolase gene ofstreptococcus mutans GS-5 by induction and carbon cataboliterepressionJ. Bacteriol. 181 (9), 2863-2871 (1999)PubMed: 10217779","Swain JF, Sivendran R, Gierasch LM.Defining the structure of the substrate-free state of the DnaK molecular chaperone.Biochem Soc Symp. 2001;(68):69-82.PMID: 11573348","Thu Mar 28 10:20:46 2002","Fri Dec 14 10:05:56 2001","1","","","SMU.82","13" "SMu0075","88008","89141","1134","ATGAACAATCAAGAATATTATGATCGTCTTGGTGTCTCAAAGGACGCTTCACAAGACGAAATTAAAAAAGCCTATCGCAGGATGTCTAAAAAATATCATCCAGATATTAATAAAGAACCAGGTGCGGAGGAAAAATATAAGGAAATTCAAGAGGCTTATGATACACTAGGCGATGAACAAAAACGTGCTGCTTATGATCAGTACGGTCCAGCTGGAGCTAATGGCGGCTTTGGTGATGGTAGTGGTTTTAGTGGCTTTGATAGTTCGGGCTTTGGTGGTTTTGAAGATATCTTTTCAAGCTTCTTTGGCGGCGGAGCCTCTAGGAATCCTAATGCACCCCGTCAGGGTGATGATCTTCAATATCGTGTTAATTTACAATTTGAAGAAGCTGTTTTTGGAACAGAAAAAGAAGTGCACTATAATCGTGAAGCAAGCTGTCATACTTGTAATGGCTCTGGAGCTAAACCAGGAACTAGTCCTGTTACTTGTAGCAAATGTCATGGTTCAGGTGTTATCAATATGGATACCCAAACGCCACTTGGTATGATGCGTCGTCAAGTAACCTGTGATGTTTGTCATGGAACGGGCCAAGAAATTAAAGAGCCTTGTCCAACTTGTCATGGAACGGGTCATGAAAAGCAAAGCCATAAAGTTTCTGTCAAGATTCCTGCTGGTGTTGAAACAGGCCAGCAAATTCGGTTGGCAGGACAAGGGGAAGCTGGCTTTAATGGCGGCCCTTATGGTGACCTCTTTGTCATTATCAATGTCCTCAAGAGTGATAAATTCGAACGTGATGGTTCAACCATTTACTATAGTATGGACATTAATTTTGTTCAGGCTGCACTTGGTGATACTGTTGAAGTACCAACAGTTCATGGTAATGTTGAACTCGCTATTCCAGCAGGTACCCAGACAGGTAAGACATTCCGTCTCAAAGGTAAAGGAGCTCCGCGTTTGCGTGGAAATGGACAGGGAGATCAGCACGTTACTGTTAATGTTGTTACTCCAACAAAACTTAATGATGCCCAAAAAGAGGCCCTGCAAGATTTTGCTAAGGCTAGTGGTATAAATCCTGTTCATCCTAAGAAAAAAGGTTTCTTTAATAAAGTCAAGGACGCTTTTGATGAGATGTAG","6.70","-1.71","40846","MNNQEYYDRLGVSKDASQDEIKKAYRRMSKKYHPDINKEPGAEEKYKEIQEAYDTLGDEQKRAAYDQYGPAGANGGFGDGSGFSGFDSSGFGGFEDIFSSFFGGGASRNPNAPRQGDDLQYRVNLQFEEAVFGTEKEVHYNREASCHTCNGSGAKPGTSPVTCSKCHGSGVINMDTQTPLGMMRRQVTCDVCHGTGQEIKEPCPTCHGTGHEKQSHKVSVKIPAGVETGQQIRLAGQGEAGFNGGPYGDLFVIINVLKSDKFERDGSTIYYSMDINFVQAALGDTVEVPTVHGNVELAIPAGTQTGKTFRLKGKGAPRLRGNGQGDQHVTVNVVTPTKLNDAQKEALQDFAKASGINPVHPKKKGFFNKVKDAFDEM","89138","For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0074(dnaK);SMu0745 (dnaG); SMu1091 (dnaE); SMu1745 (dnaI); SMu1746(dnaB);SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC). ","co-chaperone protein DnaJ","Cytoplasm, Extracellular","Several matches in gapped BLAST to DnaJ proteins. Residues 1-377 are 76% similar to the protein from S.pyogenes (gi10566912) and the protein from S.pneumoniae (gi15675605).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0098 (1e-175).","

InterPro
IPR001305
Domain

DnaJ central region
PF00684	$\"[133-217]T$	DnaJ_CXXCXGXG
PS51188	$\"[133-215]T$	ZF_CR

InterPro
IPR001623
Domain

Heat shock protein DnaJ, N-terminal
PF00226	$\"[5-66]T$	DnaJ
SM00271	$\"[4-61]T$	DnaJ
PS00636	$\"[46-65]T$	DNAJ_1
PS50076	$\"[5-69]T$	DNAJ_2
SSF46565	$\"[1-120]T$	DnaJ_N

InterPro
IPR002939
Domain

Chaperone DnaJ, C-terminal
PF01556	$\"[230-351]T$	DnaJ_C

InterPro
IPR003095
Family

Heat shock protein DnaJ
PR00625	$\"[16-35]T$ $\"[46-66]T$ $\"[138-157]T$ $\"[163-173]T$ $\"[181-199]T$ $\"[201-216]T$ $\"[220-236]T$ $\"[266-283]T$	DNAJPROTEIN

InterPro
IPR008971
Domain

HSP40/DnaJ peptide-binding
SSF49493	$\"[111-260]T$ $\"[261-348]T$	HSP40_DnaJ_pep

InterPro
IPR012724
Family

Chaperone DnaJ
TIGR02349	$\"[5-354]T$	DnaJ_bact

InterPro
IPR015609
Family

Molecular chaperone, heat shock protein, Hsp40, DnaJ
PTHR11821	$\"[1-338]T$	Hsp40/DnaJ_Rel

noIPR
unintegrated

unintegrated
G3DSA:1.10.287.110	$\"[4-75]T$	G3DSA:1.10.287.110
G3DSA:2.10.230.10	$\"[133-215]T$	G3DSA:2.10.230.10
G3DSA:2.60.260.20	$\"[259-348]T$	G3DSA:2.60.260.20
PTHR11821:SF79	$\"[1-338]T$	PTHR11821:SF79
SSF57938	$\"[133-215]T$	SSF57938

","BeTs to 14 clades of COG0484COG name: Molecular chaperones, DnaJ family (contain C-terminal Zn finger domain)Functional Class: OThe phylogenetic pattern of COG0484 is --t-YQVCebRhUjGPOLinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001305 (DnaJ central domain (CXXCXGXG)) with a combined E-value of 1.6e-148. IPB001305A 5-37 IPB001305B 45-70 IPB001305C 115-166 IPB001305D 189-234 IPB001305E 244-283 IPB001305F 299-350 IPB001305F 222-273***** PR00625 (DnaJ protein family signature) with a combined E-value of 3.8e-74. PR00625A 16-35 PR00625B 46-66 PR00625C 138-157 PR00625D 163-173 PR00625E 181-199 PR00625F 201-216 PR00625G 220-236 PR00625H 266-283 PR00625C 181-200 PR00625C 195-214 PR00625C 155-174 PR00625D 189-199 PR00625D 203-213 PR00625D 146-156 PR00625E 195-213 PR00625E 155-173 PR00625F 161-176 PR00625F 187-202 PR00625G 297-313 PR00625H 116-133***** IPB001623 (DnaJ N-terminal domain) with a combined E-value of 3.1e-21. IPB001623A 21-35 IPB001623B 45-66","Residues 218-265 are 45% similar to a (REPEAT CHAPERONE DNAJ HOMOLOGUE) protein domain (PD243325) which is seen in P92424_PEA.Residues 266-347 are 73% similar to a (CHAPERONE HEAT SHOCK REPEAT) protein domain (PD001578) which is seen in DNAJ_LACLA.Residues 218-264 are 55% similar to a (CHAPERONE DNAJ2 SHOCK HEAT) protein domain (PD171562) which is seen in DNJ2_STRAL.Residues 1-68 are 85% similar to a (CHAPERONE HEAT SHOCK REPEAT REPLICATION METAL-BINDING) protein domain (PD000231) which is seen in Q9FAZ9_STRPY.Residues 265-348 are 88% similar to a (CHAPERONE SHOCK HEAT REPEAT) protein domain (PD341836) which is seen in Q9FAZ9_STRPY.Residues 218-264 are 89% similar to a (CHAPERONE REPEAT SHOCK HEAT) protein domain (PD404783) which is seen in Q9FAZ9_STRPY.Residues 133-214 are 82% similar to a (CHAPERONE REPEAT HEAT SHOCK REPLICATION ZINC) protein domain (PD000802) which is seen in Q9FAZ9_STRPY.Residues 220-264 are 64% similar to a (CHAPERONE HEAT SHOCK REPEAT REPLICATION ZINC) protein domain (PD149643) which is seen in Q9KD71_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 24 15:03:55 2006","Mon Jul 24 15:03:55 2006","Sun Jul 9 12:01:42 2006","Thu Mar 28 10:21:50 2002","Fri Dec 14 10:06:47 2001","Fri Dec 14 10:06:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0075 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:13:59 2001","Sun Jul 9 12:01:42 2006","pdb1HDJ Human Hsp40 (Hdj-1), Nmr 95 1e-020pdb1BQZ J-Domain (Residues 1-77) Of The Escherichia Coli N... 90 5e-019pdb1BQ0 J-Domain (Residues 1-77) Of The Escherichia Coli N... 90 5e-019","SMU.83","","Residues 5 to 69 (E-value = 7e-37) place SMu0075 in the DnaJ family which is described as DnaJ domain (PF00226)Residues 133 to 217 (E-value = 8.9e-37) place SMu0075 in the DnaJ_CXXCXGXG family which is described as DnaJ central domain (4 repeats) (PF00684)Residues 230 to 351 (E-value = 3.9e-73) place SMu0075 in the DnaJ_C family which is described as DnaJ C terminal region (PF01556)","Sun Jul 9 12:01:42 2006","24378607","","","Tang W, Wang Cc CC.Zinc Fingers and Thiol-Disulfide Oxidoreductase Activities of Chaperone DnaJ.Biochemistry. 2001 Dec 11;40(49):14985-94.PMID: 11732919Ben-Zvi AP, Goloubinoff P.Review: mechanisms of disaggregation and refolding of stable protein aggregates by molecular chaperones.J Struct Biol. 2001 Aug;135(2):84-93.PMID: 11580258","","Fri Dec 14 10:13:59 2001","1","","","SMU.83","14" "SMu0076","89443","90192","750","ATGATACGGTATAAAGCGATTATTTCCTATGATGGCACTAATTTTTCGGGTTTCCAAAGGCAGCCGCAGGTGAGAACAGTGCAAGAGGAAATTGAAAAGACTCTTTTACGTTTGAATAGCGGGCAGGCTGTTAAGATACATGGGGCTGGCCGAACAGATGCGGGTGTGCATGCTTATGGTCAAGTCATTCATTTTGATTTGCCGCAGCAAAGGGATTTAGAAAAACTGCGTTTTGGCCTTGATACACAGACACCAGATGATATTGATGTTATTCAGGTTGAACAAGTAGCAGATGATTTTCATGCTCGTTACCAAAAGCATCGCAAAACCTATGAATTTTTAGTAGATTTGGGGAGACCTAAGAATCCTTTGATGCGCCATTATGCCACCCATTTTCCGTATAAAGTGGATTTTTCAGTTGTTAAAGCGGCTATTAAAAAATTACGTGGAACCCATGATTTCACTGGTTTTACAGCGTCTGGTACTAGCGTGGAAAACAAGGTTAGAACAATCAGCCGTGCTACTGTTGAAAAAGACGACAAGACTGGATTTCTCATTTTTACGTTTACAGGAAGTGGTTTTCTTTACAAACAAGTCAGAAATATGGTTGGAACCCTATTAAAAATTGGCAATGGCCGCATGCCGATTGACCAAATTGACAGAATTTTAGAATCTGGGGACCGCAGTCTAGCTGGTCCGACAGCTGCAAGCAATGGACTTTATCTTAAGGAGATTATTTATGACGACTAA","10.10","6.93","28172","MIRYKAIISYDGTNFSGFQRQPQVRTVQEEIEKTLLRLNSGQAVKIHGAGRTDAGVHAYGQVIHFDLPQQRDLEKLRFGLDTQTPDDIDVIQVEQVADDFHARYQKHRKTYEFLVDLGRPKNPLMRHYATHFPYKVDFSVVKAAIKKLRGTHDFTGFTASGTSVENKVRTISRATVEKDDKTGFLIFTFTGSGFLYKQVRNMVGTLLKIGNGRMPIDQIDRILESGDRSLAGPTAASNGLYLKEIIYDD","90189","For other 'tru' genes see SMu1046 (truB).","tRNA pseudouridine synthase A","Cytoplasm","Several matches in gapped BLAST to TruA proteins. Residues 1-249 are 72% similar to the enzyme in S.pneumoniae (gi|15903494) and the enzyme from S.pyogenes (gi|15675714). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0100 (1e-109).","

InterPro
IPR001406
Family

tRNA pseudouridine synthase
G3DSA:3.30.70.580	$\"[1-106]T$	PseudoU_synth_1
G3DSA:3.30.70.660	$\"[107-245]T$	PseudoU_synth_1
PTHR11142	$\"[4-249]T$	PseudoU_synth_1
PF01416	$\"[6-105]T$ $\"[144-248]T$	PseudoU_synth_1
TIGR00071	$\"[4-242]T$	hisT_truA

noIPR
unintegrated

unintegrated
SSF55120	$\"[1-249]T$	SSF55120

","BeTs to 17 clades of COG0101COG name: Pseudouridylate synthase (tRNA psi55)Functional Class: JThe phylogenetic pattern of COG0101 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001406 (tRNA pseudouridine synthase) with a combined E-value of 8.9e-58. IPB001406A 3-31 IPB001406B 49-65 IPB001406C 84-115 IPB001406D 148-159 IPB001406E 191-206 IPB001406F 233-242","Residues 49-214 are 25% similar to a (CG7042 Y73B6BL.X) protein domain (PD282698) which is seen in Q9W0U3_DROME.Residues 1-247 are 60% similar to a (SYNTHASE TRNA PSEUDOURIDINE) protein domain (PD003202) which is seen in TRUA_LACLA.Residues 49-248 are 30% similar to a (I PROTEOME COMPLETE SYNTHASE) protein domain (PD227834) which is seen in Q9HNP6_HALN1.Residues 43-247 are 30% similar to a (SYNTHASE PSEUDOURIDINE TRNA) protein domain (PD180648) which is seen in Q9PDK6_XYLFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:04:49 2002","Fri Dec 14 10:15:13 2001","Fri Dec 14 10:18:39 2001","Thu Apr 4 13:22:16 2002","Fri Dec 14 10:15:13 2001","Fri Dec 14 10:15:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0076 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:15:13 2001","Fri Dec 14 10:15:13 2001","pdb|1DJ0|A Chain A, The Crystal Structure Of E. Coli Pseudourid... 147 1e-036","SMU.84","","Residues 6 to 105 (E-value = 2.1e-40) place SMu0076 in the PseudoU_synth_1 family which is described as tRNA pseudouridine synthase (PF01416)Residues 144 to 248 (E-value = 2.1e-32) place SMu0076 in the PseudoU_synth_1 family which is described as tRNA pseudouridine synthase (PF01416)","Fri Dec 14 10:15:13 2001","24378608","","","Urbonavicius J, Qian Q, Durand JM, Hagervall TG, Bjork GR.Improvement of reading frame maintenance is a common function for several tRNA modifications.EMBO J. 2001 Sep 3;20(17):4863-73.PMID: 11532950","","Fri Dec 14 10:21:52 2001","1","","","SMU.84","230" "SMu0077","90182","90949","768","ATGACGACTAAGTATATTTTAGCTATTTCAGGTAACGATATTTTTAGTGGAGGTGGGCTTCATGCAGATCTAGCAACTTTCACAAGCCATCATTTACATGGTTTTGTAGCAGTGACTTGCTTAACAGCAATGACTGATAAAGGCTTTGAAGTGTTTGCAACAGACAAAGCTGTTTTTGGCCATCAACTCAGTAGTCTCAAAGATGTGCCGCTTTCAGGTATTAAGCTTGGTCTTTTGCCTAATGTGGACATAGCAGAGCAGGCTTTGGATTTTGTTAAGGTACATGACGATCTTCCAGTAGTACTTGATCCTGTCTTGGTTTGTAAAGAAAGTCATGATGTAGAGGTTAGTGCTTTGAGGGATGAGCTCTTAAAATTTTTCCCCCATACTGCTGTTATTACTCCGAATTTGGCTGAAGCTGAATTATTGACGCAAATGCCGATAAAAAATCTTGATGATATGAAGGCAGCTGCCAAATGCCTTTATCATTTAGGTGCTAAAAATGTTGTTGTTAAAGGAGGAACGAGACTGAGTTCAAAACGAGCGATAGATGTCTTTTTTGATGGTGAAAAGATGGAAGTTTTGGATTATCCTTTGCTGGCAAATAACAATATCGGTGCAGGCTGTACTTTTGCATCAAGCATTGCCAGTCAAATAGTGTTAGGTAAGTCCGTTTTAGAAGCAGTTAAAGTATCCAAAGAATTTGTCTATCAGGCTATTCAGCATTCAGATCAATACGGAGTCAATCAACATTATGAAAAACAGTAA","6.10","-5.54","27669","MTTKYILAISGNDIFSGGGLHADLATFTSHHLHGFVAVTCLTAMTDKGFEVFATDKAVFGHQLSSLKDVPLSGIKLGLLPNVDIAEQALDFVKVHDDLPVVLDPVLVCKESHDVEVSALRDELLKFFPHTAVITPNLAEAELLTQMPIKNLDDMKAAAKCLYHLGAKNVVVKGGTRLSSKRAIDVFFDGEKMEVLDYPLLANNNIGAGCTFASSIASQIVLGKSVLEAVKVSKEFVYQAIQHSDQYGVNQHYEKQ","90946","For other 'thi' genes see SMu0766 (thiI). ","phosphomethylpyrimidine kinase","Cytoplasm","Several matches in gapped BLAST to phosphomethylpyrimidine kinase sequences. Residues 1-251 are 58% similar to the enzyme from S.pneumoniae (gi|15903493). Residues 1-254 are 55% similar to the enzyme from S.pyogenes (gi|15675713).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0101 (2e-83).","

InterPro
IPR013749
Domain

Phosphomethylpyrimidine kinase type-1
PF08543	$\"[13-249]T$	Phos_pyr_kin

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.20	$\"[3-255]T$	G3DSA:3.40.1190.20
PTHR20858	$\"[1-247]T$	PTHR20858
SSF53613	$\"[3-247]T$	SSF53613

","BeTs to 11 clades of COG0351COG name: Hydroxymethylpyrimidine/phosphomethylpyrimidine kinaseFunctional Class: HThe phylogenetic pattern of COG0351 is amtkYqv-eBrhuj---l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 6-72 are 46% similar to a (KINASE PHOSPHOMETHYLPYRIMIDINE PROTEOME) protein domain (PD100509) which is seen in Q9CI79_LACLA.Residues 109-242 are 50% similar to a (KINASE TRANSFERASE PHOSPHOMETHYLPYRIMIDINE PROTEOME) protein domain (PD003501) which is seen in Q9CI79_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 16:51:50 2002","Fri Dec 14 10:22:50 2001","Tue Oct 22 16:45:20 2002","Thu Apr 4 13:24:16 2002","","Fri Dec 14 10:22:50 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0077 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:25:11 2001","","No significant hits to the NCBI PDB database.","SMU.85","","No significant hits to the Pfam 11.0 database","Fri Dec 14 10:22:50 2001","24378609","","","Mizote T, Tsuda M, Smith DD, Nakayama H, Nakazawa T.Cloning and characterization of the thiD/J gene of Escherichia coli encoding a thiamin-synthesizing bifunctional enzyme, hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase.Microbiology. 1999 Feb;145 ( Pt 2):495-501.PMID: 10075431Imamura N, Nakayama H.thiD locus of Escherichia coli.Experientia. 1981 Dec 15;37(12):1265-6.PMID: 6276219","","Fri Dec 14 10:31:40 2001","1","","","SMU.85","513" "SMu0078","90936","91400","465","ATGAAAAACAGTAATTTACAAGAAATCAGTCTTTTAGCTGTCTTAACAGCTTTAAGCGTTGTTTTTGGGTTATTTATTAAAATTCCGACACCAACTGGCTTTTTAACTTTATTAGATGCAGGTATTTATTTTACAGCCTTTTATCTAGGCTCCCAAGAAGCTGCGATTGTTGGTGGTTTATCTGGTTTTTTAATTGATTTGATTGCCGGTTACCCTAATTGGATGTTTATCAGTTTTTTAGCGCATGGCTCACAAGGTTACTTTGCTGGTTGGACTGGGAAAAAACAATTTTTAGGTCTGGCTTTAGCTTCCCTGTCTATGATTAGTATTTATTTGCTCTGTTCCATTCCTATGTATGGATTAGGAGCTTCAATTGCCGGTGCTTGGGGCAATATTTTGCAAAACTTTTTTGGTATGTTTGTTGGTTATACGCTTAGCCTTGCCTATAGGCGCGTGAAGCCTTGA","9.80","3.17","16586","MKNSNLQEISLLAVLTALSVVFGLFIKIPTPTGFLTLLDAGIYFTAFYLGSQEAAIVGGLSGFLIDLIAGYPNWMFISFLAHGSQGYFAGWTGKKQFLGLALASLSMISIYLLCSIPMYGLGASIAGAWGNILQNFFGMFVGYTLSLAYRRVKP","91397","","conserved hypothetical protein","Membrane, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 1-153 are 52% similar to a protein from S.pyogenes (gi|15675712) and 49% similar to a protein from S.pneumoniae (gi|15901437). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0102 (1e-41).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-23]?$	signal-peptide
tmhmm	$\"[4-26]?$ $\"[28-48]?$ $\"[54-76]?$ $\"[97-119]?$ $\"[125-147]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 28-146 are 46% similar to a (PROTEOME COMPLETE PH1832 YEIE) protein domain (PD407678) which is seen in Q9CI78_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:06:29 2002","Fri Dec 14 10:34:58 2001","Fri Dec 14 10:35:51 2001","Fri Dec 14 10:34:58 2001","","Fri Dec 14 10:34:58 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0078 is paralogously related (blast p-value < 1e-3) to SMu1758, a conserved hypothetical.","Fri Dec 14 10:35:51 2001","","No significant hits to the NCBI PDB database.","SMU.86","","No significant hits to the Pfam 11.0 database","Fri Dec 14 10:34:58 2001","24378610","","","","","","1","","","SMU.86","881" "SMu0079","91445","92008","564","ATGGATTTAGAAAACTTAGCCGAAGAAACGAGAATTGTTCTAGCAGATCTTATTAAACGAAGCGACATCAAGAAAGGACAGATTTTTGTTTTAGGTCTGTCCAGCAGTGAGGTTGCCGGTGGTGTAATTGGGAAGAATTCTAATCTTGACATCGGAGAAGTTATTGTTAAGACGATTCTTACTTATCTCAATGACAGAGGAATTTACCTAGCGGTTCAGGGGTGTGAACATCTCAATCGTGCTCTTGTGGTTGAACGAGAGTTAGCTGATAAAAGAAATTTGGAAATTGTAAATGTCCTGCCTAATCTTCATGCTGGCGGCAGTGGTCAACTAGCAGCTTTTAAATACATGAAAGATCCTGTGGAAGTTGAAGAAATTGTAGCTGATGCAGGTCTTGATATTGGGGATACTGCTATTGGTATGCACGTGAAACGCGTCCAAGTTCCTTTGCGTCCTCTCCTAAGAGAACTGGAGGGTGCTCATTTGACGGCTCTTGCCAGTCGGCCTAAGTTAATCGGCGGCAGCCGTGCTAGCTATCAGCCAGATCCTATTCGTAAATTTTAA","6.50","-1.08","20341","MDLENLAEETRIVLADLIKRSDIKKGQIFVLGLSSSEVAGGVIGKNSNLDIGEVIVKTILTYLNDRGIYLAVQGCEHLNRALVVERELADKRNLEIVNVLPNLHAGGSGQLAAFKYMKDPVEVEEIVADAGLDIGDTAIGMHVKRVQVPLRPLLRELEGAHLTALASRPKLIGGSRASYQPDPIRKF","92005","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 3-186 are 65% similar to gi|15675711 from S.pyogenes. Residues 1-187 are 67% similar to gi|15900564 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0103 (1e-75).","

InterPro
IPR006340
Family

Conserved hypothetical protein 1440
G3DSA:3.40.50.10360	$\"[3-185]T$	CHP1440
PIRSF007510	$\"[3-187]T$	UCP007510
PF04260	$\"[8-179]T$	DUF436
TIGR01440	$\"[8-179]T$	CHP1440

noIPR
unintegrated

unintegrated
SSF110710	$\"[3-187]T$	SSF110710

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-180 are 66% similar to a (PROTEOME COMPLETE SPOIIR-GLYC BH3766) protein domain (PD102102) which is seen in Q9CI77_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:06:47 2002","Fri Dec 14 10:45:37 2001","Tue Oct 8 17:06:47 2002","Fri Dec 14 10:45:37 2001","","Fri Dec 14 10:45:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0079 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:45:37 2001","","No significant hits to the NCBI PDB database.","SMU.87","","Residues 8 to 179 (E-value = 1.2e-116) place SMu0079 in the DUF436 family which is described as Protein of unknown function (DUF436) (PF04260)","Fri Dec 14 10:45:37 2001","24378611","","","","","","1","","","SMU.87","620" "SMu0080","93036","92179","858","ATGAAATTGATTACTTCTTATTTTGGCCGTTTTAACTTAGAAAACCTCTTATTTGAATTTGCGTCAAAACTATTGTCCCTTCTGCTTCTACTCATTGTTTTTATTATTGCTAAAAGAGTTATTAGTTATCTTTTTGAAAAAACAATTGCAAGATCCACTGCTCTAGCTAGATATAGCCAAGGCCGACAAAAAACCTTGATTAAGCTTTTTCATAATATCATGGATTATAGTCTCTATTTTCTGTTGATATATTGGATTTTAGCTATTATTGGTCTGCCTGTTTCAAGCCTTCTAGCTGGTGCAGGTATTGCAGGGGTGGCTATTGGTCTTGGTGCTCAAGGATTCCTTTCCGATCTGGTAAATGGCTTTTTCATTTTGTTGGAACGTCAGTTTGATGTTGGAGATTCCGTTAAATTAAGAGCAACAACGGGTTCAATCTCTGGAACAGTCTCTAGTGTTGGCATCCGAACCACACAAATTCGTGATTTTGATGGCACTCTGCATTTCGTCCCCAATCGCAATATTACCATCGTCAGTAATTTGTCACGCGGTGATATGCGAGCACAGATAGATATTCCTATCTATGCTAATACTAATCTTAGACAAGTAACTACCATTATCAAGCAAGTCAATGAAGACAATATCAGTCAGTTTCCTGAAATCGTTGGTGTTCCTAATATCTTAGGAGCAACGACCTCTCCCGTCACAGGTCAAATCGTTTTTCGAATAGATATTTTTGTTCAAAATAGCAAGCAAAATCATATTTACTATACTTTTTATCGCCTCTATCAAGAAGCATTGCTGGCAAATCATATTTCCCTGCCAACAGCTAATGCCATCCCTATTGCTAAAAAATAA","10.60","9.95","31726","MKLITSYFGRFNLENLLFEFASKLLSLLLLLIVFIIAKRVISYLFEKTIARSTALARYSQGRQKTLIKLFHNIMDYSLYFLLIYWILAIIGLPVSSLLAGAGIAGVAIGLGAQGFLSDLVNGFFILLERQFDVGDSVKLRATTGSISGTVSSVGIRTTQIRDFDGTLHFVPNRNITIVSNLSRGDMRAQIDIPIYANTNLRQVTTIIKQVNEDNISQFPEIVGVPNILGATTSPVTGQIVFRIDIFVQNSKQNHIYYTFYRLYQEALLANHISLPTANAIPIAKK","92182","","mechanosensitive ion channel protein","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 1-285 are 49% similar to gi15675710 of S.pyogenes. Residues 2-185 are 39% similar to gi15903639 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0104 (5e-71).","

InterPro
IPR006685
Family

MscS Mechanosensitive ion channel
PF00924	$\"[71-275]T$	MS_channel

InterPro
IPR010920
Domain

Like-Sm ribonucleoprotein-related, core
SSF50182	$\"[114-182]T$	Sm_like_riboprot

InterPro
IPR011014
Domain

MscS Mechanosensitive ion channel, transmembrane
SSF82861	$\"[20-113]T$	MscS_transmembr

InterPro
IPR011066
Domain

MscS mechanosensitive ion channel, C-terminal
SSF82689	$\"[182-275]T$	MscC_channel_C

","BeTs to 11 clades of COG0668COG name: Uncharacterized ACR, integral membrane protein, YjeP/UPF0003 familyFunctional Class: SThe phylogenetic pattern of COG0668 is aMtk-QvCEBRhUJ--ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB001880 (Uncharacterized protein family UPF0003) with a combined E-value of 1.1e-28. IPB001880A 102-137 IPB001880B 150-183","Residues 32-128 are 32% similar to a (COMPLETE PROTEOME TRANSMEMBRANE INTEGRAL) protein domain (PD002190) which is seen in Q9K9I1_BACHD.Residues 130-208 are 44% similar to a (PROTEOME COMPLETE TRANSMEMBRANE INTEGRAL) protein domain (PD002444) which is seen in O34897_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 22 10:16:59 2006","Tue Aug 22 10:16:59 2006","Tue Aug 22 10:16:59 2006","Tue Aug 22 10:16:59 2006","Fri Dec 14 10:48:42 2001","Fri Dec 14 10:48:42 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0080 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:48:42 2001","","No significant hits to the NCBI PDB database.","SMU.88c","","Residues 72 to 275 (E-value = 1.4e-44) place SMu0080 in the MS_channel family which is described as Mechanosensitive ion channel (PF00924)","Fri Dec 14 10:48:42 2001","24378612","","","","","","1","","","SMU.88c","514" "SMu0081","94063","93254","810","ATGACTGATACAACTATTACAAGCACTTTTTATGAAAAAATTGCTTCCGCCTGTCGCAAAAAAGAGGCACTTTTTGATGAAAACCTTGGCCGTTACGCTCTGCGTTCCATGTTTGCTGGTGCTTATTTGACAATGAGTACTGCAGTCGGTGTAGTTGCAGCCGATGTTATTTCACAATTCTCACTTGCCTTTGGACGATTTGCTTTTGCTTTTATTTTTAGTTTCGGCTTGGTTTATGTTTTGCTCTTCAATGGTGAGTTAGCGACATCAAACATGATGTTTCTCTCTTCAGGAGCTTACTACAAACACATCTCTTTCAAGAAAGCCATAACCATTTTATTGACATGTACTTTTTTCAATTTAATCGGTGCTATCATTTTAGCTTGGCTCTTTAACCAATCTTTCTCTTTTGCTCAATTGACACATAAAAGCTTTTTAGTTAATGCCGTTCAAACCAAATTAGCTAAGAGCGATTGGCAAAACTTCTTTGAAGGCATTACAGCCAATATGTTTGTCAATATTGCGATTTTAGGGTACATGCTTCTTAAAGAAGAAAGTGCCAAAATTACTATTGCTCTTTCGGCTATCTTTATGTTTGTCTTTTTAATCAACGAACACTTGATCGCCAACTTTGCCTCATTTATGCTGGCAGCTTTTAGTTCTGTAGAACACATTAAAGGACTTGAATTTTTCAATGTTATCCGTCAATGGATTATTGTTTTCTTCGGTAACTGGATTGGTGGCGGCATCTTTATCGGTCTGGCTTATGCTTGGCTTAATCAGACTAAAACGCCGCATAAAGAACAATAA","9.60","5.10","30209","MTDTTITSTFYEKIASACRKKEALFDENLGRYALRSMFAGAYLTMSTAVGVVAADVISQFSLAFGRFAFAFIFSFGLVYVLLFNGELATSNMMFLSSGAYYKHISFKKAITILLTCTFFNLIGAIILAWLFNQSFSFAQLTHKSFLVNAVQTKLAKSDWQNFFEGITANMFVNIAILGYMLLKEESAKITIALSAIFMFVFLINEHLIANFASFMLAAFSSVEHIKGLEFFNVIRQWIIVFFGNWIGGGIFIGLAYAWLNQTKTPHKEQ","93257","","nitrite transporter","Membrane, Cytoplasm","Several hits in gapped BLAST to nitrite transporters. Residues 6-263 are 44% similar to an FNT family transporter from S.pneumoniae (gi15901077). Residues 7-268 are 35% similar to a transporter from Listeria monocytogenes (gi16802636).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1084 (4e-90).","

InterPro
IPR000292
Family

Formate/nitrite transporter
PF01226	$\"[5-263]T$	Form_Nir_trans

","BeTs to 3 clades of COG2116COG name: Formate/nitrite family of transportersFunctional Class: PThe phylogenetic pattern of COG2116 is ----y---EB-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB000292 (Formate and nitrite transporters) with a combined E-value of 1.6e-24. IPB000292A 67-93 IPB000292B 113-131 IPB000292C 172-219 IPB000292D 236-257 IPB000292B 237-255","Residues 12-235 are 24% similar to a (TRANSPORTER FORMATE TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD006963) which is seen in YWCJ_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 10 16:54:55 2006","Fri Dec 14 10:53:15 2001","Mon Jul 10 16:54:55 2006","Mon Jul 10 16:54:55 2006","Fri Dec 14 10:53:15 2001","Fri Dec 14 10:53:15 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0081 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:53:15 2001","","No significant hits to the NCBI PDB database.","SMU.89c","","Residues 5 to 263 (E-value = 2.3e-10) place SMu0081 in the Form_Nir_trans family which is described as Formate/nitrite transporter (PF01226)","Fri Dec 14 10:53:15 2001","24378613","","","","","","1","","","SMU.89c","807" "SMu0082","94301","95584","1284","ATGTCTACATCATTTGAAAACAAAGCTACCAATCGTGGTGTTGTTACATTTACGATCAGTCAAGATAAAATCAAACCAGCTCTTGATCAGGCCTTTAATAAAGTTAAAAAGGATTTAACAGCACCAGGTTTCCGTAAAGGTCATATGCCACGTACTGTTTTTAATCAAAAATTTGGAGAAGAGGCTCTTTATGAAGAGGCTTTAAACAGTATTTTACCAGCAGCTTATGAAGAAGCCGTTGCTGAATTAGAACTTGATGTTGTCACTCAGCCGAAAGTTGATGTTAAGTCAATGGAAAAAGGTAAGGATTGGGAAATTACAGCAGAAGTTGTAACAAAACCAGAAGTAAAGCTTGGAGATTACAAAAATCTTGAAGTATCAGTAGAAGAATCAAAAGAGGTTACTGATGCAGAAGTTGATGAAAAAATTGAACGTGAACGCAATAATTTAGCTGAACTGGTTCTTAAAGAAGATGCAGCAGTTGAAGGTGATACTGTCGTGATTGACTTTGTTGGTTCAGTTGATGGTGTTGAATTTGATGGTGGTAAAGGCGATAATTTCTCGCTTGAACTTGGTTCTGGTCAGTTTATACCAGGTTTTGAAGATCAATTGGTTGGCAAAAAGGCTGGTGAGACAGTTAAGGTTAATGTTACTTTCCCAGAAGATTACCAATCTGCTGATCTTGCAGGCAAAGATGCAACATTCGTAACGACTATTCATGAAGTTAAGGCCAAGGAAGTTCCAGAACTTGATGATGAATTGGCTAAAGATATTGATGAAGAAGTTGAAACATTGGATGAACTAAAAGCTAAGTATCGTAAGGAACTGGAAGCTACTAAAGAGACTGCATACAATGATGCTGTTGAAGCAGCAGCTATTGACTTAGCGGTCGCTAATGCTGAAATCGTTGAATTGCCGGAAGAAATGATTCATGATGAGGTCCAACGTGCGATGCAAGAATTCATGGGTAATATGCAGCGCCAAGGGATTTCATCAGAGATGTACTTCCAATTGACAGGTACAACTGAAGAGGATCTTCGCAAGCAATACGAAGCGGATGCTGACAAACGCGTAAAAACAAACCTTGTTATTGAAGCAGTTGCTAAAGCAGAAGGCTTTGAAGCGACAGATGAAGAAATTGAAAAAGAAATTTCTGATCTTGCAACAGAATACAAGATGGAAGCTGAGCAAGTGCGCTCTCTTCTTTCACCAGATATGCTCAAACATGACATTGCAATGAAAAAAGCGGTTAACGTTATTACTGATTCTGCTAAAGTTAAATAA","4.30","-42.94","47475","MSTSFENKATNRGVVTFTISQDKIKPALDQAFNKVKKDLTAPGFRKGHMPRTVFNQKFGEEALYEEALNSILPAAYEEAVAELELDVVTQPKVDVKSMEKGKDWEITAEVVTKPEVKLGDYKNLEVSVEESKEVTDAEVDEKIERERNNLAELVLKEDAAVEGDTVVIDFVGSVDGVEFDGGKGDNFSLELGSGQFIPGFEDQLVGKKAGETVKVNVTFPEDYQSADLAGKDATFVTTIHEVKAKEVPELDDELAKDIDEEVETLDELKAKYRKELEATKETAYNDAVEAAAIDLAVANAEIVELPEEMIHDEVQRAMQEFMGNMQRQGISSEMYFQLTGTTEEDLRKQYEADADKRVKTNLVIEAVAKAEGFEATDEEIEKEISDLATEYKMEAEQVRSLLSPDMLKHDIAMKKAVNVITDSAKVK","95581","","peptidyl-prolyl isomerase, trigger factor","Cytoplasm","Several matches in gapped BLAST to peptidyl-prolyl isomerase RopA (trigger factor) seqeunces. Residues 1-427 are 74% similar to the RopA factor from S.pyogenes and 69% similar to the protein from S.pneumoniae (gi15902406). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0105 (0.0).","

InterPro
IPR001179
Domain

Peptidyl-prolyl cis-trans isomerase, FKBP-type
PF00254	$\"[155-240]T$	FKBP_C
PS50059	$\"[163-245]T$	FKBP_PPIASE

InterPro
IPR005215
Family

Trigger factor
PIRSF003095	$\"[1-427]T$	Trigger_factor
TIGR00115	$\"[1-427]T$	tig

InterPro
IPR008880
Domain

Bacterial trigger factor, C-terminal
PF05698	$\"[241-417]T$	Trigger_C

InterPro
IPR008881
Domain

Bacterial trigger factor, N-terminal
PF05697	$\"[1-147]T$	Trigger_N

noIPR
unintegrated

unintegrated
G3DSA:1.10.3120.10	$\"[239-402]T$	G3DSA:1.10.3120.10
G3DSA:3.30.70.1050	$\"[1-112]T$	G3DSA:3.30.70.1050
SSF102735	$\"[1-128]T$	SSF102735
SSF109998	$\"[250-427]T$	SSF109998
SSF54534	$\"[88-245]T$	SSF54534

","BeTs to 12 clades of COG0544COG name: FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)Functional Class: OThe phylogenetic pattern of COG0544 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001179 (FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)) with a combined E-value of 1.1e-09. IPB001179 191-224","Residues 384-427 are 68% similar to a (FACTOR TRIGGER ROTAMASE DIVISION) protein domain (PD376680) which is seen in TIG_LACLA.Residues 2-117 are 71% similar to a (TRIGGER FACTOR CELL DIVISION) protein domain (PD005917) which is seen in TIG_STRPY.Residues 304-427 are 23% similar to a (FACTOR TRIGGER ROTAMASE DIVISION) protein domain (PD398865) which is seen in TIG_SYNY3.Residues 133-268 are 50% similar to a (TRIGGER FACTOR CELL DIVISION) protein domain (PD186215) which is seen in TIG_CAUCR.Residues 303-427 are 24% similar to a (DIVISION CELL TRIGGER FACTOR) protein domain (PD407616) which is seen in Q9F314_STRCO.Residues 118-397 are 74% similar to a (TRIGGER FACTOR CHAPERONE ROTAMASE) protein domain (PD328191) which is seen in TIG_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 3 14:36:16 2005","Sun Jul 9 12:10:44 2006","Thu Feb 3 14:36:16 2005","Thu Feb 3 14:36:16 2005","Fri Dec 14 10:54:29 2001","Fri Dec 14 10:54:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0082 is paralogously related (blast p-value < 1e-3) to SMu0676, a predicted FtsY protein.","Fri Dec 14 11:38:24 2001","","No significant hits to the NCBI PDB database.","SMU.91","","Residues 1 to 153 (E-value = 3.3e-64) place SMu0082 in the Trigger_N family which is described as Bacterial trigger factor protein (TF) (PF05697)Residues 155 to 240 (E-value = 4.2e-28) place SMu0082 in the FKBP_C family which is described as FKBP-type peptidyl-prolyl cis-trans isomerase (PF00254)Residues 241 to 417 (E-value = 5.4e-67) place SMu0082 in the Trigger_C family which is described as Bacterial trigger factor protein (TF) C-terminus (PF05698)","Thu Feb 3 14:36:16 2005","24378614","","Wen ZT, Suntharaligham P, Cvitkovitch DG, Burne RA.Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation.Infect Immun. 2005 Jan;73(1):219-25.PMID: 15618157","Wen ZT, Suntharaligham P, Cvitkovitch DG, Burne RA.Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development, and biofilm formation.Infect Immun. 2005 Jan;73(1):219-25.PMID: 15618157Lyon WR, Caparon MG.Trigger factor-mediated prolyl isomerization influences maturation of the Streptococcus pyogenes cysteine protease.J Bacteriol. 2003 Jun;185(12):3661-7.PMID: 12775704","Sun Jul 9 12:19:25 2006","Sun Jul 9 12:19:25 2006","1","","","SMU.91","15" "SMu0083","95861","95724","138","ATGGCAAAAGCTAAACAGCATAATCAGGGGAGGATCAAAGCCGAAAGACTAACCATTGAAACACAATTCTCAGTTCTATGTTCTGAGTTTGATATGGAAAGACCATTAGTGAGAAGTTTAGAAGGTTTGGGGCTTTGA","8.40","1.18","5114","MAKAKQHNQGRIKAERLTIETQFSVLCSEFDMERPLVRSLEGLGL","95727","","transposase fragment","Cytoplasm","This sequence is related to a previously published plasmid sequence in GenBank, gi|13897502; residues 1-45 are 73% similar to residues 238-282 of gi|13897502. See also other strep sequences gi|15383627 and gi|6716559.SMu0083 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:11:13 2002","Fri Dec 14 11:29:31 2001","Fri Dec 14 11:36:17 2001","Fri Dec 14 11:29:31 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0083 is paralogously related (blast p-value < 1e-3) to SMu0205, and SMu1213, transposase-related sequences.","Fri Dec 14 11:37:27 2001","","No significant hits to the NCBI PDB database.","SMU.92c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 11:29:31 2001","24378615","","","","","","1","","","SMU.92c","" "SMu0084","96090","95980","111","TTGGCTGTTGCCTATAATCCTTCAAAAGAGATGTGGTTTTACGGCTTTAAAGCCCATACGCTGGTGACCTGTCAGGATTTATTTGAACTATGTCGTGACACCAGCATCTGA","5.60","-0.88","4181","MAVAYNPSKEMWFYGFKAHTLVTCQDLFELCRDTSI","95983","","transposase fragment","Cytoplasm, Extracellular","This sequence is related to a previously published plasmid transposase fragment, gi|13897502. Residues 3-23 are 80% similar to residues 155-175 of gi|13897502. See also strep sequences gi|15383627 and gi|6716559.SMu0084 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:11:43 2002","Fri Dec 14 11:41:42 2001","Fri Dec 14 11:43:23 2001","Fri Dec 14 11:41:42 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0084 is paralogously related (blast p-value < 1e-3) to SMu0205, SMu0095, and SMu1213, transposase fragments.","Fri Dec 14 11:41:42 2001","","No significant hits to the NCBI PDB database.","SMU.93c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 11:41:42 2001","24378616","","","","","","1","","","SMU.93c","" "SMu0085","96461","96291","171","ATGGTGCTAGTTATGAAACAATTAAAGGCAATGTTTTCTTGCTATTATCGACGCTATGCCTCTACAGAACTGGCGCAGCGTCGAAATATCAATCATTGTAAAATTAGCAACAGCTCCATTCTTGTCCTTTTAGCGCTTCAAGTTGAACTTGACAGCAAATTCCAATACTGA","10.40","5.12","6599","MVLVMKQLKAMFSCYYRRYASTELAQRRNINHCKISNSSILVLLALQVELDSKFQY","96294","","transposase fragment","Cytoplasm, Extracellular","This sequence is related to a previously published plasmid fragment, gi|13897502. Residues 5-55 are 56% similar to residues 29-79 of gi|13897502. See also strep sequences gi|6716559 and gi|15383627.SMu0085 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:12:00 2002","Fri Dec 14 11:44:13 2001","Fri Dec 14 11:47:03 2001","Fri Dec 14 11:44:13 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0085 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 11:44:13 2001","","No significant hits to the NCBI PDB database.","SMU.94c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 11:44:13 2001","24378617","","","","","","1","","","SMU.94c","" "SMu0086","97182","97670","489","ATGTATTTTAGTGATCTCGTTAATGCGATTCAAGTTTATTTAGAAAAGTCAGATGCAGACATTCGTGAAGCGTTACCGTTTTTCTATTCAGACTTAAACACAGATGGTAGCTTTATCCCGCTTGGTGAAAACAAATGGGGTCTGCGATCTTGGTATGGTATTGATGAAATTGATGAAGAGATTGTGACACTTGAAGAAGATGAAGACGGTGCACCAAAACATAAGAGGAAACGTGTTAATGCCTTTATGGATGGTGATGAGGATGCTATTGATTACAGTGATGACGATCCTGAAGATGAAAGTTTTAATACCGCTGAAGAGGATACAGAATATGATGAGGAAGATCCAGATGATGAAAAGTCCGAGGTTGAATCCTATGATTCTGAAATCAATGAAATCATTCCAGATGAAGATTTAGACGAAAATGTTGATTTAGATGAAGAAGATGACGATTATTCTGATGATGAGGAAGATGAAGAAGGAGAATAA","3.40","-54.71","18785","MYFSDLVNAIQVYLEKSDADIREALPFFYSDLNTDGSFIPLGENKWGLRSWYGIDEIDEEIVTLEEDEDGAPKHKRKRVNAFMDGDEDAIDYSDDDPEDESFNTAEEDTEYDEEDPDDEKSEVESYDSEINEIIPDEDLDENVDLDEEDDDYSDDEEDEEGE","97667","For other 'rpo' genes see, SMu0746 (rpoD); Smu1817 (rpoA); Smu1807 (rpoB); SMu1806 (rpoC) and SMu0433 (rpoZ).For DNA-directed RNA polymerase, omega subunit see SMu0433.For DNA-directed RNA polymerase, beta subunit see SMu1807.For DNA-directed RNA polymerase, beta' subunit see SMu1806.For DNA-directed RNA polymerase, alpha subunit see SMu1817.","DNA-directed RNA polymerase, delta subunit","Cytoplasm","Several matches in gapped BLAST to RpoE sequences. Residues 1-135 are 73% similar to RPOE_STRPY (gi15675708) and 62% similar to gi15900407 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0106 (2e-55).","

InterPro
IPR007759
Family

DNA-directed RNA polymerase delta subunit
PF05066	$\"[1-159]T$	RNA_pol_delta

noIPR
unintegrated

unintegrated
PTHR23405	$\"[1-160]T$	MAINTENANCE OF KILLER 16 (MAK16) PROTEIN-RELATED
PTHR23405:SF1	$\"[1-160]T$	DNA-DIRECTED RNA POLYMERASE, DELTA SUBUNIT

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 62-135 are 60% similar to a (RNA DNA-DIRECTED DELTA POLYMERASE) protein domain (PD390241) which is seen in RPOE_STRPY.Residues 1-100 are 57% similar to a (RNA DNA-DIRECTED DELTA POLYMERASE) protein domain (PD065609) which is seen in RPOE_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 24 15:18:08 2006","Fri Dec 14 11:48:41 2001","Mon Jul 24 15:18:08 2006","Fri Dec 14 11:48:41 2001","","Fri Dec 14 11:48:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0086 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 11:48:41 2001","","No significant hits to the NCBI PDB database.","SMU.96","","Residues 1 to 159 (E-value = 7.1e-57) place SMu0086 in the RNA_pol_delta family which is described as DNA-directed RNA polymerase delta subunit (PF05066)","Fri Dec 14 11:48:41 2001","161486824","","","Hild E, Takayama K, Olsson RM, Kjelleberg S.Evidence for a role of rpoE in stressed and unstressed cells of marine Vibrio angustum strain S14.J Bacteriol. 2000 Dec;182(24):6964-74.PMID: 11092857Lopez de Saro FJ, Yoshikawa N, Helmann JD.Expression, abundance, and RNA polymerase binding properties of the delta factor of Bacillus subtilis.J Biol Chem. 1999 May 28;274(22):15953-8.PMID: 10336502Lopez de Saro FJ, Woody AY, Helmann JD.Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase.J Mol Biol. 1995 Sep 15;252(2):189-202.PMID: 7545758 ","","Fri Dec 14 11:56:15 2001","1","","","SMU.96","621" "SMu0087","97804","99414","1611","ATGACAAAATATATTTTTGTAACAGGTGGTGTCGTTTCGTCAATTGGTAAGGGAATTGTTGCTGCAAGTCTTGGACGTCTTTTGAAAAATCGTGGGCTTAAAGTAACCATTCAAAAATTTGATCCGTATATTAATATTGATCCTGGAACAATGAGTCCTTATCAGCATGGTGAAGTTTATGTGACTGATGATGGTGCTGAAACTGACCTTGACCTTGGACATTACGAACGTTTCATTGATATTAATCTGAATAAATATTCAAATGTTACAACAGGAAAGATATATAGCGAGGTTCTGCGTAAAGAACGTAAAGGTGAATATCTTGGAGCAACTGTTCAAGTTATTCCCCATATTACAGATGCTCTAAAAGAAAAAATTAAACGTGCAGCTACAACAACAGACTCAGATGTTATTATCACTGAAGTTGGTGGTACGGTTGGTGATATTGAAAGCTTGCCCTTCCTTGAAGCCCTTCGTCAAATGAAAGCTGATGTGGGTGCTGATAATGTCATGTATATTCATACGACTTTGCTTCCTTATCTTAAAGCTGCAGGAGAAATGAAAACAAAACCAACCCAACACTCTGTTAAAGAGCTGCGTGGTTTGGGAATTCAACCTAATATGCTTGTTATTCGGACAGAACAGCCAGCCGGACAAGGTATTAAAAATAAATTAGCTCAATTCTGTGATGTTGCTCCAGAAGCTGTTATTGAATCACTTGATGTGGATCATCTTTATCAAATTCCGTTAAATCTTCAAGCACAAAATATGGATCAGATTGTTTGTGATCACTTAAAACTGGATGTGCCTGTTGCCGATATGACCGAATGGTCAGCAATGGTTGATAAGGTTATGAATCTCAAGAAAAAGACTAAGATTGCTCTAGTTGGGAAATATGTAGAATTGCCAGATGCTTATTTATCAGTCGTTGAAGCTCTTAAGCATTCGGGCTATGTTAATGATACAGCCATTGATCTCAATTGGATTAATGCTAATGAGGTCACTCCTGAAACGGTTACTGATTTGCTGGGAGATGCTGATGGTATTATTGTTCCGGGTGGATTTGGCCATCGTGGAACAGAAGGGAAAATAGAAGCTATTCGTTATGCGCGTGAAAACGATGTGCCTATGCTAGGAATCTGTCTTGGCATGCAATTGACTTGTGTTGAATATGCTCGTCATGTCCTTAACCTTGAAGGAGCTAATTCTGCGGAATTGGATCCAGATACCAAATATCCAGTTATTGATATTATGCGCGATCAGATTGATATTGAGGATATGGGAGGAACGCTTCGCCTTGGCCTTTATCCATGTAAATTGAAATCAGGCAGCAAAACAGCATCAGCTTATAGCAATCAAGAGGTCGTACAGCGCCGTCACCGTCATCGTTATGAATTTAATAATGCCTTTCGTCAGCAATTTGAGGAGGCTGGTTTCGTATTTTCAGGAGTATCACCAGATAATCGCTTGGTAGAAGTGGTGGAATTGTCAGATAAAAAATTTTTTGTTGCAGCTCAATATCATCCAGAATTACAGTCTCGTCCGAATCGTCCGGAAGAACTTTATACAGCTTTTATTACTGCAGCGGTTGAAAACAGTCAGGCACATTAA","5.50","-12.81","59481","MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAATTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGADNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEQPAGQGIKNKLAQFCDVAPEAVIESLDVDHLYQIPLNLQAQNMDQIVCDHLKLDVPVADMTEWSAMVDKVMNLKKKTKIALVGKYVELPDAYLSVVEALKHSGYVNDTAIDLNWINANEVTPETVTDLLGDADGIIVPGGFGHRGTEGKIEAIRYARENDVPMLGICLGMQLTCVEYARHVLNLEGANSAELDPDTKYPVIDIMRDQIDIEDMGGTLRLGLYPCKLKSGSKTASAYSNQEVVQRRHRHRYEFNNAFRQQFEEAGFVFSGVSPDNRLVEVVELSDKKFFVAAQYHPELQSRPNRPEELYTAFITAAVENSQAH","99411","For other 'pyr' genes see SMu0542 (pyrD); SMu0780 (pyrR); SMu0781 (pyrP);SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH). ","CTP synthetase","Cytoplasm","Several matches in gapped BLAST to CTP synthetases. Residues 1-553 are 88% similar to the enzyme from S. pyogenes (gi|15675707). Residues 2-553 are 88% to the sequence from S.pneumoniae (gi|15902482). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0107 (0.0).","

InterPro
IPR000991
Domain

Glutamine amidotransferase class-I
PF00117	$\"[301-528]T$	GATase

InterPro
IPR004468
Family

CTP synthase
PTHR11550	$\"[117-536]T$	PyrG_synth
PF06418	$\"[2-277]T$	CTP_synth_N
TIGR00337	$\"[1-528]T$	PyrG

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-286]T$	G3DSA:3.40.50.300
G3DSA:3.40.50.880	$\"[287-531]T$	G3DSA:3.40.50.880
SSF52317	$\"[288-533]T$	SSF52317
SSF52540	$\"[1-272]T$	SSF52540

","BeTs to 16 clades of COG0504COG name: CTP synthase (UTP-ammonia lyase)Functional Class: FThe phylogenetic pattern of COG0504 is amtkYqvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000991 (Glutamine amidotransferase class-I) with a combined E-value of 1.2e-07. IPB000991A 376-385 IPB000991B 502-512","Residues 21-334 are 80% similar to a (CTP LIGASE SYNTHASE SYNTHETASE) protein domain (PD002309) which is seen in Q9CI75_LACLA.Residues 328-528 are 26% similar to a (TRANSFERASE PROTEOME PA2268 COMPLETE) protein domain (PD415969) which is seen in Q9L211_STRCO.Residues 426-532 are 83% similar to a (CTP LIGASE SYNTHASE SYNTHETASE) protein domain (PD002477) which is seen in Q9CI75_LACLA.Residues 343-410 are 67% similar to a (CTP AMIDOTRANSFERASE LIGASE BIOSYNTHESIS) protein domain (PD137961) which is seen in Q9HP32_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Nov 17 17:59:02 2002","Fri Dec 14 12:01:09 2001","Sun Nov 17 17:59:02 2002","Mon Apr 1 16:41:47 2002","Fri Dec 14 12:01:09 2001","Fri Dec 14 12:01:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0087 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 12:01:09 2001","","No significant hits to the NCBI PDB database.","SMU.97","","Residues 2 to 279 (E-value = 4.2e-214) place SMu0087 in the CTP_synth_N family which is described as CTP synthase N-terminus (PF06418)Residues 301 to 528 (E-value = 1e-69) place SMu0087 in the GATase family which is described as Glutamine amidotransferase class-I (PF00117)","Fri Dec 14 12:01:09 2001","24378619","","","Meng Q, Switzer RL.Regulation of transcription of the Bacillus subtilis pyrG gene, encoding cytidine triphosphate synthetase.J Bacteriol. 2001 Oct;183(19):5513-22.PMID: 11544212 Wylie JL, Berry JD, McClarty G.Chlamydia trachomatis CTP synthetase: molecular characterization and developmental regulation of expression.Mol Microbiol. 1996 Nov;22(4):631-42.PMID: 8951811 ","","Fri Dec 14 12:05:40 2001","1","","","SMU.97","16" "SMu0088","100574","101455","882","ATGGCAATCGTTTCAGCAGAAAAATTTGTCCAAGCAGCTCGTGATAATGGTTATGCTGTCGGTGGATTTAACACTAACAACCTTGAATGGACTCAAGCTATCTTGCGTGCAGCAGAAGCTAAAAAAGCTCCTGTTCTCATTCAAACTTCTATGGGTGCTGCCAAATATATGGGTGGTTATAAACTTTGTAAAGTTCTTATCGAAACTCTTGTAGAATCAATGGGAATCACTGTACCAGTTGCTATCCACCTTGACCATGGTCATTATGAAGATGCTCTTGAATGTATCGAAGTTGGCTATACTTCAATTATGTTTGATGGTTCTCATCTTCCAGTTGAAGAAAACCTTGAAAAAGCTAAAGAAGTTGTTGCAAAAGCACATGCTAAAGGTATTTCAGTAGAAGCTGAAGTTGGTACTATCGGTGGTGAAGAAGATGGTATCATCGGCCGCGGTGAATTGGCACCAATTGATGACGCTAAAGCAATGGTCGAAACCGGTATTGATTTCTTGGCAGCTGGTATTGGTAATATTCACGGTCCGTACCCAGCAAATTGGGAAGGTCTTGACCTTGATCACTTGAAAAAATTGACAGAGGCTGTTCCAGGTTTCCCAATTGTACTTCACGGTGGTTCAGGTATTCCTGATGACCAAATCCGCGCAGCAATTAAACTTGGTGTTGCCAAAGTTAACGTTAATACTGAATGTCAAATCGCATTTGCTAATGCTACACGTAAATTTGCTGCTGAATACGAAGCAAATGAAGCAGAATACGACAAGAAAAAACTCTTTGACCCACGTAAATTCTTGAAACCAGGTTTTGAAGCTATTACAGAAGCGGTTGAAGAACGTATTGATGTCTTTGGTTCAGAAGGTAAAGCTTAA","4.80","-14.19","31412","MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKLCKVLIETLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLEKAKEVVAKAHAKGISVEAEVGTIGGEEDGIIGRGELAPIDDAKAMVETGIDFLAAGIGNIHGPYPANWEGLDLDHLKKLTEAVPGFPIVLHGGSGIPDDQIRAAIKLGVAKVNVNTECQIAFANATRKFAAEYEANEAEYDKKKLFDPRKFLKPGFEAITEAVEERIDVFGSEGKA","101452","","fructose-bisphosphate aldolase","Cytoplasm","This corresponds to the previously sequenced gi3777457 and gi4322370 in GenBank.Several matches in gapped BLAST to class-II aldolases. Residues 1-293 are 78% similar to gi10944298 from S.bovis and are 78% similar to gi15900513 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0127 (1e-131).","

InterPro
IPR000771
Family

Ketose-bisphosphate aldolase, class-II
PD002376	$\"[1-284]T$	K_bP_aldolase
PIRSF001359	$\"[1-293]T$	F_bP_aldolase_II
PF01116	$\"[2-293]T$	F_bP_aldolase
TIGR00167	$\"[1-293]T$	cbbA
PS00602	$\"[74-87]T$	ALDOLASE_CLASS_II_1
PS00806	$\"[133-144]T$	ALDOLASE_CLASS_II_2

InterPro
IPR011289
Family

Fructose-1,6-bisphosphate aldolase, class II
TIGR01859	$\"[3-293]T$	fruc_bis_ald_

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[7-293]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51569	$\"[1-293]T$	SSF51569

","BeTs to 11 clades of COG0191COG name: Fructose/tagatose biphosphate aldolasesFunctional Class: GThe phylogenetic pattern of COG0191 is ----yqvcEBrhujgpol---Number of proteins in this genome belonging to this COG is 1","***** IPB000771 (Fructose-bisphosphate aldolase, class-II) with a combined E-value of 2.3e-97. IPB000771A 13-51 IPB000771B 78-89 IPB000771C 111-147 IPB000771D 170-182 IPB000771E 207-238 IPB000771F 259-276","Residues 2-293 are 78% similar to a (ALDOLASE LYASE FRUCTOSE-BISPHOSPHATE ZINC) protein domain (PD002376) which is seen in ALF_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:16:11 2002","Tue Sep 5 10:58:17 2006","Mon Jul 25 17:28:53 2005","Mon Jul 25 17:28:53 2005","Fri Dec 14 12:06:56 2001","Fri Dec 14 12:06:56 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0088 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 12:06:56 2001","","No significant hits to the NCBI PDB database.","SMU.99","","Residues 2 to 293 (E-value = 4.5e-113) place SMu0088 in the F_bP_aldolase family which is described as Fructose-bisphosphate aldolase class-II (PF01116)","Fri Dec 14 12:06:56 2001","24378620","","Jado,I., Fenoll,A., Cepeda,T., Casal,J. and Perez,A.Cloning, sequencing, and chromosomal location of a putativeclass-II aldolase gene from Streptococcus pneumoniaeCurr. Microbiol. 39 (1), 31-36 (1999)PubMed: 99315350Qi,F., Chen,P. and Caufield,P.W.Functional analyses of the promoters in the lantibiotic mutacin IIbiosynthetic locus in streptococcus mutansAppl. Environ. Microbiol. 65 (2), 652-658 (1999)PubMed: 99124602","Gavilanes FG, Gavilanes JG.Role of tyrosine residues on structure-function of fructose-1,6-biphosphate aldolase from Ceratitis capitata.Int J Pept Protein Res. 1982 Feb;19(2):137-42.PMID: 7118391","Tue Oct 8 17:16:11 2002","Fri Dec 14 12:11:53 2001","1","","4","SMU.99","231" "SMu0089","101780","102271","492","ATGACAGTTGTTGAGGCTAGAGTAGATCAAAGATTAATCCATGGAATTGTAGTGAATCAGTGGAATTCGAAACTGAATCCTAAACGGTTTATGATTATTGATGATATTGTAAGCAATCAGCCAGAGATAAAAAATTCTATGAGGATGGCGAAGCCCTCTGGGAAAAGCATGAGTATTATTGATACACAAAAGGCTATTGCAAATTTCAAAAATGGTAATTATGATAAGCAAGATGTGTTTATCATTGTCAAAGAACCTTCTACTTTGCTTAAATTACTTGACAATGGTATTTCTATTCCCAGAGTAAACTTAGGAATTGTGTTTGCTGATGATGTTAGGACAAATGTCAGTAAGTTCGTAAATCTGAATCAATCTGAAGTAAATGAATTGAAGAAAATTGAGGAACGTGGAATTCCAATCATCATTCAATATATTCCGGATGATTCTGTAATTGTCTTTGAAAAGGCAATAGAAAATAAAAAATTTAAATGA","10.10","4.24","18552","MTVVEARVDQRLIHGIVVNQWNSKLNPKRFMIIDDIVSNQPEIKNSMRMAKPSGKSMSIIDTQKAIANFKNGNYDKQDVFIIVKEPSTLLKLLDNGISIPRVNLGIVFADDVRTNVSKFVNLNQSEVNELKKIEERGIPIIIQYIPDDSVIVFEKAIENKKFK","102268","","sorbose PTS system, IIB component","Cytoplasm, Periplasm","Several matches in gapped BLAST to sorbose PTS system, IIB components. Residues 1-153 are 34% similar to gi15900006 of S.pneumoniae. Residues 3-158 are 32% similar to gi16799100 from Listeria.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0361 (9e-15).","

InterPro
IPR004720
Domain

Phosphotransferase system, sorbose subfamily IIB component
PD008332	$\"[9-149]T$	PTSIIB_sorb
G3DSA:3.40.35.10	$\"[1-159]T$	PTS_IIB_sorb
PF03830	$\"[2-152]T$	PTSIIB_sorb
PS51101	$\"[1-163]T$	PTS_EIIB_TYPE_4
SSF52728	$\"[1-163]T$	PTS_IIB_sorb

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-148 are 30% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIB) protein domain (PD008332) which is seen in Q9RGG4_LACCA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 25 17:29:46 2005","Fri Dec 14 12:23:23 2001","Mon Jul 25 17:29:46 2005","Fri Dec 14 12:23:23 2001","","Fri Dec 14 12:23:23 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0089 is paralogously related (blast p-value < 1e-3) to SMu1707, and SMu1779, PTS components.","Fri Dec 14 12:39:42 2001","Mon Jul 25 17:29:46 2005","pdb1BLE Phosphoenolpyruvate-Dependent Phosphotransferase Sy... 77 1e-015","SMU.100","","Residues 2 to 152 (E-value = 2.3e-19) place SMu0089 in the PTSIIB_sorb family which is described as PTS system sorbose subfamily IIB component (PF03830)","Fri Dec 14 12:23:23 2001","24378621","","","Wehmeier,U.F. and Lengeler,J.W.Sequence of the sor-operon for L-sorbose utilization fromKlebsiella pneumoniae KAY2026Biochim. Biophys. Acta 1208 (2), 348-351 (1994)PubMed: 7947968","","Fri Dec 14 12:30:07 2001","1","","4","SMU.100","" "SMu0090","102284","103081","798","ATGTCAATAGAGTTTATTCAAAATATTTTAGTTATTTTATTGTCAGCCTACGTGGTAATGGATAATCTTGGAATTACAATTTTTAATTATTGGGCTGTAACAACAGGCATGCTTGTTGGTTTAATAATGGGGGATATCAATACAGGACTTTTAATTGGAGGGACTTTTCAATTAATGTCTTTAGGTGTTGCTGGGCTAGGCGGAGCTTCCGTTCCGGATTATGGACTTGCTGCTCTTGTTGGTACGTTTTTGGCAATTAGGACAGGATCGGGTTTGTCTACTGCGGTAGCAGTTGGCTTACCAGTAGGTTTATTAGCGATTAATTTTGATGTTTTAGTAAAAATTTTAAATAATTTTGTGGCACATAAAATGCAAAGATTAGCTCATGAAGGCAAATATAAACAAATGTTATTATGGGGTTGGATCGGACCAATAATGTTTATGTTAAAAAGTGTTATTATTGTCACTATTATTGTGACAGTAGGTCCAGGAGTTATCAAATCCATTTTAAATATTATTCCACAATGGGTTACAGATGGTTTAAATATTGCTGGTGGAATGTTACCGGTATTGGGGATTGCACTGTTATTACACTATATGCCTGCAAAGAAATACTTATGGGCAGTTTTAATAGGATTTGTACTTAGTACCTACTTAAAAGTTCCAATCATTGGGGTCTCAATTGTTGGTGCTGCAGCTGCAATTTTGATTTATCAAAGTAAAGCTGAAGAAATTGTTACTTCAAAAGAAAAAATGAGCTCTTTAAGCATTATTAATGAAGGAGATTATGATGAATAA","7.80","0.71","28236","MSIEFIQNILVILLSAYVVMDNLGITIFNYWAVTTGMLVGLIMGDINTGLLIGGTFQLMSLGVAGLGGASVPDYGLAALVGTFLAIRTGSGLSTAVAVGLPVGLLAINFDVLVKILNNFVAHKMQRLAHEGKYKQMLLWGWIGPIMFMLKSVIIVTIIVTVGPGVIKSILNIIPQWVTDGLNIAGGMLPVLGIALLLHYMPAKKYLWAVLIGFVLSTYLKVPIIGVSIVGAAAAILIYQSKAEEIVTSKEKMSSLSIINEGDYDE","103078","","sorbose PTS system, IIC component","Membrane, Cytoplasm","Similarities in gapped BLAST to sorbose PTS system, IIC components. Residues 1-222 are 39% similar to gi16802071 from L.monocytogenes and to gi16799101 from L.innocua. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0360 (3e-20).","

InterPro
IPR004700
Family

Phosphotransferase system, sorbose-specific IIC subunit
PF03609	$\"[3-237]T$	EII-Sor
PS51106	$\"[3-236]T$	PTS_EIIC_TYPE_4

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-102 are 35% similar to a (COMPONENT IIC SYSTEM PHOSPHOTRANSFERASE) protein domain (PD009389) which is seen in Q9CMJ1_PASMU.Residues 167-222 are 41% similar to a (COMPONENT IIC SYSTEM PHOSPHOTRANSFERASE) protein domain (PD010825) which is seen in Q9KIQ3_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 25 17:31:18 2005","Fri Dec 14 12:30:50 2001","Mon Jul 25 17:31:18 2005","Fri Dec 14 12:30:50 2001","","Fri Dec 14 12:30:50 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0090 is paralogously related (blast p-value < 1e-3) to SMu1708, and SMu1778, PTS components.","Fri Dec 14 12:40:10 2001","","No significant hits to the NCBI PDB database.","SMU.101","","Residues 3 to 237 (E-value = 4.8e-43) place SMu0090 in the EII-Sor family which is described as PTS system sorbose-specific iic component (PF03609)","Fri Dec 14 12:30:50 2001","24378622","","","Wehmeier,U.F. and Lengeler,J.W.Sequence of the sor-operon for L-sorbose utilization fromKlebsiella pneumoniae KAY2026Biochim. Biophys. Acta 1208 (2), 348-351 (1994)PubMed: 7947968","","Fri Dec 14 12:36:45 2001","1","","4","SMU.101","" "SMu0091","103071","103892","822","ATGATGAATAAAAAAGAAATTAATAATATTATTACAAAACGTGATCGTCACAATGCTATTCTCAGATGGATGTTCATGGGTTCAGCATTATATAACTATGAAACAGGGCAAGCAAGCTCAGTTGTTTGGTCCTTAGCTAAATTGCTAAGAAAAATATATCCAAATGATGAGGAATACAAAGAAGCATTGGATAATCATTTTAATTATTTTAATACAACGACTGCAATGGCAAATATTATACTTGGGGCAACAACTGCCATGGAAGAAAAGGATGGAATTCAAACTAAGGACGCAGTTAAATCATTAAAAACTTCTCTTATGGGACCTTTTGCAGGAATTGGGGACACCATTATCTGGGTTTTATTACCAACCATCATGGGTTCTATTTCGGGCTATATGGCAGTTAAAGGCAATCCTTTAGGTACGATTGCATGGATTATTATTGGAGCCCTTTTATTTTGGATACGTATTAAATTATTTGATATTGGTTATACATCAGGTGTGAAGTTAGTCACTAATTTCAGTGATAAGTTGTCTCTTTTTACAGAAGCCATGTCAGCTTTTGGTCTGATGGTTGTTGGAACATTGGTATCTACAGTCGTAAAAGTATATACGCCTTTAACTTTCAAGGCTGGGAAGGTAACCTTGTTAGTGCAAGAGAAAATTTTAGATGCTATTATGCCTTCCCTACTTGCAGTGGTGTTGACATATGTTGTTTACAAAATGCTTGAGTCTAAATGGTGGACGCCTACTAAAATAATTATGGCAATTATTATTGTTTCATTGCTAGGAGCATATACAGGAATTTTAGGTGTAAAATGA","10.30","8.47","30259","MMNKKEINNIITKRDRHNAILRWMFMGSALYNYETGQASSVVWSLAKLLRKIYPNDEEYKEALDNHFNYFNTTTAMANIILGATTAMEEKDGIQTKDAVKSLKTSLMGPFAGIGDTIIWVLLPTIMGSISGYMAVKGNPLGTIAWIIIGALLFWIRIKLFDIGYTSGVKLVTNFSDKLSLFTEAMSAFGLMVVGTLVSTVVKVYTPLTFKAGKVTLLVQEKILDAIMPSLLAVVLTYVVYKMLESKWWTPTKIIMAIIIVSLLGAYTGILGVK","103889","","PTS system, IID component","Membrane, Cytoplasm","Similarities in gapped BLAST to mannose-specific PTS IID components. Residues 6-271 are 36% similar to gi16799102 of L.innocua. Residues 2-262 are 34% similar to gi15902106 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1898 (1e-23).","

InterPro
IPR004704
Family

Phosphotransferase system, mannose/fructose/sorbose family IID component
PF03613	$\"[9-270]T$	EIID-AGA
PS51108	$\"[9-270]T$	PTS_EIID

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 11-270 are 26% similar to a (COMPONENT IID SYSTEM PHOSPHOTRANSFERASE) protein domain (PD013894) which is seen in P96164_VIBFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 25 17:32:09 2005","Fri Dec 14 12:41:08 2001","Mon Jul 25 17:32:09 2005","Fri Dec 14 12:41:08 2001","","Fri Dec 14 12:41:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0091 is paralogously related (blast p-value < 1e-3) to SMu1777, and SMu1709, PTS-related sequences.","Fri Dec 14 12:41:08 2001","","No significant hits to the NCBI PDB database.","SMU.102","","Residues 9 to 270 (E-value = 4.4e-63) place SMu0091 in the EIID-AGA family which is described as PTS system mannose/fructose/sorbose family IID component (PF03613)","Fri Dec 14 12:41:08 2001","24378623","","","Wehmeier,U.F. and Lengeler,J.W.Sequence of the sor-operon for L-sorbose utilization fromKlebsiella pneumoniae KAY2026Biochim. Biophys. Acta 1208 (2), 348-351 (1994)PubMed: 7947968","","Fri Dec 14 12:45:23 2001","1","","4","SMU.102","" "SMu0092","103889","104305","417","ATGATGGAAAGAAGAATCATCATAGCTTCTCATAATCATATGGCATCAGGTCTAAAAAGTACCATAGAATTTCTAGCTGGTATCCAGAATAATATAGTAACATTAGATGCCTATACTGATGGGAAACCGATTGGAGATAAAATCGAGAAAATTTTTAATGATTTTCCCCAAGAATGTGAAGTCGTTATTTTTACTGATTTACTCTCGGGATCTGTTAATCAAAAATTTTTTCCATATAGAGTTAGGGAACATGTACATCTGATAACAGGAATGAACTTACCTATTATTTTAGCCATGGTTTTGAATCATCAGGAAGTATATCTGGAAGAAGAACAGGTAAGTTATATGGTTCAGGAGGCGCGTTCATCATTAGTGTATGTAAATGAAATGAATTTAAATGATGAGGGGGATGAGTGA","4.60","-9.84","15788","MMERRIIIASHNHMASGLKSTIEFLAGIQNNIVTLDAYTDGKPIGDKIEKIFNDFPQECEVVIFTDLLSGSVNQKFFPYRVREHVHLITGMNLPIILAMVLNHQEVYLEEEQVSYMVQEARSSLVYVNEMNLNDEGDE","104302","","PTS system, IIA component","Cytoplasm","Similarities in gapped BLAST to PTS IIA components. Residues 2-105 are 33% similar to gi16767779 from S.typhimurium. Residues 5-138 are 26% similar to gi15900253 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1951 (1e-16).","

InterPro
IPR004701
Domain

Phosphotransferase system, fructose subfamily IIA component
G3DSA:3.40.50.510	$\"[3-134]T$	PTS_EIIA_fruc
PF03610	$\"[4-118]T$	EIIA-man
PS51096	$\"[3-124]T$	PTS_EIIA_TYPE_4
SSF53062	$\"[3-128]T$	PTS_EIIA_fruc

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-130 are 26% similar to a (SYSTEM PTS N DOMAIN) protein domain (PD009343) which is seen in Q9KIQ1_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 25 17:32:43 2005","Fri Dec 14 12:46:10 2001","Mon Jul 25 17:32:43 2005","Fri Dec 14 12:46:10 2001","","Fri Dec 14 12:46:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0092 is paralogously related (blast p-value < 1e-3) to SMu1707, a predicted ptnA sequence.","Fri Dec 14 12:50:50 2001","","No significant hits to the NCBI PDB database.","SMU.103","","Residues 4 to 118 (E-value = 1.1e-05) place SMu0092 in the EIIA-man family which is described as PTS system fructose IIA component (PF03610)","Fri Dec 14 12:46:10 2001","24378624","","","","","","1","","4","SMU.103","" "SMu0093","104305","106500","2196","ATGGAAAAAATAATTAGAGAAGGTTCAGTACGCTTTTCAATTATTACAAATTCACTTCTAAGAATTGAGGAAGATATTGAAAAAGTATTTGAAGATCGTCCTTCAACAACAGTACTAAATCGTTCCTTTGGAGAAGTTAATGCGGAGATAATCCGAAATCATAATAATCATATCTTGGAAATAGTGACTCCCTCGTTTCACTTGTATTATGATGGTGGCTCTCTATCTCCAATATCATTATACGTAGATATTAAAAAGTCCAGTTCTCTTTATCATAATAGATGGTTTTTTGGTAAGAAAAATGGGACAAAAAATCTTAAGGGGACTGTCAGAACTTTGGATCGTGCCGATGGTGAAGTTCCTCTGGAAGACGGTCTTATGTCTAAAGATGGTTTTAGTTCTTTAGATGATTCAACAAATTTTTTATATATAAAAGACTCAGATTCATTTGTGGCAAGAAGAAAGGGAACGGTAGATTTATACCTATTTTGCTATGGGAGGGATTATCAAGATGAGTTAACTGATTTTTATCGCTTAACTGGTTTTCCGCCGATGTTACCAAGATTTGCTCTTGGCAATTGGTGGAGCAGATTTTTCCCCTACACACAAGACGGATATATAGAATTGATGCGCCAATTTAATAAGAGGCTAATACCAATCAGTGTTTCAGTTCTAGATATGGACTGGCATAGAAGAAAAATTCCTCAAAAATACGGTTCGGGATGGACGGGGTATTCATGGAATAGAGATTTATTTCCAAACCCTAAAGAATTTATAGACTGGCTTCATACTGATGGGAAAAAAGTAGCTCTAAATGTACATCCAGCGGCAGGGATTCGTGCATTTGAAGATCAGTATAAAGAGGTTGCTAAAAGACTTCGCTTAAATGTAGATACTGAAGAGCCTGCAACCTTCGATTTGGAGGATGAAACATTTAGAAAAGTTTACTTTGAAAATATTCATCATCCCTTAGAAAGAGAAGGAGTAGATTTTTGGTGGATTGATTGGCAACAAGGAGCAGCAAAAACACTAGATAAGATGGATCCATTATGGTTATTAAATTACTATCATTATGAAGATAATAAAAAGTCGCATAATGGTGGATTAACGTTAAGTAGATATGCTGGACCGGGCTCTCATCGGTATCCCGTGGGGTTCTCGGGTGATACAGTGATTTCTTGGGACTCTCTATCATTTCAACCGTATTTTACAAGTACGGCGGCAAACATTGGTTACACTTGGTGGAGTCACGATATTGGAGGCCATATGAAAGGTCGTTTTGATGGAGAATTGGCTACAAGATGGATCCAATTTGGCGTGTTTAGCCCGATTAATCGTCTGCATTCTTCAGATAATAGATTTTCTGGAAAAGAACCTTGGAATTATGGAAGAGATTTTGAAGAGGCGCAAGAATATTTTTTAAGATTGAGGGCTAAGTTGATACCTTATATTGATACAGCTAATTATAAAACACATGCTTTTGGTATACCAATAAACAGACCCTTATATTATGAATGGCCCGAACAAGAAAAGGCTTATCAGTTTAAGAATGAATATCTATTTGGTTCTGAAATGATTGTTTCTCCAATTACAAGACCGCATGATAAAGTAACACAAAGCTCCTTTAGCGAAACATGGCTTCCAAAAGGCGAGTGGGTTGATTACTTCACACATCTTGTATATAAAGGAAATACTGTTATTAAGACCTATCGTAATTTAGATAGCTTTCCTGTGTTTGTTAGAAAAGGCAGTATCATTGTCACCAATCAAAATTATATGTCTTATGCTGATGTACTACCTGATAAGATCAATATTGAGATATTTACAGGCAAAGATGCTGCTTTTGATCTCTATGAAAATAGTCAAGGAACTGTGGCAAAAACGTCATTTAATTGGAATGAGGCATCTCAAAAATTAGATATTATTGTAGATGATCCTCATAAAATAATTCCTAAGACGAGAACCTTTAGTAAGACTATACACAAATTTCATATTGATGATGTTTTTGATGAAATTGACAAACGTTTAAAACAGGCATATACTGAATTTAATTTAAAACAACAGATATATGATGCTTTTATCGATTGTGATTATGAATACGGAAGTTTCATAAATCTACTAAATACAGTGGAGGATATAGATTTACGCAATAGTATAAGTGAGATAGCTTATATTAGAGAATCTTATAATAAATAA","6.30","-7.96","85704","MEKIIREGSVRFSIITNSLLRIEEDIEKVFEDRPSTTVLNRSFGEVNAEIIRNHNNHILEIVTPSFHLYYDGGSLSPISLYVDIKKSSSLYHNRWFFGKKNGTKNLKGTVRTLDRADGEVPLEDGLMSKDGFSSLDDSTNFLYIKDSDSFVARRKGTVDLYLFCYGRDYQDELTDFYRLTGFPPMLPRFALGNWWSRFFPYTQDGYIELMRQFNKRLIPISVSVLDMDWHRRKIPQKYGSGWTGYSWNRDLFPNPKEFIDWLHTDGKKVALNVHPAAGIRAFEDQYKEVAKRLRLNVDTEEPATFDLEDETFRKVYFENIHHPLEREGVDFWWIDWQQGAAKTLDKMDPLWLLNYYHYEDNKKSHNGGLTLSRYAGPGSHRYPVGFSGDTVISWDSLSFQPYFTSTAANIGYTWWSHDIGGHMKGRFDGELATRWIQFGVFSPINRLHSSDNRFSGKEPWNYGRDFEEAQEYFLRLRAKLIPYIDTANYKTHAFGIPINRPLYYEWPEQEKAYQFKNEYLFGSEMIVSPITRPHDKVTQSSFSETWLPKGEWVDYFTHLVYKGNTVIKTYRNLDSFPVFVRKGSIIVTNQNYMSYADVLPDKINIEIFTGKDAAFDLYENSQGTVAKTSFNWNEASQKLDIIVDDPHKIIPKTRTFSKTIHKFHIDDVFDEIDKRLKQAYTEFNLKQQIYDAFIDCDYEYGSFINLLNTVEDIDLRNSISEIAYIRESYNK","106497","","glycosyl hydrolase, alpha-glucosidase","Cytoplasm, Extracellular","Similarities in gapped BLAST to glycosyl hydrolases and to alpha xylosidase. Residues 3-728 are 43% similar to gi15902328 of S.pneumoniae. Residues 62-728 are 44% similar to gi15900245 of S.pneumoniae.SMu0093 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000322
Family

Glycoside hydrolase, family 31
PTHR22762	$\"[30-625]T$	Glyco_hydro_31
PF01055	$\"[161-586]T$	Glyco_hydro_31

noIPR
unintegrated

unintegrated
PTHR22762:SF3	$\"[30-625]T$	PTHR22762:SF3
SSF51445	$\"[179-337]T$	SSF51445

","BeTs to 3 clades of COG1501COG name: Alpha-glucosidases, family 31 of glycosyl hydrolasesFunctional Class: GThe phylogenetic pattern of COG1501 is ----y-v-E------------Number of proteins in this genome belonging to this COG is 1","***** IPB000322 (Glycoside hydrolase family 31) with a combined E-value of 1.8e-08. IPB000322C 244-269 IPB000322D 367-393 IPB000322E 408-449","Residues 156-624 are 27% similar to a (HYDROLASE GLYCOSIDASE GLYCOPROTEIN ALPHA-GLUCOSIDASE) protein domain (PD001543) which is seen in Q9F234_BACTQ.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:21:39 2002","Thu Apr 25 14:47:08 2002","Mon Jul 25 17:33:48 2005","Thu Apr 25 14:47:08 2002","Fri Dec 14 12:58:07 2001","Fri Dec 14 12:58:07 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0093 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 13:12:22 2001","","No significant hits to the NCBI PDB database.","SMU.104","","Residues 28 to 676 (E-value = 2.5e-08) place SMu0093 in the Glyco_hydro_31 family which is described as Glycosyl hydrolases family 31 (PF01055)","Fri Dec 14 12:58:07 2001","24378625","","","","","","1","","4","SMU.104","" "SMu0094","106501","107499","999","ATGAAAAGAAATCCTACAATCAATGATGTAGCTCAACTGGCTAATGTCAGTCGAGGAACTGTATCAAACTATATCAATGGTATTACTATTCGAGAAGAGAACAAGGCTAAAATTGAAAAAGCAATTGCAGAGTTGAAATATGTTCCCAATGCTAGAGCTCGGGAGTTAAAAACATCAAAAACATCGACTGTTGTGCTAATTGTACCAACGACGTGGAGTCCTTTTTTTGCAGAGTTGGTTTATAGAATGCAAGTTGAATTGGATCGAATTGGTTTTAAAATGATATTGGCCAATTCTCATGCAGATCCTGATGAAGAAGAAGAAATTCTTCGCATGGCATCCTTGAATCAGGTTACAGGTGTGATTACGATGTCCTATTCCAATATTTATAATTTCATAAATATTGGGAAGAAATTAAATTTGGTTTCCATTGAACGTTTTATTTCAGAAGATGTCCCTCTTATTACCAGTGATAATTATGGTGGAGGTCAATTAGCTGCTGAGAAATTGATCACATTTGGTTCAAAACGGTTCTTACTTTTGAGAAGAAAAACAAATCATTATAATGCGACTGATAAACGGACAGAAGGTTTTTTACATATTATGAAAGAAAATAATCTTCCTGTTGACATTTTTGAGGCTTCTTTAAAAGAGAATTATATTGAAGAATTTATCCATTATTTGAAAACTCATTTTTCTGGAGATGTCTTAACTTTTGATGGCATATTTGGTGTAACTGATGAATATGCTGTCATTGCTAAACAAGTGCTTTTTGAGCTAAATCCCTCTTATTTAAACAAAGTGAACATTATAGGGTTTGATGGCTCAAAGTCGCAAGAAAAAGGCAGTTATCAAATTGCTTCCATTAGGCAGCCAGTGGAAGCAATGGTGAAGGCAGCTGTCAAAGTTTTAAAAAAGTTAATTGATGGCGAGGAGGTTCCAAGTCATTATAGTAAGGTATTTGATGTTAGTTTTGTTGAGCCTGAAAGGTTAGTGTAA","7.20","0.47","37572","MKRNPTINDVAQLANVSRGTVSNYINGITIREENKAKIEKAIAELKYVPNARARELKTSKTSTVVLIVPTTWSPFFAELVYRMQVELDRIGFKMILANSHADPDEEEEILRMASLNQVTGVITMSYSNIYNFINIGKKLNLVSIERFISEDVPLITSDNYGGGQLAAEKLITFGSKRFLLLRRKTNHYNATDKRTEGFLHIMKENNLPVDIFEASLKENYIEEFIHYLKTHFSGDVLTFDGIFGVTDEYAVIAKQVLFELNPSYLNKVNIIGFDGSKSQEKGSYQIASIRQPVEAMVKAAVKVLKKLIDGEEVPSHYSKVFDVSFVEPERLV","107496","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu1359 (lacC); SMu1354 (lacX);SMu1355 (lacG); SMu1356 (lacE); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE).For other 'scr' genes see SMu1676 (scrK); SMu1677 (scrA); SMu1678 (scrB) and SMu1679 (scrR).","SCR operon transcriptional repressor","Cytoplasm","This sequence corresponds to the previously published gi|1184967 and gi|2495406 in GenBank. See also gi|2155300, gi|2323342,gi|2495405.Similarities in gapped BLAST to sucrose operon regulatory protein, e.g. residues 2-313 are 33% similar to gi|15903663 of S.pneumoniae. Residues 2-327 are 30% similar to the LacI family sequence of S.pneumoniae (gi|15901628).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1692 (2e-30).","

InterPro
IPR000843
Domain

Bacterial regulatory protein, LacI
PR00036	$\"[6-16]T$ $\"[16-26]T$	HTHLACI
PF00356	$\"[5-27]T$	LacI
SM00354	$\"[4-73]T$	HTH_LACI
PS00356	$\"[7-25]T$	HTH_LACI_1
PS50932	$\"[5-58]T$	HTH_LACI_2

InterPro
IPR001761
Domain

Periplasmic binding protein/LacI transcriptional regulator
PF00532	$\"[61-199]T$	Peripla_BP_1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[5-59]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[5-61]T$	G3DSA:1.10.260.40
G3DSA:3.40.50.2300	$\"[62-197]T$	G3DSA:3.40.50.2300
SSF53822	$\"[60-325]T$	SSF53822

","BeTs to 3 clades of COG1609COG name: Transcriptional regulators of the LacI familyFunctional Class: KThe phylogenetic pattern of COG1609 is ------V-EBrH---------Number of proteins in this genome belonging to this COG is 5","***** IPB000843 (Bacterial regulatory protein, LacI family) with a combined E-value of 1.9e-23. IPB000843A 6-26 IPB000843B 30-68","Residues 66-122 are 40% similar to a (TRANSCRIPTION REGULATION DNA-BINDING REPRESSOR) protein domain (PD353269) which is seen in SCRR_STRMU.Residues 141-277 are 27% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000591) which is seen in SACR_LACLA.Residues 6-79 are 42% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000947) which is seen in CCPA_BACSU.Residues 5-122 are 32% similar to a (TRANSCRIPTION REPRESSOR REGULATION) protein domain (PD023303) which is seen in O07567_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:39:26 2002","Fri Dec 14 13:20:51 2001","Thu Oct 24 10:42:47 2002","Thu Apr 4 10:44:41 2002","Fri Dec 14 13:13:24 2001","Fri Dec 14 13:13:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0094 is paralogously related (blast p-value < 1e-3) to SMu1679, SMu1446, SMu1424, and SMu0807, lacI family and related sugar operon repressors.","Fri Dec 14 13:23:10 2001","","No significant hits to the NCBI PDB database.","SMU.105","","Residues 5 to 30 (E-value = 4.8e-05) place SMu0094 in the LacI family which is described as Bacterial regulatory proteins, lacI family (PF00356)","Fri Dec 14 13:13:24 2001","24378626","","Hiratsuka,K., Wang,B., Sato,Y. and Kuramitsu,H.Regulation of sucrose-6-phosphate hydrolase activity inStreptococcus mutans: characterization of the scrR geneInfect. Immun. 66 (8), 3736-3743 (1998)PubMed: 98339875Simpson,C.L. and Russell,R.R.Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutansInfect. Immun. 66 (5), 2085-2092 (1998)PubMed: 98234037","Bell CE, Lewis M.Crystallographic analysis of Lac repressor bound to natural operator O1.J Mol Biol. 2001 Oct 5;312(5):921-6.PMID: 11580238 ","Thu Apr 4 10:44:41 2002","Fri Dec 14 13:20:51 2001","1","","4","SMU.105","" "SMu0095","107970","107734","237","ATGACCGAGCCATTCCATCAGGATGATATGGTGATCAGGGATAGCTTTCCCATACCTGTTTGTTTACCAGCTCGCAACGACAAGGTTCGTAGTTTTAGAGATCAAGCAACTGTGGCCTACAATCCTCCAAAAAAGATGTGCTTTTACGGCTTTAAAGCCCATATGCTGGTGACCTTGTCAGGATTTATTGTCAATTATGGTGTGACGCCAGCCTCTGTATTGGAGGCTCAAGGCTGA","8.10","1.37","8749","MTEPFHQDDMVIRDSFPIPVCLPARNDKVRSFRDQATVAYNPPKKMCFYGFKAHMLVTLSGFIVNYGVTPASVLEAQG","107737","","transposase fragment","Periplasm, Cytoplasm","This sequence is related to the previously published gi|13897502 in S.mutans. Residues 1-77 are 77% similar to gi|13897502. See also gi|15383627 and gi|6716559.SMu0095 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[53-73]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 14-73 are 56% similar to a (TRANSPOSASE PLASMID PROTEASE TRASNPOSASE) protein domain (PD013353) which is seen in Q9L9Q9_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:24:25 2002","Fri Dec 14 13:29:32 2001","Fri Dec 14 13:30:45 2001","Fri Dec 14 13:29:32 2001","","Fri Dec 14 13:29:32 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0095 is paralogously related (blast p-value < 1e-3) to SMu0205, SMu1213, and SMu0084, transposase fragments.","Fri Dec 14 13:30:45 2001","","No significant hits to the NCBI PDB database.","SMU.106c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 13:29:32 2001","24378627","","","","Tue Oct 8 17:24:25 2002","","1","","4","SMU.106c","" "SMu0096","109108","109278","171","TTGGAACTAGAACAAATAAGAGATTTTGAAAAAGCTCAATCAAATAATGATATAAATGATTTTTTTAATTATGCTTACTCAAAAGTATATTCAGAATTGTTAAATGTAGAATTAGAATCACAAATTAGTTTTTTGAAGAATAATTATTTTAAAAGCCACTTCGAAAAATGA","4.50","-3.77","6784","MELEQIRDFEKAQSNNDINDFFNYAYSKVYSELLNVELESQISFLKNNYFKSHFEK","109275","","hypothetical protein","Extracellular, Cytoplasm","No significant matches in gapped BLAST.SMu0096 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:24:42 2002","Fri Dec 14 13:32:46 2001","Fri Dec 14 13:32:46 2001","Fri Dec 14 13:31:31 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0096 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 13:31:31 2001","","No significant hits to the NCBI PDB database.","SMU.107","","No significant hits to the Pfam 11.0 database","Fri Dec 14 13:31:31 2001","24378628","","","","","","1","","","SMU.107","" "SMu0097","109280","109417","138","ATGACTATTTTAGATTTATGTTGTGGTACTGGTCGACATGTAAAAAAATTAAATGATGAAGATTACATGGTGGATGGTGTTGATATAAATCCCGAAGCAGTAAATACTGCTCAAAAATCAATAATAAACAATAAATGA","4.80","-1.87","4960","MTILDLCCGTGRHVKKLNDEDYMVDGVDINPEAVNTAQKSIINNK","109414","","hypothetical protein","Cytoplasm, Extracellular","No significant matches in gapped BLAST.SMu0097 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001579
Active_site

Glycoside hydrolase, chitinase active site
PS01095	$\"[24-32]?$	CHITINASE_18

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[1-39]T$	G3DSA:3.40.50.150
SSF53335	$\"[1-39]T$	SSF53335

","BeTs to 8 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class:� RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","***** IPB001566 (RNA methyltransferase trmA family) with a combined E-value of 8.9e-08. IPB001566A 3-44***** IPB000339 (ubiE/COQ5 methyltransferase family) with a combined E-value of 7e-07. IPB000339B 2-16 IPB000339C 23-40","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:25:01 2002","Fri Dec 14 13:33:53 2001","Tue Oct 8 17:25:01 2002","Fri Dec 14 13:33:53 2001","Fri Dec 14 13:33:53 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0097 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:25:01 2002","","No significant hits to the NCBI PDB database.","SMU.108","","No significant hits to the Pfam 11.0 database","Fri Dec 14 13:33:53 2001","24378629","","","","","","1","","","SMU.108","" "SMu0098","109582","110682","1101","ATGTTCAATTTTTTCAAGAAAAATAAACTCTTCACTCAACTTGCTAGCATTAATTTCGTATCAAAGATTGGAGATAAACTATTCTATACAGCAATGCTAACGACAGCAACCTCTCTTCCAGATGGAAGCATAGCAGTTATGGTAGTATCAGCTTCAGAAACTCTTCCTATCTTAATTAGTTTATTTTTAGGTGTAGTAGCTGATAGACAAAGGCAAAAACTAAAACACTTGATAGGCAGTTCTCTTTTCAGAGCAGTCATGTATATCAGTATAGGATTTATTTTTAAATACCCTCCAACTTTACTTTTAGTTATATTTGCCTCCTTATTAAATCTGCTTTCTGATATTAGTGGGAATTACTCAACGGCGCTATTTTCACCTTTTACTAAAATACTGATTAAATCAGAAGATATGGAAGAAGCACAGGGTTTTATCAGTGTTGGGACACAACTAGTTACCGTTTTTGCAACTTTTATTGGTGCATCATTGCTAACCATTTATACAGAGAGTTCATTAGCGATGCTAAATGCCCTCATTTTCCTAATTGTTACCTTGCTTTACTGGTCGGTTAAGTCGCCTCTAAAAAAACAAGAAGACAAACTAAAAATAGTTGAACACGAGAAGACATTCTTAGTTGTTAAAGAAAATTTACGTTCTTTTCTATCTGACAATATATTGCTCATTAATCTCATTCAATTAGCAATGCTTAATGGATTTTTTGGAGGTTTAACTCCTATATTTGCTCTATTTATAAAAAGCAATAATGAACTAGTTCTGTTAAGTAATCCTGTTAAGATTTCTCTCTTATCAGGAATTATGACATTATCTATGATACTTGGAAATAGCCTAACATCAAAAATTCTTAGAAAATATTCTATTTTTCATATCAATGTATGGTCTGACGTGATGATTCTTCTAATAGGTATTGGTTTTAATCTTAATAGTATTTGGATAATCTTCTTAGCTAATAGTAGTCTTGCCTTCTTATTAGGAATTGTTGCCCCAAGATTTTCTGCTGATGTGGTTAATCGTTACCCAGTCGAAAGAATTGGTGGAATTATTACAACTGTTAACGCTCTCTTAGTAATAGCCCCCCATTAA","10.40","9.96","40495","MFNFFKKNKLFTQLASINFVSKIGDKLFYTAMLTTATSLPDGSIAVMVVSASETLPILISLFLGVVADRQRQKLKHLIGSSLFRAVMYISIGFIFKYPPTLLLVIFASLLNLLSDISGNYSTALFSPFTKILIKSEDMEEAQGFISVGTQLVTVFATFIGASLLTIYTESSLAMLNALIFLIVTLLYWSVKSPLKKQEDKLKIVEHEKTFLVVKENLRSFLSDNILLINLIQLAMLNGFFGGLTPIFALFIKSNNELVLLSNPVKISLLSGIMTLSMILGNSLTSKILRKYSIFHINVWSDVMILLIGIGFNLNSIWIIFLANSSLAFLLGIVAPRFSADVVNRYPVERIGGIITTVNALLVIAPH","110679","","lantibiotic related antibiotic efflux protein/macrolide permease","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 1-365 are 27% similar to gi15902188 of S.pneumoniae. Residues 7-346 are 22% similar to gi11178682 of S.gordonii.SMu0098 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PTHR10074	$\"[5-291]T$ $\"[343-364]T$	PTHR10074
PTHR10074:SF7	$\"[5-291]T$ $\"[343-364]T$	PTHR10074:SF7
SSF103473	$\"[1-364]T$	SSF103473

","BeTs to 6 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 7-346 are 22% similar to a (PLASMID DSG) protein domain (PD216156) which is seen in Q9F2I5_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 20 12:26:27 2007","Fri Mar 16 11:16:18 2007","Tue Feb 20 12:26:27 2007","Tue Feb 20 12:26:27 2007","","Fri Dec 14 13:34:30 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0098 is paralogously related (blast p-value < 1e-3) to SMu1221, a possible permease.","Fri Dec 14 13:39:04 2001","","No significant hits to the NCBI PDB database.","SMU.109","","No significant hits to the Pfam 11.0 database","Fri Dec 14 13:34:30 2001","24378630","","","","","","1","","","SMU.109","" "SMu0099","111684","110824","861","TTGACTAAATTAGACTCGTTTCATTTAGGAGAGCTTTATAGAGAACTGCGAGTAGCTAGAGGTCTGAAAATGAAAGATGTAGTTAGTGATAAATTGTCGCAGGCACAATTATCTAAATTTGAAAACGGACAAACGATGTTGTCAGCGGATAAATTATTGACTGCAATATCGGCTATACACATGAGTTTTGCTGAATTTGAGCATGCGTACTATCAATATGAAGACAGTTCCTTTTTTAAACAAGCTAAGTTAATTTCCAAATACCATTCAAATAAAAATATTGAAGGTCTTGAAAAGCTTCTAATAATTCATGATAATAATTCCGAAACTTATGATGTCTATGATAAACTTAATAAACTTGTTATTCGTTGTGCTATTCATGATTTAAACCCAGAATACATTATCTCAGACGACGATAAAGATTTCATTACAACTTACCTTTATAGCATTGAAGAGTGGACAGAATATGAATTGTACATTTTTGGCAATACTTTACAAGTATTATCAGATAGTGACCTTATATTTCTTAGCAAGTCTTTTATAGAAAGAGATTCATTATACTTGTCCATTCCAAATAATAACTTTCGGACTCAATTAGTTGTTCTAAATATTATCTTTGTGCTATTAGAGAGGAAAAAAGATTATTGTGTTCACTATTTTATGAAACACCTAGAATCTATTCTGACTTATCAAGACATGTTTGTAAAGACCGTACTTATATTTTTAAAAAAAGTTTTAAACTATCGAGAAGGAAAAGGGACTCATTTAATAGATTTAAAAAAATATATTCATGATGTTGAAGAGCTAGGGCATGAAGATGTTGCAGAATTTCTCAAAGATAATATTGTTAATCTACTATAA","5.60","-8.43","33648","MTKLDSFHLGELYRELRVARGLKMKDVVSDKLSQAQLSKFENGQTMLSADKLLTAISAIHMSFAEFEHAYYQYEDSSFFKQAKLISKYHSNKNIEGLEKLLIIHDNNSETYDVYDKLNKLVIRCAIHDLNPEYIISDDDKDFITTYLYSIEEWTEYELYIFGNTLQVLSDSDLIFLSKSFIERDSLYLSIPNNNFRTQLVVLNIIFVLLERKKDYCVHYFMKHLESILTYQDMFVKTVLIFLKKVLNYREGKGTHLIDLKKYIHDVEELGHEDVAEFLKDNIVNLL","110827","While Smu1371 and Smu0099 are similar to MI0001, a MutR, they are not embedded in a mutacin operon and therefore probably have a different transcriptional role.","transcriptional regulator","Cytoplasm","This sequence has been previouisly published in GenBank as gi5918757, gi9801995, gi12082656 a predicted mutR. Residues 6-286 are 57% similar to gi5918757. Residues 4-269 are 39% similar to gi15902184 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0239 (1e-28).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
SM00530	$\"[12-66]T$	HTH_XRE

InterPro
IPR010057
Domain

Transcriptional activator Rgg/GadR/MutR, C-terminal
TIGR01716	$\"[68-285]T$	RGG_Cterm: transcriptional activator, Rgg/G

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 233-286 are 44% similar to a (MUTR) protein domain (PD051162) which is seen in Q9ZAB4_STRMU.Residues 10-178 are 25% similar to a (PROTEOME COMPLETE REGULATOR) protein domain (PD403282) which is seen in Q9CF12_LACLA.Residues 9-258 are 20% similar to a (PLASMID) protein domain (PD126552) which is seen in O50343_LACHE.Residues 6-232 are 61% similar to a (REGULATOR PROTEOME TRANSCRIPTION COMPLETE) protein domain (PD039813) which is seen in Q9RPM0_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu May 5 11:20:25 2005","Tue May 3 12:22:33 2005","Wed Apr 27 10:43:54 2005","Fri Dec 14 13:39:46 2001","","Fri Dec 14 13:39:46 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0099 is paralogously related (blast p-value < 1e-3) to SMu1371, a predicted rgg regulatory element. Both Smu0099 and Smu1371 are similar to MI0001 from strain UA140.","Wed Apr 27 10:43:54 2005","","No significant hits to the NCBI PDB database.","SMU.110c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 13:39:46 2001","","","","","Thu May 5 11:20:25 2005","","1","","","SMU.110c","" "SMu0100","112694","111945","750","ATGAAAAATAACAAGAAATTAACCGAAACAGAAGAATACACTTGGCAATACATCACCCGTGATTTCAATGAGATTGGGAAATTAAATATTTCTGAACTGAGTCAAGCTATTAATGTTTCAAATGCAACCATCATTAGAACGCTTAAGAAAAAAGGATATGGCGGTTTTTCAGAATTTAAACACGAAATAGAACAAAAGAAAAATAACAGCCTGCACGTGTTAACTAATAAATCTTTAAAAAAAGATACCAGACGTTCCATCATTAAAAATTATCAAGAAGTCATGCGGACACTTAATACGCTGGATGTTACCGCCATAGAAGAAAGTATTTTAATGATTGAAAAGGCACAGCGCATTATTATCTTTGCTAGGGGATTTTCAGAACTTATCGCTTCTGAAATGCTCGTCAAATTTCAGTTGCTCAATAAATACTGCGAATTACATACTGACCCTAATATTATTCGCCCAGTCAGTGCACGGTTAACATCAAAAGATCTTGTTCTTTTTATTTCCCTTAATGGCGAAACGGTTGCTTTGGTTGATGCTGCTAGAAATTGCATTAAAAATAGGGTTAAAACCATTTTATTGAGCGCTAGTGAAAGCAGTTCTCTAGCTCATTTAACCTCACTACAATTAATAGGTTTTAAAACAGAACTGTCTTACTTTCCAGACTATGAAGTTCACTCACGCTTACCACTTTCTATCCTTTCGCGCATTCTCCTAGATGCTTATGCCGCTAGTTTAAATTGA","10.00","8.12","28372","MKNNKKLTETEEYTWQYITRDFNEIGKLNISELSQAINVSNATIIRTLKKKGYGGFSEFKHEIEQKKNNSLHVLTNKSLKKDTRRSIIKNYQEVMRTLNTLDVTAIEESILMIEKAQRIIIFARGFSELIASEMLVKFQLLNKYCELHTDPNIIRPVSARLTSKDLVLFISLNGETVALVDAARNCIKNRVKTILLSASESSSLAHLTSLQLIGFKTELSYFPDYEVHSRLPLSILSRILLDAYAASLN","111948","","transcriptional regulator, RpiR family","Cytoplasm, Membrane","Similarities in gapped BLAST to transcriptional regulators and to conserved hypothetical proteins. Residues 7-245 are 31% similar to gi4206184 of L.lactis. Residues 5-221 are 23% similar to gi15903561 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0042 (2e-13).","

InterPro
IPR000281
Domain

Helix-turn-helix protein RpiR
PF01418	$\"[17-60]T$	HTH_6
PS51071	$\"[1-70]T$	HTH_RPIR

InterPro
IPR001347
Domain

Sugar isomerase (SIS)
PF01380	$\"[112-208]T$	SIS

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10490	$\"[70-244]T$	G3DSA:3.40.50.10490
SSF46785	$\"[11-81]T$	SSF46785
SSF53697	$\"[77-249]T$	SSF53697

","BeTs to 3 clades of COG1737COG name: Transcriptional regulators, RpiR familyFunctional Class: KThe phylogenetic pattern of COG1737 is ------V-EB-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB000281 (Helix-turn-helix domain, RpiR family) with a combined E-value of 3e-07. IPB000281B 150-197","Residues 106-182 are 35% similar to a (PROTEOME COMPLETE AMINOTRANSFERASE ISOMERASE) protein domain (PD000868) which is seen in Q9ZB19_LACLA.Residues 7-66 are 45% similar to a (PROTEOME TRANSCRIPTION COMPLETE REGULATOR) protein domain (PD211848) which is seen in Q9ZB19_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:26:53 2002","Tue Oct 8 08:02:55 2002","Thu Sep 28 09:01:41 2006","Tue Dec 4 11:18:08 2001","Tue Dec 4 11:18:08 2001","Tue Dec 4 11:18:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0100 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 13:55:57 2001","","No significant hits to the NCBI PDB database.","SMU.112c","","Residues 2 to 98 (E-value = 9.3e-05) place SMu0100 in the HTH_6 family which is described as Helix-turn-helix domain, rpiR family (PF01418)","Tue Dec 4 11:18:08 2001","24378632","","","","","","1","","","SMU.112c","" "SMu0101","112823","113755","933","ATGGGAATTTATACTTGTACCATGAATTTAGCCATTGATTTATTTATTGAGACAGAACACCTGTATGAGTCTAAGGTTAATCGTGCTTTATCAGATGATATTCAGGCAAATGGGAAGGGCGTTAATGTGTCTTTTATTATGAAAAGACTTGGGCTTGAGAACACTGCTCTTGGTTTTTCGGGAGGTTTTACAGGAAAATATGTCGCAGACAATTTAGAAGCTGAAGGGATAGCTGCCCCTTTTGTTGAAGTAGAAGGACTGACACGAATTAATGTCTTTACTAAAGTAAATGCTACCTGTCAGGAATTTAAATTAGTCAATCAGGGACCTTTGGTCAATGAAGCTGCTCAATGCAGGCTATTACAGCAAATTTCTAAATTTAAAAAAGGAGATTATCTTGTTGTATCTGGCAGCCTACCCAGAGGTGTTCCATCGCAAATCCTATATGATATTGCTAAATTATGTTACGAAAAGGGTGTTAATCTTATTTTTGATGTGAGTGATTGTATCATTATGGATAGTTTGTCATTTCATCCTTTTTTGTTGAAACCAAATGAGGAGGAATTAGCTACTTGGTTTGGCAAAAATCAATTGGAAGAGGAACAATTGATTTCTTATGCTAAGCAATTAATTGTCAAGGGAGCACGTCATGTTCTTTTGTCCTTAGGACAAGATGGAGCTATTTTTATTGATTCTCACTTTAATGTCTATCAGGCTAATGCTCCTAGAGGAAAGGTGGTGAACACAGCCTGTGCAGGGGATACTTTATTGGGGACCTTTTTGGCAGGATTCATCAGACAGGAATCTTTAGAAAGGGTATTAGCAAAAAGTGTAGCTGCTGGTTCTTCAACGGCTTTTAGAAGTGGTATCACAGACTTTAGTGATGTCAATGAATTAAAAGAACAAATTATGGTCAAAAAAATAAAGGAGTAA","5.50","-4.31","34051","MGIYTCTMNLAIDLFIETEHLYESKVNRALSDDIQANGKGVNVSFIMKRLGLENTALGFSGGFTGKYVADNLEAEGIAAPFVEVEGLTRINVFTKVNATCQEFKLVNQGPLVNEAAQCRLLQQISKFKKGDYLVVSGSLPRGVPSQILYDIAKLCYEKGVNLIFDVSDCIIMDSLSFHPFLLKPNEEELATWFGKNQLEEEQLISYAKQLIVKGARHVLLSLGQDGAIFIDSHFNVYQANAPRGKVVNTACAGDTLLGTFLAGFIRQESLERVLAKSVAAGSSTAFRSGITDFSDVNELKEQIMVKKIKE","113752","","fructose-1-phosphate kinase","Cytoplasm","Similarities in gapped BLAST to fructose 1-phosphate kinase sequences. Residues 3-303 are 38% similar to gi|15613390 of B.halodurans. Residues 3-305 are 37% similar to gi|15923689 of S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1347 (1e-46).","

InterPro
IPR011611
Domain

PfkB
PF00294	$\"[6-297]T$	PfkB

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.20	$\"[9-303]T$	no description
PTHR10584	$\"[7-297]T$	SUGAR KINASE RELATED
PTHR10584:SF37	$\"[7-297]T$	PHOSPHOFRUCTOKINASE(PFK1)

","BeTs to 6 clades of COG1105COG name: Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)Functional Class:� GThe phylogenetic pattern of COG1105 is ------v-Ebrh--gpo----Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 214-287 are 35% similar to a (KINASE RIBOKINASE PROTEOME COMPLETE) protein domain (PD291376) which is seen in K1PF_BORBU.Residues 218-292 are 37% similar to a (KINASE TRANSFERASE COMPLETE PROTEOME) protein domain (PD023180) which is seen in Q9RMF4_SPICI.Residues 218-295 are 35% similar to a (KINASE 1-PHOSPHATE TRANSFERASE) protein domain (PD278491) which is seen in FRUK_MYCGE.Residues 3-211 are 40% similar to a (KINASE TRANSFERASE 1-PHOSPHOFRUCTOKINASE) protein domain (PD005753) which is seen in Q9KEM5_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 12:42:25 2002","Fri Dec 14 13:57:26 2001","Fri Dec 14 14:00:27 2001","Fri Dec 14 13:57:26 2001","","Fri Dec 14 13:57:26 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0101 is paralogously related (blast p-value < 1e-3) to SMu0794, also a predicted fructose-1-phosphate kinase, and SMu1359, a predicted tagatose-6-phosphate kinase.","Fri Jan 11 12:42:25 2002","","No significant hits to the NCBI PDB database.","SMU.113","","Residues 8 to 297 (E-value = 8.7e-34) place SMu0101 in the PfkB family which is described as pfkB family carbohydrate kinase (PF00294)","Fri Dec 14 13:57:26 2001","24378633","","","Wang X, Kemp RG.Reaction path of phosphofructo-1-kinase is altered by mutagenesis and alternative substrates.Biochemistry. 2001 Apr 3;40(13):3938-42.PMID: 11300773Gay P, Delobbe A.Fructose transport in Bacillus subtilis.Eur J Biochem. 1977 Oct 3;79(2):363-73.PMID: 200418 ","","Fri Dec 14 14:08:13 2001","1","","","SMU.113","" "SMu0102","113760","115160","1401","ATGTCAGAATTTAAACTTATTGCAGCAACTGGCTGTCCTACTGGTATTGCCCATACGTTTATGGCACAAGAAGCTCTAGAACAGGCTGCCAAGGAAAAAGGTGTTTCTATTAAGGTTGAAACCCATGGACAAGTAGGAGTAGAGAATGAATTGACTCCTGCAGAAATAGCAGGCGCCAAAGCTGTTATTATTGCAGCCGACAAGGATGTTCAAGCAGAACGTTTTGCTGGAAAAAGAGTTATTGAAGTTTCTGTTGCTGATGGGATTAAAAAAGCAGACCAATTAATAGCAGATGCTTTAGCTGGCAAAGGACAAATTAAGGGCGGCACTAAAATAGAAAGTGCAGAGCTTTCTTCAGATACTGAGGGAGAAAGTTTTGGACGGCAAGTTTATAGACATTTAATGAATGGTGTTTCCCATATGTTACCGTTTGTTGTTGCTGGTGGTGTTTTGGTAGCCATTTCTTTCTTATTTGGTATCTATTCTTTTGATCCTAAAAGCGAACAATATAATTGGTTTGCAGCACTGCTGAAAACAGATATTGGTGGTGTTGCGATGGGCGTTATGACTCCTATTCTAGCGGCTTATATTGCAGAGTCTATTGCAAAACGCCCCGGCTTTGTTGCTGGTTTTGTTGGCGGCATGATGGCGGTGAATGGCGGCTCAGGCTTCTTAGGTGGTATTATCGCTGGTTTTGCTGCAGGTTACATTGTATTAGGTCTCATGAAACTGTTTGAAAAATTACCAAAATCATTGGATGGCTTAAAGGCAATCTTTTTGTATCCTGTATTTGGTGTCTTTTTGACAGGAATGGTTATGGCTGTTGTTAATTCACCTATGGCTTGGGTTAATAAGAGTTTAATGGCATGGCTAGGTGCTTTTGAAAATGCTAATCCATTGGTTCTTGGTGTTATTGTTGGCTGCATGTGTGCATTTGACATGGGTGGTCCTGTTAATAAAGCGGCTTATGTTACGGGTACGGCCCTACTTGCACAAGGAAATACAACCTTTATGGCTGGTGTATCAGCAGCATGCATTGCACCTCCACTCATTACTTTTGTTGCGACCACTGCTTTTAGAAAATATTATGATGAAAATGATCGTAATGCTGGTTTGGCAAATCTTATTTTAGGTTCCACTCATATTACCGAAGGGGCGATTCCTTTCGCGGCTAAAGATCCGCTTCGCATGTTACCAACCTTCATGCTGGGCTCATCTATTGCTGCTATCTTAACCTATATGTGGAAAGTTAAGGTCCCAGCGCCTCATGGTGGCTTTCTAGTTCTACCAGTTGTTACCCATGCCTTCCTTTGGGTTCTTGCTATTGCAATCGGTGCCATAGTAGCTGGTATTATTATGGGATTCATTCAAAAATCAAAATATGAAAAAGCAAGAGGTTAA","8.50","4.51","48893","MSEFKLIAATGCPTGIAHTFMAQEALEQAAKEKGVSIKVETHGQVGVENELTPAEIAGAKAVIIAADKDVQAERFAGKRVIEVSVADGIKKADQLIADALAGKGQIKGGTKIESAELSSDTEGESFGRQVYRHLMNGVSHMLPFVVAGGVLVAISFLFGIYSFDPKSEQYNWFAALLKTDIGGVAMGVMTPILAAYIAESIAKRPGFVAGFVGGMMAVNGGSGFLGGIIAGFAAGYIVLGLMKLFEKLPKSLDGLKAIFLYPVFGVFLTGMVMAVVNSPMAWVNKSLMAWLGAFENANPLVLGVIVGCMCAFDMGGPVNKAAYVTGTALLAQGNTTFMAGVSAACIAPPLITFVATTAFRKYYDENDRNAGLANLILGSTHITEGAIPFAAKDPLRMLPTFMLGSSIAAILTYMWKVKVPAPHGGFLVLPVVTHAFLWVLAIAIGAIVAGIIMGFIQKSKYEKARG","115157","","PTS system, fructose-specific IIBC component","Membrane, Cytoplasm","Several matches in gapped BLAST to PTS fructose-specific component IIB sequences. Residues 5-440 are 52% similar to gi|16766553 of S.typhimurium. Residues 4-429 are 48% similar to gi|15613391 of B.halodurans.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1346 (2e-97).","

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[135-404]T$	PTS_EIIC

InterPro
IPR003353
Domain

Phosphotransferase system, fructose-specific IIB subunit
PF02379	$\"[5-107]T$	PTS_IIB_fruc
TIGR00829	$\"[7-90]T$	FRU: PTS system, Fru family, IIB component

InterPro
IPR006327
Domain

Phosphotransferase system, fructose IIC component
TIGR01427	$\"[116-457]T$	PTS_IIC_fructo: PTS system, Fru family, IIC

InterPro
IPR013011
Domain

Phosphotransferase system, EIIB component, type 2
PS51099	$\"[6-101]T$	PTS_EIIB_TYPE_2

InterPro
IPR013014
Domain

Phosphotransferase system, EIIC component, type 2
PS51104	$\"[130-465]T$	PTS_EIIC_TYPE_2

InterPro
IPR013248
Family

Shr3 amino acid permease chaperone
SM00786	$\"[261-413]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[141-161]?$ $\"[180-198]?$ $\"[207-239]?$ $\"[258-276]?$ $\"[297-317]?$ $\"[339-359]?$ $\"[397-417]?$ $\"[436-456]?$	transmembrane_regions

","BeTs to 4 clades of COG1299COG name: Phosphotransferase system, fructose-specific IIC componentFunctional Class:� GThe phylogenetic pattern of COG1299 is --------EB-h--gpO----Number of proteins in this genome belonging to this COG is 2","***** IPB003353 (PTS system, fructose specific IIB domain) with a combined E-value of 1.2e-31. IPB003353 6-55***** IPB003474 (GntP family permease) with a combined E-value of 2.7e-06. IPB003474B 190-241 IPB003474C 315-350 IPB003474D 417-456","Residues 306-440 are 46% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD132278) which is seen in Q9CGY3_LACLA.Residues 5-87 are 55% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD004040) which is seen in Q9KEM4_BACHD.Residues 132-309 are 50% similar to a (COMPONENT SYSTEM PTS FRUCTOSE-SPECIFIC) protein domain (PD350819) which is seen in Q9KEM4_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:00:52 2002","Fri Dec 14 14:20:39 2001","Fri Dec 14 14:24:56 2001","Fri Dec 14 14:20:39 2001","Fri Dec 14 14:20:39 2001","Fri Dec 14 14:20:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0102 is paralogously related (blast p-value < 1e-3) to SMu0795, a PTS IIABC component.","Fri Dec 14 14:24:56 2001","","No significant hits to the NCBI PDB database.","SMU.114","","Residues 5 to 107 (E-value = 5.5e-50) place SMu0102 in the PTS_IIB_fruc family which is described as PTS system, Fructose specific IIB subunit (PF02379)Residues 135 to 404 (E-value = 7.8e-33) place SMu0102 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)","Fri Dec 14 14:20:39 2001","24378634","","","","","","1","","","SMU.114","" "SMu0103","115175","115627","453","ATGATTGATGAAAATCTGATAAAAATAAATTTGATATGTGAGTCTCAGGATGAGGTCTTCCACTATTTAGCAACTTTAGTTGTAGATAATGGCTACGCTAACAATACAGAATCCGTTGTTCAAGCTTTAAAATTGCGGGAGTCTGAAGGTACTACAGGCATGATGGAAGGCTTTGCCATTCCTCATGCCAAAGACAAAAGTATAGTTAAACCTAGTATTGCCATTTTAAAACTTAAGACGGGTGTTGAATGGCATTCCATGGACGGTCAATTAATTAATAATGTTATAGCACTCTTCATCCCTGAAAAGGAAGCAGGGACAACACATTTAAAAGTATTATCCCAAATAGCTCGTTTACTAGTGAATAAGACTTTTAAAGAAAAGATTAAAGAGGCTGACACTATTTTAGAATTAAAAGAGCTTTTAACTGAAAAATTAGATTTAACATCCTAA","5.40","-4.08","16732","MIDENLIKINLICESQDEVFHYLATLVVDNGYANNTESVVQALKLRESEGTTGMMEGFAIPHAKDKSIVKPSIAILKLKTGVEWHSMDGQLINNVIALFIPEKEAGTTHLKVLSQIARLLVNKTFKEKIKEADTILELKELLTEKLDLTS","115624","","PTS system, fructose-specific IIA component","Cytoplasm","Similarities in gapped BLAST to PTS system, fructose-specific IIA component proteins. Residues 1-122 are 36% similar to gi|16801307 of L.innocua and to gi|16804176 of L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1346 (4e-13).","

InterPro
IPR002178
Domain

Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PD001689	$\"[2-132]T$	Q8DWE6_STRMU_Q8DWE6;
G3DSA:3.40.930.10	$\"[1-144]T$	no description
PF00359	$\"[1-145]T$	PTS_EIIA_2
PS51094	$\"[1-145]T$	PTS_EIIA_TYPE_2

InterPro
IPR004715
Domain

Phosphotransferase system, IIA component fructose subfamily
TIGR00848	$\"[1-129]T$	fruA: PTS system, fructose subfamily, IIA c

noIPR
unintegrated

unintegrated
PTHR22931	$\"[46-123]T$	PHOSPHOENOLPYRUVATE DIKINASE-RELATED
PTHR22931:SF10	$\"[46-123]T$	PHOSPHOENOLPYRUVATE-PROTEIN PHOSPHOTRANSFERASE

","BeTs to 6 clades of COG1762COG name: Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)Functional Class:� G,TThe phylogenetic pattern of COG1762 is --------EB-H--gPOLIN-Number of proteins in this genome belonging to this COG is 4","***** IPB002178 (phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) with a combined E-value of 1.9e-07. IPB002178 46-63","Residues 29-129 are 31% similar to a (COMPONENT IIABC SYSTEM PHOSPHOTRANSFERASE) protein domain (PD346891) which is seen in PTFA_MYCPN.Residues 37-116 are 30% similar to a (IIA PTS DNA-BINDING COMPLETE) protein domain (PD171762) which is seen in O32346_CAUCR.Residues 1-132 are 33% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIA ENZYME COMPLETE) protein domain (PD001689) which is seen in P71012_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:01:23 2002","Fri Dec 14 14:26:07 2001","Fri Dec 14 14:28:57 2001","Fri Dec 14 14:26:07 2001","Fri Dec 14 14:26:07 2001","Fri Dec 14 14:26:07 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0103 is paralogously related (blast p-value < 1e-3) to SMu0795, and SMu1083, PTS-related components.","Fri Dec 14 14:29:24 2001","","No significant hits to the NCBI PDB database.","SMU.115","","Residues 1 to 145 (E-value = 7.6e-20) place SMu0103 in the PTS_EIIA_2 family which is described as Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PF00359)","Fri Dec 14 14:26:07 2001","24378635","","","","","","1","","","SMU.115","" "SMu0104","115645","116634","990","ATGATTTTATCACAGCAAAAATATAATTATTTAGCAAAAGTCAGTGATTCAAATGGCGTTATTTCAGCTCTAGCCTTTGATCAACGCGGTGCCTTGAAATGTTTGATGGCACAATATCAGATGAAGGAGCCGACAGTTGCTCAAATGGAAGAACTGAAAGTGCTGGTGTCAGAAGAATTAACACCCTATGCTTCATCTATTCTCCTTGATCCTGAATATGGCTTGCCAGCTGCACAAGCGCGTGATAGGGAAGCAGGACTCTTGTTAGCTTACGAAAAAACGGGTTATGATGCGAACACAACCAGTCGTTTGCCAGATTGTTTAGTGGACTGGTCTATTAAGCGGCTGAAAGAAGCGGGTGCTGACGCTGTTAAATTCTTGCTCTATTATGATGTTGATGGAGATCCACAAGTTAATGTGCAAAAACAAGCTTACATTGAGCGTATTGGCTCTGAATGTCAAGCTGAAGATATTCCGTTTTTCCTTGAAATTCTCACTTACGACGAAACAATCTCAAATAATTCAAGTGTTGAATTTGCTAAAGTAAAGGTGCATAAGGTCAATGATGCTATGAAAGTTTTTTCAGCTGAGCGTTTTGGTATAGATGTTCTTAAGGTTGAAGTGCCTGTTAATATGGTATATGTTGAAGGGTTTGCTGAAGGCGAAGTAGTGTATAGTAAAGAAGAAGCAGCACAAGCCTTTCGTGAACAGGAGGCCTCAACAGATTTACCTTACATTTACTTAAGCGCTGGTGTTAGTGCAGAGCTTTTTCAAGAAACGCTTGTTTTTGCGCATAAGGCAGGTGCTAAGTTTAATGGTGTCCTTTGTGGACGTGCCACATGGGCAGGGTCTGTTCAGGTTTATATGGAAGAAGGAAAGGAAGCAGCACGTCAATGGTTGCGTACGAGTGGCTTGCAAAATATCAATGAACTTAACAAGGTTTTAAAAACAACTGCATCACCTTGGACAGAAAAAGTGTCAGTTGGTTGA","4.60","-13.67","36545","MILSQQKYNYLAKVSDSNGVISALAFDQRGALKCLMAQYQMKEPTVAQMEELKVLVSEELTPYASSILLDPEYGLPAAQARDREAGLLLAYEKTGYDANTTSRLPDCLVDWSIKRLKEAGADAVKFLLYYDVDGDPQVNVQKQAYIERIGSECQAEDIPFFLEILTYDETISNNSSVEFAKVKVHKVNDAMKVFSAERFGIDVLKVEVPVNMVYVEGFAEGEVVYSKEEAAQAFREQEASTDLPYIYLSAGVSAELFQETLVFAHKAGAKFNGVLCGRATWAGSVQVYMEEGKEAARQWLRTSGLQNINELNKVLKTTASPWTEKVSVG","116631","For other 'lac' genes see SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC); SMu1354 (lacX);SMu1355 (lacG); SMu1356 (lacE); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). ","tagatose 1,6-aldolase","Cytoplasm","This sequence has been previously published in GenBank as gi|125926, gi|322120, gi|153676. Residues 1-325 are 73% similar to these sequences. Residues 3-326 are 74% similar to the enzyme from S.pyogenes (gi|15675728).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1928 (1e-128).","

InterPro
IPR002915
Family

Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase
PF01791	$\"[21-283]T$	DeoC

InterPro
IPR005927
Family

Tagatose 1,6-diphosphate aldolase, Gram positive
TIGR01232	$\"[2-326]T$	lacD: tagatose 1,6-diphosphate aldolase

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[4-327]T$	no description

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-286 are 74% similar to a (ALDOLASE LYASE D-TAGATOSE-16-BISPHOSPHATE) protein domain (PD401329) which is seen in LACD_LACLA.Residues 288-325 are 68% similar to a (ALDOLASE LYASE D-TAGATOSE-16-BISPHOSPHATE) protein domain (PD024298) which is seen in LACD_LACLA.Residues 11-285 are 76% similar to a (ALDOLASE TAGATOSE-BISPHOSPHATE LYASE) protein domain (PD017729) which is seen in LACD_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:02:24 2002","Fri Dec 14 14:30:05 2001","Fri Dec 14 14:35:21 2001","Fri Dec 14 14:30:05 2001","","Fri Dec 14 14:30:05 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0104 is paralogously related (blast p-value < 1e-3) to SMu1358, a predicted tagatose-1,6-bisphosphate aldolase.","Fri Dec 14 14:36:28 2001","","No significant hits to the NCBI PDB database.","SMU.116","","Residues 6 to 325 (E-value = 2.7e-217) place SMu0104 in the LacD family which is described as Tagatose 1,6-diphosphate aldolase, (LacD) (PF04274)","Fri Dec 14 14:30:05 2001","24378636","","Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 93015655","","Thu Apr 4 10:40:59 2002","","1","","","SMU.116","" "SMu0105","118090","116735","1356","ATGAACTCAGTGATAAAAAATACCGCAGCTTCGCTAGGGGAAGCTTTAGCAGAAGGTGCTGTTATCGTTCCAAACATCATCTTTGCAGGACTTTTATATCAGCATTATGGGCAGTATCACTTTTTACTTCCTTTCGTTTTATTATACTCATTTGAAAAAGCAGGGGTCTTCGCTATACAAGGATTTGGCGAATTGAAAAATCCATACAAAGTTTTAAGATATAGCCTCCTGCTAGCTATTTTGGGAACTTGCCTTTGTTTATTTGGTGATTTTTCCTTTTTATTTTGGGAATTGGGTGCTGTTTTAATAGGGCTTGGTTTAGCCAATTATAAGGCACTTTTCAAGACAATCAAAAGTATGTTGAAAGAAAAAAATGAATGGCCCTATAAAAGAACAATAATAATGGCTTATCTTATTTTAGGAATCATCATTTCATTATTTTTATATTTTCGCCATACTTCCATAACCTTAGTTTTTACTTTCTTTTTGCTTATGTTACTCACTTCATATGCCTTTATCTGTCAATTGGAACAAGAAGCCAACCTTAGCCAGCAAGTTCCTTTTGAAAGAAAACGAAATGCTTATCTTCATTTTTTTCCAGCCATTAGCATGCTGCTATTTTCTTTTTTTACAAGATTACTTAAACAGACAGCTAATACAAACTATGCTTTGTATATTGGACTTTCTCTTTGCTTATTTATCATTATCGGTCTGCTTTTTAAACCCTTGCATTTTTCTCAACAAGCTTTATTGACTTTATGGTTCGGTGCTGCCAGAAATTTTTTAGTCATCTATAGCCTTATTTACTTTATAGCTATTGATAAACTGTATATGGTTGGACTTTCTTATACAATGCTCGTTCTAGGCTTAATGCTCTCTATGACAAGCAGAAAGAAACTTCAACAGATCATAAATCCATCTTATTTTACTATCGTTTGTTTACTGGCTAGTACAGCAAGTTTTTTATTACTTTTATGGCCCTCAGCTTATCTCCTAGGTATTCTGCTAAGCTCTGCTTTTATTGCTAGCGGCAATCATGTCATTCTCCAAGAATTTACAAGAGATGAGACGTTACCGCTTTTAGAAAGAAGAATTACTCACTCCAAATTTTACGGACTGGGTGCTATTATTCAACAATTTATTTTGTTATTGACTCTGATCGGAGTTTCTTGGAAGCAACATCAATACTCAGCCTTAAGCGCCTATGCATTCTCTAGTAATGTTAAGAATTTAGAAACTATTTTCTTTTATACAAGAGTCACTTGTCTTGTTTTCATTGGAATCGCCGGGATTGGGTTGATAAAACGAAGTTTATCCTATATAGCCAACAACAATCAAAAAAGAACTAATAGCTGA","10.40","19.63","51234","MNSVIKNTAASLGEALAEGAVIVPNIIFAGLLYQHYGQYHFLLPFVLLYSFEKAGVFAIQGFGELKNPYKVLRYSLLLAILGTCLCLFGDFSFLFWELGAVLIGLGLANYKALFKTIKSMLKEKNEWPYKRTIIMAYLILGIIISLFLYFRHTSITLVFTFFLLMLLTSYAFICQLEQEANLSQQVPFERKRNAYLHFFPAISMLLFSFFTRLLKQTANTNYALYIGLSLCLFIIIGLLFKPLHFSQQALLTLWFGAARNFLVIYSLIYFIAIDKLYMVGLSYTMLVLGLMLSMTSRKKLQQIINPSYFTIVCLLASTASFLLLLWPSAYLLGILLSSAFIASGNHVILQEFTRDETLPLLERRITHSKFYGLGAIIQQFILLLTLIGVSWKQHQYSALSAYAFSSNVKNLETIFFYTRVTCLVFIGIAGIGLIKRSLSYIANNNQKRTNS","116738","","conserved hypothetical protein","Membrane, Cytoplasm","Single significant match in gapped BLAST to gi|15673508 in Lactococcus. Residues 42-362 are 22% similar to residues 40-357 of gi|15673508.SMu0105 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[204-354]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[15-33]?$ $\"[74-108]?$ $\"[129-149]?$ $\"[155-173]?$ $\"[194-212]?$ $\"[222-240]?$ $\"[250-272]?$ $\"[276-294]?$ $\"[303-323]?$ $\"[329-349]?$ $\"[370-390]?$ $\"[414-434]?$	transmembrane_regions

InterPro
IPR000801
Family

Putative esterase
PF00756	$\"[13-269]T$	Esterase

InterPro
IPR014186
Family

S-formylglutathione hydrolase
TIGR02821	$\"[2-274]T$	fghA_ester_D

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[4-269]T$	G3DSA:3.40.50.1820
PTHR10061	$\"[1-276]T$	PTHR10061
SSF53474	$\"[6-279]T$	SSF53474

","BeTs to 3 clades of COG0627COG name: Predicted esteraseFunctional Class:� RThe phylogenetic pattern of COG0627 is ----y--cE--h---------Number of proteins in this genome belonging to this COG is 2","***** IPB000801 (Putative esterase) with a combined E-value of 1.1e-42. IPB000801A 77-88 IPB000801B 100-126 IPB000801C 143-152 IPB000801D 171-200","Residues 213-276 are 40% similar to a (SMC3-MRPL8 ESTERASE HYDROLASE) protein domain (PD113922) which is seen in YJG8_YEAST.Residues 40-198 are 63% similar to a (ESTERASE HYDROLASE PROTEOME COMPLETE) protein domain (PD007616) which is seen in YAIM_HAEIN.Residues 1-36 are 58% similar to a (PROTEOME FOLE-CIRA CG4390 COMPLETE) protein domain (PD405326) which is seen in Q9HY02_PSEAE.Residues 199-271 are 46% similar to a (ESTERASE HYDROLASE PROTEOME COMPLETE) protein domain (PD007617) which is seen in YAIM_ECOLI.Residues 40-198 are 61% similar to a (ESTERASE PROTEOME COMPLETE LIPASE) protein domain (PD123655) which is seen in Q9JZ43_NEIMB.Residues 15-189 are 29% similar to a (GLYCOSIDASE XYLAN DEGRADATION HYDROLASE) protein domain (PD017485) which is seen in Q59790_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:03:13 2002","Fri Dec 14 15:01:36 2001","Fri Dec 14 15:04:56 2001","Fri Dec 14 15:01:36 2001","Fri Dec 14 15:01:36 2001","Fri Dec 14 15:01:36 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0106 is paralogously related (blast p-value < 1e-3) to SMu1314, a predicted tributyrin esterase.","Fri Dec 14 15:05:59 2001","","No significant hits to the NCBI PDB database.","SMU.118c","","Residues 13 to 269 (E-value = 6.6e-95) place SMu0106 in the Esterase family which is described as Putative esterase (PF00756)","Fri Dec 14 15:01:36 2001","24378638","","","","","","1","","","SMU.118c","" "SMu0107","120676","119558","1119","ATGAATACTATCAAAACACGAGCAGCAGTTGCTTGGGCACCCAATGAACCCTTGAAAATTGAAGAGTTGGACCTGATGATGCCACAAAAGGGAGAGGTTATGGTGCATATTACAGCGACAGGAGTCTGTCATACCGATGCCTATACCCTATCAGGAAAAGATGCAGAAGGGGTTTTCCCTTGCGTTTTGGGACATGAAGGTGCTGGTATCGTTGAAGCAGTGGGCGAAGGCGTAACAGAGTTTCAGGTCGGTGATCATGTGATCCCGCTTTATACAGCCGAATGCGGTAAATGTGAGTTCTGCCTTTCAGGAAAGACCAACCTATGCTCAGCCGTTCGTGAGACACAAGGCCGCGGTGTCATGCCTGACGGGACAGTTCGTTTCTTTAAGGATGGTCAACCTATTTATCATTATATGGGAACCTCAACATTTGCAGAACATACTGTTGTTTCAGAGTATTCTTTGGTTAAAATACAGGACAATGCGCCGCTTGAAGAAGTCTGTTTGCTGGGCTGCGGTGTAACAACTGGCATGGGGGCTGTTTTGAATACAGCTAAAGTCGAAGAGGGAGCAACTGTGGCCATTTTTGGTCTAGGCGGTATCGGACTAGCTGCTATTATTGGTGCTCGTATGGCTAAAGCCTCTCGAATCATTGCTATTGATATTAATCCCGATAAGTTTGACAAGGCTAGAAAATTGGGAGCTACCGATTTAGTCAATCCCAATAATCATGCTAAACCAATTCAGGAAGTCATTATTGACATAACCAACGGCGGTGTTGATTATTCCTTTGAATGTATCGGAAACGTAGAAGTCATGCGGGCTGCCTTGGAATGCTGCCACAAGGGTTGGGGAGAGAGTACTATCATCGGTGTAGCACCAGCTGGTGCTGAAATTCATACTCGTCCATTTCAATTGGTTACAGGTCGTGTCTGGCGTGGTTCAGCTTTCGGTGGTGTTAAAGGCAAAACACAGCTGCCGGGAATTGTTGGACAATATATGGCTGGCGAGTTTGCATTGAGTGATTTTATTACCCATACCATGCCTCTAGAGCAGATTAACGATGCCTTTGACTTGATGCATGAAGGCAAATCTATTCGCACAGTCATTCATTACTGA","5.50","-10.61","39717","MNTIKTRAAVAWAPNEPLKIEELDLMMPQKGEVMVHITATGVCHTDAYTLSGKDAEGVFPCVLGHEGAGIVEAVGEGVTEFQVGDHVIPLYTAECGKCEFCLSGKTNLCSAVRETQGRGVMPDGTVRFFKDGQPIYHYMGTSTFAEHTVVSEYSLVKIQDNAPLEEVCLLGCGVTTGMGAVLNTAKVEEGATVAIFGLGGIGLAAIIGARMAKASRIIAIDINPDKFDKARKLGATDLVNPNNHAKPIQEVIIDITNGGVDYSFECIGNVEVMRAALECCHKGWGESTIIGVAPAGAEIHTRPFQLVTGRVWRGSAFGGVKGKTQLPGIVGQYMAGEFALSDFITHTMPLEQINDAFDLMHEGKSIRTVIHY","119561","For other 'adh' genes see SMu0113 (adhA);SMu0114 (adhB); SMu0115 (adhC); SMu0116 (adhD); SMu0131 (adhE); SMu1698 (adhB) and SMu1299 (adhD).","alcohol dehydrogenase class III","Cytoplasm","Similarities in gapped BLAST to Adh proteins. Residues 4-372 are 69% similar to gi16121775 from Y.pestis and 68% similar to the enzyme from P.aeruginosa (gi15598825).This sequence is similar to Spy0044.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0054 (2e-12).","

InterPro
IPR002085
Family

Alcohol dehydrogenase superfamily, zinc-containing
PTHR11695	$\"[4-223]T$	ADH_Sf_Zn

InterPro
IPR002328
Domain

Alcohol dehydrogenase, zinc-containing
PS00059	$\"[64-78]T$	ADH_ZINC

InterPro
IPR011032
Domain

GroES-like
SSF50129	$\"[4-188]T$ $\"[320-372]T$	GroES_like

InterPro
IPR013149
Domain

Alcohol dehydrogenase, zinc-binding
PF00107	$\"[189-331]T$	ADH_zinc_N

InterPro
IPR013154
Domain

Alcohol dehydrogenase GroES-like
PF08240	$\"[30-158]T$	ADH_N

InterPro
IPR014183
Family

Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
TIGR02818	$\"[5-372]T$	adh_III_F_hyde

noIPR
unintegrated

unintegrated
G3DSA:3.90.180.10	$\"[4-372]T$	G3DSA:3.90.180.10
PTHR11695:SF4	$\"[4-223]T$	PTHR11695:SF4
SSF51735	$\"[173-322]T$	SSF51735

","BeTs to 5 clades of COG1062COG name: Alcohol dehydrogenase class III and related dehydrogenasesFunctional Class: C,RThe phylogenetic pattern of COG1062 is ----y-vcE-Rh---------Number of proteins in this genome belonging to this COG is 1","***** IPB002328 (Zinc-containing alcohol dehydrogenase) with a combined E-value of 1e-67. IPB002328A 17-48 IPB002328B 60-85 IPB002328C 95-109 IPB002328D 155-202***** IPB002364 (Quinone oxidoreductase/zeta-crystallin) with a combined E-value of 9.9e-15. IPB002364 60-87","Residues 334-364 are 74% similar to a (DEHYDROGENASE ALCOHOL OXIDOREDUCTASE ZINC NAD FAMILY) protein domain (PD000463) which is seen in Q59399_ECOLI.Residues 330-370 are 53% similar to a (DEHYDROGENASE OXIDOREDUCTASE ZINC) protein domain (PD331433) which is seen in FAH1_SCHPO.Residues 213-269 are 50% similar to a (DEHYDROGENASE OXIDOREDUCTASE ZINC) protein domain (PD400275) which is seen in FAH2_SCHPO.Residues 7-63 are 64% similar to a (OXIDOREDUCTASE DEHYDROGENASE ZINC ALCOHOL NAD COMPLETE) protein domain (PD225307) which is seen in ADH3_SYNY3.Residues 144-177 are 73% similar to a (DEHYDROGENASE ALCOHOL ZINC OXIDOREDUCTASE NAD MULTIGENE) protein domain (PD414038) which is seen in Q9RDU5_PSESP.Residues 272-307 are 72% similar to a (DEHYDROGENASE GSH-DEPENDENT FORMALDEHYDE) protein domain (PD372551) which is seen in Q9F5P1_RHIME.Residues 210-292 are 55% similar to a (DEHYDROGENASE ALCOHOL OXIDOREDUCTASE ZINC) protein domain (PD346209) which is seen in Q9FZ01_VITVI.Residues 4-63 are 68% similar to a (LYASE DEHYDROGENASE ALCOHOL) protein domain (PD355263) which is seen in Q59399_ECOLI.Residues 2-63 are 69% similar to a (DEHYDROGENASE ALCOHOL III ZINC) protein domain (PD335676) which is seen in Q9JRB0_NEIMB.Residues 144-192 are 69% similar to a (DEHYDROGENASE ALCOHOL OXIDOREDUCTASE ZINC NAD) protein domain (PD085468) which is seen in ADHX_DROME.Residues 330-370 are 56% similar to a (ALCOHOL DEHYDROGENASE OXIDOREDUCTASE ZINC) protein domain (PD249577) which is seen in ADH1_TRIRP.Residues 119-193 are 41% similar to a (PROTEOME COMPLETE ALCOHOL DEHYDROGENASE) protein domain (PD272789) which is seen in O07407_MYCTU.Residues 272-372 are 31% similar to a (ALCOHOL DEHYDROGENASE OXIDOREDUCTASE) protein domain (PD278856) which is seen in Q43169_SOLTU.Residues 210-307 are 83% similar to a (OXIDOREDUCTASE DEHYDROGENASE ZINC ALCOHOL NAD COMPLETE) protein domain (PD000104) which is seen in Q9RDU5_PSESP.Residues 84-143 are 81% similar to a (DEHYDROGENASE ALCOHOL OXIDOREDUCTASE ZINC NAD FAMILY) protein domain (PD000160) which is seen in ADH3_PASPI.Residues 144-193 are 50% similar to a (PHOSPHOPANTETHEINE TRANSFERASE SYNTHASE OXIDOREDUCTASE) protein domain (PD189697) which is seen in Q9S247_STRCO.Residues 13-370 are 23% similar to a (ALCOHOL DEHYDROGENASE OXIDOREDUCTASE ZINC) protein domain (PD201070) which is seen in O87871_THAAR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 8 10:53:42 2006","Fri Dec 14 15:06:58 2001","Wed Feb 8 10:53:42 2006","Thu Apr 4 14:16:06 2002","Fri Dec 14 15:06:58 2001","Fri Dec 14 15:06:58 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0107 is paralogously related (blast p-value < 1e-3) to SMu1698, a predicted alcohol dehydrogenase, and to SMu1005, a predicted oxidoreductase.","Fri Dec 14 15:11:24 2001","Wed Feb 8 10:53:42 2006","pdb1TEHA Chain A, Structure Of Human Liver Chichi Alcohol Deh... 429 3e-121pdb1CDOA Chain A, Alcohol Dehydrogenase (E.C.1.1.1.1) (Ee Iso... 362 3e-101pdb1HDYA Chain A, Alcohol Dehydrogenase (E.C.1.1.1.1) (Beta-2... 337 1e-093","SMU.119c","","Residues 13 to 372 (E-value = 1.2e-137) place SMu0107 in the ADH_zinc_N family which is described as Zinc-binding dehydrogenase (PF00107)","Fri Dec 14 15:06:58 2001","","","","","","","1","","","SMU.119c","" "SMu0108","121103","121291","189","ATGGCTAAAGTATGTTATTTTACAGGACGTAAAACTGTATCAGCAAATAACCGTTCACATGCGATGAACAAAACAAAACGTGTTGCAAAACCAAATCTTCAAAAGGTAACTGTTCTTATTGACGGTAAACCTAAAAAAGTTTGGGCTTCAGCTCGTGCTCTTAAGTCTGGTAAAGTTGAGCGTGTATAA","11.90","14.17","6881","MAKVCYFTGRKTVSANNRSHAMNKTKRVAKPNLQKVTVLIDGKPKKVWASARALKSGKVERV","121288","For other 'rpm' genes see SMu0638 (rpmI);SMu0773 (rpmA);SMu0306 (rpmH); SMu1185 (rpmE) and SMu1464 (rpmG).For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu1840 (rl3); SMu1839 (rl4);SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9). ","50S ribosomal protein L28","Periplasm, Extracellular","Several matches in gapped BLAST to 50S ribosomal protein L28 sequences. Residues 1-62 are 93% similar to the protein from S.pneumoniae (gi|15900358) and 88% similar to the protein from S.pyogenes (gi|15675704).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0129 (3e-29).","

InterPro
IPR001383
Family

Ribosomal protein L28
PF00830	$\"[3-61]T$	Ribosomal_L28
TIGR00009	$\"[1-56]T$	L28

","BeTs to 11 clades of COG0227COG name: Ribosomal protein L28Functional Class: JThe phylogenetic pattern of COG0227 is ----yqvcebRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001383 (Ribosomal protein L28) with a combined E-value of 1.3e-21. IPB001383 1-39","Residues 5-62 are 87% similar to a (RIBOSOMAL 50S L28-1) protein domain (PD383919) which is seen in RL28_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:07:04 2002","Fri Dec 14 15:15:10 2001","Fri Dec 14 15:17:40 2001","Thu Apr 4 13:33:24 2002","Fri Dec 14 15:15:10 2001","Fri Dec 14 15:15:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0108 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 15:17:40 2001","","No significant hits to the NCBI PDB database.","SMU.120","","Residues 3 to 61 (E-value = 1.1e-22) place SMu0108 in the Ribosomal_L28 family which is described as Ribosomal L28 family (PF00830)","Fri Dec 14 15:15:10 2001","24378640","","","Arnold,R.J. and Reilly,J.P.Observation of Escherichia coli ribosomal proteins and theirposttranslational modifications by mass spectrometryAnal. Biochem. 269 (1), 105-112 (1999)PubMed: 10094780Kruft,V., Kapp,U. and Wittmann-Liebold,B.Characterization and primary structure of proteins L28, L33 and L34 from Bacillus stearothermophilus ribosomesBiochimie 73 (7-8), 855-860 (1991)PubMed: 1742360","","Thu Apr 4 13:33:24 2002","1","","","SMU.120","882" "SMu0109","122672","121344","1329","ATGACGGACTTAACCAAGGGAAGTGAATTAAAAACAATCTTATATTTTTCCATTCCTATTCTTTTAGGAAATTTATGTGAACAATTGTATAATGTGACGGATACTGCAATTGTTGGAAATCTTGTGGGTACAAAAGGACTGGCTGCTGTCGGAGCCAGTACCCAAGTCGTTACGCTGACAGTTGCTCTCTCAACAGGAGTTTCCATTGGAGCCAGCGTGTTAATATCTCAACTTTATGGAGCAAAGCATTTCCAAAAAATGAAAAGCGTTCTGGATACCAACTTGATGTTCACAAGTATACTGGCCTTTGTGTTAACCCTTTTCGGTATCTATTATGCAAACCCTTTTTTAAAGCAGTTAAATGTTCCACAACCTTTATTACCTGAGGCCGACGGCTATTTAAAAATTATTTTGTTGGGCTTAGTCCCACTTTTTGCTTACAATACTTTAGCAAATTGTTTAAGAGGAATAGGAGATTCTAAAACACCAACTTTTATTTTAATCAGTTCGATCTGTCTGAATGCCTCTTTGGACATTATTTTCATCGCCGTTTTTCACCAAGGCAGTGCTGGAGCTGCTATGGCCACAGTGTTCGCTCAACTTTTTTCTTTTCTTATCTGTTTAATTTATATGAAAAAGAAATATCCCCAATTATCGCCTGACTTGTTCCATTTAAAATGGCAGCTTAAAACATTACAAAAATCTTTAGCCATTGGTCTTCCCGCCATGATGCAACAGGTTTTCATTAGTTTTGGTTTTCTTGTCATTCAATTTCTTGTCAACAGCTTTGGAACAAGTGCTATTGCTGCTTACACAGCCGCCTCTAAGGTTGACTCTTTTGCAGAAATGCCCGCTGTTAATCTTGGACAAGCCTTAATGAATTTCACCGCTCAAAATGAAGGTGCTGGAAAAGGAAAGCGGATTACAAAGGGAGGCAATCATACCTTGCTTTTTTCAATAGGCTTATCGGTCAGCATATCTGTTATCATTTATATTTTTGCTCCAGTCCTCATTTCTATTTTTAACCGTGATGCAACCGTTGTGCAGATCGGTCAGCAATACCTACATATCGTATCAGTCTTTTATCCCATTTTCGGAGCTATGCAAGTTCTTAATGGCATTCTGTTAGGTTACGGAAAGTCACTCCTTCCTTTAATTGCTTCTATAACAACTTTCTGTATTCTTCAAGTGCCTTTAGCTGTTTTACTCTCGCACACTTCATTAGGCTTCAATGGTATTTGGATGGCTGCTCCTTTTGGCTGGACAGCAGGATTTCTGATGCGCTTAATCTATTTCAGATATCTTTTAAAAAGAAAAAATCAAGGTTAA","10.30","15.19","47929","MTDLTKGSELKTILYFSIPILLGNLCEQLYNVTDTAIVGNLVGTKGLAAVGASTQVVTLTVALSTGVSIGASVLISQLYGAKHFQKMKSVLDTNLMFTSILAFVLTLFGIYYANPFLKQLNVPQPLLPEADGYLKIILLGLVPLFAYNTLANCLRGIGDSKTPTFILISSICLNASLDIIFIAVFHQGSAGAAMATVFAQLFSFLICLIYMKKKYPQLSPDLFHLKWQLKTLQKSLAIGLPAMMQQVFISFGFLVIQFLVNSFGTSAIAAYTAASKVDSFAEMPAVNLGQALMNFTAQNEGAGKGKRITKGGNHTLLFSIGLSVSISVIIYIFAPVLISIFNRDATVVQIGQQYLHIVSVFYPIFGAMQVLNGILLGYGKSLLPLIASITTFCILQVPLAVLLSHTSLGFNGIWMAAPFGWTAGFLMRLIYFRYLLKRKNQG","121347","For other 'din' genes see SMu0364 (dinP) and SMu1200 (dinG). ","MATE efflux family , DinF","Membrane, Cytoplasm","Similarities to conserved hypothetical proteins and to MATE efflux family proteins such as DinF. Residues 3-423 are 32 % similar to gi15901763 of S.pneumoniae and 32% similar to an unknown from B.halodurans (gi15613449).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0056 (4e-23).","

InterPro
IPR002528
Family

Multi antimicrobial extrusion protein MatE
PTHR11206	$\"[33-441]T$	MatE
PF01554	$\"[19-180]T$ $\"[241-402]T$	MatE
TIGR00797	$\"[19-414]T$	matE

InterPro
IPR015522
Family

Na+ driven multidrug efflux pump
PTHR11206:SF6	$\"[33-441]T$	MATE_trans_like

","BeTs to 15 clades of COG0534COG name: Probable cation efflux pump (multidrug resistance protein)Functional Class: RThe phylogenetic pattern of COG0534 is amtKYqVCEBrhUJgpOl---Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 19-81 are 47% similar to a (COMPLETE PROTEOME TRANSMEMBRANE EFFLUX) protein domain (PD001078) which is seen in O33729_STRPN.Residues 16-107 are 29% similar to a (PROTEOME COMPLETE MEMBRANE INTEGRAL) protein domain (PD414743) which is seen in Q9KU73_VIBCH.Residues 241-308 are 39% similar to a (COMPLETE PROTEOME MEMBRANE INTEGRAL) protein domain (PD188136) which is seen in Q9KEG6_BACHD.Residues 337-439 are 26% similar to a (PROTEOME COMPLETE YOEA) protein domain (PD395614) which is seen in O34474_BACSU.Residues 3-128 are 26% similar to a (ILVA 3'REGION TRANSMEMBRANE) protein domain (PD397084) which is seen in YPNP_BACSU.Residues 123-210 are 42% similar to a (PROTEOME COMPLETE TRANSMEMBRANE VIRULENCE) protein domain (PD001019) which is seen in Q9KEG6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:17:46 2007","Thu Feb 8 14:34:31 2007","Thu Feb 8 14:34:31 2007","Thu Apr 4 13:28:21 2002","","Fri Mar 16 11:17:46 2007","yes","Fri Feb 20 15:41:32 MST 1998","SMu0109 is paralogously related (blast p-value < 1e-3) to SMu0064, a predicted MATE efflux family protein.","Fri Dec 14 15:27:22 2001","","No significant hits to the NCBI PDB database.","SMU.121c","","Residues 19 to 180 (E-value = 1.1e-40) place SMu0109 in the MatE family which is described as MatE (PF01554)Residues 241 to 402 (E-value = 8.2e-33) place SMu0109 in the MatE family which is described as MatE (PF01554)","Thu Feb 8 14:34:31 2007","","","","Brown,M.H., Paulsen,I.T. and Skurray,R.A.The multidrug efflux protein NorM is a prototype of a new family of transportersMol. Microbiol. 31 (1), 394-395 (1999)PubMed: 9987140","","Thu Apr 4 13:28:21 2002","1","","","SMU.121c","" "SMu0110","122905","127302","4398","ATGTCGGAATTGTTTAAAAAATTGATGGATCAGATTGAGATGCCGCTTGAAATGAAGAATTCAAGGGTTTTTTCATCTGCTGATATTGTGGAAGTGAAGGTTTATCCTGAGAGTCGGATTTGGGATTTCCGTTTTTCTTTTGAGACCATCTTACCAATTGATTTTTATCAGGAGTTAAGAAGCAGATTAGTGACGAGTTTTGAAACAGCTGATATTAAGGCTGTTTTTGACATTGAAGTGGAGAATGCTGAATTTTCTAACGAGCTTTTGCAGGCTTATTATCAGGAGGCTTTTAAGCAGCCGACTTGCAATAGTGCTAGTTTTAAAAGCTCTTTTTCGCACTTAACTGTTTCCTATACTGATGGGAAAGTTCTTATTTCAGCGCCGCAATTTGTCAATAATGATCATTTTCGAAAGAATCATTTACCTAATCTTGAAAAGCAGTTTGAAGCGTTTGGGTTTGGGAAATTAAGTTTTGACATTGTATCTAATCAAAAAATGACAGAGGAAATAAAACATCATTTTGAATCCTCTCGTCAGCAGCAAATTCAAAAGGCTAGTCAAGAAACGCTAGAAATTCAAAAATCATTAGAAGCTTCAATACCGCCTGAAGAAATTCCTAAACCCGTATCCAATTTCAAAGAGCGAATCAAGGATCGGCAAGCAGCTTTTGAAAAGGCTGAGATTACGCCTATGGCTGAAATTGAAACTGAGGAAAACCGCATCACATTTGAAGGGCTTGTTTTTGATGTGGAACGCAAGACAACAAGAACCGGACGTCATATCATCAATTTTAAAATGACGGATTATACCTCAAGTTTTCCGATGCAAAAGTGGGCTAAGGATGATGAAGAATTAAAGAAATATGACATGATTTCTAAGGGTGCTTGGTTGCGCGTGCGTGGCAATATCGAGAATAATCCTTTTACAAAAGCCTTAACCATGAATGTCCAAAATGTCAAGACCATTGTTCATAAAGAGCGTAAGGACTTAATGCCCCAAGGGGAAAAACGTGTTGAATTTCACGCTCATACCAATATGTCAACCATGGATGCTTTGCCAACAGTTGAGCAATTAGTGGCCAAGGCGGCTCAGTTTGGTCATCCTGCGGTTGCTATTACGGATCATGGCAATGTTCAGAGTTTCCCTCATGGCTATCATGCAGGTAAAAAGAATGGCATTAAGGTTCTCTTTGGCTTGGAGGCTAATCTTGTTGAGGACCGTGTACCTATTGTCTACAATGAAGTTGATATGGATATGAATGAAGCGACCTATGTTGTTTTTGACGTGGAAACTACAGGACTTTCAGCCATCAATAATGATTTGATTCAGATTGCAGCTTCTAAGATGCATAAAGGAAATATTGTTGAGCAATTTGATGAGTTTATTGATCCCGGGCATCCGCTCAGTCAGTTTACAACCGATTTAACAGGGATCACAGATCAGCATGTGAAAGGGGCTAAGCCCATTTCACAAGTATTGCAGGAATTTCAGTCCTTTTGTCAAGATACAGTTTTAGTTGCCCATAACGCCACTTTTGACGTTGGCTTTATGAATGCCAATTATGAAAGGCATGACCTGCCAAAGATTACGCAGCCAGTCATTGATACCTTGGAATTTGCACGAAATCTTTATCCAGAATACAAGCGTCATGGTTTAGGTCCTTTGACTAAACGCTTTCAGGTATCGCTTGAGCACCACCACATGGCTAATTACGACGCTGAGGCAACTGGTCGTCTGCTCTTTATCTTTCTTAAAGAGGCGAAAGAAAAGCATGGGGTCAACAATCTTTTAGATCTTAATACTAAAATTGTTGATGATAATTCTTACAAGAAAGCTCGGGTAAAGCATGCAACCATTTATGTCCTGAATCAAAAAGGGTTGAAAAATTTATTTAAATTAGTCAGTCTATCCAATGTTACTTATTTTGCAGGTGTGGCTAGAATACCAAGAACGATTCTTGATCAGTATCGTGATGGCCTCTTACTGGGGACAGCCTGCTCTGATGGTGAAGTTTTTGATACGGTTCTCTCAAAAGGGGTTGAAGATGCTGTGGAGGTAGCCAAGTATTATGATTTTATTGAAGTCATGCCACCTGCTCTTTATGAACCTCTTCTTGCTCGTGAATTAATCAAAGATGAAGCAGGAATTCAGCAAATTATTAAAGATCTTATTGAAGTTGGTCGTCGTTTAGATAAGCCTGTCTTGGCAACTGGTGATGTCCATTATCTGGAACCGGAAGACGAAATTTATCGTGAAATCATTGTTAGAAGTCTGGGACAGGGAGCTATGATTAATCGTCCTATTGGGCGTGGTGAAAATGCTCAGCCAGCTCCTCTGCCCAAGGCTCATTTTAGAACAACCAATGAGATGTTGGATGAATTTGCTTTTTTAGGCGAAGATTTAGCCCGTGACATTGTCATTAAAAATCCAAATGAGATGGTTGAGCGTTTTGAAGATGTTGAAGTTGTTAAAACAGACCTCTATACGCCTTTTATTGAGAATTCTGAAGAAAAAGTCGCTGAGATGACTTATGAAAAGGCCTTTGAAATTTATGGCAATCCTCTTCCGGATATCATTGACTTGCGTATTGAAAAAGAGTTGACTTCCATTTTGGGGAATGGATTTGCGGTGATTTATCTGGCTTCACAGATGCTGGTAAATCGTTCTAATGAACGTGGTTATCTGGTTGGTTCTAGAGGTTCGGTTGGTTCTAGTTTTGTGGCAACCATGATTGGTATTACAGAAGTGAATCCTATGCCGCCACACTATATTTGTCCCAATCCAGACTGTAAACATTCTGAATTTATCACGGATGGTTCTGTGGGTTCAGGCTATGATTTGCCTGATAAAATCTGTTCGGAATGCGGCACTCCGTACAAGAAAGATGGTCAGGATATTCCTTTTGAGACCTTCCTTGGTTTTGACGGAGACAAAGTTCCTGATATTGACTTGAACTTTTCAGGTGATGATCAGCCGAGTGCTCACTTAGATGTGCGTGATATTTTTGGTGAAGAATACGCCTTTCGTGCAGGAACAGTTGGTACGGTTGCAGATAGAACGGCTTATGGCTTTGTCAAAGGCTACGAAAGAGATTATGGCAAGTTTTACCGCGATGCAGAAGTTGATAGGCTGGCGCAGGGTTCAGCCGGTGTCAAACGAACAACTGGACAGCACCCCGGTGGGATCGTTGTTATTCCAAACTATATGGATGTTTATGATTTTACACCTGTTCAGTATCCTGCGGATGATTTAACAGCCGAATGGCAAACAACCCACTTTAACTTCCATGATATTGATGAAAATGTTCTTAAACTTGATGTGCTTGGTCATGATGATCCCACCATGATTCGCAAGTTGCAGGATTTGTCTGGTATTGATCCAAAAACAATTCCTGCTGACGATCCAGAAGTTATGAAACTGTTTTCAGGAACAGAAGTCTTGGGAGTTACTGAGGAAGAGATTGGAACACCGACTGGAATGCTAGGAATTCCTGAATTTGGAACCAACTTTGTTCGTGGAATGGTGGATGAGACCCATCCAACGACATTTGCGGAGCTTTTACAATTATCAGGACTTTCACATGGTACAGATGTGTGGTTGGGCAATGCACAGGATCTCATCAAACAAGGCATTGCAACGCTGTCAACGGTTATTGGTTGTCGTGATGATATTATGGTTTATCTTATGCATGCTGGTTTAGAACCTAAGATGGCCTTTACTATTATGGAGCGTGTACGTAAAGGGGCTTGGCTGAAGATTTCGGAGGAAGAGCGAAACGGGTATATCTCAGCCATGCGTGAGAATAATGTGCCGGATTGGTATATTGAATCCTGCGGAAAAATTAAATACATGTTTCCTAAAGCCCATGCGGCGGCTTATGTCTTGATGGCTCTTCGTGTTGCTTATTTTAAGGTGCATCACCCAATTTATTATTACTGTGCTTATTTCTCTATTCGTGCCAAGGCTTTTGAATTAAAGACAATGAGTGCTGGTTTGGATGCTGTTAAGGCACGCATGGCTGATATTAGTCAAAAGAGAAAAATCAACCAAGCTTCAAATGTTGAGATTGATCTTTTTACAACCTTAGAAATTGTCAATGAAATGTTGGAGAGAGGTTTCAAATTTGGACAGCTGGACTTGTATCGCAGTGATGCCACTGAATTTATCATTGATGGCGATACATTGATACCTCCTTTTGTGGCTTTGGAAGGTTTGGGCGAAAATGTTGCCAAACAAATCGTAAAAGCACGTAATGAAGGAGAGTTTCTTTCTAAGACAGAACTGCGTAAACGCGGCGGTTTGTCATCAACTTTGGTTGAAAAGATGAGCGATATGGGAATTTTAGGCAGTATGCCTGAAGATAATCAATTGTCACTTTTTGATGATTTCTTTTAA","5.00","-54.86","165575","MSELFKKLMDQIEMPLEMKNSRVFSSADIVEVKVYPESRIWDFRFSFETILPIDFYQELRSRLVTSFETADIKAVFDIEVENAEFSNELLQAYYQEAFKQPTCNSASFKSSFSHLTVSYTDGKVLISAPQFVNNDHFRKNHLPNLEKQFEAFGFGKLSFDIVSNQKMTEEIKHHFESSRQQQIQKASQETLEIQKSLEASIPPEEIPKPVSNFKERIKDRQAAFEKAEITPMAEIETEENRITFEGLVFDVERKTTRTGRHIINFKMTDYTSSFPMQKWAKDDEELKKYDMISKGAWLRVRGNIENNPFTKALTMNVQNVKTIVHKERKDLMPQGEKRVEFHAHTNMSTMDALPTVEQLVAKAAQFGHPAVAITDHGNVQSFPHGYHAGKKNGIKVLFGLEANLVEDRVPIVYNEVDMDMNEATYVVFDVETTGLSAINNDLIQIAASKMHKGNIVEQFDEFIDPGHPLSQFTTDLTGITDQHVKGAKPISQVLQEFQSFCQDTVLVAHNATFDVGFMNANYERHDLPKITQPVIDTLEFARNLYPEYKRHGLGPLTKRFQVSLEHHHMANYDAEATGRLLFIFLKEAKEKHGVNNLLDLNTKIVDDNSYKKARVKHATIYVLNQKGLKNLFKLVSLSNVTYFAGVARIPRTILDQYRDGLLLGTACSDGEVFDTVLSKGVEDAVEVAKYYDFIEVMPPALYEPLLARELIKDEAGIQQIIKDLIEVGRRLDKPVLATGDVHYLEPEDEIYREIIVRSLGQGAMINRPIGRGENAQPAPLPKAHFRTTNEMLDEFAFLGEDLARDIVIKNPNEMVERFEDVEVVKTDLYTPFIENSEEKVAEMTYEKAFEIYGNPLPDIIDLRIEKELTSILGNGFAVIYLASQMLVNRSNERGYLVGSRGSVGSSFVATMIGITEVNPMPPHYICPNPDCKHSEFITDGSVGSGYDLPDKICSECGTPYKKDGQDIPFETFLGFDGDKVPDIDLNFSGDDQPSAHLDVRDIFGEEYAFRAGTVGTVADRTAYGFVKGYERDYGKFYRDAEVDRLAQGSAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDLTAEWQTTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPKTIPADDPEVMKLFSGTEVLGVTEEEIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQDLIKQGIATLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGAWLKISEEERNGYISAMRENNVPDWYIESCGKIKYMFPKAHAAAYVLMALRVAYFKVHHPIYYYCAYFSIRAKAFELKTMSAGLDAVKARMADISQKRKINQASNVEIDLFTTLEIVNEMLERGFKFGQLDLYRSDATEFIIDGDTLIPPFVALEGLGENVAKQIVKARNEGEFLSKTELRKRGGLSSTLVEKMSDMGILGSMPEDNQLSLFDDFF","127299","For other 'pol' genes see SMu0268 (polA).For DNA polymerase III, beta subunit see SMu0002. For DNA polymerase III subunits gamma / tau see SMu1437. For DNA polymerase III, delta prime subunit see SMu1514. ","DNA polymerase III, alpha subunit","Cytoplasm","Several similarities in gapped BLAST to DNA polymerase III, alpha subunit sequences. Residues 1-1465 are 81% similar to DPO3_STRPY (gi14194673) and 80% similar to gi9789541.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1911 (0.0).","

InterPro
IPR003141
Domain

Polymerase and histidinol phosphatase, N-terminal
SM00481	$\"[339-406]T$	POLIIIAc

InterPro
IPR004013
Domain

PHP, C-terminal
PF02811	$\"[339-745]T$	PHP

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[242-323]T$	tRNA_anti

InterPro
IPR006054
Domain

DNA polymerase III, epsilon subunit
TIGR00573	$\"[417-642]T$	dnaq

InterPro
IPR006055
Domain

Exonuclease
SM00479	$\"[424-590]T$	EXOIII

InterPro
IPR006308
Family

DNA polymerase III, alpha subunit, Gram-positive type
TIGR01405	$\"[233-1461]T$	polC_Gram_pos

InterPro
IPR011708
Domain

Bacterial DNA polymerase III, alpha subunit
PF07733	$\"[783-1270]T$	DNA_pol3_alpha

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[424-586]T$	RNaseH_fold

InterPro
IPR013520
Domain

Exonuclease, RNase T and DNA polymerase III
PF00929	$\"[425-581]T$	Exonuc_X-T

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.10	$\"[418-592]T$	G3DSA:3.30.420.10
PTHR12801	$\"[459-509]T$	PTHR12801
SSF50249	$\"[236-325]T$	Nucleic_acid_OB
SSF89550	$\"[337-798]T$	SSF89550

","BeTs to 3 clades of COG2176COG name: DNA polymerase III alpha subunit, the Gram-positive typeFunctional Class: LThe phylogenetic pattern of COG2176 is ------v--b----gp-----Number of proteins in this genome belonging to this COG is 1","***** IPB003141 (PHP domain N-terminal region) with a combined E-value of 1.3e-28. IPB003141A 339-376 IPB003141B 969-984 IPB003141C 1284-1294","Residues 1051-1188 are 54% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD004180) which is seen in DPO3_THEMA.Residues 1284-1441 are 41% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD004426) which is seen in DPO3_THEMA.Residues 1151-1193 are 93% similar to a (DNA POLYMERASE POLC-TYPE TRANSFERASE) protein domain (PD405601) which is seen in DPO3_STRPY.Residues 502-581 are 93% similar to a (DNA POLYMERASE III EPSILON) protein domain (PD006730) which is seen in DPO3_STRPY.Residues 424-500 are 83% similar to a (DNA POLYMERASE III COMPLETE) protein domain (PD002851) which is seen in DPO3_STRPY.Residues 335-403 are 75% similar to a (DNA POLYMERASE III DNA-DIRECTED) protein domain (PD001693) which is seen in DPO3_STRPY.Residues 1283-1363 are 88% similar to a (DNA POLYMERASE POLC-TYPE TRANSFERASE) protein domain (PD241329) which is seen in DPO3_STRPY.Residues 5-330 are 68% similar to a (DNA POLYMERASE POLC-TYPE TRANSFERASE) protein domain (PD024654) which is seen in DPO3_STRPY.Residues 1364-1461 are 87% similar to a (DNA POLYMERASE POLC-TYPE TRANSFERASE) protein domain (PD390614) which is seen in DPO3_STRPY.Residues 1194-1282 are 95% similar to a (DNA POLYMERASE POLC-TYPE TRANSFERASE) protein domain (PD011868) which is seen in DPO3_STRPY.Residues 889-980 are 76% similar to a (DNA POLYMERASE POLC-TYPE TRANSFERASE) protein domain (PD275068) which is seen in DPO3_STRPY.Residues 981-1042 are 95% similar to a (DNA POLYMERASE POLC-TYPE TRANSFERASE) protein domain (PD394726) which is seen in DPO3_STRPY.Residues 495-591 are 50% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD369841) which is seen in DPO3_BACSU.Residues 424-493 are 42% similar to a (DNA POLYMERASE III PLASMID) protein domain (PD385474) which is seen in DP3A_RHOCA.Residues 617-881 are 78% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD003212) which is seen in DPO3_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 09:57:37 2006","Fri Dec 14 15:33:11 2001","Thu Aug 24 09:57:37 2006","Thu Mar 28 10:32:37 2002","Fri Dec 14 15:33:11 2001","Fri Dec 14 15:33:11 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0110 is paralogously related (blast p-value < 1e-3) to SMu1200, an epsilon subunit, and to SMu1091, an alpha subunit.","Fri Dec 14 15:39:18 2001","","No significant hits to the NCBI PDB database.","SMU.123","","Residues 339 to 404 (E-value = 5.9e-29) place SMu0110 in the PHP_N family which is described as PHP domain N-terminal region (PF02231)Residues 425 to 581 (E-value = 7.4e-41) place SMu0110 in the Exonuc_X-T family which is described as Exonuclease (PF00929)Residues 613 to 750 (E-value = 4.7e-19) place SMu0110 in the PHP_C family which is described as PHP domain C-terminal region (PF02811)","Thu Aug 24 09:57:37 2006","24378642","","","Bruck I, O'Donnell M.The DNA replication machine of a gram-positive organism.J Biol Chem. 2000 Sep 15;275(37):28971-83.PMID: 10878011Hammond RA, Barnes MH, Mack SL, Mitchener JA, Brown NC.Bacillus subtilis DNA polymerase III: complete sequence, overexpression, and characterization of the polC gene.Gene. 1991 Feb 1;98(1):29-36.PMID: 1901559","","Thu Aug 24 09:57:37 2006","1","","","SMU.123","189" "SMu0111","127505","127954","450","ATGGTCATAGAGAGGAGTTGTATGGGTGATTTAGATAAGAATCCTGCAGTTAAAGCTATGGTTGTTTTTCGCAAGGCTATGCGAACAATTGATGCGCAAGTTGCTCCAAGCTATAAAAACAATGGTTTAACACAAACCCAGTTTGCCGTTTTGGATGTTCTTTATGCTAAAGGAGAGATGACCATCAGTCGTTTGATTGCTTCTATACTGGCGACGTCTGGCAATATGACGGTTGTGATTAAAAATATGGAACGTAATGGTTGGATTTACCGGAGCCCAAATCCAGATGACAGACGTGCCTCGGTTGTTGGTCTGACGGAAGTTGGCAAACAATTGATTCAAAAAGCTTTGCCTGATCATATTGCTATGGTAGAAGCTGCTTTTTCTGTAATGACAGAAGAGGAGCAGTTAGTCCTAATAGATCTGTTGAAAAAGTTTAAATCTCTTTAA","9.70","3.18","16544","MVIERSCMGDLDKNPAVKAMVVFRKAMRTIDAQVAPSYKNNGLTQTQFAVLDVLYAKGEMTISRLIASILATSGNMTVVIKNMERNGWIYRSPNPDDRRASVVGLTEVGKQLIQKALPDHIAMVEAAFSVMTEEEQLVLIDLLKKFKSL","127951","","transcriptional regulator, MarR family","Cytoplasm","Limited matches to transcriptional regulators and conserved hypothetical proteins. Residues 8-149 are 62% similar to gi|15675758 of S.pyogenes. Residues 22-145 are 36% similar to a MarR protein from B.subtilis (gi|16078399).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1910 (4e-44).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PR00598	$\"[77-92]T$ $\"[96-112]T$ $\"[126-146]T$	HTHMARR
PF01047	$\"[43-112]T$	MarR
SM00347	$\"[36-136]T$	HTH_MARR
PS50995	$\"[13-148]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[15-125]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[19-146]T$	SSF46785

","BeTs to 6 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class: KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","***** IPB000835 (Bacterial regulatory protein, MarR family) with a combined E-value of 1.4e-11. IPB000835 76-109","Residues 61-145 are 32% similar to a (TRANSCRIPTION DNA-BINDING REGULATION COMPLETE PROTEOME) protein domain (PD001097) which is seen in Q9KZ35_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:06:12 2002","Tue Oct 8 08:06:12 2002","Mon Dec 17 13:54:05 2001","Tue Oct 8 08:05:12 2002","Mon Dec 17 13:49:23 2001","Mon Dec 17 13:49:23 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0111 is paralogously related (blast p-value < 1e-3) to SMu0400, a conserved hypothetical protein, and to SMu1591, SMu0935, and SMu1004, all thought to be transcriptional regulators.","Mon Dec 17 13:56:35 2001","","No significant hits to the NCBI PDB database.","SMU.124","","Residues 43 to 146 (E-value = 3.7e-31) place SMu0111 in the MarR family which is described as MarR family (PF01047)","Mon Dec 17 13:49:23 2001","24378643","","","","","","1","","","SMU.124","979" "SMu0112","128033","128587","555","ATGTCAAAAAGAATTTTATTTATTGTCGGTTCGTTTAGTGAAGGATCATTCAACCGTCAATTAGCTAAAAAAGCAGAAACGATTATTGGTGATCGGGCTCAAGTTTCTTATTTAAGTTATGATCGTGTCCCGTTTTTTAATCAGGATTTAGAAACGTCAGTACATCCCGAGGTGGCACATGCACGAGAAGAAGTTCAAGAAGCAGATGCTATTTGGATTTTTTCACCCGTTTACAACTATGCTATTCCGGGCCCTGTCAAAAACCTGCTTGATTGGCTGTCGCGCTCTCTTGACTTATCAGATCCAACAGGACCTTCAGTGCTTCAAGATAAGATTGTGACGGTTTCCTCCGTTGCTAATGGGGCGTCTCCAGAGGAAGTTTTTGAGGATTACCGTTCTTTACTTCCTTTTATTCGTATGCATTTGGTAGATCAATTAACAGGTGTTCCAATTAACTCAGAAGCTTGGAGCACAGGTATTCTTAAAGTATCAGCAGAAAAATTAGCAGAATTATCTGCTCAGGCAGATGCTCTATTGTCTGCTGTAGAAAATTAG","4.50","-9.27","20295","MSKRILFIVGSFSEGSFNRQLAKKAETIIGDRAQVSYLSYDRVPFFNQDLETSVHPEVAHAREEVQEADAIWIFSPVYNYAIPGPVKNLLDWLSRSLDLSDPTGPSVLQDKIVTVSSVANGASPEEVFEDYRSLLPFIRMHLVDQLTGVPINSEAWSTGILKVSAEKLAELSAQADALLSAVEN","128584","","conserved hypothetical protein","Cytoplasm, Membrane","Several matches to conserved hypothetical proteins. Residues 3-182 are 50% similar to gi|15675757 of S.pyogenes. Residues 1-183 are 49% similar to gi|15901389 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1082 (2e-07).","

InterPro
IPR005025
Domain

NADPH-dependent FMN reductase
PF03358	$\"[4-124]T$	FMN_red

InterPro
IPR014479
Family

NAD(P)H-dependent FMN reductase
PIRSF016214	$\"[3-183]T$	SSUE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[4-183]T$	G3DSA:3.40.50.360
SSF52218	$\"[1-178]T$	SSF52218

","BeTs to 3 clades of COG0431COG name: Predicted flavoproteinFunctional Class:� RThe phylogenetic pattern of COG0431 is ----y--cebr---gp-----Number of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 1-88 are 43% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH) protein domain (PD009603) which is seen in Q9RD22_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:20:14 2002","Mon Dec 17 14:00:20 2001","Mon Dec 17 14:03:20 2001","Mon Dec 17 14:00:20 2001","","Mon Dec 17 14:00:20 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0112 is paralogously related (blast p-value < 1e-3) to SMu0997, SMu0162, SMu1282, SMu0998, and SMu0161, all conserved hypothetical proteins except SMu0162 that is a predicted fumarate reductase.. ","Mon Dec 17 14:03:20 2001","","No significant hits to the NCBI PDB database.","SMU.125","","Residues 3 to 180 (E-value = 1.8e-17) place SMu0112 in the FMN_red family which is described as NADPH-dependent FMN reductase (PF03358)","Mon Dec 17 14:00:20 2001","24378644","","","","","","1","","","SMU.125","" "SMu0113","128963","129958","996","ATGGCAAGAAAAATTTTGGAGGTCATTATAGCAATGTTATCTAAAAAACAATATTTGGATATGTTTTTAAAAATGCAGCGTATCCGTGATGTCGATACAAAACTCAATAAATTAGTTCGTCGTGGTTTCGTACAAGGTATGACACACTTTTCAGTAGGAGAAGAGGCGGCTTCGGTTGGTGCGATTCAAGGCTTGACTGATCAGGATATTATCTTTTCAAATCACCGTGGACATGGTCAAACCATTGCAAAAGGGATTGACATTCCTGCTATGTTTGCAGAATTAGCCGGTAAGGCAACGGGTTCTTCAAAAGGTCGTGGTGGTTCTATGCACTTGGCAAATCTTGAAAAAGGAAACTATGGGACCAATGGTATTGTTGGCGGGGGTTATGCCTTAGCAGTCGGTGCTGCTTTGACACAGCAATATGACAATACGGGAAATATTGTTGTCGCCTTTTCAGGAGACTCGGCAACTAATGAAGGCTCTTTCCATGAGTCTGTTAATTTGGCAGCTGTCTGGAATTTACCGGTTATCTTCTTTATTATTAATAATCGTTATGGTATCTCAACAGATATCAATTATTCTACTAAGATTTCACATCTTTATTTACGTGCTGATGCTTATGGTATTCCTGGACATTATGTTGAAGATGGTAATGATGTCATTGCAGTTTATGAAAAAATGCAGGAAGTCATTGATTATGTGCGTTCAGGAAATGGGCCAGCTCTTGTTGAAGTGGAATCTTATCGTTGGTTCGGACATTCTACTGCTGATGCAGGAGCTTACCGTACAAAAGAAGAAGTAGATGCTTGGAAAGCTAAAGATCCTCTCAAGAAATACCGCACTTATCTAACAGAAAATAAGATTGCAACAGATGAGGAACTTGATATGATTGAAAAAGAAGTCGCACAGGAAATTGAGGATGCAGTGAAATTTGCCCAAGATAGCCCTGAACCAGAGCTTTCTGTAGCTTTTGAAGATGTTTGGGTAGATTAG","5.00","-11.05","36437","MARKILEVIIAMLSKKQYLDMFLKMQRIRDVDTKLNKLVRRGFVQGMTHFSVGEEAASVGAIQGLTDQDIIFSNHRGHGQTIAKGIDIPAMFAELAGKATGSSKGRGGSMHLANLEKGNYGTNGIVGGGYALAVGAALTQQYDNTGNIVVAFSGDSATNEGSFHESVNLAAVWNLPVIFFIINNRYGISTDINYSTKISHLYLRADAYGIPGHYVEDGNDVIAVYEKMQEVIDYVRSGNGPALVEVESYRWFGHSTADAGAYRTKEEVDAWKAKDPLKKYRTYLTENKIATDEELDMIEKEVAQEIEDAVKFAQDSPEPELSVAFEDVWVD","129955","For other 'aco' genes see SMu1297 (acoB);SMu1296 (acoC); SMu1298 (acoA) and SMu1299 (acoL).For other 'acu' genes see SMu1516 (acuB).For other 'adh' genes see SMu0107 (adh);SMu0114 (adhB); SMu0115 (adhC); SMu0116 (adhD); SMu0131 (adhE); SMu1698 (adhB) and SMu1299 (adhD).For the beta subunit, see SMu0114 and SMu1297.From Genbank:[gi:113136] This enzyme catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde.In vitro the alpha subunit is probably the catalytic subunit of the enzyme. ","acetoin dehydrogenase (TPP-dependent) E1 component alpha subunit","Cytoplasm","Several matches in gapped BLAST to acetoin dehydrogenase alpha subunits. Residues 13-331 are 69% similar to gi13622175 of S.pyogenes. Residues 10-331 are 54% similar to the subunit from S.pneumoniae (gi15903095).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0878 (1e-148).","

InterPro
IPR001017
Domain

Dehydrogenase, E1 component
PF00676	$\"[23-322]T$	E1_dh

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.970	$\"[13-329]T$	G3DSA:3.40.50.970
PTHR11516	$\"[1-331]T$	PTHR11516
SSF52518	$\"[5-331]T$	SSF52518

","BeTs to 7 clades of COG1071COG name: Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunitFunctional Class: CThe phylogenetic pattern of COG1071 is ----y--c-BR---gp--INxNumber of proteins in this genome belonging to this COG is 2","***** IPB001017 (Dehydrogenase, E1 component) with a combined E-value of 5.4e-59. IPB001017A 20-32 IPB001017B 46-78 IPB001017C 94-113 IPB001017D 152-190 IPB001017E 211-224 IPB001017F 239-259","Residues 139-254 are 48% similar to a (SYNTHASE THIAMINE DEHYDROGENASE PYROPHOSPHATE PYRUVATE) protein domain (PD000580) which is seen in O31404_BACSU.Residues 13-113 are 45% similar to a (PYRUVATE DEHYDROGENASE ALPHA SUBUNIT E1 OXIDOREDUCTASE) protein domain (PD001490) which is seen in Q9KES3_BACHD.Residues 275-329 are 43% similar to a (PYRUVATE DEHYDROGENASE SUBUNIT ALPHA) protein domain (PD330780) which is seen in Q9MAM6_ARATH.Residues 258-330 are 39% similar to a (PROTEOME ACETOIN COMPLETE ALPHA-SUBUNIT) protein domain (PD351860) which is seen in O31404_BACSU.Residues 249-314 are 40% similar to a (DEHYDROGENASE ALPHA SUBUNIT PYRUVATE) protein domain (PD186280) which is seen in Q9Y8I5_HALVO.Residues 275-329 are 41% similar to a (PYRUVATE DEHYDROGENASE ALPHA SUBUNIT) protein domain (PD229734) which is seen in ODPA_PEA.Residues 250-330 are 35% similar to a (SUBUNIT ALPHA OXIDOREDUCTASE) protein domain (PD194664) which is seen in Q57102_PELCA.Residues 275-328 are 48% similar to a (DEHYDROGENASE PYRUVATE ALPHA E1) protein domain (PD347854) which is seen in Q9KES3_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 13:35:38 2006","Mon Dec 17 14:06:41 2001","Mon Sep 11 13:32:55 2006","Thu Mar 28 14:28:32 2002","Mon Dec 17 14:06:41 2001","Mon Dec 17 14:06:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0113 is paralogously related (blast p-value < 1e-3) to SMu1298, another predicted adhA, and to SMu0262, a predicted transketolase.","Mon Dec 17 14:20:27 2001","Mon Sep 11 13:32:55 2006","pdb1DTWA Chain A, Human Branched-Chain Alpha-Keto Acid Dehydr... 136 4e-033pdb1QS0A Chain A, Crystal Structure Of Pseudomonas Putida 2-O... 89 1e-018","SMU.127","","Residues 23 to 322 (E-value = 2.3e-107) place SMu0113 in the E1_dh family which is described as Dehydrogenase E1 component (PF00676)","Mon Dec 17 14:06:41 2001","24378645","","","Ali NO, Bignon J, Rapoport G, Debarbouille M.Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis.J Bacteriol. 2001 Apr;183(8):2497-504.PMID: 11274109Huang M, Oppermann-Sanio FB, Steinbuchel A.Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway.J Bacteriol. 1999 Jun;181(12):3837-41.PMID: 10368162","","Mon Dec 17 14:20:27 2001","1","","","SMU.127","335" "SMu0114","130090","131103","1014","ATGAGGAGAAAGAGATATATGTCAGAAACAAAAGTAGTAGCCTTACGGGAAGCTATCAATCTTGCTATGAGCGAGGAAATGCGTAAGGACGAAAAAATTATTTTGATGGGTGAAGATGTCGGTATTTATGGTGGTGACTTTGGAACTTCTGTTGGTATGCTGGCTGAATTTGGTGAAAAGCGTGTTAAAGATACCCCTATTTCAGAAGCAGCCATTGCAGGATCTGCAGTAGGTGCCGCTCAAACTGGACTTCGTCCTATTGTTGATTTGACCTTTATGGACTTTGTGACTATTGCCATGGATGCTATTGTTAATCAAGGTGCTAAAGCCAATTATATGTTTGGCGGCGGACTTAAAACGCCTGTAACCTTTCGTGTGGCCTCAGGCTCAGGTATCGGCTCAGCAGCGCAGCATTCTCAGTCACTAGAAGCTTGGTTAACTCATATTCCGGGAATCAAGGTGGTTGCGCCTGGCACAGTCAATGATGCTAAAGCCTTGCTCAAATCTGCTATTCGTGATAATAATATCGTTATTTTCATGGAACCAAAAGCGCTTTATGGCAAAAAAGAAGAGGTCAATTTAGATCCTGATTTTTATATTCCGCTTGGTAAAGGCGAAATTAAGCGCGAGGGAACAGATGTTACCATTGTGTCTTATGGTCGTATGCTGGAACGCGTTCTCAAAGCCGCTGAGGAAGTGGCGGCTGAAGATATCAGTGTTGAAGTTGTTGACCCGCGTACCCTTATTCCGCTTGATAAAGACTTAATTATTAATTCTGTGAAAAAGACGGGTAAGGTTATCCTAGTTAATGATGCTTATAAAACAGGTGGTTTCATTGGTGAAATAGCATCAGTGATTACTGAAAGCGAAGCATTTGATTATTTAGATGCACCAGTGCTTCGTCTCGCTTCTGAGGATGTGCCTGTTCCCTATTCTCATGTTCTCGAAACAGCCATTTTACCAGATGTGGCAAAAATTAAAGAAGCTATCTATAAACAAGTCAGGAAAAGATAG","5.40","-4.25","36536","MRRKRYMSETKVVALREAINLAMSEEMRKDEKIILMGEDVGIYGGDFGTSVGMLAEFGEKRVKDTPISEAAIAGSAVGAAQTGLRPIVDLTFMDFVTIAMDAIVNQGAKANYMFGGGLKTPVTFRVASGSGIGSAAQHSQSLEAWLTHIPGIKVVAPGTVNDAKALLKSAIRDNNIVIFMEPKALYGKKEEVNLDPDFYIPLGKGEIKREGTDVTIVSYGRMLERVLKAAEEVAAEDISVEVVDPRTLIPLDKDLIINSVKKTGKVILVNDAYKTGGFIGEIASVITESEAFDYLDAPVLRLASEDVPVPYSHVLETAILPDVAKIKEAIYKQVRKR","131100","For other 'adh' genes see SMu0107 (adh);SMu0113 (adhA); SMu0115 (adhC); SMu0116 (adhD); SMu0131 (adhE); SMu1698 (adhB) and SMu1299 (adhD).For the alpha subunit, see SMu0113 and SMu1298.","acetoin dehydrogenase (TPP-dependent) E1 component beta subunit","Cytoplasm","Several matches in gapped BLAST to acetion dehydrogenase beta subunit sequences, e.g. residues 7-336 are 81% similar to a subunit from S.pyogenes (gi13622176). Residues 9-336 are 65% similar to gi15903094 of S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0879 (1e-157).","

InterPro
IPR005475
Domain

Transketolase, central region
PF02779	$\"[11-188]T$	Transket_pyr

InterPro
IPR005476
Domain

Transketolase, C-terminal
PF02780	$\"[203-326]T$	Transketolase_C

InterPro
IPR009014
Domain

Transketolase, C-terminal-like
G3DSA:3.40.50.920	$\"[206-336]T$	Transketo_C_like
SSF52922	$\"[197-335]T$	Transketo_C_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.970	$\"[9-205]T$	G3DSA:3.40.50.970
PTHR11624	$\"[47-332]T$	PTHR11624
PTHR11624:SF21	$\"[47-332]T$	PTHR11624:SF21
SSF52518	$\"[9-213]T$	SSF52518

","BeTs to 7 clades of COG0022COG name: Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunitFunctional Class: CThe phylogenetic pattern of COG0022 is ----y--c-Br---gp--INxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 82-277 are 58% similar to a (SYNTHASE THIAMINE DEHYDROGENASE PYROPHOSPHATE PYRUVATE) protein domain (PD000580) which is seen in Q9KES2_BACHD.Residues 292-330 are 53% similar to a (PYRUVATE BETA DEHYDROGENASE SUBUNIT) protein domain (PD163062) which is seen in ODPB_RHIME.Residues 141-186 are 58% similar to a (SUBUNIT BETA OXIDOREDUCTASE DEHYDROGENASE) protein domain (PD344304) which is seen in ODPB_BACSU.Residues 284-332 are 51% similar to a (PYRUVATE DEHYDROGENASE BETA E1) protein domain (PD006394) which is seen in Q9PKE8_CHLMU.Residues 50-139 are 46% similar to a (BETA DEHYDROGENASE SUBUNIT E1) protein domain (PD247144) which is seen in Q46143_BBBBB.Residues 223-276 are 50% similar to a (BETA ALPHA-KETO SUBUNIT BRANCHED-CHAIN) protein domain (PD166298) which is seen in Q9RPS4_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 13:47:41 2006","Mon Dec 17 14:22:49 2001","Mon Sep 11 13:47:41 2006","Thu Apr 4 14:10:52 2002","","Mon Dec 17 14:22:49 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0114 is paralogously related (blast p-value < 1e-3) to SMu1297, also a predicted acetoin dehydrogenase beta subunit.","Mon Dec 17 15:06:22 2001","Mon Sep 11 13:47:41 2006","pdb1DTWB Chain B, Human Branched-Chain Alpha-Keto Acid Dehydr... 198 7e-052pdb1QS0B Chain B, Crystal Structure Of Pseudomonas Putida 2-O... 197 2e-051","SMU.128","","Residues 13 to 188 (E-value = 6e-66) place SMu0114 in the Transket_pyr family which is described as Transketolase, pyridine binding domain (PF02779)Residues 203 to 326 (E-value = 7.6e-54) place SMu0114 in the Transketolase_C family which is described as Transketolase, C-terminal domain (PF02780)","Mon Sep 11 13:47:41 2006","24378646","","","Ali NO, Bignon J, Rapoport G, Debarbouille M.Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis.J Bacteriol. 2001 Apr;183(8):2497-504.PMID: 11274109Huang M, Oppermann-Sanio FB, Steinbuchel A.Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway.J Bacteriol. 1999 Jun;181(12):3837-41.PMID: 10368162","","Mon Dec 17 14:23:48 2001","1","","","SMU.128","336" "SMu0115","131203","132570","1368","ATGGCAGTCGAAATTATTATGCCTAAACTTGGTGTTGATATGCAGGAAGGCGAAATCATCGAGTGGAAAAAACAAGAAGGTGATGAGGTCAAAGAAGGGGAGATCCTCCTTGAGATTATGTCTGACAAGACCAATATGGAAATCGAAGCTGAGGATTCAGGTGTCCTGCTTAAGATTGTTAAAGGAAATGGTCAAGTTGTTCCTGTAACTGAGGTCATTGGTTATATTGGTCAAGCAGGTGAAGTTCTTGAAATAGCTGATGTTCCTGCAAGTACAGTTCCTAAAGAAAATAGTGCAGCACCTGCTGAAAAAACAAAAGCAATGTCTTCTCCGACAGTTGCAGCAGCCCCTCAAGGAAAGATTCGAGCAACACCAGCAGCTCGTAAGGCGGCTCGTGATCTGGGAGTTAACCTGAATCAGGTTTCAGGGACAGGCGCTAAAGGCCGTGTTCACAAGGAAGATGTTGAAAGCTTTAAAGCAGCTCAGCCTAAAGCAACACCATTAGCTAGGAAAATTGCTATAGATAAAGGTATTGATCTAGCCAGTGTCTCAGGAACAGGTTTTGGCGGCAAAATTATCAAGGAAGATATTTTAAATCTGTTTGAGGCAGCTCAGCCTGTTAATGATGTGTCAGATCCTGCTAAAGAAGCAGCTGCCTTACCAGAGGGTGTTGAAGTCATTAAGATGTCTGCCATGCGTAAGGCAGTGGCTAAAAGCATGGTCAATTCTTACCTGACAGCTCCAACTTTTACTCTCAATTATGACATTGACATGACTGAGATGATTGCGTTGCGTAAAAAGTTAATTGATCCTATCATGGAAAAAACAGGTTTTAAAGTTAGCTTCACAGATTTGATTGGTCTGGCAGTCGTAAAAACCTTAATGAAACCAGAACATCGTTACCTCAATGCTTCACTCATTAATGACGCGACTGAGATTGAACTTCATCAATTTGTTAACCTTGGTATCGCCGTTGGACTTGATGAAGGACTGTTAGTACCTGTTGTTCATGGTGCAGATAAGATGAGCTTGTCAGATTTTGTTATAGCTTCAAAGGATGTCATTAAGAAAGCTCAGACCGGTAAATTAAAAGCCACTGAAATGTCTGGTTCAACCTTTTCCATTACAAACTTGGGGATGTTTGGCACTAAGACTTTCAACCCCATTATCAATCAGCCAAATTCGGCTATTTTGGGTGTAGGAGCAACTATCCAAACGCCAACTGTTGTGGATGGTGAAATTAAGATTCGTCCAATCATGGCACTGTGCTTGACCATCGATCACCGCTTGGTTGATGGCATGAACGGCGCTAAGTTCATGGTTGATCTTAAAAAACTGATGGAAAATCCATTTACATTATTGATTTGA","5.50","-5.80","48664","MAVEIIMPKLGVDMQEGEIIEWKKQEGDEVKEGEILLEIMSDKTNMEIEAEDSGVLLKIVKGNGQVVPVTEVIGYIGQAGEVLEIADVPASTVPKENSAAPAEKTKAMSSPTVAAAPQGKIRATPAARKAARDLGVNLNQVSGTGAKGRVHKEDVESFKAAQPKATPLARKIAIDKGIDLASVSGTGFGGKIIKEDILNLFEAAQPVNDVSDPAKEAAALPEGVEVIKMSAMRKAVAKSMVNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMEKTGFKVSFTDLIGLAVVKTLMKPEHRYLNASLINDATEIELHQFVNLGIAVGLDEGLLVPVVHGADKMSLSDFVIASKDVIKKAQTGKLKATEMSGSTFSITNLGMFGTKTFNPIINQPNSAILGVGATIQTPTVVDGEIKIRPIMALCLTIDHRLVDGMNGAKFMVDLKKLMENPFTLLI","132567","For other 'adh' genes see SMu0107 (adh);SMu0113 (adhA); SMu0114 (adhB); SMu0116 (adhD); SMu0131 (adhE); SMu1698 (adhB) and SMu1299 (adhD).","dihydrolipoamide S-acetyltransferase","Cytoplasm, Extracellular","Several matches in gapped BLAST to dihydrolipoamide S-acetyltransferase sequences. Residues 1-455 are 75% similar to the enzyme from S.pyogenes (gi15675027) and 41% similar to the enzyme from B.halodurans (gi15613341).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0880 (0.0).","

InterPro
IPR000089
Domain

Biotin/lipoyl attachment
PF00364	$\"[3-76]T$	Biotin_lipoyl
PS50968	$\"[3-76]T$	BIOTINYL_LIPOYL

InterPro
IPR001078
Domain

Catalytic domain of components of various dehydrogenase complexes
PD001115	$\"[375-446]T$	2Oxoacid_dh
PF00198	$\"[221-455]T$	2-oxoacid_dh

InterPro
IPR003016
Binding_site

2-oxo acid dehydrogenase, lipoyl-binding site
PS00189	$\"[27-56]T$	LIPOYL

InterPro
IPR004167
Domain

E3 binding
PF02817	$\"[123-159]T$ $\"[165-201]T$	E3_binding

InterPro
IPR011053
Domain

Single hybrid motif
SSF51230	$\"[1-98]T$	Hybrid_motif

noIPR
unintegrated

unintegrated
G3DSA:2.40.50.100	$\"[4-81]T$	G3DSA:2.40.50.100
G3DSA:3.30.559.10	$\"[210-455]T$	G3DSA:3.30.559.10
G3DSA:4.10.320.10	$\"[122-162]T$ $\"[164-204]T$	G3DSA:4.10.320.10
PTHR23151	$\"[3-158]T$ $\"[199-428]T$	PTHR23151
PTHR23151:SF19	$\"[3-158]T$ $\"[199-428]T$	PTHR23151:SF19
SSF47005	$\"[112-162]T$ $\"[163-204]T$	SSF47005
SSF52777	$\"[221-455]T$	SSF52777

","BeTs to 8 clades of COG0508COG name: Dihydrolipoamide acyltransferasesFunctional Class: CThe phylogenetic pattern of COG0508 is ----Y--cEBRH--gp--INXNumber of proteins in this genome belonging to this COG is 2","***** IPB001078 (2-Oxo acid dehydrogenase acyltransferase catalytic domain) with a combined E-value of 1.7e-72. IPB001078A 22-54 IPB001078B 125-155 IPB001078C 279-300 IPB001078D 358-400 IPB001078E 419-455***** IPB003016 (2-oxo acid dehydrogenases acyltransferase component lipoyl binding site) with a combined E-value of 4.4e-14. IPB003016 25-59***** IPB000089 (Biotin / Lipoyl attachment) with a combined E-value of 1.7e-11. IPB000089A 320-339 IPB000089B 374-393","Residues 7-73 are 52% similar to a (BIOTIN DIHYDROLIPOAMIDE LIPOYL CARBOXYLASE TRANSFERASE) protein domain (PD000268) which is seen in Q9KES1_BACHD.Residues 77-168 are 33% similar to a (COMPONENT TRANSFERASE PYRUVATE) protein domain (PD168210) which is seen in ODP2_ACHLA.Residues 89-158 are 43% similar to a (TRANSFERASE DIHYDROLIPOAMIDE LIPOYL) protein domain (PD293828) which is seen in ODP2_YEAST.Residues 77-167 are 36% similar to a (PYRUVATE PROTEOME COMPONENT TRANSFERASE) protein domain (PD394956) which is seen in Q9YBC6_AERPE.Residues 233-455 are 42% similar to a (DIHYDROLIPOAMIDE TRANSFERASE LIPOYL DEHYDROGENASE E2) protein domain (PD001115) which is seen in Q9KES1_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:18:36 2007","Mon Dec 17 15:15:15 2001","Thu Aug 3 08:37:21 2006","Thu Apr 4 14:17:47 2002","Mon Dec 17 15:08:58 2001","Mon Dec 17 15:08:58 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0115 is paralogously related (blast p-value < 1e-3) to SMu1296, a predicted dihydrolipoamide acetyltransferase, E2 component, and to SMu0116, a predicted dihydrolipoamide dehydrogenase.","Mon Dec 17 15:17:48 2001","Thu Aug 3 08:37:21 2006","pdb1B5SA Chain A, Dihydrolipoyl Transacetylase (E.C.2.3.1.12)... 166 5e-042pdb1E2O Catalytic Domain From Dihydrolipoamide Succinyltra... 141 2e-034pdb1DPC Dihydrolipoyl Transacetylase (E.C.2.3.1.12) (Catal... 109 5e-025","SMU.129","","Residues 3 to 76 (E-value = 1.2e-21) place SMu0115 in the Biotin_lipoyl family which is described as Biotin-requiring enzyme (PF00364)Residues 123 to 159 (E-value = 8.3e-16) place SMu0115 in the E3_binding family which is described as e3 binding domain (PF02817)Residues 165 to 201 (E-value = 1.3e-13) place SMu0115 in the E3_binding family which is described as e3 binding domain (PF02817)Residues 221 to 455 (E-value = 4.9e-118) place SMu0115 in the 2-oxoacid_dh family which is described as 2-oxoacid dehydrogenases acyltransferase (catalytic domain) (PF00198)","Thu Aug 3 08:37:21 2006","24378647","","","","","","1","","","SMU.129","103" "SMu0116","132644","134389","1746","ATGGCAGTCGAAATTATTATGCCTAAACTCGGTGTTGATATGCAGGAAGGCGAAATCATCGAGTGGAAAAAACAAGAAGGTGATGAGGTCAAAGAAGGGGATATCCTCCTTGAAATCATGTCTGACAAGACCAATATGGAAATTGAAGCTGAGGATTCAGGTGTCCTGCTCAAAATTGTTAAAGGAAATGGTCAAGTTGTCCCTGTGACTGAGGTCATTGGTTATATTGGTTCTGCTGGTGAAACGATTGAAACAAATGCAGCGCCAGCAGCTTCAGCTGATGATCTCAAAGCAGCGGGTCTTGAAGTTCCTGATACTTTAGGCGAGTCAGCAGCACCAGCAGCTCAAAAAACTCCGCTTGCTGATGATGAGTATGATATGATTGTCGTTGGTGGTGGTCCTGCTGGTTATTATGCTGCTATTCGCGGTGCACAATTGGGCGGCAAGGTTGCTATCGTCGAAAAATCAGAATTTGGAGGGACTTGTTTAAATAAAGGCTGCATTCCAACTAAAACTTATCTTAAGAATGCTGAAATCCTTGATGGCATCAAAATTGCAGCGGGTCGCGGTATTAATTTTGCTTCAACCAACTATACCATTGACATGGACAAAACGGTTGCCTTTAAAGATACCGTTGTTAAAACATTGACAAGTGGGGTTCAGGGTCTTCTTAAAGCCAATAAAGTGACTATTTTCAATGGTCTCGGTCAGGTTAATCCTGATAAGACAGTGACTGTCGGTTCGGAAACGATTAAAGGACATAATATTATCCTTGCAACAGGTTCAAAAGTGTCTCGTATTAATATTCCGGGAATTGATTCACCTCTTGTTTTAACATCGGATGATATTCTTGATCTTCGTGAAATTCCAAAGTCACTTGCTGTTATGGGCGGTGGTGTTGTCGGCATTGAACTCGGTCTTGTTTACGCTTCCTATGGTACAGAAGTGACTGTTATTGAAATGGCTGATCGCATTATTCCTGCTATGGACAAGGAAGTATCGCTTGAACTGCAAAAAATTCTATCCAAGAAAGGAATGAACATTAAGACTTCTGTTGGTGTGGCTGAAATTGTTGAAGCTAACAATCAATTAACGCTGAAACTCAATGACGGCTCTGAAGTTGTGGCTGAAAAGGCCCTGCTTTCTATTGGTCGTGTCCCACAATTAAGCGGTTTAGAAAATCTTAATCTGGAACTTGAACGCGGTCGCATCAAAGTGGACGATTATCAGGAAACCTCTATTTCAGGTATTTATGCCCCGGGTGATGTTAATGGAAGAAAGATGTTAGCGCATGCTGCCTATCGTATGGGTGAAGTAGCTGCCGAAAATGCTATCTGGGGAAATGTTCGTAAGGCTAACCTGAAATATACACCAGCAGCTGTTTACACCCATCCAGAGGTTGCTATGTGCGGTATTACTGAAGAACAAGCCCGTCAAGAATATGGAAACGTCTTAGTTGGGAAATCCTCTTTTTCAGGAAATGGACGTGCGATCGCTTCTAATGAAGCACAAGGATTTGTCAAAGTTGTCGCAGATGCTAAATACCATGAAATTCTTGGAGTCCATATTATTGGACCAGCAGCTGCTGAGATGATTAATGAAGCCTCAACGATTATGGAAAATGAGTTGACGGTTGATGAGCTGCTACGTTCTATTCATGGCCATCCTACCTTCTCGGAGGTTATGTATGAAGCCTTTGCAGACGTCCTTGGCGAAGCTATCCATAACCCGCCAAAGCGTCGTTAA","4.70","-23.14","61738","MAVEIIMPKLGVDMQEGEIIEWKKQEGDEVKEGDILLEIMSDKTNMEIEAEDSGVLLKIVKGNGQVVPVTEVIGYIGSAGETIETNAAPAASADDLKAAGLEVPDTLGESAAPAAQKTPLADDEYDMIVVGGGPAGYYAAIRGAQLGGKVAIVEKSEFGGTCLNKGCIPTKTYLKNAEILDGIKIAAGRGINFASTNYTIDMDKTVAFKDTVVKTLTSGVQGLLKANKVTIFNGLGQVNPDKTVTVGSETIKGHNIILATGSKVSRINIPGIDSPLVLTSDDILDLREIPKSLAVMGGGVVGIELGLVYASYGTEVTVIEMADRIIPAMDKEVSLELQKILSKKGMNIKTSVGVAEIVEANNQLTLKLNDGSEVVAEKALLSIGRVPQLSGLENLNLELERGRIKVDDYQETSISGIYAPGDVNGRKMLAHAAYRMGEVAAENAIWGNVRKANLKYTPAAVYTHPEVAMCGITEEQARQEYGNVLVGKSSFSGNGRAIASNEAQGFVKVVADAKYHEILGVHIIGPAAAEMINEASTIMENELTVDELLRSIHGHPTFSEVMYEAFADVLGEAIHNPPKRR","134386","For other 'adh' genes see SMu0107 (adh);SMu0113 (adhA); SMu0114 (adhB); SMu0115 (adhC); SMu0131 (adhE); SMu1698 (adhB) and SMu1299 (adhD).","dihydrolipoamide dehydrogenase","Cytoplasm","Several matches in gapped BLAST to dihydrolipoamide dehydrogenasesequences. Residues 1-581 are 78% similar to the enzyme from S.pyogenes (gi15675028). Residues 1-580 are 55% similar to gi17223676 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0881 (0.0).","

InterPro
IPR000089
Domain

Biotin/lipoyl attachment
PF00364	$\"[3-76]T$	Biotin_lipoyl
PS50968	$\"[3-76]T$	BIOTINYL_LIPOYL

InterPro
IPR000815
Family

Mercuric reductase
PR00945	$\"[136-154]T$ $\"[257-274]T$ $\"[292-309]T$ $\"[312-327]T$ $\"[489-509]T$	HGRDTASE

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[126-148]T$ $\"[158-173]T$ $\"[256-265]T$ $\"[292-317]T$ $\"[377-391]T$ $\"[417-424]T$ $\"[453-474]T$ $\"[518-533]T$ $\"[540-560]T$	PNDRDTASEI

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[260-325]T$	FAD_pyr_redox
PF00070	$\"[292-384]T$	Pyr_redox

InterPro
IPR003016
Binding_site

2-oxo acid dehydrogenase, lipoyl-binding site
PS00189	$\"[27-56]T$	LIPOYL

InterPro
IPR004099
Domain

Pyridine nucleotide-disulphide oxidoreductase dimerisation region
G3DSA:3.30.390.30	$\"[456-581]T$	Pyr_redox_dim
PF02852	$\"[457-566]T$	Pyr_redox_dim

InterPro
IPR006258
Family

Dihydrolipoamide dehydrogenase
TIGR01350	$\"[124-576]T$	lipoamide_DH

InterPro
IPR011053
Domain

Single hybrid motif
SSF51230	$\"[1-98]T$	Hybrid_motif

InterPro
IPR012999
Active_site

Pyridine nucleotide-disulphide oxidoreductase, class I, active site
PS00076	$\"[159-169]T$	PYRIDINE_REDOX_1

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[126-148]T$ $\"[256-265]T$ $\"[292-317]T$ $\"[377-391]T$ $\"[417-424]T$	FADPNR
PF07992	$\"[126-428]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:2.40.50.100	$\"[4-98]T$	G3DSA:2.40.50.100
G3DSA:3.50.50.60	$\"[124-449]T$	G3DSA:3.50.50.60
PTHR22912	$\"[128-574]T$	PTHR22912
PTHR22912:SF20	$\"[128-574]T$	PTHR22912:SF20
SSF51905	$\"[124-418]T$	SSF51905
SSF55424	$\"[453-581]T$	SSF55424

InterPro
IPR004143
Domain

Biotin/lipoate A/B protein ligase
PF03099	$\"[43-127]T$	BPL_LipA_LipB

InterPro
IPR004562
Family

Lipoyltransferase and lipoate-protein ligase
TIGR00545	$\"[1-322]T$	lipoyltrans

InterPro
IPR005107
Domain

CO dehydrogenase flavoprotein, C-terminal
G3DSA:3.30.390.50	$\"[242-329]T$	CO_DH_flav_C

noIPR
unintegrated

unintegrated
G3DSA:3.90.1550.10	$\"[1-241]T$	G3DSA:3.90.1550.10
PTHR12561	$\"[3-293]T$	PTHR12561

","BeTs to 8 clades of COG0095COG name: Lipoate-protein ligase AFunctional Class: HThe phylogenetic pattern of COG0095 is ---kyQvceB----gp--IN-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 10-73 are 53% similar to a (LIGASE LIPOATE-PROTEIN COMPLETE PROTEOME) protein domain (PD016910) which is seen in Q9KF14_BACHD.Residues 240-322 are 43% similar to a (LIGASE LIPOATE-PROTEIN PROTEOME COMPLETE) protein domain (PD016911) which is seen in O07608_BACSU.Residues 107-238 are 45% similar to a (LIGASE COMPLETE PROTEOME LIPOATE-PROTEIN) protein domain (PD106571) which is seen in Q9CJD4_LACLA.Residues 40-225 are 25% similar to a (LIGASE PROTEOME COMPLETE LIPOATE-PROTEIN) protein domain (PD190635) which is seen in Q9Z7T6_CHLPN.Residues 74-238 are 39% similar to a (LIGASE LIPOATE-PROTEIN TRANSFERASE) protein domain (PD004967) which is seen in LPLA_MYCGE.Residues 43-233 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD106577) which is seen in O67765_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 13:55:03 2006","Mon Dec 17 15:29:54 2001","Mon Sep 11 13:55:03 2006","Mon Sep 11 13:55:03 2006","","Mon Dec 17 15:29:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0117 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 17 15:36:23 2001","","No significant hits to the NCBI PDB database.","SMU.131","","Residues 43 to 157 (E-value = 1.7e-29) place SMu0117 in the BPL_LipA_LipB family which is described as Biotin/lipoate A/B protein ligase family (PF03099)","Mon Dec 17 15:29:54 2001","24378649","","","Green DE, Morris TW, Green J, Cronan JE Jr, Guest JR.Purification and properties of the lipoate protein ligase of Escherichia coli.Biochem J. 1995 Aug 1;309 ( Pt 3):853-62.PMID: 7639702Morris TW, Reed KE, Cronan JE Jr.Lipoic acid metabolism in Escherichia coli: the lplA and lipB genes define redundant pathways for ligation of lipoyl groups toapoprotein.J Bacteriol. 1995 Jan;177(1):1-10.PMID: 800260","","Mon Dec 17 15:36:23 2001","1","","","SMU.131","337" "SMu0118","135749","136885","1137","ATGTCAGAAGGAATTTATGAGAAATTGAGGGAAATTCGGCATTATCTTCATCAACATCCTGAAATTTCAGAAAATGAATTTGAAACAACCGCATTCATTAAAAAGCATTTGAAAGATTTGGGCATTGAACCTCTTGATTATCCTTTAAAAACAGGCGTCATTGCAGAAATCGGATCGGGTCAACCCATTATAGCTCTGAGGGCTGATATTGATGCTTTGCCTATTATCGAAAAGACGGGTCTCGCTTATGCTAGCAAGAATGGTGCCATGCACGCTTGCGGCCATGACTTTCATCAAACGAGTTTATTAGGCGCTGCCCAAATTCTCAAAGAAAGAAAGGCAGAAATCAAAGGGACTGTCCGCCTTATCTTTCAGCCGGCTGAAGAAAATTTTCAGGGTGCATACCAAGTGATTGAAGCAGGTGGTATTGAAGGTGTCTCTGCTATTATCGGCTATCATAATAATCCGCATTTAAAACCGGGTCAGATTGGTCTTCGCTCAGGTGCGATCATGGCTGGAGTCGAGCAATTTGAAGTAACTGTGGCTGGTATCAGTGCCCACGCAGCTCGTCCTGATTTAGGAGTAGATACGGTCTTGGCAATCACGACCATGATTCATAATTTGCAGCAGATTGTCTCACGTACGGTTTCGCCATTTGATTCTGCCGTTTTGTCAGTCACCCATATTGATGTTGGTACAACTTGGAATGTCCTGCCAGCCAAAGGATTTTTTGAAGGGACTATTCGGACTTTTGATCCAAAGATTCGTTTAGCTGTTATTAATAAGTTTACCAAAATCGTCGAAACAACAGCAGAACAATTTGGTGCTCAGGTTTCTATTCAGTGGGGAAATTCACCAAAAGTGACTTATAATGATGCTACTTTGACGCCTCTTATTTTTGAAAATTCCAAGACATTTGCTCAGGTCATTGAAACCTTGCCATCAACTGGCGGCGAAGATTTTGCAGCCTATCAGGAAAAAATCCCAGGTGTCTTTGCCTTTGTTGGATCAAATGGTGCTGACAATGCCCCAGACTGGCATCATGATGATTTTATTGTCAAAGATGAAGCCTTACCGACTGCTGTCAATTATTTTGTTGAAAATGCTTTTAAACTACTAGAATATTATAGAAGCTGA","5.60","-10.65","41373","MSEGIYEKLREIRHYLHQHPEISENEFETTAFIKKHLKDLGIEPLDYPLKTGVIAEIGSGQPIIALRADIDALPIIEKTGLAYASKNGAMHACGHDFHQTSLLGAAQILKERKAEIKGTVRLIFQPAEENFQGAYQVIEAGGIEGVSAIIGYHNNPHLKPGQIGLRSGAIMAGVEQFEVTVAGISAHAARPDLGVDTVLAITTMIHNLQQIVSRTVSPFDSAVLSVTHIDVGTTWNVLPAKGFFEGTIRTFDPKIRLAVINKFTKIVETTAEQFGAQVSIQWGNSPKVTYNDATLTPLIFENSKTFAQVIETLPSTGGEDFAAYQEKIPGVFAFVGSNGADNAPDWHHDDFIVKDEALPTAVNYFVENAFKLLEYYRS","136882","No apparent similarities to S.pyogenes or S.pneumoniae.","amino acid amidohydrolase (hippurate amidohydrolase)","Cytoplasm","Similarities in gapped BLAST to amino acid amidohydrolases. Residues 1-377 are 7-374 are 52% similar to the enzyme from Lactococcus (gi|15672938). Residues 7-374 are 48% similar to the hippurate hydrolase from Bacillus subtilis (gi|16079981).No significant similarities to S.pyogenes or S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1523 (2e-54).","

InterPro
IPR002933
Family

Peptidase M20
PF01546	$\"[65-371]T$	Peptidase_M20

InterPro
IPR010168
Family

Peptidase M20D, amidohydrolase
TIGR01891	$\"[9-361]T$	amidohydrolases

InterPro
IPR011650
Domain

Peptidase M20, dimerisation
PF07687	$\"[169-275]T$	M20_dimer

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.10	$\"[1-373]T$	G3DSA:3.40.630.10
SSF53187	$\"[6-374]T$	SSF53187
SSF55031	$\"[173-287]T$	SSF55031

","BeTs to 6 clades of COG1473COG name: Metal-dependent amidohydrolases/aminoacylasesFunctional Class: RThe phylogenetic pattern of COG1473 is ---K--vCEBRh---------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 308-361 are 50% similar to a (HYDROLASE PROTEOME COMPLETE) protein domain (PD004654) which is seen in YXEP_BACSU.Residues 136-252 are 54% similar to a (HYDROLASE ACID PROTEOME COMPLETE) protein domain (PD001757) which is seen in Q9CGY6_LACLA.Residues 153-366 are 23% similar to a (COMPLETE FIXR GENES CDSS) protein domain (PD148485) which is seen in Q44415_AGRTU.Residues 8-133 are 66% similar to a (HYDROLASE PROTEOME COMPLETE ACID) protein domain (PD376484) which is seen in Q9CGY6_LACLA.Residues 177-268 are 32% similar to a (PROTEOME COMPLETE HYDROLASE DEACETYLASE) protein domain (PD293379) which is seen in Y4TI_RHISN.Residues 134-291 are 27% similar to a (AMHX 3.5.1.- AMIDOHYDROLASE AMINOACYLASE) protein domain (PD399183) which is seen in AMHX_BACSU.Residues 254-377 are 37% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD396674) which is seen in Q9CGY6_LACLA.Residues 7-133 are 60% similar to a (HYDROLASE ACID COMPLETE PROTEOME) protein domain (PD002630) which is seen in Q9FDK6_ZYMMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 13:52:46 2002","Thu Apr 25 14:49:04 2002","Tue Oct 29 08:08:58 2002","Thu Apr 25 14:49:04 2002","","Mon Dec 17 15:37:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0118 is paralogously related (blast p-value < 1e-3) to SMu0286, a predicted hippurate hydrolase.","Fri Jan 11 13:52:46 2002","","No significant hits to the NCBI PDB database.","SMU.132","","Residues 6 to 374 (E-value = 6.2e-86) place SMu0118 in the Peptidase_M20 family which is described as Peptidase family M20/M25/M40 (PF01546)","Mon Dec 17 15:37:03 2001","24378650","","","","","","1","","","SMU.132","" "SMu0119","138402","137008","1395","ATGACTAAAAAAATCATGTTAACAATAGCCATGTGTTTAGGGATTTTTATCGTAATGTTAGACACTACTATTATGAACATCACCTTACCGGCTATTCAAAAGGGCTTAGGAGTAAAACTGGATCAACTCTCTTGGACCATCAATGTTTATACCATCATCTTTGCTTCCTGTACCATTCCTTTAAGTAAGATTGCTGATATTTATGGCAAGGGTCGGTTATTTGTCCTTGGTCTGTTGCTCTTTGGAATAGGCAGCTTACTGTCTGGGCTTGCTAATGGATTTTCTCAATTAATTCTTGGACGTATCATCTCCAGTTTTGGAGCCGCTATTTTACTTCCAGTAGGCAACAGTTTAGGGATTTCTTCCTGGGAGGTTAAAGATCGCTTTAAAATTGTTGCTGCTCTTGGTCTCATGCAGGGCGGTGCTGCTGCTATCGGCCCTACTTTGGGCGGTATTCTTACTGATACCTTTTCTTGGCACTGGATTTTCTTTATTAATCTGCCAATCATCATAATCGCAACGTGCCTCATGATTTTATCTTATCATTTTAAAAGTGAGGAAAAGATTGAGTCCAAAATTGATTTTGCTGGCAGCTTTATTTCAATGCTAGGTCTCTTTTTAGTGACATTGGGCTTAATTAAAATAAGAGATTGGGGAGCAGGTGACTGGCGCACTTTAGGCTGTTTGATAACATTTTTGCTTAGTCTCTTTGCCTTTATTATCCTTGAAAAGCACAGTAAGAATCCGATGATTAATTTGAATCTATTTAAGATTAGAGAATTCACAGCTTCAGCATTAGTCGCCTTATTAGCGCAATTTTTCTATATTGGCGTCATCGTGATTTTGCCAACCTTTTTTACAACTATTCAAGGAAAGACAGAACTTGATGCGGCCTTAATTTTACTGCCTATGTCCTTAGTGGTCTTTATCTGCGGTGGTTTAGGAAGTCTGGTTATTAACCAATTGGGCCCAAGATTGCTGGTTTTTGTGGGGCTGACCGCTATTTTACTTTCTTACCTTTTAATCGTCAGCATCAATCCAAATAAAGTGATGGCAATGGCTCTCACAACCTTAATTTTGGGAATTGGTTTTGGTATTATTGCTGGACCTGTCAATGTTTTAGCGGCATCAACTTTACAAGGTGAACTGCTCACCGCCTCTCAAAGCGTTATTGGAGTCGTCAGACAGATTGGCTCTGTTCTAGGCGTCACTGTTTTTATCTCAATGGTTAGCAATAATATGGCAAATTTAAGTCAATATAACCACTCCAGTATGGTAGAAGCTTACATTTCTATCTACAAAATTTGGATCCCTTGCCTACTTATTTTCTTAGTGCTTTCTTTCCTATTTCCAAAGAAAAAACGTTACCTAGAAGGACTAACACAATCAAATTAA","10.00","11.67","50336","MTKKIMLTIAMCLGIFIVMLDTTIMNITLPAIQKGLGVKLDQLSWTINVYTIIFASCTIPLSKIADIYGKGRLFVLGLLLFGIGSLLSGLANGFSQLILGRIISSFGAAILLPVGNSLGISSWEVKDRFKIVAALGLMQGGAAAIGPTLGGILTDTFSWHWIFFINLPIIIIATCLMILSYHFKSEEKIESKIDFAGSFISMLGLFLVTLGLIKIRDWGAGDWRTLGCLITFLLSLFAFIILEKHSKNPMINLNLFKIREFTASALVALLAQFFYIGVIVILPTFFTTIQGKTELDAALILLPMSLVVFICGGLGSLVINQLGPRLLVFVGLTAILLSYLLIVSINPNKVMAMALTTLILGIGFGIIAGPVNVLAASTLQGELLTASQSVIGVVRQIGSVLGVTVFISMVSNNMANLSQYNHSSMVEAYISIYKIWIPCLLIFLVLSFLFPKKKRYLEGLTQSN","137011","No apparent similarities to S.pyogenes or S.pneumoniae.","carbohydrate permease; transmembrane efflux protein","Membrane, Cytoplasm","Several similarities in gapped BLAST to MDR-type permeases. Residues 1-415 are 26% similar to gi|15004812 from C.acetobutylicum. Residues 9-410 are 23% similar to gi|15843349 from M.tuberculosis. No apparent similarities to S.pyogenes or S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1088 (6e-15).","

InterPro
IPR001411
Family

Tetracycline resistance protein TetB
PR01036	$\"[10-34]T$ $\"[70-92]T$ $\"[158-182]T$ $\"[296-320]T$	TCRTETB

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[7-455]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[11-411]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[5-197]T$ $\"[247-458]T$	PTHR10074
PTHR10074:SF57	$\"[5-197]T$ $\"[247-458]T$	PTHR10074:SF57
SSF103473	$\"[1-455]T$	SSF103473

","BeTs to 9 clades of COG0477COG name: PermeasesFunctional Class:� G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 10-67 are 36% similar to a (MEMBRANE EFFLUX INTEGRAL) protein domain (PD337053) which is seen in Q9ZBW5_STRCO.Residues 233-452 are 21% similar to a (BILE ACID CATABOLISM TRANSPORT) protein domain (PD073417) which is seen in BAIG_EUBSP.Residues 194-262 are 42% similar to a (COMPLETE PROTEOME RESISTANCE EFFLUX) protein domain (PD416139) which is seen in O28026_ARCFU.Residues 229-337 are 33% similar to a (COMPLETE PROTEOME TRANSPORTER) protein domain (PD279163) which is seen in Q9CFE0_LACLA.Residues 253-332 are 31% similar to a (TRANSMEMBRANE TRANSPORT TRANSPORTER COMPLETE PROTEOME) protein domain (PD000082) which is seen in Q9RJY0_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:31:14 2002","Mon Dec 17 15:46:19 2001","Mon Dec 17 15:51:08 2001","Mon Dec 17 15:46:19 2001","","Mon Dec 17 15:46:19 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0119 is paralogously related (blast p-value < 1e-3) to SMu1460, SMu1914, SMu0677, SMu1173, SMu0130, SMu1465, and SMu1519, permease-related proteins.","Mon Dec 17 15:53:34 2001","","No significant hits to the NCBI PDB database.","SMU.133c","","No significant hits to the Pfam 11.0 database","Mon Dec 17 15:46:19 2001","24378651","","","","Wed Oct 9 07:31:14 2002","","1","","","SMU.133c","" "SMu0120","138553","139206","654","ATGAGTAATTTTGAAAAAAGGAATAGGAAAATGGCAGAAAAAAATATCAGAAAACCCAAGCAAGAAAGAAGTATTGAAAAGCGCAACAAGATACTTCAAGTTGCTAAAGATTTGTTCTCAGATAAAACTTATTTTAATGTGACAACCAATGAAATTGCTAAAAAAGCTGATGTCTCTGTAGGGACACTCTACGCTTACTTTGCCAGCAAAGAAGATATTTTAACAGCGCTTTTAAAAAGGTATAATGACTTTTTTCTGACAACAATTTTTGCTGATATCAATAGTCAAGATTCTTTAGATAGGTTCAAAAAGAACCCTAAGGAATGGCTGAATGTTTTGATTAATCAGTTATTGGCTGCAGAAGATAAAATTTTTCATGCTCAAATTGAGATGTTAGCCTATGCTATTCCGCAGGCTAAAGCCTTACTGGAGGAGCATAATAATAACTTGAAAAACTTGACCTACAAATGTCTTTTATATTATAGCGATCAGGCTGCCAATCCAAGCTTTAAAACCTTGTCTCTTGTGGTCTTTGATTTTATTTCAGCTTTGGTAGATGAATTGCTTTATCATGAGCACACGCAAGAAGAAGCACACCAAATAAAAAAGACTGGCATAGACAGTCTTGATCTGATTATTAAGTCTTATTTATAG","9.00","3.16","25222","MSNFEKRNRKMAEKNIRKPKQERSIEKRNKILQVAKDLFSDKTYFNVTTNEIAKKADVSVGTLYAYFASKEDILTALLKRYNDFFLTTIFADINSQDSLDRFKKNPKEWLNVLINQLLAAEDKIFHAQIEMLAYAIPQAKALLEEHNNNLKNLTYKCLLYYSDQAANPSFKTLSLVVFDFISALVDELLYHEHTQEEAHQIKKTGIDSLDLIIKSYL","139203","","transcriptional regulator, TetR/AcrR family","Cytoplasm","Generally weak matches in gapped BLAST to transcriptional regulators of the TetR/AcrR family. Residues 13-134 are 34% similar to gi|15893317 from C.acetobutylicum. Residues 17-82 are 42% similar to residues 6-71 of a predicted regulator from S.solfataricus (gi|15899244).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0258 (2e-05).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[31-44]T$ $\"[52-75]T$	HTHTETR
PF00440	$\"[31-77]T$	TetR_N
PS50977	$\"[25-85]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[16-96]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[9-77]T$	Homeodomain-rel

","BeTs to 8 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 1.2e-11. IPB001647 43-73","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 07:32:20 2002","Tue Oct 8 08:08:00 2002","Mon Dec 17 15:58:13 2001","Tue Oct 8 08:08:00 2002","Mon Dec 17 15:54:37 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0120 is paralogously related (blast p-value < 1e-3) to SMu0539, SMu0214, SMu1243, and SMu1139, probable transcriptional regulators.","Mon Dec 17 15:59:31 2001","","No significant hits to the NCBI PDB database.","SMU.134","","Residues 31 to 77 (E-value = 6.8e-17) place SMu0120 in the TetR_N family which is described as Bacterial regulatory proteins, tetR family (PF00440)","Mon Dec 17 15:54:37 2001","24378652","","","","","","1","","","SMU.134","" "SMu0121","140364","139471","894","ATGAATATTAAAGATTTAAAGTATTTTTATCACCTGTCACAATTACAGTCCTTCACTAAGGTTGCTGAAAAATTTCAAATTAGCCAGCCTTCTGTTTCCTATTCTGTCAAAAGATTAGAGGAACAATTTAATTGTGACCTTATTGTTAAGGATCCCTCTCATCGTACTTTTGCTTTGACGCAACAAGGAAATATTTTGAAGCGTCACCTTGAGAGAATTCTGCCGGAAATTAGTTCTGCCCAAAAGGAGATGAACCGTTCACTGGCTCACTATTCTACCTTAGGATGCCCACCCATTATTATTAATTATTTACTGTCGCTGCTTAAAGAAACCAATCAAGACTTAGCTTTTCTGAAACGTATTCGTTCCATTCGAGGAGGTTCTGTTGAGTTATTGGAGCAACTATTACAGGGGGATCTGGATCTCAGTTTAATTGGCACAATAGAACCTTTTTACCATGATGAATTAGTTATCAAAAAAATTCTTCATCGGAAACTCTATCTGATTGTTTCTAAAGATCATTTATTGGCTAAAAGAAAAAAAGCCATCGCTTTTGCTGATGTCTTAAAGGAAAATTTTATTCTTTTAGATGAACACAATATCCATCTAAAGGCCTTTGATTATCTTAATCAAACCCATCAAAATCAGGCTCAGATTTTTTTCAAATCTGATGATGTTACTCTTATCAAGCAAATGGTCAGCCACAATATGGGTGTCAGTTTGTTAACAGATATCTCACTAACCAAACAGGATCATCATCTGGTCAAAATTCCTTTTAAAGAAAATAATAAATTAGGATTTTATGTTAACTACGCTTACTTAAAATCCTCAACCTTAACACCTGATATCAGGCATTTAGTTGATCTGCTGGATAAAATCGCTCAATCATTTTAA","9.80","9.28","34415","MNIKDLKYFYHLSQLQSFTKVAEKFQISQPSVSYSVKRLEEQFNCDLIVKDPSHRTFALTQQGNILKRHLERILPEISSAQKEMNRSLAHYSTLGCPPIIINYLLSLLKETNQDLAFLKRIRSIRGGSVELLEQLLQGDLDLSLIGTIEPFYHDELVIKKILHRKLYLIVSKDHLLAKRKKAIAFADVLKENFILLDEHNIHLKAFDYLNQTHQNQAQIFFKSDDVTLIKQMVSHNMGVSLLTDISLTKQDHHLVKIPFKENNKLGFYVNYAYLKSSTLTPDIRHLVDLLDKIAQSF","139474","For other 'mle' genes see SMu0123 (mleS) and SMu0124 (mleP).","transcriptional regulator, MleR-related / LysR-related","Cytoplasm","Similarities in gapped BLAST to malolactic regulatory proteins. Residues 1-290 are 40% similar to the transcriptional regulatoractivator from Lactococcus lactis subsp. lactis (gi|15672854) and are 30% similar to the regulator from Oenococcus oeni (gi|5870595).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0691 (1e-08).","

InterPro
IPR000847
Domain

Bacterial regulatory protein, LysR
PR00039	$\"[18-29]T$ $\"[29-39]T$ $\"[39-50]T$	HTHLYSR
PF00126	$\"[3-64]T$	HTH_1
PS50931	$\"[1-58]T$	HTH_LYSR

InterPro
IPR005119
Domain

LysR, substrate-binding
PF03466	$\"[85-295]T$	LysR_substrate

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-89]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[165-252]T$	G3DSA:3.40.190.10
SSF46785	$\"[1-104]T$	SSF46785
SSF53850	$\"[86-295]T$	SSF53850

","BeTs to 5 clades of COG0583COG name: Transcriptional regulators, LysR familyFunctional Class: KThe phylogenetic pattern of COG0583 is aMt--Q-CEBRH---------Number of proteins in this genome belonging to this COG is 5","***** IPB000847 (Bacterial regulatory protein, LysR family) with a combined E-value of 4.4e-09. IPB000847 17-50***** IPB001583 (NodD transcription activator carboxyl terminal region) with a combined E-value of 3.9e-06. IPB001583A 5-55","Residues 84-276 are 38% similar to a (ACTIVATOR REGULATION MALOLACTIC) protein domain (PD202505) which is seen in MLER_LACLA.Residues 3-85 are 32% similar to a (DNA-BINDING REGULATION TRANSCRIPTION TRANSCRIPTIONAL) protein domain (PD254092) which is seen in Q9I261_PSEAE.Residues 1-77 are 49% similar to a (TRANSCRIPTIONAL DNA-BINDING REGULATION REGULATOR) protein domain (PD000161) which is seen in MLER_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:03:23 2002","Tue Oct 8 08:09:27 2002","Wed Dec 19 14:12:01 2001","Thu Apr 4 14:58:21 2002","Wed Dec 19 10:51:06 2001","Wed Dec 19 10:51:06 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0121 is paralogously related (blast p-value < 1e-3) to SMu1870, SMu0844, SMu0776, and SMu0168, all predicted transcriptional regulators.","Wed Dec 19 14:20:19 2001","","No significant hits to the NCBI PDB database.","SMU.135c","","Residues 3 to 64 (E-value = 7.5e-14) place SMu0121 in the HTH_1 family which is described as Bacterial regulatory helix-turn-helix protein, lysR family (PF00126)Residues 85 to 295 (E-value = 2e-17) place SMu0121 in the LysR_substrate family which is described as LysR substrate binding domain (PF03466)","Wed Dec 19 10:51:06 2001","","","","Labarre,C., Guzzo,J., Cavin,J.F. and Divies,C.Cloning and characterization of the genes encoding the malolacticenzyme and the malate permease of Leuconostoc oenosAppl. Environ. Microbiol. 62 (4), 1274-1282 (1996)PubMed: 8919788Labarre,C., Divies,C. and Guzzo,J.Genetic organization of the mle locus and identification of amleR-like gene from Leuconostoc oenosAppl. Environ. Microbiol. 62 (12), 4493-4498 (1996)PubMed: 8953720","","Thu Apr 4 14:58:21 2002","1","","","SMU.135c","" "SMu0122","140907","140554","354","ATGAAGAAAAAAAGCTATCTCCAAAAATATGTTGCAAATAAAGTAAGGTATCATCGGCAAGCACAAGGCATCAGCCAAGAAAGTTTGTCTGAAAAAGCTGGATTAGGATTGAAATATATCAATCAGATTGAAAATCAAAACCATAATCTCAGCTTGCAGACGCTTGAAAAAGTGATTGAAGCACTAGGTATGACACCGGAAGATTTTTTTGACTTTAACAGTCTTGAAGGAACAATCAATTTCGAGAAACAATTAACTTTAAAACGCCTTAATATGAAAATAAAGCAACTTCCCAAGAGAAAACAACAAACCTTCATTGCTATTTTTGAAGAGATTATTGATAATCTTGATTAA","10.10","4.47","13688","MKKKSYLQKYVANKVRYHRQAQGISQESLSEKAGLGLKYINQIENQNHNLSLQTLEKVIEALGMTPEDFFDFNSLEGTINFEKQLTLKRLNMKIKQLPKRKQQTFIAIFEEIIDNLD","140557","","conserved hypothetical protein; probable transcriptional regulator","Cytoplasm","Weak similarities in gapped BLAST to conserved hypothetical protiens and to transcriptional regulators. Residues 11-70 are 38% similar to gi|15924088 from S.aureus. Residues 12-75 are 34% similar to a regulatory element from S. paratyphi (gi|11992069).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0251 (7e-04).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[15-69]T$	HTH_3
SM00530	$\"[14-69]T$	HTH_XRE
PS50943	$\"[15-69]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[11-70]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[11-73]T$	G3DSA:1.10.260.40

","BeTs to 4 clades of COG1396COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1396 is --T--qV-EBR---------xNumber of proteins in this genome belonging to this COG is 6","No significant hits to the Blocks database.","Residues 12-66 are 38% similar to a (COMPLETE PROTEOME REGULATOR) protein domain (PD284760) which is seen in Q9EZ27_SALPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:06:10 2002","Tue Apr 1 11:27:51 2003","Tue Apr 1 11:27:51 2003","Tue Oct 8 08:08:25 2002","","Wed Dec 19 14:12:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0122 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 14:17:02 2001","","No significant hits to the NCBI PDB database.","SMU.136c","","Residues 15 to 69 (E-value = 5.9e-12) place SMu0122 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Wed Dec 19 14:12:47 2001","24378654","","","","","","1","","","SMU.136c","" "SMu0123","141022","142644","1623","ATGTATGCACATGACATTTTAAACGATCCTTTTTTGAATAAAGGGACTGCTTTTACCATGGAAGAACGTAAGAAATTTGGACTTATTGGTCTTTTGCCCCCTCACATTCAGACTCTTAAAGAGCAAGCAGAGCAGACGTATGCGCAAATGCAAACTAAAGCTAATAACTTGGAAAAACGTCTTTTCTTGATGGAGATTTTTAATACCAACCGGACACTTTTCTACTATCTCTTTTCTCAACATTTGGAAGAGTTAAATCCAATTGTTTACGATCCAACCATCGCAGATACGATTGAAGGTTACAGTGATCTTTTTGTGGATCCTCAATATGCGGGTTATTTGGACATTAACCATCCTGAAAATATTGAGGCTACCCTCAAAAATGCGGCAGGTGACCGTGATATTCGTTTGATTGTTGTGACCGATGCCGAAGGTATCCTTGGTATCGGTGACTGGGGGACTAATGGGGTGGACATCTCTGTTGGGAAGCTCATGGTTTACACAGGGGCAGCAGGGATTGATCCAGTAACTGTTTTGCCATTGGTGATTGATGCAGGTACCAACCGTGAGGAATTGCGCAATAATCCTAACTATCTGGGGAACCGTCATGAACGTGTTCGTGGTGAGCGTTACTATGACTTCGTGGATCAATTTGTCCAAACAGCTGAACGTCTTTTCCCTAAACTTTACCTTCACTGGGAAGACTTCGGTCGTTCAAATGCGGCCAATATCTTGGAAAAATACCGTAAGGAAATTCCAACCTTCAACGATGATATTCAAGGGACTGGCATCGTAACCCTTGGTGGTATCTTTGCGGCTATGGATATCACAGGTGAAAAATTGACTGATCAAGTCTATCTCTGTTACGGTGGCGGTACAGCAGGTGCGGGTATTGCCTCTCGTGTCTTGCGTGAAATGGTTTCAGAAGGCCTGCCTGAAGACGAAGCCTACAAGCGTTTCTTCATGGTGGACAAGCAAGGTCTCCTCTTTGACGATATGGACGACTTGACTCCTGAACAAAAGCCATTTGCCAAGAAGCGGGCGGATTTTCCAAATGCAGATCAGTTGACAGACCTCTTGCAAGTGGTTAAAACCGTGAAACCAACCATCTTGGTTGGTACCTCAACAAATCCAGGTGCCTTCACGAAAGAAGTTGTTGAAGCTATGTGTGAAAACACTGAACGCCCAGTCATCTTCCCAATCTCTAATCCTACAAAATTGGCAGAAGCATCGGCTCAAGACTTGATTACCTGGTCTGATGGTAAGGCTTTTGTGGCAACCGGTATTCCAGCTGATACTGTATCGTACAAGGGTGTGGACTATGTCATCGGTCAAGCTAACAATGCCCTCATCTACCCTGGCCTTGGGCTTGGGATGTTGGCATCAGAAGCTAGCCTTTTGACAGATGAAATGATCGGAGCGGCAGCACACTCTCTCAGTGGTATCATCGATATCACCAAACCAGGTGCGCCAGTTCTTCCTCCATTCAAATATGTGGGTGATGTGTCTATCAAGGTCGCTGAAGCCGTGGCTAAGAAGGCTCAAGAACAAGGTCTTGCACGTGCTGAAGAAACCGATATGGCTAAAGCTGTTCGTGACTTTAAGTGGTACCCAGAGTATTAA","4.60","-24.35","59723","MYAHDILNDPFLNKGTAFTMEERKKFGLIGLLPPHIQTLKEQAEQTYAQMQTKANNLEKRLFLMEIFNTNRTLFYYLFSQHLEELNPIVYDPTIADTIEGYSDLFVDPQYAGYLDINHPENIEATLKNAAGDRDIRLIVVTDAEGILGIGDWGTNGVDISVGKLMVYTGAAGIDPVTVLPLVIDAGTNREELRNNPNYLGNRHERVRGERYYDFVDQFVQTAERLFPKLYLHWEDFGRSNAANILEKYRKEIPTFNDDIQGTGIVTLGGIFAAMDITGEKLTDQVYLCYGGGTAGAGIASRVLREMVSEGLPEDEAYKRFFMVDKQGLLFDDMDDLTPEQKPFAKKRADFPNADQLTDLLQVVKTVKPTILVGTSTNPGAFTKEVVEAMCENTERPVIFPISNPTKLAEASAQDLITWSDGKAFVATGIPADTVSYKGVDYVIGQANNALIYPGLGLGMLASEASLLTDEMIGAAAHSLSGIIDITKPGAPVLPPFKYVGDVSIKVAEAVAKKAQEQGLARAEETDMAKAVRDFKWYPEY","142641","For other 'mle' genes see SMu0121 (mleR) and SMu0124 (mleP).","malolactic enzyme","Cytoplasm","Strong matches in gapped BLAST to predicted malolactic enzymes. Residues 1-539 are 77% similar to the enzyme from Lactococcus lactis (gi|628948). Residues 6-539 are 65% similar to gi|2497789 from Leuconostoc oenos.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1919 (2e-17).","

InterPro
IPR001891
Family

Malic oxidoreductase
PR00072	$\"[73-97]T$ $\"[135-164]T$ $\"[171-193]T$ $\"[230-248]T$ $\"[255-271]T$ $\"[286-302]T$ $\"[393-409]T$	MALOXRDTASE
PIRSF000106	$\"[1-540]T$	ME
PS00331	$\"[255-271]T$	MALIC_ENZYMES

InterPro
IPR012301
Domain

Malic enzyme, N-terminal
PF00390	$\"[67-257]T$	malic

InterPro
IPR012302
Domain

Malic enzyme, NAD-binding
PF03949	$\"[259-515]T$	Malic_M

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[259-536]T$	G3DSA:3.40.50.720
PTHR23406	$\"[31-540]T$	PTHR23406
PTHR23406:SF2	$\"[31-540]T$	PTHR23406:SF2
SSF51735	$\"[259-540]T$	SSF51735
SSF53223	$\"[4-258]T$	SSF53223

","BeTs to 9 clades of COG0281COG name: Malic enzymeFunctional Class: CThe phylogenetic pattern of COG0281 is a--ky-vcEBrh--------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001891 (Malic enzymes) with a combined E-value of 2.3e-198. IPB001891A 6-34 IPB001891B 66-110 IPB001891C 138-173 IPB001891D 175-227 IPB001891E 233-283 IPB001891F 290-299 IPB001891G 318-329 IPB001891H 359-389 IPB001891I 394-434 IPB001891J 437-471 IPB001891K 490-520","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:10:17 2002","Wed Dec 19 14:21:29 2001","Wed Dec 19 14:28:44 2001","Thu Apr 4 14:59:15 2002","Wed Dec 19 14:21:29 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0123 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 14:21:29 2001","Wed Dec 19 14:21:29 2001","pdb|1DO8|A Chain A, Crystal Structure Of A Closed Form Of Human... 292 6e-080pdb|1EFK|A Chain A, Structure Of Human Malic Enzyme In Complex ... 292 6e-080pdb|1QR6|A Chain A, Human Mitochondrial Nad(P)-Dependent Malic ... 292 6e-080","SMU.137","","Residues 68 to 257 (E-value = 7.4e-97) place SMu0123 in the malic family which is described as Malic enzyme, N-terminal domain (PF00390)Residues 259 to 515 (E-value = 1.2e-117) place SMu0123 in the Malic_M family which is described as Malic enzyme, NAD binding domain (PF03949)","Wed Dec 19 14:21:29 2001","24378655","","","Ansanay,V., Dequin,S., Blondin,B. and Barre,P.Cloning, sequence and expression of the gene encoding themalolactic enzyme from Lactococcus lactisFEBS Lett. 332 (1-2), 74-80 (1993)PubMed: 8405453 Denayrolles,M., Aigle,M. and Lonvaud-Funel,A.Cloning and sequence analysis of the gene encoding Lactococcuslactis malolactic enzyme: relationships with malic enzymesFEMS Microbiol. Lett. 116 (1), 79-86 (1994)PubMed: 8132158Labarre,C., Guzzo,J., Cavin,J.F. and Divies,C.Cloning and characterization of the genes encoding the malolacticenzyme and the malate permease of Leuconostoc oenosAppl. Environ. Microbiol. 62 (4), 1274-1282 (1996)PubMed: 8919788","","Thu Apr 4 14:59:15 2002","1","","","SMU.137","" "SMu0124","142800","143744","945","ATGGATATCTTTTTAACCTCAATTTCGAGTATTATTCCCATCATTGTGATTATTGTACTCGGTTATGCCCTTCAGGTGCGTGGTTGGTTTACAGATAATTTTGGCCCCACACTCTCTCACCTTATCATGAATGTGGCGCTGCCAGTGTCCATTTTTGTGTCGGTCCTTAAGTACTTGACTCTGGATAAGCTAGTTAGTCTGTCAGGTGGTCTGCTCTACACCTTTGGTGCCTTTATTCTAACCTATATTTTAGCCTTCCTAGCTGTAAAGATTTTTAAGGTCCGTCCAGGTCGCAGAGGGACCATGATCAATACCTTTGTCAATGCCAACACTATTTTCATCGGTCTGCCCTTGAATGTAGCACTCTTTGGCGATCGGGCTCTGCCTTACTTCCTAATTTACTATATTACCAATACCATCTCAACTTGGACTCTAGGTGTCTACCTCATGACGACGGATAGCAAGTCTGGTAAAGGAAAAGCGACCAAGTTTAATTGGAAAAACCTTTTGCCAGCTCCCCTCATTGGTTTCTTGGTAGCCTTGGTCTTCTTGATTCTGCGCATTCCGGTGCCGGACTTTGCGACTAGCACGTTGACCTATATTGGTAATATCGTGACACCTCTGTCTTTGATTTATATCGGTATTGTTTTGGCTAAGGCTGGGCTTAAGAGTATCCACTTTGACCAAGATACTATTGTGACTCTGGTGGGACGCTTTATCTTAGCCCCTATCGTTATGTTTGGTCTTCTTTATTTGACAGGAAAAGGTCTGCCAGTGACTGAGTTTAAGACTTTTGTGGTTCAATCAGCAGCTCCGGCACTTGCGGTCTTGCCAATTCTTGCCAGCCAAGGTGATGGTGATGTCGAATTTTCAACTAATGTCGTTACCCTGAGTACAGTACTCTTTGTAATTGTCATTCCGATTGTTGTGACCTTGATGGGTTAA","10.50","8.46","34135","MDIFLTSISSIIPIIVIIVLGYALQVRGWFTDNFGPTLSHLIMNVALPVSIFVSVLKYLTLDKLVSLSGGLLYTFGAFILTYILAFLAVKIFKVRPGRRGTMINTFVNANTIFIGLPLNVALFGDRALPYFLIYYITNTISTWTLGVYLMTTDSKSGKGKATKFNWKNLLPAPLIGFLVALVFLILRIPVPDFATSTLTYIGNIVTPLSLIYIGIVLAKAGLKSIHFDQDTIVTLVGRFILAPIVMFGLLYLTGKGLPVTEFKTFVVQSAAPALAVLPILASQGDGDVEFSTNVVTLSTVLFVIVIPIVVTLMG","143741","For other 'mle' genes see SMu0121 (mleR) and SMu0123 (mleS).","malate permease/auxin efflux carrier","Membrane, Cytoplasm","Similarities in gapped BLAST to malate permeases. Residues 1-310 are 54% similar to the enzyme from Oenococcus oeni (gi5870596). Residues 20-291 are 34% similar to gi7363467 from Clostridium cellulovorans.SMu0124 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004776
Family

Auxin efflux carrier
PF03547	$\"[6-310]T$	Mem_trans

","BeTs to 6 clades of COG0679COG name: Predicted permeasesFunctional Class: RThe phylogenetic pattern of COG0679 is -mt-YqVceb----------xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 35-313 are 24% similar to a (PROTEOME COMPLETE PA0188 BH2670) protein domain (PD333104) which is seen in Q9WYQ5_THEMA.Residues 20-308 are 56% similar to a (AUXIN TRANSPORT COMPLETE PROTEOME) protein domain (PD014028) which is seen in Q48797_OENOE.Residues 83-308 are 26% similar to a (PROTEOME COMPLETE TRANSMEMBRANE INTEGRAL) protein domain (PD214616) which is seen in YA31_METJA.Residues 22-149 are 29% similar to a (PROTEOME COMPLETE) protein domain (PD321077) which is seen in O67397_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 20 12:44:51 2007","Tue Feb 20 12:44:51 2007","Tue Feb 20 12:44:51 2007","Thu Apr 4 14:59:59 2002","","Wed Dec 19 14:38:02 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0124 is paralogously related (blast p-value < 1e-3) to SMu0826, a possible permease.","Wed Dec 19 14:38:54 2001","","No significant hits to the NCBI PDB database.","SMU.138","","Residues 6 to 310 (E-value = 1.5e-62) place SMu0124 in the Auxin_eff family which is described as Auxin Efflux Carrier (PF03547)","Wed Dec 19 14:38:02 2001","24378656","","","Tamaru,Y. and Doi,R.H.The engL gene cluster of Clostridium cellulovorans contains a genefor cellulosomal manAJ. Bacteriol. 182 (1), 244-247 (2000)PubMed: 10613891Labarre,C., Guzzo,J., Cavin,J.F. and Divies,C.Cloning and characterization of the genes encoding the malolacticenzyme and the malate permease of Leuconostoc oenosAppl. Environ. Microbiol. 62 (4), 1274-1282 (1996)PubMed: 8919788","","Thu Apr 4 14:59:59 2002","1","","","SMU.138","" "SMu0125","143865","145049","1185","ATGACAACACCCAACACCCCACAGCCGCAAAGAAAAAGCGACGGAAAAGGTTGGCTTGATTTTGGACCGCGTAACTTGAGCCGCGATAATGAAAATCCGGATATCTTGGTTCCGCCTGTCACTGACCATGGGACCATGCCCAATATGCGCTACAGCTTTTCAGATGCCCACAATCGGATGGAAGAAGGAGGCTGGGCGCGTGAAGTGACCATTCGTGAACTGCCTGCTTCAGATGAATTGGCTGGTGTCAATATGGCCTTGGCACCAGGTGCTTATCGTGAACTGCATTGGCACAAAGAAGCCGAATGGGGACTTATGCTGTACGGCAATGCCCGCATTACAGCGATTGACGAGAACGGTCAGTCTTATATTGATGATGTCGAAGAAGGAGATCTTTGGAATTTTGAATCCGGCGTTGCTCATTCTATTCAGGCCTTGGATAAGGGCTGTGAGTTTCTGTTAGTTTTCAGCGAAGCCAATTTCTCAGAGAATCAAACCTTACTGCTTAGTGACTGGTTGGCTCACACTCCTGATGACATCGTTGCTGCTAATTTTAAAAAGACCGAGGAAGAATTGGCTAGTCTTCCTAAGACAGAAAAATATATCTTTAATGGGACTATTCCTGGTTCTATTGAAGCAGAGAAGCGCACCAATCCCAATGGTGATGTGGTCAATCCGCTGACACTGCATTTGGATAAAATTGCACCGATTCAGTCAGAAGCTGGACGTGCTTGGATTTTGGATCAGAAGGTCTTTCCGGCTGCTAAGACGATTTCAGCAGCTATTGTTGAGGTTGAGCCGGGCGGTATGCGGGAATTGCACTGGCATCCTAAGTCATCCGAATGGCAGTATTACATCAAGGGTCAGGCCCGCATGACAGTTTTTAATTCTAATGGTTTGGCTCGTACCTATGACTTTTCAGCTGGAGATGTAGGCTATGTACCCAATGTAGCGGGGCATTATGTTCAAAATACGGGTGACGAAACGTTGGTCTTCGTTGAAGTTTTTCGTAACCCTGATTATTCCGATATTTCGCTCAATAAGTGGCTGGCGACAACTCCTGTCAATAATGTTGCAGAGCACCTCAATCTTCCTAAGGAACTTGTCCAAAATCTTCCTCAGGCAGAGACTCCGCAACCTGTCATTTGGTTTGATAAGGATAAGGCTGCAAAAAAGCCTTTTTAG","4.70","-19.36","44091","MTTPNTPQPQRKSDGKGWLDFGPRNLSRDNENPDILVPPVTDHGTMPNMRYSFSDAHNRMEEGGWAREVTIRELPASDELAGVNMALAPGAYRELHWHKEAEWGLMLYGNARITAIDENGQSYIDDVEEGDLWNFESGVAHSIQALDKGCEFLLVFSEANFSENQTLLLSDWLAHTPDDIVAANFKKTEEELASLPKTEKYIFNGTIPGSIEAEKRTNPNGDVVNPLTLHLDKIAPIQSEAGRAWILDQKVFPAAKTISAAIVEVEPGGMRELHWHPKSSEWQYYIKGQARMTVFNSNGLARTYDFSAGDVGYVPNVAGHYVQNTGDETLVFVEVFRNPDYSDISLNKWLATTPVNNVAEHLNLPKELVQNLPQAETPQPVIWFDKDKAAKKPF","145046","","oxalate decarboxylase","Cytoplasm, Periplasm, Extracellular","Similarities in gapped BLAST to conserved hypotheticals. Residues 7-378 are 58% similar to yvrK from Bacillus subtilis (gi16080377). Residues 5-373 are 43% similar to gi15890222 from Agrobacterium tumefaciens.SMu0125 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006045
Domain

Cupin 1
PF00190	$\"[51-193]T$ $\"[229-370]T$	Cupin_1

InterPro
IPR011051
Domain

Cupin, RmlC-type
SSF51182	$\"[9-373]T$	RmlC_like_cupin

InterPro
IPR014710
Domain

RmlC-like jelly roll fold
G3DSA:2.60.120.10	$\"[2-209]T$ $\"[222-376]T$	RmlC-like_jellyroll

","BeTs to 3 clades of COG2140COG name: Thermophilic glucose-6-phosphate isomerase and related metalloenzymesFunctional Class: RThe phylogenetic pattern of COG2140 is a--k---c-B-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 262-333 are 70% similar to a (GERMIN-LIKE PROTEOME COMPLETE PRECURSOR) protein domain (PD000728) which is seen in O34767_BACSU.Residues 253-323 are 36% similar to a (PROTEOME LYASE COMPLETE YOAN) protein domain (PD414028) which is seen in O34767_BACSU.Residues 156-261 are 28% similar to a (LYASE DECARBOXYLASE OXALATE) protein domain (PD253291) which is seen in Q9UVK4_FLAVE.Residues 156-239 are 48% similar to a (PROTEOME COMPLETE YVRK YOAN) protein domain (PD023917) which is seen in O34714_BACSU.Residues 5-66 are 59% similar to a (PROTEOME COMPLETE LYASE YVRK) protein domain (PD156271) which is seen in O34767_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 8 18:02:34 2005","Tue Feb 8 18:02:34 2005","Tue Feb 8 18:02:34 2005","Tue Feb 8 18:20:41 2005","","Wed Dec 19 14:40:23 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0125 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 14:43:25 2001","","No significant hits to the NCBI PDB database.","SMU.139","","Residues 51 to 193 (E-value = 1.4e-12) place SMu0125 in the Cupin family which is described as Cupin (PF00190)Residues 229 to 370 (E-value = 1.6e-15) place SMu0125 in the Cupin family which is described as Cupin (PF00190)","Tue Feb 8 18:02:34 2005","24378657","","","","","","1","","","SMU.139","" "SMu0126","145133","146428","1296","GTGACTCTAGCCTGCAACTTGGCCGCAGCCGGCAAAAAGACAGCGCTCATTGAGGCTAGAGATTGGGGAGGGACAACTGTCAATCGCGGCTCTACCCCTAAGAAGGCTCTTTTAGCACTAGCTGAATTGCATCATCATCAGGAGAGCTTTCTGCATAGAGGTCTGGAGACAGTCTCTCACGTCAAGTGGGAAGATGCTCTGCTGACGCGGGATTGGTTGGTTTCAGATGAGTCAGCCAGAGCGAAGGAGAGAGCTATCAAAGCAGGTGTAGAGACTTATGAAGCCTATGCTTTCTTTGAAGATGCTCACCATCTAAAGGTAAACGGTCAGGTGCTGAGCACTGCAACTATTGTTTTAGCGACGGGCTCTGTGCCTCGAAAGATTGATATAGAAGGGGCTTCTTACATTGATAGTAGCGCTAATCTTATGCGGCTCCATCAGCAGCCCAAGGTAATTGCCTTGATTGGTGCCGGTGTGATTGCCATGTCGCTGATTTCAAGCTTTACTGAGCTGGGAACAAAAGTCCATGTCATTCAGCACAATGATCGTGTTCTGGGTAATTTTGACTCAGAACTTGTAGATATTCTGGTCAATCGTTTGAAAAGTCGCGGTGCAGAATTTCATATGGAAGCAGAAGCAGAGCGTGTTGAAAGAAGTACTTCAGGCTATCAGGTAACCTTGACGAATGGGGAAATAGTTATTGTTGACGGTATTTATGATGTTGCCGGTCGAATTGCCAATATCGGCGGTCTCCAATTGGAAAAAGCCGGCATAGAATATACCGAGCGCGGAATCTCTGTTGATGATCATCTGACGACATCTCAGCCTCACATTTTTGCTATGGGAGATTGCTGTGATGCACCGGTGCCTAAGCTGAATTCCTATGCGGATTTTCAGGCTAAATATCTGAGTCAGCTCTTAAATGATGAATCAAAAGAAGCTATCCAGTATCCGATAGCGCCGGCGGCAACTGTCTACAGTATTCCCAAAATCGGTCAGGTTGGTGTCAGTGTTAATCAAGCACGGCAGCATCCGCAGGACTATGACGTGACACAGCTAAACATGTCTAATTGGCAGAATTACAAACGCGTTCACGATGATTTGGCTGTCATCAAACTAGTTGTGTCCAAATCAGATCAGCATGTTGCAGGAGCAGAAATCGTCAGTGACACGGCAGATATTCTAGTCAATTATCTAGCTATTTTGCTCAATCGCAGAGTGAGTTTTCAGGAGTTGCAGGATATCATCTTTGCTTATCCGTCACTGGCGACAGATTTATATGGTTTGTGGAAATAA","6.00","-9.26","47387","MTLACNLAAAGKKTALIEARDWGGTTVNRGSTPKKALLALAELHHHQESFLHRGLETVSHVKWEDALLTRDWLVSDESARAKERAIKAGVETYEAYAFFEDAHHLKVNGQVLSTATIVLATGSVPRKIDIEGASYIDSSANLMRLHQQPKVIALIGAGVIAMSLISSFTELGTKVHVIQHNDRVLGNFDSELVDILVNRLKSRGAEFHMEAEAERVERSTSGYQVTLTNGEIVIVDGIYDVAGRIANIGGLQLEKAGIEYTERGISVDDHLTTSQPHIFAMGDCCDAPVPKLNSYADFQAKYLSQLLNDESKEAIQYPIAPAATVYSIPKIGQVGVSVNQARQHPQDYDVTQLNMSNWQNYKRVHDDLAVIKLVVSKSDQHVAGAEIVSDTADILVNYLAILLNRRVSFQELQDIIFAYPSLATDLYGLWK","146425","","glutathione reductase","Cytoplasm","Similarities in gapped BLAST to glutathione reductase proteins. Residues 2-429 are 32% similar to the predicted enzyme from Listeria innocua (gi|16800540). Residues 4-431 are 29% similar to gi|2791905 from Staphylococcus sciuri.For a previously sequenced gor protein, see SMu0762.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0112 (2e-32).","

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[22-37]T$ $\"[117-126]T$ $\"[151-176]T$ $\"[236-250]T$ $\"[278-285]T$ $\"[317-338]T$ $\"[382-397]T$ $\"[404-424]T$	PNDRDTASEI

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[121-191]T$	Q8DWC4_STRMU_Q8DWC4;
PF00070	$\"[151-238]T$	Pyr_redox

InterPro
IPR004099
Domain

Pyridine nucleotide-disulphide oxidoreductase dimerisation region
G3DSA:3.30.390.30	$\"[324-426]T$	no description
PF02852	$\"[321-427]T$	Pyr_redox_dim

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[117-126]T$ $\"[151-176]T$ $\"[278-285]T$	FADPNR
PF07992	$\"[7-289]T$	Pyr_redox_2

InterPro
IPR015723
Family

Glutathione reductase
PTHR22912:SF13	$\"[2-429]T$	GLUTATHIONE REDUCTASE

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[1-318]T$	no description
PTHR22912	$\"[2-429]T$	DISULFIDE OXIDOREDUCTASE

","BeTs to 11 clades of COG1249COG name: Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymesFunctional Class:� CThe phylogenetic pattern of COG1249 is amt-YqvCEBRH--gp--inXNumber of proteins in this genome belonging to this COG is 4","***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 3.4e-11. PR00368B 117-126 PR00368C 151-176 PR00368D 236-250 PR00368E 278-285","Residues 4-420 are 29% similar to a (OXIDOREDUCTASE FLAVOPROTEIN FAD CENTER REDOX-ACTIVE) protein domain (PD000139) which is seen in O54274_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 14:10:03 2002","Wed Dec 19 14:44:46 2001","Sun Oct 27 20:19:12 2002","Wed Dec 19 14:44:46 2001","Wed Dec 19 14:44:46 2001","Wed Dec 19 14:44:46 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0126 is paralogously related (blast p-value < 1e-3) to SMu0762, also a predicted glutathione reductase, SMu1299, a predicted dihydrolipoamide dehydrogenase, SMu0116, a predicted dihydrolipoamide dehydrogenase, and to SMu1020 and SMu0693, predicted NADH oxidases.","Fri Jan 11 14:10:03 2002","Wed Dec 19 14:44:46 2001","pdb|1GER|B Chain B, Glutathione Reductase (E.C.1.6.4.2) Complex... 150 4e-037pdb|1GES|B Chain B, Glutathione Reductase (E.C.1.6.4.2) Nad Mut... 149 5e-037pdb|1EBD|A Chain A, Dihydrolipoamide Dehydrogenase Complexed Wi... 147 2e-036","SMU.140","","Residues 1 to 291 (E-value = 1.6e-41) place SMu0126 in the Pyr_redox family which is described as Pyridine nucleotide-disulphide oxidoreductase (PF00070)Residues 321 to 427 (E-value = 5.6e-08) place SMu0126 in the Pyr_redox_dim family which is described as Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (PF02852)","Wed Dec 19 14:44:46 2001","24378658","","","","Fri Jan 11 14:10:03 2002","","1","","","SMU.140","" "SMu0127","146430","147131","702","ATGCAGGATTCGAAACTAAAAGAACTAGAAGACGAAGTCAGTCGCTTTGGAACACATCAAATAAAAGGCATTGCTTATTTTCTTACTCTGCTTGGCGGAGCTATTGATGCGGTTTCCTATATGGGTTTTGATCATACCCTGCCGGCTGCTCAGACAGGAAATCTTCTTCTTTTAATGGTGGATATCACGCGCCTGAATGTACAAGGGATTGCCATAAAAATGACTACTCTGCTGAGCTTCATAGCGGGCTTGGTGGTCAGTCGCTGTGCTTACCACTATTATAGGAGTATCTATTGGCGTATTTATATCTTAGTGGGGTTATCGGCTGCTTGTCTCTTTACTTTCCTAGCTTTTGACCATCTTCCAAGTGGCCTTGCTATTGCACCTTTGTCCTTTACATTGGCAATGACGACAGGGGCTTTTAATAAGGTTGAAAATGAACTTTATAACAACTCGTTCACCACAGGGAATATCAAAAAAGCCATCATTGCTTGGTGTGAGTTCCTTTTTAAAGGACAGGCAGAGCAGAAGGAGCGAGCTGTCATTTTTACTTGCCTAGTTCTGTCCTTTGTCATAGGGGCATTTACAGCAGCCTTATTTTATTTCTTATTTGGGATGGCTGCCTTATTAGTTATACTATGCGAAATTATCATTTTTACAGTTTGCTACTTCTTGCTGATCAGATTTTCACAGAAATCCTAA","8.00","2.67","25978","MQDSKLKELEDEVSRFGTHQIKGIAYFLTLLGGAIDAVSYMGFDHTLPAAQTGNLLLLMVDITRLNVQGIAIKMTTLLSFIAGLVVSRCAYHYYRSIYWRIYILVGLSAACLFTFLAFDHLPSGLAIAPLSFTLAMTTGAFNKVENELYNNSFTTGNIKKAIIAWCEFLFKGQAEQKERAVIFTCLVLSFVIGAFTAALFYFLFGMAALLVILCEIIIFTVCYFLLIRFSQKS","147128","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins. Residues 18-219 are 28% similar to gi|15900971 in S.pneumoniae. Residues 23-223 are 26% similar to gi|16802494 from L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2169 (5e-23).","

InterPro
IPR010699
Family

Protein of unknown function DUF1275
PF06912	$\"[22-224]T$	DUF1275

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 24-210 are 26% similar to a (PROTEOME COMPLETE) protein domain (PD119110) which is seen in Q9CDY8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:16:44 2002","Wed Dec 19 15:19:36 2001","Wed Dec 19 15:22:09 2001","Wed Dec 19 15:19:36 2001","","Wed Dec 19 15:19:36 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0127 is paralogously related (blast p-value < 1e-3) to SMu1961, a conserved hypothetical.","Wed Dec 19 15:22:52 2001","","No significant hits to the NCBI PDB database.","SMU.141","","Residues 22 to 224 (E-value = 2.7e-72) place SMu0127 in the DUF1275 family which is described as Protein of unknown function (DUF1275) (PF06912)","Wed Dec 19 15:19:36 2001","24378659","","","","","","1","","","SMU.141","" "SMu0128","147909","147295","615","ATGTCTGCTATTAAAACTATTACTAAAGCCAGTCATTTAATTGATATGAATGATATTATTCGCGAAGGTCATCCTACCCTACGCGCTGTCGCTCAAGATGTCACCTTCCCTTTAAATGAAGATGATATTATTTTGGGCGAAAAAATGCTGCAATTCTTAAAAAATTCACAAGATCCCGTGACTGCTGAAAAAATGGAGCTGCGCGGCGGTGTCGGTCTCGCTGCTCCGCAATTAGATATTTCAAAACGCATCATTGCTGTTCTCATTCCTAATCCAGAAGATAAAGACGGCAATCCGCCTAAAGAAGCCTATGCCTTGAAAGAAGTTATGTACAACCCTCGAATTATTGCCCATTCTGTCCAAGATGCTGCCTTAGCTGATGGTGAAGGGTGTTTATCTGTTGATCGCGTGGTTGAAGGCTATGTTATCCGCCATTCCCGTGTCACTATTGAATACTATGACAAGAACAGCGACAAAAAGAAGCTCAAACTGAAAGGATATCAGTCGATCGTTGTCCAGCACGAAATTGATCATACCAACGGTATTATGTTTTTTGACCGCATCAATGAAAAAAATCCTTTTGAAATAAAAGAAGGTTTACTTTTGATTGAGTGA","5.70","-4.59","22904","MSAIKTITKASHLIDMNDIIREGHPTLRAVAQDVTFPLNEDDIILGEKMLQFLKNSQDPVTAEKMELRGGVGLAAPQLDISKRIIAVLIPNPEDKDGNPPKEAYALKEVMYNPRIIAHSVQDAALADGEGCLSVDRVVEGYVIRHSRVTIEYYDKNSDKKKLKLKGYQSIVVQHEIDHTNGIMFFDRINEKNPFEIKEGLLLIE","147298","","polypeptide deformylase (PDF)","Cytoplasm","Several matches in gapped BLAST to polypeptide deformylases, e.g. residues 1-204 are 71% similar to the enzyme from S.pneumoniae (gi15903353) and 69% similar to the enzyme from S.pyogenes (gi15675756).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1895 (2e-88).","

InterPro
IPR000181
Family

Formylmethionine deformylase
PD003844	$\"[69-183]T$	Fmet_deformylase
PR01576	$\"[59-88]T$ $\"[129-140]T$ $\"[142-160]T$ $\"[161-190]T$	PDEFORMYLASE
G3DSA:3.90.45.10	$\"[2-203]T$	Fmet_deformylase
PIRSF004749	$\"[16-203]T$	Pep_def
PTHR10458	$\"[20-204]T$	Fmet_deformylase
PF01327	$\"[16-194]T$	Pep_deformylase
TIGR00079	$\"[16-202]T$	pept_deformyl
SSF56420	$\"[1-203]T$	Fmet_deformylase

","BeTs to 12 clades of COG0242COG name: N-formylmethionyl-tRNA deformylaseFunctional Class: JThe phylogenetic pattern of COG0242 is -----qvceBrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000181 (Formylmethionine deformylase) with a combined E-value of 4.5e-37. IPB000181A 47-87 IPB000181B 110-125 IPB000181C 142-188","Residues 26-184 are 69% similar to a (DEFORMYLASE POLYPEPTIDE HYDROLASE) protein domain (PD003844) which is seen in Q9F2F0_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 17:20:02 2006","Thu Aug 31 17:20:02 2006","Thu Aug 31 17:20:02 2006","Thu Aug 31 17:20:02 2006","Wed Dec 19 15:23:47 2001","Wed Dec 19 15:23:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0128 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 15:26:20 2001","","No significant hits to the NCBI PDB database.","SMU.143c","","Residues 16 to 194 (E-value = 2.8e-85) place SMu0128 in the Pep_deformylase family which is described as Polypeptide deformylase (PF01327)","Wed Dec 19 15:23:47 2001","24378660","","","Mazel D, Coic E, Blanchard S, Saurin W, Marliere P.A survey of polypeptide deformylase function throughout the eubacterial lineage.J Mol Biol. 1997 Mar 14;266(5):939-49.PMID: 9086272 Mazel D, Pochet S, Marliere P.Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation.EMBO J. 1994 Feb 15;13(4):914-23.PMID: 8112305 ","","Wed Dec 19 15:31:08 2001","1","","","SMU.143c","605" "SMu0129","148631","147984","648","GTGGCTCCCAAAAAAGAATGGATTCAAAAGTATCAGTTAGAAAAGATTTTTCCTGCCCATTACTTTGATAAACTGCAAATGATTTCTTTTTCAGCTGGCCAAGCCATTTGTCAGCAGGGAGAAGAATTACAGGCTCTTTCTTATTTTGTCAAGGGTAAAATCAAGATTGTCCGGCGGCTGTTTAATGGCAAGGAACATATTCTTAATATTCAGGAAAAACCCACCATTATTGGAGATATTGAACTGCTAACAAATCAAGGAATCGTTTCTTCAGTAGTAGCCCTTGAAAAATCTTGGGTTGTCCAATTGCCGCTAAAAAGCAATAAAGAATTACTCTTAAAAGATCCTCTTTTTCTTCTTAAATTGGGACAAGGCTTAGCGTATTCACTCTACCAACAAAATATTAAGGCTTCAACCAATCTCTCTTATACAGTCAAAGAACGTTTAGCCAGTCATATTCTATCTATTCAAAAAGATGGGATTTTCCAATTAGAATTAGGCACCTTGGCTGACTCTTTTGGGGTTAGCTATCGCCATCTGCTGCGTGTTATTCAGGAATTTATAGCTCTTGGTGTCATTGGTAAGCAAAAGCCTTATTATTATATTAACAATCTAAAACAACTTAAACGCTGGCAAATTAAAGAATAA","10.40","11.91","24692","MAPKKEWIQKYQLEKIFPAHYFDKLQMISFSAGQAICQQGEELQALSYFVKGKIKIVRRLFNGKEHILNIQEKPTIIGDIELLTNQGIVSSVVALEKSWVVQLPLKSNKELLLKDPLFLLKLGQGLAYSLYQQNIKASTNLSYTVKERLASHILSIQKDGIFQLELGTLADSFGVSYRHLLRVIQEFIALGVIGKQKPYYYINNLKQLKRWQIKE","147987","","possible transcriptional regulator","Cytoplasm","Single significant match in gapped BLAST to a proposed transcriptional regulator from E.coli (gi|15802719). Residues 26-208 are 30% to this sequence.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1894 (4e-64).","

InterPro
IPR000595
Domain

Cyclic nucleotide-binding
PF00027	$\"[27-117]T$	cNMP_binding
SM00100	$\"[8-127]T$	cNMP
PS50042	$\"[22-112]T$	CNMP_BINDING_3

InterPro
IPR012318
Domain

Helix-turn-helix motif, Crp-type
PS51063	$\"[143-206]T$	HTH_CRP_2

InterPro
IPR014710
Domain

RmlC-like jelly roll fold
G3DSA:2.60.120.10	$\"[13-132]T$	no description

","BeTs to 5 clades of COG0664COG name: cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinasesFunctional Class: TThe phylogenetic pattern of COG0664 is a---YQvCEbRH-----Lin-Number of proteins in this genome belonging to this COG is 2","***** IPB001808 (Bacterial regulatory proteins, Crp family) with a combined E-value of 1.2e-08. IPB001808A 40-91 IPB001808B 162-193","Residues 40-158 are 25% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD080688) which is seen in YEIL_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 3 15:28:46 2003","Wed Dec 19 15:37:01 2001","Fri Jan 3 15:28:46 2003","Fri Jan 3 15:28:46 2003","Wed Dec 19 15:37:01 2001","Wed Dec 19 15:37:01 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0129 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 15:37:01 2001","","No significant hits to the NCBI PDB database.","SMU.144c","","Residues 24 to 117 (E-value = 3.1e-09) place SMu0129 in the cNMP_binding family which is described as Cyclic nucleotide-binding domain (PF00027)","Wed Dec 19 15:37:01 2001","24378661","","","","","","1","","","SMU.144c","861" "SMu0130","148736","149920","1185","ATGAAAGCGTTCATGGAGAAATTTAGTCTCTTATCCTTATCGTTAATGCTGGTGTCCACTTTTGCCGTTTCACCGGCACTTCCTAAGATGCTTTCTTTTTATCAAACACGCGGTTACAGTAATGCTCAAGTTGAATTGCTGCTTTCTTTATCTTCTTTTGCTATATTAGCGGTCTTACTGCTGAATCCTTGGATCAATCTATGGCTGTCGGAACGCTGGTCTATTATTTTAGGCTTGCTTTTGCTTTCTATAGGCGGTAGTTTACCCGTTTTTCTGCAGTTTTATCCTTTAGTTTTCCTGTCGCGTTTACTTTTAGGTTTGGGAATAGGTCTTATTAATGCGCGAGCGATTAGTATGATTAGCGAACGTTTTTCAGGCAAAATCAGAGTTCAAATGTTAGGATTAAGAGGTTCGGCAGAAGTTCTAGGATCAGCTATTTTAACCTTTTTAGCAGGACAGTGGCTGAATGTTTCCTGGTCTTTTGCTTTTTTAATTTATGGATTTGGCTTTCTTATTTTATTATGCTACCTCTTATTTGTGCCAGCAGCTAAAGGAAAAAGAGAGAGTTCCCAAAGGCAGATGTATTCAACTGCTTCTAAGAATCATTTTACCTTCCGTCAGCTCCTTTATATTTTTGGTTTGGCTCTCTATGCTGGTTTTGTTATTTTGGTTAATTCTGCTAATACCCTACGGATTCCTCTTGTTGTGGAGAAGTTACATTTGGCAACAGCCAGTCAAGCCAGTTTCATTTTAAGTCTGATGATGTTGATGGGCATTTTGGCCGGCACACTTTTTAGTTTTTTGCTAGCTTTATTTAAAGATTACCTAATGCCGCTAGTTGTATTCGTTTTGGGTTTGGGTATGCTGATACTTTGGCAGGCTAATCATTTATGGCTTTTAAGCCTTGGAGCTTTGGTGACCGGTTTTGTATACAGTTTAGGCGTTACCTTGGTTTTCCATCTTCTTTCAGAACATATGCCTAGGAAACAGTTGACAACGGCGACAACCTTGATTTTGATTGGCTGTAATTTAGGCGGCGGCTGTGCTTCTTTTGTCCTGCAGCTGTTTGCATGTATTAATTCAGATGTAAAAGCAGCCTTTCTTATTTTTGCTGTTTTGAGTTTGATCCTTGGTACTTTATTGCTGATAAGAGTGCTTAAAACAAATAGAAATCTCAGAAAATAA","10.90","19.00","43517","MKAFMEKFSLLSLSLMLVSTFAVSPALPKMLSFYQTRGYSNAQVELLLSLSSFAILAVLLLNPWINLWLSERWSIILGLLLLSIGGSLPVFLQFYPLVFLSRLLLGLGIGLINARAISMISERFSGKIRVQMLGLRGSAEVLGSAILTFLAGQWLNVSWSFAFLIYGFGFLILLCYLLFVPAAKGKRESSQRQMYSTASKNHFTFRQLLYIFGLALYAGFVILVNSANTLRIPLVVEKLHLATASQASFILSLMMLMGILAGTLFSFLLALFKDYLMPLVVFVLGLGMLILWQANHLWLLSLGALVTGFVYSLGVTLVFHLLSEHMPRKQLTTATTLILIGCNLGGGCASFVLQLFACINSDVKAAFLIFAVLSLILGTLLLIRVLKTNRNLRK","149917","","major facilitator superfamily transporter, efflux protein","Membrane, Extracellular","Single significant hit in gapped BLAST to a hypothetical, a possible efflux transporter, from S.pneumoniae (gi15901440).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1892 (9e-48).","

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[1-389]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[9-358]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[6-394]T$	PTHR10074
SSF103473	$\"[1-390]T$	SSF103473

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Aug 18 17:19:28 2006","Fri Aug 18 17:19:28 2006","Fri Aug 18 17:19:28 2006","Wed Dec 19 15:39:24 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0130 is paralogously related (blast p-value < 1e-3) to SMu1287, SMu1173, SMu0119, and SMu1310, hypotheticals and predicted permeases.","Wed Dec 19 15:42:02 2001","","No significant hits to the NCBI PDB database.","SMU.145","","No significant hits to the Pfam 11.0 database","Wed Dec 19 15:39:24 2001","24378662","","","","","","1","","","SMU.145","731" "SMu0131","150120","152789","2670","ATGGCAAAAGAAACAAAAACAGAAGCACTCACTGCTGAAGAAGCAGCTAAGCAGTATACGAATAGCTTAGTTGAAAAAGCGTTAAAGGCTGAAAAAGTTTATGCAACTTATACACAAGAACAGGTAGATAAAATTGTTGCAGCTATGGCGCTTGCTGGTTCTGAGGCGTCCCTGCAGTTAGCTAAAGAAGCTCACGATGAAACAGGCCGTGGGGTTGTCGAAGATAAAGATACTAAAAACCACTTTGCGACAGAATATGTATATGAACGCATAAAAAATGAAAAAACGGTTGGCATCATTGGTGAAGATAAAGTTGCTGGCAGTATCGAAATTGCAGCACCACTTGGTGTCTTGGCAGGTATCGTACCAACAACTAACCCAACATCAACGACTATGTTTAAAATCTTAGTCGCATTGAAAACACGCAATGCAATCGTCTTTGCTTTCCACCCAGCAGCTCAAAAATGTTCTGCTCATGCCGCCCAAATCTTGTATGACGCGGCGGTTAAAGCCGGCGCTCCTGAAAATATTGTTCAATGGATTGAAACACCATCCATCGCAAACACGGGAGCTTTGATTTCCAACAAAGGCATTGCTTCAATCCTTGCAACTGGCGGACCTGGCATGGTTAATGCAGCCCTTAAATCTGGTAATCCATCGATGGGTGTTGGTGCAGGTAATGGTGCTGTTTATGTGGATGCAACTGCTAATCTTGAACGTGCGGTTGAAGACCTTCTTCTTTCTAAGCGTTTTGACAATGGTATGATTTGTGCGACTGAAAATTCGGCAGTTGTGGAAGCACCAATTTATAAAGAATGGCTTGCTAAAATGCAGGAAAAAGGCGCTTACCTTGTTCCTAAAAAAGATTACAAAAAATTTGAAGATTTTGTTTTTAATGACAACCATGGTGTTAACGGACCGGTTGCTGGTATGTCGGCGAAATGGATCTGTGAACAAGCCGGTGTGACATTGCCAGAAGGCAAAGATGTTCTCTTATTTGAACTTGATAAGAAAAAAATTGGTGAGAAATTATCATCAGAAAAACTCTCTCCGCTTCTTTCTGTTTATAAAGCCAAAGATCGCAAAGATGGTATTGATATTGTAGCAGCCCTTCTTGATTACCAAGGTGCTGGTCATAACTGTGCTATCCAAATCGGTTCACAAGCTGACCCATTTGTCGCTGAATATGGAGATGCCCTCAATTCATCTCGTGTTTTGGTTAACCAACCAGACTCAGTCGGTGGTATCGGTGACGTTTATACAGACGCATTGCAAGCCAGCTTAACTCTTGGAACAGGATCATGGGGGAAAAATTCATTGTCACACAACTTATCTACTGGCGACCTCTTGAATGTGAAAACTGTTGCGAAACGCCGCAACCGTCCTCAATGGGTTCGTTTACCAGAAAAAACTTACTACGAAAAAAATGCTATTTCATACTTGCAGGATGAAACTGAAACAATGACGCGTGCTATCATCGTTGCCGACCCAGGTATGCTTCAATTTGGTTTTGTTGACACTGTCCTTGCTCAGCTGTCCCTTCGGGATGAAAAAGTGGCAACTTCAATTTATGGTACTATTAAACCAGATCCAACACTCGGTCAGACTATTGAAATTGCTAGACAAATGCGTGACTTCAAACCAGATACTGTTATTGCAGTTGGTGGCGGTTCTGCCCTTGATGCAGCCAAAATTGCGCGTTATATCTATGAATATTCGTTGGATCAAGAAGCAGATTTCCTTGATAGTTATGAAAAAGTCAGTGAGCTCTTCCTTGAATTGCAGCAAAAATTCATTGATATTCGTAAGCGGATTGTTCGCTTCAAGCATCAGACAGTGACTCGTCTCTTCTGTATCCCAACAACATCTGGTACGGGTTCAGAAGTGACACCTTATGCCGTTATTACTGATGATTTCACACACGTGAAATACCCATTGACTGATTATGAATTGACACCGCAAGTTGCTATTGTTGATCCAGAATTTGTCATGACAGTGCCTAAACGTACAGTAGCTCTTTCAGGACTTGATACTTTGTCACATGCTCTTGAATCTTACGTATCTGTTATGGCATCTGATTTCACACGTCCATGGTCTATGGAAGCTATCAGATTGGTTATCGAAAACTTGGAAGATTCTTATAACTTTGATCCTAAGAATCCAACACTTCGTGGAGAACAAGCACGTGAAAACATGCATTATGCAGCAACTTTAGCAGGTATGGCCTTCTCAAATGCCTTCCTTGGAATTAACCACTCACTCGCCCACAAGGCTGGCGGTGAATTTGGACTTCCTCATGGTCTTGCTATCTCAATTGCTATGCAGCATGTTATTCGCTACAATGGCGTTGCAGGAAATGTGAAACGTTCTGTTTACCCGCGTTATGAAGAATACCGTGCCCAACGTGATTATGCGGATATTGCTCGCGCTCTTGGACTTAAAGGGAAAGATGATGCAGAATTGGTTGAAGCACTCTGTGCACGTATTGATCAATTAATGCATGCTGTAGATGTTGAGCCTAAGTTATCTGCTAATGGGGTTACTAAGAAGGCTTTTGATGCAGCTGTTGATAGATTGGCAAGCTTGGCTTATGATGATCAATGTACACCAGCTAATCCACGTCAGCCTTACATTGAAGAGATGAAGCAGCTCTTGATTGATCAGTTCTAA","5.50","-15.38","96988","MAKETKTEALTAEEAAKQYTNSLVEKALKAEKVYATYTQEQVDKIVAAMALAGSEASLQLAKEAHDETGRGVVEDKDTKNHFATEYVYERIKNEKTVGIIGEDKVAGSIEIAAPLGVLAGIVPTTNPTSTTMFKILVALKTRNAIVFAFHPAAQKCSAHAAQILYDAAVKAGAPENIVQWIETPSIANTGALISNKGIASILATGGPGMVNAALKSGNPSMGVGAGNGAVYVDATANLERAVEDLLLSKRFDNGMICATENSAVVEAPIYKEWLAKMQEKGAYLVPKKDYKKFEDFVFNDNHGVNGPVAGMSAKWICEQAGVTLPEGKDVLLFELDKKKIGEKLSSEKLSPLLSVYKAKDRKDGIDIVAALLDYQGAGHNCAIQIGSQADPFVAEYGDALNSSRVLVNQPDSVGGIGDVYTDALQASLTLGTGSWGKNSLSHNLSTGDLLNVKTVAKRRNRPQWVRLPEKTYYEKNAISYLQDETETMTRAIIVADPGMLQFGFVDTVLAQLSLRDEKVATSIYGTIKPDPTLGQTIEIARQMRDFKPDTVIAVGGGSALDAAKIARYIYEYSLDQEADFLDSYEKVSELFLELQQKFIDIRKRIVRFKHQTVTRLFCIPTTSGTGSEVTPYAVITDDFTHVKYPLTDYELTPQVAIVDPEFVMTVPKRTVALSGLDTLSHALESYVSVMASDFTRPWSMEAIRLVIENLEDSYNFDPKNPTLRGEQARENMHYAATLAGMAFSNAFLGINHSLAHKAGGEFGLPHGLAISIAMQHVIRYNGVAGNVKRSVYPRYEEYRAQRDYADIARALGLKGKDDAELVEALCARIDQLMHAVDVEPKLSANGVTKKAFDAAVDRLASLAYDDQCTPANPRQPYIEEMKQLLIDQF","152786","For other 'adh' genes see SMu0107 (adh);SMu0113 (adhA); SMu0114 (adhB); SMu0115 (adhC); SMu0116 (adhD); SMu1698 (adhB) and SMu1299 (adhD).","alcohol-acetaldehyde dehydrogenase","Cytoplasm, Extracellular","A fragment of this sequence corresponds to the previously published gi1661189 in GenBank. Residues 661-716 are identical to residues 1-56 of gi1661189.Numerous matches in gapped BLAST to alcohol-acetaldehyde dehydrogenases. Residues 19-889 are 68% similar to the enzyme from Lactococcus (gi3242238). Residues 23-889 are 47% similar to the enzyme from L.innocua (gi16800743).This sequence is similar to Spy0042.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0053 (0.0).","

InterPro
IPR001670
Domain

Iron-containing alcohol dehydrogenase
PF00465	$\"[468-881]T$	Fe-ADH
PS00913	$\"[656-684]T$	ADH_IRON_1

InterPro
IPR012079
Family

Bifunctional aldehyde/alcohol dehydrogenase
PIRSF000111	$\"[12-889]T$	ALDH_ADH

noIPR
unintegrated

unintegrated
G3DSA:1.20.1090.10	$\"[668-887]T$	G3DSA:1.20.1090.10
G3DSA:3.40.50.1970	$\"[460-667]T$	G3DSA:3.40.50.1970
G3DSA:3.40.605.10	$\"[5-265]T$	G3DSA:3.40.605.10
PTHR11496	$\"[630-781]T$	PTHR11496
SSF53720	$\"[16-466]T$	SSF53720
SSF56796	$\"[457-887]T$	SSF56796

","BeTs to 3 clades of COG1012COG name: NAD-dependent aldehyde dehydrogenasesFunctional Class: CThe phylogenetic pattern of COG1012 is -mt-Yq-CEBR-uj-------Number of proteins in this genome belonging to this COG is 3","***** IPB001670 (Iron-containing alcohol dehydrogenase) with a combined E-value of 1.2e-35. IPB001670A 549-561 IPB001670B 621-630 IPB001670C 653-686 IPB001670D 752-767***** IPB002086 (Aldehyde dehydrogenase family) with a combined E-value of 8.6e-10. IPB002086A 114-127 IPB002086C 198-218 IPB002086D 228-271","Residues 615-706 are 77% similar to a (DEHYDROGENASE OXIDOREDUCTASE ALCOHOL NAD COMPLETE) protein domain (PD001480) which is seen in O86282_BBBBB.Residues 490-564 are 40% similar to a (SYNTHASE 3-DEHYDROQUINATE DEHYDROGENASE LYASE PROTEOME) protein domain (PD002227) which is seen in Q9CKZ7_PASMU.Residues 725-820 are 72% similar to a (DEHYDROGENASE OXIDOREDUCTASE ALCOHOL NAD COMPLETE) protein domain (PD001437) which is seen in O86282_BBBBB.Residues 23-185 are 73% similar to a (DEHYDROGENASE ALCOHOL OXIDOREDUCTASE) protein domain (PD011559) which is seen in O86282_BBBBB.Residues 418-478 are 86% similar to a (DEHYDROGENASE ALCOHOL PROTEOME) protein domain (PD008645) which is seen in Q9CDR3_LACLA.Residues 281-417 are 28% similar to a (DEHYDROGENASE OXIDOREDUCTASE ALCOHOL) protein domain (PD332673) which is seen in ADHE_ECOLI.Residues 494-565 are 68% similar to a (DEHYDROGENASE ALCOHOL OXIDOREDUCTASE COMPLETE PROTEOME) protein domain (PD357627) which is seen in Q9CDR3_LACLA.Residues 727-826 are 34% similar to a (DEHYDROGENASE NADPH-DEPENDENT BUTANOL) protein domain (PD393783) which is seen in Q9XYL4_TRIVA.Residues 822-889 are 54% similar to a (DEHYDROGENASE ALCOHOL PROTEOME) protein domain (PD094797) which is seen in Q9CDR3_LACLA.Residues 280-417 are 59% similar to a (DEHYDROGENASE ALCOHOL) protein domain (PD396883) which is seen in Q9CDR3_LACLA.Residues 191-279 are 85% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD000218) which is seen in Q9CDR3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 08:28:44 2006","Wed Dec 19 15:43:28 2001","Thu Sep 7 08:28:44 2006","Thu Apr 4 14:18:53 2002","Wed Dec 19 15:43:28 2001","Wed Dec 19 15:43:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0131 is paralogously related (blast p-value < 1e-3) to SMu0408, a predicted gamma-glutamyl phosphate reductase.","Wed Dec 19 15:53:08 2001","","No significant hits to the NCBI PDB database.","SMU.148","","Residues 468 to 881 (E-value = 1.3e-111) place SMu0131 in the Fe-ADH family which is described as Iron-containing alcohol dehydrogenase (PF00465)","Wed Dec 19 15:43:28 2001","24378663","","","","","","1","","","SMU.148","874" "SMu0132","152999","153301","303","GTGGAATTGTTCTACCATATTGTTTTCGCACTCAAGTATCATCGTCAAATCATTTATGGCAGATACAAAACCAGTATCGGAAGAATTATCTGGGACTTATGTGAACGCAAAGGCGTGACCATTCATGAAGCGAATGCCTGTTCCGATCATATTCATATGCTTGTCAGTATCGCTTCCAAATTCAGTGTTTCGTCTTTCATGGGATATTTAAAGGGAAAGAGCAGCTTGATGATTTTTGATAAGCATGCGAACTTAAAATACAAATATGGCAATCGAAGTTTTGGTGTAGAGGCTATTATGTAG","10.40","8.33","11564","MELFYHIVFALKYHRQIIYGRYKTSIGRIIWDLCERKGVTIHEANACSDHIHMLVSIASKFSVSSFMGYLKGKSSLMIFDKHANLKYKYGNRSFGVEAIM","153298","","transposase fragment (IS605/IS200-like)","Cytoplasm, Membrane","Several matches to transposase fragments in gapped BLAST. Residues 5-94 are 82% similar to gi|15612739 and many other entries representing B.halodurans. These residues are also 76% similar to gi|15896768 from C.acetobutylicum (IS605/IS200-like).SMu0132 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002686
Family

Transposase IS200-like
PD003831	$\"[3-54]T$	Q82PQ1_STRAW_Q82PQ1;
PF01797	$\"[8-99]T$	Transposase_17

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 8-94 are 81% similar to a (TRANSPOSASE PROTEOME COMPLETE IS200) protein domain (PD003831) which is seen in Q9JWR7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:20:51 2002","Fri Dec 21 14:05:31 2001","Fri Dec 21 14:05:31 2001","Fri Dec 21 14:01:28 2001","","Fri Dec 21 14:01:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0132 is paralogously related (blast p-value < 1e-3) to SMu1244, a transposase-related sequence.","Fri Dec 21 14:06:35 2001","","No significant hits to the NCBI PDB database.","SMU.149","","Residues 8 to 99 (E-value = 3.6e-32) place SMu0132 in the Transposase_17 family which is described as Transposase IS200 like (PF01797)","Fri Dec 21 14:01:28 2001","24378664","","","","","","1","","","SMU.149","" "SMu0133","153813","154016","204","ATGGATACACAGGCATTTGAACAATTTGATGTAATGGACAGCCAAACACTTTCAACTGTTGAAGGTGGGAAGGTATCGGGTGGAGAAGCAGTCGCGGCAATTGGAATATGTGCAACTGCTTCAGCAGCAATTGGAGGACTGGCAGGTGCGACTCTTGTTACCCCATATTGTGTAGGCACTTGGGGACTCATTCGATCTCATTAA","4.10","-3.87","6673","MDTQAFEQFDVMDSQTLSTVEGGKVSGGEAVAAIGICATASAAIGGLAGATLVTPYCVGTWGLIRSH","154013","This gene is said to be induced by the competence system (kreth et al., 2005).","non-lantibiotic mutacin IV A","Cytoplasm, Extracellular","No similarities are found in the NR database at this time. This sequence corresponds to GI:24376526 in GenBank and is defined by Qi et al., 2001 to be a non-lantibiotic mutacin IV gene.SMu0133 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[30-64]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[56-76]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-27]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[41-61]?$ $\"[76-96]?$ $\"[110-128]?$	transmembrane_regions

InterPro
IPR000589
Family

Ribosomal protein S15
PF00312	$\"[6-88]T$	Ribosomal_S15
PS00362	$\"[39-69]T$	RIBOSOMAL_S15

InterPro
IPR005290
Family

Ribosomal protein S15, bacterial chloroplast and mitochondrial type
PD157043	$\"[10-88]T$	Ribosomal_S15_b
PTHR23321:SF10	$\"[4-88]T$	Ribosom_S15_bac
TIGR00952	$\"[4-89]T$	S15_bact

InterPro
IPR009068
Domain

S15/NS1, RNA-binding
G3DSA:1.10.287.10	$\"[2-89]T$	S15_NS1_RNA_bd
SSF47060	$\"[2-89]T$	S15/NS1_bind

noIPR
unintegrated

unintegrated
PTHR23321	$\"[4-88]T$	PTHR23321

","BeTs to 16 clades of COG0184COG name: Ribosomal protein S15P/S13EFunctional Class: JThe phylogenetic pattern of COG0184 is amtkYqvcebrHujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000589 (Ribosomal protein S15) with a combined E-value of 1.7e-24. IPB000589 26-71","Residues 10-89 are 82% similar to a (RIBOSOMAL 30S RRNA-BINDING CHLOROPLAST PROTEOME) protein domain (PD157043) which is seen in Q9CEF6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:23:18 2002","Fri Dec 21 14:13:39 2001","Fri Dec 21 14:19:40 2001","Thu Apr 4 14:49:58 2002","Fri Dec 21 14:13:39 2001","Fri Dec 21 14:13:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0137 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 21 14:19:40 2001","Fri Dec 21 14:13:39 2001","pdb|1A32| Ribosomal Protein S15 From Bacillus Stearothermophi... 115 1e-027pdb|1FKA|O Chain O, Structure Of Functionally Activated Small R... 110 4e-026pdb|1QD7|H Chain H, Partial Model For 30s Ribosomal Subunit 110 5e-026","SMU.154","","Residues 6 to 88 (E-value = 2.4e-33) place SMu0137 in the Ribosomal_S15 family which is described as Ribosomal protein S15 (PF00312)","Fri Dec 21 14:13:39 2001","24378669","","","","","","1","","","SMU.154","753" "SMu0138","157228","159420","2193","ATGTCAAAACAAGTGTTTGAAACAATTTTTGCTGGCAAAAAGCTGGCTGTAGAAATCGGTCAGGTTGCCAAACAAGCCAATGGTGCTGCTTTGGTTCGTTATGGTGATTCAACGGTCTTGAGTGCTGCAGTTATGTCTAAAAAAATGTCCACAGGCGATTTCTTCCCACTTCAGATTAATTATGAAGAAAAAAGATACGCAGCTGGGAAATTCCCCGGTGGCTTTAACAAGCGTGAAGGCCGGCCATCAACCGATGCTACTTTAACGGCTCGCTTAATTGATCGTCCGATTCGTCCCATGTTTGCGGAAGGTTTTCGCAATGAAGTCCAAGTCATTAATACAGTTCTGTCTTATGATGCTGATGCGAGTGCTCCTATGGCGGCTATGTTTGGCAGTTCACTAGCACTTTCGATTTCAGATATTCCTTTTAATGGCCCGATTGCTGGGGTACAAGTTGCTTACCTTGATGGTCAATATGTTATTAATCCTACGGCTGAAGAAAAGAAAGCTTCACTTTTAGAATTGACTGTCGCCGGAACCAAGGAAGCCATCAATATGGTTGAGTCTGGTGCTAAGGAATTGTCAGAAGATATCATGCTTGAAGCCCTTCTCAAAGGACATGAAGCGGTACGTGAACTAATTGCTTTCCAAGAGGAAATTATAGCAGCTGTTGGTAAAGAAAAAGCTGAAGTTGAATTGTTACAGGTGGATGCTGATTTGCAGGCTGAAATTGTTGGAAAATACAATGCAGACCTTCAAAAGGCTGTCCAAATTGAGGAAAAGAAAGCCCGCGAAATTGCGACAGAAGCTGTCAAAGAGCACGTGACTGCTGAATATGAAGAACGCTATGCTGAACACGAGGAACATGACCGTATCATGCGCGACGTAGCTGAAATCCTTGAACAGATGGAACACGCAGAGGTTCGCCGTCTTATCACAGAAGACAAGGTTCGTCCTGACGGTCGTCGTGTTGATGAAATCCGTCCGCTTGATGCAGAGATTGATTTCTTGCCAAAAGTACATGGTTCAGGTCTCTTTACTCGTGGACAAACCCAAGCCTTGTCAGTGTTAACATTGGCTCCAATGGGAGATACCCAAATTGTGGACGGGCTTGACGAAGAATATAAAAAACGCTTCATGCATCATTATAATTTCCCGCAATATTCGGTTGGGGAAACGGGACGGTATGGAGCGCCAGGACGCCGAGAAATCGGTCATGGAGCTCTTGGTGAACGTGCTTTGGCTCAAGTTCTGCCAAGTTTGGAAGCATTTCCTTATGCCATTCGTTTGGTAGCTGAAGTGTTAGAATCAAACGGTTCCTCATCACAGGCTTCAATTTGTGCGGGAACGCTCGCTCTTATGGCTGGGGGTGTACCTATCAAAGCACCAGTTGCAGGTATTGCTATGGGACTTATCTCAGACGGCACTAACTATACCGTTTTGACCGATATCCAAGGACTAGAAGATCACTTCGGCGATATGGACTTTAAAGTTGCAGGTACCCGTGAAGGTATCACAGCTTTGCAAATGGATATTAAGATTGAGGGTATTACACCGCAGATTTTAGAAGAAGCTCTTGCCCAAGCTAAAAAAGCACGTTTTGAAATTCTTGATGTGATCGAAAAAGTCATTCCTGCACCACGTCTAGAATTAGCACCGACAGCACCTAAAATTGACACAATTAAAGTTGATGTTGATAAAATCAAGATTGTCATTGGCAAGGGCGGTGAAACCATTGATAAGATTATTGAAGAAACTGGCGTTAAGATTGATATTGATGAAGACGGTAATATTGCTATCTACTCTAGCGATCAAGAGGCTATCAATCGGACTAAGGAAATTATTGCAAGTTTGGTACGTGAAGCTAAGGTTGGTGAGATCTATGAAGCTGAAGTTGTCCGTATTGAGAAATTTGGTGCTTTTGTGCATCTTTTTGATAAGACAGATGCACTCGTTCACATCTCTGAAATAGCTTGGACCCGCACGAATAAAGTAGAAGATGTCTTGGCTGTTGGAGATAAGGTTACGGTCAAAGTTGTTAAGGTAGATGACAAAGGCCGTATTGATGCTTCCATGAAAGCTTTATTACCACGTCCGCCAAGATCTGAAAAGTCAAATAAGGAGGACCATCAATCTGTCAGACATCACGGTTCTCCTAAAGACGATAAAGGTAAAGAAAAATATGATAAATAA","5.00","-25.31","80049","MSKQVFETIFAGKKLAVEIGQVAKQANGAALVRYGDSTVLSAAVMSKKMSTGDFFPLQINYEEKRYAAGKFPGGFNKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDADASAPMAAMFGSSLALSISDIPFNGPIAGVQVAYLDGQYVINPTAEEKKASLLELTVAGTKEAINMVESGAKELSEDIMLEALLKGHEAVRELIAFQEEIIAAVGKEKAEVELLQVDADLQAEIVGKYNADLQKAVQIEEKKAREIATEAVKEHVTAEYEERYAEHEEHDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRRVDEIRPLDAEIDFLPKVHGSGLFTRGQTQALSVLTLAPMGDTQIVDGLDEEYKKRFMHHYNFPQYSVGETGRYGAPGRREIGHGALGERALAQVLPSLEAFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTREGITALQMDIKIEGITPQILEEALAQAKKARFEILDVIEKVIPAPRLELAPTAPKIDTIKVDVDKIKIVIGKGGETIDKIIEETGVKIDIDEDGNIAIYSSDQEAINRTKEIIASLVREAKVGEIYEAEVVRIEKFGAFVHLFDKTDALVHISEIAWTRTNKVEDVLAVGDKVTVKVVKVDDKGRIDASMKALLPRPPRSEKSNKEDHQSVRHHGSPKDDKGKEKYDK","159417","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu1814 (comX1);SMu0258 (comA); SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). ","polyribonucleotide nucleotidyltransferase alpha subunit (PNPase)","Cytoplasm","Numerous similarities in gapped BLAST to PNPase sequences. Residues 1-708 are 81% similar to the protein from S.pyogenes (gi15675748). Residues 1-728 are 78% similar to gi15902560 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0203 (0.0).","

InterPro
IPR001247
Domain

Exoribonuclease
PF01138	$\"[11-142]T$ $\"[326-459]T$	RNase_PH
PF03725	$\"[145-209]T$ $\"[462-532]T$	RNase_PH_C
PF03726	$\"[240-323]T$	PNPase
SSF46915	$\"[236-324]T$	3_ExoRNase
SSF55666	$\"[143-236]T$ $\"[462-553]T$	3_ExoRNase

InterPro
IPR003029
Domain

RNA binding S1
PF00575	$\"[621-693]T$	S1
SM00316	$\"[623-693]T$	S1
PS50126	$\"[625-693]T$	S1

InterPro
IPR004087
Domain

KH
SM00322	$\"[555-620]T$	KH

InterPro
IPR004088
Domain

KH, type 1
PF00013	$\"[558-615]T$	KH_1
PS50084	$\"[556-615]T$	KH_TYPE_1

InterPro
IPR012162
Family

Polyribonucleotide nucleotidyltransferase
PIRSF005499	$\"[2-718]T$	PNPase
PTHR11252	$\"[143-709]T$	PNPase

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[620-695]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
G3DSA:1.10.10.400	$\"[235-322]T$	G3DSA:1.10.10.400
G3DSA:3.30.1370.10	$\"[557-619]T$	G3DSA:3.30.1370.10
SSF50249	$\"[612-699]T$	Nucleic_acid_OB
SSF54211	$\"[1-142]T$ $\"[325-461]T$	SSF54211
SSF54791	$\"[555-628]T$	SSF54791

","BeTs to 11 clades of COG1185COG name: Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)Functional Class: JThe phylogenetic pattern of COG1185 is -----qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 10-81 are 79% similar to a (NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE) protein domain (PD005304) which is seen in Q9CEI6_LACLA.Residues 220-300 are 59% similar to a (NUCLEOTIDYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD407002) which is seen in Q9CEI6_LACLA.Residues 396-442 are 95% similar to a (NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE) protein domain (PD111902) which is seen in Q9CEI6_LACLA.Residues 444-541 are 74% similar to a (NUCLEOTIDYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD002075) which is seen in Q9CEI6_LACLA.Residues 631-698 are 51% similar to a (RIBOSOMAL COMPLETE PROTEOME RNA-BINDING 30S REPEAT) protein domain (PD000709) which is seen in Q9CEI6_LACLA.Residues 548-628 are 58% similar to a (NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE) protein domain (PD023173) which is seen in Q9CEI6_LACLA.Residues 307-440 are 74% similar to a (NUCLEOTIDYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD333034) which is seen in PNP_BACSU.Residues 87-117 are identical to a (NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE) protein domain (PD005803) which is seen in Q9CEI6_LACLA.Residues 295-356 are 46% similar to a (NUCLEOTIDYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD406609) which is seen in Q9HV59_PSEAE.Residues 301-354 are 82% similar to a (NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE) protein domain (PD379184) which is seen in Q9CEI6_LACLA.Residues 359-394 are 83% similar to a (NUCLEOTIDYLTRANSFERASE POLYRIBONUCLEOTIDE) protein domain (PD416000) which is seen in Q9CEI6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 18 12:59:59 2006","Tue Jul 18 12:59:59 2006","Tue Jul 18 12:59:59 2006","Thu Apr 4 09:59:48 2002","","Fri Dec 21 14:20:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0138 is paralogously related (blast p-value < 1e-3) to SMu1097, a predicted 30S ribosomal s1 protein, SMu0682, a conserved hypothetical, and SMu0443, a predicted polynucleotide nucleotidyltransferase.","Fri Dec 21 14:37:58 2001","Tue Jul 18 12:59:59 2006","pdb1E3PA Chain A, Tungstate Derivative Of Streptomyces Antibi... 475 9e-135pdb1E3HA Chain A, Semet Derivative Of Streptomyces Antibiotic... 464 2e-131","SMU.155","","Residues 11 to 142 (E-value = 2.1e-31) place SMu0138 in the RNase_PH family which is described as 3' exoribonuclease family, domain 1 (PF01138)Residues 145 to 209 (E-value = 3e-16) place SMu0138 in the RNase_PH_C family which is described as 3' exoribonuclease family, domain 2 (PF03725)Residues 240 to 323 (E-value = 5.7e-06) place SMu0138 in the PNPase family which is described as Polyribonucleotide nucleotidyltransferase, RNA binding domain (PF03726)Residues 326 to 459 (E-value = 2.7e-41) place SMu0138 in the RNase_PH family which is described as 3' exoribonuclease family, domain 1 (PF01138)Residues 462 to 532 (E-value = 6.7e-26) place SMu0138 in the RNase_PH_C family which is described as 3' exoribonuclease family, domain 2 (PF03725)Residues 560 to 606 (E-value = 1.7e-10) place SMu0138 in the KH family which is described as KH domain (PF00013)Residues 621 to 693 (E-value = 2.8e-23) place SMu0138 in the S1 family which is described as S1 RNA binding domain (PF00575)","Tue Jul 18 12:59:59 2006","24378670","","","Jarrige AC, Mathy N, Portier C.PNPase autocontrols its expression by degrading a double-stranded structure in the pnp mRNA leader.EMBO J. 2001 Dec 3;20(23):6845-55.PMID: 11726520Symmons MF, Jones GH, Luisi BF.A duplicated fold is the structural basis for polynucleotide phosphorylase catalytic activity, processivity, and regulation.Structure Fold Des. 2000 Nov 15;8(11):1215-26.PMID: 11080643 ","","Fri Dec 21 14:31:37 2001","1","","","SMU.155","30" "SMu0139","159410","160150","741","ATGATAAATAAATTTAATAAAGAACTTGATATGGCACTCAGAAGTTTTATCAAGGAACCTGATAATTTTTTAAATAGTTTGACGCTTGTTAATAGTCTTCATTCTTTCCCTGTTTTGGCTAGTGATCAGCCTTATGCCATCGCCCTTGATGGTCAAAAAGTGACGCCAGTCTTTACAGATACGGAAGATTTGAAACTTTTTAAAGCACAGCAAACGAGTGCCAGAAAGCAAAATTGGGTAGAGCGTCCTAGTCTGGATATTTTAGAAGAAGTTATTGTCAATCGCTTGAATGGGATAGTCTATAATATTAAAAGAACAGGCGATTTTGGAAATTCCACGATTTTCAAAAGTAATGAATTGGTGCAATTTATCAATAATTACACTGTTATTCTCAACACTGTTTTTAATGAGACCAATCAAGAAGCTGATATCTTAGATAAATATTATCTAGTACCAGCTTTCATTCATCCTAAAGATAATGATGATTTTGATAAGGGCTTTCCTACTATGTCAAATTCAGATGGAGAAAGCTATGTTCCCATCTTTTCGAATTTGCCAAGTTTTGTTAAATGGTATCATGATAAAGAATTTGGTCTTCCTTTCAGAGAAGCACAAGGTGTTATTATGACTTGGAAAATTGCCGATATTCAAGAATCAGAAACGAAAGCCTCAACGTTAGGAGTAGTCATTAATCCTTTTGATGACAAACAAATTGTTGTTGAATGGTCGGGTATGGAATAA","4.50","-11.27","28136","MINKFNKELDMALRSFIKEPDNFLNSLTLVNSLHSFPVLASDQPYAIALDGQKVTPVFTDTEDLKLFKAQQTSARKQNWVERPSLDILEEVIVNRLNGIVYNIKRTGDFGNSTIFKSNELVQFINNYTVILNTVFNETNQEADILDKYYLVPAFIHPKDNDDFDKGFPTMSNSDGESYVPIFSNLPSFVKWYHDKEFGLPFREAQGVIMTWKIADIQESETKASTLGVVINPFDDKQIVVEWSGME","160147","","conserved hypothetical protein","Cytoplasm","Limited similarities in gapped BLAST to unknown proteins in Streptococcus and relatives. Residues 6-246 are 54% similar to gi|15675747 from S.pyogenes. Residues 5-241 are 34% similar to gi|15673836 from Lactococcus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0204 (5e-78).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-241 are 34% similar to a (PROTEOME COMPLETE) protein domain (PD401040) which is seen in Q9CEI7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:24:48 2002","Fri Dec 21 14:38:52 2001","Fri Dec 21 14:41:26 2001","Fri Dec 21 14:38:52 2001","","Fri Dec 21 14:38:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0139 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 21 14:41:26 2001","","No significant hits to the NCBI PDB database.","SMU.156","","No significant hits to the Pfam 11.0 database","Fri Dec 21 14:38:52 2001","24378671","","","","","","1","","","SMU.156","627" "SMu0140","160110","160778","669","ATGACAAACAAATTGTTGTTGAATGGTCGGGTATGGAATAAAGGAGATATTATGGGTTGGTGGAAAGAAACCATTGATATTGTTAAAGAAAAAGATCCCGCAGCACGGACGGCGCTAGAGGTTCTTTTGACTTACCCAGGTGTTAAGGCTTTAGCTGCTCATTGCTTATCTCATTTTTTGTGGACACACCATTGTAAATTGTTGGCTCGGATGCATAGTCAGTTTTGGCGTTTTTGGACACAAATTGAGATTCATCCAGGTGCTGAAATTGCAGAAGGCGTCTTTATTGATCACGGTTCAGGTTTAGTTATTGGTGAGACTGCCATCGTAGAAAAAGGGGTCATGCTTTATCATGGTGTGACACTTGGTGGTACGGGTAAAGAGACTGGAAAACGGCATCCAACGATTCGTCAAGGAGCTCTTATTTCTGCACATTCACAAGTTATTGGTCCGGTTGAGGTTGGTCCGGGCGCTAAGGTGGGTGCAGGTGCAGTCGTTGTTTCGGATGTTCCAGCAGACGTCACTGTGGTTGGTGTTCCAGCCAAGGTGGTTCGTATTCATGGTCAAAAAGATGAAACAGCTATCCATGAAATCGAAGAGAACCGTGAATATTACCTCAAAAAACTAGAAGAAGCTAAGGAAGCTAGTTTTCACTCGTCCGGGCTGTGA","7.40","2.04","24230","MTNKLLLNGRVWNKGDIMGWWKETIDIVKEKDPAARTALEVLLTYPGVKALAAHCLSHFLWTHHCKLLARMHSQFWRFWTQIEIHPGAEIAEGVFIDHGSGLVIGETAIVEKGVMLYHGVTLGGTGKETGKRHPTIRQGALISAHSQVIGPVEVGPGAKVGAGAVVVSDVPADVTVVGVPAKVVRIHGQKDETAIHEIEENREYYLKKLEEAKEASFHSSGL","160775","","serine O-acetyltransferase","Cytoplasm","Similarities in gapped BLAST to serine acetylase sequences. Residues 18-222 are 65% similar to the enzyme from S.pneumoniae (gi15900498). Residues 18-202 are 67% similar to the enzyme from S.pneumoniae (gi15900498).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0205 (1e-71).","

InterPro
IPR001451
Repeat

Bacterial transferase hexapeptide repeat
PF00132	$\"[81-98]T$ $\"[107-124]T$ $\"[151-168]T$	Hexapep

InterPro
IPR005881
Family

Serine O-acetyltransferase
TIGR01172	$\"[21-182]T$	cysE

InterPro
IPR011004
Domain

Trimeric LpxA-like
SSF51161	$\"[20-202]T$	Trimer_LpxA_like

noIPR
unintegrated

unintegrated
G3DSA:1.10.3130.10	$\"[6-82]T$	G3DSA:1.10.3130.10
G3DSA:2.160.10.10	$\"[83-213]T$	G3DSA:2.160.10.10
PTHR23416	$\"[82-184]T$	PTHR23416
PTHR23416:SF2	$\"[82-184]T$	PTHR23416:SF2

","BeTs to 6 clades of COG1045COG name: Serine acetyltransferaseFunctional Class: EThe phylogenetic pattern of COG1045 is ------vcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001451 (Bacterial transferase hexapeptide repeat) with a combined E-value of 6.7e-11. IPB001451 136-171 IPB001451 98-133","Residues 21-50 are 76% similar to a (SERINE TRANSFERASE ACETYLTRANSFERASE) protein domain (PD033521) which is seen in Q9CEI8_LACLA.Residues 54-127 are 90% similar to a (SERINE TRANSFERASE ACETYLTRANSFERASE) protein domain (PD328706) which is seen in Q9CEI8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 17:43:03 2002","Tue Aug 22 13:21:35 2006","Tue Aug 22 13:21:35 2006","Tue Aug 22 13:21:35 2006","Fri Dec 21 14:44:39 2001","Fri Dec 21 14:44:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0140 is paralogously related (blast p-value < 1e-3) to SMu0285, a predicted tetrahydrodipicolinate succinylase.","Fri Dec 21 14:51:44 2001","","No significant hits to the NCBI PDB database.","SMU.157","","No significant hits to the Pfam 11.0 database","Fri Dec 21 14:44:39 2001","24378672","","","Hulanicka MD, Kradich NM.A mutation affecting expression of the gene coding for serine transacetylase in Salmonella typhimurium.Mol Gen Genet. 1976 Oct 18;148(2):143-8.PMID: 790154","","Fri Dec 21 14:55:14 2001","1","","","SMU.157","518" "SMu0141","160852","162195","1344","ATGATAAAAATTTATGACACTTTGACACGCAGTCTGCGTGAATTTGTTCCAATTCATGAAAATACAGTTAATATGTATGTCTGCGGACCAACTGTTTATAATTATATTCATGTAGGCAATGGACGTTCTGCTATCGCTTTTGATACAATTCGCCGCTATTTTGAATACCGTGGATACACTGTCAATTATATTTCCAATTTTACAGATGTTGATGATAAGATCATTAAGGCAGCTGCGAAAGCTGGTATGACTACCAAAGCGTTATCTGATAAGTTTATTGCAGCTTTTAAGGAAGATGTTGCTGCTCTTGGTGTTAAACCTGCGACTGAGAATCCTCGTGTTATTGATTACATGCAGGACATTATTGATTTTGTCCAAATTTTAGTTGACAAAGGCTTTGCTTATGAATCATCAGGAGATGTTTATTTCCGTGTTCGTAAATCTGATAATTATGCTGCTTTGGCCAATAAGACTTTGGAAGAATTAGAGATTGGTGCCAGCGGTCGAGTGGATGCTGAAAGTGATTGCAAAGAAGATCCTTTAGACTTCGCTCTTTGGAAGGCAGCTAAGGAAGGTGAAATTGCTTGGGACAGTCCTTGGGGAGCTGGTCGTCCGGGCTGGCACATTGAATGTTCAGTGATGGCAACAACCATTTTAGGAGATACTATTGATATCCACGGTGGCGGTGCTGACTTAGAATTTCCTCATCATACTAATGAAATTGCTCAATCAGAAGCTAAAACGGGGAAAAAATTTGCCAATTACTGGATGCATAATGGCTTTGTTAATATTGACAATGAGAAAATGTCCAAATCGTTAGGTAATTTTATCACTGTTCACGATGCTCTCAAGACAATGGATGGACAGGTTTTACGTTTCTTCTTTGCAACTCAGCATTATCGTAAGCCTTTTAATTTTACAGAAAAAGCTATTCGTGATGCTGAAATCAACCTTAAATATTTGAAAAATACCTATGAACAGCCTTTTACAGCTACTGTAGATGAGGCTGTATTTGCCAGATTTTTGGAAAAATTTCAAGCAGCTATGGATGAGGACTTCAATACAGCCAATGGCATTACAGTTGTTTTTGAATTGGCTAAATGGATTAATTCAGGTCATTATGATCAAACTGTAAAAGATAAATTTGCAGAAATTCTTCAAATTTTCGGTGTTGTTTTTAAAGAAGAGGTTCTGGATGCTGAGATTGAAAAATTGATTGAGGAACGCCAAAAAGCGCGTGCAGCACGAGATTTTACTAAAGCTGATGCCATTCGTGATGACTTAGCTGCGCAGGGCATCAAGCTTTTGGATACCAAGGATGGTGTGAGGTGGATGCGTGACTAG","5.20","-12.69","50693","MIKIYDTLTRSLREFVPIHENTVNMYVCGPTVYNYIHVGNGRSAIAFDTIRRYFEYRGYTVNYISNFTDVDDKIIKAAAKAGMTTKALSDKFIAAFKEDVAALGVKPATENPRVIDYMQDIIDFVQILVDKGFAYESSGDVYFRVRKSDNYAALANKTLEELEIGASGRVDAESDCKEDPLDFALWKAAKEGEIAWDSPWGAGRPGWHIECSVMATTILGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKKFANYWMHNGFVNIDNEKMSKSLGNFITVHDALKTMDGQVLRFFFATQHYRKPFNFTEKAIRDAEINLKYLKNTYEQPFTATVDEAVFARFLEKFQAAMDEDFNTANGITVVFELAKWINSGHYDQTVKDKFAEILQIFGVVFKEEVLDAEIEKLIEERQKARAARDFTKADAIRDDLAAQGIKLLDTKDGVRWMRD","162192","For other 'cys' genes see SMu0449 (cysK) and SMu1074 (cysD).","cysteinyl-tRNA synthetase","Cytoplasm","Numerous similarities in gapped BLAST to cys-tRNA synthetases. Residues 1-447 are 76% similar to the enzyme from S.pneumoniae (gi|15900500) and 74% similar to the enzyme from S.pyogenes (gi|15675744).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0207 (0.0).","

InterPro
IPR002308
Family

Cysteinyl-tRNA synthetase, class Ia
TIGR00435	$\"[2-447]T$	cysS

InterPro
IPR009080
Domain

Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
SSF47323	$\"[318-396]T$	tRNAsyn_1a_bind

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[19-311]T$	Rossmann-like_a/b/a_fold

InterPro
IPR015273
Domain

Cysteinyl-tRNA synthetase, class Ia, DALR
PF09190	$\"[344-398]T$	DALR_2

InterPro
IPR015803
Domain

Cysteinyl-tRNA synthetase, class Ia, N-terminal
PR00983	$\"[25-36]T$ $\"[61-70]T$ $\"[193-211]T$ $\"[224-245]T$	TRNASYNTHCYS
PF01406	$\"[14-316]T$	tRNA-synt_1e

InterPro
IPR015804
Domain

Cysteinyl-tRNA synthetase, class Ia, C-terminal
PTHR10890	$\"[192-417]T$	Cys_tRNA-synt_1a

noIPR
unintegrated

unintegrated
SSF52374	$\"[1-315]T$	SSF52374

","BeTs to 15 clades of COG0215COG name: Cysteinyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0215 is a--kyqvcebRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001412 (Aminoacyl-transfer RNA synthetases class-I) with a combined E-value of 1.5e-06. IPB001412A 30-40 IPB001412B 265-275","Residues 345-444 are 36% similar to a (LIGASE SYNTHETASE CYSTEINYL-TRNA) protein domain (PD006340) which is seen in Q9I2U7_PSEAE.Residues 258-325 are 61% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000476) which is seen in Q9CEJ0_LACLA.Residues 349-446 are 51% similar to a (SYNTHETASE LIGASE CYSTEINYL-TRNA) protein domain (PD118316) which is seen in SYC_BACHD.Residues 341-446 are 57% similar to a (SYNTHETASE LIGASE CYSTEINYL-TRNA) protein domain (PD403193) which is seen in Q9CEJ0_LACLA.Residues 111-251 are 69% similar to a (SYNTHETASE LIGASE CYSTEINYL-TRNA AMINOACYL-TRNA CYSRS) protein domain (PD186140) which is seen in Q9CEJ0_LACLA.Residues 401-446 are 50% similar to a (SYNTHETASE LIGASE CYSTEINYL-TRNA) protein domain (PD305258) which is seen in Q9RG13_RHOOB.Residues 349-446 are 27% similar to a (SYNTHETASE LIGASE CYSTEINYL-TRNA) protein domain (PD118319) which is seen in SYC_DEIRA.Residues 2-72 are 66% similar to a (SYNTHETASE LIGASE CYSTEINYL-TRNA AMINOACYL-TRNA CYSRS) protein domain (PD118283) which is seen in SYC_BACSU.Residues 252-340 are 30% similar to a (SYNTHETASE PROTEOME COMPLETE) protein domain (PD285370) which is seen in Q9HQL9_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:27:37 2002","Fri Dec 21 14:56:15 2001","Fri Dec 21 14:59:10 2001","Thu Apr 4 15:23:53 2002","Fri Dec 21 14:56:15 2001","Fri Dec 21 14:56:15 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0141 is paralogously related (blast p-value < 1e-3) to SMu1492, a predicted met-tRNA synthetase.","Fri Dec 21 15:00:10 2001","","No significant hits to the NCBI PDB database.","SMU.158","","Residues 14 to 316 (E-value = 1e-186) place SMu0141 in the tRNA-synt_1e family which is described as tRNA synthetases class I (C) catalytic domain (PF01406)","Fri Dec 21 14:56:15 2001","24378673","","","","","","1","","","SMU.158","31" "SMu0142","162188","162607","420","GTGACTAGGTCAGTTGACGTTAATCTTATCAACGGAATCGCCCTTGCTTTTGAGGGGGATGCCATTTATTCTACTTACATTCGGAAACATCTGATTTTTCAAGGTTTGACAAAGCCTAATCAGCTGCATCACAAAACGACTCGTTATGTGTCAGCCAAGGCACAGGCTATGTTGATAACTAAGATGTTAGAAGCGCAGCTTTTGAGCGAAAAAGAAGAAGATATTTACCGTCGCGGACGCAATGCCAACAGCCATACCAAGGCTAAAAATACAGATGTTGTCACATACAAGATGTCAACAGGATTTGAGGCAGTTATGGGTTATCTCCATATGACCGAGCAAATTAAGCGGCTGGAAGAGCTGATTGACTGGTGTATTCAGACAGTTGAAAATGAATATAGTGAATTGAATAAAGGTTAG","8.40","2.15","15952","MTRSVDVNLINGIALAFEGDAIYSTYIRKHLIFQGLTKPNQLHHKTTRYVSAKAQAMLITKMLEAQLLSEKEEDIYRRGRNANSHTKAKNTDVVTYKMSTGFEAVMGYLHMTEQIKRLEELIDWCIQTVENEYSELNKG","162604","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 5-130 are 76% similar to gi|15900501 from S.pneumoniae. Residues 1-132 are 75% similar to gi|15675743 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0208 (2e-52).","

InterPro
IPR000999
Domain

Ribonuclease III
PF00636	$\"[14-114]T$	Ribonuclease_3
SM00535	$\"[2-135]T$	RIBOc

InterPro
IPR008226
Family

Uncharacterised conserved protein UCP005520
PIRSF005520	$\"[4-135]T$	Predicted inactive ribonuclease III homolog

","BeTs to 3 clades of COG1939COG name: Uncharacterized BCRFunctional Class:� SThe phylogenetic pattern of COG1939 is ------vc-b-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 19-129 are 54% similar to a (PROTEOME COMPLETE 5'REGION ATPI) protein domain (PD021504) which is seen in Q9CEJ1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:28:00 2002","Fri Dec 21 15:10:42 2001","Wed Oct 9 08:28:00 2002","Fri Dec 21 15:10:42 2001","","Wed Oct 9 08:28:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0142 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 21 15:10:42 2001","","No significant hits to the NCBI PDB database.","SMU.159","","Residues 5 to 124 (E-value = 3e-82) place SMu0142 in the DUF880 family which is described as Protein of unknown function (DUF880) (PF05948)","Fri Dec 21 15:10:42 2001","24378674","","","","","","1","","","SMU.159","754" "SMu0143","162786","163691","906","ATGACCATTCGTATCATTCACTCAGATAAAATTTACCGTGAGTTGCTGAAAATGCCTGTAGCCAAAAGAAGGGCTTATTTTAAAGAACAAGTTCTGGCGCCTTTTAAGCCCAAATTTTACAAACAGAATATTCCTTACGAGGCAAAGCAGGCGGACGGTTTTGACATCATGATGCTGCTTTCTTGGATGCATCTCATGCCTGAAACGCTGACGGATCAGCACCAAGCCTTCATTGACTGTTTAGATGATGGCTTTTGGAAAAGATGTGACCAAGCCATTCAAGATAGTCTAGCAAGGTTTAGTTCTTTCCAGCTGCCAGTTCAAGATTATACTTTTACAGCTTTATTGGCCAATCCAGCTGCCCCCATGCTGCAAATCAATGATGGTTACAGCGGAGATGGTGGTATTCCAGGTTATATTTTCTTATCTTTGGTGCCCCATTTGGATACCTTAAACCGTGTCCAATCTGCGCTGGCTCACGAGATCAATCATAATGTTCGCTATCAATTTATTGATTGGGACGGTGGTTCTCTGAAGGAGATGATTGTAGCTGAAGGTTTAGCAGAGAATTTCGCTGTACAGCTGTATGGTAAGGAAAAGCTGGGTCCTTGGGTAAGCAAGACAGACTTGGAGACGCTCAATCAGCTGGTTAAGCCTTTCTTACGTGAACATCTTGATGTAAGGGGAATGCAGAAAATCACTGCTTATCTCTATGGCGATAAAATTGCTGCTATGATGGGTCAAGACGGAGTTGGCATGCCTTATTGTGCGGGTTACGCCTGTGGCTATTATCTGGTAAAATACTACTTAGAAAAAACGGGTCAAACAATTGAAGAAGCAACGTTTTTGCCAGCTTCAGAAATCTTAGCGGAGGCGGATGAATTTTGGACAGAGACTACACACTAA","5.30","-8.25","34357","MTIRIIHSDKIYRELLKMPVAKRRAYFKEQVLAPFKPKFYKQNIPYEAKQADGFDIMMLLSWMHLMPETLTDQHQAFIDCLDDGFWKRCDQAIQDSLARFSSFQLPVQDYTFTALLANPAAPMLQINDGYSGDGGIPGYIFLSLVPHLDTLNRVQSALAHEINHNVRYQFIDWDGGSLKEMIVAEGLAENFAVQLYGKEKLGPWVSKTDLETLNQLVKPFLREHLDVRGMQKITAYLYGDKIAAMMGQDGVGMPYCAGYACGYYLVKYYLEKTGQTIEEATFLPASEILAEADEFWTETTH","163688","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins. Residues 3-243 are 42% similar to gi|15925379 from S.aureus. Residues 12-298 are 32% similar to yjfC from Bacillus subtilis (gi|16078278).SMu0143 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006025
Binding_site

Peptidase M, neutral zinc metallopeptidases, zinc-binding site
PS00142	$\"[157-166]?$	ZINC_PROTEASE

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 12-153 are 24% similar to a (PROTEOME COMPLETE) protein domain (PD122811) which is seen in O34458_BACSU.Residues 154-289 are 42% similar to a (PROTEOME COMPLETE YJAZ BH2873) protein domain (PD039362) which is seen in O34458_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:28:20 2002","Fri Dec 21 15:13:52 2001","Wed Oct 9 08:28:20 2002","Fri Dec 21 15:13:52 2001","","Fri Dec 21 15:13:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0143 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:28:20 2002","","No significant hits to the NCBI PDB database.","SMU.160","","No significant hits to the Pfam 11.0 database","Fri Dec 21 15:13:52 2001","24378675","","","","","","1","","","SMU.160","" "SMu0144","163670","164407","738","TTGGACAGAGACTACACACTAAAAGAAATCATGACCATTACTGGTCTAACCAAGCGAACATTGCATTATTACGACCAAATCGGTCTCCTGCCAGCTAGGAAGTTAGCAAATGGCTACCGTCACTATAGTCAGCAGGATTTGATTGATTTGCAGCGCATCCTTTTTCTCAAAGCCTTGGATTTTTCTATTAAAGAAATCCAGTCCTTACTCAAGCTCAGTGATGAGGCTCTGCGTCCGATTTTAGAAGAGCAGCAAACACGCTTGGTTCAGAAAATTCAGGATTTGCAAAAAAAGAAGAAAGAACTGGAAAATTTTCTGGCTGGATCGCCGCTCATTACTTTGGATATTTTTGAAAAACCGTTGAACGACCAATATCAAACAGAAGCAGAGCTTCGTTATGGGAAAACATCGGTCTACCAGACTTATCAAGACCATCGGGCACAGCTTGATTCTACTGAAAGAACTCAGTATGATACAAAAATGGAGCAGCAGTTTGACCAAGTTTTTCAAGAATTTAAACGAGTGAGTCATTTGCCGCTTTCTGCAACAGAAGTAGCGGCAGCTGTTGAACAGTGGAAATCGGCTTTCCTGATGATTGGTGATTTTTCAGATGAGGTTTTGGCTTATATTGCGAAATCTTATGTCTACGATTCGCGTTTTAAACAATATTTTTCTAAATATGGCAATTTTGACCTGACAAGATTTATAGCCGAAGCAGTCACTTATTATTTAACTTAG","6.20","-2.03","28884","MDRDYTLKEIMTITGLTKRTLHYYDQIGLLPARKLANGYRHYSQQDLIDLQRILFLKALDFSIKEIQSLLKLSDEALRPILEEQQTRLVQKIQDLQKKKKELENFLAGSPLITLDIFEKPLNDQYQTEAELRYGKTSVYQTYQDHRAQLDSTERTQYDTKMEQQFDQVFQEFKRVSHLPLSATEVAAAVEQWKSAFLMIGDFSDEVLAYIAKSYVYDSRFKQYFSKYGNFDLTRFIAEAVTYYLT","164404","","transcriptional regulator (MerR family?)","Cytoplasm","Several matches in gapped BLAST to transcriptional regulators. Residues 5-244 are 32% similar to gi|15900634 from S.pneumoniae. Residues 8-243 are 30% similar to gi|16799605 from L.innocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1972 (4e-27).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PF00376	$\"[6-42]T$	MerR
SM00422	$\"[5-73]T$	HTH_MERR
PS50937	$\"[4-72]T$	HTH_MERR_2

InterPro
IPR012925
Domain

TipAS antibiotic-recognition
PF07739	$\"[111-244]T$	TipAS

InterPro
IPR015358
Domain

Transcription regulator MerR, DNA binding
PF09278	$\"[47-105]T$	MerR-DNA-bind

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[5-107]T$	no description

","BeTs to 7 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class:� KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 5e-19. IPB000551A 7-28 IPB000551B 29-70","Residues 43-244 are 29% similar to a (REGULATION TRANSCRIPTION DNA-BINDING) protein domain (PD034841) which is seen in Q9RIN0_STRPN.Residues 5-71 are 34% similar to a (REGULATION TRANSCRIPTION MERCURY MERCURIC) protein domain (PD072158) which is seen in O53082_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:28:52 2002","Fri Dec 21 15:17:30 2001","Fri Dec 21 15:20:13 2001","Fri Dec 21 15:17:30 2001","Fri Dec 21 15:17:30 2001","Fri Dec 21 15:17:30 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0144 is paralogously related (blast p-value < 1e-3) to SMu1630, SMu0477, SMu1918, SMu0663, SMu1868, and SMu0619, all possible transcriptional regulators.","Fri Dec 21 15:20:13 2001","","No significant hits to the NCBI PDB database.","SMU.161","","Residues 6 to 42 (E-value = 9e-06) place SMu0144 in the MerR family which is described as MerR family regulatory protein (PF00376)","Fri Dec 21 15:17:30 2001","24378676","","","","","","1","","","SMU.161","" "SMu0145","165435","164443","993","ATGACAGTAATAACAAACACCCAGCCCTTTATTGGACAACATTGTGAAAGCACAACAATAGGCACCCTGCTTACTCAACTAAGCATTTATCTCAGTGAACCGATGATTTTTGGACTTGGCGAAGGACTAGGGTTTGCTATTTTCAACATGAAAACACTTGATTTCCCTTTTATTGGCGGACGAATTAAACCTGATTTGCTGACAGTGAATTTAAGCAAAAACCTTGGAATAAAGCTAATAACGAACGAAACAAATTCAAAAAATAAAGCTTGGAAAACCGTAAAATCACTGATTGACAACAATAAGGCTGTAGGATTAAAACTAGACTGCTATCATTTGGATTATTTTTCAAATCCTATACATTTTGCTGCTCATCATGTTGCGATGCTTGGCTATGATGATAAAAAGGCTTACCTTGTTGACACCAAACAGCAAGGAACAAAAACTGCAACTTCCCTTGAAAGTCTAGCCTTAGCAAGAAACGAAAAAGGTCCCATGTCATCTCGAAACAAGTATTATATTTTTGAAAAAGAAACTGCTTTGATTCCGATTGAGACAGCTATTTTGAAAGCTGTCCGTCATAATAGCGAAACTTATCTTAACCCTCCTATTAAAAATTTGGGTTACAAAGGAATTGAAAAAGCAAGCAGAGAAATCATCAAATGGTTTAAACAATCTAAAGATATTCAAAAGGAATTTGCAATGTCTGCTCTGCTGATGAAAAGTGCGGGCACTGGCGGAGCGCTCTTTCGTAATTTTTACCGTGACTTTTTGAAGGAAGCCTATGAATGGACTGGACATTCTGCTATCAAAATAGCTTATGAGATTTTTAAAGATAGTGCTAAAAACTGGTCGCGGCTTATTCTTCTATTTGAAAAAGCTGGAAAAACAGGTGATATACAGTATGTTCTAGAAGCTTCTAAGTTATTAAAGGATCTTTCACTGCAGGAAAAAGAGGGTATGCAACTTCTCAATTCAATAAAACAAATGTAA","10.10","12.60","37215","MTVITNTQPFIGQHCESTTIGTLLTQLSIYLSEPMIFGLGEGLGFAIFNMKTLDFPFIGGRIKPDLLTVNLSKNLGIKLITNETNSKNKAWKTVKSLIDNNKAVGLKLDCYHLDYFSNPIHFAAHHVAMLGYDDKKAYLVDTKQQGTKTATSLESLALARNEKGPMSSRNKYYIFEKETALIPIETAILKAVRHNSETYLNPPIKNLGYKGIEKASREIIKWFKQSKDIQKEFAMSALLMKSAGTGGALFRNFYRDFLKEAYEWTGHSAIKIAYEIFKDSAKNWSRLILLFEKAGKTGDIQYVLEASKLLKDLSLQEKEGMQLLNSIKQM","164446","","conserved hypothetical protein","Cytoplasm, Membrane","Residues 14-328 are 26% similar to gi|23137272,an hypothetical protein from Cytophaga hutchinsonii, a bacterium. Residues 11-285 are 26% similar to gi|23573438, an hypothetical protein from Mycobacterium abscessus.SMu0145 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 17:24:51 2002","Mon Oct 28 17:24:51 2002","Mon Oct 28 17:24:51 2002","Fri Dec 21 15:21:16 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0145 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:29:14 2002","","No significant hits to the NCBI PDB database.","SMU.162c","","No significant hits to the Pfam 11.0 database","Fri Dec 21 15:21:16 2001","24378677","","","","","","1","","","SMU.162c","" "SMu0146","166178","165624","555","ATGACTATTTCACTGACCGAACAGTTGATACTTGGTATTTTAGCCGAGGGACCGCAACATGGTTATCACATTGAACAAATTATTAAAGAACGCGACATGCGCAAGTGGACGGATGTTGGTTTCTCATCTATTTATTATACTCTTGATAAACTAGAGAAAAAAAGATTAACCGTCAGTACTGTCAGTAAGGGAAAGGAGAAAAAAGATTATCGAATAACCCAAGAAGGTCGGGAAACTCTAAAGGCAGCTACGCAAAAGCTTATCAGCGAACGCAGACCGGCTAATGCTCACTTAATGACGGGGCTTGCAACAAGTTATCTTTTGAATGACAATGAACTGTGCGCAGCCTTTTCCAAACGAAAAGAAATTCTTGAAAAAGACCTCAAGGACATGCAAAACAAACAGAAAGGTAACCATAACGATACAGCTGTTGCCCAGCAACTTTTCAGCCTTAGCCAAACGCTGCTAAAAGCTGAGAAAGACTGGCTCAATCAGGAATTAAAGAAAATGGGGTTTGCAAAAAGTCAGTATGAAAAGCAGAAAAAGAAAATTTAG","10.30","10.92","21233","MTISLTEQLILGILAEGPQHGYHIEQIIKERDMRKWTDVGFSSIYYTLDKLEKKRLTVSTVSKGKEKKDYRITQEGRETLKAATQKLISERRPANAHLMTGLATSYLLNDNELCAAFSKRKEILEKDLKDMQNKQKGNHNDTAVAQQLFSLSQTLLKAEKDWLNQELKKMGFAKSQYEKQKKKI","165627","","hypothetical protein","Cytoplasm, Extracellular","No significant matches in gapped BLAST. Very weak similarities to conserved hypothetical proteins.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2032 (0.001).","

InterPro
IPR005149
Family

Transcriptional regulator PadR-like
PF03551	$\"[9-83]T$	PadR

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[6-90]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[3-99]T$	SSF46785

","BeTs to 4 clades of COG1695COG name: Predicted transcriptional regulatorsFunctional Class:� KThe phylogenetic pattern of COG1695 is A-Tk--V-ebR----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:29:34 2002","Fri Dec 21 15:22:48 2001","Fri Dec 21 15:23:58 2001","Fri Dec 21 15:22:48 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0146 is paralogously related (blast p-value < 1e-3) to SMu1459, and SMu1552, both conserved hypotheticals.","Fri Dec 21 15:23:58 2001","","No significant hits to the NCBI PDB database.","SMU.163c","","Residues 1 to 83 (E-value = 7.2e-07) place SMu0146 in the PadR family which is described as Transcriptional regulator PadR-like family (PF03551)","Fri Dec 21 15:22:48 2001","24378678","","","","","","1","","","SMU.163c","" "SMu0147","166491","167237","747","ATGAGATATAAAGACTTTACAGAAAATACCGATATTGTCTATGGCGTTCATGCTGTCATAGAAAGCCTTCAGGCTAATACGGGCCATAAACTCTATATCCAAAATGACTTACGTGGTAAAAATGTTGATAAAATAAAGGATCTAGCCGCAGAGAAGAAAGTTCCTATCTCTTGGACGCCCAAGAAAACTTTGTCTGATATGACAAAAGGAGCCGTTCATCAGGGCTTTATCTTACATGTGTCAGCCTTTGCTTATACAGAATTTGAAATGCTTTTAAAAAAAGCAGAGCGAGAAGATAATCCTTTGCTTCTTATCTTAGACGAGCTTAATGATCCTCATAATTTTGGTTCAATTTTGCGTACAGCTGATGCAACCAATGTGACTGGAATTATTATTACCAAACACCGTGCGGTCGGTGTAACACCTGTTGTTGCTAAAACATCAACGGGTGCAGTGGAACATATCCCCATTGCTCGTGTGACCAATCTTGGCCAAGCCCTTGATAAGTTGAAAGCAGCTGGTTTTTGGATTTTTGGGACAGATATGAATGGGACACCTTCAACTCAGTGGAACACTTCTGGGAAGTTAGCTTTGATTATTGGCAATGAAGGACGAGGTATTTCTCACAATATCAAAAAGCAGGTTGATGAAATGGTGACGATTCCTATGAATGGACACGTTCAAAGTCTCAATGCTAGTGTAGCAGCTGCTATTCTCATGTATGAAGTTTTTAGAAATCGAAAGTAA","10.00","6.16","27316","MRYKDFTENTDIVYGVHAVIESLQANTGHKLYIQNDLRGKNVDKIKDLAAEKKVPISWTPKKTLSDMTKGAVHQGFILHVSAFAYTEFEMLLKKAEREDNPLLLILDELNDPHNFGSILRTADATNVTGIIITKHRAVGVTPVVAKTSTGAVEHIPIARVTNLGQALDKLKAAGFWIFGTDMNGTPSTQWNTSGKLALIIGNEGRGISHNIKKQVDEMVTIPMNGHVQSLNASVAAAILMYEVFRNRK","167234","For other 'spo' genes see SMu1964 (spoJ).For other 'trm' genes see SMu1945 (trmU) and SMu0791 (trmD).","tRNA/rRNA methyltransferase","Cytoplasm","Numerous similarities in gapped BLAST to tRNA and RRNA methylases. Residues 1-248 are 80% similar to gi:15675741 from S.pyogenes. Residues 3-247 are 76% similar to gi:15903354 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0209 (1e-112).","

InterPro
IPR001537
Domain

tRNA/rRNA methyltransferase, SpoU
PD001243	$\"[99-231]T$	SpoU_mtfrase
PF00588	$\"[101-241]T$	SpoU_methylase

InterPro
IPR004441
Family

RNA methyltransferase TrmH, group 3
TIGR00186	$\"[9-247]T$	rRNA_methyl_3

InterPro
IPR013123
Domain

RNA 2-O ribose methyltransferase, substrate binding
PF08032	$\"[12-86]T$	SpoU_sub_bind

noIPR
unintegrated

unintegrated
G3DSA:3.40.1280.10	$\"[80-247]T$	G3DSA:3.40.1280.10
PTHR12029	$\"[55-248]T$	PTHR12029
PTHR12029:SF7	$\"[55-248]T$	PTHR12029:SF7
SSF55315	$\"[1-83]T$	SSF55315
SSF75217	$\"[84-248]T$	SSF75217

","BeTs to 14 clades of COG0566COG name: rRNA methylasesFunctional Class: JThe phylogenetic pattern of COG0566 is a---YQvCEBRHujgpOLinxNumber of proteins in this genome belonging to this COG is 2","***** IPB001537 (tRNA/rRNA methyltransferase (SpoU)) with a combined E-value of 1.4e-22. IPB001537A 104-128 IPB001537B 198-206 IPB001537C 229-242","Residues 104-141 are 78% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD403731) which is seen in Q9CEG9_LACLA.Residues 94-240 are 34% similar to a (METHYLTRANSFERASE 2.1.1.- RIBOSE) protein domain (PD149131) which is seen in PT56_YEAST.Residues 150-243 are 35% similar to a (METHYLTRANSFERASE BB0052 PROTEOME) protein domain (PD414506) which is seen in Y052_BORBU.Residues 61-134 are 41% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE RRNA) protein domain (PD016373) which is seen in YJFH_HAEIN.Residues 64-168 are 32% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD415084) which is seen in Y516_BORBU.Residues 146-243 are 31% similar to a (PROTEOME COMPLETE) protein domain (PD414590) which is seen in Q9ZLS7_HELPJ.Residues 146-239 are 38% similar to a (METHYLASE RRNA METHYLTRANSFERASE COMPLETE) protein domain (PD407446) which is seen in Q49000_MYCCA.Residues 11-99 are 55% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD119549) which is seen in Q9CEG9_LACLA.Residues 146-232 are 74% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE RRNA TRNA/RRNA) protein domain (PD001243) which is seen in Q9CEG9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Apr 13 08:49:20 2005","Fri Dec 21 15:24:34 2001","Wed Apr 13 08:49:20 2005","Mon Apr 8 08:42:23 2002","Fri Dec 21 15:24:34 2001","Fri Dec 21 15:24:34 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0147 is paralogously related (blast p-value < 1e-3) to SMu1571, and SMu1555, both predicted RNA methylases.","Fri Dec 21 15:33:44 2001","","No significant hits to the NCBI PDB database.","SMU.164","","Residues 101 to 241 (E-value = 9.7e-51) place SMu0147 in the SpoU_methylase family which is described as SpoU rRNA Methylase family (PF00588)","Fri Dec 21 15:24:34 2001","24378679","","","","","","1","","","SMU.164","246" "SMu0148","167261","168121","861","ATGACTTTTAAAATTTTGACCGATTCAACTGCTGATTTGCCAGAAAGCTGGACACAAGAAAATGATGTCCAAGTGCTTGGTTTAACTGTCCAATTAGATGGTATCACTTATGAAACAGTAGGTCCCGATCGGCTAACAAGCAGGGTGTTGTTAGAAAAAATCGCTGCTGGCAGTAAACCAACGACGAGTCAAGTGAATGTTGGACAGTTTGAATCTTATTTTCGTCAATCCGCTGAAAATGGACAAGAAGTGCTTTACATCGCTTTTTCATCTGTTTTATCAGGAACTTATCAGTCTGCTGTTATGGCTAGAGATATTGTTTTAGAAGAGTATCCACAAGCAAGCATTGAAATTGTTGATACTTTAGCAGCAGCTGGTGGAGAGGGCTACTTAGCAATGCTGGCAGCTCAAGCCCGCGAAGAAGGAAAATCTCTTAAGGAAACCAAAGAATTGATTCTTGATGTAGGACCACGCTTGCGAACTTTCTTCTTAGTGGACAATCTTTACCACTTGATGCGAGGGGGCAGACTCTCAAAGACCTCAGCAATCGTAGGAAGTTTGGTTAATATCAAGCCTCTACTGTGGTTGGATGCCAGTGGGAAATTAGTTCCCATTGCCAAATTACGCGGTCGTAAAAAAGGAATGAAAGAAATGCTTAAACGGGCAACAGCTGATGTGGCTCATGATACGGCTGTTGTGGCCTATGCCAATGATAGTGAAGCTGCTGAAAATTTGAAAGAGCAATTATTGGCAAATGAAAAAATAAAAAATGTAGTCACACTACCTTTAGGCCCTGTCATTTCAACACATGTAGGACCAAATACTTTAGCAGTCTTTACCATCGGTAAAGAAGCCAGATAA","5.90","-2.26","31038","MTFKILTDSTADLPESWTQENDVQVLGLTVQLDGITYETVGPDRLTSRVLLEKIAAGSKPTTSQVNVGQFESYFRQSAENGQEVLYIAFSSVLSGTYQSAVMARDIVLEEYPQASIEIVDTLAAAGGEGYLAMLAAQAREEGKSLKETKELILDVGPRLRTFFLVDNLYHLMRGGRLSKTSAIVGSLVNIKPLLWLDASGKLVPIAKLRGRKKGMKEMLKRATADVAHDTAVVAYANDSEAAENLKEQLLANEKIKNVVTLPLGPVISTHVGPNTLAVFTIGKEAR","168118","","fatty acid-binding protein, DegV family","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-286 are 61% similar to gi15675739 from S.pyogenes and 44% similar to gi15673853 from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0211 (4e-92).","

InterPro
IPR003797
Family

DegV
PF02645	$\"[72-283]T$	DegV
TIGR00762	$\"[3-283]T$	DegV

noIPR
unintegrated

unintegrated
G3DSA:3.30.1180.10	$\"[158-280]T$	G3DSA:3.30.1180.10
G3DSA:3.40.50.10170	$\"[3-155]T$	G3DSA:3.40.50.10170
SSF82549	$\"[1-283]T$	SSF82549

","BeTs to 4 clades of COG1307COG name: Uncharacterized protein, DegV familyFunctional Class: SThe phylogenetic pattern of COG1307 is ------V--Br---GP-----Number of proteins in this genome belonging to this COG is 3","***** IPB003797 (DUF194) with a combined E-value of 6.7e-12. IPB003797A 61-97 IPB003797C 174-196 IPB003797D 262-272","Residues 5-131 are 52% similar to a (PROTEOME COMPLETE PLASMID MG326) protein domain (PD007382) which is seen in Q9CEH0_LACLA.Residues 142-197 are 57% similar to a (PROTEOME COMPLETE BH3627 DEGV) protein domain (PD009439) which is seen in Q9CEH0_LACLA.Residues 200-286 are 29% similar to a (PROTEOME COMPLETE YTEA) protein domain (PD392785) which is seen in Q9CEH0_LACLA.Residues 143-197 are 45% similar to a (PROTEOME COMPLETE DEGV YEJH) protein domain (PD348894) which is seen in DEGV_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 22 13:32:17 2006","Tue Aug 22 13:32:17 2006","Tue Aug 22 13:32:17 2006","Tue Aug 22 13:32:17 2006","Fri Dec 21 15:36:24 2001","Fri Dec 21 15:36:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0148 is paralogously related (blast p-value < 1e-3) to SMu0820, and SMu0533, both conserved hypotheticals.","Fri Dec 21 15:37:23 2001","","No significant hits to the NCBI PDB database.","SMU.165","","Residues 72 to 283 (E-value = 1.7e-71) place SMu0148 in the DUF194 family which is described as Uncharacterized protein, DegV family COG1307 (PF02645)","Fri Dec 21 15:36:24 2001","24378680","","","","","","1","","","SMU.165","519" "SMu0149","168253","168768","516","ATGTTTGACCTTGTTGTTAATTTGATTTTATTGGTTATTGTGATAGGTGGATTTGTCTTCTTAAGATTCTATGCGGATAAGAAAGGCAAGCGAGAATACGATGAACGCCAGTTACTTATGCAAAAGAAAGCTTATACCAATGCGGCTTGGGTTGTTATGGGTTTCAATCTTGTTCTTGTGATATGGGGTGAAGTGTTAGCAAAATATATCTCGCTATCCTTTGCAGGTACTGCCAATCTCTTTCTTATCGTAGGCGTCTTTGTCTGCAGCAGTATCTTAAACGATGCTTATTTCACAGCAGGAAAAAACAAAAAATTCCTCTATGTGTATGCCGTTATTATTGCTGTTCAAATTTTCACTGTTTATCAAAATTGGAGTCAAGGCAGCTTTGGTCATGACGGACATATTTATCTAACAGGAGAAAAAGCAATGAGTTTATTGTTTATCTTGACTTTTGCTGTCATTTTTCTAGTAACTGCTTATAAAACGATTCAGGATAAGAGAGAGGGAAAGTGA","10.20","6.42","19383","MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANLFLIVGVFVCSSILNDAYFTAGKNKKFLYVYAVIIAVQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTAYKTIQDKREGK","168765","","hypothetical protein","Membrane, Cytoplasm","No significant similarities in gapped BLAST.SMu0149 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-16]?$	signal-peptide
tmhmm	$\"[4-24]?$ $\"[46-66]?$ $\"[72-94]?$ $\"[106-126]?$ $\"[145-165]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-43]?$	signal-peptide
tmhmm	$\"[21-43]?$ $\"[49-69]?$ $\"[84-106]?$ $\"[120-140]?$	transmembrane_regions

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[6-60]T$	HTH_3
SM00530	$\"[5-60]T$	HTH_XRE
PS50943	$\"[6-60]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[1-64]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[5-64]T$	G3DSA:1.10.260.40

","BeTs to 4 clades of COG1476COG name: Predicted transcriptional regulatorsFunctional Class:� KThe phylogenetic pattern of COG1476 is Amt------b-----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 6-63 are 51% similar to a (PROTEOME TRANSCRIPTIONAL REGULATOR) protein domain (PD222678) which is seen in Q9KFV7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:32:54 2002","Fri Dec 21 15:49:43 2001","Fri Dec 21 15:51:07 2001","Fri Dec 21 15:49:43 2001","","Fri Dec 21 15:49:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0151 is paralogously related (blast p-value < 1e-3) to SMu0603, SMu1795, SMu0366, and SMu1274, all possible transcriptional regulators.","Fri Dec 21 15:51:07 2001","","No significant hits to the NCBI PDB database.","SMU.168","","Residues 6 to 60 (E-value = 1.8e-17) place SMu0151 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Fri Dec 21 15:49:43 2001","24378683","","","","","","1","","","SMU.168","1029" "SMu0152","169798","170244","447","ATGAACAAAACAACATACATGGCTAAGCCAGGTGAAGTTGAACGTAAATGGTACATTGTTGATGCGACTGATGTCCCTCTTGGACGCCTATCAGCAGTTGTTGCCAGCGTACTTCGCGGTAAAAACAAACCAACATTCACACCTCATACAGACACAGGTGACTTTGTTATTGTTATTAATGCTGAAAAGGTTAAATTAACTGGTAAAAAAGCAGCTAATAAAATCTACTACACTCACTCAATGTATCCAGGTGGATTAAAGCAAATCTCTGCTGGTGAATTGCGTTCTAAAAATGCTGTGCGTTTGATTGAAAAATCTGTTAAAGGGATGCTTCCGCATAACACTCTTGGACGTGCACAAGGTATGAAATTGAAAGTCTTTGTTGGTTCTGAGCATACACATGCTGCACAACAACCAGAAGTACTTGATATTACAGGACTTATCTAA","10.70","11.19","16200","MNKTTYMAKPGEVERKWYIVDATDVPLGRLSAVVASVLRGKNKPTFTPHTDTGDFVIVINAEKVKLTGKKAANKIYYTHSMYPGGLKQISAGELRSKNAVRLIEKSVKGMLPHNTLGRAQGMKLKVFVGSEHTHAAQQPEVLDITGLI","170241","For other 'rpl' genes see SMu0639 (rplT); SMu0771 (rplU); SMu1941 (rplI);SMu0869 (rplJ); SMu0872 (rpl); SMu1175 (rplS); SMu1480 (rplA) and SMu1481 (rplK).","50S ribosomal protein L13","Periplasm, Cytoplasm","Similarities in gapped BLAST are to 50S ribosomal protein L13 sequences. Residues 1-148 are 93% similar to gi|15900228 from S.pneumoniae and 92% similar to gi|15675736 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0214 (3e-79).","

InterPro
IPR005822
Family

Ribosomal protein L13
PD001791	$\"[53-124]T$	Ribosomal_L13
PTHR11545	$\"[1-148]T$	Ribosomal_L13
PF00572	$\"[17-144]T$	Ribosomal_L13
PS00783	$\"[107-129]T$	RIBOSOMAL_L13
SSF52161	$\"[12-144]T$	Ribosomal_L13

InterPro
IPR005823
Family

Ribosomal protein L13, bacterial and organelle form
PTHR11545:SF2	$\"[1-148]T$	Ribosom_L13_bac
TIGR01066	$\"[5-144]T$	rplM_bact

noIPR
unintegrated

unintegrated
G3DSA:3.90.1180.10	$\"[17-147]T$	G3DSA:3.90.1180.10

","BeTs to 17 clades of COG0102COG name: Ribosomal protein L13Functional Class: JThe phylogenetic pattern of COG0102 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001074 (Ribosomal protein L13) with a combined E-value of 1.1e-23. IPB001074A 38-65 IPB001074B 97-112","Residues 117-148 are 90% similar to a (RIBOSOMAL PROTEOME COMPLETE 50S) protein domain (PD371016) which is seen in Q9CDG6_LACLA.Residues 16-116 are 86% similar to a (RIBOSOMAL 50S COMPLETE PROTEOME) protein domain (PD001791) which is seen in Q9CDG6_LACLA.Residues 19-129 are 30% similar to a (RIBOSOMAL 60S L13A 50S) protein domain (PD335764) which is seen in RL13_SULAC.Residues 5-143 are 30% similar to a (CHLOROPLAST RIBOSOMAL 50S L13) protein domain (PD084781) which is seen in RK13_ODOSI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:33:47 2002","Fri Dec 21 15:51:41 2001","Fri Dec 21 15:58:25 2001","Thu Apr 4 13:43:26 2002","Fri Dec 21 15:51:41 2001","Fri Dec 21 15:51:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0152 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 21 15:58:25 2001","","No significant hits to the NCBI PDB database.","SMU.169","","Residues 17 to 144 (E-value = 2.7e-67) place SMu0152 in the Ribosomal_L13 family which is described as Ribosomal protein L13 (PF00572)","Fri Dec 21 15:51:41 2001","24378684","","","Sanchez C, Blanco G, Mendez C, Salas JA.Cloning, sequencing and transcriptional analysis of a Streptomyces coelicolor operon containing the rplM and rpsI genes encoding ribosomal proteins ScoL13 and ScoS9.Mol Gen Genet. 1997 Dec;257(1):91-6.PMID: 943957","","Fri Dec 21 15:58:25 2001","1","","","SMU.169","628" "SMu0153","170269","170661","393","ATGGCACAAGCACAATATGCAGGAACTGGTCGCCGTAAAAACGCTGTCGCACGCGTTCGCTTGGTACCGGGTACTGGTAAAATTACAGTAAACAAAAAAGATGTTGAAGAATATATTCCACATGCTGACCTTCGCCTTGTTATCAACCAACCTTTTGCAGTAACATCTACTGAAGGTTCATATGATGTTTTCGTTAACGTTGTTGGTGGTGGTTATGCAGGTCAATCAGGAGCAATCCGCCACGGAATTGCACGTGCATTGCTTGAGGTTGATCCAGACTTTCGCGACGCACTCAAACGCGCTGGTCTCCTTACACGTGATGCTCGTATGGTTGAACGTAAAAAACCAGGTCTTAAGAAAGCTCGTAAAGCTAGCCAGTTCTCAAAACGTTAA","11.30","13.47","14204","MAQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTEGSYDVFVNVVGGGYAGQSGAIRHGIARALLEVDPDFRDALKRAGLLTRDARMVERKKPGLKKARKASQFSKR","170658","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu1937 (rpsD); SMu0788 (rpsP);SMu1841 (rps10); SMu1838 (rps19);SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).","30S ribosomal protein S9","Cytoplasm, Extracellular","Several matches in gapped BLAST to 30S ribosomal protein S9 sequences. Residues 1-130 are 95% similar to the protein from S.pyogenes (gi|15902316) and 94% to the protein from S.pneumoniae (gi|15900229).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0215 (3e-69).","

InterPro
IPR000754
Domain

Ribosomal protein S9
PD001627	$\"[5-88]T$	Ribosomal_S9
PF00380	$\"[10-130]T$	Ribosomal_S9
PS00360	$\"[69-87]T$	RIBOSOMAL_S9

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[3-130]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
PTHR21569	$\"[1-130]T$	PTHR21569
SSF54211	$\"[4-130]T$	SSF54211

","BeTs to 17 clades of COG0103COG name: Ribosomal protein S9Functional Class: JThe phylogenetic pattern of COG0103 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000754 (Ribosomal protein S9) with a combined E-value of 9.5e-56. IPB000754A 10-32 IPB000754B 51-88 IPB000754C 103-130","Residues 10-130 are 87% similar to a (RIBOSOMAL 30S 40S CHLOROPLAST PROTEOME COMPLETE S9P) protein domain (PD001627) which is seen in Q9CDG7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:34:18 2002","Fri Dec 21 15:59:03 2001","Fri Dec 21 16:05:00 2001","Thu Apr 4 14:50:32 2002","Fri Dec 21 15:59:03 2001","Fri Dec 21 15:59:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0153 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 21 16:05:00 2001","Fri Dec 21 15:59:03 2001","pdb|1FJF|I Chain I, Structure Of The Thermus Thermophilus 30s R... 128 3e-031pdb|1FJF|I Chain I, Structure Of The Thermus Thermophilus 30s R... 224 3e-060","SMU.170","","Residues 10 to 130 (E-value = 7.4e-57) place SMu0153 in the Ribosomal_S9 family which is described as Ribosomal protein S9/S16 (PF00380)","Fri Dec 21 15:59:03 2001","24378685","","","Sanchez C, Blanco G, Mendez C, Salas JA.Cloning, sequencing and transcriptional analysis of a Streptomyces coelicolor operon containing the rplM and rpsI genes encoding ribosomal proteins ScoL13 and ScoS9.Mol Gen Genet. 1997 Dec;257(1):91-6.PMID: 9439573","","Fri Dec 21 16:05:00 2001","1","","","SMU.170","629" "SMu0154","170983","171228","246","ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACAAACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATATCCCTGAATTAACTGTAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGCTCTATTTGAAAGTGTGGGAAATGAACAATGGTAA","4.40","-4.01","9224","MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQW","171225","","conserved hypothetical protein (possible cell growth regulatory protein)","Cytoplasm, Periplasm","Limited weak similarities in gapped BLAST to cell regulatory proteins. Residues 5-81 are 31% similar to a suppressor of inhibitory function of ChpA, PemI-like in E.coli (gi|15803304). Residues 1-81 are 25% similar to a cell growth regulatory protein from Nostoc sp. (gi|17132307).SMu0154 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007159
Domain

SpoVT/AbrB-like, predicted transcription regulator
PF04014	$\"[6-51]T$	SpoVT_AbrB

noIPR
unintegrated

unintegrated
G3DSA:2.10.260.10	$\"[1-81]T$	G3DSA:2.10.260.10
SSF89447	$\"[1-75]T$	SSF89447

InterPro
IPR003477
Family

PemK-like protein
PF02452	$\"[5-108]T$	PemK

InterPro
IPR011067
Family

Plasmid maintenance toxin/Cell growth inhibitor
G3DSA:2.30.30.110	$\"[4-108]T$	CcdB
SSF50118	$\"[4-107]T$	Plasmid_toxin

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 7-78 are 33% similar to a (PROTEOME COMPLETE PLASMID PEMK-LIKE) protein domain (PD290367) which is seen in CHPA_ECOLI.Residues 6-85 are 29% similar to a (PROTEOME COMPLETE CHPA/MAZF INHIBITOR) protein domain (PD290566) which is seen in Q9K6K8_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:35:21 2002","Wed Oct 9 08:35:21 2002","Fri Dec 21 16:19:15 2001","Fri Dec 21 16:15:36 2001","","Fri Dec 21 16:15:36 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0155 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 21 16:19:15 2001","","No significant hits to the NCBI PDB database.","SMU.173","","Residues 5 to 108 (E-value = 1.3e-12) place SMu0155 in the PemK family which is described as PemK-like protein (PF02452)","Fri Dec 21 16:15:36 2001","24378687","","","","","","1","","","SMU.173","" "SMu0156","172543","171752","792","ATGGAATTTACATCTCTTTGGCAAGAATTTGCAAGAATATCAGAGGTTGAAGCAATTGCTCTTGGTGGTTCGCGAGCAACTGGTAATTATGATGAAACATCTGACTATGATCTTTACATTTATTGCTCATCAATTCCTGACGAAGCCACACGATTAACCATATTAAAAAGTTTCTGCTCATATATAGAAATAGGGAATCATTTTTGGGAACTTGAAGACGATTGTACTTTAATGTCTGGTCAAGATATTGATATCCTCTATAGAGACATTAACCAGATAAGAGATGAGCTAGTAGATGTTGTTGAAAGGTGCATCATCCAAAACGCATATACCACCTGTTTATGGCACAATGTTCTGCACTCAAAAATTCTTTATGATTCTGATGATAAGCTAAAGTGTATTGTTAACAGATTTGATATTAACTATCCACAAAAACTAAAACAGACTATCCTTAGCCACCATATGAACTTGTTAACTGGTCATCTTCCATCTTATGATAAGCAAATTATCAAAGCAGTTATGCGTAAAGACATTGTTAGCTTTAATCATAGAGTTACAGCATTTTTAGAAACTTACTTTGATTTAATTTTTGCGCTTAATATGCTAACCCATCCAGGCGAAAAACGAATGATAGCCTATGCCGAACAAAATGCACAGTCTTTACCAAACCATTTTCAAAAGAATATAGAAAGATTAATTTATGGGACAACTTGCCATCCTTACGACATTCAGGATATATTGAATGATATACTCAATGAATTAACACCATTGCTACATGATTCCATAGGATGA","4.90","-13.67","30583","MEFTSLWQEFARISEVEAIALGGSRATGNYDETSDYDLYIYCSSIPDEATRLTILKSFCSYIEIGNHFWELEDDCTLMSGQDIDILYRDINQIRDELVDVVERCIIQNAYTTCLWHNVLHSKILYDSDDKLKCIVNRFDINYPQKLKQTILSHHMNLLTGHLPSYDKQIIKAVMRKDIVSFNHRVTAFLETYFDLIFALNMLTHPGEKRMIAYAEQNAQSLPNHFQKNIERLIYGTTCHPYDIQDILNDILNELTPLLHDSIG","171755","","conserved hypothetical protein","Cytoplasm","Two very weak matches in gapped BLAST to hypotheticals. Residues 5-260 are 21% similar to gi|2811115, an unknown from S.aureus. Residues 8-152 are 23% similar to gi|15667886, an unknown from E.faecalis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1506 (2e-80).","

InterPro
IPR002934
Domain

DNA polymerase, beta-like region
PF01909	$\"[3-107]T$	NTP_transf_2

noIPR
unintegrated

unintegrated
SSF81301	$\"[1-140]T$	SSF81301

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-260 are 21% similar to a (TRANSPOSON ORFX TN5405) protein domain (PD127432) which is seen in O54361_STAIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:35:43 2002","Fri Dec 21 16:22:48 2001","Wed Oct 9 08:35:43 2002","Fri Dec 21 16:22:48 2001","","Fri Dec 21 16:22:48 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0156 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:35:43 2002","","No significant hits to the NCBI PDB database.","SMU.174c","","No significant hits to the Pfam 11.0 database","Fri Dec 21 16:22:48 2001","24378688","","","","","","1","","","SMU.174c","" "SMu0157","172710","172838","129","ATGACAGAAATCCTTAATTTTCTGATTACGGTGTGTGCTGATCGTGAGAATTGGAAAATCAAACACGGTTTGTCTGATAGTGTTCTTTTGATTTTCTTTGCCCGCTTTACAGGAGCCGAATACTGGTAA","5.70","-0.83","4932","MTEILNFLITVCADRENWKIKHGLSDSVLLIFFARFTGAEYW","172835","","hypothetical protein","Membrane, Cytoplasm","No significant match in gapped BLAST.SMu0157 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-39]?$	signal-peptide

InterPro
IPR004501
Domain

Phosphotransferase system, lactose/cellobiose IIC component
PS51105	$\"[1-389]T$	PTS_EIIC_TYPE_3

InterPro
IPR010315
Family

Protein of unknown function DUF915, hydrolase-like
PF06028	$\"[33-271]T$	DUF915

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[44-276]T$	G3DSA:3.40.50.1820
SSF53474	$\"[43-268]T$	SSF53474

InterPro
IPR005025
Domain

NADPH-dependent FMN reductase
PF03358	$\"[1-133]T$	FMN_red

InterPro
IPR014479
Family

NAD(P)H-dependent FMN reductase
PIRSF016214	$\"[1-181]T$	SSUE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[1-187]T$	G3DSA:3.40.50.360
SSF52218	$\"[1-173]T$	SSF52218

","BeTs to 5 clades of COG0431COG name: Predicted flavoproteinFunctional Class: RThe phylogenetic pattern of COG0431 is ----y--cebr---gp-----Number of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 4-131 are 48% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH PHOSPHODIESTERASE) protein domain (PD009603) which is seen in Q9CIJ0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:37:51 2002","Wed Oct 9 08:37:51 2002","Fri Dec 21 16:46:01 2001","Tue Oct 8 08:11:25 2002","","Fri Dec 21 16:43:19 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0161 is paralogously related (blast p-value < 1e-3) to SMu0997, SMu0162, SMu0998, SMu1282, and SMu0112, all conserved hypotheticals except SMu0162, a predicted fumarate reductase.","Fri Dec 21 16:46:01 2001","","No significant hits to the NCBI PDB database.","SMU.179","","Residues 1 to 167 (E-value = 1.3e-21) place SMu0161 in the FMN_red family which is described as NADPH-dependent FMN reductase (PF03358)","Fri Dec 21 16:43:19 2001","24378693","","","Bensing,B.A., Rubens,C.E. and Sullam,P.M.Genetic Loci of Streptococcus mitis That Mediate Binding to HumanPlateletsInfect. Immun. 69 (3), 1373-1380 (2001)PUBMED 11179301","","Fri Dec 21 16:43:19 2001","1","","","SMU.179","" "SMu0162","176037","178448","2412","ATGAAATTAATTGCTATTGTTGGGACCAATGCTAAGCAATCCTATAACCGAATTTTACTGCAATTCATGAAGAGGCATTTTGTTCAAAAGGCTGATATTGACATCATGGAAATTGCTAATGTTCCAATGTTCAATGAAACAGAGGATCAAACGGATTTACCTGCTATCCAAAACTTTAACACTAAAATCAGCCAAGCTGATGGAGTCATTATTGCAACGCCCGAGCACAACCACACCATTCCATCAAGTCTAAACAGCCTTTTGGAATGGCTGTCCTTTAAAGTGCATCCCCTAGATGGCAAACCCCTTATGATCGTTGGGGCTTCTTATGATGTGCAAGGATCTTCTCGAGCGCAATTGCACTTACGGCAGATTTTAGATGCTCCGGGTGTCAATGCGGCCGTCATGCCGGGCAGTGAATTTTTACTGGGACGCGCTCATCAGGCTTTCGACGAAGCAGGCAACCTCAAGTCAGAAGCAACGGTTGATTTTCTAGAGTCTTGCTTCTTTAAATTTTTACGGTTTGTGCAAGTGGCTAATCAATTGAATGAACCAGAAGAAGTAAGCTTTGAAGCAGGGACTTATCAGGTGACAACCCAAGGGCATAATGGCAAATTGCCAATGACTGTAACCTTATCAGAAGAGAAGATTGAAAAGATTGATATTGATAGTTCCGGAGAATCCTCAGGAATAGCCGATATTGTCTTTACACGGATCCCAAATGAAATATTGGAAGGTCAGACTTTGAATGTAGATGCTGTGTCAGGGGCATCGGTGACCAGCAATGGTGTTCTGGACGGGGTTGCCAGAGCAATTAAGCTGGCAGGAGGCAATCCGGATGTTTTGCGGAAACGTCCAAAGGCACCATCAGCCTTGGATAAAGAAGATAAGACTTACAGCACAGATGTGGTTATCGTAGGTGGAGGTGGGGCTGGTTTAGCAGCCGCTGCTCGAGTGCTGCAAGCAGGTAAGCAAGTGATGGTGCTTGAAAAGTTCCCTGCTCTTGGAGGTAATACTGTACGTTCTGGTGGCTTATTAAATGCAGCAGACCCTGAATGGCAAAAGACTTTTCCCGCTAATCCCGGGGAGGCTCATAATCTTTCCGAGCTGATTCAAACAGATGAAGACAGTATTGCAGCAGAATATTTAGCCGACTTTAAGGAATTAAAGCAGCAAGTAACTAATTACTTGAAAGATCCAAGCTATTTATTTGATTCTAATATTCTCCATCGGATTCAAACCTATATTGGTGGTAAAAGAACTGATCGTAATGGTTGTGAAGTCTATGGCAATTATGATCTTGTAAAGGTGTTAACAGATAAGGATCTTGATTCCGTCCATTGGTTAGCGGATATTGGTGTTGATTTTGATCGCTCTGAAGTTAGTATGCCAGTAGGAGCTTTATGGCGTCGCTCTCACAAACCTAAACAACCGATGGGTTATGCTTTTATTGAAGCTTTGGATACCTATATTCGCAAGAATAGTGGTACTATTTTAACGGATACTGCAGTCACAGATTTTATTTTAGAAAATGGTCTTATTAAAGGAGTACTTGCTAAAGGCCGCAATGGACAAACCATTACCGTCCATGCCCAAGCTGTTGTCTTGGCTTCTGGTGGTTTTGGTGCCAATACTAAGATGTTACAACAATATAATACTTATTGGAGTAATATTGATGATAACATTCAAACAACGAATTCACCAGCTATAACAGGTGATGGCATTCGCTTAGGGCAAAGTATTGGTGCCGCTCTTGTTGGTATGGGCTTTAGCCAAATGATGCCAGTGTCAGACCCGAATACGGGAGCCATTTTCTCAGGCTTACAAGTTCCGCCGGCAAACTTTGTTATGGTTAATCAAGAAGGCAAACGTTTTGTGGATGAATATGGTAGCCGTGATACGCTTTCTAAAGCTGCGATTGATAATGGTGGTCTCTTCTATCTAATTGCTGATGAAAATATCAAAGCAACTGCCATGAATACCAGCAATGAAAAAATTGAAGAACAAGTTGCAGCAGGAACGCTTTATCGTGCTGATACTTTAGAAAGTTTGGCAGAGCAAATTGGTGTGGATCCCGCTACCCTTGTGGAAACCATCAACAATTACAATTCCTATGTTGAAGCGGGCTATGATCCTGAGTTTGATAAAGGAGCTTTTGATCTCAAGGTTGAAAAGGCGCCATTTTATGCAACACCTCGAAAACCAGCAACCCATCATACGATGGGCGGTTTGAAGATTGATACACAAGCTCATGTTATTAAAGAAGATGGCAATAAGATTCCATCTCTTTACGCTGCTGGGGAAGTGACAGGCGGCATTCACGCAGGCAATCGCTTAGGCGGTAATGCTTTAGCTGATATCTTTACTTTTGGACGTATTGCAGCAGAAACAGCTGTAACAGAATGCTGCTAA","4.90","-25.26","86803","MKLIAIVGTNAKQSYNRILLQFMKRHFVQKADIDIMEIANVPMFNETEDQTDLPAIQNFNTKISQADGVIIATPEHNHTIPSSLNSLLEWLSFKVHPLDGKPLMIVGASYDVQGSSRAQLHLRQILDAPGVNAAVMPGSEFLLGRAHQAFDEAGNLKSEATVDFLESCFFKFLRFVQVANQLNEPEEVSFEAGTYQVTTQGHNGKLPMTVTLSEEKIEKIDIDSSGESSGIADIVFTRIPNEILEGQTLNVDAVSGASVTSNGVLDGVARAIKLAGGNPDVLRKRPKAPSALDKEDKTYSTDVVIVGGGGAGLAAAARVLQAGKQVMVLEKFPALGGNTVRSGGLLNAADPEWQKTFPANPGEAHNLSELIQTDEDSIAAEYLADFKELKQQVTNYLKDPSYLFDSNILHRIQTYIGGKRTDRNGCEVYGNYDLVKVLTDKDLDSVHWLADIGVDFDRSEVSMPVGALWRRSHKPKQPMGYAFIEALDTYIRKNSGTILTDTAVTDFILENGLIKGVLAKGRNGQTITVHAQAVVLASGGFGANTKMLQQYNTYWSNIDDNIQTTNSPAITGDGIRLGQSIGAALVGMGFSQMMPVSDPNTGAIFSGLQVPPANFVMVNQEGKRFVDEYGSRDTLSKAAIDNGGLFYLIADENIKATAMNTSNEKIEEQVAAGTLYRADTLESLAEQIGVDPATLVETINNYNSYVEAGYDPEFDKGAFDLKVEKAPFYATPRKPATHHTMGGLKIDTQAHVIKEDGNKIPSLYAAGEVTGGIHAGNRLGGNALADIFTFGRIAAETAVTECC","178445","","oxidoreductase, possible fumarate reductase","Cytoplasm, Extracellular","Mixed similarities to oxidoreductases, conserved hypotheticals and Chain A, flavocytochrome C3 sequences. Residues 1-191 are 54% similar to gi|15901322, a predicted oxidoreductase in S.pyogenes and also 54% similar to gi|15903369, an unknown from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1083 (7e-61).","

InterPro
IPR000759
Family

Adrenodoxin reductase
PR00419	$\"[302-324]T$ $\"[325-338]T$	ADXRDTASE

InterPro
IPR001613
Family

Flavin-containing amine oxidase
PR00757	$\"[302-321]T$ $\"[765-782]T$	AMINEOXDASEF

InterPro
IPR003953
Domain

Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal
PF00890	$\"[302-784]T$	FAD_binding_2

InterPro
IPR005025
Domain

NADPH-dependent FMN reductase
PF03358	$\"[1-167]T$	FMN_red

InterPro
IPR007329
Domain

FMN-binding
PF04205	$\"[201-275]T$	FMN_bind

InterPro
IPR010960
Family

Flavocytochrome c
TIGR01813	$\"[302-796]T$	flavo_cyto_c

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[1-187]T$	G3DSA:3.40.50.360
G3DSA:3.50.50.60	$\"[296-800]T$	G3DSA:3.50.50.60
PTHR11632	$\"[301-390]T$ $\"[433-542]T$ $\"[559-662]T$ $\"[705-798]T$	PTHR11632
PTHR11632:SF3	$\"[301-390]T$ $\"[433-542]T$ $\"[559-662]T$ $\"[705-798]T$	PTHR11632:SF3
SSF51905	$\"[280-800]T$	SSF51905
SSF52218	$\"[1-173]T$	SSF52218
SSF56425	$\"[590-740]T$	SSF56425

","BeTs to 10 clades of COG1053COG name: Succinate dehydrogenase/fumarate reductase, flavoprotein subunitsFunctional Class: CThe phylogenetic pattern of COG1053 is Amt-YqvcEbRhuj----inxNumber of proteins in this genome belonging to this COG is 2","***** IPB003952 (Fumarate reductase / succinate dehydrogenase FAD-binding site) with a combined E-value of 8.4e-17. IPB003952A 302-316 IPB003952F 571-621 IPB003952H 761-792***** IPB000447 (FAD-dependent glycerol-3-phosphate dehydrogenase) with a combined E-value of 9.5e-09. IPB000447A 301-353 IPB000447C 523-545***** IPB000171 (Bacterial-type phytoene dehydrogenase) with a combined E-value of 2.8e-08. IPB000171A 304-334***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 6.4e-08. PR00368A 302-324 PR00368E 763-770***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 5.5e-06. IPB000103A 302-322 IPB000103A 303-323 IPB000103C 268-316***** PR00420 (Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature) with a combined E-value of 6.3e-06. PR00420A 302-324 PR00420D 537-553","Residues 735-798 are 37% similar to a (FLAVOPROTEIN SUBUNIT OXIDOREDUCTASE FAD DEHYDROGENASE) protein domain (PD001219) which is seen in Q9CGH2_LACLA.Residues 2-131 are 49% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH PHOSPHODIESTERASE) protein domain (PD009603) which is seen in Q9CIJ0_LACLA.Residues 480-798 are 25% similar to a (PLASMID) protein domain (PD139700) which is seen in Q9L5J6_SALTI.Residues 675-730 are 39% similar to a (FLAVOPROTEIN SUBUNIT REDUCTASE FUMARATE) protein domain (PD129803) which is seen in FRD2_SHEFR.Residues 462-628 are 30% similar to a (OXIDOREDUCTASE 1-DEHYDROGENASE FAD) protein domain (PD008718) which is seen in P71864_MYCTU.Residues 488-735 are 26% similar to a (C SUBUNIT FLAVOCYTOCHROME FLAVIN) protein domain (PD062665) which is seen in P96182_WOLSU.Residues 681-790 are 36% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD009971) which is seen in Q9I1M6_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:38:13 2002","Fri Dec 21 16:52:08 2001","Fri Dec 21 16:52:08 2001","Tue Oct 8 08:11:55 2002","Fri Dec 21 16:47:41 2001","Fri Dec 21 16:47:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0162 is paralogously related (blast p-value < 1e-3) to SMu0998, SMu1282, SMu0997, SMu0161, SMu1286, SMu0112, SMu0116, and SMu0331, all conserved hypotheticals or possible reductases.","Fri Dec 21 16:53:33 2001","Fri Dec 21 16:47:41 2001","pdb|1E39|A Chain A, Flavocytochrome C3 From Shewanella Frigidim... 209 1e-054pdb|1QJD|A Chain A, Flavocytochrome C3 From Shewanella Frigidim... 208 2e-054pdb|1D4C|A Chain A, Crystal Structure Of The Uncomplexed Form O... 206 6e-054","SMU.180","","Residues 1 to 167 (E-value = 9.3e-16) place SMu0162 in the FMN_red family which is described as NADPH-dependent FMN reductase (PF03358)Residues 195 to 275 (E-value = 4.3e-22) place SMu0162 in the FMN_bind family which is described as FMN-binding domain (PF04205)Residues 471 to 801 (E-value = 2.2e-14) place SMu0162 in the FAD_binding_2 family which is described as FAD binding domain (PF00890)","Fri Dec 21 16:47:41 2001","24378694","","","","","","1","","","SMU.180","" "SMu0163","178654","179652","999","ATGATTGATTCTCAATTAAAGGAAAAAAGAAAAGTCATTATTGAAAAGAAGATTGCTTTGGGCAAAGCTTCTGGGAAAATTATTTTAATGGGGGAGCATGCTGTCGTTTATGGACAGCCAGCCATTGCTATCCCTTTTTCTGCTGTTGAGACTGTGGCAGAAGTTAAAGAAGACGGCGAAGCCTTAACAGTTACCTGCGAATTTTATGACGGTCTTGTTCATAAGATGCCTGAAATTTTGGAAAGTCTCAAGCATGCCATTCGTTTTTCCCTTTATCGTATTGGAGCACCGCAAGATCCAGCCATTCATATTGATATTCACTCTACCATTCCTGCTGAACGTGGAATGGGGTCAAGTGCAGCGGTGGCTGTAGCTATTGCTAGAAGTCTTTTTAACTTTTATGGTAAGGTATTGACGGATAAGGAATTATGGGAAATTGTTCAATCATCAGAAAAGATTGCACACGGTAATCCTTCTGGGATTGATACCGTAACGACTAGTGGCAAATCTCCAGTTTTTTTTGTTAAAGATCAGCCCATTGAACAGTTGTCAATCAATATGGATGCCTATTTGATTGTTGCTGATACCGGTCAGACTGGGCAGACCTTAAAAGCTATTCAATCGGTAAAAGCACTTCTTAGCAAAGTAACTTATCAAATTGATAGCCTTTCAGATCCTAAGCAAGCCATTAAGGAATTAGGTCAATTGACAAAATTGGCAAAGGAAGCTCTATTAAATAATTACATTTTAGAATTAGGCGAAGTGATGAATCAGGCCCACCAACTTTTAGCAAGTCTAACGGTTTCCAATCAAACTTTGGACAGACTGGCTCAAGCTGCTAGACAAGCAGGAGCTTTAGGAGCTAAATTAACAGGTGGTGGCCGAGGTGGATGCCTCATTGCTCTTGCGAAAGATAAAGAAAGTGCAGAAAAGATTGCAAGATCCTTATTAGAACAAGGTGCTAAGCAAGCATGGTGCCAATATTTAGGAAATCTCTAA","7.60","1.56","35748","MIDSQLKEKRKVIIEKKIALGKASGKIILMGEHAVVYGQPAIAIPFSAVETVAEVKEDGEALTVTCEFYDGLVHKMPEILESLKHAIRFSLYRIGAPQDPAIHIDIHSTIPAERGMGSSAAVAVAIARSLFNFYGKVLTDKELWEIVQSSEKIAHGNPSGIDTVTTSGKSPVFFVKDQPIEQLSINMDAYLIVADTGQTGQTLKAIQSVKALLSKVTYQIDSLSDPKQAIKELGQLTKLAKEALLNNYILELGEVMNQAHQLLASLTVSNQTLDRLAQAARQAGALGAKLTGGGRGGCLIALAKDKESAEKIARSLLEQGAKQAWCQYLGNL","179649","For other 'mva' genes see SMu0850 (mvaD); SMu0851 (mvaK2) and SMu0855 (mvaA).","mevalonate kinase","Cytoplasm","Similarities in gapped BLAST to mevolonate kinases. Residues 20-389 are 38% similar to the enzyme from E.faecalis (gi|9937386). Residues 21-330 are 31% similar to the enzyme from S.aureus (gi|9937364).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1326 (2e-34).","

InterPro
IPR006204
Domain

GHMP kinase
PF00288	$\"[103-169]T$	GHMP_kinases_N

InterPro
IPR006205
Family

Mevalonate kinase
PIRSF500058	$\"[18-329]T$	MVK
PTHR10457:SF4	$\"[75-312]T$	Mev_gal_kin
TIGR00549	$\"[23-302]T$	mevalon_kin

InterPro
IPR006206
Family

Mevalonate and galactokinase
PR00959	$\"[23-47]T$ $\"[108-130]T$ $\"[151-170]T$ $\"[287-304]T$	MEVGALKINASE

InterPro
IPR012197
Family

Mevalonate kinase/phosphomevalonate kinase
PIRSF000546	$\"[18-332]T$	MVK_PMK

InterPro
IPR013750
Domain

GHMP kinase, C-terminal
PF08544	$\"[240-322]T$	GHMP_kinases_C

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[14-202]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.890	$\"[237-314]T$	G3DSA:3.30.70.890
PTHR10457	$\"[75-312]T$	PTHR10457
SSF54211	$\"[18-203]T$	SSF54211
SSF55060	$\"[178-330]T$	SSF55060

","BeTs to 6 clades of COG1577COG name: Mevalonate kinaseFunctional Class: IThe phylogenetic pattern of COG1577 is amtky-----------o----Number of proteins in this genome belonging to this COG is 2","***** PR00959 (Mevalonate kinase signature) with a combined E-value of 1e-26. PR00959A 23-47 PR00959B 108-130 PR00959C 151-170 PR00959D 287-304***** IPB001745 (GHMP kinases putative ATP-binding domain) with a combined E-value of 1.7e-20. IPB001745A 24-33 IPB001745B 110-121 IPB001745C 151-160 IPB001745D 287-298***** PR00960 (LmbP protein signature) with a combined E-value of 7.5e-09. PR00960B 109-130 PR00960E 281-300***** IPB000705 (Galactokinase) with a combined E-value of 3.1e-07. IPB000705A 23-46 IPB000705C 101-122 IPB000705H 287-298","Residues 181-274 are 39% similar to a (KINASE GALACTOSE GALACTOKINASE) protein domain (PD002375) which is seen in Q9FD64_ENTFC.Residues 20-173 are 46% similar to a (KINASE MEVALONATE PROTEOME COMPLETE) protein domain (PD261044) which is seen in Q9FD69_ENTFA.Residues 191-320 are 30% similar to a (KINASE MEVALONATE TRANSFERASE MK) protein domain (PD124425) which is seen in Q9FD69_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 17:45:57 2002","Fri Dec 21 16:54:47 2001","Tue Oct 22 17:41:10 2002","Mon Apr 8 08:51:12 2002","Fri Dec 21 16:54:47 2001","Fri Dec 21 16:54:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0163 is paralogously related (blast p-value < 1e-3) to SMu0808, a predicted galactokinase.","Fri Dec 21 17:02:35 2001","","No significant hits to the NCBI PDB database.","SMU.181","","Residues 101 to 305 (E-value = 7.4e-38) place SMu0163 in the GHMP_kinases family which is described as GHMP kinases putative ATP-binding protein (PF00288)","Fri Dec 21 16:54:47 2001","24378695","","","Wilding,E.I., Brown,J.R., Bryant,A.P., Chalker,A.F., Holmes,D.J.,Ingraham,K.A., Iordanescu,S., So,C.Y., Rosenberg,M. and Gwynn,M.N.Identification, evolution, and essentiality of the mevalonatepathway for isopentenyl diphosphate biosynthesis in gram-positivecocciJ. Bacteriol. 182 (15), 4319-4327 (2000)PubMed: 10894743","","Mon Apr 8 08:51:12 2002","1","","","SMU.181","821" "SMu0164","179874","180596","723","ATGTTAAAGATAGAAAATTTAAGCGTTTCTTATCGTGATCATCTTGCTTTAGAGAATGTTTCCTTGGAAATCCCTAGTTCAACAATTACAGGTATTATTGGCCCCAATGGTGCGGGCAAGTCAACCTTATTTAAAGGGGTTCTTAATATGGTCGATCATGAAGGGACAAGTTTTATTGATGGCAAAATCTTAAGTCAAAATCTAGGAAGTATTTCCTATGTTGAACAAAAAGCGGATATTGATTACAATTTTCCCATTAAAGTCAAGGAATGCGTTTCTTTAGGTTTATTTTCAAAAGTCAAACCTTTTTCAAATTTGAAAAAACAAGATTGGCAATGTGTTCAAGAAGCACTTTCTCAGGTTGATTTGGCAGACTATGCCAATAGGCAGATTAGTCAACTTTCAGGGGGGCAATTTCAACGTATGCTCTTGGCTCGTTGTTTGGTACAAGATGCTGATTATATTTTTTTAGATGAACCTTTTGTAGGAATTGATATTATCAGTGAGGAACTGATTGTAGGACTGTTACAAAAGCTCAAGAAAGAAGGAAAGACCATTTTAATCATTCATCATGACTTGAGTAAGGTCAAAACTTACTTTGATCACGTTCTGCTTTTGAACAAAAAAGTCCTTGCCTTCGGTCAGACAGAAACTGTTTTTACACAGAAAAATCTGACTAAAACCTATCAATCACAATTTTTAATGGCAGGTGATGCTTCATGA","6.70","-0.94","26778","MLKIENLSVSYRDHLALENVSLEIPSSTITGIIGPNGAGKSTLFKGVLNMVDHEGTSFIDGKILSQNLGSISYVEQKADIDYNFPIKVKECVSLGLFSKVKPFSNLKKQDWQCVQEALSQVDLADYANRQISQLSGGQFQRMLLARCLVQDADYIFLDEPFVGIDIISEELIVGLLQKLKKEGKTILIIHHDLSKVKTYFDHVLLLNKKVLAFGQTETVFTQKNLTKTYQSQFLMAGDAS","180593","For other components see SMu0165 (MSD1) and SMu0166 (SBP1). For other 'slo' genes see SMu0165 (sloB); SMu0166 (sloC); SMu0168 (sloR) and SMu1189 (sloC).","ABC transporter, ATP-binding protein, iron and/or manganese","Cytoplasm, Membrane","This sequence was previously published in GenBank as gi|8925937, a predicted ABC transporter element. Additional similarities are to ABC transporters, many of which are concerned with manganese. Residues 1-239 are 65% similar to gi|7445846 from S.gordonii.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1532 (2e-70).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[133-176]T$	ABC_transporter
PF00005	$\"[27-209]T$	ABC_tran
PS00211	$\"[134-148]T$	ABC_TRANSPORTER_1
PS50893	$\"[2-233]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-211]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-230]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-230]T$	PTHR19222
PTHR19222:SF31	$\"[2-230]T$	PTHR19222:SF31
SSF52540	$\"[1-229]T$	SSF52540

","BeTs to 11 clades of COG1121COG name: ABC-type iron (III) transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1121 is a-tk-qvCeB-H-----LINxNumber of proteins in this genome belonging to this COG is 2","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.1e-23. IPB001140A 16-62 IPB001140B 131-169 IPB001140C 185-214","Residues 179-217 are 64% similar to a (ATP-BINDING TRANSPORTER COMPLETE PROTEOME) protein domain (PD000174) which is seen in Y339_CHLMU.Residues 179-229 are 49% similar to a (ATP-BINDING ZINC TRANSPORT SYSTEM) protein domain (PD390810) which is seen in TROB_TREPA.Residues 177-217 are identical to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD027309) which is seen in Q9KIJ5_STRMU.Residues 71-131 are 39% similar to a (ATP-BINDING TRANSPORT IRON ABC) protein domain (PD330862) which is seen in YCXD_CYAPA.Residues 70-129 are identical to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD001985) which is seen in Q9KIJ5_STRMU.Residues 1-51 are 41% similar to a (TRANSPORT ATP-BINDING IRON CHELATIN) protein domain (PD351726) which is seen in Y888_HELPY.Residues 17-64 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9KIJ5_STRMU.Residues 133-176 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9KIJ5_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 3 14:21:41 2003","Fri Jan 3 14:21:41 2003","Tue Oct 29 09:48:01 2002","Mon Apr 8 11:19:53 2002","Wed Jan 2 13:58:03 2002","Wed Jan 2 13:58:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0164 is paralogously related (blast p-value < 1e-3) to SMu0907, SMu0849, SMu1811, SMu0390, SMu0235, SMu0216, SMu0976, SMu1950, SMu1003, SMu1920, SMu0418, SMu0335, SMu1949, SMu1517, SMu1428, SMu0596, SMu0517, SMu1757, SMu0218, SMu1036, SMu1518, SMu1065, SMu1079, SMu1762, SMu0884, SMu0374, SMu1410, SMu0731, SMu0594, SMu1545, SMu0950, SMu1380, SMu0971, SMu0944, SMu0805, SMu1288, SMu1037, SMu1023, SMu1093, SMu0786, SMu0666, SMu1959, SMu1649, SMu0752, SMu1064, SMu0258, SMu1306, SMu0825, SMu0823, SMu1068, SMu1710, SMu0986, SMu1751, SMu0475, SMu0729, SMu0916, SMu0234, SMu0987, SMu0476, SMu1724, SMu1001, SMu1246, SMu1231, SMu0224, SMu1210, SMu0024, SMu0836, SMu1202, SMu1686, SMu1316, SMu0837, SMu0824, and SMu1050, all having ATP-binding capabilities.","Mon Apr 8 11:19:53 2002","Wed Jan 2 13:58:03 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 73 4e-014pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 70 2e-013","SMU.182","","Residues 27 to 209 (E-value = 1.3e-39) place SMu0164 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Jan 2 13:58:03 2002","24378696","","Kitten,T., Munro,C.L., Michalek,S.M. and Macrina,F.L.Genetic characterization of a streptococcus mutans LraI familyoperon and role in virulenceInfect. Immun. 68 (8), 4441-4451 (2000)PubMed: 10899841","","Mon Apr 8 11:20:17 2002","","1","","","SMU.182","" "SMu0165","180593","181432","840","ATGATTACAGAATTTATACAAGGCTTATATCAGTTTCATTTTTTACAAAATGCCTTGGTTACGGCGATTGTTATTGGTATCGTAGCAGGAGCTGTAGGCTGTTTTATCATTCTTCGTGGAATGTCCCTTATGGGGGATGCCATTTCTCATGCTGTTTTGCCGGGCGTTGCCTTATCTTATATTTTGGGAATTAATTTTTTTATTGGAGCTATTGTTTTTGGTCTTTTGGCTTCGCTCATTATCACCTTTATTAAGGAAAACAGCATCATTAAAAGCGATACAGCTATAGGGATAACCTTTAGTTCTTTCTTGGCGCTGGGTGTCATTTTGATTGGTCTTGCCAATAGTTCAACTGATTTATTTCATATTTTGTTTGGTAATATCTTGGCTGTTCAGGATATGGATAAGTGGATTACTGTGGGCATTTCTTTGCTTGTTCTTCTTTTTATCTGTTTATTTTTCAGACCGCTTTTATTGACCTCTTTTGATCCTGTTTTGGCTAAATCTATGGGGCTGTCTGTTCATTTTTACCATTATCTGTTGATGATTCTATTGACTCTGGTTTCTGTTACAGCTATGCAGAGTGTTGGTACGATTTTAATTGTTGCCTTGCTCATTACTCCAGCAGCGACAGCTTACCTTTATGCCAATAGCTTAAAAACCATGATTTTATTATCGTCAACTTTAGGTGCTTTTGCTTCCGTTGCCGGGCTCTTTATCGGCTATAGTTTTAATATTGCAGCGGGTTCAAGCATTGTCTTAACCTCAGCACTTATCTTTTTGATTTCTTTTGTTTTTGCACCCAAGCAAAGATTTTTTAAGAAAAAAGCAAAAAAATAA","10.20","7.09","29965","MITEFIQGLYQFHFLQNALVTAIVIGIVAGAVGCFIILRGMSLMGDAISHAVLPGVALSYILGINFFIGAIVFGLLASLIITFIKENSIIKSDTAIGITFSSFLALGVILIGLANSSTDLFHILFGNILAVQDMDKWITVGISLLVLLFICLFFRPLLLTSFDPVLAKSMGLSVHFYHYLLMILLTLVSVTAMQSVGTILIVALLITPAATAYLYANSLKTMILLSSTLGAFASVAGLFIGYSFNIAAGSSIVLTSALIFLISFVFAPKQRFFKKKAKK","181429","For other components see SMu0164 (NBD1) and SMu0166 (SBP1).For other 'slo' genes see SMu0164 (sloA); SMu0166 (sloC); SMu0168 (sloR) and SMu1189 (sloC).","manganese ABC transporter permease element","Membrane, Cytoplasm","This sequence was previously published in GenBank as gi8925938. In addition, residues 1-264 are 81% similar to gi1171961 from S.gordonii.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1531 (1e-110).","

InterPro
IPR001626
Family

ABC-3
PF00950	$\"[11-267]T$	ABC-3

noIPR
unintegrated

unintegrated
SSF81345	$\"[4-261]T$	SSF81345

","BeTs to 11 clades of COG1108COG name: ABC-type Mn/Zn transport systems, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1108 is a-tk-QvCeB-H-----LINxNumber of proteins in this genome belonging to this COG is 2","***** IPB001626 (ABC 3 transport family) with a combined E-value of 4e-108. IPB001626A 25-71 IPB001626B 78-112 IPB001626C 119-136 IPB001626D 186-231 IPB001626E 232-264","Residues 166-265 are identical to a (MEMBRANE TRANSPORT PROTEOME COMPLETE) protein domain (PD002769) which is seen in Q9KIJ4_STRMU.Residues 34-162 are 99% similar to a (TRANSPORT MEMBRANE TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD186109) which is seen in Q9KIJ4_STRMU.Residues 171-265 are 31% similar to a (ZINC TRANSPORT SYSTEM TROC) protein domain (PD107828) which is seen in TROC_TREPA.Residues 179-262 are 29% similar to a (TRANSPORT MEMBRANE METAL INNER) protein domain (PD346276) which is seen in Q9K4V5_STAXY.Residues 154-265 are 35% similar to a (PROTEOME COMPLETE PERMEASE TRANSMEMBRANE) protein domain (PD401101) which is seen in Q9XDA5_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 8 14:05:08 2007","Thu Mar 8 14:05:08 2007","Thu Mar 8 14:05:08 2007","Mon Apr 8 11:21:04 2002","Wed Jan 2 13:59:05 2002","Wed Jan 2 13:59:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0165 is paralogously related (blast p-value < 1e-3) to SMu1810, and SMu0905, both ABC transporter permeases.","Wed Jan 2 14:03:28 2002","","No significant hits to the NCBI PDB database.","SMU.183","","Residues 11 to 267 (E-value = 2.5e-132) place SMu0165 in the ABC-3 family which is described as ABC 3 transport family (PF00950)","Wed Jan 2 13:59:05 2002","24378697","","Kitten,T., Munro,C.L., Michalek,S.M. and Macrina,F.L.Genetic characterization of a streptococcus mutans LraI familyoperon and role in virulenceInfect. Immun. 68 (8), 4441-4451 (2000)PubMed: 10899841","","Mon Apr 8 11:21:31 2002","","1","","","SMU.183","" "SMu0166","181479","182399","921","ATGAAGAAATTAAGCTTATTATTACTAGTTTGTTTATCTTTATTAGGCTTATTTGCCTGTACTTCTAAAAAAACAGCCGACAAAAAATTGACTGTTGTGGCTACCAATTCTATTATTGCTGATATTACTAAGAATATCGCTGGTAATAAGGTTGTCTTACATAGTATCGTTCCTGTTGGTCGAGATCCTCACGAATATGAGCCTCTTCCTGAAGATGTTAAAAAGACCTCTCAGGCTGATGTCATTTTTTATAATGGGATTAATCTTGAAAATGGAGGCAATGCTTGGTTTACCAAACTAGTTAAAAATGCTCATAAAAAGACAGACAAGGATTATTTTGCAGTGAGCGATAGTGTTAAGACCATTTATTTGGAAAATGCAAAAGAAAAAGGAAAGGAAGATCCTCATGCTTGGCTTGACCTTAAAAATGGTATTATTTATGCTAAAAATATCATGAAACGTCTATCTGAAAAAGATCCTAAAAACAAGAGTTATTATCAGAAAAATTTTCAAGCCTACAGCGCCAAACTTGAAAAACTACACAAAGTAGCCAAAGAAAAAATCAGTCGTATCCCTACTGAGAAGAAAATGATCGTAACTAGTGAAGGTTGTTTCAAGTATTTCTCTAAGGCTTACGATATTCCTTCTGCCTATATATGGGAAATTAATACCGAAGAAGAGGGAACACCAAATCAAATTAAGGCTTTAGTGAAAAAATTAAGGAAAAGTCGGGTGTCTGCGCTTTTTGTAGAAAGCAGTGTTGATGATCGTCCAATGAAAACTGTTTCAAAAGATACAGGTATCCCAATTGCCGCTAAAATTTTTACAGATTCAGTTGCTAAAAAAGGACAGGCTGGAGATAGTTACTATGCGATGATGAAGTGGAATATAGATAAAATTGCAAATGGTCTGTCACAATGA","10.30","18.07","34351","MKKLSLLLLVCLSLLGLFACTSKKTADKKLTVVATNSIIADITKNIAGNKVVLHSIVPVGRDPHEYEPLPEDVKKTSQADVIFYNGINLENGGNAWFTKLVKNAHKKTDKDYFAVSDSVKTIYLENAKEKGKEDPHAWLDLKNGIIYAKNIMKRLSEKDPKNKSYYQKNFQAYSAKLEKLHKVAKEKISRIPTEKKMIVTSEGCFKYFSKAYDIPSAYIWEINTEEEGTPNQIKALVKKLRKSRVSALFVESSVDDRPMKTVSKDTGIPIAAKIFTDSVAKKGQAGDSYYAMMKWNIDKIANGLSQ","182396","For other components see SMu0164 (NBD1) and SMu0165 (MSD1).For other 'slo' genes see SMu0164 (sloA); SMu0165 (sloB); SMu0168 (sloR) and SMu1189 (sloC).The work of Kitten and colleagues (2000) identifies this region as an LraI homologous region which encodes ABC related components, hence it has dual function relating to adhesion and transport. The fourth element, sloR, is acknowledged to be a DtxR like regulator. Spatafor et al. (2001) refer to this gene as fimA by analogy with work of Fenno et al. (1995). All camps, including Correeia et al. (1996) view the gene product as an adhesin as well as an ABC element.","ABC transporter element, iron predicted binding protein","Membrane, Periplasm, Extracellular","This sequence was previously published in GenBank as gi8925939. In addition, residues 19-306 are 76% similar to gi1184932 from S.cristatus.Residues 1-309 are 72% similar to a predicted fimA from Streptococcus parasanguis (GI:2147374). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1533 (1e-124).","

InterPro
IPR006127
Family

Periplasmic solute binding protein
PF01297	$\"[8-305]T$	SBP_bac_9

InterPro
IPR006128
Family

Adhesion lipoprotein
PR00690	$\"[29-47]T$ $\"[60-73]T$ $\"[73-90]T$ $\"[191-212]T$ $\"[244-262]T$ $\"[270-289]T$	ADHESNFAMILY

InterPro
IPR006129
Family

Adhesin B
PR00691	$\"[29-50]T$ $\"[54-72]T$ $\"[73-92]T$ $\"[133-152]T$ $\"[191-208]T$ $\"[217-235]T$ $\"[240-257]T$ $\"[262-280]T$ $\"[283-301]T$	ADHESINB

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1980	$\"[21-173]T$ $\"[176-306]T$	G3DSA:3.40.50.1980
PS51257	$\"[1-20]T$	PROKAR_LIPOPROTEIN
SSF53807	$\"[28-306]T$	SSF53807

","BeTs to 12 clades of COG0803COG name: Zn-binding (lipo)protein of the ABC-type Zn transport system (surface adhesin A)Functional Class: PThe phylogenetic pattern of COG0803 is a-tK-QvCeBrH-----LINxNumber of proteins in this genome belonging to this COG is 2","***** PR00691 (Adhesin B signature) with a combined E-value of 2.4e-137. PR00691A 29-50 PR00691B 54-72 PR00691C 73-92 PR00691D 133-152 PR00691E 191-208 PR00691F 217-235 PR00691G 240-257 PR00691H 262-280 PR00691I 283-301***** PR00690 (Adhesin family signature) with a combined E-value of 1.1e-74. PR00690A 29-47 PR00690B 60-73 PR00690C 73-90 PR00690D 191-212 PR00690E 244-262 PR00690F 270-289","Residues 23-119 are 98% similar to a (COMPLETE PERIPLASMIC PROTEOME PRECURSOR) protein domain (PD002751) which is seen in Q9KIJ3_STRMU.Residues 131-248 are identical to a (COMPLETE PROTEOME PERIPLASMIC) protein domain (PD002761) which is seen in Q9KIJ3_STRMU.Residues 250-300 are identical to a (LIPOPROTEIN PERIPLASMIC SIGNAL PRECURSOR) protein domain (PD349584) which is seen in Q9KIJ3_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:22:23 2007","Thu Mar 8 14:06:44 2007","Thu Sep 28 11:48:53 2006","Mon Apr 8 11:22:02 2002","Wed Jan 2 14:04:17 2002","Wed Jan 2 14:04:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0166 is paralogously related (blast p-value < 1e-3) to SMu1189, a predicted surface adhesin (AdcA).","Wed Jan 2 14:10:05 2002","Thu Sep 28 11:48:53 2006","pdb1PSZA Chain A, Pneumococcal Surface Antigen Psaa 443 2e-125pdb1TOAA Chain A, Periplasmic Zinc Binding Protein Troa From ... 135 6e-033","SMU.184","","Residues 8 to 305 (E-value = 1.1e-140) place SMu0166 in the SBP_bac_9 family which is described as Periplasmic solute binding protein family (PF01297)","Wed Jan 2 14:04:17 2002","24378698","","Kitten,T., Munro,C.L., Michalek,S.M. and Macrina,F.L.Genetic characterization of a streptococcus mutans LraI familyoperon and role in virulenceInfect. Immun. 68 (8), 4441-4451 (2000)PubMed: 20359334Spatafora G, Moore M, Landgren S, Stonehouse E, Michalek S. Expression of Streptococcus mutans fimA is iron-responsive and regulated by a DtxR homologue.Microbiology. 2001 Jun;147(Pt 6):1599-610.PMID: 11390691 ","Fenno,J.C., Shaikh,A., Spatafora,G. and Fives-Taylor,P.The fimA locus of Streptococcus parasanguis encodes an ATP-bindingmembrane transport systemMol. Microbiol. 15 (5), 849-863 (1995)PubMed: 7596287Correia,F.F., DiRienzo,J.M., McKay,T.L. and Rosan,B.scbA from Streptococcus crista CC5A: an atypical member of the lraI gene familyInfect. Immun. 64 (6), 2114-2121 (1996)PubMed: 8675315Spatafora G, Van Hoeven N, Wagner K, Fives-Taylor P.Evidence that ORF3 at the Streptococcus parasanguis fimA locus encodes a thiol-specific antioxidant.Microbiology. 2002 Mar;148(Pt 3):755-62.PMID: 11882710","Tue Oct 29 12:21:33 2002","Tue Oct 29 12:21:33 2002","1","","","SMU.184","" "SMu0167","182383","182520","138","ATGGTCTGTCACAATGAGGAAAGGTTTCCGCTTACTCCCAGCTGTTTAGCATATGAAGCTGTTAATAATAAATATCATCACCCAATTAATATGGAAACAGTCTATTCAAATTTTCCTGATAGGATGATGGATAATTAA","5.50","-2.39","5343","MVCHNEERFPLTPSCLAYEAVNNKYHHPINMETVYSNFPDRMMDN","182517","","hypothetical protein","Extracellular","No significant hits in gapped BLAST.SMu0167 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:46:31 2002","Wed Jan 2 14:11:37 2002","Wed Oct 9 08:46:31 2002","Wed Jan 2 14:11:37 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0167 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:46:31 2002","","No significant hits to the NCBI PDB database.","SMU.185","","No significant hits to the Pfam 11.0 database","Wed Jan 2 14:11:37 2002","24378699","","","","","","1","","","SMU.185","" "SMu0168","182584","183237","654","ATGACACCTAATAAAGAAGATTACCTTAAAATTATTTATGAACTCAGTGAACGTGATGAGAAGATCAGCAACAAGCAAATTGCTGAGAAAATGTCTGTATCTGCTCCGGCTGTCTCAGAAATGGTTAAAAAATTACTATTGGAGGATCTGGTTCTTAAAGACAAACAAGCGGGTTATTTGTTGACAAAAAAAGGACAGATTCTAGCGTCATCTCTTTATCGCAAGCATCGTCTGATAGAAGTTTTTTTGATGAATCATCTTAATTACACAGCAGACGAAATTCATGAAGAGGCTGAAGTGCTGGAACATACTGTCTCTGATGTGTTTGTTGAACGTTTAGATAAGTTTCTTAACTATCCTAAGGTTTGTCCGCATGGAGGGACCATTCCTCAACATGGACAGCCCTTAGTAGAGAGGTATCGTACAACTTTAAAGGGTGTAACTGAGATGGGAGTATATTTGTTGAAACGTGTTCAAGATAACTTTCAGTTATTAAAGTATATGGAACAGCATCATTTAAAGATCGGAGATGAATTAAGGCTCCTAGAATATGATGCTTTTGCGGGTGCTTATACCATTGAAAAAGATGGGGAACAATTACAGGTGACATCAGCAGTTGCCAGTCAAATATACATTGAAAAGAAAGCTTACTAA","6.50","-2.11","25061","MTPNKEDYLKIIYELSERDEKISNKQIAEKMSVSAPAVSEMVKKLLLEDLVLKDKQAGYLLTKKGQILASSLYRKHRLIEVFLMNHLNYTADEIHEEAEVLEHTVSDVFVERLDKFLNYPKVCPHGGTIPQHGQPLVERYRTTLKGVTEMGVYLLKRVQDNFQLLKYMEQHHLKIGDELRLLEYDAFAGAYTIEKDGEQLQVTSAVASQIYIEKKAY","183234","For other 'slo' genes see SMu0164 (sloA); SMu0165 (sloB); SMu0166 (sloC) and SMu1189 (sloC).The work of Kitten and colleagues (2000) identifies this region as an LraI homologous region which encodes ABC related components. The fourth element, sloR, is acknowledged to be a DtxR like regulator (See Spatafora et al., 2001).. ","metal-dependent transcriptional regulator (probable DtxR homolog)","Cytoplasm","This sequence was previously published in GenBank as gi|8925940. Also, residues 1-214 are 57% similar to gi|6694218 from S.gordonii.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1534 (4e-66).","

InterPro
IPR001367
Family

Iron dependent repressor
PF01325	$\"[1-45]T$	Fe_dep_repress
PF02742	$\"[62-132]T$	Fe_dep_repr_C
SM00529	$\"[23-122]T$	HTH_DTXR
PS50944	$\"[1-62]T$	HTH_DTXR
SSF47979	$\"[62-137]T$	HTH_DtxR

InterPro
IPR007167
Family

FeoA
PF04023	$\"[142-214]T$	FeoA

InterPro
IPR008988
Domain

Transcriptional repressor, C-terminal
SSF50037	$\"[127-215]T$	Transcr_rep_C

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[6-70]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:1.10.60.10	$\"[71-140]T$	G3DSA:1.10.60.10
SSF46785	$\"[1-61]T$	SSF46785

","BeTs to 10 clades of COG1321COG name: Predicted iron-dependent transcription repressorFunctional Class: RThe phylogenetic pattern of COG1321 is AmTk--v-ebR------lin-Number of proteins in this genome belonging to this COG is 1","***** IPB001367 (Iron dependent repressor) with a combined E-value of 2.3e-27. IPB001367A 6-18 IPB001367B 73-113","Residues 23-102 are 82% similar to a (TRANSCRIPTION DNA-BINDING REGULATION) protein domain (PD001097) which is seen in Q9KIJ2_STRMU.Residues 103-214 are identical to a (REPRESSOR SLOR METALLOREGULATOR DEPENDANT) protein domain (PD353550) which is seen in Q9KIJ2_STRMU.Residues 5-130 are 27% similar to a (PROTEOME COMPLETE REPRESSOR MEMBRANE) protein domain (PD332348) which is seen in Q9HJU1_THEAC.Residues 59-130 are 41% similar to a (MEMBRANE TRANSPORT METAL SYSTEM) protein domain (PD392962) which is seen in Y347_CHLPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 26 19:07:17 2002","Sat Oct 26 19:05:01 2002","Sat Oct 26 17:52:30 2002","Mon Apr 8 11:22:36 2002","Wed Jan 2 14:12:30 2002","Wed Jan 2 14:12:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0168 is paralogously related (blast p-value < 1e-3) to SMu0121, a predicted mleR transcriptional regulator.","Wed Jan 2 14:16:07 2002","Wed Jan 2 14:12:30 2002","pdb|1B1B|A Chain A, Iron Dependent Regulator 73 4e-014pdb|2TDX| Diphtheria Tox Repressor (C102d Mutant) Complexed ... 73 4e-014pdb|1BI1| Structure Of Apo- And Holo-Diphtheria Toxin Repres... 71 9e-014","SMU.186","","Residues 1 to 60 (E-value = 7.6e-11) place SMu0168 in the Fe_dep_repress family which is described as Iron dependent repressor, N-terminal DNA binding domain (PF01325)Residues 62 to 132 (E-value = 7.4e-25) place SMu0168 in the Fe_dep_repr_C family which is described as Iron dependent repressor, metal binding and dimerisation domain (PF02742)Residues 142 to 214 (E-value = 2.2e-13) place SMu0168 in the FeoA family which is described as FeoA domain (PF04023)","Wed Jan 2 14:12:30 2002","24378700",""," Rolerson E, Swick A, Newlon L, Palmer C, Pan Y, Keeshan B, Spatafora G.The SloR/Dlg metalloregulator modulates Streptococcus mutans virulence gene expression.J Bacteriol. 2006 Jul;188(14):5033-44. Erratum in: J Bacteriol. 2006 Sep;188(18):6718. PMID: 16816176Kitten,T., Munro,C.L., Michalek,S.M. and Macrina,F.L.Genetic characterization of a streptococcus mutans LraI familyoperon and role in virulenceInfect. Immun. 68 (8), 4441-4451 (2000)PubMed: 10899841","Spatafora G, Moore M, Landgren S, Stonehouse E, Michalek S. Expression of Streptococcus mutans fimA is iron-responsive and regulated by a DtxR homologue.Microbiology. 2001 Jun;147(Pt 6):1599-610.PMID: 11390691 ","Mon Apr 8 11:22:36 2002","Sat Oct 26 17:56:40 2002","1","","","SMU.186","" "SMu0169","184394","183417","978","ATGACAAAGCTTAATAGCTCATTTATGATTGACAATGTGGAAATTCCTCATCGCACCGTCTTAGCACCAATGGCAGGAGTGACGAATTCCGCTTTTCGAACTATCGCTAAAGAATTTGGAGCTGGACTTGTCGTGATGGAAATGGTATCCGATAAAGGCATCCAATACAATAATGAAAAAACGCTCCACATGCTTCATATTGATGAAGGAGAACATCCTGTTTCTATTCAGCTTTTTGGCAGTGATGGTGATAGTCTAGCACGCGCAGCTGAATTTATTCAAGCTAATACAAAGACTGACCTTGTGGATATCAATATGGGCTGCCCAGTTAATAAAATTGTAAAAAATGAAGCTGGTGCGATGTGGCTCAAAGATCCTGAAAAAATCTACTCCGTCATTTCAAGTGTTAAGTCTGTTTTGAACATTCCTTTAACCGTAAAAATGCGTACTGGCTGGTCTGATGCCTCCCTAGCTGTTGAAAATGCCTTGGCTGCAGAATCAGCTGGTGTTGCTGCTCTTGCCATGCACGGTCGTACCCGAGAGCAAATGTATACTGGCTCATGCGACCATGAAACCCTCGCTAAAGTCGCTAAAGCCATTACAAAAGTTCCTTTTATTGCCAATGGGGATATTCGTAGCGTTGAGGACGCTCAATTTATGATTGACCAAGTTGGCGCAGATGCTGTGATGATTGGTCGAGCCGCCAGAAGCAATCCTTATATTTTCACTCAAATCAATCATTATTTTGAAACAGGAGAAATTTTAGATAATCTGCCATTCGCTAAAATGTTAGAAATTGCCCAAGATCATCTTCGACGTTTGGTAGATCTTAAGGGAGAAAAAATCGCTGTTCGTGAATTTCGTGGCCTAGCACCTTATTACCTTCGCGGTACATCAGGTGCTGCCAAAATTCGCTCAGCTGTCTCACGAGCTGAAACCATTTTGGAAGTCGAGAACATTTTCGCTCAAATCCATTGA","6.40","-2.91","35612","MTKLNSSFMIDNVEIPHRTVLAPMAGVTNSAFRTIAKEFGAGLVVMEMVSDKGIQYNNEKTLHMLHIDEGEHPVSIQLFGSDGDSLARAAEFIQANTKTDLVDINMGCPVNKIVKNEAGAMWLKDPEKIYSVISSVKSVLNIPLTVKMRTGWSDASLAVENALAAESAGVAALAMHGRTREQMYTGSCDHETLAKVAKAITKVPFIANGDIRSVEDAQFMIDQVGADAVMIGRAARSNPYIFTQINHYFETGEILDNLPFAKMLEIAQDHLRRLVDLKGEKIAVREFRGLAPYYLRGTSGAAKIRSAVSRAETILEVENIFAQIH","183420","","probable tRNA-dihydrouridine synthase","Cytoplasm","Several matches in gapped BLAST to conserved hypotheticals and possible transcriptional regulators and dehydrogenases. Residues 1-324 are 72% similar to gi15674339 from S.pyogenes. Residues 1-318 are 72% similar to gi15904035 from S.pneumoniae.See Spy0122.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1825 (1e-142).","

InterPro
IPR000517
Domain

Ribosomal protein L30
PS00634	$\"[61-93]?$	RIBOSOMAL_L30

InterPro
IPR001269
Family

Dihydrouridine synthase, DuS
PIRSF006621	$\"[8-325]T$	Dus
PF01207	$\"[20-325]T$	Dus
PS01136	$\"[102-120]T$	UPF0034

InterPro
IPR004652
Family

Dihydrouridine synthase TIM-barrel protein nifR3
TIGR00737	$\"[10-325]T$	nifR3_yhdG

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[13-257]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
G3DSA:1.10.1200.80	$\"[259-325]T$	G3DSA:1.10.1200.80
PTHR11082	$\"[46-324]T$	PTHR11082
PTHR11082:SF9	$\"[46-324]T$	PTHR11082:SF9
SSF51395	$\"[17-325]T$	SSF51395

","BeTs to 13 clades of COG0042COG name: Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 familyFunctional Class: RThe phylogenetic pattern of COG0042 is amt-YqvCEBrHuj--OlinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001269 (Uncharacterized protein family UPF0034) with a combined E-value of 1.7e-53. IPB001269A 20-40 IPB001269B 91-123 IPB001269C 142-153 IPB001269D 169-192 IPB001269E 202-211 IPB001269F 224-241","Residues 124-229 are 35% similar to a (COMPLETE PROTEOME FAMILY NIFR3 NIFR3/SMM1 HOMOLOG) protein domain (PD002067) which is seen in NIR3_RHILP.Residues 8-122 are 82% similar to a (COMPLETE PROTEOME FAMILY NIFR3/SMM1 NIFR3-LIKE) protein domain (PD002197) which is seen in Q9ZB44_STRPY.Residues 230-296 are 41% similar to a (PROTEOME COMPLETE PMRA-FIS) protein domain (PD004944) which is seen in YHDG_ECOLI.Residues 235-321 are 74% similar to a (PROTEOME COMPLETE INVOLVED) protein domain (PD337377) which is seen in Q9ZB44_STRPY.Residues 230-316 are 37% similar to a (PROTEOME NIFR3-LIKE COMPLETE ML2186) protein domain (PD385189) which is seen in O52533_PROVU.Residues 123-234 are 62% similar to a (ISOMERASE HISTIDINE BIOSYNTHESIS CARBOXAMIDE) protein domain (PD000434) which is seen in Q9ZB44_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:12:44 2002","Tue Sep 19 15:24:32 2006","Wed Feb 22 10:09:26 2006","Tue Feb 26 10:42:51 2002","Wed Jan 2 14:20:38 2002","Wed Jan 2 14:20:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0169 is paralogously related (blast p-value < 1e-3) to SMu1118, a predicted dihydroorotate dehydrogenase B.","Wed Jan 2 14:22:09 2002","","No significant hits to the NCBI PDB database.","SMU.187c","","Residues 20 to 325 (E-value = 6.8e-99) place SMu0169 in the Dus family which is described as Dihydrouridine synthase (Dus) (PF01207)","Wed Jan 2 14:20:38 2002","24378701","","","","","","1","","","SMU.187c","481" "SMu0170","185313","184381","933","ATGTATTTACCAAGTTTCCTTATTATTACTTCTTTGATAATTTATGTTAGAATAATGGATATGGATAAACTTATTAAGTCAATAGCAAAATCGGGATCTTTCCGTGCTTATGTACTCGATAGCACTGAAACGGTCAGAACTGCTCAAGAAGAACATCAATCCCTCTCAAGTTCAACTGTCGCTCTAGGACGTACACTCATTGCCAATCAAATTCTAGCAGCTAATCAAAAGGGAGACAGCAAGGTTACTGTCAAAGTTATCGGTGACTCTTCTTTTGGTCATATTATTTCGGTTGCTGATACCAAAGGAAATGTAAAAGGCTACATTCAAAATGCCGGCGTTGATGTCAAAAAAACAGCTAGCGGTGAAGTTATCGTAGGACCTTTTATGGGAAATGGACAGTTTGTGGTCATCACTGACTATGGAACTGGCAACCCTTATACTTCATCAACGCCACTTGTTTCAGGTGAAATCGGTGAAGATTTGGCTTACTATCTAACTGAAAGTGAACAAACACCATCTGCTGTTGGGCTCAATGTGCTCTTAGATGAAAAGGATAAGGTCAAAGTAGCCGGTGGCTTTATGCTACAAGTCCTTCCAGAGGCTTCTGAGGAAGAAATTACTCGTTATGAAAAACGCATTCAGGAAATGCCTGCTATTTCAACTCTGCTAGAGTCAGAGGATCACATCGAAGCTCTCTTGAAAGCTATCTATGGTGAAGAGGACTATAAAGTTTTAGTCGAGGAAGACTTACAGTTTACCTGTGATTGCTCACGTCAGCGTTTTGAAGCAGCTCTTATGACACTGAGCAAATCTGATCTTAAAGAAATGAAAGAAGAAGACCACGGAGCAGAAATTGTCTGCCAATTTTGTGGTAAAAAATACCAATTTAAGGAAAGTGATTTAGAGGAGATGATTAATGACAAAGCTTAA","4.50","-17.19","34150","MYLPSFLIITSLIIYVRIMDMDKLIKSIAKSGSFRAYVLDSTETVRTAQEEHQSLSSSTVALGRTLIANQILAANQKGDSKVTVKVIGDSSFGHIISVADTKGNVKGYIQNAGVDVKKTASGEVIVGPFMGNGQFVVITDYGTGNPYTSSTPLVSGEIGEDLAYYLTESEQTPSAVGLNVLLDEKDKVKVAGGFMLQVLPEASEEEITRYEKRIQEMPAISTLLESEDHIEALLKAIYGEEDYKVLVEEDLQFTCDCSRQRFEAALMTLSKSDLKEMKEEDHGAEIVCQFCGKKYQFKESDLEEMINDKA","184384","","Hsp33-like chaperonin","Cytoplasm, Membrane","Several matches in gapped BLAST to HSP33 proteins. Residues 21-310 are 81% similar to gi15674340 from S.pyogenes and are 76% similar to gi15901995 from S.pneumoniae. See Spy0123.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1824 (1e-134).","

InterPro
IPR000397
Family

Hsp33 protein
PD248154	$\"[133-196]T$	HSLO_STRMU_Q8CWZ3;
PF01430	$\"[21-299]T$	HSP33

noIPR
unintegrated

unintegrated
G3DSA:3.55.30.10	$\"[21-254]T$	no description
G3DSA:3.90.1280.10	$\"[255-308]T$	no description
signalp	$\"[1-18]?$	signal-peptide

","BeTs to 5 clades of COG1281COG name: Uncharacterized BCR, YrfI familyFunctional Class: SThe phylogenetic pattern of COG1281 is -----qvceb-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB000397 (Hsp33 protein) with a combined E-value of 2.4e-69. IPB000397A 34-76 IPB000397B 82-101 IPB000397C 135-180 IPB000397D 251-281 IPB000397E 288-295","Residues 35-193 are 87% similar to a (HEAT SHOCK CENTER CHAPERONIN) protein domain (PD014025) which is seen in HSLO_STRPY.Residues 196-305 are 47% similar to a (HEAT SHOCK CENTER CHAPERONIN) protein domain (PD248154) which is seen in HSLO_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 22 10:12:54 2006","Tue Sep 19 15:07:16 2006","Wed Feb 22 10:12:54 2006","Wed Feb 22 10:12:54 2006","Wed Jan 2 14:22:55 2002","Wed Jan 2 14:22:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0170 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 14:25:17 2002","","No significant hits to the NCBI PDB database.","SMU.188c","","Residues 21 to 299 (E-value = 8.4e-145) place SMu0170 in the HSP33 family which is described as Hsp33 protein (PF01430)","Wed Jan 2 14:22:55 2002","24378702","","","Graumann J, Lilie H, Tang X, Tucker KA, Hoffmann JH, Vijayalakshmi J, Saper M, Bardwell JC, Jakob U.Activation of the redox-regulated molecular chaperone Hsp33--a two-step mechanism.Structure (Camb). 2001 May 9;9(5):377-87.PMID: 11377198Vijayalakshmi J, Mukhergee MK, Graumann J, Jakob U, Saper MA.The 2.2 A crystal structure of Hsp33: a heat shock protein with redox-regulated chaperone activity.Structure (Camb). 2001 May 9;9(5):367-75.PMID: 11377197Jakob U, Eser M, Bardwell JC.Redox switch of hsp33 has a novel zinc-binding motif.J Biol Chem. 2000 Dec 8;275(49):38302-10.PMID: 10976105 ","","Wed Jan 2 14:32:57 2002","1","","","SMU.188c","480" "SMu0171","185427","185633","207","ATGAAAAGCCAAGAGGTTCATCAGTGTATTTTCGGAGGCAGTGCTAGAGTGTTGCGAAAGGGGACTAAAAAGGCGTGGTTTGGGGGAAGAGAGGTATATAAAGGAAATAAAACAGAAAAAAAGCGAGAAAAGCTATTGACAAAGGGGGGAAGAGCTGGTAGAATAAAGAAGTTGTCTCAGAAAGAGGCAGAGCCCTTTGAAAACTGA","11.20","12.18","7719","MKSQEVHQCIFGGSARVLRKGTKKAWFGGREVYKGNKTEKKREKLLTKGGRAGRIKKLSQKEAEPFEN","185630","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST.SMu0171 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:48:57 2002","Wed Jan 2 14:35:41 2002","Wed Jan 2 14:36:20 2002","Wed Jan 2 14:35:41 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0171 is paralogously related (blast p-value < 1e-3) to SMu0015, a hypothetical.","Wed Jan 2 14:36:20 2002","","No significant hits to the NCBI PDB database.","SMU.189","","No significant hits to the Pfam 11.0 database","Wed Jan 2 14:35:41 2002","24378703","","","","","","1","","","SMU.189","" "SMu0172","193192","192029","1164","ATGATAAATATGTATATTCCTCAATTCAATCCACGGATTAGAAAAGACCAAAAATCAGGTCTTTTCTTTTTTGAAATTAGAGATAATGAAGGTAAGACTGTTTCATATCAGTCAGGATTTAATACCAAGCGAGAGGCAGAGAATACTGCATTAGAAATTCAACAGAAATTAAGACAGGGATATACACTTGATAGATATACTTCTCTTTATGATTGGTTTCAAACATGGTATGATTTAAAAATTCGACCAAAGAAAAAATTATCTCAAGAGACAAAGAAAAATTATCAAATTTATGGAGAAACCTTAAAACGTCTTTTTGGTGATAAACCTATTATTGATATTAAATCAAGCCAATATCAAAGGATTATGAATGTTTATGGAGAAACAGTTGGTTATGACTATCTTAGTAGAATAAACTCAGTAATCAGAAAAATCATCAAGTTAGCACAGTCAGATAAAATCGTTATTGATGATTTTACTTCAACAGTAGAATTATTTGCTGGAAAAGATGGGCAAAAGGTAAATGAAAAATATATTCATAGTGTTGAGGATTATCATAGGTTAATTTCATACTTAGAAAATAACTTAAATTATGAAGATTCAGTGGTCAATCATGTTATTTATGTAATCGCAAAAACAGGTATGAGATATGGTGAAATAATTGGATTAACAAATAATGATACAAGTTTAGATGAACATTATTTGCATACATATAAGCGTTATAATACATCAACATGGAAATGGACAAATGCTAAAAATGAATCTTCTAAAAGATATATACCAATAGATGATAAAATAGTTGCTGCTCTTTCTAACATGATAAAAGAACGAGAAAGAATAAACTCATTACTACGAATAAAAAACAAAGAAGAATTTCTTTTCTTCCACTATGGTCTAGAACATGGTATTCCTTCAGTAGCTACAGTAAACAAAGCTTTGAAAAAAATACTAAAAAAGCTTGATATAGAGCCAATAATAACGACTAAAGGACTTAGACATACTTACGGTTCATATTTACTTCATAATAATATAGATATGGGGGTTGTGGCTAGAATTTTAGGTCATAAAGATATCCAAATGTTGATACAAGTTTATGGTCATACACTTACTGAAAAGATTGATAAAGAGTTTAAAGAGGTTGAACAAATTATGAATAGAATATAA","10.20","14.67","45624","MINMYIPQFNPRIRKDQKSGLFFFEIRDNEGKTVSYQSGFNTKREAENTALEIQQKLRQGYTLDRYTSLYDWFQTWYDLKIRPKKKLSQETKKNYQIYGETLKRLFGDKPIIDIKSSQYQRIMNVYGETVGYDYLSRINSVIRKIIKLAQSDKIVIDDFTSTVELFAGKDGQKVNEKYIHSVEDYHRLISYLENNLNYEDSVVNHVIYVIAKTGMRYGEIIGLTNNDTSLDEHYLHTYKRYNTSTWKWTNAKNESSKRYIPIDDKIVAALSNMIKERERINSLLRIKNKEEFLFFHYGLEHGIPSVATVNKALKKILKKLDIEPIITTKGLRHTYGSYLLHNNIDMGVVARILGHKDIQMLIQVYGHTLTEKIDKEFKEVEQIMNRI","192032","","phage-related integrase","Cytoplasm","Matches in gapped BLAST to phage-related integrases. Residues 14-387 are 27% similar to gi6465906, an integrase from bacteriophage TPW22. Residues 27-387 are 27% similar to gi13095806, a prophage pi1 protein 01, integrase, from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1986 (3e-92).","

InterPro
IPR002104
Domain

Integrase, catalytic core, phage
PF00589	$\"[191-375]T$	Phage_integrase

InterPro
IPR011010
Domain

DNA breaking-rejoining enzyme, catalytic core
SSF56349	$\"[178-378]T$	DNA_brk_join_enz

InterPro
IPR013762
Domain

Integrase-like, catalytic core, phage
G3DSA:1.10.443.10	$\"[181-378]T$	Phage_intgr_like

","BeTs to 9 clades of COG0582COG name: IntegraseFunctional Class: LThe phylogenetic pattern of COG0582 is aMtK-qvcEBRHUJ---LINXNumber of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 331-384 are 40% similar to a (INTEGRASE COMPLETE DNA PROTEOME) protein domain (PD000437) which is seen in Q38086_VVVVV.Residues 37-149 are 32% similar to a (INTEGRASE DNA COMPLETE PROTEOME) protein domain (PD006818) which is seen in O21990_VVVVV.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 17:28:14 2006","Wed Jan 2 14:41:10 2002","Thu Aug 31 17:28:14 2006","Thu Aug 31 17:28:14 2006","","Wed Jan 2 14:41:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0172 is paralogously related (blast p-value < 1e-3) to SMu0200, SMu0942, and SMu0201, all suspected integrases.","Wed Jan 2 14:42:34 2002","","No significant hits to the NCBI PDB database.","SMU.191c","","Residues 180 to 375 (E-value = 1.8e-08) place SMu0172 in the Phage_integrase family which is described as Phage integrase family (PF00589)","Wed Oct 9 08:50:22 2002","24378704","","","","","","1","","6","SMU.191c","606" "SMu0173","193384","193199","186","ATGGAAAAACAACTTATTACAAAAAATGACCTTATTAAGCAAGGCTTAAAAGAGGGGACAGCAAAAAGAGTGATTCGTGAGGCTAAAATGTTACTTGTAAATCAAGGTTTTAAATTTTATAGCAATAAACGTTTAGGAGCAGTTCCGGTCAGTATCGTTGAGGAAATCCTTCATGTAAAATTTTAA","10.80","6.22","6982","MEKQLITKNDLIKQGLKEGTAKRVIREAKMLLVNQGFKFYSNKRLGAVPVSIVEEILHVKF","193202","","conserved hypothetical protein","Cytoplasm","A couple very weak matches in gapped BLAST to hypothetical proteins. Residues 6-60 are 41% similar to gi|16612084 from E.faecalis. Residues 6-61 are 35% similar to gi|15923383 from S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1987 (1e-08).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:50:45 2002","Wed Jan 2 14:46:34 2002","Wed Oct 9 08:50:45 2002","Wed Jan 2 14:46:34 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0173 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:50:45 2002","","No significant hits to the NCBI PDB database.","SMU.193c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 14:46:34 2002","24378705","","","","","","1","","6","SMU.193c","1032" "SMu0174","193639","193388","252","ATGACAACTCATAAAATAAAATTATCTCATTGTTTTTTTGATGATGTGGCTAGTGGCCGTAAAAACTTTGAATTACGTAAAAACGATAGGCATTATCAAGTTGGTGATTGTTTATGTTTATGTGAGGTTAAAGAAAAACGCTTAACAGGTCGTAAACTAATGGTTGCTGTTACTTATAAATTACAAGATTTTACTGGATTATCAGATGGTTATTGCATTTTAGGGATTGAAAATGTAAGAAAGGAAGGATAA","8.60","4.47","9555","MTTHKIKLSHCFFDDVASGRKNFELRKNDRHYQVGDCLCLCEVKEKRLTGRKLMVAVTYKLQDFTGLSDGYCILGIENVRKEG","193391","","conserved hypothetical protein, phage-related","Cytoplasm","A few weak hits in gapped BLAST to hypotheticals. Residues 4-76 are 38% similar to gi|141345 from E.coli retron Ec67. Residues 4-69 are 43% similar to gi|9630367 from phage P2.SMu0174 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-74 are 38% similar to a (ELEMENT RETRON ORF5 ORFD) protein domain (PD029860) which is seen in YR7D_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:51:21 2002","Fri Jan 3 15:51:12 2003","Fri Jan 3 15:51:12 2003","Wed Jan 2 14:50:44 2002","","Wed Jan 2 14:50:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0174 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 08:14:02 2002","","No significant hits to the NCBI PDB database.","SMU.194c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 14:50:44 2002","24378706","","","","","","1","","6","SMU.194c","" "SMu0175","193935","193675","261","ATGTTAACAAAAGAAAAATGTGCTGAATTAGGTATTATGAAATGGGTTAAAAAACCTATCCCAGTTTATGCTATTCAGCTAGTTGAAAAAAATAAAGATGTGTTAAGAAATGAAGAACGTCTCAATTATGATGATCGCACTGTTCAAACCCTTGAAGGACAATTTCATTTTGATTATGGTGATTACTTAGTTGTCGGTAATGATAATGAAGTTTGGACAGTGAAGCAAGTTATTTTTGAAGCGACGTATGAGCAAGTTTGA","4.70","-3.81","10168","MLTKEKCAELGIMKWVKKPIPVYAIQLVEKNKDVLRNEERLNYDDRTVQTLEGQFHFDYGDYLVVGNDNEVWTVKQVIFEATYEQV","193678","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0175 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PD063101	$\"[13-84]T$	PD063101

InterPro
IPR007921
Domain

Cysteine, histidine-dependent amidohydrolase/peptidase
PF05257	$\"[240-363]T$	CHAP
PS50911	$\"[235-363]T$	CHAP

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 311-358 are 72% similar to a (PLASMID TRAG-RELATED FRAMES PAD1) protein domain (PD406242) which is seen in Q9L4G7_STRTR.Residues 252-362 are 56% similar to a (PRECURSOR SIGNAL PLASMID SECRETED) protein domain (PD012961) which is seen in Q54707_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:53:26 2002","Tue Oct 8 08:14:25 2002","Tue Sep 19 10:28:26 2006","Wed Jan 2 14:57:05 2002","","Wed Jan 2 14:57:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0176 is paralogously related (blast p-value < 1e-3) to SMu0018, SMu0332, SMu0760, and SMu0894, glucan-binding proteins and hypotheticals.","Wed Jan 2 15:00:12 2002","","No significant hits to the NCBI PDB database.","SMU.196c","","Residues 240 to 363 (E-value = 1.7e-37) place SMu0176 in the CHAP family which is described as CHAP domain (PF05257)","Wed Jan 2 14:57:05 2002","24378708","","","","","","1","","6","SMU.196c","969" "SMu0177","197498","195072","2427","ATGCATTATTTGAAAAGGTTTTTCTGTTTGGGGTTGCCTTTTTTGTTGTTGATTAGCTTTGTTCAGCCGATAACAGCGGATTCTATTGCTTCAAATGGTTCTTCTCTTAATGGAAACAGTCAAGCTGATATTGGTCCGGATAATTCACAGTATCAGACTCCTGCTCAAAAAGAGATTCAGGGAGTACAGGCTAAAAGCAAACAGAAAGAAGCTAAGAAGGAAAAGAAGGTAGCTGATACTCTGACTGCTGATGAGGATTATCAAAAAGCTTCTAAAGCTGATGATCGTTTGCAAAAATACTATAAAAAAGAAAATCCTAGTGAAGTTGAAATGCAGAAGGCTATCAAAGATTATAATACCATTGAGAAATTTCTGCATGATAAAAGCAACGAAAAGAAATATAAAGATAGCACTAAGTGGCAGAGTCTATCTGCTAATTTTGAATCTTATAACACTAAAATCAGTGCTGTGAAAGATGGTGTTAAAGCGATCACAGAAGCACAAAAAAAGTATGAGAAGGCTATGACTAGTAAAGACCCCGCTGATTTGGCTATTCTTACTTCTTATTTTTATGGAGAAGATGGCTGGTTTGGGGTAAAAGATATTTTTCCAAAAGCAGTTAACTCTTTAATTCAGGGGATTTTTTTCTTAGGAAAAATGATTTACCTTTTGGTGGTTATTATTTTAGAAGCGGTCTTTAGTACTAACTTTTATGCTTTTTTGGATAAAGCTGTGGAGTTGTCTGGTAATGCTTTTAATCATATTATGGATGCTTATGGTGTTTATATTTTTATGGCTACTGGTTTGTTAGGTGTTTTGGAATTTGCCCGAAAGGGTAAGATTCCATTAAAATTATTTCAGTTTTTTTTGATTTGGCTGGTGGCTTTGTTTTTGTATCAGCCTTCTAATTTTAATACGGATGTTGATCATTCTGAGATTACAGCGTCTTATAATCTTTCTAAAGTGGTTAAAATTGTTGATGTGGTGAGTTCTGAGCTTTCAGGTCAAGCTATTAAGGGGTTAGGATTGTTAGATGGTCAAAAGCAAAACAGCCAGTCGTCAGCACCTGTCTCAACAGCTGACGGTTTTCAAGCTTTACGTAAAACTATTTTTAAGGAAATGGTCTTAGAACCGTTTTATAGCTTAAATTTTTCAGCGGATTTCATCCAGAACAGTACTTCTGATGATTTAGATACAGCAGTAAATAAATTAATTAGTACTAAAGGAACTTCTGATAATGTTAAAAATTTTGCAGAAAGTAAAGATTATAAGGGACAGACTACTTTAAATTGGTCTGCTATTGGGGTGAAATTTTTAGTGGCACTTGCTGCTTTGGCTAAAGCTATTATTTTAGGTGGTGCTTTAGTTATTTTGGGCCTTGTCTCTGTCGTGTTTAAGTATTTGGTTTTAATTATTATTGCCATGTCTATGTTGTTGTTCTTTGTTGCTTTACTGCCTAAACTAGATTATGTTTTAGGGAATACGCTTAAGAAAATTGTTCAATATGCTTTTGTTGGCGGTCTTGGTTTATTTGGTGTCACTTTGTTTATCTGGATTAATAGTTTAATTGGTGTTGCAGCTGATAGTTTTTCAGGTGGTGTTTATTATTGGTCTGCTCTTTTGGAAGGCATTATTTGGTTCTTGATCTATCTGTTTCGTGGTAGTATTGCTTCTTTGTTTTCTAAAGGTGGAATGCGTTTACACGATTTAACTTCTGCTGCTCAATTTCGCTTGAATAAGTTTTATCGGCCTTCTCATTTTGAAGCAGATAGAGAGGGGCTTAAACGTCAATTGGAACGTTCTCAAGTAAAAGAAATGCTTCCTGTTAATCAGCGGCAACCTTCCCGTTTTAGGACTTTGTTGCGGGCTTCTCGAGCTGGTACAGAACAACTTTATGATCGTTTGCGTTATGGTGTTGGCAGTAATCCTCAGAAACGTTATATCCAACAGAACCGTGCTGAACGTCGTAGGAATTTTAAGCAAATGCTTCAAGATCGTAAAGAAGCTTTGCAGGATCATGCAGCTAATTTAATGACTTTTGCACAGCCTCGTGCTTTTATCCATGATTTAGCTGGTGATGAGGATACTCCTATTCAAAGACATGTTTCTGAACGTTCTCAGCGTCAAGTGGAGCGTTTGAGTCGTAAGCAAGTTGATGAACAGGCTTATATGGAAGATTTACGTGCTATGAAACGATTGAAAGGTCAAAGAAGCTTTAAAGATATGTCTGCTAAACAAGAACGCCGAGCGGTTAAAAATTTCAAACAAGAAGTTTACTTAAGAAAACATGGTGTGATTGATATGGATACTGTTCGCCGTGATCGGATTAATCGTCATTTAGATCGTGTGGAAAACCGAAGAGAAAGATTACGGCGTACTCAGTTACGTCAGCAGGAAAAAATAAAGCAGTCTTTATTTCAGACTTAA","10.50","34.66","92017","MHYLKRFFCLGLPFLLLISFVQPITADSIASNGSSLNGNSQADIGPDNSQYQTPAQKEIQGVQAKSKQKEAKKEKKVADTLTADEDYQKASKADDRLQKYYKKENPSEVEMQKAIKDYNTIEKFLHDKSNEKKYKDSTKWQSLSANFESYNTKISAVKDGVKAITEAQKKYEKAMTSKDPADLAILTSYFYGEDGWFGVKDIFPKAVNSLIQGIFFLGKMIYLLVVIILEAVFSTNFYAFLDKAVELSGNAFNHIMDAYGVYIFMATGLLGVLEFARKGKIPLKLFQFFLIWLVALFLYQPSNFNTDVDHSEITASYNLSKVVKIVDVVSSELSGQAIKGLGLLDGQKQNSQSSAPVSTADGFQALRKTIFKEMVLEPFYSLNFSADFIQNSTSDDLDTAVNKLISTKGTSDNVKNFAESKDYKGQTTLNWSAIGVKFLVALAALAKAIILGGALVILGLVSVVFKYLVLIIIAMSMLLFFVALLPKLDYVLGNTLKKIVQYAFVGGLGLFGVTLFIWINSLIGVAADSFSGGVYYWSALLEGIIWFLIYLFRGSIASLFSKGGMRLHDLTSAAQFRLNKFYRPSHFEADREGLKRQLERSQVKEMLPVNQRQPSRFRTLLRASRAGTEQLYDRLRYGVGSNPQKRYIQQNRAERRRNFKQMLQDRKEALQDHAANLMTFAQPRAFIHDLAGDEDTPIQRHVSERSQRQVERLSRKQVDEQAYMEDLRAMKRLKGQRSFKDMSAKQERRAVKNFKQEVYLRKHGVIDMDTVRRDRINRHLDRVENRRERLRRTQLRQQEKIKQSLFQT","195075","","hypothetical protein","Membrane, Cytoplasm, Extracellular","No significant hits in gapped BLAST.SMu0177 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002086
Domain

Aldehyde dehydrogenase
PS00687	$\"[245-252]?$	ALDEHYDE_DEHYDR_GLU

noIPR
unintegrated

unintegrated
SSF103473	$\"[447-789]T$	SSF103473

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:53:52 2002","Wed Jan 2 14:58:36 2002","Wed Oct 9 08:53:52 2002","Wed Jan 2 14:58:36 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0177 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:53:52 2002","","No significant hits to the NCBI PDB database.","SMU.197c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 14:58:36 2002","24378709","","","","","","1","","6","SMU.197c","" "SMu0178","200041","197498","2544","ATGTTAGAAAATGTTATAGATAATTCAGTTTTGCATAATAAAATTTTAGATTTAAAAGATAATTTAATGTTGATGGAAGATGGTTCTGTTTTCGCTTTATATGAGATACCTGCTCACATTATGAACATGGTTGATGATAAGAAAAAAGAACGATTGAAACATGGAACATCATACGCTATTGGTAATTTGCAGCCTTATGAAGATTTTGATATTGCAATGGTTCCTTTTCCATTGGATTTAGAAAATAAATATTTACAGTTATCAAAGGATATTGCTGACGACGACACTGCTGATTTTGCTTATTATATGTTAGATAAGTCTTATACTTCTTTGTATGCTAATCAGGAATTATATGAGTATCATTATTTTATGTCTATTCCTTTAAAATCATTATCTATTTCAATAGATTTGAAAAAAGTTTTAAAAACGACTCTAGACAGTACGGTAAGAGGATTTGCTAAATTTCTTGGCCAAGGTATTTCGGTTTTGGAAGGTTGGGAAAAAGACTATTCTCTTATGGTGGAAGAGTTAGAGAAACAACTTACTTCTTTAAAACCAATACGGCTAACGACTAAAGAAAATATCTTTATCAATTCTTATTTTTATATTCGTGGATTGGATATTGATCGAGAACATCAAGTTAAATTAGTAGAAAGTTATATTGATAATATTGATGATGTTTCCGTGTCTTATGAAAATTATAATATTTTGACAATTCATTGTGAAGATAGGAAACATTATATTGCTATGCTGCCTTTAGCTTATGAGCCTGAAAACATGAGTTACTTGCATTTAATTGAGCAGATTCATTCTTTTAATTTTCCAGTAGAGGTTTTTACTAAGGCAAAGTTTGCTAAGACAAAAGGGACTCCATTTAATAATATTCGTTTCAAGGTTCGTCAAGCGCGTAAATTTTTGAAGAATACTGAGGAAGAAAGTTTTGAAGCGGATAGTGTTGATAAAAAGTCAACTAGTCGTTCTAAATATTTAGTAGAAGATGCTGAACAGAAAATTGATGAAAAAGTTCCTATGCTTAATTATTTGCAGACTTTTTTAGTGTTTGATAATGATTTAGATGTTTTAAAGCGAAAAATTGATATTATTGTGGATGCCTTAAAATTTTGTAAAATTCGTTTATCACGTGCTACTGCAGATCAATTTTATCTTTATTATAAGAATAGGTTTGGAACGATTTTAGAGCCTCAGGATAAGAATTTTATTCAACCTGTTGAAATTGATGGATTTTGTGAAAATCTCTTTTTTATTGATCGCAAAATTGGTCAGGATATTGGTTTTTATCTTGGACGTATTGATTCGGAAATGGATAGTTGGGTTGCTGATCCAGATGAGGCTTTGAAAGCCAGTAATAAGTTATTTTTTCTTAATCCTTTTCAGGCTAATAAAGTTGGAATTAAAGGCAAAGCTAATTCTAATCCTAATACGCAGCTGTCGGGGGATACAGGGGAAGGAAAGTCTTTTGCAGCTAAGTTAATCCATCTTTATTCAAGTTTTCTTAAGGTTAAAACGTTGTATATTGATCCTAAATTAGAAATGGAAGCGAACTATAAACGAGTGCTAAAAGAATTTGAAGAACAAGACGTTTATCCGGAGATTCAGAAGTATATTCGCAGTCTTAGTTTCGCAACATTGGATAGTACGAAAAATGAAAATTTAGGAGTTCTGGATCCATTAGTTTTTCTGCCTAAGAAACGTGCTAAAGGCTTAATTGTGTCTATGATTGGAGAACTTATCAAGTATGATAGTCATATCTCTTTTAAAACAGAGTTGTCACATCAGCTTTCTTTGTTTGCGGATAGACGAGCCAGAGGGGAACAGGTGGGAACTTTAACTGTTCTTAAAGAATTATATAATCATTCAGAACGGCAAGATGTTAGAGATACTGCTGAAAGTTTGATTGAAGATATTAAGGATTCGATTTTGGGGCTGGTCTTTTCAGATGGTAAAAATCAAGCAGTTGATTTGAATGCTCGAAATGTTATTTTAGGTGTTTCTGGTTTAGATTTGCCTCAAGATGATAGCATTGTTCATAGTGATTTGACTTTACAGCAGCGATATTCATTGGTTATTATGTATGCTTTAGGTGAATTTGTTATTCAATTTGCAGAGAGGGACTATAAAGAACATACTTTAGAAATTGTTGATGAAGCTTGGTTTTTGGAAACTAGTGCGGTTGGCCGAGGAATTTTTAACCGTATGAAACGTTTGAATCGTCGTTTTAATAATTTTTTGTACTTTGTTTCTCAAGAAATTGATGATAGCAATCGTGGAAAAGATGAGAAAACAGCATTTGGTTCTTACTTTTGCTTTCGCAATGATGATAGTACAAAGGTTGACAGTATTTTACGCCGTTTAGGTGTTCAGCCGACAGAAGAAAGTAGAAAGTGGTTTGATAATCTTTCTCTCGGTCAATGTCTTTATAGAGATTCTGCTAATCGTGTTGAACGTGTTACTTTTGATGGTCTCTTTCCAGAAGTTAAGGAATTGTTTAAAACAGTTGAGAATGATAGTCTGGAGGCGATTTAA","5.10","-22.51","98077","MLENVIDNSVLHNKILDLKDNLMLMEDGSVFALYEIPAHIMNMVDDKKKERLKHGTSYAIGNLQPYEDFDIAMVPFPLDLENKYLQLSKDIADDDTADFAYYMLDKSYTSLYANQELYEYHYFMSIPLKSLSISIDLKKVLKTTLDSTVRGFAKFLGQGISVLEGWEKDYSLMVEELEKQLTSLKPIRLTTKENIFINSYFYIRGLDIDREHQVKLVESYIDNIDDVSVSYENYNILTIHCEDRKHYIAMLPLAYEPENMSYLHLIEQIHSFNFPVEVFTKAKFAKTKGTPFNNIRFKVRQARKFLKNTEEESFEADSVDKKSTSRSKYLVEDAEQKIDEKVPMLNYLQTFLVFDNDLDVLKRKIDIIVDALKFCKIRLSRATADQFYLYYKNRFGTILEPQDKNFIQPVEIDGFCENLFFIDRKIGQDIGFYLGRIDSEMDSWVADPDEALKASNKLFFLNPFQANKVGIKGKANSNPNTQLSGDTGEGKSFAAKLIHLYSSFLKVKTLYIDPKLEMEANYKRVLKEFEEQDVYPEIQKYIRSLSFATLDSTKNENLGVLDPLVFLPKKRAKGLIVSMIGELIKYDSHISFKTELSHQLSLFADRRARGEQVGTLTVLKELYNHSERQDVRDTAESLIEDIKDSILGLVFSDGKNQAVDLNARNVILGVSGLDLPQDDSIVHSDLTLQQRYSLVIMYALGEFVIQFAERDYKEHTLEIVDEAWFLETSAVGRGIFNRMKRLNRRFNNFLYFVSQEIDDSNRGKDEKTAFGSYFCFRNDDSTKVDSILRRLGVQPTEESRKWFDNLSLGQCLYRDSANRVERVTFDGLFPEVKELFKTVENDSLEAI","197501","","conjugative transposon protein","Cytoplasm","Several matches in gapped BLAST to conjugative transposon proteins. Residues 21-844 are 30% similar to a transposon protein from B.subtilis (gi16077561). Residues 15-840 are 28% similar to a conjugative protein from Streptococcus thermophilus (gi6782406).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2001 (2e-83).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 21-838 are 30% similar to a (PROTEOME COMPLETE ORF16 YDDE) protein domain (PD361340) which is seen in P96642_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 13 13:57:56 2007","Wed Jan 2 15:00:48 2002","Tue Mar 13 13:57:56 2007","Wed Jan 2 15:00:48 2002","","Wed Jan 2 15:00:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0178 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 15:04:36 2002","","No significant hits to the NCBI PDB database.","SMU.198c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:00:48 2002","24378710","","","","","","1","","6","SMU.198c","" "SMu0179","200441","200061","381","ATGGAAATTGAAAGAAAGGATAAGGAAGTTTATAACTATAAGCAAGCTTTAGAACAGCCGATTTGGATACAAAAAATTACGGATACTTTTTCGTTAAAAAATGCTATCCGTTTGTCTACTATTATTTGGTCTATTTGTGTGGCTATTATGTTATTGTTATTAGCTTCTTTAGTGTCTAGATTTACTTTTATCCCATTTCCTTTTTTAGCGACATTGGCTGTTATGGCTTCTTGGACTTTGGGAATGTTACTATCTGAGTTGAAGATAGAAGAGAAAACTGTTCTTCGTTTTACTTTTGATTATCTAAAATTTTATTTAGTATACGGACGTAAAGCAAAGACACATTATCTAAATAAAGGTTTTTTATATAAGAAAAAATGA","10.50","9.18","14884","MEIERKDKEVYNYKQALEQPIWIQKITDTFSLKNAIRLSTIIWSICVAIMLLLLASLVSRFTFIPFPFLATLAVMASWTLGMLLSELKIEEKTVLRFTFDYLKFYLVYGRKAKTHYLNKGFLYKKK","200064","","hypothetical protein","Membrane, Cytoplasm","No signifiacnt hits in gapped BLAST.SMu0179 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-79]?$	signal-peptide
tmhmm	$\"[40-60]?$ $\"[66-84]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-28]?$	signal-peptide
tmhmm	$\"[12-31]?$ $\"[37-57]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[45-65]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 153-313 are 24% similar to a (YDDB PROTEOME COMPLETE) protein domain (PD033597) which is seen in O31491_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 26 10:46:00 2006","Tue Sep 26 10:46:00 2006","Tue Sep 26 10:46:00 2006","Wed Jan 2 15:13:32 2002","","Wed Jan 2 15:13:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0181 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:36:26 2002","","No significant hits to the NCBI PDB database.","SMU.201c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:13:32 2002","24378713","","","","","","1","","6","SMU.201c","" "SMu0182","202179","201706","474","ATGATAGCAATGATTAGAATTAGGGATGGAACGAGTAGTTCAGCTCTGTGTAAGCTGGATTTAATGCGATTTACTGAAGAGCAGGTTAGAGAACGTATGTCTGAAAGAGGTATTAGAGATGATGCCTTTTTTGTTTGTGGTTTTGTTGATTGGGAAGTTGATCGAGTCATGACATTTCAAGAAGCTTATGCTTTGAAAAAGTGTATTTTGGGTTTATATGATGGTGATGATTATGTTGTTCAGGAACTTCTGAAACGTCAGAAGCCTTTTGGAGAGATTATCAGCAGTTGTTATGAGTTTTGTTCTAAAAATGAGGTGGAAACAGTGCAAAAGCTTTTATCAGGACTGGGGCCTGAAGAGTTAGTTAATTGTTTTTATAAGTTTTGCTCCTGGCCTCGTTTAGTAGCCAATTATATAAATGCTGGTTACCTTTTGCAAACAAGTAAAGGGTTCTATTTAAATCGTTTTAGGTAA","5.50","-1.33","18300","MIAMIRIRDGTSSSALCKLDLMRFTEEQVRERMSERGIRDDAFFVCGFVDWEVDRVMTFQEAYALKKCILGLYDGDDYVVQELLKRQKPFGEIISSCYEFCSKNEVETVQKLLSGLGPEELVNCFYKFCSWPRLVANYINAGYLLQTSKGFYLNRFR","201709","","conserved hypothetical protein/Streptococcus-specific protein","Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2010 (3e-40).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 26 10:52:27 2006","Tue Mar 6 12:56:54 2007","Tue Mar 6 12:56:54 2007","Wed Jan 2 15:14:41 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0182 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:37:36 2002","","No significant hits to the NCBI PDB database.","SMU.202c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:14:41 2002","24378714","","","","","","1","","6","SMU.202c","" "SMu0183","202430","202302","129","ATGAGGTTTAAACGTTTTGACAGAGATTATGCTTTGAGTGGTGATAATGTTTTTGAAGTGTTAACTGCTTCGTGTGATGTTATTGAACGTAATTTATCTTATCGTGAAATGTGTGGTCTTATGCAATGA","4.90","-1.11","4963","MRFKRFDRDYALSGDNVFEVLTASCDVIERNLSYREMCGLMQ","202305","","hypothetical protein","Periplasm, Extracellular","No significant hits in gapped BLAST.SMu0183 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:38:01 2002","Wed Jan 2 15:33:23 2002","Wed Oct 9 17:38:01 2002","Wed Jan 2 15:33:23 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0183 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:38:01 2002","","No significant hits to the NCBI PDB database.","SMU.204c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:33:23 2002","24378715","","","","","","1","","6","SMU.204c","" "SMu0184","202765","202493","273","ATGCCACAATCGAAAAATGAACAAGATAAAAAAGTTTTGAGTGTCGTTCAAGAGTTATCTCAGTTGCTTATTGGGTATAAGTATGATGAAGCGTGGGGGAAAGCTGGAGAATTGAGTGGTTTGTTAAAAAACACTGAAAGTCTAACACTACCTTCTTATATGTTAGATATGTTAAAACAACATTTAAAATCTTATTATTATCAACAGGAGCAGGTTAATAAGTCTCATAAAGCTCAGTTGGCTATTGGTCATAAATTAGAAGATTTTCAGTAA","7.80","0.71","10386","MPQSKNEQDKKVLSVVQELSQLLIGYKYDEAWGKAGELSGLLKNTESLTLPSYMLDMLKQHLKSYYYQQEQVNKSHKAQLAIGHKLEDFQ","202496","","conserved hypothetical protein","Extracellular","One weak hit in gapped BLAST. Residues 28-86 are 38% similar to gi15485451 from S.thermophilus. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2012 (3e-24).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 6 12:57:36 2007","Tue Mar 6 12:57:36 2007","Tue Mar 6 12:57:36 2007","Wed Jan 2 15:36:07 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0184 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:38:24 2002","","No significant hits to the NCBI PDB database.","SMU.205c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:36:07 2002","24378716","","","","","","1","","6","SMU.205c","" "SMu0185","203269","202868","402","ATGGAGTTGAGTTTGAAGAAATTGTTAGACAGATATAAACCTATTAATGTGCCCGAAAAATTTAATCGTCCTATTCAGCGGAGACATTTTATGACTGGTTATGAAGAATTACATTTATCCTTTTATGATTTTGAGTTGGTTAAGGGGTTTATTGATTATTGGGGGTTGCTTTATATTTTGCCTAAAAAAGATTCTGGATTGAAATATGTGAAGCTTTTTAGAGGTAAGCAATTTAAAAGTGAGGAACACCGTCAGAATGCTATTGAAAAGGCTGCTAGACAAGAAGCTAGGCAGCCTTTTTTTGATGAATTGAAAACGAAACCTCTTAAACAGATGAGTGAGAATGCTCGGTGGGTTGCAGAGTTATTGGTTAAGTTAGGTTATGCAGAATTGGTGTTGTAG","10.40","7.72","15952","MELSLKKLLDRYKPINVPEKFNRPIQRRHFMTGYEELHLSFYDFELVKGFIDYWGLLYILPKKDSGLKYVKLFRGKQFKSEEHRQNAIEKAARQEARQPFFDELKTKPLKQMSENARWVAELLVKLGYAELVL","202871","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0185 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:38:48 2002","Wed Jan 2 15:37:10 2002","Wed Oct 9 17:38:48 2002","Wed Jan 2 15:37:10 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0185 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:38:48 2002","","No significant hits to the NCBI PDB database.","SMU.206c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:37:10 2002","24378717","","","","","","1","","6","SMU.206c","" "SMu0186","204464","203232","1233","GTGCTTAGTCATGCAGATTTGAAGCGGATTAGGCTTGAGTTAGGTTTTACCCAGCGTAAGATGGCCGCTATTATTGGTTATAGCTATTTTAATTATCGTAATATTGAGCAGGGTCAACGAAAAATTACAAAAGAGTTTGAAGAAACGCTGTTTCATTTTTTGAATCGAAAATCAGAAACAAAGTTGGAAGGCTCTGTTGACTGGCTGAAGATTAGGTTTAAAACATTAGATTTTAAGATGGTTATAACGAAAGTACTTAAGTTAAAGCCAGCAGATTTTTTTCTGGAAGAGAAAAGTCTATATAGTTATCGGTATATGGTAACTTATGGTGCCATTCGAATATTGTATTCGGATTCTAAGAAGAAGGCAGAATCTGGAACATTAATTGATTTGACAGGCGGTGGATGTCGTGAATTGGAATTGATTTTGATAGAACAGGGGCGTGATTGGTTTAGTTTTTTACATGATGTTTTTCTCTTTGCAGAACAAGAGCGAAAAGATAGACTTTTGGAAGATTTTTTAGCTTTTCCGCGCTTTGATATTGCTTTAGATGAACTTTATAAGGAAACAGGAAATCTTGATTTGTTTGATATCAAAGCTCGTGTTTTTGATAATAAAATCATTATGAAAAGAACGCGTACTTTTACAGCAATTGAAGGGTTGAAAAAAGTGGATGGGCGTTTTGTGAATCAAGGGTTAACGTTAAACTTTGGTAGTCGTCAATCTGCTTTGATGATTCGGTTTTATCAAAAGGATTATGAGCAAGCTCTTTTGAAAGATGTATCGGTAGATTATATTCATGAAGTTTATAATTTAAAAAATCGTTATGAATTGGAGTTACATGATACGAAAGCTTTTGATGTTTTGAAAGAGTGGTACACTATGGAAACTGATTTAACCCAAATTGGGGCTCGAATACTTAATAATTATTTTGAAGTTAAAGATTGGAATGGTAAGTATGATAGTGAGTGGGATGGTTTGCTTGGAACGCAAGCAGGTTTTAAATTTGTGGTAAGACCTCGTCAAATTGACTATGCAAGAACGAAGTATTGGGTGACTAGGCAAGTTTCGAGTGCTCTTAAGTTGCTTAAAATTGCAGATGTTGTTTTTAAGAGAGATGAGCTATCAGAGATTATTTCAGAAGCCTATCTTAGTAAGAATCATGCAAAATTAGCTGAGGAGATTTGTCAGAGAAATGGAGTTGAGTTTGAAGAAATTGTTAGACAGATATAA","8.90","4.40","48469","MLSHADLKRIRLELGFTQRKMAAIIGYSYFNYRNIEQGQRKITKEFEETLFHFLNRKSETKLEGSVDWLKIRFKTLDFKMVITKVLKLKPADFFLEEKSLYSYRYMVTYGAIRILYSDSKKKAESGTLIDLTGGGCRELELILIEQGRDWFSFLHDVFLFAEQERKDRLLEDFLAFPRFDIALDELYKETGNLDLFDIKARVFDNKIIMKRTRTFTAIEGLKKVDGRFVNQGLTLNFGSRQSALMIRFYQKDYEQALLKDVSVDYIHEVYNLKNRYELELHDTKAFDVLKEWYTMETDLTQIGARILNNYFEVKDWNGKYDSEWDGLLGTQAGFKFVVRPRQIDYARTKYWVTRQVSSALKLLKIADVVFKRDELSEIISEAYLSKNHAKLAEEICQRNGVEFEEIVRQI","203235","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transpososn fragments. Residues 2-378 are 28% similar to gi15485448, a putative transfer protein from S.thermophilus. Residues 6-394 are 28% similar to gi15923398 from S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2017 (6e-39).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[7-62]T$	HTH_3
SM00530	$\"[6-61]T$	HTH_XRE
PS50943	$\"[7-62]T$	HTH_CROC1

InterPro
IPR003491
Family

Replication initiation factor
PF02486	$\"[174-398]T$	Rep_trans

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 132-315 are 27% similar to a (PROTEOME COMPLETE ORF20 YDCR) protein domain (PD011258) which is seen in P96635_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 26 11:07:17 2006","Tue Mar 6 13:14:59 2007","Tue Sep 26 11:07:17 2006","Wed Jan 2 15:40:16 2002","","Wed Jan 2 15:40:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0186 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:39:22 2002","","No significant hits to the NCBI PDB database.","SMU.207c","","Residues 7 to 62 (E-value = 2.5e-05) place SMu0186 in the HTH_3 family which is described as Helix-turn-helix (PF01381)Residues 174 to 398 (E-value = 4.4e-05) place SMu0186 in the Rep_trans family which is described as Replication initiation factor (PF02486)","Tue Sep 26 11:07:17 2006","24378718","","","","","","1","","6","SMU.207c","" "SMu0187","206423","204699","1725","ATGGTGAGAAAGCTTTTTTATTGGGTAGTTCATGATATTTATACTTATAAAGGGAAACGTGTTAGAAATTGGTATAAATATAGCAGGAGCTTTCAGATAGGTTTCTTTTTCTTACCTTTTTTAGCTGCTGTTGGTTTATTTCTTTATTATCATTACCTTCAGCTTTTACAATCTCCTCTTTTGTACTTAACTGGTTCTTTTACTGTTTTATTGCTGGCTTTAATATGTGTCATTATCATTGTGTTGAAATTAGAAGTTCATGTGCTTTGGTTTGCTCGACTGCGTTCATTGTTTTTGTTACGTCGTTTTTTGATTAGTCATAATTATTATGAAACAAAAGAAAGAACAGTACAGAGAGAGAAACGGACGGTTACTAAAACTAAGATTGTTTTGCCTAAGGTTTATTTGAAACAAGGAAAATTTGGGGTAGATGTTTATTTTGAATTGCAAGGAAATGCTTATCAAGAAAAGTTTTTGAAGCTTGGGCCAGAGTTAGAAACAACTTTTGGCGGTGATTTTATGTATCGAAAAGAAATTAAAGGCTATACTTATTATCACTTAGCTATTGATCGTTTTTCATCTCGGTTAAATGTTGTTGATGTTAAAGTAGATAAAAAAGGGTTACGCTTGATGAAAGATGTTTGGTGGGATTTTGATTCCCAACCTCATATGCTTGTGGCTGGTGGTACTGGTGGCGGTAAAACGGTTTTATTGATGGCTATTGTTTTAGGTTTAGCAGAGGTGGCAGATGTTGATTTGTGTGACCCTAAGGAGTCAGATTTAACAGTATTGAAAAAAGCACCTGTTTTTAAAAATCGGGTATTTTATAGTAAAGAGGATATGGTTGCATGTCTAAGAGATAATGTGGCTTATATGGTTGAGCGTTACCATTTTATGGCAAACCATCCAGATAATCGTATTGGGAAAAAATATTCAGATTATGGTTTGCGTCCTAAGTTTATTATTTTTGATGAATGGGCTGCATTTATGGCATTATTAGATGATAATATGAAGTTATCTATGGAAGTTGTACAGCTGTTGACTCAGTTAATTTTAAAGGGCCGTCAAGCCGGTATTTTTGTGATTGAAGGCCTGCAGCGCCCTGATGGTGAATTTATTAAAACGGCTTTGAGGGATAACTTTATGGTTCGTGTGTCTGTTGGTGTACTTGAAGATACGGGTTATACTATGCTTTTTGGAGACGCTAACCGTAATAAGATTTTTAAAAATATTGATGAAGTTAATGGTGAAAAGGTTAAAGGTCGTGGTTATTTTGCACATGCTGGTACAATGGCTGGTGAGTTTTTTGCGCCATTTGTACCTTTTGATAAAGGGTTTGATTTTTTGGAGGCTTTTGAAGCTATGCCTGTATTGCCTGATGATCTTGTCGCTTTTCCTGTTGCTAGTACTGCTGAGGCATTGGAAGAAGCTAAGGAATTGCCAGTTGATACTGTGTTTGAACAATTACCTAAAAAACATGAGACTTTGGATAGTCTAGCTAAGCGTTTAGCTAAGAGTTTTAATCAAGTTAAAAATGTTGTGACTATGATTGAAGATGGCGATTATTATACGTTTGCTCGTGATGATGCCGGTAAATATAGTTTTACAGGTGTTGAGTCAGATATGATTATTGCTATTTTTGAGGCAAAAGAAGCTAGTGACCAGCGTTATAAGACTGTTATTGCTGACTTTTTTAATACTTCTACTGAAGATGAAGCTGCTTAG","8.00","3.32","66079","MVRKLFYWVVHDIYTYKGKRVRNWYKYSRSFQIGFFFLPFLAAVGLFLYYHYLQLLQSPLLYLTGSFTVLLLALICVIIIVLKLEVHVLWFARLRSLFLLRRFLISHNYYETKERTVQREKRTVTKTKIVLPKVYLKQGKFGVDVYFELQGNAYQEKFLKLGPELETTFGGDFMYRKEIKGYTYYHLAIDRFSSRLNVVDVKVDKKGLRLMKDVWWDFDSQPHMLVAGGTGGGKTVLLMAIVLGLAEVADVDLCDPKESDLTVLKKAPVFKNRVFYSKEDMVACLRDNVAYMVERYHFMANHPDNRIGKKYSDYGLRPKFIIFDEWAAFMALLDDNMKLSMEVVQLLTQLILKGRQAGIFVIEGLQRPDGEFIKTALRDNFMVRVSVGVLEDTGYTMLFGDANRNKIFKNIDEVNGEKVKGRGYFAHAGTMAGEFFAPFVPFDKGFDFLEAFEAMPVLPDDLVAFPVASTAEALEEAKELPVDTVFEQLPKKHETLDSLAKRLAKSFNQVKNVVTMIEDGDYYTFARDDAGKYSFTGVESDMIIAIFEAKEASDQRYKTVIADFFNTSTEDEAA","204702","","conserved hypothetical protein, FtsK/SpoIIIE family","Cytoplasm, Membrane","Matches in gapped BLAST to transposon fragments and FtsK-like DNA segregation ATPases. Residues 105-505 are 49% similar to gi15485447, a putative transfer protein from S.thermophilus. Residues 106-469 are 36% similar to gi16077553 from B.subtilis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2018 (2e-80).","

InterPro
IPR002543
Domain

Cell divisionFtsK/SpoIIIE
PF01580	$\"[184-370]T$	FtsK_SpoIIIE
PS50901	$\"[211-396]T$	FTSK

noIPR
unintegrated

unintegrated
PTHR22683	$\"[214-385]T$	PTHR22683
PTHR22683:SF1	$\"[214-385]T$	PTHR22683:SF1
SSF52540	$\"[170-453]T$	SSF52540

","BeTs to 8 clades of COG1674COG name: DNA segregation ATPase FtsK/SpoIIIE and related proteinsFunctional Class: DThe phylogenetic pattern of COG1674 is --------eBRhUJ--olinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 222-390 are 42% similar to a (COMPLETE PROTEOME CELL DIVISION) protein domain (PD002076) which is seen in P96634_BACSU.Residues 222-285 are 43% similar to a (ORF21) protein domain (PD265097) which is seen in Q47727_ENTFA.Residues 105-219 are 26% similar to a (PROTEOME COMPLETE ORF21 YDCQ) protein domain (PD037669) which is seen in Q47727_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:40:05 2002","Tue Sep 26 11:14:51 2006","Tue Sep 26 11:14:51 2006","Tue Oct 8 08:15:33 2002","","Wed Jan 2 15:44:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0187 is paralogously related (blast p-value < 1e-3) to SMu1483, a predicted DNA segregation ATPase.","Wed Jan 2 15:45:49 2002","","No significant hits to the NCBI PDB database.","SMU.208c","","Residues 184 to 370 (E-value = 6.3e-20) place SMu0187 in the FtsK_SpoIIIE family which is described as FtsK/SpoIIIE family (PF01580)","Wed Jan 2 15:44:31 2002","24378719","","","","","","1","","6","SMU.208c","" "SMu0188","206864","206439","426","ATGACTTTGAAATATGCTGCTGATGTTATTGAAAAATTTGATCTTGATAAAACATTTGGAACACTTAATTTTTTAGAAACGGTTCCTATTATGAAATGGGAAGATTACCTTGATGAATCTACTGGTGAAGAAAAGCGTCGTGAAACAGATGAATTAGAAGCATTAGATGTGAAAATTTACTCTTCTGCTGCTGGTGGAATCATTACAGTTACAGTACCGCCTGAAGCTAAAGTGATTCAGTTGACACCTGAAAAAAATTATAATGATGAAGTTAAGCTTGTAGCTCCTACAGCTCGGTTTTGGTCTAATTCAGAGGTGATTAATGGCCGTCGTGTTGTGACTAGTGGTGTTAAGATTCGAGCAAAAGATGTTGTTGTGTCTAATGTAGGTAAATCTAATACTAAAGAGATTAAACCAGATAAGTAA","5.00","-3.00","15778","MTLKYAADVIEKFDLDKTFGTLNFLETVPIMKWEDYLDESTGEEKRRETDELEALDVKIYSSAAGGIITVTVPPEAKVIQLTPEKNYNDEVKLVAPTARFWSNSEVINGRRVVTSGVKIRAKDVVVSNVGKSNTKEIKPDK","206442","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0188 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:40:28 2002","Wed Jan 2 15:46:56 2002","Wed Oct 9 17:40:28 2002","Wed Jan 2 15:46:56 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0188 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:40:28 2002","","No significant hits to the NCBI PDB database.","SMU.209c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:46:56 2002","24378720","","","","","","1","","6","SMU.209c","" "SMu0189","207199","206888","312","ATGGAAATTACTAAAGTATTTGTTGACCAAAATGAGGTTTTAGGAAATGATGTTTTCGTATCTGGTATGGAAGAAGTCAGGGCTAATGATTATAATCCTGTCTCTTATCGTGTTTTTGAAATTTCCAGTCGTAAAGAGCCCTCTGCTTTTTTAATTGTAGAAGGGTTTAAAATGTCTGATGTCCCTGAAGGGCGTCAAAAGGTTATTTTCCCTCGTGGGATTAGGATTGAACGACGTCATTTTCGTTTTGGAGGCAAACGTAAACATGAAAATGTCATTGTAGCGGAAGAAATGCGTGTAATTAAAAATTAA","9.90","2.48","12014","MEITKVFVDQNEVLGNDVFVSGMEEVRANDYNPVSYRVFEISSRKEPSAFLIVEGFKMSDVPEGRQKVIFPRGIRIERRHFRFGGKRKHENVIVAEEMRVIKN","206891","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0189 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:40:50 2002","Wed Jan 2 15:47:59 2002","Wed Oct 9 17:40:50 2002","Wed Jan 2 15:47:59 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0189 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:40:50 2002","","No significant hits to the NCBI PDB database.","SMU.210c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:47:59 2002","24378721","","","","","","1","","6","SMU.210c","" "SMu0190","207862","207419","444","ATGAAGAGGAATTTTATAAAGGGCGAGTATAAAGAAGAAAAATGTTTTAAAAAGTCTTTAACTGAGAAACAGAAGTTTGTTGTGAGAAGCTATGGTTTGATAGCAGGCGGGCCGTTGATATTTGCAATAGTACTAGTTATACCTCGGTTTGTTTCTTATGTGATTGATAAACTTGGTAGTGATGAGGAACAGTTAAGTGCTATAGAGAAATCAGGTTCTGTTGTTTGGGCTTGGGGTGAAAATATTCTATCTTCTATTTCTACAATTATATTTTATACTTCTTTTAGTGTAGCTGTTTCATTTACTTTTGCTTTATTGATGGTTGCTTTAAGTGGGGGAAAATATAGTGATGATGAGTATAAATTTTTTGTTAAATCATGTACGGTTATTGTTTTTTTGAGCTTTCTTTTTGGAATGATAATTTTTGAATATATTTTGAATTAA","8.60","1.90","16613","MKRNFIKGEYKEEKCFKKSLTEKQKFVVRSYGLIAGGPLIFAIVLVIPRFVSYVIDKLGSDEEQLSAIEKSGSVVWAWGENILSSISTIIFYTSFSVAVSFTFALLMVALSGGKYSDDEYKFFVKSCTVIVFLSFLFGMIIFEYILN","207422","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu0190 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[31-51]?$ $\"[88-110]?$ $\"[122-142]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[5-25]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:42:04 2002","Wed Jan 2 16:00:10 2002","Wed Oct 9 17:42:04 2002","Wed Jan 2 16:00:10 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0192 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:42:04 2002","","No significant hits to the NCBI PDB database.","SMU.213c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 16:00:10 2002","24378724","","","","","","1","","6","SMU.213c","" "SMu0193","208663","208355","309","ATGGATTTTAAAGAAAAAGTTAAGTTGTGGTTTAATCGTTATCGTCTGCGATTGGCATTAAAAAATGCTTCTAAGAATAATTATATTTCTTTTCATTATGATTCAGAAGGTGTTATTTTTGTTCAGTCTGGTAAAAGGTATGATACTTGTTTTGGTTTATCAGTGTCTGATGTTGATTTGGCAGTTTTTGAAAAATATATTGTTAGTGGTGAATTTTTAGTTTATCAAGGAATTTGGCGGTCTCCTTTGGTTGACTATATTTTACGTTTTTTAAGCAAATGGGGAAAAGTTGATATTTGGCGTGTTTGA","10.20","5.18","12157","MDFKEKVKLWFNRYRLRLALKNASKNNYISFHYDSEGVIFVQSGKRYDTCFGLSVSDVDLAVFEKYIVSGEFLVYQGIWRSPLVDYILRFLSKWGKVDIWRV","208358","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0193 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:42:26 2002","Wed Jan 2 16:01:14 2002","Wed Oct 9 17:42:26 2002","Wed Jan 2 16:01:14 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0193 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:42:26 2002","","No significant hits to the NCBI PDB database.","SMU.214c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 16:01:14 2002","24378725","","","","","","1","","6","SMU.214c","" "SMu0194","208872","208672","201","ATGAATGGTGTTTGTTTTGTTTATCCAGTTATACTTGATGGAGAAGGTGTTTGGAAAATGAGTACTGGAATTGCTGATTTAGGTGGTTATCCTTTTTGTCTTGCGACAGTGGATCATTTACCAGAAGGTTTATCAGTTACTGATTATGAGCGAGTACAAAGATTGGTGAGTCAGTTTTTATTAAATAAGGAAGAAAGGTAA","4.40","-3.87","7361","MNGVCFVYPVILDGEGVWKMSTGIADLGGYPFCLATVDHLPEGLSVTDYERVQRLVSQFLLNKEER","208675","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0194 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:42:47 2002","Wed Jan 2 16:02:20 2002","Wed Oct 9 17:42:47 2002","Wed Jan 2 16:02:20 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0194 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:42:47 2002","","No significant hits to the NCBI PDB database.","SMU.215c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 16:02:20 2002","24378726","","","","","","1","","6","SMU.215c","" "SMu0195","209266","208952","315","GTGCAAAAGAGTGTTTATGTAGATGATCCAAAGATTATTGTTTATCCTAGCTTTTATGGTGTTAAAGTGAGTACTGAAGGTGATGAGAGAATAAAAGTGTCTTCTTTATATCCATTTACAACGAGTTTAAATGAAGATTGTAAAGAAGCATTAAAAGAATTTATTGTTGATTTTAAAGAGGAGCTAAAGTTGTATTATCAGGCTAGTGGGAAGTATAAAACTAAATCTTTAACAACTATGCTTTTTGGGTTTGATACGGAATTGAAGGAAAAGTTTAAGGATAAGTGGTTTAAACGTGGGGTTGTACTAAATTAG","9.10","1.94","12142","MQKSVYVDDPKIIVYPSFYGVKVSTEGDERIKVSSLYPFTTSLNEDCKEALKEFIVDFKEELKLYYQASGKYKTKSLTTMLFGFDTELKEKFKDKWFKRGVVLN","208955","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0195 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:43:08 2002","Wed Jan 2 16:03:18 2002","Wed Oct 9 17:43:08 2002","Wed Jan 2 16:03:18 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0195 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:43:08 2002","","No significant hits to the NCBI PDB database.","SMU.216c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 16:03:18 2002","24378727","","","","","","1","","6","SMU.216c","" "SMu0196","209913","209386","528","ATGATAGAGGGATATTCAATTATGGATTGGCTTACTTTAAGTGGTGTTGTAGCAACTATTGGAGCGATTATAGGAGTTCTTATTACAAATTCTAGAGATAATAAAGGGTTATCTAAAGAACATGATGGGTTGGCTAAAGAACATGAAGATTTAGAGAAGAAAATTTCTAGTGAGGCTAAATCTATTAAAAATGATACGACATATATTCGAGATGAAATGTTGGCTGAAAAAATAGCTCGTCAAAGTTTGTATCAAAATACGTCTCGTGCAAAAGAGATATTGGAGACGATAGACATTATGGAAGAGGTTGTTCATCAGAATGCTGCCCTTCATGCTGAAATATCAGATTTAAAAGTTAAAAATCAAGAGCTTTTAGATAGAAAACAAAGCGATAACTCATCGAAATTACTTCATGCTATTAATCAATTTGATCGAAAATTAGGTGGGTTTGAAATGTATAGTGAATCAGAAGAAATTCATGCTATTTTAAAGAAAATCACAAATGAATTATCTGAGTATCTTAATTAA","5.10","-7.54","19817","MIEGYSIMDWLTLSGVVATIGAIIGVLITNSRDNKGLSKEHDGLAKEHEDLEKKISSEAKSIKNDTTYIRDEMLAEKIARQSLYQNTSRAKEILETIDIMEEVVHQNAALHAEISDLKVKNQELLDRKQSDNSSKLLHAINQFDRKLGGFEMYSESEEIHAILKKITNELSEYLN","209389","","conserved hypothetical protein; Streptococcus-specific protein","Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1995 (2e-23).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[10-28]?$	transmembrane_regions

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[6-60]T$	HTH_3
SM00530	$\"[5-60]T$	HTH_XRE
PS50943	$\"[6-60]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[1-64]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[1-64]T$	G3DSA:1.10.260.40

","BeTs to 5 clades of COG1396COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1396 is --T--qV-EBR---------xNumber of proteins in this genome belonging to this COG is 6","No significant hits to the Blocks database.","Residues 1-61 are 47% similar to a (COMPLETE PROTEOME REGULATOR) protein domain (PD000418) which is seen in XRE_BACSU.Residues 6-63 are 39% similar to a (REPRESSOR COMPLETE PROTEOME) protein domain (PD027337) which is seen in Q9EUV6_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 16:46:45 2002","Tue Mar 6 13:23:52 2007","Tue Mar 6 13:23:52 2007","Tue Oct 8 08:17:06 2002","","Wed Jan 2 16:07:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0197 is paralogously related (blast p-value < 1e-3) to SMu1842 (previously published in GenBank), SMu0737, SMu0717, SMu0366, SMu0056, and SMu1275, hypotheticals and predicted transcriptional regulators.","Fri Jan 11 16:43:25 2002","","No significant hits to the NCBI PDB database.","SMU.218","","Residues 6 to 60 (E-value = 1.8e-17) place SMu0197 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Wed Jan 2 16:07:39 2002","24378729","","","","","","1","","6","SMU.218","" "SMu0198","211020","211451","432","ATGAACTTATCAAAAATTGTTAGAGATACAGAAAAACTTGGAGTTACCATCATTTTCTGTCCTTTCAAAAAAGAAAAAGGCAGACACTTAGTCACCTCTAACACCAAATTTATTTTGATAAATGAAACCTTATCCGACACTGAGAAAATCAATGTTATCCTACATGAAATAACCCATTTCATTAACAAAGATACAGGAAATATTTTAAGCCAAAGCAACACTTTTGCCCATTATATTGAGAAAGAAGCAGAAGTAGAACGAATTATTAATTTCATGAATTTAATCAATGATGAATATCCGATTGACGAAAGTTTTAACTACCTTGATTATATGCATAAAGCTTTCATACCCGAAAAATATGAAAACATTGTTAAAGAAGAAGCTAAAAAACTCTACCAAAAAAATAAAATAAAATTGACAAAACCAAAATAA","8.40","2.15","16865","MNLSKIVRDTEKLGVTIIFCPFKKEKGRHLVTSNTKFILINETLSDTEKINVILHEITHFINKDTGNILSQSNTFAHYIEKEAEVERIINFMNLINDEYPIDESFNYLDYMHKAFIPEKYENIVKEEAKKLYQKNKIKLTKPK","211448","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu0198 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006025
Binding_site

Peptidase M, neutral zinc metallopeptidases, zinc-binding site
PS00142	$\"[52-61]?$	ZINC_PROTEASE

InterPro
IPR010359
Family

Protein of unknown function DUF955
PF06114	$\"[10-132]T$	DUF955

noIPR
unintegrated

unintegrated
signalp	$\"[1-34]?$	signal-peptide
tmhmm	$\"[10-30]?$	transmembrane_regions

InterPro
IPR002104
Domain

Integrase, catalytic core, phage
PF00589	$\"[1-168]T$	Phage_integrase

InterPro
IPR013762
Domain

Integrase-like, catalytic core, phage
G3DSA:1.10.443.10	$\"[1-168]T$	no description

","BeTs to 10 clades of COG0582COG name: IntegraseFunctional Class: LThe phylogenetic pattern of COG0582 is aMtK-qvcEBRHUJ---LINXNumber of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 124-177 are 48% similar to a (INTEGRASE COMPLETE DNA PROTEOME) protein domain (PD000437) which is seen in Q38086_VVVVV.Residues 5-105 are 32% similar to a (INTEGRASE PROTEOME COMPLETE DNA) protein domain (PD009586) which is seen in Q9K722_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 26 16:43:01 2006","Tue Sep 26 16:43:01 2006","Tue Sep 26 16:43:01 2006","Tue Sep 26 16:43:01 2006","","Wed Jan 2 16:15:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0200 is paralogously related (blast p-value < 1e-3) to SMu0172, and SMu0942, phage and transposase related integrases.","Wed Jan 2 16:16:30 2002","","No significant hits to the NCBI PDB database.","SMU.221c","","Residues 1 to 168 (E-value = 7.5e-07) place SMu0200 in the Phage_integrase family which is described as Phage integrase family (PF00589)","Wed Oct 9 17:45:20 2002","24378732","","","","","","1","","6","SMU.221c","" "SMu0201","213704","213510","195","ATGGCAATTTCCTATAGACAGCGAGGAAAAAAGAAATTATGGGATTATAGAGTCTTTGATAGTAACAAAAAAGTAATTGCCTCTAATTCTGGCTTTAAAACGAAAAAAGAAGCTGAATCGGAGGCACTTTATTTAGAAATGAAACTAAAAAATGGAACTATCATTGATAGAAATATTACTTTATACCAGCTATAG","10.70","6.98","7514","MAISYRQRGKKKLWDYRVFDSNKKVIASNSGFKTKKEAESEALYLEMKLKNGTIIDRNITLYQL","213513","","hypothetical protein (possible integrase fragment)","Periplasm, Extracellular","No significant matches in gapped BLAST, however residues 4-62 are 40% similar to a sequence from Streptococcus thermophilus temperate bacteriophage 01205 (gi|7444574).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1993 (4e-15).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:45:55 2002","Wed Oct 9 17:45:55 2002","Fri Jan 4 11:12:33 2002","Fri Jan 4 11:11:52 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0201 is paralogously related (blast p-value < 1e-3) to SMu0172, a phage-related integrase.","Fri Jan 4 11:12:33 2002","","No significant hits to the NCBI PDB database.","SMU.222c","","No significant hits to the Pfam 11.0 database","Fri Jan 4 11:11:52 2002","24378733","","","","","","1","","6","SMU.222c","" "SMu0202","213856","213755","102","GTGAAATATCCTAATTCTCAAGGTGGCAAATATTTATTTTTAGCTTCTAAGACTAAAGAATATTTTAAAAGCCATTTTAGAGAAATTATGATTGACGTATGA","10.40","3.22","3908","MKYPNSQGGKYLFLASKTKEYFKSHFREIMIDV","213758","","hypothetical protein","Extracellular, Cytoplasm","No significant matches in gapped BLAST.SMu0202 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","BeTs to 3 clades of COG1759COG name: ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases)Functional Class:� RThe phylogenetic pattern of COG1759 is AmtK-----------------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:46:25 2002","Fri Jan 4 11:13:43 2002","Wed Oct 9 17:46:25 2002","Fri Jan 4 11:13:43 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0202 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:46:25 2002","","No significant hits to the NCBI PDB database.","SMU.223c","","No significant hits to the Pfam 11.0 database","Fri Jan 4 11:13:43 2002","24378734","","","","","","1","","6","SMU.223c","" "SMu0203","214355","213906","450","ATGCAGGATGGCTATATTAATTCTTTATATTGGCTCAAAGTAAAGCACCCAAATGCTAATAAGGGAGATGCCATTACATTCATAAAGAATCACGTCGCTTGTGATTATACTGTATCCTTTGGAAATGAAACAAATATTATTGAAATGTTTCTAGCTAGTGATATAAGCATTTGTGTTGTAAATGCTTATAATGTGATAAAAGATATTGCTGATTATGGGAAAATCAGTATTACGATAGCAGATGATATTTTAGAGTTGTTTGAAAAGGAATATCATAGGTATTTAGAAAATGTTGTTATTGCTCTACCAGAAGATAAAATCATTATAGAAAAGTCTGAATATGATGCTTTGAAAAAACGGGACACTCAAGGTCGTTATATGTCCATGAATGAGCTTTTAGAGCTTCTTTCAGTCAGTCGGTCCTTGGTTCATAGAAAATGTTCTCTATAA","5.30","-4.18","17113","MQDGYINSLYWLKVKHPNANKGDAITFIKNHVACDYTVSFGNETNIIEMFLASDISICVVNAYNVIKDIADYGKISITIADDILELFEKEYHRYLENVVIALPEDKIIIEKSEYDALKKRDTQGRYMSMNELLELLSVSRSLVHRKCSL","213909","","hypothetical protein","Cytoplasm","No significant matches in gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1105 (3e-05).","

InterPro
IPR008489
Family

Protein of unknown function DUF771
PF05595	$\"[97-121]T$	DUF771

noIPR
unintegrated

unintegrated
SSF56784	$\"[3-72]T$	SSF56784

","BeTs to 4 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class:� RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:46:45 2002","Fri Jan 4 11:14:54 2002","Wed Oct 9 17:46:45 2002","Fri Jan 4 11:14:54 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0203 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:46:45 2002","","No significant hits to the NCBI PDB database.","SMU.224c","","No significant hits to the Pfam 11.0 database","Fri Jan 4 11:14:54 2002","24378735","","","","","","1","","6","SMU.224c","" "SMu0204","214449","214336","114","TTGTTTATTTCATTCGTTGATTGCATTCAAAATATTGAAAAAATCGAAAAAGAACTTCTAAAGATTGGAATAACTGATATCCAAATTAATCAGGATGCAGGATGGCTATATTAA","4.10","-3.07","4307","MFISFVDCIQNIEKIEKELLKIGITDIQINQDAGWLY","214339","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST.SMu0204 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:47:06 2002","Fri Jan 4 11:15:59 2002","Wed Oct 9 17:47:06 2002","Fri Jan 4 11:15:59 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0204 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:47:06 2002","","No significant hits to the NCBI PDB database.","SMU.225c","","No significant hits to the Pfam 11.0 database","Fri Jan 4 11:15:59 2002","24378736","","","","","","1","","6","SMU.225c","" "SMu0205","215092","214544","549","ATGACCGAGCCATTCCATCAGGATGATATGGTGATCAGGGATAGCTTTCCCATACCTGTTTGTTTACCAGCTCGCAACGACAAGGTTCGTAGTTTTAGAGATCAAGCAACTGTGGCCTACAATCCTCCAAAAAAGATGTGCTTTTACGGCTTTAAAGCCCATATGCTGGTGACCTTGTCAGGATTTATTGTCAATTATGGTGTGACGCCAGCCTCTGTACATGATCGTCAGGTAGCCGAAGACCTGCTTGAGAACACAACTTTCCCTGTTGTTTTAGCGGACTTAGGTTACCTCAGTAAGGTTTTGAAACAGCATTTAACCCGGAAAGACTACCGTTTTTGGACACCCTTGAGGCGCAACATGGTCATGGTAAAGGCTAAACAACATAATCATTGGAGGCTCAAGGCTGAAAGGAGAACCATTGAAACGCGATTTTCAGTTTTATGTTCTGAGTTTGACATCGAAAGGCCATTAGCGAGAAGTTTAAAGGGGTTGAAGCTTTGGTTAGAGCAGACTATCTTTGCCTATAACCTAGGATTTTTTTACTAG","10.40","10.29","21389","MTEPFHQDDMVIRDSFPIPVCLPARNDKVRSFRDQATVAYNPPKKMCFYGFKAHMLVTLSGFIVNYGVTPASVHDRQVAEDLLENTTFPVVLADLGYLSKVLKQHLTRKDYRFWTPLRRNMVMVKAKQHNHWRLKAERRTIETRFSVLCSEFDIERPLARSLKGLKLWLEQTIFAYNLGFFY","214547","","transposase, IS1216, also reported on plasmid, truncated","Cytoplasm","This sequence was previously published in GenBank as gi13897502, a predicted transposase. Similarities also to gi15383627 and gi6716559, predicted transposases from S.criceti and S.agalactiae respectively.SMu0205 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002559
Domain

Transposase, IS4-like
PF01609	$\"[10-178]T$	Transposase_11

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 14-178 are 60% similar to a (TRANSPOSASE PLASMID PROTEASE TRASNPOSASE) protein domain (PD013353) which is seen in Q9L9Q9_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:47:41 2002","Tue Sep 26 17:02:58 2006","Tue Sep 26 17:02:58 2006","Fri Jan 4 11:21:25 2002","","Fri Jan 4 11:21:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0205 is paralogously related (blast p-value < 1e-3) to SMu0095, SMu1213, SMu0083, and SMu0084, all predicted transposase fragments.","Fri Jan 4 11:32:15 2002","","No significant hits to the NCBI PDB database.","SMU.226c","","Residues 10 to 178 (E-value = 5.6e-21) place SMu0205 in the Transposase_11 family which is described as Transposase DDE domain (PF01609)","Fri Jan 4 11:21:25 2002","24378737","","","","Tue Sep 26 17:02:58 2006","","1","","6","SMU.226c","" "SMu0206","216404","215841","564","ATGATCCATCATCAAAGCACCATCATCTACTGTTTATTAGTTCTGTGGGGATTAACAGAATGGTTTATTAAAAGCAGAACCAAAAAGAATGTCTCTAATAGTTCTCAGGATAAAGGAACAAGATATGTTATTATTGCCAGTGTTGTGCTTTCTATAGCTATGTTAAATAATCCTTTTAACATTAATATACTTCTACCAGAATGGGGAATTTATCTAGGCATTTTGTTAATGATCCTTGGTATTATCTTTAGGGTATATGCTATCAATTATCTTGGTAAAGCATTTACGTTAACCGTTCAAGCTACCGACAATCAGAAATTAATCAGCAGCGGACCTTATAGTATTGTCCGTAACCCTGCTTATACTGGTACTATTATTTCGATTCTTGGTTTAGCCTTTATAACTTTAAATATTTTTAATATTTTAATAGTTTTTATCATCTTAAGTATTGGTTATGCTATCCGCATCCGAACTGAAGAAGAGGTTCTCGAACAACATTTCGGCAGGATATATCAAGATTATTGTCAAAAGGTTAAATATCGCCTTTTCCCATTTATTTGGTAA","10.30","7.61","21499","MIHHQSTIIYCLLVLWGLTEWFIKSRTKKNVSNSSQDKGTRYVIIASVVLSIAMLNNPFNINILLPEWGIYLGILLMILGIIFRVYAINYLGKAFTLTVQATDNQKLISSGPYSIVRNPAYTGTIISILGLAFITLNIFNILIVFIILSIGYAIRIRTEEEVLEQHFGRIYQDYCQKVKYRLFPFIW","215844","","conserved hypothetical protein","Membrane, Cytoplasm, Extracellular","Limited weak hits in gapped BLAST to gi|15921450, a predicted hypothetical from Sulfolobus tokodaii; residues 83-187 are 38% similar to residues 96-199 of this sequence. Residues 91-187 are 28% similar to a fragment of Sinorhizobium meliloti(gi|15965342).SMu0206 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001104
Domain

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
PS50244	$\"[73-149]T$	S5A_REDUCTASE

InterPro
IPR007269
Family

Isoprenylcysteine carboxyl methyltransferase
PF04140	$\"[71-165]T$	ICMT

InterPro
IPR010916
Domain

TonB box, N-terminal
PS00430	$\"[1-102]?$	TONB_DEPENDENT_REC_1

noIPR
unintegrated

unintegrated
PTHR12714	$\"[42-187]T$	PTHR12714

","BeTs to 5 clades of COG2020COG name: Putative protein-S-isoprenylcysteine methyltransferaseFunctional Class:� OThe phylogenetic pattern of COG2020 is a--ky--C--Rh---------Number of proteins in this genome belonging to this COG is 2","***** IPB001171 (Ergosterol biosynthesis ERG4/ERG24 enzymes) with a combined E-value of 1e-08. IPB001171F 93-135 IPB001171G 135-187","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:47:57 2002","Fri Jan 4 11:26:11 2002","Wed Oct 9 17:47:57 2002","Fri Jan 4 11:26:11 2002","Fri Jan 4 11:26:11 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0206 is paralogously related (blast p-value < 1e-3) to SMu0309.","Wed Oct 9 17:47:57 2002","","No significant hits to the NCBI PDB database.","SMU.227c","","Residues 71 to 165 (E-value = 1.8e-10) place SMu0206 in the ICMT family which is described as Isoprenylcysteine carboxyl methyltransferase (ICMT) family (PF04140)","Fri Jan 4 11:26:11 2002","24378738","","","","","","1","","","SMU.227c","" "SMu0207","216789","217154","366","ATGACGGTAAAAATTAATACAAAAGATGGTCAAATTGAATTGTCTAATGATGTGATCGCGACAGTCGTTGGCGGTTCAGCTAATGAGATCTTTGGAGTTGTTGGCATGGCAAGTAAAAGTGCCCTCAAGGATAATTTTCAAGCACTTCTGCGTAAGGAAAACTATTCTAAAGGTGTTGTCATAAAGTCGACAGATGCTGGTATTTCAGTTGATGTTTATACTGTGATGAGTTATGGTGTCAAAATTAGCGAAGTGTCAAAGAATATTCAAGAACGTGTTAAGTTTAACCTTGAAAATCAGTTAGGCATTACGGCTGATATGGTTAATGTTTATGTACAAAATATTAAAGTTGTGGGAGAAGATTAG","5.20","-1.01","13074","MTVKINTKDGQIELSNDVIATVVGGSANEIFGVVGMASKSALKDNFQALLRKENYSKGVVIKSTDAGISVDVYTVMSYGVKISEVSKNIQERVKFNLENQLGITADMVNVYVQNIKVVGED","217151","","alkaline-shock protein homolog","Cytoplasm, Extracellular","Several matches in gapped BLAST to alkaline-shock protein homologs and to hypotheticals. Residues 1-121 are 90% similar to gi15675703 from S.pyogenes. Residues 1-120 are 82% similar to gi15900359 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0130 (1e-57).","

InterPro
IPR005531
Family

Protein of unknown function DUF322
PF03780	$\"[8-116]T$	DUF322

noIPR
unintegrated

unintegrated
PD532004	$\"[3-116]T$	PD532004

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 10-116 are 70% similar to a (COMPLETE PROTEOME YBJK STRESS-LIKE) protein domain (PD332055) which is seen in Q9CJ15_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 3 16:16:35 2006","Fri Jan 4 11:27:11 2002","Mon Jul 3 16:16:35 2006","Fri Jan 4 11:27:11 2002","","Fri Jan 4 11:27:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0207 is paralogously related (blast p-value < 1e-3) to SMu1681, a conserved hypothetical.","Fri Jan 4 11:30:43 2002","","No significant hits to the NCBI PDB database.","SMU.228","","Residues 8 to 116 (E-value = 1.4e-52) place SMu0207 in the DUF322 family which is described as Protein of unknown function (DUF322) (PF03780)","Fri Jan 4 11:27:11 2002","24378739","","","","","","1","","","SMU.228","749" "SMu0208","217154","218821","1668","GTGGCTAATATTACAACAAGTTTATTCCAAGGAATGGTTCAGGCAGCAGCAACCCGTCTTGGTAAACAAGCAGAGTATGTCAATTCACTGAATGTCTTTCCTGTCCCGGATGGTGATACAGGTACTAATATGGGCATGACCATGGATAACGGTGCTAAGGAAGTTTCAGACAAACCAGCTTCTACGGTGGGTGAAGTTGGACAAATTCTTTCCAAAGGTCTTTTAATGGGGGCACGGGGAAATTCAGGTGTTATCACTTCTCAACTTTTCCGTGGTTTTGGTCAAAGCATTAAAAATAAGGAAGAATTAACGGGTAAAGATTTAGCGCAGGCTCTACAAGCAGGTGTTGAAGTCGCATATAAAGCAGTCATGAAGCCAGTTGAAGGGACTATCTTAACTGTATCGCGTGGTGCTGCGACGGCAGCTATTAAAAAATCTGAAAATACAGATGATACGGTTGAAGTGATGCAGGCGGCATTGGATGGAGCTAAAGCAGCACTGGCTAAGACACCGGATTTGCTTCCGGTTTTAAGGGAAGTTGGTGTTGTTGATTCAGGAGGTCAAGGTCTTGTATTCATTTATGAAGGCTTCCTATCAGCCTTGACAGGTGATTACATTATCTCAGAAGATTTTCAAGCGACACCTGCTAATATGACAGAAATGATTAATGCCGAACATCATAAATCTGTTGCCAGCCATGTTGCAACAGAAGATATTACTTTTGGCTACTGTACAGAAATTATGGTAGCGCTAAAACAAGGTCCTACCTATGTTAAAGATTTTAATTACGAAAATTTTCGTAATTATTTAAATAATTTAGGAGATTCTCTTTTAGTTGTCAATGACGATGAAATTGTTAAAGTTCATGTTCATACCGAAGATCCTGGACTTGTCATGCAAGAAGGCCTTAAGTATGGTGCCTTGGTTAAAGTTAAAGTGGATAACATGCGAAATCAACATGATGCTCAGGTGCAAAAGGAAAATACCACTGCTGATTTACCGCGAGAAGCGAAGAAATTTGGTATTATTGCAGTTGTCGCCGGTGAAGGTTTGGCAAAAATCTTTAAGTCACAAGGCGTTGATTATATCATCTCAGGTGGTCAGACAATGAACCCTTCTACAGAAGATATTGTTAAAGCGATTGAATCTGTTAAGGCTGAAAGTATCATTATTCTACCTAATAATAAAAATATTTTTATGGCTGCGCAGAGTGCAGCAGATGTTGTTGATGTTCCTGCAGCAGTTGTTGAGACTCGAACCATTCCACAAGGATTAACAAGTCTCTTGGCCTTTAATGCCGCAAATTCTCTTGAAGATAATCTTGTGGCTATGACAGAAAGTTTGACTGATGTTGTCAGTGGTAGTGTTACTAGAGCTGTTCGTGATACGACGATTGATGGCCTTGATATTCATAAAGATGATATTTTAGGTATGGTCAATGGAAAAATCCTTGTATCAAATCCAGATATGGATCAGGTCTTACATCAACTGTTTAAAAAAATGATTGCTGAAGATAGTGAAATTGTCACCATTTATGTTGGTGAAGAAGGTAGTCAAGAACAAGCGCAAAAATTAGCTGAAGATTTTGAAAATCAGCATGAAGAAATAGAAGTCGAGATTCATCAAGGAGATCAACCCGTTTATCCTTATTTGATGAGTGTAGAATAA","4.50","-31.58","59637","MANITTSLFQGMVQAAATRLGKQAEYVNSLNVFPVPDGDTGTNMGMTMDNGAKEVSDKPASTVGEVGQILSKGLLMGARGNSGVITSQLFRGFGQSIKNKEELTGKDLAQALQAGVEVAYKAVMKPVEGTILTVSRGAATAAIKKSENTDDTVEVMQAALDGAKAALAKTPDLLPVLREVGVVDSGGQGLVFIYEGFLSALTGDYIISEDFQATPANMTEMINAEHHKSVASHVATEDITFGYCTEIMVALKQGPTYVKDFNYENFRNYLNNLGDSLLVVNDDEIVKVHVHTEDPGLVMQEGLKYGALVKVKVDNMRNQHDAQVQKENTTADLPREAKKFGIIAVVAGEGLAKIFKSQGVDYIISGGQTMNPSTEDIVKAIESVKAESIIILPNNKNIFMAAQSAADVVDVPAAVVETRTIPQGLTSLLAFNAANSLEDNLVAMTESLTDVVSGSVTRAVRDTTIDGLDIHKDDILGMVNGKILVSNPDMDQVLHQLFKKMIAEDSEIVTIYVGEEGSQEQAQKLAEDFENQHEEIEVEIHQGDQPVYPYLMSVE","218818","","conserved hypothetical protein (possible kinase)","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 1-555 are 76% similar to gi15675702 from S.pyogenes and 74% similar to gi15902444 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0131 (0.0).","

InterPro
IPR004007
Domain

Dak phosphatase
PF02734	$\"[34-199]T$	Dak2

","BeTs to 4 clades of COG1461COG name: Predicted kinase related to hydroxyacetone kinaseFunctional Class: RThe phylogenetic pattern of COG1461 is ------v--br---gp-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 27-321 are 67% similar to a (COMPLETE PROTEOME MG369 YFHG) protein domain (PD025264) which is seen in Q9CJ16_LACLA.Residues 342-544 are 21% similar to a (PROTEOME COMPLETE) protein domain (PD400790) which is seen in P95121_MYCTU.Residues 339-555 are 21% similar to a (MG369 HOMOLOG G12_ORF558) protein domain (PD340490) which is seen in Y369_MYCPN.Residues 338-555 are 56% similar to a (PROTEOME COMPLETE YBJJ UU207) protein domain (PD018327) which is seen in Q9CJ16_LACLA.Residues 77-313 are 30% similar to a (PROTEOME COMPLETE) protein domain (PD416057) which is seen in Q9ZBR4_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:18:10 2002","Wed Oct 9 17:49:57 2002","Tue Jul 11 09:00:44 2006","Tue Oct 8 08:18:10 2002","","Fri Jan 4 11:35:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0208 is paralogously related (blast p-value < 1e-3) to SMu0606, a predicted ornithineacetyltransferase/N-acetylglutamate synthase.","Fri Jan 11 16:56:28 2002","","No significant hits to the NCBI PDB database.","SMU.229","","Residues 34 to 199 (E-value = 9.3e-78) place SMu0208 in the Dak2 family which is described as DAK2 domain (PF02734)","Fri Jan 4 11:35:50 2002","24378740","","","","","","1","","","SMU.229","21" "SMu0209","218987","220690","1704","GTGGAAAAAATATATCTTGAAAATCCTAAATCAGGATCAGAAATTCTTCTTGATACTTTGGCAAATTTAGGAGTAAAAACTATTTTTGGTTATCCTGGCGGTGCCGTCTTACCACTTTATGATGCTATTTATAAACAAGACAATATTCGTCATATTTTAGCGCGTCATGAACAAGGAGCAGTGCATGAAGCGGAAGGATTTGCAAAGTCAACAGGGAAACTTGGTGTAGCTATTGTTACCAGTGGTCCTGGAGCGACTAATGCCATTACCGGAATTGCTGATGCTATGAGTGATAGTGTCCCAATGTTGGTTTTTACTGGGCAGGTTGCAACTCCGGGTATTGGTAAAGATGCCTTTCAAGAAGCTGATATTATTGGTATTACAATGCCAATTACTAAATATAATTATCAGATTCGCGAAACAGCTGATATACCAAGAATTGTAACAGAGGCTGTTCATATTGCGACAACAGGACGTCCTGGGCCAGTTGTTATTGATTTACCTAAAGATGTTTCTGAGAAAAGAGTAAGTTCTTTTAATGAAACGACAATTAAAATTCCGGGTTATCAACCAACTATTGAGCCAAATAATTTACAAGTCAAGAAAATCTTGAGCCAATTAAAAAAGGCAAAGAAACCTTTGATTCTAGCAGGTGGCGGTGTCAATTATGCAGGAGCTTCTGCAGAACTTATTGCTTTTGCAGAACGTTATAAGATTCCTGTTGTCTCAACGCTTTTGAGTTTGGGAGTTATGCCAATTGAACATCCTTTATCATTAGGAATGGGAGGCATGCATGGTTCATATGCTTCCAATATGGCTTTGACGGAATGTGATTTTCTCATCAATTTTGGTTCGCGATTTGCGGATCGTTTGACAGGAAATCCTAAGACTTTTGCCCAAAAGGCTGTTGTGGCTCATGTTGATATAGATCCTGCTGAAATTGGCAAGGTTGTTAAGACGGCTATTCCAGTTGTGGGAGATGCCAAGAAAACCTTAAAACAGCTCTTAGAGTCTGATAAAGTATCCACAAGACACAGAGAATGGACGGATAAGGTCTTGCAAGATAAAGCTAAGGCTCCATTTAGTTATAAGTTTGACCAAGAAGTTATCAAACCGCAACATGCTATTGAAACAATTGGTAAATTAACAAAAGGTGATGCCATTATTATTACGGATGTTGGTCAGCATCAAATGTGGGCAGCTCAATTTTATCCTTATAAAAATGAGCGTCAGATTATCACATCAGGTGGTCTAGGAACAATGGGATTTGGTATTCCTGCAGCTGTGGGAGCCAAATTGGCTAATCCTGGTAAAGAGGTTGTTCTTTTTGTTGGTGATGGCGGTTTTCAAATGACTAATCAAGAATTGGCTATTTTAAATGGTTATGGCGTCCCAATTAAGCTTGTCTTAATTAATAATCATTCTTTAGGAATGGTTCGTCAGTGGCAGGAATCTTTTTATGATGAACGTCGCAGTGAGTCAACCTTTGATGATGAACCTAATTTCCAACTTTTAGCTGAATCTTATGGGATTAGCCATTATAAATTGGACAATCCTTTGACTTTAGAAAAAGATTTGGAAGTTATTTTGGAAAACAAGCCTATGTTGATAGAAGTTGATATTTCTAACCGTGAGCATGTTTATCCAATGGTACCATCAGGAAAGAGTAATGCGGAAATGTTGGGGGTGACTTTTAATGCGTAG","6.60","-2.87","61603","MEKIYLENPKSGSEILLDTLANLGVKTIFGYPGGAVLPLYDAIYKQDNIRHILARHEQGAVHEAEGFAKSTGKLGVAIVTSGPGATNAITGIADAMSDSVPMLVFTGQVATPGIGKDAFQEADIIGITMPITKYNYQIRETADIPRIVTEAVHIATTGRPGPVVIDLPKDVSEKRVSSFNETTIKIPGYQPTIEPNNLQVKKILSQLKKAKKPLILAGGGVNYAGASAELIAFAERYKIPVVSTLLSLGVMPIEHPLSLGMGGMHGSYASNMALTECDFLINFGSRFADRLTGNPKTFAQKAVVAHVDIDPAEIGKVVKTAIPVVGDAKKTLKQLLESDKVSTRHREWTDKVLQDKAKAPFSYKFDQEVIKPQHAIETIGKLTKGDAIIITDVGQHQMWAAQFYPYKNERQIITSGGLGTMGFGIPAAVGAKLANPGKEVVLFVGDGGFQMTNQELAILNGYGVPIKLVLINNHSLGMVRQWQESFYDERRSESTFDDEPNFQLLAESYGISHYKLDNPLTLEKDLEVILENKPMLIEVDISNREHVYPMVPSGKSNAEMLGVTFNA","220687","For the small subunit sequence, see SMu0210.For other 'ilv' genes see SMu1931 (ilvd); SMu0210 (ilvH); SMu0211 (ilvC); SMu0212 (ilvA) and SMu1099 (ilvE). Note tandem repeats at 219662,219697.","acetolactate synthase, large subunit (AHAS)","Cytoplasm, Membrane","Numerous matches in gapped BLAST to acetolactate synthase large subunits. Residues 1-567 are 69% similar to the enzyme from S.pneumoniae (gi15900362). Residues 1-565 are 65% similar to ILVB_LACLA (gi400050).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1192 (2e-58).","

InterPro
IPR000399
Family

TPP-binding enzymes
PIRSF001370	$\"[12-555]T$	Thiamine diphosphate-dependent enzyme, acetolactate synthase type
PS00187	$\"[429-448]T$	TPP_ENZYMES

InterPro
IPR011766
Domain

Thiamine pyrophosphate enzyme, C-terminal TPP-binding
PF02775	$\"[392-539]T$	TPP_enzyme_C

InterPro
IPR012000
Domain

Thiamine pyrophosphate enzyme, central region
PF00205	$\"[200-335]T$	TPP_enzyme_M

InterPro
IPR012001
Domain

Thiamine pyrophosphate enzyme, N-terminal TPP binding region
PF02776	$\"[10-180]T$	TPP_enzyme_N

InterPro
IPR012846
Family

Acetolactate synthase, large subunit, biosynthetic
PIRSF500108	$\"[10-567]T$	Acetolactate synthase, large subunit
TIGR00118	$\"[10-564]T$	acolac_lg: acetolactate synthase, large sub

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.970	$\"[11-198]T$ $\"[343-544]T$	no description
PTHR18968	$\"[240-560]T$	THIAMINE PYROPHOSPHATE ENZYMES
PTHR18968:SF13	$\"[240-560]T$	ACETOLACTATE SYNTHASE

","BeTs to 10 clades of COG0028COG name: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]Functional Class: E,HThe phylogenetic pattern of COG0028 is AMT-YqvCEBRH---------Number of proteins in this genome belonging to this COG is 2","***** IPB000399 (Thiamine pyrophosphate dependent enzyme) with a combined E-value of 7.5e-78. IPB000399A 20-43 IPB000399B 56-69 IPB000399C 80-103 IPB000399D 263-292 IPB000399E 419-458","Residues 186-335 are 30% similar to a (PROTEOME COMPLETE LARGE SUBUNIT) protein domain (PD304032) which is seen in Q9K659_BACHD.Residues 419-539 are 34% similar to a (SYNTHASE THIAMINE DEHYDROGENASE PYROPHOSPHATE PYRUVATE) protein domain (PD000580) which is seen in O28180_ARCFU.Residues 417-530 are 46% similar to a (SYNTHASE ACETOLACTATE FLAVOPROTEIN) protein domain (PD407122) which is seen in ILVI_BUCAP.Residues 11-167 are 60% similar to a (SYNTHASE THIAMINE PYROPHOSPHATE FLAVOPROTEIN LYASE) protein domain (PD000376) which is seen in Q9RU76_DEIRA.Residues 416-539 are 79% similar to a (SYNTHASE THIAMINE PYROPHOSPHATE FLAVOPROTEIN LYASE) protein domain (PD000397) which is seen in Q9CG84_LACLA.Residues 242-317 are 67% similar to a (SYNTHASE THIAMINE FLAVOPROTEIN PYROPHOSPHATE) protein domain (PD000679) which is seen in ILVB_LACLA.Residues 420-527 are 42% similar to a (PYROPHOSPHATE THIAMINE FLAVOPROTEIN) protein domain (PD401189) which is seen in Q9Z567_STRCO.Residues 322-415 are 44% similar to a (SYNTHASE ACETOLACTATE PYROPHOSPHATE) protein domain (PD262149) which is seen in ILVI_ECOLI.Residues 347-415 are 59% similar to a (SYNTHASE FLAVOPROTEIN THIAMINE) protein domain (PD212885) which is seen in ILVB_LACLA.Residues 127-240 are 27% similar to a (PROTEOME LARGE RELATED CHAIN) protein domain (PD397611) which is seen in Q9HKB0_THEAC.Residues 420-524 are 46% similar to a (DECARBOXYLASE PYRUVATE THIAMINE) protein domain (PD401689) which is seen in Q9RQ69_BBBBB.Residues 324-413 are 31% similar to a (FLAVOPROTEIN PYROPHOSPHATE THIAMINE LARGE) protein domain (PD212887) which is seen in Q9UZ10_PYRAB.Residues 108-200 are 62% similar to a (SYNTHASE THIAMINE PYROPHOSPHATE) protein domain (PD007687) which is seen in ILVB_BACSU.Residues 256-436 are 22% similar to a (PROTEOME COMPLETE DECARBOXYLASE) protein domain (PD315686) which is seen in Q9I280_PSEAE.Residues 117-417 are 22% similar to a (CARBOXYETHYLARGININE SYNTHASE) protein domain (PD358099) which is seen in Q9RIW1_STRCL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 14:56:20 2007","Fri Jan 4 11:37:30 2002","Tue Feb 20 12:53:16 2007","Mon Apr 1 13:33:44 2002","Fri Jan 4 11:37:30 2002","Fri Jan 4 11:37:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0209 is paralogously related (blast p-value < 1e-3) to SMu1322, a predicted acetolactate synthase.","Fri Jan 4 11:49:03 2002","Tue Feb 20 12:53:16 2007","pdb1POXA Chain A, Pyruvate Oxidase (E.C.1.2.3.3) Mutant With ... 212 9e-056pdb1POWA Chain A, Pyruvate Oxidase (E.C.1.2.3.3) (Wild Type) ... 212 1e-055pdb1BFD Benzoylformate Decarboxylase From Pseudomonas Putida 152 1e-037","SMU.231","","Residues 10 to 180 (E-value = 4.3e-100) place SMu0209 in the TPP_enzyme_N family which is described as Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (PF02776)Residues 199 to 352 (E-value = 1.3e-61) place SMu0209 in the TPP_enzyme_M family which is described as Thiamine pyrophosphate enzyme, central domain (PF00205)","Tue Feb 20 12:53:16 2007","24378741","","","Bar-Ilan A, Balan V, Tittmann K, Golbik R, Vyazmensky M, Hubner G, Barak Z, Chipman DM.Binding and activation of thiamin diphosphate in acetohydroxyacid synthase.Biochemistry. 2001 Oct 2;40(39):11946-54.PMID: 11570896Kisrieva IuS, Serebrennikov VM, Eneiskaia EV, Zagustina NA, Bezborodov AM.Isolation, purification and properties of acetolactate synthase from cultured Lactococcus lactisPrikl Biokhim Mikrobiol. 2001 Mar-Apr;37(2):227-31. Russian.PMID: 11357431","","Fri Jan 4 11:47:13 2002","1","","","SMU.231","" "SMu0210","220683","221165","483","ATGCGTAGAATGTTAACAGCCAAACTTCAAAATTCCACAGGAGTCCTGAATCGTTTTACAGGAGTTCTTTCTCGTCGGCAAGTTAATATTGAGTCTATCTCAGTAGGTCATACTGAAATTCCCAATATTTCAAGAATTACCATTATTATTGATGTTGACTCCTTGGAGGAAGTTGAACAGATTATGAAGCAGCTTAATCGTTTAATTGATGTTGTTCGTGTTCGAGATATTACAGATAAACCTCACTTGGAACGCGAAGTCATCTTGATTAAGGTTGCTGCCCCAACGAGTAAGCGTGCGGAGATTTTGGCGATTATTCAGCCTTTTCGTGCCAGTGTTATTGATGTCGCACCAAAGTCCATTACCATTCAAATGACTGGTGATGCAGATAAAATTGAAGCTCTTATTCGAGTCATTCAGCCTTACGGGGTGAAAAATATCGCTCGTACGGGAGCGACAGGCTTTACTAGAGATTTATCCTAA","10.70","5.48","17849","MRRMLTAKLQNSTGVLNRFTGVLSRRQVNIESISVGHTEIPNISRITIIIDVDSLEEVEQIMKQLNRLIDVVRVRDITDKPHLEREVILIKVAAPTSKRAEILAIIQPFRASVIDVAPKSITIQMTGDADKIEALIRVIQPYGVKNIARTGATGFTRDLS","221162","For the large subunit, see SMu0209.For other 'ilv' genes see SMu1931 (ilvd); SMu0209 (ilvB); SMu0211 (ilvC); SMu0212 (ilvA) and SMu1099 (ilvE)","acetolactate synthase, small subunit","Cytoplasm, Membrane","Several matches in gapped BLAST to acetolactate synthase small subunit sequences. Residues 1-158 are 82% similar to gi15902446 from S.pneumoniae and 80% similar to gi11611724 from S.thermophilus.SMu0210 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002912
Domain

Amino acid-binding ACT
PF01842	$\"[3-70]T$	ACT

InterPro
IPR004789
Family

Acetolactate synthase, small subunit
PD002844	$\"[1-77]T$	Acolac_synthsm
TIGR00119	$\"[1-159]T$	acolac_sm

noIPR
unintegrated

unintegrated
SSF55021	$\"[1-83]T$	SSF55021

","BeTs to 10 clades of COG0440COG name: Acetolactate synthase, small subunitFunctional Class: EThe phylogenetic pattern of COG0440 is AmT-yqvcEbrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 2-91 are 74% similar to a (SYNTHASE SMALL SUBUNIT ACETOLACTATE) protein domain (PD002844) which is seen in Q9F0I8_STRTR.Residues 92-157 are 87% similar to a (SYNTHASE SMALL SUBUNIT ACETOLACTATE) protein domain (PD002971) which is seen in Q9F0I8_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 14:56:42 2007","Fri Jan 4 11:50:12 2002","Tue Feb 20 13:03:49 2007","Mon Apr 1 13:43:03 2002","","Fri Jan 4 11:50:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0210 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 4 11:52:59 2002","","No significant hits to the NCBI PDB database.","SMU.232","","Residues 3 to 77 (E-value = 8e-16) place SMu0210 in the ACT family which is described as ACT domain (PF01842)","Fri Jan 4 11:50:12 2002","24378742","","","Bar-Ilan A, Balan V, Tittmann K, Golbik R, Vyazmensky M, Hubner G, Barak Z, Chipman DM. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase. Biochemistry. 2001 Oct 2;40(39):11946-54. PMID: 11570896 Kisrieva IuS, Serebrennikov VM, Eneiskaia EV, Zagustina NA, Bezborodov AM.Isolation,purification and properties of acetolactate synthase from cultured Lactococcus lactis Prikl Biokhim Mikrobiol. 2001 Mar-Apr;37(2):227-31. Russian. PMID: 11357431 ","","Fri Jan 4 11:54:20 2002","1","","","SMU.232","" "SMu0211","221232","222254","1023","ATGGCAGTAGAAATGTTATATGAAGCAGATGTAAAAGTAGCAGCACTTGATGGTAAGAAGATTGCTGTTATTGGTTATGGATCACAAGGACATGCTCATGCCCAAAACTTGAGAGATTCAGGACACGATGTTATCATCGGTGTGCGTCATGGGAAATCGTTTGACAAGGCTAAAGAAGATGGTTTTGATACCTATGAAGTGGGTGAAGCTACTAAATTGGCTGATATTATCATGGTTTTAGCACCGGATGAAATTCAAAAAGATATCTACAAAGATGAAATTGCTCCTAATTTAAGTGCTGGTAAGGCTCTTGGTTTTGCTCATGGTTTTAATATCCATTTCGGTTATATTAAGGCACCAGAAGATGTAGATGTTTTCATGGTTGCCCCTAAAGGACCGGGCCATCTTGTACGTCGTACTTACACAGAAGGATTTGGAGTACCTTCTTTATATGCTGTTTATCAAAATCCAACTGGTAATGCTGAAAATATTGCTTTAGATTGGGCTAAGGGTATTGGTTCTGCGCGTGTAGGTCTCCTTGTAACCACTTTCAAAGAAGAAACGGAAGAAGACCTTTTTGGTGAACAAGCGGTTCTTATGGGTGGTTTAACTCACCTTATTGAAGCAGGTTTTGAAGTGCTTACTGAAGCAGGGTATGCTCCACAATTGGCTTATTTTGAAGTGCTTCATGAAATGAAATTGATTGTAGACCTTATCTATGAAGGTGGTTTCAAGAAAATGCGTCAATCATGTTCAAATACCGCTGAATTTGGTGACTTTGTGACAGGCCCACGTGTTATCGGTCCAGAAGTAAAAGAAAACATGAAGGCTGCTCTTGCTGATATTCAATCAGGTAAATTTGCCCGTGAATTCGTGGAAGATCATGATGCTGGCTTCCCACGTTTGAAAGCTTTCCGTAAAGAAGCTGAAGGACTCGAAATCGAAAAAATTGGTGCAGAACTTCGTAAAGCAATGCCATTTGTTAATCAAAACGATGACGATGCTTTCAAAATTTATAACTAA","4.90","-15.60","37273","MAVEMLYEADVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGHDVIIGVRHGKSFDKAKEDGFDTYEVGEATKLADIIMVLAPDEIQKDIYKDEIAPNLSAGKALGFAHGFNIHFGYIKAPEDVDVFMVAPKGPGHLVRRTYTEGFGVPSLYAVYQNPTGNAENIALDWAKGIGSARVGLLVTTFKEETEEDLFGEQAVLMGGLTHLIEAGFEVLTEAGYAPQLAYFEVLHEMKLIVDLIYEGGFKKMRQSCSNTAEFGDFVTGPRVIGPEVKENMKAALADIQSGKFAREFVEDHDAGFPRLKAFRKEAEGLEIEKIGAELRKAMPFVNQNDDDAFKIYN","222251","For other 'ilv' genes see SMu1931 (ilvd); SMu0209 (ilvB); SMu0210 (ilvH); SMu0212 (ilvA) and SMu1099 (ilvE) ","ketol-acid reductoisomerase","Cytoplasm","Several matches in gapped BLAST to Ketol-acid reductoisomerase sequences, e.g. residues 1-340 are 81% similar to the enzyme from S.pneumoniae (gi|15902447) and 81% similar to the enzyme from S.thermophilus (gi|11611725).SMu0211 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000506
Domain

Acetohydroxy acid isomeroreductase C-terminal
PF01450	$\"[184-329]T$	IlvC

InterPro
IPR008927
Domain

6-phosphogluconate dehydrogenase, C-terminal-like
SSF48179	$\"[184-332]T$	6DGDH_C_like

InterPro
IPR013023
Family

Acetohydroxy acid isomeroreductase
TIGR00465	$\"[16-329]T$	ilvC

InterPro
IPR013116
Domain

Acetohydroxy acid isomeroreductase, catalytic
PF07991	$\"[15-178]T$	IlvN

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[3-182]T$	G3DSA:3.40.50.720
PIRSF000117	$\"[5-336]T$	IlvC_prok
PTHR21371	$\"[80-336]T$	PTHR21371
PTHR21371:SF1	$\"[80-336]T$	PTHR21371:SF1
SSF51735	$\"[3-181]T$	SSF51735

","BeTs to 11 clades of COG0059COG name: Ketol-acid reductoisomerase (isoleucine biosynthesis)Functional Class: EThe phylogenetic pattern of COG0059 is amt-yqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000506 (Acetohydroxy acid isomeroreductase) with a combined E-value of 1.1e-131. IPB000506A 19-43 IPB000506B 53-91 IPB000506C 120-156 IPB000506D 172-221 IPB000506E 230-258","Residues 7-328 are 81% similar to a (REDUCTOISOMERASE KETOL-ACID OXIDOREDUCTASE) protein domain (PD002380) which is seen in Q9F0I7_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:52:06 2002","Fri Jan 4 11:57:08 2002","Fri Jan 4 12:06:19 2002","Mon Apr 1 13:44:04 2002","Fri Jan 4 11:57:08 2002","Fri Jan 4 11:57:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0211 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome. See however the very weak similarity to SMu0290, a predicted glycerol-3-phosphate dehydrogenase.","Fri Jan 11 17:00:12 2002","Fri Jan 4 11:57:08 2002","pdb|1QMG|A Chain A, Acetohydroxyacid Isomeroreductase Complexed... 122 9e-029","SMU.233","","Residues 184 to 329 (E-value = 3.7e-76) place SMu0211 in the IlvC family which is described as Acetohydroxy acid isomeroreductase, catalytic domain (PF01450)","Fri Jan 4 11:57:08 2002","24378743","","","Garault P, Letort C, Juillard V, Monnet V.Branched-chain amino acid biosynthesis is essential for optimal growth of Streptococcus thermophilus in milk.Appl Environ Microbiol. 2000 Dec;66(12):5128-33.PMID: 11097879","","Fri Jan 4 12:08:54 2002","1","","","SMU.233","" "SMu0212","222495","223745","1251","ATGATTTCAGCTAAAGATGTGGTTGCTGCTAACAAAGTCTTAAAAGATGTTGTTGTTCAAACACCACTTGATTTTGATCGCTATTTGTCAGAAAAATATGGAGCGACAATTTATTTAAAACGTGAAAATATGCAAAAGGTGCGTTCTTTTAAAATTCGTGGCGCTTATTATGCTATTTCACAATTATCAGATGAAGAAAAGGCTAGAGGAGTTGTTTGTGCTTCTGCCGGAAATCATGCTCAAGGAGTTGCTTATACCTGTAATGAAATGAAAATTCCTGCAACTATTTTCATGCCTGTAACGACTCCTCATCAAAAGATTGGGCAAGTTCAATTTTTTGGAGGCTCCTTTGTAACTATCAAATTGGTAGGTGATACTTTTGATGCTTCTGCTCAGGCAGCCCAAGATTATACGAAAGCTGAAGGAATGACCTTTATCGATCCCTTTGATAATGACATGGTACAAGCGGGTCAAGGAACAATTGCTTATGAAATTTATGATCAGGCTCAAGAAGATGGTTTGAGCTTTGATGCTATTTTAGTACCTGTTGGTGGTGGCGGTCTTATTTCAGGTGTATCAGCCTATGTTAAAGATGTGGCTCCTGAAATTGAGGTTATTGGCGTTGAGGCAATGGGAGCGCGCAGCATGCGGGCAGCTTTTGATAAAGGACATCCTGTTAAATTAGAGCATATTGATAAATTTGCAGATGGCATAGCTGTTCAAAAGGTTGGGCGTTCTACCTATGATGTTGCTAGAAAATATGTGGATCGCTTGATTGGTGTAGATGAAGGTCTCATTTCTGAAACCTTGATTGATATGTATTCTAAACAAGGTATTATTGCAGAACCAGCAGGAGCAGCTTCTATTGCAGCTCTGGAAGAAATGAAAGATGATATTAAAGGCAAAACTATTGTCTGTATTATTTCTGGTGGAAATAATGACATTAACCGTATGCAAGAAATGGAAGAACGTGCACTTATTTATGATGGTGTGAAGCATTATTTTGTTGTGAATTTTCCACAACGCCCAGGAGCTCTGCGGGAATTTGTTAATGATATTTTAGGACCAAATGATGATATCACCCGTTTTGAATATATTAAACGTGCCAATAAAGGAACAGGTCCAGTCCTAATCGGCATTACTTTAGCGGATAAAAATGATTATCAGGATCTAATTGATCGTTTGGGTGCTTTTGACCCAGGTTATATCAATCTTCATGGCAATGAAAGTCTGTATAATATGCTCGTCTGA","4.90","-12.67","45494","MISAKDVVAANKVLKDVVVQTPLDFDRYLSEKYGATIYLKRENMQKVRSFKIRGAYYAISQLSDEEKARGVVCASAGNHAQGVAYTCNEMKIPATIFMPVTTPHQKIGQVQFFGGSFVTIKLVGDTFDASAQAAQDYTKAEGMTFIDPFDNDMVQAGQGTIAYEIYDQAQEDGLSFDAILVPVGGGGLISGVSAYVKDVAPEIEVIGVEAMGARSMRAAFDKGHPVKLEHIDKFADGIAVQKVGRSTYDVARKYVDRLIGVDEGLISETLIDMYSKQGIIAEPAGAASIAALEEMKDDIKGKTIVCIISGGNNDINRMQEMEERALIYDGVKHYFVVNFPQRPGALREFVNDILGPNDDITRFEYIKRANKGTGPVLIGITLADKNDYQDLIDRLGAFDPGYINLHGNESLYNMLV","223742","For other 'ilv' genes see SMu1931 (ilvd); SMu0209 (ilvB); SMu0210 (ilvH); SMu0211 (ilvC) and SMu1099 (ilvE)","threonine dehydratase","Cytoplasm","Matches in gapped BLAST to threonine dehydratase sequences. Residues 1-416 are 75% similar to the enzyme from S.pneumoniae (gi|15900367) and 63% similar to the enzyme from Lactococcus lactis (gi|15673209).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0334 (2e-08).","

InterPro
IPR000634
Binding_site

Serine/threonine dehydratase, pyridoxal-phosphate-binding site
PS00165	$\"[42-55]T$	DEHYDRATASE_SER_THR

InterPro
IPR001721
Domain

Threonine dehydratase, C-terminal
PF00585	$\"[323-415]T$	Thr_dehydrat_C

InterPro
IPR001926
Domain

Pyridoxal-5'-phosphate-dependent enzyme, beta subunit
PF00291	$\"[14-311]T$	PALP

InterPro
IPR011820
Family

Threonine dehydratase
TIGR02079	$\"[5-416]T$	THD1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1100	$\"[14-107]T$ $\"[113-341]T$	G3DSA:3.40.50.1100
PTHR10314	$\"[29-353]T$	PTHR10314
PTHR10314:SF17	$\"[29-353]T$	PTHR10314:SF17
SSF53686	$\"[5-361]T$	SSF53686

","BeTs to 7 clades of COG1171COG name: Threonine dehydrataseFunctional Class: EThe phylogenetic pattern of COG1171 is ----Y-vcEbrh--------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001721 (C-terminal domain of threonine dehydratase) with a combined E-value of 1.6e-119. IPB001721A 41-85 IPB001721B 146-168 IPB001721C 179-214 IPB001721D 219-272 IPB001721E 301-344***** IPB000634 (Serine/threonine dehydratase pyridoxal-phosphate attachment site) with a combined E-value of 2.2e-17. IPB000634A 40-54 IPB000634B 181-191 IPB000634C 278-297 IPB000634C 237-256***** IPB001926 (Pyridoxal-5'-phosphate-dependent enzymes, beta family) with a combined E-value of 4.3e-07. IPB001926A 71-98","Residues 132-213 are 52% similar to a (TRYPTOPHAN SYNTHASE LYASE PYRIDOXAL PHOSPHATE THREONINE) protein domain (PD002811) which is seen in Q9CG81_LACLA.Residues 315-416 are 73% similar to a (THREONINE DEHYDRATASE DEAMINASE LYASE) protein domain (PD013329) which is seen in Q9CG81_LACLA.Residues 215-348 are 26% similar to a (ALTERNATIVE CG8129 SPLICING) protein domain (PD225128) which is seen in Q9VHF0_DROME.Residues 215-314 are 55% similar to a (THREONINE DEHYDRATASE PROTEOME COMPLETE) protein domain (PD414066) which is seen in Q9CG81_LACLA.Residues 235-316 are 35% similar to a (DEHYDRATASE COMPLETE PROTEOME THREONINE) protein domain (PD390435) which is seen in Q9WYJ1_THEMA.Residues 225-314 are 36% similar to a (THREONINE DEHYDRATASE DEAMINASE LYASE) protein domain (PD409935) which is seen in P97116_LEUMC.Residues 10-118 are 29% similar to a (T5C23.70) protein domain (PD398809) which is seen in Q9T0D1_ARATH.Residues 21-151 are 63% similar to a (SYNTHASE LYASE CYSTEINE PYRIDOXAL PHOSPHATE BIOSYNTHESIS) protein domain (PD000323) which is seen in Q9XBI2_BACCE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:52:44 2002","Fri Jan 4 12:02:48 2002","Fri Jan 4 12:15:31 2002","Mon Apr 1 13:45:10 2002","Wed Oct 9 17:52:44 2002","Fri Jan 4 12:02:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0212 is paralogously related (blast p-value < 1e-3) to SMu0449, a predicted cysteine synthetase A, and SMu0488, a predicted tryptophan synthetase beta subunit.","Fri Jan 4 12:17:09 2002","Fri Jan 4 12:02:48 2002","pdb|1TDJ| Threonine Deaminase (Biosynthetic) From E. Coli 218 1e-057","SMU.234","","Residues 14 to 311 (E-value = 2.5e-92) place SMu0212 in the PALP family which is described as Pyridoxal-phosphate dependent enzyme (PF00291)Residues 323 to 415 (E-value = 1.2e-33) place SMu0212 in the Thr_dehydrat_C family which is described as C-terminal regulatory domain of Threonine dehydratase (PF00585)","Fri Jan 4 12:02:48 2002","24378744","","","Wessel PM, Graciet E, Douce R, Dumas R.Evidence for two distinct effector-binding sites in threonine deaminase by site-directed mutagenesis, kinetic, and bindingexperiments.Biochemistry. 2000 Dec 12;39(49):15136-43.PMID: 11106492Gallagher DT, Eisenstein E, Fisher KE, Zondlo J, Chinchilla D, Yu HD, Dill J, Winborne E, Ducote K, Xiao G, Gilliland GL.Polymorphous crystallization and diffraction of threonine deaminase from Escherichia coli.Acta Crystallogr D Biol Crystallogr. 1998 May 1;54 ( Pt 3):467-9.PMID: 9761930","","Fri Jan 4 12:15:31 2002","1","","","SMU.234","" "SMu0213","223800","224687","888","ATGGGAGTTTTTATTTTTTTGTGTTTCATACTGTTTTTGGTCATCCTTTTGATTGCCAGTGGACTTTATGTTGTTCGCCAACAAACAGTTGCTATTATTGAACGCTTTGGTAAATATCAATTGACTTCCGCTAGTGGGATTCATTTACGTTTACCTTTTGGAATTGATAAAATTGCTGCGCGTATCCAATTACGTCTGCTTCAATCGGAAATTATTGTCGAAACTAAGACAAAGGACAATGTTTTTGTGACGCTTAATGTTGCTACGCAATATAGGGTTAATGAGCAAAATGTTACTGACGCTTATTACAAACTCATGAGACCAGAAGCGCAAATACAATCTTATATTGAAGATGCTCTGCGTTCGTCTGTTCCTAAATTAACTTTAGATGAATTATTTGAGAAAAAAGATGAAATTGCTCTTGAAGTACAGCATCAAGTTGCGGAAGAAATGTCAACTTACGGTTATATCATTGTTAAAACCCTGATTACTAAGGTTGAACCTGATGCCGAAGTTAAACAATCAATGAATGAGATTAACGCTGCACAGCGTAAGCGCGTTGCTGCGCAAGAATTGGCAAATGCTGATAAAATTAAAATTGTCACTGCTGCAGAAGCTGAGGCTGAGAAAGATCGCCTTCATGGTGTTGGTATTGCACAACAACGTAAGGCGATTGTGGATGGTTTAGCTGAGTCTATCATGGAATTAAAGGGTACTAATGTATCATTGACAGAAGAGCAAATCATGTCTATTCTTTTGACTAATCAATATCTTGATTCTCTTAATACCTTTGCGCAACATGGCAATAGTTCCATTTTCTTACCTGCTAATCCTGAAGGAGCAGAAGACATTCGTACACAAGTCATGTCTGCCTTAAAAGCAAGATGA","5.60","-4.06","33018","MGVFIFLCFILFLVILLIASGLYVVRQQTVAIIERFGKYQLTSASGIHLRLPFGIDKIAARIQLRLLQSEIIVETKTKDNVFVTLNVATQYRVNEQNVTDAYYKLMRPEAQIQSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAEEMSTYGYIIVKTLITKVEPDAEVKQSMNEINAAQRKRVAAQELANADKIKIVTAAEAEAEKDRLHGVGIAQQRKAIVDGLAESIMELKGTNVSLTEEQIMSILLTNQYLDSLNTFAQHGNSSIFLPANPEGAEDIRTQVMSALKAR","224684","","conserved hypothetical protein, SPFH domain/band 7 family","Membrane, Cytoplasm","Matches in gapped BLAST to hypersensitive-induced response proteins and hypotheticals. Residues 19-295 are 89% similar to gi15675701 from S.pyogenes. Residues 20-294 are 86% similar to gi15904003 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0132 (1e-136).","

InterPro
IPR001107
Family

Band 7 protein
PF01145	$\"[21-197]T$	Band_7
SM00244	$\"[20-180]T$	PHB

noIPR
unintegrated

unintegrated
PTHR10264	$\"[1-295]T$	PTHR10264

","BeTs to 13 clades of COG0330COG name: Membrane protease subunits, stomatin/prohibitin homologsFunctional Class: OThe phylogenetic pattern of COG0330 is amTKYqVCEbrHuj--OL--XNumber of proteins in this genome belonging to this COG is 1","***** IPB001972 (Band 7 protein family/Stomatin) with a combined E-value of 8.9e-20. IPB001972A 22-38 IPB001972B 61-91 IPB001972C 101-150 IPB001972D 151-196","Residues 127-294 are 78% similar to a (PROTEOME COMPLETE TRANSMEMBRANE PROHIBITIN GNA1220) protein domain (PD001059) which is seen in Q9CHU0_LACLA.Residues 22-237 are 23% similar to a (PROTEOME COMPLETE) protein domain (PD107511) which is seen in P73049_SYNY3.Residues 25-126 are 32% similar to a (GNA1220 MEMBRANE PROTEOME COMPLETE) protein domain (PD413090) which is seen in Q9U160_LEIMA.Residues 20-154 are 30% similar to a (PROTEOME COMPLETE TRANSMEMBRANE PROTEASE) protein domain (PD300956) which is seen in Q9HUM2_PSEAE.Residues 25-125 are 74% similar to a (HYPERSENSITIVE-INDUCED RESPONSE T22N4.8) protein domain (PD207886) which is seen in Q9CHU0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 11:03:15 2006","Tue Sep 5 11:03:15 2006","Tue Sep 5 11:03:15 2006","Tue Sep 5 11:03:15 2006","Fri Jan 4 12:37:39 2002","Fri Jan 4 12:37:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0213 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 17:52:58 2002","","No significant hits to the NCBI PDB database.","SMU.235","","Residues 22 to 197 (E-value = 5.2e-43) place SMu0213 in the Band_7 family which is described as SPFH domain / Band 7 family (PF01145)","Fri Jan 4 12:37:39 2002","24378745","","","","","","1","","","SMU.235","232" "SMu0214","225451","224810","642","ATGGAAAACAACACGATTTTACACAACTATCAGGATTGGCTCGAGCATCACAAAATGCCTGCGGGGAAAAAGAAAACATTGGTCGCTGCTATTGAGCTCTTTTCTCAGCAAGGCTATAATGGGACTTCAACTGCCCAAATTGCAGAAAAGGCTGGAATTAGCCAAGCAACGATTTTTAAATATTTTAAAACCAAAAGTGACCTCCTATCAGAAATTATGCAGCCTATGATTCCTGAACTAAAAAGAGATTTTTTCCCAAAATTGCAAACTTATACTAAACTTGAAGAAGTTGTTCACTTTATTGTTCAGGATCGTTTTCAATTTTTGACTCAGAATGCTGACCTTATCAAAATTCTTATCCAAGAAGCTCTTGTCAATGTAAAATTACGAAAAACACTGTTAACCAATATTCAACTTACAATCTCAAAAGATTTCATGGCTTATTGGCAAACGTTAAAACAGATTAATCCTCAAATTAATCCTAATCTCAGTGGTATTGAGGTTATCAGAACCAATGTTGGCTTACTCTTTGCTTACTTCACACAGCGTTTTATTTTAAATATTCCAACACCATCAGAACAAAAGGATTTACTTCTAATTGAAAAACAAATTTTAACTTTGCTGATACTTGATACACATTAA","9.80","4.20","24678","MENNTILHNYQDWLEHHKMPAGKKKTLVAAIELFSQQGYNGTSTAQIAEKAGISQATIFKYFKTKSDLLSEIMQPMIPELKRDFFPKLQTYTKLEEVVHFIVQDRFQFLTQNADLIKILIQEALVNVKLRKTLLTNIQLTISKDFMAYWQTLKQINPQINPNLSGIEVIRTNVGLLFAYFTQRFILNIPTPSEQKDLLLIEKQILTLLILDTH","224813","","transcriptional regulator","Cytoplasm","Somewhat weak matches in gapped BLAST to transcriptional regulators of the TetR/AcrR family. Residues 6-130 are 37% similar to gi|16799997 from L.inocua. Residues 18-130 are 37% similar to gi|16802966 from L.momocytogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0258 (1e-37).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[26-39]T$ $\"[47-70]T$	HTHTETR
PF00440	$\"[26-72]T$	TetR_N
PS01081	$\"[38-69]T$	HTH_TETR_1
PS50977	$\"[20-80]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[10-98]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[4-72]T$	Homeodomain-rel

InterPro
IPR000412
Family

ABC-2
PS51012	$\"[175-404]T$	ABC_TM2

InterPro
IPR013525
Domain

ABC-2 type transporter
PF01061	$\"[207-371]T$	ABC2_membrane

","BeTs to 7 clades of COG0842COG name: Predicted integral membrane proteinFunctional Class: SThe phylogenetic pattern of COG0842 is A-TK--VcEBR-UJ-------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 273-373 are 36% similar to a (COMPLETE PROTEOME MEMBRANE TRANSPORT) protein domain (PD000633) which is seen in Q9CIV1_LACLA.Residues 216-272 are 52% similar to a (COMPLETE PROTEOME TRANSPORTER NOSY) protein domain (PD115342) which is seen in Q9CIV1_LACLA.Residues 235-379 are 30% similar to a (PROTEOME COMPLETE YFIN BH2100) protein domain (PD339698) which is seen in P94442_BACSU.Residues 2-130 are 23% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD399818) which is seen in Q9CIV1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:55:25 2002","Thu Sep 28 10:04:16 2006","Thu Sep 28 10:04:16 2006","Thu Apr 25 17:35:30 2002","","Fri Jan 4 12:48:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0215 is paralogously related (blast p-value < 1e-3) to SMu0018, a predicted glycoprotein, and SMu1409, an integral membrane protein.","Fri Jan 4 12:49:35 2002","","No significant hits to the NCBI PDB database.","SMU.237c","","No significant hits to the Pfam 11.0 database","Fri Jan 4 12:48:18 2002","24378747","","","","","","1","","","SMU.237c","" "SMu0216","227416","226697","720","ATGGAAAAATTACTAGATTTACAAGCTATTCGAAAAAATTTTGGTCATCAAGTTATCCTTAACAATATTAATTTCAGTTTGGATGCTGGTGAAATTATTGGCTTGATTGGTCCATCCGGTGCCGGAAAATCAACTATGATTAAAACCATGCTTGGAATGGAAAAGGCAGATGAAGGGGAAGCACTCGTTCTCAACCATCATATGCCAAATCGGCATATCTTAGGAGAAATCGGCTACATGGCACAATCCGATGCGCTTTACGAAACACTTTCTGGTTTGGAAAATATGGAATTTTTTGCTCAAATGAAGGGCTTAACTAAAATAGAGATTCCCCAAGCCATTGATCACGCTACCCAAGTTGTTGATTTATCCGAACATCTTAATAAGTCAGTTGCGGGTTATTCGGGAGGAATGAAGCGCCGTCTATCTTTAGCTATTGCCCTTCTGGGAAATCCCAGACTCCTTATTCTTGACGAACCAACTGTTGGTATTGATCCCGCATTGCGTCGCAAAGTCTGGAAAGAGCTACGCCAATTAAAAAAAGATGGTGTAGGTATTTTAGTTACAACACACGTTATGGATGAAGCTGAATTAACAGATAAGGTTGGCTTATTACTAGATGGAAAAATTATGGCTTTTGATAGTCCAAATAATTTAAAATCCATCTATGCTGTTGATACTATTGAAGATGTTTTCTTGAAGGCAGAAGGAGAATTATGA","5.40","-6.30","26229","MEKLLDLQAIRKNFGHQVILNNINFSLDAGEIIGLIGPSGAGKSTMIKTMLGMEKADEGEALVLNHHMPNRHILGEIGYMAQSDALYETLSGLENMEFFAQMKGLTKIEIPQAIDHATQVVDLSEHLNKSVAGYSGGMKRRLSLAIALLGNPRLLILDEPTVGIDPALRRKVWKELRQLKKDGVGILVTTHVMDEAELTDKVGLLLDGKIMAFDSPNNLKSIYAVDTIEDVFLKAEGEL","226700","For other components see SMu0215 (MSD1).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to ABC ATPbinding elements, e.g. residues 1-235 are 47% similar to gi|15672236 from L.lactis lactis. Residues 2-238 are 48% similar to gi|16799995 from L.inocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0260 (1e-88).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[134-176]T$	ABC_transporter
PF00005	$\"[30-208]T$	ABC_tran
PS00211	$\"[134-148]?$	ABC_TRANSPORTER_1
PS50893	$\"[5-232]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[29-217]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-219]T$	G3DSA:3.40.50.300
PTHR19222	$\"[5-234]T$	PTHR19222
PTHR19222:SF16	$\"[5-234]T$	PTHR19222:SF16
SSF52540	$\"[4-221]T$	SSF52540

","BeTs to 9 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.1e-27. IPB001140A 19-65 IPB001140B 131-169 IPB001140C 185-214***** IPB001324 (Phosphoribulokinase family) with a combined E-value of 6.5e-06. IPB001324A 29-50","Residues 4-211 are 22% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 68-173 are 34% similar to a (CG5944 NUCB1) protein domain (PD335045) which is seen in Q9VVK7_DROME.Residues 86-211 are 33% similar to a (LACF) protein domain (PD194047) which is seen in Q9RAV2_LACLA.Residues 78-176 are 29% similar to a (REPEAT AMV130 CG1494 CG8473) protein domain (PD328804) which is seen in Q9V912_DROME.Residues 15-210 are 28% similar to a (ATP-BINDING POLYSACCHARIDE TRANSPORT) protein domain (PD119675) which is seen in VEXC_SALTI.Residues 69-132 are 42% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD386448) which is seen in Q9CIV2_LACLA.Residues 20-68 are 51% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9ZK44_HELPJ.Residues 134-173 are 72% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9FLT5_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 23 13:36:21 2002","Wed Oct 23 13:36:21 2002","Wed Oct 23 13:36:21 2002","Thu Apr 25 17:34:58 2002","Fri Jan 4 12:57:23 2002","Fri Jan 4 12:57:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0216 is paralogously related (blast p-value < 1e-3) to SMu0596 (a MutF previously published in GenBank as gi|9802352), SMu0335, SMu0390, SMu1079, SMu1649, SMu1380, SMu0950, SMu1410, SMu0944, SMu1003, SMu0884, SMu0218, SMu0374, SMu1950, SMu0976, SMu0849, SMu0517, SMu1093, SMu1068, SMu0418, SMu0666, SMu0731, SMu1949, SMu1210, SMu1246, SMu1231, SMu0594, SMu0164, SMu1518, SMu1050, SMu1428, SMu0786, SMu1517, SMu0805, SMu0971, SMu1288, SMu0752, SMu0234, SMu1920, SMu1751, SMu1036, SMu0916, SMu0475, SMu1757, SMu1762, SMu1023, SMu0825, SMu1811, SMu0224, SMu0235, SMu0907, SMu1306, SMu1037, SMu0258, SMu0476, SMu1545, SMu1710, SMu1316, SMu1001, SMu1959, SMu1064, SMu0986, SMu0824, SMu1065, SMu0836, SMu0837, SMu0987, SMu1724, SMu0823, SMu0024, SMu0729, and SMu1686, all with ATP-binding capabiities.","Fri Jan 11 17:19:20 2002","Fri Jan 4 12:57:23 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 98 1e-021pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 87 2e-018","SMU.238c","","Residues 30 to 208 (E-value = 2.9e-55) place SMu0216 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Jan 4 12:57:23 2002","24378748","","Qi,F., Chen,P. and Caufield,P.W.Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis GenesAppl. Environ. Microbiol. 66 (8), 3221-3229 (2000)PUBMED 10919773","","Tue Oct 29 09:49:24 2002","","1","","","SMU.238c","890" "SMu0217","228202","227612","591","ATGATAACTTCACAAAAAAATGGATTGCAAAATTTACCTCTTTTCTTTTTTTCCTTTATAATATCAAAATGGATTTACGATCACTTTCTCATTTCTTATGCTCACTATATTGCTAATTACGGCATGAGTTTTGCCTTAAGGCTTAATATCATTATTACCTTTATCTTAACTTATTTTACTTTTGTTTTTCTAAAGTTTTGCCAAACACAGCAAATCCGAAACACAAGCATCATGATCTGTTACTTAATTTACATTTTGATGCTCATTTATGTTATCTTTCTAAAAGACATTGGTGCTCAAGGACTCTCGCTTAATCCTCTTTCCTTTATTACCGAAATAGCTAATGGCAGTAAATTTGTCCCCGTCATGAATCTACTTATGTTCATCCCTTTAGGTCTTCTGTTTCCTCTGTCAAAAACCAATTTATCTTTCTCTTTGTTGGGACTTTTATTAATAGAAAGTTGTCAATATATGTTTCATTTGGGAACACTTGATTTGGGTGATGTCACCTTAAACCTTCTTAGCATTGCTATTGGCAATATCTTGCATTTCCAGTTACAAAAATGGATAAAAAATTATAGAAGCAATTAA","9.70","5.80","22627","MITSQKNGLQNLPLFFFSFIISKWIYDHFLISYAHYIANYGMSFALRLNIIITFILTYFTFVFLKFCQTQQIRNTSIMICYLIYILMLIYVIFLKDIGAQGLSLNPLSFITEIANGSKFVPVMNLLMFIPLGLLFPLSKTNLSFSLLGLLLIESCQYMFHLGTLDLGDVTLNLLSIAIGNILHFQLQKWIKNYRSN","227615","","conserved hypothetical protein","Membrane, Cytoplasm","A few weak, fragmentary matches in gapped BLAST. Residues 93-188 are 32% similar to residues 91-188 of gi5701994 from S.thermophilus. Residues 122-190 are 33% similar to residues 64-146 of a predicted vanZ protein from S.pneumoniae (gi15899994).This sequence is similar to Str0155.SMu0217 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006976
Family

VanZ like protein
PF04892	$\"[80-189]T$	VanZ

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 93-188 are 32% similar to a (ORF14.9) protein domain (PD101358) which is seen in Q9RCJ9_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:56:44 2002","Tue Feb 20 13:23:08 2007","Tue Feb 20 13:23:46 2007","Fri Jan 4 13:01:46 2002","","Fri Jan 4 13:01:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0217 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 25 14:54:20 2002","","No significant hits to the NCBI PDB database.","SMU.239c","","No significant hits to the Pfam 11.0 database","Fri Jan 4 13:01:46 2002","24378749","","","","","","1","","","SMU.239c","" "SMu0218","229245","228505","741","ATGACTGACATTATTTTAGAAATTGACCATTTAAAAAAATCCTTCGGCAAAAATGAGGTTCTCAAAGACATTTCTCTAACAGTCAAAAAAGGGGAGGTCATCTCTATCATTGGATCTTCAGGATCTGGTAAATCAACATTTTTACGCTCTATTAACCTCCTTGAAAAACCTACTGGCGGTAAGATTCTCTATCGCGGACAAAATGTGCTTGAAAAAAATTATGACTTAACCAAATATCGTGAGAATTTAGGGATGGTGTTCCAATCTTTCAATCTCTTTAACAATCTTAATGTTCTTGAAAATGCCATAGTTGCCCAAACAACCGTCCTCAAGCGCAATCGTACAGAAGCAGAAAAAATCGCTAAAGACAACCTCAACAAAGTTGGTATGACTGAACAGTATTGGAAGGCAAAACCCAGTCAGCTTTCAGGCGGGCAAAAACAGCGGGTTGCTATCGCGCGTGCCCTGTCTGTAAATCCAGAGGCCATTCTCTTTGACGAACCGACATCTGCTCTTGATCCTGAAATGGTCGGTGAAGTTTTAAAAACAATCAAAGATCTAGCCAAATCAGGCCTGACTATGCTGGTTGTTACTCACGAAATGGACTTCGCCCGCGATGTATCAGACCGCGTTATCTTTATGGATCAAGGTGTCATTGCAGAAAGCGGAAAACCTGAACAAATCTTTGAAAATCCTCAAGAAGAACGCACTAAAGTTTTCTTACAGCGTTTTTTGAAGTAA","9.70","3.49","27608","MTDIILEIDHLKKSFGKNEVLKDISLTVKKGEVISIIGSSGSGKSTFLRSINLLEKPTGGKILYRGQNVLEKNYDLTKYRENLGMVFQSFNLFNNLNVLENAIVAQTTVLKRNRTEAEKIAKDNLNKVGMTEQYWKAKPSQLSGGQKQRVAIARALSVNPEAILFDEPTSALDPEMVGEVLKTIKDLAKSGLTMLVVTHEMDFARDVSDRVIFMDQGVIAESGKPEQIFENPQEERTKVFLQRFLK","228508","For other components see SMu0219 (MSD1) and (SBP1).","amino acid ABC transporter, ATP-binding protein","Membrane, Cytoplasm","Several hits in gapped BLAST to ABC ATP-binding proteins. Residues 1-246 are 76% similar to gi15900369 from S. pneumoniaeand 72% similar to gi15674454 from S.pyogenes.See similarity to SMu1762, previously published in GenBank.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0135 (1e-105).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[141-184]T$	ABC_transporter
PF00005	$\"[31-217]T$	ABC_tran
PS00211	$\"[142-156]T$	ABC_TRANSPORTER_1
PS50893	$\"[6-241]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-218]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-241]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-243]T$	PTHR19222
PTHR19222:SF33	$\"[6-243]T$	PTHR19222:SF33
SSF52540	$\"[5-242]T$	SSF52540

","BeTs to 7 clades of COG1126COG name: ABC-type polar amino acid transport system, ATPase componentFunctional Class: EThe phylogenetic pattern of COG1126 is a-----vcEB-Huj----inxNumber of proteins in this genome belonging to this COG is 7","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2e-37. IPB001140A 20-66 IPB001140B 139-177 IPB001140C 193-222***** IPB001324 (Phosphoribulokinase family) with a combined E-value of 3.5e-08. IPB001324A 30-51","Residues 185-225 are 75% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9WZ60_THEMA.Residues 185-226 are 66% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174) which is seen in Q9JVC3_NEIMA.Residues 125-223 are 30% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 140-184 are 48% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD334824) which is seen in Q9CP80_PASMU.Residues 185-242 are 58% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD255463) which is seen in OCCP_RHIME.Residues 186-225 are 62% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9KGD1_BACHD.Residues 125-239 are 26% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 21-71 are 45% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CEP0_LACLA.Residues 142-184 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in YECC_ECOLI.Residues 121-219 are 31% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD033004) which is seen in O59176_PYRHO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:57:23 2002","Tue Sep 5 11:11:17 2006","Tue Sep 5 11:11:17 2006","Thu Apr 25 17:34:29 2002","Mon Jan 7 11:46:46 2002","Mon Jan 7 11:46:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0218 is paralogously related (blast p-value < 1e-3) to SMu0517, SMu0731, SMu0849, SMu0418, SMu1380, SMu1762, SMu1079, SMu1036, SMu1920, SMu0971, SMu1288, SMu0916, SMu1949, SMu0786, SMu1003, SMu1246, SMu1231, SMu1068, SMu1037, SMu0884, SMu0235, SMu1950, SMu1210, SMu1517, SMu0234, SMu0594, SMu1001, SMu1757, SMu1751, SMu0976, SMu0805, SMu1023, SMu0596, SMu1518, SMu1710, SMu0216, SMu1093, SMu1428, SMu1065, SMu1649, SMu0390, SMu0258, SMu0335, SMu0950, SMu1410, SMu0907, SMu0374, SMu0944, SMu1064, SMu0824, SMu0475, SMu0224, SMu0666, SMu1724, SMu1316, SMu0836, SMu0164, SMu0986, SMu0752, SMu0476, SMu0825, SMu1811, SMu1306, SMu0987, SMu1959, SMu0837, SMu1545, SMu0823, SMu0024, SMu0729, SMu1050, SMu1202, and SMu1686, proteins with ATP-binding activity.","Mon Jan 7 11:50:18 2002","Tue Sep 5 11:11:17 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 208 7e-055pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 112 5e-026","SMU.241c","","Residues 31 to 217 (E-value = 7.4e-60) place SMu0218 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Jan 7 11:46:46 2002","24378750","","","","Tue Sep 5 11:11:17 2006","","1","","","SMU.241c","233" "SMu0219","230798","229245","1554","ATGAAAAAGACAATTTTAAGCTGTCTGGCTGCCCTTTTCATGCTGTTTATTGGTGTGACAAATGCTCAGGCAGACAACTACCTACGTGTTGGAATGGAAGCAGCTTATGCGCCTTTCAACTGGACCCAAGACAATAGCAGCAATGGGGCTGTACCTATTGAAGGAACAAAGCAATACGCAAACGGATACGATGTTCAAACAGCCAAAAAAATTGCTAAAACTCTGGGCAAAAAACCACTCATTGTTAAAACAAAATGGGAAGGACTTGTGCCAGCCCTAACATCCGGAAAAATTGATCTGATTATCGCTGGAATGAGTCCAACCAAAGAACGCAAAAAAGAAATTGCCTTTTCTAATAGCTACTATACTAGCGAGCCTGTTCTTGTTGTACGCAAAGACAGTAAGTATGCCAAAGCCAAAAATCTCAATGACTTCTCAGGCGCAAAGGTGACCTCCCAACAAGGTGTTTATCTTTATAATTTGATTAATCAGATTCCTAAAGTATCTCGGCAAACAGCTATGGGAGACTTCTCTCAGATGAGACAGGCCTTAGCTTCTAATGTTATTGATGCTTATGTCTCCGAACGTCCTGAAGCGCTGTCATCAACTAAAGCAAATTCAAACTTTAAAATGGTCTCTTTAAAAAACGGTTTTAAAGTAAGCAAATCCGATGTTACTATTGCTGTTGGTATGCGTAAAGGTGATCCACGAATAGAACAAGTCAACGCTGCCTTGGATCAATTTCCTCTAAAAGAGCAAATATCTTTAATGGATAAGATCATCCCAATGCAGCCTAGTCAAAATAACAGTGATCAAAAAGAAAGCAAATCTAACTTTTTCGACCAAGTCAGCAAAATTGTCAAAAACAATTGGAAAGCTCTTCTTCGTGGGACAGGTGTTACTTTACTCATTTCAATTATTGGTACAATTGCCGGTTTGATTATCGGCCTTCTTATTGGTGTTTATCGTACTGCTCCAAAAGCATCCAATCTTATCTTAGCTTGGTTACAAAAGATTTTTGGCTGGTTACTCACGGTTTATATTGAAGTCTTCCGAGGAACACCTATGATTGTACAAGCCATGGTTATATACTACGGAACGGCTCAAGCTTTTGGGGTCTCTCTTGATCGCACACTTGCTGCTATCTTTATTGTCTCTATCAATACAGGTGCTTATATGAGTGAAATCGTTCGTGGCGGCATCTTCGCCGTTGACAAAGGACAGTTTGAGGCTGCAACAGCACTTGGTTTCACCCACAGACAAACCATGAGAAAGATTGTTCTTCCGCAAGTTGTCCGCAACATTCTCCCTGCGACAGGTAACGAATTTGTCATCAACATCAAGGATACCTCTGTTTTGAATGTCATTTCTGTTGTAGAACTCTATTTTTCAGGTAATACTGTTGCAACCCAGACTTATCAATACTTCCAAACCTTCTTTATTATCGCTGTCATATACTTCATTTTAACCTTCACAGTAACGCGTATTCTTCGTTTGGTTGAAAGAAAAATGGACCAAGATAATTACACCAAAATTGAAGGAGAAACAAACTAA","10.50","21.21","57281","MKKTILSCLAALFMLFIGVTNAQADNYLRVGMEAAYAPFNWTQDNSSNGAVPIEGTKQYANGYDVQTAKKIAKTLGKKPLIVKTKWEGLVPALTSGKIDLIIAGMSPTKERKKEIAFSNSYYTSEPVLVVRKDSKYAKAKNLNDFSGAKVTSQQGVYLYNLINQIPKVSRQTAMGDFSQMRQALASNVIDAYVSERPEALSSTKANSNFKMVSLKNGFKVSKSDVTIAVGMRKGDPRIEQVNAALDQFPLKEQISLMDKIIPMQPSQNNSDQKESKSNFFDQVSKIVKNNWKALLRGTGVTLLISIIGTIAGLIIGLLIGVYRTAPKASNLILAWLQKIFGWLLTVYIEVFRGTPMIVQAMVIYYGTAQAFGVSLDRTLAAIFIVSINTGAYMSEIVRGGIFAVDKGQFEAATALGFTHRQTMRKIVLPQVVRNILPATGNEFVINIKDTSVLNVISVVELYFSGNTVATQTYQYFQTFFIIAVIYFILTFTVTRILRLVERKMDQDNYTKIEGETN","229248","For other components see SMu0218 (NBD1).","glutamine ABC transporter, solute binding protein","Membrane, Cytoplasm","Matches in gapped BLAST to amino-acid binding periplasmic protein fused to amino-acid permease (possible glutamine-binding periplasmic protein fused to glutamine permease). Residues 1-510 are 70% similar to this protein from S.pneumoniae (gi15900370) and 68% similar to from S.pyogenes (gi15674455).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0136 (0.0).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[298-506]T$	BPD_transp_1
PS50928	$\"[298-497]T$	ABC_TM1

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[28-246]T$	SBP_bac_3
SM00062	$\"[27-264]T$	PBPb

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[290-399]T$	HEQRo_perm_3TM

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[25-174]T$	G3DSA:3.40.190.10
PTHR18966	$\"[86-123]T$	Glut_Rec_Related
PTHR18966:SF35	$\"[86-123]T$	PTHR18966:SF35
SSF53850	$\"[1-248]T$	SSF53850

","BeTs to 8 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","***** IPB001638 (Bacterial extracellular solute-binding proteins, family 3) with a combined E-value of 4.1e-15. IPB001638B 90-121***** IPB000515 (Binding-protein-dependent transport systems inner membrane component) with a combined E-value of 7.3e-07. IPB000515 410-429","Residues 435-491 are 49% similar to a (TRANSPORT PERMEASE ABC TRANSPORTER) protein domain (PD006016) which is seen in Q9CEN9_LACLA.Residues 30-155 are 39% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT ABC TRANSPORTER) protein domain (PD245531) which is seen in Q9WZ62_THEMA.Residues 432-501 are 31% similar to a (AMINO-ACID MEMBRANE ABC TRANSPORT) protein domain (PD413409) which is seen in Y4TG_RHISN.Residues 433-486 are 42% similar to a (PERMEASE TRANSPORT TRANSPORTER ABC) protein domain (PD383635) which is seen in P73544_SYNY3.Residues 372-430 are 47% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in P73544_SYNY3.Residues 433-501 are 31% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE SYSTEM INNER PROTEOME) protein domain (PD415578) which is seen in ARTQ_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 17:58:10 2002","Tue Jul 11 09:01:22 2006","Tue Jul 11 09:01:22 2006","Thu Apr 25 17:33:43 2002","Mon Jan 7 11:52:07 2002","Mon Jan 7 11:52:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0219 is paralogously related (blast p-value < 1e-3) to SMu0732, SMu0516, SMu1382, SMu1080, SMu1111, SMu1383, SMu0417, SMu0739, SMu0848, SMu0741, SMu0847, SMu1381, SMu1078, SMu1765, SMu1761, SMu1112, SMu0846, SMu0416, SMu1426, and SMu0802, other predicted permeases.","Mon Jan 7 12:17:18 2002","Tue Jul 11 09:01:22 2006","pdb1WDNA Chain A, Glutamine-Binding Protein >gi1943541pdb1... 68 3e-012pdb1HSLA Chain A, Histidine-Binding Protein Complexed With L-... 63 9e-011","SMU.242c","","Residues 28 to 263 (E-value = 4.9e-32) place SMu0219 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)Residues 298 to 506 (E-value = 2e-28) place SMu0219 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Tue Jul 11 09:01:22 2006","24378751","","","","","","1","","","SMU.242c","22" "SMu0220","231574","232851","1278","TTGGAACTGCATGCTTATTGGAAACGTTCGGATTTTGCTGCTGCCACCGACAAGTCAAGCAAGAGATTATCAAAGTTTCAAGCTCTTGAAGCTAAAATTGCCAGACGTCAGAAATTTTATCCTCTTTTAGTCGGCTGGCTGTTTCCGATGGTCAGCGCCATCCTTATCCTTATTTCTATTGTTCTCTATGCTACTTGGAAAGTGGTATTAGGACAGAGAAAAACAGCAAGGCATATGCATTTATTCAGTCCGCCGGCTGACTTATCCCCTTTGATTCTTTCTCGTTATGTTTATGATTTAGAAATTCAAGAGTTATCTCCTTTGAAAACTAAGCGGAAGCGATATGATTTAGGTTTTAAACAGCTGATTCAAGCTAGCCTCTTAGATTTGATTGATCAAGGAAAACTAGTCATTGCAGATGATCATAAATCTTTTTTTGTTCCTGATTGGAATAGACTAGAAAGCTATGAAAAGAGATTTCTTATTTTTGTTTATGGCGATAATAAAAAGACCATGCCTATTGATGGTGCTTTTGATGATTATAAAATTGACAAAAGCATTTTCAAGGGCAGCAATGAGACAGAAATTCGTAGACGGGGCGGTGATATTCTCCATTTGTTTGAAAATCGTATGGAGAAGTTAGATAAGGCTGTTAAAAATAAAATAAGCTCTTTGAGTTTGAATGATATTCATCGTGAGAGAACGGGCGAAGAAAAGACTCAGCTTATCTTGGTTTATTTCTTTGCATCTACTGCCATGTTGTTTGCCTTTTTTGTAGGAGCTTTTGCTCTTATCAAGGGTTATTGGCTGGGGCTTGGGACCAATCTGTTATTGCTTATTGTAGCCAGTCTTTTTCTGATTTTCTATCGTCGAAAAGATGATTATTATAAGGTTTCAAGTCTTCTTACGCAAGAAGGCCTTGCTATCAAACAGGGTTGGGATTCTTTTGAGAATATGATTCGTGACATTAAGAGATTTGATGATGTCGAACTTGAAGGGGTTATTATCTGGAACCGTATTTTGGTCTATGCCACCCTTTACGGATATGCTGAACGTGTTCAAAATTATTTGAAAGTTAAAAATATTCATTTGCAGAACCCACAAATGAATACTTATCTTGAGATCAACCCGAGTTACTATGTGGGACAGTCAACCGCAGATTTATCAACCTATACCTCAACTGCTACGAGTGCTTCAAACTTTTCGGTATCGTCTGGCGGCTCAAGCGGCGGTGGTTTCTCCGGAGGCGGAGGCGGTGGAGGCGGCGGAGCCTTCTAA","10.20","12.70","48320","MELHAYWKRSDFAAATDKSSKRLSKFQALEAKIARRQKFYPLLVGWLFPMVSAILILISIVLYATWKVVLGQRKTARHMHLFSPPADLSPLILSRYVYDLEIQELSPLKTKRKRYDLGFKQLIQASLLDLIDQGKLVIADDHKSFFVPDWNRLESYEKRFLIFVYGDNKKTMPIDGAFDDYKIDKSIFKGSNETEIRRRGGDILHLFENRMEKLDKAVKNKISSLSLNDIHRERTGEEKTQLILVYFFASTAMLFAFFVGAFALIKGYWLGLGTNLLLLIVASLFLIFYRRKDDYYKVSSLLTQEGLAIKQGWDSFENMIRDIKRFDDVELEGVIIWNRILVYATLYGYAERVQNYLKVKNIHLQNPQMNTYLEINPSYYVGQSTADLSTYTSTATSASNFSVSSGGSSGGGFSGGGGGGGGGAF","232848","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins. Residues 1-391 are 31% similar to gi|15900371 from S.pneumoniae and residues 1-364 are 30% similar to gi|15674456 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0137 (1e-35).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[50-70]?$ $\"[242-262]?$ $\"[268-288]?$	transmembrane_regions

InterPro
IPR003824
Family

Bacitracin resistance protein BacA
PF02673	$\"[8-270]T$	BacA

","BeTs to 8 clades of COG1968COG name: Uncharacterized ACR, bacitracin resistance protein BacAFunctional Class: SThe phylogenetic pattern of COG1968 is --T--qvcebr-----o----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 87-263 are 59% similar to a (KINASE PROTEOME COMPLETE RESISTANCE) protein domain (PD008412) which is seen in Q9CDM7_LACLA.Residues 7-69 are 47% similar to a (KINASE PROTEOME COMPLETE RESISTANCE) protein domain (PD008077) which is seen in Q9RB37_CYTJO.Residues 5-66 are 59% similar to a (KINASE PROTEOME COMPLETE UNDECAPRENOL) protein domain (PD395640) which is seen in Q9CDM7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 22 11:37:14 2007","Tue Sep 5 11:26:17 2006","Thu Mar 22 11:37:14 2007","Mon Apr 8 14:59:29 2002","","Thu Mar 22 11:37:14 2007","yes","Fri Feb 20 15:41:32 MST 1998","SMu0221 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 12:06:22 2002","","No significant hits to the NCBI PDB database.","SMU.244","","Residues 8 to 270 (E-value = 7.8e-111) place SMu0221 in the BacA family which is described as Bacitracin resistance protein BacA (PF02673)","Mon Jan 7 12:03:22 2002","24378753","Thu Mar 22 11:37:14 2007","","Chalker AF, Ingraham KA, Lunsford RD, Bryant AP, Bryant J, Wallis NG, Broskey JP, Pearson SC, Holmes DJ.The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence.Microbiology. 2000 Jul;146 ( Pt 7):1547-53.PMID: 10878119Cain BD, Norton PJ, Eubanks W, Nick HS, Allen CM.Amplification of the bacA gene confers bacitracin resistance to Escherichia coli.J Bacteriol. 1993 Jun;175(12):3784-9.PMID: 8389741","","Mon Jan 7 12:09:41 2002","1","","","SMU.244","234" "SMu0222","233844","234566","723","ATGGAAATGAAACAAATCAGCGAAACAACATTAAAAATCACCATCAGTATGGAAGATTTAGAAGAAAGAGGCATGGAATTAAAAGATTTCTTGATTCCGCAGGAAAAGACGGAAGAATTTTTCTATACTGTTATGGATGAGCTGGACTTGCCTGAAAATTTCAAGGACAGTGGGATGTTAAGCTTTCGAGTAACACCAAGGAATGATCGCATTGATGTTTTTGTCACTAAGTCAGAAATCAATAAAAATCTTAATTTGGAGGATTTGTCTGATTTTGATGATATTTCAAAAATGTCTCCGGAGGATTTCTTTAATACCTTGGAGGAAACCATGCGTGAAAAAGGGGATGCTGCAGCTCTGGATAAATTGGCTGAAATTGAAAAAAGAGAAGAAGAGAAGACTCAGCAGGAAAAAGGTGAAACTAAGGAAAAAAGAGATTACGTTCACTTTGTGCTGGATTTTCCTAATATTCAGCAAGTCATAAATTTTGCTAAGACAGTTGACTATGATGTAGAGGCTTCAGAACTTTTTAAGGAGTCTGACGCTTATCACATGACTGTTCTGCTTAATCTCGAAGATAAACCCGACTATTATGCTGATCTTATGTTTGCAAGAATGTTGGAGCATGCTGGTAGAGGAACAAAGACACGTGCTTATCTATTAGAACATGGAGTTCAGCTCATTAAAGCAGATGCTCTGCAAGAATTACAAATGATTGGATAA","4.30","-23.99","28042","MEMKQISETTLKITISMEDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPENFKDSGMLSFRVTPRNDRIDVFVTKSEINKNLNLEDLSDFDDISKMSPEDFFNTLEETMREKGDAAALDKLAEIEKREEEKTQQEKGETKEKRDYVHFVLDFPNIQQVINFAKTVDYDVEASELFKESDAYHMTVLLNLEDKPDYYADLMFARMLEHAGRGTKTRAYLLEHGVQLIKADALQELQMIG","234563","","negative regulator of genetic competence","Cytoplasm","This sequence was previously published in GenBank as gi5360696, identified as a negative regulator of genetic competence. Also, residues 1-239 are 61% similar to gi15674458 from S.pyogenes and are 26% similar to gi15673777 from Lactococcus lactis lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0139 (3e-88).","

InterPro
IPR008681
Family

Negative regulator of genetic competence
PF05389	$\"[1-238]T$	MecA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-79 are 98% similar to a (PROTEOME COMPLETE REGULATOR NEGATIVE) protein domain (PD022512) which is seen in Q9XDW9_STRMU.Residues 146-239 are 98% similar to a (PROTEOME COMPLETE REGULATOR COMPETENCE) protein domain (PD314510) which is seen in Q9XDW9_STRMU.Residues 80-124 are identical to a (REGULATOR COMPETENCE GENETIC OF) protein domain (PD383639) which is seen in Q9XDW9_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 8 15:03:11 2002","Mon Jul 24 15:56:32 2006","Mon Jul 24 15:56:32 2006","Mon Jan 7 12:10:43 2002","","Mon Jan 7 12:10:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0222 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 12:16:06 2002","","No significant hits to the NCBI PDB database.","SMU.245","","Residues 1 to 238 (E-value = 2.7e-132) place SMu0222 in the MecA family which is described as Negative regulator of genetic competence (MecA) (PF05389)","Mon Jan 7 12:10:43 2002","24378754","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952","","Mon Apr 8 15:03:11 2002","","1","","","SMU.245","624" "SMu0223","234572","235732","1161","ATGATACCAATTACCTTAAAATTTGTTCTTGTACTAATTGCGACGCTTTTGACTTCACTTGTTTTGACTCCTTTAGTTAGATTTTTCGCTTTTAGGGTGGGGGCAGTTGATAATCCAAATGCGAGACGGATTAATAAGGTTCCTATGCCTAGTGCTGGCGGACTTGCCATTATTATTTCATTTGTGATTGCAACATTGGCTCTTATGCCCATGATTCTAAAAACGCAAATCGGAGGAAAATCCTATTTTGAATATATCTTACCAGTTGTTCTTGGTGCCTTAGTGATTGCCTTGACAGGTTTTATTGATGATGTTTATGAACTCTCACCTAAAATAAAATTCTTAGGTATTTTGCTTGGTGCTGTTATTATTTGGATTTTTACAGACTTTCGATTTGATAGTTTTAAGATTCCTTTTGGTGGTCCCATGCTCCACTTTAATCCTTTCTTGAGTTTCTTCTTAACGATTTTGTGGGTTGTTGCCATTACTAATGCTGTTAATTTGATTGATGGTTTGGATGGTTTGGTTAGTGGTGTTTCGATGATTAGTCTGACCACTATGGGATTGGTATCTTATTTTTTTCTCTATGATACCGATATTTTTTTAACACTTACTATTTTTGTTTTGATCTTTGCTATTGCTGGTTTCTTTCCTTATAATTACCATCCTGCTATTATCTATCTTGGTGATACTGGTGCTTTATTTATTGGTTTTATGATTTCGGTTTTATCTCTTCAAGGGTTAAAAAATGCAACGGCAGTTGCTGTTGTCACCCCTATCATTGTCTTAGGAGTTCCTATTGTTGATACGACGGTCGCCATTATCAGACGAACCTTATCAGGTCAGAAATTTTACGAAGCTGATAATATGCACTTACATCATAGATTGCTTGCTATGGGATTCACTCATCGCGGAGCTGTTTTAGTCGTCTATGGCATTGCTATGTTCTTCTCTTTGGTATCTCTGCTTTTAAATGTATCCAGTCGTCTGGGTGGGATCCTTCTTATGATTGGTGTTGCCTTTGCTTTGGAAATTTTTATTGAAGGTTTAGAGATTTGGGGACCTAAAAGAACACCACTCTTCAGACTATTGGCTTTTATTGGCAATAGTGATTACCGTCAAGAAGTAGTAGCTAAATATCGCCGTAAGAAGAAAAAGTAA","10.50","11.43","42589","MIPITLKFVLVLIATLLTSLVLTPLVRFFAFRVGAVDNPNARRINKVPMPSAGGLAIIISFVIATLALMPMILKTQIGGKSYFEYILPVVLGALVIALTGFIDDVYELSPKIKFLGILLGAVIIWIFTDFRFDSFKIPFGGPMLHFNPFLSFFLTILWVVAITNAVNLIDGLDGLVSGVSMISLTTMGLVSYFFLYDTDIFLTLTIFVLIFAIAGFFPYNYHPAIIYLGDTGALFIGFMISVLSLQGLKNATAVAVVTPIIVLGVPIVDTTVAIIRRTLSGQKFYEADNMHLHHRLLAMGFTHRGAVLVVYGIAMFFSLVSLLLNVSSRLGGILLMIGVAFALEIFIEGLEIWGPKRTPLFRLLAFIGNSDYRQEVVAKYRRKKKK","235729","","polysaccharide biosynthesis protein, glycosyl transferase family 4","Membrane, Cytoplasm, Extracellular","This sequence was previously published in GenBank as gi5360697, a predicted rgpG. Additionally, residues 1-384 are 68% similar to gi15674459 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0140 (1e-146).","

InterPro
IPR000715
Family

Glycosyl transferase, family 4
PTHR22926	$\"[27-382]T$	Glyco_trans_4
PF00953	$\"[86-253]T$	Glycos_transf_4

InterPro
IPR003524
Family

Phospho-N-acetylmuramoyl-pentapeptide transferase
PS01348	$\"[164-175]T$	MRAY_2

noIPR
unintegrated

unintegrated
PTHR22926:SF2	$\"[27-382]T$	PTHR22926:SF2

","BeTs to 15 clades of COG0472COG name: UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferaseFunctional Class: MThe phylogenetic pattern of COG0472 is -mTkyQVCEBRHUJ--olinXNumber of proteins in this genome belonging to this COG is 2","***** IPB003524 (Phospho-N-acetylmuramoyl-pentapeptide-transferase) with a combined E-value of 2.3e-15. IPB003524B 43-74 IPB003524D 159-176 IPB003524E 208-241","Residues 100-317 are 96% similar to a (TRANSFERASE TRANSMEMBRANE) protein domain (PD001416) which is seen in Q9XDW8_STRMU.Residues 85-133 are 53% similar to a (PROTEOME POLYSACHARIDE COMPLETE) protein domain (PD411150) which is seen in Q9CEP2_LACLA.Residues 329-377 are identical to a (PROTEOME POLYSACHARIDE COMPLETE) protein domain (PD262401) which is seen in Q9XDW8_STRMU.Residues 160-244 are 35% similar to a (TRANSFERASE) protein domain (PD006173) which is seen in RFE_MYCLE.Residues 30-357 are 25% similar to a (TRANSFERASE SCH35.52 2.-.-.- GLYCOSYL) protein domain (PD081334) which is seen in Y552_STRCO.Residues 10-67 are 77% similar to a (TRANSFERASE PROTEOME COMPLETE) protein domain (PD259181) which is seen in Q9XDW8_STRMU.Residues 89-340 are 24% similar to a (GLYCOSYLTRANSFERASE) protein domain (PD076069) which is seen in O69129_BURPS.Residues 260-316 are 46% similar to a (TRANSFERASE UNDECAPRENYL-PHOSPHATE) protein domain (PD020800) which is seen in RFE_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 25 15:05:24 2002","Tue Sep 5 11:34:50 2006","Tue Aug 3 15:14:46 2004","Thu Apr 25 15:04:09 2002","Mon Jan 7 12:18:00 2002","Mon Jan 7 12:18:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0223 is paralogously related (blast p-value < 1e-3) to SMu0413, a predicted undecaprenyl-phosphate-UDP-MurNAc-pentapeptide transferase.","Mon Jan 7 12:25:30 2002","","No significant hits to the NCBI PDB database.","SMU.246","","Residues 86 to 253 (E-value = 1.9e-39) place SMu0223 in the Glycos_transf_4 family which is described as Glycosyl transferase (PF00953)","Mon Jan 7 12:18:00 2002","24378755","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977Nomura R, Nakano K, Ooshima T.Molecular analysis of the genes involved in the biosynthesis of serotype specific polysaccharide in the novel serotype k strains of Streptococcus mutans.Oral Microbiol Immunol. 2005 Oct;20(5):303-9.PMID: 16101966","Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977Amer AO, Valvano MA.The N-terminal region of the Escherichia coli WecA (Rfe) protein, containing three predicted transmembrane helices, is required for function but not for membrane insertion.J Bacteriol. 2000 Jan;182(2):498-503.PMID: 10629198","Thu Apr 26 09:35:26 2007","Tue Aug 3 15:14:46 2004","1","","","SMU.246","235" "SMu0224","235806","236576","771","ATGTCTGTACTTGAAATAAAAGATCTTCATGTCTCTATTGAAGATAAAGAAATTTTAAAAGGTGTTAATCTGACCTTGAAAACAGGTGAAATTGCAGCCATTATGGGGCCTAACGGGACTGGGAAATCAACGCTTTCAGCAGCTATTATGGGAAATCCCATTTTTGAAGTGACACAAGGAGAAATTTTACTTGACGGTGAAAATATTTTGGAAATGGAAGTTGATGAGCGAGCTCGCTTAGGGCTTTTTCTTGCCATGCAATATCCGTCTGAAATTCCAGGAATTACTAATGCAGAATTCATCCGTGCGGCAATGAATGCTGGTAAGAAAGATGATGAGAAGATTTCTGTTCGTGATTTTATCATGAAACTGGATGAAAAAATGGAATTGCTGGGTATGAAAGAAGAAATGGCAGAGCGCTACCTTAACGAAGGCTTTTCTGGTGGTGAGAAAAAACGCAATGAAATCTTGCAATTACTGATGTTAGAGCCTAAATTTGCCCTTCTCGATGAAATTGACTCTGGCCTTGATATTGATGCCCTTAAGGTCGTTTCTAAGGGAGTTAATGCCATGCGTGGTGAAGGCTTTGGTGCTATGATTATTACCCACTACCAACGTCTGCTTAATTACATCACACCAGATATTGTTCATGTTATGATGGATGGTCGTGTTGTATTATCTGGCGGACCAGAGCTGGCAGCTCGACTCGAAAAAGAAGGTTATGCCCAAATCGCTGAAGAACTCGGTCTTGAATACAGCGAAGAAGTCTAA","4.40","-18.24","28267","MSVLEIKDLHVSIEDKEILKGVNLTLKTGEIAAIMGPNGTGKSTLSAAIMGNPIFEVTQGEILLDGENILEMEVDERARLGLFLAMQYPSEIPGITNAEFIRAAMNAGKKDDEKISVRDFIMKLDEKMELLGMKEEMAERYLNEGFSGGEKKRNEILQLLMLEPKFALLDEIDSGLDIDALKVVSKGVNAMRGEGFGAMIITHYQRLLNYITPDIVHVMMDGRVVLSGGPELAARLEKEGYAQIAEELGLEYSEEV","236573","","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Numerous matches in gapped BLAST to ABC transporter, ATP-binding proteins. Residues 1-256 are 84% similar to gi15902815 from S.pneumoniae. REsidues 1-255 are 82% similar to gi15674460 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0141 (1e-122).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[147-177]T$	ABC_transporter
PF00005	$\"[29-222]T$	ABC_tran
PS00211	$\"[146-160]?$	ABC_TRANSPORTER_1
PS50893	$\"[4-246]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-230]T$	AAA

InterPro
IPR010230
Family

FeS assembly ATPase SufC
PTHR19222:SF6	$\"[4-236]T$	SufC
TIGR01978	$\"[4-244]T$	sufC

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-231]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-236]T$	PTHR19222
SSF53795	$\"[16-244]T$	SSF53795

","BeTs to 11 clades of COG0396COG name: Iron-regulated ABC transporter ATPase subunit SufCFunctional Class: RThe phylogenetic pattern of COG0396 is amtK--Vcebr------lin-Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.7e-15. IPB001140A 18-64 IPB001140B 143-181 IPB001140C 199-228","Residues 75-145 are 49% similar to a (ATP-BINDING TRANSPORTER ATP-DEPENDENT) protein domain (PD006006) which is seen in Q9RSL7_DEIRA.Residues 73-114 are 57% similar to a (TRANSPORTER ATP-BINDING PROTEOME COMPLETE) protein domain (PD345181) which is seen in ABCX_ANTSP.Residues 189-241 are 79% similar to a (ATP-BINDING TRANSPORTER PROTEOME COMPLETE) protein domain (PD005991) which is seen in Q9CEP3_LACLA.Residues 146-188 are 62% similar to a (PROTEOME COMPLETE) protein domain (PD240758) which is seen in Q9V0M5_PYRAB.Residues 146-188 are 79% similar to a (ATP-BINDING TRANSPORTER PROTEOME SUFC) protein domain (PD195750) which is seen in Q9PDA4_XYLFA.Residues 74-145 are 65% similar to a (ATP-BINDING TRANSPORTER PROTEOME COMPLETE) protein domain (PD374973) which is seen in Q9CEP3_LACLA.Residues 19-72 are 77% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CEP3_LACLA.Residues 146-188 are 88% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in V296_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 14:07:03 2006","Tue Sep 5 14:07:03 2006","Tue Sep 5 14:07:03 2006","Fri Apr 26 09:27:54 2002","Mon Jan 7 12:27:49 2002","Mon Jan 7 12:27:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0224 is paralogously related (blast p-value < 1e-3) to SMu0731, SMu0218, SMu0517, SMu0235, SMu1380, SMu1757, SMu1949, SMu0884, SMu0825, SMu1079, SMu1036, SMu0216, SMu0849, SMu1003, SMu0786, SMu1518, SMu1037, SMu1649, SMu1410, SMu1762, SMu0986, SMu0418, SMu1023, SMu1950, SMu1246, SMu1231, SMu1065, SMu0476, SMu1920, SMu1710, SMu1517, SMu0374, SMu0837, SMu1064, SMu0390, SMu1316, SMu0944, SMu1306, SMu1210, SMu1001, SMu0836, SMu0594, SMu0258, SMu1751, SMu1545, SMu0907, SMu1811, SMu0596, SMu1093, SMu0824, SMu0475, SMu0164, SMu1959, SMu1068, SMu0234, SMu0971, SMu0335, SMu0916, SMu0823, SMu0976, SMu0805, SMu1288, SMu1724, SMu0950, SMu0024, SMu1428, SMu0729, SMu0666, SMu0987, and SMu0752, ABC-related ATP-binding proteins.","Mon Jan 7 12:31:22 2002","Tue Sep 5 14:07:03 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 68 2e-012","SMU.247","","Residues 29 to 222 (E-value = 1.1e-32) place SMu0224 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Jan 7 12:27:49 2002","24378756","","","","","","1","","","SMU.247","236" "SMu0225","236614","237876","1263","ATGACAAAAGAATCTATTTTAACATTTTCACAATCTAAGGCAGAGCCTGCTTGGCTACAAGAAAAACGCTTAGCGGCTTTTGATAAGATTGATGACTTAGAGCTTCCAAGAATTGAACGTGTTAAATTTCAACGTTGGAATTTGGGGGACGGTACGATTACTGAAAGTCCAATTTCGGCTAATGTTCCAGACTTCACTTCCTTTGGAGAGAATCCTAAGTTGGTTCAGCTTGGCACACAAACGGTTTTGGAAAGCTTGCCGGCAAAGCTTGTAGAACAAGGCGTCGTTTTTACAGATTTTCATTCAGCTCTAGAAGAAATTCCACAGGTCATTGAGAAGTATTTTGCCACTGCTCTTAAATTTGATGAGGATAAGTTGTCGGCCTATCATACAGCTTATTTTAACAGTGGATCCGTTCTTTATGTGCCTGACAATGTTGAAATTGACCTGCCTTTAGAAGGGATTTTTCTGCAGGACAGTACTAGCAATGTTCCGCTGAATAAGCATGTTTTAATCATTGCTGGACGCCATGCCAAGGTTAATTATTTGGAGCGTTTTGAGACGATTGGGGATAGCGATGTAAAGGCTACTGCCAATATTGCAGTTGAAGTTTTAGCACAGGCAGGCAGTCAAGTGAAATTTGCTGCTATTGATCGTTTGGGTAATAATATAACAACTTATATAAGCCGTCGCGGGCGTCTTGATAATGATGCCAGCATTGATTGGGCACTTGGTGTCATGAATGAAGGCAATGTTATTGCTGATTTTGACAGCGATCTTATCGGTAATGGCAGTCATGCTGAGTTGAAAGTTGTTGCGGCGTCAAGCGGTCGTCAAATTCAAGGAATTGACACTCGAGTGACCAACTACGGCAATAACTCTATCGGGCATATTCTCCAACACGGGGTTATCTTGGAACGTGGAACGCTAACTTTCAATGGTATTGGTCATATTATCAAGGGAGCTAAAGGAGCAGATGCTCAGCAGGAAAGTCGTGTCCTCATGCTTTCTGATAAAGCCAGAAGTGACGCTAATCCTATTCTTCTTATTGATGAAAATGAAGTCACAGCAGGGCATGCCGCGTCTATTGGACAAGTTGACCCAGAAGATATGTATTATCTAATGAGTCGCGGCATTGATAAAGAAACAGCAGAACGTTTGGTTATTCGTGGTTTCCTTGGAACAGTCATTACTGAAATTCCTGTTAAAGCTGTTCGTGACGAAATGATTGCTGTTTTGGATGAAAAATTGGATAAGAGATAA","4.80","-16.79","46124","MTKESILTFSQSKAEPAWLQEKRLAAFDKIDDLELPRIERVKFQRWNLGDGTITESPISANVPDFTSFGENPKLVQLGTQTVLESLPAKLVEQGVVFTDFHSALEEIPQVIEKYFATALKFDEDKLSAYHTAYFNSGSVLYVPDNVEIDLPLEGIFLQDSTSNVPLNKHVLIIAGRHAKVNYLERFETIGDSDVKATANIAVEVLAQAGSQVKFAAIDRLGNNITTYISRRGRLDNDASIDWALGVMNEGNVIADFDSDLIGNGSHAELKVVAASSGRQIQGIDTRVTNYGNNSIGHILQHGVILERGTLTFNGIGHIIKGAKGADAQQESRVLMLSDKARSDANPILLIDENEVTAGHAASIGQVDPEDMYYLMSRGIDKETAERLVIRGFLGTVITEIPVKAVRDEMIAVLDEKLDKR","237873","","ABC transporter permease","Cytoplasm, Extracellular","Several matches in gapped BLAST to conserved hypotheeeticcal proteins and potential ABC transporter components. Residues 1-419 are 73% similar to gi15902816 from S.pneumoniae. Residues 1-417 are 74% similar to gi15674461 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0142 (0.0).","

InterPro
IPR000825
Family

SufBD
PF01458	$\"[159-392]T$	UPF0051

InterPro
IPR011542
Family

FeS assembly protein SufD
TIGR01981	$\"[38-409]T$	sufD

noIPR
unintegrated

unintegrated
SSF101960	$\"[3-420]T$	SSF101960

","BeTs to 11 clades of COG0719COG name: Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufBFunctional Class: RThe phylogenetic pattern of COG0719 is amtK--VCEBR------LIN-Number of proteins in this genome belonging to this COG is 3","***** IPB000825 (Uncharacterized protein family UPF0051) with a combined E-value of 9.2e-25. IPB000825 343-393","Residues 131-401 are 65% similar to a (PROTEOME COMPLETE YCF24 CHLOROPLAST INTEIN ABC) protein domain (PD003219) which is seen in Q9CEP4_LACLA.Residues 4-128 are 48% similar to a (PROTEOME COMPLETE YURX YSFA) protein domain (PD353460) which is seen in Q9CEP4_LACLA.Residues 265-414 are 29% similar to a (PROTEOME COMPLETE MEMBRANE SUFD) protein domain (PD040896) which is seen in Q9X190_THEMA.Residues 308-407 are 31% similar to a (PROTEOME COMPLETE SLR0076 TC0058) protein domain (PD328727) which is seen in Q9LQK7_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:21:17 2002","Tue Jul 11 09:08:02 2006","Tue Jul 11 09:08:02 2006","Tue Oct 8 08:21:17 2002","Mon Jan 7 12:37:50 2002","Mon Jan 7 12:37:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0225 is paralogously related (blast p-value < 1e-3) to SMu0228, and SMu1180, both conserved hypothetical proteins.","Sun Jan 13 13:41:51 2002","","No significant hits to the NCBI PDB database.","SMU.248","","Residues 159 to 392 (E-value = 6.3e-50) place SMu0225 in the UPF0051 family which is described as Uncharacterized protein family (UPF0051) (PF01458)","Mon Jan 7 12:37:50 2002","24378757","","","","","","1","","","SMU.248","23" "SMu0226","237881","239110","1230","ATGACATTAGATACTCAAAAGATGAAACAGGATTTCCCCATTTTAAAACAAATTGTCAATGATGAACCTTTGGTGTATCTTGACAATGCAGCTACAACTCAAAAGCCAAAACAGGTTTTAGCTTGTTTGAATGATTACTATAGACAGGATAATGCTAATGTCCATCGTGGCGTCCATAGCTTGGCTGAAAGAGCAACAGCTGCTTACGAAGCTGCTCGTGAAAAAGTCCGTCGTTTTATCAATGCTGACTCAACTAAAGAAATTCTTTTTACGAGGGGGGCAACAACAGGTTTGAATTGGGCTGCTCGTTTTGCTGAGGAAGTGTTACAAGCAGATGACGAAGTTCTTATTTCTGTCATGGAACATCATTCTAATATCGTTCCATGGCAGGAAGCTTGCCGGAAAACGGGTGCTAAGTTAGTTTATGCTTATTTAAAAGATGGGCAGCTTGATTTAGAAGATCTTAAAAATAAAGTTTCTGCTAAAACAAGATTTATTAGTTTAACCCATATTTCTAATGTGCTAGGCTGTATCAATCCTATCAAGGAAATTGCACAGCTGGCTCATCAGCACAATGCCTACATGGTTGTTGATGGGGCACAATCGGCACCTCATATGACTATTGATGTTCAAGACTTAGACTGTGATTTCTTTGCTTTTTCAGGTCATAAGATGCTAGGACCTACTGGTATTGGTGTTCTTTATGGTAAAGAAGACATTCTTAAGCAAATGAGTCCTGTTGAATTTGGCGGTGAAATGATTGATTTTGTCTATGAACAAAAGACCACTTGGAAGGACTTGCCTTGGAAGTTTGAAGCAGGAACACCAAATATTGCAGGAGCCATTGCTCTTGGTGCAGCACTTGATTATTTAGCAGAATTGGGAATGGAACAGGTACAGGCTCATGAGCAAGAATTAGTGGCTTATGTTTTGCCTAAGTTGCAAGCTATTAAAGGGTTGACAGTCTATGGACCTGAGAATCCTGCAAAGCATACCGGGGTCATTTCCTTTAATCTGGAGGGTCTTCATCCTCATGATGTAGCAACAGCACTTGATTATGAAGGTGTTGCTGTTCGTGCAGGACATCATTGTGCACAGCCACTGATCAATTATTTAGGTCTTCATTCAGCAGCACGTGCAAGTTTTTATATTTATAATACAAAAGAAGACTGTGACAAATTAATAGAAGCGATTCTTAAAACAAAGGAGTTCTTTAATGGCACTCTCTAG","6.00","-9.41","45464","MTLDTQKMKQDFPILKQIVNDEPLVYLDNAATTQKPKQVLACLNDYYRQDNANVHRGVHSLAERATAAYEAAREKVRRFINADSTKEILFTRGATTGLNWAARFAEEVLQADDEVLISVMEHHSNIVPWQEACRKTGAKLVYAYLKDGQLDLEDLKNKVSAKTRFISLTHISNVLGCINPIKEIAQLAHQHNAYMVVDGAQSAPHMTIDVQDLDCDFFAFSGHKMLGPTGIGVLYGKEDILKQMSPVEFGGEMIDFVYEQKTTWKDLPWKFEAGTPNIAGAIALGAALDYLAELGMEQVQAHEQELVAYVLPKLQAIKGLTVYGPENPAKHTGVISFNLEGLHPHDVATALDYEGVAVRAGHHCAQPLINYLGLHSAARASFYIYNTKEDCDKLIEAILKTKEFFNGTL","239107","For other 'nif' genes see SMu0227 (nifU) and SMu0959 (nifS).","class-V aminotransferase, NifS protein homolog,","Cytoplasm","Numerous matches in gapped BLAST to aminotransferases and NifS-like proteins. Residues 3-409 are 69% similar to gi15674462 from S.pyogenes and 71% similar to gi15900752 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0143 (0.0).","

InterPro
IPR000192
Family

Aminotransferase, class V
PF00266	$\"[25-394]T$	Aminotran_5
PS00595	$\"[215-234]T$	AA_TRANSFER_CLASS_5

InterPro
IPR010970
Family

Cysteine desulphurases, SufS
TIGR01979	$\"[6-406]T$	sufS

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[38-294]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[3-403]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11601	$\"[24-405]T$	PTHR11601

","BeTs to 11 clades of COG0520COG name: Selenocysteine lyaseFunctional Class: EThe phylogenetic pattern of COG0520 is --t---vcEbrhujgpolin-Number of proteins in this genome belonging to this COG is 1","***** IPB000192 (Aminotransferase class-V) with a combined E-value of 2.3e-10. IPB000192A 25-33 IPB000192B 223-232","Residues 108-240 are 66% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9CEP5_LACLA.Residues 264-372 are 32% similar to a (AMINOTRANSFERASE) protein domain (PD313651) which is seen in Q9X805_STRCO.Residues 8-61 are 77% similar to a (LYASE PYRIDOXAL CYSTEINE PHOSPHATE) protein domain (PD007418) which is seen in Q9CEP5_LACLA.Residues 7-55 are 59% similar to a (PYRIDOXAL LYASE CYSTEINE DESULFURASE) protein domain (PD033780) which is seen in CSD_BACHD.Residues 334-400 are 77% similar to a (LYASE PYRIDOXAL CYSTEINE PHOSPHATE) protein domain (PD006196) which is seen in Q9CEP5_LACLA.Residues 268-394 are 30% similar to a (PROTEOME COMPLETE AMINOTRANSFERASE) protein domain (PD111848) which is seen in Q9KSS2_VIBCH.Residues 241-307 are 58% similar to a (LYASE PYRIDOXAL CYSTEINE PHOSPHATE) protein domain (PD186234) which is seen in Q9CEP5_LACLA.Residues 76-143 are 37% similar to a (PYRIDOXAL LYASE CYSTEINE DESULFURASE) protein domain (PD252975) which is seen in CSD_BORBU.Residues 270-341 are 31% similar to a (PROTEOME COMPLETE PA2958) protein domain (PD299959) which is seen in Q9HZP0_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 11 09:14:04 2006","Tue Oct 22 15:57:19 2002","Tue Jul 11 09:14:04 2006","Mon Apr 8 16:25:04 2002","Mon Jan 7 12:38:42 2002","Mon Jan 7 12:38:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0226 is paralogously related (blast p-value < 1e-3) to SMu0959,a predicted iron-sulfur cofactor synthesis protein, and to SMu0765, a predicted aminotransferase, and to SMu1074, a predicted O-acetylhomoserine sulfhydrylase.","Mon Jan 7 12:49:38 2002","Tue Jul 11 09:14:04 2006","pdb1C0NA Chain A, Csdb Protein, Nifs Homologue 358 7e-100pdb1ECXB Chain B, Nifs-Like Protein >gi7546479pdb1ECXA Ch... 92 9e-020pdb1EG5B Chain B, Nifs-Like Protein >gi7546280pdb1EG5A Ch... 89 1e-018","SMU.249","","Residues 33 to 394 (E-value = 5.6e-14) place SMu0226 in the Aminotran_5 family which is described as Aminotransferase class-V (PF00266)","Mon Jan 7 12:38:42 2002","24378758","","","Lacourciere GM, Mihara H, Kurihara T, Esaki N, Stadtman TC.Escherichia coli NifS-like proteins provide selenium in the pathway for the biosynthesis of selenophosphate.J Biol Chem. 2000 Aug 4;275(31):23769-73.PMID: 10829016Kiyasu T, Asakura A, Nagahashi Y, Hoshino T.Contribution of cysteine desulfurase (NifS protein) to the biotin synthase reaction of Escherichia coli.J Bacteriol. 2000 May;182(10):2879-85.PMID: 10781558Kaiser JT, Clausen T, Bourenkow GP, Bartunik HD, Steinbacher S, Huber R.Crystal structure of a NifS-like protein from Thermotoga maritima: implications for iron sulphur cluster assembly.J Mol Biol. 2000 Mar 24;297(2):451-64.PMID: 10715213 [","","Mon Jan 7 12:46:51 2002","1","","","SMU.249","24" "SMu0227","239097","239531","435","ATGGCACTCTCTAGATTAGATAGTCTTTATATGGCAGTTGTCGGGGATCATTCGAAAAATCCTCATCATCATGGTTTTTTAGAAGATGTGGAACAGGTTAATCTTAATAATCCCACTTGCGGTGATGTCATCAGTTTATCGGTTAAATTTGATGGTGATAAAATATCAGATATTGCCTTTGCAGGTGATGGCTGTACGATTTCAACCGCTTCATCCAGTATGATGACAGACGCTGTCATTGGCAAGACTAAAAAAGAAGCCCTTGAATTAGCAGATATCTTTTCTAAAATGGTTCAAGGGGAAAAAGATGATAGACAAAAGGAATTAGGAGATGCAGCATTTCTTGCGGGTGTTTCCAAATTTCCTCAACGTATCAAATGCTCAACCTTGGCATGGAATGCCCTTAAGAAAGCTATTGAGCGACAAGAAAATTAA","5.70","-3.19","15645","MALSRLDSLYMAVVGDHSKNPHHHGFLEDVEQVNLNNPTCGDVISLSVKFDGDKISDIAFAGDGCTISTASSSMMTDAVIGKTKKEALELADIFSKMVQGEKDDRQKELGDAAFLAGVSKFPQRIKCSTLAWNALKKAIERQEN","239528","For other 'nif' genes see SMu0226 (nifS) and SMu0959 (nifS).","nitrogen fixation-like protein, NifU","Cytoplasm, Periplasm","Several matches in gapped BLAST to NifU proteins. Residues 1-143 are 78% similar to gi15900753 from S.pneumoniae. Residues 1-144 are 78% similar to gi15674463 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0144 (1e-66).","

InterPro
IPR002871
Domain

Nitrogen-fixing NifU-like, N-terminal
PF01592	$\"[9-128]T$	NifU_N

InterPro
IPR011341
Family

SUF system FeS assembly protein
TIGR01994	$\"[6-140]T$	SUF_scaf_2

noIPR
unintegrated

unintegrated
PD032781	$\"[40-99]T$	PD032781
G3DSA:3.90.1010.10	$\"[9-139]T$	G3DSA:3.90.1010.10
PTHR10093	$\"[7-143]T$	PTHR10093
SSF82649	$\"[6-141]T$	SSF82649

","BeTs to 11 clades of COG0822COG name: NifU homologs involved in Fe-S cluster formationFunctional Class: CThe phylogenetic pattern of COG0822 is A---Yqv-ebrhujgp-linxNumber of proteins in this genome belonging to this COG is 1","***** IPB002871 (NifU-like N terminal domain) with a combined E-value of 1.5e-34. IPB002871A 10-25 IPB002871B 33-45 IPB002871C 51-83 IPB002871D 120-142","Residues 10-91 are 51% similar to a (NITROGEN FIXATION PROTEOME COMPLETE) protein domain (PD002743) which is seen in NIFU_BACSU.Residues 5-90 are 40% similar to a (PROTEOME COMPLETE NIFU ML0597) protein domain (PD031853) which is seen in O53156_MYCTU.Residues 40-99 are 38% similar to a (MG337 P02_ORF140 HOMOLOG) protein domain (PD032781) which is seen in Y337_MYCPN.Residues 9-141 are 27% similar to a (PROTEOME UU453 COMPLETE) protein domain (PD302277) which is seen in Q9PQ37_UREPA.Residues 37-90 are 74% similar to a (PROTEOME COMPLETE NIFU NITROGEN) protein domain (PD406274) which is seen in Q9CEP7_LACLA.Residues 93-140 are 79% similar to a (PROTEOME COMPLETE NIFU NITROGEN) protein domain (PD079264) which is seen in Q9CEP7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 13:04:55 2006","Mon Jan 7 12:51:51 2002","Wed Sep 27 13:04:55 2006","Mon Apr 8 16:26:09 2002","Mon Jan 7 12:51:51 2002","Mon Jan 7 12:51:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0227 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 12:54:31 2002","","No significant hits to the NCBI PDB database.","SMU.250","","Residues 9 to 128 (E-value = 3.3e-27) place SMu0227 in the NifU_N family which is described as NifU-like N terminal domain (PF01592)","Mon Jan 7 12:51:51 2002","24378759","","","Olson JW, Agar JN, Johnson MK, Maier RJ.Characterization of the NifU and NifS Fe-S cluster formation proteins essential for viability in Helicobacter pylori.Biochemistry. 2000 Dec 26;39(51):16213-9.PMID: 11123951 Agar JN, Yuvaniyama P, Jack RF, Cash VL, Smith AD, Dean DR, Johnson MK.Modular organization and identification of a mononuclear iron-binding site within the NifU protein.J Biol Inorg Chem. 2000 Apr;5(2):167-77.PMID: 10819462 Yuvaniyama P, Agar JN, Cash VL, Johnson MK, Dean DR.NifS-directed assembly of a transient [2Fe-2S] cluster within the NifU protein.Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):599-604.PMID: 10639125","","Mon Jan 7 12:58:30 2002","1","","","SMU.250","625" "SMu0228","239552","240967","1416","ATGCCAGAAAACGAAAGAGTAGAACCAAAGCCAATTGACATAGGAGACTATCAATTTGGCTTTCATGATGATGTTAAACCGATTGCATCAACTGGAAAAGGTCCGACGAAAGAGGCTGTTCGAGAAATATCCCGTATCAAAGGTGAACCAGAATGGATGTTGGACTTCCGTCTTAAATCGCTGGAGATATTTTATAAAATGCCTATGCAAGAATGGGGTCCTGACTTAACAGGTATTGATTTTGATGATATCATTTACTATCAAAAACCAACTGATAAACCAGCACGTTCATGGGAGGAAGTTCCAGAAAAAATCAAAGATACTTTTGAAAAGATTGGTATTCCTGAAGCGGAACGTGCTTATTTAGCTGGAGCTTCAGCTCAGTATGAATCAGAAGTTGTTTATCATAATATGAAAGAAGAATATGATAAACTTGGTATTGTTTTTACGGATACTGATTCAGCTCTTAAAGAATATCCTGAACTTTTCAAAAAATATTTTGCAAAATTGGTGCCGCCAACTGATAATAAATTAGCAGCTTTAAATTCAGCTTTTTGGTCAGGTGGAACCTTTATCTATGTGCCAAAAGGTGTTAAAGTAGATATTCCATTGCAGACTTACTTTCGTATCAATAATGAAGGAACGGGACAATTTGAACGGACCTTGATTATTGTTGATGAAGGTGCCAGCGTGCATTATGTGGAAGGCTGTACAGCACCGACTTATTCAACGGCCAGTCTGCATGCTGCTATTGTCGAAATTTTTGCCCTTGATGGTGCTTATATGCGTTATTCAACCATTCAAAACTGGTCAGATAATGTTTACAATTTGGTCACTAAGCGAGCCAAAGCTATGACAAACGCAACGGTGGAATGGATTGATGGTAATCTGGGAGCCCATACAACCATGAAATACCCATCTGTTTATCTTGACGGAGAAGGTGCGCGAGGCACCATGCTATCCATTGCTTTTGCCAATCGTGGTCAGCATCAGGATACAGGAGCTAAGATGATTCATAACGCTCCTCATACCAGTTCTTCTATTGTCTCCAAATCTATTGCTAAAGGTGGAGGAAAGGTAGATTATCGTGGGCAAGTATCTTTCAATAAGTCATCTCAAAAATCTGTTAGTCATATTGAATGTGATACCATCATTATGGATGATATTTCAGCATCTGATACCATTCCTTTTAATGAAATCCACAATTCACAAGTTGCTCTGGAACATGAAGCTAAGGTTTCAAAAATTTCAGAAGAACAGCTTTACTATCTCATGAGTCGTGGGTTAACGGAGTCAGAAGCTACTGAAATGATTGTCATGGGCTTTGTTGAGCCTTTTACCAAGGAACTTCCGATGGAGTATGCGATTGAACTCAATCGTTTGATTTCCTATGAGATGGAGGGTTCAGTTGGTTAA","4.90","-19.39","52864","MPENERVEPKPIDIGDYQFGFHDDVKPIASTGKGPTKEAVREISRIKGEPEWMLDFRLKSLEIFYKMPMQEWGPDLTGIDFDDIIYYQKPTDKPARSWEEVPEKIKDTFEKIGIPEAERAYLAGASAQYESEVVYHNMKEEYDKLGIVFTDTDSALKEYPELFKKYFAKLVPPTDNKLAALNSAFWSGGTFIYVPKGVKVDIPLQTYFRINNEGTGQFERTLIIVDEGASVHYVEGCTAPTYSTASLHAAIVEIFALDGAYMRYSTIQNWSDNVYNLVTKRAKAMTNATVEWIDGNLGAHTTMKYPSVYLDGEGARGTMLSIAFANRGQHQDTGAKMIHNAPHTSSSIVSKSIAKGGGKVDYRGQVSFNKSSQKSVSHIECDTIIMDDISASDTIPFNEIHNSQVALEHEAKVSKISEEQLYYLMSRGLTESEATEMIVMGFVEPFTKELPMEYAIELNRLISYEMEGSVG","240964","In S.pneumoniae, this protein is thought to contain an intein. ","ABC transporter permease","Cytoplasm, Extracellular","Numerous matches in gapped BLAST to conserved hypothetical proteins. Residues 5-471 are 89% similar to gi15902819 from S.pneumoniae. Residues 4-471 are 88% similar to gi15674464 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0145 (0.0).","

InterPro
IPR000825
Family

SufBD
PF01458	$\"[210-442]T$	UPF0051

InterPro
IPR010231
Family

FeS assembly protein SufB
TIGR01980	$\"[15-462]T$	sufB

noIPR
unintegrated

unintegrated
SSF101960	$\"[37-469]T$	SSF101960

","BeTs to 11 clades of COG0719COG name: Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufBFunctional Class: RThe phylogenetic pattern of COG0719 is amtK--VCEBR------LIN-Number of proteins in this genome belonging to this COG is 3","***** IPB000825 (Uncharacterized protein family UPF0051) with a combined E-value of 5.3e-30. IPB000825 393-443","Residues 183-467 are 81% similar to a (PROTEOME COMPLETE YCF24 CHLOROPLAST INTEIN ABC) protein domain (PD003219) which is seen in Q9CEP8_LACLA.Residues 223-443 are 24% similar to a (PROTEOME MJ0034 COMPLETE PH0883) protein domain (PD131349) which is seen in Q9X1D4_THEMA.Residues 128-182 are 60% similar to a (PROTEOME COMPLETE YURX YSFA) protein domain (PD353460) which is seen in Q9XAD1_STRCO.Residues 13-127 are 67% similar to a (PROTEOME COMPLETE YCF24 CHLOROPLAST) protein domain (PD005891) which is seen in Q9CEP8_LACLA.Residues 127-182 are 39% similar to a (YCF24 PROTEOME TRANSPORTER ABC) protein domain (PD228408) which is seen in YC24_ODOSI.Residues 183-450 are 25% similar to a (PROTEOME COMPLETE MEMBRANE SUFD) protein domain (PD040896) which is seen in Q9XAD2_STRCO.Residues 128-182 are 83% similar to a (PROTEOME COMPLETE INTEIN CLEAVAGE) protein domain (PD282952) which is seen in Q9CEP8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:22:09 2002","Tue Jul 11 09:26:57 2006","Tue Jul 11 09:26:57 2006","Tue Oct 8 08:22:09 2002","Mon Jan 7 13:21:43 2002","Mon Jan 7 13:21:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0228 is paralogously related (blast p-value < 1e-3) to SMu1180, and SMu0225, both conserved hypotheticals.","Mon Jan 7 13:23:16 2002","","No significant hits to the NCBI PDB database.","SMU.251","","Residues 210 to 442 (E-value = 2.8e-115) place SMu0228 in the UPF0051 family which is described as Uncharacterized protein family (UPF0051) (PF01458)","Mon Jan 7 13:21:43 2002","24378760","","","","","","1","","","SMU.251","25" "SMu0229","241259","242032","774","ATGAAAAGAAAGTTTATCATTCTTATAAGCCTCTTTGTTAGTCTTTTGATAGTGACAGCTTGTGATCTTCAAAATGTTAACCAGTCTATTAAAAAAGCGCAGCAAGCAGTGAACAAACGAGATGATAAGATGACTGTCAGCGATTTCTTTAAGAAAGTCAAAAGAGCCAATCGTTCTGTAGAAACGGTGCATTTTGATATGACGACTGACGTAGAATCACGTACTCGAAAACATCAGACCATGACAGCTGATATTGGGTATGATTCTTATACTGCTAGTATTAATAGAGCTAACATTATTATTGAAGAAACAATTAATGGTGTGGATAGTTATCAAGAGTTAGTTGGTAACCAAAACAGTTCTCAATCACGGACTTCTAAAGACGGCAATTGGACTAAGTCAAACGCTGCAGGCAGTTATCGGGTTCATCCTAGTTATTTTAATTTTTTAAAAGTACTCTATACCATGAAGGACGATTTAGTTCTTAAGCAAAGTGGCAATGTTTATAGGCTTGGCTTACGCAGTCAGAATGTAGATATCGTTTCTTTGTTTAAGGAAGAGTTGAATCTCTATTTGAGGGGGGTTAGTCAGTCAGAGTTAAAGAAAGGATTTGAAGTTACCTTTGACAAGAAAACTTTTCATTTAAAAACATTTAAGTTGAGCTTATCTTATGCTGGTAGCAGGGGACAGCTTGATATGATAGCCAAAGGTGAATTTTCGAGGTGGAATAAGCTTTCAGATTCTCAATTTTCTGTATCTGATTCGGATGCTTAG","10.30","10.91","29269","MKRKFIILISLFVSLLIVTACDLQNVNQSIKKAQQAVNKRDDKMTVSDFFKKVKRANRSVETVHFDMTTDVESRTRKHQTMTADIGYDSYTASINRANIIIEETINGVDSYQELVGNQNSSQSRTSKDGNWTKSNAAGSYRVHPSYFNFLKVLYTMKDDLVLKQSGNVYRLGLRSQNVDIVSLFKEELNLYLRGVSQSELKKGFEVTFDKKTFHLKTFKLSLSYAGSRGQLDMIAKGEFSRWNKLSDSQFSVSDSDA","242029","","hypothetical protein","Periplasm, Membrane, Extracellular","No significant hits in gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1361 (8e-04).","

noIPR
unintegrated

unintegrated
PS51257	$\"[1-21]T$	PROKAR_LIPOPROTEIN

InterPro
IPR001967
Family

Peptidase S11, D-alanyl-D-alanine carboxypeptidase A
PR00725	$\"[56-67]T$ $\"[112-129]T$ $\"[139-152]T$	DADACBPTASE1
PF00768	$\"[16-271]T$	Peptidase_S11

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[1-295]T$	PBP_transp_fold

InterPro
IPR012907
Domain

Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal
PF07943	$\"[295-395]T$	PBP5_C

noIPR
unintegrated

unintegrated
G3DSA:2.60.410.10	$\"[296-395]T$	G3DSA:2.60.410.10
G3DSA:3.40.710.10	$\"[17-295]T$	G3DSA:3.40.710.10
PTHR21581	$\"[8-413]T$	PTHR21581
SSF69189	$\"[295-397]T$	SSF69189

","BeTs to 7 clades of COG1686COG name: D-alanyl-D-alanine carboxypeptidaseFunctional Class: MThe phylogenetic pattern of COG1686 is --------EBRH----olinxNumber of proteins in this genome belonging to this COG is 1","***** PR00725 (D-Ala-D-Ala carboxypeptidase 1 (S11) family signature) with a combined E-value of 5e-17. PR00725A 56-67 PR00725B 112-129 PR00725C 139-152","Residues 300-414 are 40% similar to a (CARBOXYPEPTIDASE D-ALANYL-D-ALANINE) protein domain (PD102665) which is seen in P72518_STRPN.Residues 33-101 are 63% similar to a (CARBOXYPEPTIDASE PENICILLIN-BINDING D-ALANYL-D-ALANINE) protein domain (PD003893) which is seen in P72518_STRPN.Residues 105-268 are 53% similar to a (CARBOXYPEPTIDASE COMPLETE PROTEOME D-ALANYL-D-ALANINE) protein domain (PD003024) which is seen in Q54906_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 14:40:02 2006","Mon Jan 7 13:26:29 2002","Tue Sep 5 14:40:02 2006","Wed Apr 3 15:18:56 2002","Mon Jan 7 13:26:29 2002","Mon Jan 7 13:26:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0230 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 13:30:12 2002","","No significant hits to the NCBI PDB database.","SMU.253c","","Residues 16 to 271 (E-value = 4.9e-119) place SMu0230 in the Peptidase_S11 family which is described as D-alanyl-D-alanine carboxypeptidase (PF00768)","Mon Jan 7 13:26:29 2002","","","","Lee W, McDonough MA, Kotra L, Li ZH, Silvaggi NR, Takeda Y, Kelly JA, Mobashery S.A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis.Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1427-31.PMID: 11171967McArthur HA, Reynolds PE.Purification and properties of the D-alanyl-D-alanine carboxypeptidase of Bacillus coagulans NCIB 9365.Biochim Biophys Acta. 1980 Mar 14;612(1):107-18.PMID: 7362828","","Mon Jan 7 13:34:11 2002","1","","","SMU.253c","237" "SMu0231","243822","245471","1650","ATGATAGCAATAAAGAAAAGTCCATGGAAACGTGTTGGTTTAGGGCTGGTAACTGTTACTTCAGCAGCTATTTTAGCAGCCTGTGGAAACGGGAACAAGCAAACTTCAAAAGATGAGATTAATTGGTATACTCCAGTTGATATCAATTCTTTGGATATTTCAAAAAGTACAGATACTTATTCTGGTATCGCGATTGGAAATTCAGGAAGTAATCTGTTGCGTGTTGATGATAAAGGCAAACCAGCCCCTGACCTTGCTAAAAAAGTGGAAGTGTCAAAAGATGGCTTAACTTACACAGCAACATTGCGCAAGGGCATCAAATGGTCCGATGGTAGTGCCATTACAGCTAAGGATTTTGTTTACTCATGGCAGCGTATGGTTAATCCAAAGACAGCTTCAGAATATTCAGGTCTTGCTGTTGAGTCTCATGTAAAGAATGCCAAAGCCATTAATAGCGGTGACATTAAAGATCTTAATGAACTCGGAGTTAAGGCTGATGGCAATAAAGTTATCTTCACCTTAGAATCACCGACTCCTCAGATGAAATATCTGCTTGCTTTCACAAGCTTTATGCCACAAAAACAATCCTTTGTTGATAAAGTCGGTAGTAAATATGGGACCAATGCCAAGAGTCAAATTTATTCAGGACCTTACACTTTAAGTGGCTGGAATGGCACTAACGGCAGTTTTAAACTGAAAAAGAATAAATATTACTGGAATGCTGACAAGGTCAAAATTGATACCATTAATTTCCAAACGGTAAAAAAACCTGAGACAGCTGTTCAAATGTATAAGCGTGGTGAATTAGATACAGCTAATATTTCAAATACTCCAGCTCTTTTCAAAGCTAACAAGGGCAACAAAGATGTCGTTGATGTCTTTGAAGCAACAACTGCTTACATGCAGTATAACCAAACAGGCACTAACAAAGCTCTAGCTAATAAGAAAATTCGCCAAGCACTGAATTATGCAACTAATCGTAAGGCTTATGTAGAAACAGCGATACCAACAGGTTCACGCGCAGCAACTGGCGTAGCACCTTATAAATTGGCCAAAGTGGATGGTAAGGATCTTTCTAAGTATGTGGCACCGGGCTATACTTATAATGCCGCCAAAGCAAAACAACTCTTTAAGGAAGGTTTGCAAGAGATTGGCGAAACATCAGTGAAATTTACAGTGACTTCCGATGCTGATTCACCTGTAGCTAAATCTGGTCTTGACTATATTAAAGGAGCTTGGGAAAAGGCGCTTCCAGGTTTGACAATTGAAGAAAAATTCGTGCCGTTCAAACAGCGTATTCAAGATACACAAAATCAAAACTTTGAGATTGTCATGTCTCTTTGGGGCGGCGACTATCCAGAAGGTTCGACCTTCTACAGTAATTTCACGACAAGTTCACCTTATAATGGTGGAAAATTCGTAAATTCTACTTATGATCAGGCCTATGAAAAAGCAATTACAACGGATGCCTTAAATCCTACAAAGGCAGCTGAAGATTATAAAGCAGCAGAAAAAGCCTTATTTGATGAAGCAAATGTTAATCCAATTTACTTCCGCAGTACGAAGTCATTGCAAAACCCAAGTATCAAGGGTCTGATTCGCAGTTCTACAGGTTTGAATGTGGACTTCACCTATGCTTATAAGAAATAA","10.20","21.22","60221","MIAIKKSPWKRVGLGLVTVTSAAILAACGNGNKQTSKDEINWYTPVDINSLDISKSTDTYSGIAIGNSGSNLLRVDDKGKPAPDLAKKVEVSKDGLTYTATLRKGIKWSDGSAITAKDFVYSWQRMVNPKTASEYSGLAVESHVKNAKAINSGDIKDLNELGVKADGNKVIFTLESPTPQMKYLLAFTSFMPQKQSFVDKVGSKYGTNAKSQIYSGPYTLSGWNGTNGSFKLKKNKYYWNADKVKIDTINFQTVKKPETAVQMYKRGELDTANISNTPALFKANKGNKDVVDVFEATTAYMQYNQTGTNKALANKKIRQALNYATNRKAYVETAIPTGSRAATGVAPYKLAKVDGKDLSKYVAPGYTYNAAKAKQLFKEGLQEIGETSVKFTVTSDADSPVAKSGLDYIKGAWEKALPGLTIEEKFVPFKQRIQDTQNQNFEIVMSLWGGDYPEGSTFYSNFTTSSPYNGGKFVNSTYDQAYEKAITTDALNPTKAAEDYKAAEKALFDEANVNPIYFRSTKSLQNPSIKGLIRSSTGLNVDFTYAYKK","245468","For other components see SMu0235 (NBD1); SMu0234 (NBD2); SMu0233 (MSD1) and SMu0232 (MSD2).For other 'opp' genes see SMu0232 (oppB); SMu0233 (oppC); SMu0234 (oppD) and SMu0235 (oppF).SMu0231 has best BLAST match to hyaluronate synthase-associated protein from S.equi.","oligopeptide ABC transporter, OppA","Extracellular, Periplasm, Cellwall","Matches in gapped BLAST to hyaluronate-associated proteins and to oligopeptide transporters. Residues 10-517 are 62% similar to gi|4336671 from S.equi. Residues 9-549 are 50% similar to a predicted oligopeptide ABC transporter from L.lactis lactis (gi|15672326).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0148 (0.0).","

InterPro
IPR000914
Family

Bacterial extracellular solute-binding protein, family 5
PF00496	$\"[80-470]T$	SBP_bac_5

noIPR
unintegrated

unintegrated
G3DSA:3.10.105.10	$\"[297-518]T$	G3DSA:3.10.105.10
G3DSA:3.90.76.10	$\"[38-213]T$	G3DSA:3.90.76.10
PS51257	$\"[1-28]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[38-549]T$	SSF53850

","BeTs to 12 clades of COG0747COG name: Dipeptide/oligopeptide/nickel ABC-type transport systems, periplasmic componentsFunctional Class: EThe phylogenetic pattern of COG0747 is a-TK-qVCEBRHUJ--OlIN-Number of proteins in this genome belonging to this COG is 1","***** IPB000914 (Bacterial extracellular solute-binding protein, family 5) with a combined E-value of 3.4e-09. IPB000914A 83-90 IPB000914B 94-111","Residues 79-270 are 69% similar to a (PROTEOME COMPLETE PERIPLASMIC ABC) protein domain (PD000753) which is seen in Q9Z692_BBBBB.Residues 392-469 are 69% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT) protein domain (PD001762) which is seen in Q9Z692_BBBBB.Residues 10-78 are 63% similar to a (GLYCOSYLTRANSFERASE 2.4.1.- MEMBRANE) protein domain (PD351914) which is seen in Q9Z692_BBBBB.Residues 475-546 are 43% similar to a (PROTEOME COMPLETE BINDING OLIGOPEPTIDE) protein domain (PD406915) which is seen in Q9CIL2_LACLA.Residues 283-393 are 55% similar to a (PROTEOME COMPLETE BINDING) protein domain (PD191239) which is seen in Q06515_STREQ.Residues 275-466 are 23% similar to a (TRANSPORT LIPOPROTEIN PRECURSOR) protein domain (PD008768) which is seen in ALIB_STRPN.Residues 282-384 are 56% similar to a (PLASMID TRAC TRAB BINDING) protein domain (PD352696) which is seen in Q9CIL2_LACLA.Residues 284-385 are 32% similar to a (PROTEOME COMPLETE PERIPLASMIC TRANSPORT) protein domain (PD001217) which is seen in Q9LAT7_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:14:50 2002","Fri Apr 26 10:35:34 2002","Mon Jan 7 13:45:00 2002","Tue Apr 9 08:19:05 2002","Mon Jan 7 13:37:32 2002","Mon Jan 7 13:37:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0231 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 13:45:00 2002","Mon Jan 7 13:37:32 2002","pdb|1B05|A Chain A, Structure Of Oligo-Peptide Binding Protein ... 155 9e-039pdb|1JET|A Chain A, Oligo-Peptide Binding Protein (Oppa) Comple... 155 9e-039pdb|1DPE| Dipeptide-Binding Protein 94 4e-020","SMU.255","","Residues 18 to 548 (E-value = 2.7e-60) place SMu0231 in the SBP_bac_5 family which is described as Bacterial extracellular solute-binding proteins, family 5 (PF00496)","Mon Jan 7 13:37:32 2002","24378763","","","Lansing,M., Lellig,S., Mausolf,A., Martini,I., Crescenzi,F.,O'Regan,M. and Prehm,P.Hyaluronate synthase: cloning and sequencing of the gene fromStreptococcus spBiochem. J. 289 (Pt 1), 179-184 (1993)PubMed: 8424756Mausolf,A., Jungmann,J., Robenek,H. and Prehm,P.Shedding of hyaluronate synthase from streptococciBiochem. J. 267 (1), 191-196 (1990)PubMed: 2109602 Prehm,P. and Mausolf,A.Isolation of streptococcal hyaluronate synthaseBiochem. J. 235 (3), 887-889 (1986)PubMed: 3092808","","Wed Oct 9 18:14:50 2002","1","","","SMU.255","556" "SMu0232","245577","246491","915","ATGCTCAAATATATTCTTAAACGTTTGGGAATTCTTTTGCTGACTTTATTTATAGTTGTCACTATTACTTTCTTTCTCATGAAAGCGATGAAAGGAACTCCCTTTAACAATCCCAAATTAAGTCCGGATGCTATTGCTGCCCTGAACGTTCAATATGGTCTAGATAAACCTCAATGGCAACAATATTTGCTCTATTTGAAAAATGTCTTCACAGGTGACTTAGGAACTAGTTTTCAATATACCAATCAATCTGTGACGACACTTATTGTTCAAAGGCTAGGTATTTCTGCCCAACTTGGTTTACAAGCACTTGTCTTAGGTGTTGGAATGGGTTTGATTGTAGGTGCTCTTTCTGCGCGTCATCAAAACGATAAAATAGATGGTCTCCTAAGTGTCATTTCAACACTTGGTTATTCTGTTCCTTCTTTCATTTTGGCTGTTTTCTTGTTGAATACATTTGGCTATCGTCTGCAATTCTTACCTGTATCTGGTTGGGGCTCTTTTGCTCAAACCATTCTGCCGACCTTGGCGTTATCATTTAATCCATTTGCAGTAACAACTCGTTTTGTTAGAAGTGAGATGATTGAAGCTTTGAACTCTGATTACATTCAACTGGCGCGTGCTAAAGGTTTGACAGAACGTCAGGTTGCCAATCATCACGCCTATCGCAATTCAATGATTCCTGTTTTGACTTTAGTGGGTCCTATGGCTGCTAATCTTTTAACAGGTTCTGTATTGATTGAGAGAATTTTTTCGATTCCGGGTATCGGGGAGCAGTTTGTGAATTCCATCCCTTCTAATGATTATCCTGTTATCATGGGAACGACGATTGTTTATGCTGTTATGTTGATGAGTATGATCTTATTGACAGATATCGTTACCAGCATTGTTGATCCGCGCGTTCGTTTGCAGTAA","10.50","7.71","33439","MLKYILKRLGILLLTLFIVVTITFFLMKAMKGTPFNNPKLSPDAIAALNVQYGLDKPQWQQYLLYLKNVFTGDLGTSFQYTNQSVTTLIVQRLGISAQLGLQALVLGVGMGLIVGALSARHQNDKIDGLLSVISTLGYSVPSFILAVFLLNTFGYRLQFLPVSGWGSFAQTILPTLALSFNPFAVTTRFVRSEMIEALNSDYIQLARAKGLTERQVANHHAYRNSMIPVLTLVGPMAANLLTGSVLIERIFSIPGIGEQFVNSIPSNDYPVIMGTTIVYAVMLMSMILLTDIVTSIVDPRVRLQ","246488","For other components see SMu0235 (NBD1); SMu0234 (NBD2); SMu0233 (MSD1) and SMu0231 (SBP1).For other 'opp' genes see SMu0231 (oppA); SMu0233 (oppC); SMu0234 (oppD) and SMu0235 (oppF).","oligopeptide ABC transporter, permease","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to oligopeptide ABC transporter permeases,e.g. residues 1-303 are 58% similar to gi|15672327 from L.lactis lactis. Residues 1-304 are 43% similar to gi|15923976 from S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0149 (1e-102).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[93-303]T$	BPD_transp_1
PS50928	$\"[93-290]T$	ABC_TM1

","BeTs to 12 clades of COG0601COG name: Dipeptide/oligopeptide/nickel permeasesFunctional Class: E,PThe phylogenetic pattern of COG0601 is a-TK-qVCEBRHUJgpO-IN-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 133-303 are 29% similar to a (SYSTEM TRANSPORT PERMEASE) protein domain (PD113232) which is seen in O86691_STRCO.Residues 157-198 are 71% similar to a (TRANSPORT PERMEASE PROTEOME COMPLETE TRANSPORTER ABC) protein domain (PD077001) which is seen in Q9CIL1_LACLA.Residues 201-302 are 77% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD153522) which is seen in Q9CIL1_LACLA.Residues 27-95 are 59% similar to a (PERMEASE TRANSPORT PROTEOME COMPLETE) protein domain (PD001686) which is seen in Q9CIL1_LACLA.Residues 201-299 are 26% similar to a (NIKB) protein domain (PD257224) which is seen in Q9FAT0_VIBPA.Residues 201-289 are 39% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME) protein domain (PD151974) which is seen in Q9LCD2_OCHAN.Residues 118-200 are 45% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE) protein domain (PD345755) which is seen in Q9LAT6_LISMO.Residues 191-299 are 28% similar to a (TRANSPORT PEPTIDE SYSTEM INNER) protein domain (PD396175) which is seen in SAPB_HAEIN.Residues 184-302 are 26% similar to a (PROTEOME SYSTEM COMPLETE PEPTIDE) protein domain (PD396670) which is seen in Q9PM92_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:15:39 2002","Tue Oct 8 08:23:24 2002","Mon Jan 7 15:26:41 2002","Tue Apr 9 08:19:36 2002","","Mon Jan 7 15:23:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0232 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 15:26:41 2002","","No significant hits to the NCBI PDB database.","SMU.256","","Residues 93 to 303 (E-value = 2.1e-55) place SMu0232 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Mon Jan 7 15:23:21 2002","24378764","","","","","","1","","","SMU.256","883" "SMu0233","246502","247533","1032","ATGGCAGATAAAAATAGAGAGTTTGTGCTCATTGGGGCAGGAAGTACCAAAGCACAAGAAAAAATTGAAAAGCCGGCTCTATCTTTCTTACAAGATGCTTGGCGACAGTTAAAGAAAAATAAGTTAGCAGTTGTTTCACTTTGGTTTTTAACCTTATTAATCTCTTTTTCTTTGGTATCTCCTTTGTTTGTATCACAAAAAGATGCTAATAGTTTTGATTCGGACAAGGTATCAACTTATAGTAATTTGCCGCCTAATAGCGGTCTTGGTATTCCGGGTTGGAATGGTGTTTTTCAGATGCCAGGCTCTAGCAAGGCATCCAATGTCTATGAAGATCAAGCCGTTCCAAAAGGGAAAACATTCCTTTTGGGAACCGATAGTTTGGGACGCAGTCTAGGTAAGCGGATTATTGTTGGTGTTCGTATTTCGCTTTTAGTAGCAGTCGCTGCTACCTGCATTGACTTGCTTATTGGAGTTGTTTATGGTCTGACTTCGGGCTATGTTGGCGGTGCTGTTGATATCATTATGCAGCGGATTATTGAAATTATTTCTTCTGTTCCAAATCTAATTATCGTAACCATGTTAGGGCTTTTATTAGGGAATGGGATTATTGCAATTATCTTGTCCATTGCTTTAACGGGTTGGACTTCAATGGCAAGGCAGGTTCGAAACATGACCTTATCATATAAGGAAAGGGATTTTGTTTTAGCTGCCAGAACTTTAGGTGAAAGCAGTCCTAAAATTGCTTTTAAACATATTTTACCCAATATTTCTGGTGTTATTATTGTGCAAATTATGATGACGATTCCTTCTGCCATTATGTATGAAGCTATTCTTTCAGCTATCAATTTAGGAGTAAAACCACCAACGTCTTCTTTGGGTTCTCTTATTTCTGATGCTCAAGAAAATTTACAATATTACCCTTATCAAATCATCTTACCGGCTCTTGCTTTAGTCTTTATTTCTTTAGCATTTATTTTACTTGGAGATGGTTTACGTGATGCATTTGATCCAAAATCAGGACAAGACTAG","9.90","5.19","36907","MADKNREFVLIGAGSTKAQEKIEKPALSFLQDAWRQLKKNKLAVVSLWFLTLLISFSLVSPLFVSQKDANSFDSDKVSTYSNLPPNSGLGIPGWNGVFQMPGSSKASNVYEDQAVPKGKTFLLGTDSLGRSLGKRIIVGVRISLLVAVAATCIDLLIGVVYGLTSGYVGGAVDIIMQRIIEIISSVPNLIIVTMLGLLLGNGIIAIILSIALTGWTSMARQVRNMTLSYKERDFVLAARTLGESSPKIAFKHILPNISGVIIVQIMMTIPSAIMYEAILSAINLGVKPPTSSLGSLISDAQENLQYYPYQIILPALALVFISLAFILLGDGLRDAFDPKSGQD","247530","For other components see SMu0235 (NBD1); SMu0234 (NBD2); SMu0232 (MSD2) and SMu0231 (SBP1).For other 'opp' genes see SMu0231 (oppA); SMu0232 (oppB); SMu0234 (oppD) and SMu0235 (oppF).","oligopeptide ABC transporter, permease","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to transmembrane protein, permeases. Residues 1-343 are 54% similar to gi|15672328 from L.lactis lactis. Residues 20-339 are 42% similar to gi|16801362 from L.inocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0150 (1e-133).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[140-342]T$	BPD_transp_1
PS50928	$\"[140-329]T$	ABC_TM1

","BeTs to 11 clades of COG1173COG name: Dipeptide/oligopeptide/nickel ABC-type transport systems, permease componentsFunctional Class: E,PThe phylogenetic pattern of COG1173 is a-TK-qVCEBRHUj--o-IN-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 220-339 are 72% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD000562) which is seen in Q9CIL0_LACLA.Residues 144-194 are 50% similar to a (PERMEASE TRANSPORT PROTEOME COMPLETE) protein domain (PD411907) which is seen in Q9CIL0_LACLA.Residues 227-339 are 34% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME) protein domain (PD151974) which is seen in Q54909_STRPY.Residues 75-143 are 49% similar to a (PROTEOME OLIGOPEPTIDE COMPLETE TRASPORTER) protein domain (PD388342) which is seen in Q9CIL0_LACLA.Residues 20-73 are 55% similar to a (TRANSPORT PERMEASE OLIGOPEPTIDE) protein domain (PD374964) which is seen in Q9CIL0_LACLA.Residues 34-173 are 24% similar to a (PROTEOME COMPLETE PEPTIDE ABC) protein domain (PD274867) which is seen in Q9KUA5_VIBCH.Residues 116-334 are 22% similar to a (SYSTEM MEMBRANE INTEGRAL TRANSPORT) protein domain (PD294488) which is seen in Q9EWP8_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:19:04 2002","Tue Jan 8 15:34:40 2002","Mon Oct 28 13:19:04 2002","Tue Apr 9 08:32:48 2002","","Tue Jan 8 15:34:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0233 is paralogously related (blast p-value < 1e-3) to SMu0732, a predicted glutamine transport permease.","Tue Jan 8 15:35:41 2002","","No significant hits to the NCBI PDB database.","SMU.257","","Residues 140 to 342 (E-value = 1e-44) place SMu0233 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Tue Jan 8 15:34:40 2002","24378765","","","","","","1","","","SMU.257","750" "SMu0234","247543","248595","1053","ATGAGTAAGGAAAAAATTTTACAAGTCAATAACCTCCATGTCAATTTTCATACCTATGCAGGTGAAGTAAAAGCTATTCGCGATGTTAGTTTTTATTTAGAAAAAGGGGAAACGCTGGCTATTGTTGGCGAATCTGGTTCTGGAAAGTCGGTAACCACACGAACTTTAATGGGGTTGTCAGCAAAGAATGCTGAGATTTTCGGAGATATTGAGTTTAAGGGACACAATCTAAATGATTTGAAGGAAGAAGACTGGGTTCATATTCGCGGAAATGATATTTCCATGATTTTCCAAGATCCTATGACAAGTTTGGATCCAACCATGCGTATTGGCCTTCAAATTGCTGAACCTATTATCAAGCATGAAAAAGTAACTAAAAAAGAAGCTCTTAAGCGGGCTCTTGACATGATGGAAAAGGTTGGTATTCCCAATGCGCAAGAACACATCAACGATTATCCTCACCAGTGGTCAGGCGGTATGCGCCAGCGCGCTGTCATAGCTATTGCTTTGGCAACTAATCCTGAAATCCTTGTTGCAGATGAACCAACGACGGCTCTTGATGTTACCATTCAAGCACAAATTCTTCATTTAATGAAAGAAATCCAAAAGAATACTGACTCTTCCATTATCTTTATCACTCATGATTTGGGTGTCGTTGCAGGTATGGCAGACCGTGTTGCTGTTATGTATGCAGGCAAGATTGTGGAATATGGTACAGTAGATGAGGTTTTCTACAACCCACAGCATCCCTACACTTGGGGGCTTCTCAATTCGATGCCTACAACTAATACAGCTTCAGGCAGTTTGCATTCAATTCCCGGAACACCGCCTGACTTGTTGCAGCCCCCTCAAGGAGATGCTTTTGCTCCAAGAAATGAATTCGCTCTTGATATTGATCTTAAGGAGGAGCCGCCATTTTTTAAAGTTAGTGATTCACATTATGCTGCTACTTGGCTGTTAGATGATCGTGCTCCTAAGATTACTCCGCCGGAAAGAATTTTGCAGCGTTGGGAAAAATGGAAGAGCTTACAGGGAGAAAAGCATAATGACTGA","5.60","-9.84","39159","MSKEKILQVNNLHVNFHTYAGEVKAIRDVSFYLEKGETLAIVGESGSGKSVTTRTLMGLSAKNAEIFGDIEFKGHNLNDLKEEDWVHIRGNDISMIFQDPMTSLDPTMRIGLQIAEPIIKHEKVTKKEALKRALDMMEKVGIPNAQEHINDYPHQWSGGMRQRAVIAIALATNPEILVADEPTTALDVTIQAQILHLMKEIQKNTDSSIIFITHDLGVVAGMADRVAVMYAGKIVEYGTVDEVFYNPQHPYTWGLLNSMPTTNTASGSLHSIPGTPPDLLQPPQGDAFAPRNEFALDIDLKEEPPFFKVSDSHYAATWLLDDRAPKITPPERILQRWEKWKSLQGEKHND","248592","For other components see SMu0235 (NBD1); SMu0233 (MSD1); SMu0232 (MSD2) and SMu0231 (SBP1).For other 'opp' genes see SMu0231 (oppA); SMu0232 (oppB); SMu0233 (oppC) and SMu0235 (oppF).","oligopeptide ABC transporter, ATP-binding","Cytoplasm, Membrane","Matches in gapped BLAST to oligopeptide ABC transporter ATP-binding proteins. Residues 1-347 are 73% similar to gi14289333 from L.lactis lactis. Residues 4-343 are 67% similar to gi8131708 from L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0151 (1e-166).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[157-198]T$	ABC_transporter
PF00005	$\"[36-232]T$	ABC_tran
PS50893	$\"[7-256]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[35-233]T$	AAA

InterPro
IPR010066
Domain

Oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal
TIGR01727	$\"[233-319]T$	oligo_HPY

InterPro
IPR013563
Domain

Oligopeptide/dipeptide ABC transporter, C-terminal
PF08352	$\"[235-299]T$	oligo_HPY

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-265]T$	G3DSA:3.40.50.300
PTHR19222	$\"[7-323]T$	PTHR19222
PTHR19222:SF28	$\"[7-323]T$	PTHR19222:SF28
SSF52540	$\"[6-280]T$	SSF52540

","BeTs to 10 clades of COG0444COG name: ABC-type dipeptide/oligopeptide/nickel transport system, ATPase componentFunctional Class: E,PThe phylogenetic pattern of COG0444 is a-TKyqV-EB-Hujgpo-IN-Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.1e-23. IPB001140A 25-71 IPB001140B 153-191 IPB001140C 209-238","Residues 199-238 are 75% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9F5U3_BACTU.Residues 123-187 are 46% similar to a (ABC TRANSPORTER) protein domain (PD055062) which is seen in Q50241_METMA.Residues 200-252 are 43% similar to a (ATP-BINDING PROTEOME COMPLETE TRANSPORT) protein domain (PD402931) which is seen in Q9KUA7_VIBCH.Residues 6-69 are 39% similar to a (ATP-BINDING SAPD PEPTIDE TRANSPORT) protein domain (PD028306) which is seen in Q9KWT0_VIBAL.Residues 282-336 are 67% similar to a (TRANSPORT ATP-BINDING OLIGOPEPTIDE) protein domain (PD050924) which is seen in Q9LAT4_LISMO.Residues 93-145 are 51% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9ZMD5_HELPJ.Residues 201-256 are 48% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER) protein domain (PD019551) which is seen in O25032_HELPY.Residues 93-142 are 44% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD261527) which is seen in Q9ZMD4_HELPJ.Residues 201-279 are 35% similar to a (SAPD TRANSPORT ATP-BINDING PEPTIDE) protein domain (PD407079) which is seen in O86190_ERWCH.Residues 240-280 are 73% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD029971) which is seen in Q9CIK9_LACLA.Residues 82-127 are 76% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD332659) which is seen in Q9CIK9_LACLA.Residues 240-278 are 65% similar to a (ATP-BINDING TRANSPORT PROTEOME) protein domain (PD253984) which is seen in OPPD_BACSU.Residues 98-252 are 29% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 26-80 are 78% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CIK9_LACLA.Residues 209-278 are 47% similar to a (ATP-BINDING TRANSPORT PEPTIDE PROTEOME) protein domain (PD259958) which is seen in Q9HLF8_THEAC.Residues 157-198 are 88% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CIK9_LACLA.Residues 88-153 are 53% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE ABC OLIGOPEPTIDE) protein domain (PD000720) which is seen in Q9WXR4_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 14:57:37 2006","Tue Jan 8 15:39:18 2002","Tue Sep 5 14:57:37 2006","Tue Apr 9 08:33:51 2002","Tue Jan 8 15:39:18 2002","Tue Jan 8 15:39:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0234 is paralogously related (blast p-value < 1e-3) to SMu0235, SMu1762, SMu0517, SMu0731, SMu1288, SMu1068, SMu0971, SMu0218, SMu0418, SMu1380, SMu1003, SMu1751, SMu1246, SMu1231, SMu0884, SMu1950, SMu1036, SMu0916, SMu0786, SMu0849, SMu1037, SMu1079, SMu1949, SMu1920, SMu1210, SMu0805, SMu0594, SMu0216, SMu1428, SMu1517, SMu1757, SMu0390, SMu0907, SMu0976, SMu1518, SMu1001, SMu0950, SMu0475, SMu1316, SMu0258, SMu1064, SMu1023, SMu1710, SMu0335, SMu1410, SMu0374, SMu0476, SMu1649, SMu0837, SMu0944, SMu0825, SMu0824, SMu1811, SMu0596, SMu0987, SMu0823, SMu0836, SMu1065, SMu0164, SMu1050, SMu0986, SMu1724, SMu0729, SMu0752, SMu0224, SMu0666, SMu1093, SMu1959, SMu0024, SMu1545, and SMu1306, all ATP-binding proteins.","Tue Apr 9 08:33:51 2002","Tue Sep 5 14:57:37 2006","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 123 2e-029pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 121 2e-028","SMU.258","","Residues 36 to 232 (E-value = 9.6e-59) place SMu0234 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jan 8 15:39:18 2002","24378766","","","","Tue Sep 5 14:57:37 2006","","1","","","SMU.258","238" "SMu0235","248588","249514","927","ATGACTGAAAATCGTAAAAAACTAGTTGAAGTCAAAAATGTTTCTTTGACATTCAATAAAGGAAAAGCCAACCAAGTAAAAGCAATAGATAATGTCAGCTTTAATATCTATGAAGGAGAAGTTTTTGGACTTGTTGGGGAATCTGGCTCAGGTAAGACGACAATTGGCCGTGCTATTTTAAAACTTTACAATATTGATAAAGGAGAAATTGATTTTGAAGGCGAAACGATTTCAAAATTAAAGGGAAAATCATTGTTTAATTTTCGTAAGAAAGCGCAAATGATTTTCCAAGATCCTCAAGCCAGCTTGAATAGTCGCATGAAAGTTAGGGATATTATTGCTGAAGGACTTGATGTTCATAAATTGGTTAAAAATAAGGCAGACCGTGACGCAAAAGTTCAGGATTTACTGGATCTGGTTGGGTTAAATAAGGATCATTTAACACGTTATCCGCATGAATTTTCAGGCGGTCAGCGTCAACGGATTGGGATTGCTCGTGCTTTGGCGGTTGAGCCTAAATTCATTATTGCTGATGAGCCCATCTCTGCTTTGGATGTCTCTATCCAAGCTCAGGTTGTTAATCTCATGCAAAAACTGCAGCATGAACAGGGACTAACGTACCTGTTCATTGCTCATGATTTATCAATGGTTAAGTATATTTCGGATCGCATTGGTGTGATGCATTGGGGAAAAATTGTGGAAATTGGGACATCTGATGAGGTTTACCATCACCCCATTCATCCTTATACTCAAAGTCTCTTATCAGCTGTTCCTGAACCCGATCCAGTTTTAGAACGTCAACGTATTCATAAAGTTTATGACCCAGTTGATGAGTTAGATGGGCAGGAACGGGAAATGAGAGAAATTACACCGGGGCATTTTGTTTTAGCAACAGAAGAAGAGGCAAAAGCCTATAAGAAAAAATAA","8.10","2.67","34829","MTENRKKLVEVKNVSLTFNKGKANQVKAIDNVSFNIYEGEVFGLVGESGSGKTTIGRAILKLYNIDKGEIDFEGETISKLKGKSLFNFRKKAQMIFQDPQASLNSRMKVRDIIAEGLDVHKLVKNKADRDAKVQDLLDLVGLNKDHLTRYPHEFSGGQRQRIGIARALAVEPKFIIADEPISALDVSIQAQVVNLMQKLQHEQGLTYLFIAHDLSMVKYISDRIGVMHWGKIVEIGTSDEVYHHPIHPYTQSLLSAVPEPDPVLERQRIHKVYDPVDELDGQEREMREITPGHFVLATEEEAKAYKKK","249511","For other components see SMu0234 (NBD2); SMu0233 (MSD1); SMu0232 (MSD2) and SMu0231 (SBP1).For other 'opp' genes see SMu0231 (oppA); SMu0232 (oppB); SMu0233 (oppC) and SMu0234 (oppD).","oligopeptide ABC transporter, ATP-binding","Cytoplasm, Membrane","This sequence corresponds to the previously sequenced gi1661187 and gi2492547 in GenBank, predicted OPPF_STRMU.Matches in gapped BLAST to oligopeptide ABC transporter, ATP-binding proteins. Residues 1-295 are 75% similar to gi14289334 from L.lactis. Residues 42-296 are 80% similar togi13897316 from S.uberis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0152 (1e-146).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[153-196]T$	ABC_transporter
PF00005	$\"[39-230]T$	ABC_tran
PS00211	$\"[154-168]T$	ABC_TRANSPORTER_1
PS50893	$\"[9-254]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[38-231]T$	AAA

InterPro
IPR013563
Domain

Oligopeptide/dipeptide ABC transporter, C-terminal
PF08352	$\"[233-308]T$	oligo_HPY

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-263]T$	G3DSA:3.40.50.300
PTHR19222	$\"[9-295]T$	PTHR19222
PTHR19222:SF28	$\"[9-295]T$	PTHR19222:SF28
SSF52540	$\"[8-278]T$	SSF52540

","BeTs to 10 clades of COG1124COG name: ABC-type dipeptide/oligopeptide/nickel transport system, ATPase componentFunctional Class: E,PThe phylogenetic pattern of COG1124 is a-TK-qV-EB-HujGPo-IN-Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3e-29. IPB001140A 28-74 IPB001140B 151-189 IPB001140C 206-235","Residues 199-237 are 82% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9CIK8_LACLA.Residues 202-256 are 49% similar to a (ATP-BINDING PROTEOME COMPLETE TRANSPORT) protein domain (PD402931) which is seen in O53112_MYCHO.Residues 8-59 are 50% similar to a (ATP-BINDING SAPD PEPTIDE TRANSPORT) protein domain (PD028306) which is seen in Q9LA45_SHIDY.Residues 94-151 are 75% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9CIK8_LACLA.Residues 199-254 are 44% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER) protein domain (PD019551) which is seen in Q9PLN8_CHLMU.Residues 272-295 are 91% similar to a (PROTEOME BINDING OLIGOPEPTIDE COMPLETE) protein domain (PD373216) which is seen in Q9CIK8_LACLA.Residues 239-274 are 61% similar to a (ATP-BINDING TRANSPORT OLIGOPEPTIDE) protein domain (PD245543) which is seen in OPPF_BACSU.Residues 89-142 are 50% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD261527) which is seen in Q9KT10_VIBCH.Residues 197-242 are 43% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472) which is seen in Q9V286_PYRAB.Residues 198-259 are 41% similar to a (SAPD TRANSPORT ATP-BINDING PEPTIDE) protein domain (PD407079) which is seen in O86190_ERWCH.Residues 99-253 are 24% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 29-80 are 72% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CIK8_LACLA.Residues 201-262 are 35% similar to a (ATP-BINDING TRANSPORT PEPTIDE PROTEOME) protein domain (PD259958) which is seen in O67885_AQUAE.Residues 153-196 are 93% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CIK8_LACLA.Residues 89-152 are 50% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE ABC OLIGOPEPTIDE) protein domain (PD000720) which is seen in Q9HMX3_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 14:58:43 2006","Tue Jan 8 15:42:50 2002","Tue Sep 5 14:55:56 2006","Tue Apr 9 08:34:22 2002","Tue Jan 8 15:42:50 2002","Tue Jan 8 15:42:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0235 is paralogously related (blast p-value < 1e-3) to SMu0234, SMu1762, SMu0517, SMu0849, SMu1003, SMu0418, SMu1950, SMu1920, SMu0218, SMu0884, SMu1380, SMu0971, SMu0731, SMu1949, SMu1079, SMu0594, SMu1210, SMu0805, SMu1518, SMu1246, SMu1231, SMu1428, SMu1068, SMu0944, SMu1036, SMu1751, SMu0786, SMu1001, SMu1288, SMu0476, SMu0907, SMu0164, SMu1517, SMu0916, SMu1316, SMu1410, SMu0475, SMu1649, SMu0836, SMu0825, SMu1710, SMu0976, SMu0950, SMu0258, SMu1037, SMu0390, SMu0374, SMu1757, SMu0335, SMu1064, SMu0596, SMu0986, SMu0987, SMu0224, SMu0024, SMu1023, SMu0824, SMu1065, SMu0837, SMu0216, SMu1545, SMu0666, SMu1811, SMu1959, SMu0752, SMu1724, SMu1093, SMu1050, SMu0823, SMu1306, SMu0729, and SMu1202, all ATP-binding proteins.","Sun Jan 13 13:50:57 2002","Tue Sep 5 14:55:56 2006","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 126 3e-030pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 122 6e-029","SMU.259","","Residues 39 to 230 (E-value = 8e-58) place SMu0235 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jan 8 15:42:50 2002","24378767","","","","Mon Oct 28 14:11:01 2002","","1","","","SMU.259","239" "SMu0236","250170","250772","603","ATGTCAAATTTTTTAGATTTACAAAAACAACGTCGCAGTATCTATGCCTTAGGCAAAACTGTTGATTTATCAAAGGCTGAATTAGTTGCATTAATTCAAAATGCCATTAAGCAGGCGCCGTCAGCTTTTAATTCGCAAACCAGCCGTGCTCTCGTTCTTTTCGGGCAAGACTCTCAAGATTTTTGGAATAAAATTGCTTACAGTGAATTAGAAAAAGTCACACCAGCAGAAGCCTTTGCAGGGACAAAAGCGAAGTTGGAAAGTTTTGCTGCTGGAGTTGGAACCATTCTGCTATTTGAAGATCAAGCTGTTGTCAGAAATTTAGAAGAAAACTTTCCGCTTTATGCAGAGAATTTCCAGCCTTGGTCTGAACAAGCACACGGTATTGCTCTTTATGCTATTTGGTTAGCACTAGCTGAACAAAATATTGGTATGAGTGTTCAGCACTACAATCCGCTTGTTGATGCTCAAGTTGCTGAAAAATATGATTTACCAACTAACTGGAAAATGCGTGCACAAATACCTTTTGGTTCAATTGAAGCACCTGCTGGTGAGAAAGAATTCATGGCAGACCAAGAACGTTTCAAAGTATTTGGTGACTAG","4.80","-6.51","22369","MSNFLDLQKQRRSIYALGKTVDLSKAELVALIQNAIKQAPSAFNSQTSRALVLFGQDSQDFWNKIAYSELEKVTPAEAFAGTKAKLESFAAGVGTILLFEDQAVVRNLEENFPLYAENFQPWSEQAHGIALYAIWLALAEQNIGMSVQHYNPLVDAQVAEKYDLPTNWKMRAQIPFGSIEAPAGEKEFMADQERFKVFGD","250769","","conserved hypothetical protein","Periplasm, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 4-200 are 59% similar to gi|15597771 from P.aeruginosa. Residues 2-198 are 51% similar to gi|16802020 from L.inocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1909 (4e-55).","

InterPro
IPR000415
Family

Nitroreductase
PF00881	$\"[8-178]T$	Nitroreductase

noIPR
unintegrated

unintegrated
G3DSA:3.40.109.10	$\"[2-199]T$	G3DSA:3.40.109.10
SSF55469	$\"[1-198]T$	SSF55469

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-189 are 58% similar to a (PROTEOME COMPLETE NMA2195 FUS1-AGP1) protein domain (PD105602) which is seen in Q9I0R1_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 00:07:57 2002","Tue Jan 8 15:45:33 2002","Mon Oct 28 00:07:57 2002","Tue Jan 8 15:45:33 2002","","Tue Jan 8 15:45:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0236 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 28 00:07:57 2002","","No significant hits to the NCBI PDB database.","SMU.260","","No significant hits to the Pfam 11.0 database","Tue Jan 8 15:45:33 2002","24378768","","","","","","1","","","SMU.260","862" "SMu0237","251945","250989","957","ATGAAAATTGAACTCATCTATATCTATAATCTATTATTAATGATGCTTTATGCCATTACCATGGCCTTTTCTGTAAGCTTCTTTATAAGAGAAAAAAAGAAGACACTTTACTTAGTCACTTCTCTTTATCTGCTCTTTTTTATCTTAGATAATTCTGTTATTTCAATGACTGAAATTATTTCAAGTTTTGCTTCCAATTACAACAGTTCCTTTCAAGGAACTTCTTTCATTAAAACAACTGTTTTTCTCGTTAACAACTTTTGTCAGTTATGGATTGTTCATTATTTAAGTAAACGGAAAATGCCTTGGTGGGAATACCTCATCTTACTAGCTATTTTTCTCTTTATGCTCTTACCATCACTACCATCACTGCCCAATACAGCTACAAAGGTATACCTCTATTACCTACCAAATCAATTGCTTCTGTTTTATACAGGCTTGATAGCCTTTTTCAATAGTAAGAAGGAAAATGTAAGCAAGTTAGGTAAAAAATATTTAAAATTAATCGCTTTGCTAGCTATGATTGCCAGTGTTGCTATTTTAATTGAGGACACTTTTGTTATTTTCACTGTTGATCAATACAGTATTTTTAATACAAAAATTATGAATCGAAATGTTTCAGAAGATCTCTTTTCCATCATTGCCTGCTGGCTTCTTCTTTATTATTTTTTAAAAGATTATCCTCTCTTGGAAAAAAGAAACCAAGCTTTACAAACAAAGGCTTTATCTAAAGATGCTATTCAAGACTTTTTTGACTATTACCACTTGACAGAACGAGAACAAGACATTTGCCAACTTTTGCTGGAACATAAACAAAATCAAGAGATTGCTAAGGAACTTTACCTCTCTGTTGGCACAGTAAAAACTCACATTCACAATATTTATATCAAGATGGCCATCAATAAACGAGAACAATTCTTTTCCTTGTACAAAGACTATTTTGCAGAACACCCGTAA","9.60","7.30","37611","MKIELIYIYNLLLMMLYAITMAFSVSFFIREKKKTLYLVTSLYLLFFILDNSVISMTEIISSFASNYNSSFQGTSFIKTTVFLVNNFCQLWIVHYLSKRKMPWWEYLILLAIFLFMLLPSLPSLPNTATKVYLYYLPNQLLLFYTGLIAFFNSKKENVSKLGKKYLKLIALLAMIASVAILIEDTFVIFTVDQYSIFNTKIMNRNVSEDLFSIIACWLLLYYFLKDYPLLEKRNQALQTKALSKDAIQDFFDYYHLTEREQDICQLLLEHKQNQEIAKELYLSVGTVKTHIHNIYIKMAINKREQFFSLYKDYFAEHP","250992","","transcriptional regulator","Membrane, Cytoplasm","Limited matches in gapped BLAST to transcriptional regulators. Residues 19-313 are 36% similar to gi|15673683, a predicted two-component regulator from L.lactis. Residues 254-305 are 50% similar to residues 159-210 of gi|16330984 from Synechocystis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0322 (9e-08).","

InterPro
IPR000792
Domain

Bacterial regulatory protein, LuxR
PD000307	$\"[256-304]T$	HTH_LuxR
PR00038	$\"[256-270]T$ $\"[270-286]T$ $\"[286-298]T$	HTHLUXR
PF00196	$\"[256-298]T$	GerE
SM00421	$\"[253-310]T$	HTH_LUXR
PS50043	$\"[249-314]T$	HTH_LUXR_2

InterPro
IPR009080
Domain

Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
SSF47323	$\"[78-197]T$	tRNAsyn_1a_bind

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[229-310]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46894	$\"[252-313]T$	SSF46894

","BeTs to 3 clades of COG2197COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG2197 is -------CEBRh---------Number of proteins in this genome belonging to this COG is 4","***** IPB000792 (Bacterial regulatory protein, LuxR family) with a combined E-value of 1.1e-17. IPB000792 256-302","Residues 19-262 are 32% similar to a (PROTEOME SYSTEM COMPLETE REGULATOR) protein domain (PD401133) which is seen in Q9CEY3_LACLA.Residues 257-305 are 61% similar to a (DNA-BINDING TRANSCRIPTION REGULATION REGULATOR) protein domain (PD000307) which is seen in Q9CEY3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:17:45 2002","Thu Apr 25 15:37:14 2002","Tue Jan 8 15:50:22 2002","Thu Apr 25 15:37:14 2002","Tue Jan 8 15:49:30 2002","Tue Jan 8 15:49:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0237 is paralogously related (blast p-value < 1e-3) to SMu0441, and SMu1406, both predicted response regulators.","Tue Jan 8 15:50:22 2002","Tue Jan 8 15:49:30 2002","pdb|1A04|A Chain A, The Structure Of The NitrateNITRITE RESPON... 95 1e-020","SMU.261c","","Residues 253 to 310 (E-value = 9.2e-07) place SMu0237 in the GerE family which is described as Bacterial regulatory proteins, luxR family (PF00196)","Tue Jan 8 15:49:30 2002","24378769","","","","","","1","","","SMU.261c","" "SMu0238","252184","253203","1020","ATGATGAAAAAAACAGATTATATTACGACAGAGGATTTTTCTAAAGAAGAATTGCTAAAATTGGTAGATTTATCTTTAAAAATCAAGGCCTGTATCAAAAATGGCTACTATCCCCCCTTATTGGAACACAAAAGTTTAGGGATGATTTTTCAACAAACCTCAACACGAACACGTGTTTCCTTTGAAACAGCCATGAGCCAACTTGGAGGTCATGCACAATATTTAGCACCGGGACAAATTCAGCTTGGAGGTCATGAAACGATTGAGGATACGTCAACTGTTCTTTCCCGATTGGATGATATCTTAATGGCCCGTGTTGAACGTCACCAAAGTGTAGTAGACTTGGCTAGATGTGCTTCTATTCCAGTTATTAACGGGATGTCTGATTATAATCATCCAACTCAGGAACTTGGAGATCTCTGTACAATGATAGAACATTTGCCAGCTGGTAAAAAGTTAGAAGATTGCAAAGTTGTCTTTGTTGGAGATGCGACACAGGTTTGTTTTTCTCTTGCTCTAATAACGACTAAAATGGGAATGGAATTTGTTCACTTTGGACCTAAAGGATTTCAATTAAACGACATGCATAAGGAAAAGTTAGATAAAATTTGTGAACGATCTGGTGGAAAATACACTGTAACTGATAATGAAGATGCCATTGAAGGTGCTGATTTCCTTTATACAGATGTTTGGTATGGTCTATACGAAGCAGAATTATCTGAGGAAGAACGGATGCAAATTTTCTTCCCTAAATATCAAGTCGATAGTCAAATGATGGCTAAAGCTGGTGCGGACTGCAAATTCATGCATTGCTTGCCAGCAACTCGTGGTGAAGAGATTACAGATGAAGTGATGGACGGTCCTCATTCTATTTGCTTTGACGAAGCAGAAAATCGTTTGACTTCCATTAGAGGATTGCTCGTTTATCTTTTAAGGGATTATAGGGAAAAGAATCCTTATGATTTAGTGAAGCAGGAAAAGGCTAAGGAAGAATTAGAAACTTTTTTGAAGCCGGAATAG","4.90","-15.98","38507","MMKKTDYITTEDFSKEELLKLVDLSLKIKACIKNGYYPPLLEHKSLGMIFQQTSTRTRVSFETAMSQLGGHAQYLAPGQIQLGGHETIEDTSTVLSRLDDILMARVERHQSVVDLARCASIPVINGMSDYNHPTQELGDLCTMIEHLPAGKKLEDCKVVFVGDATQVCFSLALITTKMGMEFVHFGPKGFQLNDMHKEKLDKICERSGGKYTVTDNEDAIEGADFLYTDVWYGLYEAELSEEERMQIFFPKYQVDSQMMAKAGADCKFMHCLPATRGEEITDEVMDGPHSICFDEAENRLTSIRGLLVYLLRDYREKNPYDLVKQEKAKEELETFLKPE","253200","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0607 (argB);SMu0608 (argD); SMu1904 (argS);SMu1903 (argR); SMu1900 (argR); SMu0300 (argG) and SMu0301 (argH).","ornithine carbamoyltransferase","Cytoplasm","Numerous matches in gapped BLAST to ornithine carbamoyltransferases. Residues 4-336 are 78% similar to gi:15673682 from L.lactis. Residues 1-337 are 65% similar to gi16802084 from L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2165 (8e-47).","

InterPro
IPR002292
Family

Ornithine carbamoyltransferase
PR00102	$\"[48-62]T$ $\"[81-94]T$ $\"[121-135]T$ $\"[226-236]T$ $\"[290-301]T$	OTCASE
TIGR00658	$\"[5-312]T$	orni_carb_tr: ornithine carbamoyltransferas

InterPro
IPR006130
Family

Aspartate/ornithine carbamoyltransferase
PR00100	$\"[50-69]T$ $\"[132-143]T$ $\"[264-273]T$ $\"[276-299]T$	AOTCASE
PIRSF000416	$\"[5-317]T$	Ornithine/aspartate carbamoyltransferase

InterPro
IPR006131
Domain

Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region
PF00185	$\"[153-310]T$	OTCace

InterPro
IPR006132
Domain

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
PF02729	$\"[5-146]T$	OTCace_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1370	$\"[135-313]T$	no description
PIRSF500170	$\"[5-313]T$	Ornithine carbamoyltransferase
PTHR11405	$\"[133-323]T$	CARBAMOYLTRANSFERASE RELATED
PTHR11405:SF1	$\"[133-323]T$	ORNITHINE CARBAMOYLTRANSFERASE

","BeTs to 13 clades of COG0078COG name: Ornithine carbamoyltransferaseFunctional Class: EThe phylogenetic pattern of COG0078 is amtkyqvcEbrh---po----Number of proteins in this genome belonging to this COG is 2","***** IPB002029 (Aspartate and ornithine carbamoyltransferase family) with a combined E-value of 1.2e-48. IPB002029A 43-70 IPB002029B 80-105 IPB002029C 122-160 IPB002029D 262-283","Residues 8-145 are 81% similar to a (CARBAMOYLTRANSFERASE ASPARTATE ORNITHINE BIOSYNTHESIS) protein domain (PD000708) which is seen in Q9CEY4_LACLA.Residues 252-313 are 75% similar to a (ORNITHINE CARBAMOYLTRANSFERASE ARGININE OTCASE CATABOLIC) protein domain (PD244504) which is seen in Q9CEY4_LACLA.Residues 160-311 are 43% similar to a (ASPARTATE CARBAMOYLTRANSFERASE BIOSYNTHESIS ORNITHINE) protein domain (PD124925) which is seen in OTC_METTH.Residues 146-251 are 80% similar to a (PROTEOME CARBAMOYLTRANSFERASE COMPLETE) protein domain (PD394832) which is seen in Q9CEY4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 24 07:47:01 2005","Tue May 24 07:47:01 2005","Tue May 24 07:47:01 2005","Wed Apr 3 09:29:27 2002","Tue Jan 8 15:53:45 2002","Tue Jan 8 15:53:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0238 is paralogously related (blast p-value < 1e-3) to SMu0512, also a predicted OTCase, and SMu0782, a predicted aspartate transcarbamoylase.","Tue Jan 8 16:07:00 2002","Tue Feb 1 12:06:34 2005","pdb1A1S Ornithine Carbamoyltransferase From Pyrococcus Fur... 235 5e-063pdb1C9YA Chain A, Human Ornithine Transcarbamylase: Crystallo... 200 2e-052pdb1DXHA Chain A, Catabolic Ornithine Carbamoyltransferase Fr... 196 5e-051","SMU.262","","Residues 5 to 147 (E-value = 2.3e-46) place SMu0238 in the OTCace_N family which is described as Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain (PF02729)Residues 153 to 311 (E-value = 4.1e-36) place SMu0238 in the OTCace family which is described as Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain (PF00185)","Tue Feb 1 12:06:34 2005","24378770","","Griswold AR, Chen YY, Burne RA.Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159.J Bacteriol. 2004 Mar;186(6):1902-4.PMID: 14996823","Mountain,A., Smith,M.C. and Baumberg,S.Nucleotide sequence of the Bacillus subtilis argF gene encodingornithine carbamoyltransferaseNucleic Acids Res. 18 (15), 4594 (1990)PubMed: 2117745O'Reilly,M. and Devine,K.M.Sequence and analysis of the citrulline biosynthetic operon argC-F from Bacillus subtilisMicrobiology 140 (Pt 5), 1023-1025 (1994)PubMed: 8025667","Tue Feb 1 12:08:10 2005","Tue May 24 07:47:01 2005","1","","","SMU.262","" "SMu0239","253301","254659","1359","ATGGAAGGAAAGAAAAAATTTAGTTTATTTAGTGCAGTACTTTCTGTTATTTGTGTCGTCTTTGTTGCTGAAGCGGCTGCTCCGGTAGCTGCTATTGGGAATTCTCAATTCTTTTGGTGGCTCTTTTTATTAATTGCCTTTCTTCTACCTTATGGTTTGATTTCATCTGAATTGGGAACAACTTATATTGGTGATGGTGGTATCTATGATTGGGTGACCAAGGCTTTTGGTCATAAATGGGGCTCTCGAGTGGCTTGGTATTATTGGATTAATTTTCCACTCTGGCTAGCTTCTCTGGCAGTTATGACACCGGGTTTATTAACAACAGTTACTGGACACAACTTTTCAACTGTTACAGCTATTATTGTTGAACTCATTTTTATTTGGCTGGTTATTTGGATTAGTTTTTATCCCGTGAGTGATAGTATTTGGATTTTAAATGGTGCAGCTGTCATTAAAATGTTATTGGCCTTACTTGTTGGTGGCTTGGGCCTTTATGTGGCCCTGACCAAGGGCATGGCAAATGAAATGACCTTAAAGTCACTGTTGCCTTCTTTTAATCTGAACAGTCTCTCTTATATTTCAGTTATTATTTTTAACCTGCTCGGTTTTGAGGTTATTTGTACTTTTGCAGGAGATATGGAAAATCCTAAAAAGCAAATTCCTCAATCTATTATTGTTGCAGGTCTGGTAATTGCAGCTATCTATATTTTTTCTGCTTTTGGTATTGGCGTCTCAATTCCAACGGATAAGATTTCAACCAGCAGTGGTATGATGGATAGTTTTAAATTATTAACAGGCTCAACGGGCGGTTGGTTTATCATGACCATGGCTTTTCTATTTTTATTGACCTTGTTTGGCAATATGATTTCTTGGTCTCTCGGTGTTAATAATACAGCTTCTTATGCTGCAGAAAATGGAGACATGCCCCAATTTTTTGCTAAAAGAAGTCGCAAAAGAGATATGCCAATTGGTGCTGCTCTTGCTAATGGTATTGTTGCTAGCATTGTGGTTGTTATTGCCCCATTTTTGCCCAATCAAGATTTATTCTGGGCTTTCTTCTCCTTAAACTTAGTCATGTTTTTATTGTCTTATGTTCCTGTATTTCCAGCATTTTTCAAGTTGAGAAAAATAGATCCGGATACACCGCGTCCTTTTAAGGTTAGTGGCAATGATAGTTTTTTGAGATTACTTGTTATTTTACCAATGATTTTAATTATCATTTCCTTGATTTTTACTGCTCTACCACTGGCTTTTGATTCTGAAACTTTAGCTTCAAAATTACCAATAACAATTGGTTCTCTTATTTTTATAGGGATAGGTGAACTTATTATTATCATCAAAAAAATAAAGAAATGA","9.90","6.38","49592","MEGKKKFSLFSAVLSVICVVFVAEAAAPVAAIGNSQFFWWLFLLIAFLLPYGLISSELGTTYIGDGGIYDWVTKAFGHKWGSRVAWYYWINFPLWLASLAVMTPGLLTTVTGHNFSTVTAIIVELIFIWLVIWISFYPVSDSIWILNGAAVIKMLLALLVGGLGLYVALTKGMANEMTLKSLLPSFNLNSLSYISVIIFNLLGFEVICTFAGDMENPKKQIPQSIIVAGLVIAAIYIFSAFGIGVSIPTDKISTSSGMMDSFKLLTGSTGGWFIMTMAFLFLLTLFGNMISWSLGVNNTASYAAENGDMPQFFAKRSRKRDMPIGAALANGIVASIVVVIAPFLPNQDLFWAFFSLNLVMFLLSYVPVFPAFFKLRKIDPDTPRPFKVSGNDSFLRLLVILPMILIIISLIFTALPLAFDSETLASKLPITIGSLIFIGIGELIIIIKKIKK","254656","","amino acid permease /putrescine antiporter","Membrane, Cytoplasm, Extracellular","Several hits in gapped BLAST to amino acid antiporters. Residues 3-431 are 58% similar to gi15673681 from L.lactis. Residues 1-430 are 46% similar to gi16802085 from L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2166 (1e-10).","

InterPro
IPR002293
Family

Amino acid/polyamine transporter I
PTHR11785	$\"[1-448]T$	AMINO ACID TRANSPORTER

InterPro
IPR004841
Domain

Amino acid permease-associated region
PF00324	$\"[8-424]T$	AA_permease

noIPR
unintegrated

unintegrated
PIRSF006060	$\"[1-452]T$	High-affinity amino acid transporter
PTHR11785:SF78	$\"[1-448]T$	GLUTAMATE/GAMMA-AMINOBUTYRATE ANTI-PORTER
signalp	$\"[1-25]?$	signal-peptide
tmhmm	$\"[9-31]?$ $\"[37-55]?$ $\"[84-104]?$ $\"[114-134]?$ $\"[149-169]?$ $\"[191-211]?$ $\"[226-246]?$ $\"[265-285]?$ $\"[323-343]?$ $\"[349-369]?$ $\"[397-419]?$ $\"[425-447]?$	transmembrane_regions

","BeTs to 10 clades of COG0531COG name: Amino acid transportersFunctional Class: EThe phylogenetic pattern of COG0531 is AMt-Y--cEBRh--GP--INXNumber of proteins in this genome belonging to this COG is 3","***** IPB002027 (Amino acid permease) with a combined E-value of 4.1e-13. IPB002027C 199-237 IPB002027D 283-322","Residues 256-431 are 58% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD400363) which is seen in Q9CEY5_LACLA.Residues 66-154 are 30% similar to a (ACID AMINO PROTEOME COMPLETE) protein domain (PD000214) which is seen in Q9HV05_PSEAE.Residues 3-178 are 52% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD399919) which is seen in Q9CEY5_LACLA.Residues 193-255 are 84% similar to a (TRANSPORT AMINO ACID AMINO-ACID PERMEASE TRANSMEMBRANE) protein domain (PD000442) which is seen in Q9CEY5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:01:09 2002","Tue Feb 1 12:09:39 2005","Tue Feb 1 12:09:39 2005","Tue Feb 1 12:09:39 2005","Tue Jan 8 16:08:14 2002","Tue Jan 8 16:08:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0239 is paralogously related (blast p-value < 1e-3) to SMu1320, SMu0014, and SMu0863, predicted amino acid permeases.","Tue Jan 8 16:19:44 2002","","No significant hits to the NCBI PDB database.","SMU.263","","Residues 7 to 451 (E-value = 9.2e-05) place SMu0239 in the AA_permease family which is described as Amino acid permease (PF00324)","Tue Jan 8 16:08:14 2002","24378771","","Griswold AR, Chen YY, Burne RA.Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159.J Bacteriol. 2004 Mar;186(6):1902-4.PMID: 14996823","","Tue Feb 1 12:09:39 2005","","1","","","SMU.263","" "SMu0240","254669","255778","1110","ATGGCAAAACGTATTAAAAATACAACTCCAAAACAAGATGGCTTTAGAATGCCAGGTGAATTTGAAAAACAAAAACAAATTTGGATGCTTTGGCCTTGGCGCAATGATAATTGGCGGTTGGGAGCTAAACCTGCTCAAAAGGCTTTTTTAGAAGTAGCTGAGGCTATTAGTGAGTTCGAGCCTGTCTCTCTTTGTGTTCCGCCACTGCAATATGAAAATGCTTTGGCTCGCGTATCAGAATTGGGTAGTCATAATATTCGAATTATTGAAATGACCAATGATGATGCTTGGATTCGTGACTGTGGTCCAACATTTCTGGTGAATGACAAAGGAGATTTGCGTGCGGTTGATTGGGAATTCAATGCCTGGGGAGGCTTAGTCGATGGTCTTTATTTTCCTTGGGACCAAGATGCTTTAGTAGCACGTAAGGTTTGTGAAATAGAAGGTGTGGATTCTTACAAAACGAAAGATTTTGTTCTTGAAGGAGGTTCTATCCATGTGGATGGCGAAGGAACCGTTTTGGTAACAGAAATGTGTCTGTTACATCCTAGTCGTAATCCGCATCTGACCAAAGAAGATATTGAAGATAAATTGAAGGACTATCTTAATTGTGTAAAGGTTCTTTGGGTCAAGGATGGCATTGATCCTTATGAAACGAATGGTCATATTGATGATGTTGCCTGCTTTATTCGTCCGGGGGAAGTTGCCTGCATCTATACAGATGATAAGGAACATCCTTTTTATCAGGAAGCTAAAGCAGCTTATGACTTCTTGTCTCAACAGACAGATGCCAAGGGACGTCCTTTAAAGGTTCATAAAATGTGCGTGACCAAGGAACCCTGTTATCTGCAGGAAGCTGCAACCATTGACTATGTTGAAGGCAGTATTCCACGTGAAGAAGGAGAAATGGCGATTGCCTCTTATTTGAATTTCTTGATTGTTAATGGAGGGATTATTTTACCGCAGTATGGGGATGAAAATGATCAACTAGCTAAACAGCAGGTACAGGAAATGTTTCCAGATAGAAAAGTCGTTGGTGTGAGAACAGAAGAAATTGCTTACGGTGGTGGCAATATTCACTGTATTACACAACAGCAACCTGCAACTTAA","4.70","-19.51","41825","MAKRIKNTTPKQDGFRMPGEFEKQKQIWMLWPWRNDNWRLGAKPAQKAFLEVAEAISEFEPVSLCVPPLQYENALARVSELGSHNIRIIEMTNDDAWIRDCGPTFLVNDKGDLRAVDWEFNAWGGLVDGLYFPWDQDALVARKVCEIEGVDSYKTKDFVLEGGSIHVDGEGTVLVTEMCLLHPSRNPHLTKEDIEDKLKDYLNCVKVLWVKDGIDPYETNGHIDDVACFIRPGEVACIYTDDKEHPFYQEAKAAYDFLSQQTDAKGRPLKVHKMCVTKEPCYLQEAATIDYVEGSIPREEGEMAIASYLNFLIVNGGIILPQYGDENDQLAKQQVQEMFPDRKVVGVRTEEIAYGGGNIHCITQQQPAT","255775","","agmatine deiminase","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-367 are 66% similar to gi15673679 from L.lactis. Residues 4-367 are 56% similar to gi16802086 from L.monocytogenes.SMu0240 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007466
Family

Porphyromonas-type peptidyl-arginine deiminase
PF04371	$\"[15-367]T$	PAD_porph

noIPR
unintegrated

unintegrated
G3DSA:3.75.10.10	$\"[3-367]T$	G3DSA:3.75.10.10
SSF55909	$\"[7-368]T$	SSF55909

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 20-367 are 65% similar to a (PROTEOME COMPLETE CJ0949C YRFC) protein domain (PD041198) which is seen in Q9CEY6_LACLA.Residues 1-365 are 19% similar to a (IMMUNOREACTIVE PG96 ANTIGEN) protein domain (PD361199) which is seen in Q9XBW3_PORGI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 1 12:11:39 2005","Tue Feb 1 12:11:39 2005","Tue Feb 1 12:11:39 2005","Tue Jan 8 16:22:12 2002","","Tue Jan 8 16:22:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0240 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 18:21:50 2002","","No significant hits to the NCBI PDB database.","SMU.264","","Residues 15 to 367 (E-value = 9.9e-239) place SMu0240 in the PAD_porph family which is described as Porphyromonas-type peptidyl-arginine deiminase (PF04371)","Tue Jan 8 16:22:12 2002","24378772","","Griswold AR, Chen YY, Burne RA.Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159.J Bacteriol. 2004 Mar;186(6):1902-4.PMID: 14996823","","Tue Feb 1 12:12:56 2005","","1","","","SMU.264","" "SMu0241","255810","256760","951","ATGGCAAAAAGAAAAATTGTCATTGCATTAGGGGGAAATGCAATTTTGTCTAGAGATGCTTCTGCCAAAGCACAGCAGGCAGCATTGGCTCAGACTGCCAAATATCTGGTCCAATTCATTAAAAATGGTGATGATTTAGTCATTACTCATGGGAATGGTCCGCAGGTAGGTAATCTGTTATTGCAACAAACAGCTGCTGATTCTTATGACAATCCAGCGCTTCCCTTGGATACCCTAGTGGCCATGACAGAAGGTTCCATTAGTTATTGGTTACAAAATGCCTTAATCAATGAGTTAAGGAAACAATCCATTGATAAGGAAGTTGTGTCTATGGTAACAGAAGTACTTGTATCAGCCGAAGATCCCGCTTTTGACCATCCCAGTAAACCCATCGGTCCTTTTCTTAGTGAGGAAGAAGCCTATCTGCAAGAAAAGATGACTGGTGCTACTTATAAAGTAGATGCAGGCAGAGGTTGGCGAAAAGTAGTTGCTTCTCCCAAGCCAATTGCCATTCAGGAAATAGCAACGATAAAATCTTTGCTTAATACAGGAGCTGTTGTTATTACAGCAGGTGGCGGTGGCATTCCGGTTATTGAAGACCCTAAAACAAAAGAATTAATGGGTGTGGAAGCTGTTATTGATAAAGATTTTGCCAGTCAATTATTGGCCGAAAAAATCAAAGCTGATTTATTTATTATTTTGACTGGTGTTGATCATGTTTATATTCATTATGGTCAACCTAATCAAGAAAAATTAGAAAAAGTAACAGCAAGTCAGCTAAAAGCATGGAAGGATCAACAACAATTTGCAGCAGGTAGCATGCTACCAAAAGTAGAAGCAGCAATTGCCTTTGTTGAAGCACATCCCAGTGGAAAAGCCATTATTACTTCTTTAGAAAATATAGCAAATGTTATTTCAGAAGGAAGTGGCACACAAATTACGGCTAATTAA","5.30","-5.78","33784","MAKRKIVIALGGNAILSRDASAKAQQAALAQTAKYLVQFIKNGDDLVITHGNGPQVGNLLLQQTAADSYDNPALPLDTLVAMTEGSISYWLQNALINELRKQSIDKEVVSMVTEVLVSAEDPAFDHPSKPIGPFLSEEEAYLQEKMTGATYKVDAGRGWRKVVASPKPIAIQEIATIKSLLNTGAVVITAGGGGIPVIEDPKTKELMGVEAVIDKDFASQLLAEKIKADLFIILTGVDHVYIHYGQPNQEKLEKVTASQLKAWKDQQQFAAGSMLPKVEAAIAFVEAHPSGKAIITSLENIANVISEGSGTQITAN","256757","For other 'arc' genes see SMu0512 (arcB); SMu0740 (arcT) and SMu1901 (arcE). ","carbamate kinase","Cytoplasm, Membrane","Several matches in gapped BLAST to carbamate kinase sequences. Residues 1-315 are 60% similar to gi15675439 from S.pyogenes. Residues 4-3115 are 56% similar to gi16802087 from L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2167 (1e-107).","

InterPro
IPR001048
Domain

Aspartate/glutamate/uridylate kinase
G3DSA:3.40.1160.10	$\"[2-315]T$	no description
PF00696	$\"[4-297]T$	AA_kinase

InterPro
IPR003964
Family

Bacterial carbamate kinase
PR01469	$\"[43-62]T$ $\"[75-93]T$ $\"[110-129]T$ $\"[159-178]T$ $\"[182-200]T$ $\"[214-229]T$ $\"[269-284]T$	CARBMTKINASE
PIRSF000723	$\"[4-315]T$	Carbamate kinase
TIGR00746	$\"[4-315]T$	arcC: carbamate kinase

","BeTs to 4 clades of COG0549COG name: Carbamate kinaseFunctional Class: EThe phylogenetic pattern of COG0549 is ---k---cE--h---p-----Number of proteins in this genome belonging to this COG is 1","***** IPB001057 (Glutamate 5-kinase) with a combined E-value of 8.5e-13. IPB001057A 29-54 IPB001057C 212-245 IPB001057D 264-296","Residues 213-313 are 50% similar to a (KINASE CARBAMATE TRANSFERASE METABOLISM) protein domain (PD400834) which is seen in ARCC_LACSK.Residues 5-168 are 59% similar to a (KINASE CARBAMATE TRANSFERASE METABOLISM) protein domain (PD004953) which is seen in ARCC_ENTFC.Residues 213-313 are 52% similar to a (KINASE CARBAMATE TRANSFERASE COMPLETE) protein domain (PD414861) which is seen in Q9CE17_LACLA.Residues 205-300 are 47% similar to a (KINASE ACETYLGLUTAMATE TRANSFERASE NAG AGK ARGININE) protein domain (PD003894) which is seen in Q9HII9_THEAC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 13 14:46:13 2007","Wed Jan 9 11:08:48 2002","Tue Feb 1 12:14:53 2005","Thu Apr 4 14:43:03 2002","Wed Jan 9 09:19:27 2002","Wed Jan 9 09:19:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0241 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 10:51:46 2002","Tue Feb 1 12:14:53 2005","pdb1B7BA Chain A, Carbamate Kinase From Enterococcus Faecium ... 316 2e-087pdb1E19A Chain A, Structure Of The Carbamate Kinase-Like Carb... 230 1e-061","SMU.265","","Residues 4 to 297 (E-value = 1.9e-83) place SMu0241 in the AA_kinase family which is described as Amino acid kinase family (PF00696)","Wed Jan 9 09:19:27 2002","24378773","","Griswold AR, Chen YY, Burne RA.Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159.J Bacteriol. 2004 Mar;186(6):1902-4.PMID: 14996823","Tonon T, Bourdineaud JP, Lonvaud-Funel A.The arcABC gene cluster encoding the arginine deiminase pathway of Oenococcus oeni, and arginine induction of a CRP-like gene.Res Microbiol. 2001 Sep;152(7):653-61.PMID: 11605985Marina A, Alzari PM, Bravo J, Uriarte M, Barcelona B, Fita I, Rubio V.Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine.Protein Sci. 1999 Apr;8(4):934-40.PMID: 10211841Marina A, Uriarte M, Barcelona B, Fresquet V, Cervera J, Rubio V.Carbamate kinase from Enterococcus faecalis and Enterococcus faecium--cloning of the genes, studies on the enzyme expressed in Escherichia coli, and sequence similarity with N-acetyl-L-glutamate kinase.Eur J Biochem. 1998 Apr 1;253(1):280-91.PMID: 9578487","Tue Mar 13 14:46:13 2007","Wed Jan 9 11:13:52 2002","1","","","SMU.265","" "SMu0242","259536","257272","2265","ATGCACATCAATCAATTATTACAGCATGCAAATTCTGACTTACCCCTTCTTCAAGCTAATTTTGGTTTAGAAAGAGAAAGTCTCCGTATCAATAAAACAAATCACCGGCTGGCTCAGACACCTCATCCAACAGCACTGGGTTCTCGCCAGTTTCATCCTTATATTCAAACAGATTACAGTGAGTCTCAGATGGAACTAATCACGCCTGTCGCTCATTCCAGCAAGGAAGTCCTTCGTTTTTTAGGGGCTATTACTGATGTTGCAGAGCGCAGTATTGACCAAAACCAATACCTTTGGCCTTTGTCTATGCCGCCTCAAATTACAGAAGACGAAATTGAAATTGCCCAGTTAGAAGATGACTTTGAATTTTCCTATCGTCAGTATTTAGATAAAAAATATGGAAAAATCCTGCAATCCATATCTGGCATTCATTATAACATGGAGCTAGGTGCTGATTTAATGAATGAACTTTTTGAACTTAGCGGTTATCAGTCTTTCATTGACTTTAAAAATGATCTCTACTTAAAAGTGGCTCAGAATTTCTTAAACTATCGTTGGTTCCTGACCTACCTTTATGGGGCTAGTCCCTTGGCTGAAAAAGGATTTTTAAATGAAGAGCTCAGCCAAACTGTTCGCTCAATCCGAAACAGTCATTTAGGCTATGTCAATACTGATGATATTAAGGTTCCTTTCGACAGTCTCGAAAATTATATCTCAAGTATTGAGCACTACGTTAAAAGCGGTGCTCTATCAGCTGAAAAAGAATTCTATTCAGCTGTTCGTTTGCGTGGCAGTAAGCATAATCGTGACTATCTTACTAAAGGAATCACTTATTTAGAATTTCGCTGTTTTGATCTTAATCCCTTCAATAATCGCGGCATTACGCAAGAAACCATTGACAGTGTCCATCTCTTTATCTTGGCCATGCTCTGGCTTGACACACCAAAAAAGCTGAATCAAGCACTTGATAAGGCTCAAAAACTTAATGATAAAATTGCATTAAGCCATCCTCTGGAAAAATTACCAAAGGAGAACTCTGCTTCCCTTATTATAGAAGCAATGGAAGCCTTAATTAAACACTTTAAATTACCAAGTTACTATGATGATTTACTAATTGCTATCAAAAAACAAGTTGAAAATCCTAAGTTAACTCTAAGCGGCCGTCTCTTTGAGCATATTAAGCATGCCTCATTGGAGCATTTTGGACAGAAAAAAGGGCAAGATTATCATAACTACGCTTGGCAAAATTATTATGCCCTCAAGGGCTATGAAAATATGGAATTGTCAACACAAATGCTGCTTTTTGATACCATCCAAAAAGGAATTCATTTTGAAATTTTAGATGAAAATGATCAATTTCTCAAACTGTGGCATAATGATCATATTGAATATGTCAAAAATGGCAACATGACTTCTAAAGATAACTACGTTATCCCCCTAGCCATGGCCAATAAAGTGGTGACTAAAAAAATACTAAGAGAAAACGGCTACCCTGTCCCAGCAGGAGCTGAATTTGACAATAAAGACGAGGCCCTCCGCTATTATTCCCAAATCAAAAATAAACCTATTGTTGTTAAACCTAAGACAACCAATTTCGGACTTGGGATTTCTATTTTTGAAACAGCAGCCAGTCACAATGATTACGAAAAAGCACTTGACATTGCCTTTATTGAAGACTATTCGGTCCTTGTGGAAGAATTTATACCAGGAACAGAATACCGTTTCTTCATTCTGGACGGTAAATGTGAGGCCGTTCTCTTGCGGGTTGCGGCCAACGTCGTTGGAGACGGCCATAGTACTGTTCGGCAGCTCGTGGCACAAAAAAATAGGGATCCTCTTCGTGGTCGGGAGCATCGCTCTCCACTTGAAATCATTGATCTCGGTGATATTGAATTGCTGATGCTGCAGCAAGAAGGTTATACCCTAGAAGACATCTTACCAAAGGGCAAGAAGGTGAATCTTCGTGGTAATTCCAATATCTCAACTGGCGGCGATTCGATTGATGTGACAGAAACCATGGATCCTAGCTACAAACAACTAGCAGCTAATATGGCGACAGCAATGGGAGCTTGGGTTTGTGGGGTGGATTTGATCATTCCAGATACCAACTTAAAAGCCAGCAAGGGAAAGCCAAACTGTACCTGCATTGAGCTCAATTTCAATCCATCCATGTATATGCATACCTATTGCTACCAAGGACCGGGACAAGTTATCACAGGCAAAATTCTAGCCAAGCTCTTTCCTGAAATAAGCACCAAGATATAA","6.20","-11.43","86181","MHINQLLQHANSDLPLLQANFGLERESLRINKTNHRLAQTPHPTALGSRQFHPYIQTDYSESQMELITPVAHSSKEVLRFLGAITDVAERSIDQNQYLWPLSMPPQITEDEIEIAQLEDDFEFSYRQYLDKKYGKILQSISGIHYNMELGADLMNELFELSGYQSFIDFKNDLYLKVAQNFLNYRWFLTYLYGASPLAEKGFLNEELSQTVRSIRNSHLGYVNTDDIKVPFDSLENYISSIEHYVKSGALSAEKEFYSAVRLRGSKHNRDYLTKGITYLEFRCFDLNPFNNRGITQETIDSVHLFILAMLWLDTPKKLNQALDKAQKLNDKIALSHPLEKLPKENSASLIIEAMEALIKHFKLPSYYDDLLIAIKKQVENPKLTLSGRLFEHIKHASLEHFGQKKGQDYHNYAWQNYYALKGYENMELSTQMLLFDTIQKGIHFEILDENDQFLKLWHNDHIEYVKNGNMTSKDNYVIPLAMANKVVTKKILRENGYPVPAGAEFDNKDEALRYYSQIKNKPIVVKPKTTNFGLGISIFETAASHNDYEKALDIAFIEDYSVLVEEFIPGTEYRFFILDGKCEAVLLRVAANVVGDGHSTVRQLVAQKNRDPLRGREHRSPLEIIDLGDIELLMLQQEGYTLEDILPKGKKVNLRGNSNISTGGDSIDVTETMDPSYKQLAANMATAMGAWVCGVDLIIPDTNLKASKGKPNCTCIELNFNPSMYMHTYCYQGPGQVITGKILAKLFPEISTKI","257275","","glutamate--cysteine ligase (gamma ECS)","Cytoplasm","Matches in gapped BLAST are to unknowns and to glutamyl-cysteine ligases. Residues 1-750 are 46% similar to gi15602913 from P.multocida. Residues 16-747 are 38% similar to gi16801972 from L.inocua, said to be a gamma-glutamylcysteine synthetase at the N-terminus and a cyanophycin synthetase at the C-terminus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1821 (0.0).","

InterPro
IPR000115
Domain

Phosphoribosylglycinamide synthetase
PF01071	$\"[483-632]T$	GARS_A

InterPro
IPR006335
Family

Glutamate--cysteine ligase related
TIGR01435	$\"[12-747]T$	glu_cys_lig_rel

InterPro
IPR007370
Domain

Glutamate--cysteine ligase
PF04262	$\"[1-332]T$	Glu_cys_ligase

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[489-752]T$	ATP_GRASP

noIPR
unintegrated

unintegrated
PTHR23135	$\"[426-656]T$	PTHR23135
PTHR23135:SF1	$\"[426-656]T$	PTHR23135:SF1
SSF55931	$\"[21-410]T$	SSF55931
SSF56059	$\"[484-750]T$	SSF56059

","BeTs to 6 clades of COG1181COG name: D-alanine-D-alanine ligase and related ATP-grasp enzymesFunctional Class: MThe phylogenetic pattern of COG1181 is -----qvcEbrhuj--olinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 587-701 are 53% similar to a (PROTEOME SYNTHETASE COMPLETE CYANOPHYCIN) protein domain (PD191160) which is seen in Q9CM00_PASMU.Residues 22-313 are 49% similar to a (LIGASE GLUTAMATE--CYSTEINE SYNTHETASE) protein domain (PD043275) which is seen in Q9CM00_PASMU.Residues 331-482 are 45% similar to a (PROTEOME PM1048 COMPLETE) protein domain (PD399226) which is seen in Q9CM00_PASMU.Residues 484-585 are 48% similar to a (LIGASE SYNTHETASE CARBOXYLASE COMPLETE PROTEOME) protein domain (PD000180) which is seen in Q9CM00_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 11:28:29 2002","Tue Oct 22 16:43:23 2002","Thu Aug 24 09:19:53 2006","Tue Oct 22 16:43:23 2002","","Wed Jan 9 11:23:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0242 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 11:28:29 2002","","No significant hits to the NCBI PDB database.","SMU.267c","","Residues 1 to 332 (E-value = 1.8e-89) place SMu0242 in the Glu_cys_ligase family which is described as Glutamate-cysteine ligase (PF04262)","Wed Jan 9 11:23:33 2002","24378774","","","Watanabe,K., Yamano,Y., Murata,K. and Kimura,A.The nucleotide sequence of the gene for gamma-glutamylcysteinesynthetase of Escherichia coliNucleic Acids Res. 14 (11), 4393-4400 (1986)PubMed: 2872655","","Wed Jan 9 11:40:06 2002","1","","7","SMU.267c","186" "SMu0243","259734","261023","1290","ATGACTTCAGTTGTTGTTGTTGGAACCCAGTGGGGAGATGAAGGTAAAGGAAAAATTACCGATTTTTTATCTGCTGATGCAGAAGTGATTGCACGTTATCAGGGTGGAGACAATGCAGGGCATACCATTGTTATCGATGGGAAAAAATTTAAACTGCATTTAATTCCGTCAGGAATTTTCTTTCCTGAAAAGGTTTCTGTTATTGGTAATGGGATGGTTGTCAATCCCAAATCATTGGTTGAAGAATTAGATTATCTTCATCAAGAAGGTGTTGCAACAGATAATCTTCGTATTTCTGATCGTGCCCATATTATTTTGCCTTATCATATTAAACTTGACCAATTACAAGAAGCGTCCAAGGGGGATAATAAAATCGGGACTACTAATAAAGGAATCGGCCCTGCCTATATGGATAAGGCTGCACGCGTTGGTATTCGGATTGCTGACTTGCTTGATAAGGACATTTTTGCAGAACGTCTAAAAGCAAATTTGGCAGAAAAAAATCGCCTTTTTGAAAAAATGTATGAGTCGTCTCCAGTAGCCTTTGATACTATTTTTGATGAGTACTATGCTTATGGTCAAAAGATTAAAGATTATGTCACTGATACCTCTGTTATCCTAAATAAGGCTCTTGATAAAGGGAGACGGGTTCTCTTTGAAGGAGCTCAAGGAGTTATGCTTGATATTGACCAAGGAACCTATCCATTTGTAACTTCATCAAATCCAGTTGCAGGTGGCGTTACCATCGGATCTGGTGTTGGACCAAGTAAAATCAATAAGGTTGTTGGTGTCTGCAAAGCCTATACCAGCCGTGTAGGTGATGGTCCTTTCCCCACAGAACTTTTTGACCAAACGGGAGAGCGCATTCGTGAAGTTGGGCATGAATACGGGACAACAACAGGGCGTCCGCGCCGAGTTGGTTGGTTTGACTCAGTTGTTATGCGTCACAGCCGCCGTGTATCAGGCATTACCAATTTATCTCTTAACTGTATTGATGTACTTTCAGGTCTTGATATCGTAAAAATCTGTGTAGCCTATGATTTGGATGGAAAACGGATTGATCACTACCCTGCCAGTCTCGAACAACTCAAACGCTGTAAACCTATTTATGAAGAATTGCCGGGCTGGTCTGAAGATATTACAGGGGTTCGCAGTTTAGAAGATCTTCCTGAAAATGCTCGTAATTATGTCCGCCGTGTAAGTGAATTAGTTGGTGTTCGTATTTCTACTTTCTCGGTTGGTCCAGATCGTGATCAGACTAATATTTTGGAAAGTGTCTGGGGATTGTAA","6.30","-3.23","47337","MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIFFPEKVSVIGNGMVVNPKSLVEELDYLHQEGVATDNLRISDRAHIILPYHIKLDQLQEASKGDNKIGTTNKGIGPAYMDKAARVGIRIADLLDKDIFAERLKANLAEKNRLFEKMYESSPVAFDTIFDEYYAYGQKIKDYVTDTSVILNKALDKGRRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDQTGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNCIDVLSGLDIVKICVAYDLDGKRIDHYPASLEQLKRCKPIYEELPGWSEDITGVRSLEDLPENARNYVRRVSELVGVRISTFSVGPDRDQTNILESVWGL","261020","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0028 (purF),(purB) ; SMu0030 (purM); SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0054 (purB); SMu0321 (purR).","adenylosuccinate synthetase","Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1818 (0.0).","

InterPro
IPR001114
Family

Adenylosuccinate synthetase
PD001188	$\"[1-81]T$	Asucc_synthtase
PTHR11846	$\"[4-427]T$	Asucc_synthtase
PF00709	$\"[3-422]T$	Adenylsucc_synt
SM00788	$\"[3-422]T$	Adenylsucc_synt
TIGR00184	$\"[5-428]T$	purA
PS00513	$\"[131-142]T$	ADENYLOSUCCIN_SYN_2
PS01266	$\"[10-17]T$	ADENYLOSUCCIN_SYN_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.440.10	$\"[4-264]T$	G3DSA:3.40.440.10
G3DSA:3.90.170.10	$\"[265-429]T$	G3DSA:3.90.170.10
SSF52540	$\"[1-423]T$	SSF52540

","BeTs to 12 clades of COG0104COG name: Adenylosuccinate synthaseFunctional Class: FThe phylogenetic pattern of COG0104 is amtkyqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001114 (Adenylosuccinate synthetase) with a combined E-value of 6.9e-161. IPB001114A 17-54 IPB001114B 95-115 IPB001114C 125-150 IPB001114D 217-255 IPB001114E 261-280 IPB001114F 293-334 IPB001114G 370-402","Residues 393-429 are 86% similar to a (LIGASE AMPSASE ADSS GTP-BINDING) protein domain (PD372337) which is seen in PURA_LACLA.Residues 1-142 are 38% similar to a (LIGASE AMPSASE ADSS GTP-BINDING) protein domain (PD176155) which is seen in PURA_METJA.Residues 393-427 are 62% similar to a (LIGASE AMPSASE ADSS GTP-BINDING) protein domain (PD164474) which is seen in PURA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:30:16 2007","Wed Jan 9 11:48:25 2002","Fri Mar 16 11:30:16 2007","Thu Mar 28 13:31:15 2002","Wed Jan 9 11:48:25 2002","Wed Jan 9 11:48:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0243 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 13:31:15 2002","Fri Mar 16 11:30:16 2007","pdb1ADEA Chain A, Structure Of Adenylosuccinate Synthetase Ph... 421 6e-119pdb1CG1A Chain A, Structure Of The Mutant (K16q) Of Adenylosu... 420 2e-118pdb1CG4A Chain A, Structure Of The Mutant (R303l) Of Adenylos... 419 4e-118","SMU.268","","Residues 3 to 422 (E-value = 1.3e-278) place SMu0243 in the Adenylsucc_synt family which is described as Adenylosuccinate synthetase (PF00709)","Wed Jan 9 11:48:25 2002","24378775","","","","","","1","","7","SMU.268","185" "SMu0244","261355","262812","1458","ATGAATATTCTTATTAATATTCTAACTTGGTTCTCGCAAAATATTTTGCAAAAACCGGCCTTTTTTGTAGGTATCTTAGTATTAATTGGATACTTGCTCCTCAAAAAACCATTACACGATGTATTTGCTGGTTTCATTAAGGCAACTGTTGGATATATGATTCTGGATGTTGGTGCTGGCGGTCTAGTGACAACCTTTCGTCCCATTTTAGCAGCACTTAATTATAAATTCAAAATTGGTGCGGCGGTTATTGACCCATATTTTGGGCTGACAGCAGCAAATGAAAAGATTGCTCAAGAGTTCCCTAGATTTATTGGTACAGCAACAACAGCGCTCTTGATTGGCTTCTTCTTCAATATTCTTCTGGTTGCCCTTCGTAAGATTACTAAGATTCGTACCTTGTTCATTACAGGTCACATCATGGTACAACAAGCTGCGACAGTTACCTTGATGGTTATCCTTTTAATTCCAGCTTTTCGCAATCAGTTCTGGGGAACTTTAGCTGTAGGGATCATCTGTGGTCTTTATTGGGCGGTTAGTTCTAATATGACTGTTGAGCCAACACAGCGCTTAACTGGCGGCGGTGGTTTTGCTATCGGACACCAACAGCAATTTGCTATTTGGTTTACAGATAAGATTGCTCCAAAACTTGGTAAAAAAGAAGAAAATTTGGACAACTTGAAATTGCCAGCTTTCTTAAATATCTTCCATGATACAGTTGTTGCCTCAGCAACCTTGATGCTCGTCTTCTTTGGTGCTATCTTGGCTATCCTTGGTCCGGATATCATGTCTAATCCAAAGGTGATTACAACGGGTACCTTGTTTGATCCAACCAAACAAGCCTTCTTTATGTACGTTGTTCAAACGGCCTTTACTTTTTCTGTTTATCTTTTTGTCTTGATGCAAGGTGTGCGGATGTTTGTCGGTGAACTGACCAATGCCTTCCAAGGTATCTCTAACAAACTTCTCCCTGGTTCTTTCCCAGCAGTTGACGTTGCGGCGTCCTATGGTTTTGGATCACCTAGTGCAGTCCTCTTTGGTTTTGCAACTGGACTTATTGGACAGTTAATTACAATCGTGTTATTGATTGTCTTTAAGAATCCAGTCTTGATTATCACAGGTTTCGTTCCAGTATTCTTTGATAATGCTGCGATTGCTGTTTATGCCGACAAACGCGGAGGTTGGAAAGCAGCAGTTGTTCTGTCATTCTTATCAGGTGTGCTTCAAGTGGCACTTGGTGCAGTTGCAGTTGCTCTTCTAGGTCTGGCAGGATTTGGCGGTTATCATGGTAACATTGACTTTGAAATTCCATGGGTGCCATTTGCTTATCTTTTCAAATATGCAGGAGTTATCGGTTATGCTCTTGTGGCAGTCTTCTTACTTGCTATCCCGCAAATTCAATTTGCTAAAGCAAAAGATAAGGAAGCCTACTATCGTGGAGATGCTCAAGCAGAATAA","10.30","11.15","52590","MNILINILTWFSQNILQKPAFFVGILVLIGYLLLKKPLHDVFAGFIKATVGYMILDVGAGGLVTTFRPILAALNYKFKIGAAVIDPYFGLTAANEKIAQEFPRFIGTATTALLIGFFFNILLVALRKITKIRTLFITGHIMVQQAATVTLMVILLIPAFRNQFWGTLAVGIICGLYWAVSSNMTVEPTQRLTGGGGFAIGHQQQFAIWFTDKIAPKLGKKEENLDNLKLPAFLNIFHDTVVASATLMLVFFGAILAILGPDIMSNPKVITTGTLFDPTKQAFFMYVVQTAFTFSVYLFVLMQGVRMFVGELTNAFQGISNKLLPGSFPAVDVAASYGFGSPSAVLFGFATGLIGQLITIVLLIVFKNPVLIITGFVPVFFDNAAIAVYADKRGGWKAAVVLSFLSGVLQVALGAVAVALLGLAGFGGYHGNIDFEIPWVPFAYLFKYAGVIGYALVAVFLLAIPQIQFAKAKDKEAYYRGDAQAE","262809","For other 'rmp' genes see SMu0245 (rmpB); SMu0246 (rmpA); SMu0247 (rmpD); SMu0248 (rmpE) and SMu0249 (rmpF).","ribulose monophosphate PTS pathway enzyme IIC","Membrane, Cytoplasm","This sequence corresponds to the previously sequenced g15625421 in GenBank, a predicted RmpC protein. Furthermore, residues 1-485 are 75% similar to gi|15903891 from S.pneumoniae, a predicted Phosphotransferase system sugar-specific EII component.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1815 (0.0).","

InterPro
IPR007333
Family

Putative sugar-specific permease, SgaT/UlaA
PF04215	$\"[5-437]T$	SgaT_UlaA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 41-399 are 43% similar to a (PROTEOME COMPLETE TRANSPORT MEMBRANE) protein domain (PD043062) which is seen in SGAT_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 16:09:19 2002","Sun Jan 13 14:06:40 2002","Thu Oct 24 16:09:19 2002","Sun Jan 13 14:04:16 2002","","Sun Jan 13 14:04:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0244 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 13 14:06:40 2002","","No significant hits to the NCBI PDB database.","SMU.270","","Residues 5 to 437 (E-value = 4.6e-225) place SMu0244 in the SgaT_UlaA family which is described as Putative sugar-specific permease, SgaT/UlaA (PF04215)","Sun Jan 13 14:04:16 2002","24378776","","","Mitsui R, Sakai Y, Yasueda H, Kato N.A novel operon encoding formaldehyde fixation: the ribulose monophosphate pathway in the gram-positive facultativemethylotrophic bacterium Mycobacterium gastri MB19.J Bacteriol. 2000 Feb;182(4):944-8.PMID: 10648518","Sun Jan 13 14:06:40 2002","Sun Jan 13 14:38:11 2002","1","","7","SMU.270","" "SMu0245","262880","263161","282","ATGGTTAAAGTTCTTACAGCATGCGGAAATGGCATGGGCTCATCAATGGTTATTAAAATGAAGGTTGAAAATGCTTTGCGTCAATTAGGTGTATCGGATATTGAATCAGCATCATGTTCAGTTGGCGAAGCCAAAGGTTTAGCTTCAAATTATGATATTGTTGTCGCTTCGAACCACCTCATTCATGAATTGGACGGCCGTACGAATGGTAAATTAATTGGTCTTGATAATTTAATGGATGATAATGAAATTAAGACAAAATTGGAAGAAGCATTGAAATAA","5.20","-2.63","9888","MVKVLTACGNGMGSSMVIKMKVENALRQLGVSDIESASCSVGEAKGLASNYDIVVASNHLIHELDGRTNGKLIGLDNLMDDNEIKTKLEEALK","263158","For other 'rmp' genes see SMu0244 (rmpC); SMu0246 (rmpA); SMu0247 (rmpD); SMu0248 (rmpE) and SMu0249 (rmpF).For other 'ptx' genes see SMu0246 (ptxA).","PTS system, enzyme IIB component","Cytoplasm","This sequence corresponds to the previously sequenced g15625422 in GenBank, a predicted RmpB protein. Furthermore, residues 1-92 are 91% similar to gi|15674380 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1814 (2e-44).","

InterPro
IPR003501
Domain

Phosphotransferase system, lactose/cellobiose-specific IIB subunit
PF02302	$\"[3-93]T$	PTS_IIB

InterPro
IPR013011
Domain

Phosphotransferase system, EIIB component, type 2
PS51099	$\"[2-93]T$	PTS_EIIB_TYPE_2

noIPR
unintegrated

unintegrated
SSF52794	$\"[1-93]T$	SSF52794

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-92 are 42% similar to a (PHOSPHOTRANSFERASE B PROTEOME COMPONENT) protein domain (PD353090) which is seen in PTXB_MYCPN.Residues 2-93 are 40% similar to a (PHOSPHOTRANSFERASE PROTEOME COMPLETE B) protein domain (PD068164) which is seen in PTXB_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 16:08:48 2002","Sun Jan 13 14:12:08 2002","Thu Oct 24 16:08:48 2002","Sun Jan 13 14:12:08 2002","","Sun Jan 13 14:12:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0245 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 13 14:13:34 2002","","No significant hits to the NCBI PDB database.","SMU.271","","Residues 3 to 93 (E-value = 1.1e-34) place SMu0245 in the PTS_IIB family which is described as PTS system, Lactose/Cellobiose specific IIB subunit (PF02302)","Sun Jan 13 14:12:08 2002","24378777","","","Mitsui R, Sakai Y, Yasueda H, Kato N.A novel operon encoding formaldehyde fixation: the ribulose monophosphate pathway in the gram-positive facultativemethylotrophic bacterium Mycobacterium gastri MB19.J Bacteriol. 2000 Feb;182(4):944-8.PMID: 10648518","Sun Jan 13 14:13:34 2002","Sun Jan 13 14:38:41 2002","1","","7","SMU.271","" "SMu0246","263227","263712","486","ATGAACTTAGCACAAGCCTTTAAAGAAAATCATTCAATCCGATTAGGGTTAACAGCCAAAGATTGGAAAGAAGCTGTTAAACTGTCTGTCACCCCTCTTATTGAAAGCGGTGCAGTAAAACCTGAATACTATAATGCTATTATTGAGTCAACTGAAAGTTATGGACCTTATTATATCTTAATGCCGGGTATGGCTATGCCTCATGCTCGTCCAGAAGCAGGCGTGCAGCGCGATGCCTTTTCATTAGTGACATTGACAGAGCCCGTTACCTTTACAGATGGCAAAGAAGTTCAAGTTCTCCTTGCTCTTGCAGCGACTAGTTCAAAAATTCATACATCAGTAGCTATTCCCCAAATCATTGCACTTTTTGAATTAGATCATTCCATTGAACGCCTTGTTAATTGCAAAACGCCAGAAGAAGTGCTTGCTATGGTAGAAGAATCTAAAAGCAGTCCCTATCTTGAGGGGCTTGACCTTGATTCATGA","4.70","-8.08","17664","MNLAQAFKENHSIRLGLTAKDWKEAVKLSVTPLIESGAVKPEYYNAIIESTESYGPYYILMPGMAMPHARPEAGVQRDAFSLVTLTEPVTFTDGKEVQVLLALAATSSKIHTSVAIPQIIALFELDHSIERLVNCKTPEEVLAMVEESKSSPYLEGLDLDS","263709","For other 'rmp' genes see SMu0244 (rmpC); SMu0245 (rmpB); SMu0247 (rmpD); SMu0248 (rmpE) and SMu0249 (rmpF).For other 'ptx' genes see SMu0245 (ptxB).","PTS system, enzyme IIA component","Cytoplasm","This sequence corresponds to the previously sequenced g15625423 in Genbank, a predicted ribulose monophosphate PTS pathway enzyme IIA. Additionally, residues 1-161 are 70% similar to gi|15674381 in S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1813 (1e-70).","

InterPro
IPR002178
Domain

Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PD001689	$\"[8-140]T$	PTS_EIIA_2
G3DSA:3.40.930.10	$\"[9-149]T$	PTS_EIIA_2
PF00359	$\"[6-148]T$	PTS_EIIA_2
PS51094	$\"[6-148]T$	PTS_EIIA_TYPE_2

noIPR
unintegrated

unintegrated
SSF55804	$\"[5-147]T$	SSF55804

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 13-145 are 44% similar to a (PHOSPHOTRANSFERASE SYSTEM ENZYME) protein domain (PD202753) which is seen in PTXA_MYCPN.Residues 13-142 are 45% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIA ENZYME COMPLETE) protein domain (PD001689) which is seen in PTXA_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:32:41 2002","Sun Jan 13 14:27:08 2002","Sun Jan 13 14:31:41 2002","Sun Jan 13 14:27:08 2002","","Sun Jan 13 14:27:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0246 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 13 14:29:44 2002","","No significant hits to the NCBI PDB database.","SMU.272","","Residues 6 to 148 (E-value = 2.1e-39) place SMu0246 in the PTS_EIIA_2 family which is described as Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PF00359)","Sun Jan 13 14:27:08 2002","24378778","","","Mitsui R, Sakai Y, Yasueda H, Kato N.A novel operon encoding formaldehyde fixation: the ribulose monophosphate pathway in the gram-positive facultativemethylotrophic bacterium Mycobacterium gastri MB19.J Bacteriol. 2000 Feb;182(4):944-8.PMID: 10648518","Sun Jan 13 14:29:44 2002","Sun Jan 13 14:39:12 2002","1","","7","SMU.272","" "SMu0247","263751","264416","666","ATGACAAAACAATTGCCAAATTTACAGGTTGCACTGGACCATTCTAACTTGAAAGGCGCTATTACAGCAGCGGTTTCTGTAGGAAATGAAGTAGATGTTATAGAAGCAGGAACTGTCTGTCTCCTTCAAGTTGGCAGCGAATTGGTAGAAGTCTTACGCAGTCTTTTTCCAGATAAAATCATCGTTGCCGATACAAAGTGTGCTGATGCTGGCGGTACAGTTGCTAAAAATAATGCTGTGCGTGGCGCTGACTGGATGACCTGTATCTGTTCAGCTACTATTCCAACCATGAAAGCAGCCCGTAAAGCTATTGAAGACATTAATCCTGATAAAGGTGAGATTCAGGTTGAGCTCTATGGTGATTGGACCTATGATCAGGCTCAACAGTGGTTAGATGCCGGTATTTCACAAGCGATCTATCACCAATCACGCGATGCTCTGCTTGCAGGTGAAACTTGGGGAGAAAAAGACCTTAACAAGGTTAAAAAACTTATTGAAATGGGTTTTCGTGTTTCAGTAACCGGTGGTCTTAGTGTTGACACCTTGAAACTCTTTGAAGGAGTTGATGTTTTCACCTTTATCGCAGGACGTGGGATCACTGAGGCGAAAAATCCTGCTGGGGCAGCACGTGCATTTAAAGACGAAATCAAACGGATCTGGGGGTAG","5.00","-4.70","23809","MTKQLPNLQVALDHSNLKGAITAAVSVGNEVDVIEAGTVCLLQVGSELVEVLRSLFPDKIIVADTKCADAGGTVAKNNAVRGADWMTCICSATIPTMKAARKAIEDINPDKGEIQVELYGDWTYDQAQQWLDAGISQAIYHQSRDALLAGETWGEKDLNKVKKLIEMGFRVSVTGGLSVDTLKLFEGVDVFTFIAGRGITEAKNPAGAARAFKDEIKRIWG","264413","For other 'rmp' genes see SMu0244 (rmpC); SMu0245 (rmpB); SMu0246 (rmpA); SMu0248 (rmpE) and SMu0249 (rmpF).","hexulose-6-phosphate synthase","Cytoplasm","This sequence corresponds to the previously sequenced g15625424 in GenBank, a predicted rmpD protein. Furthermore, residues 1-221 are 88% similar to gi|15903888 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1812 (1e-113).","

InterPro
IPR001754
Domain

Orotidine 5'-phosphate decarboxylase, core
PF00215	$\"[6-212]T$	OMPdecase

InterPro
IPR011060
Domain

Ribulose-phosphate binding barrel
SSF51366	$\"[5-220]T$	RibP_bind_barrel

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[3-221]T$	Aldolase_TIM

","BeTs to 6 clades of COG0269COG name: 3-hexulose-6-phosphate synthase and related proteinsFunctional Class: GThe phylogenetic pattern of COG0269 is Amtk----Eb-h---p-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 111-220 are 44% similar to a (LYASE PROTEOME HUMPS HEXULOSE-6-PHOSPHATE) protein domain (PD016483) which is seen in Q9CMP9_PASMU.Residues 8-216 are 46% similar to a (DECARBOXYLASE LYASE SYNTHASE PYRIMIDINE BIOSYNTHESIS) protein domain (PD001042) which is seen in SGAH_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:33:39 2002","Sun Jan 13 14:32:29 2002","Sun Jan 13 14:37:37 2002","Tue Apr 9 14:08:52 2002","","Sun Jan 13 14:32:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0247 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 13 14:34:08 2002","","No significant hits to the NCBI PDB database.","SMU.273","","Residues 6 to 212 (E-value = 1.3e-52) place SMu0247 in the OMPdecase family which is described as Orotidine 5'-phosphate decarboxylase / HUMPS family (PF00215)","Sun Jan 13 14:32:29 2002","24378779","","","Mitsui R, Sakai Y, Yasueda H, Kato N.A novel operon encoding formaldehyde fixation: the ribulose monophosphate pathway in the gram-positive facultativemethylotrophic bacterium Mycobacterium gastri MB19.J Bacteriol. 2000 Feb;182(4):944-8.PMID: 10648518Yasueda H, Kawahara Y, Sugimoto S.Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, andyckH is required for their expression.J Bacteriol. 1999 Dec;181(23):7154-60.PMID: 10572115","Sun Jan 13 14:34:08 2002","Sun Jan 13 14:43:04 2002","1","","7","SMU.273","" "SMu0248","264422","265285","864","ATGGCACGTCCAATTGGTATTTATGAAAAGGCAACACCTAAACACTTTACTTGGTTGGAACGCCTCAACTTTGCCAAGGAACTTGGTTTTGATTTTGTCGAGTTGTCCATTGATGAGAGCGACGAACGTTTGGCACGTTTGGATTGGTCCAAGAAAGAACGTCTAGAATTGGTTAACGCTATTTTTGAGACAGGTGTGCGGATTCCCACCATTACTTTTAGCGGACATCGCCGTTATCCACTGGGATCCAACGATTCTGAAAAAGAAGCGCGTGCTCTTGAAATGATGGAAAAATGTATCGAGTTTGCACAGGACATTGGTATTCGTAATATCCAGCTGGCTGGCTACGATGTTTACTACGAAGAGAAGTCTCCTAAAACACGTGCACGCTTCCTTAAAAATTTACGTCAGGCCTGTACTTGGGCTGAAGAAGCGCAAGTTATCTTATCAATTGAAATCATGGATGATCCTTTCATCAATTCGATTGAAAAATATCTAGCTGTCGAAAAAGAAATTGACTCTCCTTACCTCTTTGTTTATCCTGATGCAGGAAATGTCTCAGCTTGGGGCAATGATCTTTGGAGTGAATTCTACATTGGGCACAAATCTATCGCAGCCCTTCACTTAAAAGATACTTATGCCGTCACAGAAAGTTCAAAAGGTCAATTTCGTGATGTGCCATTTGGTCAGGGCTGTGTAGATTGGGAAGCCATGTTTGATGTTTTGAAGAAAACAAATTATAATGGCCCATTTTTAATTGAAATGTGGTCTGAAAATTGTGAAACGGTAGAAGAAACGCGTGCAGCCATTAAAGAAGCACAAGATTTCCTCTATCCTTTAATTGAGAAAGCGGGGTTACGCTAA","4.70","-13.19","33161","MARPIGIYEKATPKHFTWLERLNFAKELGFDFVELSIDESDERLARLDWSKKERLELVNAIFETGVRIPTITFSGHRRYPLGSNDSEKEARALEMMEKCIEFAQDIGIRNIQLAGYDVYYEEKSPKTRARFLKNLRQACTWAEEAQVILSIEIMDDPFINSIEKYLAVEKEIDSPYLFVYPDAGNVSAWGNDLWSEFYIGHKSIAALHLKDTYAVTESSKGQFRDVPFGQGCVDWEAMFDVLKKTNYNGPFLIEMWSENCETVEETRAAIKEAQDFLYPLIEKAGLR","265282","For other 'rmp' genes see SMu0244 (rmpC); SMu0245 (rmpB); SMu0246 (rmpA); SMu0247 (rmpD) and SMu0249 (rmpF).","hexulose-6-phosphate isomerase","Cytoplasm","This sequence corresponds to the previously sequenced gi|15625425 in GenBank, a predicted RmpE protein. Additionally, residues 1-286 are 83% similar to gi|15903887 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1811 (1e-155).","

InterPro
IPR004560
Family

Putative hexulose-6-phosphate isomerase
TIGR00542	$\"[1-287]T$	hxl6Piso_put

InterPro
IPR012307
Domain

Xylose isomerase-like TIM barrel
PF01261	$\"[22-233]T$	AP_endonuc_2

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.150	$\"[3-276]T$	G3DSA:3.20.20.150
PTHR12110	$\"[1-281]T$	PTHR12110
SSF51658	$\"[1-284]T$	SSF51658

","BeTs to 4 clades of COG1082COG name: Predicted endonucleasesFunctional Class: LThe phylogenetic pattern of COG1082 is AMTk--VCEBrH---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 5-286 are 52% similar to a (ISOMERASE HEXULOSE-6-PHOSPHATE HUMPI) protein domain (PD017663) which is seen in SGBU_HAEIN.Residues 14-277 are 20% similar to a (PROTEOME IOLH COMPLETE MYO-INOSITOL) protein domain (PD127492) which is seen in Q9KAH7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:34:05 2002","Sun Jan 13 14:59:35 2002","Sun Jan 13 15:04:07 2002","Tue Apr 9 14:09:39 2002","","Sun Jan 13 14:59:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0248 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 13 15:01:19 2002","","No significant hits to the NCBI PDB database.","SMU.274","","Residues 1 to 287 (E-value = 2.8e-201) place SMu0248 in the Hxl6Piso_put family which is described as Putative hexulose-6-phosphate isomerase (PF03809)Residues 5 to 233 (E-value = 4.4e-05) place SMu0248 in the AP_endonuc_2 family which is described as AP endonuclease family 2 (PF01261)","Sun Jan 13 14:59:35 2002","24378780","","","","Sun Jan 13 15:01:19 2002","","1","","7","SMU.274","" "SMu0249","265288","265998","711","ATGTTAGTACCTGAACTGCGCGAACGCGTCTACAAAGCTAATATGGAACTGCCAGAACATGGTCTGGTTAAGTTTACTTGGGGAAATGTCTCAGCTATTGACCGCGAAGGTGGCTATATTGCCATTAAACCATCTGGAGTTGCTTATGACAAATTATCGGCGGAAAATATGGTCATTACAGATCTTGATGGAAATATCCTTGAAGGAGACTTGAATCCTTCATCAGATTTGCCAACGCATGTCGAATTGTACAAAGCTTTCCCGGAAGTTGGCGGTATTGTCCATACACACTCAACGGAAGGCGTGTCTTGGGCACAGGCCGGCCGTGATATTCCTTGTTACGGAACAACACATGCAGATACCTTCTACGGGGCAATTCCATGTGCGCGTGCTTTGACGCCGAAAGAAATCAATGGTGAATATGAAAAAGAAACCGGAAAAGTTATCATTGAAGAATTTAAAAAACGCGGTCTTGACCCTTTAGCTGTTTCTGGTGTCACTGTCCGCAATCACGGACCATTTGCTTGGGGAAAAGACGAAAAGTCAGCTGTATACAATGCAGTTGTCTTGGAAGAAGCAGCTCGCATGGCGAGATATACAGAAAGTATCAATCCAGAAGTGGAAGAGGTACCGCAAGCACTCAAAGATAAACATTATCTCCGTAAGCATGGTAAGAATGCTTACTATGGACAAAAAGGCGATAGTCATTAA","5.90","-5.91","26072","MLVPELRERVYKANMELPEHGLVKFTWGNVSAIDREGGYIAIKPSGVAYDKLSAENMVITDLDGNILEGDLNPSSDLPTHVELYKAFPEVGGIVHTHSTEGVSWAQAGRDIPCYGTTHADTFYGAIPCARALTPKEINGEYEKETGKVIIEEFKKRGLDPLAVSGVTVRNHGPFAWGKDEKSAVYNAVVLEEAARMARYTESINPEVEEVPQALKDKHYLRKHGKNAYYGQKGDSH","265995","For other 'rmp' genes see SMu0244 (rmpC); SMu0245 (rmpB); SMu0246 (rmpA); SMu0247 (rmpD) and SMu0248 (rmpE).","L-ribulose 5-phosphate 4-epimerase","Cytoplasm","This sequence corresponds to the previously sequenced gi|15625426 in GenBank, a predicted RmpF protein. In addition, residues 5-232 are 74% similar to gi|15674384 in S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1810 (1e-103).","

InterPro
IPR001303
Domain

Class II aldolase/adducin, N-terminal
G3DSA:3.40.225.10	$\"[2-231]T$	Aldolase_II/adducin_N
PF00596	$\"[8-218]T$	Aldolase_II
SSF53639	$\"[2-223]T$	Aldolase_II_N

noIPR
unintegrated

unintegrated
PTHR22789	$\"[78-231]T$	PTHR22789

","BeTs to 11 clades of COG0235COG name: Ribulose-5-phosphate 4-epimerase and related epimerases and aldolasesFunctional Class: GThe phylogenetic pattern of COG0235 is amtkyQV-EBrHuj-p----xNumber of proteins in this genome belonging to this COG is 1","***** IPB001303 (Class II Aldolase and Adducin N-terminal domain) with a combined E-value of 2e-34. IPB001303A 23-32 IPB001303B 36-61 IPB001303C 80-98 IPB001303D 166-183","Residues 26-112 are 67% similar to a (ADDUCIN PROTEOME COMPLETE ALDOLASE ISOMERASE MEMBRANE) protein domain (PD001906) which is seen in Q9KMS6_VIBCH.Residues 115-231 are 62% similar to a (ISOMERASE 4-EPIMERASE ZINC SUGAR 5.1.-.-) protein domain (PD317741) which is seen in Q9CLI6_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:35:07 2002","Sun Jan 13 15:05:36 2002","Sun Jan 13 15:13:46 2002","Tue Apr 9 14:10:05 2002","Sun Jan 13 15:05:36 2002","Sun Jan 13 15:05:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0249 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 13 15:09:35 2002","Sun Jan 13 15:05:36 2002","pdb|1DZZ|P Chain P, L-Fuculose-1-Phosphate Aldolase From Escher... 62 5e-011pdb|1DZW|P Chain P, L-Fuculose-1-Phosphate Aldolase From Escher... 62 5e-011pdb|1DZV|P Chain P, L-Fuculose-1-Phosphate Aldolase From Escher... 62 5e-011","SMU.275","","Residues 8 to 218 (E-value = 1.1e-94) place SMu0249 in the Aldolase_II family which is described as Class II Aldolase and Adducin N-terminal domain (PF00596)","Sun Jan 13 15:05:36 2002","24378781","","","Lee LV, Poyner RR, Vu MV, Cleland WW.Role of metal ions in the reaction catalyzed by L-ribulose-5-phosphate 4-epimerase.Biochemistry. 2000 Apr 25;39(16):4821-30.PMID: 10769139Lee LV, Vu MV, Cleland WW.13C and deuterium isotope effects suggest an aldol cleavage mechanism for L-ribulose-5-phosphate 4-epimerase.Biochemistry. 2000 Apr 25;39(16):4808-20.PMID: 10769138","Sun Jan 13 15:09:35 2002","Sun Jan 13 15:13:46 2002","1","","7","SMU.275","" "SMu0250","266341","266180","162","ATGACAGGTGCAATAATATTTCAAAATTTTAATATCTGTGACATCTGGTTGAAAAGTATAGGAAATTTTTCTGTTAAATTAGATAAATTAGAATTGCTTAATAGTGACCGTTGTTTTTGTAAAATCTTGACTAACATTGACAAGAGGGGCTTTTTTATATAA","8.40","1.83","6141","MTGAIIFQNFNICDIWLKSIGNFSVKLDKLELLNSDRCFCKILTNIDKRGFFI","266183","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST.SMu0250 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 18:35:38 2002","Sun Jan 13 15:15:06 2002","Wed Oct 9 18:35:38 2002","Sun Jan 13 15:15:06 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0250 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 18:35:38 2002","","No significant hits to the NCBI PDB database.","SMU.276c","","No significant hits to the Pfam 11.0 database","Sun Jan 13 15:15:06 2002","24378782","","","","","","1","","7","SMU.276c","" "SMu0251","266412","266663","252","ATGGCATTTGATCATTTTGAAACAGCAGGAGAAGATTACCTTACTGAAATCGAAGGAGAAGGACTAGGTCTTGGTATCTGTCTTGGGCTTGTTGGTTTTGCAGGTGGTTTTGCCCATGGAGTTGTCCAAGGAGCTGGAGTAGGAACTGCAATAGAGCCTGGATATGGTACAATAATTGGTGCCTTAGTTGATGGAGTTGGCCAAGATCTTATATATGGAGGAGCTGGTTTTGCAGCTGGTTATAGTCTATGA","3.60","-9.58","8123","MAFDHFETAGEDYLTEIEGEGLGLGICLGLVGFAGGFAHGVVQGAGVGTAIEPGYGTIIGALVDGVGQDLIYGGAGFAAGYSL","266660","","hypothetical protein","Extracellular","No significant hits in gapped BLAST.SMu0251 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[21-39]?$ $\"[45-63]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-34]?$	signal-peptide
tmhmm	$\"[21-41]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[34-54]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[29-49]?$ $\"[64-82]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[51-71]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-25]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[34-52]?$ $\"[84-104]?$ $\"[108-128]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[9-27]?$ $\"[33-53]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Jan 13 15:34:17 2002","Sun Jan 13 15:34:17 2002","Sun Jan 13 15:34:17 2002","Sun Jan 13 15:34:17 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0257 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 13 15:34:17 2002","","No significant hits to the NCBI PDB database.","SMU.285","","No significant hits to the Pfam 11.0 database","Sun Jan 13 15:34:17 2002","24378789","","","","","","1","","","SMU.285","" "SMu0258","270628","272910","2283","ATGAAACAAGTTATTTATGTTGTTTTAATCGTCATAGCCGTTAACATTCTCTTAGAGATTATCAAAAGAGTAACAAAAAGGGGAGGGACAGTTTCGTCATCTAATCCTTTACCAGATGGGCAGTCTAAGTTGTTTTGGCGCAGACATTATAAGCTAGTACCTCAGATTGATACCAGAGACTGTGGGCCGGCAGTGCTGGCATCTGTTGCAAAGCATTACGGATCTAATTACTCTATCGCTTATCTGCGGGAACTCTCAAAGACTAACAAGCAGGGAACAACAGCTCTTGGCATTGTTGAAGCTGCTAAAAAGTTAGGCTTTGAAACACGCTCTATCAAGGCGGATATGACGCTTTTTGATTATAATGATTTGACCTATCCTTTTATCGTCCATGTGATTAAAGGAAAACGTCTGCAGCATTATTATGTCGTCTATGGCAGCCAGAATAATCAGCTGATTATTGGAGATCCTGATCCTTCAGTTAAGGTGACTAGGATGAGTAAGGAACGCTTTCAATCAGAGTGGACAGGCCTTGCAATTTTCCTAGCTCCTCAGCCTAACTATAAGCCTCATAAAGGTGAAAAAAATGGTTTGTCTAATTTCTTCCCGTTGATCTTTAAGCAGAAAGCTTTGATGACTTATATTATCATAGCTAGCTTGATTGTGACGCTCATTGATATTGTCGGATCATACTATCTCCAAGGAATATTGGACGAGTACATTCCTGATCAGCTGATTTCAACTTTAGGAATGATTACGATTGGTCTGATAATAACCTATATTATCCAGCAGGTCATGGCTTTTGCAAAAGAATACCTCTTGGCCGTACTCAGTTTGCGTTTAGTCATTGATGTTATCCTGTCTTATATCAAACATATTTTTACGCTTCCTATGTCTTTCTTTGCGACAAGGCGAACAGGAGAAATCACGTCTCGTTTTACAGATGCCAATCAGATTATTGATGCTGTAGCGTCAACCATCTTTTCAATCTTTTTAGATATGACTATGGTAATTTTGGTTGGTGGGGTTTTGTTGGCGCAAAACAATAACCTTTTCTTTCTAACCTTGCTCTCCATTCCGATTTATGCCATCATTATTTTTGCTTTCTTGAAACCCTTTGAGAAAATGAATCACGAAGTGATGGAAAGCAATGCTGTGGTAAGTTCTTCTATCATTGAAGATATCAATGGGATGGAAACCATTAAATCACTCACAAGTGAGTCCGCTCGTTATCAAAACATTGATAGTGAATTTGTTGATTATTTGGAGAAAAACTTTAAGCTACACAAGTATAGTGCCATTCAAACCGCATTAAAAAGCGGTGCTAAGCTTATCCTCAATGTTGTCATTCTCTGGTATGGCTCTCGTCTAGTTATGGATAATAAAATCTCAGTTGGTCAGCTTATCACCTTTAATGCTTTGCTGTCTTATTTCTCAAATCCAATTGAAAATATTATCAATCTGCAATCCAAACTGCAGTCAGCTCGCGTTGCCAATACACGTCTTAATGAGGTCTATCTTGTCGAATCTGAATTTGAAAAAGACGGCGATTTATCAGAAAATAGCTTTTTAGATGGTGATATTTCGTTTGAAAATCTTTCTTATAAATATGGATTTGGGCGAGATACCTTATCAGATATTAATTTATCAATCAAAAAAGGCTCCAAGGTCAGTCTAGTTGGAGCCAGTGGTTCTGGTAAAACAACTTTGGCTAAACTGATTGTCAATTTCTACGAGCCTAACAAGGGGATTGTTCGAATCAATGGCAATGATTTAAAAGTTATTGATAAGACAGCTTTGCGGCGGCATATTAGCTATTTGCCGCAACAGGCCTATGTTTTTAGTGGCTCTATTATGGATAATCTCGTTTTAGGAGCTAAAGAAGGAACGAGTCAGGAAGACATTATTCGTGCTTGTGAAATTGCTGAAATCCGCTCGGACATTGAACAAATGCCTCAGGGCTATCAGACAGAGTTATCAGATGGTGCCGGTATTTCTGGCGGTCAAAAACAGCGGATTGCTTTAGCTAGGGCCTTATTAACACAGGCACCGGTTTTGATTCTGGATGAAGCCACCAGCAGTCTTGATATTTTGACAGAAAAGAAAATTATCAGCAATCTCTTACAGATGACGGAGAAAACAATAATTTTTGTTGCCCACCGCTTAAGCATTTCACAGCGTACTGACGAAGTCATTGTCATGGATCAGGGAAAAATTGTTGAACAAGGCACTCATAAGGAACTTTTAGCTAAGCAAGGTTTCTATTATAACCTGTTTAATTGA","9.30","7.60","85091","MKQVIYVVLIVIAVNILLEIIKRVTKRGGTVSSSNPLPDGQSKLFWRRHYKLVPQIDTRDCGPAVLASVAKHYGSNYSIAYLRELSKTNKQGTTALGIVEAAKKLGFETRSIKADMTLFDYNDLTYPFIVHVIKGKRLQHYYVVYGSQNNQLIIGDPDPSVKVTRMSKERFQSEWTGLAIFLAPQPNYKPHKGEKNGLSNFFPLIFKQKALMTYIIIASLIVTLIDIVGSYYLQGILDEYIPDQLISTLGMITIGLIITYIIQQVMAFAKEYLLAVLSLRLVIDVILSYIKHIFTLPMSFFATRRTGEITSRFTDANQIIDAVASTIFSIFLDMTMVILVGGVLLAQNNNLFFLTLLSIPIYAIIIFAFLKPFEKMNHEVMESNAVVSSSIIEDINGMETIKSLTSESARYQNIDSEFVDYLEKNFKLHKYSAIQTALKSGAKLILNVVILWYGSRLVMDNKISVGQLITFNALLSYFSNPIENIINLQSKLQSARVANTRLNEVYLVESEFEKDGDLSENSFLDGDISFENLSYKYGFGRDTLSDINLSIKKGSKVSLVGASGSGKTTLAKLIVNFYEPNKGIVRINGNDLKVIDKTALRRHISYLPQQAYVFSGSIMDNLVLGAKEGTSQEDIIRACEIAEIRSDIEQMPQGYQTELSDGAGISGGQKQRIALARALLTQAPVLILDEATSSLDILTEKKIISNLLQMTEKTIIFVAHRLSISQRTDEVIVMDQGKIVEQGTHKELLAKQGFYYNLFN","272907","For other components see SMu0259 (SBP1). For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).","competence factor transporting ATP-binding/permease protein","Membrane, Cytoplasm, Extracellular","Residues 45-760 are 63% similar in gapped BLAST to gi15902087, a predicted ComA protein from S.pneumoniae.Residues 267-723 are 24% similar to residues 47-518 of gi5918764, a predicted MutT protein previously published in GenBank. See also gi4103630, gi9802002, gi15625436, gi2062756, gi2492598, gi2952525, gi9802355 and others which don't quite correspond to genomic sequences.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (2e-61).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[206-482]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[666-707]T$	ABC_transporter
PF00005	$\"[554-737]T$	ABC_tran
PS00211	$\"[665-679]T$	ABC_TRANSPORTER_1
PS50893	$\"[528-760]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[553-738]T$	AAA

InterPro
IPR005074
Domain

Peptidase C39, bacteriocin processing
PF03412	$\"[53-187]T$	Peptidase_C39
PS50990	$\"[55-182]T$	PEPTIDASE_C39

InterPro
IPR005897
Family

Peptidase C39, ABC-type bacteriocin transporter
TIGR01193	$\"[55-760]T$	bacteriocin_ABC

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[215-494]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[493-759]T$	G3DSA:3.40.50.300
PIRSF002787	$\"[52-760]T$	Hemolysin_sec_B
PTHR19242	$\"[161-760]T$	PTHR19242
PTHR19242:SF91	$\"[161-760]T$	PTHR19242:SF91
SSF52540	$\"[528-760]T$	SSF52540
SSF90123	$\"[156-517]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.4e-64. IPB001140A 543-589 IPB001140B 662-700 IPB001140C 714-743","Residues 709-741 are 66% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383) which is seen in MESD_LEUME.Residues 483-679 are 26% similar to a (ABC TRANSPORTER) protein domain (PD241124) which is seen in Q9U0N4_PLAF7.Residues 595-661 are 70% similar to a (TRANSPORT ATP-BINDING ABC TRANSPORTER) protein domain (PD306522) which is seen in Q9EW69_STRPN.Residues 188-244 are 59% similar to a (ATP-BINDING TRANSPORT COMPETENCE COMA) protein domain (PD155322) which is seen in COMA_STRPN.Residues 82-203 are 68% similar to a (TRANSPORT ATP-BINDING COMPLETE PROTEOME) protein domain (PD003456) which is seen in Q9ETN5_STRPN.Residues 604-661 are 41% similar to a (ATP-BINDING TRANSPORT COMPLETE ABC) protein domain (PD333091) which is seen in Q9ZI23_STRSL.Residues 665-703 are 64% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459) which is seen in MDR1_LEIEN.Residues 559-739 are 26% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD316735) which is seen in Q9PPY0_UREPA.Residues 597-661 are 69% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760) which is seen in Q48553_LEUGE.Residues 595-663 are 72% similar to a (TRANSPORT ATP-BINDING LACTOCOCCIN) protein domain (PD402967) which is seen in COMA_STRPN.Residues 351-458 are 74% similar to a (ATP-BINDING TRANSPORT TRANSPORTER) protein domain (PD331886) which is seen in Q9EW68_STRPN.Residues 220-332 are 60% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348) which is seen in Q48553_LEUGE.Residues 459-540 are 69% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in Q9EW68_STRPN.Residues 713-759 are 46% similar to a (ATP-BINDING TRANSPORT MULTIDRUG RESISTANCE-ASSOCIATED) protein domain (PD188719) which is seen in P73400_SYNY3.Residues 596-661 are 42% similar to a (TRANSPORTER SUBLANCIN ATP-BINDING) protein domain (PD336499) which is seen in Q9XDS0_BBBBB.Residues 544-592 are 61% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in COMA_STRPN.Residues 665-707 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9EW69_STRPN.Residues 518-623 are 29% similar to a (COMPLETE ORF MITOCHONDRION PROTEOME) protein domain (PD000146) which is seen in O77308_PLAFA.Residues 205-537 are 18% similar to a (TRANSPORT ATP-BINDING 481/LACTOCOCCIN) protein domain (PD102152) which is seen in Q9F445_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:30:55 2007","Fri Mar 16 11:30:55 2007","Fri Mar 16 11:30:55 2007","Thu Apr 4 10:03:29 2002","Sun Jan 13 15:35:16 2002","Sun Jan 13 15:35:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0258 is paralogously related (blast p-value < 1e-3) to SMu1710, SMu1724, SMu0837, SMu0825, SMu0476, SMu0986, SMu0475, SMu1064, SMu0824, SMu0836, SMu1065, SMu0024, SMu1723, SMu0987, SMu0971, SMu1517, SMu1920, SMu0390, SMu0418, SMu0218, SMu1003, SMu1950, SMu1757, SMu0517, SMu0916, SMu0849, SMu1545, SMu1001, SMu1036, SMu1762, SMu0235, SMu0884, SMu1079, SMu0594, SMu1380, SMu1949, SMu0786, SMu1246, SMu1231, SMu0950, SMu1518, SMu1068, SMu1751, SMu1210, SMu0907, SMu0335, SMu1093, SMu0805, SMu0234, SMu0731, SMu0976, SMu0944, SMu1316, SMu1023, SMu0823, SMu1288, SMu1037, SMu0216, SMu1649, SMu0164, SMu1410, SMu1811, SMu1428, SMu1959, SMu1725, SMu0752, SMu1306, SMu0596, SMu0224, SMu0374, SMu0729, SMu1050, SMu0666, and SMu1686, ATP-binding proteins.","Sun Jan 13 15:41:40 2002","Fri Mar 16 11:30:55 2007","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 94 7e-020pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 72 3e-013","SMU.286","","Residues 53 to 187 (E-value = 8.6e-64) place SMu0258 in the Peptidase_C39 family which is described as Peptidase C39 family (PF03412)Residues 206 to 482 (E-value = 6.9e-62) place SMu0258 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 554 to 737 (E-value = 1.4e-54) place SMu0258 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Mar 16 11:30:55 2007","24378790","","","","Mon Oct 28 13:16:59 2002","","1","","","SMU.286","" "SMu0259","272924","273826","903","ATGGATCCTAAATTTTTACAAAGTGCAGAATTTTATAGGAGACGCTATCATAATTTTGCGACACTATTAATTGTTCCTTTGGTCTGCTTGATTATCTTCTTGGTCATATTCCTTTGTTTTGCTAAAAAAGAAATTACAGTGATTTCTACTGGTGAAGTTGCACCAACAAAGGTTGTAGATGTTATCCAATCTTACAGTGACAGTTCAATCATTAAAAATAATTTAGATAATAATGCAGCTGTTGAGAAGGGAGACGTTTTAATTGAATATTCAGAAAATGCCAGTCCAAACCGTCAGACTGAACAAAAGAATATTATAAAAGAAAGACAAAAACGAGAAGAGAAGGAAAAGAAAAAACACCAAAAGAGCAAGAAAAAGAAGAAGTCTAAGAGCAAGAAAGCTTCCAAAGATAAGAAAAAGAAATCGAAAGACAAGGAAAGCAGCTCTGACGATGAAAATGAGACAAAAAAGGTTTCGATTTTTGCTTCAGAAGATGGTATTATTCATACCAATCCCAAATATGATGGTGCCAATATTATTCCGAAGCAAACCGAGATTGCTCAAATCTATCCTGATATTCAAAAAACAAGAAAAGTGTTAATCACCTATTATGCTTCTTCTGATGATGTTGTTTCTATGAAAAAGGGGCAAACCGCTCGTCTTTCCTTGGAAAAAAAGGGAAATGACAAGGTTGTTATTGAAGGAAAAATTAACAATGTCGCTTCATCAGCAACTACTACTAAAAAAGGAAATCTCTTTAAGGTTACTGCCAAAGTAAAGGTTTCTAAGAAAAATAGCAAACTCATCAAGTATGGTATGACAGGCAAGACAGTCACTGTCATTGATAAAAAGACTTATTTTGATTATTTCAAAGATAAATTACTGCATAAAATGGATAATTAG","10.60","27.88","34103","MDPKFLQSAEFYRRRYHNFATLLIVPLVCLIIFLVIFLCFAKKEITVISTGEVAPTKVVDVIQSYSDSSIIKNNLDNNAAVEKGDVLIEYSENASPNRQTEQKNIIKERQKREEKEKKKHQKSKKKKKSKSKKASKDKKKKSKDKESSSDDENETKKVSIFASEDGIIHTNPKYDGANIIPKQTEIAQIYPDIQKTRKVLITYYASSDDVVSMKKGQTARLSLEKKGNDKVVIEGKINNVASSATTTKKGNLFKVTAKVKVSKKNSKLIKYGMTGKTVTVIDKKTYFDYFKDKLLHKMDN","273823","For other components see SMu0258 (NBD1) and (MSD1).For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). ","ABC transport protein ComB, accessory factor for ComA","Periplasm, Membrane, Cytoplasm, Extracellular","Limited matches in gapped BLAST to hypotheticals and BlpC ABC transporters. Residues 1-100 and 166-280 are 46% and 51% similar resp. to stretches of gi15900443 in S.pneumoniae. Weaker similarities over these fragments correspond to the predicted comB protein of S.gordonii (gi1698422).SMu0259 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-41]?$	signal-peptide
tmhmm	$\"[21-41]?$	transmembrane_regions

","No hits to the COGs database.","***** IPB002215 (HlyD family secretion protein) with a combined E-value of 2.2e-12. IPB002215A 56-92 IPB002215B 160-194 IPB002215C 272-294","Residues 166-240 are 53% similar to a (TRANSPORT ACCESSORY TRANSMEMBRANE) protein domain (PD007371) which is seen in Q9EU69_STRPN.Residues 1-78 are 44% similar to a (TRANSPORT SECRETION ABC TRANSMEMBRANE) protein domain (PD225235) which is seen in Q9EU69_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:31:10 2007","Sun Jan 13 16:04:26 2002","Fri Mar 16 10:45:43 2007","Sun Jan 13 15:56:00 2002","Sun Jan 13 15:56:00 2002","Sun Jan 13 15:56:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0259 is paralogously related (blast p-value < 1e-3) to SMu1726, and SMu0431, both conserved hypotheticals.","Sun Jan 13 16:05:25 2002","","No significant hits to the NCBI PDB database.","SMU.287","","No significant hits to the Pfam 11.0 database","Sun Jan 13 15:56:00 2002","24378791","","","Lunsford,R.D. and London,J.Natural genetic transformation in Streptococcus gordonii: comXimparts spontaneous competence on strain wickyJ. Bacteriol. 178 (19), 5831-5835 (1996)PubMed: 8824638","","Thu Apr 4 10:04:28 2002","1","","","SMU.287","" "SMu0260","274183","275850","1668","ATGATTATCTTGGATAGAAATAGTTATGACCTTCTTTCTTATTTGATAAAGTTAGAAGAGCCTGAAACAGTGATGAGCATTTCTAAGGTTTTAAATCAGTCCAGACGTAAAGTTTATTACCATCTTGATAAAATAAATGAAGCGCTGCCATCTGAGATTCCGAAAATCATTAGCTATCCTCGCATAGGTATTTTGCTTTCATCACAACAAAAAGCAGCCTGCCGCACTTTGCTAGCAGATTTAGATGATTATTCTTATGTAATGAGTATACAAGAACGTATGCTGCTTAGCATAACTTATATTGCAATTGCTAAAGATCGTGTTACGATTGAAAAGTTGATGCAAATCAATGCAGTTTCCCGTAATACCATTCTCAATGACCTCAATGAACTGCGTCAACGTCTTTCTTTTGAACCATATAGTATTAAGCTTCAGGCAACCAAATCAAAAGGCTATTATTTGGACTGCCATCCTCTGTCTAAAATTCAATATTTAAATAAGCTTCTTCATACTATTTATACAGATAGTAACCCTAATTTTATAGCTATGATGCGTGATAAGCTGAGAGATTTTGCTGATTTGTCTAGTTATTTTTCTGATGATATTTCAAGTTTTATAAGAGGAGAATTGCAGGTTTCCCAAGCATTACTCGGTAAAAAAATCAACAGTCAAGATATCCGTTTTATGGTTGCTACTTTACCTTATCAGCTGTTAAGTTATCAGAACCTAGGTTTATCAGAACGTGAACAAAGAGATTTATTAAGTGAATTTTCTCCTATCAAAGAGCGCAAAGAATATGAAATTGCGAGGCATTTAAATGAGAATCTAAAAAGAGAATTTCATATTGAATTAGATGAGATCGAAACCTCTTTAATTGCTGTTTTGCTTTTGTCGTATCGAAAAGATCGCGATATGCATCTTGAAAGTCATGATTATGATGATATGCGGCGTGTTTTAAGCTATTTTATAGATGCTTTTGAGCTTGATTACCATGTTTGTTTTAAACATAAACAACTCTTACTTAATCAGTTATTAACGCATTGTAAAGCCCTTCTTTTTAGGAAGGCTTATGGCATCGTTTCAAATAATCCGCTAACAGACCAAATTAAAGATAAATATGCAGACTTATTTGCTATGACCAAGGTTTGTCTTTCTATTTTGGAAAATGCTTGGTCTATTAAAATGAATGACGATGATATTGCTTATATCACCATCCACATTGGCGGTGAGTTGGTACATTCTGAGACGAAACCGACACCGCCTGCAGTCTTGACCCTAGTTTGTGATGAAGGCATTGGAGTGCAAAAACTCTTTATGCAGCAGTGCAAGCAATATTTACCTCATAGCAAGATCGAAGCTGTCTTAACATCTGAACAATTTTATAGTGTTGCTGATATTATGGCTGTTGATTTGGTTATTTCAACTAATGACAGTCTCGATACGCAGCTGCCAACTCTTTTTGTCCATTCTATTTTAAGAGATGATGATGCCATTAAATTAATTCGTTTTGCTAAGCAGCGTGGACAAACGGGTCAGGATGATTTTGATAAAAAGTTAGAAACTTATATTCGTCATTATGTTAAGAATGATAGTGATTGTTATGTCCTCAAAACAAAAATTGAAGGCTTAATCAATGAGGAATTGCTTTATGATAATAATAAAAGATAG","6.40","-5.72","64524","MIILDRNSYDLLSYLIKLEEPETVMSISKVLNQSRRKVYYHLDKINEALPSEIPKIISYPRIGILLSSQQKAACRTLLADLDDYSYVMSIQERMLLSITYIAIAKDRVTIEKLMQINAVSRNTILNDLNELRQRLSFEPYSIKLQATKSKGYYLDCHPLSKIQYLNKLLHTIYTDSNPNFIAMMRDKLRDFADLSSYFSDDISSFIRGELQVSQALLGKKINSQDIRFMVATLPYQLLSYQNLGLSEREQRDLLSEFSPIKERKEYEIARHLNENLKREFHIELDEIETSLIAVLLLSYRKDRDMHLESHDYDDMRRVLSYFIDAFELDYHVCFKHKQLLLNQLLTHCKALLFRKAYGIVSNNPLTDQIKDKYADLFAMTKVCLSILENAWSIKMNDDDIAYITIHIGGELVHSETKPTPPAVLTLVCDEGIGVQKLFMQQCKQYLPHSKIEAVLTSEQFYSVADIMAVDLVISTNDSLDTQLPTLFVHSILRDDDAIKLIRFAKQRGQTGQDDFDKKLETYIRHYVKNDSDCYVLKTKIEGLINEELLYDNNKR","275847","","transcriptional antiterminator","Cytoplasm","Similarities in gapped BLAST to transcriptional regulators, e.g. residues 2-549 are 54% similar to gi15674386 from S.pyogenes and 44% similar to gi15903885 from S.pneumoniae.See also similarity to SMu0279, a previously published sorbitol operon regulator.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1801 (1e-175).","

InterPro
IPR011608
Domain

PRD
PF00874	$\"[207-299]T$ $\"[320-410]T$	PRD

InterPro
IPR013011
Domain

Phosphotransferase system, EIIB component, type 2
PS51099	$\"[421-512]T$	PTS_EIIB_TYPE_2

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[93-153]T$	HTH_11

noIPR
unintegrated

unintegrated
G3DSA:1.10.1790.10	$\"[308-407]T$	G3DSA:1.10.1790.10
SSF46785	$\"[4-44]T$ $\"[86-157]T$	SSF46785
SSF52794	$\"[419-506]T$	SSF52794
SSF63520	$\"[186-304]T$ $\"[309-411]T$	SSF63520

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 369-496 are 26% similar to a (REGULATOR PROTEOME COMPLETE) protein domain (PD024189) which is seen in Q9KG92_BACHD.Residues 4-152 are 30% similar to a (PROTEOME COMPLETE YJDC REGULATION) protein domain (PD339335) which is seen in Q9KG92_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Jan 13 16:12:35 2002","Tue Mar 6 13:30:44 2007","Tue Mar 6 13:30:44 2007","Sun Jan 13 16:06:45 2002","","Sun Jan 13 16:06:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0260 is paralogously related (blast p-value < 1e-3) to SMu1454, SMu0889 both predicted transcriptional regulators, and SMu0279, a predicted sorbitol operon regulator.","Sun Jan 13 16:17:08 2002","","No significant hits to the NCBI PDB database.","SMU.289","","Residues 315 to 410 (E-value = 7.8e-23) place SMu0260 in the PRD family which is described as PRD domain (PF00874)","Sun Jan 13 16:06:45 2002","24378792","","","","","","1","","","SMU.289","" "SMu0261","276429","277520","1092","ATGACTAATGTTAAAGATATTACAAGAGAATCATGGATTTTAAGTACTTTCCCAGAATGGGGCACTTGGCTGAACGAAGAAATTGAAGAAGAAGTTGTCCCTGCCAATAACTTTGCTATGTGGTGGCTGGGTAACTGTGGTGTCTGGATTAAAACTCCTGGTGGAGCCAATGTGGTTATGGACTTGTGGTCAAACCGCGGTAAATCAACTAAGAAAGTAAAAGATATGGTTTGGGGTCACCAAATGGCTAATATGGCGGGTGTGCGTAAATTACAACCAAACCTTCGTGTGCAACCGATGGTTATTGATCCATTTGCCATCAACGAATTAGACTACTATCTTGTTTCCCACTTCCACAGTGATCATATTGATATTAATACAGCTGCAGCTATTGTTAATAATCCCAAATTAGACCATGTTAAGTTCGTCGGACCATATGAATGTGGCGAAATCTGGAAAAAATGGGGAGTGCCAGAAGACCGCATTATCGTGATTAAACCGGGTGATTCTTTTGAATTTAAAGATATTAAAGTAACTGCTGTTGAATCCTTTGACCGTACTTGTCTGGTAACCTTACCAGTTGAAGGTGCAAAAGAGAACAATGACGACCTTAAAGGACTTGCTGTTACAGATGAGGAAATGGCTCGCAAGGCAGTTAACTATATCTTTGAAACTCCTGGTGGAACCATCTATCATGGTGCTGATTCTCACTTCTCAAATTACTTTGCTAAACATGGCAAAGACTTTGATATTGATGTTGCTATCAATAACTATGGTGACAACCCAGTTGGTATTCAAGATAAAATGACTTCAATCGATCTCCTTCGTATGGCCGAGAATCTTCGTGCCAAAGTCATCATTCCTGTTCACTACGATATCTGGTCTAATTTCATGGCTTCAACAGATGAAATTCTTGTCCTTTGGAAGATGCGTAAAGAACGTTTGCAATATCAATTCCATCCTTTCATTTGGGAAGTTGGTGGTAAATACACTTACCCACAAGATAAGGATAGAATTGAATATCATCACCCACGCGGTTTTGATGACTGCTTTGAGCATGATTCTAATATCCAGTTCAAAGCCCTCCTATAA","5.50","-11.03","41852","MTNVKDITRESWILSTFPEWGTWLNEEIEEEVVPANNFAMWWLGNCGVWIKTPGGANVVMDLWSNRGKSTKKVKDMVWGHQMANMAGVRKLQPNLRVQPMVIDPFAINELDYYLVSHFHSDHIDINTAAAIVNNPKLDHVKFVGPYECGEIWKKWGVPEDRIIVIKPGDSFEFKDIKVTAVESFDRTCLVTLPVEGAKENNDDLKGLAVTDEEMARKAVNYIFETPGGTIYHGADSHFSNYFAKHGKDFDIDVAINNYGDNPVGIQDKMTSIDLLRMAENLRAKVIIPVHYDIWSNFMASTDEILVLWKMRKERLQYQFHPFIWEVGGKYTYPQDKDRIEYHHPRGFDDCFEHDSNIQFKALL","277517","","conserved hypothetical protein","Cytoplasm, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 1-363 are 87% similar to gi|15674387 from S.pyogenes and to gi|15901852 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1800 (0.0).","

noIPR
unintegrated

unintegrated
PD135310	$\"[1-363]T$	PD135310
SSF56281	$\"[37-341]T$	SSF56281

","BeTs to 5 clades of COG2220COG name: Predicted Zn-dependent hydrolases of the beta-lactamase foldFunctional Class:� RThe phylogenetic pattern of COG2220 is AmtKy-VceBR----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-363 are 77% similar to a (PROTEOME COMPLETE VCA0248 PM0763) protein domain (PD135310) which is seen in Q9CMQ2_PASMU.Residues 96-163 are 35% similar to a (PROTEOME COMPLETE C04023 VC0376) protein domain (PD350043) which is seen in Y906_MYCTU.Residues 19-299 are 20% similar to a (VNG0851C PROTEOME COMPLETE) protein domain (PD319560) which is seen in Q9HR59_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 12:09:30 2002","Mon Jan 14 12:09:30 2002","Mon Jan 14 12:09:30 2002","Mon Jan 14 12:09:30 2002","","Mon Jan 14 12:09:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0261 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 12:09:30 2002","","No significant hits to the NCBI PDB database.","SMU.290","","No significant hits to the Pfam 11.0 database","Mon Jan 14 12:09:30 2002","24378793","","","","","","1","","","SMU.290","" "SMu0262","277894","279870","1977","ATGTCAGATTTATCGGTTAATGCCATTCGCTTTTTAGGGGTAGATGCTATTGAAAAGTCTAAGTCGGGTCACCCGGGTGTTGTCATGGGCGCTGCCCCAATGGCTTACAGTCTATATACTAAGCATTTACGTGTTAACCCAAGTCAGCCAAATTGGATTAACCGTGACCGTTTTGTTTTGTCAGCTGGTCATGGCTCAATGCTTTTATATGCTCTCTTGCACTTGTCGGGATTTGAAGATATTTCTATTGATGAAATCAAAAATTTCCGTCAGTGGGGCTCTAAAACACCGGGGCACCCTGAGTATGGCCATACCGTAGGTGTTGATGTGACAACAGGCCCTCTTGGCCAAGGGATTTCAATGGCTGTTGGTTTGGCTCAAGCTGAACGTTTCTTAGCTGCTAAATACAATCGTGAAGGCTACCCTATTTTTGATCACTATACTTATGTTATTGCCGGTGATGGTGATTTTATGGAAGGTGTTTCTGGCGAAGCGTCATCCTATGCTGCCAAACAAAATTTGGATAAACTGATTGTTCTTTATGATTCTAATGATATTTGTTTGGATGGTGAAACCAATGATGCGTTCACTGAAAGTGTTCGTGCACGATATGATGCTTATGGATGGCATACAATCTTAGTTGAAGATGGCAATAATATTGAAGCTATTGGACTTGCTATTGAAGAAGCAAAGGCAGCTGGCAAACCTTCTCTTATTGAAATTAAAACTGTGATTGGCTACGGTGCTCCAACTAAAGGCGGTACCAATGCTGTTCATGGTGCACCACTTGGAGCTGAAGAAGCAGCTGCTACTCGTAAGGCTCTCAATTGGGGTTATGCTCCTTTTGAAGTTCCTCAAGAGGTTTATGATGATTTCAAAGAAAATGTTGCGGATCGTGGTGAAGCTGCTTACGATGCTTGGTCAAATCTTGTTGGAGAATATCGACAAGCTTATCCTAAAGAGGCGCGTGAAGTGGATGCAATTATTGATGGAAAAGATCCTGTGGAAATCAAAGAAGCTGATTTTCCAGTCTACGAAAATGGTTTCTCTCAAGCAACGCGTAATTCTAGTCAAGATGCCATCAATGCTGCGGCAGACGTACTACCTAACTTTCTTGGAGGATCTGCTGATCTTGCGCATTCTAACATGACTTACATTAAAGCAGATGGGCTTCAAGATGCTGATCATCCGCTTAACCGTAACATCCAGTTTGGTGTTCGTGAATTTGCTATGGGTACTGTCTTAAATGGTATGGCTCTTCATGGCGGACTGCGTGTTTATGGCGGTACCTTCTTTGTCTTTTCAGACTATCTCAAAGCAGCTGTTCGTTTGTCAGCCCTTCAAGGAGTACCAGTAACTTATGTCTTTACCCACGATTCGATTGCCGTTGGTGAAGATGGCCCTACTCATGAACCGATTGAACACTTGGCAGGTTTACGTGCCACTCCTAATTTGGTTGTTTTTCGCCCAGCTGATGCACGCGAAACACAGGCAGCATGGCATTATGCTTTGACAAGCCAAAACACACCAACAGCTCTTGTTTTGACACGTCAAAATCTTGATGTTGAAGCTGGTTCAAGCTTTACTTCAGTTGCTAAGGGAGCTTATGTTACTTATGAAACAGATTCTGACTTTAATACCATTCTTTTGGCATCAGGTTCTGAAGTTAACTTAGCAGTCAAAGCAGCTAAGGAATTGGAAGCACAAGGCGAAAAAGTACGTGTTGTTTCTGTTCCTTCTACAGAGCTCTTTGATGAGCAATCTGCTGCCTACAAAGAAGCTATTTTACCAAATTCAGTACGCCGTCGTGTAGCCATTGAAATGGCAGCCAGCCAACCATGGTATAAATATGTTGGTCTTGATGGTGCGGTTATCGGTATTGATAAATTTGGAGCATCAGCTCCTGCTGCTCAAGTCATTGAAAATTATGGCTTTACAGTAGATAATGTGGTTAAAGTTGTTAAGGAACTGAAATAG","4.80","-26.13","71067","MSDLSVNAIRFLGVDAIEKSKSGHPGVVMGAAPMAYSLYTKHLRVNPSQPNWINRDRFVLSAGHGSMLLYALLHLSGFEDISIDEIKNFRQWGSKTPGHPEYGHTVGVDVTTGPLGQGISMAVGLAQAERFLAAKYNREGYPIFDHYTYVIAGDGDFMEGVSGEASSYAAKQNLDKLIVLYDSNDICLDGETNDAFTESVRARYDAYGWHTILVEDGNNIEAIGLAIEEAKAAGKPSLIEIKTVIGYGAPTKGGTNAVHGAPLGAEEAAATRKALNWGYAPFEVPQEVYDDFKENVADRGEAAYDAWSNLVGEYRQAYPKEAREVDAIIDGKDPVEIKEADFPVYENGFSQATRNSSQDAINAAADVLPNFLGGSADLAHSNMTYIKADGLQDADHPLNRNIQFGVREFAMGTVLNGMALHGGLRVYGGTFFVFSDYLKAAVRLSALQGVPVTYVFTHDSIAVGEDGPTHEPIEHLAGLRATPNLVVFRPADARETQAAWHYALTSQNTPTALVLTRQNLDVEAGSSFTSVAKGAYVTYETDSDFNTILLASGSEVNLAVKAAKELEAQGEKVRVVSVPSTELFDEQSAAYKEAILPNSVRRRVAIEMAASQPWYKYVGLDGAVIGIDKFGASAPAAQVIENYGFTVDNVVKVVKELK","279867","","transketolase","Cytoplasm","Matches in gapped BLAST to transketolase sequences. Residues 1-658 are 78% similar to the enzyme from S.pneumoniae (gi|15901851). Residues 4-657 are 60% similar to gi|16800411 from L.inocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0278 (0.0).","

InterPro
IPR005474
Domain

Transketolase, N-terminal
PF00456	$\"[1-334]T$	Transketolase_N
PS00801	$\"[10-30]T$	TRANSKETOLASE_1

InterPro
IPR005475
Domain

Transketolase, central region
PF02779	$\"[349-522]T$	Transket_pyr
PS00802	$\"[464-480]T$	TRANSKETOLASE_2

InterPro
IPR005476
Domain

Transketolase, C-terminal
PF02780	$\"[532-650]T$	Transketolase_C

InterPro
IPR005478
Family

Bacterial transketolase
PIRSF000418	$\"[1-658]T$	Transketolase
PTHR11624:SF1	$\"[14-653]T$	BacTransketolase
TIGR00232	$\"[3-658]T$	tktlase_bact

InterPro
IPR009014
Domain

Transketolase, C-terminal-like
G3DSA:3.40.50.920	$\"[533-657]T$	Transketo_C_like
SSF52922	$\"[524-657]T$	Transketo_C_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.970	$\"[1-331]T$ $\"[335-533]T$	G3DSA:3.40.50.970
PTHR11624	$\"[14-653]T$	PTHR11624
SSF52518	$\"[3-322]T$ $\"[329-524]T$	SSF52518

","BeTs to 12 clades of COG0021COG name: TransketolaseFunctional Class:� GThe phylogenetic pattern of COG0021 is -m--YqVCEbrhujgp-lin-Number of proteins in this genome belonging to this COG is 1","***** IPB000360 (Transketolase) with a combined E-value of 1e-46. IPB000360A 23-34 IPB000360B 36-75 IPB000360C 463-492","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 12:19:01 2002","Mon Jan 14 12:10:30 2002","Mon Jan 14 12:19:01 2002","Mon Jan 14 12:10:30 2002","Mon Jan 14 12:10:30 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0262 is paralogously related (blast p-value < 1e-3) to SMu0113, a predicted acetoin dehydrogenase.","Mon Jan 14 12:27:56 2002","Mon Jan 14 12:10:30 2002","pdb|1TKB|A Chain A, Transketolase (E.C.2.2.1.1) Complexed With ... 537 2e-153pdb|1TRK|A Chain A, Transketolase (E.C.2.2.1.1) >gi|515260|pdb|... 537 2e-153pdb|1AY0|A Chain A, Identification Of Catalytically Important R... 533 3e-152","SMU.291","","Residues 1 to 334 (E-value = 1.8e-214) place SMu0262 in the Transketolase_N family which is described as Transketolase, thiamine diphosphate binding domain (PF00456)Residues 351 to 522 (E-value = 1.8e-65) place SMu0262 in the Transket_pyr family which is described as Transketolase, pyridine binding domain (PF02779)Residues 532 to 650 (E-value = 8.1e-08) place SMu0262 in the Transketolase_C family which is described as Transketolase, C-terminal domain (PF02780)","Mon Jan 14 12:10:30 2002","24378794","","","Kochetov GA.Functional flexibility of the transketolase molecule.Biochemistry (Mosc). 2001 Oct;66(10):1077-85.PMID: 11736629Gershanovich VN, Kukanova AIa, Galushkina ZM, Stepanov AI.[Transketolase mutation in riboflavin-synthesizing strains of Bacillus subtilis]Mol Gen Mikrobiol Virusol. 2000;(3):3-7. Russian.PMID: 10975072","","Mon Jan 14 12:19:01 2002","1","","","SMU.291","33" "SMu0263","280397","281398","1002","TTGGCTGTTCAAGTTGGACTTGGGGTAATGATTATGAAACTGATGATTACGAAACAATTTCAGTCTTTCCTACAAGAATTGGGAATAGATATCAGGCTGGTTTTACAAAAAGCACAGCTTCCTAATAAGCTGTGGCAAGAAGAGCTTACTTATAATGCTCAGGAGTACTATTGTTTTATAGCAACCTTAGATAAGCTGATTACAGATGAAGCCTTGTTAGCTTTGAGCAGAATTGAAAACATTAAGAAGTTTGTGCCAGCCTTTTTTGCTGCTTTGGCAAGTCCTGATGGTTTGACGGCTTTACAGCGTTTTTCGAAATATAAAAGTTTGATTGGTCCAGTAAAAGTACAGCTTGAAGACAGCGAAGATGAAATTTCTGTAAGTTATGCCTACCGTTCATCACAGCTTCCGCTTCCTCGCATGTTATTGCTGCAGGAACAGTTGCTTCTTTTAAGTCTCTTACGGACGGGAACAGGGACTTGCATTCTTCCTTACGAAATAAGTTCTCCTTATGATTATGGAAGACTTCTTGAGAAGGAAGTAGGAATCCTGCCGAAAAAAACAGATTATAATCGTTTAGTATTATCTAAAGCAGATCTTGAAAAACCTTTTATCACTGAAAATAATGTCATGTGGTATCATTTGAAGTTAAGTCTTAATCAGCAGTTGTCCCAGCTTCATAGTGATGACAATTTCACTCAGGCCGTTCAGACAGAGTTGCTGTCTGCCATCCCTAGTGGACAATTTTCCCTTGCAATGATAGCTAACAGACTAGGACTCAGTGCCCGTACCCTGCAACGTAAATTGGCTGCTGAGGATACAACTTTTAATGAGGAAGTTTTACATATGCAAAAATTGATGACTTTTTCCTATCTTGACTTATCTATGTCAGTTGATGAGATTGCTTATTTAGTAGGCTACTCAGAAAAGTCCAGCTTTCTGCGGGCCTTTAAAAAATGGACCGGCAAGACATTAAAGAAGTATAAGGAAACCGCTCTTTAA","8.10","1.64","37923","MAVQVGLGVMIMKLMITKQFQSFLQELGIDIRLVLQKAQLPNKLWQEELTYNAQEYYCFIATLDKLITDEALLALSRIENIKKFVPAFFAALASPDGLTALQRFSKYKSLIGPVKVQLEDSEDEISVSYAYRSSQLPLPRMLLLQEQLLLLSLLRTGTGTCILPYEISSPYDYGRLLEKEVGILPKKTDYNRLVLSKADLEKPFITENNVMWYHLKLSLNQQLSQLHSDDNFTQAVQTELLSAIPSGQFSLAMIANRLGLSARTLQRKLAAEDTTFNEEVLHMQKLMTFSYLDLSMSVDEIAYLVGYSEKSSFLRAFKKWTGKTLKKYKETAL","281395","","transcriptional regulator, probable AraC family","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Residues 12-317 are 38% similar to gi|15673292 from L.lactis lactis. Residues 236-317 are 40% similar to an AraC fragment from C.crescentus (gi|16124890).SMu0263 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000005
Domain

Helix-turn-helix, AraC type
PR00032	$\"[298-313]T$ $\"[313-329]T$	HTHARAC
PF00165	$\"[290-330]T$	HTH_AraC
SM00342	$\"[248-329]T$	HTH_ARAC
PS01124	$\"[230-331]T$	HTH_ARAC_FAMILY_2

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide

","No hits to the COGs database.","***** IPB000005 (AraC type helix-turn-helix) with a combined E-value of 2e-10. IPB000005 298-329","Residues 250-317 are 52% similar to a (TRANSCRIPTION REGULATION DNA-BINDING TRANSCRIPTIONAL) protein domain (PD000394) which is seen in Q9CG01_LACLA.Residues 12-247 are 34% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD400817) which is seen in Q9CG01_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 12:28:49 2002","Mon Jan 14 12:24:36 2002","Thu Oct 24 14:40:27 2002","Mon Jan 14 12:24:36 2002","Mon Jan 14 12:24:36 2002","Mon Jan 14 12:24:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0263 is paralogously related (blast p-value < 1e-3) to SMu0799, a predicted MSM operon regulatory protein.","Mon Jan 14 12:28:49 2002","","No significant hits to the NCBI PDB database.","SMU.292","","Residues 287 to 330 (E-value = 6.5e-05) place SMu0263 in the HTH_AraC family which is described as Bacterial regulatory helix-turn-helix proteins, araC family (PF00165)","Mon Jan 14 12:24:36 2002","24378795","","","","","","1","","","SMU.292","" "SMu0264","281529","282041","513","ATGACAGCAGCACTATTCGCTTTTATCGCTATAACGCTTTTTATGATACACGAGTTTGAAGAAATAATTTTAGTTTGTCCATGGATTGCTAAGAACAAGAGCAATCCCAAATTTGCCAATGAGATATTTATCTCAGGCAGAAAGCATTACCCTTCAGCAGAAAATATTGCAGTGGCTGTCTTAGAAGAGTTTGTTTTAGCTAGTCTGATTCTGCTTGCAGGCATTCTTTTTAGAGTACCAGAGTTGGTATTAGCTATCACATTGGGACATACTTTCCATCTTTTTTCTCATATTTCTCAAGCCATTACCTATCGTACATGGGTACCCGGAAGTATCACTGCAGCATTAACTCTTCCTTTACTGGTTATGGCTATCATGGGATTTTGTTTTGCTCAGACACTTAGCTGGATGCTTTTATTGATGCTGACAGTCCTTATATTCCCTCTTCAGTTGGTTAATCTACGCTTTATTCATCAGCATACTGACAAAGTCGAAAAATTCCTGCATTCGTAA","7.70","1.82","19192","MTAALFAFIAITLFMIHEFEEIILVCPWIAKNKSNPKFANEIFISGRKHYPSAENIAVAVLEEFVLASLILLAGILFRVPELVLAITLGHTFHLFSHISQAITYRTWVPGSITAALTLPLLVMAIMGFCFAQTLSWMLLLMLTVLIFPLQLVNLRFIHQHTDKVEKFLHS","282038","","hypothetical protein","Membrane, Cytoplasm","No significant matches in gapped BLAST.SMu0264 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-85]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[64-86]?$ $\"[107-129]?$ $\"[135-155]?$	transmembrane_regions

InterPro
IPR007492
Domain

LytTr DNA-binding region
PF04397	$\"[61-158]T$	LytTR
PS50930	$\"[55-159]T$	HTH_LYTTR

InterPro
IPR012360
Family

LytTR_ LMO transcriptional regulator, putative
PIRSF031486	$\"[15-161]T$	LMO_LytTR

noIPR
unintegrated

unintegrated
signalp	$\"[1-41]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[31-51]?$ $\"[63-83]?$ $\"[89-111]?$	transmembrane_regions

InterPro
IPR013332
Domain

Ketopantoate reductase ApbA/PanE, N-terminal
PF02558	$\"[3-161]T$	ApbA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-102]T$	G3DSA:3.40.50.720
SSF51735	$\"[1-191]T$	SSF51735

","BeTs to 3 clades of COG1893COG name: Ketopantoate reductase PanE/ApbAFunctional Class:� HThe phylogenetic pattern of COG1893 is a--kyq--eBr----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 12:38:08 2002","Mon Jan 14 12:38:08 2002","Mon Jan 14 12:38:08 2002","Mon Jan 14 12:38:08 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0267 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 12:38:08 2002","","No significant hits to the NCBI PDB database.","SMU.296","","No significant hits to the Pfam 11.0 database","Mon Jan 14 12:38:08 2002","24378799","","","","","","1","","","SMU.296","" "SMu0268","284102","286738","2637","ATGACAAACAAGAAAAAATTATTATTGATTGACGGCTCTTCCGTTGCTTATCGTGCTTTCTTTGCACTTTATAATCAAATTGACCGCTTTAAAAATCCTGCTGGTTTACACACCAATGCCATTTATGGCTTTCATTTAATGTTGGATCATATGATGAAAAGGGTGGAACCGACGCATGTTTTAGTGGCTTTTGATGCTGGGAAAACAACCTTTCGAACAGAAATGTTTGCAGACTATAAGGCGGGCCGTGCTAAAACGCCGGAAGAATTTCGTGAGCAGCTACCTTATATTAGAGAGATGCTGACCGCTTTAGGTGTTTCCTATTATGATTTGGAAAATTATGAAGCTGATGACATTATTGGAACCCTTGATAAATTAGCCGAAAATGAGGATGAATATGATGTTACTATTGTCAGCGGTGATAAGGACCTCATTCAGCTGACTGATAGTAATACGACTGTTGAGATTTCCAAAAAAGGTGTTGCTGAATTTGAAGAATTTACACCAGACTATCTCATGGAAAAAATGGGACTGACGCCTAAGCAATTTATTGATCTCAAGGCTCTCATGGGGGACAAATCTGATAATATTCCGGGGGTAACAAAAATTGGTGAGAAGACAGGTTTGAAACTGTTGCATGAACATGGCAGTCTAGAAGCTATCTATGAACATATTGATAGCTTTAAAACGACTAAGATGAAGGAAAATCTCATCAACGATAAAGAAAAGGCTTTTCTTTCTAAAACACTGGCAACCATTGATACGCAAGCACCGATCACCATCACTTTAGATGATATTGATTACTCTGGTCCTCAGCTTGATGCACTGGCTAAGTTTTATGACGAAATGGACTTCAGACAATTTCGATCACAACTTGACAGTTCACCTAAAACCGAAAATTTTGAAGTGAGTTATACAGAAGTGACTGAACTCAAGCCTGATATGTTTGCGCCTGATCAATTCTTTTATTTTGAAATTTTGAATGATAATTATCATACCCAAGAGATGATCGGTCTGGCTTGGGGAGATGACCAAGCGATTTATGCGACAACTGATACCAGTTTGCTGACGCATGATTTGTTTAAAGAAGCCTTGTCAAAACCTATTAAAACTTATGATTTTAAGCGCGGTAAGGTCTTGCTGAGTCATTTGGGCATTGATCTGCCGACAGCTAGTTTCGATAGTCGTTTGGCCAAATATTTGCTGTCAACTGTTGAAAATAATAACATTTCGACCATTGCAAGACTTTACACAGATTTACCTTTAGAAACAGACGATGATGTGTATGGTAAAGGAGCTAAACGTGCTATCCCAGAAAAAAATGTTCTGCTCAGCCATTTAGCTAAAAAAATCAGTGTCTTGCTTGCTAGCGAAGAGCCGATGCGTCAGAAACTGTCTGCCAATGACCAACTGGACTTGCTTTTTGAGATGGAATTACCGCTGGCAAATGTGTTGGCTAAAATGGAAATTGCAGGTATTTCGGTTAGAAAAGAAACGCTGCAGGACATGGAACGGGCTAATGAGATTGAATTGCAGGCTCTGACTCAGGAGATTTATGATTTAGCTGGTGAGGCGTTCAATATTAATTCTCCAAAACAATTGGGAGTTATCCTCTTTGAAAAATTGGGTCTGCCCTTGTCAGCCACTAAAAAGACGAAAACAGGTTATTCAACAGCTGTTGATGTCTTGGAACGTCTGGCTCATCGTTCACCAATCGTTGCTAAAATTTTAGAATATCGTCAAATTGCGAAATTGCAATCCACCTATATCATTGGCTTGCAAGATTCGATTTCCTTTGATGGCAAGATTCATACCCGTTATTTGCAAGATTTAACGCAAACTGGCCGCTTATCCAGCGTTGATCCTAATTTACAAAATATTCCTGTGCGTTTGGAACAGGGACGTCTTATTCGCAAGGCTTTTGTTCCTGAATGGAAAGAGAGTGTTCTGCTCAGTTCAGATTATTCACAAATTGAATTGCGGGTGCTGGCTCATATTTCAGGCGATGAACATTTAATTGCTGCTTTTAAGGAAGGAGCAGACATTCACACCTCTACAGCCATGCGTGTCTTTGGTATTGAAAGACCAGAAGACGTCACTCCTAATGACCGCCGCAATGCTAAGGCTGTTAACTTTGGTGTGGTTTATGGCATTTCTGATTTTGGTCTGGCTAATAATTTGGGTATTAGCCGCAAAGCCGCTAAGAATTACATTGAAACCTATTTTGAACGTTATCCGGGAATTAAAAATTATATGGATAGAGTGGTGCGAGAAGCGCGTGATAAGGGTTATGTTGAAACGCTCTTTCATCGCCGCCGTGAATTACCGGATATCAATTCACGCAATTTCAATATTCGGTCTTTTGCGGAGCGAACAGCTATTAACTCGCCTATTCAGGGTAGCGCCGCTGATATTCTTAAAGTGGCCATGATTCATCTCGATCAAGCCTTGAAAAAAGGAGATTATCAATCGCGGATGCTCCTGCAGGTGCATGATGAAATTGTCCTTGAGGTGCCAAATGCTGAACTTGAAGCGATCCAAAAGTTGGTCAAGGAAACCATGGAATCTGCTATTGAACTTTCTGTACCACTTGTGGCAGATGAAAATGCAGGGCAGACTTGGTATGAGGCAAAGTAA","5.10","-25.30","99451","MTNKKKLLLIDGSSVAYRAFFALYNQIDRFKNPAGLHTNAIYGFHLMLDHMMKRVEPTHVLVAFDAGKTTFRTEMFADYKAGRAKTPEEFREQLPYIREMLTALGVSYYDLENYEADDIIGTLDKLAENEDEYDVTIVSGDKDLIQLTDSNTTVEISKKGVAEFEEFTPDYLMEKMGLTPKQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEHGSLEAIYEHIDSFKTTKMKENLINDKEKAFLSKTLATIDTQAPITITLDDIDYSGPQLDALAKFYDEMDFRQFRSQLDSSPKTENFEVSYTEVTELKPDMFAPDQFFYFEILNDNYHTQEMIGLAWGDDQAIYATTDTSLLTHDLFKEALSKPIKTYDFKRGKVLLSHLGIDLPTASFDSRLAKYLLSTVENNNISTIARLYTDLPLETDDDVYGKGAKRAIPEKNVLLSHLAKKISVLLASEEPMRQKLSANDQLDLLFEMELPLANVLAKMEIAGISVRKETLQDMERANEIELQALTQEIYDLAGEAFNINSPKQLGVILFEKLGLPLSATKKTKTGYSTAVDVLERLAHRSPIVAKILEYRQIAKLQSTYIIGLQDSISFDGKIHTRYLQDLTQTGRLSSVDPNLQNIPVRLEQGRLIRKAFVPEWKESVLLSSDYSQIELRVLAHISGDEHLIAAFKEGADIHTSTAMRVFGIERPEDVTPNDRRNAKAVNFGVVYGISDFGLANNLGISRKAAKNYIETYFERYPGIKNYMDRVVREARDKGYVETLFHRRRELPDINSRNFNIRSFAERTAINSPIQGSAADILKVAMIHLDQALKKGDYQSRMLLQVHDEIVLEVPNAELEAIQKLVKETMESAIELSVPLVADENAGQTWYEAK","286735","For other 'pol' genes see SMu0110 (polC).","DNA polymerase I","Cytoplasm, Extracellular","Numerous matches in gapped BLAST to PolI sequences. Residues 1-876 are 76% similar to the enzyme from S.pyogenes (gi|15674390). Residues 3-878 are 73% similar to the enzyme from S.pneumoniae (gi|15899978).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0389 (0.0).","

InterPro
IPR001098
Family

DNA-directed DNA polymerase
PF00476	$\"[495-877]T$	DNA_pol_A
SM00482	$\"[634-842]T$	POLAc
PS00447	$\"[704-723]T$	DNA_POLYMERASE_A

InterPro
IPR002298
Family

DNA polymerase A
PR00868	$\"[603-625]T$ $\"[626-641]T$ $\"[649-672]T$ $\"[679-692]T$ $\"[704-729]T$ $\"[741-752]T$ $\"[763-774]T$ $\"[795-811]T$ $\"[825-838]T$	DNAPOLI
TIGR00593	$\"[7-878]T$	pola

InterPro
IPR002421
Domain

5'-3' exonuclease
PF01367	$\"[178-278]T$	5_3_exonuc
PF02739	$\"[5-176]T$	5_3_exonuc_N
SM00475	$\"[5-269]T$	53EXOc

InterPro
IPR002562
Domain

3'-5' exonuclease
SM00474	$\"[288-466]T$	35EXOc

InterPro
IPR008918
Domain

Helix-hairpin-helix motif, class 2
SM00279	$\"[180-215]T$	HhH2
SSF47807	$\"[178-296]T$	5_3_exo_C

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[301-468]T$	RNaseH_fold

noIPR
unintegrated

unintegrated
G3DSA:1.10.150.20	$\"[658-802]T$	G3DSA:1.10.150.20
G3DSA:1.20.1060.10	$\"[491-606]T$	G3DSA:1.20.1060.10
G3DSA:3.30.420.10	$\"[301-490]T$	G3DSA:3.30.420.10
G3DSA:3.40.50.1010	$\"[4-214]T$	G3DSA:3.40.50.1010
PTHR10133	$\"[9-412]T$ $\"[433-878]T$	PTHR10133
SSF56672	$\"[469-878]T$	SSF56672
SSF88723	$\"[4-177]T$	SSF88723

","BeTs to 11 clades of COG0749COG name: DNA polymerase I - 3'-5' exonuclease and polymerase domainsFunctional Class: LThe phylogenetic pattern of COG0749 is ----yqvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001098 (Replicative DNA polymerase) with a combined E-value of 1.4e-101. IPB001098A 11-22 IPB001098B 480-493 IPB001098C 522-541 IPB001098D 602-628 IPB001098E 654-665 IPB001098F 678-688 IPB001098G 704-717 IPB001098H 793-811 IPB001098I 823-842 IPB001098J 862-874","Residues 456-524 are 43% similar to a (DNA I POLYMERASE REPLICATION) protein domain (PD389899) which is seen in DPO1_BACST.Residues 5-292 are 78% similar to a (DNA POLYMERASE I EXONUCLEASE) protein domain (PD002066) which is seen in DPO1_STRPN.Residues 560-859 are 84% similar to a (DNA POLYMERASE I TRANSFERASE) protein domain (PD001497) which is seen in DPO1_STRPN.Residues 824-876 are 47% similar to a (DNA POLYMERASE I TRANSFERASE) protein domain (PD335608) which is seen in Q9RMM6_STAAU.Residues 51-253 are 27% similar to a (PROTEOME COMPLETE) protein domain (PD125594) which is seen in Q9ZM21_HELPJ.Residues 526-567 are 80% similar to a (DNA POLYMERASE I DNA-DIRECTED) protein domain (PD334927) which is seen in DPO1_BACSU.Residues 576-818 are 48% similar to a (DNA POLYMERASE TRANSFERASE DNA-DIRECTED) protein domain (PD264287) which is seen in Q9F191_TREHY.Residues 448-523 are 36% similar to a (DNA I POLYMERASE PROTEOME) protein domain (PD283676) which is seen in Q9K854_BACHD.Residues 524-589 are 60% similar to a (DNA POLYMERASE I TRANSFERASE) protein domain (PD354859) which is seen in Q9PIG2_CAMJE.Residues 465-546 are 32% similar to a (DNA POLYMERASE ATP-BINDING TRANSFERASE) protein domain (PD136799) which is seen in O65531_ARATH.Residues 526-559 are 88% similar to a (DNA I POLYMERASE TRANSFERASE) protein domain (PD373799) which is seen in DPO1_STRPN.Residues 303-447 are 46% similar to a (DNA I POLYMERASE TRANSFERASE) protein domain (PD010044) which is seen in DPO1_STRPN.Residues 454-523 are 60% similar to a (DNA I POLYMERASE PROTEOME) protein domain (PD002801) which is seen in DPO1_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 10:37:30 2002","Mon Jan 14 12:39:58 2002","Mon Jan 14 12:47:12 2002","Thu Oct 10 10:37:30 2002","Mon Jan 14 12:39:58 2002","Mon Jan 14 12:39:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0268 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 12:47:12 2002","Mon Jan 14 12:39:58 2002","pdb|1XWL| Bacillus Stearothermophilus (Newly Identified Stra... 552 5e-158pdb|2BDP|A Chain A, Crystal Structure Of Bacillus Dna Polymeras... 551 1e-157pdb|1BGX|T Chain T, Taq Polymerase In Complex With Tp7, An Inhi... 510 2e-145","SMU.297","","Residues 5 to 176 (E-value = 6.4e-94) place SMu0268 in the 5_3_exonuc_N family which is described as 5'-3' exonuclease, N-terminal resolvase-like domain (PF02739)Residues 178 to 278 (E-value = 3e-53) place SMu0268 in the 5_3_exonuc family which is described as 5'-3' exonuclease, C-terminal SAM fold (PF01367)Residues 495 to 877 (E-value = 1e-208) place SMu0268 in the DNA_pol_A family which is described as DNA polymerase family A (PF00476)","Thu Oct 10 10:37:30 2002","24378800","","","Phang,S.M., Teo,C.Y., Lo,E. and Wong,V.W.Cloning and complete sequence of the DNA polymerase-encoding gene(BstpolI) and characterisation of the Klenow-like fragment fromBacillus stearothermophilusGene 163 (1), 65-68 (1995)PubMed: 7557480Kiefer,J.R., Mao,C., Hansen,C.J., Basehore,S.L., Hogrefe,H.H.,Braman,J.C. and Beese,L.S.Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolutionStructure 5 (1), 95-108 (1997)PubMed: 9016716Kiefer,J.R., Mao,C., Braman,J.C. and Beese,L.S.Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystalNature 391 (6664), 304-307 (1998)PubMed: 9440698","","Thu Apr 4 14:02:27 2002","1","","","SMU.297","50" "SMu0269","286831","287259","429","ATGGCTTATCAATTTCAAAATCCTAGTCAACATGTCATCTTTGATTATGTAAAAAGGGCCAAGACGATTGCAATAGTTGGCTTATCTGCAAGAAAAGAGACAGCAGCTTATGATGTTGCTCAGGTATTGCAAAGTGCTGGTTATAAAATTATTCCTGTTAATCCTAGGGCTGTTGGTGATGAGATTTTGGGTGAAACGGTTTATGCTCGCCTGCAGGATATTCCCGAACATATTGATATTGTGGATGTTTTTCGCCGCAGTGACTTTTTAGCAGATGTTGCTAGGGATTTCATTGAAACAGATGCAGATGTTTTTTGGGCACAATTGGGACTGCAAAGCCAAGAAGCGGAAAAAATATTACGGTTTGCCGGTTGTGACCAGATTGTCATGAATAAATGTCTTAAAATTGAATATCTCAAGTTAAACTAA","5.00","-3.62","16079","MAYQFQNPSQHVIFDYVKRAKTIAIVGLSARKETAAYDVAQVLQSAGYKIIPVNPRAVGDEILGETVYARLQDIPEHIDIVDVFRRSDFLADVARDFIETDADVFWAQLGLQSQEAEKILRFAGCDQIVMNKCLKIEYLKLN","287256","","conserved hypothetical protein","Cytoplasm","Matches to conserved hypothetical proteins in gapped BLAST, e.g.residues 1-141 are 62% similar to gi|15674391 from S.pyogenes. Residues 3-138 are 66% similar to gi|15672137 from L.lactis lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0390 (8e-51).","

InterPro
IPR003781
Domain

CoA-binding
PF02629	$\"[16-108]T$	CoA_binding

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[8-141]T$	G3DSA:3.40.50.720
SSF51735	$\"[8-142]T$	SSF51735

","BeTs to 5 clades of COG1832COG name: Uncharacterized ACRFunctional Class:� SThe phylogenetic pattern of COG1832 is ---k-qv-eb-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 18-138 are 66% similar to a (PROTEOME COMPLETE SUCCINYL-COA SYNTHETASE) protein domain (PD001432) which is seen in Q9CJ51_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 15:41:30 2002","Mon Jan 14 15:41:30 2002","Mon Jan 14 15:41:30 2002","Mon Jan 14 15:41:30 2002","","Mon Jan 14 15:41:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0269 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 15:41:30 2002","","No significant hits to the NCBI PDB database.","SMU.298","","Residues 17 to 126 (E-value = 1.3e-11) place SMu0269 in the CoA_binding family which is described as CoA binding domain (PF02629)","Mon Jan 14 15:41:30 2002","24378801","","","","","","1","","","SMU.298","768" "SMu0270","287670","287452","219","ATGAATACAAAAATGATGGAACAATTTGAAACTATGGATGCTGAAACACTTTCACATGTAACTGGGGGCGGTCTTTACGATGGAGCTAATGGCTATGCTTACCGCGATTCCCAAGGTCACTGGGCTTATAAGGTAACAAAAACTCCAGCACAAGCTTTAACAGACGTTGTAGTAAATAGCTGGGCTTCAGGTGCAGCAAGTTTTGCCGCTTACGCTTAA","4.90","-2.54","7726","MNTKMMEQFETMDAETLSHVTGGGLYDGANGYAYRDSQGHWAYKVTKTPAQALTDVVVNSWASGAASFAAYA","287455","","bacteriocin peptide precursor","Extracellular","Single match in gapped BLAST to bovicin 255 peptide precursor from a Streptococcus sp (gi|11095283). Residues 1-59 are 52% similar to this sequence.SMu0270 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010133
Domain

Bacteriocin-type signal sequence
TIGR01847	$\"[9-23]T$	bacteriocin_sig: bacteriocin-type signal se

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-59 are 52% similar to a (PEPTIDE PRECURSOR BOVICIN) protein domain (PD273616) which is seen in Q9F656_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 15:47:30 2002","Mon Jan 14 15:44:52 2002","Thu Oct 24 11:37:18 2002","Mon Jan 14 15:44:52 2002","","Mon Jan 14 15:44:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0270 is paralogously related (blast p-value < 1e-3) to SMu0384, a hypothetical, SMu1738, a predicted bacteriocin, and to SMu1721, a hypothetical.","Mon Jan 14 16:03:31 2002","","No significant hits to the NCBI PDB database.","SMU.299c","","No significant hits to the Pfam 11.0 database","Mon Jan 14 15:44:52 2002","24378802","","Bekal-Si Ali S, Hurtubise Y, Lavoie MC, LaPointe G. Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes.Gene. 2002 Jan 23;283(1-2):125-31.PMID: 11867219 ","Whitford,M.F., McPherson,M.A., Forster,R.J. and Teather,R.M.Identification of bacteriocin-like inhibitors from rumenStreptococcus spp. and isolation and characterization of bovicin255Appl. Environ. Microbiol. 67 (2), 569-574 (2001)PUBMED 11157218","Sat Oct 26 16:37:40 2002","Sat Oct 26 16:37:40 2002","1","","","SMU.299c","" "SMu0271","288082","289224","1143","ATGACACATTCACCGATTCAATATCGTCTTATTAAGAAAGAAAAACACACTGGAGCACGTCTGGGAGAGATTATCACACCGCATGGAGTTTTTCCCACCCCTATGTTTATGCCAGTTGGAACACAGGCTACTGTCAAAACACAATCCCCAGAAGAATTAAAAGAAATGAAAGCAGGAATCATTTTGGCTAATACCTATCATCTCTGGTTACGGCCGGGAGATGACTTGGTTGCAAGAGCGGGAGGTCTACACAAATTCATGAATTGGGATCAGCCGATTTTAACCGATTCTGGTGGTTTTCAGGTTTATTCATTGGCTGAAAAACGCAATATTACTGAAGAAGGAGTCACTTTTAAAAATCATCTGAATGGAGCTAGAATGTTTTTGACCCCAGAAAAGGCCATTTCTATTCAAAATAATTTAGGTTCAGACATCATGATGTCCTTTGATGAATGCCCGCAGTTTTATCAGCCTTATGACTATGTCAAAGCTTCAATTGAACGAACCAGTCGTTGGGCAGAGCGAGGCCTCAAAGCTCACCGTCGGCCTCAGGATCAGGGACTTTTTGGCATTGTTCAGGGGGCAGGCTTTGAAGATTTGCGGCGTCAGTCAACAGCTGATCTGGTTTCAATGGATTTTCCGGGCTATTCCATCGGCGGTCTTGCTGTTGGGGAATCGCATGAAGAAATGAATGCCGTTCTTGACTTTACAACACCTTTATTACCAGAAAATAAACCTCGCTATCTCATGGGAGTTGGTGCACCGGACAGTCTAATTGATGGGGTTATTCGTGGCGTTGATATGTTTGATTGTGTCTTGCCGACTCGGATTGCTCGAAATGGAACCTGTATGACCTCAAGGGGACGCTTGGTTGTCAAAAATGCTCAGTATGCAGAAGACTTTACGCCGCTGGATCATGATTGTGATTGTTACACTTGTCAAAATTATACACGCGCTTATATTCGCCATCTGATTAAAGCAGATGAGACCTTTGGACTTCGCTTGACCAGTTATCATAACCTTTATTTCTTACTAAATCTTATGGAGAAAATTCGTCAAGCCATTATGGATGATAATATTTTAGAATTTCGTGAGGACTTTATTGAAAAGTACGGCTATGGACGCTCAGAGAGGAATTTTTAA","6.60","-2.61","43207","MTHSPIQYRLIKKEKHTGARLGEIITPHGVFPTPMFMPVGTQATVKTQSPEELKEMKAGIILANTYHLWLRPGDDLVARAGGLHKFMNWDQPILTDSGGFQVYSLAEKRNITEEGVTFKNHLNGARMFLTPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKASIERTSRWAERGLKAHRRPQDQGLFGIVQGAGFEDLRRQSTADLVSMDFPGYSIGGLAVGESHEEMNAVLDFTTPLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSRGRLVVKNAQYAEDFTPLDHDCDCYTCQNYTRAYIRHLIKADETFGLRLTSYHNLYFLLNLMEKIRQAIMDDNILEFREDFIEKYGYGRSERNF","289221","","tRNA-guanine transglycosylase; queuine tRNA-ribosyltransferase","Cytoplasm","Matches in gapped BLAST to tRNA-guanine transglycosylases, e.g. residues 1-380 are 89% similar to the enzyme from S.pyogenes (gi15674403) and 90% similar to the enzyme from S.pneumoniae ( gi15903910).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0396 (0.0).","

InterPro
IPR002616
Family

Queuine/other tRNA-ribosyltransferase
G3DSA:3.20.20.105	$\"[8-376]T$	tRNA_ribo_trans
PTHR11962	$\"[24-380]T$	tRNA_ribo_trans
PF01702	$\"[132-369]T$	TGT
TIGR00449	$\"[8-376]T$	tgt_general

InterPro
IPR004803
Family

Queuine tRNA-ribosyltransferase
TIGR00430	$\"[8-376]T$	Q_tRNA_tgt

noIPR
unintegrated

unintegrated
SSF51713	$\"[3-372]T$	SSF51713

","BeTs to 13 clades of COG0343COG name: Queuine/archaeosine tRNA-ribosyltransferaseFunctional Class: JThe phylogenetic pattern of COG0343 is AmTk-qvceb-huj--o-inxNumber of proteins in this genome belonging to this COG is 1","***** IPB002616 (Queuine tRNA-ribosyltransferase) with a combined E-value of 6.4e-119. IPB002616A 31-41 IPB002616B 64-105 IPB002616C 129-154 IPB002616D 188-220 IPB002616E 241-281 IPB002616F 308-324","Residues 132-369 are 85% similar to a (TRANSFERASE TRNA-RIBOSYLTRANSFERASE) protein domain (PD004261) which is seen in TGT_LACLA.Residues 20-102 are 89% similar to a (TRANSFERASE TRNA-RIBOSYLTRANSFERASE) protein domain (PD004830) which is seen in TGT_LACLA.Residues 19-131 are 58% similar to a (QUEUINE TRANSFERASE) protein domain (PD348167) which is seen in Q9JVA4_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 16:01:35 2002","Mon Jan 14 15:52:31 2002","Tue Jul 25 10:45:19 2006","Tue Jul 25 10:45:19 2006","Mon Jan 14 15:52:31 2002","Mon Jan 14 15:52:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0271 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 16:01:35 2002","Tue Jul 25 10:45:19 2006","pdb1F3EA Chain A, A New Target For Shigellosis: Rational Desi... 377 2e-105pdb1EFZA Chain A, Mutagenesis And Crystallographic Studies Of... 376 4e-105pdb1WKE Trna-Guanine Transglycosylase 374 1e-104","SMU.300","","Residues 132 to 369 (E-value = 1.2e-142) place SMu0271 in the TGT family which is described as Queuine tRNA-ribosyltransferase (PF01702)","Mon Jan 14 15:52:31 2002","24378803","","","Nonekowski ST, Kung FL, Garcia GA.The E. coli tRNA-guanine transglycosylase can recognize and modify DNA.J Biol Chem. 2001 Dec 21 [epub ahead of print]PMID: 11751936Romier C, Reuter K, Suck D, Ficner R.Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange.EMBO J. 1996 Jun 3;15(11):2850-7.PMID: 8654383 ","","Mon Jan 14 16:01:35 2002","1","","","SMU.300","51" "SMu0272","289224","289787","564","ATGGATGAAGAGCAGTTAAAGACATTACTGCTGGCAAATGAACCGATTTCTCGTATTTTAACCATTATTCGAGATCTTAAACTTTCGGATGCTTGGTTGTGTGCGGGCACACTTCGCAATTTTATTTGGAATTATTTAAGTGGGAAACCAGCCTTTGATAAGGAGACGGATATCGATGTTGTCTTTTTTGATCAGACGATTTCTTATGAAAAGACTTTGAGGATTGAGAAGGAGTTACAGGCAGCTTATCCTGCTTATCAATGGGAGCTCAAAAATCAAATTTATATGCATGTTCACAGTCCAAACACAGAGCCTTATCATAATTCTTGCGATGCTATTGCAAAATATCCAGAAAAGTGCACTGCCCTCGCTGCTAGAATAAATGACAAAGGGAAATTGGAGCTCTTCCTTCCCTATGGTTTAGAGGATATTGTTCAATTTAAAGTTGCCCCCACACCACATTTTTTAGCAGATGAGGAGAGAATGCGGGTTTACCAGCAACGTCTTCTGAAAAAGCATTGGCAAAATAAATGGCCACAATTACAGTTTTTAAAGGGAGATTAA","6.70","-0.94","22019","MDEEQLKTLLLANEPISRILTIIRDLKLSDAWLCAGTLRNFIWNYLSGKPAFDKETDIDVVFFDQTISYEKTLRIEKELQAAYPAYQWELKNQIYMHVHSPNTEPYHNSCDAIAKYPEKCTALAARINDKGKLELFLPYGLEDIVQFKVAPTPHFLADEERMRVYQQRLLKKHWQNKWPQLQFLKGD","289784","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 2-183 are 56% similar to gi|15902283 from S.pneumoniae. Residues 9-185 are 31% similar to gi|15673070 from L.lactis lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0089 (1e-55).","

InterPro
IPR009267
Family

Protein of unknown function DUF925, bacterial
PF06042	$\"[20-185]T$	DUF925

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 10-182 are 30% similar to a (PROTEOME COMPLETE VCA0380 YKJH) protein domain (PD358197) which is seen in Q9KMH4_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 16:07:05 2002","Mon Jan 14 16:07:05 2002","Mon Jan 14 16:07:05 2002","Mon Jan 14 16:07:05 2002","","Mon Jan 14 16:07:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0272 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 16:07:05 2002","","No significant hits to the NCBI PDB database.","SMU.301","","Residues 20 to 185 (E-value = 2.2e-105) place SMu0272 in the DUF925 family which is described as Bacterial protein of unknown function (DUF925) (PF06042)","Mon Jan 14 16:07:05 2002","24378804","","","","","","1","","","SMU.301","748" "SMu0273","290214","291227","1014","ATGTTAGGATTGCTTGCAGTTGTATTGTTTATTTTGTTAGTGGTTTCTATTTATCATGAGGCACGAAGTTTACTCAATCCCATTCTTCTTATCGTCTTCTTGATGGTAAGCTATTTGGCTATCATTGAATTTCTCTATAGTCATGGTTATTATACGGCTTATGGCGTTTTCCTGCTTCTTTTAATTTCGACTCCTCTTATCATATTTTTGGGTGGTCTCTTTTTAGTCTATAACGGGATTATTCTGTTACATAAAGAAGGTTTCTCGAAGATTAACCTTTTATCGCTTTGTTTAGGGCTAATGATTACTAGCTTCTTTTTATTCATGGTAATCCGAATTCACCATTCGACTCATTTGTTATTCAATCGTTTTATTGCTTCTTTGTATGCCTTGTTAAGCGCTTCTTTTCTTATTTTCAGTGTTGCCTTTATAGCTTTTATGCTGTATTCGATTCTTTATCTGATTATTCCTAAAAACAAGCATTATGATTATATTATTATTCATGGTGCAGGTCTTTTGCATGGCAATCAAGTGACTCCCTTATTAAAGCGCAGGATTGATAAGGCTTTAGAAGCCTTTAGACAATCGAAAAACTCGCAAGTCAAATTGATTGCCAGTGGCGGTTTAGGTTCTGGGGAAACCATTTCTGAAGCAGCGGCAATTGCCAATTATATTCGAAAACAGGCAAGTGATATTCCAAATGATAGGCTTCTCTTGGAAGAACAATCGCATTCGACCTATGAAAATCTTCTCTTTTCCAAGCAGTTAGCAGAAAAAGAAATGAAAAAACCGCGTTTTCTTTTTGTAACTAATGCTTATCATGTCTTTCGAACCAGTGTTTATGCACGCCGATTGCATATGGCTGGAGATGGCTTGGGTTGTTCAACAGCCGCCTATTATATTCCCAGTGCTTTTATTCGTGAATTTATTGCTATTGTTGTTTATTTGAAGTGGTTATTCATTATTGTTTATGCCTGGTTCATTATCGCTTTGATTTATTCTTTTTTTAGATAA","10.30","13.78","38385","MLGLLAVVLFILLVVSIYHEARSLLNPILLIVFLMVSYLAIIEFLYSHGYYTAYGVFLLLLISTPLIIFLGGLFLVYNGIILLHKEGFSKINLLSLCLGLMITSFFLFMVIRIHHSTHLLFNRFIASLYALLSASFLIFSVAFIAFMLYSILYLIIPKNKHYDYIIIHGAGLLHGNQVTPLLKRRIDKALEAFRQSKNSQVKLIASGGLGSGETISEAAAIANYIRKQASDIPNDRLLLEEQSHSTYENLLFSKQLAEKEMKKPRFLFVTNAYHVFRTSVYARRLHMAGDGLGCSTAAYYIPSAFIREFIAIVVYLKWLFIIVYAWFIIALIYSFFR","291224","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 20-335 are 30% similar to gi|16803044 from L.monocytogenes. Residues 20-333 are 29% similar to gi|16800072 from L.inocua.SMu0273 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003848
Domain

Protein of unknown function DUF218
PF02698	$\"[161-312]T$	DUF218

","BeTs to 4 clades of COG1434COG name: Uncharacterized ACRFunctional Class:� SThe phylogenetic pattern of COG1434 is -----qvcE--h---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 165-313 are 42% similar to a (COMPLETE PROTEOME MEMBRANE TRANSMEMBRANE) protein domain (PD096322) which is seen in O69207_ACTPA.Residues 173-277 are 28% similar to a (PROTEOME COMPLETE VCA0595) protein domain (PD319472) which is seen in Q9KLZ5_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 16:18:10 2002","Mon Jan 14 16:18:10 2002","Mon Jan 14 16:18:10 2002","Mon Jan 14 16:18:10 2002","","Mon Jan 14 16:18:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0273 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 16:18:10 2002","","No significant hits to the NCBI PDB database.","SMU.302","","Residues 92 to 318 (E-value = 5.3e-05) place SMu0273 in the DUF218 family which is described as Uncharacterized ACR, COG1434 (PF02698)","Mon Jan 14 16:18:10 2002","24378805","","","","","","1","","","SMU.302","" "SMu0274","291304","292080","777","ATGAAACTAACCACACTTGGTTGCTGGGGAGCCTATCCCTATAAAGATGAAGGAACAACCTCCTATCTCTTGACAGGAGAAGACGGTTTTCAGCTCTTAATTGATTGTGGTAGCCGTGCACTCAATGAACTCGAAAAAGAAATTAGCCCGCTAGATTTAGATGCAGTCATTATTTCTCACTATCATCCAGACCATGTCGCTGACTTGGGCGTTTTGCGTCATTATTTTCAGCTTTATCCTAAACATCTTTGGACGCCCAAAGTTTTACCGATTTACGGTCATGACCAAGATACTTATGAGTTTTCAAAGTTGACACTTGATGGTGTTTCTGAAGGCAGAGCTTATAATGTCAATGGTCTTGAGCAAATTGGACCTTTTGACATTACTTTTATTAAGACAGTACATCCTGTTGTTTGCTATGCCATACGTATTGTGGAGCGTACAACTGGTCAAATTTTTGTTTTCACAGGTGATACGGGTTATTTTGAGGATTTAGATAAATTTGCCGCAGGCGCGGACCTCTTTTTAGCAGATGTTTACCTTTACGAAGGCAATGAAAACCACATCGCTCATTTGACGACCAAAGAAGCTGGACAAATCGCTAGCGCGGCTAAGGTAAAACGTCTAGTCTTGACCCATATGCCACCAGTACCGCCAGCAGGCATTGATCCAGACAACCATCTAGAAATCCTAAGAAGCCAGACTGAGGCATACTCCAATGGCATCCCTGTGGAATTGGCTACACCTCACAAATCATGGCAAATCGGTAACTGCTGA","5.10","-12.29","28750","MKLTTLGCWGAYPYKDEGTTSYLLTGEDGFQLLIDCGSRALNELEKEISPLDLDAVIISHYHPDHVADLGVLRHYFQLYPKHLWTPKVLPIYGHDQDTYEFSKLTLDGVSEGRAYNVNGLEQIGPFDITFIKTVHPVVCYAIRIVERTTGQIFVFTGDTGYFEDLDKFAAGADLFLADVYLYEGNENHIAHLTTKEAGQIASAAKVKRLVLTHMPPVPPAGIDPDNHLEILRSQTEAYSNGIPVELATPHKSWQIGNC","292077","","conserved hypothetical protein","Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-257 are 78% similar to gi|15674406 from S.pyogenes. Residues 1-255 are 57% similar to gi|15672701 from L.lactis lactis.See also SMu1377, previously published in GenBank.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0399 (1e-116).","

InterPro
IPR001279
Domain

Beta-lactamase-like
PF00753	$\"[18-213]T$	Lactamase_B

noIPR
unintegrated

unintegrated
G3DSA:3.60.15.10	$\"[1-218]T$	G3DSA:3.60.15.10
PTHR12553	$\"[31-216]T$	PTHR12553
PTHR12553:SF7	$\"[31-216]T$	PTHR12553:SF7
SSF56281	$\"[1-241]T$	SSF56281

","BeTs to 7 clades of COG1234COG name: Metal-dependent hydrolases of the beta-lactamase superfamily IIIFunctional Class:� RThe phylogenetic pattern of COG1234 is Amtky-vceBR-----oLin-Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 18-75 are 68% similar to a (COMPLETE PROTEOME HYDROLASE FACTOR POLYADENYLATION) protein domain (PD000482) which is seen in Q9CHL0_LACLA.Residues 154-215 are 36% similar to a (PROTEOME COMPLETE BH3002 VNG1503C) protein domain (PD220813) which is seen in Q9K8K4_BACHD.Residues 150-215 are 56% similar to a (PROTEOME COMPLETE ELAC2 CHROMOSOME) protein domain (PD352433) which is seen in Q9CHL0_LACLA.Residues 1-94 are 39% similar to a (PROTEOME COMPLETE BH3002) protein domain (PD352319) which is seen in Q9K8K4_BACHD.Residues 100-146 are 74% similar to a (PROTEOME COMPLETE BH3002 YHCG) protein domain (PD405992) which is seen in Q9CHL0_LACLA.Residues 24-214 are 27% similar to a (PROTEOME COMPLETE METAL DEPENDENT) protein domain (PD329287) which is seen in O26845_METTH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 16:23:03 2002","Mon Jan 14 16:23:03 2002","Mon Jan 14 16:25:09 2002","Mon Jan 14 16:22:20 2002","","Mon Jan 14 16:22:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0274 is paralogously related (blast p-value < 1e-3) to SMu1341, a conserved hypothetical protein, and SMu1377, a predicted CovX protein.","Mon Jan 14 16:26:03 2002","","No significant hits to the NCBI PDB database.","SMU.303","","Residues 18 to 213 (E-value = 2.3e-16) place SMu0274 in the Lactamase_B family which is described as Metallo-beta-lactamase superfamily (PF00753)","Mon Jan 14 16:22:20 2002","24378806","","","","","","1","","","SMU.303","" "SMu0275","292080","292550","471","ATGGTAGGTTTGACTCAGGCAGAAAAAGAGTTTTTTATGGGAGAAGCTCTCAAAGAAGCTCAGCTATCACTTCAAAAAGAAGAGATTCCTATTGGCTGTGTTATCGTTAAGGACGGTCAAATCATTGGGTGTGGTCATAATGCGCGTGAAGAGGAAAATCTTGCCATCATGCATGCCGAAATTATGGCTATCAATCAAGCAAATAGAACACAAGAAAGTTGGCGTCTGCTGGATTGTACGCTTTTTGTCACCATTGAGCCTTGCATTATGTGCAGCGGAGCCATTGGTTTAGCACGTATTCCGCAGGTCATTTACGGTGCCAAAAATGCTAAATTTGGTGGGGCTGGTTCCTTATATGATATCCTAACTGATGAGCGGCTCAATCATCGTGTAGAAGTAGAGAGGGGAATTCTGGAAAAAGAATGTGCTCAAATGATGCAGAGTTTTTTTAGATACAGGAGAACAAAATGA","5.80","-2.56","17523","MVGLTQAEKEFFMGEALKEAQLSLQKEEIPIGCVIVKDGQIIGCGHNAREEENLAIMHAEIMAINQANRTQESWRLLDCTLFVTIEPCIMCSGAIGLARIPQVIYGAKNAKFGGAGSLYDILTDERLNHRVEVERGILEKECAQMMQSFFRYRRTK","292547","","cytidine/ deoxycytidylate deaminase","Cytoplasm, Extracellular","Matches in gapped BLAST to cytidine/deoxycytidylate deaminases and to hypotheticals. Residues 5-156 are 76% similar to gi|15899968 from S.pneumoniae. Residues 2-156 are 64% similar to gi|15672703 from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0400 (3e-64).","

InterPro
IPR002125
Domain

CMP/dCMP deaminase, zinc-binding
PF00383	$\"[6-107]T$	dCMP_cyt_deam_1
PS00903	$\"[58-95]T$	CYT_DCMP_DEAMINASES

noIPR
unintegrated

unintegrated
G3DSA:3.40.140.10	$\"[7-154]T$	G3DSA:3.40.140.10
PTHR11079	$\"[8-156]T$	PTHR11079
PTHR11079:SF9	$\"[8-156]T$	PTHR11079:SF9
SSF53927	$\"[5-156]T$	SSF53927

","BeTs to 8 clades of COG0590COG name: Cytosine deaminase-related enzymesFunctional Class: FThe phylogenetic pattern of COG0590 is ----Yq-CeBRh------inxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 33-104 are 38% similar to a (DEAMINASE COMPLETE PROTEOME REDUCTASE) protein domain (PD001793) which is seen in FCA1_CANAL.Residues 117-154 are 71% similar to a (PROTEOME COMPLETE DEAMINASE) protein domain (PD330294) which is seen in Q9CHK8_LACLA.Residues 9-47 are 66% similar to a (& PROTEOME COMPLETE HYDROLASE) protein domain (PD346227) which is seen in Q9CHK8_LACLA.Residues 7-141 are 31% similar to a (DOMAIN OF UNKNO N) protein domain (PD085084) which is seen in O59834_SCHPO.Residues 55-134 are 42% similar to a (PROTEOME COMPLETE DEAMINASE HYDROLASE) protein domain (PD404873) which is seen in Q9KTN7_VIBCH.Residues 111-154 are 50% similar to a (PROTEOME COMPLETE DEAMINASE HYDROLASE) protein domain (PD257526) which is seen in Q9KGM5_BACHD.Residues 58-151 are 31% similar to a (CG5292) protein domain (PD395604) which is seen in Q9VEM0_DROME.Residues 109-154 are 54% similar to a (PROTEOME COMPLETE ZINC HYDROLASE) protein domain (PD345667) which is seen in YFHC_ECOLI.Residues 55-114 are 70% similar to a (4933426M09RIK DEAMINASE-BIFUNCTIONAL) protein domain (PD399970) which is seen in Q9CHK8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:40:43 2002","Thu Oct 10 10:43:23 2002","Thu Oct 24 17:05:34 2002","Tue Oct 8 08:40:43 2002","","Mon Jan 14 16:32:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0275 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 08:40:43 2002","","No significant hits to the NCBI PDB database.","SMU.304","","Residues 7 to 107 (E-value = 3.9e-31) place SMu0275 in the dCMP_cyt_deam family which is described as Cytidine and deoxycytidylate deaminase zinc-binding region (PF00383)","Mon Jan 14 16:32:23 2002","24378807","","","","","","1","","","SMU.304","643" "SMu0276","292547","293110","564","ATGAATACAATCACCAAGCCACAGGAATGGCTATTATCAGCTTTTTTGTTTGCTTTAACATTACTCTTTGTTGGTCTGCTAGTTTTGAATTTAGATTTTCAAGCTTGGGCTTTTGAACGTCATCAAAACCAATTAAGCTGGTATATTCGTCCTATTTTAATCCTTCCCATCTTGTTTTTTGCCTATCATAGACGAATCATAGGGGTATCGGTTAGCATCTTGGCTCTTTTTACAAGCATGATTTGGTTTCCCGTGCCACAATCAACCCCACCTTTAGTCAAGGAGTTTTTAACCTATGAGAAGGAATTTTTACAAGCAGGCTTGACAGCTAAGAATGTGCTCTTTGCCTTTTTGGTTATTAGTTTTTTTATCGTCATTGTTAGGGCAACTTGGCTACATAGTTGGAAGTTAGTTGGTTTAATTTTGATTATCACAGCCCTTTCAAAAATTATTTGGTCTTATATGGACAGTGGACAGGCGGGCTTGACTATTGTCGTCCCAGCCCTAGTTGGTTTGATGATTTGCCTCTTAGCTCTTGCTTTTTGGCAAAAGAAAAAGTCTTAA","10.60","7.66","21401","MNTITKPQEWLLSAFLFALTLLFVGLLVLNLDFQAWAFERHQNQLSWYIRPILILPILFFAYHRRIIGVSVSILALFTSMIWFPVPQSTPPLVKEFLTYEKEFLQAGLTAKNVLFAFLVISFFIVIVRATWLHSWKLVGLILIITALSKIIWSYMDSGQAGLTIVVPALVGLMICLLALAFWQKKKS","293107","","conserved hypothetical protein","Membrane, Cytoplasm","This sequence corresponds to the previously published gi|4928280, gi|9802002, gi|12082663, and to a lesser degree gi|11346171 and gi|5918764, variously named MutT or unknown.Otherwise, nearest neighbor is 23019994 from Clostridium thermocellum.SMu0276 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-37]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[44-62]?$ $\"[67-85]?$ $\"[113-133]?$ $\"[135-153]?$ $\"[159-181]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-187 are 82% similar to a (DOMAIN OF UNKNO N) protein domain (PD308127) which is seen in Q9X669_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 16:41:13 2002","Thu Oct 31 09:46:24 2002","Thu Oct 31 09:46:24 2002","Mon Jan 14 16:39:59 2002","","Mon Jan 14 16:39:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0276 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 16:41:13 2002","","No significant hits to the NCBI PDB database.","SMU.305","","No significant hits to the Pfam 11.0 database","Mon Jan 14 16:39:59 2002","24378808",""," Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. and Hamilton,I.R. TITLE Identification of the operon for the sorbitol (Glucitol) Phosphoenolpyruvate:Sugar phosphotransferase system in Streptococcus mutans JOURNAL Infect. Immun. 68 (2), 925-930 (2000) PubMed: 20107103Qi,F., Chen,P. and Caufield,P.W. TITLE Purification of mutacin III from group III streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes JOURNAL Appl. Environ. Microbiol. 65 (9), 3880-3887 (1999) PubMed: 99402724","","Thu Oct 31 09:46:24 2002","","1","","","SMU.305","" "SMu0277","293667","295016","1350","ATGACACACATTAAATTCGATTATTCAAAAGTATTGGGGAAATTCCTTGCTTCACATGAATTGGATTATATTCAAATGCAAGTAACAGCAGCGGATGAGGCTTTGCGTAAAGGAACTGGACCGGGTGCTGAAATGACGGGCTGGCTGAATTTACCTCAGAACTATGATAAAGAAGAATTTGCTCGTATTAAAAAGGCTGCTGAAAAAATCAAATCTGATAGTGAAGTTTTGGTTGTTATCGGTATTGGCGGTTCTTATCTGGGGGCACGTGCAGCGATTGATTTTTTGAACAGTTCTTTTGTCAATCTTGAAAATAAGGAAGAACGCAAAGCACCGCAAATTCTTTATGCCGGAAATTCGATTTCTTCAAATTACCTTGCGGATCTTGTTGATTATGTGGCTGATAAGGATTTTTCGGTTAATGTTATTTCTAAATCAGGAACAACTACTGAACCTGCCATAGCTTTTCGCGTTTTCAAAGATCTTCTAGTTAAAAAGTATGGTCAAGAAGAAGCTAATCAACGTATTTATGCGACAACTGATCGTGTTAAAGGAGCCGTTAAAGTAGAAGCGGATGCCAATGGTTGGGAAACTTTTGTCGTTCCAGATAGTGTTGGTGGACGTTTTACGGTTTTAACAGCTGTTGGTTTATTGCCAATTGCAGCTTCAGGAGCAGATTTGGATCAGTTGATGGCTGGGGCAGAAGCAGCTCGTCAAGACTATTCGTCTGCTGAATTATCAGAAAATGAAGCTTATCAATATGCGGCTATTCGTAATATTCTTTACCGTAAAGGTTATGTGACAGAAGTTTTGGCTAACTATGAACCATCCCTTCAATACTTTAGTGAATGGTGGAAACAATTAGCCGGTGAATCAGAAGGTAAAGACCAAAAAGGCATTTACCCAACATCAGCTAACTTTTCAACAGATTTGCATTCTCTTGGACAATTTATCCAAGAGGGCAATCGCAATTTATTTGAAACGGTTATCCGTGTTGAAAAAGCACGTAAGAATATCCTTGTTCCAGAAGCAGCAGAAGATCTTGACGGTCTTGCCTATCTTCAAGGCAAAGATGTTGATTTTGTTAATAAGAAGGCTACCGATGGCGTACTGTTAGCTCATACAGATGGGGGTGTCCCAAATACCTTCTTGACTATTCCTGAGCAGGATGAATTTACATTAGGTTATGTGATTTACTTCTTCGAATTGGCTATTGGACTTTCTGGTTACCTAAATGGTGTTAACCCATTTGACCAACCGGGTGTTGAAGCCTACAAGAAAAATATGTTTGCTCTTCTTGGCAAACCAGGATTCGAAGAACTTGGTGCTGAGTTAAACGCACGTCTTTAG","4.70","-16.99","49410","MTHIKFDYSKVLGKFLASHELDYIQMQVTAADEALRKGTGPGAEMTGWLNLPQNYDKEEFARIKKAAEKIKSDSEVLVVIGIGGSYLGARAAIDFLNSSFVNLENKEERKAPQILYAGNSISSNYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFKDLLVKKYGQEEANQRIYATTDRVKGAVKVEADANGWETFVVPDSVGGRFTVLTAVGLLPIAASGADLDQLMAGAEAARQDYSSAELSENEAYQYAAIRNILYRKGYVTEVLANYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGNRNLFETVIRVEKARKNILVPEAAEDLDGLAYLQGKDVDFVNKKATDGVLLAHTDGGVPNTFLTIPEQDEFTLGYVIYFFELAIGLSGYLNGVNPFDQPGVEAYKKNMFALLGKPGFEELGAELNARL","295013","","glucose-6-phosphate isomerase","Cytoplasm","This sequence corresponds to the previously published gi|4928281 and gi|11356484 in GenBank, a predicted glucose-6-phosphate isomerase. Also, residues 1-449 are 82% similar to the enzyme from S.pneumoniae (gi|15903923).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0402 (0.0).","

InterPro
IPR001672
Family

Phosphoglucose isomerase (PGI)
PR00662	$\"[77-96]T$ $\"[199-217]T$ $\"[274-295]T$ $\"[377-395]T$ $\"[395-409]T$ $\"[409-422]T$	G6PISOMERASE
PTHR11469	$\"[42-440]T$	G6P_Isomerase
PF00342	$\"[7-446]T$	PGI
PS00174	$\"[409-426]T$	P_GLUCOSE_ISOMERASE_2
PS00765	$\"[203-216]T$	P_GLUCOSE_ISOMERASE_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10490	$\"[191-418]T$	G3DSA:3.40.50.10490
SSF53697	$\"[1-449]T$	SSF53697

","BeTs to 12 clades of COG0166COG name: Glucose-6-phosphate isomeraseFunctional Class:� GThe phylogenetic pattern of COG0166 is -m--yqvcebrhujgpolin-Number of proteins in this genome belonging to this COG is 1","***** IPB001672 (Phosphoglucose isomerase (PGI)) with a combined E-value of 6.2e-17. IPB001672B 61-97 IPB001672C 120-162 IPB001672D 177-212 IPB001672E 255-301 IPB001672H 394-426","Residues 1-40 are identical to a (ISOMERASE GLUCOSE-6-PHOSPHATE) protein domain (PD232472) which is seen in Q9X670_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 16:45:53 2002","Mon Jan 14 16:42:21 2002","Mon Jan 14 16:53:17 2002","Mon Jan 14 16:42:21 2002","Mon Jan 14 16:42:21 2002","Mon Jan 14 16:42:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0277 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 16:45:53 2002","Mon Jan 14 16:42:21 2002","pdb|1C7Q|A Chain A, The Crystal Structure Of Phosphoglucose Iso... 546 2e-156","SMU.307","","Residues 7 to 446 (E-value = 1.3e-153) place SMu0277 in the PGI family which is described as Phosphoglucose isomerase (PF00342)","Mon Jan 14 16:42:21 2002","24378809","","Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 20107103","","Mon Jan 14 16:45:53 2002","","1","","","SMU.307","52" "SMu0278","295182","295982","801","ATGGCTGATTGGTTAAATATTGCTGGCAAAACAGTAATTGTAACAGGAGCTTCCTCAGGCATCGGAAAAGCTATTGTGGATGAATTACTGAGCTTGAAGGTAAAAGTCGCTAATTTTGATCTCACGGATAATGGAGAAAAGCATGAAAATCTCTTGTTCCAGAAAGTGGATGTGACATCCCGTGAGCAAGTAGAAGCTTCTGTTGCAGCTGTTGTTGAACATTTTGGAACAGTTGATGCTGTTGTCAATAATGCAGGCATCAATATTCCACGTCTCTTAGTTGATCCTAAGGATCCTCATGGGCAATACGAGCTTGATGATGCAACTTTTGAAAAGATTACCATGATTAATCAGAAAGGCCTCTATTTGGTTAGTCAAGCGGTAGGGCGCCTTTTAGTGGCAAAGAAAAAAGGAGTTATTATCAATATGGCTTCGGAAGCTGGTTTAGAAGGTTCTGAAGGACAAAGTGCTTATGCGGGAACCAAGGCTGCTGTTTATAGTTATACACGATCATGGGCAAAGGAACTTGGCAAATACGGTGTTCGAGTTGTTGGTATTGCTCCGGGAATCATGGAAGCAACAGGTCTGCGGACGCTTGCTTATGAAGAGGCACTTGGCTATACTAGAGGAAAGACAGTTGAGGAAATTCGTGCAGGTTACGCATCAACAACGACAACACCACTGGGACGCAGTGGGAAATTAAGTGAAGTTGCAGATTTGGTAGCTTATTACATTTCGGACCGTTCAAGTTATATCACAGGTATCACAACCAATGTTGCCGGAGGTAAAACGCGCGGTTAA","6.80","-0.27","28281","MADWLNIAGKTVIVTGASSGIGKAIVDELLSLKVKVANFDLTDNGEKHENLLFQKVDVTSREQVEASVAAVVEHFGTVDAVVNNAGINIPRLLVDPKDPHGQYELDDATFEKITMINQKGLYLVSQAVGRLLVAKKKGVIINMASEAGLEGSEGQSAYAGTKAAVYSYTRSWAKELGKYGVRVVGIAPGIMEATGLRTLAYEEALGYTRGKTVEEIRAGYASTTTTPLGRSGKLSEVADLVAYYISDRSSYITGITTNVAGGKTRG","295979","For other 'srl' genes see SMu0280 (srlM); SMu0281 (srlA); SMu0282 (srlE); SMu0283 (srlB) and SMu1207 (srlD).","sorbitol-6-phosphate 2-dehydrogenase","Cytoplasm","This sequence corresponds to the previously published gi|4928282 and gi|11250508 in GenBank. Additionally, residues 1-266 are 61% similar to the enzyme from L. casei (gi|6690419).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0348 (2e-23).","

InterPro
IPR002198
Family

Short-chain dehydrogenase/reductase SDR
PR00080	$\"[76-87]T$ $\"[138-146]T$ $\"[158-177]T$	SDRFAMILY
PTHR19410	$\"[5-197]T$ $\"[214-261]T$	ADH_short_C2
PF00106	$\"[10-177]T$	adh_short
PS00061	$\"[145-173]?$	ADH_SHORT

InterPro
IPR002347
Family

Glucose/ribitol dehydrogenase
PR00081	$\"[11-28]T$ $\"[76-87]T$ $\"[132-148]T$ $\"[158-177]T$ $\"[179-196]T$ $\"[227-247]T$	GDHRDH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-262]T$	G3DSA:3.40.50.720
PTHR19410:SF85	$\"[5-197]T$ $\"[214-261]T$	PTHR19410:SF85
SSF51735	$\"[8-263]T$	SSF51735

","BeTs to 11 clades of COG1028COG name: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)Functional Class: RThe phylogenetic pattern of COG1028 is a--KYQVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 4","***** IPB002198 (Short-chain dehydrogenase/reductase (SDR) superfamily) with a combined E-value of 1.2e-12. IPB002198 138-173","Residues 57-127 are 83% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME) protein domain (PD126102) which is seen in Q9X671_STRMU.Residues 182-262 are 80% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD000197) which is seen in Q9RGG6_LACCA.Residues 138-181 are identical to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD003795) which is seen in Q9X671_STRMU.Residues 2-44 are identical to a (OXIDOREDUCTASE DEHYDROGENASE) protein domain (PD405982) which is seen in Q9X671_STRMU.Residues 122-265 are 27% similar to a (OXIDOREDUCTASE PROTEOME COMPLETE LONG) protein domain (PD169769) which is seen in O59473_PYRHO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 10:52:10 2002","Mon Jan 14 16:59:18 2002","Mon Jan 14 17:05:04 2002","Tue Apr 9 14:42:06 2002","Mon Jan 14 16:59:18 2002","Mon Jan 14 16:59:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0278 is paralogously related (blast p-value < 1e-3) to SMu1207, a predicted acetoin reductase, SMu1586, a predicted 3-oxoacyl-acyl-carrier-protein, and to SMu0949 and SMu1340, oxidoreductases.","Mon Jan 14 17:08:01 2002","Mon Jan 14 16:59:18 2002","pdb|1I01|A Chain A, Crystal Structure Of Beta-Ketoacyl [acyl Ca... 123 3e-029pdb|1HDC|A Chain A, 3-Alpha, 20-Beta-Hydroxysteroid Dehydrogena... 104 1e-023pdb|1EDO|A Chain A, The X-Ray Structure Of Beta-Keto Acyl Carri... 104 2e-023","SMU.308","","Residues 12 to 263 (E-value = 2.7e-74) place SMu0278 in the adh_short family which is described as short chain dehydrogenase (PF00106)","Mon Jan 14 16:59:18 2002","24378810","","Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 10639465","Yebra,M.J., Veyrat,A., Santos,M.A. and Perez-Martinez,G.Genetics of L-sorbose transport and metabolism in LactobacilluscaseiJ. Bacteriol. 182 (1), 155-163 (2000)PubMed: 10613875","Tue Apr 9 14:42:06 2002","Tue Apr 9 14:42:06 2002","1","","","SMU.308","" "SMu0279","296004","297869","1866","GTGGCATTAGTTAATCGCTGGTATCATATTTTAGAAATATTAGTTGCTCAGCATAGTGTTTCTCTAGAAACTATGCGTAAAGAACTTAATGTCAGTATGAAAACGTTGCTGACAAGTATAGAGCAATTTAATGCTATTTTGGATGATGATATTCAAATCAGACAAGAAAATAATCTTTTGCTGTTAGACGTCTATGATTATGCTAGATTGGAAACAATTTTAGCGGGAAGTTTGCGCAAAGAGAGTGATTTTAATTCTTCAAATAAGCGAGCTTCTTATCTCATTAAACGTTTGATTCAAGCCACATCTCCCTTACTTATTGATGATTTGGCTGAGGAAATCGGTGTTAGTCGAACGACCATTAATAAGGATTTGAAGCATGTTAAGGATTTAGCAGTAGAATATCAATTGTGCATATTCGGCAAACCTAATCGTGGTTTGGAAATTATTGGTACGGAATTAAATCTACGGCTCTTTTATATTCATCATGTCTATTCTTATTTTGATTCAGCTACCTTAAAGAAAGAGACGCATGATTTTTTAGAAGAACTATATACTGCCTTTAAAATTCCTAGAAAAACGCAGGAGTTACTGACTAAAGCCATTTCGATAACAGTTGCTCGCATTCAACGGAAAAAACTTTTGCTTACTCCTATTGACTATTATGTTAACGGACTAGCTCAGTCAGCTATTATGGAGCAATTGCTTTATCATATTGAAGTGACTTATCAGATATCGCTCAGTCAGTATGAACAAGATTTCTTGAGTTTTCCTCTCAATACACAATATATTGACGCATTGACCTATCAATTGACTGATGTGCAGAGTTTGCAGAAGCTTTATCAAAGCTTTGTAAAGAAGGTTAAGGATACACTCTTGGTTAACTTTGATGAGCAACGTTTATTTGCTGAAATTCAAACACATTTAAAATTTCTTATCAATCGACTTATCTTTCATGTTCAGGCTAATGATATTTTCCATAGAGAAATTCAAAATAAGTATCCCTTGGCCTTTGAAATGGCAAAAGTCGCTGGTGATGATTTAAAAAATCATTTTGGCTGTCAGCTGGAATTGTCTGAAATGAGCTATTTAGCCCTTTATTTCGAAATGATTTTACATGAAAATGGAGCTATTTTTCAAAACAAAAAACGCCGAGTTGCCGTTGTTTGTACAACGGGACGCGGAACAGCACATATGATAAAGCGTCAATTAAAACGCGTACTTGGCCATGATATCGAAATCACTCAATATTCAGAAGAAAACTTTAATCCTGACACTAATGATAATTACTTTGCTGTCTTTACAACCATTCCTTTGAAATTAGGACAGATTAACTCGCCAGTTATTCAAATTAGAAATCTTTTTGATGATCAGTGGCTGCGTGAGGAATGGCAACGCGTTAATCATTATCATAGAAAAAATCTCAAAACAATCATTTTGACCTTTTCGAGATTGGTCAAAGCTGCTAGCTATCAAGATTATTTAGTGTATATGACACAGTCACTAGAAGCATTAAGGCTAGTGGATGATCATTTTGAAAAACGTATTTTAGATAGAGAAAAAGAACAATCTACTATATTTGGCAATGGTATTGCTTTTCCACATACTATCAATCAAACATTAGAAAAGATCGTTTTAATGGTAGGAGTTCTTGAGGAGCCCTACCATACAGATCATGAAAGTGTTGATCTTATCTTTTTAGTAGCTATTCCCAATAAAATTGCAACACAAACAGAGGCAGAACTTTTAGAATTGTATGATGATATTTTTCGAATTGCTAGCGATAAAGAGCTCAAAGAAGCTTTAGAAAGAGTGGAAAACAAAGCAGACTTTATTACATTTACCAGAGAAAAAGGAGTATTCTGA","6.40","-7.26","72548","MALVNRWYHILEILVAQHSVSLETMRKELNVSMKTLLTSIEQFNAILDDDIQIRQENNLLLLDVYDYARLETILAGSLRKESDFNSSNKRASYLIKRLIQATSPLLIDDLAEEIGVSRTTINKDLKHVKDLAVEYQLCIFGKPNRGLEIIGTELNLRLFYIHHVYSYFDSATLKKETHDFLEELYTAFKIPRKTQELLTKAISITVARIQRKKLLLTPIDYYVNGLAQSAIMEQLLYHIEVTYQISLSQYEQDFLSFPLNTQYIDALTYQLTDVQSLQKLYQSFVKKVKDTLLVNFDEQRLFAEIQTHLKFLINRLIFHVQANDIFHREIQNKYPLAFEMAKVAGDDLKNHFGCQLELSEMSYLALYFEMILHENGAIFQNKKRRVAVVCTTGRGTAHMIKRQLKRVLGHDIEITQYSEENFNPDTNDNYFAVFTTIPLKLGQINSPVIQIRNLFDDQWLREEWQRVNHYHRKNLKTIILTFSRLVKAASYQDYLVYMTQSLEALRLVDDHFEKRILDREKEQSTIFGNGIAFPHTINQTLEKIVLMVGVLEEPYHTDHESVDLIFLVAIPNKIATQTEAELLELYDDIFRIASDKELKEALERVENKADFITFTREKGVF","297866","","regulator of sorbitol operon","Cytoplasm","This sequence corresponds to the previously sequenced gi4928283 and gi11356487 in GenBank, predicted sorbitol operon regulators.zfurthermore, residues 13-615 are 22% similar to gi16802447 from L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1346 (5e-04).","

InterPro
IPR002178
Domain

Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PD001689	$\"[508-585]T$	O31644_BACSU_O31644;
G3DSA:3.40.930.10	$\"[486-614]T$	no description
PF00359	$\"[474-605]T$	PTS_EIIA_2
PS51094	$\"[473-618]T$	PTS_EIIA_TYPE_2

InterPro
IPR011608
Domain

PRD
PF00874	$\"[282-371]T$	PRD

InterPro
IPR013011
Domain

Phosphotransferase system, EIIB component, type 2
PS51099	$\"[384-472]T$	PTS_EIIB_TYPE_2

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[90-148]T$	HTH_11

noIPR
unintegrated

unintegrated
G3DSA:1.10.1790.10	$\"[280-368]T$	no description

","BeTs to 3 clades of COG1762COG name: Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)Functional Class: G,TThe phylogenetic pattern of COG1762 is --------EB-H--gPOLIN-Number of proteins in this genome belonging to this COG is 4","***** IPB002178 (phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) with a combined E-value of 3.5e-07. IPB002178 519-536","Residues 452-621 are identical to a (SORBITOL REGULATOR OPERON) protein domain (PD248203) which is seen in Q9X672_STRMU.Residues 326-451 are identical to a (REGULATOR PROTEOME COMPLETE) protein domain (PD024189) which is seen in Q9X672_STRMU.Residues 3-157 are 28% similar to a (PROTEOME COMPLETE YJDC REGULATION) protein domain (PD339335) which is seen in CELR_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 17:12:30 2002","Mon Jan 14 17:12:30 2002","Fri Mar 16 11:32:35 2007","Fri Mar 16 11:32:35 2007","Sun Jan 13 16:11:35 2002","Sun Jan 13 16:11:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0279 is paralogously related (blast p-value < 1e-3) to SMu1454 and SMu0260, both predicted transcriptional regulators, and to SMu0795, a predicted fructose-specific PTS system enzyme IIBC component.","Mon Jan 14 17:17:12 2002","","No significant hits to the NCBI PDB database.","SMU.309","","Residues 277 to 371 (E-value = 1.2e-18) place SMu0279 in the PRD family which is described as PRD domain (PF00874)","Sun Jan 13 16:11:35 2002","24378811","","Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 20107103Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 10639465","","Fri Mar 16 11:32:35 2007","","1","","","SMU.309","" "SMu0280","297869","298357","489","ATGAATTTTATGATTATTTTTGGTCTCTTTGCTTTAGCAGCCTATGCAGTTCAAATCATATTAGGCTTAAAGCAAATAAAACATTTTAATAGCATTTATAGGCAATTAAGGCGTCTAGGACGTGTAGCTATTGGACGTCGGTCTGGTAAGATCAGAGCTGGGACTATCGTTATGTTTGCTATTGATAAAGATGGTAAGGTTTTGGCTGCTAAAAAGATGCAGGGTATTACCATGGCTGCTCGTTTTAAAGATATGTCAGATTATATTGGACAGGACATCCATTATTTTGACAGCTATAATCCCCTCATTCGTAAGGAAAATAAGTTACTGCGCATTGCTATTGAAGATGCGAGAGCTGTTTTTCTAAAAACAGAGGCAGGTATTTATAAAGAGTCTCCCAAACAGACGCCATTACTTGATATTAGGTTACAGACTAAATTCTTATTATCACGTTTTAAGTTAAAAAAACGTCATGAAACTAAAATTTGA","11.20","19.71","18692","MNFMIIFGLFALAAYAVQIILGLKQIKHFNSIYRQLRRLGRVAIGRRSGKIRAGTIVMFAIDKDGKVLAAKKMQGITMAARFKDMSDYIGQDIHYFDSYNPLIRKENKLLRIAIEDARAVFLKTEAGIYKESPKQTPLLDIRLQTKFLLSRFKLKKRHETKI","298354","For other 'srl' genes see SMu0278 (srlD); SMu0281 (srlA); SMu0282 (srlE); SMu0283 (srlB) and SMu1207 (srlD).","sorbitol operon activator","Cytoplasm, Membrane","This sequence corresponds to the previously sequenced gi4928284 and gi11346172 in GenBank, predicted sorbitol operon activator.There are limited weak similarities in gapped BLAST, e.g. residues 1-114 are 29% similar to a GutM protein from P.multocida (gi15603832).SMu0280 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR009693
Family

Glucitol operon activator
PF06923	$\"[4-138]T$	GutM

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 11-81 are identical to a (ACTIVATOR OPERON REGULATION GLUCITOL) protein domain (PD031353) which is seen in Q9X673_STRMU.Residues 82-162 are 85% similar to a (SORBITOL ACTIVATOR OPERON) protein domain (PD274802) which is seen in Q9X673_STRMU.Residues 3-94 are 25% similar to a (PROTEOME BH0770 COMPLETE) protein domain (PD295018) which is seen in Q9KES9_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:33:07 2007","Tue Jan 15 15:35:39 2002","Fri Mar 16 11:33:07 2007","Tue Jan 15 15:35:39 2002","","Tue Jan 15 15:35:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0280 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 15 15:38:43 2002","","No significant hits to the NCBI PDB database.","SMU.310","","Residues 4 to 138 (E-value = 6.6e-85) place SMu0280 in the GutM family which is described as Glucitol operon activator protein (GutM) (PF06923)","Tue Jan 15 15:35:39 2002","24378812","","Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 20107103","","Fri Mar 16 11:33:07 2007","","1","","","SMU.310","" "SMu0281","298437","298979","543","ATGTCTTATATTACAAAATTTGCTGAAGGGTTCATGAAACTTTTCCAAGCTGGGGGCGACAATTTTGTAGGTTGGATGACCAGTATTGTTCCAGTAGTTCTGATGCTCTTAGTTGCAATGAATGCGCTGATTGCTCTGCTTGGAGAAGAAAAAGTTAATAAATTAGCCCGAATATCTGCTAAAAATCCGCTTAGTCGCTATATGATTCTGCCTTTTATCTCTGCCTTTATGCTTGGGAATCCAATGGCGATTAGTATGGGACGCTTTATGCCGGAGTATTACAAGCCAAGCTATATCGCTTCTCAAATGCAGTTTTGTCATACTTCAAACGGTGTCTTTCCACACATCAATCCTGGTGAGTTGTTTGTATGGATGGGGATTGCATCAGGGATAAAAACACTTGGTTTAAGTCAGATGGATCTAGCTATTCGTTATCTGCTAGTAGGGCTTTTAATGAATTTTGTTTCTGGCTGGGTGACTGATTTCACAACCGCTTGGGTATGCAAACAACAAGGAATTACATTGAGCAAAACCCTTGATTAA","9.80","4.37","20012","MSYITKFAEGFMKLFQAGGDNFVGWMTSIVPVVLMLLVAMNALIALLGEEKVNKLARISAKNPLSRYMILPFISAFMLGNPMAISMGRFMPEYYKPSYIASQMQFCHTSNGVFPHINPGELFVWMGIASGIKTLGLSQMDLAIRYLLVGLLMNFVSGWVTDFTTAWVCKQQGITLSKTLD","298976","For other 'srl' genes see SMu0278 (srlD); SMu0280 (srlM); SMu0282 (srlE); SMu0283 (srlB) and SMu1207 (srlD).","PTS system, sorbitol (glucitol) phosphotransferase enzyme IIC2","Membrane, Extracellular","This sequence corresponds to the previously sequenced gi|4928285 and gi|11356485 in GenBank, a predicted phosphotransferase enzyme II. Further, residues 1-179 are 53% similar to the EIIC2-GUT from C.beijerinckii (gi|3914488).SMu0281 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004699
Family

Phosphotransferase system, enzyme II sorbitol-specific factor
PF03608	$\"[1-175]T$	EII-GUT
TIGR00821	$\"[1-180]T$	EII-GUT
PS51107	$\"[1-180]T$	PTS_EIIC_TYPE_5

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-179 are 91% similar to a (COMPONENT PHOSPHOTRANSFERASE SYSTEM IIC2) protein domain (PD022527) which is seen in Q9X674_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:05:06 2002","Tue Jan 15 15:42:24 2002","Thu Oct 24 14:05:06 2002","Tue Jan 15 15:42:24 2002","","Tue Jan 15 15:42:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0281 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 15 15:45:41 2002","","No significant hits to the NCBI PDB database.","SMU.311","","Residues 1 to 175 (E-value = 3.2e-147) place SMu0281 in the EII-GUT family which is described as PTS system enzyme II sorbitol-specific factor (PF03608)","Tue Jan 15 15:42:24 2002","24378813","","Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 20107103","Tangney,M., Brehm,J.K., Minton,N.P. and Mitchell,W.J.A gene system for glucitol transport and metabolism in Clostridium beijerinckii NCIMB 8052Appl. Environ. Microbiol. 64 (5), 1612-1619 (1998)PubMed: 9572925","Tue Jan 15 15:45:41 2002","Tue Apr 9 14:43:25 2002","1","","","SMU.311","" "SMu0282","299070","300080","1011","ATGGCTTACAGAAACATTAAAATTGTAAAAGGAAATGGTGGGTTTGGTGGCCCTTTGATTATTGCACCAACTGATGAAAAGCATAAATTTATCTATATCACAGGTGGTGGTGAAAAACCTGAAATTGTTGATAAAATTGTTGAATTAACAGGAATGGAAGCTGTTAATGGTTTTAAAACCTCTATTCCGGATGAAGAAATCGCTCTGGCTATTGTTGACTGTGGTGGCACCCTACGTTGTGGTATTTATCCTAAAAAAGGGATTCCTACGATTAATATTGTTGCAACTGGTAAGAGCGGACCTTTAGCCCAATACATTACTGAAGATATTTATGTTTCGGCTGTTGGTATGGAGCAGATTACCTCAATTGAGGAATCAGCAGGCAGTATTGAAACGAAAGAAGCGAAAGCTGAGACTGCTCAATCTCAAACAGGCACCGGCACCTATGATACCAGTAAAAAAATCACTGAGCAACGTGCACAACAGAGTGTTATTGCTCGTATTGGTATGGGGGCTGGTAAAGTGGTTGCTGTTTTTAATCAAGCAGCGCGTGATGCTATTCAAACATTATTAAATACTATTCTTCCTTTTATGGCTTTTGTATCACTTCTGATTGGTTTTATTCAAGGCTCAGGTGTGGGTAAATGGTTAGCTAAACTCATGGTGCCGCTGGCTGGTAATATTTGGGGACTTATCCTGATCGGATTCATTTGTTCACTACCATTCTTATCACCTCTTCTTGGACCTGGTGCTGTTATTTCACAAATTATTGGCACCTTGATTGGGGTTGAAATTGGTAAGGGAACTATCCCGCCGCAAATGGCTCTCCCAGCTCTTTTTGCTATTAATACGCAAAATGGTTGTGATTTTATCCCTGTGGCGCTTGGCTTGTCTGAGTCAACTGCTGAAACAGTAGAAGTCGGTGTTCCATCTGTTCTTTACTCGCGTTTCCTAAATGGTGTACCACGTGTTATTGTAGCATGGATTGCAAGTATTGGACTTTATCAATAA","5.50","-1.94","35298","MAYRNIKIVKGNGGFGGPLIIAPTDEKHKFIYITGGGEKPEIVDKIVELTGMEAVNGFKTSIPDEEIALAIVDCGGTLRCGIYPKKGIPTINIVATGKSGPLAQYITEDIYVSAVGMEQITSIEESAGSIETKEAKAETAQSQTGTGTYDTSKKITEQRAQQSVIARIGMGAGKVVAVFNQAARDAIQTLLNTILPFMAFVSLLIGFIQGSGVGKWLAKLMVPLAGNIWGLILIGFICSLPFLSPLLGPGAVISQIIGTLIGVEIGKGTIPPQMALPALFAINTQNGCDFIPVALGLSESTAETVEVGVPSVLYSRFLNGVPRVIVAWIASIGLYQ","300077","For other 'srl' genes see SMu0278 (srlD); SMu0280 (srlM); SMu0281 (srlA); SMu0283 (srlB) and SMu1207 (srlD).","PTS system, sorbitol phosphotransferase enzyme IIBC","Membrane, Cytoplasm","This sequence corresponds to the previously sequenced gi|4928286 and gi|11356486 in GenBank, a predicted phosphotransferase enzyme II. Additionally, residues 3-336 are 62% similar to a IIBC COMPONENT from C.beijerinckii (gi|3914489).SMu0282 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004702
Family

Phosphotransferease, sorbitol phosphotransferase enzyme II
TIGR00825	$\"[4-336]T$	EIIBC-GUT

InterPro
IPR011618
Domain

Sorbitol phosphotransferase enzyme II, N-terminal
PF03612	$\"[4-188]T$	EIIBC-GUT_N
PS51102	$\"[2-195]T$	PTS_EIIB_TYPE_5

InterPro
IPR011638
Domain

Sorbitol phosphotransferase enzyme II, C-terminal
PF07663	$\"[243-335]T$	EIIBC-GUT_C

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-336 are 96% similar to a (COMPONENT PHOSPHOTRANSFERASE SYSTEM IIBC) protein domain (PD024543) which is seen in Q9X675_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:05:25 2002","Tue Jan 15 15:50:45 2002","Thu Oct 24 14:05:25 2002","Tue Jan 15 15:50:45 2002","","Tue Jan 15 15:50:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0282 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 15 15:53:58 2002","","No significant hits to the NCBI PDB database.","SMU.312","","Residues 4 to 335 (E-value = 2.4e-263) place SMu0282 in the EIIBC-GUT family which is described as Sorbitol phosphotransferase enzyme II (PF03612)","Tue Jan 15 15:50:45 2002","24378814","","Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 20107103","Tangney,M., Brehm,J.K., Minton,N.P. and Mitchell,W.J.A gene system for glucitol transport and metabolism in Clostridium beijerinckii NCIMB 8052Appl. Environ. Microbiol. 64 (5), 1612-1619 (1998)PubMed: 9572925","Tue Jan 15 15:53:58 2002","Tue Apr 9 14:44:31 2002","1","","","SMU.312","" "SMu0283","300122","300487","366","ATGACTAAAATTTTTGAAGCAAAAGTGCTGGCTGTTGGACCAGAAGCTCTCAGCATGATTAAAGATGCTAATATGCTTATTCTCTTTGGAGAAGAGGCTCCTCAAGATCTGGCAGATTATTGTTATAAAATTGATAATAAAAATCTAAGTGGGCATATTAAAAAGGGCGGGCATCTTGTTATTAATGGTAATGACTGTCAAATTACAGCTGTTGGCAGTGTTGTTGAAAAGAATTTAACAGGACTTGGCCATATCACTATCTCATTGGATGGTTCAAAGGAAAGTTCATTACCGGGAACACTTCATATACAAGCAGAATTCCCTGTTCAGCTTGAAGCAGGTTCCCTTATTCAAATTTTTGATTAG","4.90","-5.14","12933","MTKIFEAKVLAVGPEALSMIKDANMLILFGEEAPQDLADYCYKIDNKNLSGHIKKGGHLVINGNDCQITAVGSVVEKNLTGLGHITISLDGSKESSLPGTLHIQAEFPVQLEAGSLIQIFD","300484","For other 'srl' genes see SMu0278 (srlD); SMu0280 (srlM); SMu0281 (srlA); SMu0282 (srlE) and SMu1207 (srlD).","PTS system, sorbitol-specific enzyme IIA","Cytoplasm","This sequence corresponds to the previously sequenced gi|4928287 and gi|11260473 in GenBank, a predicted phosphotransferase enzyme IIA. Weak similarities are observed to gi|2582657, a predicted GutB from C. beijerinckii. Residues 4-119 are 43% similar to this sequence.SMu0283 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004716
Family

Phosphotransferase system, glucitol/sorbitol-specific IIA component
PD015842	$\"[8-118]T$	PTSIIA_gutA
PIRSF000698	$\"[1-121]T$	PTS_glc_srb_IIA
PF03829	$\"[1-118]T$	PTSIIA_gutA
PS51097	$\"[3-117]T$	PTS_EIIA_TYPE_5

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-119 are identical to a (ENZYME IIA PHOSPHOTRANSFERASE COMPONENT) protein domain (PD015842) which is seen in Q9X676_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:05:46 2002","Tue Jan 15 16:00:29 2002","Thu Oct 24 14:05:46 2002","Tue Jan 15 16:00:29 2002","","Tue Jan 15 16:00:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0283 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 15 16:02:39 2002","","No significant hits to the NCBI PDB database.","SMU.313","","Residues 1 to 118 (E-value = 2.9e-74) place SMu0283 in the PTSIIA_gutA family which is described as PTS system glucitol/sorbitol-specific IIA component (PF03829)","Tue Jan 15 16:00:29 2002","24378815","","Boyd,D.A., Thevenot,T., Gumbmann,M., Honeyman,A.L. andHamilton,I.R.Identification of the operon for the sorbitol (Glucitol)Phosphoenolpyruvate:Sugar phosphotransferase system inStreptococcus mutansInfect. Immun. 68 (2), 925-930 (2000)PubMed: 20107103","Tangney,M., Brehm,J.K., Minton,N.P. and Mitchell,W.J.A gene system for glucitol transport and metabolism in Clostridium beijerinckii NCIMB 8052Appl. Environ. Microbiol. 64 (5), 1612-1619 (1998)PubMed: 9572925","Tue Jan 15 16:06:09 2002","Tue Apr 9 14:45:15 2002","1","","","SMU.313","" "SMu0284","300738","300899","162","ATGGAAAATCTCAATATAGCTACCACCATCGCACTTATCGCAGGAAACATTGCACAAGCAAGAGCCGCGGCAAAAGTTCTTGGAGCCAGTTATAAAAAGGTTGAGCAGATAAATCGTACCTTAGAAGTTGGCGTATCAACTGTCGCTGTTAGTCTCAATTAA","10.40","1.98","5480","MENLNIATTIALIAGNIAQARAAAKVLGASYKKVEQINRTLEVGVSTVAVSLN","300896","","hypothetical protein","Cytoplasm, Extracellular","No significant matches in gapped BLAST.SMu0284 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide

InterPro
IPR001451
Repeat

Bacterial transferase hexapeptide repeat
PF00132	$\"[87-104]T$ $\"[117-134]T$ $\"[135-152]T$ $\"[161-178]T$ $\"[179-196]T$	Hexapep
PS00101	$\"[126-154]?$ $\"[170-198]?$	HEXAPEP_TRANSFERASES

InterPro
IPR011004
Domain

Trimeric LpxA-like
SSF51161	$\"[47-230]T$	Trimer_LpxA_like

InterPro
IPR013710
Domain

Tetrahydrodipicolinate succinyltransferase N-terminal
PF08503	$\"[6-83]T$	DapD_N

noIPR
unintegrated

unintegrated
G3DSA:2.160.10.10	$\"[72-215]T$	G3DSA:2.160.10.10
PTHR23416	$\"[80-216]T$	PTHR23416
PTHR23416:SF7	$\"[80-216]T$	PTHR23416:SF7

","BeTs to 4 clades of COG2171COG name: Tetrahydrodipicolinate N-succinyltransferaseFunctional Class: EThe phylogenetic pattern of COG2171 is ------v-eb-h--------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001451 (Bacterial transferase hexapeptide repeat) with a combined E-value of 5.4e-17. IPB001451 164-199 IPB001451 120-155 IPB001451 158-193 IPB001451 126-161 IPB001451 102-137 IPB001451 96-131 IPB001451 114-149 IPB001451 84-119 IPB001451 108-143 IPB001451 90-125 IPB001451 170-205 IPB001451 146-181 IPB001451 132-167","Residues 164-213 are 54% similar to a (TRANSFERASE ACETYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD013088) which is seen in Q9CIS5_LACLA.Residues 6-88 are 47% similar to a (PROTEOME COMPLETE TETRAHYDRODIPICOLINATE) protein domain (PD404517) which is seen in Q9K9H8_BACHD.Residues 89-156 are 76% similar to a (TRANSFERASE PROTEOME COMPLETE) protein domain (PD404267) which is seen in Q9CIS5_LACLA.Residues 1-88 are 51% similar to a (PROTEOME TRANSFERASE ACETYLTRANSFERASE) protein domain (PD395480) which is seen in Q9CIS5_LACLA.Residues 89-153 are 67% similar to a (COMPLETE PROTEOME TRANSFERASE ACYLTRANSFERASE LIPID) protein domain (PD000343) which is seen in Q9K9H8_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 15 16:25:26 2002","Tue Jan 15 16:21:10 2002","Thu Aug 31 09:10:08 2006","Tue Oct 22 16:16:25 2002","Tue Jan 15 16:21:10 2002","Tue Jan 15 16:21:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0285 is paralogously related (blast p-value < 1e-3) to SMu0140, a predicted serine acetyltransferase, and to SMu1488, a predicted UDP-N-acetylglucosamine pyrophosphorylase.","Tue Jan 15 16:39:27 2002","Thu Aug 31 09:10:08 2006","pdb3TDT Complex Of Tetrahydrodipicolinate N-Succinyltransfe... 146 2e-036","SMU.317","","No significant hits to the Pfam 11.0 database","Tue Jan 15 16:21:10 2002","24378817","","","Shaw-Reid CA, McCormick MM, Sinskey AJ, Stephanopoulos G.Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacteriumglutamicum.Appl Microbiol Biotechnol. 1999 Mar;51(3):325-33.PMID: 10222581 Beaman TW, Blanchard JS, Roderick SL.The conformational change and active site structure of tetrahydrodipicolinate N-succinyltransferase.Biochemistry. 1998 Jul 21;37(29):10363-9.PMID: 9671504 Beaman TW, Binder DA, Blanchard JS, Roderick SL.Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase.Biochemistry. 1997 Jan 21;36(3):489-94.PMID: 9012664 Binder DA, Blanchard JS, Roderick SL.Crystallization and preliminary crystallographic analysis of tetrahydrodipicolinate-N-succinyltransferase.Proteins. 1996 Sep;26(1):115-7.PMID: 8880935","","Tue Jan 15 16:37:20 2002","1","","","SMU.317","1015" "SMu0286","302577","303707","1131","ATGACTTTAGATTTAATCAAAATTCGTCGTGATTTGCATCAAATTCCAGAGATTGGTCTGGAAGAATTTAAAACGCAAGCTTATCTCTTAGAACGTATTGCTGAAATCACCAATGGTAAAGACTTTGTTGAGCAGAGGACTTGGCGTACAGGGATTTTAGTCTTTTTAAAAGGTTCTCGTCCTCAAAAAACAATCGGTTGGCGTACCGATATTGATGCGCTTCCTGTCGTTGAAGAAACAGGGCTTGCTTTTGCCAGTCAGCATGAAGGGCGTATGCATGCTTGCGGCCATGATATGCATATGACCATTGCTCTTGGCTTACTTGATACAATGGTGCAAGTACAGCCTAAAAATAACTTACTCTTTCTTTTTCAGCCAGCAGAAGAAAATGAAGCAGGTGGTATGCTCATGTATGAAGATGGCGCCTTTGGTAATTGGCAGCCTGATGAATTCTATGGTTTGCATGTCCGCCCAGATTTTAAAGTTGGTGATATTGCAACTAATACATCTACCTTATTTGCTGGGACTTGTGAAGTTTTCATCACTTTCAAAGGTAAGGGCGGTCATGCTGCCTTTCCTCATAATGCTAATGATGCCCTTGTAGCTGCTTCTTACTTTATTACACAAGTTCAAACCATTGTCAGTCGTAATGTTGATCCCATTGAGGGTGGAGTTGTGACCTTTGGTTCTATGCATGCTGGGACAACCAATAATGTTATTGCTGAAACAGCTACTTTACATGGAACCATCCGAACCCTGACTCAGGACATGAGTCTTTTGATTCAAAAGCGGGTGCAGGAAATGGCTCGAGGAATTGCAACTTCTTTTGATTTAGAAGTAGATGTTACGCTCAAACAAGGTGGCTATTTGCCAGTTGAAAATAATTCTCAATTGGCTAAACAATTGATGACTTATTTTGAAAATGCGTCTGCTGTCAATTTGATAGACTGTTTACCAGCTATGACTGGTGAAGATTTTGGCTATCTGCTCAATAAAATCCCCGGTGTTATGTTCTGGCTGGGAATTGACACACCTTATGCACTTCATCATCCTAAGATGAGTCCCAAGGAAGAAGTTTTGTCATTTGCAGTTGATAATATTAGTGGCTTCTTGAAGACCAGAACGAATTAA","5.30","-11.23","41689","MTLDLIKIRRDLHQIPEIGLEEFKTQAYLLERIAEITNGKDFVEQRTWRTGILVFLKGSRPQKTIGWRTDIDALPVVEETGLAFASQHEGRMHACGHDMHMTIALGLLDTMVQVQPKNNLLFLFQPAEENEAGGMLMYEDGAFGNWQPDEFYGLHVRPDFKVGDIATNTSTLFAGTCEVFITFKGKGGHAAFPHNANDALVAASYFITQVQTIVSRNVDPIEGGVVTFGSMHAGTTNNVIAETATLHGTIRTLTQDMSLLIQKRVQEMARGIATSFDLEVDVTLKQGGYLPVENNSQLAKQLMTYFENASAVNLIDCLPAMTGEDFGYLLNKIPGVMFWLGIDTPYALHHPKMSPKEEVLSFAVDNISGFLKTRTN","303704","","peptidase/aminoacylase/hippurate hydrolase","Cytoplasm","Matches in gapped BLAST to hippurate hydrolases and peptidases. Residues 3-374 are 75% similar to gi15903947 from S.pneumoniae. Residues 3-376 are 69% similar to gi15672264 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1523 (1e-54).","

InterPro
IPR002933
Family

Peptidase M20
PF01546	$\"[66-373]T$	Peptidase_M20

InterPro
IPR010168
Family

Peptidase M20D, amidohydrolase
TIGR01891	$\"[5-363]T$	amidohydrolases

InterPro
IPR011650
Domain

Peptidase M20, dimerisation
PF07687	$\"[171-277]T$	M20_dimer

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.10	$\"[4-374]T$	G3DSA:3.40.630.10
SSF53187	$\"[4-376]T$	SSF53187
SSF55031	$\"[175-289]T$	SSF55031

","BeTs to 6 clades of COG1473COG name: Metal-dependent amidohydrolases/aminoacylasesFunctional Class: RThe phylogenetic pattern of COG1473 is ---K--vCEBRh---------Number of proteins in this genome belonging to this COG is 2","***** IPB002933 (Peptidase family M20/M25/M40) with a combined E-value of 4.5e-08. IPB002933B 175-191 IPB002933C 238-251","Residues 313-360 are 75% similar to a (HYDROLASE PROTEOME COMPLETE) protein domain (PD004654) which is seen in Q9CIS4_LACLA.Residues 136-251 are 79% similar to a (HYDROLASE ACID PROTEOME COMPLETE) protein domain (PD001757) which is seen in Q9CIS4_LACLA.Residues 268-369 are 29% similar to a (HYDROLASE COMPLETE PROTEOME) protein domain (PD038198) which is seen in O07598_BACSU.Residues 140-351 are 22% similar to a (COMPLETE FIXR GENES CDSS) protein domain (PD148485) which is seen in Q44415_AGRTU.Residues 252-307 are 57% similar to a (PROTEOME AMINO COMPLETE AMIDOHYDROLASE) protein domain (PD385465) which is seen in Q9CIS4_LACLA.Residues 5-133 are 43% similar to a (HYDROLASE PROTEOME COMPLETE ACID) protein domain (PD376484) which is seen in YTNL_BACSU.Residues 181-269 are 35% similar to a (PROTEOME COMPLETE HYDROLASE DEACETYLASE) protein domain (PD293379) which is seen in Y4TI_RHISN.Residues 4-133 are 69% similar to a (HYDROLASE ACID COMPLETE PROTEOME) protein domain (PD002630) which is seen in Q9CIS4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 09:14:53 2002","Tue Feb 13 12:52:51 2007","Tue Feb 13 12:52:51 2007","Tue Oct 29 08:09:49 2002","Wed Jan 16 09:11:47 2002","Wed Jan 16 09:11:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0286 is paralogously related (blast p-value < 1e-3) to SMu0118, a predicted amino acid amidohydrolase.","Wed Jan 16 11:30:03 2002","","No significant hits to the NCBI PDB database.","SMU.318","","Residues 2 to 376 (E-value = 3.1e-88) place SMu0286 in the Peptidase_M20 family which is described as Peptidase family M20/M25/M40 (PF01546)","Wed Jan 16 09:11:47 2002","24378818","","","","","","1","","","SMU.318","" "SMu0287","304041","304577","537","ATGATGAAAAAGGACTATCGTACTCAAGTCATTGAAGATTTGAAAAAACAAGATAAAGCCAAAAAAGTGCTCAGAGATGAGCAACTTTTGGAAGAACTTATTCAATTAGAGGCTTATCAAAAAGCACATGTTATTGCAACTTATTTAGCTTTTCCTTTTGAATTTGACACATCTTTGCTGATTGAGCAAGCTCAAAGAGATAATAAAAGCATAGTTGTTCCTAAAACCTATCCTCAAGGGAAAATGATTTTTGTTGTTTATGATGAAGCAGATTTACAAATTACTAAATTTGGCCTCAAGGAACCAAGAAGTGAGGAGGCTCTTGAAAAATCAGCTATTGATCTCATCCATGTTCCGGGGCTTGCTTTTAACAATGAAGGCTACCGTATAGGTTTTGGTGCGGGATATTATGATCAATACTTGGCAGATTTTCAGGGTGATACAGTCAGCACAATTTATTCTTTTCAAAAGTTCACTTTTGAGCCTAGTTTTTTTGACATTCCAGTAAAGGAGGTGTTGGTCAGTGGAGACCTTTAA","4.70","-7.51","20498","MMKKDYRTQVIEDLKKQDKAKKVLRDEQLLEELIQLEAYQKAHVIATYLAFPFEFDTSLLIEQAQRDNKSIVVPKTYPQGKMIFVVYDEADLQITKFGLKEPRSEEALEKSAIDLIHVPGLAFNNEGYRIGFGAGYYDQYLADFQGDTVSTIYSFQKFTFEPSFFDIPVKEVLVSGDL","304574","","probable 5-formyltetrahydrofolate cyclo-ligase","Cytoplasm","This sequence corresponds to the previously published gi3192049 in GenBank, an unknown. Also, esidues 2-174 are 50% similar to a predicted 5-formyltetrahydrofolate cyclo-ligase family protein from S.pneumoniae (gi15901910).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0403 (5e-48).","

InterPro
IPR002698
Family

5-formyltetrahydrofolate cyclo-ligase
PTHR23407:SF1	$\"[1-156]T$	FTHF_cligase
PF01812	$\"[3-175]T$	5-FTHF_cyc-lig
TIGR02727	$\"[3-175]T$	MTHFS_bact

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10420	$\"[2-178]T$	G3DSA:3.40.50.10420
PTHR23407	$\"[1-156]T$	PTHR23407
SSF100950	$\"[1-173]T$	SSF100950

","BeTs to 12 clades of COG0212COG name: 5-formyltetrahydrofolate cyclo-ligaseFunctional Class: HThe phylogenetic pattern of COG0212 is --t-yq-cebrhujgp-linxNumber of proteins in this genome belonging to this COG is 1","***** IPB002698 (5-formyltetrahydrofolate cyclo-ligase) with a combined E-value of 2.5e-17. IPB002698 114-142","Residues 1-169 are 92% similar to a (PROTEOME COMPLETE SYNTHETASE 5-FORMYLTETRAHYDROFOLATE) protein domain (PD004590) which is seen in O66124_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 09:18:25 2002","Thu Jul 6 16:30:25 2006","Thu Jul 6 16:30:25 2006","Tue Oct 8 08:42:13 2002","Wed Jan 16 09:16:15 2002","Wed Jan 16 09:16:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0287 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 09:18:25 2002","","No significant hits to the NCBI PDB database.","SMU.320","","Residues 3 to 175 (E-value = 7e-64) place SMu0287 in the 5-FTHF_cyc-lig family which is described as 5-formyltetrahydrofolate cyclo-ligase family (PF01812)","Wed Jan 16 09:16:15 2002","24378819","","","","Thu Jul 6 16:30:25 2006","","1","","","SMU.320","770" "SMu0288","304564","305235","672","GTGGAGACCTTTAAAAAATATCCTGCAACTTCTTTTTTAGTCCTGCTAACGACTCTCGTTTTTTTGACGATGCAAGTTGTTTATTTAGGACAAGCAAATACCACCTTAGCTGTTTTTAATTTTGGTGGGATGTATGGTGACTTGGTTGTTCACAATCCCAATCAGCTTTGGCGTTTGATCACTCCGATTTTTGTTCATATCGGTTGGGAACATTTCCTATTTAATAGTTTAGCACTTTATTTTGTCGGTCAATTGGCAGAAAATATTTGGGGCTCGTGGCGATTTCTGCTCCTGTACCTTTTGTCAGGAATTATGGGAAATATTTTTACGCTTTATTTGACTCCAAATGTAGTTGCAGCAGGTGCTTCAACTTCTTTGTTTGGGCTTTTTGCGGCGATTGTTGTCCTAGGTTATTTTGGACACAACCCATATTTAAAACAGTTGGGACGCAGCTATCAAGCTTTAATTGTGGTTAATCTTATTTTTAATCTTTTTATGCCTGATATTAGTATTGCAGGACATCTAGGAGGGATTATTGGTGGGATTTGCTCTGCTTTTATATTGCCTAGTTTTGCTGAAGGAAAACTTTTCTCTCTTAGGCAACGCTTGCCCATTTTAATTTTGTATTTATGCCTTGCTTCTGGAATCCTTTATCTGGCCTTTAATAAATAA","9.80","5.09","24756","METFKKYPATSFLVLLTTLVFLTMQVVYLGQANTTLAVFNFGGMYGDLVVHNPNQLWRLITPIFVHIGWEHFLFNSLALYFVGQLAENIWGSWRFLLLYLLSGIMGNIFTLYLTPNVVAAGASTSLFGLFAAIVVLGYFGHNPYLKQLGRSYQALIVVNLIFNLFMPDISIAGHLGGIIGGICSAFILPSFAEGKLFSLRQRLPILILYLCLASGILYLAFNK","305232","","conserved hypothetical protein, Rhomboid family","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypothetical proteins. Residues 4-220 are 54% similar to gi7739965 from S.uberis. Residues 5-2118 are 42% similar to gi15903945 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0404 (2e-59).","

InterPro
IPR002610
Family

Peptidase S54, rhomboid
PTHR22936	$\"[12-221]T$	RHOMBOID-RELATED
PF01694	$\"[50-193]T$	Rhomboid

noIPR
unintegrated

unintegrated
signalp	$\"[1-37]?$	signal-peptide
tmhmm	$\"[12-32]?$ $\"[63-83]?$ $\"[95-113]?$ $\"[119-139]?$ $\"[148-166]?$ $\"[172-192]?$ $\"[202-222]?$	transmembrane_regions

","BeTs to 10 clades of COG0705COG name: Uncharacterized membrane protein (homolog of Drosophila rhomboid)Functional Class: RThe phylogenetic pattern of COG0705 is am-kYqVceBRh-----l---Number of proteins in this genome belonging to this COG is 1","***** IPB002610 (Rhomboid family) with a combined E-value of 1.3e-11. IPB002610A 66-75 IPB002610B 121-131 IPB002610C 173-183","Residues 32-100 are 43% similar to a (COMPLETE PROTEOME MEMBRANE TRANSMEMBRANE) protein domain (PD003871) which is seen in Q9CJ36_LACLA.Residues 102-165 are 59% similar to a (COMPLETE PROTEOME MEMBRANE TRANSMEMBRANE) protein domain (PD097600) which is seen in Q9CJ36_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 26 11:09:01 2006","Wed Jul 26 11:09:01 2006","Wed Jul 26 11:09:01 2006","Wed Jul 26 11:09:01 2006","Wed Jan 16 11:29:02 2002","Wed Jan 16 11:29:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0288 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jul 26 11:09:01 2006","","No significant hits to the NCBI PDB database.","SMU.321","","Residues 51 to 193 (E-value = 2.9e-47) place SMu0288 in the Rhomboid family which is described as Rhomboid family (PF01694)","Wed Jan 16 11:29:02 2002","24378820","","","Ward,P.N., Field,T.R., Ditcham,W.G., Maguin,E. and Leigh,J.A.Identification and Disruption of Two Discrete Loci EncodingHyaluronic Acid Capsule Biosynthesis Genes hasA, hasB, and hasC inStreptococcus uberisInfect. Immun. 69 (1), 392-399 (2001)PUBMED 11119529","","Wed Jan 16 11:29:02 2002","1","","","SMU.321","644" "SMu0289","306177","305257","921","ATGCCAAGTAAAAAAGTCAGAAAAGCTGTCATCCCTGCGGCAGGTTTAGGAACACGTTTCCTTCCTGCTACCAAGGCTCTTGCCAAAGAAATGCTACCAATTGTTGATAAACCAACCATTCAGTTTATCGTTGAAGAAGCTTTAAAATCAGGCATTGAAGACATCCTAGTGGTTACAGGTAAATCAAAACGTTCTATTGAAGATCATTTTGATTCAAATTTTGAACTTGAGTACAATCTTGAACAAAAAGGAAAAACAGATTTACTTAAACTCGTTAATGATACTACTGCAATCAATCTCCATTTTATCCGTCAAAGCCATCCGCGCGGGTTAGGTGATGCTGTTCTTCAGGCTAAAGCCTTTGTAGGTAATGAACCTTTCGTTGTTATGCTCGGTGATGATTTGATGGATATTACAGATGACAAGGCTATCCCTTTGACACGTCAACTCATGAACGATTATGAAGAAACGCATGCCTCAACGATTGCAGTCATGGAGGTTCCCCATGAAGATGTTTCTGCCTATGGTGTAATTGCTCCTCAAGGAGAAGGAGTTAGTGGCCTTTACAGTGTCGATACTTTTGTTGAAAAGCCTGCTCCTAAAGAAGCGCCTAGCAATCTAGCTATCATTGGTCGTTACTTATTAACGCCGGAAATTTTTACAATTCTTGAAACACAAGAACCCGGTGCTGGCAACGAAGTTCAATTAACAGATGCCATTGATACTCTTAATAAAACACAACGTGTTTTTGCACGTGAATTTAAGGGAAAACGTTATGATGTTGGTGATAAATTTGGTTTCATGAAGACTTCAATTGATTATGCACTTAAACATCCACAAGTTAAAGAAGATTTAAAAGCTTATATTATTGAACTTGGTAAAAAATTAGACCAAAAATCGACTCAAAAGAACTCGGATTAA","5.40","-6.53","33891","MPSKKVRKAVIPAAGLGTRFLPATKALAKEMLPIVDKPTIQFIVEEALKSGIEDILVVTGKSKRSIEDHFDSNFELEYNLEQKGKTDLLKLVNDTTAINLHFIRQSHPRGLGDAVLQAKAFVGNEPFVVMLGDDLMDITDDKAIPLTRQLMNDYEETHASTIAVMEVPHEDVSAYGVIAPQGEGVSGLYSVDTFVEKPAPKEAPSNLAIIGRYLLTPEIFTILETQEPGAGNEVQLTDAIDTLNKTQRVFAREFKGKRYDVGDKFGFMKTSIDYALKHPQVKEDLKAYIIELGKKLDQKSTQKNSD","305260","For other 'gal' genes see SMu0807 (galR); SMu0808 (galK); SMu0809 (galT); SMu0810 (galE) and SMu1874 (galE). ","glucose-1-phosphate uridylyltransferase","Cytoplasm","This sequence corresponds to the previously sequenced gi3192048 in GenBank, a predicted glucose-1-phosphate uridylyltransferase. See also gi1813345, gi2500162. Residues 1-303 are 88% similar to the enzyme from S.thermophilus (gi15722252).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0406 (1e-151).","

InterPro
IPR005771
Family

UTP--glucose-1-phosphate uridylyltransferase, bacterial and archaeal type
TIGR01099	$\"[6-270]T$	galU

InterPro
IPR005835
Domain

Nucleotidyl transferase
PF00483	$\"[8-276]T$	NTP_transferase

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[5-282]T$	G3DSA:3.90.550.10
PTHR22572	$\"[15-79]T$ $\"[100-300]T$	PTHR22572
PTHR22572:SF14	$\"[15-79]T$ $\"[100-300]T$	PTHR22572:SF14
SSF53448	$\"[7-282]T$	SSF53448

","BeTs to 9 clades of COG1210COG name: UDP-glucose pyrophosphorylaseFunctional Class: MThe phylogenetic pattern of COG1210 is -mt--q--EBrhujgpo----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 9-133 are 88% similar to a (TRANSFERASE COMPLETE PROTEOME BIOSYNTHESIS) protein domain (PD000318) which is seen in Q9CFX5_LACLA.Residues 67-133 are identical to a (URIDYLYLTRANSFERASE PYROPHOSPHORYLASE) protein domain (PD036351) which is seen in O66123_STRMU.Residues 16-66 are 90% similar to a (URIDYLYLTRANSFERASE PYROPHOSPHORYLASE) protein domain (PD408709) which is seen in CAPC_STRPN.Residues 9-66 are 51% similar to a (PROTEOME COMPLETE URIDYLYLTRANSFERASE) protein domain (PD413010) which is seen in Q9Z5G1_MYCLE.Residues 175-262 are 38% similar to a (TRANSFERASE GLUCOSE-1-PHOSPHATE) protein domain (PD000406) which is seen in Q9RZC3_DEIRA.Residues 175-262 are identical to a (TRANSFERASE PYROPHOSPHORYLASE ADP-GLUCOSE) protein domain (PD001252) which is seen in O66123_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 09:51:47 2006","Wed Jan 16 11:31:28 2002","Thu Sep 7 09:51:47 2006","Tue Apr 2 10:43:11 2002","","Wed Jan 16 11:31:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0289 is paralogously related (blast p-value < 1e-3) to SMu1330, a predicted glucose-1-phosphate thymidyltransferase and to SMu1330 a predicted glucose-1-phosphate.","Wed Jan 16 11:45:01 2002","Thu Sep 7 09:51:47 2006","pdb1FXOA Chain A, The Structural Basis Of The Catalytic Mecha... 78 1e-015pdb1G23A Chain A, The Structural Basis Of The Catalytic Mecha... 78 2e-015","SMU.322c","","Residues 8 to 277 (E-value = 5.2e-23) place SMu0289 in the NTP_transferase family which is described as Nucleotidyl transferase (PF00483)","Wed Jan 16 11:31:28 2002","24378821","","Yamashita,Y., Tsukioka,Y., Nakano,Y., Tomihisa,K., Oho,T. andKoga,T.Biological functions of UDP-glucose synthesis in StreptococcusmutansMicrobiology 144 (Pt 5), 1235-1245 (1998)PubMed: 9611798","Boels IC, Ramos A, Kleerebezem M, de Vos WM.Functional analysis of the Lactococcus lactis galU and galE genes and their impact on sugar nucleotide and exopolysaccharide biosynthesis.Appl Environ Microbiol. 2001 Jul;67(7):3033-40.PMID: 11425718Mollerach M, Garcia E.The galU gene of Streptococcus pneumoniae that codes for a UDP-glucose pyrophosphorylase is highly polymorphic and suitable for molecular typing and phylogeneticstudies.Gene. 2000 Dec 30;260(1-2):77-86.PMID: 11137293","Thu Sep 7 09:51:47 2006","Wed Jan 16 11:50:26 2002","1","","","SMU.322c","275" "SMu0290","307198","306179","1020","ATGATCAGACAAAAAATTGCCGTACTAGGTCCTGGTTCTTGGGGAACCGCCTTATCCCAAGTTCTTAACGACAATGGTCATGAAGTCCGTATCTGGGGAAATATTCCTGAACAGCTTGATGAAATTAATGAACATCATACTAACAAGCGTTATTTTAAGGATGTGGTCCTAGATGAAAAAATCAAAGCTTATCACGATTTAGAGGATGCTCTTAAGGATATTGATGCTGTCCTTTTTGTTGTTCCAACAAAAGTAACACGCTTGGTGGCCAAGCAAGTTTCACAAATTCTTGATCACAAAGCCGTTGTCATGCACGCTTCTAAAGGCTTGGAGCCGGGCACTCACGAACGCTTATCTGTCATTCTTGAAGAAGAAATTCCAAATCATCTTCGAAGCGACATAGTTGTTGTTTCTGGACCCAGCCATGCTGAGGAAACCATCGTGCGCGATATTACCCTGATTACAGCGGCATCTAAAGATTTAGAAGCCGCCAAATACGTTCAAAAGCTCTTTAGCAACAACTATTTTCGTCTTTACACCAATCCCGATGTTATTGGTGTGGAAACTGCTGGTGCTCTGAAAAATATCATTGCTGTTGGGGCAGGAGCACTCCATGGGATGGGGTATGGTGATAATGCTAAAGCAGCTGTTATCACACGCGGTCTAGCCGAAATTACACGTTTAGGCGTCAAACTGGGAGCTGATCCGCTCACTTACAGCGGTCTGTCTGGTGTTGGAGATTTGATTGTTACTGGAACTTCTATCTATTCACGTAATTGGCGGGCCGGAGATGCTCTAGGACGCGGAGAAAAATTGGAAGACATTGAAAGAAATATGGGAATGGTTATTGAAGGAATTTCCACAACAAAGGTCGCCTACGAACTTTCTCGAGAACTCAACGTCTATATGCCAATTACCTGTGCTATTTATCAGTCAATTTATGAAGGCAAAAATATTAAAGAAGCTATCACTTCTATGATGTCAAATGAGTTTAGAGCGGAAAATGAATGGAGTAAATAA","6.00","-5.61","37300","MIRQKIAVLGPGSWGTALSQVLNDNGHEVRIWGNIPEQLDEINEHHTNKRYFKDVVLDEKIKAYHDLEDALKDIDAVLFVVPTKVTRLVAKQVSQILDHKAVVMHASKGLEPGTHERLSVILEEEIPNHLRSDIVVVSGPSHAEETIVRDITLITAASKDLEAAKYVQKLFSNNYFRLYTNPDVIGVETAGALKNIIAVGAGALHGMGYGDNAKAAVITRGLAEITRLGVKLGADPLTYSGLSGVGDLIVTGTSIYSRNWRAGDALGRGEKLEDIERNMGMVIEGISTTKVAYELSRELNVYMPITCAIYQSIYEGKNIKEAITSMMSNEFRAENEWSK","306182","","glycerol-3-phosphate dehydrogenase (NAD(P)+)","Cytoplasm","This sequence corresponds to the previously sequenced gi15625452, a predicted gpdA gene in GenBank.Additionally there were matches in gapped BLAST to glycerol-3-phosphate dehydrogenases from other bacteria, e.g. residues 1-337 are 83% similar to the enzyme from S.pyogenes (gi15674414).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0407 (1e-164).","

InterPro
IPR006109
Domain

NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal
PD001278	$\"[208-315]T$	NAD_Gly3P_C
PF07479	$\"[182-326]T$	NAD_Gly3P_dh_C

InterPro
IPR006168
Family

NAD-dependent glycerol-3-phosphate dehydrogenase
PR00077	$\"[8-25]T$ $\"[58-85]T$ $\"[136-156]T$ $\"[176-200]T$ $\"[201-225]T$ $\"[241-258]T$	GPDHDRGNASE
PTHR11728	$\"[5-334]T$	NAD_Gly3P_DH
PS00957	$\"[191-212]T$	NAD_G3PDH

InterPro
IPR008927
Domain

6-phosphogluconate dehydrogenase, C-terminal-like
SSF48179	$\"[182-334]T$	6DGDH_C_like

InterPro
IPR011128
Domain

NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal
PF01210	$\"[4-165]T$	NAD_Gly3P_dh_N

InterPro
IPR013328
Domain

Dehydrogenase, multihelical
G3DSA:1.10.1040.10	$\"[192-334]T$	Opine_DH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[5-190]T$	G3DSA:3.40.50.720
PIRSF000114	$\"[4-330]T$	Glycerol-3-P_dh
SSF51735	$\"[1-183]T$	SSF51735

","BeTs to 14 clades of COG0240COG name: Glycerol 3-phosphate dehydrogenaseFunctional Class: CThe phylogenetic pattern of COG0240 is a-t-YqvcebRhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001652 (NAD-dependent glycerol-3-phosphate dehydrogenase) with a combined E-value of 6.8e-48. IPB001652A 6-23 IPB001652C 39-84 IPB001652E 136-152 IPB001652F 186-225 IPB001652G 238-259 IPB001652H 274-310","Residues 5-334 are 20% similar to a (NAD OXIDOREDUCTASE DEHYDROGENASE T32G6.6) protein domain (PD102917) which is seen in O22216_ARATH.Residues 5-320 are 79% similar to a (NAD DEHYDROGENASE OXIDOREDUCTASE) protein domain (PD001649) which is seen in Q9CFX6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 17:01:34 2002","Thu Sep 7 10:23:45 2006","Thu Sep 7 10:21:52 2006","Thu Sep 7 10:21:52 2006","Fri Jan 11 17:00:42 2002","Fri Jan 11 17:00:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0290 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 17:01:34 2002","","No significant hits to the NCBI PDB database.","SMU.323c","","Residues 5 to 326 (E-value = 1.7e-134) place SMu0290 in the NAD_Gly3P_dh family which is described as NAD-dependent glycerol-3-phosphate dehydrogenase (PF01210)","Fri Jan 11 17:00:42 2002","","","","Maret W, Yetman CA, Jiang L.Enzyme regulation by reversible zinc inhibition: glycerol phosphate dehydrogenase as an example.Chem Biol Interact. 2001 Jan 30;130-132(1-3):891-901.PMID: 11306104","Thu Sep 7 10:21:52 2006","Fri Jan 11 17:12:31 2002","1","","","SMU.323c","276" "SMu0291","307519","307965","447","GTGATGAAAACACGTGGTTTTGAATTAATTACTGACTATACTGATGAAAATCTTTTGCCAAAGCGGGAAACAGCTCATGCAGCTGGTTATGATCTGAAAGTGGCAGAGCGGACGGAAATTTCTGCGGGAGCAATTGTTCTGGTCCCAACAGGTGTCAAAGCTTATATGCAGGTTGGTGAAGTTCTCTATCTTTTTGATCGTTCGTCCAATCCTCGTAAAAAAGGCTTGGTATTGATTAATTCAGTTGGGGTTATTGATGGCGATTATTACAATAACCCTAATAATGAAGGTCATATTTTTGCTCAGATGAAAAATATGACAGACCAAACAGTTGTGCTTGAAGCTGGAGAACGTGTGGTTCAAGGTGTTTTTATGCCTTTTCTGTTAATAGATGGTGATAAAGCGACTGGCACACGTACAGGCGGTTTTGGATCAACTGGAGGATAG","5.30","-2.52","16045","MMKTRGFELITDYTDENLLPKRETAHAAGYDLKVAERTEISAGAIVLVPTGVKAYMQVGEVLYLFDRSSNPRKKGLVLINSVGVIDGDYYNNPNNEGHIFAQMKNMTDQTVVLEAGERVVQGVFMPFLLIDGDKATGTRTGGFGSTGG","307962","","dUTP diphosphatase (dUTPase)","Periplasm, Cytoplasm","This sequence corresponds to the previously sequenced DutA in GenBank (gi15625451). Additionally residues 2-135 are 80% similar to gi15899969 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0109 (3e-56).","

InterPro
IPR008180
Domain

DeoxyUTP pyrophosphatase
PF00692	$\"[15-147]T$	dUTPase

noIPR
unintegrated

unintegrated
G3DSA:2.70.40.10	$\"[9-147]T$	no description
PTHR11241	$\"[10-147]T$	DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE

","BeTs to 9 clades of COG0756COG name: dUTPaseFunctional Class: FThe phylogenetic pattern of COG0756 is ----yq--eBrhuj---linxNumber of proteins in this genome belonging to this COG is 1","***** IPB001428 (dUTPase) with a combined E-value of 2.1e-18. IPB001428A 22-32 IPB001428B 77-95 IPB001428C 115-126 IPB001428D 138-147","Residues 83-134 are 75% similar to a (HYDROLASE DUTPASE DEOXYURIDINE NUCLEOTIDOHYDROLASE) protein domain (PD000946) which is seen in DUT_LACLA.Residues 24-82 are 69% similar to a (DUTPASE DEOXYURIDINE NUCLEOTIDOHYDROLASE) protein domain (PD068009) which is seen in DUT_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 11:55:24 2002","Mon Jul 24 15:33:02 2006","Mon Jul 24 15:33:02 2006","Mon Jul 24 15:33:02 2006","Wed Jan 16 11:53:14 2002","Wed Jan 16 11:53:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0291 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 11:55:24 2002","","No significant hits to the NCBI PDB database.","SMU.325","","Residues 15 to 147 (E-value = 4.4e-12) place SMu0291 in the dUTPase family which is described as dUTPase (PF00692)","Wed Jan 16 11:53:14 2002","24378823","","","Persson R, Harkiolaki M, McGeehan J, Wilson KS.Crystallization and preliminary crystallographic analysis of deoxyuridine 5'-triphosphate nucleotidohydrolase from Bacillus subtilis.Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):876-8.PMID: 11375514","Mon Jul 24 15:33:02 2006","Mon Jul 24 15:33:02 2006","1","","","SMU.325","622" "SMu0292","307975","308445","471","ATGGCAGATTATTTATTAGTTATAGATATGCAGTCAGACTACGTTGCTGCTGGAAAAGCTTATGATAGTGAAGCGCTGACTGCGGCTGTTAATGACAAAATTGCTAGCTATTCAAGAGACCATGTGATTTATATAGTTAATCGTTTTTTCTGGGAATTAACAAGGAAACCGAAGAATTTTGCAATTGGCCTTTCCTTGGTGTCTGATAGAGTCTTTGAAAAGCGTCAAGCATCTTGCTTTACGAACCAAAACTTAACAAGATTTTTGGAGGAAAGCGGTGCAGAGAGTTTAGAATTTATTGGTGTTGATGGCAATGGTTGCGTCAATGCTTCAATTCTGGCAGCAGCACATAAGGGCTATCAAGTCTCAGTTGATTTATCCTATCTTGGCGTTATCAATAAGGAAAAATTTCAAAAGACACTGCAACAATGGCAGATTGCTGGAATAGTAACGAGAGGAGAATTACCATAG","5.80","-1.62","17378","MADYLLVIDMQSDYVAAGKAYDSEALTAAVNDKIASYSRDHVIYIVNRFFWELTRKPKNFAIGLSLVSDRVFEKRQASCFTNQNLTRFLEESGAESLEFIGVDGNGCVNASILAAAHKGYQVSVDLSYLGVINKEKFQKTLQQWQIAGIVTRGELP","308442","","conserved hypothetical protein","Cytoplasm","This sequence corresponds to the previously sequenced gi|15625450 in GenBank, an unknown. Additionally a weak similarity was observed to gi|15674036, a conserved hypothetical protein from L.lactis (gi|15674036).SMu0292 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000868
Family

Isochorismatase hydrolase
G3DSA:3.40.50.850	$\"[1-150]T$	Isochorismatase_hydro
SSF52499	$\"[1-152]T$	Iscrsm_hydrolase

noIPR
unintegrated

unintegrated
PTHR11080	$\"[33-150]T$	PTHR11080

","BeTs to 4 clades of COG1335COG name: Amidases related to nicotinamidaseFunctional Class:� RThe phylogenetic pattern of COG1335 is A--kyqv-EBr-----ol---Number of proteins in this genome belonging to this COG is 2","***** IPB000868 (Isochorismatase hydrolase family) with a combined E-value of 1.6e-12. IPB000868A 5-14 IPB000868C 79-133","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 12:16:08 2002","Wed Jan 16 12:16:08 2002","Wed Jan 16 12:16:08 2002","Wed Jan 16 12:14:08 2002","Wed Jan 16 12:14:08 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0292 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 12:16:08 2002","","No significant hits to the NCBI PDB database.","SMU.326","","No significant hits to the Pfam 11.0 database","Wed Jan 16 12:14:08 2002","24378824","","","","Wed Jan 16 12:16:08 2002","","1","","","SMU.326","" "SMu0293","308403","309803","1401","ATGGCAGATTGCTGGAATAGTAACGAGAGGAGAATTACCATAGCTAAGAAAAAAACAACTTTTGTCTGTCAAGAGTGCGGCTATAATTCGCCCAAGTATCTGGGACGTTGTCCTAATTGCTCGTCTTGGTCTTCTTTTGTTGAAGAGGTTGAAGTTGCTGAGGTTAAAAATGCTCGCGTTTCACTGACAGGTGAGAAGACACGGCCAGTCAAGTTAAATCAGGTCACCTCCAGCCAAGCCACTAGAGTCAAGACCAATATGGAAGAATTCAACCGTGTTTTGGGTGGTGGTGTTGTACCAGGCAGTCTGGTTCTTATCGGCGGTGATCCCGGCATCGGGAAATCGACCCTACTTTTGCAAGTTTCAACACAATTAGCCAATAAAGGAACTGTTTTTTATGTTTCTGGTGAAGAATCAGCGGAGCAGATCAAGTTGCGTAGCGAGCGTCTCGGTGATATTGACAATGAGTTTTATCTCTATGCTGAAACTAATATGCAAAGTATTCGTGCTGAGATTGAAAAAATCCAGCCTGATTTTTTAATTATTGATTCTATTCAAACAGTGATGAGTCCTGAAATTTCCAGTGTTCAAGGTTCTGTTTCTCAGGTGCGTGAAGTGACAGCAGAATTAATGCAATTAGCTAAAACCAATAACATTGCGACTTTTATTGTTGGACATGTGACTAAAGAAGGAACCTTAGCTGGACCGCGAATGTTAGAACACATGGTGGACACTGTGCTCTACTTTGAAGGCGAGCGGCAGCATACTTTTCGTATCTTACGAGCCGTTAAAAATCGCTTTGGTTCTACTAATGAGATTGGTATTTTTGAAATGAGGTCGGGTGGTTTGGTTGAGGTTTTGAATCCCAGCCAAGTTTTTTTAGAAGAGCGTCTAGATGGAGCAACAGGCTCAGCTATTGTTGTTACCATGGAAGGAACACGACCTATTTTAGCGGAAGTACAAGCCCTAGTAACACCAACTGTTTTTGGTAATGCTAAACGGACAACAACAGGACTGGACTTTAATCGTGTTAGTTTGATTATGGCGGTTTTGGAGAAGCGCTGCGGACTTTTATTGCAAAATCAAGATGCCTATCTCAAATCAGCTGGTGGTGTGCGCTTAGATGAGCCTGCTATTGATTTAGCGGTTGCGGTAGCCATTGCTTCCAGTTATAAGGAAAAGCCAACCACCCCTCAAGAATGTTATATTGGTGAAATTGGTTTGACAGGTGAAATTCGTCGTGTTAATCGTATCGAACAACGTCTCAATGAAGCTAGTAAGCTCGGTTTTACCAAGATTTTTGTACCCAAAAATTCCCTGTCAGGTTTAACGATTCCACAAGGTATTCAGGTAATTGGTGTGACAACTGTTAGTGAAGTCTTAAAAAAGGTATTTAATTGA","7.20","0.44","51098","MADCWNSNERRITIAKKKTTFVCQECGYNSPKYLGRCPNCSSWSSFVEEVEVAEVKNARVSLTGEKTRPVKLNQVTSSQATRVKTNMEEFNRVLGGGVVPGSLVLIGGDPGIGKSTLLLQVSTQLANKGTVFYVSGEESAEQIKLRSERLGDIDNEFYLYAETNMQSIRAEIEKIQPDFLIIDSIQTVMSPEISSVQGSVSQVREVTAELMQLAKTNNIATFIVGHVTKEGTLAGPRMLEHMVDTVLYFEGERQHTFRILRAVKNRFGSTNEIGIFEMRSGGLVEVLNPSQVFLEERLDGATGSAIVVTMEGTRPILAEVQALVTPTVFGNAKRTTTGLDFNRVSLIMAVLEKRCGLLLQNQDAYLKSAGGVRLDEPAIDLAVAVAIASSYKEKPTTPQECYIGEIGLTGEIRRVNRIEQRLNEASKLGFTKIFVPKNSLSGLTIPQGIQVIGVTTVSEVLKKVFN","309800","For other 'rad' genes see SMu0963 (radC). ","DNA repair protein","Cytoplasm","Several matches in gapped BLAST to DNA repair proteins. Residues 14-466 are 81% similar to gi|15674421 from S.pyogenes. Residues 56-485 are 85% similar to gi|15902069 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0110 (0.0).","

InterPro
IPR001984
Family

Peptidase S16, Lon protease
PR00830	$\"[108-127]T$ $\"[372-391]T$ $\"[402-421]T$ $\"[425-443]T$	ENDOLAPTASE

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[100-253]T$	AAA

InterPro
IPR004504
Family

DNA repair protein RadA
PR01874	$\"[23-47]T$ $\"[92-120]T$ $\"[133-150]T$ $\"[183-207]T$ $\"[222-250]T$ $\"[257-283]T$ $\"[331-354]T$	DNAREPAIRADA
TIGR00416	$\"[14-461]T$	sms

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[63-284]T$	G3DSA:3.40.50.300
SSF52540	$\"[63-288]T$	SSF52540
SSF54211	$\"[302-464]T$	SSF54211

","BeTs to 10 clades of COG1066COG name: Predicted ATP-dependent serine protease (Sms family)Functional Class: OThe phylogenetic pattern of COG1066 is -----Qvcebrhuj---linxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 71-191 are 63% similar to a (ATP-BINDING DNA-BINDING RECOMBINATION DAMAGE REPAIR) protein domain (PD000229) which is seen in Q9CDY7_LACLA.Residues 21-61 are 53% similar to a (REPAIR DNA HOMOLOG SMS) protein domain (PD007172) which is seen in Q9CDY7_LACLA.Residues 192-379 are 86% similar to a (REPAIR DNA HOMOLOG SMS) protein domain (PD007508) which is seen in Q9CDY7_LACLA.Residues 140-191 are 42% similar to a (REPAIR DNA) protein domain (PD381557) which is seen in Q9X8L5_STRCO.Residues 380-461 are 74% similar to a (REPAIR DNA HOMOLOG SMS) protein domain (PD007689) which is seen in Q9CDY7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 11:08:56 2002","Wed Jan 16 12:17:42 2002","Wed Jan 16 12:22:31 2002","Tue Apr 9 15:04:57 2002","","Wed Jan 16 12:17:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0293 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 12:22:31 2002","","No significant hits to the NCBI PDB database.","SMU.327","","No significant hits to the Pfam 11.0 database","Wed Jan 16 12:17:42 2002","24378825","","","","","","1","","","SMU.327","17" "SMu0294","309887","310387","501","ATGGTAATGTCTTATTTTGATAATTTTATAAAGGCAAATCAAGCATATGTTGATTTGCATGGAACCGCTCACTTGCCACTTAAGCCAAAAACGCGTGTTGCTATTGTTACTTGTATGGACTCTCGTTTACACGTAGCACCTGCTTTGGGGTTGGCTTTAGGAGATGCCCATATTTTACGCAATGCAGGCGGCCGTGTAACGGATGACGTTATTCGTTCTCTGGTTATTTCTGAGCAACAGTTAGGAACAAGTGAAATTGTGGTTTTGCATCATACGGATTGTGGTGCACAGACTTTTACAAATGCTGAGTTTACTGAGCAGTTAAAGCGGGATTTAGCTGTTGATGCTGGAGATCAGGACTTTCTTCCGTTTACAGATATTGAAGAGAGTGTGCGAGAGGATATTGCTCTTTTGAAAAATTCTCCTCTGATTCCTGAAGATATTATTATTTCTGGAGCTATTTATGATGTTGATACAGGACGAGTAAGAGAAGTCAATTAA","4.70","-9.65","18211","MVMSYFDNFIKANQAYVDLHGTAHLPLKPKTRVAIVTCMDSRLHVAPALGLALGDAHILRNAGGRVTDDVIRSLVISEQQLGTSEIVVLHHTDCGAQTFTNAEFTEQLKRDLAVDAGDQDFLPFTDIEESVREDIALLKNSPLIPEDIIISGAIYDVDTGRVREVN","310384","","conserved hypothetical protein; possible carbonic anhydrase","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins, e.g. residues 3-165 are 77% similar to gi15899971 from S.pneumoniae and 73% similar to gi15674422 from S.pyogenes. Residues 3-165 are 39% similar to gi15840732 from M.tuberculosis, a predicted carbonic anhydrase-related protein.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0111 (1e-74).","

InterPro
IPR001765
Domain

Carbonic anhydrase, prokaryotic and plant
G3DSA:3.40.1050.10	$\"[7-165]T$	CO_anhd_prok_pln
PF00484	$\"[26-166]T$	Pro_CA
SSF53056	$\"[5-166]T$	Prok_plnt_COanhd

","BeTs to 6 clades of COG0288COG name: Carbonic anhydraseFunctional Class: PThe phylogenetic pattern of COG0288 is --t-y--CEBRhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001765 (Prokaryotic-type carbonic anhydrase) with a combined E-value of 9.3e-09. IPB001765A 24-67 IPB001765B 69-93 IPB001765D 130-165","Residues 28-92 are 61% similar to a (CARBONIC ANHYDRASE LYASE PROTEOME) protein domain (PD331464) which is seen in Q9S2W3_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 12:27:58 2002","Mon Jul 24 15:46:01 2006","Mon Jul 24 15:46:01 2006","Tue Oct 8 08:43:14 2002","Wed Jan 16 12:23:07 2002","Wed Jan 16 12:23:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0294 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 12:27:58 2002","","No significant hits to the NCBI PDB database.","SMU.328","","Residues 26 to 166 (E-value = 3e-15) place SMu0294 in the Pro_CA family which is described as Carbonic anhydrase (PF00484)","Wed Jan 16 12:23:07 2002","24378826","","","","","","1","","","SMU.328","623" "SMu0295","310576","311289","714","ATGCCAGATAATCGCATGAACTATAGTATTGATAGCAATATGCAGTTTCCCTTGGTAGAAATTACTTTGGAAACAGGAGAATTTGCTTATATTCAACGCGGTAGCATGGTCTATCACACACCCAGTGTCACTCTCAATACCAAAGTCAATGGACGTGGTTCAGGACTTGGCAAGCTAGTAGGAGCAATTGGTCGTTCTGTAACGTCTGGAGAAAGTTTTTTCATTACTCAGGCAGTATCAAATGCTAGCGATGGTAAATTGGCCTTGGCCCCTTCTATGCCGGGCCAAGTTATTGCTTTAGAATTGGGAGAAAAACAATATCGCCTCAATGATGGTGCTTTTCTTGCCTTAGATGGTTCTGCTCAATATCAAATGAAAGCTCAGAGTGTTGGACGTGCCCTTTTTGGCGGTCAAGGCGGTCTTTTTGTTATGACAACAGAAGGTCAAGGTACCTTGCTTGCTAATAGTTTTGGTTCTATCAAAAAAATAGAATTACAGAATCAGGAAATTACAATTGACAATGCTCATGTTGTAGCTTGGAGTAGGGATTTGAACTATGACATTCATTTGGAAAATGGCTTTATGCAATCGATCGGAACCGGTGAAGGCGTTGTCAATACTTTCCGAGGAACGGGTGAAATTTATGTACAAAGTCTTAATCTGCAGCAGTTTGCTGGTGTCCTACAGGGTTTCATTACCAATACTAATCGTTAA","5.30","-3.28","25516","MPDNRMNYSIDSNMQFPLVEITLETGEFAYIQRGSMVYHTPSVTLNTKVNGRGSGLGKLVGAIGRSVTSGESFFITQAVSNASDGKLALAPSMPGQVIALELGEKQYRLNDGAFLALDGSAQYQMKAQSVGRALFGGQGGLFVMTTEGQGTLLANSFGSIKKIELQNQEITIDNAHVVAWSRDLNYDIHLENGFMQSIGTGEGVVNTFRGTGEIYVQSLNLQQFAGVLQGFITNTNR","311286","","conserved hypothetical protein","Extracellular","Matches in gapped BLAST to conserved hypothetical proteins, e.g. residues 6-236 are 77% similar to gi|15674423 from S.pyogenes. Residues 6-232 are 44% similar to gi|15672568 from L.lactis.SMu0295 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002838
Family

Protein of unknown function DUF124
PF01987	$\"[6-232]T$	DUF124
TIGR00266	$\"[6-236]T$	DUF124

noIPR
unintegrated

unintegrated
SSF51219	$\"[5-232]T$	TrpBP

","BeTs to 4 clades of COG2013COG name: Uncharacterized ACRFunctional Class:� SThe phylogenetic pattern of COG2013 is a-t---vC-------------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 17-218 are 46% similar to a (PROTEOME COMPLETE VNG2631H TA0740) protein domain (PD013634) which is seen in Q9CHY2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 12:30:53 2002","Wed Jan 16 12:30:53 2002","Wed Jan 16 12:30:53 2002","Wed Jan 16 12:30:53 2002","","Wed Jan 16 12:30:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0295 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 12:30:53 2002","","No significant hits to the NCBI PDB database.","SMU.329","","Residues 6 to 232 (E-value = 1.2e-81) place SMu0295 in the DUF124 family which is described as Protein of unknown function DUF124 (PF01987)","Wed Jan 16 12:30:53 2002","24378827","","","","","","1","","","SMU.329","" "SMu0296","311576","313033","1458","ATGACAAACAAAATTCGTGTGCGTTACGCACCAAGTCCAACAGGATTGTTACACATTGGAAATGCACGTACTGCGCTCTTTAATTATCTCTATGCGCGTCATCATGGTGGCGATTTTATCATTCGTATTGAAGATACGGACCGTAAGCGCCATGTTGAGGATGGGGAACGCTCCCAGCTTGAAAATCTGCGTTGGTTGGGCATGGATTGGGATGAAAGTCCTGAAACGCATGAAAATTATCGTCAATCAGAACGTTTAGCACTTTATAAAAAATACATTGACCAACTCTTGGCTGAAGGAAAAGCTTATAAATCTTATGTAACGGAAGAAGAATTAGCTGCAGAACGTGAACGTCAAGAAGCAGCTGGTGAAACACCTCGCTATATCAATGAATTTCTCGGTATGTCAGCAGATGAAAAGGCTGCCTACATCGCAAAACGGCAAGCAGCTGGTATTGTGCCAACGGTTCGTTTAAAAGTCAATGAAGCTGGTATTTATAAATGGCATGATATGGTTAAAGGTGATATTGAATTTGAAGGTGGCAATATTGGTGGTGACTGGGTTATCCAGAAGAAAGACGGTTACCCAACCTATAATTTTGCCGTTGTAGTGGACGATCATGACATGCAAATTTCTCATGTTATTCGTGGTGATGACCATATTGCCAATACGCCAAAACAACTCATGGTTTACGAAGCACTTGGTTGGGAAGCGCCAGCATTTGCTCACATGACTCTTATCATCAACTCAGAAACGGGAAAGAAACTATCCAAACGTGATACCAATACCCTACAATTTATCGAAGATTATCGTCAGAAAGGCTATCTGCCAGAAGCTGTTTTCAATTTCATCGCTCTTCTTGGTTGGAATCCTGGTGGGGAAAACGAAATTTTTTCACGTCAAGAATTGATTGAACTCTTTGATGAAAATCGTCTTAGCAAGTCACCAGCCGCCTTTGATCAGAAGAAATTGGACTGGATGAATAATGAATACATCAAAAATGCCGATTTTGATACGATTTTTGCTTTGGCAAAACCTTATTTAGAATCAGCTGGTCGTTTGACAGATAAGGCTAAAAAATTGGTTGAGCTCTATCAGCCACAGATGAAATCTATTGATGAAATTGTGCCTTTAACGGATCTTTTCTTTGAAGAGTTTCCAGAATTGTCAGAAGAGGAAAAAGAATTCATGGCTGGTGAAACAGTTCCAATTGTTCTCCAAGCCTTCAAGGCAAAATTGGAAGCCATGTCAGATGAAGATTTCAAATCGGAAAATATTTTTCCGCAAATTAAAGCCGTTCAAAAAGAAACGGGCATCAAGGGGAAAAATCTTTTCATGCCAATTCGTATTGCCGTTTCAGGTGAAATGCATGGGCCAGAATTACCAGATACAATCTTCTTACTAGGTAAGGAAAAATCCATTCAGCATCTTGAAGATATGCTTGAAAAATTGAAATAA","5.00","-18.03","55710","MTNKIRVRYAPSPTGLLHIGNARTALFNYLYARHHGGDFIIRIEDTDRKRHVEDGERSQLENLRWLGMDWDESPETHENYRQSERLALYKKYIDQLLAEGKAYKSYVTEEELAAERERQEAAGETPRYINEFLGMSADEKAAYIAKRQAAGIVPTVRLKVNEAGIYKWHDMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVVDDHDMQISHVIRGDDHIANTPKQLMVYEALGWEAPAFAHMTLIINSETGKKLSKRDTNTLQFIEDYRQKGYLPEAVFNFIALLGWNPGGENEIFSRQELIELFDENRLSKSPAAFDQKKLDWMNNEYIKNADFDTIFALAKPYLESAGRLTDKAKKLVELYQPQMKSIDEIVPLTDLFFEEFPELSEEEKEFMAGETVPIVLQAFKAKLEAMSDEDFKSENIFPQIKAVQKETGIKGKNLFMPIRIAVSGEMHGPELPDTIFLLGKEKSIQHLEDMLEKLK","313030","For other 'glt' genes see SMu0741 (gltS); SMu0330 (gltA),(gltB) and SMu0331 (gltD).","glutamyl-tRNA synthetase","Cytoplasm","Numerous matches in gapped BLAST to glu-tRNA synthetases. Residues 1-484 are 83% similar to gi|15901888 from S.pneumoniae. Residues 1-481 are 83% similar to gi|15674424 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0113 (0.0).","

InterPro
IPR000924
Family

Glutamyl-tRNA synthetase, class Ic
PR00987	$\"[8-20]T$ $\"[22-33]T$ $\"[37-50]T$ $\"[196-206]T$ $\"[212-220]T$	TRNASYNTHGLU
PTHR10119	$\"[8-485]T$	Glu_tRNA-synt_1c
PF00749	$\"[4-326]T$	tRNA-synt_1c

InterPro
IPR001412
Family

Aminoacyl-tRNA synthetase, class I
PS00178	$\"[11-22]T$	AA_TRNA_LIGASE_I

InterPro
IPR004527
Family

Glutamyl-tRNA synthetase bacterial/mitochondrial
TIGR00464	$\"[4-483]T$	gltX_bact

InterPro
IPR008925
Domain

Class I aminoacyl-tRNA synthetase, anticodon-binding
G3DSA:1.10.10.350	$\"[383-482]T$	tRNA_synt_bd
SSF48163	$\"[320-482]T$	tRNA-synt_bind

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[4-248]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
G3DSA:1.10.1160.10	$\"[250-336]T$	G3DSA:1.10.1160.10
PTHR10119:SF1	$\"[8-485]T$	PTHR10119:SF1
SSF52374	$\"[4-319]T$	SSF52374

","BeTs to 17 clades of COG0008COG name: Glutamyl- and glutaminyl-tRNA synthetasesFunctional Class: JThe phylogenetic pattern of COG0008 is amtkYqVcEbrHUJgpolinXNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 282-340 are 35% similar to a (LIGASE SYNTHETASE ATP-BINDING) protein domain (PD392320) which is seen in SYE2_THEMA.Residues 8-258 are 81% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA GLUTAMYL-TRNA) protein domain (PD001595) which is seen in Q9CDZ7_LACLA.Residues 361-483 are 58% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD002794) which is seen in Q9CDZ7_LACLA.Residues 314-359 are 65% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD188425) which is seen in Q9CDZ7_LACLA.Residues 270-312 are 67% similar to a (LIGASE SYNTHETASE ATP-BINDING) protein domain (PD325855) which is seen in SYE_BACST.Residues 263-307 are 84% similar to a (SYNTHETASE LIGASE GLUTAMYL-TRNA AMINOACYL-TRNA GLURS) protein domain (PD265942) which is seen in Q9CDZ7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 11:10:34 2002","Wed Jan 16 12:36:26 2002","Wed Jan 16 12:39:21 2002","Mon Apr 1 13:53:14 2002","","Wed Jan 16 12:36:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0296 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 12:39:21 2002","Wed Jan 16 12:36:26 2002","pdb|1GLN| Mol_id: 1; Molecule: Glutamyl-Trna Synthetase; Chai... 265 1e-071","SMU.330","","Residues 4 to 326 (E-value = 2.5e-165) place SMu0296 in the tRNA-synt_1c family which is described as tRNA synthetases class I (E and Q), catalytic domain (PF00749)","Wed Jan 16 12:36:26 2002","24378828","","","Pelchat M, Lapointe J.Aminoacyl-tRNA synthetase genes of Bacillus subtilis: organization and regulation.Biochem Cell Biol. 1999;77(4):343-7. Review.PMID: 10546897","","Wed Jan 16 12:54:36 2002","1","","","SMU.330","18" "SMu0297","313149","313673","525","ATGAAAGCAAAGGAACGTCGTCAGGCTATTTTAGAAAGGTTAGAAAAGACACAAGTTCCAATTTCAGCTGGGTATTTGGCCAAGGAATTGGGAGTTAGTCGTCAGATTATTGTGGGGGATATTGCTTTGTTACGAGCTGAAAATCATGATATTATGGCCACTCATCGAGGTTATCTTTTAGCTGAGCGTCTGCAAGTACCAAAGTCCTTCTACCATGGCAAACTTGTCTGTAAGCATGGGCCTAAGGAAGTCCGCTTGGAATTGGAGACCATTGTCAAAAACGGTGGTAAAATCTTAGATGTTGAAGTGGAGCACCCGATTTATGGCATGATTACTGCTCCTTTAAATATTGAGAATCAAGATGAAATTGATTATTTCATGGATAAGCTCTCTTGTTATAAAGGCAGCTTATTAAGCAGTTTGACAGATGGGATTCATTTACACACGCTTTCTTGTCGTGATAAAGAAACCTTTGAGAAAATCACTGAAGCGCTTGAGCAGGAGCATATCGTCTTTAATAATTAA","6.70","-1.21","19794","MKAKERRQAILERLEKTQVPISAGYLAKELGVSRQIIVGDIALLRAENHDIMATHRGYLLAERLQVPKSFYHGKLVCKHGPKEVRLELETIVKNGGKILDVEVEHPIYGMITAPLNIENQDEIDYFMDKLSCYKGSLLSSLTDGIHLHTLSCRDKETFEKITEALEQEHIVFNN","313670","","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Residues 1-172 are 50% similar to gi15675342 from S.pyogenes. Residues 4-168 are 41% similar to gi15644350 from T.maritima.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1603 (2e-44).","

InterPro
IPR004173
Domain

3H
PF02829	$\"[75-172]T$	3H

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[4-63]T$	Wing_hlx_DNA_bd

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[6-59]T$	HTH_11

noIPR
unintegrated

unintegrated
G3DSA:3.30.1340.20	$\"[68-172]T$	G3DSA:3.30.1340.20
SSF46785	$\"[1-63]T$	SSF46785
SSF75500	$\"[68-174]T$	SSF75500

","BeTs to 3 clades of COG1827COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1827 is --T---v--b-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-168 are 41% similar to a (PROTEOME CHANNEL COMPLETE RELATED) protein domain (PD101611) which is seen in Q9X1T8_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 11:10:59 2002","Wed Jan 16 12:58:15 2002","Tue Sep 19 09:52:35 2006","Tue Sep 19 09:52:35 2006","","Wed Jan 16 12:58:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0297 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 10 11:10:59 2002","","No significant hits to the NCBI PDB database.","SMU.331","","Residues 75 to 172 (E-value = 1.9e-25) place SMu0297 in the 3H family which is described as 3H domain (PF02829)","Wed Jan 16 12:58:15 2002","24378829","","","","","","1","","","SMU.331","963" "SMu0298","313740","314288","549","ATGTCTAGTTCTGGTTCATCTGTCATACGTAAACGTATCCAAAATCTGACATTATCAGCTGTTTTAACAGCTTTTAGCATTTTAATTCCGATGATTATGCCTGTTAAGGTGATTATTGGTCCGGCTTCCTTTACTTTAGCTAGTCATGTTCCTATTTTTATCGCTATGTTTCTTTCACCTGAAGTTGCTGTTATTGTTGCTTTGGGGACAAGTCTAGGCTTCTTTATAGCTGGTTTTCCTTTTGTTATTGTCATGCGTGCTTTGACCCATCTTATTTTTGCAGCTATTGGTGCTTATCTCATTCAAAAATACCCCAGCTTCTTAAAGAATTTTAAAAACTCTTTTCCTCTTGCCTTTGGACTCAATATTATTCATGGTCTGGGAGAATTTCTCGTTGTTTTACTATTGACAACTACTAATCAGCAATCGACTTCCTATTGGTTTACGTTGATTGTTTTAATTGGACTAGGTTCCCTGATTCATGGAATGATAGATTTCTATTTAGCCTATTATTGTTGGAAATTTTTGAAGAAAACAGGAAGAATTTAA","10.80","9.89","20028","MSSSGSSVIRKRIQNLTLSAVLTAFSILIPMIMPVKVIIGPASFTLASHVPIFIAMFLSPEVAVIVALGTSLGFFIAGFPFVIVMRALTHLIFAAIGAYLIQKYPSFLKNFKNSFPLAFGLNIIHGLGEFLVVLLLTTTNQQSTSYWFTLIVLIGLGSLIHGMIDFYLAYYCWKFLKKTGRI","314285","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 10-178 are 51% similar to gi|15675341 from S.pyogenes and 45% similar to gi|15903156 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1602 (7e-48).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-34]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[54-76]?$ $\"[81-101]?$ $\"[115-135]?$ $\"[150-170]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 10-178 are 43% similar to a (PROTEOME COMPLETE) protein domain (PD400141) which is seen in Q9CGD6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 13:03:59 2002","Wed Jan 16 13:00:53 2002","Wed Jan 16 13:03:59 2002","Wed Jan 16 13:00:53 2002","","Wed Jan 16 13:00:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0298 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 13:03:59 2002","","No significant hits to the NCBI PDB database.","SMU.332","","No significant hits to the Pfam 11.0 database","Wed Jan 16 13:00:53 2002","24378830","","","","","","1","","","SMU.332","962" "SMu0299","314437","315672","1236","ATGACAGAAGATATCAATAACGAAAATGTTCCAGAGGAAAATACCCCTAAAAATCCAACTGAGAGCAATTCAGTGTCAGGGGAGCAAACTGAGCAAGCAACAGATGCCAATCCAACAGCTGCGCCAGTTCTAGAGCAGGCTGTTGAAGGAGGAACTGCCAACCAAGAAATTCCTCAGCAAGCGCCAGTGCCTCCAACGGAATCAGTTGCTCCTCAAGGACAGCAAACAGCTTTTGAACAACAAGTTGCTTCGCCATTTACCAATCCAGTTAGTCCAACTGCACCAACTGTAACAGCTCGCAAGGAACTCATTGTTCTTCCGATTATTTCTTTCGTTGTTTCAGTTATTACACTTATTTTAGCTTGGTTTGCCCCACTACCAATTATCTATGTAATTATTGCCTTTCTTGGGCTTATCTATGCAATTGTGAGCTTAATTGTTAACATTCAACGTAAGAAAGTCTTATCAATTATTGCTCTAGTTTTGGCTTCTCTTATTTTCTTAGTCAGCGGGCTTGCTGTTTTTGTTCGTCAGGCCCAAAATAATCCGAATCCGACGGAACAAACAGAATCAAAGAAATCTGACGAAAAGGATGATACCGATGTTGACGATGATGATTCAAAAGACAGTACAGATGTTAAGGATTATATTGCAGATAGTTCGGATTTTAAATTTAAATGGACAAAGTCTAAATTTACTGACTTAAAATTTTCTAGCTATTCTAATAAAAATGGGGATAGCTTAAAATCAGTTGTTAAAAAGTTTGGTAAGGGATCTAATGCTACTATTTCTGGTGAAAGTTTAAATTTGGAATACAGAAAAAGCGGTGACGACGATGAACGAGAAAGTGTGCACCTAATTTTTAGAAAGCAATATAATGGTAAATTTATTCTTTCGGATGGTTATGCTTATTTTACTTCTAAAGATATAAAGACTGTTTCTGAAAAATCTTATAAGTCTGACTGGACACAAGCAGATGTTGATGCTTTAACAGTTGGTGATTCTAGTACTGGAAAGGGTGGAGATAATTTAAATGAAGTTCTTAAAAAGCATGGAAATCCGACTGAAGCTAGAGAATCAATCTCAAATTATGGTGATAGCTTTAAAACAAGCTTGAAAATTTTTTACAATTCTAATGCTTCTAATGACAGTTCTAAGTTAGGTTATGTCTCTTTAGAATTTGCACAGCAATCTAATGATGATTATCTATTAACTTATAAATACCCTACGAAATAA","4.60","-14.48","45108","MTEDINNENVPEENTPKNPTESNSVSGEQTEQATDANPTAAPVLEQAVEGGTANQEIPQQAPVPPTESVAPQGQQTAFEQQVASPFTNPVSPTAPTVTARKELIVLPIISFVVSVITLILAWFAPLPIIYVIIAFLGLIYAIVSLIVNIQRKKVLSIIALVLASLIFLVSGLAVFVRQAQNNPNPTEQTESKKSDEKDDTDVDDDDSKDSTDVKDYIADSSDFKFKWTKSKFTDLKFSSYSNKNGDSLKSVVKKFGKGSNATISGESLNLEYRKSGDDDERESVHLIFRKQYNGKFILSDGYAYFTSKDIKTVSEKSYKSDWTQADVDALTVGDSSTGKGGDNLNEVLKKHGNPTEARESISNYGDSFKTSLKIFYNSNASNDSSKLGYVSLEFAQQSNDDYLLTYKYPTK","315669","","conserved hypothetical protein","Membrane, Periplasm, Extracellular","Two very weak similarities in gapped BLAST: residues 321-407 are 40% similar to residues 171-253 of gi14251157 from Lactococcus phage BK5-T. Residues 100-153 are 38% similar to residues 4-57 of gi13095745 from L.lactis bacteriophage bIL286.This sequence is similar to Str0518.SMu0299 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[103-123]?$ $\"[129-149]?$ $\"[154-176]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 321-407 are 40% similar to a (ORF258) protein domain (PD122232) which is seen in Q38326_VVVVV.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 20 13:41:08 2007","Tue Feb 20 13:41:08 2007","Tue Feb 20 13:41:08 2007","Wed Jan 16 13:08:09 2002","","Wed Jan 16 13:08:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0299 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 20 13:41:08 2007","","No significant hits to the NCBI PDB database.","SMU.333","","No significant hits to the Pfam 11.0 database","Wed Jan 16 13:08:09 2002","24378831","","","","","","1","","","SMU.333","" "SMu0300","315869","317059","1191","ATGTCAAAAGAGAAAGTTATTTTAGCTTATTCAGGCGGACTTGATACGTCAGTTGCCATTACGTGGTTAAAAAAAGATTATGATGTTGTTGCTGTTTGTATGGATGTTGGTGAAGGTAAAGATCTTGAGTTTATTCATGATAAAGCGCTGAAAGTTGGAGCAATTGAATCTTATGTCTTGGATATTAAAGATGAATTTGCTGAAGAATATGTCCTTCCTGCTCTGCAGGCTCATGCTTATTATGAACAAAAATATCCATTAGTATCAGCCCTTAGTCGTCCAGTGATTTCTAAGAAATTGGTTGAAATTGCTCATCAGACAGGAGCAACTACTATTGCTCATGGCTGTACCGGTAAGGGAAATGATCAAGTTCGGTTTGAAGTAGCTATTGCAGCACTTGATCCAAAATTAAAAGTCATTGCACCTGTTCGGGAGTGGAAATGGTCACGGGAAGAAGAGATTAATTATGCTAAAGAAAATGGCGTACCGGTTCCGGCTGATCTTGATAATCCTTACTCTGTTGATCAAAATCTTTGGGGCCGTGCAAATGAATGCGGTGTCCTTGAAAATCCTTGGAACCAAGCTCCAGAAGAGGCGTTTGGTATCACCAATTCGGTTGAAGAAGCTCCAGATAAAGCAGAATACGTTGATATTACATTTAAAGAAGGCAAGCCTGTTGCTCTTGATGGACAGGAAATGAAGTTGGCTGATCTTATTCAAAAGCTTAATGTTCTTGCTGGTAAGCATGGTGTTGGTCGAATTGATCATGTTGAAAATCGTTTAGTTGGTATTAAATCACGTGAAATTTACGAATGTCCCGGGGCAGTTACTCTTTTAACAGCTCATAAGGAAATTGAGGATATAACCTTAGTGCGTGAGGTGTCGCACTTCAAGCCGATTCTTGAAAATGAATTGTCAAATCTTATCTACAATGCTCTTTGGTTCAATCCAGCAACGCAAGCTATTCTTGCTTATATTACGGAAACACAAAAAGAAGTTAATGGAACAGCTAAAGTGAAATTGTACAAGGGATCTGCAAGGGTTGTTGCTAGAAAGTCACCTCATTCACTTTATGATGAAAATTTAGCAACCTATACATCAGCTGATAGTTTTGATCAAGATGCAGCCGTTGGTTTCATTAAACTTTGGGGATTACCAACGCAAGTTAACTCACAGGTAAACAACAAATAA","5.10","-12.98","43900","MSKEKVILAYSGGLDTSVAITWLKKDYDVVAVCMDVGEGKDLEFIHDKALKVGAIESYVLDIKDEFAEEYVLPALQAHAYYEQKYPLVSALSRPVISKKLVEIAHQTGATTIAHGCTGKGNDQVRFEVAIAALDPKLKVIAPVREWKWSREEEINYAKENGVPVPADLDNPYSVDQNLWGRANECGVLENPWNQAPEEAFGITNSVEEAPDKAEYVDITFKEGKPVALDGQEMKLADLIQKLNVLAGKHGVGRIDHVENRLVGIKSREIYECPGAVTLLTAHKEIEDITLVREVSHFKPILENELSNLIYNALWFNPATQAILAYITETQKEVNGTAKVKLYKGSARVVARKSPHSLYDENLATYTSADSFDQDAAVGFIKLWGLPTQVNSQVNNK","317056","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0607 (argB);SMu0608 (argD); SMu1904 (argS);SMu1903 (argR); SMu1900 (argR); SMu0238 (argF) and SMu0301 (argH).","argininosuccinate synthase","Cytoplasm","Numerous matches in gapped BLAST to argininosuccinate synthases. Residues 1-393 are 87% similar to the enzyme from S.pneumoniae (gi15902146). Residues 1-396 are 70% similar to the enzyme from L.monocytogenes (gi16804129).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0125 (0.0).","

InterPro
IPR001518
Family

Argininosuccinate synthase
PTHR11587	$\"[1-396]T$	Arginosuc_synth
PF00764	$\"[7-393]T$	Arginosuc_synth
TIGR00032	$\"[5-395]T$	argG
PS00564	$\"[9-17]T$	ARGININOSUCCIN_SYN_1
PS00565	$\"[115-126]T$	ARGININOSUCCIN_SYN_2

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[4-171]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
G3DSA:3.90.1260.10	$\"[172-396]T$	G3DSA:3.90.1260.10
SSF52402	$\"[1-170]T$	SSF52402
SSF69864	$\"[171-395]T$	SSF69864

","BeTs to 10 clades of COG0137COG name: Argininosuccinate synthaseFunctional Class: EThe phylogenetic pattern of COG0137 is amt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001518 (Argininosuccinate synthase) with a combined E-value of 8.1e-122. IPB001518A 8-19 IPB001518B 26-38 IPB001518C 40-82 IPB001518D 89-127 IPB001518E 170-186 IPB001518F 213-226 IPB001518G 243-286 IPB001518H 308-317 IPB001518I 333-344","Residues 7-391 are 70% similar to a (LIGASE ARGININOSUCCINATE SYNTHASE) protein domain (PD003544) which is seen in ASSY_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 11 08:53:03 2006","Tue Jul 11 08:53:03 2006","Tue Jul 11 08:53:03 2006","Wed Apr 3 09:30:08 2002","Wed Jan 16 13:10:06 2002","Wed Jan 16 13:10:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0300 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 13:18:28 2002","","No significant hits to the NCBI PDB database.","SMU.334","","Residues 7 to 393 (E-value = 2.7e-232) place SMu0300 in the Arginosuc_synth family which is described as Arginosuccinate synthase (PF00764)","Wed Jan 16 13:10:06 2002","24378832","","","Lemke C, Yeung M, Howell PL.Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli argininosuccinate synthetase.Acta Crystallogr D Biol Crystallogr. 1999 Dec;55 ( Pt 12):2028-30.PMID: 10666579","","Wed Jan 16 13:18:28 2002","1","","","SMU.334","19" "SMu0301","317402","318784","1383","ATGACAACAAAAAATCACAAATTATGGGGCGGCAGATTTGAAGCTGGTTTAGCACAGTGGGTTGAGGAATTTGGAGCTTCCATTTCCTTTGATCAAAAATTGGCAGAATTTGATCTCAAGGGTTCTATTGCTCATGTTACCATGTTAGGGGAAAAAGGAATTATTTCTCAAGAAGATGCCGCAACAATCAAAGCAGGTTTAGAAGACTTGTTAGAAGAATATAAAGCTGGACAATTGAAATTTGATGTTTCCAATGAAGATATTCATATGAATATGGAAAGTCTTCTGACTGCTAAAATTGGTCCTGTGGCAGGCAAGCTTCACACGGCTCGTTCGAGAAATGATCAGGTAGCGACAGATATGCATCTTTACTTGAAAGCTAAGTTGGATGAGGTGATTGAAAAGTTAGCTAACTTGCGTACTGTCTTAGTTGACTTGGCAGATAAGCATGTTCATACTATTATGCCAGGCTATACCCATTTACAGCATGCTCAGCCTATTTCTTTTGGCCATCACCTTATGGCTTATTACAACATGTTTACCCGAGACAGTGAACGTTTTATTTTTAATGTTAAGCATACAGACTTGTCTCCGCTGGGAGCAGCTGCTTTGGCAGGTACGACCTTTCCAATTGATCGTGAGATGACAGCACAGCTTATGGGGTTTGCCGAACCTTACAGCAATTCACTAGATGCAGTATCTGATCGTGATTTTATCTTAGAATTTTTATCGAATGCTTCTATTCTTATGATGCATATGAGCCGTATGTGTGAAGAAGTCATTAGTTGGTGCTCTCATGAGTATCAATTTGTAACGCTTTCAGATACGTTTTCAACCGGCTCATCCATCATGCCGCAAAAGAAAAATCCTGACATGGCAGAGCTCATTCGTGGAAAGTCAGGACGTGTTTATGCTAATCTTTTTGGACTTTTGACTGTTATGAAAGCTCTGCCTTTGGCTTATAACAAAGATCTTCAAGAAGATAAGGAAGGTATGTTTGATACTGCTGAAACGATTACAGTTGCTCTTGACATTTTGGCTGGTATGCTATCTAGTATGATTGTTAATGACAAACATATGGCTGAATCAACTCAAAAAGATTTTTCTAATGCAACAGAATTGGCTGATTATTTAGCCAGCAAAGGCATGCCCTTTCGTCAGGCCCATGAGATTGTTGGGAAATTAATCCTTGAATGCAGTAAGAATGGTCATTATTTGCAAGATGTTCCTCTTGAACGTTATCAAACCATTTCTGACTTAATTGAGGAAGATGTCTATGAAACACTTAAATCACATACGGCCGTTGAGCGACGTCATTCTCTTGGCGGAACTGGTTTTGAACAGGTTAAATGGCAGATTGCAGAGGCTAAAAAAGCACTTTAA","5.60","-14.53","51490","MTTKNHKLWGGRFEAGLAQWVEEFGASISFDQKLAEFDLKGSIAHVTMLGEKGIISQEDAATIKAGLEDLLEEYKAGQLKFDVSNEDIHMNMESLLTAKIGPVAGKLHTARSRNDQVATDMHLYLKAKLDEVIEKLANLRTVLVDLADKHVHTIMPGYTHLQHAQPISFGHHLMAYYNMFTRDSERFIFNVKHTDLSPLGAAALAGTTFPIDREMTAQLMGFAEPYSNSLDAVSDRDFILEFLSNASILMMHMSRMCEEVISWCSHEYQFVTLSDTFSTGSSIMPQKKNPDMAELIRGKSGRVYANLFGLLTVMKALPLAYNKDLQEDKEGMFDTAETITVALDILAGMLSSMIVNDKHMAESTQKDFSNATELADYLASKGMPFRQAHEIVGKLILECSKNGHYLQDVPLERYQTISDLIEEDVYETLKSHTAVERRHSLGGTGFEQVKWQIAEAKKAL","318781","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0607 (argB);SMu0608 (argD); SMu1904 (argS);SMu1903 (argR); SMu1900 (argR); SMu0238 (argF) and SMu0300 (argG).","argininosuccinate lyase","Cytoplasm","Several matches in gapped BLAST to arginosuccinate lyase proteins. Residues 4-459 are 74% similar to gi|15902147 from S.pneumoniae. Residues 7-460 are 70% similar to gi|15672107 from L.lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0126 (0.0).","

InterPro
IPR000362
Domain

Fumarate lyase
PR00149	$\"[107-125]T$ $\"[152-168]T$ $\"[236-263]T$ $\"[280-296]T$	FUMRATELYASE
PF00206	$\"[11-305]T$	Lyase_1
PS00163	$\"[280-289]T$	FUMARATE_LYASES

InterPro
IPR003031
Domain

Delta crystallin
PR00145	$\"[106-128]T$ $\"[147-167]T$ $\"[198-214]T$ $\"[236-260]T$ $\"[280-296]T$ $\"[315-334]T$	DCRYSTALLIN

InterPro
IPR008948
Domain

L-Aspartase-like
SSF48557	$\"[20-460]T$	L-Aspartase-like

InterPro
IPR009049
Domain

Argininosuccinate lyase
TIGR00838	$\"[8-460]T$	argH

noIPR
unintegrated

unintegrated
PTHR11444	$\"[1-460]T$	PTHR11444
PTHR11444:SF3	$\"[1-460]T$	PTHR11444:SF3

","BeTs to 9 clades of COG0165COG name: Argininosuccinate lyaseFunctional Class: EThe phylogenetic pattern of COG0165 is amt-yq-cebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000362 (Fumarate lyase) with a combined E-value of 2.1e-17. IPB000362A 157-170 IPB000362B 280-290","Residues 182-303 are 59% similar to a (LYASE FUMARATE HYDRATASE COMPLETE) protein domain (PD000660) which is seen in Q9JVG7_NEIMA.Residues 307-453 are 68% similar to a (LYASE ARGININOSUCCINATE BIOSYNTHESIS) protein domain (PD040372) which is seen in ARLY_LACLA.Residues 39-170 are 30% similar to a (LYASE ADENYLOSUCCINATE ASL BIOSYNTHESIS) protein domain (PD408312) which is seen in PUR8_METJA.Residues 39-176 are 24% similar to a (LYASE HYDRATASE FUMARATE COMPLETE) protein domain (PD002097) which is seen in Q9YAX9_AERPE.Residues 8-114 are 64% similar to a (LYASE ARGININOSUCCINATE BIOSYNTHESIS) protein domain (PD002682) which is seen in ARLY_LACLA.Residues 201-306 are 78% similar to a (LYASE ARGININOSUCCINATE BIOSYNTHESIS) protein domain (PD254540) which is seen in ARLY_LACLA.Residues 181-425 are 46% similar to a (LYASE ADENYLOSUCCINATE BIOSYNTHESIS) protein domain (PD328331) which is seen in ARLY_RAT.Residues 119-171 are 54% similar to a (LYASE ARGININOSUCCINATE BIOSYNTHESIS ARGINOSUCCINASE) protein domain (PD403746) which is seen in Q9K821_BACHD.Residues 115-176 are 69% similar to a (LYASE ARGININOSUCCINATE ARGININE) protein domain (PD406599) which is seen in ARLY_LACLA.Residues 26-114 are 38% similar to a (LYASE ARGININOSUCCINATE PROTEOME) protein domain (PD292399) which is seen in Q9HMQ3_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 16:02:47 2002","Thu Apr 25 15:56:43 2002","Tue Oct 22 16:02:47 2002","Wed Apr 3 09:30:49 2002","Fri Dec 7 13:29:53 2001","Fri Dec 7 13:29:53 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0301 is paralogously related (blast p-value < 1e-3) to SMu0054,a predicted adenylosuccinate lyase.","Wed Jan 16 13:35:25 2002","Fri Dec 7 13:29:53 2001","pdb|1AOS|A Chain A, Human Argininosuccinate Lyase >gi|2914652|p... 376 4e-105pdb|1AUW|A Chain A, H91n Delta 2 Crystallin From Duck >gi|29817... 370 2e-103pdb|1DCN|D Chain D, Inactive Mutant H162n Of Delta 2 Crystallin... 332 4e-092","SMU.335","","Residues 11 to 305 (E-value = 1.8e-84) place SMu0301 in the Lyase_1 family which is described as Lyase (PF00206)","Fri Dec 7 13:29:53 2001","24378833","","","Yu B, Howell PL.Intragenic complementation and the structure and function of argininosuccinate lyase.Cell Mol Life Sci. 2000 Oct;57(11):1637-51. Review.PMID: 11092456Cohen-Kupiec R, Kupiec M, Sandbeck K, Leigh JA.Functional conservation between the argininosuccinate lyase of the archaeon Methanococcus maripaludis and the corresponding bacterial and eukaryal genes.FEMS Microbiol Lett. 1999 Apr 1;173(1):231-8.PMID: 10220900","","Fri Dec 7 13:38:51 2001","1","","","SMU.335","20" "SMu0302","318879","319238","360","TTGAAAAAAGCCTATCGCGTTAAAAGTGATAAAGATTTTCAGGCAATTTTTACTGAAGGACGAAGTGTTGCCAATCGGAAATTTGTTGTCTATAGTTTAGAAAAAGATCAAAGTCACTATCGTGTTGGACTTTCAGTTGGAAAAAGATTAGGAAATGCTGTCGTTAGAAATGCGATTAAACGAAAATTGCGCCATGTCCTTATGGAACTTGGTCCTTATTTAGGCACTCAAGATTTTGTTGTTATTGCTAGAAAAGGTGTTGAGGAACTTGATTATAGCACGATGAAAAAAAATCTGGTTCATGTTTTAAAACTGGCTAAACTGTATCAGGAAGGATCTATTCGTGAAAAAGAAATATAG","10.90","12.71","13693","MKKAYRVKSDKDFQAIFTEGRSVANRKFVVYSLEKDQSHYRVGLSVGKRLGNAVVRNAIKRKLRHVLMELGPYLGTQDFVVIARKGVEELDYSTMKKNLVHVLKLAKLYQEGSIREKEI","319235","","ribonuclease P protein component","Cytoplasm, Extracellular","Matches in gapped BLAST to ribonuclease P protein sequences. Residues 1-118 are 61% similar to gi15674428 from S.pyogenes and 62% similar to gi15903895 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0408 (9e-41).","

InterPro
IPR000100
Family

Bacterial ribonuclease P protein
PD003629	$\"[8-100]T$	RNPA_STRMU_Q8DVX4;
PF00825	$\"[1-107]T$	Ribonuclease_P
TIGR00188	$\"[1-110]T$	rnpA: ribonuclease P protein component
PS00648	$\"[50-64]T$	RIBONUCLEASE_P

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[1-115]T$	no description

noIPR
unintegrated

unintegrated
PIRSF001011	$\"[1-114]T$	Bacterial ribonuclease P, protein component

","BeTs to 9 clades of COG0594COG name: RNase P protein componentFunctional Class: LThe phylogenetic pattern of COG0594 is ------vcebrhujgpo-inxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 33-116 are 30% similar to a (COMPONENT RNA-BINDING NUCLEASE TRNA) protein domain (PD264005) which is seen in RNPA_HELPY.Residues 1-104 are 60% similar to a (RNASE COMPONENT RNA-BINDING NUCLEASE) protein domain (PD338325) which is seen in RNPA_LACLA.Residues 1-107 are 46% similar to a (RIBONUCLEASE COMPONENT RNA-BINDING TRNA) protein domain (PD231568) which is seen in RNPA_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 13:46:08 2002","Wed Jan 16 13:37:06 2002","Thu Sep 7 10:45:42 2006","Thu Sep 7 10:45:42 2006","","Wed Jan 16 13:37:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0302 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 13:46:08 2002","Thu Sep 7 10:45:42 2006","pdb1A6F Rnase P Protein From Bacillus Subtilis 105 2e-024pdb1D6TA Chain A, Rnase P Protein From Staphylococcus Aureus 101 3e-023pdb1D6TA Chain A, Rnase P Protein From Staphylococcus Aureus 179 9e-047","SMU.336","","Residues 1 to 107 (E-value = 4.2e-30) place SMu0302 in the Ribonuclease_P family which is described as Ribonuclease P (PF00825)","Wed Jan 16 13:37:06 2002","24378834","","","Tanaka T, Baba H, Hori Y, Kikuchi Y.Guide DNA technique reveals that the protein component of bacterial ribonuclease P is a modifier for substrate recognition.FEBS Lett. 2001 Feb 23;491(1-2):94-8.PMID: 11226427Spitzfaden C, Nicholson N, Jones JJ, Guth S, Lehr R, Prescott CD, Hegg LA, Eggleston DS.The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA.J Mol Biol. 2000 Jan 7;295(1):105-15.PMID: 10623511Niranjanakumari S, Stams T, Crary SM, Christianson DW, Fierke CA.Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA.Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15212-7.PMID: 9860948","","Wed Jan 16 13:46:08 2002","1","","","SMU.336","898" "SMu0303","319222","320037","816","GTGAAAAAGAAATATAGAATTATTGGATTAGCTGTTGCAGCACTTTTGTTTTTATCGGCTTGTGGACGTAGTCAAGTTACCAGTCATTCAAGCGATGCTTGGGAGAAGTTTGTTTATTTCTTTGCGGAGACCATCCGCTTTTTATCCATCAATGGCAGGATTGGTATCGGAATTATTCTCTTTACCTTTCTTATCAGAACCATTCTTTTACCACTGTTTAACTTGCAATTGAAATCTGGACAAAAAATGCAGGAGCTTCAGCCTGAGCTGAAAGCTTTACAGACTAAATATCCGGGTAAAGACAGGGAAAGCCGTATGCGTATGGCTGAGGAAAGTCAGGAACTTTACAAAAAATATGGTGTCAATCCCTATGCCAGCCTTTTTCCTCTTCTTATTCAGATGCCCGTTCTTTGGGCTCTCTATCAAGCCCTTACTCGAGTTGAATTTTTAAAAACAGGGTCTTTTCTTTGGATGGATATTGGCAATAAAGATCCTTACTTTATCTTACCTGTCTTGGCAGCTATTTTTACTTTCTTATCTTCTTGGCTGACTAATAAGGCCGCCAAAGAACGAAATGGTATGATGATAACGATGAACATTATCTTACCGATCTTTATCTTGCTTATTGGCTTTAATTTAGCCAGTGGGGTTGCTCTCTACTGGGTAGTCTCAAATGCTTATCAGGTCTTCCAGATTCTGTTGTTAAATAATCCCTTTAAAATTATTGCAGAACGCCAGCGTCTTGAAGATGAAGCACGTGAATTGGAAGCTAAGAAAAGACGTGCTAAAAAGAAAGCACATAAAAAGAGAAAATAA","10.90","20.43","31280","MKKKYRIIGLAVAALLFLSACGRSQVTSHSSDAWEKFVYFFAETIRFLSINGRIGIGIILFTFLIRTILLPLFNLQLKSGQKMQELQPELKALQTKYPGKDRESRMRMAEESQELYKKYGVNPYASLFPLLIQMPVLWALYQALTRVEFLKTGSFLWMDIGNKDPYFILPVLAAIFTFLSSWLTNKAAKERNGMMITMNIILPIFILLIGFNLASGVALYWVVSNAYQVFQILLLNNPFKIIAERQRLEDEARELEAKKRRAKKKAHKKRK","320034","","inner membrane protein","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypothetical proteins and SpoIIIJ family proteins. Residues 1-242 are 57% similar to gi15674429 from S.pyogenes and 54% similar to gi15672111 from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0409 (1e-72).","

InterPro
IPR001708
Family

60 kDa inner membrane insertion protein
PR00701	$\"[119-142]T$ $\"[203-226]T$	60KDINNERMP
PTHR12428	$\"[55-249]T$	OXA1
PF02096	$\"[52-240]T$	60KD_IMP

noIPR
unintegrated

unintegrated
PTHR12428:SF11	$\"[55-249]T$	OXAA 1, 2
signalp	$\"[1-24]?$	signal-peptide
tmhmm	$\"[7-27]?$ $\"[53-73]?$ $\"[125-145]?$ $\"[164-184]?$ $\"[193-211]?$ $\"[217-235]?$	transmembrane_regions

","BeTs to 12 clades of COG0706COG name: Inner membrane proteins, SpoIIIJ familyFunctional Class: SThe phylogenetic pattern of COG0706 is ----yqvceBrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** PR00701 (60Kd inner membrane protein signature) with a combined E-value of 3.3e-15. PR00701G 119-142 PR00701H 164-186 PR00701I 203-226","Residues 71-238 are 38% similar to a (MEMBRANE COMPLETE PROTEOME INNER) protein domain (PD002157) which is seen in SP3J_BACSU.Residues 71-235 are 59% similar to a (TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD409339) which is seen in Q9CJ72_LACLA.Residues 1-52 are 53% similar to a (PROTEOME COMPLETE YBDC) protein domain (PD385775) which is seen in Q9CJ72_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 14:03:32 2002","Wed Jul 26 11:18:22 2006","Wed Jul 26 11:18:22 2006","Thu Apr 25 15:59:33 2002","Wed Jan 16 13:57:30 2002","Wed Jan 16 13:57:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0303 is paralogously related (blast p-value < 1e-3) to SMu1573, a possible inner membrane protein.","Wed Jan 16 14:03:32 2002","","No significant hits to the NCBI PDB database.","SMU.337","","Residues 52 to 240 (E-value = 2.4e-50) place SMu0303 in the 60KD_IMP family which is described as 60Kd inner membrane protein (PF02096)","Wed Jan 16 13:57:30 2002","24378835","","","","","","1","","","SMU.337","645" "SMu0304","320050","321018","969","ATGGTATTATTCACAGGAAAAACTGTTGAAGAAGCTATTGAAAGTGGTTTGAAACAAATGGGTATTTCTCGTATGAAGGCTCATATTAGAGTGATCTCGCGGGAGAAAAAGGGCTTTCTGGGTTTTGGCAGAAAACTAGCTCGAGTCGAAATTGAAGGAATTAATGAAAAGACAGCCCATAAGGCTGATCAAAAGGCAGTACGTGGTGTACCGGATAGTATTAATAAGCAAAATGCTCCTGTTTCAAGCAGTGCTGAAGATACGGTGGCTTTAAATCATCTGTCAAAAACTATTAAAAAATTAGAAAAAGAAGATGGTCAACCATTAGATAAAGAGATCAAAGAACAAGTCTTAGAGCATAAGATTTCTGCACAAGAAATGTTAGAGCAAAATGCTTTAACAACTAAAACATCGGCAGCCACTGCTTCTAGTGAAGCCTTCAATCAAAAAGGAAAGCAAACTTTTGAGGACTTTGTTGCTGATGCATTTGATGAAGTTGATAATGGTGCAGATATTGCTGTGGCGAGTAAAGAAGTTTCTCAATACATCCAAAAAATTATTTATGAAATGGATCTAGAAACAAGCATTGAGACAAGTCATAATCGTCGTCAAATCAATCTTCAAATTGAAACGCCAGAGGCAGGACGTGTTATCGGTTATCATGGCAAGGTTTTAAAATCATTGCAATTGTTAGCACAAAACTTTTTACATGATCATTATTCAAAACATTTTTCCGTCACTTTAAATGTTCATGATTATATGGAACATCGGACAAAAATACTTATTGATTTTGCACATAAAATTGCTAAACGTGTCTTAGATTCCGGTAAGGCTTATCAGATGGATCCCATGAGTAATAGTGAGAGGAAGGTTATTCATAAAACAATTACTGGCATTGAAGGAGTTGAAAGTTATTCTGAAGGCAATGATCCCAATCGTTATGTTGTTATTGCGTCGAAGGGCAATTAA","7.50","2.16","36006","MVLFTGKTVEEAIESGLKQMGISRMKAHIRVISREKKGFLGFGRKLARVEIEGINEKTAHKADQKAVRGVPDSINKQNAPVSSSAEDTVALNHLSKTIKKLEKEDGQPLDKEIKEQVLEHKISAQEMLEQNALTTKTSAATASSEAFNQKGKQTFEDFVADAFDEVDNGADIAVASKEVSQYIQKIIYEMDLETSIETSHNRRQINLQIETPEAGRVIGYHGKVLKSLQLLAQNFLHDHYSKHFSVTLNVHDYMEHRTKILIDFAHKIAKRVLDSGKAYQMDPMSNSERKVIHKTITGIEGVESYSEGNDPNRYVVIASKGN","321015","","conserved hypothetical protein, Jag protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-318 are 58% similar to gi15674430 from S.pyogenes and 49% similar to gi15901861 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0410 (3e-83).","

InterPro
IPR001374
Domain

Single-stranded nucleic acid binding R3H
PF01424	$\"[265-320]T$	R3H
PS51061	$\"[255-321]T$	R3H

InterPro
IPR009019
Domain

KH, prokaryotic type
SSF54814	$\"[177-229]T$	KH_prok

noIPR
unintegrated

unintegrated
SSF82708	$\"[260-320]T$	SSF82708

","BeTs to 6 clades of COG1847COG name: Predicted RNA-binding proteins, Jag familyFunctional Class: RThe phylogenetic pattern of COG1847 is ------vc-br-----ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 174-317 are 34% similar to a (PROTEOME COMPLETE JAG SPOIIIJ-ASSOCITATED) protein domain (PD008360) which is seen in Q9CJ71_LACLA.Residues 177-317 are 33% similar to a (JAG PROTEOME COMPLETE ASSOCIATED) protein domain (PD407648) which is seen in Q9X1H1_THEMA.Residues 1-119 are 43% similar to a (PROTEOME COMPLETE YBDD) protein domain (PD398581) which is seen in Q9CJ71_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 14:01:01 2002","Wed Jul 26 14:38:31 2006","Wed Jul 26 14:38:31 2006","Wed Jul 26 14:38:31 2006","","Wed Jan 16 13:58:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0304 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 14:01:01 2002","","No significant hits to the NCBI PDB database.","SMU.338","","Residues 266 to 316 (E-value = 1.4e-13) place SMu0304 in the R3H family which is described as R3H domain (PF01424)","Wed Jan 16 13:58:11 2002","24378836","","","","","","1","","","SMU.338","646" "SMu0305","321128","321730","603","ATGTTGCTCACTATTTTTAGTATTTTAGCCATCTTATGCCTTGTTCTGTACTTTTATTGTATGGTAATTTTGCACCTAAAAAATAAAGGCGTTTATCACCCCATGACTCATGCAGTCAGTGATTATGGTATCGGACAGAATAAATCTTATTTTCAACTGGCAGGTTTAGCTAATACCTTTAGAAATCTTTTTTTAATTCTATCACTGATTTTCTGGAAGTATTCTTTTTCTTTTAAAAAGGAAGCTGTCTTATTGCTCATCTTGGCTATCATTGGTTATGCAGGGGTAGCGCTATTTCCGACAGATATTGAAGGTAGCAAACGAACAGTCAAAGGGATTATTCATTTACTTTTTGCTATTTTACAATTTACGGCCTTGGCAATATTTATTTTTAATGTTACAGAAGTTCTTAAACCTTTGAATGCCACTTTATTTTTGATAGCATCTTATATCAAAATAGTTGTGGAAGTAGGACTATACGGTTTGGTCATTGCTTTATTCTTACCTTTTGTTAAAAAATATTTTGGCCTTTTTGAACGTCTTTTCCTCTATTCAAGTAACCTTTATATCTTGTTGCTTTGTGTTATGATGATTAGATATTGA","10.30","9.80","22810","MLLTIFSILAILCLVLYFYCMVILHLKNKGVYHPMTHAVSDYGIGQNKSYFQLAGLANTFRNLFLILSLIFWKYSFSFKKEAVLLLILAIIGYAGVALFPTDIEGSKRTVKGIIHLLFAILQFTALAIFIFNVTEVLKPLNATLFLIASYIKIVVEVGLYGLVIALFLPFVKKYFGLFERLFLYSSNLYILLLCVMMIRY","321727","","hypothetical protein","Membrane, Cytoplasm","No significant matches in gapped BLAST.SMu0305 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-26]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[50-72]?$ $\"[82-100]?$ $\"[114-134]?$ $\"[144-166]?$ $\"[180-198]?$	transmembrane_regions

InterPro
IPR000271
Family

Ribosomal protein L34
PD003101	$\"[1-26]T$	Q8DVX0_STRMU_Q8DVX0;
PF00468	$\"[1-44]T$	Ribosomal_L34
TIGR01030	$\"[1-44]T$	rpmH_bact: ribosomal protein L34
PS00784	$\"[2-21]T$	RIBOSOMAL_L34

","BeTs to 11 clades of COG0230COG name: Ribosomal protein L34Functional Class: JThe phylogenetic pattern of COG0230 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000271 (Ribosomal protein L34) with a combined E-value of 2.5e-28. IPB000271 2-39","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 11:20:56 2002","Wed Jan 16 15:47:46 2002","Wed Jan 16 15:53:29 2002","Thu Apr 4 13:34:48 2002","Wed Jan 16 15:47:46 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0306 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 15:53:29 2002","","No significant hits to the NCBI PDB database.","SMU.340","","Residues 1 to 44 (E-value = 1e-18) place SMu0306 in the Ribosomal_L34 family which is described as Ribosomal protein L34 (PF00468)","Wed Jan 16 15:47:46 2002","24378838","","","","","","1","","","SMU.340","1022" "SMu0307","322265","323164","900","ATGCATAAGAGGGGACAGACAGCTATTATTTTTCATTTTCAAAGGGGGGCTGTACTAAAATCAGCTCCATTATCTCACTCAGTGAACCATAATATTTTATTTAGCATATGTTATAATGATAGTATGCTACAAATATTTGATACTCACACCCACCTTAACGTGGAAGATTTTACTGGAAAAGAACAAGAAGAAATTAACTTTGCGCATGAACTCGGCGTGACCAAGATGAACATTGTTGGTTTTGACCAATCAACCATTAAGCGTGCTCTTGAATTGGCTGAGCTCTACCCAGAACTCTATGCAACTATCGGCTGGCACCCGACTGAAGCTGGTTCCTACATGCAGGAAGTGGAGGACATGATTGTCAGCCATCTGCATGACCCTAAAGTTATCGCTCTCGGCGAAATTGGGCTAGATTACCACTGGATGGAAGATCCTAAAGAAGTACAGATCGAGGTTTTCAAGCGCCAGATTCAGTTATCCAAAGACCATGACCTGCCCTTTGTTGTTCACACCCGTGATGCTTTAGATGATACTTATGAGATTATCAAAGAAGCGGGAGTTGGTCCGCGCGGTGGCATCATGCATTCTTACTCAGGCTCTTTGGAAATGGCAGAGCGTTTCATAGATTTGGGCATGATGATTTCATTTTCTGGCGTGGTCACCTTTAAGAAGGCTCTGGATGTCCAAGAGGCTGCGCAGCATTTACCATTGGATAAAATCTTGGTCGAAACCGACGCACCCTATCTTGCTCCTGTACCCAAACGTGGCCGTAAAAATCATACTGCCTATACTCGCTATGTTGTAGACAAAATCGCAGAGCTTCGCGGTCTCACGATCGAAGAAGTTGCCCAAGCCACCTACGACAATGCTATGAGACTATTCAGATTGAAAGACTAG","5.80","-10.18","34009","MHKRGQTAIIFHFQRGAVLKSAPLSHSVNHNILFSICYNDSMLQIFDTHTHLNVEDFTGKEQEEINFAHELGVTKMNIVGFDQSTIKRALELAELYPELYATIGWHPTEAGSYMQEVEDMIVSHLHDPKVIALGEIGLDYHWMEDPKEVQIEVFKRQIQLSKDHDLPFVVHTRDALDDTYEIIKEAGVGPRGGIMHSYSGSLEMAERFIDLGMMISFSGVVTFKKALDVQEAAQHLPLDKILVETDAPYLAPVPKRGRKNHTAYTRYVVDKIAELRGLTIEEVAQATYDNAMRLFRLKD","323161","For other 'yab' genes see SMu0737 (yabB).","conserved hypothetical protein (possible deoxyribonuclease)","Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypotheticals and to hydrolases and possible deoxyribonucleases. Residues 33-297 are 74% similar to gi|15674440 from S. pyogenes. Residues 45-297 are 42% similar to YABD_BACSU, a potential deoxyribonuclease.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1782 (1e-117).","

InterPro
IPR001130
Family

TatD-related deoxyribonuclease
PTHR10060	$\"[68-297]T$	TatD_DNase
PF01026	$\"[43-296]T$	TatD_DNase
TIGR00010	$\"[45-297]T$	TatD_DNase
PS01091	$\"[232-248]T$	TATD_3
PS01137	$\"[45-53]T$	TATD_1

InterPro
IPR012278
Family

Mg-dependent DNase, TatD
PIRSF005902	$\"[45-299]T$	DNase_TatD

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.140	$\"[45-295]T$	G3DSA:3.20.20.140
SSF51556	$\"[41-297]T$	SSF51556

","BeTs to 16 clades of COG0084COG name: Predicted hydrolases of PHP superfamilyFunctional Class: RThe phylogenetic pattern of COG0084 is -mtkYqvcEbrHujgpoLinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001130 (Uncharacterized protein family UPF0006) with a combined E-value of 3.9e-39. IPB001130A 45-53 IPB001130B 99-107 IPB001130C 130-140 IPB001130D 150-173 IPB001130E 236-256","Residues 43-198 are 53% similar to a (COMPLETE PROTEOME HYDROLASE 3.1.21.-) protein domain (PD002155) which is seen in Q9CHP1_LACLA.Residues 209-249 are 87% similar to a (PROTEOME COMPLETE DEOXYRIBONUCLEASE 3.1.21.- HYDROLASE) protein domain (PD403160) which is seen in Q9CHP1_LACLA.Residues 254-295 are 50% similar to a (PROTEOME COMPLETE DEOXYRIBONUCLEASE) protein domain (PD403810) which is seen in YABD_BACSU.Residues 207-249 are 48% similar to a (HYDROLASE PROTEOME COMPLETE) protein domain (PD413810) which is seen in Q9ZCP1_RICPR.Residues 217-296 are 33% similar to a (RIBOSOMAL 40S S3A) protein domain (PD393203) which is seen in P90989_CAEEL.Residues 250-297 are 54% similar to a (PROTEOME COMPLETE YGII) protein domain (PD411079) which is seen in Q9CHP1_LACLA.Residues 250-295 are 54% similar to a (PROTEOME COMPLETE NMA0982 PA2959) protein domain (PD405837) which is seen in Q9JV60_NEIMA.Residues 250-297 are 50% similar to a (HYDROLASE NUCLEASE DEOXYRIBONUCLEASE) protein domain (PD393927) which is seen in YH86_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 11:21:22 2002","Thu Oct 10 11:21:22 2002","Wed Jan 16 15:58:26 2002","Thu Apr 4 14:38:04 2002","Wed Jan 16 15:54:18 2002","Wed Jan 16 15:54:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0307 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 15:58:26 2002","","No significant hits to the NCBI PDB database.","SMU.341","","Residues 43 to 297 (E-value = 9.7e-118) place SMu0307 in the TatD_DNase family which is described as TatD related DNase (PF01026)","Wed Jan 16 15:54:18 2002","24378839","","","","","","1","","","SMU.341","477" "SMu0308","323332","323967","636","ATGAAACCAAAGGTTTGCTTGCGTCCATGCTACCTTAGGCAAGCTGTCAAAAAAATAGAATTTATGACAGAAAAAATCAAAATACAAGAAGTCCTCGTCGTCGAAGGCAAAGACGACACCGTCAATCTACGTCGCTTTTATGATGTAGATACATACGAAACCAGAGGATCAGCTATCAATGATGAAGATTTAGAGCGCATCGAAAAACTCAATAATCTGCGCGGAGTTATCGTATTTACTGATCCAGACTATAATGGCGAACGCATTCGCAAGCTGATTATGACAGCTGTTCCGACCGCTAAACATGCTTTTCTCAATCGCGGTGAAGCAGTGCCTAAGTCCAAAACTAAAGGTCGTTCGCTGGGCGTTGAACATGCCTCTTTTGAAGATTTGCAAAAGGCTTTGTCTGGTGTTTTGGGTAACTATGATGATGAAAATCATTTTGATATTAGCAAGTCCGACCTTATGCGCTTTGGTCTTCTCATGGGAGCTGATAGCCGCAAGCGCCGTGAGTATATTGGGGAAAAACTGCGTATAGGCTACAGCAATGGCAAACAGCTGCTTAAACGCTTGGAACTCTTTGGAATTACTAAGGCGGAAGTTGAAGAAGTAATGGAAAAGTATCAAAAAAGATAG","9.90","6.64","24350","MKPKVCLRPCYLRQAVKKIEFMTEKIKIQEVLVVEGKDDTVNLRRFYDVDTYETRGSAINDEDLERIEKLNNLRGVIVFTDPDYNGERIRKLIMTAVPTAKHAFLNRGEAVPKSKTKGRSLGVEHASFEDLQKALSGVLGNYDDENHFDISKSDLMRFGLLMGADSRKRREYIGEKLRIGYSNGKQLLKRLELFGITKAEVEEVMEKYQKR","323964","","possible primase-related protein","Cytoplasm","Matches in gapped BLAST to largely hypothetical proteins. Residues 22-210 are 81% similar to gi15674441 from S.pyogenes. Residues 25-209 are 70% similar to gi15901813, a predicted primase-related protein from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1781 (3e-82).","

InterPro
IPR004466
Family

Primase-related protein
TIGR00334	$\"[27-206]T$	primaseG_like

InterPro
IPR006154
Domain

Toprim subdomain
SM00493	$\"[29-102]T$	TOPRIM

InterPro
IPR006171
Domain

TOPRIM
PF01751	$\"[29-106]T$	Toprim

","BeTs to 3 clades of COG1658COG name: Small primase-like proteins (Toprim domain)Functional Class: LThe phylogenetic pattern of COG1658 is amtk-q---B----gpo----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 114-205 are 45% similar to a (PROTEOME COMPLETE METS-KSGA BH0056) protein domain (PD407500) which is seen in Q9CHN9_LACLA.Residues 25-105 are 67% similar to a (DNA PRIMASE 2.7.7.- TRANSFERASE) protein domain (PD002276) which is seen in Q9CHN9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Aug 18 16:46:19 2006","Fri Aug 18 16:46:19 2006","Fri Aug 18 16:46:19 2006","Fri Aug 18 16:46:19 2006","","Wed Jan 16 16:02:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0308 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Aug 18 16:46:19 2006","","No significant hits to the NCBI PDB database.","SMU.342","","Residues 29 to 106 (E-value = 1.3e-05) place SMu0308 in the Toprim family which is described as Toprim domain (PF01751)","Wed Jan 16 16:02:06 2002","24378840","","","","","","1","","","SMU.342","729" "SMu0309","324244","324765","522","ATGACAGCTTTTTACCTACTAGTTCCTTTCCTGTTTATCAGATTTATTTTTCTCTCACTCTTGGATAGGAAAGCAACGGGGCGGGCAGCCCATTTTGCTTCGATGCAGGGAAAAGAAATAATAGCTTACTATCTTTATCAATTATCTACCCTTATGCTCCTGATTGTTCCTTTCTTTCTAAAAGTCAGTCTTCATTTCTCTAGTTTTTTCTATTTAGGGTTGGGTGCCTATCTCTTAGGTAGTGTGCTTCTTTTTTTGGTCATAAAGGATTTTGCCAACCCTGATGAAAAAGGATTGAATACCAAAGGGCTCTATGCTCTGTCCCGTCACCCAATGTATATTGCTTATTTTGTTTTATTTTTAGGCGTGGCGATGCTGACTCAGTCGTTAACACTGCTCATTTTCTTAGCGATTTTTCAACTATCAGCTCACTTTATCATACTGGCAGAGGAAAGAGAGTGTTTAATAAAATTTGGCGCTGCCTATCAAGAATACCAAAAACGAGTTAGGATGTATCTGTGA","10.30","6.90","19946","MTAFYLLVPFLFIRFIFLSLLDRKATGRAAHFASMQGKEIIAYYLYQLSTLMLLIVPFFLKVSLHFSSFFYLGLGAYLLGSVLLFLVIKDFANPDEKGLNTKGLYALSRHPMYIAYFVLFLGVAMLTQSLTLLIFLAIFQLSAHFIILAEERECLIKFGAAYQEYQKRVRMYL","324762","","conserved hypothetical protein","Membrane, Cytoplasm, Extracellular","All matches are weak: e.g., residues 101-173 are 37% similar to a fragment of gi|22966182, an hypothetical protein from Rhodospirillum rubrum. Other limited weak similarities in gapped BLAST are to bacterial hypotheticals. Residues 98-169 are 38% similar to residues 61-132 of gi|11499964 from Archaeoglobus fulgidus. Residues 99-173 are 36% similar to residues 70-145 of gi|15603878 from P.multocida.SMu0309 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PTHR12714	$\"[95-169]T$	PTHR12714

","BeTs to 5 clades of COG2020COG name: Putative protein-S-isoprenylcysteine methyltransferaseFunctional Class:� OThe phylogenetic pattern of COG2020 is a--ky--C--Rh---------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 98-169 are 38% similar to a (PROTEOME COMPLETE) protein domain (PD084689) which is seen in O30283_ARCFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 16:07:20 2002","Mon Oct 28 17:30:10 2002","Mon Oct 28 17:30:10 2002","Wed Jan 16 16:06:17 2002","","Wed Jan 16 16:06:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0309 is paralogously related (blast p-value < 1e-3) to SMu0206, a conserved hypothetical, and to SMu0756, a hypothetical.","Wed Jan 16 16:07:20 2002","","No significant hits to the NCBI PDB database.","SMU.343","","No significant hits to the Pfam 11.0 database","Wed Jan 16 16:06:17 2002","24378841","","","","","","1","","","SMU.343","" "SMu0310","324866","325123","258","ATGGCTTATCTTAGGGGGATTTTGGAGTTTACAGGTTTGCAGTCTGTTCAAACTTATATTCAGAGTGGTAACATCATCTGTGAGACGGATTTGTCGGATGAAAAGTTTAATCAGCTCATTGACGATACTATTAAAATCAAGCCCAACGCCCAACTGGTGCAGATTGCTGCGGAGCAATCTTTTGATGACAGCTTCGACATCTCACGCATACCAATGATGTTTGGCCTTCGGAACTTTCCTGAACCTAATTATTCGTAA","4.10","-6.06","9679","MAYLRGILEFTGLQSVQTYIQSGNIICETDLSDEKFNQLIDDTIKIKPNAQLVQIAAEQSFDDSFDISRIPMMFGLRNFPEPNYS","325120","","hypothetical protein","Cytoplasm","No significant matches in gapped BLAST.SMu0310 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR012545
Family

Protein of unknown function DUF1697
PF08002	$\"[1-26]T$	DUF1697

InterPro
IPR002577
Domain

Helix-turn-helix, HxlR type
PF01638	$\"[17-104]T$	DUF24
PS51118	$\"[9-104]T$	HTH_HXLR

noIPR
unintegrated

unintegrated
SSF46785	$\"[6-104]T$	SSF46785

","BeTs to 5 clades of COG1733COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1733 is Amt----ceBR----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 18-103 are 32% similar to a (PROTEOME COMPLETE YVAP CSPC-NAP) protein domain (PD004032) which is seen in Q9CKY0_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 16:13:49 2002","Thu Oct 10 11:59:16 2002","Wed Jan 16 16:13:49 2002","Tue Oct 8 08:46:15 2002","","Wed Jan 16 16:13:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0311 is paralogously related (blast p-value < 1e-3) to SMu1928, a conserved hypothetical protein.","Wed Jan 16 16:13:49 2002","","No significant hits to the NCBI PDB database.","SMU.345c","","Residues 17 to 104 (E-value = 1.7e-07) place SMu0311 in the DUF24 family which is described as Transcriptional regulator (PF01638)","Wed Jan 16 16:13:02 2002","24378843","","","","","","1","","","SMU.345c","" "SMu0312","325540","326157","618","ATGATGAATGATTATTTGAATTTCTTAGATGGACGCGTATCAGTCAGACAATTTGATCCTGATGCAGTCCTGCCAAATGATCTTATCAAGGATATGTTAGAGCATGCCAGCTATGCTCCGTCTGGTAATAATTTTCAACCTTGGCGCGTTGTGGTTGTGAAAAATAAAAACAAACAAGAAGATCTGAAAAAACTGGCAGCCCTTCAGCCGCAAGTTGCAACTGCGTCAGCAGTATTTCTCTTATTTGGGGATGAAAATGCCTATGATTTGACTTGGTGGCAGGAATTTCATGTGCAAAAAGGTATTATCACGAAAGATGAAGCAGCAGCGCGAGCTGAACGGATTCGTCAGTACTTTGACCTGCACCCTGAGGATAAGGAGACTCAGGGTTTACGATTAGATGTTGGGCTCTTTGCTATGAATCTCATGCAGGTTGTGAGGGTTTACGGCTATGATAGTGTGCCTATGCGTGGCGTGGATTTTGATGCTATTAAAACCTATCTTGACATGCCGAATGAATGGGAACCTATTTTGATGCTGCCGGTGGGAAAAGCATTGCAGGCAGGCAATCCGCATGTGAGAAAGTCTGTTGCAGAATTTGCAGAGATTATTGAATAA","4.90","-7.03","23429","MMNDYLNFLDGRVSVRQFDPDAVLPNDLIKDMLEHASYAPSGNNFQPWRVVVVKNKNKQEDLKKLAALQPQVATASAVFLLFGDENAYDLTWWQEFHVQKGIITKDEAAARAERIRQYFDLHPEDKETQGLRLDVGLFAMNLMQVVRVYGYDSVPMRGVDFDAIKTYLDMPNEWEPILMLPVGKALQAGNPHVRKSVAEFAEIIE","326154","","NADH dehydrogenase; NAD(P)H nitroreductase","Cytoplasm","Several hits to NADH dehydrogenases/nitroreductases. Residues 3-202 are 31% similar to YDGI_BACSU. Residues 3-199 are 30% similar to gi16799228 from L.inocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1220 (2e-09).","

InterPro
IPR000415
Family

Nitroreductase
PF00881	$\"[9-184]T$	Nitroreductase

noIPR
unintegrated

unintegrated
G3DSA:3.40.109.10	$\"[3-204]T$	G3DSA:3.40.109.10
PIRSF000232	$\"[3-203]T$	NADHdh_nitroRD
PTHR23026	$\"[35-204]T$	PTHR23026
PTHR23026:SF43	$\"[35-204]T$	PTHR23026:SF43
SSF55469	$\"[2-204]T$	SSF55469

","BeTs to 8 clades of COG0778COG name: Nitroreductase family proteinsFunctional Class: CThe phylogenetic pattern of COG0778 is AmT--qVcEBRHUJ-------Number of proteins in this genome belonging to this COG is 3","***** IPB000415 (Nitroreductase family) with a combined E-value of 2.4e-09. IPB000415A 40-52 IPB000415B 141-159","Residues 132-196 are 36% similar to a (OXIDOREDUCTASE COMPLETE PROTEOME) protein domain (PD036524) which is seen in Q9K673_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 16:21:37 2002","Wed Jan 16 16:15:30 2002","Tue Feb 20 13:46:38 2007","Tue Feb 20 13:46:38 2007","Wed Jan 16 16:15:30 2002","Wed Jan 16 16:15:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0312 is paralogously related (blast p-value < 1e-3) to SMu1135, and SMu1457, both predicted nitroreductases.","Wed Jan 16 16:22:43 2002","Tue Feb 20 13:46:38 2007","pdb1NOX Nadh Oxidase From Thermus Thermophilus 66 4e-012","SMU.346","","Residues 9 to 184 (E-value = 2.6e-30) place SMu0312 in the Nitroreductase family which is described as Nitroreductase family (PF00881)","Wed Jan 16 16:15:30 2002","24378844","","","","","","1","","","SMU.346","" "SMu0313","326257","326703","447","ATGTGCCTCATTTGTGAGCGGATTGATAGGATTAAATCAAGAACCAATCCTTATTTTGTTAAAGAATTAGAAACTGGTTATGTTGTTGTTGGCGATCATCAGCATTTCAAAGGGTATACGATTTTTCTTTGTAAGAAGCATGTGACAGAGCTTCACGACTTGCCCAAAGACTTTCGTGATAAGCATTTGTCTGAAATAGCAGACGTATCACAGGCAGTCAGTGCAGCATTTTCAGCTGAAAAAATGAATATCGAAAGTTTGGGAAATGGTGATAGTCATCTGCATTGGCACCTTTTTCCAAGAAAAACTGGTGATTTAGGAAATCATGGTTGCAAGGGTAAAGGTCCTGTTTGGTGGCTGCCTTTTGAGGAGATGTATGCGGTTAAAGCAAGTTCTTCTGAGATAGAAGAATTGAAAGATCAACTTTTACAACACTTACCGAAATAG","7.00","0.00","16959","MCLICERIDRIKSRTNPYFVKELETGYVVVGDHQHFKGYTIFLCKKHVTELHDLPKDFRDKHLSEIADVSQAVSAAFSAEKMNIESLGNGDSHLHWHLFPRKTGDLGNHGCKGKGPVWWLPFEEMYAVKASSSEIEELKDQLLQHLPK","326700","","histidine triad (HIT) hydrolase","Cytoplasm","Several hits in gapped BLAST to HIT-family proteins. Residues 1-148 are 62% similar to >gi|15900535 from S.pneumoniae. Residues 50-145 are 32% similar to gi|15642075 from V.cholerae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0370 (2e-04).","

InterPro
IPR001310
Family

Histidine triad (HIT) protein
PIRSF000714	$\"[1-148]T$	HIT
PF01230	$\"[16-104]T$	HIT
PS51084	$\"[6-108]T$	HIT_2

noIPR
unintegrated

unintegrated
G3DSA:3.30.428.10	$\"[16-105]T$	G3DSA:3.30.428.10
SSF54197	$\"[1-147]T$	SSF54197

","BeTs to 8 clades of COG0537COG name: Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolasesFunctional Class:� F,G,RThe phylogenetic pattern of COG0537 is amTKYQ-cebRhUJgpo-inxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 16:32:59 2002","Wed Jan 16 16:23:28 2002","Wed Jan 16 16:32:59 2002","Wed Jan 16 16:23:28 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0313 is paralogously related (blast p-value < 1e-3) to SMu0373, also a predicted HIT-related protein.","Wed Jan 16 16:33:54 2002","","No significant hits to the NCBI PDB database.","SMU.348","","No significant hits to the Pfam 11.0 database","Wed Jan 16 16:23:28 2002","24378845","","","","","","1","","","SMU.348","" "SMu0314","326715","327590","876","ATGAAAATCGCAGACAAAACCGTTACTCGCGCGATTTTGGAGCGCCACGGGTTCACGTTTAAGAAATTATTTGGTCAGAATTTTTTGACCGATACCAATATCTTGCAGAAGATTGTGGATACGGCTGAGATTGACAAAACTGTCAATGTCATTGAGATTGGTCCTGGCATTGGTGCTCTGACCGAATTTTTGGCGGAGAATGCCGCTGAGGTTATGGCTTTTGAGATTGATGATCGTCTCGTTCCGATTTTGGCGGATACGCTGCGCGATTTTGACAATATCAAAGTGGTCAATGAAGATATTCTCAAGTCCGACTTGCAGACACGTATCAAGGAATTTGCCAATCCTGACCTGCCTATCAAGGTGGTAGCCAATCTACCTTACTACATCACGACGCCTATCCTCATGCACCTGATTGAGAGTAAAATTCCTTTTGCGGAGTTTGTGGTTATGATGCAAAAAGAGGTGGCAGACCGCATTTCAGCTCAGCCAAGTACCAAGGCTTATGGGTCTTTGTCAATCGCTGTGCAGTATTACATGACGGCTAAGATTGCTTTCATTGTGCCACGTACCGTCTTTGTGCCAGCACCCAATGTTGATTCAGCCATTCTTAAGATGACCCGCCGTGAACAACCGCTGGTGCAAGTGCAGGATGAAGATTTCTTCTTCTGCGTCGGCAAAGCTGCCTTTGTCCACCGCCGTAAAACCCTCTGGAACAATCTCACCAGCCACTTTGGCAAATCAGAAGAGGTCAAAGTCAAGCTGGAACAAGCCTTGGAAGCAGCAGACATCAAACCATCTATTCGTGGTGAAGAACTGACGATTACAGACTTTGCCAGATTGGCAGATGCTCTACGAGAAGTTGATTTGAAATGA","5.60","-4.06","32803","MKIADKTVTRAILERHGFTFKKLFGQNFLTDTNILQKIVDTAEIDKTVNVIEIGPGIGALTEFLAENAAEVMAFEIDDRLVPILADTLRDFDNIKVVNEDILKSDLQTRIKEFANPDLPIKVVANLPYYITTPILMHLIESKIPFAEFVVMMQKEVADRISAQPSTKAYGSLSIAVQYYMTAKIAFIVPRTVFVPAPNVDSAILKMTRREQPLVQVQDEDFFFCVGKAAFVHRRKTLWNNLTSHFGKSEEVKVKLEQALEAADIKPSIRGEELTITDFARLADALREVDLK","327587","","dimethyladenosine transferase","Cytoplasm","Matches in gapped BLAST to dimethyladenosine transferases. Residues 1-290 are 84% similar to gi15674442 from S.pyogenes. Residues 1-286 are 80% similar to gi15459484 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1779 (1e-142).","

InterPro
IPR001737
Family

Ribosomal RNA adenine methylase transferase
PTHR11727	$\"[11-290]T$	RRNA_meth_trans
PF00398	$\"[17-287]T$	RrnaAD
SM00650	$\"[34-210]T$	rADc
PS01131	$\"[50-77]T$	RRNA_A_DIMETH

InterPro
IPR011530
Family

RRNA 16S rRNA dimethylase
TIGR00755	$\"[18-285]T$	ksgA

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.100	$\"[213-289]T$	G3DSA:1.10.8.100
G3DSA:3.40.50.150	$\"[26-212]T$	G3DSA:3.40.50.150
PIRSF000392	$\"[1-291]T$	KsgA
SSF53335	$\"[26-287]T$	SSF53335

","BeTs to 17 clades of COG0030COG name: Dimethyladenosine transferase (rRNA methylation)Functional Class: JThe phylogenetic pattern of COG0030 is amtkyqvcebRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001737 (Ribosomal RNA adenine dimethylase) with a combined E-value of 2.1e-40. IPB001737A 35-80 IPB001737B 122-135 IPB001737C 188-209","Residues 123-177 are 92% similar to a (TRANSFERASE DIMETHYLADENOSINE COMPLETE) protein domain (PD000922) which is seen in Q9CHN8_LACLA.Residues 186-281 are 31% similar to a (RESISTANCE TRANSFERASE METHYLTRANSFERASE RRNA PLASMID) protein domain (PD332330) which is seen in KSGA_MYCCA.Residues 21-103 are 32% similar to a (TRANSFERASE RRNA N-6-METHYTRANSFERASE) protein domain (PD407131) which is seen in O65090_ARATH.Residues 10-105 are 45% similar to a (TRANSFERASE RESISTANCE COMPLETE PROTEOME) protein domain (PD353410) which is seen in Q9RU68_DEIRA.Residues 25-108 are 41% similar to a (METHYLTRANSFERASE MYCINAMICIN-RESISTANCE) protein domain (PD351173) which is seen in Q54377_STRLN.Residues 93-210 are 29% similar to a (RESISTANCE METHYLTRANSFERASE RRNA) protein domain (PD034239) which is seen in ERMK_BACLI.Residues 24-86 are 73% similar to a (TRANSFERASE RESISTANCE METHYLTRANSFERASE RRNA ADENINE) protein domain (PD000786) which is seen in Q9CHN8_LACLA.Residues 239-285 are 55% similar to a (PROTEOME METHYLTRANSFERASE KASUGAMYCIN) protein domain (PD380930) which is seen in Q9CHN8_LACLA.Residues 188-237 are 74% similar to a (TRANSFERASE DIMETHYLADENOSINE PROTEOME) protein domain (PD355268) which is seen in Q9CHN8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 16:39:27 2002","Wed Jan 16 16:35:05 2002","Wed Sep 27 12:27:54 2006","Wed Sep 27 12:27:54 2006","Wed Jan 16 16:35:05 2002","Wed Jan 16 16:35:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0314 is paralogously related (blast p-value < 1e-3) to SMu1797, a conserved hypothetical.","Wed Jan 16 16:40:20 2002","Wed Sep 27 12:27:54 2006","pdb1QANA Chain A, The Structure Of The Rrna Methyltransferase... 85 1e-017pdb1YUB Solution Structure Of An Rrna Methyltransferase (Er... 73 4e-014","SMU.349","","Residues 17 to 287 (E-value = 3.9e-72) place SMu0314 in the RrnaAD family which is described as Ribosomal RNA adenine dimethylase (PF00398)","Wed Jan 16 16:35:05 2002","24378846","","","","","","1","","","SMU.349","476" "SMu0315","327600","328004","405","ATGACTAAGCCCAAACTAATCACTGCTTTCTGCGCTGTTCTTTACTTCATACAAGCTTTCCTTCATTTCTTGATTTTGTTAGGATTGCCTTTGGGTGGTTTCTTTTTCGGAGGACTTTACACGGTCTTTCCGCTTTGGCTAAGACCAGCCAATCTCTTTTTCGCCCTGATTTGGTCATTTTTTGCTTATTTTTACTTGATCTATGGGCAAATTCTTCCAAGCCGCTGGCCCAAAGCAAAGCTGAATCTCGTCATGGTAACAATGACAGGGCTGTCTTTATTAGCAACCGTTTTTAATCTTTTTATCAGCAGCAGCCCGCTTGAAAAGTATGGCACAGGCAGTATGACAGCTTTGACCTTCTTGCTAGGTTGCTGCCTGCTTGTCTTATCAAAAAAATCTCGCTAA","10.70","9.07","15098","MTKPKLITAFCAVLYFIQAFLHFLILLGLPLGGFFFGGLYTVFPLWLRPANLFFALIWSFFAYFYLIYGQILPSRWPKAKLNLVMVTMTGLSLLATVFNLFISSSPLEKYGTGSMTALTFLLGCCLLVLSKKSR","328001","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu0315 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[49-69]?$ $\"[84-104]?$ $\"[110-130]?$	transmembrane_regions

InterPro
IPR004881
Family

GTPase EngC
PF03193	$\"[2-274]T$	DUF258
TIGR00157	$\"[37-275]T$	TIGR00157: ribosome small subunit-dependent

InterPro
IPR010914
Domain

EngC GTPase
PS50936	$\"[71-211]T$	ENGC_GTPASE

noIPR
unintegrated

unintegrated
G3DSA:1.10.40.50	$\"[216-283]T$	no description
G3DSA:2.40.50.190	$\"[1-60]T$	no description
G3DSA:3.40.50.300	$\"[61-215]T$	no description

","BeTs to 8 clades of COG1162COG name: Predicted GTPasesFunctional Class: RThe phylogenetic pattern of COG1162 is -----Qvcebrh--gpo----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 129-181 are 54% similar to a (COMPLETE PROTEOME ATP-BINDING MG110) protein domain (PD222731) which is seen in Q9CEB7_LACLA.Residues 180-273 are 33% similar to a (ATP-BINDING MG110) protein domain (PD414441) which is seen in Q9KX59_MYCGA.Residues 186-276 are 68% similar to a (COMPLETE PROTEOME ATP-BINDING NUCLEOTIDE) protein domain (PD005268) which is seen in Q9CEB7_LACLA.Residues 3-114 are 69% similar to a (COMPLETE PROTEOME ATP-BINDING MG110) protein domain (PD006187) which is seen in Q9CEB7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:46:55 2002","Tue Sep 19 14:24:07 2006","Tue Sep 19 14:24:07 2006","Tue Oct 8 08:46:55 2002","","Thu Jan 17 14:31:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0316 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 08:46:55 2002","","No significant hits to the NCBI PDB database.","SMU.351","","Residues 129 to 274 (E-value = 5.8e-47) place SMu0316 in the DUF258 family which is described as Protein of unknown function, DUF258 (PF03193)","Thu Jan 17 14:31:06 2002","24378848","","","","","","1","","","SMU.351","475" "SMu0317","329429","330088","660","ATGTTGCTCAATCAAATTGCCCCTTCTATTTTAGCTGCAGATTATGCTAACTTTGAAAGTGAATTAAAGCGCATTGAAGAAACTGGTGTGAAGTACGTTCATATTGATATTATGGATGGACAGTTTGTTCCAAGCATTAGTTTTGGTGCCGGTGTTGTTGCTAGTATGCGTAAACATAGTAAGCTCGTCTTTGATTGTCATCTTATGGTAGTTAATCCAGAGCGTTATGTTGATGATTTTTCTCAAGCTGGTGCTGATATTATGACAGTACACGTAGAAGCCACCCATCATATTCACGGTGCCCTTCAAAAAATCAAGGATGCTGGTATGAAGGCAGGTATTGTCATCAATCCTGGAACACCAGTTGCTGATTTAGAATCTGTCTTGTCTTTAGCAGATCAGATACTTATTATGACAGTTAATCCCGGTTTTGGCGGTCAGGCTTTTATTCCAGAAATGTTGGAAAAAGTAAGAACTGTTGCTAAGCTTCGTGAAGAAAAGGGTTTATCATTTGATATTGAAGTTGATGGCGGTATTGACAATGAAACCATTAAGTTAGCAAAGCAAGCCGGCGCCAATATCTTTGTAGCAGGTTCTTACCTTTTCAAAGAAAATCTAGCTGCTCAAGTTGAAACTTTGAAAGCGGCTTTAAATGACTAA","5.00","-8.36","23708","MLLNQIAPSILAADYANFESELKRIEETGVKYVHIDIMDGQFVPSISFGAGVVASMRKHSKLVFDCHLMVVNPERYVDDFSQAGADIMTVHVEATHHIHGALQKIKDAGMKAGIVINPGTPVADLESVLSLADQILIMTVNPGFGGQAFIPEMLEKVRTVAKLREEKGLSFDIEVDGGIDNETIKLAKQAGANIFVAGSYLFKENLAAQVETLKAALND","330085","","ribulose-phosphate-3-epimerase","Cytoplasm","Several matches in gapped BLAST to ribulose-phosphate-3-epimerasesequences. Residues 5-218 are 78% similar to the enzyme from S.pyogenes (gi15674444) and 66% similar to the enzyme from S.pneumoniae (gi15903839).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1776 (4e-95).","

InterPro
IPR000056
Family

Ribulose-phosphate 3-epimerase
PTHR11749	$\"[16-205]T$	Ribul_P_3_epim
PF00834	$\"[5-205]T$	Ribul_P_3_epim
TIGR01163	$\"[5-214]T$	rpe
PS01086	$\"[135-157]T$	RIBUL_P_3_EPIMER_2

InterPro
IPR011060
Domain

Ribulose-phosphate binding barrel
SSF51366	$\"[2-219]T$	RibP_bind_barrel

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[6-214]T$	Aldolase_TIM

","BeTs to 12 clades of COG0036COG name: Pentose-5-phosphate-3-epimeraseFunctional Class: GThe phylogenetic pattern of COG0036 is -m--yqvcEbrhujgp-lin-Number of proteins in this genome belonging to this COG is 1","***** IPB000056 (Ribulose-phosphate 3-epimerase) with a combined E-value of 1.8e-84. IPB000056A 6-38 IPB000056B 63-91 IPB000056C 105-157 IPB000056D 173-202","Residues 6-70 are 55% similar to a (3-EPIMERASE RIBULOSE-PHOSPHATE ISOMERASE) protein domain (PD003683) which is seen in Q9CEB9_LACLA.Residues 73-145 are 57% similar to a (3-EPIMERASE RIBULOSE-PHOSPHATE ISOMERASE) protein domain (PD328129) which is seen in Q9K9Z2_BACHD.Residues 70-205 are 29% similar to a (CARBOHYDRATE ISOMERASE 5.1.3.- SGCE) protein domain (PD094873) which is seen in SGCE_ECOLI.Residues 72-145 are 42% similar to a (D-RIBULOSE-5-PHOSPHATE L9280.9) protein domain (PD406967) which is seen in Q9C8T3_ARATH.Residues 80-214 are 65% similar to a (DECARBOXYLASE LYASE SYNTHASE PYRIMIDINE BIOSYNTHESIS) protein domain (PD001042) which is seen in Q9CEB9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 14:39:06 2002","Thu Jan 17 14:31:58 2002","Thu Aug 31 17:09:28 2006","Thu Aug 31 17:09:28 2006","Thu Jan 17 14:31:58 2002","Thu Jan 17 14:31:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0317 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 17 14:39:06 2002","Thu Aug 31 17:09:28 2006","pdb1RPXA Chain A, D-Ribulose-5-Phosphate 3-Epimerase From Sol... 192 4e-050","SMU.352","","Residues 5 to 205 (E-value = 2.8e-103) place SMu0317 in the Ribul_P_3_epim family which is described as Ribulose-phosphate 3 epimerase family (PF00834)","Thu Jan 17 14:31:58 2002","24378849","","","","","","1","","","SMU.352","604" "SMu0318","330081","330713","633","ATGACTAAGGTAGCTCTGTTTTCTGGAGGCGATCTTACTTATTTCACGAGAGATTTTGACTATTTTGTAGGTATTGATAAGGGAAGTTCTTTTCTGTTGAAAAATCAGTTACCGTTAGACTTAGCTATTGGGGATTTTGATTCTGTCTCAGCAGAGGAATTTAAGCAGATTAAAGCCAAGGCTAAAAAGCTGGTGATGGCTCCTGCAGAAAAAAATGATACAGATACAGAGTTGGCTTTAAAAACAATTTTTGACTGTTTTGGCAGGGTTGAAATAATTGTTTTTGGTGCTTTTGGCGGTCGGATAGACCATATGCTGTCCAATATTTTTTTACCTAGCGATCCTGATTTAGCTCCTTTTATGCGCTGTTTTAAATTACGTGATGAACAAAATTTAGTGGAATTTTTTCCAGCAGGGCAACATCAAATTGAACAGGCAACTGATATGGTTTATATTTCCTTTATGGCAGCAAACGGCGCTCATCTGTCTATTCAAGATGCTAAATACGAATTAACAGAAGAGAACTACTTTCAAAAGAAAATTTACAGCAGCAATGAATTTAAGGACAAACCGATTTGTTTTTCAGTCGCTTCAGGTTATGTTGTTGTCATTCAAACAAAAGATAGGACCTAA","4.90","-6.42","23699","MTKVALFSGGDLTYFTRDFDYFVGIDKGSSFLLKNQLPLDLAIGDFDSVSAEEFKQIKAKAKKLVMAPAEKNDTDTELALKTIFDCFGRVEIIVFGAFGGRIDHMLSNIFLPSDPDLAPFMRCFKLRDEQNLVEFFPAGQHQIEQATDMVYISFMAANGAHLSIQDAKYELTEENYFQKKIYSSNEFKDKPICFSVASGYVVVIQTKDRT","330710","","thiamine pyrophosphokinase","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-208 are 61% similar to gi15674445 from S.pyogenes. Residues 2-209 are 50% similar to gi15903838 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1775 (8e-71).","

InterPro
IPR006282
Family

Thiamine pyrophosphokinase
TIGR01378	$\"[4-204]T$	thi_PPkinase

InterPro
IPR007371
Domain

Thiamin pyrophosphokinase, catalytic region
PF04263	$\"[9-129]T$	TPK_catalytic

InterPro
IPR007373
Domain

Thiamin pyrophosphokinase, vitamin B1-binding region
PF04265	$\"[139-203]T$	TPK_B1_binding

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10240	$\"[4-111]T$	G3DSA:3.40.50.10240
PTHR13622	$\"[10-207]T$	PTHR13622
SSF63862	$\"[130-208]T$	SSF63862
SSF63999	$\"[1-128]T$	SSF63999

","BeTs to 4 clades of COG1564COG name: Predicted nucleotide-binding proteinFunctional Class: RThe phylogenetic pattern of COG1564 is ------v--b--uj---l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 19-171 are 40% similar to a (PROTEOME COMPLETE YSJC YLOS) protein domain (PD111869) which is seen in Q9CEL3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Aug 18 16:34:52 2006","Fri Aug 18 16:34:52 2006","Fri Aug 18 16:34:52 2006","Fri Aug 18 16:34:52 2006","","Thu Jan 17 14:41:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0318 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Aug 18 16:34:52 2006","","No significant hits to the NCBI PDB database.","SMU.353","","Residues 9 to 129 (E-value = 1.9e-34) place SMu0318 in the TPK_catalytic family which is described as Thiamin pyrophosphokinase, catalytic domain (PF04263)Residues 139 to 203 (E-value = 2.3e-14) place SMu0318 in the TPK_B1_binding family which is described as Thiamin pyrophosphokinase, vitamin B1 binding domain (PF04265)","Fri Aug 18 16:34:52 2006","24378850","","","","","","1","","","SMU.353","728" "SMu0319","330720","331994","1275","ATGGATATTCTTACTCTCTTACTGGCTTTGACAGCTTGTTTTATCAGCTCTGCTATTTTTCTAAAACTGGATAAAAATCAATCGGGACTTGAAAAAAAGTTAGATGACAATGCGGATAACCTTTCTGATCAAGTTTCTTATCAGTTGGAGGTTGCTAATAAAAATCAATTGCTTGCAATTAATCAGCAGTTGACACGTTTACAAAATGATCTCTCTCAACAATTAACTGACTTAAGAGAGGTATTACATCAAAATCTAAATGACAGTCGGGATCGATCGGATAAGCGTTTAGAGCAAATCAATTTACAATTAAATCAGTCGGTCAAAGAAATGCAAACTTCCAATGAAAAACGCTTGGAAGAGATGCGGCAAACCGTTGCAGAAAAATTAGACCAAACCTTACATACGCGCCTGAAAACATCTTTCGAAACTGTTTCTAAGCAGTTGGAAAATGTTAATCAAGGTTTGGGTGAAATGAAGAACATGGCACGTGATGTTGGTACCTTGAATAAGGTTCTGTCCAATACTAAAACACGGGGAATTCTGGGTGAATTACAATTAAGCCAAATTATTGAAGATATTATGACCGAATCTCAATATGAACGTGAATTTGCAACTGTGAAGGACTCAAAAGAACGTGTGGAATATGCTATTAAATTGCCGGGGAATCAGCAAGGAACCTATGTTTACCTACCTATTGATTCTAAGTTTCCACTGGAAAATTATTATCGTTTGGAAGATGCCTATGATCTTGGTAATAAGGAGCAAATTGATCTTTATCGAAAAAAACTGCTAAGCAGTATCAAGACTTTTGCTAAAGATATTCAAAAGAAATATCTCAATCCACCAGAAACAACCAATTTTGGGATTATGTTTTTGCCAACAGAAGGGCTTTATTCGGAAGTTGTTAGAAATGCAAGTTTCTTTGATGCTTTGCGGCGTGATGAACATATTGTTGTAGCGGGTCCGTCAACTTTATCAGCTCTCTTAAATTCTTTGTCTGTTGGTTTTAAAACATTGAATATTCAAAAAAATGCTGATGATATCAGTAAAATTTTAGGAAATGTCAAGACAGAATTTGCTAAGTTTGGAGGTCTTTTACAGACAACCAAAAAACAACTCAATCAAGCTAGCAACAATATTGATAAACTTTTAACAACACGCACCAATGCAATTGGTCGAGCACTAAGAAACATTGAATTATATGAGGATGAAAGCACTAAGTCGGCTTTAAACCTTCCGCCGCTAGAAGATGAGGAATCAAATGAAAATTAA","5.30","-6.28","48241","MDILTLLLALTACFISSAIFLKLDKNQSGLEKKLDDNADNLSDQVSYQLEVANKNQLLAINQQLTRLQNDLSQQLTDLREVLHQNLNDSRDRSDKRLEQINLQLNQSVKEMQTSNEKRLEEMRQTVAEKLDQTLHTRLKTSFETVSKQLENVNQGLGEMKNMARDVGTLNKVLSNTKTRGILGELQLSQIIEDIMTESQYEREFATVKDSKERVEYAIKLPGNQQGTYVYLPIDSKFPLENYYRLEDAYDLGNKEQIDLYRKKLLSSIKTFAKDIQKKYLNPPETTNFGIMFLPTEGLYSEVVRNASFFDALRRDEHIVVAGPSTLSALLNSLSVGFKTLNIQKNADDISKILGNVKTEFAKFGGLLQTTKKQLNQASNNIDKLLTTRTNAIGRALRNIELYEDESTKSALNLPPLEDEESNEN","331991","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-424 are 70% similar to gi|15674446| from S.pyogenes. Residues 3-419 are 58% similar to gi|15903837 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1774 (1e-171).","

InterPro
IPR003798
Domain

RmuC
PF02646	$\"[116-416]T$	RmuC

noIPR
unintegrated

unintegrated
PD013253	$\"[6-154]T$	PD013253
SSF47162	$\"[23-155]T$	SSF47162

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 177-377 are 47% similar to a (COMPLETE PROTEOME UDP-UBIE PERIPLASMIC) protein domain (PD041459) which is seen in Q9CEC0_LACLA.Residues 23-174 are 35% similar to a (PROTEOME COMPLETE XF0413 YUAB) protein domain (PD317459) which is seen in Q9CEC0_LACLA.Residues 29-213 are 25% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in P70615_RAT.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 14:45:37 2002","Thu Jan 17 14:44:42 2002","Thu Jan 17 14:45:37 2002","Thu Jan 17 14:44:42 2002","","Thu Jan 17 14:44:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0319 is paralogously related (blast p-value < 1e-3) to SMu1375, a predicted chromosome segregation ATPase.","Thu Jan 17 14:45:37 2002","","No significant hits to the NCBI PDB database.","SMU.354","","Residues 116 to 416 (E-value = 1.4e-133) place SMu0319 in the RmuC family which is described as RmuC family (PF02646)","Thu Jan 17 14:44:42 2002","24378851","","","","","","1","","","SMU.354","474" "SMu0320","331984","332952","969","ATGAAAATTAATCAAATGAAAAAAGATGAACTTTTCGAGGGATTTTATCTCATTAAATCAGCAGAGCTCAGAAAAACAAGAGCAGGAAAAGATTACCTTGCCTTTACCTTTCAAGATGATAGTGGAGAAATTTCTGGTAATCTTTGGGATGCTCAGCCTTATAATGTTGAAGAATTTACTGCTGGGAAAGTTGTCTTTATGAGGGGACGCCGTGAAGTTTATAATGGGACACCACAAGTCAATCAAATCAGCTTACGGCATCCTAAGGATGGAGAGCCTAATGATCCTAGAGATTTTAAAGAAAAACCGCCTGTTGATGTTGAAGAGGTCAAAGATTATCTTGAACAGATGCTCTTCAAAATCGAAAATGCTACCTGGCAGCGGATTGTCCGTGCCCTTTATCGTAAGTATAGTAAAGAATTTTTCAGCTTTCCGGCAGCTAAAACAAATCACCATGCTTTTGAAGTTGGTCTGGCCTATCATACAGCAACTATGGTTCGTTTGGCTGATAGTATCGGGGATATTTATGAAGAACTTGACAAAAGTCTTCTGTTTGCGGGTATCATGCTGCATGATTTAGCCAAAGTTCTTGAGCTATCTGGTCCTGATAATACCGAATATACTATTCGTGGCAATCTTATTGGTCATATTGCTTTGATCGATGAAGAAATTACTAAAGTTTTATCAGAATTGTCTATTGATGATACTAAGGAAGATGTTATTGTCTTGCGCCATGTTATTCTCAGCCATCATGGTCTCTTAGAATATGGCAGTCCCGTTAGACCTAAAATTATGGAAGCAGAAATCATTCATATGATTGATAATATTGATGCTGAAATGATGATGATGACGACTGCTCTATCTCGTGTATCAGAAGGAGAGATGACTGGTCGTATCTTTGCTATGGATAATCGTTCTTTCTATAAACCTAAAACAAACCATCAAAACACGAAAAAAGATGACTATTAG","5.50","-9.32","37081","MKINQMKKDELFEGFYLIKSAELRKTRAGKDYLAFTFQDDSGEISGNLWDAQPYNVEEFTAGKVVFMRGRREVYNGTPQVNQISLRHPKDGEPNDPRDFKEKPPVDVEEVKDYLEQMLFKIENATWQRIVRALYRKYSKEFFSFPAAKTNHHAFEVGLAYHTATMVRLADSIGDIYEELDKSLLFAGIMLHDLAKVLELSGPDNTEYTIRGNLIGHIALIDEEITKVLSELSIDDTKEDVIVLRHVILSHHGLLEYGSPVRPKIMEAEIIHMIDNIDAEMMMMTTALSRVSEGEMTGRIFAMDNRSFYKPKTNHQNTKKDDY","332949","","CMP-binding factor 1","Cytoplasm","Matches in gapped BLAST to CMP-binding factors. Residues 1-310 are 87% similar to gi15674447, the predicted factor from S.pyogenes and 78% similar to the protein from S.pneumoniae (gi15903836).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1773 (1e-161).","

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[154-288]T$	HDc

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[16-86]T$	tRNA_anti

InterPro
IPR006674
Domain

Metal-dependent phosphohydrolase, HD region, subdomain
PF01966	$\"[158-279]T$	HD

noIPR
unintegrated

unintegrated
SSF52141	$\"[111-183]T$	UDNA_glycsylseSF

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 144-280 are 63% similar to a (COMPLETE PROTEOME CMP-BINDING) protein domain (PD017443) which is seen in Q9CEC1_LACLA.Residues 10-105 are 62% similar to a (PROTEOME COMPLETE CMP-BINDING) protein domain (PD038968) which is seen in Q9CEC1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 12:11:52 2002","Thu Jan 17 14:49:39 2002","Tue Sep 19 13:51:53 2006","Thu Jan 17 14:49:39 2002","","Thu Jan 17 14:49:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0320 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 10 12:11:52 2002","","No significant hits to the NCBI PDB database.","SMU.355","","Residues 158 to 279 (E-value = 4.7e-05) place SMu0320 in the HD family which is described as HD domain (PF01966)","Thu Jan 17 14:49:39 2002","24378852","","","","","","1","","","SMU.355","473" "SMu0321","333020","333835","816","ATGAAATTGCGACGTAGCGAACGAATGGTTGTTATTTCAAATTATTTAATTAACAACCCCTATCAACTAACCAGTCTTAATACTTTTGCTCAAAAGTATGAAGCGGCAAAGTCTTCGATTTCTGAAGATATTGCAATTATTAAGAAAGCTTTTGCTCACGCTGATATTGGCCATATTAAGACGATAACTGGTGCCAATGGTGGTGTTGTTTTTACACCGACTATTTCAAATGATGAAGCGAGAACGGTTGCACAAGAACTTTGTCAGCGGCTGGCAGAAAGCAACCGTATCTTGCCGGGTGGCTATATTTATTTGTCTGATTTACTATCGACACCAAGTATTCTAAAAAATATCGGTCGTATTATTGCCAATGCTTTTAAAGATGAAAAAATTGATGCTGTTATGACAGTGGCAACCAAAGGTGTTCCTTTGGCTAATGCCGTTGCTAATATTCTTAATGTCCCTTTTGTCATTGTGCGTCGAGATTTGAAGATTACAGAAGGTTCAACAGTATCTGTTAATTATGCTTCTGGATCAAGCGATCGTATTGAAAAGATGTTTTTATCAAAACGCAGTTTAAATCCCAACAGTTGCGTTTTAATTGTTGATGATTTTCTTAAGGGTGGGGGAACCATCAGTGGTATGGTTAGCCTTTTGAGCGAATTTGACAGTCAGTTGGTTGGAGTGGCTGTCTTTGCCGATAATGCTCAGGAAAAACGTGAGGGCATCAGCTATAAATCTCTTTTAACAGTAACCAATATTGATGTTAAAGAAAGCAAGGTAGATGTTAAGTTGGGAAATATTTTTAGTAAATGA","9.80","5.39","29423","MKLRRSERMVVISNYLINNPYQLTSLNTFAQKYEAAKSSISEDIAIIKKAFAHADIGHIKTITGANGGVVFTPTISNDEARTVAQELCQRLAESNRILPGGYIYLSDLLSTPSILKNIGRIIANAFKDEKIDAVMTVATKGVPLANAVANILNVPFVIVRRDLKITEGSTVSVNYASGSSDRIEKMFLSKRSLNPNSCVLIVDDFLKGGGTISGMVSLLSEFDSQLVGVAVFADNAQEKREGISYKSLLTVTNIDVKESKVDVKLGNIFSK","333832","For other 'pur' genes see SMu0025 (pur7); SMu0026 (purL); SMu0028 (purF),(purB) ; SMu0030 (purM); SMu0031 (purN); SMu0033 (purH); SMu0044 (purD); SMu0046 (purE); SMu0047 (purK); SMu0054 (purB); SMu0243 (purA).","purine operon repressor/xanthine phosphoribosyltransferase","Cytoplasm, Membrane","Matches in gapped BLAST to purR sequences. Residues 1-271 are 82% similar to gi15674448 from S.pyogenes and 77% similar to gi15901802 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1772 (1e-119).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[104-243]T$	Pribosyltran

InterPro
IPR010078
Family

Pur operon repressor
TIGR01743	$\"[3-269]T$	purR_Bsub

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-73]T$	Wing_hlx_DNA_bd

InterPro
IPR015265
Domain

Bacterial purine repressor, N-terminal
PF09182	$\"[4-73]T$	PuR_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2020	$\"[74-270]T$	G3DSA:3.40.50.2020
SSF46785	$\"[2-74]T$	SSF46785
SSF53271	$\"[78-248]T$	SSF53271

","BeTs to 12 clades of COG0503COG name: Adenine/guanine phosphoribosyltransferasesFunctional Class: FThe phylogenetic pattern of COG0503 is -mtkY-vcEBrHujgpol---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 14:57:56 2007","Thu Feb 8 12:05:31 2007","Thu Feb 8 12:05:31 2007","Thu Mar 28 13:32:48 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0321 is paralogously related (blast p-value < 1e-3) to SMu1336, a predicted adenine phosphoribosyltransferase.","Thu Jan 17 14:59:43 2002","","No significant hits to the NCBI PDB database.","SMU.356","","Residues 104 to 243 (E-value = 5.4e-17) place SMu0321 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Thu Jan 17 14:54:42 2002","24378853","","","Weng,M., Nagy,P.L. and Zalkin,H.Identification of the Bacillus subtilis pur operon repressorProc. Natl. Acad. Sci. U.S.A. 92 (16), 7455-7459 (1995)PubMed: 7638212","","Thu Mar 28 13:32:48 2002","1","","","SMU.356","472" "SMu0322","334095","334508","414","ATGCCTACAATTAACCAGTTGGTTCGTAAGCCACGTAAGTCTAAAGTAGAAAAATCTGACTCACCAGCATTGAATATTGGCTATAATAGCCATAAAAAAGTTCATACTAAACTTGCTGCACCTCAAAAACGCGGTGTTGCAACACGTGTTGGAACAATGACCCCTAAGAAACCTAACTCTGCTCTTCGTAAATTTGCTCGTGTTCGTTTGAGTAACCTTATTGAAGTCACTGCTTATATTCCAGGTATTGGTCACAATCTGCAAGAACACAGTGTTGTACTTATTCGTGGTGGACGTGTAAAGGACCTTCCAGGGGTACGTTACCATATTGTTCGTGGTGCACTTGATACTGCCGGTGTTACTGATCGTAAACAAGGCCGTTCTAAATATGGTACTAAGAAACCAAAAGCATAA","11.90","24.18","15092","MPTINQLVRKPRKSKVEKSDSPALNIGYNSHKKVHTKLAAPQKRGVATRVGTMTPKKPNSALRKFARVRLSNLIEVTAYIPGIGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDTAGVTDRKQGRSKYGTKKPKA","334505","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1841 (rps10);SMu1838 (rps19); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).","30S ribosomal protein S12","Periplasm, Membrane, Cytoplasm","Matches in gapped BLAST to 30S ribosomal protein S12 sequences. Residues 1-136 are 95% similar to gi|15674450 from S.pyogenes. Residues 1-137 are 92% similar to gi|15900205 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1771 (3e-73).","

InterPro
IPR005679
Family

Ribosomal protein S12, bacterial and chloroplast form
PR01034	$\"[40-55]T$ $\"[55-70]T$ $\"[71-90]T$ $\"[90-107]T$ $\"[107-123]T$ $\"[123-135]T$	RIBOSOMALS12
PTHR11652:SF1	$\"[1-136]T$	Ribosom_S12_bac
TIGR00981	$\"[1-137]T$	rpsL_bact

InterPro
IPR006032
Family

Ribosomal protein S12/S23
PTHR11652	$\"[1-136]T$	Ribosomal_S12_23
PF00164	$\"[2-136]T$	Ribosomal_S12
PS00055	$\"[56-63]T$	RIBOSOMAL_S12

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[1-136]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
SSF50249	$\"[2-136]T$	Nucleic_acid_OB

","BeTs to 17 clades of COG0048COG name: Ribosomal protein S12Functional Class: JThe phylogenetic pattern of COG0048 is amtkYQvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000230 (Ribosomal protein S12) with a combined E-value of 2e-33. IPB000230 78-113","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 12:14:51 2002","Thu Jan 17 15:00:19 2002","Thu Jan 17 15:05:11 2002","Thu Apr 4 14:53:55 2002","Thu Jan 17 15:00:19 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0322 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 17 15:05:11 2002","Thu Jan 17 15:00:19 2002","pdb|1FJF|L Chain L, Structure Of The Thermus Thermophilus 30s R... 175 3e-045pdb|1FJF|L Chain L, Structure Of The Thermus Thermophilus 30s R... 224 4e-060","SMU.357","","Residues 3 to 136 (E-value = 8.9e-70) place SMu0322 in the Ribosomal_S12 family which is described as Ribosomal protein S12 (PF00164)","Thu Jan 17 15:00:19 2002","24378854","","","Salles,C., Creancier,L., Claverys,J.P. and Mejean,V.The high level streptomycin resistance gene from Streptococcuspneumoniae is a homologue of the ribosomal protein S12 gene fromEscherichia coliNucleic Acids Res. 20 (22), 6103 (1992)PubMed: 1461744","","Thu Apr 4 14:53:55 2002","1","","","SMU.357","727" "SMu0323","334526","334996","471","ATGAGTCGTAAAAACCGTGCGCCTAAGCGCGAAGTATTGCCAGATCCATTATACAATTCAAAACTTGTAACACGTCTTATCAACCGTATTATGCTTGATGGTAAACGTGGTACAGCTGCATCTATCGTTTATGGAGCTTTTGAACAAATTAAGGAAGCAACAGGGAATGATGCACTTGAAGTCTTTGAACAAGCCATGGAAAATATCATGCCTGTACTTGAAGTACGTGCACGTCGTGTTGGTGGTTCTAACTATCAAGTCCCAGTTGAAGTTCGTCCTGAACGTCGTACAACATTAGGTCTTCGTTGGTTGGTGACTGCATCACGTACTCGTGGTGAACACACAATGAAAGATCGTCTTGCAAAAGAAATCTTAGATGCGTCAAATAATACAGGTGCCTCAGTTAAAAAACGTGAAGATACACATCGTATGGCTGAAGCTAACCGTGCTTTTGCACACTTCCGTTGGTAG","11.20","10.72","17790","MSRKNRAPKREVLPDPLYNSKLVTRLINRIMLDGKRGTAASIVYGAFEQIKEATGNDALEVFEQAMENIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLRWLVTASRTRGEHTMKDRLAKEILDASNNTGASVKKREDTHRMAEANRAFAHFRW","334993","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1841 (rps10);SMu1838 (rps19); SMu0322 (rpsL); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).","30S ribosomal protein S7","Cytoplasm","Matches in gapped BLAST to 30S ribosomal protein S7 sequences. Residues 1-156 are 92% similar to gi|15900206 from S.pneumoniae and 91% similar to gi|15674451 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1770 (2e-80).","

InterPro
IPR000235
Family

Ribosomal protein S7
PD000817	$\"[19-142]T$	Ribosomal_S7
G3DSA:1.10.455.10	$\"[6-156]T$	Ribosomal_S7
PIRSF002122	$\"[15-156]T$	Ribosomal_S7
PTHR11205	$\"[1-156]T$	Ribosomal_S7
PF00177	$\"[1-149]T$	Ribosomal_S7
PS00052	$\"[20-46]T$	RIBOSOMAL_S7
SSF47973	$\"[1-149]T$	Ribosomal_S7

InterPro
IPR005717
Family

Ribosomal protein S7, bacterial and organelle form
TIGR01029	$\"[3-156]T$	rpsG_bact

","BeTs to 17 clades of COG0049COG name: Ribosomal protein S7Functional Class: JThe phylogenetic pattern of COG0049 is amtkYQvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000235 (Ribosomal protein S7) with a combined E-value of 1.3e-51. IPB000235A 53-104 IPB000235B 123-149","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 12:15:16 2002","Thu Jan 17 15:07:06 2002","Thu Jan 17 15:12:28 2002","Thu Apr 4 14:54:41 2002","Thu Jan 17 15:07:06 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0323 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 17 15:12:28 2002","Thu Jan 17 15:07:06 2002","pdb|1HUS| Ribosomal Protein S7 222 1e-059pdb|1FJF|G Chain G, Structure Of The Thermus Thermophilus 30s R... 174 5e-045pdb|1RSS| Ribosomal Protein S7 From Thermus Thermophilus 167 6e-043","SMU.358","","Residues 1 to 149 (E-value = 1.4e-83) place SMu0323 in the Ribosomal_S7 family which is described as Ribosomal protein S7p/S5e (PF00177)","Thu Jan 17 15:07:06 2002","24378855","","","Higo,K., Otaka,E. and Osawa,S.Purification and characterization of 30S ribosomal proteins fromBacillus subtilis: correlation to Escherichia coli 30S proteinsMol. Gen. Genet. 185 (2), 239-244 (1982)PubMed: 6806564","","Thu Apr 4 14:54:41 2002","1","","","SMU.358","726" "SMu0324","335165","337246","2082","ATGGCTCGTGAATTTTCACTTGAAAAAACTCGTAATATCGGTATCATGGCTCACGTTGATGCTGGTAAAACAACTACAACAGAGCGTATTCTTTACTATACTGGTAAAATTCATAAGATTGGTGAAACACACGAAGGTGCTTCACAAATGGACTGGATGGAACAAGAGCAAGAACGTGGTATCACAATCACTTCAGCTGCAACGACTGCTCAATGGAAAGACCATCGTGTCAATATTATTGACACACCGGGGCACGTAGACTTTACTATCGAAGTGCAACGTTCCCTTCGTGTTCTAGATGGTGCTGTTACTGTTCTTGATGCTCAGTCAGGTGTTGAACCTCAAACAGAAACTGTTTGGCGTCAAGCAACTGAGTATGGTGTTCCTCGTATCGTATTTGCTAATAAGATGGATAAAATTGGTGCTGATTTCCTTTATTCAGTGAGCACTCTTCATGATCGTCTTCAAGCAAATGCACACCCTATTCAATTGCCGATCGGAGCAGAAGATGATTTTGAAGGTATTATTGATTTGGTAACAATGAAAGCCGAAATCTATACAAATGATCTTGGTACAGATATTTTGATTGAAGATATTCCTGCTGATTACCTTGATCAAGCTAAAGAATACCGTGAAAAATTGATTGAGGCAGTTGCTGAAACTGATGAAGATCTGATGATGAAATATCTTGAAGGTGAAGAAATCACTGAAACAGAATTAAAAGCAGCTATTCGTAAAGCTACTATTAATGTTGAATTCTTTCCAGTTCTTGCGGGTTCAGCTTTCAAGAATAAAGGCGTCCAAATGATGCTTGATGCGGTTGTTGATTACCTTCCAAGTCCGCTTGATATTCCTCCTATTAAAGGTGTTAATCCAGATACTGATGAAGAAGAAGAGCGCCCAGCATCTGATGATGAACCATTTGCTGCTCTTGCCTTTAAGATTATGACTGACCCATTCGTGGGACGTTTGACTTTCTTCCGTGTTTATTCTGGTATCCTAAACAGTGGTTCTTATGTGTTGAATACCTCTAAAGGAAAACGTGAACGTATTGGACGTATCCTTCAAATGCATGCCAACAGCCGTCAAGAAATTGAAACCGTTTATGCTGGTGATATTGCGGCTGCAGTTGGTTTGAAAGAAACAACAACTGGAGATTCATTAACTGATGAAAAAGCAAAAGTGATTCTTGAATCAATTGAAGTTCCAGAACCTGTTATTCAGTTGATGGTTGAGCCAAAATCGAAAGCCGATCAAGATAAAATGGGGATTGCTCTTCAAAAACTTGCTGAGGAAGATCCAACTTTCCGTGTGGAAACAAATGTTGAAACAGGTGAAACCGTTATTTCTGGTATGGGTGAGCTTCACTTGGATGTCCTTGTTGACCGTATGAAACGCGAATTCAAGGTTGAAGCTAATGTTGGTGCTCCTCAGGTGTCATATCGTGAAACTTTCCGTCAAGCTACGCAAGCACGTGGTTTCTTTAAACGCCAATCCGGTGGTAAAGGTCAATTTGGTGATGTTTGGATTGAATTTACTCCAAATGAAGAAGGTAAAGGGTTCGAGTTTGAAAATGCTATTGTGGGTGGTGTTGTTCCACGTGAATTTGTTCCGGCCGTAGAAAAAGGTTTGATTGAATCTATGGCTAATGGTGTTCTTGCTGGTTACCCAATTGTTGATGTTAAGGCCAAACTTTATGATGGTTCTTACCATGATGTTGACTCATCTGAAACAGCCTTCAAGATTGCTGCGTCGCTTGCTCTTAAGGAAGCTGCTAAAACTGCGAAACCTGTTATTCTTGAACCAATGATGTTAGTCACTATCACTGTTCCTGAAGAAAACCTTGGTGATGTTATGGGGCATGTCACTGCCCGTCGTGGACGTGTTGATGGCATGGAAGCACATGGTAATAGTCAAATTGTTCGTGCTTTTGTTCCGCTTGCTGAAATGTTCGGTTATGCAACTGTTCTTCGTTCAGCATCTCAAGGACGTGGGACCTTTATGATGGTATTTGACCACTATGAAGATGTTCCAAAATCTGTTCAAGAAGAGATCATTAAGAAAAACGCTGGAGAAGCTTAA","4.60","-36.75","76658","MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWKDHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDAQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAHPIQLPIGAEDDFEGIIDLVTMKAEIYTNDLGTDILIEDIPADYLDQAKEYREKLIEAVAETDEDLMMKYLEGEEITETELKAAIRKATINVEFFPVLAGSAFKNKGVQMMLDAVVDYLPSPLDIPPIKGVNPDTDEEEERPASDDEPFAALAFKIMTDPFVGRLTFFRVYSGILNSGSYVLNTSKGKRERIGRILQMHANSRQEIETVYAGDIAAAVGLKETTTGDSLTDEKAKVILESIEVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMKREFKVEANVGAPQVSYRETFRQATQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFVPAVEKGLIESMANGVLAGYPIVDVKAKLYDGSYHDVDSSETAFKIAASLALKEAAKTAKPVILEPMMLVTITVPEENLGDVMGHVTARRGRVDGMEAHGNSQIVRAFVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQEEIIKKNAGEA","337243","","translation elongation factor G/EF-2","Cytoplasm","This sequence most closely corresponds to gi135623, gi80004, gi153117, and a fragment, gi280249, in GenBank. Residues 9-675 are 25% similar to TETO_STRMU. Residues 323-471 are 28% similar to residues 7-154 of gi280249, a predicted EF-G homolog.Residues 1-692 are 94% similar to gi15900207, a predicted EF-Gprotein from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1769 (0.0).","

InterPro
IPR000640
Domain

Translation elongation factor EFG/EF2, C-terminal
G3DSA:3.30.70.240	$\"[601-689]T$	Transl_elong_EFG/EF2_C
PF00679	$\"[598-685]T$	EFG_C

InterPro
IPR000795
Domain

Protein synthesis factor, GTP-binding
PR00315	$\"[12-25]T$ $\"[58-66]T$ $\"[78-88]T$ $\"[94-105]T$ $\"[130-139]T$	ELONGATNFCT
PF00009	$\"[8-282]T$	GTP_EFTU
PS00301	$\"[51-66]T$	EFACTOR_GTP

InterPro
IPR004161
Domain

Translation elongation factor EFTu/EF1A, domain 2
PF03144	$\"[322-389]T$	GTP_EFTU_D2

InterPro
IPR004540
Family

Translation elongation factor EFG/EF2
TIGR00484	$\"[1-691]T$	EF-G

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[8-181]T$	small_GTP

InterPro
IPR005517
Domain

Translation elongation factor EFG/EF2, domain IV
PF03764	$\"[477-596]T$	EFG_IV

InterPro
IPR009000
Domain

Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447	$\"[264-399]T$	Translat_factor

InterPro
IPR009022
Domain

Elongation factor G, III and V
SSF54980	$\"[400-478]T$ $\"[598-687]T$	EFG_III_V

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[482-600]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
G3DSA:2.40.30.10	$\"[302-399]T$	G3DSA:2.40.30.10
G3DSA:3.30.70.870	$\"[401-479]T$	G3DSA:3.30.70.870
G3DSA:3.40.50.300	$\"[7-284]T$	G3DSA:3.40.50.300
PTHR23115	$\"[1-157]T$ $\"[240-281]T$ $\"[301-422]T$	PTHR23115
PTHR23115:SF13	$\"[1-157]T$ $\"[240-281]T$ $\"[301-422]T$	PTHR23115:SF13
SSF52540	$\"[1-280]T$	SSF52540
SSF54211	$\"[474-597]T$	SSF54211

InterPro
IPR000173
Family

Glyceraldehyde 3-phosphate dehydrogenase
PR00078	$\"[111-124]T$ $\"[147-165]T$ $\"[174-190]T$ $\"[232-249]T$ $\"[268-283]T$	G3PDHDRGNASE
PTHR10836	$\"[3-335]T$	GAP_DH
PF00044	$\"[3-153]T$	Gp_dh_N
PF02800	$\"[158-315]T$	Gp_dh_C
PS00071	$\"[151-158]T$	GAPDH

InterPro
IPR006424
Family

Glyceraldehyde-3-phosphate dehydrogenase, type I
TIGR01534	$\"[4-327]T$	GAPDH-I

noIPR
unintegrated

unintegrated
G3DSA:3.30.360.10	$\"[152-317]T$	G3DSA:3.30.360.10
SSF51735	$\"[3-170]T$	SSF51735
SSF55347	$\"[153-316]T$	SSF55347

","BeTs to 15 clades of COG0057COG name: Glyceraldehyde-3-phosphate dehydrogenaseFunctional Class: GThe phylogenetic pattern of COG0057 is amtkYqvCEBrhUJgpolin-Number of proteins in this genome belonging to this COG is 1","***** IPB000173 (Glyceraldehyde 3-phosphate dehydrogenase) with a combined E-value of 3e-113. IPB000173A 4-15 IPB000173B 89-125 IPB000173C 147-181 IPB000173D 186-239 IPB000173E 249-302 IPB000173F 308-328 IPB000173B 91-127 IPB000173B 90-126","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 13:33:32 2006","Thu Jan 17 15:44:56 2002","Tue Sep 19 13:32:23 2006","Thu Apr 4 11:41:20 2002","Thu Jan 17 15:38:09 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0325 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 17 15:44:56 2002","Tue Sep 19 13:32:23 2006","pdb1GD1O Chain O, holo-D-Glyceraldehyde-3-Phosphate Dehydroge... 344 9e-096pdb1HDGO Chain O, Holo-D-Glyceraldehyde-3-Phosphate Dehydroge... 342 3e-095pdb2DBVO Chain O, Glyceraldehyde-3-Phosphate Dehydrogenase Mu... 340 2e-094","SMU.360","","Residues 3 to 153 (E-value = 8.5e-84) place SMu0325 in the Gp_dh_N family which is described as Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (PF00044)Residues 154 to 315 (E-value = 1.9e-106) place SMu0325 in the Gp_dh_C family which is described as Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (PF02800)","Tue Sep 19 13:32:23 2006","24378857","","Pancholi,V. and Fischetti,V.A.A major surface protein on group A streptococci is aglyceraldehyde-3-phosphate-dehydrogenase with multiple bindingactivityJ. Exp. Med. 176 (2), 415-426 (1992)PubMed: 1500854Lottenberg,R., Broder,C.C., Boyle,M.D., Kain,S.J., Schroeder,B.L.and Curtiss,R. III.Cloning, sequence analysis, and expression in Escherichia coli of a streptococcal plasmin receptorJ. Bacteriol. 174 (16), 5204-5210 (1992)PubMed: 1322883","","Thu Apr 4 11:41:45 2002","","1","","","SMU.360","471" "SMu0326","338960","340156","1197","ATGGCAAAATTGACTGTTAAAGATGTTGATTTGAAAGGGAAGAAAGTTCTCGTTCGTGTTGACTTTAATGTCCCTGTAAAAGATGGCGTTATTACAAATGATAACCGTATTACTGCAGCTCTTCCAACAATTAAATACATCATTGAACATGGTGGTCGTGCTGTTCTTTTCTCTCACCTTGGACGTGTCAAAGAGGAAGCAGATAAAAAAGGGAAATCTCTTGCTCCTGTAGCTGCTGATTTGGCTAAAAAGCTTGTGCAAGAAGTTGTTTTTCCAGGTGTAACACGTGGTGAACAATTAGAAGCAGCTATTAATGCTCTTAAAAATGGTGAAGTTCTTTTGGTTGAAAACACTCGTTTTGAAGATGTTGATGGTAAAAAAGAATCTAAAAATGATCCTGAGCTTGGTAAATATTGGGCAAGTCTTGGCGATGGCATTTTTGTAAATGATGCATTTGGTACTGCTCACCGTGCTCACGCCTCTAATGTTGGTATTTCAGCTAATGTGGACAAAGCAGTTGCTGGCTTTCTTCTTGAAAACGAAATTGCTTACATTCAAGAAGCTGTTGACAATCCTGTTCGCCCATTTATCGCTATCCTTGGTGGTTCAAAAGTTTCAGATAAGATTGGTGTTATTGAAAATCTTCTTAAAAAAGCTGATAAAGTCCTTATTGGTGGTGGTATGACTTATACTTTCCTCAAGGCACAAGGTATCGAAATTGGTGATTCACTTGTTGAAGAAGACAAACTTGACATTGCTAAAGATCTTTTGGCTAAAGCAAATGGGAAATTAATCTTACCAGTTGACTCAAAAGAAGCTAATGCTTTTGCTGACTACACTGAAGTTAAAGATACTGAAGGTGCGGCTGTTGATCCAGGTTTCCTTGGTCTTGATATCGGTCCAAAATCAATTGCTAAATTTGATGATGAATTAACAGGTGCTAAGACAGTTGTTTGGAATGGTCCTATGGGTGTCTTTGAAAATCCTGATTTCCAAGCTGGGACAATCGGTGTGATGGATGCTATCGTCAAACAACCAGGTGTTAAATCAATCATCGGTGGTGGTGACTCAGCTGCTGCAGCCATCAACCTTGGCCGCGCAGATAAATTCTCATGGATTAGTACGGGTGGAGGTGCAAGCATGGAATTGCTTGAAGGAAAGGTACTCCCAGGCCTCGCTGCACTCACGGAAAAATAA","5.10","-8.00","42033","MAKLTVKDVDLKGKKVLVRVDFNVPVKDGVITNDNRITAALPTIKYIIEHGGRAVLFSHLGRVKEEADKKGKSLAPVAADLAKKLVQEVVFPGVTRGEQLEAAINALKNGEVLLVENTRFEDVDGKKESKNDPELGKYWASLGDGIFVNDAFGTAHRAHASNVGISANVDKAVAGFLLENEIAYIQEAVDNPVRPFIAILGGSKVSDKIGVIENLLKKADKVLIGGGMTYTFLKAQGIEIGDSLVEEDKLDIAKDLLAKANGKLILPVDSKEANAFADYTEVKDTEGAAVDPGFLGLDIGPKSIAKFDDELTGAKTVVWNGPMGVFENPDFQAGTIGVMDAIVKQPGVKSIIGGGDSAAAAINLGRADKFSWISTGGGASMELLEGKVLPGLAALTEK","340153","","phosphoglycerate kinase","Cytoplasm","Many matches in gapped BLAST to PGK sequences. Residues 22-398 are 88% similar to gi|15902485 from S.pneumoniae and 87% similar to gi|15675699 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1766 (0.0).","

InterPro
IPR001576
Family

Phosphoglycerate kinase
PR00477	$\"[10-26]T$ $\"[31-53]T$ $\"[110-125]T$ $\"[143-165]T$ $\"[174-196]T$ $\"[197-216]T$ $\"[316-341]T$ $\"[350-361]T$ $\"[373-390]T$	PHGLYCKINASE
PIRSF000724	$\"[3-398]T$	Pgk
PTHR11406	$\"[3-398]T$	PGK
PF00162	$\"[1-395]T$	PGK
PS00111	$\"[15-25]T$	PGLYCERATE_KINASE
SSF53748	$\"[2-397]T$	PGK

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1260	$\"[2-177]T$	G3DSA:3.40.50.1260
G3DSA:3.40.50.1270	$\"[184-398]T$	G3DSA:3.40.50.1270

","BeTs to 16 clades of COG0126COG name: 3-phosphoglycerate kinaseFunctional Class:� GThe phylogenetic pattern of COG0126 is amtkyqvcebrhujgpolin-Number of proteins in this genome belonging to this COG is 1","***** IPB001576 (Phosphoglycerate kinase family) with a combined E-value of 2.5e-144. IPB001576A 10-36 IPB001576B 54-63 IPB001576C 110-124 IPB001576D 145-165 IPB001576E 174-220 IPB001576F 256-276 IPB001576G 297-335 IPB001576H 351-395","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 16:00:54 2002","Thu Jan 17 15:56:05 2002","Thu Jan 17 16:00:54 2002","Thu Jan 17 15:56:05 2002","Thu Jan 17 15:56:05 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0326 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 17 16:00:54 2002","Thu Jan 17 15:56:05 2002","pdb|1VPE| Crystallographic Analysis Of Phosphoglycerate Kina... 364 1e-101pdb|1PHP| 3-Phosphoglycerate Kinase (Pgk) (E.C.2.7.2.3) 321 9e-089pdb|1QPG| 3-Phosphoglycerate Kinase, Mutation R65q 296 3e-081","SMU.361","","Residues 1 to 398 (E-value = 5.4e-186) place SMu0326 in the PGK family which is described as Phosphoglycerate kinase (PF00162)","Thu Jan 17 15:56:05 2002","24378858","","","Branny,P., de la Torre,F. and Garel,J.R.An operon encoding three glycolytic enzymes in Lactobacillusdelbrueckii subsp. bulgaricus: glyceraldehyde-3-phosphatedehydrogenase, phosphoglycerate kinase and triosephosphateisomeraseMicrobiology 144 (Pt 4), 905-914 (1998)PubMed: 9579064Crowhurst G, McHarg J, Littlechild JA.Phosphoglycerate kinases from bacteria and archaea.Methods Enzymol. 2001;331:90-104. No abstract available.PMID: 11265486","","Thu Jan 17 16:04:57 2002","1","","","SMU.361","182" "SMu0327","340543","341061","519","ATGAAAAAATATCATTTTGATCTCCAAAAATTTACATTGGGTATGCGGACTTTTAAATCGGGTTTAGCTGTTTTTTTAGTGCTTTTACTTTTTGGTATACTTGGCTGGAAAGGCCTTCAAATTGGTGCTTTAACGGCTGTTTTTAGTTTACGTGAGGATTTTGATAAAAGCATCCATTTTGGGACGTCACGTATAGTTGGTAATAGTATTGGCGGGGTTTATTCACTGCTATTTTTTCTCATCAATAATCTATTTCACTTTCAGTATTGGGTTACAGTTGTTTTTGTTCCAATATTTACCATGTTAACCATTATGACTAATGTGGCCATGAGTAATAAGACGGGAATTATTGGTGGTGTTGCAGCTTTGCTTATTATTACGCTTTCTATTCCCAAAGATGAAACAATTCTTTATGTTTGTGCTAGAGTTTTTGAAACTTTTGTAGGGGTTTTTATTGCCATTTCTGTTAATTCAGATATTGATAGAGTACGAAAATTTTTTACAAAAAGTAAAGTTTAG","10.60","8.65","19294","MKKYHFDLQKFTLGMRTFKSGLAVFLVLLLFGILGWKGLQIGALTAVFSLREDFDKSIHFGTSRIVGNSIGGVYSLLFFLINNLFHFQYWVTVVFVPIFTMLTIMTNVAMSNKTGIIGGVAALLIITLSIPKDETILYVCARVFETFVGVFIAISVNSDIDRVRKFFTKSKV","341058","In S.intermedius this gene is said to be homologous to the PAc of S.cricetus (see Tamura et al., 2001).","Streptococcus-specific protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to streptococcal spp. Residues 2-171 are 55% similar to gi|15900414 from S.pneumoniae. Residues 1-169 are 50% similar to gi|15675698 from S.pyogenes. Residues 2-100 are 57% similar to gi|14571815 from S.intermedius.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1765 (5e-45).","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[1-145]T$	no description

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[22-44]?$ $\"[65-85]?$ $\"[89-109]?$ $\"[111-131]?$ $\"[137-157]?$	transmembrane_regions

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PF00376	$\"[14-50]T$	MerR
SM00422	$\"[13-81]T$	HTH_MERR
PS00552	$\"[16-38]?$	HTH_MERR_1
PS50937	$\"[12-80]T$	HTH_MERR_2

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[13-108]T$	Putativ_DNA_bind

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[13-108]T$	G3DSA:1.10.1660.10

","BeTs to 7 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 6.7e-21. IPB000551A 15-36 IPB000551B 37-78","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 17 16:49:39 2006","Thu Jan 17 16:21:22 2002","Mon Jul 17 16:49:39 2006","Wed Apr 3 11:00:35 2002","Thu Jan 17 16:21:22 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0328 is paralogously related (blast p-value < 1e-3) to SMu1918, SMu0663, and SMu1174, all predicted transcriptional regulators.","Thu Jan 17 16:27:32 2002","","No significant hits to the NCBI PDB database.","SMU.363","","Residues 14 to 50 (E-value = 3e-14) place SMu0328 in the MerR family which is described as MerR family regulatory protein (PF00376)","Thu Jan 17 16:21:22 2002","24378860","","","Nakano,Y., Kato,C., Tanaka,E., Kimura,K. and Horikoshi,K.Nucleotide sequence of the glutamine synthetase gene (glnA) and its upstream region from Bacillus cereusJ. Biochem. 106 (2), 209-215 (1989)PubMed: 2572584Nakano,Y. and Kimura,K.Purification and characterization of a repressor for the Bacilluscereus glnRA operonJ. Biochem. 109 (2), 223-228 (1991)PubMed: 1677938","","Wed Apr 3 11:00:35 2002","1","","","SMU.363","857" "SMu0329","341554","342900","1347","ATGGCAATCACAGCAGCAGACATCCGTCGTGAAGTTAAAGAAAAGAATGTTACTTTCCTTCGTTTAATGTTTACGGATATCTTGGGAACCATGAAAAATGTTGAAATCCCAGCTACTGACGAACAATTAGACAAAGTACTTTCAAACAAAGCGATGTTTGATGGCTCTTCAATTGAAGGTTTTGTACGTATTAATGAATCAGACATGTATCTTTATCCTGACCTTAATACTTGGACTGTTTTTCCTTGGGGAGATGAAAACGGAGCCGTTGCTGGATTAATTTGTGATATTTATACAGCAGAAGGAGAACCATTTGCCGGTGACCCACGTGGTAACTTGAAAAAAGCACTGCGTCATATGGAAAGTCTAGGTTATAAATCGTTTAACCTCGGTCCAGAACCTGAGTTTTTCCTTTTCAAAATGGATGAATTTGGTAATCCGACAACAGAAGTAAATGATAAAGGTGGTTACTTTGATTTAGCACCAACTGACCTTGCTGATAATACCCGTCGTGAGATTGTCAATGTCTTAACAAAAATGGGATTTGAAGTTGAAGCAAGTCATCATGAAGTGGCTATTGGTCAACATGAAATTGATTTTAAATATGCAGATGTTTTAACTGCCTGTGATAAAATCCAACTTTTCAAATTAGTTGTTAAAACGATTGCCCGTAAACATGGTTTGTATGCAACCTTTATGGCCAAACCTAAATTTGGTATTAATGGCTCAGGGATGCACTGTAATATGTCTCTGTTTGGCAGTGATGGTAAGAACGCTTTCTTTGATCCACAAGATCCTAAAGGGATGCAGTTATCTGAAGTTGCTTATCAATTCTTAGGTGGTTTGGTAAAACATGCTTATAGCTATACTGCTATCATGAATCCAACTGTTAATTCATATAAACGTTTGGTTCCTGGTTATGAAGCTCCAGTCTATATTGCTTGGGCGGGACGCAATCGTTCACCGTTGATTCGTGTTCCAGCTTCACGTGGTGTTAGTACACGCCTGGAGTTGCGTTCGGTTGATCCTACAGCTAATCCTTATTTAGCTTTGGCTGTTCTTTTAGAATCTGGTCTTGATGGCATTGAAAATAAAATTGAAGCACCAGCACCTGTAGAATCAAATATTTATGTTATGACTGTTGAAGAACGCAAAGAAGCAGGTATTGCAGATCTTCCATCAACTCTTCATAATGCTCTGAAAGCATTACAAGAAGATGAAGTGGTTAAAGCAGCCTTAGGCAACCATATTTATACAAGTTTTCTTGAGGCAAAACGTATTGAATGGTCAAGCTATGCTGCTTTTGTATCGCAATGGGAAGTTGACAACTATTTGGATCTTTATTAA","5.00","-13.93","49944","MAITAADIRREVKEKNVTFLRLMFTDILGTMKNVEIPATDEQLDKVLSNKAMFDGSSIEGFVRINESDMYLYPDLNTWTVFPWGDENGAVAGLICDIYTAEGEPFAGDPRGNLKKALRHMESLGYKSFNLGPEPEFFLFKMDEFGNPTTEVNDKGGYFDLAPTDLADNTRREIVNVLTKMGFEVEASHHEVAIGQHEIDFKYADVLTACDKIQLFKLVVKTIARKHGLYATFMAKPKFGINGSGMHCNMSLFGSDGKNAFFDPQDPKGMQLSEVAYQFLGGLVKHAYSYTAIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLIRVPASRGVSTRLELRSVDPTANPYLALAVLLESGLDGIENKIEAPAPVESNIYVMTVEERKEAGIADLPSTLHNALKALQEDEVVKAALGNHIYTSFLEAKRIEWSSYAAFVSQWEVDNYLDLY","342897","For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0741 (glnH);SMu1080 (glnP);SMu1509 (glnB); SMu1380 (glnQ);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP). ","glutamine synthetase type 1","Cytoplasm","Matches in gapped BLAST to glnA sequences. Residues 1-448 are 89% similar to gi|15900416 from S.pneumoniae and 85% similar to gi|15675696 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1763 (0.0).","

InterPro
IPR004809
Family

Glutamine synthetase type I
TIGR00653	$\"[6-446]T$	GlnA

InterPro
IPR008146
Domain

Glutamine synthetase, catalytic region
PD001057	$\"[114-375]T$	Gln_synt_C
PF00120	$\"[106-362]T$	Gln-synt_C

InterPro
IPR008147
Domain

Glutamine synthetase, beta-Grasp
PF03951	$\"[16-100]T$	Gln-synt_N
PS00180	$\"[53-71]T$	GLNA_1
SSF54368	$\"[4-106]T$	Gln_synt_beta

InterPro
IPR014746
Domain

Glutamine synthetase/guanido kinase, catalytic region
G3DSA:3.30.590.10	$\"[109-447]T$	ATP-gua_Ptrans

noIPR
unintegrated

unintegrated
G3DSA:3.10.20.70	$\"[1-108]T$	G3DSA:3.10.20.70
PTHR20852	$\"[19-446]T$	PTHR20852
PTHR20852:SF7	$\"[19-446]T$	PTHR20852:SF7
SSF55931	$\"[106-447]T$	SSF55931

","BeTs to 12 clades of COG0174COG name: Glutamine synthaseFunctional Class: EThe phylogenetic pattern of COG0174 is amtkyqvCEbRhuj------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001637 (Glutamine synthetase class-I adenylation site) with a combined E-value of 2.3e-189. IPB001637A 6-37 IPB001637B 47-83 IPB001637C 112-144 IPB001637D 145-196 IPB001637E 215-262 IPB001637F 268-298 IPB001637G 299-327 IPB001637H 330-383 IPB001637I 436-446***** IPB001691 (Glutamine synthetase) with a combined E-value of 7.1e-43. IPB001691A 51-63 IPB001691B 129-138 IPB001691C 148-159 IPB001691D 166-213 IPB001691E 241-250 IPB001691G 335-348","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 12:21:59 2002","Thu Jan 17 16:28:32 2002","Thu Jan 17 16:33:54 2002","Mon Mar 25 15:36:07 2002","Thu Jan 17 16:28:32 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0329 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 17 16:33:54 2002","Thu Jan 17 16:28:32 2002","pdb|1F52|A Chain A, Crystal Structure Of Glutamine Synthetase F... 284 2e-077","SMU.364","","Residues 16 to 101 (E-value = 2.8e-40) place SMu0329 in the Gln-synt_N family which is described as Glutamine synthetase, beta-Grasp domain (PF03951)Residues 106 to 362 (E-value = 5.7e-143) place SMu0329 in the Gln-synt_C family which is described as Glutamine synthetase, catalytic domain (PF00120)","Thu Jan 17 16:28:32 2002","24378861","","Suvorov,A.N., Flores,A.E. and Ferrieri,P.Cloning of the glutamine synthetase gene from group B streptococciInfect. Immun. 65 (1), 191-196 (1997)PubMed: 8975911","Nakano,Y., Tanaka,E., Kato,C., Kimura,K. and Horikoshi,K.The complete nucleotide sequence of the glutamine synthetase gene(glnA) of Bacilus subtilisFEMS Microbiol. Lett. 57, 81-86 (1989)Nakano,Y. and Kimura,K.Purification and characterization of a repressor for the Bacilluscereus glnRA operonJournal of biochemistry. 109 (2), 223-228 (1991)PubMed: 1677938","Mon Mar 25 15:36:07 2002","Wed Apr 3 11:07:48 2002","1","","","SMU.364","181" "SMu0330","343060","347577","4518","ATGAGAGAGGTTATTAAAAAAGCTAAGCAGACGACTTTGTGGGATCCATCTTTTGAGACAGATGCCTGTGGGATGGGCTTTGTTGCTCAAATTGATGGTATTGCCAGTCATCAGTTAGTGGATTATGCCTTAACGATGTTAGAGAGAATGAACCACCGTGGAGGTACAGGTGCAGAGCCTGATACAGGAGATGGTGCTGGTATGTTGTTGGCCATGCCAGATGAGTTCTTTAGATTGAAGGCTAAAGAAGAAGAGATTGATTTACCACCATTGGGAGATTATGCTGTTGCCCAATTGTTTCTTCCTCAAGATAAAGTAGCAAAAACAATTTTAGAAGATAGTTTGATTAGTGAAATCAAAAGATTAGGCTTTCATGTATTGCTGTCGCGTGATGTTCCTTTCAATTATGACAACTGTGGTCCAGCTGCTCAGGAAATCATGCCAAGTTTTGTGCAGCTTTTTATTGAAAAACCTACTGAAACAAATAGTGGGTGTGCTTTTGAAGATAGTCTTTTCCGTCTGCGCCGCAAGTTGGAAAAAACGTTTGCTGCAGATGAACTTTTTATTTGTTCCTTATCAAGCAAGACGATTGTTTATAAGGGAATGCTGCATGCTTTTCAGGTTCGTCTGTTTTATCCTGACTTGTCAGATGAAATGTTCAAATCACACATTGCTTTAACACATTCTCGCTTTTCAACAAATACTTTCCCATCTTGGGATCGTGCTCAGCCTTTCCGCTTCTTAGCGCATAATGGAGAAATCAACACGCTTCGTGGTGCTGAAAATTGGATGCATAGTCATCAAATTGAAGTCTACAATGAAGAAAATTCAGACTCTGCTAAATTAGAAAACTGTCTAGAATATCTCTATCGTCATGGTCGTGATATTCCGCAAAGCTTATTGATGATGGTACCTGAAGCTTGGGGGAAAGATGCAGGACTTTCTAAAGAATTAACAGCCTTTTATGAATATGCTTCCAGTTTTGTCGCTCCTTGGGATGGCCCAGCCGCTCTCGTTTTCACTGATGGTGAGATGGTTGGAGCTCGTTTGGATCGTAATGGTCTTCGTCCTAGCCGCTATTCTCGCACCAAAGATAATTTTTTAATTTGCTCTAGCGAATCGGGTGTCGTTGATATAGCACCTAGTCAGGTTGTTGAAAAAGGGGTCCTTGGTCCCGGCAATATGATGTTAATTGATACCAAAAAAAACTTGGTATTAAAGAATGATGAGGTTAAAGAGCATTATTCTAAACAACACCCTTATCAACAGTGGGTGCAAGAAAATGTTACTCTTTTGGATGACTTTGCTGCTCAAGAGGAAATTGTCAATGATTATGATGTGAACCAAATGTGGAAAATTTTTGGTTATACAGATGAAACCATTCGAACAGTTATTCTCCCCATGTCAGAAAAAGGAGAGGAACCTGTTATTTCAATGGGCTTTGACAGTCCATTAGCAGTATTATCGAAAAAACCACAGTCTCTCTTTACTTACTTTAAGCAACAATTTGCTCAGGTAACCAATCCTCCTATTGATGCTATTCGTGAGCAATTAGTGGTGTCAACGACAGTCTTTTTAGGCGGTGATGGCGATATTCGTCAAGATAATGCTGATAATTGTGTCAAGGTTCGAGTTGACAGTCCTGTCCTTTCTAGTCAAGATTTTGCAAAATTAGCCAATTTAACAGATGAACGTTACAAGGCAACAACTCTATCCACTGTTTATGACTTAGGAGATTCTGACAATAATCGCCTGCAATATGCTTTGGAAGATCTTTTCAAAAAAGCTGATGAAGCAATTAATCAAGGCAGTAAGATCATCATTTTGTCAGACCGTGGAGTCACTAAAGGTCGCATAGCCATTCCTATTTTGTTGGCAGTTTCCGGTTTGAATAATTACATGGTTGTCAAAGGAAAAGCAAGTCAATTTTCAATTGTTGTTGATACGGCGGAAGCTTTTGAAGTTCATCATTTTGCAACCTTGGTTGGTTTTGGTGCAACAGCTATTCATCCTTATGGGGCTTATGCAACTCTAAAAGCTTTTGATAAGACCAATGACTCTTTTGAAAAATATCGTAAGGCTGCCGAAAAGGGCATTGTTAAAGTCATGAGTCGTATGGGAATTTCAACAGTACTCGGATATAAAGGTGCTCAGCTTTTTGAAGCCATTGGTCTTTCTGCTGATGTTGTTAACCAATACTTTAGAGGAACAGCTACGCGTATTGAAGGTTTGAGTCTGAAGCAAATTGAAAAAGAATACCTAGAACGCGTTGATTTCGCCTTTGGACCGAGAGCCAATGATTTCTTGCCTTCTGGTGGTTCCTATCAGTATAAGACAGATGGAGAGTATCACCTCTTTAATCCACGCTCTATCTATAATTTCCAACAATCCATTCGTCGTGGTGACTATGGTCTCTTTAAACAATATTCAACTGAACTAGATAATGAGGCCTTAAAACAACCGACGACCCTGCGTTCTCTTTGGGAATTTCATTCTAAACGACCAAAAGTTGATTTAGCAGAAGTTGAGCCTGCTAAGGAAATTGTTAAGCGTTTTAAGGTTGGTGCCATGAGTTTTGGCTCTCTTTCTAAAGAGGCGCATGAAACCATTGCTCAAGCGATGAATACTATCGGAGCTAAATCAAATTCTGGTGAAGGCGGTGAAAATCGCAAACGCTTCAAACCGCAAGTTGATGGTCGCAATATTAATTCTAAAATTAAGCAAGTTGCTTCCGGACGGTTTGGTGTTAATGCAGAATACCTTATGTCTGCAGAAGAATTGCAAATCAAATTAGCACAAGGAGCTAAGCCTGGTGAAGGCGGACAACTTCCCGGTCAAAAGGTCTTTCCTTGGATTGCTGAAATTCGCGGAGCAACCCCAGGTGTGCGCTTGATTTCACCACCACCTCATCATGATATTTATTCCATTGAAGACCTAGCACAATTAATTTATGATTTGAAAGCTATCAATCCTTATGCCAAAATCAATGTTAAATTAGTATCAAGTACAGGTGTTGGTACGATTGCTACGGGCTGTGTTAAAGCGGGTGCTGATAAGGTGGTTATTTCAGGTTATGATGGTGGTACAGGTGCCTCTCCTCGTAATTCTGTTCGTGATGCGGGGCTTCCATGGGAAATGGGCTTGGCTGAAGCTCATCAGACCTTGTCTATGAATCGTCTTCGTCAACGTATGACTTTGGAAACAGATGGAAAATTAATGACGGGTCGCGATATTGCTATTGCTACTTTATTGGGTGCAGAAGAATATTCATTTGCTAGTCTAGCTTTGATTTCAGTTGGATGTGTCATGATGCGTGTTTGTTCACTTAATACTTGTCCTGTCGGTGTCGCAACACAAAATCCAGAATTACGTAAAAACTTCTCAGGCAAGCCAGAACATGTGATTAACATGATGACTTTCTTGGCAGAAGAATTACGTGAATACATGGCTGAGTTAGGTTTCCGCTCTGTTGATGAAATGGTTGGTCATGCAGAAGTTTTGAAATCGAGATTTGTTGCACAAGGTAAGGCAAAATCTCTTAATTTTTCAAGGGTTATTGGGAACAGTTTCCCAATTGATCGGAAAAATGAAGATCCTTTTGCTGAAGAACGTCAATGGAAAGAACTGGATGGTTTTGCAGCAGCAGCTATTGAAAAAGGCATTAGTGTTACTATTGAAAATACCATCAATAATGTGGACCGTTCAGTAGGGAGTCGCATGGCTGGTTGGATGGCAGAACGTTATGGTAATGACGCTGTTAAAGAAGGTTTAATTAAATATCATTATACTGGCATTGCAGGGCAAAGTTTTGCGAGTTACCTTACACAAGGTTTAGAGTATACCTTGATTGGTGAGGCTAATGACTATATTGCTAAATCTATGTCAGGTGGACGCTTAATTGTCAAACCGCCGCACGACGCAGCCTACGACGTTGAAAATTCACCAATTGTTGGTAATGTCTCTCTCTTTGGTGCTGTCAAAGGTGAAGCTTATTTTGCAGGTCGTGCTGGTGAGCGTTTCTGTGTTCGTAATTCAGGAGCAAAAGTCGTTGTTGAAGGTGTCGGTGCTCACGGTTGTGAGTATATGACTGGCGGTGTAGCTGTCATTCTTGGAACGACAGGTCGCAACTTTGCTGCTGGTATGAGTGGTGGTGTTGCCTATGTTTACGATGTTCATGGTGATTTTGCTCAAAAAGTCAATATGGAGATGGTAGATCTTTATCAGATTGGTGAAACTCGTGGTGATGACATCTTAAAAGACATGATTGAAAAGCACTATGAATATACAGAAAGTGTTAAGGCCAAACGTCTTTTGGATAATTGGGATGAAGAGGTGAAAAGATTTATCAAAGTTTATCCAAGTGATTTCCATGAAATTAATGATATTGAATATGCTCTCAGCCAAAAAGGCATGAGTGGTGATGAACTCGAATTACGTACATTTGAAGTAGCAACTGGCGGCGATGCTACAGCGCAAGAGCGTCAAGCTTTGTTGGCTAGTGTAACAGGAGGGAAATGA","5.70","-24.43","166636","MREVIKKAKQTTLWDPSFETDACGMGFVAQIDGIASHQLVDYALTMLERMNHRGGTGAEPDTGDGAGMLLAMPDEFFRLKAKEEEIDLPPLGDYAVAQLFLPQDKVAKTILEDSLISEIKRLGFHVLLSRDVPFNYDNCGPAAQEIMPSFVQLFIEKPTETNSGCAFEDSLFRLRRKLEKTFAADELFICSLSSKTIVYKGMLHAFQVRLFYPDLSDEMFKSHIALTHSRFSTNTFPSWDRAQPFRFLAHNGEINTLRGAENWMHSHQIEVYNEENSDSAKLENCLEYLYRHGRDIPQSLLMMVPEAWGKDAGLSKELTAFYEYASSFVAPWDGPAALVFTDGEMVGARLDRNGLRPSRYSRTKDNFLICSSESGVVDIAPSQVVEKGVLGPGNMMLIDTKKNLVLKNDEVKEHYSKQHPYQQWVQENVTLLDDFAAQEEIVNDYDVNQMWKIFGYTDETIRTVILPMSEKGEEPVISMGFDSPLAVLSKKPQSLFTYFKQQFAQVTNPPIDAIREQLVVSTTVFLGGDGDIRQDNADNCVKVRVDSPVLSSQDFAKLANLTDERYKATTLSTVYDLGDSDNNRLQYALEDLFKKADEAINQGSKIIILSDRGVTKGRIAIPILLAVSGLNNYMVVKGKASQFSIVVDTAEAFEVHHFATLVGFGATAIHPYGAYATLKAFDKTNDSFEKYRKAAEKGIVKVMSRMGISTVLGYKGAQLFEAIGLSADVVNQYFRGTATRIEGLSLKQIEKEYLERVDFAFGPRANDFLPSGGSYQYKTDGEYHLFNPRSIYNFQQSIRRGDYGLFKQYSTELDNEALKQPTTLRSLWEFHSKRPKVDLAEVEPAKEIVKRFKVGAMSFGSLSKEAHETIAQAMNTIGAKSNSGEGGENRKRFKPQVDGRNINSKIKQVASGRFGVNAEYLMSAEELQIKLAQGAKPGEGGQLPGQKVFPWIAEIRGATPGVRLISPPPHHDIYSIEDLAQLIYDLKAINPYAKINVKLVSSTGVGTIATGCVKAGADKVVISGYDGGTGASPRNSVRDAGLPWEMGLAEAHQTLSMNRLRQRMTLETDGKLMTGRDIAIATLLGAEEYSFASLALISVGCVMMRVCSLNTCPVGVATQNPELRKNFSGKPEHVINMMTFLAEELREYMAELGFRSVDEMVGHAEVLKSRFVAQGKAKSLNFSRVIGNSFPIDRKNEDPFAEERQWKELDGFAAAAIEKGISVTIENTINNVDRSVGSRMAGWMAERYGNDAVKEGLIKYHYTGIAGQSFASYLTQGLEYTLIGEANDYIAKSMSGGRLIVKPPHDAAYDVENSPIVGNVSLFGAVKGEAYFAGRAGERFCVRNSGAKVVVEGVGAHGCEYMTGGVAVILGTTGRNFAAGMSGGVAYVYDVHGDFAQKVNMEMVDLYQIGETRGDDILKDMIEKHYEYTESVKAKRLLDNWDEEVKRFIKVYPSDFHEINDIEYALSQKGMSGDELELRTFEVATGGDATAQERQALLASVTGGK","347574","For the small subunit, see SMu0331.For other 'glt' genes see SMu0741 (gltS); SMu0296 (gltX) and SMu0331 (gltD).","glutamate synthase, large subunit","Cytoplasm","Matches in gapped BLAST to glutamate synthase sequences (large subunit). Residues 1-1485 are 63% similar to gi|15673268 from L. lactis. Residues 9-1482 are 48% similar to gi|15614291 from B.halodurans.SMu0330 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000583
Domain

Glutamine amidotransferase, class-II
PF00310	$\"[23-374]T$	GATase_2

InterPro
IPR002489
Domain

Glutamate synthase, alpha subunit, C-terminal
PF01493	$\"[1225-1428]T$	GXGXG
SSF69336	$\"[1197-1466]T$	Glu_synthase_C

InterPro
IPR002932
Domain

Glutamate synthase, central-C
PF01645	$\"[784-1155]T$	Glu_synthase

InterPro
IPR006982
Domain

Glutamate synthase, central-N
PF04898	$\"[447-727]T$	Glu_syn_central

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[427-774]T$ $\"[776-1186]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
G3DSA:3.60.20.10	$\"[23-428]T$	G3DSA:3.60.20.10
PIRSF000186	$\"[12-1475]T$	FdGOGAT_GOGAT_lg
PIRSF500059	$\"[12-1476]T$	GOGAT_lg
PTHR11938	$\"[13-459]T$ $\"[665-1460]T$	PTHR11938
PTHR11938:SF1	$\"[13-459]T$ $\"[665-1460]T$	PTHR11938:SF1
SSF51395	$\"[418-1192]T$	SSF51395
SSF56235	$\"[23-428]T$	SSF56235

","BeTs to 10 clades of COG0069COG name: Glutamate synthetase domain 2Functional Class: EThe phylogenetic pattern of COG0069 is amT-yqVCeBr----------Number of proteins in this genome belonging to this COG is 1","***** IPB002932 (Conserved region in glutamate synthase) with a combined E-value of 0. IPB002932A 19-59 IPB002932B 186-215 IPB002932C 224-268 IPB002932D 331-376 IPB002932E 484-534 IPB002932F 644-677 IPB002932G 698-745 IPB002932H 842-882 IPB002932I 904-948 IPB002932J 949-991 IPB002932K 1015-1052 IPB002932L 1053-1079 IPB002932M 1080-1118 IPB002932N 1262-1303 IPB002932O 1316-1345***** IPB002489 (Domain of unknown function DUF14) with a combined E-value of 2.5e-158. IPB002489A 228-267 IPB002489B 329-360 IPB002489C 851-884 IPB002489D 904-948 IPB002489E 960-997 IPB002489F 1266-1301","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 12:24:02 2002","Thu Jan 17 16:35:50 2002","Thu Jan 17 16:44:08 2002","Mon Apr 1 13:47:47 2002","Thu Jan 17 16:35:50 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0330 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 17 16:44:08 2002","","No significant hits to the NCBI PDB database.","SMU.365","","Residues 23 to 436 (E-value = 2.5e-237) place SMu0330 in the Glu_synth_NTN family which is described as Glutamate synthase amidotransferase domain (PF04897)Residues 447 to 727 (E-value = 2.2e-141) place SMu0330 in the Glu_syn_central family which is described as Glutamate synthase central domain (PF04898)Residues 784 to 1155 (E-value = 4.2e-211) place SMu0330 in the Glu_synthase family which is described as Conserved region in glutamate synthase (PF01645)Residues 1225 to 1421 (E-value = 2.3e-71) place SMu0330 in the GXGXG family which is described as GXGXG motif (PF01493)","Thu Jan 17 16:35:50 2002","24378862","","","Bohannon,D.E. and Sonenshein,A.L.Positive regulation of glutamate biosynthesis in Bacillus subtilisJ. Bacteriol. 171 (9), 4718-4727 (1989)PubMed: 2548995Goss TJ, Perez-Matos A, Bender RA.Roles of glutamate synthase, gltBD, and gltF in nitrogen metabolism of Escherichia coli and Klebsiella aerogenes.J Bacteriol. 2001 Nov;183(22):6607-19.PMID: 11673431Dincturk HB.Glutamate synthase: an archaeal horizontal gene transfer?J Biosci. 2001 Mar;26(1):13-4. No abstract available.PMID: 11255509","","Mon Apr 1 13:48:05 2002","1","","","SMU.365","" "SMu0331","347579","349015","1437","ATGGCAGATCCGTTTGGATTTTTAAAGTATGAGCGCAAGGACAATCCCTATCGTCCTGTTAATGAGCGTATCAAAGATTTTGAAGAATTGCAGACAACTTTATCAGTTGAGGAACGTCAAAAGCAAGCTGCTCGCTGTATGAATTGTGGGATCCCTTTCTGTCATGAGGGAACTTTCTATGGTGGCGGTCGTGCTGTTTCAGGTTGTCCCAATGACAATTTAATCCCTGAATGGAATGATTTGATTTATAAGGGCGATTTCAGACGTGCTTTTGAACGCTTGACACGAACTAACCCTTTACCAGAAATGACAGGTCGTGTCTGCCCGGCACCTTGTGAAAAGGCCTGTACAGAAGGCTTAAATGGTTCGGGTGTTACCATTCATGATAATGAACGTTTTATTATTGATAATGCATTTGAAGAAGGCTGGGTAGCTGATTCTGGTCGCCCTATTGAGCGTACAGGTTTTAAAGTAGCTGTCGTAGGTTCAGGTCCTGCTGGCCTGTCAGCTGCTTGGCGTCTTAACCAGTTGGGTCACAGTGTAACTGTGTTTGAGCGTTCTGATCGCTTTGGTGGTTTGCTCATGTATGGTATTCCCAATATGAAATTGGATAAGAAAATTGTGCAACGCCGTATTGATACGATGGCTTCAATTGGTATTAATTTTGTTGCCAATACAGAAATTGGTCGTGATATTACAGCAGAAGAATTATTAGAAAAATTTGACCGTGTAATCTTGGCAACTGGAGCTAGCGTTCCTCGTGACTTGGATATTCCAGGCCGTGACTTAAAAGGCATTCGATTTGCTGTTGATTTCTTAACAGAAACGACTAAAAATCTTTTGGACAGTGACACACACGAATTACCGCCCTTGCTTGAAGGAAAACATGTCTTAGTTATTGGCGGTGGCGATACTGGAAATGACTGTATCGGTACGGCTGTTCGTTTGGGAGCTGCTAGTGTTAGACAATTAGAAATTACGCCGCAACTGCCTGAAAAGCGTCTGCCAACAAATCCATGGCCACAATATCCTATGATTAATCGTACAGGCTATGGACAGGAAGAAGCCGATTTTGTTCAACAGACTGATTTGACGGACTATATCACGTCAACAGTAGAATTTCTTGGTGAAAATGGCCAAGTGACTGCGGTGAAGACAATTAAGGTTGGACCTGGTTTCAAAGCCATTGAAGGAACTGAAGAGGTAATTAAGGCAGATCTTGTTCTTCTTGCTATGGGCTTCACAGGTGCTGAAAAAGCGCTCTTTGACCAATTCCGAGTTGAATGTGTTTATGATGACTATTCAACTCGAAATGAGAAGGTTTTTGTTGCAGGTGATGCACGCCGTGGTCCTAGTCTTGTTATTTGGGGAATTCGAGAAGGACGCAAAACAGCAGAGAAAATTGATCAAAACCTCAGAATGATGGTTACAGAGTGA","5.10","-11.17","53070","MADPFGFLKYERKDNPYRPVNERIKDFEELQTTLSVEERQKQAARCMNCGIPFCHEGTFYGGGRAVSGCPNDNLIPEWNDLIYKGDFRRAFERLTRTNPLPEMTGRVCPAPCEKACTEGLNGSGVTIHDNERFIIDNAFEEGWVADSGRPIERTGFKVAVVGSGPAGLSAAWRLNQLGHSVTVFERSDRFGGLLMYGIPNMKLDKKIVQRRIDTMASIGINFVANTEIGRDITAEELLEKFDRVILATGASVPRDLDIPGRDLKGIRFAVDFLTETTKNLLDSDTHELPPLLEGKHVLVIGGGDTGNDCIGTAVRLGAASVRQLEITPQLPEKRLPTNPWPQYPMINRTGYGQEEADFVQQTDLTDYITSTVEFLGENGQVTAVKTIKVGPGFKAIEGTEEVIKADLVLLAMGFTGAEKALFDQFRVECVYDDYSTRNEKVFVAGDARRGPSLVIWGIREGRKTAEKIDQNLRMMVTE","349012","For the large subunit, see SMu0330.For other 'glt' genes see SMu0741 (gltS); SMu0296 (gltX) and SMu0330 (gltA),(gltB). ","glutamate synthase, small subunit","Cytoplasm, Extracellular","Matches in gapped BLAST to glutamate synthase small subunits. Residues 1-477 are 67% similar to gi15673267 from L.lactis. Residues 1-473 are 50% similar to gi5305491 from C.acetobutylicum. See also the similarity to SMu0762.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1834 (4e-06).","

InterPro
IPR000759
Family

Adrenodoxin reductase
PR00419	$\"[157-179]T$ $\"[180-193]T$ $\"[222-232]T$ $\"[297-311]T$	ADXRDTASE

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[157-179]T$ $\"[296-321]T$ $\"[441-448]T$	PNDRDTASEI

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[248-318]T$	FAD_pyr_redox
PF00070	$\"[157-190]T$	Pyr_redox

InterPro
IPR003042
Family

Aromatic-ring hydroxylase
PR00420	$\"[157-179]T$ $\"[438-453]T$	RNGMNOXGNASE

InterPro
IPR006005
Domain

Glutamate synthase, NADH/NADPH, small subunit 1
TIGR01317	$\"[3-475]T$	GOGAT_sm_gam

InterPro
IPR009051
Domain

Alpha-helical ferredoxin
SSF46548	$\"[4-166]T$	Helical_ferredxn

InterPro
IPR012285
Domain

Fumarate reductase, C-terminal
G3DSA:1.10.1060.10	$\"[33-142]T$	Fum_reductase_C

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[157-179]T$ $\"[296-321]T$ $\"[441-448]T$	FADPNR
PF07992	$\"[157-452]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[152-315]T$	G3DSA:3.40.50.720
PTHR11938	$\"[6-473]T$	PTHR11938
PTHR11938:SF9	$\"[6-473]T$	PTHR11938:SF9

","BeTs to 10 clades of COG0493COG name: NADPH-dependent glutamate synthase beta chain and related oxidoreductasesFunctional Class: E,RThe phylogenetic pattern of COG0493 is ---KYqVcEbR------l--xNumber of proteins in this genome belonging to this COG is 2","***** PR00419 (Adrenodoxin reductase family signature) with a combined E-value of 2.9e-26. PR00419A 157-179 PR00419B 180-193 PR00419C 222-232 PR00419D 297-311 PR00419E 334-347***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 2.5e-16. PR00368A 157-179 PR00368B 244-253 PR00368C 296-321 PR00368E 441-448***** IPB000171 (Bacterial-type phytoene dehydrogenase) with a combined E-value of 3.6e-12. IPB000171A 159-189***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 4e-08. IPB000103A 157-177 IPB000103C 262-310 IPB000103E 436-473***** PR00420 (Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature) with a combined E-value of 6.2e-07. PR00420A 157-179 PR00420C 438-453","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 24 08:26:45 2005","Tue May 24 08:26:45 2005","Tue May 24 08:26:45 2005","Mon Apr 1 13:48:38 2002","Thu Jan 17 16:54:06 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0331 is paralogously related (blast p-value < 1e-3) to SMu0762, a predicted glutathione reductase, and to SMu0116, a predicted dihydrolipoamide dehydrogenase, to SMu0732, an ABC element, and to SMu0162, an oxidoreductase.","Thu Jan 17 17:03:14 2002","Tue May 24 08:26:45 2005","pdb1E1LA Chain A, Structure Of Adrenodoxin Reductase In Compl... 68 3e-012","SMU.366","","Residues 157 to 456 (E-value = 7e-21) place SMu0331 in the Pyr_redox family which is described as Pyridine nucleotide-disulphide oxidoreductase (PF00070)","Thu Jan 17 16:54:06 2002","24378863","","","Bohannon,D.E. and Sonenshein,A.L.Positive regulation of glutamate biosynthesis in Bacillus subtilisJ. Bacteriol. 171 (9), 4718-4727 (1989)PubMed: 2548995Goss TJ, Perez-Matos A, Bender RA.Roles of glutamate synthase, gltBD, and gltF in nitrogen metabolism of Escherichia coli and Klebsiella aerogenes.J Bacteriol. 2001 Nov;183(22):6607-19.PMID: 11673431Dincturk HB.Glutamate synthase: an archaeal horizontal gene transfer?J Biosci. 2001 Mar;26(1):13-4. No abstract available.PMID: 11255509","","Mon Apr 1 13:48:38 2002","1","","","SMU.366","" "SMu0332","349163","349798","636","ATGAAAAAACAATTTTTGGAAAAAGCTGTGTTTACTGTTGCGGCTACGGCAGCAACAGTTGTTTTAGGAAATAAAATGGCTGATGCAGACACTTATACTCTTCAAGAAGGAGATTCTTTTTTCAGTGTTGCTCAACGATATCATATGGATGCTTATGAGTTAGCTTCTATGAATGGAAAAGATATTACCAGTCTGATTTTGCCGGGTCAGACTTTAACTGTTAATGGTTCGGCAGCACCGGATAATCAGGCGGCAGCGCCAACTGACACTACGCAAGCAACCACTGAAACGAATGATGCGAATGCCAATACTTATCCTGTTGGTCAATGTACTTGGGGGGTTAAAGCTGTTGCAACTTGGGCAGGCGACTGGTGGGGCAATGGCGGTGATTGGGCCTCTAGTGCTTCTGCACAAGGTTACACTGTCGGTAACACTCCGGCAGTAGGGTCTATTATGTGTTGGACAGATGGTGGTTATGGACATGTTGCCTATGTCACAGCTGTTGGTGAAGATGGTAAAGTTCAAGTACTGGAATCCAATTATAAAGATCAACAATGGGTTGATAACTATCGTGGTTGGTTTGATCCAAATAATAGTGGAACACCAGGCAGTGTCAGTTATATTTATCCTAACTAA","4.20","-10.62","22456","MKKQFLEKAVFTVAATAATVVLGNKMADADTYTLQEGDSFFSVAQRYHMDAYELASMNGKDITSLILPGQTLTVNGSAAPDNQAAAPTDTTQATTETNDANANTYPVGQCTWGVKAVATWAGDWWGNGGDWASSASAQGYTVGNTPAVGSIMCWTDGGYGHVAYVTAVGEDGKVQVLESNYKDQQWVDNYRGWFDPNNSGTPGSVSYIYPN","349795","","Streptococcus-specific protein; similar to glucan-binding protein","Extracellular","Limited hits in gapped BLAST to hypothetical proteins and glucan binding proteins. Residues 24-211 are 41% similar to >gi14571814 from S.intermedius. Residues 105-211 are 50% similar to residues 333-432 of the previously sequenced glycan binding B protein from S.mutans (gi15341186). See also gi15341188, gi12802877The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1762 (2e-35).","

InterPro
IPR002482
Domain

Peptidoglycan-binding LysM
PF01476	$\"[32-75]T$	LysM
SM00257	$\"[31-75]T$	LysM

InterPro
IPR007921
Domain

Cysteine, histidine-dependent amidohydrolase/peptidase
PF05257	$\"[90-209]T$	CHAP
PS50911	$\"[85-209]T$	CHAP

noIPR
unintegrated

unintegrated
G3DSA:3.10.350.10	$\"[28-77]T$	G3DSA:3.10.350.10
SSF54106	$\"[28-77]T$	SSF54106

InterPro
IPR001279
Domain

Beta-lactamase-like
PF00753	$\"[23-224]T$	Lactamase_B

InterPro
IPR001587
Domain

Protein of unknown function UPF0036
PS01292	$\"[366-394]T$	UPF0036

InterPro
IPR004613
Family

Conserved hypothetical protein MG423
TIGR00649	$\"[11-555]T$	MG423

InterPro
IPR011108
Domain

RNA-metabolising metallo-beta-lactamase
PF07521	$\"[356-396]T$	RMMBL

noIPR
unintegrated

unintegrated
G3DSA:3.60.15.10	$\"[32-167]T$	G3DSA:3.60.15.10
SSF56281	$\"[1-210]T$	SSF56281

InterPro
IPR009907
Family

Protein of unknown function DUF1447
PF07288	$\"[2-76]T$	DUF1447

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[133-175]T$	ABC_transporter
PF00005	$\"[31-208]T$	ABC_tran
PS50893	$\"[6-232]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-208]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-223]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-224]T$	PTHR19222
PTHR19222:SF16	$\"[6-224]T$	PTHR19222:SF16
SSF52540	$\"[4-224]T$	SSF52540

","BeTs to 11 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.5e-30. IPB001140A 20-66 IPB001140B 130-168 IPB001140C 185-214","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 09:53:42 2002","Fri Jan 18 17:09:07 2002","Tue Oct 29 09:53:42 2002","Sun Jan 20 21:45:22 2002","Fri Jan 18 17:09:07 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0335 is paralogously related (blast p-value < 1e-3) to SMu1649, SMu0216, SMu0596, SMu0976, SMu0950, SMu0390, SMu0944, SMu0884, SMu1762, SMu1920, SMu1518, SMu1380, SMu1093, SMu0374, SMu0971, SMu0517, SMu1079, SMu1003, SMu0418, SMu0849, SMu1410, SMu1210, SMu0731, SMu0594, SMu1246, SMu1231, SMu0218, SMu0786, SMu1517, SMu0666, SMu1949, SMu1757, SMu0916, SMu1050, SMu0476, SMu1288, SMu1037, SMu1036, SMu1068, SMu1545, SMu0752, SMu1950, SMu1023, SMu0805, SMu0164, SMu0907, SMu1751, SMu1428, SMu1316, SMu0825, SMu0475, SMu0235, SMu0258, SMu0837, SMu0234, SMu1065, SMu0986, SMu0836, SMu0824, SMu1710, SMu0823, SMu1959, SMu1811, SMu0987, SMu1064, SMu1001, SMu0024, SMu1724, SMu1306, SMu0224, and SMu0729.","Sun Jan 20 21:45:22 2002","Fri Jan 18 17:09:07 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 107 2e-024pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 72 7e-014","SMU.370","","Residues 31 to 208 (E-value = 1.1e-49) place SMu0335 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Jan 18 17:09:07 2002","24378867","","","","Tue Oct 29 09:53:42 2002","","1","","","SMU.370","" "SMu0336","353198","353911","714","ATGTTTAGACAATTTATGGCTCTTCTTTGGTTGCGATGTCAGATTATTCTTTCTAATAAGAGCATTCTCTTGCAAGTACTTATGCCTGCAGCTTTGATTTATCTTTATCGTTTTATGATAGACAGTCAGTCTGGTCCAAAAGCCCAAATGGCTCTTGCCTATCTGATGATCTGTATTCCTTTTGCCATTGTCCTAGCTGTAGGCAATCCAATTTTAACTATTTTGGCAGATGAAAAAGAAAAGAAAACACTAAAAACTCTGCTGCTTAGCGGTGTTAATACTAGTGAGTACCTCTTATCAACATTAGTTGTCCCAATTGTCTTAACAGTAGTCTATCTGACGCTTACTCCGCTTATTTTGGATGTGCCGATTGATCATTTAGTAAATTATTGTCTTGTCGGTAGCGCTACAGCTTTAGTAATCGCACTTCTCTACTTATTGTTAGGCTTACTTGTCAAATCACAAGTTATGGCCCAGGTTGTTGCGGTTCCAACGATGCTTATTTCAGCTTTCTTACCAATGTTATCTGGTATGGATAAAACCGTTGCCAAAGTGACAGACTATAGCTTTATGGGCCTTTTTACGAAGTTTTTTACCAAATGGGAAAAATTTTCTTGGCACCATGCCACCTTACAAATATTGAGTTTATTTATCTGGCTTTTGGTTCTTTTGATCCTAATTGTTACAGTAGCTAGACAACAAAAGAAAAGCTAG","10.20","8.56","26539","MFRQFMALLWLRCQIILSNKSILLQVLMPAALIYLYRFMIDSQSGPKAQMALAYLMICIPFAIVLAVGNPILTILADEKEKKTLKTLLLSGVNTSEYLLSTLVVPIVLTVVYLTLTPLILDVPIDHLVNYCLVGSATALVIALLYLLLGLLVKSQVMAQVVAVPTMLISAFLPMLSGMDKTVAKVTDYSFMGLFTKFFTKWEKFSWHHATLQILSLFIWLLVLLILIVTVARQQKKS","353908","For other components see SMu0335 (NBD1).","Streptococcus-specific protein; possible ABC transporter, membrane spanning permease","Membrane, Cytoplasm","This is a potential ABC transporter, membrane spanning permease.Single match in gapped BLAST to gi15900598 from S.pneumoniae. Residues 1-207 are 46% similar to this hypothetical sequence. SMu0336 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR013525
Domain

ABC-2 type transporter
PF01061	$\"[3-203]T$	ABC2_membrane

noIPR
unintegrated

unintegrated
SSF53335	$\"[19-234]T$	SSF53335

","BeTs to 8 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class:� RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 11:50:38 2002","Fri Jan 25 11:50:38 2002","Fri Jan 25 11:50:38 2002","Fri Jan 25 11:50:38 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0338 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 11:50:38 2002","","No significant hits to the NCBI PDB database.","SMU.373","","No significant hits to the Pfam 11.0 database","Fri Jan 25 11:50:38 2002","24378870","","","","","","1","","","SMU.373","" "SMu0339","355842","356552","711","ATGGGGAAGAATAATTTGCTTTTAATTGGTTCAGAAAGCCATATTTGTCAGGGCTTTTTGAAAAATTATTCCGAGGATTTTGATCAAATCGTTGGAATTGATTTTCCTAAAAAATCTAGCAGTTTAACAACGTACCTTTCTGTTGATTTTCGACAAGATGATTCTTTCCACAAGATGGAAACCTTTTTAAAAGAATTAGACCTAAACTTTTCCAGCGTTGTGTTTACTTCTGGTATTAATTATATGAATGATGCATTTGGAGTAACACTTAAGGACTGGGAAAACACATTTGATATTAATGTAAAGGCAGCTCTCTTTTCTATGAAGGCAATTTATAGCTATCTGTCTGACAAAGCTTCTATCGTTTTTATAGCTTCGCAAAATGGTGTTGTTGCTCACGAACAAAGAATAGATTATGGGCCTGCCAAAAGTGCCTTAATCCAATTGGCAAAAAATCTATCAGTTGATTACGCTAAAATAGAGGATAAGGATATCAGGGTCAATACAATCTCGCCTTCATATATCATTAATGATAGTAATAAGGAACTGTTATTTTCGAGCTTTGGGAAACGCTTATTAGCAAAGATTCCTTATAGGAAGTTTGTGACTGTTGAAGATGTTAGTCAGACACTATTTTTCCTTCTAAGTAAGAACAGCAGAGCTATGCGTGGACAAAATCTCATTTTAGATTATGGTTATACTATCATTTAG","6.80","-0.33","26738","MGKNNLLLIGSESHICQGFLKNYSEDFDQIVGIDFPKKSSSLTTYLSVDFRQDDSFHKMETFLKELDLNFSSVVFTSGINYMNDAFGVTLKDWENTFDINVKAALFSMKAIYSYLSDKASIVFIASQNGVVAHEQRIDYGPAKSALIQLAKNLSVDYAKIEDKDIRVNTISPSYIINDSNKELLFSSFGKRLLAKIPYRKFVTVEDVSQTLFFLLSKNSRAMRGQNLILDYGYTII","356549","","oxidoreductase/ dehydrogenase","Cytoplasm","Limited hits in gapped BLAST to dehydrogenase/reductase sequences. Residues 7-235 are 25% similar and 24% similar to gi|16802389 and gi|16799439 from L.monocytogenes and L.inocua. Residues 73-235 are 30% similar to residues 94-255 of gi|16123501| in Y.pestis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0664 (2e-11).","

InterPro
IPR002198
Family

Short-chain dehydrogenase/reductase SDR
PTHR19410	$\"[73-232]T$	ADH_short_C2

InterPro
IPR002347
Family

Glucose/ribitol dehydrogenase
PR00081	$\"[113-129]T$ $\"[139-158]T$ $\"[163-180]T$ $\"[197-217]T$	GDHRDH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-233]T$	G3DSA:3.40.50.720
PTHR19410:SF62	$\"[73-232]T$	PTHR19410:SF62
SSF51735	$\"[2-235]T$	SSF51735

noIPR
unintegrated

unintegrated
tmhmm	$\"[93-115]?$ $\"[125-145]?$ $\"[196-216]?$ $\"[222-240]?$ $\"[274-294]?$	transmembrane_regions

","BeTs to 3 clades of COG1994COG name: Zn-dependent proteasesFunctional Class:� RThe phylogenetic pattern of COG1994 is aMT--qvc-BR-uj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 12:00:17 2002","Fri Jan 25 12:00:17 2002","Fri Jan 25 12:00:17 2002","Fri Jan 25 12:00:17 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0340 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 12:00:17 2002","","No significant hits to the NCBI PDB database.","SMU.375","","No significant hits to the Pfam 11.0 database","Fri Jan 25 12:00:17 2002","24378872","","","","","","1","","","SMU.375","" "SMu0341","357487","358725","1239","ATGAAAAATTATGCTTTGCTAAACGGTGCTTATGATAATAAAACCATGTATGATTTCAAGCCCGTCAGGGCAGATAACACTTATTTATATGATAGTCAAAATAGGAAGTATCTTGATTTAAGAAGTGGTTTATGGAATACTTCACTTGGTTATATTGATTCTCTCTACCAACGGGTTTCCAAGCGATTTGATCAAGTATTAAATAAAAAACTCCCTTATCTTGATATTCATTCTTTTCAACATGATATTTACGATGAAGTGGCCCAAAAAGTTTTAGAGCTAACAGGGCATGCTTTTAAGCGAGTTCTTTATACGAATTCTGGTTCAGAAAATACAGAATTAGCTTTAAAAATCGCTGATTATACCAATAAGAAGGGGGAAAATAATCGTATTCTAGCCTTTAAAGATTCTTATCATGGAACCTTCTTTGGCGGTGTTTCAGTGAGTGGTATTGATCAAGAAATCAATAGTTCTTTCTATCCGAAATATGGAGAAGTAACGTTTATAGACTACCCCAAATCTGCAGAACAAGAAAAAAATGTCCTAGATTATATTGCCAATGTAGCTTCCTTCTATGATGTCATGATGATTGAACCGATTTTGGCTTCGGCAGGTATCTACTTTGCCAGTACAGATTTTTTCAATGCACTTTTAAAACTACTGAGAAAAAATCAAGTTTTGATTGTCTTTGATGAGGTAGCTACTGGATTTTTTAAAACAGGGAAGCCGTTTTATTTCCAACAGTTATCTGAAAAACCGGATATTTTATGCCTCAGTAAAGCTATTAATAACGGCATTACGTCTTTTGGCTGCGTCTGTGTTAATGAAGAAGTTGATGCAAAATTACAGAAAAATCCCAAAACGATGGAGCATTTCTCAACTCAAAATGGGAATCTTTTAGGATTAGAGTCGGCTAATATTGTTCTGGATTACTATCTTAAGTCTAGAGACGTTATAAAAGGCAAAGTCAAAGATATTTCTGATAGTATTTCAAATGTCTTAGATTCACAAAATGTGTTCTACCGTAATCAGGGAATTATGACAGCGATTAGGACAGAAAGCAACCAATCGTTACAGCTAATGAAGTCGTTAGAAAAACTTGGGATACTTACTTATCTTTACGTTAATGAAGAAGAAGAGGGACTGTCTATTATGCCACCGATTAATATTAATCTAAATGTTTTAGAAAAAGCTCTCAAATTGATTTCTAAAAAAATTGAAAGTCAAAATTCTTTTTAA","6.40","-1.91","46917","MKNYALLNGAYDNKTMYDFKPVRADNTYLYDSQNRKYLDLRSGLWNTSLGYIDSLYQRVSKRFDQVLNKKLPYLDIHSFQHDIYDEVAQKVLELTGHAFKRVLYTNSGSENTELALKIADYTNKKGENNRILAFKDSYHGTFFGGVSVSGIDQEINSSFYPKYGEVTFIDYPKSAEQEKNVLDYIANVASFYDVMMIEPILASAGIYFASTDFFNALLKLLRKNQVLIVFDEVATGFFKTGKPFYFQQLSEKPDILCLSKAINNGITSFGCVCVNEEVDAKLQKNPKTMEHFSTQNGNLLGLESANIVLDYYLKSRDVIKGKVKDISDSISNVLDSQNVFYRNQGIMTAIRTESNQSLQLMKSLEKLGILTYLYVNEEEEGLSIMPPININLNVLEKALKLISKKIESQNSF","358722","Consider ECs 2.6.1.19 and 2.6.1.11.","aminotransferase","Cytoplasm","Similarities in gapped BLAST to aminotransferases. Residues 29-407 are 27% similar to gi|15899912, a predicted 4-aminobutyrate aminotransferase from S.solfataricus. Residues 12-402 are 26% similar to gi|15605627, a predicted N-acetylornithine aminotransferase from A.aeolicus (EC 2.6.1.11).SMu0341 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005814
Family

Aminotransferase class-III
PTHR11986	$\"[8-314]T$	Aminotrans_3
PF00202	$\"[20-51]T$ $\"[79-278]T$	Aminotran_3

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[60-315]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[16-408]T$	PyrdxlP-dep_Trfase_major

","BeTs to 9 clades of COG0160COG name: PLP-dependent aminotransferasesFunctional Class:� EThe phylogenetic pattern of COG0160 is AmtKYqvcEBRh---------Number of proteins in this genome belonging to this COG is 2","***** IPB000954 (Aminotransferase class-III pyridoxal-phosphate) with a combined E-value of 1.5e-21. IPB000954A 31-60 IPB000954B 202-241 IPB000954C 250-265 IPB000954D 291-309","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 12:07:41 2002","Fri Jan 25 12:06:39 2002","Fri Jan 25 12:07:41 2002","Fri Jan 25 12:06:39 2002","Fri Jan 25 12:06:39 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0341 is paralogously related (blast p-value < 1e-3) to SMu0608, a predicted N-acetylornithine aminotransferase.","Fri Jan 25 12:07:41 2002","Fri Jan 25 12:06:39 2002","pdb|1DTY|A Chain A, Crystal Structure Of Adenosylmethionine-8-A... 104 3e-023pdb|1QJ3|A Chain A, Crystal Structure Of 7,8-Diaminopelargonic ... 103 3e-023pdb|1GBN|A Chain A, Human Ornithine Aminotransferase Complexed ... 89 7e-019","SMU.376","","Residues 10 to 410 (E-value = 6.3e-21) place SMu0341 in the Aminotran_3 family which is described as Aminotransferase class-III (PF00202)","Fri Jan 25 12:06:39 2002","24378873","","","","","","1","","","SMU.376","" "SMu0342","358920","359159","240","GTGAAAATATTACTTTCAAGAAAGCTACTCTATTTGGAAGTTTTCATAACATTAATATTAGCATATTTAGGTTCAAGTTTTTTAAAGAATCATGAGATATTAACGAATTTTCAAATTTTGTTAGTTAGTACCTTGTCGATTCTTACTGTTTTTACAGCAGGAGTCGCAGTTGCAAATTTTAAAACAAATCAAGAAATTAAAAAGAAGGAGGAAAAAGATGGAAAAAGAGTTGATGTTTGA","10.40","4.22","8921","MKILLSRKLLYLEVFITLILAYLGSSFLKNHEILTNFQILLVSTLSILTVFTAGVAVANFKTNQEIKKKEEKDGKRVDV","359156","","hypothetical protein","Membrane, Cytoplasm","No significant matches in gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1741 (0.001).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[9-27]?$ $\"[37-59]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[26-44]?$	transmembrane_regions

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[11-66]T$	HTH_3
SM00530	$\"[10-66]T$	HTH_XRE
PS50943	$\"[11-66]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[2-70]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[7-116]T$	G3DSA:1.10.260.40

InterPro
IPR001395
Family

Aldo/keto reductase
PD000288	$\"[2-181]T$ $\"[216-281]T$	Q8DVT5_STRMU_Q8DVT5;
PR00069	$\"[71-89]T$ $\"[102-119]T$	ALDKETRDTASE
G3DSA:3.20.20.100	$\"[2-276]T$	no description
PTHR11732	$\"[4-184]T$ $\"[208-252]T$	ALDO/KETO REDUCTASE
PF00248	$\"[1-281]T$	Aldo_ket_red
PS00062	$\"[102-119]T$	ALDOKETO_REDUCTASE_2

noIPR
unintegrated

unintegrated
PTHR11732:SF12	$\"[4-184]T$ $\"[208-252]T$	ALDO/KETO REDUCTASE

","BeTs to 8 clades of COG0667COG name: Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)Functional Class: CThe phylogenetic pattern of COG0667 is ----YqVCEBr-u---o----Number of proteins in this genome belonging to this COG is 1","***** IPB001395 (Aldo/keto reductase family) with a combined E-value of 1.4e-13. IPB001395B 9-28 IPB001395D 78-89 IPB001395E 138-175 IPB001395F 225-270","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:33:04 2002","Thu Oct 10 12:29:03 2002","Fri Jan 25 13:33:04 2002","Tue Oct 8 08:51:25 2002","Fri Jan 25 13:32:36 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0345 is paralogously related (blast p-value < 1e-3) to SMu0761, SMu0620, and SMu0621, all predicted oxidoreductases.","Fri Jan 25 13:34:14 2002","Fri Jan 25 13:32:36 2002","pdb|1FRB| Fr-1 ProteinNADPHZOPOLRESTAT COMPLEX 70 3e-013pdb|1EXB|A Chain A, Structure Of The Cytoplasmic Beta Subunit-T... 67 3e-012pdb|1QRQ|A Chain A, Structure Of A Voltage-Dependent K+ Channel... 67 3e-012","SMU.382c","","Residues 1 to 281 (E-value = 3e-36) place SMu0345 in the Aldo_ket_red family which is described as Aldo/keto reductase family (PF00248)","Fri Jan 25 13:32:36 2002","24378877","","","","","","1","","","SMU.382c","" "SMu0346","363093","362047","1047","ATGAATTCTCCTTACACAAGAAGTCCAAGAACTATCAAACATGCTTTTGTAACTGGTGCCACCGGTCTTTTAGGTAACAATCTTGTTCGCGCTTTACTTAAACAAGGTATTAAAGTCACTGCTCTCGTACGTTCCATGGAAAAAGCTAGGTTACAATTTGGTGATTTGCCTATCCAGTATGTTAAAGGAGACATCCTTAATCCCGAAGCTTTTCGGTCTGCTTTTACCGATTGCGACACTCTTTTTCATACAGCTGCTTTTTTTCGCGATAGTCACAAAGGCGGAAAACATTGGCAAGAACTCTACGATACTAATGTTACAGGAACCACTCATTTATTGAAAGCAGCCTACGAAGAAGGTATTCGTCAAATGATTCATACGTCTTCTATTGCTGTACTTAAAGGGGAACGTCATCAGCTAATTGATGAGACGATGTCACGAGATCCTAGTACCAAATTAGACTATTATCGTAGTAAAATCCTAAGCGAAAATGCTGTGAGCAATTTTCTTAAGGAGTATCCAGATTTATTTCTTTGCTATGTTTTACCAGGTTCTATGTATGGTCCGGGAGATATGGGACCAACTGCTACGGGACAACTAATCTTGGATTACATGCAGCAAAAACTACCCGGGATCATCACCAAAGCTAGCTATAGTGTCGTTGATACCAGAGATGTTGCTGATATTCATATTTTAGCTCTAAAATACGGGCGCAGAAATGAACGCTATTTGGCAGCAGGCCGTCATATGACTATGGAAAGTATTGTCAAAACCTTGGAAGAAATAACAGGCATTCCTGCTCCAAAACGTCATATTCCCATTTTTCTAGTTCAGGCATTAGCCCAATGGAATGAACTTTATCATAAGATTACTGGCAAACCTGTTCTGGTCAGCAAAGAAATTGCAGACATTACAGCTGAAGAATATCTTCGGACATATTTTAGCCATAAAAAAACTGAGCAGGAACTTGGCGGACAATTCAGACCTTTTGAGGAAACCTTGTTAGATACTGTCCGCTGGTATCGCAATCACGGCTATCTGAACTAG","9.60","8.05","39565","MNSPYTRSPRTIKHAFVTGATGLLGNNLVRALLKQGIKVTALVRSMEKARLQFGDLPIQYVKGDILNPEAFRSAFTDCDTLFHTAAFFRDSHKGGKHWQELYDTNVTGTTHLLKAAYEEGIRQMIHTSSIAVLKGERHQLIDETMSRDPSTKLDYYRSKILSENAVSNFLKEYPDLFLCYVLPGSMYGPGDMGPTATGQLILDYMQQKLPGIITKASYSVVDTRDVADIHILALKYGRRNERYLAAGRHMTMESIVKTLEEITGIPAPKRHIPIFLVQALAQWNELYHKITGKPVLVSKEIADITAEEYLRTYFSHKKTEQELGGQFRPFEETLLDTVRWYRNHGYLN","362050","","undetermined reductase or epimerase","Cytoplasm","A variety of matches in gapped BLAST to plant-related sequences. Residues 13-347 are 40% similar to a predicted dihydrokaempferol 4-reductase from Nostoc (gi|17134434). Residues 16-347 are 34% similar to a predicted dihydroflavonol 4-reductase (EC 1.1.1.219) from Synechocystis (gi|16329831).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0664 (1e-04).","

InterPro
IPR001509
Family

NAD-dependent epimerase/dehydratase
PF01370	$\"[15-246]T$	Epimerase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[15-269]T$	G3DSA:3.40.50.720
PTHR10366	$\"[17-273]T$ $\"[292-346]T$	PTHR10366
PTHR10366:SF21	$\"[17-273]T$ $\"[292-346]T$	PTHR10366:SF21
SSF51735	$\"[14-342]T$	SSF51735

","BeTs to 8 clades of COG0451COG name: Nucleoside-diphosphate-sugar epimerasesFunctional Class:� M,GThe phylogenetic pattern of COG0451 is AMTKYQVCEBRHUJ--o----Number of proteins in this genome belonging to this COG is 1","***** IPB001509 (NAD dependent epimerase/dehydratase family) with a combined E-value of 1.3e-07. IPB001509A 15-36 IPB001509B 80-114 IPB001509E 331-341***** IPB002225 (3-Beta hydroxysteroid dehydrogenase/isomerase family) with a combined E-value of 2.6e-06. IPB002225A 12-42 IPB002225B 129-183 IPB002225C 214-256","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:40:30 2002","Fri Jan 25 13:43:49 2002","Fri Jan 25 13:40:30 2002","Fri Jan 25 13:39:42 2002","Fri Jan 25 13:39:42 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0346 is paralogously related (blast p-value < 1e-3) to SMu0810, a predicted UDP-glucose 4-epimerase, to SMu1327, a predicted dTDP-glucose-4,6-dehydratase, to SMu0748, a predicted dTDP-4-keto-L-rhamnose reductase, and to SMu1874, also a predicted UDP-glucose 4-epimerase.","Fri Jan 25 13:43:27 2002","","No significant hits to the NCBI PDB database.","SMU.383c","","Residues 14 to 345 (E-value = 8.4e-12) place SMu0346 in the 3Beta_HSD family which is described as 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073)Residues 15 to 345 (E-value = 3.4e-06) place SMu0346 in the Epimerase family which is described as NAD dependent epimerase/dehydratase family (PF01370)","Fri Jan 25 13:39:42 2002","24378878","","","","","","1","","","SMU.383c","" "SMu0347","363267","363725","459","ATGTCATTGAAAGGGTCTCAATTTAGGTATTTATTTAAAAGTGCTGAAAAACTGGCTATGAAAGAATTAAGTAAATTATTAGAACCTTTGGGAATAACTCCTAATCAAGGAGAAGTCCTTGTTATATTAGGAAGCTGTGCTCCATTATCTTTAAAAGAATTAGGAAATCTACTCATCTGTGAAGAGAAAAGTCCTAGCAGATTGGTACAGTCACTTATTAAGAAAGGTTTAGTTGCTAAAGAAAGATCGACCAGTGACGGGCGCAGCTTCCTGCTTTCTTTAACGGCAGCAGGCCTAAAACTGCTGCCGCAAGTTGAAGCATGCGAAAATAATTTTGATCAAAAATTAGAGAAAGACTACCCAGAAATTGAACGTTTTAGTCAAGCTTTAAGGGAGTATACGAAAGGTAGTTTTTACGAGGAGAAGCTCAAACGTCGTTCTCTCTGGGATAAAGAATGA","9.20","3.86","17184","MSLKGSQFRYLFKSAEKLAMKELSKLLEPLGITPNQGEVLVILGSCAPLSLKELGNLLICEEKSPSRLVQSLIKKGLVAKERSTSDGRSFLLSLTAAGLKLLPQVEACENNFDQKLEKDYPEIERFSQALREYTKGSFYEEKLKRRSLWDKE","363722","","hypothetical protein (possible transcriptional regulator)","Cytoplasm","No significant hits in gapped BLAST, although a very weak similarity to gi|1657237, a hypothetical from Acinetobacter sp.SMu0347 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PF01047	$\"[32-101]T$	MarR
SM00347	$\"[25-125]T$	HTH_MARR
PS50995	$\"[4-135]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[4-124]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[7-133]T$	SSF46785

InterPro
IPR000905
Domain

Peptidase M22, glycoprotease
PF00814	$\"[22-213]T$	Peptidase_M22

","BeTs to 10 clades of COG1214COG name: Inactive homologs of metal-dependent proteases, putative molecular chaperonesFunctional Class: OThe phylogenetic pattern of COG1214 is ------vcebrh--gpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000905 (Glycoprotease, (M22) metallo-protease family) with a combined E-value of 5.9e-08. IPB000905A 3-17 IPB000905C 56-96","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:54:58 2002","Fri Jan 25 13:53:52 2002","Fri Aug 18 16:21:12 2006","Fri Aug 18 16:21:12 2006","Fri Jan 25 13:53:52 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0348 is paralogously related (blast p-value < 1e-3) to SMu0350, also a possible glycoprotein endopeptidase.","Fri Jan 25 13:54:58 2002","","No significant hits to the NCBI PDB database.","SMU.385","","Residues 2 to 207 (E-value = 8.3e-47) place SMu0348 in the Peptidase_M22 family which is described as Glycoprotease family (PF00814)","Fri Jan 25 13:53:52 2002","24378880","","","","","","1","","","SMU.385","725" "SMu0349","364422","364856","435","ATGATGAAAGATGAGAAAAACCAAGAAATAGCTGCTATCCTTTTTGCCATCCTAGAGGATGTTTATCAGGTCTCTCCTTGGAGTCAAAAACAGATTTTAACTGATATGAATCGTCTAGATGTGGATTATTTTTTTGCTTATGATGATAAGGAAATTGTGGGCTTTTTATCTATTCAGCATTTAGTAGGGGAGTTAGAATTGACAAATATAGCTATTAAGAAGGCCTATCAAGGACAGGGGCTAGGTAGTCAACTCTTGGCGATGTTAACAAAGGATGAACTGCCCATCTTTCTAGAAGTACGAGCTTCCAATCAAGCAGCACAAGCTCTTTATCAAAAATTTGGCTTTCGATCTCTTACTACAAGAAAGGATTATTATCATAATCCTAAAGAAGATGCCATTTTGATGAAACGTGAAGGTTTAATAGATTATTAA","4.90","-4.52","16630","MMKDEKNQEIAAILFAILEDVYQVSPWSQKQILTDMNRLDVDYFFAYDDKEIVGFLSIQHLVGELELTNIAIKKAYQGQGLGSQLLAMLTKDELPIFLEVRASNQAAQALYQKFGFRSLTTRKDYYHNPKEDAILMKREGLIDY","364853","For other 'rim' genes see SMu0790 (rimM). ","ribosomal-protein-alanine transferase","Cytoplasm","Similarities in gapped BLAST to ribosomal-protein-alanine acetyltransferases. Residues 8-143 are 52% similar to gi15675692 from S.pyogenes. Residues 5-139 are 47% similar to gi15902174 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1758 (4e-38).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[44-117]T$	Acetyltransf_1
PS51186	$\"[1-141]T$	GNAT

InterPro
IPR006464
Family

Ribosomal-protein-alanine acetyltransferase
TIGR01575	$\"[10-136]T$	rimI

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[12-139]T$	G3DSA:3.40.630.30
PTHR23091	$\"[2-139]T$	PTHR23091
PTHR23091:SF1	$\"[2-139]T$	PTHR23091:SF1
SSF55729	$\"[11-136]T$	SSF55729

","BeTs to 11 clades of COG0456COG name: AcetyltransferasesFunctional Class: RThe phylogenetic pattern of COG0456 is amtkYqvcebrh---------Number of proteins in this genome belonging to this COG is 2","***** IPB000182 (GCN5-related N-acetyltransferase) with a combined E-value of 5.9e-06. IPB000182A 77-86 IPB000182B 110-116","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 11:19:43 2006","Fri Jan 25 13:55:58 2002","Tue Sep 19 11:19:43 2006","Mon Apr 8 09:17:21 2002","Fri Jan 25 13:55:58 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0349 is paralogously related (blast p-value < 1e-3) to SMu1373.","Fri Jan 25 13:59:36 2002","","No significant hits to the NCBI PDB database.","SMU.386","","Residues 44 to 117 (E-value = 2.6e-18) place SMu0349 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Fri Jan 25 13:55:58 2002","24378881","","","Tanaka S, Matsushita Y, Yoshikawa A, Isono K.Cloning and molecular characterization of the gene rimL which encodes an enzyme acetylating ribosomal protein L12 ofEscherichia coli K12.Mol Gen Genet. 1989 Jun;217(2-3):289-93.PMID: 2671655","","Fri Jan 25 14:04:56 2002","1","","","SMU.386","976" "SMu0350","364871","365881","1011","ATGATAGATAGATACATTTTAGCCATCGAATCATCCTGTGATGAAACCAGTGTGGCCATTTTAAAAAATGAAGATCAACTTTTAAGCAATATTATTGCCAGTCAGGTAGAAAGTCATAAGCGTTTTGGTGGTGTGGTACCAGAAGTTGCCAGTCGTCACCATGTTGAAGTCATTACGCTTTGTATTCAGGATGCTTTGCAGGAAGCTGGAATTACTGCAGGTGATTTATCTGCTGTTGCGGTAACTTATGGTCCGGGTCTTGTTGGAGCCCTTTTGGTAGGAATGGCAGCAGCTAAAGCTTTTGCTTGGGCTAATCATTTGCCCTTAATTCCAGTTAATCATATGGCAGGTCATTTAATGGCAGCACAAAGCATTGCCGATTTGCAGTATCCGCTTTTAGCGCTCTTGGTGTCAGGGGGACATACAGAACTTGTCTATGTAGCGGCTCCCGGTGATTATCGTATTGTTGGGGAGACTCGAGACGATGCTGTTGGTGAGGCTTATGACAAAGTCGGGCGCGTCATGGGCCTTACTTATCCTGCAGGCAAAGAAATTGATCAACTAGCTCATCAAGGGCAAGATATCTATGATTTTCCGCGCGCTATGATTAAAGAAGACAATTTGGAATTTTCCTTTTCAGGTCTTAAATCAGCTTTTATTAATCTTCATCATAATGCCCGACAAAAAGGAGAGCAACTCCGCTTAGAAGATTTATGCGCTTCTTTCCAAGCAGCTGTTTTGGATATCTTGATGGTGAAAACAAAAAAGGCTTTGGCAGCTTATCCTGTAAAAACTTTGGTTATTGCTGGAGGTGTGGCAGCTAACCAAGGTCTTCGTGAACGCCTAAAAGAAGACATAAAAGATATTAATGTTGTCATTCCACCACTACGTCTTTGTGGTGATAATGCTGGAATGATTGCTTATGCTGCGGCCGTTGAATATGAAAAGGGCCATTTTGCAGAACTCGATCTAAATGCTAAACCCAGTTTGGCTTTTGAAGGATTAGAATAA","5.20","-11.52","36112","MIDRYILAIESSCDETSVAILKNEDQLLSNIIASQVESHKRFGGVVPEVASRHHVEVITLCIQDALQEAGITAGDLSAVAVTYGPGLVGALLVGMAAAKAFAWANHLPLIPVNHMAGHLMAAQSIADLQYPLLALLVSGGHTELVYVAAPGDYRIVGETRDDAVGEAYDKVGRVMGLTYPAGKEIDQLAHQGQDIYDFPRAMIKEDNLEFSFSGLKSAFINLHHNARQKGEQLRLEDLCASFQAAVLDILMVKTKKALAAYPVKTLVIAGGVAANQGLRERLKEDIKDINVVIPPLRLCGDNAGMIAYAAAVEYEKGHFAELDLNAKPSLAFEGLE","365878","","O-sialoglycoprotein endopeptidase","Cytoplasm, Extracellular","A fragment of this sequence corresponds to the previously sequenced gi4098491, a predicted sialoglycoprotease protein. Residues In addition, residues 31-185 are virtually identical to residues 1-155 of that sequence. In addition, residues 1-336 are 78% similar to gi15902175, a predicted metalloendoprotease, from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1757 (1e-152).","

InterPro
IPR000905
Domain

Peptidase M22, glycoprotease
PD002367	$\"[236-283]T$	Peptidase_M22
PR00789	$\"[7-20]T$ $\"[79-99]T$ $\"[100-119]T$ $\"[133-145]T$ $\"[156-177]T$ $\"[266-275]T$	OSIALOPTASE
PF00814	$\"[26-308]T$	Peptidase_M22
TIGR00329	$\"[7-307]T$	gcp

InterPro
IPR009180
Family

Peptidase M22, O-sialoglycoprotein endopeptidase
PIRSF004537	$\"[4-335]T$	Osialglc_pptds
PTHR11735	$\"[100-328]T$	Pept_M22_Osialgl

noIPR
unintegrated

unintegrated
SSF53067	$\"[3-317]T$	SSF53067

","BeTs to 17 clades of COG0533COG name: Metal-dependent proteases with possible chaperone activityFunctional Class: OThe phylogenetic pattern of COG0533 is amtkYQvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000905 (Glycoprotease, (M22) metallo-protease family) with a combined E-value of 7.1e-84. IPB000905A 6-20 IPB000905B 43-54 IPB000905C 75-115 IPB000905D 133-145 IPB000905E 156-183 IPB000905F 208-219 IPB000905G 270-279 IPB000905H 298-307","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 14:11:08 2002","Tue Sep 19 11:13:27 2006","Tue Sep 19 11:13:27 2006","Tue Oct 8 08:53:58 2002","Fri Jan 25 14:07:13 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0350 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome (however, see SMu0348).","Fri Jan 25 14:17:13 2002","","No significant hits to the NCBI PDB database.","SMU.387","","Residues 5 to 281 (E-value = 1.5e-118) place SMu0350 in the Peptidase_M22 family which is described as Glycoprotease family (PF00814)","Fri Jan 25 14:07:13 2002","24378882","","","","Tue Sep 19 11:13:27 2006","","1","","","SMU.387","470" "SMu0351","365960","366658","699","ATGCAAGAAAAAGGCTTCAAGGAAGGAGTTAAGGCATCTCTGCCAACAGCCTTAGGTTATGTTAGTATTGGACTTGCCTGTGGAGTTGTAGGAGCAAATTCAGGTTTAACGCCTTTTCAGATGGGCTTAATGAGTCTGTTAGTCTATGCTGGCAGCGCTCAATTTGTTATGTGCGCCATGTTTGTAGCTGGTGCAGATTTATTTTCAATTGTCATGACTGTTTTTTTAATTAATCTTCGAAATTTCTTGATGAGTTTGCATGCGACAACGATCTTTACTAAATCCAGTCTTTGGCAAACTATCTGTATCGGAACACTCATTACAGATGAAAGTTATGGTGTTCTCTTGAATGAACATGTTCATCATAAAAATATTAGTACAGCTTGGATGCATGGCAATAATATTACGGGGTATATTGCTTGGTTATTTGCAGTTATTTTGGGAACTGCCTTGGGTTCTGTTATTCCTAATCCTGAGACGCTTGGTTTAGATTTTGCGCTTATTGCCATGTTTGTTTCTATCTTTGAATCTCAATTAGCCGCTATGATGCAGTTCGTAAAGCTTAAAAAGATAGGACTTATTTTATTGGCTGTAACCTTATCTTATTTTTTATTAGTTATTGTGATATCTGAATCTTTGGCTGTTTTACTTTCAACATTAATAGGTTGTTTTGCGGGGGTGCTTCTTGATGTCAGATAA","7.00","0.00","24923","MQEKGFKEGVKASLPTALGYVSIGLACGVVGANSGLTPFQMGLMSLLVYAGSAQFVMCAMFVAGADLFSIVMTVFLINLRNFLMSLHATTIFTKSSLWQTICIGTLITDESYGVLLNEHVHHKNISTAWMHGNNITGYIAWLFAVILGTALGSVIPNPETLGLDFALIAMFVSIFESQLAAMMQFVKLKKIGLILLAVTLSYFLLVIVISESLAVLLSTLIGCFAGVLLDVR","366655","","possible branched-chain amino acid permease","Membrane, Cytoplasm","Matches in gapped BLAST to hypotheticals and possible transport proteins. Residues 14-230 are 55% similar to gi15900084 from S.pneumoniae. Residues 3-230 are 44% similar to gi16803482 from L.monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2051 (4e-76).","

InterPro
IPR011606
Family

AzlC-like
PF03591	$\"[14-156]T$	AzlC

noIPR
unintegrated

unintegrated
PS51257	$\"[1-27]T$	PROKAR_LIPOPROTEIN

","BeTs to 4 clades of COG1296COG name: Predicted branched-chain amino acid permease (azaleucine resistance)Functional Class: EThe phylogenetic pattern of COG1296 is a-------eb-huj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 08:54:27 2002","Mon Aug 21 14:08:19 2006","Mon Aug 21 14:08:19 2006","Tue Oct 8 08:54:27 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0351 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 08:54:27 2002","","No significant hits to the NCBI PDB database.","SMU.388","","Residues 14 to 174 (E-value = 2.9e-63) place SMu0351 in the AzlC family which is described as AzlC protein (PF03591)","Fri Jan 25 14:21:01 2002","24378883","","","","","","1","","","SMU.388","735" "SMu0352","366648","366971","324","ATGTCAGATAATTTTATTTTACTTGCCATAGGACTTAGTGCCTTAGTAACATGGATTCCACGGATTGCTCCCTTTATTTTAACTAAATATAAAGCCTTGCCGAATTTTATTATTCGTTTTCTCAATTATCTGCCAATTACGATTATCTTTGCTTTAACATTATCTAGCGTTGTCATTGAAAGAACAGGGCATTTACCAAGTATCAAATGGTTGGAATTGTTGGCGGTGTTGCCGACTTTCTGGGTGGCTGCCAAGACAAAGAATATCCTCTTAGCAGTGGTGGCAGGAGTTCTTATAATGGCTTTTCTAAGATTTGTTTTTTGA","11.20","6.22","12011","MSDNFILLAIGLSALVTWIPRIAPFILTKYKALPNFIIRFLNYLPITIIFALTLSSVVIERTGHLPSIKWLELLAVLPTFWVAAKTKNILLAVVAGVLIMAFLRFVF","366968","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypotheticals. Residues 2-107 are 44% similar to gi|15673594 from L.lactis. Residues 4-106 are 42% similar to gi|16800549 from L.inocua. Residues 1-69 are 59% similar to gi|15900085 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2050 (3e-27).","

InterPro
IPR008407
Family

Branched-chain amino acid transport
PF05437	$\"[6-105]T$	AzlD

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 14:44:15 2002","Fri Jan 25 14:44:15 2002","Fri Jan 25 14:44:15 2002","Fri Jan 25 14:44:15 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0352 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 14:44:15 2002","","No significant hits to the NCBI PDB database.","SMU.389","","Residues 1 to 107 (E-value = 2.2e-12) place SMu0352 in the DUF931 family which is described as Domain of unknown function (DUF931) (PF06063)","Fri Jan 25 14:44:15 2002","24378884","","","","","","1","","","SMU.389","982" "SMu0353","366854","367012","159","ATGGTTGGAATTGTTGGCGGTGTTGCCGACTTTCTGGGTGGCTGCCAAGACAAAGAATATCCTCTTAGCAGTGGTGGCAGGAGTTCTTATAATGGCTTTTCTAAGATTTGTTTTTTGAAGATAGAGCACTTTGGTTCTTATTCCTACCAAGGAAGGTAA","8.10","1.12","5597","MVGIVGGVADFLGGCQDKEYPLSSGGRSSYNGFSKICFLKIEHFGSYSYQGR","367009","","hypothetical protein","Extracellular","No significant hits in gapped BLAST.SMu0353 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 14:45:25 2002","Fri Jan 25 14:45:25 2002","Fri Jan 25 14:45:25 2002","Fri Jan 25 14:45:25 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0353 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 14:45:25 2002","","No significant hits to the NCBI PDB database.","SMU.390","","No significant hits to the Pfam 11.0 database","Fri Jan 25 14:45:25 2002","24378885","","","","","","1","","","SMU.390","" "SMu0354","367558","367067","492","ATGATGATGTCAGTAACCTTCCCTCCAGGTCGTCCTTTATCAAATTTTCTTTTGGAGGGGACTATCATGAAATTGACAGTCTATTTTGATGGCACATTTTGGTTTGCTTTGGTTGAACATGTCAACCGTAAAGGACAATATAAAGTCTTTCGTTATCCATTTGGCAAAGAGCCTAAGGATTCTGATATTTGGAACTTTATTGCTAAAAAGCTGCCCAGTTTGATTAAGAAATACGATCATATCAAAACTAGTTCTCATGCTGATAGTATACCGCAGCCTAAGAAGATGAATCCCAAGCGTATGCAAAGGGTTCTTAATAAATCCAAAAAACAGTCTGCGGTTTCTACTAAGGCTCAGGCAGAGATGCAAAAGCTTCATGAGGCTTTAAAAAAAGAGAAAAAATCTCAAAGTAAAGAAAAACGGCAAGCTCTAAAGCAGTACAAATATCAACTGAAGCAGGAAAAACGCCATCAAAAAAGGCAAGGACACTAA","11.10","25.43","19251","MMMSVTFPPGRPLSNFLLEGTIMKLTVYFDGTFWFALVEHVNRKGQYKVFRYPFGKEPKDSDIWNFIAKKLPSLIKKYDHIKTSSHADSIPQPKKMNPKRMQRVLNKSKKQSAVSTKAQAEMQKLHEALKKEKKSQSKEKRQALKQYKYQLKQEKRHQKRQGH","367070","","conserved hypothetical protein","Periplasm, Membrane, Extracellular","Two weak matches in gapped BLAST to B.subtilis and C.acetobutylicum sequences. Residues 3-128 are 39% similar to yjdF (gi16078268). Residues 23-119 are 35% similar to gi15894851, a yjdF ortholog.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0090 (7e-28).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 09:08:19 2006","Thu Sep 28 09:08:19 2006","Thu Sep 28 09:08:19 2006","Fri Jan 25 14:49:27 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0354 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Sep 28 09:08:19 2006","","No significant hits to the NCBI PDB database.","SMU.391c","","No significant hits to the Pfam 11.0 database","Fri Jan 25 14:49:27 2002","24378886","","","","","","1","","","SMU.391c","" "SMu0355","368828","367656","1173","ATGACACATTTTGATACAATCGTTATCGGCGGCGGGCCTGCGGGTATGATGGCCTGCATTTCTGCTGGGTTTTATGGTAAGAAAGCCCTTCTTCTAGAAAAGAACAAACGGCTTGGTAAAAAGCTGGCTGGTACTGGTGGAGGACGCTGTAATGTTACCAATAACGGCACTTTAGAGGATTTACTAGCCGGTATTCCCGGCAATGGACGTTTTCTCCATAGTGTTTTTTCTCAATTTGATAATCATGATATTATGTCTTTTTTTGAAGATAATGGCGTCGCCTTAAAGGTTGAAGATCACGGCAGAGTCTTTCCCAAAACAAACAAATCATGCACTATTATTGATTGTCTGGAAAGAAAAATCAAAGAACTTGGTGGTTTAATCAAGACACAGTGCGAAATTGTTTCCGTCAAAAAAGAGGATGGACAGTTTATTGTTAAATCAGCTGATGAAGCTTTCACCTGCCAGCAGTTGATTATTACAACTGGCGGAAAATCTTATCCTTCCACCGGTTCAACTGGCTTTGGTTATGCTATTGCTAAACATTTCAAATTGAAAGTGACCCATCTTGAAGCCGCTGAGAGTCCTCTACTGACTGATTTTCCTCACAAAGCGCTACAGGGGATTTCACTTGATGATGTGACATTGACATGTGGTAAACATCAGATCAATCATGATCTGCTTTTTACGCATTTTGGTCTATCTGGTCCTGCAGCACTGCGCTTATCCACTTTTATTCAGGGAGGAGAAACAGCCTATTTAGATTTATTACCACAGCTTACTAAAGAAGCATTGCTGAAAAAAATTGAAACAACTCGGGAAAAATCGTTGAAAAATGCCTTGAAGACATTCTTGCCTGAACGTCTAGCAGCATTTCTATCAGAAGGTTATGACCACAAGGTCAAACAGCTTTCCAAAAAAGATTTGGAAAAAATTCTCCATAAAATCAAAGCTTTACCGATTCCAATTACTGGTAAAATGTCTCTAGCTAAGTCTTTTGTGACCAAGGGTGGTATTGACTTAAAGGAAATCAATCCTAAAACCTTGGAAAGCAAAACTATTTCTGGTCTACATTTTGCTGGTGAAGTGCTTGATATTAACGCCCATACTGGCGGCTTCAATATCACAGCAGCCCTTTGTACTGGCTGGGTTGCTGGCAGTTTACACTACTAA","9.20","12.24","42243","MTHFDTIVIGGGPAGMMACISAGFYGKKALLLEKNKRLGKKLAGTGGGRCNVTNNGTLEDLLAGIPGNGRFLHSVFSQFDNHDIMSFFEDNGVALKVEDHGRVFPKTNKSCTIIDCLERKIKELGGLIKTQCEIVSVKKEDGQFIVKSADEAFTCQQLIITTGGKSYPSTGSTGFGYAIAKHFKLKVTHLEAAESPLLTDFPHKALQGISLDDVTLTCGKHQINHDLLFTHFGLSGPAALRLSTFIQGGETAYLDLLPQLTKEALLKKIETTREKSLKNALKTFLPERLAAFLSEGYDHKVKQLSKKDLEKILHKIKALPIPITGKMSLAKSFVTKGGIDLKEINPKTLESKTISGLHFAGEVLDINAHTGGFNITAALCTGWVAGSLHY","367659","","conserved hypothetical protein, HI0933-like","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-390 are 75% similar to gi15902695 from S.pneumoniae. Residues 1-386 are 73% similar to gi15675685 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1752 (1e-170).","

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[5-27]T$ $\"[158-167]T$	PNDRDTASEI

InterPro
IPR004792
Family

HI0933-like protein
PD018041	$\"[309-386]T$	HI0933_like
PF03486	$\"[4-388]T$	HI0933_like
TIGR00275	$\"[7-386]T$	HI0933_like

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[5-27]T$ $\"[158-167]T$	FADPNR

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[1-163]T$	G3DSA:3.50.50.60
PTHR10668	$\"[1-39]T$	PTHR10668
PTHR10668:SF2	$\"[1-39]T$	PTHR10668:SF2
SSF51905	$\"[1-386]T$	SSF51905

","BeTs to 3 clades of COG2081COG name: Predicted flavoproteins, YhiN familyFunctional Class: RThe phylogenetic pattern of COG2081 is -------ceb-h---------Number of proteins in this genome belonging to this COG is 1","***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 5.7e-07. PR00368A 5-27 PR00368B 158-167","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 14:53:27 2002","Tue Sep 19 11:05:16 2006","Tue Sep 19 11:05:16 2006","Tue Sep 19 11:05:16 2006","Fri Jan 25 14:52:37 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0355 is paralogously related (blast p-value < 1e-3) to SMu0420, a predicted thioredoxin reductase.","Fri Jan 25 14:53:27 2002","","No significant hits to the NCBI PDB database.","SMU.392c","","Residues 48 to 383 (E-value = 7.7e-178) place SMu0355 in the HI0933_like family which is described as HI0933-like protein (PF03486)","Fri Jan 25 14:52:37 2002","24378887","","","","","","1","","","SMU.392c","469" "SMu0356","368963","369478","516","ATGGCAATTGAAAAGACAGTCAGCGAATTGGCTGAGATTTTAGGAGTGAGCCGACAAGCGGTTAATAATCGTGTCAAATCTTTTCCTGAAGAGTATGTTGAAAAGAATGATAAAGGTGTTACTGTTGTTAATCGTGCTGGTCTGATCAAATTAGAAGAAATTTATAAGAAAACTATTTTTGAAGATGAACCTGTCAGTGAAGAAGCAAAACAACGTGAATTTCTAGAAATTTTGATTGATGAGAAGAATACAGAAATCACTCGTCTTTATGATCAGCTCAAAGCAAAAGACAGTCAGCTAGAATCAAAGGACGAACAGCTGCGTATCAAAGATGTTCAAATTGCTGAAAAAGATAAGCAAATTGATCAACAACAGCAATTAACATTGACGGCTATGCAAGACAAAGAACAATTGAAGCTGGAACTTGATGAAGCCAAAGCAGAAGTTGAAGAAATTCAAAGCCAGCAAGAAGGCATTAAAAAAGGCTTTTTTGCACGTTTATTTGGTGGAAAATAA","4.70","-8.98","19731","MAIEKTVSELAEILGVSRQAVNNRVKSFPEEYVEKNDKGVTVVNRAGLIKLEEIYKKTIFEDEPVSEEAKQREFLEILIDEKNTEITRLYDQLKAKDSQLESKDEQLRIKDVQIAEKDKQIDQQQQLTLTAMQDKEQLKLELDEAKAEVEEIQSQQEGIKKGFFARLFGGK","369475","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-168 are 77% similar to gi|15675684 from S.pyogenes. Residues 1-170 are 75% similar to gi|15900867 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1751 (1e-69).","

InterPro
IPR007489
Domain

Protein of unknown function DUF536
PF04394	$\"[100-147]T$	DUF536

noIPR
unintegrated

unintegrated
SSF46785	$\"[6-52]T$	SSF46785

","BeTs to 5 clades of COG1196COG name: Chromosome segregation ATPasesFunctional Class:� DThe phylogenetic pattern of COG1196 is am-kYqvc-br---gpol---Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 14:56:10 2002","Fri Jan 25 14:56:10 2002","Fri Jan 25 14:56:10 2002","Fri Jan 25 14:56:10 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0356 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 14:56:10 2002","","No significant hits to the NCBI PDB database.","SMU.393","","Residues 100 to 147 (E-value = 6.8e-12) place SMu0356 in the DUF536 family which is described as Protein of unknown function, DUF536 (PF04394)","Fri Jan 25 14:56:10 2002","24378888","","","","","","1","","","SMU.393","724" "SMu0357","369897","369598","300","ATGATGAATATGCAAAATATGATGAAACAAGCGCAAAAATTGCAAAAGCAAATGGAAAAAAAGCAGTCTGAATTGGCTAGCATGACTTTTGTTGGTAAATCTGCACAAGATCTTGTTGTCGCAACCTTTACAGGTAATAAGAAATTAGTTTCTATTGACTTTAAAGAAGCTGTTGTTGATCCCGATGATAGGGAAACTCTGCAAGATATGACTGTTCAGGCTATTAATGATGCACTTGGTCAAATTGAAGATGCTACGCAAAAGACAATGGGGGCATTTGCAGGTAAATTACCATTCTAA","5.20","-1.01","10989","MMNMQNMMKQAQKLQKQMEKKQSELASMTFVGKSAQDLVVATFTGNKKLVSIDFKEAVVDPDDRETLQDMTVQAINDALGQIEDATQKTMGAFAGKLPF","369601","","conserved hypothetical protein","Cytoplasm, Periplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 23-99 are 77% similar to gi|15675681 from S.pyogenes and 74% similar to gi|15903054| from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1747 (2e-29).","

InterPro
IPR004401
Family

Conserved hypothetical protein 103
PF02575	$\"[8-99]T$	DUF149
TIGR00103	$\"[1-99]T$	CHP103

noIPR
unintegrated

unintegrated
G3DSA:3.30.1310.10	$\"[1-99]T$	G3DSA:3.30.1310.10
PIRSF004555	$\"[1-99]T$	UCP004555
SSF82607	$\"[4-96]T$	SSF82607

","BeTs to 9 clades of COG0718COG name: Uncharacterized BCR, YbaB familyFunctional Class:� SThe phylogenetic pattern of COG0718 is ------vcebrhujgpo-inxNumber of proteins in this genome belonging to this COG is 1","***** IPB003727 (DUF149) with a combined E-value of 3.6e-11. IPB003727 16-63","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 14:58:57 2002","Fri Jan 25 14:58:57 2002","Fri Jan 25 14:58:57 2002","Fri Jan 25 14:58:57 2002","Fri Jan 25 14:58:57 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0357 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 14:58:57 2002","","No significant hits to the NCBI PDB database.","SMU.394c","","Residues 8 to 99 (E-value = 3.8e-36) place SMu0357 in the DUF149 family which is described as Uncharacterised BCR, YbaB family COG0718 (PF02575)","Fri Jan 25 14:58:57 2002","24378889","","","","","","1","","","SMU.394c","975" "SMu0358","372432","370156","2277","ATGAAATATAATCAATACAGTTATATCGGTACTTCAGTCTCACAGGCTGAAAAAGAGCTAAAAGAACTTGGTTTTCAAATCAGCAGTCAAAAAACCAATAAAGCAAACTTAGCGACCTTTGTTAGTCAAGTTTACTTTCACAATCCTGATAAAGATGATGTCTTCAAAAGTATAATTGCTGATAGTCAGACTGATTTAGCAACTTTTTTGCATTCTGACCGAGAATTAACAGAAGAGATTTTTTATACTATAGCCTTGCAACTCTTGGAATTTACGCCTTATATTGACTTTGACGAAGCAAAAACTTTCATTAAACACAGTCATTTTCCTATCATCTTTCAACCAAAGCACTTCTTATTGAATTTTTATCAATTGCTGGGGACGCGTACTAAAAATGGAATGACTTTGATTGATAAGTTGGTCAGTCAAGGCTTTTTGCCAGCCGATAACCATTATCGTTATTTTAATGGCAAGAGTCTAGCAACCTTTGATACGAATGCTCTCATCCGTGAAATTGTTTATGTCGAAGCTCCCCTTGATACCGATAAAGATGGACAACTGGATCTCATTAAGGTCAATATTATTCGCCCCCAAACAAAGGCAAAACTACCAGTCGTCATGACGGCCAGTCCCTATCACCAAGGAACAAATGATAAAGGAGCCGATAAAAAATTGCATCAAATGGAAGGTGAATTGACTGTTAAAAAAGCTGCTACTATTACCGTCACTGATTCCCATTTTCAGGCTCTGCAAGTTCCTTCTTCCAATTTGCCAATTAGTCCTGCACAAGAAAGTTTTTCTTACATTGACAGCTATACCCTCAATGATTACTTTCTAGCTCGCGGTTTTGCTAACATTTATGTATCAGGTGTTGGCACCAAAGATTCCGATGGCTTTATGACGAGCGGTGATTATGCTCAAATCGAATCCTTTAAGGCCGTTATTGATTGGTTAAATGGCAGAACCACTGCCTATACGAGTCATAAGCGTGATAAAAGGGTTATGGCTGACTGGACTAATGGTTTGGTAGCCACAACAGGAAAATCCTATTTAGGAACCATGTCAACAGGACTAGCAACGACTGGTATTAAAGAACTTAAGGTCATTATTGCGGAATCTGCTATTTCTTCTTGGTATGATTATTATCGTGAAAATGGTCTGGTGTGCAGTCCCGGTGGCTATCCGGGAGAGGATATAGATGTTCTGACGGAATTGACCTATTCTCGAAATTTAGCAGCTGGCGATTATCTAAGAAATAATGCGCAATATCAAAAAATGCTAGCAGAACAAGTTAAACAAATTGATCGTACCAGTGGCGATTACAATCAATTTTGGCAGGACCGCAATTATCTTCCTCATGCTCATAAGATCAAAGCACATGTTGTCTATACTCATGGTCTGCAAGACTGGAATGTCAAGCCAAATCAAGTCTACTACATTTTTAATGCTCTGCCAGAGGAGATCCAAAAGCATATTTTTCTTCATCAAGGGCAACATGTCTATATGCATAACTGGCAATCCATTGATTTTCGTGAAAGCATGAATGCCCTTTTAAGTGAAGAACTATTAGGTCTACAGAATCATTTTCAGTTACCAACTATTATTTGGCAGGATAATTCACAAGTACAAACTTGGAAAAAACTTAACAATTTCGGCTCTCATCAGACACGTCAATTTTCTCTTGGGCAAGAGAAAAAAATCATTGATAATCACTATCCTTCTTCTGATTTTAAGCTTTATAGTGATGACTATCATGCTTTTAAACACGATCTTTTTCTCAAGAAAGCTAACGAAATTGCCATTGACTTACCCATCCAAGAAGATATGCTAGTTAACGGACAGATCAAACTCAATCTGACACTTAAATCCAGCAGTAATAAAGGACTGCTCTCTGCCCAAGTTCTTGATTATGGTCAAAAAAAGCGTTTCTCTGATTTACCAACAATCCTTGAACACAATAGCATTGACAACGGACAAAATTTCTCCCGTGAAGCTTTACGAGAACTACCCTTTAAAAAAGCACCTTATCGCATCATCACAAAAGGCGTCCTTAATTTACAAAATCGCACAGATCTCTTAACGATTGAAGATATCTTTCCCAACAAATGGATGACCATTACTTTTAATCTCCAAGCAAGTCTTTATCAGCTACAAAAAGGAGACAGTCTCAGAATCGTCCTCTATACTACAGACTTTGAACAAACCGTTCGTGATAACAGCAACTATATTCTGGTAGTTGATTTAGCAAAATCAACTATCGAAATCCCCATTGCTTAA","6.70","-3.22","86734","MKYNQYSYIGTSVSQAEKELKELGFQISSQKTNKANLATFVSQVYFHNPDKDDVFKSIIADSQTDLATFLHSDRELTEEIFYTIALQLLEFTPYIDFDEAKTFIKHSHFPIIFQPKHFLLNFYQLLGTRTKNGMTLIDKLVSQGFLPADNHYRYFNGKSLATFDTNALIREIVYVEAPLDTDKDGQLDLIKVNIIRPQTKAKLPVVMTASPYHQGTNDKGADKKLHQMEGELTVKKAATITVTDSHFQALQVPSSNLPISPAQESFSYIDSYTLNDYFLARGFANIYVSGVGTKDSDGFMTSGDYAQIESFKAVIDWLNGRTTAYTSHKRDKRVMADWTNGLVATTGKSYLGTMSTGLATTGIKELKVIIAESAISSWYDYYRENGLVCSPGGYPGEDIDVLTELTYSRNLAAGDYLRNNAQYQKMLAEQVKQIDRTSGDYNQFWQDRNYLPHAHKIKAHVVYTHGLQDWNVKPNQVYYIFNALPEEIQKHIFLHQGQHVYMHNWQSIDFRESMNALLSEELLGLQNHFQLPTIIWQDNSQVQTWKKLNNFGSHQTRQFSLGQEKKIIDNHYPSSDFKLYSDDYHAFKHDLFLKKANEIAIDLPIQEDMLVNGQIKLNLTLKSSSNKGLLSAQVLDYGQKKRFSDLPTILEHNSIDNGQNFSREALRELPFKKAPYRIITKGVLNLQNRTDLLTIEDIFPNKWMTITFNLQASLYQLQKGDSLRIVLYTTDFEQTVRDNSNYILVVDLAKSTIEIPIA","370159","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). ","X-prolyl dipeptidyl-peptidase","Cytoplasm, Extracellular","This sequence partially corresponds to the previously sequenced gi4098499 in GenBank, a predicted X-Prolyl Dipeptdidyl Aminopeptidase. See also orthologs in gapped BLAST to X-Prolyl Dipeptdidyl Aminopeptidase, e.g. residues 1-758 are 64% similar to gi15675679 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1736 (0.0).","

InterPro
IPR000383
Domain

Peptidase S15
PF02129	$\"[184-501]T$	Peptidase_S15

InterPro
IPR008252
Domain

Peptidase S15, Lactococcus X-Pro dipeptidyl-peptidase
PR00923	$\"[154-166]T$ $\"[170-180]T$ $\"[188-197]T$ $\"[202-218]T$ $\"[372-388]T$ $\"[507-523]T$ $\"[722-737]T$	LACTOPTASE

InterPro
IPR008979
Domain

Galactose-binding like
SSF49785	$\"[549-757]T$	Gal_bind_like

InterPro
IPR013736
Domain

Peptidase S15/CocE/NonD, C-terminal
PF08530	$\"[515-754]T$	PepX_C

InterPro
IPR015251
Domain

X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal
PF09168	$\"[1-145]T$	PepX_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[190-548]T$	G3DSA:3.40.50.1820
SSF53474	$\"[148-551]T$	SSF53474
SSF81761	$\"[1-147]T$	SSF81761

","No hits to the COGs database.","***** PR00923 (Lactococcus X-Pro dipeptidyl-peptidase (S15) family signature) with a combined E-value of 8.3e-53. PR00923A 154-166 PR00923B 170-180 PR00923C 188-197 PR00923D 202-218 PR00923E 372-388 PR00923F 507-523 PR00923G 722-737","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 16 08:53:49 2006","Wed Aug 16 08:53:49 2006","Wed Aug 16 08:51:11 2006","Fri Jan 25 15:01:15 2002","Fri Jan 25 15:01:15 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0358 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 15:03:22 2002","","No significant hits to the NCBI PDB database.","SMU.395c","","Residues 184 to 754 (E-value = 2e-102) place SMu0358 in the Peptidase_S15 family which is described as X-Pro dipeptidyl-peptidase (S15 family) (PF02129)","Fri Jan 25 15:01:15 2002","","","","Goldstein JM, Banbula A, Kordula T, Mayo JA, Travis J.Novel extracellular x-prolyl dipeptidyl-peptidase (DPP) from Streptococcus gordonii FSS2: an emerging subfamily of viridansStreptococcal x-prolyl DPPs.Infect Immun. 2001 Sep;69(9):5494-501.PMID: 11500422Varmanen P, Savijoki K, Avall S, Palva A, Tynkkynen S.X-prolyl dipeptidyl aminopeptidase gene (pepX) is part of the glnRA operon in Lactobacillus rhamnosus.J Bacteriol. 2000 Jan;182(1):146-54.PMID: 10613874Tsakalidou E, Anastasiou R, Papadimitriou K, Manolopoulou E, Kalantzopoulos G.Purification and characterisation of an intracellular X-prolyl-dipeptidyl aminopeptidase from Streptococcus thermophilus ACA-DC 4.J Biotechnol. 1997 Jan 3;59(3):203-11.PMID: 9519481Chich JF, Rigolet P, Nardi M, Gripon JC, Ribadeau-Dumas B, Brunie S.Purification, crystallization, and preliminary X-ray analysis of PepX, an X-prolyl dipeptidyl aminopeptidase from Lactococcuslactis.Proteins. 1995 Oct;23(2):278-81.PMID: 8592708","Wed Aug 16 08:51:11 2006","Fri Jan 25 15:11:26 2002","1","","","SMU.395c","179" "SMu0359","372547","373416","870","ATGGATGTTACGTGGACTGTGAAATATATCACAGAATTTATTGGTACTGCTCTACTCGTTATTTTGGGGAATGGTGCCGTTGCAAATGTAGAATTGAAAGGAACAAAAGGTTACAAAAGTGGCTGGGTTATTATCACCTTAGGTTATGGTTTTGGTGTGATGCTGCCCGCTTTGATGTTTGGTAATGTATCTGGTAACCATATTAATCCTGCTTTTACGCTTGGCCTTGCAATATCGGATCTTTTCCCTTGGAAACAAGTACTTCCTTACATTCTTGCACAAATGCTGGGAGCTATCTTTGGTCAGTTAATTATTGTGGCAACTCATGCTCCTTATTACAGGCAAACTGAAAGTTCTGATGGTATTTTGGGAACATTCTCTACTATCTCAGCTGTGGATGATGGTACGGATGCAAGTAAGAAAGCTTCACTTATCAATGGTTTTTTAAATGAGTTTGCTGGTTCATTTGTGCTTTTCTTTGGTGCACTTGCTCTTACGAAAAACTACTTTGGCGGTGAAATTGTTCAGCAATTAAACACCATGGGAACTGATGTAACATCTTCTACTTTTAAATTCTCTCAAGTTGGTCTGACAGTGGGTGCCAATGTTAATTCTGGTTTGGCGATAGCTCACCTTGGTTTAGGTTTCCTTGTTATGGCACTGGTAGCATCTTTAGGAGGTCCTACTGGACCTGCCCTTAATCCTGCACGTGACTTAGGTCCGCGTCTTCTTCACCATTTCTTGCCAGAATCAGTACTTGGTAAATCTAAGGGTAACTCAAAGTGGTGGTATTCTTGGGTTCCAGTCATTGCACCAATCCTTGCTGGAATAGCAGGCGTTGCCTTGTTCAAATATTTATATATGAAGTAA","9.80","4.19","30676","MDVTWTVKYITEFIGTALLVILGNGAVANVELKGTKGYKSGWVIITLGYGFGVMLPALMFGNVSGNHINPAFTLGLAISDLFPWKQVLPYILAQMLGAIFGQLIIVATHAPYYRQTESSDGILGTFSTISAVDDGTDASKKASLINGFLNEFAGSFVLFFGALALTKNYFGGEIVQQLNTMGTDVTSSTFKFSQVGLTVGANVNSGLAIAHLGLGFLVMALVASLGGPTGPALNPARDLGPRLLHHFLPESVLGKSKGNSKWWYSWVPVIAPILAGIAGVALFKYLYMK","373413","For other 'glp' genes see SMu0661 (glpQ).","glycerol uptake facilitator protein","Membrane, Extracellular","Similarities in gapped BLAST to glycerol uptake facilitator proteins. Residues 1-288 are 67% similar to gi15901339 from S.pneumoniae. Residues 1-289 are 68% similar to gi15675676 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1732 (1e-114).","

InterPro
IPR000425
Family

Major intrinsic protein
PD000295	$\"[8-286]T$	MIP
PR00783	$\"[7-26]T$ $\"[49-73]T$ $\"[86-105]T$ $\"[150-168]T$	MINTRINSICP
G3DSA:1.20.1080.10	$\"[3-287]T$	MIP
PTHR19139	$\"[9-118]T$ $\"[135-187]T$ $\"[209-268]T$	MIP
PF00230	$\"[1-283]T$	MIP
PS00221	$\"[67-75]?$	MIP
SSF81338	$\"[4-289]T$	MIP

InterPro
IPR012269
Family

Aquaporin
PIRSF002276	$\"[6-286]T$	AQP

noIPR
unintegrated

unintegrated
PTHR19139:SF10	$\"[9-118]T$ $\"[135-187]T$ $\"[209-268]T$	PTHR19139:SF10

","BeTs to 9 clades of COG0580COG name: Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)Functional Class: GThe phylogenetic pattern of COG0580 is a-t-Y-vcEb-H--gpo----Number of proteins in this genome belonging to this COG is 1","***** IPB000425 (MIP family) with a combined E-value of 7.3e-42. IPB000425A 11-26 IPB000425B 45-97 IPB000425C 229-243 IPB000425D 265-283 IPB000425B 210-262 IPB000425C 64-78","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 12:49:17 2006","Fri Jan 25 15:13:00 2002","Wed Sep 27 12:49:17 2006","Thu Apr 4 14:05:06 2002","Fri Jan 25 15:13:00 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0359 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 15:15:53 2002","Wed Sep 27 12:49:17 2006","pdb1FX8A Chain A, Crystal Structure Of The E. Coli Glycerol F... 86 6e-018","SMU.396","","Residues 1 to 283 (E-value = 6.3e-82) place SMu0359 in the MIP family which is described as Major intrinsic protein (PF00230)","Fri Jan 25 15:13:00 2002","24378891","","","Beijer L, Nilsson RP, Holmberg C, Rutberg L.The glpP and glpF genes of the glycerol regulon in Bacillus subtilis.J Gen Microbiol. 1993 Feb;139 ( Pt 2):349-59.PMID: 8436953","","Fri Jan 25 15:17:55 2002","1","","","SMU.396","468" "SMu0360","373588","374346","759","ATGACAGTGTTTGAACAGATGGAGTTTTACTCACCCGTTTTACGGATTAATAATCGTGAAGAAAATATTGATTTCTATCAGAATACTTTAGGTTTCAAAGTGCTTTCGGAAGAGAATTCTTTGGTTATTTTTGGGGATTGGGCTCAAGCAGGCAGTCTCTTTTTGATTGAAGAGTCACCGGATATTCGTACAAGAGCAGTAAAAGGGACAAAAAAACTCAATAAAATAATTATCAAAGCTAGTAAGACTGAAGAAATTGCTGCTTTACTAGCTAATGGAGCTCAGGCAGATAAGGTTTTTAAAGGAGCTAATGGCTATGCTTTTGAGGCTATTTCTCCTGAAAAGGATCGCTTTCTTATTCATGCTGAAGATGATTTAACGACTCTTCAAGAGACTAAACAAGCGGATTATCAGCCTTTACCTGATTTTAAAGGGCTGTCAGCTTTCAAAGTGGAAAGTATGTGTTTAAATGTTCCCGATAAGGTAAAATCACAGAATTTTTATCAAGATCTTTTTCAAAATCAATTTCCAATTTTGTTAGATTTTGTTGAGAGTCATGGAGAGGATCTAACCATCCAGCCTCATATTGCCTGGGATCTGGAAATTTTAGAAATTCGAGTTGCTGAAAATTATGATCTTGTTGCTTTAAAGAATTATCTTGAAGAAAAAGGACAGGATGTCTACTTAGATAAGAAGGAAAAGATTTTGGTTTTTTCAGATCCAAGCCAGATTGAAATTTGGTTTCGTAAAGTAAAATGA","4.60","-12.30","28983","MTVFEQMEFYSPVLRINNREENIDFYQNTLGFKVLSEENSLVIFGDWAQAGSLFLIEESPDIRTRAVKGTKKLNKIIIKASKTEEIAALLANGAQADKVFKGANGYAFEAISPEKDRFLIHAEDDLTTLQETKQADYQPLPDFKGLSAFKVESMCLNVPDKVKSQNFYQDLFQNQFPILLDFVESHGEDLTIQPHIAWDLEILEIRVAENYDLVALKNYLEEKGQDVYLDKKEKILVFSDPSQIEIWFRKVK","374343","","C3-degrading proteinase","Cytoplasm","Similarities in gapped BLAST to predicted C3-degrading proteinases. Residues 1-250 are 54% similar to gi15675674 from S.pyogenes. Residues 12-251 are 37% similar to gi15903347 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1730 (1e-72).","

noIPR
unintegrated

unintegrated
SSF54593	$\"[2-128]T$ $\"[135-248]T$	SSF54593

InterPro
IPR001466
Family

Beta-lactamase
PF00144	$\"[6-300]T$	Beta-lactamase

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[3-297]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[3-306]T$	G3DSA:3.40.710.10
PTHR22935	$\"[10-223]T$	PTHR22935
PTHR22935:SF10	$\"[10-223]T$	PTHR22935:SF10

","BeTs to 6 clades of COG1680COG name: Beta-lactamase class C and other penicillin binding proteinsFunctional Class: MThe phylogenetic pattern of COG1680 is ---k---CEBR---------xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 15:28:09 2002","Thu Aug 31 17:02:36 2006","Thu Aug 31 17:02:36 2006","Thu Aug 31 17:02:36 2006","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0361 is paralogously related (blast p-value < 1e-3) to SMu0811, a predicted penicillin-binding protein.","Fri Jan 25 15:28:09 2002","","No significant hits to the NCBI PDB database.","SMU.400","","Residues 6 to 300 (E-value = 3.9e-41) place SMu0361 in the Beta-lactamase family which is described as Beta-lactamase (PF00144)","Fri Jan 25 15:27:21 2002","24378893","","","","","","1","","","SMU.400","603" "SMu0362","375867","375427","441","ATGAAAATTAATTATACTCGCGACACACTGTCATCCACCTATCTTGATGCAGTAAAAATTAGAAACATTGTCTTCGTTCAAGGACAAGGTGTCCCATTAACTATTGAAGTTGATAAGAACGAAGCACATTGCATTCATTTTGTACTTTATGATGACAAAAATAGGGCTGTTGCAACCTGTCGTCTTTTACCCACGCAGGATGGAATCACAGCGACCTTACAGCGCATGGCTGTTTTACCGAGCAATCGCGGTAAAAATTATGGAAAACTCATTCTGGATGCTGCAACAGACTTCGCCAAAAAGCAAGGTTATCAACAAATGACTTTACATGCTCAATTGAGTGCCAAAGGTTTCTACCAAAGAATGCAGTTTAAATCTTTAGGACAAGAATTTGAGGAAGCTGGCATTAAGCATATTACTATGACAAAAGCTTTGTCATAA","10.10","6.85","16427","MKINYTRDTLSSTYLDAVKIRNIVFVQGQGVPLTIEVDKNEAHCIHFVLYDDKNRAVATCRLLPTQDGITATLQRMAVLPSNRGKNYGKLILDAATDFAKKQGYQQMTLHAQLSAKGFYQRMQFKSLGQEFEEAGIKHITMTKALS","375430","","acetyltransferase","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-145 are 49% similar to gi15673798 from L.lactis. Residues 16-146 are 40% similar to gi15924044 from S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2164 (4e-16).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[48-125]T$	Acetyltransf_1
PS51186	$\"[3-146]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[3-144]T$	G3DSA:3.40.630.30
SSF55729	$\"[1-144]T$	SSF55729

","BeTs to 5 clades of COG0454COG name: Predicted acetyltransferasesFunctional Class: RThe phylogenetic pattern of COG0454 is AmTKYqVCEBR-uj----in-Number of proteins in this genome belonging to this COG is 8","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 20 13:54:07 2007","Tue Feb 20 13:54:07 2007","Tue Feb 20 13:54:07 2007","Tue Feb 20 13:54:07 2007","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0362 is paralogously related (blast p-value < 1e-3) to SMu1145.","Tue Feb 20 13:54:07 2007","","No significant hits to the NCBI PDB database.","SMU.401c","","Residues 48 to 125 (E-value = 1e-11) place SMu0362 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Fri Jan 25 15:30:44 2002","24378894","","","","","","1","","","SMU.401c","" "SMu0363","378356","376029","2328","ATGGCAACTGTCAAAACTAACACTGACGTTTTTGAAAAAGCCTGGGAAGGCTTTAAAGGAACTGACTGGAAAGACAGAGCAAGCATTTCTCGCTTTGTTCAAGACAACTACACTCCATATGACGGAGACGAAAGTTTTCTTGCCGGCCCTACTGAACGTTCACTTCACATCAAAAAAGTCGTAGAAGAAACTAAAGCGCATTACGAAGAAACACGTTTTCCAATGGATACACGTATTACATCTATTGCTGATATCCCAGCAGGTTATATTGACAAGGAAAATGAATTGATTTTTGGTATCCAAAACGATGAACTTTTTAAGCTGAACTTCATGCCAAAAGGCGGTATTCGCATGGCTGAAACAGCTTTGAAAGAACATGGTTATGAACCAGACCCTGCCGTTCATGAAATCTTTACCAAATATGCAACAACCGTTAATGATGGTATCTTTCGTGCTTACACTTCAAACATTCGCCGTGCACGTCATGCCCACACTGTAACTGGTCTCCCAGATGCATACTCTCGCGGACGTATTATTGGAGTTTATGCCCGTCTTGCTCTCTATGGTGCTGACTACTTGATGCAAGAAAAAGTGAACGACTGGAACTCAATTGCTGAAATTGATGAAGAATCAATTCGTCTTCGTGAAGAAATCAATCTTCAATATCAGGCACTTGGCGAAGTAGTGCGGTTGGGTGATCTGTATGGTCTTGATGTTCGCAAACCTGCTATGAATGTTAAAGAAGCTATCCAATGGATTAATATCGCCTTTATGGCTGTCTGCCGCGTTATCAATGGTGCTGCAACTTCTCTTGGACGTGTCCCAATCGTTCTTGATATCTTTGCAGAACGTGACCTTGCTCGTGGCACTTTCACTGAATCAGAAATCCAAGAATTCGTTGATGACTTCGTTATGAAACTTCGTACGGTTAAATTTGCACGTACTAAGGCTTATGACGAACTTTACTCAGGTGACCCAACATTTATTACGACTTCTATGGCTGGTATGGGAGCTGATGGACGTCACCGTGTTACTAAGATGGACTACCGTTTCTTAAATACGCTTGATAATATTGGCAATGCTCCAGAACCTAACTTAACCGTTCTTTGGTCAAGTAAATTGCCTTACCCTTTCCGTCATTATTGTATGTCTATGAGCCACAAGCATTCTTCAATTCAATATGAAGGTGTCACAACTATGGCTAAAGAAGGTTATGGTGAAATGTCATGTATCTCATGCTGTGTATCTCCGCTTGATCCTGAAAACGAAGATCGTCGCCACAATCTACAATACTTTGGTGCTCGTGTTAACGTTCTTAAAGCACTTCTTACAGGTCTTAATGGCGGTTACGACGATGTTCACAAAGACTACAAAGTATTTGATGTCGAACCTATCCGTGATGAAGTCCTTGATTTTGAAACGGTTAAAGCTAATTTTGAAAAAGCACTTGATTGGTTGACTGATACTTACGTGGACGCAATGAATATCATTCACTATATGACTGATAAATATAACTATGAAGCCGTTCAAATGGCCTTCTTACCAACACGTGTTAAAGCCAATATGGGATTTGGTATTTGCGGATTCTCTAATACAGTTGATTCATTATCAGCTATTAAATATGCTACTGTAAAACCTATTCGTGATGAAGATGGTTACATTTACGACTATGAAACTGTTGGTAACTTCCCTCGTTACGGAGAAGATGATGACCGTGTAGACTCAATCGCTGAATGGTTGCTTGAAGCTTTCCATACTCGTCTTGCACGTCATAAACTGTACAAAGATTCCGAAGCTACTGTATCATTGCTTACAATCACTTCTAATGTTGCTTATTCTAAACAAACTGGTAATTCTCCAGTTCACAAGGGTGTTTACCTCAATGAAGATGGTTCTGTGAACTTGTCTAAAGTAGAATTCTTCTCACCAGGTGCTAACCCATCAAATAAAGCTTCCGGCGGCTGGTTGCAAAACTTGAACTCATTGAAGAAACTTGACTTTGCTCACGCAAATGATGGTATCTCATTGACAACTCAAGTTTCACCAAAAGCTCTTGGTAAGACATTCGATGAACAAGTTGCTAACTTAGTAACAATTCTTGATGGTTACTTTGAAGGCGGCGGTCAACACGTTAACTTGAACGTTATGGATCTTAAAGATGTTTATGATAAGATCATGAATGGTGAAGATGTTATCGTTCGTATCTCAGGTTACTGTGTTAACACTAAATACCTTACTAAAGAACAAAAGACTGAATTGACACAACGTGTTTTCCATGAAGTTCTTTCAATGGATGATGCAGCTACAGACTTGGTTAACAACAAATAA","5.20","-22.67","87600","MATVKTNTDVFEKAWEGFKGTDWKDRASISRFVQDNYTPYDGDESFLAGPTERSLHIKKVVEETKAHYEETRFPMDTRITSIADIPAGYIDKENELIFGIQNDELFKLNFMPKGGIRMAETALKEHGYEPDPAVHEIFTKYATTVNDGIFRAYTSNIRRARHAHTVTGLPDAYSRGRIIGVYARLALYGADYLMQEKVNDWNSIAEIDEESIRLREEINLQYQALGEVVRLGDLYGLDVRKPAMNVKEAIQWINIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTFTESEIQEFVDDFVMKLRTVKFARTKAYDELYSGDPTFITTSMAGMGADGRHRVTKMDYRFLNTLDNIGNAPEPNLTVLWSSKLPYPFRHYCMSMSHKHSSIQYEGVTTMAKEGYGEMSCISCCVSPLDPENEDRRHNLQYFGARVNVLKALLTGLNGGYDDVHKDYKVFDVEPIRDEVLDFETVKANFEKALDWLTDTYVDAMNIIHYMTDKYNYEAVQMAFLPTRVKANMGFGICGFSNTVDSLSAIKYATVKPIRDEDGYIYDYETVGNFPRYGEDDDRVDSIAEWLLEAFHTRLARHKLYKDSEATVSLLTITSNVAYSKQTGNSPVHKGVYLNEDGSVNLSKVEFFSPGANPSNKASGGWLQNLNSLKKLDFAHANDGISLTTQVSPKALGKTFDEQVANLVTILDGYFEGGGQHVNLNVMDLKDVYDKIMNGEDVIVRISGYCVNTKYLTKEQKTELTQRVFHEVLSMDDAATDLVNNK","376032","For other 'pfl' genes see SMu1542 (pflA); SMu0444 (pflC) and SMu0446 (pfl-2), (pfl).","pyruvate formate-lyase","Cytoplasm","This sequence corresponds to the previously published gi|1129082 in GenBank, a predicted Pyruvate formate-lyase (PFL_STRMU). See also gi|3168596 from S.bovis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1727 (0.0).","

InterPro
IPR001150
Domain

Formate C-acetyltransferase glycine radical
PF01228	$\"[641-743]T$	Gly_radical
PS00850	$\"[732-740]T$	GLY_RADICAL_1
PS51149	$\"[642-762]T$	GLY_RADICAL_2

InterPro
IPR004184
Domain

Pyruvate formate-lyase, PFL
PF02901	$\"[14-613]T$	PFL

InterPro
IPR005949
Family

Formate acetyltransferase
PIRSF000379	$\"[12-762]T$	For_Ac_trans_1
TIGR01255	$\"[14-762]T$	pyr_form_ly_1

noIPR
unintegrated

unintegrated
G3DSA:3.20.70.20	$\"[5-762]T$	G3DSA:3.20.70.20
SSF51998	$\"[5-762]T$	SSF51998

","BeTs to 3 clades of COG1882COG name: Pyruvate-formate lyaseFunctional Class: CThe phylogenetic pattern of COG1882 is a-t-----E--H---------Number of proteins in this genome belonging to this COG is 2","***** IPB001150 (Pyruvate formate-lyase, glycine radical) with a combined E-value of 4.5e-25. IPB001150A 602-612 IPB001150B 711-760","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 18:30:12 2002","Fri Jan 25 15:31:56 2002","Sun Oct 27 18:30:12 2002","Wed Apr 10 15:47:19 2002","Fri Jan 25 15:31:56 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0363 is paralogously related (blast p-value < 1e-3) to SMu0446, another predicted pfl protein.","Fri Jan 25 15:44:03 2002","Fri Jan 25 15:31:56 2002","pdb|3PFL|A Chain A, Crystal Structure Of Pfl From E.Coli In Com... 619 4e-178pdb|1CM5|A Chain A, Crystal Structure Of C418a,C419a Mutant Of ... 612 5e-176pdb|1QHM|A Chain A, Escherichia Coli Pyruvate Formate Lyase Lar... 542 5e-155","SMU.402c","","Residues 641 to 743 (E-value = 8.9e-48) place SMu0363 in the Gly_radical family which is described as Glycine radical (PF01228)","Fri Jan 25 15:31:56 2002","","","Yamamoto,Y., Sato,Y., Takahashi-Abbe,S., Abbe,K., Yamada,T. andKizaki,H.Cloning and sequence analysis of the pfl gene encoding pyruvateformate-lyase from Streptococcus mutansInfect. Immun. 64 (2), 385-391 (1996)PubMed: 8550181Asanuma,N., Iwamoto,M. and Hino,T.Structure and transcriptional regulation of the gene encodingpyruvate formate-lyase of a ruminal bacterium, Streptococcus bovisMicrobiology 145 (Pt 1), 151-157 (1999)PubMed: 10206694Iwami Y, Takahashi-Abbe S, Takahashi N, Abbe K, Yamada T.Rate-limiting steps of glucose and sorbitol metabolism in Streptococcus mutans cells exposed to air.Oral Microbiol Immunol. 2000 Oct;15(5):325-8.PMID: 11154425","Melchiorsen CR, Jensen NB, Christensen B, Vaever Jokumsen K, Villadsen J.Dynamics of pyruvate metabolism in Lactococcus lactis.Biotechnol Bioeng. 2001 Aug 20;74(4):271-9.PMID: 11410851","Wed Apr 10 15:47:19 2002","Fri Jan 25 15:42:20 2002","1","","","SMU.402c","178" "SMu0364","378579","379691","1113","ATGCTTATTTTTCCGCTGATTAATGATACGTCACGAAAAATTATTCATATTGATATGGATGCCTTTTTTGCTGCAGTAGAAGAACGTGATAATCCTAAATTGAAAGGTAAACCGCTTGTAATTGGTGCTGACCCCCGTCAAACAGGCGGCCGTGGTGTTGTTTCGACAGCTAATTATTTGGCCAGAGAATTTGGTATTCACTCAGCCATGAGTTCAAAAGAAGCTTACGAACGTTGTCCGCAAGCTATTTTTATCAGAGGCAATCATACTAAATACCGTCAAATTGGATTACAAGTCAGAGAAATTTTTAGGCGTTATACAGATTTGGTAGAACCCATGAGTATTGATGAAGCCTATTTAGATGTTACTGAAAATAAATTGAACATAAAATCAGCAGTGAAGATTGCTAAACTTATCCAACGCGATATTTGGGAAGAATTTCATTTAACTTGTTCTGCTGGTGTCTCCTACAATAAATTTTTAGCTAAGTTGGCTAGCGATTATGATAAGCCGCATGGTTTAACAGTCATTTTGCCACAGGATGCAGAAGGCTTCTTAGCAACCTTACCTATTGAAAAGTTTTATGGTGTGGGGAAAAAATCTGTTGAGAAACTGCATGCTCTTCATATCTTTACGGGTAAGGATGTGCAACAGGTGCCGGAAATGACCTTGATTGATCTTTTTGGGCGTTTTGGCTTTGATCTGTATCGAAAAGCACGTGGTATCAGTAATTCTCCTGTCAAAAACGACCGCATTCGTAAATCTATTGGCAGTGAGAGGACCTATGGGAAATTGCTTTATAATGATGAAGATATTAAACTGGAACTATCAAAGACTGCCAGACGAGTAGCTGACAGTTTAAAAAAGCATGGGCGCAAAGGAAAGATTGTCGTTATTAAAGTTCGTTATTCGGATTTTTCAACACTGACCAAGCGAAAAACCTTAGATGTACCCACTCAGGATTTTGAAGTTATTGAACGTTCAGCTCATCGCATTTTTGATCATCTGACAGAAAATAATTCTGGTGTCCGTCTTTTAGGTGTAACAGTAACTGCTCTGGAAGATAGTACCAGAGAGGAGCTTTCCTTAACAGCAGACGATTTTAAGACTTAA","10.00","11.34","41984","MLIFPLINDTSRKIIHIDMDAFFAAVEERDNPKLKGKPLVIGADPRQTGGRGVVSTANYLAREFGIHSAMSSKEAYERCPQAIFIRGNHTKYRQIGLQVREIFRRYTDLVEPMSIDEAYLDVTENKLNIKSAVKIAKLIQRDIWEEFHLTCSAGVSYNKFLAKLASDYDKPHGLTVILPQDAEGFLATLPIEKFYGVGKKSVEKLHALHIFTGKDVQQVPEMTLIDLFGRFGFDLYRKARGISNSPVKNDRIRKSIGSERTYGKLLYNDEDIKLELSKTARRVADSLKKHGRKGKIVVIKVRYSDFSTLTKRKTLDVPTQDFEVIERSAHRIFDHLTENNSGVRLLGVTVTALEDSTREELSLTADDFKT","379688","For other 'din' genes see SMu0109 (dinF) and SMu1200 (dinG). ","nucleotidyltransferase/DNA polymerase involved in DNA repair ","Cytoplasm","Residues 1-25 of this sequence correspond to the previously published gi1311550 in GenBank, designated ORF1 (see Yamamoto et al., 1996). Similarities in gapped BLAST are to DNA-damage-inducible protein P sequences, e.g. residues 1-359 are 74% similar to gi15675671 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1726 (1e-154).","

InterPro
IPR001126
Domain

UMUC-like DNA-repair protein
PF00817	$\"[17-355]T$	IMS
PS50173	$\"[14-198]T$	UMUC

noIPR
unintegrated

unintegrated
G3DSA:3.30.1490.100	$\"[250-365]T$	G3DSA:3.30.1490.100
G3DSA:3.30.70.270	$\"[79-177]T$	G3DSA:3.30.70.270
PTHR11076	$\"[16-367]T$	PTHR11076
PTHR11076:SF12	$\"[16-367]T$	PTHR11076:SF12
SSF100879	$\"[251-352]T$	SSF100879
SSF56672	$\"[9-286]T$	SSF56672

","BeTs to 6 clades of COG0389COG name: Nucleotidyltransferase/DNA polymerase involved in DNA repairFunctional Class: LThe phylogenetic pattern of COG0389 is ----Y--cEBR---gp-----Number of proteins in this genome belonging to this COG is 1","***** IPB001126 (UMUC family (DNA-repair)) with a combined E-value of 1.7e-44. IPB001126A 18-36 IPB001126B 110-121 IPB001126C 137-171 IPB001126D 186-205","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 10:46:23 2007","Fri Mar 16 10:46:23 2007","Tue Sep 19 11:00:58 2006","Thu Apr 4 13:58:45 2002","Fri Jan 25 16:16:38 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0364 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 16:19:57 2002","","No significant hits to the NCBI PDB database.","SMU.403","","Residues 17 to 355 (E-value = 3.5e-105) place SMu0364 in the IMS family which is described as impB/mucB/samB family (PF00817)","Fri Jan 25 16:16:38 2002","24378896","","Yamamoto,Y., Sato,Y., Takahashi-Abbe,S., Abbe,K., Yamada,T. andKizaki,H.Cloning and sequence analysis of the pfl gene encoding pyruvateformate-lyase from Streptococcus mutansInfect. Immun. 64 (2), 385-391 (1996)PubMed: 8550181","Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T.Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.Nat Struct Biol. 2001 Nov;8(11):984-9.PMID: 11685247Lovett CM Jr, Love PE, Yasbin RE.ompetence-specific induction of the Bacillus subtilis RecA protein analog: evidence for dual regulation of a recombinationprotein.J Bacteriol. 1989 May;171(5):2318-22.PMID: 2496103","Wed Apr 10 09:39:32 2002","Fri Jan 25 16:29:03 2002","1","","","SMU.403","467" "SMu0365","380020","379697","324","ATGATGATACAACAAATAATGTTAATAATCAGTCTTTTTCTCTTTTTGATAGGTGCTATTTTAACCAGCTATCAAATTTTTAAAATTGTTGAACTTGATGCACGAGCTAGAGGACTAAATAATCCCGAACTTTGGGGACTTTCTACTGCTGGCAGAGGAAATATTATCGGTCTTATTCTCTATTTTAAACATCGGGAAGATTATCCTATCAAAAACTTTCCACCCAAAAAGCAGGCAGAGAGTTCAAAACGTAAGAGATGGGCTATCCTTACCCTTTTTCTAGCAGGACTTGGTGCTGTTGGTATCGTTTTAGCTACTTTTTAG","11.00","7.22","12048","MMIQQIMLIISLFLFLIGAILTSYQIFKIVELDARARGLNNPELWGLSTAGRGNIIGLILYFKHREDYPIKNFPPKKQAESSKRKRWAILTLFLAGLGAVGIVLATF","379700","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu0365 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-19]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[44-62]?$ $\"[87-105]?$	transmembrane_regions

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[7-61]T$	HTH_3
SM00530	$\"[6-61]T$	HTH_XRE
PS50943	$\"[7-61]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[2-73]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[1-73]T$	G3DSA:1.10.260.40

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[5-265]T$	Cof-subfamily

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[5-237]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[6-265]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[1-269]T$	G3DSA:3.40.50.1000
SSF56784	$\"[1-270]T$	SSF56784

InterPro
IPR009793
Family

Protein of unknown function DUF1361
PF07099	$\"[26-191]T$	DUF1361

InterPro
IPR006043
Family

Xanthine/uracil/vitamin C permease
PTHR11119	$\"[1-152]T$ $\"[176-468]T$	Xant/urac/vitC
PF00860	$\"[15-437]T$	Xan_ur_permease

noIPR
unintegrated

unintegrated
PTHR11119:SF9	$\"[1-152]T$ $\"[176-468]T$	PTHR11119:SF9

","BeTs to 8 clades of COG2252COG name: PermeasesFunctional Class: RThe phylogenetic pattern of COG2252 is -m-k--v-EB-huj--Ol---Number of proteins in this genome belonging to this COG is 1","***** IPB000444 (Xanthine/uracil permeases family) with a combined E-value of 7.3e-10. IPB000444A 328-357 IPB000444B 365-408 IPB000444B 369-412 IPB000444B 412-455","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 15:36:26 2002","Tue Jul 25 08:47:16 2006","Tue Jul 25 08:47:16 2006","Tue Oct 8 08:59:11 2002","Mon Jan 28 15:33:01 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0369 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 28 15:36:26 2002","","No significant hits to the NCBI PDB database.","SMU.408","","Residues 15 to 437 (E-value = 9.7e-24) place SMu0369 in the Xan_ur_permease family which is described as Permease family (PF00860)","Mon Jan 28 15:33:01 2002","24378901","","","","","","1","","","SMU.408","47" "SMu0370","383904","384347","444","ATGTTTTATAGCCAAAATGAAAATCAGCTAATGGCTCTTGGACAGAGAATTGGTCAAAAACTACAAGCTCAAGACGTTCTTGTTCTGACAGGCGATTTAGGATCTGGGAAAACCACTCTGACAAAAGGAATTGCCAAAGGTTTGGGGATTAAGCAGATGATTAAGAGTCCAACCTATACGATTGTTCGTGAATATGAGGGAAGGCTGCCACTTTATCATTTGGATGTCTATCGAATTGGTGATGATCCTGATTCTATTGATCTGGATGATTTTCTTTTTGGAGATGGCGTAACAGTGATTGAGTGGGGAGAGCTCTTAGACGATAGCCTTTTGAGCGATTATTTGACAGTCCTTTTAGATAAAACAGAGGGTGGCAGACAAATTACTTTATTACCTCATGGCCTGCGCTCTCAGCAATTGGTTGCGGAACTTGAGCATGACTGA","4.40","-9.28","16364","MFYSQNENQLMALGQRIGQKLQAQDVLVLTGDLGSGKTTLTKGIAKGLGIKQMIKSPTYTIVREYEGRLPLYHLDVYRIGDDPDSIDLDDFLFGDGVTVIEWGELLDDSLLSDYLTVLLDKTEGGRQITLLPHGLRSQQLVAELEHD","384344","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-146 are 58% similar to gi|15675584 from S.pyogenes. Residues 3-146 are 54% similar to gi|15901768 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0366 (2e-43).","

InterPro
IPR003442
Domain

Protein of unknown function UPF0079, ATPase bacteria
PF02367	$\"[10-129]T$	UPF0079
TIGR00150	$\"[3-134]T$	UPF0079_ATPase_bac

InterPro
IPR012298
Family

ATPase, cell wall biosynthesis
PIRSF006361	$\"[1-146]T$	ATPase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-146]T$	G3DSA:3.40.50.300
SSF52540	$\"[11-118]T$	SSF52540

","BeTs to 11 clades of COG0802COG name: Predicted nucleotide-binding protein, YjeE familyFunctional Class:� RThe phylogenetic pattern of COG0802 is -----qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003442 (Uncharacterised P-loop hydrolase UPF0079) with a combined E-value of 1.7e-31. IPB003442A 21-49 IPB003442B 55-79 IPB003442C 95-104","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 15:39:23 2002","Mon Jan 28 15:39:23 2002","Mon Jan 28 15:39:23 2002","Mon Jan 28 15:39:23 2002","Mon Jan 28 15:39:23 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0370 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 28 15:39:23 2002","","No significant hits to the NCBI PDB database.","SMU.409","","Residues 10 to 129 (E-value = 1.4e-41) place SMu0370 in the UPF0079 family which is described as Uncharacterised P-loop hydrolase UPF0079 (PF02367)","Mon Jan 28 15:39:23 2002","24378902","","","","","","1","","","SMU.409","763" "SMu0371","384678","385898","1221","ATGAAGATTGGTAAAAAAATTCTAATTATGCTGGTTACAATATTTCTCACAAGCTTGGTAGCTTTAGGAGTTTATGCAACGAGTATTTATAACTTTTCTTTAGGAGAATTTTCAAAAACTTTTAAAGATTATGGCACAGGTTCAGGTAAAGACGTTATTGCTGATGAAAAACCTTTTAGTATCCTCTTAATGGGAGTTGACACGGGCTCTTCCGAGAGGACTTCCAAATGGGAAGGTAACAGTGACTCTATGATTTTGGTAACGGTTAATCCCAAAACTAAAAAGACAACCATGACCAGTTTAGAACGGGATATCTTGGTTAAATTATCTGGATCTAAAACTAATGACCAGACTGGTTATGATGCCAAGCTTAATGCAGCCTATGCTGCTGGAGGTGCTAAGATGGCTATTATGACAGTTCAGGATATGCTTGATATTAAGATTGATAAATATGTTCAAATTAATATGGAAGGGCTGGTTCAGTTGGTTGATGCTGTAGGTGGTATTACGGTAACCAATCATTTTGATTTTCCAATTTCAATTGAAGAACATGAGCCTGAATTTACAGCATCAGTTGAGCCCGGGACTCACAAGATTAATGGGGAGCAGGCCCTCGTTTATTCGCGAATGCGTTATGATGATCCAGATGGAGACTATGGCCGTCAAAAGCGTCAACGTGAGGTCATCAGCAAGGTCTTAAAGAAAATTTTAGCTTTAGACAGTGTCAGCAAGTATCGTAAAATTTTATCAGCTGTCAGCAAGAATATGCAGACTAATATTGAAATTTCCAGCAGTACTATTCCTAAACTTTTGGGGTACAGCGATGCTCTCAAGAGTATTAGGACTTATCAGCTCAAGGGAGAAGGAACGACTATTGACGGTGGTTCTTATCAGCTAGTAACCAGCAAGGAATTGCTAAAAGCTCAAAATCGTATTAAAGGACAATTAGGGCTGAAAAAATCAACTGCTGAAAATCTGAAAACAACGGCTAGTCTTTATGAGAATTTTTATGGAGGCGATACGAGTATTTATGACAGTAGCTCCAGTGCCTCAGATTACAGTAGCAGCGGTAATTATTCTGGCTCAAGTTCAGATTATGGTTCTAGTTCTTCTTATGGCTCCAATTCGAGTTCTGGTTCTTCCAGTGATTATTCTGGACAAAATAGTTATAATCAAGGAAATTACCAACAACCTGCTGCAGGAACGGGAATTGGTAATTAA","8.70","1.74","43898","MKIGKKILIMLVTIFLTSLVALGVYATSIYNFSLGEFSKTFKDYGTGSGKDVIADEKPFSILLMGVDTGSSERTSKWEGNSDSMILVTVNPKTKKTTMTSLERDILVKLSGSKTNDQTGYDAKLNAAYAAGGAKMAIMTVQDMLDIKIDKYVQINMEGLVQLVDAVGGITVTNHFDFPISIEEHEPEFTASVEPGTHKINGEQALVYSRMRYDDPDGDYGRQKRQREVISKVLKKILALDSVSKYRKILSAVSKNMQTNIEISSSTIPKLLGYSDALKSIRTYQLKGEGTTIDGGSYQLVTSKELLKAQNRIKGQLGLKKSTAENLKTTASLYENFYGGDTSIYDSSSSASDYSSSGNYSGSSSDYGSSSSYGSNSSSGSSSDYSGQNSYNQGNYQQPAAGTGIGN","385895","","transcriptional regulator","Membrane, Extracellular","Matches in gapped BLAST to transcriptional regulators and hypotheticals. Residues 1-335 are 70% similar to gi|15675582 from S.pyogenes. Residues 5-335 are 49% similar to gi|15901766 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0368 (1e-124).","

InterPro
IPR004474
Domain

Cell envelope-related transcriptional attenuator
PF03816	$\"[80-238]T$	LytR_cpsA_psr
TIGR00350	$\"[79-238]T$	lytR_cpsA_psr

","BeTs to 5 clades of COG1316COG name: Transcriptional regulators, LytR familyFunctional Class:� KThe phylogenetic pattern of COG1316 is ------vC-BR-----ol---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 15:44:39 2002","Mon Jan 28 15:42:43 2002","Mon Jan 28 15:44:39 2002","Mon Jan 28 15:42:43 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0371 is paralogously related (blast p-value < 1e-3) to SMu0714, a predicted transcriptional regulator, and to SMu0424, a predicted penicillin-binding protein.","Mon Jan 28 15:44:39 2002","","No significant hits to the NCBI PDB database.","SMU.410","","Residues 80 to 238 (E-value = 5.4e-75) place SMu0371 in the LytR_cpsA_psr family which is described as Cell envelope-related transcriptional attenuator domain (PF03816)","Mon Jan 28 15:42:43 2002","24378903","","","","","","1","","","SMU.410","271" "SMu0372","386361","386068","294","ATGAAAATTAAAACTTTCATTCTTTCAAGCCTTCTTGGAGCCGGTCTTTATCAGATGTATTACAAACGCAAAGATATCAAGACTTCTTTCAAGGAAAGCAAAACACATTATGACAAAGCTAAATTCGATCTTAATAACATTAAAGAAAATTTAGCGATAATAGAGCAGCAAAAAGAAAAGATACAAGCTATCAATCAAGATTTAACTTATAAAATCCGTGTCTTTCAAAAAGAAAGCCAATCTCACATGGACGAAATTCAAAAAATAGTTGCTAGATATCACCAAGAAGACTAG","10.20","5.71","11601","MKIKTFILSSLLGAGLYQMYYKRKDIKTSFKESKTHYDKAKFDLNNIKENLAIIEQQKEKIQAINQDLTYKIRVFQKESQSHMDEIQKIVARYHQED","386071","","Streptococcus-specific protein","Cytoplasm, Extracellular","Single match in gapped BLAST to gi15675581, a hypothetical from S.pyogenes. Residues 1-96 are 37% similar to this sequence.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0369 (7e-12).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-18]?$	signal-peptide

InterPro
IPR001310
Family

Histidine triad (HIT) protein
PR00332	$\"[5-21]T$ $\"[26-44]T$ $\"[93-103]T$	HISTRIAD
PIRSF000714	$\"[1-136]T$	HIT
PTHR23089	$\"[19-138]T$	HIT
PF01230	$\"[11-108]T$	HIT
PS51084	$\"[5-112]T$	HIT_2

InterPro
IPR008162
Family

Inorganic pyrophosphatase
PS00387	$\"[108-114]?$	PPASE

noIPR
unintegrated

unintegrated
G3DSA:3.30.428.10	$\"[2-107]T$	G3DSA:3.30.428.10
SSF54197	$\"[3-138]T$	SSF54197

","BeTs to 14 clades of COG0537COG name: Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolasesFunctional Class: F,G,RThe phylogenetic pattern of COG0537 is amTKYQ-cebRhUJgpo-inxNumber of proteins in this genome belonging to this COG is 2","***** IPB001310 (HIT (Histidine triad) family) with a combined E-value of 4.5e-30. IPB001310A 14-44 IPB001310B 80-106","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 15:56:32 2002","Mon Jan 28 15:48:42 2002","Fri Feb 17 13:36:52 2006","Fri Feb 17 13:35:51 2006","Mon Jan 28 15:48:42 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0373 is paralogously related (blast p-value < 1e-3) to SMu0313, a predicted HIT hydrolase.","Mon Jan 28 15:57:27 2002","Fri Feb 17 13:35:51 2006","pdb1EMSA Chain A, Crystal Structure Of The C. Elegans Nitfhit... 61 9e-011","SMU.412c","","Residues 4 to 108 (E-value = 1.5e-41) place SMu0373 in the HIT family which is described as HIT domain (PF01230)","Mon Jan 28 15:48:42 2002","24378905","","","","","","1","","","SMU.412c","764" "SMu0374","386842","387567","726","ATGTTAAAAATAGAAAATTTGACCGGTGGTTACGTCAACATTCCTGTCTTGAAAAATATCAGTTTTGAGGTTGCTGATGGTGAGTTGGTCGGGCTCATAGGCCTCAATGGTGCAGGAAAATCAACAACTATCAATGAAATTATTGGACTTTTGCAGCCTTATGAAGGCAAAATCAGTATTGATGGACTGACGCTTGCAGATCAAGAAATGGCTTATCGAAAGAAAATTGGGTTTATTCCAGAAACGCCTAGCCTTTACGAAGAATTAACCTTAAAAGAGCACTTGGAGATGATAGCCATGGCTTATGATATTAAAGTGGAAGCAGCTTTGGCGCGTGCGCAAAAACTGCTGGAACTTTTTAGATTAGAAGATAAACTGGATTGGTTTCCTATTCATTTTTCCAAAGGAATGAAACAAAAGGTCATGATTATCTGTGCCTTTATCATTGATCCGAGTCTTTTTATTGTTGATGAGCCTTTCTTGGGATTGGATCCTGTTGCCATTTCAGATTTGACTCAGCTTTTGGCAGCAGAAAAGGCTAAGGGAAAATCCATTTTGATGTCAACTCATGTTTTGGATTCTGCTGAAAAGATGTGTGATCGCTTTGTTATTTTACATCATGGACAAATCCGAGCTCAAGGAAGTCTCGCTGATTTACGAATGACTTTTGGAAATGCACAAGCCAGCCTTAACGATATCTATATGACTTTGACTAAAGAGGGTTGA","5.10","-6.88","26672","MLKIENLTGGYVNIPVLKNISFEVADGELVGLIGLNGAGKSTTINEIIGLLQPYEGKISIDGLTLADQEMAYRKKIGFIPETPSLYEELTLKEHLEMIAMAYDIKVEAALARAQKLLELFRLEDKLDWFPIHFSKGMKQKVMIICAFIIDPSLFIVDEPFLGLDPVAISDLTQLLAAEKAKGKSILMSTHVLDSAEKMCDRFVILHHGQIRAQGSLADLRMTFGNAQASLNDIYMTLTKEG","387564","For other components see SMu0375 (MSD1).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several matches in gapped BLAST to ABC transporter, ATP-binding proteins. Residues 1-240 are 77% similar to gi|15675579 from S.pyogenes and are 72% similar to gi|15902503 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0373 (1e-110).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[133-175]T$	ABC_transporter
PF00005	$\"[27-208]T$	ABC_tran
PS00211	$\"[133-147]?$	ABC_TRANSPORTER_1
PS50893	$\"[2-232]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-211]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-233]T$	G3DSA:3.40.50.300
SSF52540	$\"[1-219]T$	SSF52540

InterPro
IPR010288
Family

Bacterial ABC transporter EcsB
PF05975	$\"[1-342]T$	EcsB

InterPro
IPR002575
Domain

Aminoglycoside phosphotransferase
PF01636	$\"[9-225]T$	APH

InterPro
IPR002110
Repeat

Ankyrin
PR01415	$\"[37-49]T$ $\"[86-98]T$	ANKYRIN

InterPro
IPR003358
Family

Putative methyltransferase
PF02390	$\"[23-211]T$	Methyltransf_4

InterPro
IPR004395
Family

Conserved hypothetical protein 91
TIGR00091	$\"[23-211]T$	CHP91

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[43-117]T$	G3DSA:3.40.50.150
PTHR23417	$\"[4-209]T$	PTHR23417
PTHR23417:SF1	$\"[4-209]T$	PTHR23417:SF1
SSF53335	$\"[1-196]T$	SSF53335

","BeTs to 12 clades of COG0220COG name: Predicted S-adenosylmethionine-dependent methyltransferaseFunctional Class: RThe phylogenetic pattern of COG0220 is ----yqvcebrhujgp-linxNumber of proteins in this genome belonging to this COG is 1","***** IPB003358 (Putative methyltransferase) with a combined E-value of 1.1e-43. IPB003358A 43-69 IPB003358B 108-126 IPB003358C 127-166","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 23 17:13:37 2006","Wed Aug 23 17:13:37 2006","Wed Aug 23 17:13:37 2006","Wed Aug 23 17:13:37 2006","Mon Jan 28 16:11:56 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0377 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Aug 23 17:13:37 2006","","No significant hits to the NCBI PDB database.","SMU.416","","Residues 23 to 211 (E-value = 4.4e-59) place SMu0377 in the Methyltransf_4 family which is described as Putative methyltransferase (PF02390)","Mon Jan 28 16:11:56 2002","24378909","","","","","","1","","","SMU.416","530" "SMu0378","390362","390853","492","GTGTGTAAGGAGGGAAATACTATCGCAACGCTTGTTGATATTGTAAGGCCAGTAGTCGCACCTGTCATTCCAAAACCTTTTGAATTGGTTGATATCGAGTATGAAAAATTAGGTGGAAACTATGTACTCAGTATTTTAGTTGATAAACCAGAAGGGATTACGGTTGAAGATACAGCTGATTTGACAGATATTATCAGTCCTTTGCTTGATACTATAAAGCCTGATCCATTTCCAGAACAATACATGTTGGAAATTTCAAGTCCTGGTCTAGAACGCCCCTTAAAAACTGCCCAGAGTTTAATGAATGCTGTTGGTCATTATATCAATGTCAGTCTTTATCAAGCTATTGATAAGGTCAAAGTTTTTGAAGGTGATTTGACTGCCTTTGATGGTGAAACACTAAAAATGACTTATTTAGATAAAACACAGCAGAAAACTGTTACTATCCCCTATAAGATGGTCGCCAAAGCCCGTCTTGCTGTAAAACTATAG","4.70","-5.81","18022","MCKEGNTIATLVDIVRPVVAPVIPKPFELVDIEYEKLGGNYVLSILVDKPEGITVEDTADLTDIISPLLDTIKPDPFPEQYMLEISSPGLERPLKTAQSLMNAVGHYINVSLYQAIDKVKVFEGDLTAFDGETLKMTYLDKTQQKTVTIPYKMVAKARLAVKL","390850","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 6-163 are 70% similar to gi|15900464 from S.pneumoniae. Residues 37-163 are 77% similar to gi|15675575 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0377 (5e-56).","

InterPro
IPR003728
Family

Protein of unknown function DUF150
PF02576	$\"[18-159]T$	DUF150

noIPR
unintegrated

unintegrated
G3DSA:2.30.30.180	$\"[95-163]T$	no description
G3DSA:3.30.300.70	$\"[2-88]T$	no description

","BeTs to 9 clades of COG0779COG name: Uncharacterized BCR, YhbC familyFunctional Class:� SThe phylogenetic pattern of COG0779 is -----qvcebrhuj--ol--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 16:14:45 2002","Mon Jan 28 16:14:45 2002","Mon Jan 28 16:14:45 2002","Mon Jan 28 16:14:45 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0378 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 28 16:14:45 2002","","No significant hits to the NCBI PDB database.","SMU.417","","Residues 18 to 159 (E-value = 6e-58) place SMu0378 in the DUF150 family which is described as Uncharacterised BCR, YhbC family COG0779 (PF02576)","Mon Jan 28 16:14:45 2002","24378910","","","","","","1","","","SMU.417","765" "SMu0379","390889","392082","1194","ATGAGCCAAGAAATGCTAGAAGCCTTCCGTATTCTGGAAGAGGAAAAACACATTAACAAAGATGATATTATTGATGCGGTTAAAGAATCATTAAAGTCAGCTTATAAACGTCGCTATGGGCAGGCAGAAAGTGCTGAGATTGAATTTGACGAAAAGTCAGGAGACTTTAAAGTCTTCACTGTTCGTGAAGTTGTTGAAGAAGTTTTTGACAGCCGCCTTGAGATCAGCTTGAAGGACGCCCTTGCGATCAGTACAGCCTATGAACTTGGAGATAAAATTCGTTTTGAAGAGTCTCCCAAGGAATTTGGTCGCGTGGCTGCCCAGTCAGCTAAACAAACGATCATGGAAAAAATGCGCCGTCAAATGCGTGAAGTCACTTTTAATGAGTATAAAGAGCATGAAAGAGAAATCATGACAGGGACTGTTGAGCGTTTTGATAATCGCTTTATCTATGTTAATTTAGGAACGATAGAAGCGCAGCTGTCACGTCAAGATCAAGTTCCGGGTGAAACGTTTGCTTCTCATGATCGCATTGAAGTTTATGTTTATAAAGTAGAAAACAATCCTAAGGGCGTCAATGTCTTCGTTAGTCGCAGTCATCCTGAATTTATCAAGCGTATTATGGAACAGGAAATTCCTGAAGTTTTTGATGGCACTGTTGAAATTATGAGCGTAGCACGTGAAGCTGGTGATCGAACGAAGGTTGCGGTTCGCAGTCATAATCCTAATGTTGATGCTATTGGAACTATAGTTGGCCGCAAAGGTGCCAACATTAAGAAAGTGACCAGTAAATTCCATCCTAAACGTTTTGATCAAAAAACTGGACTTTGGGTTCCAATGGAAGAGAATGTTGATGTTATTGAGTGGGTTGATGATCCAGCAGAATTCATTTATAATGCTGTTGCTCCTGCTGAGGTTGATCAAGTTCTCTTTGATGAAGAAGATGACAAACATGCAACAGTTGTTGTACCAGACAATAAGCTGTCACTTGCTATTGGCCGTCGTGGTCAAAATGTCCGTTTAGCCGCTCATTTGACTGGCTATCGTATTGATATTAAGTCTGCTAGTGAATTTGAAGAAATGGAAGCCGAGTGGGCAGCACAAGATGAAACCCAAGAGGCTACTTATGAAGAGGCTCCTGCTGAGGAAGTTTCTGAACTCTCTCAAGAATTTGCAGCAGAAGATGCAAAATAG","4.60","-26.99","45449","MSQEMLEAFRILEEEKHINKDDIIDAVKESLKSAYKRRYGQAESAEIEFDEKSGDFKVFTVREVVEEVFDSRLEISLKDALAISTAYELGDKIRFEESPKEFGRVAAQSAKQTIMEKMRRQMREVTFNEYKEHEREIMTGTVERFDNRFIYVNLGTIEAQLSRQDQVPGETFASHDRIEVYVYKVENNPKGVNVFVSRSHPEFIKRIMEQEIPEVFDGTVEIMSVAREAGDRTKVAVRSHNPNVDAIGTIVGRKGANIKKVTSKFHPKRFDQKTGLWVPMEENVDVIEWVDDPAEFIYNAVAPAEVDQVLFDEEDDKHATVVVPDNKLSLAIGRRGQNVRLAAHLTGYRIDIKSASEFEEMEAEWAAQDETQEATYEEAPAEEVSELSQEFAAEDAK","392097","For other 'nus'genes see SMu1769 (nusG) and SMu1680 (nusB).","transcription termination-antitermination factor NusA; elongation factor","Cytoplasm","Matches in gapped BLAST to NusA proteins. Residues 1-384 are 81% similar to the predicted nusA from S.pyogenes (>gi15675574). Residues 1-378 are 78% similar to gi15902522 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0378 (1e-171).","

InterPro
IPR003029
Domain

RNA binding S1
PF00575	$\"[131-197]T$	S1
SM00316	$\"[133-199]T$	S1

InterPro
IPR004087
Domain

KH
SM00322	$\"[229-306]T$ $\"[315-393]T$	KH

InterPro
IPR004088
Domain

KH, type 1
PF00013	$\"[318-367]T$	KH_1
PS50084	$\"[316-357]T$	KH_TYPE_1

InterPro
IPR009019
Domain

KH, prokaryotic type
G3DSA:3.30.300.20	$\"[213-305]T$ $\"[306-358]T$	KH_prok
SSF54814	$\"[199-291]T$ $\"[292-358]T$	KH_prok

InterPro
IPR010213
Domain

Transcription termination factor NusA
TIGR01953	$\"[4-357]T$	NusA

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[150-212]T$	OB_NA_bd_sub

InterPro
IPR013735
Domain

NusA N-terminal
PF08529	$\"[4-125]T$	NusA_N

noIPR
unintegrated

unintegrated
G3DSA:3.30.1480.10	$\"[1-134]T$	G3DSA:3.30.1480.10
PTHR22648	$\"[1-390]T$	PTHR22648
SSF50249	$\"[131-198]T$	Nucleic_acid_OB
SSF69705	$\"[1-126]T$	SSF69705

","BeTs to 16 clades of COG0195COG name: Transcription terminator NusAFunctional Class: KThe phylogenetic pattern of COG0195 is amTK-qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","Mon Dec 3 12:41:37 2001","Mon Dec 3 12:41:37 2001","Mon Dec 3 12:41:37 2001","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","Thu Nov 29 19:14:41 2001","Mon Dec 3 12:41:37 2001","","Thu Sep 7 09:35:35 2006","Mon Jan 28 16:17:55 2002","Thu Sep 7 09:35:35 2006","Mon Dec 3 12:41:37 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0379 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 28 16:20:40 2002","","No significant hits to the NCBI PDB database.","SMU.418","Thu Nov 29 19:14:41 2001","Residues 320 to 364 (E-value = 5e-05) place SMu0379 in the KH family which is described as KH domain (PF00013)","Mon Dec 3 12:41:37 2001","24378911","","","Gopal B, Haire LF, Gamblin SJ, Dodson EJ, Lane AN, Papavinasasundaram KG, Colston MJ, Dodson G.Crystal Structure of the Transcription Elongation/Anti-termination Factor NusA from Mycobacterium tuberculosis at 1.7 A Resolution.J Mol Biol. 2001 Dec 14;314(5):1087-95.PMID: 11743725Artsimovitch I, Svetlov V, Anthony L, Burgess RR, Landick R.RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro.J Bacteriol. 2000 Nov;182(21):6027-35.PMID: 11029421","","Mon Jan 28 16:25:07 2002","1","","","SMU.418","274" "SMu0380","392100","392396","297","ATGGCAAAGACAAGAAAAATACCTTTAAGAAAGTCTCTTGTTTCAGGAGAGATTATTGATAAACGTGATTTGCTTCGGATTGTTAAAACCAAGGAAGGTGATGTTTTTATTGATCCTACTGGTAAGAAAAATGGGCGAGGGGCTTATATTAAACTTGCTAACGAAGAAGCTTTAGAAGCTAAAAAAAGAAAAGTCTTTAATCGCAGTTTTTCCATGGAAATTCCTGAAAGCTTTTATGATGAATTAATTGCTTTTGTTGATCATAAGGTTAAAAGAAGAGAGTTAGGTCTTGAATAA","10.60","7.23","11304","MAKTRKIPLRKSLVSGEIIDKRDLLRIVKTKEGDVFIDPTGKKNGRGAYIKLANEEALEAKKRKVFNRSFSMEIPESFYDELIAFVDHKVKRRELGLE","392393","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 3-98 are 87% similar to gi|15826607, a predicted Chain A, Hypothetical Cytosolic Protein Coded By Gene From NusaINFB, Ylxr Homologue, from S.pneumoniae. Residues 1-98 are 82% similar to gi|15675573 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0379 (3e-43).","

InterPro
IPR007393
Family

Protein of unknown function DUF448
PF04296	$\"[7-86]T$	DUF448

noIPR
unintegrated

unintegrated
G3DSA:3.30.1230.10	$\"[2-98]T$	G3DSA:3.30.1230.10
SSF64376	$\"[5-98]T$	SSF64376

InterPro
IPR004038
Family

Ribosomal protein L7Ae/L30e/S12e/Gadd45
PD004495	$\"[16-76]T$	RXL7_BACST_Q9EV99;
PF01248	$\"[5-96]T$	Ribosomal_L7Ae

","BeTs to 3 clades of COG1358COG name: Ribosomal protein HS6-type (S12/L30/L7a)Functional Class: JThe phylogenetic pattern of COG1358 is amtkY-v--B-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 09:00:07 2002","Thu Sep 7 10:33:57 2006","Thu Sep 7 10:33:57 2006","Tue Oct 8 09:00:07 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0381 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 09:00:07 2002","","No significant hits to the NCBI PDB database.","SMU.420","","Residues 5 to 96 (E-value = 2.5e-15) place SMu0381 in the Ribosomal_L7Ae family which is described as Ribosomal protein L7Ae/L30e/S12e/Gadd45 family (PF01248)","Mon Jan 28 16:32:56 2002","24378913","","","","","","1","","","SMU.420","896" "SMu0382","392712","395462","2751","TTGTCGAAGAAAAGATTATACGAAATTGCCAAGGAAATTGGCAAAGAAAGTAAAGAAATTGTTGAAAAGGCAAAATCATTGGGCCTAGAAGTTAAAAGCCATGCTTCAAGCGTGGAAGAAAGTGATGCTAAACGTATAGTAGAAAGTTTTACTGTCTCTGTAGAACCCAAGGCTGTTACTCCAACTTCTAAAGTTGAGAAAGAAGCCAAAGCACAAGAAGGATCTGTTGCAGCGGAACCTAAAGCAGCTGCTACAAAGCCTGCAGGGCGTCCAAGACCGCAAAATCGTAATTTTAAAGCAGAACGAGAAGCGCGTGCCAAAGCAGAGGCTGAACGTCGTCAAAATAATGGTGAACGTCGAAACCAAAATAAAGGACAGAACAATCGTCAAAAAGACAATCGTAATCATGGTTCCCAAGATCGTCGTAATGATAACCGCAATAATCGCAATCGTCAAAATGACAATCGTCGCGATAATCGTAATCATTTTCAAAATCGACAAGAAGCATCAAAATCCCAGCCGACAGGACCGCGTTTTGATTTCAAAGCACGTGCTGCAGCCTTAAAAGCAGAACAAAATGCGGAATATTCGCGTCAGAGTGAAACACGTTTTCATGAAGCTCAAGAAGCCAAACGTCAAGCCGCTCAAGCTAAAGAAAAAGCTAAGAAGCTAAATCAGAAAGAGCAGCCGACGGTTGAAGCTGCAGCAACTGCAGCGCCACAAGCTCAGCCTCAGACAGTTGAACAAGTGACACATCCAGCAGCTGTAGATACACGTCGCAAAAAACAGGCTCGCCCAGATAAATCACGTGATTTTTCACATGAGAATGAAGACGGACCAAAACAAAATAAACATAAGAAAAATCGGAATAAACAAAACCAAGTGAGAAATCAAAAAAATAGTAATTGGAATAAGAAAAATAAAAAATCTAAAAATAACCGTAATCATAATGCCAATCTGAAACCTGTGACTGAACGCAAATTCCATGAACTACCAAAGGAATTTGAGTATACAGAAGGTATGACGGTTGCTGAAATTGCAAAACGAATTAAGCGTGAGCCTGCCGAAATTGTAAAAAAACTCTTTATGATGGGAGTTATGGCAACTCAAAACCAATCTTTGGATGCTGATACGATTGAACTCCTAATGGTTGATTATGGCATTGAAGCACATCAAAAAGTGGAAGTTGATACAGCTGATATTGAACGTTTCTTCGTTGAAGATGATTATCTTAATCCGAAAAATATGGTTGAACGTGCGCCCGTTGTAACGATTATGGGGCATGTTGACCATGGTAAGACAACATTGCTTGATACATTGCGTAATTCCCGTATAGCGACAGGTGAAGCTGGAGGAATTACCCAACATATTGGGGCCTATCAAATTGAAGAAGGTGGAAAGAAAATTACTTTCCTTGATACACCCGGACATGCAGCTTTCACAAGTATGCGGGCACGCGGCGCTTCGGTAACTGATATTACCATTCTTATTGTAGCTGCTGATGATGGTGTTATGCCACAAACGATTGAAGCTATTAACCACTCCAAAGCTGCTGATGTTCCAATTATTGTTGCTATTAATAAAATTGATAAGCCGGGCGCCAATCCAGAACGTGTCATCGGTGAGTTAGCTGAGTATGGCGTTATTTCAACTGCTTGGGGCGGCGATTCTGAATTTGTTGAAATTTCAGCTAAATTCGGTCAAAATATTGAAGAACTTTTAGAAACTGTTCTTCTGGTAGCAGAAATCCAAGAACTGAAAGCTGACCCAACTGTTCGTGCTATTGGTACAGTTATCGAAGCTCGCCTTGATAAAGGAAAAGGTGCAGTAGCGACGCTTTTAGTACAACAAGGAACGCTGCATGTTCAAGATCCAATCGTTGTTGGGAACACATTTGGACGTGTGCGTGCTATGACTAATGACCTTGGACGTCGTGTTAAGGTTGCTGCTCCATCAACGCCAGTCTCTATCACTGGTTTGAATGAAGCCCCAATGGCAGGTGACCATTTTGCCGTTTATGAGGATGAAAAGGCTGCGCGTGCTGCTGGGGAAGAAAGAGCTAAACGTGCTCTGCTGAAACAACGTCAATTGACTCATCGTGTCAGTCTTGACAATCTCTTTGATACGCTCAAAGCCGGTGAGGTTAAATCTGTTAATGTTATTATCAAAGCAGATGTGCAAGGTTCCGTTGAAGCTCTTGCAGCCTCTCTTTTGAAGATTGACGTTGAAGGTGTGAAAGTTAATGTGGTCCACTCAGCTGTTGGTGCCATCAATGAATCAGATATCACCTTGGCAGAAGCTTCTAATGCTGTTATCATTGGTTTCAATGTTCGCCCAACTCCACAGGCCCGTCAGCAAGCCGAAGCAGATGAAGTTGAAATTCGTTTGCATTCCATTATTTATAAGGTAATTGAAGAAGTAGAAGATGCCATGAAAGGTATGCTTGATCCAGAGTTTGAAGAAAAAATTATTGGTGAAGCGCTTATTCGTGAGACCTTCAAAGTTTCTAAAGTGGGAACTATTGGCGGCTTCATGGTAACAAATGGTAAAATTACGCGTGATTCAAGTGCTCGTGTTATTCGTGATGGTGTGGTTGTCTTTGACGGTAAGCTCGCTAGTTTGAAACATTATAAAGATGATGTTAAAGAGGTTGGTAATGGTCAAGAAGGCGGTCTCATGATTGAAAATTACAATGACATCAAAATTGATGATACTATTGAGGCTTACATTATGGAAGAAATTAAAAGATAA","9.80","14.20","101517","MSKKRLYEIAKEIGKESKEIVEKAKSLGLEVKSHASSVEESDAKRIVESFTVSVEPKAVTPTSKVEKEAKAQEGSVAAEPKAAATKPAGRPRPQNRNFKAEREARAKAEAERRQNNGERRNQNKGQNNRQKDNRNHGSQDRRNDNRNNRNRQNDNRRDNRNHFQNRQEASKSQPTGPRFDFKARAAALKAEQNAEYSRQSETRFHEAQEAKRQAAQAKEKAKKLNQKEQPTVEAAATAAPQAQPQTVEQVTHPAAVDTRRKKQARPDKSRDFSHENEDGPKQNKHKKNRNKQNQVRNQKNSNWNKKNKKSKNNRNHNANLKPVTERKFHELPKEFEYTEGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDADTIELLMVDYGIEAHQKVEVDTADIERFFVEDDYLNPKNMVERAPVVTIMGHVDHGKTTLLDTLRNSRIATGEAGGITQHIGAYQIEEGGKKITFLDTPGHAAFTSMRARGASVTDITILIVAADDGVMPQTIEAINHSKAADVPIIVAINKIDKPGANPERVIGELAEYGVISTAWGGDSEFVEISAKFGQNIEELLETVLLVAEIQELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLHVQDPIVVGNTFGRVRAMTNDLGRRVKVAAPSTPVSITGLNEAPMAGDHFAVYEDEKAARAAGEERAKRALLKQRQLTHRVSLDNLFDTLKAGEVKSVNVIIKADVQGSVEALAASLLKIDVEGVKVNVVHSAVGAINESDITLAEASNAVIIGFNVRPTPQARQQAEADEVEIRLHSIIYKVIEEVEDAMKGMLDPEFEEKIIGEALIRETFKVSKVGTIGGFMVTNGKITRDSSARVIRDGVVVFDGKLASLKHYKDDVKEVGNGQEGGLMIENYNDIKIDDTIEAYIMEEIKR","395459","","translation initiation factor IF-2","Cytoplasm","Matches in gapped BLAST to translation initiation factor 2 sequences. Residues 1-916 are 67% similar to gi9558369 from S.agalactiae. Residues 168-916 are 74% similar to gi15902525 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0381 (0.0).","

InterPro
IPR000178
Family

Initiation factor 2
PD186100	$\"[542-645]T$	IF2_STRMU_Q8DVP9;
TIGR00487	$\"[330-916]T$	IF-2: translation initiation factor IF-2
PS01176	$\"[869-891]?$	IF2

InterPro
IPR000795
Domain

Protein synthesis factor, GTP-binding
PF00009	$\"[418-585]T$	GTP_EFTU

InterPro
IPR001806
Family

Ras GTPase
PR00449	$\"[421-442]T$ $\"[460-482]T$ $\"[518-531]T$ $\"[559-581]T$	RASTRNSFRMNG

InterPro
IPR003833
Domain

Allophanate hydrolase subunit 1
SM00796	$\"[483-651]T$	no description

InterPro
IPR004161
Domain

Translation elongation factor EFTu/EF1A, domain 2
PF03144	$\"[608-671]T$	GTP_EFTU_D2

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[418-579]T$	small_GTP: small GTP-binding protein domain

InterPro
IPR006847
Domain

Translation initiation factor IF-2, N-terminal
PF04760	$\"[1-53]T$ $\"[338-389]T$	IF2_N

InterPro
IPR010916
Domain

TonB box, N-terminal
PS00430	$\"[1-57]?$	TONB_DEPENDENT_REC_1

InterPro
IPR015760
Domain

Translation initiation factor 2 related
PTHR23115:SF41	$\"[100-681]T$ $\"[801-824]T$	TRANSLATION INITIATION FACTOR IF-2

noIPR
unintegrated

unintegrated
G3DSA:2.40.30.10	$\"[819-916]T$	no description
G3DSA:3.40.50.10050	$\"[718-797]T$	no description
G3DSA:3.40.50.300	$\"[419-582]T$	no description
PTHR23115	$\"[100-681]T$ $\"[801-824]T$	TRANSLATION FACTOR

","BeTs to 17 clades of COG0532COG name: Translation initiation factor 2 (GTPase)Functional Class: JThe phylogenetic pattern of COG0532 is aMtKYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000178 (Initiation factor 2) with a combined E-value of 9.8e-238. IPB000178A 419-457 IPB000178B 469-501 IPB000178C 502-541 IPB000178D 542-583 IPB000178E 608-660 IPB000178F 716-757 IPB000178G 792-833 IPB000178H 865-909***** IPB000795 (GTP-binding elongation factor) with a combined E-value of 4.9e-28. IPB000795A 422-437 IPB000795B 472-503 IPB000795C 507-531***** IPB000640 (Elongation factor G, C-terminus) with a combined E-value of 4.5e-19. IPB000640A 420-445 IPB000640C 469-496 IPB000640D 503-531***** PR00449 (Transforming protein P21 RAS signature) with a combined E-value of 7.4e-06. PR00449D 518-531 PR00449E 559-581","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 15:31:56 2002","Tue Jul 25 08:54:02 2006","Tue Jul 25 08:54:02 2006","Tue Jul 25 08:54:02 2006","Thu Jan 17 15:31:04 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0382 is paralogously related (blast p-value < 1e-3) to SMu1271, SMu0496, SMu0554, SMu0651, SMu1726, SMu0324, SMu1471, and SMu1744, mostly GTP-binding proteins.","Mon Jan 28 16:46:22 2002","Tue Jul 25 08:54:02 2006","pdb1G7SA Chain A, X-Ray Structure Of Translation Initiation F... 164 4e-041pdb1G7RA Chain A, X-Ray Structure Of Translation Initiation F... 159 1e-039pdb1D1NA Chain A, Solution Structure Of The Fmet-Trnafmet Bin... 132 2e-031","SMU.421","","Residues 1 to 53 (E-value = 2.1e-15) place SMu0382 in the IF2_N family which is described as Translation initiation factor IF-2, N-terminal region (PF04760)Residues 338 to 389 (E-value = 6.5e-23) place SMu0382 in the IF2_N family which is described as Translation initiation factor IF-2, N-terminal region (PF04760)Residues 418 to 585 (E-value = 4.9e-52) place SMu0382 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)Residues 608 to 671 (E-value = 3.5e-11) place SMu0382 in the GTP_EFTU_D2 family which is described as Elongation factor Tu domain 2 (PF03144)","Tue Jul 25 08:54:02 2006","24378914","","Hedegaard,J., Hauge,M., Fage-Larsen,J., Mortensen,K.K., Kilian,M., Sperling-Petersen,H.U. and Poulsen,K.Investigation of the translation-initiation factor IF2 gene, infB, as a tool to study the population structure of streptococcus agalactiaeMicrobiology 146 (Pt 7), 1661-1670 (2000)PubMed: 20340969","Moreno JM, Sorensen HP, Mortensen KK, Sperling-Petersen HU.Macromolecular mimicry in translation initiation: a model for the initiation factor IF2 on the ribosome.IUBMB Life. 2000 Dec;50(6):347-54. Review.PMID: 11327306 Caldas T, Laalami S, Richarme G.Chaperone properties of bacterial elongation factor EF-G and initiation factor IF2.J Biol Chem. 2000 Jan 14;275(2):855-60.PMID: 10625618","Mon Jan 28 16:45:10 2002","Mon Jan 28 16:45:10 2002","1","","","SMU.421","48" "SMu0383","395696","396046","351","ATGTCTAATCATCGTATTGAACGTGTTGGTATGGAAATTAAGCGCGAAGTTAATGAGATTTTGCAAAAGAAGGTACGTGACCCACGTGTTCAAGGTGTCACTATTACTGATGTCCAAATGTCAGGTGATTTATCTCTGGCAAAGGTTTACTATACTATCATGAGTGACCTTGCTTCTGATAATCAGAAAGTTCAAATAGGTCTTGAAAAGGCTAAAGGGACCATTAAACGTGAACTTGGAAAAAATTTGACCATGTATAAAATTCCCGATTTAACTTTTATCAAAGATGAATCTATTGAGTATGGTAATAAGATTGACCAAATGCTGCGGGATTTAGAAAAAAGAAATTAA","10.00","3.23","13398","MSNHRIERVGMEIKREVNEILQKKVRDPRVQGVTITDVQMSGDLSLAKVYYTIMSDLASDNQKVQIGLEKAKGTIKRELGKNLTMYKIPDLTFIKDESIEYGNKIDQMLRDLEKRN","396043","","ribosome binding factor A","Cytoplasm","Matches in gapped BLAST to ribosome binding factor A sequences. Residues 1-116 are 84% similar to gi15675570 from S.pyogenes. Residues 1-114 are 86% similar to gi15902526 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0382 (4e-51).","

InterPro
IPR000238
Family

Ribosome-binding factor A
PD007327	$\"[7-96]T$	Rib_bind_factA
PF02033	$\"[5-109]T$	RBFA
TIGR00082	$\"[1-115]T$	rbfA
PS01319	$\"[75-96]T$	RBFA

InterPro
IPR009019
Domain

KH, prokaryotic type
G3DSA:3.30.300.20	$\"[1-115]T$	KH_prok

noIPR
unintegrated

unintegrated
SSF89919	$\"[1-104]T$	SSF89919

","BeTs to 12 clades of COG0858COG name: Ribosome-binding factor AFunctional Class: JThe phylogenetic pattern of COG0858 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000238 (Ribosome-binding factor A) with a combined E-value of 5.9e-44. IPB000238A 5-28 IPB000238B 34-48 IPB000238C 67-109","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 29 16:04:10 2002","Tue Jan 29 15:58:46 2002","Thu Jul 6 15:14:30 2006","Wed Apr 10 13:11:51 2002","Tue Jan 29 15:58:46 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0383 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 16:04:10 2002","","No significant hits to the NCBI PDB database.","SMU.422","","Residues 5 to 109 (E-value = 4.9e-32) place SMu0383 in the RBFA family which is described as Ribosome-binding factor A (PF02033)","Tue Jan 29 15:58:46 2002","24378915","","","Bae W, Xia B, Inouye M, Severinov K.Escherichia coli CspA-family RNA chaperones are transcription antiterminators.Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7784-9. PMID: 10884409Dammel,C.S. and Noller,H.F.Suppression of a cold-sensitive mutation in 16S rRNA byoverexpression of a novel ribosome-binding factor, RbfAGenes Dev. 9 (5), 626-637 (1995)PubMed: 7535280Bylund GO, Wipemo LC, Lundberg LA, Wikstrom PM.RimM and RbfA are essential for efficient processing of 16S rRNA in Escherichia coli.J Bacteriol. 1998 Jan;180(1):73-82.PMID: 9422595 Jones PG, Inouye M.RbfA, a 30S ribosomal binding factor, is a cold-shock protein whose absence triggers the cold-shock response.Mol Microbiol. 1996 Sep;21(6):1207-18.PMID: 8898389","","Thu Oct 24 10:33:30 2002","1","","","SMU.422","767" "SMu0384","396531","396761","231","ATGAATACACAAGCATTTGAACAATTTAACGTAATGGATAATGAAGCACTTTCAACTGTTGAGGGTGGTGGTATGATTAGATGTGCACTTGGCACAGCTGGTTCTGCAGGTTTAGGATTTGTAGGGGGTATGGGAGCTGGTACAGTTACTCTCCCAGTCGTTGGTACAGTATCTGGAGCGGCTTTAGGAGGCTGGTCTGGAGCAGCTGTAGGTGCTGCTACTTTTTGTTGA","3.90","-3.12","7212","MNTQAFEQFNVMDNEALSTVEGGGMIRCALGTAGSAGLGFVGGMGAGTVTLPVVGTVSGAALGGWSGAAVGAATFC","396758","Kreth et al., 2005, state that this mutacin-like gene is regulated by the competence system.","possible bacteriocin","Extracellular","One very weak hit in gapped BLAST to gi11095283, a predicted bovicin 255 peptide precursor from Streptococcus sp. Residues 1-28 are 71% similar to this sequence.SMu0384 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010133
Domain

Bacteriocin-type signal sequence
TIGR01847	$\"[9-23]T$	bacteriocin_sig: bacteriocin-type signal se

noIPR
unintegrated

unintegrated
tmhmm	$\"[28-46]?$ $\"[52-72]?$	transmembrane_regions

InterPro
IPR005650
Family

Penicillinase repressor
PD008194	$\"[12-109]T$	Prok_trans_reg
PF03965	$\"[4-118]T$	Pencillinase_R

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-79]T$	Wing_hlx_DNA_bd

InterPro
IPR014071
Family

Copper transport repressor CopY/TcrY
TIGR02698	$\"[3-132]T$	CopY_TcrY

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-122]T$	SSF46785

InterPro
IPR000150
Family

Cof protein
PS01229	$\"[628-650]?$	COF_2

InterPro
IPR001756
Family

ATPase, P-type copper-transporter
PR00943	$\"[147-166]T$ $\"[200-219]T$ $\"[220-238]T$ $\"[353-367]T$ $\"[414-429]T$ $\"[605-622]T$	CUATPASE

InterPro
IPR001757
Family

ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119	$\"[280-294]T$ $\"[431-445]T$ $\"[553-564]T$ $\"[575-585]T$ $\"[628-647]T$ $\"[651-663]T$	CATATPASE
PTHR11939	$\"[1-737]T$	ATPase_P
TIGR01494	$\"[202-723]T$	ATPase_P-type
PS00154	$\"[433-439]?$	ATPASE_E1_E2

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[427-651]T$	Hydrolase

InterPro
IPR006121
Domain

Heavy metal transport/detoxification protein
PF00403	$\"[5-69]T$	HMA
PS01047	$\"[8-37]T$	HMA_1
PS50846	$\"[3-69]T$	HMA_2
SSF55008	$\"[1-72]T$	HeavyMe_transpt

InterPro
IPR006403
Family

ATPase, P type cation/copper-transporter
TIGR01511	$\"[143-738]T$	ATPase-IB1_Cu

InterPro
IPR006416
Family

Heavy metal translocating P-type ATPase
TIGR01525	$\"[162-737]T$	ATPase-IB_hvy

InterPro
IPR008250
Domain

E1-E2 ATPase-associated region
PF00122	$\"[202-423]T$	E1-E2_ATPase

noIPR
unintegrated

unintegrated
G3DSA:2.70.150.10	$\"[172-310]T$	G3DSA:2.70.150.10
G3DSA:3.30.70.100	$\"[3-79]T$	G3DSA:3.30.70.100
G3DSA:3.40.50.1000	$\"[548-672]T$	G3DSA:3.40.50.1000
PTHR11939:SF39	$\"[1-737]T$	PTHR11939:SF39
SSF56784	$\"[418-673]T$	SSF56784
SSF81653	$\"[232-330]T$	SSF81653
SSF81665	$\"[162-717]T$	SSF81665

InterPro
IPR006121
Domain

Heavy metal transport/detoxification protein
PF00403	$\"[4-65]T$	HMA
PS50846	$\"[2-65]T$	HMA_2
SSF55008	$\"[1-63]T$	HeavyMe_transpt

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.100	$\"[1-64]T$	G3DSA:3.30.70.100
PTHR22814	$\"[12-57]T$	PTHR22814

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[6-268]T$	Cof-subfamily
PS01228	$\"[6-17]T$	COF_1
PS01229	$\"[222-244]T$	COF_2

InterPro
IPR001757
Family

ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119	$\"[8-22]T$ $\"[222-241]T$ $\"[245-257]T$	CATATPASE

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[6-241]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[7-268]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[3-272]T$	G3DSA:3.40.50.1000
PTHR10000	$\"[191-253]T$	PTHR10000
SSF56784	$\"[3-273]T$	SSF56784

noIPR
unintegrated

unintegrated
PD103083	$\"[18-155]T$	PD103083

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[122-164]T$	ABC_transporter
PF00005	$\"[29-197]T$	ABC_tran
PS00211	$\"[122-136]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-221]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-204]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-212]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-245]T$	PTHR19222
PTHR19222:SF16	$\"[4-245]T$	PTHR19222:SF16
SSF52540	$\"[3-245]T$	SSF52540

","BeTs to 9 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.1e-38. IPB001140A 18-64 IPB001140B 119-157 IPB001140C 174-203","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 09:55:15 2002","Thu Sep 28 10:55:07 2006","Thu Sep 28 10:55:07 2006","Fri Apr 26 09:21:15 2002","Fri Feb 1 09:43:32 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0390 is paralogously related (blast p-value < 1e-3) to SMu0596, SMu1920, SMu0216, SMu0884, SMu1003, SMu0944, SMu1079, SMu0335, SMu1410, SMu1518, SMu0594, SMu0971, SMu0517, SMu1023, SMu0731, SMu0786, SMu0418, SMu1762, SMu1950, SMu1380, SMu0374, SMu1246, SMu1231, SMu0916, SMu1751, SMu0258, SMu1949, SMu1649, SMu1068, SMu0849, SMu1210, SMu0950, SMu0218, SMu1428, SMu0976, SMu1001, SMu1093, SMu1517, SMu0164, SMu1710, SMu1811, SMu1064, SMu0476, SMu0805, SMu0907, SMu1545, SMu1288, SMu0234, SMu0987, SMu0475, SMu0825, SMu0235, SMu0823, SMu1036, SMu1306, SMu1757, SMu1316, SMu1037, SMu0836, SMu0986, SMu1959, SMu1050, SMu0837, SMu1724, SMu0666, SMu0024, SMu0824, SMu1065, SMu0752, SMu0224, SMu0729, SMu1202, and SMu1686, all with ATP-binding capabilities.","Fri Apr 26 09:21:15 2002","Thu Sep 28 10:55:07 2006","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 112 5e-026pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 84 2e-017","SMU.431","","Residues 29 to 197 (E-value = 1.1e-58) place SMu0390 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Feb 1 09:43:32 2002","24378922","","","","Tue Oct 29 09:55:15 2002","","1","","","SMU.431","" "SMu0391","402924","403781","858","ATGTTGGCTTTGGTTAAACGTAATTGTTTGCTCTATTTCCGCAATCGCAGCGGTGTGGTTTTCTCACTGCTGGGTGCTCTGATTTCTTTTATTCTTTATTTGGTATTTTTAAAGGATAATATTGAATCTTCTTGGTCTCAAATTGACAATACCAATCAACTCTTAGATACATGGCTTATTGGTGGAACTTTGGCTATTACGGGGATTACAACAACCTTATCTAACCTTTCACAATGGACAAAAGACAAAGAAAGTCATGTCCGTCAAGATCTTTTGATTACAGATTTAGGTTATTGGCCTCTTTCTTTAAGTTATATTATCAGCGCTGCTCTTGTTGGTTTTATCATGCAGGCTATTATGCTGACGATTATGGGAACGTATTTCTATTTTACTGATAAGGTAACACTTTCTTGGACTGTTCTTTTGCAGCTTATCTTTATCATGATTTTAAATACACTGATTTCAACCATCATTAATGCTCTGATCGTGAATCGCATTCAATCGGTTGATAATCTTGGGAAACTAGCTACTATTTTTGGAGCTGCCTCGGGATTTCTTGTAGGTACCTATGTTCCAATCGGTGCCCTGCCAGATACAGCGCAAACCATCATGAAGCTGACTCCGGGTGCTTATATCGCTTCTTTATTTAGACAAACCTTAATGTCAGATACTCTTAAAGACAATTTTAGTCAAGCAAATGCTAGAGAGCATTTTGAAAAAATGATGGGGATTCGCTTGAATTGGCAAAATTTATTGACAAATACTGATACTTACTATATAGTGATAGGTATCTTAGTGGCTGGTGTTCTCATCTTTTGTTTACAAAATGCTTTGCGAAAATACCAAGCCCTCATTTAG","9.20","3.37","31907","MLALVKRNCLLYFRNRSGVVFSLLGALISFILYLVFLKDNIESSWSQIDNTNQLLDTWLIGGTLAITGITTTLSNLSQWTKDKESHVRQDLLITDLGYWPLSLSYIISAALVGFIMQAIMLTIMGTYFYFTDKVTLSWTVLLQLIFIMILNTLISTIINALIVNRIQSVDNLGKLATIFGAASGFLVGTYVPIGALPDTAQTIMKLTPGAYIASLFRQTLMSDTLKDNFSQANAREHFEKMMGIRLNWQNLLTNTDTYYIVIGILVAGVLIFCLQNALRKYQALI","403778","For other components see SMu0390 (NBD1).","ABC transporter, permease and solute binding protein","Membrane, Cytoplasm","Matches in gapped BLAST to ABC transporters, CylB-like. Residues 4-255 are 28% similar to gi16803027 from L.monocytogenes. Residues 1-233 are 25% similar to gi4886776 from S.agalactiae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0668 (8e-16).","

InterPro
IPR013525
Domain

ABC-2 type transporter
PF01061	$\"[1-221]T$	ABC2_membrane

","BeTs to 4 clades of COG0842COG name: Predicted integral membrane proteinFunctional Class: SThe phylogenetic pattern of COG0842 is A-TK--VcEBR-UJ-------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:03:47 2002","Thu Sep 28 10:58:43 2006","Thu Sep 28 10:58:43 2006","Fri Apr 26 09:21:45 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0391 is paralogously related (blast p-value < 1e-3) to SMu1409, a conserved hypothetical protein.","Fri Feb 1 10:24:51 2002","","No significant hits to the NCBI PDB database.","SMU.432","","No significant hits to the Pfam 11.0 database","Fri Feb 1 10:18:58 2002","24378923","","","Spellerberg,B., Martin,S., Brandt,C. and Lutticken,R.The cyl genes of streptococcus agalactiae are involved in theproduction of pigmentFEMS Microbiol. Lett. 188 (2), 125-128 (2000)PubMed: 10913694Shankar,N., Baghdayan,A.S. and Gilmore,M.S.Modulation of virulence within a pathogenicity island invancomycin-resistant Enterococcus faecalisNature 417 (6890), 746-750 (2002)PubMed: 12066186Pritzlaff,C.A., Chang,J.C., Kuo,S.P., Tamura,G.S., Rubens,C.E. andNizet,V.Genetic basis for the beta-haemolytic/cytolytic activity of group B StreptococcusMol. Microbiol. 39 (2), 236-247 (2001)PubMed: 11136446","","Thu Oct 10 13:15:23 2002","1","","","SMU.432","" "SMu0392","403795","404253","459","GTGGTAGAAAGTCAATTCGAACAGGATTCACAAATTTCGACTGACAGCCCCCTTGTCTTAGTCAAGGCGGCGGAAAAGACAAGTGCTATTCAACAGTTGTTGGATTATATCAGCAACTATCAGATGATATCTAGTAATTCTATTCCTATCAAAAGTATGGATAAAATTATGATGTTGAAGCTAGATGACATTATTTTAGTTGATGTAAATCAGACGACACTTAAAATTTATACTTTAACGGGTGTATTTACCACGACTGAGACCTTGGTTCATTTTGCCAATCGTCTGAATAAATCTAACTTTATTCAAATTTCCAAACATGCCCTGATTAATCTTGACCATCTGGAATCTCTGTCAGACAGTTTTTCGGGGAACATGATGGCAAAGTTAAGCAGTAATATCAAATCAAGCGTCAGTCGCAAGTATGTTAAAGGTTTAATGACTCAGCTGGGCATTTAG","7.80","0.71","16948","MVESQFEQDSQISTDSPLVLVKAAEKTSAIQQLLDYISNYQMISSNSIPIKSMDKIMMLKLDDIILVDVNQTTLKIYTLTGVFTTTETLVHFANRLNKSNFIQISKHALINLDHLESLSDSFSGNMMAKLSSNIKSSVSRKYVKGLMTQLGI","404250","","transcriptional regulator","Cytoplasm, Membrane","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1016 (1e-07).","

InterPro
IPR007492
Domain

LytTr DNA-binding region
PF04397	$\"[54-151]T$	LytTR
PS50930	$\"[48-152]T$	HTH_LYTTR

noIPR
unintegrated

unintegrated
signalp	$\"[1-78]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[35-54]?$ $\"[64-84]?$ $\"[94-114]?$	transmembrane_regions

InterPro
IPR003764
Family

N-acetylglucosamine-6-phosphate deacetylase
TIGR00221	$\"[9-386]T$	nagA

InterPro
IPR006680
Domain

Amidohydrolase 1
PF01979	$\"[58-373]T$	Amidohydro_1

InterPro
IPR011059
Domain

Metal-dependent hydrolase, composite
SSF51338	$\"[3-390]T$	Metalo_hydrolase

InterPro
IPR011550
Domain

Amidohydrolase-like
PD001248	$\"[333-371]T$	Amidohydro_like

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.140	$\"[62-358]T$	G3DSA:3.20.20.140
PTHR11113	$\"[49-390]T$	PTHR11113
SSF51556	$\"[62-359]T$	SSF51556

","BeTs to 5 clades of COG1820COG name: N-acetylglucosamine-6-phosphate deacetylaseFunctional Class:� GThe phylogenetic pattern of COG1820 is ------v-Ebrh----o----Number of proteins in this genome belonging to this COG is 1","***** IPB003764 (N-acetylglucosamine-6-phosphate deacetylase) with a combined E-value of 2e-28. IPB003764A 222-236 IPB003764B 251-267 IPB003764C 275-287 IPB003764D 343-385","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 11:52:51 2002","Tue Feb 5 11:48:07 2002","Tue Feb 5 11:52:51 2002","Tue Feb 5 11:48:07 2002","Tue Feb 5 11:48:07 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0394 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 11:52:51 2002","","No significant hits to the NCBI PDB database.","SMU.435","","Residues 58 to 373 (E-value = 3.3e-08) place SMu0394 in the Amidohydro_1 family which is described as Amidohydrolase family (PF01979)","Tue Feb 5 11:48:07 2002","24378926","","Homer KA, Patel R, Beighton D.Effects of N-acetylglucosamine on carbohydrate fermentation by Streptococcus mutans NCTC 10449 and Streptococcus sobrinus SL-1.Infect Immun. 1993 Jan;61(1):295-302.PMID: 8418050","Ferreira FM, Mendoza-Hernandez G, Calcagno ML, Minauro F, Delboni LF, Oliva G.Crystallization and preliminary crystallographic analysis of N-acetylglucosamine 6-phosphate deacetylase from Escherichia coli.Acta Crystallogr D Biol Crystallogr. 2000 May;56 ( Pt 5):670-2.PMID: 10771446 ","Tue Feb 5 11:56:39 2002","Tue Feb 5 11:56:39 2002","1","","","SMU.435","247" "SMu0395","407086","406250","837","TTGGTAACGGAGTTTTCTTTAGACATTCTTCTAAAGATTATTAAGCTCGCTCGTTCAACCTATTATTACCACTTAAAGCAGCTAGATAAAAGCAATAAAGATCATGCTATTAAAGCTGAAATTCAAGCTATTTTTACTGAGCACAAAGGAAATTATGGTTATCGTCGAATGACTCTTGAATTGAGAAATCGTGGCTTCTTGGTAAATCATAAAAAGGTTCAACGTCTAATGAAAGTTCTTGGTTTGGAGGCTCGTATTCGTCGCAAACGGAAGTATTCTTCCTACCAAGGAGAGGTGGGCAAGAAAGCAGACAACCTTATTCAACGCCAATTTGAAGCATCAAAACCAATGGAAAAGTGCTACACAGATGTGACAGAATTTGCCATTCCAGCAAGCGGTCAAAAGCTCTATTTGTCACCAGTTTTAGATGGTTTCAACAGTGAAATTATTGCTTATAACCTTTCTACGTCACCGAACTTGATACAAGTGAAAGCTATGCTAGAACAGGCTTTCACAGAGAAACATTACACAAATACTATTCTTCATAGTGACCAAGGCTGGCAATACCAGCATGATTTTTATCATCAATTTTTAGAGAACAAGGGGATTCAGCCGTCCATGTCACGTAAAGGAAACAGCCCAGATAATGGCATGATGGAATCTTTCTTTGGCATTTTGAAATCCGAAATGTTTTACGGTTATGAGAAGACATTTAAGTCACTTAAGCAATTGGAACAAGCTATTGTAGACTATATTGATTATTACAACAACAAACGTATTAAGGTAAAACTAAAAGGACTTAGTCCTGTACAGTACAGAACGAAATCCTTTACTTAA","10.40","17.88","32568","MVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGNYGYRRMTLELRNRGFLVNHKKVQRLMKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQFEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIAYNLSTSPNLIQVKAMLEQAFTEKHYTNTILHSDQGWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT","406253","","transposase, IS3-Spn1","Cytoplasm","This sequence was previously published in GenBank as gi|3873218, a predicted transposase. Residues 204-278 are 97% similar to residues 1-75 of gi|3873218. Furthermore, residues 2-277 are 84% similar to gi|8163693, a predicted IS3-Spn1 transposase.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (1e-122).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[112-274]T$	rve
PS50994	$\"[112-277]T$	INTEGRASE

noIPR
unintegrated

unintegrated
PD688335	$\"[35-76]T$	Q8DVC7_STRMU_Q8DVC7;
G3DSA:3.30.420.10	$\"[137-278]T$	no description
signalp	$\"[1-19]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","Thu Nov 29 17:53:01 2001","Thu Nov 29 17:53:01 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 12:03:54 2002","Tue Feb 5 12:03:54 2002","Tue Feb 5 12:03:54 2002","Tue Feb 5 12:01:26 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0395 is paralogously related (blast p-value < 1e-3) to SMu1719, SMu1283, SMu0695, SMu1258, SMu0514, SMu0798, SMu1250, SMu0934, SMu0537, SMu1237, SMu1236, and SMu1235, transposase-related..","Tue Feb 5 12:05:08 2002","","No significant hits to the NCBI PDB database.","SMU.436c","Thu Nov 29 17:53:01 2001","Residues 112 to 274 (E-value = 1.2e-40) place SMu0395 in the rve family which is described as Integrase core domain (PF00665)","Tue Feb 5 12:01:26 2002","24378927","","","","Tue Feb 5 12:03:54 2002","","1","","","SMU.436c","" "SMu0396","407656","407081","576","ATGAACTGCACCCCAAAAGTTAGACAGAAAAAATCTAACTTTTGGGGTGTTTTTATTATGAAATTGACTTATGAAGATAAAGTTCTCATCTATGAACTGAAAAACCAAGGGTATAGCTTAGAGCAGCTTTCAAATAAATTTGGGATAAAAATTTCTAATCTTAGCTACATGATTAAATTGATTGATCATTACGGAATAGAGATCGTCAAAAAAGGAAAGAATCGTTACTATTCTCCTGAACTAAAACAAGAAATCATTGATAAAGTTCTTCTTGAAGGTCGTTCACAAATAAGGGTGTCTCTAGATTATGCTCTTCCAAGTCATGGAATGTTGCCTAATTGGATAGCACAATACAAGAAAAATAGGTATACTATTGTTGAGAAAACAAGAGGGAGACCACCTAAAATGGGACGTAAGCCAAAAAAGAAAATCGGAAGAAATGACAGAGCTAGAGCAACTTCAGAAAGAATTAGAATATCTGAGAGCGGAGAATGCTGTTCTAAAAAAGTTGAGAGAACTCCGATTGAGGGAAGAAAAAGAGCAAGAAGAAAAACGGAAATTGTCCGAGGATTGGTA","11.00","26.33","22493","MNCTPKVRQKKSNFWGVFIMKLTYEDKVLIYELKNQGYSLEQLSNKFGIKISNLSYMIKLIDHYGIEIVKKGKNRYYSPELKQEIIDKVLLEGRSQIRVSLDYALPSHGMLPNWIAQYKKNRYTIVEKTRGRPPKMGRKPKKKIGRNDRARATSERIRISESGECCSKKVERTPIEGRKRARRKTEIVRGLV","407083","Dragana:2. SMU.437 has a frame shift and it should be resequenced. This ORF is part of an IS element (IS861) and there are 5 more copies of this IS around the genome. You can check ORFs SMU.436, 437 and compare them to SMU.565, 566 (this is another copy of the same IS).","transposase, IS861-associated","Cytoplasm, Extracellular","Matches in gapped BLAST to degenerate transposases. Residues 1-89 are 86% similar to gi15903384 from S.pneumoniae. Residues 20-127 are 62% similar to gi15674401 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1526 (1e-36).","

InterPro
IPR002514
Family

Transposase IS3/IS911
PF01527	$\"[74-120]T$	Transposase_8

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","Thu Nov 29 18:28:03 2001","Thu Nov 29 18:37:06 2001","Thu Nov 29 18:37:06 2001","Thu Nov 29 18:37:06 2001","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","Thu Nov 29 18:37:06 2001","Thu Nov 29 18:37:06 2001","","Tue Feb 5 12:06:12 2002","Tue Sep 26 13:03:17 2006","Tue Sep 26 13:03:17 2006","Mon Dec 3 12:56:35 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0396 is paralogously related (blast p-value < 1e-3) to SMu1720, SMu1284, SMu1257, SMu0694, and SMu0515.","Tue Feb 5 12:11:55 2002","","No significant hits to the NCBI PDB database.","SMU.437c","Thu Nov 29 18:28:03 2001","No significant hits to the Pfam 11.0 database","Mon Dec 3 12:56:35 2001","","","","","","","1","","","SMU.437c","" "SMu0397","412040","407739","4302","ATGTATAAAGCTGGTATTGATGTTGGTTCAACAACAGTTAAGGTCGTTGTCTTTGACCAAGATTATCATTTAATCTTTTCACGTTATGAACGCCATTTTTCAGACGTAAAAGCGGCAACTATCAAGATAATTCAAGAAGCCATATCTAAAATCGGTAATCAGGAGGTCTCCATTGCCATCACTGGCTCTGGAGGTATGGGACTGTCTGATGCGGCTGAAATTCCTTTTGTCCAAGAAGTTATCGCAGCAACTACCACCGTGGAAAAATTCATTCCACAAACAGATGTGGTTATTGAATTGGGCGGTGAAGATGCCAAAATGACCTTCTTTGGGGATGCCCTCGAACAACGCATGAACGGAACTTGTGCTGGTGGTACAGGAGCTTTCATTGACCAAATGGCAGAATTGCTAAAAACAGATGCTAACGGTGTTAATGAATTGGCTAAAGAGTATGAAACCATCTATCCGATTGCCAGCCGTTGTGGTGTTTTTGCCAAAACAGATGTCCAACCGCTGATTAATGAAGGAGCCCGTAAGGAAGACATTGCGGCTTCCATCTTTCAGGCGGTCGTCAATCAAACTATTGCTGGACTAGCTTCTGGTCGTAAGATTACAGGTAATATTGCCTTTTTAGGCGGACCGCTCTTTTTCATGAGTGAATTGCGCCAACGCTTCATTGAAACTCTGGATATCAAGTCTGAGAATGTTATTTTCCCAAAAAATCCTCAACTATTTGTTGCTATGGGAGCAGCCCTTGATGAAAATCAAAGCCAATTAAAATTATCACAAATTATTGATAACCTTAACAATAATAGTTCTGATTCTCTTGTACCTAAAAGCACTTTAGATGTTCTCTTTAAAGACCAAGATGAGTTAGATACTTGGCGTCAACGCCACAATGAAGCTAGTGCTCAGCGTAAGGACATCTCTACTGCTTCTGGTCCAGTCTTCTTAGGAATTGATGCTGGTTCTACCACTTCAAAAGTTATTTTGACTGATCCTAATGGTAATATTTTATTCGAGCATTACGGCAACAATTTAGGGCAACCCTTAGAAAATATCATTGTCATCCTCAAGCAAGTATACCAAGAATTACCAAGTACTGCTTTTATAGCCAATTCTTGTGTTACTGGTTACGGAGAACACCTTATCAAGGCTGCTCTGCGAGTTGATAATGGCGAAGTTGAGACCGTTGCTCACTTCAAAGCTGCCAATTATTTTAATCCTGGTGTTGATTTCATTTTAGATATTGGTGGTCAGGATATGAAAGCCATGTCTATTCAAGATGGGGCGCTCTCTAGCATCCAGCTCAACGAGGCCTGCTCGTCTGGGTGCGGTTCTTTCATTGAAACCTTTGCCAAATCTCTCAAATACGATGTCAAAGATTTTGCTAAAGCAGCCCTTTTGGCTAAACATCCTGTGGATTTGGGGTCAAAATGCACTGTCTTCATGAATTCCAAGGTCAAACAGGTACAAAAAGAAGGAGCCACTGTCGCTGACATCTCAGCAGGACTTTCTTATTCTGTTATCAAAAACGCCCTTTACAAGGTTATCAAGGTCAAACGGCCAGAAGATTTGGGACAAAAGATTGTCGTTCAAGGCGGTACTTTTTACAATGAAGCTGTTCTTCGAGCCTTTGAATTGGTCTCAGGTCGTGAAGTCGTTCGTCCCAATATTGCTGGACTTATGGGAGCCTACGGCTGTGCCCTTATTGCCCAAGAAAAGTATGAAGACCATGCTCAGCCATCCAAACTCATGCAATTAGAAGAATTAACAGCATTCAAGGCAGAAAAAGAATTCACTCGATGTGGTCTTTGTGAAAATAATTGTTCCTTGACCGTTACTATCTTTAACGATGGCTCTAAATTTGTGACGGGTAATCGCTGTGAACGCGGTGCCGAAAAAGTCACCAAAATTAAATTTGACCGCAGCAAGCAAAAAGAAAATTTGGTTGATTATAAATACAAGAAGCTTTTTAAATTCAAGGCCTTATCTAAACGCGATGCTAAGCATGGTGTGATGGGAATCCCTCGCGTTCTCAATCTATATGAAAATTATCCTCTATGGCATACTATCTTGACCGACCTAGGATTTCGTGTTCAAATTTCACCAAAATCTGATAAAAAACTTTATCAAAAGGGAATCGAAACCATTCCAAGTGATACCGTTTGTTACCCTGCTAAAATGGTACACGGTCATATTCAAGCTCTTATTGATAAAAAAGTAGAAGCCATTTTCTATCCAAGTGTCATTTACGAACAAGTCGAAAATAAACAAGCACCTAATCATTACAACTGCCCTATTGTCCAAGGTTATCCAGAACTGATTGAAAAAAATATGGATCCCATTCGTAATAAAGAGGTCAAATATTTCCATCCCTTTGTTAATTTAGCTGATCCAGCAAGTGTTGTCCAAGCACTTGTCAAAGCTTTTGCAGATTATGATGATATAACGAACGAGCAGATTCACAAAGCCGTTGAACATGGCTTTCAAGCTTTAACGGATTTCAAAACTGACTTACAAACCAAAGCAGATGAACTCTTAGCACACTTGGCAATGAACAATGAAAAAGCTATTGTATTGTCAGGTCGTCCTTATCATCTTGATCCAGAAATCAATCATGGTATCGCTAATATCATTACTCAGGAAGGTTTCCATGTGCTGACTGAAGATATGGTATCGGGTCTTGAAGAGGTTGATGGCTTGCGTGTTGTCAATCAATGGGTCTACCATTCTCGACTTTACGCCGCTGCCAAGGTCGTTTCTAAAAATCCTAATTTGGAACTGGTTCAGCTTAATAGTTTTGGTTGTGGTCTTGATGCTGTCACAACAGATCAAGTTGAAGAAATCATGCGCGGTCATAACAAACTCTACACCGTTCTTAAGATTGACGAAGGCAGCAATATGGGAGCTATTCGTATCCGTCTGCGTTCGCTTAAGGCAGCCGTGAAAGAACGTGACCAAAAAGTCAAAAAGGCTAAGCTTGATCACATTTTCAACCAAACACCACAATTTCCACAGAATCTAGAAAATGAAGAAAGCAAACAAAGGCCTGTCTTCACCAAGGACATGAAAAAGACCCATACCCTGCTCATGCCAATGCTATCGCCTATTCATCAAAATGGTCTCATTGAAGAAGCCTTCAAGCAATCAGGTTACAATGTTGTCATATTGCCAGCCATGGATCGCAAGGCAGTTGACGTAGGATTAAAATTTGTCCACAATGATGCCTGCTATCCTGCTATTATCACTATTGGTCAATTAGTTGAAGCCCTACAAAGCGGTCAATATGATCTCAACAATACCAGTGTCATGATGACGCAAACTGGCGGCGGTTGTCGAGCAACCAATTATATTCCGCTTTTACGCAAAGCTCTTAAGGACGCTGGTTTTTCACAAATTCCTGTCGTCTCTATTTCTATGGGAAATCAAGGAACTGAAGAAACACCGGGATGGAAACTTAACTACTCTTTTGTCAAACGTCTGCTTATCAGTGTGCTCTACGGCGATCTTTTTGAACGCTTACTCTACCGCGTGCGTCCTTACGAGTCTGTTAAAGGCTCAGCTAATACTCTTTATGACAAATGGTTAGAAATTGCTCGTAAAAATGTCAAATCAGGTTCTTACTTTGAATTCAATCGTAATATGAAACGTATTATTCGTGAGTTTGACAAGCTGGAAACAGTTAATTTTGGACAAAAACCACGCGTTGGTGTTGTCGGAGAAATTTTGGTTAAATATGCTCCAACAGCCAACAATGACATCGTTGGTATTATTGAAAGAGAGGGGGGTGAAGCTGTTGTTCCAGATTTGATTGGTTTTATGAATTATTCACTGTTTAATCAAATCTGGAAAGCTGATGAACTTAATATGAGTCAAAAAACAAAACGCTTGGCTAAACTAGGTATTGATGCTATTAACCTCCTTGAAAAGCCAATGAATAAAGCACTTGAAAAATCGGAACGTTTTGAAGGCATTGAGTCTATTTATAACATTGCTGATAGTGCTTCCAAGATTATCTCTATTGGTAATCATACAGGTGAGGGTTGGTTCCTGACTGGTGAAATGATTGAACTGCTTAATAATGATGTTAAAAACATCGTCTGTCTGCAGCCATTTGGCTGTCTGCCCAACCATATCGTTGGTAAGGGAATGGTAAAAGAACTTCGCAGGCAGTATAAAGGGGCTAATATCGCTCCTATTGACTACGACCCAGGTTCTTCAGAAGTCAATCAGCTCAACCGTATTCGTCTTATGATGACAACTGCTAAGAAAATGCAAAAGACCAAAGTCAATGCTTAG","7.20","3.05","159325","MYKAGIDVGSTTVKVVVFDQDYHLIFSRYERHFSDVKAATIKIIQEAISKIGNQEVSIAITGSGGMGLSDAAEIPFVQEVIAATTTVEKFIPQTDVVIELGGEDAKMTFFGDALEQRMNGTCAGGTGAFIDQMAELLKTDANGVNELAKEYETIYPIASRCGVFAKTDVQPLINEGARKEDIAASIFQAVVNQTIAGLASGRKITGNIAFLGGPLFFMSELRQRFIETLDIKSENVIFPKNPQLFVAMGAALDENQSQLKLSQIIDNLNNNSSDSLVPKSTLDVLFKDQDELDTWRQRHNEASAQRKDISTASGPVFLGIDAGSTTSKVILTDPNGNILFEHYGNNLGQPLENIIVILKQVYQELPSTAFIANSCVTGYGEHLIKAALRVDNGEVETVAHFKAANYFNPGVDFILDIGGQDMKAMSIQDGALSSIQLNEACSSGCGSFIETFAKSLKYDVKDFAKAALLAKHPVDLGSKCTVFMNSKVKQVQKEGATVADISAGLSYSVIKNALYKVIKVKRPEDLGQKIVVQGGTFYNEAVLRAFELVSGREVVRPNIAGLMGAYGCALIAQEKYEDHAQPSKLMQLEELTAFKAEKEFTRCGLCENNCSLTVTIFNDGSKFVTGNRCERGAEKVTKIKFDRSKQKENLVDYKYKKLFKFKALSKRDAKHGVMGIPRVLNLYENYPLWHTILTDLGFRVQISPKSDKKLYQKGIETIPSDTVCYPAKMVHGHIQALIDKKVEAIFYPSVIYEQVENKQAPNHYNCPIVQGYPELIEKNMDPIRNKEVKYFHPFVNLADPASVVQALVKAFADYDDITNEQIHKAVEHGFQALTDFKTDLQTKADELLAHLAMNNEKAIVLSGRPYHLDPEINHGIANIITQEGFHVLTEDMVSGLEEVDGLRVVNQWVYHSRLYAAAKVVSKNPNLELVQLNSFGCGLDAVTTDQVEEIMRGHNKLYTVLKIDEGSNMGAIRIRLRSLKAAVKERDQKVKKAKLDHIFNQTPQFPQNLENEESKQRPVFTKDMKKTHTLLMPMLSPIHQNGLIEEAFKQSGYNVVILPAMDRKAVDVGLKFVHNDACYPAIITIGQLVEALQSGQYDLNNTSVMMTQTGGGCRATNYIPLLRKALKDAGFSQIPVVSISMGNQGTEETPGWKLNYSFVKRLLISVLYGDLFERLLYRVRPYESVKGSANTLYDKWLEIARKNVKSGSYFEFNRNMKRIIREFDKLETVNFGQKPRVGVVGEILVKYAPTANNDIVGIIEREGGEAVVPDLIGFMNYSLFNQIWKADELNMSQKTKRLAKLGIDAINLLEKPMNKALEKSERFEGIESIYNIADSASKIISIGNHTGEGWFLTGEMIELLNNDVKNIVCLQPFGCLPNHIVGKGMVKELRRQYKGANIAPIDYDPGSSEVNQLNRIRLMMTTAKKMQKTKVNA","407742","","(R)-2-hydroxyglutaryl-CoA dehydratase activator-related protein","Cytoplasm","Matches in gapped BLAST to 2-hydroxyglutaryl-CoA dehydratase activator-related proteins. Residues 1-1418 are 70% similar to gi|15674220 from L.lactis. Residues 5-1418 are 56% similar to gi|15895667 from C.acetobutylicum.SMu0397 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002731
Domain

ATPase, BadF/BadG/BcrA/BcrD type
PF01869	$\"[4-254]T$ $\"[318-572]T$	BcrAD_BadFG

InterPro
IPR008275
Domain

CoA enzyme activase
PD006344	$\"[8-251]T$ $\"[323-569]T$	CoA_E_activase
TIGR00241	$\"[2-253]T$ $\"[316-571]T$	CoA_E_activ

noIPR
unintegrated

unintegrated
SSF53067	$\"[1-252]T$ $\"[314-578]T$	SSF53067

","BeTs to 6 clades of COG1924COG name: Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)Functional Class: IThe phylogenetic pattern of COG1924 is aMt--qV-e------------Number of proteins in this genome belonging to this COG is 1","***** IPB002731 (BadF/BadG/BcrA/BcrD ATPase family) with a combined E-value of 2.4e-20. IPB002731A 4-17 IPB002731C 97-108 IPB002731D 116-131 IPB002731E 157-190","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 12:22:29 2002","Wed Apr 24 16:50:13 2002","Tue Oct 22 16:18:40 2002","Wed Apr 24 16:50:13 2002","Tue Feb 5 12:13:45 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0397 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 12:22:29 2002","","No significant hits to the NCBI PDB database.","SMU.438c","","Residues 4 to 254 (E-value = 1.3e-08) place SMu0397 in the BcrAD_BadFG family which is described as BadF/BadG/BcrA/BcrD ATPase family (PF01869)Residues 318 to 572 (E-value = 4.9e-24) place SMu0397 in the BcrAD_BadFG family which is described as BadF/BadG/BcrA/BcrD ATPase family (PF01869)","Tue Feb 5 12:13:45 2002","24378928","","","","","","1","","","SMU.438c","" "SMu0398","412321","412932","612","ATGAAATTTACTGATATTCGTTATTTGCGGACGGAAAAATTAATTTTTGATGCCTTTGTTAAATTACTGAGTGACAAACCTTATGAAAAAATTACTATTCAAGATATTGCTGATGAGGCTATGATTAATCGGGCAACCTTTTATTCTCATTATGCCGATAAGGATACCTTACAGCAAGGCATTCAAAAACAAATGATTGAGCAGCTGTCCGATATGATTGATGCAGCGCAAGTTACTACTGATGATACGGTCAAGGTCAAAAAAGCAGAGAGTCTGTTAAGTCATTATTATCACAGTTTAGAAAAAAATCCCTCTATTGCTAAAATTGTTTTAAAAAATATTTCTCAAGAAATTCTTCAAAACGATTTCAGTCAATTATTGCATCAAAAATATAATCATCTCTTAACAAAACTTAATGTCACAGAATCTGGGGAACCCGTACCAACAGATTTTATTGTTGCTTATTTGACCAGCATTTTTGTTGGGACTTTGATGTGGTGGATCCAGTCTGATTTCGATATGCCTGCAAAAGAATTGGCTCGTTTGGTCATTAAACTCATTAGCAATGGTCACTTGACTGTTATGGGAGTTAATATTAATCGTGAGGATTGA","6.00","-3.56","23386","MKFTDIRYLRTEKLIFDAFVKLLSDKPYEKITIQDIADEAMINRATFYSHYADKDTLQQGIQKQMIEQLSDMIDAAQVTTDDTVKVKKAESLLSHYYHSLEKNPSIAKIVLKNISQEILQNDFSQLLHQKYNHLLTKLNVTESGEPVPTDFIVAYLTSIFVGTLMWWIQSDFDMPAKELARLVIKLISNGHLTVMGVNINRED","412929","","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Sequences 1-203 are 46% similar to gi|15674221 from L.lactis. Residues 5-187 are 28% similar to gi|15901686 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0431 (2e-16).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[15-28]T$ $\"[36-59]T$	HTHTETR
PF00440	$\"[15-61]T$	TetR_N
PS50977	$\"[9-69]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[2-76]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[8-72]T$	Homeodomain-rel

","BeTs to 7 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class:� KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 4e-09. IPB001647 27-57","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 12:27:20 2002","Tue Feb 5 12:23:51 2002","Tue Feb 5 12:27:20 2002","Tue Feb 5 12:23:51 2002","Tue Feb 5 12:23:51 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0398 is paralogously related (blast p-value < 1e-3) to SMu1171, SMu0466, SMu1750, SMu1139, SMu1936, SMu1440, and SMu1069, all transcriptional regulators.","Tue Feb 5 12:27:20 2002","","No significant hits to the NCBI PDB database.","SMU.439","","Residues 15 to 61 (E-value = 3.9e-07) place SMu0398 in the TetR_N family which is described as Bacterial regulatory proteins, tetR family (PF00440)","Tue Feb 5 12:23:51 2002","24378929","","","","","","1","","","SMU.439","1005" "SMu0399","413049","413465","417","ATGAAATTTTCTTTTGAATTGGCGGTTAATACTAAAAAAGAGGACGCTTGGACCTACTATTCTCAAGTTAATCAGTGGTTTGTCTGGGAGGGTGATTTGGAACAAATTAGTTTGGAGGGTGAATTCACTACAGGGCAAAAGGGGAAAATGAAGATGGAGGATATGCCTGAACTTGCCTTCACTTTAGTTGAGGTGCGTGAGAATCAGTGTTTTTCTGATTTAACAGCAACGCCTTTTGGCAATGTCCTCTTTGAACATGAGATACTTGAAAATCCTGACGGTACCATTAGTCTAAGGCATTCAGTTTCTTTGACAGACAGCGATACGACAGAGGAGGCTTTAGCCTTTTTGAAACAGATTTTTGCCGATGTGCCCGAAAGTGTCGGAAAGCTGAAACAAATCTTGGAGACAGTATGA","4.20","-13.56","15734","MKFSFELAVNTKKEDAWTYYSQVNQWFVWEGDLEQISLEGEFTTGQKGKMKMEDMPELAFTLVEVRENQCFSDLTATPFGNVLFEHEILENPDGTISLRHSVSLTDSDTTEEALAFLKQIFADVPESVGKLKQILETV","413462","","hypothetical protein","Cytoplasm","No significant matches in gapped BLAST.SMu0399 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF55961	$\"[15-136]T$	SSF55961

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PR00598	$\"[79-94]T$ $\"[98-114]T$ $\"[127-147]T$	HTHMARR
PF01047	$\"[41-114]T$	MarR
SM00347	$\"[34-138]T$	HTH_MARR
PS50995	$\"[14-149]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[13-123]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[9-151]T$	SSF46785

","BeTs to 5 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class:� KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","***** IPB000835 (Bacterial regulatory protein, MarR family) with a combined E-value of 4e-13. IPB000835 78-111","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:46:47 2002","Tue Feb 5 12:32:01 2002","Tue Feb 5 12:32:01 2002","Fri Jan 25 13:46:37 2002","Fri Jan 25 13:46:37 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0400 is paralogously related (blast p-value < 1e-3) to SMu1787, SMu0111, and SMu0347, transcriptional regulators.","Tue Feb 5 12:33:04 2002","","No significant hits to the NCBI PDB database.","SMU.441","","Residues 41 to 147 (E-value = 1.2e-17) place SMu0400 in the MarR family which is described as MarR family (PF01047)","Fri Jan 25 13:46:37 2002","24378931","","","","","","1","","","SMU.441","" "SMu0401","413913","414323","411","ATGGTTAAGTTCTGGGTTGGTGTTGTTTCAGAAAATCATGTTAAACGCGGTGTTGACGGCGGTTTTTGCCAGGTCTGTCATGGTAAAGGCGGTCCTTTAAGACGCATGAAAAAGGGCGATTACCTGCTCTATTACAGTCCTAAAATCGCTCTTGATTCTAATCAAAAGCTGCAGGCTTTCACAGCCGCGGGTAAGATGAAGGATGATAGGGTTTATCAATTTGAAATGGCACCGGACTTTATCCCTTTCAGGCGGGATGTTGAGTATTACAGGTCTGTCCAGCCTTGCCCGATTGAAACCGCCAGACAGCATCCAGACTGGAAAACCTATGCCAGCCAGCTACGCTACGGGCATTTTGAAGTCAGCCGAGATTTCTTTATGTATATTTTTAACGCCATGAAGTTGGAGTAA","9.90","6.81","15962","MVKFWVGVVSENHVKRGVDGGFCQVCHGKGGPLRRMKKGDYLLYYSPKIALDSNQKLQAFTAAGKMKDDRVYQFEMAPDFIPFRRDVEYYRSVQPCPIETARQHPDWKTYASQLRYGHFEVSRDFFMYIFNAMKLE","414320","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 4-133 are 44% similar to gi|16077543 from B.subtilis. Residues 10-133 are 36% similar to 36% similar to gi|2499171 from B.licheniformis.SMu0401 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002740
Family

Protein of unknown function DUF55
PF01878	$\"[3-132]T$	DUF55

","No hits to the COGs database.","***** IPB002740 (Protein of unknown function DUF55) with a combined E-value of 1.1e-13. IPB002740A 3-14 IPB002740B 16-67 IPB002740C 82-98","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 12:37:03 2002","Tue Feb 5 12:37:03 2002","Tue Feb 5 12:37:03 2002","Tue Feb 5 12:37:03 2002","Tue Feb 5 12:37:03 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0401 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 12:37:03 2002","","No significant hits to the NCBI PDB database.","SMU.442","","Residues 9 to 131 (E-value = 3.5e-06) place SMu0401 in the DUF55 family which is described as Protein of unknown function DUF55 (PF01878)","Tue Feb 5 12:37:03 2002","24378932","","","","","","1","","","SMU.442","" "SMu0402","414522","414629","108","ATGTCAGTTGGCATGGGAGTGATTGAGCGTGGCTCTTTTGATTTCTCAGCGTCAGCTATTTTACAAAAAAGAGAGACGAAATGTCTAAAGAACAAACCTTTCACCTAG","10.30","2.93","3860","MSVGMGVIERGSFDFSASAILQKRETKCLKNKPFT","414626","","hypothetical protein","Extracellular, Periplasm","No significant hits in gapped BLAST.SMu0402 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 12:38:46 2002","Tue Feb 5 12:38:46 2002","Tue Feb 5 12:38:46 2002","Tue Feb 5 12:38:46 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0402 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 12:38:46 2002","","No significant hits to the NCBI PDB database.","SMU.444","","No significant hits to the Pfam 11.0 database","Tue Feb 5 12:38:46 2002","24378933","","","","","","1","","","SMU.444","" "SMu0403","414774","415691","918","ATGTCAAAAAAACTAACCTTCCAGGAGATTATCCTCACGTTACAGCAATACTGGAATGATCAGGGTTGTATGTTGATGCAGGCTTATGATAATGAAAAAGGTGCAGGTACCATGAGTCCCTACACTTTCTTACGTGCTATTGGACCTGAGCCTTGGAATGCGGCTTATGTTGAGCCTTCTCGTCGTCCTGCCGATGGTCGTTATGGTGAAAATCCTAATCGTCTGTATCAGCACCATCAATTCCAAGTAGTTATGAAGCCATCACCAAGTAACATTCAAGAACTTTATTTGCAATCACTTGAATTACTTGGTATTAATGCCTTAGAACATGATATTCGTTTTGTTGAGGATAATTGGGAGAATCCTTCAACTGGTTCAGCTGGACTTGGTTGGGAAGTTTGGCTTGACGGTATGGAAATTACCCAGTTCACTTATTTCCAACAAGTAGGAGGATTAGCAACACAACCTGTAACCGCTGAGGTAACCTATGGTTTAGAACGTCTAGCTTCTTATATTCAAGAAGTTGATTCTGTCTATGATATTGAATGGGCACCTGGCGTTAAATATGGTGAAATTTTCAGACAGCCAGAATATGAGCATTCTAAATATTCTTTTGAAATTTCCAACCAAGAGATGCTGTTGGAGAATTTTGAAAAATTTGAAGCAGAAGCTAAACGCTGCTTGGAGGGAAGCTTAGTGCATCCAGCTTATGACTATATCCTAAAATGTTCACATACGTTCAATCTGCTTGATGCCCGTGGAGCTGTTTCGGTAACAGAACGTGCTGGTTACATTGCACGGATTCGCAATTTAGCGCGTGTGGCTGCCAAGACCTTTGTAGCCGAACGTAGACGTCTTGGTTATCCACTGTTAGATGAAATGACACGAGAAAAACTTTTGGCAGAGGAGGAAGCATAA","4.80","-13.66","35068","MSKKLTFQEIILTLQQYWNDQGCMLMQAYDNEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPSNIQELYLQSLELLGINALEHDIRFVEDNWENPSTGSAGLGWEVWLDGMEITQFTYFQQVGGLATQPVTAEVTYGLERLASYIQEVDSVYDIEWAPGVKYGEIFRQPEYEHSKYSFEISNQEMLLENFEKFEAEAKRCLEGSLVHPAYDYILKCSHTFNLLDARGAVSVTERAGYIARIRNLARVAAKTFVAERRRLGYPLLDEMTREKLLAEEEA","415688","For the beta subunit, see Smu0404.For other 'syg' genes see SMu0404 (sygB).","glycyl-tRNA synthetase alpha subunit","Cytoplasm","Several matches in gapped BLAST to gly-tRNA synthetase alpha subunits. Residues 1-304 are 92% similar to gi|15675549 from S.pyogenes. Residues 1-303 are 93% similar to gi|15903372 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0268 (1e-168).","

InterPro
IPR002310
Domain

Glycyl-tRNA synthetase, alpha subunit
PD006985	$\"[26-274]T$	tRNA_synt_2e
PR01044	$\"[59-74]T$ $\"[80-100]T$ $\"[111-135]T$ $\"[137-157]T$ $\"[160-175]T$ $\"[245-261]T$	TRNASYNTHGA
PF02091	$\"[7-290]T$	tRNA-synt_2e
TIGR00388	$\"[5-293]T$	glyQ

InterPro
IPR006194
Domain

Heterodimeric glycyl-transfer RNA synthetase
PS50861	$\"[6-280]T$	AA_TRNA_LIGASE_II_GLYAB

noIPR
unintegrated

unintegrated
G3DSA:1.20.58.180	$\"[209-290]T$	G3DSA:1.20.58.180
G3DSA:3.30.930.10	$\"[1-208]T$	G3DSA:3.30.930.10
SSF55681	$\"[5-285]T$	SSF55681

","BeTs to 8 clades of COG0752COG name: Glycyl-tRNA synthetase, alpha subunitFunctional Class: JThe phylogenetic pattern of COG0752 is -----qvceb-huj----inxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 13:34:12 2002","Tue Feb 5 12:40:11 2002","Tue Feb 5 13:54:17 2002","Mon Apr 1 13:59:14 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0403 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 13:54:17 2002","","No significant hits to the NCBI PDB database.","SMU.445","","Residues 7 to 290 (E-value = 1.2e-213) place SMu0403 in the tRNA_synt_2e family which is described as Glycyl-tRNA synthetase alpha subunit (PF02091)","Tue Feb 5 12:40:11 2002","24378934","","","","","","1","","","SMU.445","248" "SMu0404","415694","417733","2040","ATGACAAAGAATTTATTAGTCGAACTTGGTCTTGAAGAAATGCCGGCTTATGTTGTAAAGCCGAGTATCAAACAGTTACGTCAAAAAATGGGACAGTTTTTGGAGACCAATCGTCTTTCCTTTGAAAAAATAGAAATGTTTTCAACTCCTCGTCGTTTAGCTATTCGTGTTGTTCATTTGGCTGATCAGCAAAGTGATTATTCTGAAGACTTTAAGGGGCCGGCTAAGAAAATTGCTCTGGATGCTGATGGTCATTTTACTAAAGCAGCCCAAGGATTTGTTCGCGGTAAAGGATTGACAACAGATGCCATTGAATTTCGTGAGGTCAAGGGCGAAGAATATGTTTATGTCACTAAAAATGAAGCAGGCAAACCAGCTAAAGAAGTTTTAGGTGGTCTTATTGATGTATTGCAGTCTCTGACTTTCCCTGTTAATATGCATTGGGCTAATCATACTTTTGAATATATTCGTCCTGTTCATACACTTGTTGTTCTTTTGGATGATGAAGCTCTTGATCTTAATTTTCTTGATATTAAATCTGGGCGTATCAGCAGAGGCCATCGTTTTCTTGGTCAGGAAACACAAATTGCTAGCGCTGCCTCTTATGAAACTGATTTGCGAGCAGAATTTGTCATTGCTGACGCTAAAGAACGTGAAGACATGATTATTGAGCAAATTAGAGAAATTGAAAAAACCTATAATGTTTCTGTCGAAATTGATGAAGCATTGCTCAGCGAAGTGCTGAATTTGGTTGAATATCCAACAGCTTTTATGGGGAGTTTTGATGAGAAATATTTGGAATTGCCAGAAGAAGTTTTGGTAACGTCAATGAAAACGCACCAACGTTATTTTGTTGTTCGTGATCAAACTGGTAAATTATTGCCTAATTTCATTTCAGTTCGTAATGGTAATGAACAATTCATTGAAAATGTCGTTAAAGGAAATGAAAAAGTTTTATTAGCACGCTTAGAAGATGGAGAATTTTTCTGGCGTGAAGACCAAAGATTGCAGATTGCAGATCTAGTTGAAAAATTAAAATTGGTTACTTTCCATGAAAAAATTGGTTCTTTATATGAACATATGATGCGAACCAAGCAGATTGCGGCTTATCTAGCAGAACAGGCAGATTTGACGGATCAAGAAAAAGCAGAAATAGAGCGTGCAGCTAGCATCTATAAGTTTGACCTTTTGACTGGTATGGTAGGTGAATTTGATGAATTACAAGGTATCATGGGAGAAAAATATGCTACTTTAGCAGGTGAGAGTCAGGCGGTTGCAACTGCTGTTCGTGAACATTATTTGCCAATCAGCAGTGACGGTCAGCTGCCTGACAGCAAGGTAGGCGCTATTTTAGCCGTTGCTGACAAACTTGATACCCTATTGTCCTTCTTCTCAGTCGGTCTTATTCCAAGTGGTTCCAACGATCCCTATGCTCTTCGTCGTGCGACCCAAGGAATTGTTCGTATTTTAGATAAATTCGGTTGGGAAATTCCTTTGGATCGTTTAGTTGCCAATCTTTATCAATTTGACTTTGACAGTTTGACTTATCAAAATCAGGCAGATGTTCTGGCATTTATTCGTGGTCGTGTTGAAAAAATGATTGATAAGTCTGTACCAAAAGATATTAGAGAAGCAGTTCTTGACAGTTCAACACATATTGTTCGTCTGGAGGTTGAAGCAGCAGCAGCCTTGGCTGAAAAAGCTGACGAGGATCATTTTAAAGCTTCTATTGAAAGTTTATCGCGAGTCTTTAATTTAGCAGAGAAGTCTAATCATAATGAAATGGTGGACACCAGTATTTTTGAAAATGAATATGAACAAGAGCTCTTCGATGCTGTTGAAGAATTGCATTTTACAGAAGATATGACTGACAATGTTGACCGTCTTTTTGTCTTAAGTCCGATTATTGATGCTTTCTTTGATAATACAATGGTTATGGTGGATGACGAGGCTGTGAAAAAGAATCGTTTAAACTTACTGGATCGTCTGGCACAGAAAGCTAATACTATCGCAGCTTTTAATGAAATTAGGACAAAATAA","4.70","-35.51","77113","MTKNLLVELGLEEMPAYVVKPSIKQLRQKMGQFLETNRLSFEKIEMFSTPRRLAIRVVHLADQQSDYSEDFKGPAKKIALDADGHFTKAAQGFVRGKGLTTDAIEFREVKGEEYVYVTKNEAGKPAKEVLGGLIDVLQSLTFPVNMHWANHTFEYIRPVHTLVVLLDDEALDLNFLDIKSGRISRGHRFLGQETQIASAASYETDLRAEFVIADAKEREDMIIEQIREIEKTYNVSVEIDEALLSEVLNLVEYPTAFMGSFDEKYLELPEEVLVTSMKTHQRYFVVRDQTGKLLPNFISVRNGNEQFIENVVKGNEKVLLARLEDGEFFWREDQRLQIADLVEKLKLVTFHEKIGSLYEHMMRTKQIAAYLAEQADLTDQEKAEIERAASIYKFDLLTGMVGEFDELQGIMGEKYATLAGESQAVATAVREHYLPISSDGQLPDSKVGAILAVADKLDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILDKFGWEIPLDRLVANLYQFDFDSLTYQNQADVLAFIRGRVEKMIDKSVPKDIREAVLDSSTHIVRLEVEAAAALAEKADEDHFKASIESLSRVFNLAEKSNHNEMVDTSIFENEYEQELFDAVEELHFTEDMTDNVDRLFVLSPIIDAFFDNTMVMVDDEAVKKNRLNLLDRLAQKANTIAAFNEIRTK","417730","For the alpha subunit, see Smu0403.For other 'syg' genes see SMu0403 (sygA).Note tandem repeats at 416728,416770.","glycyl tRNA synthetase beta subunit","Cytoplasm","Matches in gapped BLAST to gly-tRNA synthetase beta subunits. Residues 1-679 are 68% similar to gi15675548 from S.pyogenes and are 66% similar to gi15903371 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0270 (0.0).","

InterPro
IPR002311
Domain

Glycyl-tRNA synthetase, beta subunit
PR01045	$\"[6-19]T$ $\"[49-61]T$ $\"[242-257]T$ $\"[314-330]T$ $\"[393-412]T$	TRNASYNTHGB
PF02092	$\"[5-553]T$	tRNA_synt_2f
TIGR00211	$\"[1-677]T$	glyS

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[353-469]T$	HDc

InterPro
IPR006194
Domain

Heterodimeric glycyl-transfer RNA synthetase
PS50861	$\"[359-641]T$	AA_TRNA_LIGASE_II_GLYAB

InterPro
IPR008909
Domain

DALR anticodon binding
PF05746	$\"[576-663]T$	DALR_1

","BeTs to 8 clades of COG0751COG name: Glycyl-tRNA synthetase, beta subunitFunctional Class: JThe phylogenetic pattern of COG0751 is -----qvceb-huj----inxNumber of proteins in this genome belonging to this COG is 1","***** PR01045 (Glycyl-tRNA synthetase beta subunit signature) with a combined E-value of 7.8e-37. PR01045A 6-19 PR01045B 49-61 PR01045C 242-257 PR01045D 314-330 PR01045E 393-412","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jul 20 10:36:17 2006","Tue Feb 5 13:56:21 2002","Thu Jul 20 10:29:19 2006","Mon Apr 1 14:00:49 2002","Tue Feb 5 13:56:21 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0404 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 14:00:13 2002","","No significant hits to the NCBI PDB database.","SMU.446","","Residues 5 to 553 (E-value = 9.6e-226) place SMu0404 in the tRNA_synt_2f family which is described as Glycyl-tRNA synthetase beta subunit (PF02092)Residues 576 to 663 (E-value = 3.4e-05) place SMu0404 in the tRNA-synt_1d_C family which is described as DALR anticodon binding domain (PF05746)","Thu Jul 20 10:29:19 2006","24378935","","","","","","1","","","SMU.446","32" "SMu0405","417839","418093","255","ATGGAACAAACAAAAATTGATCGTATTAATGAATTAGCACGAAAAAAGAAGACAGAAGGATTAACTGGTGCTGAAAAACTAGAACAGGAAAGACTTCGAGAAGAGTATATTGAAGGCTATCGCCGCAGCATTCGCCATCATATTGAAGGACTTAAAATCGTTGATGAAGAGGGCAATGATATTACGCCTGCAAAGCTAAAGGAAATTCAGCGTCAAAAAGGAATTCATGGTAGGAAGCCGGAAGATAATAGTTAA","9.10","1.72","9862","MEQTKIDRINELARKKKTEGLTGAEKLEQERLREEYIEGYRRSIRHHIEGLKIVDEEGNDITPAKLKEIQRQKGIHGRKPEDNS","418090","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-82 are 71% similar to gi|15675547 from S.pyogenes and 71% similar to gi|15901323 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0271 (6e-32).","

InterPro
IPR009242
Family

Protein of unknown function DUF896, bacterial
PF05979	$\"[3-67]T$	DUF896

InterPro
IPR005075
Domain

Peptidase M4, propeptide, PepSY
PF03413	$\"[57-120]T$	PepSY

noIPR
unintegrated

unintegrated
PS51257	$\"[1-21]T$	PROKAR_LIPOPROTEIN

InterPro
IPR001048
Domain

Aspartate/glutamate/uridylate kinase
G3DSA:3.40.1160.10	$\"[5-266]T$	Aa_kinase
PF00696	$\"[12-246]T$	AA_kinase
SSF53633	$\"[11-267]T$	Aa_kinase

InterPro
IPR001057
Domain

Glutamate 5-kinase
PR00474	$\"[49-63]T$ $\"[83-111]T$ $\"[123-144]T$ $\"[159-186]T$ $\"[220-240]T$	GLU5KINASE
PS00902	$\"[218-235]T$	GLUTAMATE_5_KINASE

InterPro
IPR005715
Domain

Glutamate 5-kinase, ProB-related
TIGR01027	$\"[12-269]T$	proB

InterPro
IPR011529
Family

Glutamate 5-kinase, pro-B
PIRSF000729	$\"[10-269]T$	GK

noIPR
unintegrated

unintegrated
PTHR11063	$\"[9-269]T$	PTHR11063
PTHR11063:SF2	$\"[9-269]T$	PTHR11063:SF2

","BeTs to 8 clades of COG0263COG name: Glutamate 5-kinaseFunctional Class: EThe phylogenetic pattern of COG0263 is ----YqvceBrh-----l---Number of proteins in this genome belonging to this COG is 1","***** IPB001057 (Glutamate 5-kinase) with a combined E-value of 5.4e-56. IPB001057A 35-60 IPB001057B 80-115 IPB001057C 157-190 IPB001057D 215-247","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 18:40:11 2006","Tue Feb 5 14:09:32 2002","Tue Sep 5 18:40:11 2006","Tue Apr 9 14:57:38 2002","Tue Feb 5 14:09:32 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0407 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 14:15:51 2002","","No significant hits to the NCBI PDB database.","SMU.449","","Residues 12 to 246 (E-value = 1.2e-58) place SMu0407 in the AA_kinase family which is described as Amino acid kinase family (PF00696)","Tue Feb 5 14:09:32 2002","24378938","","","Limauro,D., Falciatore,A., Basso,A.L., Forlani,G. and De Felice,M.Proline biosynthesis in Streptococcus thermophilus:characterization of the proBA operon and its productsMicrobiology 142 (Pt 11), 3275-3282 (1996)PubMed: 8969524Sleator RD, Gahan CG, Hill C.Identification and disruption of the proBA locus in Listeria monocytogenes: role of proline biosynthesis in salt tolerance and murine infection.Appl Environ Microbiol. 2001 Jun;67(6):2571-7.PMID: 11375165","","Tue Apr 9 15:02:40 2002","1","","","SMU.449","250" "SMu0408","419899","421149","1251","ATGGCAATTATTGATAATTTAGGACAAAATGCAAAAAAGGCTAGTTTTTTACTTGCTCAATTAGGTACGGAAGCGAAAAATACTGCTTTGCTTAAAGTGGCGGAAGCTTTGTTGGCAGAATTACCTTATATTTTAGAAGAAAATGCTAAAGATGTCGCCTTGGCTCAAGAACATGGTATTAGCGCTATCATGGTAGATCGTTTACGTTTGGATGAGAAACGTCTGCAAGATATTGCTTCAGGTGTTCGTGATGTGGCTGCTTTAGGTGATCCCATTGGACAGGTTGTTCGTGGTTATACGAATATGGTTGGGCTGAAAATCATTCAAAAACGTGTGCCTTTAGGTGTCATTGCTATGATTTTTGAAAGCCGTCCCAATGTATCTGTTGATGCTTTCAGCTTGGCCTTTAAGACAGGAAATGCTATCATTTTACGCGGAGGCCGTGACGCTATTTGTTCCAATACGGCTCTGGTCAATGTGATTCGTCGGACACTCGCTAGCTTTGGACTTGATGAAAATGCAGTTCAATTAGTTGAAGATACCAGCCATGAAGTTGCCAAAGAGTTGATGGCTGCGGTGGACTACGTAGATGTTCTCATACCGCGCGGCGGTGCCCGTCTGATTCAGACCGTAAAAAAGGAAGCCAAGGTACCCGTTATTGAAACAGGTGTTGGCAATGTCCATATCTATGTTGATGAGTTTGCTGACCTTGACATGGCTAGCAAGATTGTTGTTAATGCCAAAACGCAGCGACCTAGTGTCTGTAATGCAGCTGAGGGGTTACTTGTCCATGAAAAAGTTGCTTCGGATTTCTTACCAAAATTAGAAGCGGCTATTAATCAAATACATCCAGTTGAATTCCGAGCTGATGATAGGGCACAAAAGATTTTGAAAAACGCTCAACCTGCCAGTCAGGAAGATTACGCGACAGAATTTTTAGACTATATCATATCTGTTAAGATTGTTAATAGTCTTGGTGAAGCGATTGACTGGATTAATACCTATACCAGTCATCATTCAGAATCCATTATAACAAGAGATATTCAGGCAGCCGAACGCTTTCAAGATGAAGTAGATGCGGCAGCAGTTTATGTGAATGCTTCCACACGTTTTACAGATGGTTTTGTCTTTGGTTTGGGAGCAGAAATTGGTATATCAACTCAAAAATTACATGCCCGTGGGCCAATGGGTTTAGAAGCTCTAACCAGTACTAAATTTTACATTAATGGTAAAGGACAGATTAGAGAATAA","5.40","-8.13","45207","MAIIDNLGQNAKKASFLLAQLGTEAKNTALLKVAEALLAELPYILEENAKDVALAQEHGISAIMVDRLRLDEKRLQDIASGVRDVAALGDPIGQVVRGYTNMVGLKIIQKRVPLGVIAMIFESRPNVSVDAFSLAFKTGNAIILRGGRDAICSNTALVNVIRRTLASFGLDENAVQLVEDTSHEVAKELMAAVDYVDVLIPRGGARLIQTVKKEAKVPVIETGVGNVHIYVDEFADLDMASKIVVNAKTQRPSVCNAAEGLLVHEKVASDFLPKLEAAINQIHPVEFRADDRAQKILKNAQPASQEDYATEFLDYIISVKIVNSLGEAIDWINTYTSHHSESIITRDIQAAERFQDEVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALTSTKFYINGKGQIRE","421146","For other 'pro' genes see SMu1792 (proC); SMu1003 (proV);SMu0407 (proB) and SMu1623 (proS) . ","gamma-glutamyl phosphate reductase","Cytoplasm","Matches in gapped BLAST to gamma-glutamyl reductases. Residues 1-416 are 71% similar to gi|6225877 from S.thermophilus and to gi|15675534 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0284 (1e-163).","

InterPro
IPR000965
Domain

Gamma-glutamyl phosphate reductase GPR
TIGR00407	$\"[11-405]T$	proA
PS01223	$\"[322-344]T$	PROA

InterPro
IPR002086
Domain

Aldehyde dehydrogenase
PF00171	$\"[3-407]T$	Aldedh

InterPro
IPR012134
Family

Glutamate-5-semialdehyde dehydrogenase
PIRSF000151	$\"[1-416]T$	GPR
PTHR11063:SF1	$\"[1-416]T$	GSA_DH

noIPR
unintegrated

unintegrated
G3DSA:3.40.309.10	$\"[220-396]T$	G3DSA:3.40.309.10
G3DSA:3.40.605.10	$\"[4-219]T$	G3DSA:3.40.605.10
PTHR11063	$\"[1-416]T$	PTHR11063
SSF53720	$\"[1-415]T$	SSF53720

","BeTs to 8 clades of COG0014COG name: Gamma-glutamyl phosphate reductase (proline biosynthesis)Functional Class: EThe phylogenetic pattern of COG0014 is ----yqvCebrh-----l---Number of proteins in this genome belonging to this COG is 1","***** IPB000965 (Gamma-glutamyl phosphate reductase) with a combined E-value of 6.2e-154. IPB000965A 18-70 IPB000965B 116-153 IPB000965C 217-264 IPB000965D 311-357 IPB000965E 358-397***** IPB002086 (Aldehyde dehydrogenase family) with a combined E-value of 2.8e-07. IPB002086B 111-128 IPB002086C 196-216 IPB002086D 226-269 IPB002086E 292-345","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 13:37:38 2002","Tue Feb 5 14:17:48 2002","Tue Feb 5 14:53:57 2002","Tue Apr 9 15:13:26 2002","Tue Feb 5 14:17:48 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0408 is paralogously related (blast p-value < 1e-3) to SMu0131,a predicted alcohol dehydrogenase, and to SMu0618, a predicted NADP-dependent glyceraldehyde-3-phosphate dehydrogenase.","Tue Feb 5 15:02:30 2002","","No significant hits to the NCBI PDB database.","SMU.450","","Residues 3 to 410 (E-value = 3.8e-06) place SMu0408 in the Aldedh family which is described as Aldehyde dehydrogenase family (PF00171)","Tue Feb 5 14:17:48 2002","24378939","","","Limauro D, Falciatore A, Basso AL, Forlani G, De Felice M.Proline biosynthesis in Streptococcus thermophilus: characterization of the proBA operon and its products.Microbiology. 1996 Nov;142 ( Pt 11):3275-82.PMID: 8969524 [","","Tue Feb 5 14:56:57 2002","1","","","SMU.450","251" "SMu0409","421261","421365","105","ATGAAAATGAGAGCAGGACAAGTGGTGTTCATTTATAAACTGATCTTAGTCCTGCTTTTTTATGTGTTACAGAAGCTGTTTGATTTAAAGAAAGGCTGCTTTTAA","10.70","4.93","4049","MKMRAGQVVFIYKLILVLLFYVLQKLFDLKKGCF","421362","","hypothetical protein","Extracellular, Cytoplasm","No significant hits in gapped BLAST.SMu0409 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-24]?$	signal-peptide
tmhmm	$\"[5-23]?$	transmembrane_regions

InterPro
IPR002903
Family

Bacterial methyltransferase
PD004685	$\"[244-313]T$	Bact_methyltrans
PTHR11265	$\"[22-316]T$	Bact_methyltrans
PF01795	$\"[4-314]T$	Methyltransf_5
TIGR00006	$\"[1-314]T$	Bact_methyltrans

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[5-313]T$	G3DSA:3.40.50.150
PIRSF004486	$\"[6-315]T$	MraW
SSF53335	$\"[1-314]T$	SSF53335
SSF81799	$\"[117-218]T$	SSF81799

","BeTs to 12 clades of COG0275COG name: Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesisFunctional Class: MThe phylogenetic pattern of COG0275 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002903 (Methyltransferase family) with a combined E-value of 8.9e-84. IPB002903A 27-42 IPB002903B 98-132 IPB002903C 155-169 IPB002903D 205-222 IPB002903E 240-256 IPB002903F 284-313","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 09:02:03 2002","Wed Sep 6 12:21:28 2006","Wed Sep 6 12:21:28 2006","Tue Oct 8 09:02:03 2002","Tue Feb 5 15:08:01 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0410 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 09:02:03 2002","","No significant hits to the NCBI PDB database.","SMU.453","","Residues 4 to 314 (E-value = 1.8e-188) place SMu0410 in the Methyltransf_5 family which is described as MraW methylase family (PF01795)","Tue Feb 5 15:08:01 2002","24378941","","","","","","1","","","SMU.453","252" "SMu0411","422412","422735","324","ATGACAAATGAAAAACGGAGCGAAGCTCTCTCTCAAGCTTTACAAAAAAGAATCAAAACCTTTACCAGATTGGAAAAGGCTTTTTATGGTGCGATTATTATTACTGCTATCACACTGGCTGTTAGTATTATTTATTTACAAAGTCGCAGCCTACAAATTCAGCAGGAAATCAGCCATTTAAACAGCCAAATCAATGACAGAGAGACTGAATATAATAATGCTAAACAGGAAGTTAATGAACTGAGCCGCTATGATCGTATTGCGGAAATTGCTCAAAAAGCAGGTCTTACTGTGCAAAAAGATAATATTAAGAAGGTGGACTAG","10.10","3.23","12281","MTNEKRSEALSQALQKRIKTFTRLEKAFYGAIIITAITLAVSIIYLQSRSLQIQQEISHLNSQINDRETEYNNAKQEVNELSRYDRIAEIAQKAGLTVQKDNIKKVD","422732","For other 'fts' genes, see SMu0013 (ftsH); SMu0501 (ftsA);SMu0502(ftsZ);SMu0500 (ftsQ); SMu0650 (ftsW); SMu0676 (ftsY); SMu1209 (ftsX); SMu1210 (ftsE) and SMu1483 (ftsK). ","cell division protein","Membrane, Cytoplasm","Matches in gapped BLAST to FtsL proteins. Residues 1-107 are 71% similar to gi|15675532 from S.pyogenes. Residues 5-104 are 43% similar to gi|15900266 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0286 (3e-39).","

InterPro
IPR007060
Family

Septum formation initiator
PF04977	$\"[32-104]T$	DivIC

InterPro
IPR011922
Family

Cell division protein, FtsL -like
TIGR02209	$\"[25-107]T$	ftsL_broad

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 13:40:02 2002","Tue Feb 5 15:08:52 2002","Tue Feb 5 15:11:53 2002","Tue Feb 5 15:08:52 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0411 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 15:11:53 2002","","No significant hits to the NCBI PDB database.","SMU.454","","No significant hits to the Pfam 11.0 database","Tue Feb 5 15:08:52 2002","24378942","","","Sievers J, Errington J.Analysis of the essential cell division gene ftsL of Bacillus subtilis by mutagenesis and heterologous complementation.J Bacteriol. 2000 Oct;182(19):5572-9.PMID: 10986263Sievers J, Errington J.The Bacillus subtilis cell division protein FtsL localizes to sites of septation and interacts with DivIC.Mol Microbiol. 2000 May;36(4):846-55.PMID: 10844672 Daniel RA, Errington J.Intrinsic instability of the essential cell division protein FtsL of Bacillus subtilis and a role for DivIB protein in FtsL turnover.Mol Microbiol. 2000 Apr;36(2):278-89.PMID: 10792716 ","","Tue Feb 5 15:15:37 2002","1","","","SMU.454","892" "SMu0412","422739","424988","2250","ATGAAAAATTTTAAAAAGAAATTTTTGGACTATGTTGTGGGCGACCGCAGAGTACCTAGAGAAAACCGTGAACGTGTTGGACAAAATTTAATGATTTTGTCTGTCTTTATCTTTTGTGTTTTCATTGTTAACTTTATTATTATTATTGGAACGGATCGGAAATTTGGTGTTAATTTATCTAAAGGGGCGTCCTCTGTTTATCAAACCGTTCAAAAAGTTCAGGCTAAACGCGGGACTATTTATGATCGTAATGGAAATCCCATCGCAGAAGATTCAACCACTTATAATATTTATGCTGTTATTGACAAATCTTATGTGTCGACTTCCGGCGAAAAATTATATGTTCAGCCTTCACAATATGATAAAGTAGCTGATATTCTTAACCAGCATTTAGGCATGGAAAAAGATTATGTTACTGCTCAGTTAAAACAAAAGAAGCTAACGCAAGTATCTTTTGGATCTAAAGGTTCAAATATTACTTATGGAACAATGACAGATGTCACCAAAGCACTTAAAGATGCAAAAATTAAGGGAGTCGCTTTTACAACAAGTCCCGGACGTATGTATCCTAATGGGACCTTCGCTTCACAATTTATTGGTCTAGCTCAGATTAAAGAAAATAAAGATGGTAGTAAGAGCTTAGTAGGTGCAACAGGCATGGAAGCTTCTCTTGATAAAATTTTATCTGGAAAAGACGGACAAGTGACCTACCAAAAAGATAAAAATGGAAACACACTTCTAGGTGCTGCCACAACTGTAAAAAAAGCTCAAGATGGCAAAGATGTTTATACAACATTGTCTGCTCCTATTCAGACTTATTTGGAAACGCAGATGGATGCTTTCCAAAGTAAGGCTAAGGGTGCTCAGGCGAGTGCTACTCTGGTCAATGCCAAAACAGGCGAAATATTGGCAACTTCACAAAGACCAAGCTTTAATTCCGATACAAAGGAAGGTTTGGATTCTAAAGATTTTTCTTGGCAAAATGCTCTTTATCAAACCAATTATGAACCGGGTTCAACAATGAAAGTCATGTTACTCGCTGCTGCTATTGATGAAGGGGTCTTCAATCCTAACGAAACTTATAATAATGCCAGTCTGTCTATTGCTGACGCTACCATCAAAGATTGGTCAGTTAATGAAGGTATTTCGCAAGGAGGCTATCTTTCTTTCGCTCAAGGCTTTGCTTATTCTAGTAATGTAGGAATGACGCTGCTAGAACAAAAAATGGGTAATGATAATTGGCTTAATTATCTCAATAAATATCGTTTTGGCTTACCAACACGTTTTGGAATGGGCAGTGAAGCCTCAGGCCTCCTTCCATCTGATAATATGGTAACGATTGCTATGAGTGCCTTTGGTCAAGGTATTGGAGTGACACAGACACAGATGCTCAGAGCCTTTACTTCTGTCTCTAATGATGGTGTTATGTTAGAACCGCAATTTATCACCAAAATTTATGATCCTAAAACGGGAAGCAGCCGTACGGCGAAAAAAGAAGAGGCAGGCAATCCTGTTTCAGCCGATGCAGCGAAACAAACACGGCAGTATATGGTAACAGTAGGAACAGACCCTAATTACGGGACTCTCTATTCAGCCAGTTTGGGTGGTCCAGTCATTAAAGTAGGCAATCAGTCTGTTGCAGTCAAGTCAGGGACAGCTCAAATTGCTTCTGGTGACGGTTCGGGTTACTTATCTGGAAGCAATGATTATATCTATTCAGTTGTTGCTATGGTACCATCTGATAATCCTGATTTCTTGATGTATGTGACATTACAACAACCAGAATCATTTAGTGTGTCCTTCTGGCAAGATGTTGTTAATCCTGTTTTGGAAGAGGCAACATTAATGAAAGATACGCTATTGGCACCAATTGAAACACCTGAAGATCAACAGACTAAGTATTATTTACCAAATGTTATTGGAAAAAACCCAGGTAATACGGCTGATGACTTACGTCAAAATCTTGTTCACCCAATTGTGCTTGGTACAGGAAATAAAATCATTAAAACGTCTGTAAGTGTTGGTTCGAATTTGAAGGAAAATCAACAGGTTTTACTATTAACCAGCCATTTTGATACTATGCCTGATATGTATGGCTGGAGCAAGAAAAACGTTAAGAAGTTTGAAGATTGGACTGGTATCAAGGTAACTTTCAAAGGGAAAAAATCTGGAAAAGTTACCGAACAGAGTGTTAAAGTTGGCAGTAAGCTTAAAAATTTGAAAAAAATAAGAATAACCCTAGGAGAATAA","9.90","13.72","81710","MKNFKKKFLDYVVGDRRVPRENRERVGQNLMILSVFIFCVFIVNFIIIIGTDRKFGVNLSKGASSVYQTVQKVQAKRGTIYDRNGNPIAEDSTTYNIYAVIDKSYVSTSGEKLYVQPSQYDKVADILNQHLGMEKDYVTAQLKQKKLTQVSFGSKGSNITYGTMTDVTKALKDAKIKGVAFTTSPGRMYPNGTFASQFIGLAQIKENKDGSKSLVGATGMEASLDKILSGKDGQVTYQKDKNGNTLLGAATTVKKAQDGKDVYTTLSAPIQTYLETQMDAFQSKAKGAQASATLVNAKTGEILATSQRPSFNSDTKEGLDSKDFSWQNALYQTNYEPGSTMKVMLLAAAIDEGVFNPNETYNNASLSIADATIKDWSVNEGISQGGYLSFAQGFAYSSNVGMTLLEQKMGNDNWLNYLNKYRFGLPTRFGMGSEASGLLPSDNMVTIAMSAFGQGIGVTQTQMLRAFTSVSNDGVMLEPQFITKIYDPKTGSSRTAKKEEAGNPVSADAAKQTRQYMVTVGTDPNYGTLYSASLGGPVIKVGNQSVAVKSGTAQIASGDGSGYLSGSNDYIYSVVAMVPSDNPDFLMYVTLQQPESFSVSFWQDVVNPVLEEATLMKDTLLAPIETPEDQQTKYYLPNVIGKNPGNTADDLRQNLVHPIVLGTGNKIIKTSVSVGSNLKENQQVLLLTSHFDTMPDMYGWSKKNVKKFEDWTGIKVTFKGKKSGKVTEQSVKVGSKLKNLKKIRITLGE","424985","For other 'pbp' genes see SMu0544 (pbp2b); SMu0811 (pbpX); SMu1808 (pbp1b); SMu0424 (pbp1a) and SMu1771 (pbp2a).","penicillin-binding protein 2X","Membrane, Periplasm","Matches in gapped BLAST to penicillin-binding protein 2X proteins. Residues 1-749 are 65% similar to gi15675531 from S.pyogenes. Residues 6-749 are 55% similar to gi6563355 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0287 (0.0).","

InterPro
IPR001460
Domain

Penicillin-binding protein, transpeptidase
PF00905	$\"[290-611]T$	Transpeptidase

InterPro
IPR005311
Domain

Penicillin-binding protein, dimerisation domain
PF03717	$\"[72-250]T$	PBP_dimer
SSF56519	$\"[72-264]T$	PBP_dimer

InterPro
IPR005543
Domain

PASTA
PF03793	$\"[634-690]T$ $\"[692-749]T$	PASTA
SM00740	$\"[630-690]T$ $\"[691-749]T$	PASTA
PS51178	$\"[630-687]T$ $\"[688-749]T$	PASTA

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[265-622]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.30.20	$\"[633-689]T$ $\"[690-749]T$	G3DSA:3.30.30.20
G3DSA:3.40.710.10	$\"[269-618]T$	G3DSA:3.40.710.10
G3DSA:3.90.1310.10	$\"[162-264]T$	G3DSA:3.90.1310.10
SSF54184	$\"[630-690]T$ $\"[691-749]T$	SSF54184

","BeTs to 11 clades of COG0768COG name: Cell division protein FtsI/penicillin-binding protein 2Functional Class: MThe phylogenetic pattern of COG0768 is -----QVcEBRHUJ--OLINXNumber of proteins in this genome belonging to this COG is 2","***** IPB001460 (Penicillin binding protein transpeptidase domain) with a combined E-value of 5.5e-09. IPB001460A 77-85 IPB001460C 459-474","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jul 20 10:44:15 2006","Tue Feb 5 15:16:48 2002","Thu Jul 20 10:44:15 2006","Wed Apr 3 15:40:16 2002","Tue Feb 5 15:16:48 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0412 is paralogously related (blast p-value < 1e-3) to SMu0544, and SMu0424, both penicillin binding proteins.","Tue Feb 5 15:24:11 2002","Thu Jul 20 10:44:15 2006","pdb1QMEA Chain A, Penicillin-Binding Protein 2x (Pbp-2x) >gi... 809 0.0pdb1PMD Penicillin-Binding Protein 2x (Pbp-2x) 785 0.0","SMU.455","","Residues 72 to 250 (E-value = 1.3e-41) place SMu0412 in the PBP_dimer family which is described as Penicillin-binding Protein dimerisation domain (PF03717)Residues 290 to 611 (E-value = 9.7e-83) place SMu0412 in the Transpeptidase family which is described as Penicillin binding protein transpeptidase domain (PF00905)Residues 632 to 690 (E-value = 7.2e-09) place SMu0412 in the PASTA family which is described as PASTA domain (PF03793)Residues 692 to 749 (E-value = 1.8e-07) place SMu0412 in the PASTA family which is described as PASTA domain (PF03793)","Thu Jul 20 10:44:15 2006","24378943","","","Thomas B, Wang Y, Stein RL.Kinetic and mechanistic studies of penicillin-binding protein 2x from Streptococcus pneumoniae.Biochemistry. 2001 Dec 25;40(51):15811-23.PMID: 11747459 Dessen A, Mouz N, Gordon E, Hopkins J, Dideberg O.Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations.J Biol Chem. 2001 Nov 30;276(48):45106-12.PMID: 11553637","","Tue Feb 5 15:22:30 2002","1","","","SMU.455","34" "SMu0413","424990","426009","1020","ATGTTAACCACTACAATCATCGCAGGAATTATTTCTTTTATCTTAACCATTCTTGCCATGCCATTTTTCATCCGGTTCTATCAATTGAAAAAAATCAATGGACAACAAATGCACGAAGATGTGAAGCAACATTTAGCTAAGGCTGGGACTCCAACCATGGGGGGGACAGTGTTTCTTCTTGTAGCAGCTTTAGTTACCTTTATCTGTGCATTCGTTCTTCATATTACTGGAGGGCCTGCTTTTGGGGCCACCTTGGCTATTCTTTTTATTGTCTTAATTTATGGAACTATTGGATTTTTGGATGATTTCTTAAAGATTTTTAAAAAAATTAACCAAGGTCTAACAGCTTGGCAAAAAATGGCCTTGCAGCTTATTGGCGGTCTTGTTTTCTACCTTGTTCATGTTAAACCAAGCGGTACAGATTCCTTAAATCTTTTTGGTTTTCCTTTGCATTTGGGCGTGTTTTACATTATTTTTATTCTGTTTTGGGTTGTTGGTTTTTCAAATGCCGTCAATTTGACGGATGGTATTGATGGCTTGGCTTCCATTTCAGTGGTTATCAGTCTGCTAACTTATAGTGTTATTGCATATGTGCAAAACCAATTTGATGTTCTCTTGATTATCATTTCCATGGTTGGTGCTTTACTAGGCTTTTTTGTCTATAATCACAAACCAGCTAAGGTTTTCATGGGAGATGTTGGTAGTTTAGCCTTAGGAGCAATGTTGGCAGCTATTTCAATTACACTTCGTCAGGAATGGACTTTACTGATTATTGGTATTGTCTATGTGCTTGAGACGGCTTCTGTGATGCTTCAAGTATCTTATTTTAAATGGACTAAAAAGCGCAAAGGAGAAGGGCAGCGTATTTTTAGGATGACACCTTTTCATCACCATCTTGAACTTGGTGGCTTACGTCTAAGAGAATCTGGTAAAAAGTGGTCTGAGTGGCAGGTTGATTTTTTTCTTTGGTCAATAGGTCTTCTCGGGAGTTTACTTATTTTAGCGATTTTATATTTATAA","10.30","10.10","37664","MLTTTIIAGIISFILTILAMPFFIRFYQLKKINGQQMHEDVKQHLAKAGTPTMGGTVFLLVAALVTFICAFVLHITGGPAFGATLAILFIVLIYGTIGFLDDFLKIFKKINQGLTAWQKMALQLIGGLVFYLVHVKPSGTDSLNLFGFPLHLGVFYIIFILFWVVGFSNAVNLTDGIDGLASISVVISLLTYSVIAYVQNQFDVLLIIISMVGALLGFFVYNHKPAKVFMGDVGSLALGAMLAAISITLRQEWTLLIIGIVYVLETASVMLQVSYFKWTKKRKGEGQRIFRMTPFHHHLELGGLRLRESGKKWSEWQVDFFLWSIGLLGSLLILAILYL","426006","","phospho-N-acetylmuramoyl-pentapeptide-transferase","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to undecaprenyl-phosphate-UDP-MurNAc-pentapeptide transferases. Residues 5-321 are 72% similar to gi15675530 from S.pyogenes and 62% similar to gi15902349 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0288 (1e-129).","

InterPro
IPR000715
Family

Glycosyl transferase, family 4
PTHR22926	$\"[28-336]T$	Glyco_trans_4
PF00953	$\"[84-255]T$	Glycos_transf_4

InterPro
IPR003524
Family

Phospho-N-acetylmuramoyl-pentapeptide transferase
PTHR22926:SF3	$\"[28-336]T$	PNAcPpept_trans
TIGR00445	$\"[16-339]T$	mraY
PS01348	$\"[169-180]T$	MRAY_2

noIPR
unintegrated

unintegrated
signalp	$\"[1-18]?$	signal-peptide
tmhmm	$\"[5-23]?$	transmembrane_regions

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[261-337]T$	Helicase_C
SM00490	$\"[256-337]T$	HELICc
PS51194	$\"[232-385]T$	HELICASE_CTER

InterPro
IPR011545
Domain

DEAD/DEAH box helicase, N-terminal
PF00270	$\"[25-194]T$	DEAD

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[20-220]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[32-205]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-207]T$ $\"[212-379]T$	G3DSA:3.40.50.300
PTHR10967	$\"[3-440]T$	PTHR10967
PTHR10967:SF8	$\"[3-440]T$	PTHR10967:SF8

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[33-265]T$	SBP_bac_3
SM00062	$\"[32-266]T$	PBPb

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[30-163]T$	G3DSA:3.40.190.10
SSF53850	$\"[28-263]T$	SSF53850

","BeTs to 7 clades of COG0834COG name: Periplasmic amino acid binding proteinsFunctional Class: EThe phylogenetic pattern of COG0834 is A-----VCEBrHUJ---LINxNumber of proteins in this genome belonging to this COG is 8","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:58:59 2002","Tue Aug 22 13:44:05 2006","Tue Aug 22 13:44:05 2006","Fri Apr 26 08:30:11 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0416 is paralogously related (blast p-value < 1e-3) to SMu1765, SMu0846, SMu1078, SMu0741, SMu0732, SMu0739, SMu1112, and SMu0219, all involved in ABC transport.","Tue Feb 5 15:49:35 2002","","No significant hits to the NCBI PDB database.","SMU.459","","Residues 33 to 265 (E-value = 1.4e-54) place SMu0416 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)","Tue Feb 5 15:43:06 2002","24378947","","","","Mon Oct 28 13:58:59 2002","","1","","","SMU.459","520" "SMu0417","428818","429621","804","ATGTTTAATCTATTATTAACGATAAATTGGTATGACAAACTTGTTGCCAGTTTACCTAACGGTAAATTATTCAGTTGGCGGGCAGTCTTTGATGCCATTCCATCTATTTTAGAAAAGCTGCCAACAACTTTAATTTTGACTTTAGGTGGATCCATTTTTGGTCTTGTTTTGGCGCTTTTATTTGCCATTGTTAAACTTAATCGTGTTAAAATTCTCTATCCCATCCAAGCTTTCTTTGTTTCTTTTTTAAGGGGGACGCCGATCTTGGTTCAACTGATGTTGACCTATTATGGTATTCCTTTGTTACTGAAAGCCCTCAATCAAAAGATGGGGACTGATTTTAATATTAATGCTATTCCAGCATCTGTTTTTGCGATTACAGCCTTTGCTTTTAATGAAGCTGCCTACACTAGTGAAACCATTCGTGCAGCTATTCAATCTGTCAATTCTGGGGAAATTGAAGCAGCTAAGAGTTTGGGGATGACAACTGCTCAGGTTTACCGACGTGTTATCATTCCTAATGCAGCTGTGGTGGCAACTCCAACCTTGATTAATACGTTAATTGGCTTGACCAAGGGAACCTCTCTTGCCTTTAATGCCGGAATTGTTGAAATGTTTGCTCAGGCTCAGATTCTCGGTGGTAGTGATTATCGTTACTTTGAACGTTTCATTTCCGTAGCTATTATTTATTGGGGTGTTAGCATTATTATTGAACAAGTTGGTCGTCTTATCGAAAAGAAAATGGAGATTGTTTCTCCTGATCACATTGTTAAGGATCAAGCTGTGGAAGGAGGTGTGCGTTAA","10.20","5.24","29267","MFNLLLTINWYDKLVASLPNGKLFSWRAVFDAIPSILEKLPTTLILTLGGSIFGLVLALLFAIVKLNRVKILYPIQAFFVSFLRGTPILVQLMLTYYGIPLLLKALNQKMGTDFNINAIPASVFAITAFAFNEAAYTSETIRAAIQSVNSGEIEAAKSLGMTTAQVYRRVIIPNAAVVATPTLINTLIGLTKGTSLAFNAGIVEMFAQAQILGGSDYRYFERFISVAIIYWGVSIIIEQVGRLIEKKMEIVSPDHIVKDQAVEGGVR","429618","For other components see SMu0418 (NBD1) and SMu0416 (SBP1).","amino acid ABC transporter, permease","Membrane, Cytoplasm","Matches in gapped BLAST to ABC permeases. Residues 1-254 are 77% similar to gi15675528 from S.pyogenes. Residues 5-267 are 75% similar to gi15675528 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0291 (1e-115).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[36-250]T$	BPD_transp_1
PS50928	$\"[40-241]T$	ABC_TM1

InterPro
IPR002197
Domain

Helix-turn-helix, Fis-type
PR01590	$\"[139-156]T$ $\"[156-176]T$	HTHFIS

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[32-143]T$	HEQRo_perm_3TM

","BeTs to 7 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","***** IPB000515 (Binding-protein-dependent transport systems inner membrane component) with a combined E-value of 7.4e-07. IPB000515 154-173","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 10:16:58 2002","Wed Sep 6 15:00:47 2006","Wed Sep 6 15:00:47 2006","Fri Apr 26 08:29:48 2002","Tue Feb 5 15:50:31 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0417 is paralogously related (blast p-value < 1e-3) to SMu0848, SMu1111, SMu0732, SMu0219, SMu0847, SMu0516, SMu1080, SMu1382, SMu1383, and SMu0232, all ABC permeases.","Tue Feb 5 15:54:59 2002","","No significant hits to the NCBI PDB database.","SMU.460","","Residues 36 to 250 (E-value = 6.2e-24) place SMu0417 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Tue Feb 5 15:50:31 2002","24378948","","","","","","1","","","SMU.460","254" "SMu0418","429621","430364","744","ATGATTCGCATTTCCAATTTAACCAAGGAATTTTCTGGACAAAAAGTCTTAGATGGTCTGAATCTGGATATTGAAAAGGGAGAAGTTGTAGCCCTTGTCGGTGCTTCTGGTGCTGGGAAATCAACCTTTTTACGCAGTATGAATTACCTAGAGCAGCCTGATTCAGGCAGCATTGAAATTGATGATTTTAAGATTAATTTCGATACTATTAGCAAAGAAGAGATTTTAACTTTGCGTCGTAAATTAGCCATGGTTTTCCAACAGTTTAACCTTTTTGAGCGTCGGACAGCGCTTGATAATGTTAAAGAAGGTCTTAAGATTGTTAAGAAATTGCCAGATGATGAAGCAACTAAAATTGCTAAAGAAGAATTAGCCAAGGTTGGACTTTCTGATCGGGAAAATCATTATCCGCGCCATCTTTCAGGAGGTCAAAAGCAACGTGTTGCTTTGGCTCGTGCTCTGGCCATGAAACCAGATGTTCTTTTGCTTGATGAACCAACTTCAGCGCTAGATCCAGAACTTGTTGGTGAAGTCGAAAAGTCAATTGCTGATGCTGCTAAATCAGGTCAAACCATGGTATTGGTTAGTCATGATATGAGCTTTGTTCGTCAGGTGGCGGATAAAGTTCTATTTCTTGAAAAGGGACATATTCTTGAGCAGGGAACGCCGGATCAACTTTTTAATCATCCTCAAGAAAAACGCACAGAAGAATTTTTTGCTAGTTACAAAAAAACCTTTATTTGA","6.10","-2.78","27676","MIRISNLTKEFSGQKVLDGLNLDIEKGEVVALVGASGAGKSTFLRSMNYLEQPDSGSIEIDDFKINFDTISKEEILTLRRKLAMVFQQFNLFERRTALDNVKEGLKIVKKLPDDEATKIAKEELAKVGLSDRENHYPRHLSGGQKQRVALARALAMKPDVLLLDEPTSALDPELVGEVEKSIADAAKSGQTMVLVSHDMSFVRQVADKVLFLEKGHILEQGTPDQLFNHPQEKRTEEFFASYKKTFI","430361","For other components see SMu0417 (MSD1) and SMu0416 (SBP1).","amino acid ABC transporter, ATP-binding protein","Cytoplasm, Membrane","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0292 (1e-117).","

InterPro
IPR001579
Active_site

Glycoside hydrolase, chitinase active site
PS01095	$\"[17-25]?$	CHITINASE_18

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[140-182]T$	ABC_transporter
PF00005	$\"[27-215]T$	ABC_tran
PS00211	$\"[140-154]T$	ABC_TRANSPORTER_1
PS50893	$\"[2-239]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-216]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-243]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-241]T$	PTHR19222
PTHR19222:SF33	$\"[2-241]T$	PTHR19222:SF33
SSF52540	$\"[1-243]T$	SSF52540

","BeTs to 6 clades of COG1126COG name: ABC-type polar amino acid transport system, ATPase componentFunctional Class: EThe phylogenetic pattern of COG1126 is a-----vcEB-Huj----inxNumber of proteins in this genome belonging to this COG is 7","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 8.2e-43. IPB001140A 16-62 IPB001140B 137-175 IPB001140C 192-221***** IPB001324 (Phosphoribulokinase family) with a combined E-value of 4.7e-07. IPB001324A 26-47","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 09:56:46 2002","Wed Sep 6 15:07:43 2006","Wed Sep 6 15:07:43 2006","Thu Apr 25 18:03:48 2002","Tue Feb 5 15:55:53 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0418 is paralogously related (blast p-value < 1e-3) to SMu0849, SMu0517, SMu0218, SMu0731, SMu1380, SMu1762, SMu1079, SMu0971, SMu1920, SMu1003, SMu1949, SMu1210, SMu0884, SMu1068, SMu0786, SMu0235, SMu1518, SMu0594, SMu1950, SMu1036, SMu1751, SMu1428, SMu1023, SMu0805, SMu1288, SMu1246, SMu1231, SMu0234, SMu1037, SMu1517, SMu0944, SMu0950, SMu0390, SMu0916, SMu0907, SMu0335, SMu1649, SMu0374, SMu1757, SMu1410, SMu1001, SMu0258, SMu1064, SMu0216, SMu0825, SMu1710, SMu1811, SMu0596, SMu0476, SMu1959, SMu1065, SMu1093, SMu0976, SMu0837, SMu0836, SMu0475, SMu0164, SMu0824, SMu0823, SMu1724, SMu0752, SMu0666, SMu0986, SMu1306, SMu1545, SMu0987, SMu1050, SMu0729, SMu0024, SMu0224, SMu1316, SMu1202, and SMu1686 all with ATP-binding capabilities.","Fri Apr 26 08:17:55 2002","Wed Sep 6 15:07:43 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 224 1e-059pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 138 7e-034","SMU.461","","Residues 27 to 215 (E-value = 2.5e-66) place SMu0418 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Feb 5 15:55:53 2002","24378949","","","","Tue Oct 29 09:56:46 2002","","1","","","SMU.461","255" "SMu0419","430413","430637","225","ATGTTAGTAGAGATTTTTAATTTGTATATTCAAGGTCTTCTTATGTCTGCTTTGGCAGTTATTTTAGTTAGTGCGGGTTGGATTCTTTATCGTGCTATTAGAAAAAAAGATAAGACTTCTAAAGAGCGTTTAACAATTTTATATGAAGCTTTATTGATAGATTTGGTCACCATTCCTATTTTGTCTTTTGCTTTTATGGCTATTATTCTAATGTTCAAAGCATAA","10.40","2.98","8416","MLVEIFNLYIQGLLMSALAVILVSAGWILYRAIRKKDKTSKERLTILYEALLIDLVTIPILSFAFMAIILMFKA","430634","","Streptococcus-specific protein","Membrane, Cytoplasm","Matches in gapped BLAST to only strep spp. Residues 1-74 are 54% similar to gi13622726 from S.pyogenes and 39% similar to gi15901309 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0293 (6e-18).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-25]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[51-71]?$	transmembrane_regions

InterPro
IPR000103
Domain

Pyridine nucleotide-disulphide oxidoreductase, class-II
PR00469	$\"[3-25]T$ $\"[36-51]T$ $\"[56-66]T$ $\"[101-109]T$ $\"[123-135]T$ $\"[138-162]T$ $\"[190-206]T$ $\"[229-250]T$ $\"[263-281]T$	PNDRDTASEII

InterPro
IPR000759
Family

Adrenodoxin reductase
PR00419	$\"[3-25]T$ $\"[143-157]T$	ADXRDTASE

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[107-175]T$	FAD_pyr_redox
PF00070	$\"[142-235]T$	Pyr_redox

InterPro
IPR005982
Domain

Thioredoxin reductase
TIGR01292	$\"[2-300]T$	TRX_reduct

InterPro
IPR008255
Active_site

Pyridine nucleotide-disulphide oxidoreductase, class-II, active site
PS00573	$\"[130-150]T$	PYRIDINE_REDOX_2

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[3-25]T$ $\"[103-112]T$ $\"[142-167]T$ $\"[228-242]T$ $\"[268-275]T$	FADPNR
PF07992	$\"[3-278]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[1-300]T$	G3DSA:3.50.50.60
PTHR22912	$\"[5-298]T$	PTHR22912
SSF51905	$\"[1-300]T$	SSF51905

InterPro
IPR006405
Family

Nicotinate phosphoribosyltransferase related
TIGR01513	$\"[8-464]T$	NAPRTase_put

InterPro
IPR007229
Family

Nicotinate phosphoribosyltransferase and related
PTHR11098:SF1	$\"[9-482]T$	NAPRTase
PF04095	$\"[153-366]T$	NAPRTase

noIPR
unintegrated

unintegrated
G3DSA:3.20.140.10	$\"[9-379]T$	G3DSA:3.20.140.10
PTHR11098	$\"[9-482]T$	PTHR11098

","BeTs to 9 clades of COG1488COG name: Nicotinic acid phosphoribosyltransferaseFunctional Class: HThe phylogenetic pattern of COG1488 is a--kyqvcebR---gpol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 13:50:45 2002","Fri Feb 8 13:41:02 2002","Fri Feb 8 13:50:24 2002","Wed Apr 10 16:14:40 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0421 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 13:50:24 2002","","No significant hits to the NCBI PDB database.","SMU.464","","Residues 6 to 366 (E-value = 4.2e-30) place SMu0421 in the NAPRTase family which is described as Nicotinate phosphoribosyltransferase (NAPRTase) family (PF04095)","Fri Feb 8 13:41:02 2002","24378952","","","Gross JW, Rajavel M, Grubmeyer C.Kinetic mechanism of nicotinic acid phosphoribosyltransferase: implications for energy coupling.Biochemistry. 1998 Mar 24;37(12):4189-99.PMID: 9521741","","Fri Feb 8 13:50:24 2002","1","","","SMU.464","36" "SMu0422","433535","434359","825","ATGAGTTTACAAGAAGATATTATTACTCAGTTGGGTGTTAAACCTAAAATTGATGCTCAAGAAGAAATCCGTAAATCCATTGACTTTCTTAAAGCTTACATGAAGAAGCATGGCTTTTTGAAATCTTATGTTTTAGGAATTTCAGGTGGTCAAGATTCCAGTCTTGCTGGTCGTCTAGCGCAACTTGCTATTGAGGAATTACGTCATGAAACGGGTGATAATGGCTATAAATTTATAGCTATCCGTCTGCCTTATGGTGTACAGGCTGACGAAGATGATGCACAACGAGCGCTCAATTTTATTCAGCCTGATGTCAGTCTTGCTATCAATATTAAACCTGCTGTTGATGGGGAAGTCGCTGCCTTAGCAGAGGCTGGAGTTCAAGTTTCTGACTTTAATAAGGGAAATATCAAGGCACGTCAGCGGATGATTAGTCAGTATGCTGTTGCTGGTGAAAATGGCGGAGCTGTCATTGGAACAGATCATGCTGCTGAAAACATTACTGGTTTCTTTACTAAATTTGGCGATGGTGGAGCTGATATTTTACCTTTATATCGTCTCAATAAACGTCAAGGTAAGCAGCTGTTAGCAGAATTAGGAGCTGATAAGGCTCTCTATGAAAAAATTCCAACCGCAGACCTTGAAGAAAATAAACCCGGTATCGCTGATGAAGTTGCCCTTGGCGTGACCTATAATGATATCGACGATTATTTAGAGGGCAAGCAAGTCTCCCCAGCAGCCCAGAAAATAATTGAAAATTGGTGGAACAAAACAGAACATAAACGTCATTTACCGATTTCTATCTTTGATGATTTTTGGAAGTAA","5.00","-7.78","30160","MSLQEDIITQLGVKPKIDAQEEIRKSIDFLKAYMKKHGFLKSYVLGISGGQDSSLAGRLAQLAIEELRHETGDNGYKFIAIRLPYGVQADEDDAQRALNFIQPDVSLAINIKPAVDGEVAALAEAGVQVSDFNKGNIKARQRMISQYAVAGENGGAVIGTDHAAENITGFFTKFGDGGADILPLYRLNKRQGKQLLAELGADKALYEKIPTADLEENKPGIADEVALGVTYNDIDDYLEGKQVSPAAQKIIENWWNKTEHKRHLPISIFDDFWK","434356","For other 'nad' genes see SMu1637 (nadD).","NAD(+) synthetase (nitrogen-regulatory protein)","Cytoplasm","Matches in gapped BLAST to NAD-synthetases. Residues 1-274 are 78% similar to gi15673084, the predicted enzyme from L.lactis and are 78% similar to gi15901273, the predicted enzyme from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0296 (1e-124).","

InterPro
IPR003694
Domain

NAD+ synthase
PF02540	$\"[22-265]T$	NAD_synthase
TIGR00552	$\"[15-274]T$	nadE

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[2-274]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
PTHR23090	$\"[122-274]T$	PTHR23090
PTHR23090:SF2	$\"[122-274]T$	PTHR23090:SF2
SSF52402	$\"[2-274]T$	SSF52402

","BeTs to 14 clades of COG0171COG name: NAD synthaseFunctional Class: HThe phylogenetic pattern of COG0171 is amtkyqVcebr-ujgpol---Number of proteins in this genome belonging to this COG is 1","***** IPB003694 (NAD+ synthase) with a combined E-value of 4.5e-39. IPB003694A 44-63 IPB003694B 136-148 IPB003694C 156-192 IPB003694D 202-214","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 15:45:42 2006","Fri Feb 8 13:51:43 2002","Wed Sep 6 15:45:42 2006","Thu Apr 11 11:13:33 2002","Fri Feb 8 13:51:43 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0422 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 13:58:40 2002","Wed Sep 6 15:45:42 2006","pdb2NSYA Chain A, Crystal Structure Of Nh3-Dependent Nad+ Syn... 313 1e-086","SMU.465","","Residues 83 to 269 (E-value = 2.8e-50) place SMu0422 in the NAD_synthase family which is described as NAD synthase (PF02540)","Fri Feb 8 13:51:43 2002","24378953","","","Devedjiev Y, Symersky J, Singh R, Jedrzejas M, Brouillette C, Brouillette W, Muccio D, Chattopadhyay D, DeLucas L.Stabilization of active-site loops in NH3-dependent NAD+ synthetase from Bacillus subtilis.Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):806-12.PMID: 11375500Magni G, Amici A, Emanuelli M, Raffaelli N, Ruggieri S.Enzymology of NAD+ synthesis.Adv Enzymol Relat Areas Mol Biol. 1999;73:135-82, xi. Review.PMID: 10218108","","Fri Feb 8 13:58:40 2002","1","","","SMU.465","257" "SMu0423","434472","435806","1335","ATGTCTCAATTAACACAAACATTTACAGATAAATTATTTGCTGATTATGAAGCAAATACTAAATTTCATGCTGTTGAAAATGCTGTAACCCATAACGGTTTATTAAAATCGCTTGAAACACGCCAAAGTCAAGTAGAAAACGATCATGTTTTTTCCATTGATTTGACCAAAGATGAGGTTTCTAACCAAAAAGCTTCTGGACGTTGCTGGATGTTTGCAGCACTCAACACTTTTCGTCACAAACTTATTTCAGACTTCAAGTTGGAAAACTTTGAATTGTCACAAGCCCATACCTTCTTCTGGGATAAATACGAAAAGTCAAACTGGTTCTTAGAACAAGTCATTGCGACAGCGGATGAAGAACTTGCTAGTCGCAAAGTGAAATTTCTGCTTGATACGCCCCAACAAGATGGTGGACAATGGGATATGGTTGTCGCTCTTTTTGAAAAATATGGTGTTGTGCCTAAATCGGTCTATCCAGAATCTATCTCATCAAGTGCTAGCCGTGAATTAAACCAATATCTCAATAAATTGCTGCGCCAAGATGCTCAAATTTTACGCCAAATCCTTGCAGCAGGAGCAGACAGTAAAGCTGTTCAAGCCAAGAAGGAAGAACTTTTACAAGAAATCTTTAATTTTCTTGCGATGAATCTTGGTTTGCCACCACGCCACTTTGATTTTGCCTATCGTGATAAAGATAATCATTATCAATCTGAAAAAAAGATTACACCACGAGCCTTTTATAAAAAATACGTTGGTCTTAATCTGTCAGACTATGTTTCGATTATCAATGCCCCAACGGCGGACAAGCCTTATGGGAAATCTTATACAGTTGACATGTTAGGTAATGTTGTAGGCAGCCCTGCTGTACGCTATCTCAATCTAGAAATGGAACGTTTTAAAGAGTTAGCTATTGCTCAGATGCGGGCTGGCGAAACAGTCTGGTTTGGCTCTGATGTGGGTCAGGTATCCGACCGTCAAAAGGGAATCTTAGCTACTAATACCTATGATTTTAAGGCTGCTATGAATATTGATCTGACACAAGACAAGGCTGGTCGTTTGGACTATAGTGAAAGCCTCATGACCCATGCTATGGTTTTGACTGGTGTTGATTTGGATGAAAATGGCAAAGCTATTAAATGGAAAGTCGAAAATTCATGGGGGGATAAGGTTGGTCAAAAAGGCTACTTTGTTGCTTCAGATGTTTGGATGGATGAATACACTTATCAAATCGTTGTTCGTAAGGAATTTCTTACTGCTGAGGAACTAGCGGCTTATGAAGAGGCACCACAAGTTCTGGCACCTTGGGATCCAATGGGGGCTCTCGCAAAATAA","5.30","-9.08","50561","MSQLTQTFTDKLFADYEANTKFHAVENAVTHNGLLKSLETRQSQVENDHVFSIDLTKDEVSNQKASGRCWMFAALNTFRHKLISDFKLENFELSQAHTFFWDKYEKSNWFLEQVIATADEELASRKVKFLLDTPQQDGGQWDMVVALFEKYGVVPKSVYPESISSSASRELNQYLNKLLRQDAQILRQILAAGADSKAVQAKKEELLQEIFNFLAMNLGLPPRHFDFAYRDKDNHYQSEKKITPRAFYKKYVGLNLSDYVSIINAPTADKPYGKSYTVDMLGNVVGSPAVRYLNLEMERFKELAIAQMRAGETVWFGSDVGQVSDRQKGILATNTYDFKAAMNIDLTQDKAGRLDYSESLMTHAMVLTGVDLDENGKAIKWKVENSWGDKVGQKGYFVASDVWMDEYTYQIVVRKEFLTAEELAAYEEAPQVLAPWDPMGALAK","435803","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). ","cysteine aminopeptidase C","Cytoplasm, Extracellular","Matches in gapped BLAST to cysteine aminopeptidase C. Residues 1-443 are 83% similar to gi|3024365 from S.thermophilus. Residues 1-444 are 83% similar to gi|15675522, the predicted enzyme from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0297 (0.0).","

InterPro
IPR000169
Active_site

Peptidase, cysteine peptidase active site
PS00139	$\"[63-74]T$	THIOL_PROTEASE_CYS
PS00639	$\"[361-371]?$	THIOL_PROTEASE_HIS

InterPro
IPR004134
Family

Peptidase C1B, bleomycin hydrolase
PIRSF005700	$\"[1-444]T$	PepC
PTHR10363	$\"[2-444]T$	Peptidase_C1B
PF03051	$\"[3-440]T$	Peptidase_C1_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.70.10	$\"[50-443]T$	G3DSA:3.90.70.10
PTHR10363:SF2	$\"[2-444]T$	PTHR10363:SF2
SSF54001	$\"[4-443]T$	SSF54001

","No hits to the COGs database.","***** IPB000169 (Eukaryotic thiol (cysteine) proteases active site) with a combined E-value of 1.2e-12. IPB000169A 63-72 IPB000169C 361-371 IPB000169D 380-396","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 13:53:11 2002","Fri Feb 8 13:59:31 2002","Fri Feb 8 14:03:53 2002","Fri Feb 8 13:59:31 2002","Fri Feb 8 13:59:31 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0423 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 14:03:53 2002","Fri Feb 8 13:59:31 2002","pdb|1CB5|A Chain A, Human Bleomycin Hydrolase. >gi|7546635|pdb|... 323 2e-089pdb|2CB5|A Chain A, Human Bleomycin Hydrolase, C73sDELE455 MUTA... 318 7e-088pdb|1GCB| Gal6, Yeast Bleomycin Hydrolase Dna-Binding Proteas... 298 9e-082","SMU.466","","Residues 3 to 440 (E-value = 5.1e-299) place SMu0423 in the Pept_C1-like family which is described as Peptidase C1-like family (PF03051)","Fri Feb 8 13:59:31 2002","24378954","","","Winters DK, Ivey DM, Maloney TP, Johnson MG.Characterization by molecular cloning and sequencing of the gene encoding an aminopeptidase from Listeria monocytogenes.Antonie Van Leeuwenhoek. 2000 Aug;78(2):141-51.PMID: 11204766","","Fri Feb 8 14:03:53 2002","1","","","SMU.466","37" "SMu0424","438045","435922","2124","ATGACAGTTCTAAAATATGGACTAGGTATTCTCTTAAGCGCTATTATTTTAGCCATTATAATTGGAGGTCTTCTGTTTACCTATTATGTCAGCAGTACTCCTAAACTATCAGAAGCTAAACTTAAAGCTACTAATTCTAGTTTGGTTTATGATAGCAATAATAATCTGATTGCTGATTTAGGTGCTGAAAAGCGCGAAAGTATTTCTTCAGACAGTATTCCAATGAAGTTAGTAAATGCCGTTACCTCTATTGAAGATCACCGTTTCTTTAAACATCGTGGTGTCGACATTTATCGTATTATTGGTGCAGCTTGGAGTAATTTACTTCATAAATCAACTCAAGGGGGATCCACTCTTGATCAGCAGCTTATCAAGCTGGCCTATTTCTCTACTAAAGAGTCTGATCAGACCTTAAAACGTAAAGCTCAAGAAGTTTGGCTGTCTCTACAAATGGAGAAAAAATACACGAAAGAAGAGATTCTAACTTTTTATGTCAATAAGGTTTACATGGGTAATGGGAATTACGGAATGCGCACTGCTGCAAAGTCTTATTATGGCAAGGATCTTAAAGACTTATCAATTGCCCAGCTAGCGACACTCGCAGGTATTCCGCAAGCACCGACACAATATGATCCTTACGCTCAGCCAAAGGCAGCTACAAGCAGACGTAATACCGTTTTGTCACAGATGTATAAACATAAAAAAATTACAAAACGAGAATATGATGCTGCAGTAGCAACACCAATTTCTGATGGCCTGCAAGAACTGAAACGCTCCTCTAGTTATCCAAAATATATGGATAATTATCTGAAACAGGTTATTTCAGAGGTGAAAAAACGTACTGGTCAAGATATCTTTTCAGCAGGCATGAAGGTTTATACAAATGTTAATGCCGATGCACAGCAATATCTCTGGAACATTTATAATACAGATGAATATATTGCTTATCCTGATGATAATTTCCAAGTTGCTTCTACTGTTATGGATGTTACTAATGGTAAAGTTATTGCACAGCTTGGCGGACGCCATCAAGATACCAATGTTTCTTTTGGTACCAATCAGGCTGTCTTAACTGATCGTGACTGGGGATCAACCATGAAACCTATTTCAGCATATGGCCCTGCTCTTGAAAGCGAAGCTTTTACGACAACTGCACAGATGCTAAATGACTCGGTCTATTATTATCCAGGTACAACAACACAAGTCTATGACTGGGATCATCGTTATAATGGTTGGATGACTATCCAAACGGCTATCCAACAATCTCGTAATGTCCCTGCTGTCAGAGCTATTGATGCCGCTGGATTAGATACTGCCAAAGGTTTCTTAAGCGGTCTCGGTATTGATTATCCTGAGATGCGTTATTCAAACGCCATTTCAAGTAATACAAGTAGTTCAGAACAAAAGTATGGTGCCAGCAGTGAAAAAATGGCCGCCGCTTATGCTGCTTTTTCTAATGGTGGAACTTATTATGAACCACAATACGTCAATAAAATAGAATTTAAGGATGGAACATCAGAGACCTATGATGCTAAAGGCAATCGTGCGATGAAAGAAACGACAGCCTACATGATGACAGATATGTTAAAAACAGTATTAACATATGGTACTGGTACTGAGGCTGCTATTCCTGGTCTTTATCAAGCAGGTAAAACAGGAACATCCAACTATGATGACAATGAATTGGTAGAGATGTCTGAAAAACTTGGTATTAATCCTTATGGACTTGGTACTATTGCTCCAGATGAAAACTTTGTTGGTTATACACCTCAGTATTCAATGGCTGTTTGGACAGGATATAAAAATCGCTTAATGCCTGTTTACGGAGACAGTATGAAAATTGCTGCGCAAGTCTATCGTACTATGATGGCTTATCTTTCTAGCTCAGGTAATTCTGATTGGACCATGCCTGACGGTCTCTATCGCAGCGGTGGTTATCTTTACCTAAATGGTTCAAGTGGGTCAAATAGTAGGTATGGTGCAGCTCCTGCAACTTCATCGTCATCTTCTTCATCATCTTCTTCTGATTCAAACAATAACGATCAAAATAATAATCAAACTACAGAAGCGTCTAGTGACTCATCTTCATCAAGTTCTGATGCTACGACATCTTCTAATCCATAA","6.60","-1.52","77756","MTVLKYGLGILLSAIILAIIIGGLLFTYYVSSTPKLSEAKLKATNSSLVYDSNNNLIADLGAEKRESISSDSIPMKLVNAVTSIEDHRFFKHRGVDIYRIIGAAWSNLLHKSTQGGSTLDQQLIKLAYFSTKESDQTLKRKAQEVWLSLQMEKKYTKEEILTFYVNKVYMGNGNYGMRTAAKSYYGKDLKDLSIAQLATLAGIPQAPTQYDPYAQPKAATSRRNTVLSQMYKHKKITKREYDAAVATPISDGLQELKRSSSYPKYMDNYLKQVISEVKKRTGQDIFSAGMKVYTNVNADAQQYLWNIYNTDEYIAYPDDNFQVASTVMDVTNGKVIAQLGGRHQDTNVSFGTNQAVLTDRDWGSTMKPISAYGPALESEAFTTTAQMLNDSVYYYPGTTTQVYDWDHRYNGWMTIQTAIQQSRNVPAVRAIDAAGLDTAKGFLSGLGIDYPEMRYSNAISSNTSSSEQKYGASSEKMAAAYAAFSNGGTYYEPQYVNKIEFKDGTSETYDAKGNRAMKETTAYMMTDMLKTVLTYGTGTEAAIPGLYQAGKTGTSNYDDNELVEMSEKLGINPYGLGTIAPDENFVGYTPQYSMAVWTGYKNRLMPVYGDSMKIAAQVYRTMMAYLSSSGNSDWTMPDGLYRSGGYLYLNGSSGSNSRYGAAPATSSSSSSSSSSDSNNNDQNNNQTTEASSDSSSSSSDATTSSNP","435925","For other 'pbp' genes see SMu0544 (pbp2b); SMu0811 (pbpX); SMu1808 (pbp1b); SMu0412 (pbp2X) and SMu1771 (pbp2a).","penicillin-binding protein 1a","Extracellular, Membrane","Matches in gapped BLAST to penicillin-binding protein 1a sequences. Residues 26-638 are 72% similar to gi|15675521, the predicted enzyme from S.pyogenes. Residues 1-638 are 58% similar to gi|5410465 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0298 (0.0).","

InterPro
IPR001264
Domain

Glycosyl transferase, family 51
PD001895	$\"[137-186]T$	Glyco_trans_51
PF00912	$\"[47-216]T$	Transgly

InterPro
IPR001460
Domain

Penicillin-binding protein, transpeptidase
PF00905	$\"[323-554]T$	Transpeptidase

InterPro
IPR011816
Domain

Penicillin-binding protein 1A
TIGR02074	$\"[64-629]T$	PBP_1a_fam

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[295-631]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[320-627]T$	G3DSA:3.40.710.10

InterPro
IPR004612
Family

Recombination protein U
PF03838	$\"[26-192]T$	RecU
TIGR00648	$\"[26-192]T$	recU

noIPR
unintegrated

unintegrated
PD016557	$\"[26-171]T$	RNA_rec_mot

InterPro
IPR010697
Family

Protein of unknown function DUF1273
PF06908	$\"[1-171]T$	DUF1273

InterPro
IPR007793
Family

DivIVA
PF05103	$\"[1-112]T$	DivIVA

InterPro
IPR010989
Domain

t-snare
SSF47661	$\"[37-82]T$	t-snare

InterPro
IPR011229
Family

Uncharacterized conserved protein UCP029938
PIRSF029938	$\"[1-112]T$	UCP029938

InterPro
IPR000241
Domain

Putative RNA methylase
PF01170	$\"[167-373]T$	UPF0020

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[304-310]?$	N6_MTASE

InterPro
IPR002296
Family

N6 adenine-specific DNA methyltransferase, N12 class
PR00507	$\"[198-212]T$ $\"[301-313]T$	N12N6MTFRASE

InterPro
IPR004114
Domain

THUMP
PS51165	$\"[45-159]T$	THUMP

noIPR
unintegrated

unintegrated
SSF53335	$\"[114-326]T$	SSF53335

","BeTs to 6 clades of COG0116COG name: Predicted N6-adenine-specific DNA methylasesFunctional Class: LThe phylogenetic pattern of COG0116 is am-k---ceb-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB000241 (Uncharacterized protein family UPF0020) with a combined E-value of 2.5e-10. IPB000241 198-215","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 15:51:58 2006","Wed Sep 6 15:51:58 2006","Wed Sep 6 15:51:58 2006","Wed Sep 6 15:51:58 2006","Fri Feb 8 14:31:43 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0428 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Sep 6 15:51:58 2006","","No significant hits to the NCBI PDB database.","SMU.472","","Residues 167 to 373 (E-value = 6.9e-63) place SMu0428 in the UPF0020 family which is described as Putative RNA methylase family UPF0020 (PF01170)","Fri Feb 8 14:31:43 2002","24378959","","","","","","1","","","SMU.472","258" "SMu0429","441479","443044","1566","ATGACAATTGGTGAAGCAGTTCGTAAAGATTCCGAAATTAAGGCCGGTGTAACTGAAGAAGATAGTGTTCTAGACCGTTATATTAAGCAACATCGTGATGAAGTAACCGCACGGAAATTTGATACTAGCAGTGATGATTTTGAAAGCATTGATACTAGCACACTTGATAATTTTATTAAGCAACAGCGTCAGGAATTAGTTGACACAGGTTTAATTGATCCCATTGAGGAGCAAGAAGAAGAAATACCTTCTGCATCAGCGATTTCTGCTGACACTGCTAAAGAGCAGAGCCTAGAAGATACCATTGTGGCACCAGCTATCAATCCGAATCAGGAGATCTGGAAGAAAGACGAATTTGATGATGTTCCTTTGTCAGATACGCAAGAGACTGCTAAATTAGATACTGAGGAGAAGTCTAGTTTTTTGACTGCTCCAACTTCTGATTTGGATAAGGATGATGTTGGGAATTCTGAAGATTTTGATGAAGATGATGAAACAAAACCGCCTTTTTATAAGCGTAAAAAAGTAATCATGGCATCATTTATTGTTTTACTTTTATTGGCTGCTGGTGCTACATACAGTGTTTATCAATTGAGCCATCACACAGCAAAAACTAAGAGAACAACAAAATCAACGTCAACAAAGAAATCAACAGATTTTACAGCAGCTTCTAAAAGGTTTGAAAAGTCTTATACGGCTTTCTTTGCGGATGCAAAGAGAACGAAGTTAAAAAACAATCAATTTGCTAACTTGCCTAAATTAGAAAAACATTTGAAAAAACTTAAGGACAGCAAATATTATGACGAGGCTAAAAAGAAGTATGAAAGCTTGAAGCGTCAAATTTCAGCGATTAATGCTGTAAATGGGAAATTTAAAACGACTGCCATTCTTAATGGTGATAAAAAAGCAGCTGCTGTTAAAGATAATGCTAATTTTGATGATATTTCAGAAAAGAGCTTAAATACAGGAAATGCTACATTAGATGCCCTTTTGAAATCTGTCATTGCTGATGGACGCAAACAATTAGAAGCTAATAATAAGAAATCAGGAAGCTCAGCTGCTTCATCAAATGCCAACAGCGGTACATCATCAAATACTGAAGGCAGTAATCAAAATGCTCAAGCTCCAGCTGCTGACTCCAATACACCAGCTAATGGCTCACCTGGATCTAATAATACATCTGGTAGCACATCACCAAGTACACCTGCTGCTCCAAATAATGGGACATCAAATGCAGGTGCTTCTGGTTATGGTATTTCCAGCTATGATGTTTCTAAGCTGCAACGTGATCGTAGTCGAGTTCCTTATGACCAATCTAAGATTGCTGATAGTAACAATTCAGCTTGGGTCTTTAATGCAGGTATTTTAGAAAAAATAGTAGCTATTTCACAACAACGTGGTTATATTACAGGTAATGACTATATTCTTGAGAAAGTTAATATTATCAATGGTAATGGTTATTACAATATGTTTAAGCCAGATGGGACTTATCTTTTCTCAATTAATTGTAAAACAGGTTATTTTGTGGGAAATGCCGCCGGTCATTCGGATAAATTAGATTATTAA","5.30","-7.79","56852","MTIGEAVRKDSEIKAGVTEEDSVLDRYIKQHRDEVTARKFDTSSDDFESIDTSTLDNFIKQQRQELVDTGLIDPIEEQEEEIPSASAISADTAKEQSLEDTIVAPAINPNQEIWKKDEFDDVPLSDTQETAKLDTEEKSSFLTAPTSDLDKDDVGNSEDFDEDDETKPPFYKRKKVIMASFIVLLLLAAGATYSVYQLSHHTAKTKRTTKSTSTKKSTDFTAASKRFEKSYTAFFADAKRTKLKNNQFANLPKLEKHLKKLKDSKYYDEAKKKYESLKRQISAINAVNGKFKTTAILNGDKKAAAVKDNANFDDISEKSLNTGNATLDALLKSVIADGRKQLEANNKKSGSSAASSNANSGTSSNTEGSNQNAQAPAADSNTPANGSPGSNNTSGSTSPSTPAAPNNGTSNAGASGYGISSYDVSKLQRDRSRVPYDQSKIADSNNSAWVFNAGILEKIVAISQQRGYITGNDYILEKVNIINGNGYYNMFKPDGTYLFSINCKTGYFVGNAAGHSDKLDY","443041","","conserved hypothetical protein","Extracellular, Periplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-521 are 37% similar to gi|15675516 from S.pyogenes and are 31% similar to gi|15900297 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0304 (2e-85).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[176-196]?$	transmembrane_regions

InterPro
IPR003815
Family

LuxS protein
PD013172	$\"[11-146]T$	LuxS
PR01487	$\"[8-26]T$ $\"[31-49]T$ $\"[52-70]T$ $\"[76-94]T$ $\"[120-139]T$	LUXSPROTEIN
PIRSF006160	$\"[4-160]T$	AI2
PF02664	$\"[5-150]T$	LuxS

noIPR
unintegrated

unintegrated
G3DSA:3.30.1360.80	$\"[4-156]T$	G3DSA:3.30.1360.80
SSF63411	$\"[3-156]T$	SSF63411

","BeTs to 4 clades of COG1854COG name: LuxS protein involved in autoinducer AI2 synthesisFunctional Class: TThe phylogenetic pattern of COG1854 is --------eb-huj--o----Number of proteins in this genome belonging to this COG is 1","***** PR01487 (Bacterial autoinducer-2 (AI-2) production protein LuxS signature) with a combined E-value of 5.6e-39. PR01487A 8-26 PR01487B 31-49 PR01487C 52-70 PR01487D 76-94 PR01487E 120-139","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 14:38:34 2002","Mon Jul 24 17:34:15 2006","Tue Jul 5 10:45:20 2005","Tue Jul 5 10:45:20 2005","Fri Feb 8 14:36:06 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0430 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 14:38:34 2002","","No significant hits to the NCBI PDB database.","SMU.474c","","Residues 5 to 158 (E-value = 6.3e-47) place SMu0430 in the LuxS family which is described as LuxS protein (PF02664)","Fri Feb 8 14:36:06 2002","","","Yoshida A, Ansai T, Takehara T, Kuramitsu HK.LuxS-based signaling affects Streptococcus mutans biofilm formation.Appl Environ Microbiol. 2005 May;71(5):2372-80.PMID: 15870324Merritt J, Kreth J, Shi W, Qi F.LuxS controls bacteriocin production in Streptococcus mutans through a novel regulatory component.Mol Microbiol. 2005 Aug;57(4):960-9.PMID: 16091037","Steiner K, Malke H.relA-Independent amino acid starvation response network of Streptococcus pyogenes.J Bacteriol. 2001 Dec;183(24):7354-64.PMID: 11717294Lyon WR, Madden JC, Levin JC, Stein JL, Caparon MG.Mutation of luxS affects growth and virulence factor expression in Streptococcus pyogenes.Mol Microbiol. 2001 Oct;42(1):145-57.PMID: 11679074 Ruzheinikov SN, Das SK, Sedelnikova SE, Hartley A, Foster SJ, Horsburgh MJ, Cox AG, McCleod CW, Mekhalfia A,Blackburn GM, Rice DW, Baker PJ.The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS.J Mol Biol. 2001 Oct 12;313(1):111-22.PMID: 11601850","Wed Jun 4 20:19:38 2008","Fri Feb 8 14:43:39 2002","1","","","SMU.474c","634" "SMu0431","443832","445439","1608","ATGTTAAATATTCTTTTAACTCTTGTTTTCTCCCTCATTGGTTTGGTTATTGGTTATGCAGTTATTTCGGCTCGTTTAAAGAAAGCTAAAGAAACCGCAGAACTGACTCTTTTAAATGCAGAACAAGATGCTGTCAATGCTCGCAGTAAAGCTGAAATGGATGCTGAGCATATCAAAAAAACAGCAGAACGTGAAAGTAAGGCCTATAAAAAGGAACTGCTTATAGAAGCAAAAGAAGAGGCTAGAAAATATCGTGAAGAGATTGAAAAAGAATTTAAGTCTGAAAGACAAGAGCTCAAACAAATGGATGCGCGTTTGACAGAGCGTGCAGCATCTCTTGATCGTAAAGATGAAAATCTAAGCAGCAAAGAACAATTGCTTGATAGTAAAGAGCAAAGTCTATCCGATAAATCTAGGCATATTGATGAGCGTGAACTACAAGTTAAACAATTAGAAGTTAAAAAGGCTGAGGAACTTGAGAAAATAGCGTCCTTAAGTCAAGAACAAGCACGCGGTATTATTCTTTCGGAAACAGAGAAAAATTTAGCGCATGATATTGCGAATCGTATTAAAGAAGCAGAGCGTGAAATCAAAGATAGAACGGATAAAACGGCTAAAGATTTGTTAGCTCAAGCTATGCAACGTCTAGCAGGAGATTATGTAGCTGAACAGACCATTACGACAGTTCATCTCCCTGATGATAGCATGAAAGGTCGTATTATCGGCCGCGAAGGTCGTAATATCCGAACGCTTGAGAGCTTGACAGGTATTGATATTATTATTGACGACACACCAGAGGTGGTTGTTTTATCAGGCTTTGATCCTATTCGTCGAGAAATTGCTCGTATGACTTTAGAAGCGCTTATCCAAGATGGCCGTATTCATCCTGCTCGAATTGAAGAATTAGTTGAGAAGAATCGTCTGGAAATGGACAATCGGATTCGTGAATATGGTGAAGCTGCCGCCTTTGAAATTGGCGCTCCCAATCTTCACCCTGATTTGATTAAACTGATGGGACGTTTGCAATTTAGAACGTCTTATGGACAAAATGTTCTTCGTCATTCTGTTGAAGTTGGTAAATTAGCTGGACTTTTGGCCAGTGAGTTAGGTGAAAATGTTGATTTAGCTCGCCGTGCCGGTTTTCTACACGATATTGGAAAAGCTATCGACCGTGAGGTTGAAGGCAGTCATGTTGAGATTGGAACAGAATTTGCTCGTAAATACAAGGAAAATCCTGTTGTGATTAACACTATTGCTAGTCACCATGGTGATGTGGAAGCTCAATCGGTCATTGCTGTTTTAGTTGCTGCTGCTGATGCGCTCAGTTCAGCTCGTCCGGGTGCTCGCAATGAGTCTATGGAAAATTACATCAAACGTCTGCGTGATTTAGAAGAAATAGCAACAAGCTTTGATGGTGTTCAAAATAGCTATGCCTTGCAAGCAGGCCGTGAAATTCGCATTATGGTTCAGCCAGAAAAACTTTCTGATGATGATGTCACCATTTTAGCTCACAAGGTTCGTGAAAAAATTGAAAACAATTTGGATTATCCAGGTAATATTAAAGTTACAGTCATTCGTGAACTTCGTGCGATTGATTATGCTAAATGA","5.60","-11.01","60333","MLNILLTLVFSLIGLVIGYAVISARLKKAKETAELTLLNAEQDAVNARSKAEMDAEHIKKTAERESKAYKKELLIEAKEEARKYREEIEKEFKSERQELKQMDARLTERAASLDRKDENLSSKEQLLDSKEQSLSDKSRHIDERELQVKQLEVKKAEELEKIASLSQEQARGIILSETEKNLAHDIANRIKEAEREIKDRTDKTAKDLLAQAMQRLAGDYVAEQTITTVHLPDDSMKGRIIGREGRNIRTLESLTGIDIIIDDTPEVVVLSGFDPIRREIARMTLEALIQDGRIHPARIEELVEKNRLEMDNRIREYGEAAAFEIGAPNLHPDLIKLMGRLQFRTSYGQNVLRHSVEVGKLAGLLASELGENVDLARRAGFLHDIGKAIDREVEGSHVEIGTEFARKYKENPVVINTIASHHGDVEAQSVIAVLVAAADALSSARPGARNESMENYIKRLRDLEEIATSFDGVQNSYALQAGREIRIMVQPEKLSDDDVTILAHKVREKIENNLDYPGNIKVTVIRELRAIDYAK","445436","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-535 are 75% similar to gi|15675508 from S.pyogenes and are 66% similar to gi|15903626 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0306 (0.0).","

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[347-453]T$	HDc

InterPro
IPR004087
Domain

KH
SM00322	$\"[223-290]T$	KH

InterPro
IPR004088
Domain

KH, type 1
PF00013	$\"[226-285]T$	KH_1
PS50084	$\"[238-285]T$	KH_TYPE_1

InterPro
IPR006674
Domain

Metal-dependent phosphohydrolase, HD region, subdomain
PF01966	$\"[351-444]T$	HD

InterPro
IPR006675
Domain

HDIG
TIGR00277	$\"[347-424]T$	HDIG

noIPR
unintegrated

unintegrated
G3DSA:1.10.3150.10	$\"[349-491]T$	G3DSA:1.10.3150.10
SSF54791	$\"[214-321]T$	SSF54791

","BeTs to 7 clades of COG1418COG name: Uncharacterized hydrolases of the HD superfamilyFunctional Class:� RThe phylogenetic pattern of COG1418 is Amtk-qv-eB--ujgpol---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 14:48:51 2002","Fri Feb 8 14:47:20 2002","Fri Feb 8 14:48:51 2002","Fri Feb 8 14:47:20 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0431 is paralogously related (blast p-value < 1e-3) to SMu0259, a comA-related ABC transporter, and to SMu1375, a predicted chromosome segregation ATPase.","Fri Feb 8 14:48:51 2002","","No significant hits to the NCBI PDB database.","SMU.475","","Residues 228 to 272 (E-value = 2.7e-06) place SMu0431 in the KH family which is described as KH domain (PF00013)Residues 351 to 444 (E-value = 1.6e-25) place SMu0431 in the HD family which is described as HD domain (PF01966)","Fri Feb 8 14:47:20 2002","24378962","","","","","","1","","","SMU.475","39" "SMu0432","445886","446518","633","ATGTCTGAACGTGGTTTATTAATCGTTTTTTCAGGACCTTCTGGTGTTGGTAAAGGAACGGTTAGGCAGGAAATTTTTTCAACACCTGACCATCAATTTGAATATTCTGTTTCCATGACAACGCGTCCGCAAAGGTTGGGTGAAATTGATGGTGTTGATTACTTCTTTCGGACACGTGAGGAGTTTGAAGAACTCATTAAACAAGGCCAAATGTTAGAGTATGCTGAGTATGTTGGTAATTATTATGGCACACCTTTAACGTATGTAAATGAAACATTAGATAAAGGAATTGATGTCTTTCTTGAAATCGAGGTACAAGGCGCTCTTCAAGTTAAACAAAAGGTTCCAGACGGTGTTTTTATTTTCTTAACACCGCCGGATTTAGCAGAATTAAAGGATCGATTAGTTGGACGTGGAACAGACAGTCAGGAAGTAATTGCTCAACGCATTGAACGTGCTAAAGAAGAAATTGCCCTAATGCGCGAGTATGACTACGCTGTTGTCAATGATGAAGTAAAACTGGCAGCAGAACGAGTCAAGCATATTATTGAGACGGAGCATTTCCGTGTTGAACGTGTTATTGGCCGTTATCATAAAATGATTAATGAAGAATTGCCTTTACCCCTTAGATAA","4.80","-10.01","24205","MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHQFEYSVSMTTRPQRLGEIDGVDYFFRTREEFEELIKQGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKQKVPDGVFIFLTPPDLAELKDRLVGRGTDSQEVIAQRIERAKEEIALMREYDYAVVNDEVKLAAERVKHIIETEHFRVERVIGRYHKMINEELPLPLR","446515","","guanylate kinase","Cytoplasm","Matches in gapped BLAST to guanylate kinase sequences. Residues 1-201 are 94% similar to gi|15675507 from S.pyogenes and 84% similar to gi|15903625 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0313 (1e-102).","

InterPro
IPR008144
Family

Guanylate kinase
PF00625	$\"[41-145]T$	Guanylate_kin
PS00856	$\"[40-57]T$	GUANYLATE_KINASE_1
PS50052	$\"[5-184]T$	GUANYLATE_KINASE_2

InterPro
IPR008145
Domain

Guanylate kinase/L-type calcium channel region
SM00072	$\"[4-187]T$	GuKc

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[66-183]T$	G3DSA:3.40.50.300
PTHR23117	$\"[25-204]T$	PTHR23117
PTHR23117:SF1	$\"[25-204]T$	PTHR23117:SF1
SSF52540	$\"[3-187]T$	SSF52540

","BeTs to 11 clades of COG0194COG name: Guanylate kinaseFunctional Class:� FThe phylogenetic pattern of COG0194 is ----yqvcEbrhujgp--inxNumber of proteins in this genome belonging to this COG is 1","***** IPB000619 (Guanylate kinase) with a combined E-value of 2.4e-44. IPB000619A 8-25 IPB000619B 37-58 IPB000619C 60-112","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 15:02:41 2002","Fri Feb 8 14:54:56 2002","Fri Feb 8 15:02:41 2002","Fri Feb 8 14:54:56 2002","Fri Feb 8 14:54:56 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0432 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 15:02:41 2002","Fri Feb 8 14:54:56 2002","pdb|1GKY| Guanylate Kinase (E.C.2.7.4.8) Complex With Guanos... 135 5e-033","SMU.478","","Residues 41 to 145 (E-value = 1.8e-42) place SMu0432 in the Guanylate_kin family which is described as Guanylate kinase (PF00625)","Fri Feb 8 14:54:56 2002","24378963","","","Gentry D, Bengra C, Ikehara K, Cashel M.Guanylate kinase of Escherichia coli K-12.J Biol Chem. 1993 Jul 5;268(19):14316-21.PMID: 8390989","","Fri Feb 8 15:09:35 2002","1","","","SMU.478","522" "SMu0433","446542","446859","318","ATGATGTTAAAACCATCAATTGATACCTTGTTGGATAAGGTACCATCAAAATATTCGCTGGTTATTTTACAAGCTAAACGTGCACATGAACTTGAATCTGGAGCAACCCCAACTCAAGCCTTCACATCAGTTAAGCCAACTCTTCAAGCACTTGAAGAGATTGAAGCAGGTAATGTCGTTATTCACCCTGATCCAGAAGCTAAACGTGCAGCTGTGAGAGCTAGAGCTGAAGCTGAACGTATTGCGAAAGAAGAGGAAGAACGCAAAATTAAAGAACAAATTGCAAAAGAGAAGGAAGAAGAAGGTGAGAAAATCTAA","5.50","-2.51","11715","MMLKPSIDTLLDKVPSKYSLVILQAKRAHELESGATPTQAFTSVKPTLQALEEIEAGNVVIHPDPEAKRAAVRARAEAERIAKEEEERKIKEQIAKEKEEEGEKI","446856","For other 'rpo' genes see, SMu0086 (rpoE); Smu0746 (rpoD); Smu1817 (rpoA); SMu1807 (rpoB) and SMu1806 (rpoC). For DNA-directed RNA polymerase, delta subunit see SMu0086. For DNA-directed RNA polymerase, beta subunit see SMu1807. For DNA-directed RNA polymerase, beta' subunit see SMu1806. For DNA-directed RNA polymerase, alpha subunit see SMu1817. ","DNA-directed RNA polymerase, omega subunit","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and to RpoZ sequences. Residues 1-65 are 92% similar to gi15675506, a conserved hypothetical from S.pyogenes. Residues 2-65 are 82% similar to gi15675506, a predicted RpoZ from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0314 (1e-26).","

InterPro
IPR003716
Family

RNA polymerase, omega subunit
TIGR00690	$\"[2-66]T$	rpoZ
SSF63562	$\"[2-87]T$	RNA_pol_omega

InterPro
IPR006110
Family

RNA polymerase Rpb6
PF01192	$\"[13-65]T$	RNA_pol_Rpb6

noIPR
unintegrated

unintegrated
G3DSA:1.10.1480.10	$\"[2-88]T$	G3DSA:1.10.1480.10

","BeTs to 4 clades of COG1758COG name: RNA polymerase-associated protein RpoZ, omega subunitFunctional Class: KThe phylogenetic pattern of COG1758 is -----qv-ebrh--------xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 10:28:23 2006","Thu Mar 28 14:01:57 2002","Thu Sep 7 10:28:23 2006","Thu Mar 28 13:56:20 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0433 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 15:08:38 2002","","No significant hits to the NCBI PDB database.","SMU.479","","Residues 13 to 65 (E-value = 3.6e-14) place SMu0433 in the RNA_pol_Rpb6 family which is described as RNA polymerase Rpb6 (PF01192)","Fri Feb 8 15:03:44 2002","24378964","","","Kormanec J, Novakova R, Homerova D, Rezuchova B.Streptomyces aureofaciens sporulation-specific sigma factor sigma(rpoZ) directs expression of a gene encoding protein similar to hydrolases involved in degradation of the lignin-related biphenyl compounds.Res Microbiol. 2001 Dec;152(10):883-8.PMID: 11766963","","Fri Feb 8 15:11:19 2002","1","","","SMU.479","894" "SMu0434","446901","449285","2385","ATGACAAAAATTGCAAAGGTCATTGTAGATGTGCCCTTAATGCAAACAGATAAGCCCTTTTCTTATAAAATTCCAGAGGCATTATTATCAGTGATTACAGCAGGTTCACGTGTTCATGTTCCTTTTGGTAAAGGAAATCGATTATTACAAGGGTTTGTAGTAAGTGTAGATAGTGGATCAGCTCAGCATTTAAAAACAATTATTGACGTTTTAGATGTGGAACCGGTGCTTAATCAGGAGCAGTTGGAATTAGCAGATCAAATGCGTAAAACGGTTTTTTCTTATAAGATTTCTATTTTGAAATCAATGATTCCAAATCTCTTAAATTCTAATTATGATCGTTTGCTGAAACCTAAAAAAGGGCTATCTCAGGAAGAAAAGGACTTAATTTTTGCTGGTAAAAAACAGATAAATTTTTCGCAACTGAATCAAGAAATACAGACTAAAAGTTTAAGCTTGATACAGGCTGGTAAAATTGATATAGAATATTTAGCCAAGGATAGAAAGACAATTAAAACGCAAAAATGTTATGATGTTAATCTTGAAAAGTTATCTCATCTTCTTATCAATAAGCGAGCTAAAAAGCGGCAAGAACTGAAAGATTATCTTGCTAATCATCCGCAGTCCGGTCCTCTTTCGGATCTGTATCGGCTTTTTTCAAGAGAGGTTGTTCATTATTTTATAAAAGAAGCTGTTCTCAATATTTCACAAGTAGAAGTGAATCGTACCCAAAGCTATTTTGAAAATATTATTCAATCTGATTTTCTTGATTTAAACCCAGAACAGCAAACAGCAGTAGAGCAAATAACAGCTGCTATTGGTTCTTCTAATAAGCCTTATCTGCTTGAAGGAATTACAGGAAGCGGAAAAACAGAGGTTTATCTCCATGTTATTGATCAGACTTTGAAATTAGGTAAAACAGCCATTGTTCTAGTTCCTGAGATTTCGTTAACACCTCAGATGACTAGTCGCTTTATTTCTCGCTTTGGCAGTCAAGTTGCTATCATGCATTCGGGCTTGTCTGATGGTGAAAAATTCGATGAGTGGCGTAAAATGAAATCCAATCAAGCTAAAGTTGTTGTTGGAGCGCGCTCAGCTATTTTCTCTCCTTTAAAAAATATTGGTGCTATCATTATTGATGAAGAGCACGAGGCAACTTATAAACAAGAGTCTAGTCCACGCTATCATGCGCGGGAGGTGGCACTATTGCGTGCCCAATATCATCAGGCAGTTTTAGTCTTAGGCAGTGCGACGCCATCTATTGAGAGCCGAGCGCGAGCCAGCCGTGGTGTTTATAACTTCCTGCAGCTAAGTCAAAGGGCCAATCCTCAAGCACACATTCCCAAGGTAAAAATTGTAGATTTTCGTGATTATATCGGTCAGCAAAAAGTGAGTAATTTAACACCTGTTCTGCTAGATAAAATTAAAGATCGTCTAATAAAAAAGGAACAGGTCGTTCTTATGCTTAATCGTCGCGGGTATTCTAGTTTTATTATGTGCCGTGACTGCGGTTATGTTGATAACTGTCCTAATTGTGATATCTCCTTAACTTTACACATGGATACCAAAACAATGAATTGTCACTATTGTGGCTTTTTAAAAGGAATTCCTTACAACTGTCCTAATTGTCAAAGTCGGCAAATTCGTTATTATGGAACGGGAACGCAAAAAGCTTATGATGAATTAAAACAAGTTTTGCCAGAAGCACGCATTTTACGGATGGATGTTGATACAACCAAAAGAAAGGGAGCGCATGAGAAGATTCTGACGAAATTTGGTCGTCATGAAGCTGATATTCTTTTAGGAACGCAAATGATTGCCAAAGGACTTGATTTTCCTAATGTTACTTTGGTTGGTGTATTAAATGCAGATACTTCACTTAATTTGCCGGATTTTCGCTCAAGTGAGCGTACTTTTCAACTTTTAACACAGGTGGCAGGACGCGCAGGCCGTGCAAATAAACCGGGTGAGGTTTTGATTCAAACCTATAATCCTAATCATTATGCTATTCAGTTGGCAAGGGAACAGGACTATGAAGCTTTTTATCGCTACGAAATGAGAATTCGTAAGGCACTTTCCTACCCACCCTACTATTTCACAGTTGGCTTAACTCTATCACATAAAGATGAGCAAGAGGTTATCAAAAAATCTTATGAGATAGTGACGTTGATCAAGGAAGGACTGACAGATAAGATTAAAATATTGGGTCCAACACCCAAACCTGTCGCTAGGACGCATAATCTTTATCATTATCAAATTATCATTAAGTATCGTTTTGAAGACCAGTTGGAGATTGTTTTAAATCATATTTTAGATTTAACTCAAGCTAAAGAAAATAAAAAGTTACGTTTGATTATTGATCATGAGCCACAAAGTTTTATGTAA","10.00","28.69","90479","MTKIAKVIVDVPLMQTDKPFSYKIPEALLSVITAGSRVHVPFGKGNRLLQGFVVSVDSGSAQHLKTIIDVLDVEPVLNQEQLELADQMRKTVFSYKISILKSMIPNLLNSNYDRLLKPKKGLSQEEKDLIFAGKKQINFSQLNQEIQTKSLSLIQAGKIDIEYLAKDRKTIKTQKCYDVNLEKLSHLLINKRAKKRQELKDYLANHPQSGPLSDLYRLFSREVVHYFIKEAVLNISQVEVNRTQSYFENIIQSDFLDLNPEQQTAVEQITAAIGSSNKPYLLEGITGSGKTEVYLHVIDQTLKLGKTAIVLVPEISLTPQMTSRFISRFGSQVAIMHSGLSDGEKFDEWRKMKSNQAKVVVGARSAIFSPLKNIGAIIIDEEHEATYKQESSPRYHAREVALLRAQYHQAVLVLGSATPSIESRARASRGVYNFLQLSQRANPQAHIPKVKIVDFRDYIGQQKVSNLTPVLLDKIKDRLIKKEQVVLMLNRRGYSSFIMCRDCGYVDNCPNCDISLTLHMDTKTMNCHYCGFLKGIPYNCPNCQSRQIRYYGTGTQKAYDELKQVLPEARILRMDVDTTKRKGAHEKILTKFGRHEADILLGTQMIAKGLDFPNVTLVGVLNADTSLNLPDFRSSERTFQLLTQVAGRAGRANKPGEVLIQTYNPNHYAIQLAREQDYEAFYRYEMRIRKALSYPPYYFTVGLTLSHKDEQEVIKKSYEIVTLIKEGLTDKIKILGPTPKPVARTHNLYHYQIIIKYRFEDQLEIVLNHILDLTQAKENKKLRLIIDHEPQSFM","449282","","primosomal replication factor Y (primosomal protein N')","Cytoplasm","Matches in gapped BLAST to primosomal replication factor Y sequences. Residues 1-794 are 69% similar to gi15675505 from S.pyogenes. Residues 4-794 are 64% similar to gi15901568 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0315 (0.0).","

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[586-653]T$	Helicase_C
SM00490	$\"[556-653]T$	HELICc
PS51194	$\"[535-692]T$	HELICASE_CTER

InterPro
IPR005259
Family

Primosomal protein n
TIGR00595	$\"[281-791]T$	priA

InterPro
IPR006935
Family

Type III restriction enzyme, res subunit
PF04851	$\"[255-421]T$	ResIII

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[254-450]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[271-437]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[237-447]T$ $\"[553-686]T$	G3DSA:3.40.50.300
PTHR10967	$\"[589-656]T$	PTHR10967
PTHR10967:SF53	$\"[589-656]T$	PTHR10967:SF53
SSF52540	$\"[250-437]T$ $\"[520-700]T$	SSF52540

","BeTs to 11 clades of COG1198COG name: Primosomal protein N' (replication factor Y) - superfamily II helicaseFunctional Class: LThe phylogenetic pattern of COG1198 is -----qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 15:21:41 2002","Thu Jul 20 11:05:15 2006","Thu Jul 20 11:05:15 2006","Thu Jul 20 11:05:15 2006","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0434 is paralogously related (blast p-value < 1e-3) to SMu0006, a predicted transcription-repair coupling factor, to SMu0415, an ATP-dependent helicase, to SMu0734, a predicted excinuclease ABC (subunit B), and to SMu1669, an ATP-dependent helicase.","Fri Feb 8 15:25:06 2002","","No significant hits to the NCBI PDB database.","SMU.480","","Residues 248 to 448 (E-value = 1.2e-05) place SMu0434 in the DEAD family which is described as DEAD/DEAH box helicase (PF00270)Residues 563 to 653 (E-value = 1.1e-07) place SMu0434 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)","Thu Jul 20 11:05:15 2006","24378965","","","Bruand C, Farache M, McGovern S, Ehrlich SD, Polard P.DnaB, DnaD and DnaI proteins are components of the Bacillus subtilis replication restart primosome.Mol Microbiol. 2001 Oct;42(1):245-55.PMID: 11679082 Marsin S, McGovern S, Ehrlich SD, Bruand C, Polard P.Early steps of Bacillus subtilis primosome assembly.J Biol Chem. 2001 Dec 7;276(49):45818-25.PMID: 11585815Masai H, Deneke J, Furui Y, Tanaka T, Arai KI.Escherichia coli and Bacillus subtilis PriA proteins essential for recombination-dependent DNA replication: involvement ofATPase/helicase activity of PriA for inducible stable DNA replication.Biochimie. 1999 Aug-Sep;81(8-9):847-57.PMID: 10572298 25: Marians KJ. Related Articles PriA: at the crossroads of DNA replication and recombination. Prog Nucleic Acid Res Mol Biol. 1999;63:39-67. Review. PMID: 10506828","","Fri Feb 8 15:21:41 2002","1","","","SMU.480","40" "SMu0435","449333","450280","948","ATGAGGTTACAAATGACAAAATTAATTTTTATGGGGACACCTGATTTTTCAGCAACTGTTCTCAAAGGTTTACTAGAGGACAGTCATTATCATGTCTTAGCAGTTGTTACACAGCCAGATCGTGCTGTTGGTCGTAAAAAAGAAATTAAGATGACACCTGTTAAACAACTTGCTTTAGAACATGGTTTAAAGGTTTATCAGCCTGAGAAGTTATCAGGTTCATCGGAAATGGTAGAATTAATGAATTTGGGTGCTGATGGTATTGTGACAGCTGCCTTTGGTCAATTTTTACCAATGATATTGATTAATTCTGTTGATTTTGCTGTCAACGTTCACGCATCCTTGCTTCCTAAATATCGCGGTGGGGCACCTATTCATTATGCTATTATCAATGGAGATAAGAAAGCTGGCGTAACCATCATGGAAATGGTCAAAGAGATGGACGCTGGGGATATGATTGCAAAGGCTTCAACACCAATTACGGATGCAGATGATGTTGGTACGATGTTTGAAAAGTTAGCTATCATTGGGCGTGACTTACTTTTGCAGACTCTTCCAGGCTATCTGTCTGGTAAAATTGAGCCACAGGCTCAGGATGATAGTCAAGCAACTTTTTCTCCTAATATCAGTTCTCAAGAAGAAAAAATTGATTGGAGCAAATCTGCCCGAGATATTTTCAATCAAGTCCGTGGTATGAATCCTTGGCCAGTTGCTCACACTCTGCTTGATGGTAAACGTTTTAAAATTTATGCTGTTGAAGTCGTTAATGGGGCTGGAAATCCGGGAGAAATCATTGAAAAAACGAAGAAAGCTTTGATTGTAGCTGCAAACCAAGATGCTTTATCATTAAAATTGGTTCAGCCTGCTGGAAAACCTAAAATGTCTATCACTGACTTTTTAAACGGCCTAGGTCAAAAACTTAAAGTGGGTGATTATTTTGGGAAATAA","8.80","2.45","34283","MRLQMTKLIFMGTPDFSATVLKGLLEDSHYHVLAVVTQPDRAVGRKKEIKMTPVKQLALEHGLKVYQPEKLSGSSEMVELMNLGADGIVTAAFGQFLPMILINSVDFAVNVHASLLPKYRGGAPIHYAIINGDKKAGVTIMEMVKEMDAGDMIAKASTPITDADDVGTMFEKLAIIGRDLLLQTLPGYLSGKIEPQAQDDSQATFSPNISSQEEKIDWSKSARDIFNQVRGMNPWPVAHTLLDGKRFKIYAVEVVNGAGNPGEIIEKTKKALIVAANQDALSLKLVQPAGKPKMSITDFLNGLGQKLKVGDYFGK","450277","","methionyl-tRNA formyltransferase","Cytoplasm, Periplasm","Matches in gapped BLAST to Methionyl-tRNA formyltransferases. Residues 5-315 are 72% similar to gi|15675504 from S.pyogenes. Residues 1-314 are 72% similar to gi|15903622 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0316 (1e-131).","

InterPro
IPR001555
Active_site

Phosphoribosylglycinamide formyltransferase, active site
PS00373	$\"[137-160]T$	GART

InterPro
IPR002376
Domain

Formyl transferase, N-terminal
G3DSA:3.40.50.170	$\"[3-210]T$	no description
PF00551	$\"[6-185]T$	Formyl_trans_N

InterPro
IPR005793
Domain

Formyl transferase, C-terminal
PF02911	$\"[210-304]T$	Formyl_trans_C

InterPro
IPR005794
Family

Methionyl-tRNA formyltransferase
TIGR00460	$\"[6-314]T$	fmt: methionyl-tRNA formyltransferase

InterPro
IPR015518
Family

Methionine tRNA Formyltransferase-like
PTHR11138	$\"[71-303]T$	METHIONYL-TRNA FORMYLTRANSFERASE

noIPR
unintegrated

unintegrated
G3DSA:3.10.25.10	$\"[211-314]T$	no description

","BeTs to 13 clades of COG0223COG name: Methionyl-tRNA formyltransferaseFunctional Class:� JThe phylogenetic pattern of COG0223 is ----yQvcEbRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001555 (Phosphoribosylglycinamide formyltransferase active site) with a combined E-value of 2.6e-06. IPB001555 109-121","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 15:34:42 2002","Fri Feb 8 15:26:06 2002","Fri Feb 8 15:34:42 2002","Fri Feb 8 15:26:06 2002","Fri Feb 8 15:26:06 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0435 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 15:34:42 2002","Fri Feb 8 15:26:06 2002","pdb|2FMT|A Chain A, Methionyl-Trnafmet Formyltransferase Comple... 226 3e-060","SMU.481","","Residues 6 to 185 (E-value = 3.3e-39) place SMu0435 in the Formyl_trans_N family which is described as Formyl transferase (PF00551)Residues 210 to 304 (E-value = 4.4e-31) place SMu0435 in the Formyl_trans_C family which is described as Formyl transferase, C-terminal domain (PF02911)","Fri Feb 8 15:26:06 2002","24378966","","","Margolis P, Hackbarth C, Lopez S, Maniar M, Wang W, Yuan Z, White R, Trias J.Resistance of Streptococcus pneumoniae to deformylase inhibitors is due to mutations in defB.Antimicrob Agents Chemother. 2001 Sep;45(9):2432-5.PMID: 11502510Komatsuzawa H, Ohta K, Labischinski H, Sugai M, Suginaka H.Characterization of fmtA, a gene that modulates the expression of methicillin resistance in Staphylococcus aureus.Antimicrob Agents Chemother. 1999 Sep;43(9):2121-5.PMID: 10471551","","Fri Feb 8 15:34:42 2002","1","","","SMU.481","259" "SMu0436","450270","451583","1314","TTGGGAAATAAGCAACCAACTGCACGTAGTGGTGCCCTTTTTGTCTTAACTGAAATTTTTGATAAGACTGCCTATAGCAATATCGCTTTAAGGCACTATTTAAGCAAGCACAAACTTTCTCAGGCTGATAGATCCTTACTGACTGAGCTCGTTTATGGGACCTTGACTCGCAAGATTACCTTGGAATGGTATCTTGCTCATTATATTGAAGATCGCAATAAATTAGAAACTTGGATCTATTATTTACTAATGCTTAGCCTTTATCAAATTCTTTATTTAGATAAAATTCCTCAGCATGCTATTGTTAATGAAGCTGTTGATCTGGCAAAAAGCAGAAATAGAGGTGCTGAAAAGTTAGTCAATGCTGTGTTAAGGCAGTTTTTACGCCAAAAAAGACCTGACATAACTGTCATTAAACGAAAAAATAAACGTTATTCCATCACCTATTCTGTACCAGTTTGGCTAGTTAAAAAAATGATTGACCAATTCGGTGAAGATAGGGCAATCAGCATTTTGAAAAGTCTTTTAGTTCGAAGTAAGGCTAGTATTCGTGTGGTTAATCCTGATCAAATAGAAGTGATAGCAAAAGCAACAGGAGCCAAAAAATCGGTTTTATCACCTTGTGGTCTGGTCAAAGCATCAGGTCAGTTTTTTGATAGTGATTTATTTAAACAGGGAAAGATCACCATTCAAGATGAGAGCAGTCAGTTAGTAGCGCCCACTTTAGCTATTAAAGGAAATGAGACTGTTCTAGATGCTTGCAGTGCCCCCGGGGGAAAAGCTGTCCATATAGCTTCTTATTTGACGACAGGCCAGATTATAGCACTTGACTTGTATGATCATAAACTAAAATTAATCAAAGATAATGCAGACCGTCTAAAAGCCGCCAATTATATAAAGCCGCAAAAATTAGATGCTAGAAAAGTCCATAAATACTTTGCTAAGGATACATTTGATAAAATTTTAGTTGATGCTCCTTGTTCAGGAATTGGCTTGATTAGGCGTAAACCAGATATTAAGTATAATAAGGATAGTAAGGATTTTACCAGCTTACAAAAAATTCAGTTAGAGATTTTAGATAGTGTTTGCCAAACTATAAAAAAAGGTGGTATAATAACATACAGCACATGTACTATTTTTGCTGAAGAGAATCAGATGGTACTTAAACAATTTTTGGAACAGCATCCAAATTTTGAACAGGTAAAATTAAATCATAAAAAGAAAGATATTGTCGTTGATGGTTGTCTTCTTATTACACCTGAACAATATCTAACAGACGGTTTTTTTATCAGCCAAGTTAAGCGTATTTCGTAA","10.30","24.89","49584","MGNKQPTARSGALFVLTEIFDKTAYSNIALRHYLSKHKLSQADRSLLTELVYGTLTRKITLEWYLAHYIEDRNKLETWIYYLLMLSLYQILYLDKIPQHAIVNEAVDLAKSRNRGAEKLVNAVLRQFLRQKRPDITVIKRKNKRYSITYSVPVWLVKKMIDQFGEDRAISILKSLLVRSKASIRVVNPDQIEVIAKATGAKKSVLSPCGLVKASGQFFDSDLFKQGKITIQDESSQLVAPTLAIKGNETVLDACSAPGGKAVHIASYLTTGQIIALDLYDHKLKLIKDNADRLKAANYIKPQKLDARKVHKYFAKDTFDKILVDAPCSGIGLIRRKPDIKYNKDSKDFTSLQKIQLEILDSVCQTIKKGGIITYSTCTIFAEENQMVLKQFLEQHPNFEQVKLNHKKKDIVVDGCLLITPEQYLTDGFFISQVKRIS","451580","","RNA-binding Sun protein; possible rRNA methylase","Cytoplasm","Matches in gapped BLAST to SUN family RNA binding proteins. Residues 3-436 are 63% similar to gi15675503 from S.pyogenes. Residues 4-437 are 63% similar to gi15903621 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0317 (1e-153).","

InterPro
IPR001678
Domain

Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p
PF01189	$\"[223-434]T$	Nol1_Nop2_Fmu
PS01153	$\"[318-329]T$	NOL1_NOP2_SUN

InterPro
IPR004573
Family

Fmu, rRNA SAM-dependent methyltransferase
TIGR00563	$\"[9-437]T$	rsmB: ribosomal RNA small subunit methyltra

InterPro
IPR006027
Domain

NusB/RsmB/TIM44
G3DSA:1.10.940.10	$\"[2-147]T$	no description
PF01029	$\"[6-131]T$	NusB

InterPro
IPR006174
Domain

rRNA subunit methyltransferase
PD005242	$\"[200-238]T$	Q82ZD9_ENTFA_Q82ZD9;

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[231-435]T$	no description
PTHR22807	$\"[210-435]T$	NOP2(YEAST)-RELATED NOL1/NOP2/FMU(SUN) DOMAIN-CONTAINING
PTHR22807:SF12	$\"[210-435]T$	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE B (SUN)

","BeTs to 10 clades of COG0144COG name: Predicted rRNA methylaseFunctional Class: JThe phylogenetic pattern of COG0144 is Am-KY-vcEbrh------in-Number of proteins in this genome belonging to this COG is 2","***** IPB001678 (NOL1/NOP2/sun family) with a combined E-value of 6.9e-48. IPB001678A 231-242 IPB001678B 250-264 IPB001678C 271-294 IPB001678D 318-335 IPB001678E 367-393 IPB001678F 419-435","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 15:40:15 2002","Fri Feb 8 15:35:51 2002","Wed Sep 6 16:16:02 2006","Tue Feb 12 09:19:54 2002","Fri Feb 8 15:35:51 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0436 is paralogously related (blast p-value < 1e-3) to SMu1041, a predicted conserved hypothetical protein;possible nucleolar protein, and to SMu1680, a predicted transcription termination factor.","Tue Feb 12 09:19:54 2002","","No significant hits to the NCBI PDB database.","SMU.482","","Residues 6 to 131 (E-value = 5.5e-29) place SMu0436 in the NusB family which is described as NusB family (PF01029)Residues 171 to 434 (E-value = 1.5e-38) place SMu0436 in the Nol1_Nop2_Sun family which is described as NOL1/NOP2/sun family (PF01189)","Wed Sep 6 16:16:02 2006","24378967","","","","","","1","","","SMU.482","260" "SMu0437","451622","452365","744","ATGAAAATTTCCCTTTTTACAGATATTGGACAGAAGCGTTCTAATAATCAAGATTTTATCAATAAATTTGATAATCGTGCGGGGCATACACTGATTGTATTGGCAGATGGCATGGGCGGTCATCGTGCTGGAAATATAGCCAGTGAGATGACCGTTACTGATTTGGGGCGCGAATGGATTAATACAGACTTAACGGACTTAGGACAAATTCGTGATTGGCTGGTTAATAATATCGAAAAAGTTAATCGTCGGATTTATGAATTGGGTCAAACAGATGATTTTCAAGGTATGGGGACAACTATTGAAGCCTTAGTTATCATTGAAAATAATGTTCTTTTTGCTCATATTGGTGATTCACGAATTAGTTTAATTCACGATGGGGTTTATACGCAATTGACTAGTGATCACTCTCTAGTCAATGAATTAGTTAAGGCTGGCCAAATAACAGAAGAAGAGGCTGCTAGCCACCCTCAAAAAAATATTATCACACAATCTATTGGACAAGCTAGTCCAGTTGAACCAGATCTTGGTATTCAAACCTTAGGAGCAAATGATTATCTTTTAGTTAATAGTGATGGTTTGACGAATATGATTTCGAATGAAGCTATTGTTGCTGTTCTAACTGATGAAACAAAGGACTTAGATGAAAAAGCCAAGCATTTGATTCAATTAGCTAATGATGCAGGTGGGCTTGACAATATCACTGTAGCCTTAATTCACGCCGAAAGTGAGGGAGATCAATGA","4.40","-19.06","26956","MKISLFTDIGQKRSNNQDFINKFDNRAGHTLIVLADGMGGHRAGNIASEMTVTDLGREWINTDLTDLGQIRDWLVNNIEKVNRRIYELGQTDDFQGMGTTIEALVIIENNVLFAHIGDSRISLIHDGVYTQLTSDHSLVNELVKAGQITEEEAASHPQKNIITQSIGQASPVEPDLGIQTLGANDYLLVNSDGLTNMISNEAIVAVLTDETKDLDEKAKHLIQLANDAGGLDNITVALIHAESEGDQ","452362","","phosphoprotein phosphatase (pppL protein)","Cytoplasm","Matches in gapped BLAST to phosphoprotein phosphatases. Residues 1-244 are 73% similar to gi15675502 from S.pyogenes and 59% similar to gi15901565 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0318 (6e-99).","

InterPro
IPR001932
Domain

Protein phosphatase 2C-related
SM00331	$\"[7-241]T$	PP2C_SIG
SM00332	$\"[1-239]T$	PP2Cc

InterPro
IPR014045
Domain

Protein phosphatase 2C-like
PF00481	$\"[1-234]T$	PP2C

noIPR
unintegrated

unintegrated
G3DSA:3.60.40.10	$\"[1-243]T$	G3DSA:3.60.40.10
PTHR13832	$\"[78-239]T$	PTHR13832
SSF81606	$\"[1-246]T$	SSF81606

","BeTs to 7 clades of COG0631COG name: Protein serine/threonine phosphatasesFunctional Class: TThe phylogenetic pattern of COG0631 is ----YQ-C-br---gp--in-Number of proteins in this genome belonging to this COG is 1","***** IPB000222 (Protein phosphatase 2C subfamily) with a combined E-value of 4.1e-08. IPB000222E 110-128 IPB000222H 184-196 IPB000222I 230-239","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 15:50:35 2002","Fri Feb 8 15:43:47 2002","Wed Aug 23 13:25:09 2006","Wed Aug 23 13:25:09 2006","Fri Feb 8 15:43:47 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0437 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 15:50:35 2002","","No significant hits to the NCBI PDB database.","SMU.483","","Residues 3 to 234 (E-value = 3.9e-07) place SMu0437 in the PP2C family which is described as Protein phosphatase 2C (PF00481)","Fri Feb 8 15:43:47 2002","24378968","","","","","","1","","","SMU.483","523" "SMu0438","452362","454212","1851","ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATTCTCCAGTCTATCGGACGAGGTGGGATGGCGGATGTTTATTTAGCTAATGATTTGATTTTAGATAATGAGGAAGTGGCCATTAAGGTTCTACGTACGAATTATCAGACAGATCAGGTTGCTGTGACACGTTTTCAGCGGGAAGCACGTGCCATGGCAGAACTTAATCATCCTAATATTGTAGCCATTCGTGACATTGGAGAAGAAGACGGTCAGCAATTCCTTGCAATGGAATATGTTGATGGCGCCGACTTGAAGAAATACATTCAAGATCACGCTCCTTTATCAAATGCTGAAGTCATTAGAATCATGAAAGAGGTTCTTTCTGCTATGACTCTTGCCCACCAAAAGGGCATTATTCATCGGGATTTAAAACCTCAAAATGTTTTACTGACCAAAGATGGAACGGCTAAAGTAACAGACTTTGGTATTGCTGTGGCTTTTGCTGAAACGAGTTTGACCCAAACCAATTCAATGCTGGGTTCAGTACATTACTTATCTCCTGAACAGGCGCGTGGTTCTAAGGCTACTGTTCAAAGTGATATCTATGCAATGGGGATTATGCTTTTTGAAATGCTGACAGGGCATATTCCCTATGATGGCGATAGTGCTGTTACAATTGCTTTGCAGCATTTTCAAAAGCCTTTACCATCTATTATTGCTGAGAATAAAAATGTCCCTCAAGCTCTTGAAAATGTTGTTATTAAAGCAACAGCTAAACGATTAACGGACCGCTATCATTCAACGCAGGAGATGTTGCAGGATTTAAGAACGTCTCTGCAGCCGAATCGCAGCCGTGAAAGAAAGCTTGTTTTCAGTGATGCTTCAGATACAAAACCACTACCAAAACTGGAACAGGCAGCAGCAAACTCTTTAGCTGCTCAGTCCTTAAAAAACAAAACTTCCAATCAGGATAAAGTAGATCATAAATCTAAGCCTAAAACCAAACCACAACCTAAGCCTAAGAAAAAAAGACATTTTTTAGCTCGTTTCTTTAAAATCTTCTTTATATTAGTTGCCATTGGTATTGCTGTTTTGACCTACCTGGTTCTGACAAAACCGAGTACTGTTTCAGTTCCTGACGTTTCAGGAGATAAATTATCAACGGCCAAGATGATTATTAGAAAATCGGGTCTTAAGGTGGGTGACGTTCAAAAAATTGAGGATGATAACGTTGGTGCTGGAAAGGTCGTAAGAACTAATCCAAGTGCAGGCAGTAAAAAACGTGAAGGTTCTAGTGTTGATATTTTTGTAGCTAGTGCTAAGGGATTTAAGATGGAGGACTATACCGGTCAAGATTACAAGGATGCTATTGATAATCTGACTAATAATTATGGTGTTTCTAGGGACAGTATTGTTCTTAAGGAAGTTTCATCTGATGACTACAGTGGTGGAACTGTTATCGGTCAATCACCAAAACCCGGAAAGACCTATCATCCTAGCAGTGATAAAAAAATAACTCTCAAGGTTGTCAAAGTCACTATGCCAAATCTTAAAAATTCTACTTATGAAGAGGCTGTCAGTACTTTAACAGCTATGGGGATTTCTTCAAGCCGTATAAAAGCTTATGATGCCAGCGATTACTCATCAGAAATTTCATCACCATCATCTTCGTCACTCGTTGTCGGTCAAAGTCCTTATTATGGTAATACTGTCAGTCTGTCATCTAATGATGATATTATCTTGTATGTTTCAACATCAGGTGGCTCTCATTCTGGTTCGTCGTCGTCTGAATCTTCGAACAGTGAAGGAACAACATCAAGCGAAGCCTCGACAGACTCTAGTTCAAGTGCGACGACAACTTCACATTAA","9.80","10.17","66905","MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIGEEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVAFAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENKNVPQALENVVIKATAKRLTDRYHSTQEMLQDLRTSLQPNRSRERKLVFSDASDTKPLPKLEQAAANSLAAQSLKNKTSNQDKVDHKSKPKTKPQPKPKKKRHFLARFFKIFFILVAIGIAVLTYLVLTKPSTVSVPDVSGDKLSTAKMIIRKSGLKVGDVQKIEDDNVGAGKVVRTNPSAGSKKREGSSVDIFVASAKGFKMEDYTGQDYKDAIDNLTNNYGVSRDSIVLKEVSSDDYSGGTVIGQSPKPGKTYHPSSDKKITLKVVKVTMPNLKNSTYEEAVSTLTAMGISSSRIKAYDASDYSSEISSPSSSSLVVGQSPYYGNTVSLSSNDDIILYVSTSGGSHSGSSSSESSNSEGTTSSEASTDSSSSATTTSH","454209","","serine/threonine protein kinase","Membrane, Periplasm","Matches in gapped BLAST to protein kinases. Residues 1-577 are 63% similar to gi15675501 from S.pyogenes and 51% similar to gi15901564, a predicted serine/threonine kinase from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0319 (0.0).","

InterPro
IPR000719
Domain

Protein kinase
PD000001	$\"[12-273]T$	Prot_kinase
PF00069	$\"[12-219]T$	Pkinase
PS00107	$\"[18-42]?$	PROTEIN_KINASE_ATP
PS50011	$\"[12-273]T$	PROTEIN_KINASE_DOM

InterPro
IPR005543
Domain

PASTA
PF03793	$\"[370-433]T$ $\"[437-505]T$ $\"[506-579]T$	PASTA
SM00740	$\"[366-433]T$ $\"[434-505]T$ $\"[506-579]T$	PASTA
PS51178	$\"[366-433]T$ $\"[435-501]T$ $\"[502-579]T$	PASTA

InterPro
IPR008271
Active_site

Serine/threonine protein kinase, active site
PS00108	$\"[132-144]T$	PROTEIN_KINASE_ST

InterPro
IPR011009
Domain

Protein kinase-like
SSF56112	$\"[1-271]T$	Kinase_like

noIPR
unintegrated

unintegrated
G3DSA:1.10.510.10	$\"[65-290]T$	G3DSA:1.10.510.10
PTHR22986	$\"[11-338]T$	PTHR22986
SSF54184	$\"[369-433]T$	SSF54184

","BeTs to 8 clades of COG0515COG name: Serine/threonine protein kinasesFunctional Class: TThe phylogenetic pattern of COG0515 is amtkYq-C-BR---gp-lIN-Number of proteins in this genome belonging to this COG is 1","***** IPB000961 (Protein kinase C-terminal domain) with a combined E-value of 1e-29. IPB000961A 11-45 IPB000961B 71-102 IPB000961C 126-160 IPB000961D 171-212***** IPB001245 (Tyrosine kinase catalytic domain) with a combined E-value of 2.6e-29. IPB001245A 119-159 IPB001245B 175-213***** IPB001772 (Kinase associated domain 1) with a combined E-value of 4.6e-24. IPB001772A 9-40 IPB001772B 68-113 IPB001772C 114-144 IPB001772D 182-221***** IPB000095 (PAK-box /P21-Rho-binding) with a combined E-value of 2.4e-18. IPB000095C 42-78 IPB000095D 86-100 IPB000095E 127-172 IPB000095F 179-233***** IPB000861 (PKN/rhophilin/rhotekin rho-binding repeat) with a combined E-value of 1.8e-14. IPB000861E 58-103 IPB000861F 120-174 IPB000861G 177-226***** IPB003527 (MAP kinase) with a combined E-value of 1.4e-11. IPB003527C 111-159 IPB003527D 168-209***** IPB000494 (Epidermal growth-factor receptor (EGFR), L domain) with a combined E-value of 5.7e-10. IPB000494C 113-159 IPB000494D 172-221***** IPB000959 (POLO box duplicated region) with a combined E-value of 1.3e-06. IPB000959A 12-24 IPB000959B 103-143 IPB000959C 150-202","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 15:54:23 2002","Tue Jan 18 15:05:39 2005","Tue Jan 18 15:05:39 2005","Tue Oct 8 09:33:10 2002","Fri Feb 8 15:51:40 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0438 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 8 15:54:23 2002","Tue Jan 18 15:05:39 2005","pdb1B38A Chain A, Human Cyclin-Dependent Kinase 2 >gi4139570... 106 6e-024pdb1DM2A Chain A, Human Cyclin-Dependent Kinase 2 Complexed W... 106 6e-024pdb1QMZA Chain A, Phosphorylated Cdk2-Cyclyin A-Substrate Pep... 104 2e-023","SMU.484","","Residues 12 to 269 (E-value = 1.4e-60) place SMu0438 in the Pkinase family which is described as Protein kinase domain (PF00069)Residues 368 to 433 (E-value = 3.1e-13) place SMu0438 in the PASTA family which is described as PASTA domain (PF03793)Residues 435 to 503 (E-value = 4.1e-13) place SMu0438 in the PASTA family which is described as PASTA domain (PF03793)Residues 504 to 579 (E-value = 8.6e-08) place SMu0438 in the PASTA family which is described as PASTA domain (PF03793)","Tue Jan 18 15:05:39 2005","24378969","","Hussain H, Branny P, Allan E.A eukaryotic-type serine/threonine protein kinase is required for biofilm formation, genetic competence, and acid resistance in Streptococcus mutans.J Bacteriol. 2006 Feb;188(4):1628-32.PMID: 16452447","Av-Gay Y, Jamil S, Drews SJ.Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB.Infect Immun. 1999 Nov;67(11):5676-82.PMID: 10531215","Tue Apr 24 12:51:14 2007","Fri Feb 8 15:56:24 2002","1","","","SMU.484","41" "SMu0439","454530","455348","819","ATGGCGTCTTTGATATTTGAAAAATTCTCTTTATCTTTAGTGTTATTTGGTCTAGATCAAGAGGTGAAATTTATCCTAAATTTTGATACAATGACTAATAATTGTAGAACTGAAGGAAGCCTTATGCGAAAATTTCAATTTTTTTTGGTTGTTGAAACCATCTTAATTGCTTTAGCTTTTATGACTATTCTGGCGAGTAATCTCTCAAGTTTTATCTTGATTGTGGTTATTACTCTTTTAGCCTTGAGATTTTATCGTTTAGGCAGTCGAAATGACTTTTTATTGACAGCTAGTTTACTTTTACTTTTTCTTATTTTTATGCTCAATCCTTATACAATTGCTGCGGTACTTGTTGGAATCCTTTATGTTATGATTAATCATTTTGCTCAAGTCAAAAAGAAGAATCGCTACGCTTTATTAACCTTGCAAGAAGAAGGTTTAGATGTGACTAAAAAACCACATCAGTGGATTGGTAATGATGAACATGTGGAAACAGATACCTATGCTTTTGATGATATCAATGTTATTCGTCTTAGCGGAAGTGATGTGATTAATCTCAGTCAGGTCATTGTAAGTGAACAAAATAATGTGGTCATGATTCGTAAAGTTTACGGACCTACCAAGATTTTAGTTCCTGTTGATGTCTCAGTTAGTTTGGATGTTAGCAGCATCTATGGCTATGTTCGCTTTTTTGATGCACCAGAATATGATTTGCGCAATGAGGAAATTAGACTGTCTGATCATATAGATGGAAGAACCAAATCTGTAAAAATTATCATCAATGTCATTGCGGGCTTGGTGGAGGTAGAACGTATATGA","5.80","-3.08","30926","MASLIFEKFSLSLVLFGLDQEVKFILNFDTMTNNCRTEGSLMRKFQFFLVVETILIALAFMTILASNLSSFILIVVITLLALRFYRLGSRNDFLLTASLLLLFLIFMLNPYTIAAVLVGILYVMINHFAQVKKKNRYALLTLQEEGLDVTKKPHQWIGNDEHVETDTYAFDDINVIRLSGSDVINLSQVIVSEQNNVVMIRKVYGPTKILVPVDVSVSLDVSSIYGYVRFFDAPEYDLRNEEIRLSDHIDGRTKSVKIIINVIAGLVEVERI","455345","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 36-247 are 49% similar to gi|15675500 from S.pyogenes. Residues 42-271 are 31% similar to gi|15902386 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0320 (5e-58).","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[23-204]T$	no description

noIPR
unintegrated

unintegrated
signalp	$\"[1-20]?$	signal-peptide
tmhmm	$\"[40-60]?$ $\"[66-85]?$ $\"[87-107]?$ $\"[113-131]?$	transmembrane_regions

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[219-327]T$	ATP_bd_ATPase
PF02518	$\"[236-328]T$	HATPase_c
SM00387	$\"[236-329]T$	HATPase_c
SSF55874	$\"[199-327]T$	ATP_bd_ATPase

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[135-329]T$	HIS_KIN

InterPro
IPR011712
Domain

Histidine kinase, dimerisation and phosphoacceptor region
PF07730	$\"[132-200]T$	HisKA_3

","BeTs to 8 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 16:26:59 2002","Wed Aug 23 15:54:54 2006","Wed Aug 23 15:54:54 2006","Wed Aug 23 15:54:54 2006","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0440 is paralogously related (blast p-value < 1e-3) to SMu1783, SMu1407, and SMu0946, all predicted histidine kinases.","Fri Feb 8 16:26:59 2002","","No significant hits to the NCBI PDB database.","SMU.486","","Residues 236 to 328 (E-value = 1e-09) place SMu0440 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Mon Jan 7 16:51:10 2002","24378971","","","Grebe TW, Stock JB.The histidine protein kinase superfamily.Adv Microb Physiol. 1999;41:139-227. Review.PMID: 10500846Alex LA, Simon MI.Protein histidine kinases and signal transduction in prokaryotes and eukaryotes.Trends Genet. 1994 Apr;10(4):133-8. Review.PMID: 8029829","","Fri Feb 8 16:25:53 2002","1","","","SMU.486","524" "SMu0441","456336","456983","648","ATGCTGATGAGTAAAACAAAAGTTATACTGGTTGATGATCATGAAATGGTTCGATTGGGTTTGAAAAGTTTTCTTAATTTACAAGATAATGTAGAAGTTATCGGTGAGGCTAGCAATGGCCGTCAAGGTATTGACTTGGCTTTAAAATTAAAACCAGACGTTGTTGTCATGGACTTGGTTATGCCAGAAATGGATGGTGTAGAAGCCACTCTTGAACTTCTAAAAGATTGGAAAGAAGCCAAAATTCTAGTTTTAACCAGTTATTTAGATAACGAAAAAATTTATCCTGTCATTGAAGCAGGTGCTAAAGGTTATATGTTGAAAACTTCCAGCGCAGCTGAAATTTTGAATGCCATTCAAAAAGTAGCTAAGGGAGATTTAGCGATTGAAACAGAAGTTGATAAGAAAATCAAGGATCATCATAATAATCCTGATTTGCATGAAGATTTAACAGCGCGTGAACGAGACATTTTGGCTTTACTTGCTAAGGGTTATGATAACCAAACGATTGCTGATGAGCTTTTCATTTCTTTGAAGACTGTCAAAACACATGTTTCTAATATCTTATCGAAATTACAAGTTGATGATCGGACCCAAGCCGTTGTCTATGCTTTTCAGCATCATTTAGTGCCACAGGACGAAAATTAG","5.00","-9.30","24054","MLMSKTKVILVDDHEMVRLGLKSFLNLQDNVEVIGEASNGRQGIDLALKLKPDVVVMDLVMPEMDGVEATLELLKDWKEAKILVLTSYLDNEKIYPVIEAGAKGYMLKTSSAAEILNAIQKVAKGDLAIETEVDKKIKDHHNNPDLHEDLTARERDILALLAKGYDNQTIADELFISLKTVKTHVSNILSKLQVDDRTQAVVYAFQHHLVPQDEN","456980","","two-component response regulator","Cytoplasm","Matches in gapped BLAST to two-component response regulator sequences. Residues 3-215 are 84% similar to gi15675498 from S.pyogenes. Residues 7-214 are 74% similar to gi15900310 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0322 (1e-96).","

InterPro
IPR000792
Domain

Bacterial regulatory protein, LuxR
PD000307	$\"[150-207]T$	HTH_LuxR
PR00038	$\"[150-164]T$ $\"[164-180]T$ $\"[180-192]T$	HTHLUXR
PF00196	$\"[147-204]T$	GerE
SM00421	$\"[147-204]T$	HTH_LUXR
PS00622	$\"[164-191]T$	HTH_LUXR_1
PS50043	$\"[143-208]T$	HTH_LUXR_2

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[7-123]T$	Response_reg
PF00072	$\"[6-120]T$	Response_reg
SM00448	$\"[6-119]T$	REC
PS50110	$\"[7-123]T$	RESPONSE_REGULATORY

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[4-134]T$	CheY_like

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[139-212]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[1-127]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[3-124]T$	PTHR23283
PTHR23283:SF47	$\"[3-124]T$	PTHR23283:SF47
SSF46894	$\"[144-210]T$	SSF46894

","BeTs to 4 clades of COG2197COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG2197 is -------CEBRh---------Number of proteins in this genome belonging to this COG is 4","***** IPB000792 (Bacterial regulatory protein, LuxR family) with a combined E-value of 8.5e-24. IPB000792 150-196***** IPB000673 (CheB methylesterase) with a combined E-value of 1.3e-17. IPB000673A 8-18 IPB000673B 25-78***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 1.5e-12. IPB001867A 53-66 IPB001867B 81-125 IPB001867C 148-179***** IPB001789 (Response regulator receiver domain) with a combined E-value of 5.3e-10. IPB001789A 8-14 IPB001789B 53-66 IPB001789C 101-110","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 16:39:27 2002","Wed Aug 23 16:03:12 2006","Wed Aug 23 16:03:12 2006","Wed Aug 23 16:03:12 2006","Mon Jan 7 16:52:47 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0441 is paralogously related (blast p-value < 1e-3) to SMu1782, SMu1406, SMu1748, SMu0237, SMu0601, SMu1379, SMu1048, SMu0841, SMu1032, and SMu0918, other predicted response regulators.","Fri Feb 8 16:41:34 2002","Wed Aug 23 16:03:12 2006","pdb1A04A Chain A, The Structure Of The NitrateNITRITE RESPON... 138 8e-034pdb1TMY Chey From Thermotoga Maritima (Apo-I) >gi2781153p... 90 2e-019pdb1SRRA Chain A, Crystal Structure Of A Phosphatase Resistan... 64 2e-011","SMU.487","","Residues 6 to 127 (E-value = 1.7e-31) place SMu0441 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 147 to 204 (E-value = 1.8e-24) place SMu0441 in the GerE family which is described as Bacterial regulatory proteins, luxR family (PF00196)","Wed Aug 23 16:03:12 2006","24378972","","Bhagwat SP, Nary J, Burne RA.Effects of mutating putative two-component systems on biofilm formation by Streptococcus mutans UA159.FEMS Microbiol Lett. 2001 Dec 18;205(2):225-30.PMID: 11750807"," ","Tue Nov 5 08:47:27 2002","Tue Nov 5 08:47:27 2002","1","","","SMU.487","525" "SMu0442","457027","458442","1416","ATGGATCTTAGAATAAAAAACAAAGCCAAAAAAATAAAAGCCGTCTTTTTTGATATTGATGATACCTTACGCATCAAAGATACGGGTTATATGCCTGATTCAATCAAAAAAGTCTTTGAAAGCTTACAAGAAAAGGATATTTTAACTGGTATTGCTTCAGGGAGGGCACCTTACGGTGTTGTTCCAGAAATTCGTCAATTAAATCCAGATTTTTTTGTCACCATTAATGGTTCCTATGTGATTAATCATAAAGGTGAAGAATTATCTAATGATCCAATTCCTAAAGATATTATTGAAAAATATGTTGTTTGGTGCCAAGAAATTGGTATTGAGTATGGTTTTGCTGGTAAAGACAAAGCTGTTGTTTCAAAACGAACAGAGTTGGTTGATAAGGCTCTAGTCCCTGTTTATGGTTTTTGTCCTGTTGAACCCGATTTTTATAAAAATCATGAGGTTTATCATATGTGGACCTTTGAGGATGTGGGTGACAGCTTACAACTTTCAGATGAATTGAAAGAAGATGTCCGTTTGGTACGTTGGCATGAAAATTCTTCAGATGTTATTAAGAATGGTATTTCCAAAGCGTCAGGACTTGCTCATGTTCTAAAAAAAGTCCATTTAAAACCAGAAAATGTTCTTTTCTTTGGTGATGGACCAAATGATATGGAAATATTTGATTATGTTGGTCTCAAAGTTGCCATGGGCAATGGTCATGGTGATTTAAAAGAGAAAGCTGATTTTATTACAAAAAATGTAGAAGAAGATGGCATTTTGTATGCCTTGGAGGAATTAGGTTTGGTAGAAAAAGAATTACAATTTCCACAATTAGATGTGACTAATGATGATGCCCCTATGGCTCTTATCAAAACGAATTATGGCGATTTAAAGGTGAAATTATTCCCTAAACAGGCCCCAAAAACAGTAGCCAATTTTGTTGCTTTAGCTAAGGATGGCTACTATGATGGTGTGATTTTCCACCGTGTTATTAAAGACTTCATGATTCAAGGTGGCGATCCAACTGGTACTGGTATGGGTGGTGAATCCATCTATGGTGAGCGTTTTGAAGATGAATTTTCAGAGGAACTTTACAATCTTCGAGGCGCTCTTTCTATGGCCAATGCAGGTCCAAATACCAATGGGAGTCAATTTTTCATTGTTCAAAATCAGAATCTTCCATATAGCGCTAAAGAATTAGAACGTGGCGGTTGGCCTAAGGAAATTGCAGCAGCCTATGCCGAAAATGGAGGAACACCGCATCTTGACCGCCGTCATAGCGTTTTTGGTCAACTAGTTGATCAAGCTTCTTATGAAGCTCTTGATAATATTGCTAATGTTGATACAGGAGTTGCTGATAAACCTATAGATGACATTGTGATTGAGAGCATCGAGGTGATTGATGATGAAAATAGGGGATAA","4.60","-25.63","52592","MDLRIKNKAKKIKAVFFDIDDTLRIKDTGYMPDSIKKVFESLQEKDILTGIASGRAPYGVVPEIRQLNPDFFVTINGSYVINHKGEELSNDPIPKDIIEKYVVWCQEIGIEYGFAGKDKAVVSKRTELVDKALVPVYGFCPVEPDFYKNHEVYHMWTFEDVGDSLQLSDELKEDVRLVRWHENSSDVIKNGISKASGLAHVLKKVHLKPENVLFFGDGPNDMEIFDYVGLKVAMGNGHGDLKEKADFITKNVEEDGILYALEELGLVEKELQFPQLDVTNDDAPMALIKTNYGDLKVKLFPKQAPKTVANFVALAKDGYYDGVIFHRVIKDFMIQGGDPTGTGMGGESIYGERFEDEFSEELYNLRGALSMANAGPNTNGSQFFIVQNQNLPYSAKELERGGWPKEIAAAYAENGGTPHLDRRHSVFGQLVDQASYEALDNIANVDTGVADKPIDDIVIESIEVIDDENRG","458439",""," hydrolase; possible peptidyl-prolyl cis-trans isomerase","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and to possible Cof family protein/peptidyl-prolyl cis-trans isomerases. Residues 1-453 are 61% similar to gi15903436 from S.pneumoniae and 61% similar to the S.pneumoniae sequenced by TIGR and postulated to be a Cof family protein/peptidyl-prolyl cis-trans isomerase,cyclophilin type (gi15901382).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0323 (1e-171).","

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[14-261]T$	Cof-subfamily

InterPro
IPR002130
Domain

Peptidyl-prolyl cis-trans isomerase, cyclophilin-type
PR00153	$\"[299-314]T$ $\"[325-337]T$ $\"[367-382]T$	CSAPPISMRASE
G3DSA:2.40.100.10	$\"[285-465]T$	PPIase_cyclophilin
PF00160	$\"[285-465]T$	Pro_isomerase
PS00170	$\"[320-337]T$	CSA_PPIASE_1
PS50072	$\"[290-464]T$	CSA_PPIASE_2
SSF50891	$\"[276-466]T$	CSA_PPIase

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[14-234]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[15-261]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[8-277]T$	G3DSA:3.40.50.1000
PTHR11071	$\"[286-390]T$ $\"[418-467]T$	PTHR11071
SSF56784	$\"[12-270]T$	SSF56784

","BeTs to 8 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","***** IPB002130 (Cyclophilin-type peptidyl-prolyl cis-trans isomerase) with a combined E-value of 4.6e-43. IPB002130A 293-314 IPB002130B 320-358 IPB002130C 369-406 IPB002130B 319-357***** IPB000150 (Cof protein) with a combined E-value of 3.8e-17. IPB000150A 11-25 IPB000150B 46-55 IPB000150C 213-245","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 16:57:19 2002","Thu Jul 20 11:26:59 2006","Thu Jul 20 11:26:59 2006","Tue Oct 8 09:33:53 2002","Fri Feb 8 16:56:51 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0442 is paralogously related (blast p-value < 1e-3) to SMu1484, a predicted peptidyl-prolyl cis-trans isomerase, and to SMu1666, SMu0655, SMu0674, SMu1012, SMu0675, SMu0461, SMu0388, and SMu0367, mostly conserved hypotheticals.","Fri Feb 8 16:59:53 2002","Thu Jul 20 11:26:59 2006","pdb2RMCA Chain A, Cyclophilin C Complexed With Cyclosporin A ... 87 6e-018pdb1CYNA Chain A, Cyclophilin B Complexed With [d-(Cholinyles... 82 2e-016pdb1DYWA Chain A, Biochemical And Structural Characterization... 78 2e-015","SMU.488","","Residues 12 to 238 (E-value = 1.7e-05) place SMu0442 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)Residues 285 to 465 (E-value = 5.4e-53) place SMu0442 in the Pro_isomerase family which is described as Cyclophilin type peptidyl-prolyl cis-trans isomerase (PF00160)","Thu Jul 20 11:26:59 2006","24378973","","","","","","1","","","SMU.488","42" "SMu0443","458420","458812","393","TTGATGATGAAAATAGGGGATAAGCTAAAAGGAAAAATCACAGGAATTAAGCCTTACGGTGCCTTTGTCCAATTAGAAAATGGCTCAATTGGTCTCATCCATATCTCAGAAATCAAAACGGGTTATATTGATAATATTTATCAGACATTATCGGTTGGTCAAGAAGTTCTTGTTCAAGTCGTTGATTATGATGAATATAGTCAAAAAGCCAGTCTTTCTTTGCGAACTTTGGAAGAAGAAAAACATCATTACCAACATCGCCATCGTTTTTCTAATAATCGTTTAAATATTGGTTTTAAACCTTTAGAAGAACATTTACCAATCTGGGTTGAAGAAAATCTTGATTATTTGAAAAAGGATCAAGATGAGAGTGATAATCAAGCTAAGGATTAA","5.90","-3.56","15071","MMMKIGDKLKGKITGIKPYGAFVQLENGSIGLIHISEIKTGYIDNIYQTLSVGQEVLVQVVDYDEYSQKASLSLRTLEEEKHHYQHRHRFSNNRLNIGFKPLEEHLPIWVEENLDYLKKDQDESDNQAKD","458809","","polyribonucleotide nucleotidyltransferase (general stress protein 13)","Cytoplasm","Matches in gapped BLAST to polyribonucleotide nucleotidyltransferase sequences. Residues 3-124 are 69% similar to gi15675497 from S.pyogenes. Residues 3-119 are 65% similar to gi15901381 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0324 (1e-51).","

InterPro
IPR003029
Domain

RNA binding S1
PF00575	$\"[2-75]T$	S1
SM00316	$\"[4-75]T$	S1
PS50126	$\"[6-75]T$	S1

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[3-77]T$	no description

noIPR
unintegrated

unintegrated
PTHR10724	$\"[3-127]T$	TEX PROTEIN-RELATEDTRANSCRIPTION ACCESSORY PROTEIN (S1 RNA BINDING DOMAIN)

","BeTs to 8 clades of COG0539COG name: Ribosomal protein S1Functional Class: JThe phylogenetic pattern of COG0539 is ----YqvCebrhuj--olinxNumber of proteins in this genome belonging to this COG is 2","***** PR00681 (Ribosomal protein S1 signature) with a combined E-value of 4.2e-11. PR00681H 19-38 PR00681I 58-76 PR00681G 27-48***** IPB003029 (S1 RNA binding domain) with a combined E-value of 1.1e-06. IPB003029A 11-22 IPB003029B 53-64","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 8 17:06:09 2002","Fri Feb 8 17:06:09 2002","Mon Jul 3 17:19:31 2006","Mon Jul 3 17:19:31 2006","Fri Feb 8 17:01:10 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0443 is paralogously related (blast p-value < 1e-3) to SMu1097, SMu0682, and SMu0138.","Fri Feb 8 17:06:09 2002","","No significant hits to the NCBI PDB database.","SMU.489","","Residues 2 to 75 (E-value = 3.5e-20) place SMu0443 in the S1 family which is described as S1 RNA binding domain (PF00575)","Fri Feb 8 17:01:10 2002","24378974","","","","","","1","","","SMU.489","758" "SMu0444","459667","458891","777","ATGACTAGCGAAAAAGGAATTATCTTTAATATCCAGCATTTTTCCATCCATGATGGCCCTGGTATTCGCACAACTGTGTTTTTAAAGGGTTGTCCTCTACGCTGTCCTTGGTGTTCTAATCCTGAATCTCAAAAATATAAACCCGAACAAATGCTGGATGCCGAAACAAAATTACCAATGATTATAGGGGAAGAAAAAACAGTGGAGGACATCATATCAGAAGTTAAAAAGGATATTGATTTCTATGAGGAATCCGGAGGTGGTCTCACGCTGTCTGGTGGTGAAATTTTTGCCCAATTTGAATTTGCCAAGGCCATTCTTAAATGTGCCAAAGAAGAAGGACTCCATACAGCCATTGAAACAACAGCTTTTGCCGAGCATGAAAAATTTACCGATTTGATTCAATATGTTGATTTTATTTATACTGATTTGAAACATTACAATACTATTCGACATCGCAAAGTAACTGGTGTCAATAATAATTTTATCATCCAAAACATTCATTATGCCTTTACGCACAAAAAAACGATCGTTTTGAGAATTCCTGTCATTCCTGATTTTAATAATTCCTTAGATGATGCTGAACACTTTGCAAAACTTTTTAATGATATTCAAGTAGATAAAGTCCAACTGCTTCCTTTTCATCAATTTGGAGAAAATAAGTACAAATTCCTCAATCGGAAATATGAAATGTCCGGCTACACAGCTCTTCATCCGGAAGACCTTTATGATTACCAATCTGTTTTTCTAGAACATGGCATTGACTGTTATTTTTAA","5.80","-8.33","29864","MTSEKGIIFNIQHFSIHDGPGIRTTVFLKGCPLRCPWCSNPESQKYKPEQMLDAETKLPMIIGEEKTVEDIISEVKKDIDFYEESGGGLTLSGGEIFAQFEFAKAILKCAKEEGLHTAIETTAFAEHEKFTDLIQYVDFIYTDLKHYNTIRHRKVTGVNNNFIIQNIHYAFTHKKTIVLRIPVIPDFNNSLDDAEHFAKLFNDIQVDKVQLLPFHQFGENKYKFLNRKYEMSGYTALHPEDLYDYQSVFLEHGIDCYF","458894","For other 'pfl' genes see SMu0363 (pfl); SMu1542 (pflA) and SMu0446 (pfl-2), (pfl).","pyruvate formate-lyase activating enzyme","Cytoplasm","Matches in gapped BLAST to pyruvate formate-lyase-activating enzymes. Residues 1-258 are 73% similar to gi|15900180 from S.pneumoniae. Residues 1-231 are 31% similar to gi|11499045 from A.fulgidus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0325 (1e-104).","

InterPro
IPR001989
Domain

Radical-activating enzyme
PS01087	$\"[19-40]T$	RADICAL_ACTIVATING

InterPro
IPR002012
Family

Gonadotropin-releasing hormone
PS00473	$\"[12-21]?$	GNRH

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[25-198]T$	Radical_SAM

InterPro
IPR012839
Family

Glycyl-radical enzyme activating
TIGR02494	$\"[8-253]T$	PFLE_PFLC

noIPR
unintegrated

unintegrated
SSF102114	$\"[20-222]T$	SSF102114

","BeTs to 8 clades of COG1180COG name: Pyruvate-formate lyase-activating enzymeFunctional Class: OThe phylogenetic pattern of COG1180 is AMTk-qV-E-rH---------Number of proteins in this genome belonging to this COG is 2","***** IPB001989 (Radical activating enzymes) with a combined E-value of 3.8e-20. IPB001989A 17-44 IPB001989B 88-99","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Nov 5 08:48:22 2002","Fri Feb 8 17:14:02 2002","Sun Oct 27 18:31:22 2002","Wed Apr 10 15:50:38 2002","Fri Feb 8 17:14:02 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0444 is paralogously related (blast p-value < 1e-3) to SMu1542, also a predicted PflC protein, and to SMu1879, a predicted ribonucleoside-triphosphate reductase activating protein.","Fri Feb 8 17:23:51 2002","","No significant hits to the NCBI PDB database.","SMU.490c","","Residues 25 to 198 (E-value = 3.3e-17) place SMu0444 in the Radical_SAM family which is described as Radical SAM superfamily (PF04055)","Fri Feb 8 17:14:02 2002","","","","Yamamoto Y, Sato Y, Takahashi-Abbe S, Takahashi N, Kizaki H.Characterization of the Streptococcus mutans pyruvate formate-lyase (PFL)-activating enzyme gene by complementaryreconstitution of the In vitro PFL-reactivating system.Infect Immun. 2000 Aug;68(8):4773-7.PMID: 10899886","Tue Nov 5 08:48:22 2002","Fri Feb 8 17:21:48 2002","1","","","SMU.490c","" "SMu0445","459798","460544","747","ATGAAACGTTTAGATGAGATTATTAACTTAGTTTCTCAGGAGAAAAAAATAGATGTTAATACCTTATCTGAAAAATTAGGCGTATCGAAAGTAACTATTCGTAAAGATTTAGATAAATTGGAAAGCAAAGGATTGCTGCATCGTGAGCACGGTTATGCAGTATTAAATAGTGGTGATGACTTAAATGTCAGGCTTTCTTACAACTATAATATCAAAAAGCGTATTGCTGCAAAGGCAGTTGAATTGGTACGTGACAATGAAACCATTATGATTGAATCAGGTTCAACCTGTGCTTTGTTAGCGGAAGCTATTTGTCAAAGTAGACGCAATGTCAAAATTATTACCAATTCTTGTTTTATTGCAACTTACATTCGAAAGTATGATTCTTGTCAAGTGATTTTACTTGGTGGTAATTATCAACCTAATTCTGAAGTAACTGTTGGCCCCTTGCTAAAAGAAATGCTTAAGCTGTTTCATGTTGAAAAGTTGTTTGTAGGAACAGATGGCTTTGACGATGAGCTAGGGTTTATGGGAAAAGACATGATGCGATGTGAAGTTGTTCAATATATGGCTGAATCTGCTGATGAATTGGTTGTCTTAACAGATTCAAGTAAATTTGCTAAGCGTAGTTTGGTCAATCAATTTACTTTGAGTCAAGTTTCGCAAGTCATAACAGATTCTGCCATTTCAGAAGCAAGACGTGAGCATTTAATAGCTAATCATATTAATCTAAAATTGGTCAATTAA","7.40","0.98","27904","MKRLDEIINLVSQEKKIDVNTLSEKLGVSKVTIRKDLDKLESKGLLHREHGYAVLNSGDDLNVRLSYNYNIKKRIAAKAVELVRDNETIMIESGSTCALLAEAICQSRRNVKIITNSCFIATYIRKYDSCQVILLGGNYQPNSEVTVGPLLKEMLKLFHVEKLFVGTDGFDDELGFMGKDMMRCEVVQYMAESADELVVLTDSSKFAKRSLVNQFTLSQVSQVITDSAISEARREHLIANHINLKLVN","460541","","transcriptional regulator, DeoR family","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Residues 1-248 are 73% similar to gi15675824 from S.pyogenes and 67% similar to gi15902271 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0326 (1e-92).","

InterPro
IPR001034
Domain

Bacterial regulatory protein, DeoR N-terminal
PR00037	$\"[21-35]T$ $\"[35-53]T$	HTHLACR
PF08220	$\"[3-59]T$	HTH_DeoR
SM00420	$\"[3-55]T$	HTH_DEOR
PS00894	$\"[3-37]T$	HTH_DEOR_1
PS51000	$\"[1-55]T$	HTH_DEOR_2

InterPro
IPR014036
Domain

Bacterial regulatory protein, DeoR
PF00455	$\"[69-226]T$	DeoR

noIPR
unintegrated

unintegrated
SSF100950	$\"[66-230]T$	SSF100950
SSF46785	$\"[2-56]T$	SSF46785

InterPro
IPR001150
Domain

Formate C-acetyltransferase glycine radical
PF01228	$\"[695-800]T$	Gly_radical
PS00850	$\"[789-797]?$	GLY_RADICAL_1
PS51149	$\"[697-818]T$	GLY_RADICAL_2

InterPro
IPR004184
Domain

Pyruvate formate-lyase, PFL
PF02901	$\"[30-679]T$	PFL

InterPro
IPR010098
Family

Pyruvate formate-lyase
TIGR01774	$\"[18-818]T$	PFL2-3

noIPR
unintegrated

unintegrated
G3DSA:3.20.70.20	$\"[83-816]T$	G3DSA:3.20.70.20
SSF51998	$\"[18-818]T$	SSF51998

","BeTs to 3 clades of COG1882COG name: Pyruvate-formate lyaseFunctional Class: CThe phylogenetic pattern of COG1882 is a-t-----E--H---------Number of proteins in this genome belonging to this COG is 2","***** IPB001150 (Pyruvate formate-lyase, glycine radical) with a combined E-value of 1.2e-24. IPB001150B 768-817","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 14:38:02 2002","Thu Oct 10 14:38:02 2002","Tue Feb 12 12:37:46 2002","Wed Apr 10 15:41:28 2002","Fri Jan 25 15:43:25 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0446 is paralogously related (blast p-value < 1e-3) to SMu0363, another predicted pfl protein.","Fri Jan 25 15:46:25 2002","Fri Jan 25 15:43:25 2002","pdb|3PFL|A Chain A, Crystal Structure Of Pfl From E.Coli In Com... 189 2e-048pdb|1CM5|A Chain A, Crystal Structure Of C418a,C419a Mutant Of ... 186 8e-048pdb|1QHM|A Chain A, Escherichia Coli Pyruvate Formate Lyase Lar... 99 2e-021","SMU.493","","Residues 30 to 679 (E-value = 1.2e-166) place SMu0446 in the PFL family which is described as Pyruvate formate lyase (PF02901)Residues 695 to 800 (E-value = 9e-26) place SMu0446 in the Gly_radical family which is described as Glycine radical (PF01228)","Fri Jan 25 15:43:25 2002","24378977","","Yamamoto,Y., Sato,Y., Takahashi-Abbe,S., Abbe,K., Yamada,T. andKizaki,H.Cloning and sequence analysis of the pfl gene encoding pyruvateformate-lyase from Streptococcus mutansInfect. Immun. 64 (2), 385-391 (1996)PubMed: 96145053Asanuma,N., Iwamoto,M. and Hino,T.Structure and transcriptional regulation of the gene encodingpyruvate formate-lyase of a ruminal bacterium, Streptococcus bovisMicrobiology 145 (Pt 1), 151-157 (1999)PubMed: 99140147Iwami Y, Takahashi-Abbe S, Takahashi N, Abbe K, Yamada T.Rate-limiting steps of glucose and sorbitol metabolism in Streptococcus mutans cells exposed to air.Oral Microbiol Immunol. 2000 Oct;15(5):325-8.PMID: 11154425","Melchiorsen CR, Jensen NB, Christensen B, Vaever Jokumsen K, Villadsen J. Dynamics of pyruvate metabolism in Lactococcus lactis. Biotechnol Bioeng. 2001 Aug 20;74(4):271-9. PMID: 11410851","Fri Jan 25 15:48:20 2002","Fri Jan 25 15:49:30 2002","1","","","SMU.493","" "SMu0447","463268","463936","669","ATGGAATTTATGCTTGATACACTCAACTTAGCAGACATTGAAAAATGGGCAGCAATCCTACCATTAGCTGGGGTAACTTCCAACCCATCAATTGCTAAAAAAGAAGGAAAAATTGATTTTTTTGAGCAAGTGAAAAGGGTTCGTGCCATTATTGGTGAAGAACCAAGTATTCATGCACAAGTGGTTGCGGCAGATGTGGAAGGGATTATTAAAGATGCCCACAAACTTCAAGATGAACTTGGCGGCAATCTCTATGTTAAAGTGCCTGTCTCTCCAACTGGCTTAACAGCGATGAAGCAACTAAAAGAAGAAGGATTTCAAATCACTGCTACGGCTATTTATACAGTTTTTCAAGGCCTTTTAGCCATTGAAGCTGGCGCAGACTATCTTGCCCCTTACTATAATCGTATGGAAAATCTTAATATAGACCCAATTGAGGTGATTGGTCAACTTGCTCAGGCTATTGAGTGTCAACAAGCTTCTGCAAAAATCTTGGCAGCAAGCTTTAAAAATGTTACTCAGGTTGCCAAGGCTTTAGCAGCGGGTGCTAAAGCCGTTACTGCTGGTGCAGATATTTTTGCTGCTGGTTTTGCCAATCCATCCATTCAAAAAGCTGTTGATGATTTTGCAGCAGATTGGGAAAGCACACAAGGACGTCCTTATATTTAA","4.70","-7.56","23766","MEFMLDTLNLADIEKWAAILPLAGVTSNPSIAKKEGKIDFFEQVKRVRAIIGEEPSIHAQVVAADVEGIIKDAHKLQDELGGNLYVKVPVSPTGLTAMKQLKEEGFQITATAIYTVFQGLLAIEAGADYLAPYYNRMENLNIDPIEVIGQLAQAIECQQASAKILAASFKNVTQVAKALAAGAKAVTAGADIFAAGFANPSIQKAVDDFAADWESTQGRPYI","463933","","transaldolase family protein","Cytoplasm, Periplasm","Matches in gapped BLAST to transaldolase-like proteins. Residues 1-222 are 64% similar to gi15675818 from S.pyogenes. Residues 1-213 are 64% similar to gi15900187 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0332 (1e-70).","

InterPro
IPR001585
Family

Transaldolase
PTHR10683	$\"[1-219]T$	Transaldolase
PF00923	$\"[2-220]T$	Transaldolase

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-222]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR10683:SF1	$\"[1-219]T$	PTHR10683:SF1
SSF51569	$\"[1-222]T$	SSF51569

","BeTs to 7 clades of COG0176COG name: TransaldolaseFunctional Class: GThe phylogenetic pattern of COG0176 is -m--YqvcEbrhuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB001585 (Transaldolase) with a combined E-value of 3.3e-10. IPB001585A 17-32 IPB001585C 84-97 IPB001585D 104-139","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 12 12:42:55 2002","Thu Sep 28 10:22:01 2006","Thu Sep 28 10:22:01 2006","Tue May 7 11:05:27 2002","Tue Feb 12 12:40:06 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0447 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 12:42:55 2002","","No significant hits to the NCBI PDB database.","SMU.494","","Residues 2 to 220 (E-value = 1.9e-33) place SMu0447 in the Transaldolase family which is described as Transaldolase (PF00923)","Tue Feb 12 12:40:06 2002","24378978","","","","","","1","","","SMU.494","" "SMu0448","463971","465065","1095","ATGATGAAAATTTTTGCCAGCCCATCACGTTATATTCAGGGTGAAAAAGCTTTATTTGAAAATGCAAAAGCTATTATTAATTTGGGTTCTCATCCTATCCTTTTAACAGACAATGTCGTTTATGATATTGTTGGTAAACGTTTCGAAACTTATCTTAACCAAGAAGGATTGATAGTAGATCGTATAGCCTTTAATGGTGAAGCTTCAATAAACGAAATTGATCGCGTTGTTGCTATAGCTAAAGAAAAGGGAAATGATTTAATTATTGGTCTTGGTGGGGGAAAGACGATTGACAGTGCTAAAGCCATTGCTGATTTATTAGAGATACCTGTTATTATTGCTCCTACAGTTGCCTCGACAGATGCTCCAACATCAGCCTTGTCCGTCATTTATACTGACCAAGGTGCTTTTGAAAAATACATTTTCTATTCCAAAAATCCAGATCTTGTTTTAGTAGATACTGAAGTCATCAGTAAATCTCCAGTTATTCTACTGGCTTCGGGAATTGCAGATGGACTTGCTACTTGGGTAGAAGCAAGAGCTGTGCTTCAAAAAAATGGGCAAACAATGACTGGTGCAGGGCAAACTTTAGCTAGCCTTGCTATTGCCCAAGCCTGTGAGCGTACTTTATTTGCAGATGGTCTACAAGCGCTGGCAGCTTGTGAAGCAAAAGTAGTGACAAGAGCACTTGAAAATGTTATAGAGGCTAATACCTTATTAAGTGGTTTAGGGTTTGAAAGTGCAGGTTTGGCCGCAGCTCACGCTATTCATAACGGTTTTACAGCCTTAACGGGAGATATTCATCATCTGACACATGGTCAAAAAGTTACTTATGGAACCTTAACGCAACTCTTTCTTGAAAATCGTCCAAAAGAAGAAATTGATAAGTATATTCATTTTTATAGAGCAATTGGCATGCCAACGACTTTAGAAGAAATGCACTTGGGAGATGCTGACTATTCTGAACTTCTAAAGATTGGCCAACAAGCTACAATTGAAGGCGAAACGATTCATCAAATGCCATTTGAAATTAAGGCAGGTGATGTTGCCAATGCACTCTTAGCAGTAGATCAGTACACTAGATCATTAAAATAA","4.90","-12.90","39130","MMKIFASPSRYIQGEKALFENAKAIINLGSHPILLTDNVVYDIVGKRFETYLNQEGLIVDRIAFNGEASINEIDRVVAIAKEKGNDLIIGLGGGKTIDSAKAIADLLEIPVIIAPTVASTDAPTSALSVIYTDQGAFEKYIFYSKNPDLVLVDTEVISKSPVILLASGIADGLATWVEARAVLQKNGQTMTGAGQTLASLAIAQACERTLFADGLQALAACEAKVVTRALENVIEANTLLSGLGFESAGLAAAHAIHNGFTALTGDIHHLTHGQKVTYGTLTQLFLENRPKEEIDKYIHFYRAIGMPTTLEEMHLGDADYSELLKIGQQATIEGETIHQMPFEIKAGDVANALLAVDQYTRSLK","465062","For other 'gld' genes see SMu1196 (gldA-2).","glycerol dehydrogenase","Cytoplasm","Matches in gapped BLAST to glycerol dehydrogenase sequences. Residues 2-362 are 75% similar to gi|15902278 from S.pneumoniae and 77% similar to gi|15675817 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0333 (1e-160).","

InterPro
IPR001670
Domain

Iron-containing alcohol dehydrogenase
PF00465	$\"[8-349]T$	Fe-ADH

noIPR
unintegrated

unintegrated
G3DSA:1.20.1090.10	$\"[160-359]T$	G3DSA:1.20.1090.10
G3DSA:3.40.50.1970	$\"[3-159]T$	G3DSA:3.40.50.1970
PTHR11496	$\"[125-344]T$	PTHR11496
SSF56796	$\"[1-364]T$	SSF56796

","BeTs to 8 clades of COG0371COG name: Glycerol dehydrogenaseFunctional Class: CThe phylogenetic pattern of COG0371 is amtk--VcEb-----------Number of proteins in this genome belonging to this COG is 2","***** IPB001670 (Iron-containing alcohol dehydrogenase) with a combined E-value of 5.7e-20. IPB001670A 86-98 IPB001670C 147-180 IPB001670D 254-269","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 14:42:05 2002","Thu Oct 10 10:57:15 2002","Tue Feb 12 12:47:29 2002","Wed Apr 10 16:48:06 2002","Tue Feb 12 12:44:24 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0448 is paralogously related (blast p-value < 1e-3) to SMu1196, also a predicted glycerol dehydrogenase.","Tue Feb 12 12:48:26 2002","","No significant hits to the NCBI PDB database.","SMU.495","","Residues 8 to 349 (E-value = 3.9e-74) place SMu0448 in the Fe-ADH family which is described as Iron-containing alcohol dehydrogenase (PF00465)","Tue Feb 12 12:44:24 2002","24378979","","","Truniger V, Boos W.Mapping and cloning of gldA, the structural gene of the Escherichia coli glycerol dehydrogenase.J Bacteriol. 1994 Mar;176(6):1796-800.PMID: 8132480 ","","Tue Feb 12 12:50:59 2002","1","","","SMU.495","" "SMu0449","466325","465399","927","ATGGCAAAAATTTATAACAACATTACTGAATTAATTGGCAATACACCTATTGTAAAACTCAACAATGTTGTTCCTGAAGATGCAGCTGATGTTTATGTTAAACTTGAAGCTTTCAATCCTGGTTCTTCCGTTAAAGATCGGATTGCTTTAAGCATGATTGAAGATGCTGAAAAACGTGGTCTCATCAAACCTGGAGATACCATTGTCGAACCGACAAGTGGTAATACAGGTATTGGACTTTCATGGGTCGGCGCTGCCAAAGGTTACAATGTCATTATTACAATGCCTGAAACAATGAGCGTTGAACGCCGCAAAATTATACAAGCTTACGGTGCCAAACTCGTATTGACACCAGGAAGTGCTGGTACTAAGGGTGCCATTGACAAAGCTCACGAGATTGCCAAAGAAGTTGGTGGTTGGGTGCCTCTGCAATTTGACAATCCAGCTAATCCAAAAATTCACGAATTGACAACAGGTCCTGAGATTCTGGAAGCATTTGGTTCACATGGACTTGATGCTGTCGTTGCTGGTATTGGTACTGGTGGTACGATTACTGGGATTTCACGTGCCCTTAAAAAAGACAATCCTGACATTAAAATCTATGGATTGGAAGCTGATGAATCTGCTGTTTTGTCAGGTGACAAACCGGGGCCCCATAAAATCCAAGGTATCTCAACAGGCTTTATCCCAGCTGCATTAGATACTCATTCTTATGATGAAGTTATCCGTGTTAAATCTGATGATGCTTTGGCTACTGGTCGCTACTTCGGCGGTAAGGAAGGATTCCTACTTGGCATCTCCGCTTCTGCTGCTGTCTGGGCCGCACTTGAAGTCGCTAAAAAACTCGGTAAGGGTAAAAAAGTCTTGGCTATTGCACCTGATAATGGTGAGCGTTATCTTTCAACCGCACTTTATGAATTTAACTAA","6.10","-2.78","32423","MAKIYNNITELIGNTPIVKLNNVVPEDAADVYVKLEAFNPGSSVKDRIALSMIEDAEKRGLIKPGDTIVEPTSGNTGIGLSWVGAAKGYNVIITMPETMSVERRKIIQAYGAKLVLTPGSAGTKGAIDKAHEIAKEVGGWVPLQFDNPANPKIHELTTGPEILEAFGSHGLDAVVAGIGTGGTITGISRALKKDNPDIKIYGLEADESAVLSGDKPGPHKIQGISTGFIPAALDTHSYDEVIRVKSDDALATGRYFGGKEGFLLGISASAAVWAALEVAKKLGKGKKVLAIAPDNGERYLSTALYEFN","465402","For other 'cys' genes see SMu0141 (cysS) and SMu1074 (cysD).","cysteine synthetase A","Cytoplasm","Matches in gapped BLAST to O-acetylserine lyases and to cysK proteins. Residues 4-308 are 71% similar to gi6567187 from S.suis. Residues 4-306 are 69% similar to gi15902017 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0334 (1e-116).","

InterPro
IPR001216
Binding_site

Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site
PS00901	$\"[34-52]T$	CYS_SYNTHASE

InterPro
IPR001926
Domain

Pyridoxal-5'-phosphate-dependent enzyme, beta subunit
PF00291	$\"[8-295]T$	PALP

InterPro
IPR005856
Family

Cysteine synthase K/M
TIGR01136	$\"[8-305]T$	cysKM

InterPro
IPR005859
Family

Cysteine synthase A
TIGR01139	$\"[8-305]T$	cysK

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1100	$\"[118-303]T$	G3DSA:3.40.50.1100
PTHR10314	$\"[25-306]T$	PTHR10314
PTHR10314:SF8	$\"[25-306]T$	PTHR10314:SF8
SSF53686	$\"[3-305]T$	SSF53686

","BeTs to 8 clades of COG0031COG name: Cysteine synthase/cystathionine beta-synthaseFunctional Class: EThe phylogenetic pattern of COG0031 is ----YqvCEBRhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001216 (Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site) with a combined E-value of 1.6e-131. IPB001216A 12-21 IPB001216B 31-75 IPB001216C 80-129 IPB001216D 140-180 IPB001216E 216-270 IPB001216F 273-302***** IPB001926 (Pyridoxal-5'-phosphate-dependent enzymes, beta family) with a combined E-value of 1.8e-15. IPB001926A 68-95 IPB001926B 147-155***** IPB001721 (C-terminal domain of threonine dehydratase) with a combined E-value of 2.3e-06. IPB001721C 174-209","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 17:22:15 2006","Tue Feb 12 12:53:54 2002","Wed Sep 6 17:22:15 2006","Mon Apr 8 08:26:42 2002","Wed Sep 6 17:22:15 2006","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0449 is paralogously related (blast p-value < 1e-3) to SMu0212, a predicted threonine dehydratase, and to SMu0488, a predicted tryptophan synthetase beta subunit.","Tue Feb 12 12:58:29 2002","Wed Sep 6 17:22:15 2006","pdb1FCJA Chain A, Crystal Structure Of Oass Complexed With Ch... 233 3e-062pdb1D6SA Chain A, Crystal Structure Of The K41a Mutant Of O-A... 230 1e-061","SMU.496c","","Residues 8 to 295 (E-value = 5.8e-116) place SMu0449 in the PALP family which is described as Pyridoxal-phosphate dependent enzyme (PF00291)","Tue Feb 12 12:53:54 2002","","","","van der Ploeg JR, Barone M, Leisinger T.Functional analysis of the Bacillus subtilis cysK and cysJI genes.FEMS Microbiol Lett. 2001 Jul 10;201(1):29-35.PMID: 11445163Osaki M, Takamatsu D, Tsuji N, Sekizaki T.Cloning and characterization of the gene encoding O-acetylserine lyase from Streptococcus suis.Curr Microbiol. 2000 Jan;40(1):67-71.PMID: 10568807","","Tue Feb 12 13:02:27 2002","1","","","SMU.496c","261" "SMu0450","467045","466416","630","ATGAACTATCGAACAATCGCCAAAAACGGCAGCACTGAAGAAACTATTAAAAAATCACGATTTATTTGTCAGGCAAAAAGAATCACTAATGAAGCAGAAGGACGTGATTTTATTACTCAAATCAAAAAAGAGCATTACAAGGCACGACATTCATGCTCAGCTATGATTATTGGCGAAAACAGCGATATCAAACGATCCAGTGACGATGGTGAGCCCAGTGGAACTGCAGGCATCCCTATGTTAAGTGTCCTCGAAAAAAAGCAATTGACAAACCTTGTCCTTGTTGTAACACGTTATTTTGGTGGCATCAAGTTAGGAACAGGCGGACTGATCCGAGCTTATTCGGGTGGAGCTGCTAATACGCTCAAAGCTTTAGGAATCGTTGAAGTCAAAAAGCAGACAGGTTTGCGGTTGGAATTAACCTATCCACAATATCAGACCTTTGCTAATTTCTTGAAGGAACATCAACTGCAAGAATATGATACCGATTTTTCAGTGACTGTTAACACTACTATTTATGTGGATAAGAAAGATATTGAGTTCACCCTTGACCAACTTACTGAGTTTTATCAAGGAAAACTTAAAAGCCATGTTGCTGGTAATCAAATTATTGAAGTTCCCGTGATATGA","9.50","4.87","23375","MNYRTIAKNGSTEETIKKSRFICQAKRITNEAEGRDFITQIKKEHYKARHSCSAMIIGENSDIKRSSDDGEPSGTAGIPMLSVLEKKQLTNLVLVVTRYFGGIKLGTGGLIRAYSGGAANTLKALGIVEVKKQTGLRLELTYPQYQTFANFLKEHQLQEYDTDFSVTVNTTIYVDKKDIEFTLDQLTEFYQGKLKSHVAGNQIIEVPVI","466419","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-208 are 60% similar to gi|15904055 from S.pneumoniae. Residues 2-207 are 58% similar to gi|15675495 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0335 (2e-82).","

InterPro
IPR001498
Domain

Protein of unknown function UPF0029, N-terminal
PTHR16301	$\"[55-150]T$	UPF0029
PF01205	$\"[16-123]T$	UPF0029
PS00910	$\"[77-106]T$	UPF0029

InterPro
IPR009022
Domain

Elongation factor G, III and V
SSF54980	$\"[132-202]T$	EFG_III_V

InterPro
IPR015796
Family

Protein of unknown function UPF0029
TIGR00257	$\"[1-201]T$	UPF0029

noIPR
unintegrated

unintegrated
G3DSA:3.30.230.30	$\"[2-131]T$	G3DSA:3.30.230.30
SSF54211	$\"[1-131]T$	SSF54211

","BeTs to 6 clades of COG1739COG name: Uncharacterized ACR, YigZ/UPF0029 familyFunctional Class:� SThe phylogenetic pattern of COG1739 is ----Y-v-eb-huj--o----Number of proteins in this genome belonging to this COG is 1","***** IPB001498 (Uncharacterized protein family UPF0029) with a combined E-value of 2e-30. IPB001498A 17-37 IPB001498B 76-118","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 12 13:09:07 2002","Tue Feb 12 13:09:07 2002","Tue Feb 12 13:09:07 2002","Tue Feb 12 13:09:07 2002","Tue Feb 12 13:09:07 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0450 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 13:09:07 2002","","No significant hits to the NCBI PDB database.","SMU.497c","","Residues 16 to 123 (E-value = 1.6e-53) place SMu0450 in the UPF0029 family which is described as Uncharacterized protein family UPF0029 (PF01205)","Tue Feb 12 13:09:07 2002","24378981","","","","","","1","","","SMU.497c","638" "SMu0451","467118","468419","1302","ATGGAGAATTTAGAGAATTATTATGGCCGCCTCTTGACCGAGAATCAAATGAACAGTGATTTGAAAAAGCAAGCTAAAATCTTGCCAGCTATGATAAAAAAACCGCATTACTTTATCTGCAATCGTTGCGGCAGTCAGAACAATCTTGGTAATGCTTTGCCGGATGGATCTATCTACTGTCGAGCTTGTCTTGTCTTTGGACGTCTTACTAACAGGGACAGTCTTTATTATTTTGAGCAAAAGCCTTTTCCAAAGGGTCAGGTCTTAAGGTGGCAAGGGCAATTAACCCCTTTTCAGCAGGAAGTTTCCCGTGGTTTAAAAAAGAGTGTTTGCCATAAGGAAAATATGCTTATTCATGCTGTAACAGGTGCAGGCAAAACGGAGATGATTTATGAAACTCTGGCCAGCATTCTCAATCAAGGGGGTGCGGTTGCACTTGCTAGTCCTCGCATTGATGTCTGCATAGAACTGTATAAACGTTTAAGTCGTGACTTTTCTTGTCCTATCAGTCTTTTGTATGGAGAGTCAGAAGCTTATGAACGCAGTCCATTAGTGATTGCAACCACGCATCAACTTTTGAAATTTTACCGAGCTTTTGATTTGTTAATTATTGATGAAGTAGATGCCTTTCCTTTTGTTGACAATAAGATGCTCTATTATGCTGTAGATCATTGTCTGAAATCAGATGGTGTCAAAGTATTTTTGACTGCAACTTCGACTGACCAATTAGACAAACAGGTTAAGCAAGGGAAGCTAAAAAAACTGCATTTAGCCAGACGATTTCATGCCAATCCCTTAGTTGTTCCCAAGCCAATTTGGTTGAATTTATCTCTTGAAAGATTACAAAGAGGTAAATTACCGCGCTCTTTTTTACAGCAGATAAGAATTCAAAGGCAGACTCAATTCCCTCTTTTGATCTTTTTTCCGAATATTGAAGATGGTTTAACCTTTGCTAAATCACTGCAAACCTATCTTCCAAATGAGAAAATTGATTTTGTTTCCAGCTTGACAACAGATCGTTTAGAAAAAGTCGAAAATTTTAGAAAAGGAAACACACAAATTTTGGTTTCAACAACGATTTTAGAGAGGGGAGTCACTTTTCCTTGTGTAGATGTTTTTGTCATGATGAGCAACCATTATCTGTTCACCAAAAGTTCTCTGGTACAGATTGCTGGTCGTGTGGGACGCTCTGCCGATAGACCAGATGGAAAATTACTTTTCTTTCATAATGGAATGAACAGAGCCATGAAAAAGGCCATTATGGAAATCAAGACTATGAACAAAAAAGGAGGTTTTGCATGA","10.30","22.75","49458","MENLENYYGRLLTENQMNSDLKKQAKILPAMIKKPHYFICNRCGSQNNLGNALPDGSIYCRACLVFGRLTNRDSLYYFEQKPFPKGQVLRWQGQLTPFQQEVSRGLKKSVCHKENMLIHAVTGAGKTEMIYETLASILNQGGAVALASPRIDVCIELYKRLSRDFSCPISLLYGESEAYERSPLVIATTHQLLKFYRAFDLLIIDEVDAFPFVDNKMLYYAVDHCLKSDGVKVFLTATSTDQLDKQVKQGKLKKLHLARRFHANPLVVPKPIWLNLSLERLQRGKLPRSFLQQIRIQRQTQFPLLIFFPNIEDGLTFAKSLQTYLPNEKIDFVSSLTTDRLEKVENFRKGNTQILVSTTILERGVTFPCVDVFVMMSNHYLFTKSSLVQIAGRVGRSADRPDGKLLFFHNGMNRAMKKAIMEIKTMNKKGGFA","468416","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). ","late competence protein F","Cytoplasm","Matches in gapped BLAST to late competence proteins and to helicases. Residues 6-431 are 59% similar to gi15904054 from S.pneumoniae. Residues 1-430 are 50% similar to gi15675494 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0336 (1e-148).","

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[322-398]T$	Helicase_C
SM00490	$\"[315-398]T$	HELICc
PS51194	$\"[290-433]T$	HELICASE_CTER

InterPro
IPR011545
Domain

DEAD/DEAH box helicase, N-terminal
PF00270	$\"[96-246]T$	DEAD

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[91-273]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[107-257]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[267-424]T$	G3DSA:3.40.50.300
PTHR11752	$\"[96-207]T$	PTHR11752
SSF57783	$\"[40-87]T$	SSF57783

","BeTs to 3 clades of COG1200COG name: RecG-like helicasesFunctional Class: L,KThe phylogenetic pattern of COG1200 is -----qvcebrhuj--ol--xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 17:33:38 2006","Wed Sep 6 17:33:38 2006","Wed Sep 6 17:33:38 2006","Thu Apr 4 10:09:16 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0451 is paralogously related (blast p-value < 1e-3) to SMu1669, a predicted recG protein, and to SMu0006, a predicted transcription-repair coupling factor.","Tue Feb 12 13:15:10 2002","","No significant hits to the NCBI PDB database.","SMU.498","","Residues 87 to 277 (E-value = 4.4e-05) place SMu0451 in the DEAD family which is described as DEAD/DEAH box helicase (PF00270)Residues 322 to 398 (E-value = 2e-12) place SMu0451 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)","Wed Sep 6 17:33:38 2006","24378982","","Li YH, Tang N, Aspiras MB, Lau PC, Lee JH, Ellen RP, Cvitkovitch DG. A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation.J Bacteriol. 2002 May;184(10):2699-708.PMID: 11976299","Liu J, Zuber P.A molecular switch controlling competence and motility: competence regulatory factors ComS, MecA, and ComK controlsigmaD-dependent gene expression in Bacillus subtilis.J Bacteriol. 1998 Aug;180(16):4243-51.PMID: 9696775Londono-Vallejo JA, Dubnau D.comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.Mol Microbiol. 1993 Jul;9(1):119-31.PMID: 8412657","Fri Oct 25 15:15:10 2002","Tue Feb 12 13:19:00 2002","1","","","SMU.498","262" "SMu0452","468416","469081","666","ATGAACTGTCTCATTTGTCACTTGCCTTTTGAGAGTAAATATTATTTCTATTCTATTTTCTTCTTGAAAACTTCAAGAGATTTTGTTTGCCCACCTTGCTTTGCGAAATTTCAATTCGTATCTGAAAAACATTGCCTAAATTGTTATAAGGAGGGAGAAGGAGATATCTGTCAAGATTGCCACAAATGGCAAAATCTCAAAAAGGAGGTTCATCACAAGGCTCTCTTTTGTTACAATCAAGCTATGAAAGATTATTTCAGTGCTTACAAATTTCAAGGGGATTATCTTTTAAGAAAGGTCTTTATAAAGCCTATTAAAGAAGCCTTAAGAGAGTATACTAATTATACTTTGGTTCCCATTCCACTCAGCTCTTCAAGTTTAGAGAATCGTGGTTTTAATCAAGTGCAAGCTTTTTTAGATGAGGCAAAATTGTCTTATCATGATTTATTAGGCAAAGAAGATGGTAGTGTAAAACAATCAAGTAAAACACGTCAAGAACGCCTAAAGACTCAACAAAACTTTTATTTAAGGAAACATAAAGAATTACCTGATAAAGTGATGCTAGTTGATGATATCTATACAACGGGTATGACAATTCAATTGGCCAGTCAATTATTGCGTGAAAATGGTGTGAAAACAATAAAATCCTTTTCTTTAGCAAGGTAA","9.10","10.25","26002","MNCLICHLPFESKYYFYSIFFLKTSRDFVCPPCFAKFQFVSEKHCLNCYKEGEGDICQDCHKWQNLKKEVHHKALFCYNQAMKDYFSAYKFQGDYLLRKVFIKPIKEALREYTNYTLVPIPLSSSSLENRGFNQVQAFLDEAKLSYHDLLGKEDGSVKQSSKTRQERLKTQQNFYLRKHKELPDKVMLVDDIYTTGMTIQLASQLLRENGVKTIKSFSLAR","469078","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0451 (comF); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). Although associated with comF function, this protein does not appear to be paralogous to SMu0451, a predicted comF.","late competence protein required for DNA uptake","Cytoplasm","Matches in gapped BLAST to comF-related proteins and to proteins involved in DNA uptake. Residues 1-221 are 44% similar to gi|15902014, a predicted comF protein from S.pneumoniae and are 45% similar to gi|15673071, a predicted comFC protein from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0337 (1e-54).","

noIPR
unintegrated

unintegrated
SSF53271	$\"[44-221]T$	SSF53271

","BeTs to 8 clades of COG1040COG name: Predicted amidophosphoribosyltransferasesFunctional Class: RThe phylogenetic pattern of COG1040 is -----qvcebrh----ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 23 18:11:57 2002","Tue Feb 12 13:20:38 2002","Wed Oct 23 18:11:57 2002","Thu Apr 4 10:10:14 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0452 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 13:25:30 2002","","No significant hits to the NCBI PDB database.","SMU.499","","No significant hits to the Pfam 11.0 database","Tue Feb 12 13:20:38 2002","24378983","","","","","","1","","","SMU.499","759" "SMu0453","469160","469708","549","ATGATTAAATATAGTATTCGTGGTGAAAACATCGAGGTAACAGATGCAATCCGTAACTATGTTGAGTCTAAACTCAAGAAGATTGAAAAGTATTTCAATGCTGAACAAGAGTTGGATGCACGTATCAATCTGAAAGTATATCGTGAGAAAACAGCTAAAGTTGAAGTCACTATTCCTCTTGCTCCCGTTACTCTTCGTGCAGAGGATGTTTCACAAGATATGTATGGTTCTATTGATTTAGTTGTTGATAAGATTGAACGTCAGATTCGTAAAAATAAAACTAAAATTGCTAAGAAGCATCGTGAAAAGAAACCAGCGGCACATGTCTTTACAGCTGAATTTGAAGCAGAAGAGATGGAAGAGGCTCCAGCTATAAAGGTTGTCAGAACCAAAAACATCACTTTAAAACCTATGGATATCGAAGAGGCTCGTTTACAAATGGATCTCTTAGGTCACGATTTCTTCATCTACACAGATGCTAATGATAATACAACAAATGTTCTCTATCGTCGTGAAGATGGTAATTTGGGTCTTATTGAAGCAAAATAA","6.80","-0.26","21071","MIKYSIRGENIEVTDAIRNYVESKLKKIEKYFNAEQELDARINLKVYREKTAKVEVTIPLAPVTLRAEDVSQDMYGSIDLVVDKIERQIRKNKTKIAKKHREKKPAAHVFTAEFEAEEMEEAPAIKVVRTKNITLKPMDIEEARLQMDLLGHDFFIYTDANDNTTNVLYRREDGNLGLIEAK","469705","","ribosome-associated protein","Cytoplasm","Matches in gapped BLAST to conserved hypotheticals and to ribosomal subunit interface proteins. Residues 1-182 are 77% similar to gi15675492 from S.pyogenes and 72% similar to gi15902013 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0338 (2e-76).","

InterPro
IPR003489
Domain

Sigma 54 modulation protein/ribosomal protein S30EA
PF02482	$\"[3-99]T$	Ribosomal_S30AE
TIGR00741	$\"[2-103]T$	yfiA

noIPR
unintegrated

unintegrated
G3DSA:3.30.160.100	$\"[2-111]T$	G3DSA:3.30.160.100
SSF69754	$\"[2-111]T$	SSF69754

","BeTs to 8 clades of COG1544COG name: Ribosome-associated protein Y (PSrp-1)Functional Class: KThe phylogenetic pattern of COG1544 is -----qvcEbrh----o--nxNumber of proteins in this genome belonging to this COG is 1","***** IPB003489 (Sigma 54 modulation protein / S30EA ribosomal protein) with a combined E-value of 5.3e-34. IPB003489A 2-27 IPB003489B 55-95","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 12 13:30:12 2002","Tue Feb 12 13:26:42 2002","Tue Jul 25 12:05:20 2006","Tue Jul 25 12:05:20 2006","Tue Feb 12 13:26:42 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0453 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 13:30:12 2002","","No significant hits to the NCBI PDB database.","SMU.500","","Residues 3 to 99 (E-value = 8.3e-29) place SMu0453 in the Ribosomal_S30AE family which is described as Sigma 54 modulation protein / S30EA ribosomal protein (PF02482)","Tue Feb 12 13:26:42 2002","24378984","","","","","","1","","","SMU.500","639" "SMu0454","469832","470926","1095","ATGAATAAAGAGGATTGGTTGGATTATTTTGAAGCCATTAATGGTCGTGAGCCGTCTGCTAAAGAGATTGCAGAGGCTTTAGCCATAGGAGAATTTCAAGATGACGCTACTACAGACGTTGCTTTTGAAGAAAGCAGTAGTAACGACACGGTTGCTGAAGTTGTAGAAGAAAAAGAAGCTTCATCAATTGGGGCTGATCCGATTGCTTATCCTAAAGAACAAATGCCCCTTGCTCATTCAAATAACATTGCTAACTCTAAGCAGCAGGTAGAACAGTTAAAAGAAAAGGGGAAAAATTATTTAAGTTGGTTTTTAGAAGGTTTGAAGCATCCTGTTGCCGAGTCTTCAAATAGTCAATTTATTTATGGTTTAATCACACTCTTTCTTGCTGCTGTTCTTTTAGCAGCTGGTCTGGTCAATTATATCAATAGAATCTTTACTTCTATTATTAATATGACAGTCAGTGGTGAGAGTCTAAAGCTCAAAGAACCAGAGACTTTTTCTATGATTGAAGATGCCATTCGTACCAATTTTGGTTTTAGTAAAGTCATTGTTGTGACTCTCATTATTTTCCTTGCTTATGCCATTTTGGCTGTTTTGCCAGCATTCATTAACAAATTTACTTCAAAATCTCAAGAGAATGTGACGGAATTGTTAGGAAAATATGTTGCTTATACACCATTGTTAGCAGTCGTTAATTTTCTAATTTTAGTTGTCAGTTTTTTCACATCAGATAAATTAGTGGTTTCAAGTAAATATGCCTATCAAATTGCATCTTCATTTGAAACAGTTGCTTCTAGTCCTTCTGAAGGTTTGTCTTCTGTTTCTCGTTTAATCAAAGAAGTTCCAGCCATTCATTCTATTCAAACAGTATGTGTTTATTTAACGATTTTAAGTATTATTAGTTTAGCTGTTTTATTGGTAGCTTTCTTAAAAAATATCAAGGTTTCTATTGGAACTTTAAATAATTTCTATGTTACGTTGATATCATTTCTTGTTTTTATCTTAATTATTTTCTTTATGGATAAATCGCTGCTATCAAATCTTTTACATGGATTAGATAGCCTCAAAGACTCTCTAGCAAAATTATTTTAG","4.80","-10.06","40111","MNKEDWLDYFEAINGREPSAKEIAEALAIGEFQDDATTDVAFEESSSNDTVAEVVEEKEASSIGADPIAYPKEQMPLAHSNNIANSKQQVEQLKEKGKNYLSWFLEGLKHPVAESSNSQFIYGLITLFLAAVLLAAGLVNYINRIFTSIINMTVSGESLKLKEPETFSMIEDAIRTNFGFSKVIVVTLIIFLAYAILAVLPAFINKFTSKSQENVTELLGKYVAYTPLLAVVNFLILVVSFFTSDKLVVSSKYAYQIASSFETVASSPSEGLSSVSRLIKEVPAIHSIQTVCVYLTILSIISLAVLLVAFLKNIKVSIGTLNNFYVTLISFLVFILIIFFMDKSLLSNLLHGLDSLKDSLAKLF","470923","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu0454 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[120-142]?$ $\"[184-204]?$ $\"[223-243]?$ $\"[291-311]?$ $\"[321-341]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[154-174]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[10-30]?$	transmembrane_regions

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[192-198]?$	N6_MTASE

InterPro
IPR002294
Family

N6 adenine-specific DNA methyltransferase, D12 class
PR00505	$\"[18-34]T$ $\"[40-54]T$ $\"[59-72]T$ $\"[189-201]T$	D12N6MTFRASE

InterPro
IPR012263
Family

Adenine modification methylase, M.EcoRV
PIRSF000398	$\"[12-285]T$	M_m6A_EcoRV

InterPro
IPR012326
Domain

DNA adenine methylase
TIGR00571	$\"[12-282]T$	dam

InterPro
IPR012327
Domain

D12 class N6 adenine-specific DNA methyltransferase
PF02086	$\"[18-265]T$	MethyltransfD12

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[2-285]T$	G3DSA:3.40.50.150
SSF53335	$\"[11-285]T$	SSF53335

","BeTs to 6 clades of COG0338COG name: Site-specific DNA methylase damFunctional Class: LThe phylogenetic pattern of COG0338 is -m-k---Ce--huj---l---Number of proteins in this genome belonging to this COG is 1","***** PR00505 (D12 class N6 adenine-specific DNA methyltransferase signature) with a combined E-value of 2.7e-25. PR00505A 18-34 PR00505B 40-54 PR00505C 59-72 PR00505D 189-201","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 08:27:43 2002","Thu Oct 10 14:55:26 2002","Wed Sep 27 11:59:32 2006","Wed Sep 27 11:59:32 2006","Fri Feb 22 08:24:16 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0457 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 22 08:27:43 2002","Wed Sep 27 11:59:32 2006","pdb2DPMA Chain A, Dpnm Dna Adenine Methyltransferase From Str... 404 9e-114","SMU.504","","Residues 18 to 265 (E-value = 3.4e-94) place SMu0457 in the MethyltransfD12 family which is described as D12 class N6 adenine-specific DNA methyltransferase (PF02086)","Fri Feb 22 08:24:16 2002","24378988","","","Hiraga S.Dynamic localization of bacterial and plasmid chromosomes.Annu Rev Genet. 2000;34:21-59. Review.PMID: 11092821 Tran PH, Korszun ZR, Cerritelli S, Springhorn SS, Lacks SA.Crystal structure of the DpnM DNA adenine methyltransferase from the DpnII restriction system of streptococcus pneumoniae boundto S-adenosylmethionine.Structure. 1998 Dec 15;6(12):1563-75.PMID: 9862809 ","","Fri Feb 22 08:33:33 2002","1","","","SMU.504","" "SMu0458","474477","475286","810","ATGATGAATAACGAATATAAGTATGGGGGTATTTTTATGACAAAGCCATACTATTACAAAAATAAAACTATTTTAGTTCATGCTGATACATTCCAATTTTTAGAAAAGATGAAATCTGAAAGTATAGATATGATATTTGCAGATCCGCCATATTTTCTTAGTAATGGAGGTTTTTCTAATTCGGGTGGTCAAGTGGTTTCAGTTGATAAAGGTGATTGGGACAAAGCTGCTTCTCTTGAGGAAAAACATGAATTTAATCGTCGTTGGATAAGACTAGCTAAAAAGGTTTTGAAGTCAAATGGAACTATCTGGATATCAGGAAGTTTGCATAATATTTATTCTGTTGGTATGGCTTTGGAACAAGAAGGATTTAAAATTTTAAATAATATTACCTGGCAGAAAACTAATCCAGTACCAAATCTATCTTGTCGTTATTTCACACATTCAACAGAAACTATTCTGTGGGCACGTAAAAATGATAAAAAATCAAAACATTATTATAATTATGATTTGATGAAAAAAATCAATGATGGTAAACAGATGAAGGATGTCTGGACGGGAAGTCTAACTAAAAAGTCCGAAAAATGGGCTGGGAAACACCCAACTCAAAAGCCAGAATATTTATTAGAACGAATCATCTTGGCCAGCACTAAGAAAGGAGATTATATATTAGATCCTTTTGTCGGGAGTGGTACAACTGGAGTGGTGGCTAAAAAGCTTGGTAGACGATTTATCGGCATTGATTCAGAACGAGAATATTTAAGAATTGCACGTACAAGATTGGAGAGAGTAGATGGTCAATACTGTTGA","10.40","16.35","31132","MMNNEYKYGGIFMTKPYYYKNKTILVHADTFQFLEKMKSESIDMIFADPPYFLSNGGFSNSGGQVVSVDKGDWDKAASLEEKHEFNRRWIRLAKKVLKSNGTIWISGSLHNIYSVGMALEQEGFKILNNITWQKTNPVPNLSCRYFTHSTETILWARKNDKKSKHYYNYDLMKKINDGKQMKDVWTGSLTKKSEKWAGKHPTQKPEYLLERIILASTKKGDYILDPFVGSGTTGVVAKKLGRRFIGIDSEREYLRIARTRLERVDGQYC","475283","","adenine-specific DNA methylase (DpnIIB)","Membrane, Cytoplasm","Several matches to methylases in gapped BLAST. Residues 1-267 are 80% similar to gi15281345 from S.suis. Residues 1-262 are 83% similar to gi127389 from S.pneumoniae.SMu0458 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001091
Family

Site-specific DNA-methyltransferase (cytosine-N4-specific)
PR00508	$\"[41-55]T$ $\"[89-109]T$ $\"[200-217]T$ $\"[219-237]T$ $\"[242-262]T$	S21N4MTFRASE

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[45-51]?$	N6_MTASE

InterPro
IPR002295
Family

N6 adenine-specific DNA methyltransferase, D21 class
PR00506	$\"[42-54]T$ $\"[89-108]T$ $\"[200-222]T$ $\"[223-237]T$	D21N6MTFRASE

InterPro
IPR002941
Domain

DNA methylase N-4/N-6
PF01555	$\"[42-259]T$	N6_N4_Mtase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[24-264]T$	G3DSA:3.40.50.150
SSF53335	$\"[11-266]T$	SSF53335

","BeTs to 5 clades of COG0863COG name: Adenine-specific DNA methylaseFunctional Class: LThe phylogenetic pattern of COG0863 is -M-k--v-e--hUJ-------Number of proteins in this genome belonging to this COG is 1","***** PR00506 (D21 class N6 adenine-specific DNA methyltransferase signature) with a combined E-value of 2e-41. PR00506A 42-54 PR00506B 89-108 PR00506C 200-222 PR00506D 223-237***** IPB001091 (N-4 DNA methylase (N4-MTase)) with a combined E-value of 1.7e-13. IPB001091A 39-51 IPB001091B 223-233","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 08:39:04 2002","Fri Feb 22 08:42:55 2002","Wed Sep 27 12:00:07 2006","Wed Sep 27 12:00:07 2006","Fri Feb 22 08:35:39 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0458 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 22 08:39:04 2002","Wed Sep 27 12:00:07 2006","pdb1EG2A Chain A, Crystal Structure Of Rhodobacter Spheroides... 76 5e-015","SMU.505","","Residues 93 to 261 (E-value = 2.2e-72) place SMu0458 in the N6_N4_Mtase family which is described as DNA methylase (PF01555)","Fri Feb 22 08:35:39 2002","24378989","","","Sekizaki,T., Osaki,M., Takamatsu,D. and Shimoji,Y.Distribution of the SsuDAT1I Restriction-Modification System amongDifferent Serotypes of Streptococcus suisJournal of bacteriology. 183 (18), 5436-5440 (2001)PubMed: 11514530Lacks,S.A., Mannarelli,B.M., Springhorn,S.S. and Greenberg,B.Genetic basis of the complementary DpnI and DpnII restrictionsystems of S. pneumoniae: an intercellular cassette mechanismCell 46 (7), 993-1000 (1986)PubMed: 3019562de la Campa,A.G., Kale,P., Springhorn,S.S. and Lacks,S.A.Proteins encoded by the DpnII restriction gene cassette. Twomethylases and an endonucleaseJ. Mol. Biol. 196 (3), 457-469 (1987)PubMed: 2824782","","Fri Feb 22 08:42:55 2002","1","","","SMU.505","" "SMu0459","475270","476208","939","ATGGTCAATACTGTTGATGACAACTTGAAATATAGTGTTTTTGATTACCTTAATTTATCCTCAGAGGCAAAATTAGAGTTTTTCATGGAGACGCGTTCATCATTGAGTTTTCTTGCTTCTTACTGGTTTGATTTTGATAATGTTAAAGCTAATATTTCAAACTATGATGAGCCAGATTTGTATACTTTGGATTATTTAATTGGAAAATCAGATCAAGAGATTGACAATTTTTTTAAAAAACGCCCCAACTTATTATTGTTAGTCCCTAAACTTTTAGGGATTAGGGATAGTAAATTTGAAAAACCGATTCGAAATAGAATTTTAAAAGTTCAAGATGTCTCAGGTGTTTATACCTTAAATTTTAAAGATATTGATTTGAGTAAACTAGATCTCTATCTTCAATTCATTCATGACAGTGGTTTAGATTGGGTTTTCAAAATTGGATTAAGAAAGTCAGTTCATGATTATGTTGTTGGAGTGGAGGCTGGTATGGACTCTAATGGTCGAAAAAATAGAAGTGGAGATATGGGGGAACTCTATTTGGAAACGGCTTTAAAAAAGATTGCTAAAGAAAAGGCCTGGTTAGCTCATGGGCAGTCAACCCGTAGCAGTATCAAAAATTGGTATGGAATTGATTTGGATAAAAGTTTTGAAAATCGTCGTTTTGACGGGTCATTATTTAATCCTGTAAGGAAGAAATTATATTTATTTGAGGTAAATAATTTCAATTCTAGTGGCTCTAAATCCAAGGCTTCAGCAACCGAATTTAAAGATTTACATGATAGATTCAGTAGAACCAATCATGAGTTCATTTACATTACAGATGGTAAAGGTTGGGATAGTGATAAATCGCATTTAATGGAAGCCATGAAATACATTGGTAAAGTTTTTAATTATAAAATGATTGAATCGGATTATTTAAATGATTATCTTGAATAA","6.80","-0.54","36375","MVNTVDDNLKYSVFDYLNLSSEAKLEFFMETRSSLSFLASYWFDFDNVKANISNYDEPDLYTLDYLIGKSDQEIDNFFKKRPNLLLLVPKLLGIRDSKFEKPIRNRILKVQDVSGVYTLNFKDIDLSKLDLYLQFIHDSGLDWVFKIGLRKSVHDYVVGVEAGMDSNGRKNRSGDMGELYLETALKKIAKEKAWLAHGQSTRSSIKNWYGIDLDKSFENRRFDGSLFNPVRKKLYLFEVNNFNSSGSKSKASATEFKDLHDRFSRTNHEFIYITDGKGWDSDKSHLMEAMKYIGKVFNYKMIESDYLNDYLE","476205","","type II restriction endonuclease","Cytoplasm, Extracellular","Numerous matches in gapped BLAST to type II restriction endonucleases. Residues 9-312 are 74% similar to gi5420083 of S.thermophilus. Residues 16-309 are 35% similar to the SsuRB enzyme of S.suis (gi12082204).SMu0459 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007637
Family

Restriction endonuclease, DpmII
PF04556	$\"[23-311]T$	DpmII

noIPR
unintegrated

unintegrated
PD013965	$\"[59-305]T$	PD013965

InterPro
IPR001034
Domain

Bacterial regulatory protein, DeoR N-terminal
PR00037	$\"[24-38]T$ $\"[38-56]T$	HTHLACR
PF08220	$\"[6-62]T$	HTH_DeoR
SM00420	$\"[6-58]T$	HTH_DEOR
PS00894	$\"[6-40]T$	HTH_DEOR_1
PS51000	$\"[3-58]T$	HTH_DEOR_2

InterPro
IPR014036
Domain

Bacterial regulatory protein, DeoR
PF00455	$\"[76-229]T$	DeoR

noIPR
unintegrated

unintegrated
SSF100950	$\"[73-233]T$	SSF100950
SSF46785	$\"[2-81]T$	SSF46785

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[7-268]T$	Cof-subfamily
PS01229	$\"[222-244]T$	COF_2

InterPro
IPR001757
Family

ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119	$\"[9-23]T$ $\"[222-241]T$	CATATPASE

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[7-241]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[8-268]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[1-272]T$	G3DSA:3.40.50.1000
PTHR10000	$\"[190-253]T$	PTHR10000
SSF56784	$\"[1-274]T$	SSF56784

","BeTs to 12 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class:� RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","***** IPB000150 (Cof protein) with a combined E-value of 1.6e-24. IPB000150A 4-18 IPB000150B 38-47 IPB000150C 220-252***** IPB001757 (E1-E2 ATPases) with a combined E-value of 6.1e-06. IPB001757A 8-19 IPB001757B 213-242","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 12:09:40 2002","Thu Oct 10 15:02:39 2002","Fri Feb 22 12:09:40 2002","Fri Feb 22 12:06:58 2002","Fri Feb 22 12:06:58 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0461 is paralogously related (blast p-value < 1e-3) to SMu1666, SMu0388, SMu0655, SMu0675, SMu1012, SMu0442, SMu0674, SMu0367, SMu1161, and SMu1867, mostly conserved hypothetical proteins, some with possible hydrolase function.","Fri Feb 22 12:09:40 2002","","No significant hits to the NCBI PDB database.","SMU.508","","Residues 5 to 245 (E-value = 8e-11) place SMu0461 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Fri Feb 22 12:06:58 2002","24378992","","","","","","1","","","SMU.508","" "SMu0462","478383","479447","1065","ATGTCTTTTGAATCTGACTTTTTTAAGAAAAAACGCGTTCGTTTTGAGACCTTATCTGCCTTTGGTTTTGTTAAAATAGGGCAGGACTATCTCTATAAAGAAATTTTTATGGCAGGTGATTTTGAAGCTCAAGTTAAGATTTCTGAGTCTGGACAGGTGTCAGGTCGAGTACTGGATAGGGATACAGATGATGATTATCTTGCACTGCGTGTCGAAAGACAGGTAGGAACTTTTGTTGGTCAGGTTCGACAAGCTTATACAGAAATTTTAAGTCGAATTGCAGATGCTTGTTTTGAAGCTCTGCCTTTTATTAAAAATCAAACCAACCGTTTGGCCCAATATATTGCAAAGAAATATGGTGATGCTTGTGACCATCCTTTTGCCAAGTATCCAGCTTTTTCTTCCTATCGTCATCCGGATAATCACAAATGGTATGCACTGATTATGGCTATTGCGCGTGGTAAGTTAGACTTAGGAAAGGAAGAGTGGGAGAAAGAAGAATTGGATCAGCAGGTAGAAATCATCAATCTTAAGATCAATCCTGCTGATATGTCTCGTTTACTTACTATTTCTGGTATTTATCCTTCTTATCATATGAACAAGAAATCTTGGATTTCTCTTGTTTTAGATGAGCAGGTTTCTGATAATTTTCTTTTTTCTTTGGTGGACAATAGCAGAGCTTTGACTGCCGGAAAGGCCCTAGGGAATCCTGATGGGCCTGATTACTGGATTATTCCAGCTAATCTTAAATATTATGACATTGATGCCGAATTTGCAAGCTACCAAATAGTTGAATGGCCTCAAAAGGCCAGTATTAAAGCAGGTGATTATCTTTTTATTTACATTACGGCACCAACGCGTGCCTTGCGCTATGCTTGTCGGGTAGTAGAAGCAGGTATAGAAGGATGGCATTCAGATAAAAAAAAGATGAGACTAGAATTGTTGAAAAAATATGATGACGGCAATTTTCCCATCGAGCGTCTCAAAAAATATGGTGTTACCAATATTCGCGGTCCACGTCGCATGACTAAAGAACTCATTAATCAAGTCAAGAAAAGTTTGTAA","9.00","5.08","40839","MSFESDFFKKKRVRFETLSAFGFVKIGQDYLYKEIFMAGDFEAQVKISESGQVSGRVLDRDTDDDYLALRVERQVGTFVGQVRQAYTEILSRIADACFEALPFIKNQTNRLAQYIAKKYGDACDHPFAKYPAFSSYRHPDNHKWYALIMAIARGKLDLGKEEWEKEELDQQVEIINLKINPADMSRLLTISGIYPSYHMNKKSWISLVLDEQVSDNFLFSLVDNSRALTAGKALGNPDGPDYWIIPANLKYYDIDAEFASYQIVEWPQKASIKAGDYLFIYITAPTRALRYACRVVEAGIEGWHSDKKKMRLELLKKYDDGNFPIERLKKYGVTNIRGPRRMTKELINQVKKSL","479444","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-352 are 46% similar to gi|15675448 from S.pyogenes. Residues 6-232 are 36% similar to gi|15903181 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0449 (5e-96).","

InterPro
IPR007351
Family

Protein of unknown function DUF419
PF04237	$\"[115-230]T$	DUF419

noIPR
unintegrated

unintegrated
PS51257	$\"[1-19]T$	PROKAR_LIPOPROTEIN

noIPR
unintegrated

unintegrated
PTHR18895	$\"[67-131]T$	METHYLTRANSFERASE
PTHR18895:SF2	$\"[67-131]T$	RNA METHYLTRANSFERASE
signalp	$\"[1-28]?$	signal-peptide
tmhmm	$\"[12-32]?$	transmembrane_regions

","BeTs to 3 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class:� RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 12:21:59 2002","Fri Feb 22 12:20:58 2002","Fri Feb 22 12:21:59 2002","Fri Feb 22 12:20:58 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0464 is paralogously related (blast p-value < 1e-3) to SMu0563, a conserved hypothetical protein.","Fri Feb 22 12:21:59 2002","","No significant hits to the NCBI PDB database.","SMU.512c","","No significant hits to the Pfam 11.0 database","Fri Feb 22 12:20:58 2002","24378995","","","","","","1","","","SMU.512c","" "SMu0465","481136","481369","234","ATGAATACACTAACATTAGATTCAATGGCATTTGACAATTTTGAAATTGCTAACAATGAATATCTTGCTACTACCGAAGGAGAAGGTTTAGGTTCGGTCCTCTGGGGTGGGACTGTTGAAGAACTTGATAAGGCCTTTACTTGGGGAGCAGCAGCTGCCTTAGCAATAGGAGTTATTGCTATCAATGTGGGGCTTGCGGCAGGATATTGCTATAATAATAATGATGTCTTCTAA","3.40","-9.06","8094","MNTLTLDSMAFDNFEIANNEYLATTEGEGLGSVLWGGTVEELDKAFTWGAAAALAIGVIAINVGLAAGYCYNNNDVF","481366","","hypothetical protein","Extracellular","No significant matches in gapped BLAST.SMu0465 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[51-71]?$	transmembrane_regions

InterPro
IPR000215
Family

Proteinase inhibitor I4, serpin
PS00284	$\"[84-94]?$	SERPIN

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[16-55]T$	TetR_N
PS50977	$\"[3-63]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[2-70]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[2-66]T$	Homeodomain-rel

","BeTs to 4 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 1.2e-06. IPB001647 21-51","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 12:27:24 2002","Fri Feb 22 12:24:57 2002","Tue Mar 6 14:12:02 2007","Tue Mar 6 14:12:02 2007","Fri Feb 22 12:24:57 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0466 is paralogously related (blast p-value < 1e-3) to SMu1440, SMu1936, SMu0398, SMu1750, SMu1171, SMu1069, and SMu1139, all predicted transcriptional regulators.","Fri Feb 22 12:29:44 2002","","No significant hits to the NCBI PDB database.","SMU.514","","No significant hits to the Pfam 11.0 database","Fri Feb 22 12:24:57 2002","24378997","","","","","","1","","","SMU.514","" "SMu0467","482277","484052","1776","ATGTATTATTCAAGTGGAAATTATGAAGCTTTTGCTCGCCCTAGAAAACCTGCAGGTGTTGAACACAAATCGGCTTATATTATTGGTTCTGGTTTGGCCGCTCTGTCTGCTGCCTGTTTTCTAGTTCGCGATGGACAAATGCCCGGTAAACAAGTGCATATTTTGGAAAAAGATCCCATTCCTGGTGGTGCTTGTGATGGTTATCAATACAGTGATATTGGTTATGTGATGCGTGGCGGTCGTGAGATGGACAATCATTTTGAATGTATGTGGGACTTATTTCGTTCAATTCCGTCTATTGAAACGGAAGGCGTAAGTGTTCTTGATGAATATTACTGGCTCAATAAAGCAGACCCCAACTATTCGCTTTGCCGTGCAACGAAAAAGCAAGGACAAGATGCCCATACTGATAAAAAATTTACCTTGTCCGATAAAGGGGCCAAAGAGATTATGCATTTATTCTTCACACCAGACGAAGATTTATATAATAAACGTATTAACGAAGTTTTTGATGGTGAAGTCTTTGATTCTAATTTCTGGCTTTATTGGCGGACAATGTTTGCTTTTGAAAATTGGCATTCTGCCTTAGAAATGAAACTTTATCTGAAGCGCTTCATTCATCATATTAGTGGCTTGCCTGACTTTACGGCTTTGCGCTTCACAAAGTACAATCAATACGAATCGATGATTTTGCCAATGATCAAATATCTTGAGTCATTTGGGGTTGTGTTTCATTACAATACTAAGGTGGTTAATATTACATTTGATATTCAAAAAGATAAAAAAGCAGCTAAAAGTATCGCAGTGATTCGTGATGGCCAAGGCGAAAAAATTGACTTGACAGAAAATGATCTAGTTTTTATTACAAATGGCGGCTGTGTAGAAAATTCAAGCTATGGCAGTCAGGATAAAGCGGCAGTCTTTAATTGTGAGATTCGTGAAGGCGGTGGTTGGGATATGTGGCGTCAAATTGCTAAGCAAGATCCCTCTTTTGGGCATCCTGATAAATTCTGCTATGATCCTGAGCAGACAAATTGGATGAGCGCAACCGTGACAACTTTGGATGATAAGATTCCGCCATACATTCAAAAAATTTGTAAACGGGATCCATTCTCAGGAAAGATCGTGACAGGTGGTATTGTTACTGTTCGTGATTCTAATTGGTTAATGAGCTGGACCATCAATCGTCAGCCGCAATTCCATAACCAACCTAAAGATCAGCTGGTTGTTTGGGTTTATGCGCTCTTTTCTGATAAAGAAGGAGATTATATTAAAAAACCAATGAGGGATTGTACGGGAAAAGAAATATGCGCAGAATGGCTCTATCATTTAGGTGTTCCTCTATCAGAAATTGATGAAATGGCTAAAAAAAGTGCCAAGACTGTTCCTTGTATGATGCCCTATATTACAGCTTTCTTTATGCCAAGAGAAGAGGGAGATCGTCCAGATGTAGTTCCACAAGGTGCTGTTAATTTTGCCTTTTTAGGACAATTTGCACAAACAAAAAGAGATACAATCTTTACGACGGAATATTCTATTCGGACAGGGATGGAAGCTGTTTATACTTTGTTGAATGTGGATCGCGGTGTTCCAGAAGTTTGGGGAAGCACTTATGATATCCGTGATCTGTTGCATGCAGCAGTTGCCCTTCGTGATGGCAAAAAGATTACAGATATGAAATTAAATTTATCTGAAAAGATTGCACTAAAAGAATTATTGAAAAAAACTAAGGGGACAGATCTTGAAAAATTACTGAAAGATTATCATCTTGTTTAA","6.50","-4.10","67736","MYYSSGNYEAFARPRKPAGVEHKSAYIIGSGLAALSAACFLVRDGQMPGKQVHILEKDPIPGGACDGYQYSDIGYVMRGGREMDNHFECMWDLFRSIPSIETEGVSVLDEYYWLNKADPNYSLCRATKKQGQDAHTDKKFTLSDKGAKEIMHLFFTPDEDLYNKRINEVFDGEVFDSNFWLYWRTMFAFENWHSALEMKLYLKRFIHHISGLPDFTALRFTKYNQYESMILPMIKYLESFGVVFHYNTKVVNITFDIQKDKKAAKSIAVIRDGQGEKIDLTENDLVFITNGGCVENSSYGSQDKAAVFNCEIREGGGWDMWRQIAKQDPSFGHPDKFCYDPEQTNWMSATVTTLDDKIPPYIQKICKRDPFSGKIVTGGIVTVRDSNWLMSWTINRQPQFHNQPKDQLVVWVYALFSDKEGDYIKKPMRDCTGKEICAEWLYHLGVPLSEIDEMAKKSAKTVPCMMPYITAFFMPREEGDRPDVVPQGAVNFAFLGQFAQTKRDTIFTTEYSIRTGMEAVYTLLNVDRGVPEVWGSTYDIRDLLHAAVALRDGKKITDMKLNLSEKIALKELLKKTKGTDLEKLLKDYHLV","484049","","67 kDa myosin-crossreactive antigen","Cytoplasm","Matches in gapped BLAST to primarily 67 kDa myosin-crossreactive antigens. Residues 1-591 are 56% similar to gi|15923096 from S.aureus and 54% similar to gi|15672937 from L.lactis. Residues 1-591 are 52% similar to gi|15674587 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1508 (0.0).","

InterPro
IPR002160
Family

Proteinase inhibitor I3, Kunitz legume
PS00283	$\"[428-444]?$	SOYBEAN_KUNITZ

InterPro
IPR010354
Family

Streptococcal 67 kDa myosin-cross-reactive antigen like
PF06100	$\"[21-521]T$	Strep_67kDa_ant

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[22-256]T$	G3DSA:3.50.50.60
SSF51905	$\"[1-292]T$	SSF51905

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[114-120]?$	N6_MTASE

InterPro
IPR004398
Family

Conserved hypothetical protein 95
PF03602	$\"[1-178]T$	Cons_hypoth95
TIGR00095	$\"[1-179]T$	CHP95

InterPro
IPR005479
Domain

Carbamoyl-phosphate synthase L chain, ATP-binding
PS00867	$\"[79-86]?$	CPSASE_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[22-179]T$	G3DSA:3.40.50.150
SSF53335	$\"[3-119]T$	SSF53335

","BeTs to 10 clades of COG0742COG name: N6-adenine-specific methylaseFunctional Class: LThe phylogenetic pattern of COG0742 is ------vcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** PR00505 (D12 class N6 adenine-specific DNA methyltransferase signature) with a combined E-value of 6.3e-06. PR00505B 45-59 PR00505D 111-123","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 12:44:10 2002","Wed Jul 26 14:55:16 2006","Wed Jul 26 14:54:34 2006","Wed Jul 26 14:54:34 2006","Fri Feb 22 12:43:21 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0468 is paralogously related (blast p-value < 1e-3) to SMu0563, a conserved hypothetical.","Fri Feb 22 12:44:10 2002","","No significant hits to the NCBI PDB database.","SMU.516","","Residues 1 to 178 (E-value = 7.5e-90) place SMu0468 in the Cons_hypoth95 family which is described as Conserved hypothetical protein 95 (PF03602)","Fri Feb 22 12:43:21 2002","24378999","","","","","","1","","","SMU.516","647" "SMu0469","485165","485665","501","ATGTCAGATAGAATTGGACTCTTTGCAGGTTCTTTTGATCCTGTGACAAATGGACATGTGGATATTATTCGTCGTGCTAGCGGACTTTTTGATAAACTTTATGTTGGGCTTTTTTATAATAAAGATAAGACTGGCTTGTTTGAACCTGCTAGGCGGCAAATTATGCTGAAAGAGGCATTGGGTGATTTAAAAAATGTTGAAGTCGTTGCAGCTCGAGATAGTTTAGCAGTTGATATTGCCAGACAGCATCAGGTTACACATTTAGTTCGAGGGCTAAGAAATGCGCAAGATTTGGAGTATGAAGCTAATCTCGCCTTTTTCAATAGTCAATTAGCTAAAGAAATTGAAACTGTGTTTTTATTAACAGCTTTAGACTATCGTTATTTCAGTTCTAGTCGGATACGCGAGCTTATTCATTTTGGGGCAGACATCAGTCCTTATGTTCCGCAGGGAGTTGTAAAAGAAGTGGGGAAAAAATGTGAAAACAAACAAAAAATTTAA","9.10","2.91","18761","MSDRIGLFAGSFDPVTNGHVDIIRRASGLFDKLYVGLFYNKDKTGLFEPARRQIMLKEALGDLKNVEVVAARDSLAVDIARQHQVTHLVRGLRNAQDLEYEANLAFFNSQLAKEIETVFLLTALDYRYFSSSRIRELIHFGADISPYVPQGVVKEVGKKCENKQKI","485662","","phosphopantetheine adenylyltransferase; lipopolysaccharide core biosynthesis protein","Cytoplasm","Matches in gapped BLAST to lipopolysaccharide core biosynthesis proteins and phosphopantetheine adenylyltransferases. Residues 1-156 are 55% similar to gi15903825 from S.pneumoniae. Residues 1-161 are 63% similar to gi15675436 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0454 (5e-48).","

InterPro
IPR001980
Family

Coenzyme A biosynthesis protein
PR01020	$\"[4-22]T$ $\"[22-43]T$ $\"[51-75]T$ $\"[88-104]T$ $\"[115-137]T$	LPSBIOSNTHSS
TIGR01510	$\"[5-160]T$	coaD_prev_kdtB

InterPro
IPR004820
Domain

Cytidylyltransferase
PF01467	$\"[7-137]T$	CTP_transf_2

InterPro
IPR004821
Domain

Cytidyltransferase-related
TIGR00125	$\"[5-65]T$	cyt_tran_rel

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[4-162]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
PTHR21342	$\"[3-165]T$	PTHR21342
SSF52374	$\"[1-159]T$	SSF52374

","BeTs to 9 clades of COG0669COG name: Phosphopantetheine adenylyltransferaseFunctional Class: HThe phylogenetic pattern of COG0669 is -----qvcebrhuj--ol---Number of proteins in this genome belonging to this COG is 1","***** PR01020 (Lipopolysaccharide core biosynthesis protein signature) with a combined E-value of 7.2e-36. PR01020A 4-22 PR01020B 22-43 PR01020C 51-75 PR01020D 88-104 PR01020E 115-137","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 12:49:43 2002","Fri Feb 22 12:45:25 2002","Thu Jul 6 17:29:03 2006","Tue Oct 8 09:37:15 2002","Fri Feb 22 12:45:25 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0469 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 22 12:49:43 2002","Thu Jul 6 17:29:03 2006","pdb1B6TA Chain A, Phosphopantetheine Adenylyltransferase In C... 110 9e-026","SMU.517","","Residues 7 to 137 (E-value = 1.3e-18) place SMu0469 in the CTP_transf_2 family which is described as Cytidylyltransferase (PF01467)","Fri Feb 22 12:45:25 2002","24379000","","","Geerlof A, Lewendon A, Shaw WV.Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.J Biol Chem. 1999 Sep 17;274(38):27105-11.PMID: 10480925","","Fri Feb 22 12:51:28 2002","1","","","SMU.517","773" "SMu0470","485643","486683","1041","GTGAAAACAAACAAAAAATTTAAATGGTGGCTAATCAGCGGTATCAGTCTTATTTTGCTTTTAATGGTATTCTTTTTTCCTCTTCCTTACTATTTAGAAATGCCCGGCGGAGCCTATGATATTCGTTCTGTTGTGACGGTTAATCATAAAGAAGATAAAGAGAAAGGATCTTATAATTTTGTAGCTGTCTCTCTTAGTAAGGCAACCCCCATACAAGTCCTCTATGCTTGGTTGACCCCTTTTACAGAAATTACCAGTGCCAAGGAAACAACTGGTGGTGTTAGTGATGCGGATTATATGAGGATTAATCAGTTTTATATGGAAACCTCACAAAATGGAGCTATCTATAAAGCTCTTTCTTTAGCTCATAAAAAGGCAAGCTTTAATTATATGGGTGTTTATGTTTTGCAGGTTAGTAGGAATTCAACATTCAAGGGTGTTTTAAATATTGCTGATACTGTAACAGGCGTTAATGACAAGACCTTTCATAGTTCAAAAGAATTGATTAAATATGTGTCTGGACTGAAATTAGGCAGCAAGGTCAGTGTTCAATATACTTCTGAAAATAAGAAGAAAACAGCCAAGGGCAAAGTTATTAAATTGTCAAATGGCAAAAATGGTATTGGCATTGGCTTGGTTGATCATACCAAGGTCACTTCTGATGATAAAATCGAATTTAGCACAAATGGTATTGGAGGGCCAAGTGCCGGTCTCATGTTTACCCTTGATATTTACGATCAACTAGTGAAAGAGGACTTACGTAAGGGTCGTATTATTGCAGGTACTGGTACTATTGGAGAAGACGGGTCTGTTGGGGATATTGGCGGTGCCGATATGAAAGTGGCAGCAGCAGATAGGATTAATGCAGATATCTTTTTTGTTCCCAATAATCCTGTAAGTAAGGCAACTTTGAAAAAAAATCCCAAAGCTCTCACTAATTATCAAGAAGCTAAGCAGGCTGCTAAAAAATTAGGCACTAAGATGAAGATTGTCCCTGTTAAAAATGTGCAGGAGGCTATTGATTACCTAAGAAAACACTAA","10.40","18.20","37936","MKTNKKFKWWLISGISLILLLMVFFFPLPYYLEMPGGAYDIRSVVTVNHKEDKEKGSYNFVAVSLSKATPIQVLYAWLTPFTEITSAKETTGGVSDADYMRINQFYMETSQNGAIYKALSLAHKKASFNYMGVYVLQVSRNSTFKGVLNIADTVTGVNDKTFHSSKELIKYVSGLKLGSKVSVQYTSENKKKTAKGKVIKLSNGKNGIGIGLVDHTKVTSDDKIEFSTNGIGGPSAGLMFTLDIYDQLVKEDLRKGRIIAGTGTIGEDGSVGDIGGADMKVAAADRINADIFFVPNNPVSKATLKKNPKALTNYQEAKQAAKKLGTKMKIVPVKNVQEAIDYLRKH","486680","","conserved hypothetical protein","Periplasm, Membrane","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-345 are 67% similar to gi|15675435 from S.pyogenes. Residues 5-346 are 58% similar to gi|15901790 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0455 (1e-131).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[9-31]?$	transmembrane_regions

","BeTs to 3 clades of COG1750COG name: Archaeal serine proteasesFunctional Class:� RThe phylogenetic pattern of COG1750 is am-k-----------------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 22 14:30:46 2002","Fri Feb 22 14:30:46 2002","Fri Feb 22 14:30:46 2002","Fri Feb 22 14:30:46 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0470 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 22 14:30:46 2002","","No significant hits to the NCBI PDB database.","SMU.518","","No significant hits to the Pfam 11.0 database","Fri Feb 22 14:30:46 2002","24379001","","","","","","1","","","SMU.518","277" "SMu0471","486756","488087","1332","ATGAAAGAAAGTCTGCGTATTTTGCATATCAATGATTTACATTCTCACTTTGAAGCTTATCCAAAGATTAAGCGTTTTTTTGCTGAACATTCAAAAACACAGAGGGAAGTGTTAAGATTTGATATTGGTGATAATGTAGATAAAAGCCATCCTTTGACCGATGTGAGCGCTGGTAGGGTAAATGTTGATTTGATGAACGATCTAGGAATTGATTTTGCGACGATTGGCAATAATGAAGGCATTGGTCTAGCAAAGGCTGAAATCAATCAGCTTTATCATAAAGCTGACTTCCAAGTCATCTTAGGAAATTTGCGAGACAAAAAGGGACGTCCTACTTGGGCTCAGCCTTATGTCATTTATGAAACTAAAGCTGGGACAAAACTGGCACTTTTGGCTTACACTTTTCCTTACTATTGGACTTATGTGCCTAATGGTTGGCAAGTTCTTGATGCGATTTCCAGTCTTAAAAAAGATTTGGAAAATCCAGAGGTAGCGGCAGCAGATTTTCGTATTTTACTTAGCCATTTAGGCATTCGTTTAGATGAAAAAATAGCGCGTCAAGTTCCTGAAATTGATTTGATTATTGGCGCCCATACGCACCATGTCTTTGAAGAAGGTGAGGTTGTCAATGGCACTTATCTAGCAGCGGCAGGGCGTTACGGAGATCATGTGGGACAAATTGATTTGGATTTCGAAGATCATAGCTTGACGAATATCGCTATTGAAGCTGTGCCAACCAGTGATCTTGATTCGGAAAAAGAAGATGCGGCTTTTGTTGCCCATCTTTTTGAAGAAGGCGAAAAGTTGCTGGCAGAGAATTTGATCTGCAAATTATCTCGCCAACCAAGTTTGAAAGAGTGTGCAGATTTAGTGATGGAGGCAATGAAGAAGTCAGCTGCTGCAGATTTAGCTATTATAAACACAGGATTGGTTGTTGAGCCTTTTTCGCAAAATCTTACTAAGGCAGACCTTCACAAATCCTTACCCCATCAAATGCGTCTGGTCAAATTTCAAGTGACACAAACTGAACTCTTAGAAATCTGTCACGATATCTTTTCGCAAGCAGATTTATTAGCTAATCAGCAGATTCGTGGTATGGGCTTTCGCGGTAAACAGTTCGGCAAAGTAGTAACGAGTGGTTTTACTTACAAAAATGGAAAAATAGTGTATAATAATAAGGCTATTGGCAGAAAAGATAAAATGAGCCTTGTTTTAGTGGATCAATATTATTTTGCTCCTTATTTTAATAGCCTAACATCAAGAAAAGGACAATTGCTGTTTCCTGATTTACTGAGACAGACAGTAGAAAAATACCTGAGAGGAGATCTATGA","6.50","-4.26","49924","MKESLRILHINDLHSHFEAYPKIKRFFAEHSKTQREVLRFDIGDNVDKSHPLTDVSAGRVNVDLMNDLGIDFATIGNNEGIGLAKAEINQLYHKADFQVILGNLRDKKGRPTWAQPYVIYETKAGTKLALLAYTFPYYWTYVPNGWQVLDAISSLKKDLENPEVAAADFRILLSHLGIRLDEKIARQVPEIDLIIGAHTHHVFEEGEVVNGTYLAAAGRYGDHVGQIDLDFEDHSLTNIAIEAVPTSDLDSEKEDAAFVAHLFEEGEKLLAENLICKLSRQPSLKECADLVMEAMKKSAAADLAIINTGLVVEPFSQNLTKADLHKSLPHQMRLVKFQVTQTELLEICHDIFSQADLLANQQIRGMGFRGKQFGKVVTSGFTYKNGKIVYNNKAIGRKDKMSLVLVDQYYFAPYFNSLTSRKGQLLFPDLLRQTVEKYLRGDL","488084","","phosphodiesterase-related protein","Cytoplasm, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 5-440 are 42% similar to gi15672159 from L.lactis. Residues 1-432 are 37% similar to gi16080290 from B.subtilis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1941 (2e-08).","

InterPro
IPR004843
Domain

Metallophosphoesterase
PF00149	$\"[5-202]T$	Metallophos

InterPro
IPR006146
Domain

5'-Nucleotidase, N-terminal
PS00785	$\"[5-17]?$	5_NUCLEOTIDASE_1

InterPro
IPR006179
Family

5'-Nucleotidase and apyrase
PR01607	$\"[3-21]T$ $\"[165-182]T$ $\"[184-207]T$ $\"[212-232]T$	APYRASEFAMLY
PTHR11575	$\"[5-380]T$	5_nucleotidase

InterPro
IPR008334
Domain

5'-Nucleotidase, C-terminal
SSF55816	$\"[288-441]T$	5'-Nucleotdase_C

InterPro
IPR011240
Family

Phosphoesterase-related protein YunD
PIRSF036361	$\"[3-443]T$	YunD
PTHR11575:SF1	$\"[5-380]T$	Pesterase_YunD

noIPR
unintegrated

unintegrated
G3DSA:3.60.21.10	$\"[4-272]T$	G3DSA:3.60.21.10
SSF56300	$\"[4-272]T$	SSF56300

InterPro
IPR009370
Family

Protein of unknown function DUF1027
PF06265	$\"[26-112]T$	DUF1027

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 27-112 are 50% similar to a (PROTEOME COMPLETE YBIC YUTD) protein domain (PD068479) which is seen in Q9K7D1_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Feb 24 13:57:05 2002","Sun Feb 24 13:57:05 2002","Sun Feb 24 13:57:05 2002","Sun Feb 24 13:57:05 2002","","Sun Feb 24 13:57:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0472 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 13:57:05 2002","","No significant hits to the NCBI PDB database.","SMU.521","","Residues 26 to 112 (E-value = 3.1e-62) place SMu0472 in the DUF1027 family which is described as Protein of unknown function (DUF1027) (PF06265)","Sun Feb 24 13:57:05 2002","24379003","","","","","","1","","","SMU.521","774" "SMu0473","488629","489714","1086","ATGAAACCATCTATTTATAGTTTAACCCGTAATGATTTAATTGCTTGGACGATTGAACACGGTGAAAAAAAGTTCCGAGCCACACAGATTTGGGATTGGCTTTACCGTAAACGTGTTCAGTCTTTTGAGGAAATGACTAATCTTTCAAAAGATTTTATCGCCCTTTTAAATGAAAATTTCCTTGTCAATCCGCTCAAACAGCGTATCGTTCAAGAGTCAGCAGATGGGACAGTCAAGTATTTATTCGAGTTGCCAGATGGCATGTTAATTGAGACGGTGTTAATGCGTCAGCATTATGGTCTTTCTGTTTGTGTGACGACACAGGTAGGCTGTAACATTGGTTGTACTTTTTGCGCCAGTGGCTTGATCAAAAAGCAACGTGACCTTAATAATGGCGAAATTACAGCGCAGATTATGTTGGTGCAAAAATATTTTGATGAACGCGGTCAGGGTGAACGTATCAGTCATGTTGTGGTGATGGGAATTGGTGAACCTTTTGATAATTATGACAATGTGCTCAAATTCCTGCGTACAATAAATGATGATAATGGACTGGCAATTGGTGCTCGTCATATTACAGTGTCAACTTCAGGCTTAGCCCATAAAATTCGTGATTTTGCCAATGAAGGGGTTCAAGTCAATTTGGCTGTCTCACTTCACGCACCTAACAATGAATTGCGCTCTAGCATTATGCGCATCAATCGTTCTTTTCCTTTGGAAAAACTATTTGCAGCCATTGAATATTATATTGAAACGACCAACCGTCGTGTGACTTTTGAGTATATTATGCTCAATGGTGTTAATGATAGCCCTGAAAATGCTCAGGAATTGGCAGATTTGACTAAGAAAATCCGCAAACTTTCCTATGTTAATTTAATTCCGTACAATCCTGTCACGGAACACGACCAGTACAGTCGTAGCCCCAAAGAGCGTGTAGATGCTTTTTACGATGTTCTTAAGAAAAATGGTGTTAACTGTGTGGTGCGTCAGGAACATGGAACTGATATTGATGCAGCCTGTGGACAGCTGCGTTCTAATACTATGAAACGCGATCGTGAGAAAGCGACTGCCGGAACAGCTCAGTAA","7.70","2.66","41139","MKPSIYSLTRNDLIAWTIEHGEKKFRATQIWDWLYRKRVQSFEEMTNLSKDFIALLNENFLVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQHYGLSVCVTTQVGCNIGCTFCASGLIKKQRDLNNGEITAQIMLVQKYFDERGQGERISHVVVMGIGEPFDNYDNVLKFLRTINDDNGLAIGARHITVSTSGLAHKIRDFANEGVQVNLAVSLHAPNNELRSSIMRINRSFPLEKLFAAIEYYIETTNRRVTFEYIMLNGVNDSPENAQELADLTKKIRKLSYVNLIPYNPVTEHDQYSRSPKERVDAFYDVLKKNGVNCVVRQEHGTDIDAACGQLRSNTMKRDREKATAGTAQ","489711","","conserved hypothetical protein","Cytoplasm","Numerous matches in gapped BLAST to conserved hypothetical proteins. Residues 1-357 are 89% similar to gi|15675432 from S.pyogenes and 86% similar to gi|15900662 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0458 (0.0).","

InterPro
IPR004383
Family

Conserved hypothetical protein 48
TIGR00048	$\"[1-357]T$	CHP48

InterPro
IPR006638
Domain

Elongator protein 3/MiaB/NifB
SM00729	$\"[101-317]T$	Elp3

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[105-278]T$	Radical_SAM

noIPR
unintegrated

unintegrated
SSF102114	$\"[98-321]T$	SSF102114

","BeTs to 8 clades of COG0820COG name: Predicted Fe-S-cluster redox enzymeFunctional Class:� RThe phylogenetic pattern of COG0820 is -----QVcebRhuj---l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 157-284 are 28% similar to a (COMPLETE PROTEOME COFACTOR BIOSYNTHESIS MOLYBDENUM) protein domain (PD000790) which is seen in O67488_AQUAE.Residues 3-66 are 57% similar to a (PROTEOME COMPLETE BH2506 UU214) protein domain (PD306250) which is seen in Q9K9Y8_BACHD.Residues 157-345 are 75% similar to a (COMPLETE PROTEOME YBID BH2506) protein domain (PD007453) which is seen in Q9CJ27_LACLA.Residues 8-58 are 78% similar to a (COMPLETE PROTEOME YBID XF0459) protein domain (PD328406) which is seen in Q9CJ27_LACLA.Residues 74-142 are 81% similar to a (COMPLETE PROTEOME YBID BH2506) protein domain (PD006794) which is seen in Q9CJ27_LACLA.Residues 1-96 are 41% similar to a (JHP1325 HP1428) protein domain (PD336815) which is seen in YE28_HELPJ.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Feb 24 14:00:05 2002","Sun Feb 24 14:00:05 2002","Sun Feb 24 14:00:05 2002","Sun Feb 24 14:00:05 2002","","Sun Feb 24 14:00:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0473 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 14:00:05 2002","","No significant hits to the NCBI PDB database.","SMU.522","","Residues 105 to 278 (E-value = 2.5e-17) place SMu0473 in the Radical_SAM family which is described as Radical SAM superfamily (PF04055)","Sun Feb 24 14:00:05 2002","24379004","","","","","","1","","","SMU.522","55" "SMu0474","489714","490250","537","ATGACTGCTTTTTTTGATGAAACAGCTGAGTTAAAACCAATCGGCCGCAAGTTATCTTGGCTTTTGCTGGTTTTATATTTTATCGCTATTTGCTATATGTGTTTTTGTCCTCAGCATACAATAAGGGGTGTTCAAACCCCGAACATTCAGCATTTTGGTCGGCTTGTTATACTGCCTGTGCCTTTCAATTCACTATTTAGTTTAGGGCACTTGTCCAATCTTTTGAAACTTATCTGGGTGTTTGGTCAAAATGTTGTTAATATCTTTTTGCTTTTTCCCTTGGTTTTGCAAGTTCTGTTACTCTTTCCAAACTTGAGAAATAAGAAAAAAATCTTGTTATTTAGTTTTTGTCTAAGTCTAAGTATTGAATGCACACAACTGCTTCTTGATTTCTTTTTTGATGTTAATCGTGTTTTTGAAATTGATGATTTATGGACCAATAGTTTAGGTGGTTTATTAGCCTTTTATTGTCACCTTTTTATTCAAAAGAAAATAAGAGCATATTATCAACAGAAATCTCAAAGTGGTAAGGCTTGA","9.40","7.66","20671","MTAFFDETAELKPIGRKLSWLLLVLYFIAICYMCFCPQHTIRGVQTPNIQHFGRLVILPVPFNSLFSLGHLSNLLKLIWVFGQNVVNIFLLFPLVLQVLLLFPNLRNKKKILLFSFCLSLSIECTQLLLDFFFDVNRVFEIDDLWTNSLGGLLAFYCHLFIQKKIRAYYQQKSQSGKA","490247","","conserved hypothetical protein, VanZ-like family","Membrane, Cytoplasm","Limited hits in gapped BLAST to S.pneumoniae sequences. Residues 27-166 are 45% similar to gi15900663; residues 23-166 are 43% similar to gi15902721.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0459 (5e-33).","

InterPro
IPR006976
Family

VanZ like protein
PF04892	$\"[17-167]T$	VanZ

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[24-297]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[478-520]T$	ABC_transporter
PF00005	$\"[367-551]T$	ABC_tran
PS00211	$\"[478-492]T$	ABC_TRANSPORTER_1
PS50893	$\"[341-575]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[366-552]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[25-309]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[304-573]T$	G3DSA:3.40.50.300
PTHR19242	$\"[4-587]T$	PTHR19242
PTHR19242:SF86	$\"[4-587]T$	PTHR19242:SF86
SSF52540	$\"[342-580]T$	SSF52540
SSF90123	$\"[1-330]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 9.5e-56. IPB001140A 356-402 IPB001140B 475-513 IPB001140C 528-557 IPB001140A 270-316","Residues 1-345 are 21% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD320911) which is seen in Q9X151_THEMA.Residues 1-323 are 21% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD321047) which is seen in Q9X136_THEMA.Residues 413-475 are 40% similar to a (TRANSPORT ATP-BINDING ABC TRANSPORTER) protein domain (PD306522) which is seen in Q48868_LACSK.Residues 10-321 are 21% similar to a (ATP-BINDING COMPONENT ABC TRANSPORT) protein domain (PD321417) which is seen in Q9L2K4_STRCO.Residues 417-472 are 42% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD265501) which is seen in Q9HWN8_PSEAE.Residues 175-322 are 25% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD168310) which is seen in O67511_AQUAE.Residues 162-273 are 48% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD200980) which is seen in O07550_BACSU.Residues 419-536 are 28% similar to a (PROTEOME COMPLETE MULTIDRUG RESISTANCE) protein domain (PD088230) which is seen in Q48851_LACSK.Residues 166-344 are 24% similar to a (ATP-BINDING TRANSPORT MG014 TRANSMEMBRANE) protein domain (PD033674) which is seen in Y014_MYCPN.Residues 155-256 are 43% similar to a (ATP-BINDING ABC PROTEOME TRANSPORTER) protein domain (PD260448) which is seen in Q9CG37_LACLA.Residues 524-587 are 40% similar to a (ATP-BINDING MDLA MULTIDRUG) protein domain (PD389420) which is seen in MDLA_BUCAI.Residues 13-335 are 18% similar to a (PROTEOME ATP-BINDING COMPLETE ABC) protein domain (PD138429) which is seen in P72613_SYNY3.Residues 412-475 are 45% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760) which is seen in Q9PE08_XYLFA.Residues 98-334 are 24% similar to a (ATP-BINDING TRANSPORT ABC COMPLETE) protein domain (PD009694) which is seen in Q9EWN8_STRCO.Residues 33-133 are 48% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348) which is seen in Q9KAF1_BACHD.Residues 278-351 are 44% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in Q9CG37_LACLA.Residues 69-231 are 24% similar to a (ATP-BINDING PROTEOME PM1473 COMPLETE) protein domain (PD087458) which is seen in Y664_HAEIN.Residues 411-476 are 37% similar to a (PROTEOME ATP-BINDING FUSION COMPLETE) protein domain (PD268678) which is seen in Q9I4M2_PSEAE.Residues 357-408 are 44% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9KEB2_BACHD.Residues 478-520 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O07550_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 16:08:16 2002","Tue Jul 25 11:05:41 2006","Tue Jul 25 11:05:41 2006","Fri Apr 26 08:43:37 2002","Sun Feb 24 14:06:28 2002","Sun Feb 24 14:06:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0475 is paralogously related (blast p-value < 1e-3) to SMu0825, SMu0986, SMu0476, SMu0824, SMu0837, SMu1065, SMu0836, SMu1064, SMu0258, SMu1710, SMu1724, SMu0987, SMu0024, SMu0916, SMu1950, SMu1288, SMu1920, SMu0235, SMu1003, SMu0218, SMu1380, SMu0971, SMu0517, SMu0418, SMu0390, SMu0786, SMu0950, SMu0731, SMu0752, SMu1037, SMu1036, SMu0216, SMu0335, SMu1751, SMu1757, SMu1517, SMu0884, SMu0234, SMu1949, SMu0805, SMu1001, SMu1762, SMu1068, SMu1316, SMu1246, SMu1231, SMu1210, SMu0594, SMu1079, SMu0907, SMu0849, SMu1545, SMu0944, SMu0976, SMu1410, SMu1518, SMu1428, SMu1023, SMu1649, SMu1093, SMu0164, SMu0374, SMu0729, SMu0224, SMu0596, SMu1811, SMu0823, SMu1306, SMu1959, SMu0666, and SMu1050, all ATP-binding proteins.","Fri Apr 26 08:43:37 2002","Tue Jul 25 11:05:41 2006","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 64 6e-011","SMU.524","","Residues 24 to 297 (E-value = 2.3e-44) place SMu0475 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 367 to 551 (E-value = 8.9e-52) place SMu0475 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jul 25 11:05:41 2006","24379006","","","","Mon Oct 28 16:05:34 2002","","1","","","SMU.524","56" "SMu0476","492142","493884","1743","ATGAAGAATAATGAACACCAAGGCCATGTTTTTTGGCGTCTGATGTCTTATCTTAAGCCCTATAAATGGTTGACTTTCTTCGCCTTGCTTTTCCTTTTGTCAACAACAGTGATTAAAAGTTTCGTCCCCTTAGTGGCCTCTTATTTTATTGATCATTTTTTGACTCATTTCAATCAGACAGCAGCTTCACTTTTGCTGGGCTACTACTTGCTCTATGTTTTGCAGACGATTTTACAATATTTTGGCAATCTTCTTTTTGCGCGTGTTTCTTTTAGTGTTGTTCGCGACATTCGTAGGGATGCCTTTGCCAATATGGAAAGATTGGGAATGGCCTATTTCGATAAAACGCCAGCAGGTTCGATTGTATCGCGCTTAACCAATGATACAGAAAGTATTAGTGACATGTTTTCAGGCATCTTATCTAGTTTTATTTCAGCTATTTTTATTTTTAGTGTTACCCTTTATACCATGTTAATGCTGAATTATCGCCTAACCTTTCTTGTCATGCTTTTTTTGCCTTTTATTTTTATTTTGGTCAATCTCTATCGTAAAAAGTCTGTTAAGGTTATTGCTAAAACGAGGAGTTTATTGAGTGATATCAATACCAATTTATCTGAAAGTATTGGAGGTATCAATATTATTCAAGCTTTTGGACAAGAAGAGCGTTTAAAAGCAGAATTTGAGGCAATCAATGAAGAACATTTTCATTATGCCAATCGTTCTATGGCCTTGGACAGTCTTTTCCTACGTCCAGCTATGTCGCTTTTGAAGCTTTTGGCTTATGCTCTTTTGATGGCTTATTTTGGATTTAATTGGCAGACTATTGGTATTTCAGCTGGGATGATGTATGCCTTTATTCAATATGTTAATCGCCTCTTTGACCCTTTAATTGAAGTGACTCAGAATTTCTCAACCTTGCAAACTTCTATGGTCTCAGCTGGACGTGTTTTTGATCTGATAGATGAAAGGGATTATGAACCACATCAAGATGATAGTGACATTAGCATTTCAGCTGGTAATATTGAATTTAGGGATGTTTCTTTCTCATATGATGGTCAGCATCAAATTTTAGATCATATTTCTTTTAAAGTCAATCAAGGTCAAACGATTGCTTTTGTTGGTCCAACAGGGTCAGGCAAGTCTTCTATTATTAATGTTTTCATGCGCTTTTATGAATTTCAAAAAGGTCAAGTTACCATTGATGGACATGATATCCGTAACTATAGCCAAGAAGAATTACGCAAAAATGTTGGTCTGGTTTTGCAAGAGCCCTTCCTTTATCATGGGACAATCAAGTCTAATATAAAAATGTATCAGGATTTGACAGATGCGGATATTGAAGCTGCGGCAAAATTTGTGGATGCTGATCAATTTATTCAAAAATTGGCTCATAAATATGAGGAACCTGTTAGTGAAGGTGGTTCAAGTTTTTCAACTGGTCAGCGTCAGCTAATGGCTTTTGCCAGAACGGTAGCAAGTTCGCCTAAAATTTTAATTCTTGATGAAGCGACAGCTAATATTGACTCAGAAACAGAACAATTGGTTCAAAATTCTTTGGCTAAAATGCGTAGAGGACGGACAACCATTGCGATTGCCCATCGTTTATCAACCATTCAAGATGCCAACTGTATTTATGTTCTTGATAAGGGTAAAATTATTGAGTCGGGAACTCATGAGGAACTTCTAGCGAAAAAAGGAACCTATCACAAAATGTATCAACTCCAAGCAGGTATGATGGATTGA","6.80","-1.40","66072","MKNNEHQGHVFWRLMSYLKPYKWLTFFALLFLLSTTVIKSFVPLVASYFIDHFLTHFNQTAASLLLGYYLLYVLQTILQYFGNLLFARVSFSVVRDIRRDAFANMERLGMAYFDKTPAGSIVSRLTNDTESISDMFSGILSSFISAIFIFSVTLYTMLMLNYRLTFLVMLFLPFIFILVNLYRKKSVKVIAKTRSLLSDINTNLSESIGGINIIQAFGQEERLKAEFEAINEEHFHYANRSMALDSLFLRPAMSLLKLLAYALLMAYFGFNWQTIGISAGMMYAFIQYVNRLFDPLIEVTQNFSTLQTSMVSAGRVFDLIDERDYEPHQDDSDISISAGNIEFRDVSFSYDGQHQILDHISFKVNQGQTIAFVGPTGSGKSSIINVFMRFYEFQKGQVTIDGHDIRNYSQEELRKNVGLVLQEPFLYHGTIKSNIKMYQDLTDADIEAAAKFVDADQFIQKLAHKYEEPVSEGGSSFSTGQRQLMAFARTVASSPKILILDEATANIDSETEQLVQNSLAKMRRGRTTIAIAHRLSTIQDANCIYVLDKGKIIESGTHEELLAKKGTYHKMYQLQAGMMD","493881","For other components see SMu0476 (NBD1); SMu0475 (NBD2) and SMu0475 (MSD2).","ABC transporter ATP-binding / permease protein","Membrane, Cytoplasm","Matches in gapped BLAST to ABC transporter ATP-binding/membrane spanning proteins. Residues 1-579 are 68% similar to gi15903698 from S.pneumoniae. Residues 3-577 are 44% similar to gi15614898 from B.halodurans.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0461 (0.0).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[25-296]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[477-519]T$	ABC_transporter
PF00005	$\"[367-550]T$	ABC_tran
PS50893	$\"[341-574]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[366-557]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[26-308]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[306-572]T$	G3DSA:3.40.50.300
PTHR19242	$\"[2-575]T$	PTHR19242
PTHR19242:SF91	$\"[2-575]T$	PTHR19242:SF91
SSF52540	$\"[341-579]T$	SSF52540
SSF90123	$\"[1-327]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5e-62. IPB001140A 356-402 IPB001140B 474-512 IPB001140C 527-556","Residues 524-554 are 77% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383) which is seen in O43121_ASPFU.Residues 169-239 are 39% similar to a (ATP-BINDING TRANSPORT TRANSMEMBRANE GLYCOPROTEIN) protein domain (PD001096) which is seen in O07549_BACSU.Residues 523-580 are 40% similar to a (TRANSPORT HOMOLOG ATP-BINDING DRUG) protein domain (PD084250) which is seen in STE6_YEAST.Residues 160-270 are 24% similar to a (ATP-BINDING MULTIDRUG RESISTANCE-LIKE) protein domain (PD252317) which is seen in MDLB_ECOLI.Residues 157-251 are 46% similar to a (ATP-BINDING ABC PROTEOME TRANSPORTER) protein domain (PD260448) which is seen in Q9KAF2_BACHD.Residues 527-577 are 45% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD394504) which is seen in Q9ZIC8_LISMO.Residues 280-350 are 38% similar to a (ATP-BINDING TRANSPORT TRANSPORTER PEPTIDE) protein domain (PD168165) which is seen in Q9CC89_MYCLE.Residues 409-474 are 31% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760) which is seen in P73278_SYNY3.Residues 77-135 are 49% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348) which is seen in Q9KAF2_BACHD.Residues 277-356 are 41% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in Q9KAF2_BACHD.Residues 409-476 are 47% similar to a (ABC PROTEOME BINDING COMPLETE) protein domain (PD387933) which is seen in Q9CG38_LACLA.Residues 277-356 are 32% similar to a (ABC PROTEOME BINDING COMPLETE) protein domain (PD397376) which is seen in Q9CG38_LACLA.Residues 357-408 are 75% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CG38_LACLA.Residues 477-516 are 70% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CG38_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 10:33:56 2002","Tue Jul 25 11:10:08 2006","Tue Jul 25 11:10:08 2006","Fri Apr 26 08:42:52 2002","Sun Feb 24 14:11:04 2002","Sun Feb 24 14:11:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0476 is paralogously related (blast p-value < 1e-3) to SMu0825, SMu0986, SMu0837, SMu0824, SMu0475, SMu0258, SMu0836, SMu1710, SMu1065, SMu0987, SMu1064, SMu1724, SMu1950, SMu0235, SMu1380, SMu0390, SMu0731, SMu1920, SMu0418, SMu0335, SMu0024, SMu1246, SMu1231, SMu0971, SMu0849, SMu1949, SMu0517, SMu1762, SMu1068, SMu1003, SMu1517, SMu1757, SMu1410, SMu1210, SMu0916, SMu0884, SMu0596, SMu1036, SMu0218, SMu0786, SMu1545, SMu1023, SMu1316, SMu1288, SMu0805, SMu1037, SMu1079, SMu0907, SMu1518, SMu1428, SMu0374, SMu0234, SMu0752, SMu0216, SMu0944, SMu1649, SMu0224, SMu0950, SMu1001, SMu1751, SMu0594, SMu0164, SMu0976, SMu1306, SMu1959, SMu1050, SMu1093, SMu1811, SMu1725, SMu0729, SMu0823, SMu1202, and SMu0666, all ABC-related proteins.","Fri Apr 26 08:42:52 2002","Tue Jul 25 11:10:08 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 68 4e-012pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 67 5e-012","SMU.525","","Residues 25 to 296 (E-value = 4.5e-33) place SMu0476 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 367 to 550 (E-value = 2.6e-52) place SMu0476 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jul 25 11:10:08 2006","24379007","","","","Mon Oct 28 10:33:56 2002","","1","","","SMU.525","57" "SMu0477","494787","493951","837","ATGGAGTTTATTTTAAAAATTGGAGATTTTTCCTACATTAATAACATCCCTATTCAAACTCTGCGTTATTATGATAAAATTGGTCTTTTAAAACCCTATCGCATTGATCAAAAGACGAATTATCGTTATTATCATATCAATCAATCTCAGATAGTAGACGAAATCCAATATTTAAGACAGCTTGACTTTTCTCTGGAGGAAATTAAAGGAATACTTTCTAAACATGAAAATTTGACTGAACTCAACCATTACATTAATGAACGACGCCAGTGTCTTTTATTTGAAAAGCAACGTTTGGAAGAGCGCTTAGCAGAAATTAATACCTATCAAGCAGGTGCCTTTATGTATGATTATAAAAAGCATAACCAAGGTTTGGAAATTTTGACTTTACCAGCTAGACGAATGATTATTTATGAAACTAAAGAAAATATTTATCAAATGACTGATGAAGCTTATGAATTTAATCTAAGAAAATTTAAACAAGCTTTGAGAAAAAATAATCTCTCTTATTCAACCTTTTCTCGTGTTGGTTCTATTATTGAGAAAGAAGATTTCAAAAATAAAAATTGGTTATCTCATCAAATGTTTATGTTCTTTAATGATATTGTGGAAAAGTTTAAAATAAAGACCTACCCTTCTGCCCTTTATGCTTCAATTTATTGTTCCTCTTTTCAAGAGGAGATTGAAAAATTAGACGATTTCTATCAAATGATTGTTGATAAAGGTTATCAAATTAAGGGAGATTACATTTGCGAGGTCATTTATGAACATCCTAATTTAAATCACAACAAAAGAGAAATATTTATTAGAATGCAGGTCGCTGTTAATAAAGGCTAA","8.00","2.56","33706","MEFILKIGDFSYINNIPIQTLRYYDKIGLLKPYRIDQKTNYRYYHINQSQIVDEIQYLRQLDFSLEEIKGILSKHENLTELNHYINERRQCLLFEKQRLEERLAEINTYQAGAFMYDYKKHNQGLEILTLPARRMIIYETKENIYQMTDEAYEFNLRKFKQALRKNNLSYSTFSRVGSIIEKEDFKNKNWLSHQMFMFFNDIVEKFKIKTYPSALYASIYCSSFQEEIEKLDDFYQMIVDKGYQIKGDYICEVIYEHPNLNHNKREIFIRMQVAVNKG","493954","","transcriptional regulator","Cytoplasm","Weak similarities in gapped BLAST to transcriptional regulators. Residues 7-275 are 26% similar to gi|15616058 from B.halodurans. Residues 1-250 are 25% similar to gi|16077613 from B.subtilis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1655 (7e-12).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PF00376	$\"[6-43]T$	MerR
SM00422	$\"[5-75]T$	HTH_MERR
PS50937	$\"[1-74]T$	HTH_MERR_2

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[5-111]T$	Putativ_DNA_bind

InterPro
IPR011256
Domain

Bacterial regulatory factor, effector
SSF55136	$\"[121-276]T$	Bac_reg_effector

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[3-109]T$	G3DSA:1.10.1660.10

InterPro
IPR000846
Family

Dihydrodipicolinate reductase
PF01113	$\"[6-138]T$	DapB_N

noIPR
unintegrated

unintegrated
SSF51735	$\"[4-163]T$	SSF51735

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 8-196 are 26% similar to a (PROTEOME COMPLETE) protein domain (PD129996) which is seen in O29621_ARCFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Feb 24 14:20:06 2002","Sun Feb 24 14:20:06 2002","Sun Feb 24 14:20:06 2002","Sun Feb 24 14:20:06 2002","","Sun Feb 24 14:20:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0478 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 14:20:06 2002","","No significant hits to the NCBI PDB database.","SMU.527","","No significant hits to the Pfam 11.0 database","Sun Feb 24 14:20:06 2002","24379009","","","","","","1","","","SMU.527","" "SMu0479","496538","496257","282","ATGAAAATAATTAATGCAAGCTTTTTTATTAAGGCAGACAAAAGAGAAGAGTTTTTAGCCGACACCCTGCCCTTAATTCGTTCATCAAGAGCAGAATCCGGCAACATCAGCTATCAACTCTATGAAGCAATTGATACTCCTAATCAATTTGTGATGGTTGAAGAATGGCAAGATCAAACTGCCATCGATCAGCATAATAGTAACCCTTTATTGATTCAATTGCTGGAGAACTTAAAAATGTACAGCTCAGCCGAACCCATTATTAAAGTGACAGAAGGCTAG","4.40","-5.77","10645","MKIINASFFIKADKREEFLADTLPLIRSSRAESGNISYQLYEAIDTPNQFVMVEEWQDQTAIDQHNSNPLLIQLLENLKMYSSAEPIIKVTEG","496260","","conserved hypothetical protein","Cytoplasm","Weak similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-92 are 44% similar to gi|15672567 from L.lactis. Residues 1-66 are 43% similar to gi|16077455 from B.subtilis.SMu0479 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007138
Domain

Antibiotic biosynthesis monooxygenase
PF03992	$\"[10-73]T$	ABM

InterPro
IPR011008
Domain

Dimeric alpha-beta barrel
SSF54909	$\"[1-91]T$	Dimer_A_B_barrel

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.900	$\"[2-79]T$	G3DSA:3.30.70.900

","BeTs to 3 clades of COG1359COG name: Uncharacterized ACR, YneC familyFunctional Class:� SThe phylogenetic pattern of COG1359 is -------cEbR----------Number of proteins in this genome belonging to this COG is 1","***** IPB003771 (DUF176) with a combined E-value of 2.6e-13. IPB003771A 8-42 IPB003771B 50-85","Residues 3-90 are 44% similar to a (PROTEOME COMPLETE YFHK VCA0636) protein domain (PD020128) which is seen in Q9CHY3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Feb 24 14:22:39 2002","Sun Feb 24 14:22:39 2002","Sun Feb 24 14:22:39 2002","Sun Feb 24 14:22:39 2002","Sun Feb 24 14:22:39 2002","Sun Feb 24 14:22:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0479 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 14:22:39 2002","","No significant hits to the NCBI PDB database.","SMU.528c","","Residues 10 to 73 (E-value = 5e-16) place SMu0479 in the ABM family which is described as Antibiotic biosynthesis monooxygenase (PF03992)","Sun Feb 24 14:22:39 2002","24379010","","","","","","1","","","SMU.528c","" "SMu0480","496432","496545","114","ATGTTGCCGGATTCTGCTCTTGATGAACGAATTAAGGGCAGGGTGTCGGCTAAAAACTCTTCTCTTTTGTCTGCCTTAATAAAAAAGCTTGCATTAATTATTTTCATTGGTTAG","10.80","2.98","3965","MLPDSALDERIKGRVSAKNSSLLSALIKKLALIIFIG","496542","","hypothetical protein","Extracellular, Cytoplasm","No significant hits in gapped BLAST.SMu0480 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Feb 24 15:29:40 2002","Sun Feb 24 15:29:40 2002","Sun Feb 24 15:29:40 2002","Sun Feb 24 15:29:40 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0480 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 15:29:40 2002","","No significant hits to the NCBI PDB database.","SMU.529","","No significant hits to the Pfam 11.0 database","Sun Feb 24 15:29:40 2002","24379011","","","","","","1","","","SMU.529","" "SMu0481","497462","496725","738","ATGTCAAAAACAAGAGCTGAGCTAAAAGCAGAAGCTAAAGCACATCTGCAAGAAAACTGGGGTTACGCCATTGGCTTATATATTTTGCCGGTTTTAGCTGTTATGGGTATCTACTTGGCTTGCATCCTTGTATATGCTACTCTGACTGCCCCTCTTGCCCTATCTATAGGGGAAACTGCTTTTCTTGCAACATTACCACTTCTCATTATTCTGTGGTTACTAGTTTTGGTAGTTTCATCCACGGTGACAATCGGAGTTAATTTAGGATTTCTGAACTTCTTTAGAGGAGGACGTCCAACTTATACTGAAGCGAGTACCTATCTTTTAAAAGAAAACCGCTTTTGGAAGTTCCTCTGGACCAATGTGCTTATGGTCATTTTGCTTTACCTATGGTCATTGCTCTTTCTTATCCCTGGAATCATTAAAACTTACAGTTACTCCATGACCAACTATATTCTTAAAGACAAATTGGAAAAAGGCGAATCAGTAACTGTCACTCAGGCTATTACTGAAAGCCGTCAATTAATGAACGGTCATAAATGGGAATACTTTGTCCTTCAGTTAAGCTTTATTGGCTGGGCCATTTTAGCCAATCTTACCTTTGGTATTGGCTATCTTTGGCTCGTCCCTTACATTGAAACAACCAATGCTGCCTTTTATCAAAATTTGATTGACAGTCAAATAGCAAATCATTCTATTGTATCTCTATCTCAAGAAATTGAAACAGGAACTGTCTAA","7.60","0.67","27624","MSKTRAELKAEAKAHLQENWGYAIGLYILPVLAVMGIYLACILVYATLTAPLALSIGETAFLATLPLLIILWLLVLVVSSTVTIGVNLGFLNFFRGGRPTYTEASTYLLKENRFWKFLWTNVLMVILLYLWSLLFLIPGIIKTYSYSMTNYILKDKLEKGESVTVTQAITESRQLMNGHKWEYFVLQLSFIGWAILANLTFGIGYLWLVPYIETTNAAFYQNLIDSQIANHSIVSLSQEIETGTV","496728","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches to fragments of hypothetical proteins in gapped BLAST. Residues 90-227 are 43% similar to gi|322156 from B.megatherium. Residues 140-223 are 40% similar to gi|15674402 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0395 (4e-15).","

InterPro
IPR010380
Family

Protein of unknown function DUF975
PF06161	$\"[1-227]T$	DUF975

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 90-223 are 43% similar to a (PROTEOME 5'REGION P450MEG COMPLETE) protein domain (PD114897) which is seen in Q06073_BACME.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Feb 24 15:33:04 2002","Sun Feb 24 15:33:04 2002","Sun Feb 24 15:33:04 2002","Sun Feb 24 15:33:04 2002","","Sun Feb 24 15:33:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0481 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 15:33:04 2002","","No significant hits to the NCBI PDB database.","SMU.530c","","Residues 1 to 227 (E-value = 4.8e-114) place SMu0481 in the DUF975 family which is described as Protein of unknown function (DUF975) (PF06161)","Sun Feb 24 15:33:04 2002","24379012","","","","","","1","","","SMU.530c","" "SMu0482","498134","498445","312","ATGCAGGTGATAATTATGACAAGTATCCAGAATCTGAGAAATCAAATTGATCAGTTAGATCATCAATTATTAGTTCTATTAGCGCAACGTCAGCAAATTGTTGAAAAGATTGGTCAGCTAAAACCTATCAACAGTCAAGCAGCTGTCACTGCTCCTGATCGAGTGAAACAAGTCCTTTTAAATAGACAGCAAGAGGCAGAAAAGCTCGGTCTATCACCAGATGTTGCTCTGGCTATTTGGCAAACGATGATTGAGGCTTTCACAGCTTTAGAGCTAAAGATTAATAGCAATCATGACCTAAATAGAAAGTGA","9.30","1.47","11687","MQVIIMTSIQNLRNQIDQLDHQLLVLLAQRQQIVEKIGQLKPINSQAAVTAPDRVKQVLLNRQQEAEKLGLSPDVALAIWQTMIEAFTALELKINSNHDLNRK","498442","","chorismate mutase; possible prephenate dehydrogenase","Cytoplasm","This sequence corresponds to gi:24379013 in Genbank.Its nearest neighbor in the NR database is gi:28897321 from Vibrio parahaemolyticus RIMD 2210633.SMu0482 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002701
Domain

Chorismate mutase
PF01817	$\"[13-94]T$	CM_2
PS51168	$\"[3-95]T$	CHORISMATE_MUT_2
SSF48600	$\"[7-98]T$	Chorismate_mut

noIPR
unintegrated

unintegrated
G3DSA:1.20.59.10	$\"[9-82]T$	G3DSA:1.20.59.10

","BeTs to 5 clades of COG1605COG name: Chorismate mutaseFunctional Class: EThe phylogenetic pattern of COG1605 is amt--qv-EbrHuj-------Number of proteins in this genome belonging to this COG is 2","***** IPB002701 (Chorismate mutase) with a combined E-value of 1.4e-11. IPB002701 9-41","Residues 8-75 are 42% similar to a (CHORISMATE PROTEOME COMPLETE MUTASE) protein domain (PD005194) which is seen in Q9CMY6_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Feb 24 15:38:53 2002","Fri May 20 09:49:19 2005","Fri May 20 09:48:58 2005","Tue Oct 8 09:38:52 2002","Sun Feb 24 15:34:21 2002","Sun Feb 24 15:34:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0482 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 15:38:53 2002","","No significant hits to the NCBI PDB database.","SMU.531","","Residues 5 to 92 (E-value = 4.8e-06) place SMu0482 in the Chorismate_mut family which is described as Chorismate mutase (PF01817)","Sun Feb 24 15:34:21 2002","24379013","","","","","","1","","","SMU.531","" "SMu0483","498454","499815","1362","ATGAAAAAGAAGATATTGAGTGCTGATATTTTGACCCCAATCCTTGCTTACATGCGTGTACAGGGCGACCATAAGGTGATTTTGGAGTCTATCCCTCGTGAAAAGGAAAATGCGCGTTTTTCAATTGTTGCTTACAATCCTGTTTTTGAAATCAAATTTGAAAATGGGCAATTGACAGAGAATGACAAAGTTATTGAAAGTGATCCCTTAGATTATCTCAGTCAAATCACTGTCAAATCACAACTGTCTCAAGATTTACCTTTTAATGGTGGCGCTATTGGTTTTGTGGGCTATGACATGGTTGGTCTTTATGAAAATATTGGCAAGATTCCTCAAGATACGATTGGAACACCGGATATGCACTTTTTTGTTTATGAATCTTATCTTATTTTTGATCATAAGAAAGAAAAAATTGTCATTGTTGAAGATAATATTTACAGCGGCAGAGAAGAAGAGGAACAAAAGGCTGCCTTGCAGGAAGTCTTAGCAGATCTTAAAAAACAGGCGGTTGATGAATTTTCGGAACGCGATTTACACACTTTGACTTTTAGGAACCATTTGGAAGAAGCTACTTTTAAAGACATGGTTACCAAAGCAAAAAAATTTATTCGTCAGGGAGATATGTTTCAATGCGTGCTCAGCCAGCGTTTCTCAGCGGATATTAGTGGCAAGCCGCTAGATTTTTATCGTAATTTACGTATTACCAACCCTTCCAATTATCTTTACTTTTATGATTTTGGTGATTATCAGATTATTGGAGCCAGTCCAGAAAGTCTCGTTTCTCTTAAAAATGGTGTGGTTACTACAAATCCTATTGCAGGAACACGTCCTCGTGGTGCCAACGATCAGAAAGACAAAGACTTATCTGAAGAGCTCTTATCAGATGTCAAGGAAGTAGCAGAGCACCGTATGTTGGTAGATTTGGGCCGCAACGATATTGGGAAAATTGCTGAGGTAGGAAGTGTTCAAGTTACCAAGTATATGGAAGTCGAATTTTTTCGCTATGTTATGCATTTAACTAGTGTTGTCAAGGGTAAACTTCTGTCAGGTTTGACTGGTATGGATGCTCTTAAGTCAACATTGCCAGCGGGTACGGTATCAGGAGCACCGAAAATTCGTGCTATGAAGCGCATTTATGAGTTGGAAAAAGAAAAGCGCGGTATCTATGCAGGAGCAATTGGTTATCTGTCAGCAAGCGGAGATATGGACTTTGCCATTGCCATTCGTACCATGATTATCAAAAATCAAAAGGCTTATGTTCAAGCAGGTGCGGGGATTGTCTATGATAGCGTTCCTGAAAATGAATACTACGAAACCATTAATAAGGCCAAAGCAATGACTAGAATAGGAGAGATACAGTGA","5.70","-6.31","51032","MKKKILSADILTPILAYMRVQGDHKVILESIPREKENARFSIVAYNPVFEIKFENGQLTENDKVIESDPLDYLSQITVKSQLSQDLPFNGGAIGFVGYDMVGLYENIGKIPQDTIGTPDMHFFVYESYLIFDHKKEKIVIVEDNIYSGREEEEQKAALQEVLADLKKQAVDEFSERDLHTLTFRNHLEEATFKDMVTKAKKFIRQGDMFQCVLSQRFSADISGKPLDFYRNLRITNPSNYLYFYDFGDYQIIGASPESLVSLKNGVVTTNPIAGTRPRGANDQKDKDLSEELLSDVKEVAEHRMLVDLGRNDIGKIAEVGSVQVTKYMEVEFFRYVMHLTSVVKGKLLSGLTGMDALKSTLPAGTVSGAPKIRAMKRIYELEKEKRGIYAGAIGYLSASGDMDFAIAIRTMIIKNQKAYVQAGAGIVYDSVPENEYYETINKAKAMTRIGEIQ","499812","For component II, see SMu0484.For other 'trp' genes see SMu0484 (trpG); SMu0485 (trpD); SMu0486 (trpC); SMu0487 (trpF); SMu0488 (trpB); SMu0489 (trpA).","anthranilate synthase, component I","Cytoplasm","Matches in gapped BLAST to anthranilate synthase component I sequences. Residues 3-453 are 72% similar to the enzyme from S.pneumoniae (gi|15903679). Residues 2-451 are 53% similar to gi|15673452 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1528 (1e-44).","

InterPro
IPR005256
Family

Anthranilate synthase component I
TIGR00564	$\"[8-451]T$	trpE_most

InterPro
IPR005801
Domain

Anthranilate synthase component I and chorismate binding protein
PD000779	$\"[85-441]T$	Anth_synth_chor
PR00095	$\"[290-303]T$ $\"[304-317]T$ $\"[384-398]T$ $\"[399-413]T$	ANTSNTHASEI
PF00425	$\"[188-450]T$	Chorismate_bind

InterPro
IPR006805
Domain

Anthranilate synthase component I, N-terminal
PF04715	$\"[2-140]T$	Anth_synt_I_N

noIPR
unintegrated

unintegrated
G3DSA:3.60.120.10	$\"[8-449]T$	G3DSA:3.60.120.10
PTHR11236	$\"[57-452]T$	PTHR11236
PTHR11236:SF9	$\"[57-452]T$	PTHR11236:SF9
SSF56322	$\"[4-449]T$	SSF56322

","BeTs to 11 clades of COG0147COG name: Anthranilate/para-aminobenzoate synthases component IIFunctional Class: E,HThe phylogenetic pattern of COG0147 is amt-YQvCEBRHUJ-------Number of proteins in this genome belonging to this COG is 1","***** PR00095 (Anthranilate synthase component I signature) with a combined E-value of 9e-29. PR00095A 290-303 PR00095B 304-317 PR00095C 384-398 PR00095D 399-413","Residues 192-446 are 61% similar to a (SYNTHASE ANTHRANILATE COMPONENT BIOSYNTHESIS LYASE) protein domain (PD000779) which is seen in TRPE_LACLA.Residues 27-151 are 32% similar to a (I ANTHRANILATE COMPONENT SYNTHASE) protein domain (PD127077) which is seen in TRPE_CLOTM.Residues 8-105 are 31% similar to a (SYNTHASE ANTHRANILATE COMPONENT LYASE) protein domain (PD176622) which is seen in Q9KCB4_BACHD.Residues 2-187 are 45% similar to a (I COMPONENT LYASE SYNTHASE) protein domain (PD204396) which is seen in TRPE_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:11:55 2002","Sun Feb 24 15:50:58 2002","Sun Feb 24 15:43:51 2002","Mon Apr 1 14:07:06 2002","Sun Feb 24 15:40:02 2002","Sun Feb 24 15:40:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0483 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 15:43:51 2002","Sun Feb 24 15:40:02 2002","pdb|1QDL|A Chain A, The Crystal Structure Of Anthranilate Synth... 280 2e-076","SMU.532","","Residues 2 to 140 (E-value = 6.4e-40) place SMu0483 in the Anth_synt_I_N family which is described as Anthranilate synthase component I, N terminal region (PF04715)Residues 188 to 450 (E-value = 7.6e-142) place SMu0483 in the Chorismate_bind family which is described as chorismate binding enzyme (PF00425)","Sun Feb 24 15:40:02 2002","24379014","","","Bardowski,J., Ehrlich,S.D. and Chopin,A.Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6563-6570 (1992)PubMed: 1400208","","Mon Apr 1 14:07:06 2002","1","","","SMU.532","" "SMu0484","499812","500375","564","GTGATTTTATTAATTGATAATTATGATTCTTTCACTTATAATTTGGCACAATTCATTGGTCATTTTACTGAAGTCAAGGTATTGAGAAATGATGATGCTGATCTTTATGAAGCAGCTCAAGAAGCAGATGGCCTTGTCTTTTCACCGGGCCCCGGTTGGCCAGCTGATGCTGGAAGGATGGAAGCCTTGATTAAAGACTTTACAGGGGAAAAACCTATTTTGGGAGTCTGCTTAGGACACCAAGCCATTGCTGAAAGTTTTGGAGGGAAATTGGGATTAGCTCATCAAGTCATGCACGGCAAGCAAAGTCAGATGGCAATCACAAAATCGTCGCCAATTTTTAAAGAATTAGCAGAAAAACTCGAAATCATGCGCTATCATTCTATAGTAGTCGATAAGCTACCAGAAAATTTTGAAGTAACGGCTAGAACAGTAGATGATGGCGAGATTATGGCTATTCAGCATAAGACGCTTCCAATCTATGGTTTACAATATCATCCAGAATCCATTGGCACACCTGAAGGATTAAAAATGATTGAGAATTTTGTAAGATTAGTCGGTTAG","5.00","-8.36","20672","MILLIDNYDSFTYNLAQFIGHFTEVKVLRNDDADLYEAAQEADGLVFSPGPGWPADAGRMEALIKDFTGEKPILGVCLGHQAIAESFGGKLGLAHQVMHGKQSQMAITKSSPIFKELAEKLEIMRYHSIVVDKLPENFEVTARTVDDGEIMAIQHKTLPIYGLQYHPESIGTPEGLKMIENFVRLVG","500372","For component I, see SMu0493.For other 'trp' genes see SMu0483 (trpE); SMu0485 (trpD); SMu0486 (trpC); SMu0487 (trpF); SMu0488 (trpB); SMu0489 (trpA). ","anthranilate synthase, component II","Cytoplasm","Matches in gapped BLAST to anthranilate synthase, component II sequences. Residues 1-186 are 67% similar to gi15901645 from S.pneumoniae and are 62% similar to gi15673451 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0462 (1e-57).","

InterPro
IPR000991
Domain

Glutamine amidotransferase class-I
PF00117	$\"[3-186]T$	GATase

InterPro
IPR001317
Domain

Carbamoyl-phosphate synthase, GATase region
PR00099	$\"[42-56]T$ $\"[72-88]T$	CPSGATASE

InterPro
IPR006220
Domain

Anthranilate synthase component II/delta crystallin
PR00097	$\"[2-16]T$ $\"[45-54]T$ $\"[72-83]T$ $\"[97-105]T$ $\"[118-130]T$ $\"[162-175]T$	ANTSNTHASEII

InterPro
IPR006221
Domain

Glutamine amidotransferase of anthranilate synthase
TIGR00566	$\"[1-185]T$	trpG_papA: glutamine amidotransferase of an

InterPro
IPR011702
Domain

Glutamine amidotransferase superfamily
PR00096	$\"[45-54]T$ $\"[72-83]T$ $\"[162-175]T$	GATASE

InterPro
IPR012998
Active_site

Glutamine amidotransferase, class I, active site
PS00442	$\"[72-83]T$	GATASE_TYPE_I

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.880	$\"[2-186]T$	no description
PIRSF001375	$\"[1-187]T$	GMP synthase/anthranilate synthase component II
PTHR11922	$\"[1-186]T$	GMP SYNTHASE-RELATED

","BeTs to 11 clades of COG0512COG name: Anthranilate/para-aminobenzoate synthases component IFunctional Class: E,HThe phylogenetic pattern of COG0512 is amt-YqvcEbrHuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001674 (GMP synthase C terminal domain) with a combined E-value of 1.3e-13. IPB001674B 72-81 IPB001674D 161-182***** IPB000991 (Glutamine amidotransferase class-I) with a combined E-value of 6.6e-12. IPB000991A 72-81 IPB000991B 160-170***** IPB002474 (Carbamoyl-phosphate synthase small chain) with a combined E-value of 5.8e-09. IPB002474E 43-54 IPB002474G 142-183","Residues 1-51 are 52% similar to a (SYNTHASE GLUTAMINE AMIDOTRANSFERASE) protein domain (PD002064) which is seen in TRPG_AZOBR.Residues 73-134 are 38% similar to a (TRPG) protein domain (PD391013) which is seen in Q9L7U7_HAEDU.Residues 151-185 are 65% similar to a (GLUTAMINE SYNTHASE AMIDOTRANSFERASE BIOSYNTHESIS GMP) protein domain (PD348302) which is seen in Q9RTJ6_DEIRA.Residues 3-54 are 49% similar to a (SYNTHASE GLUTAMINE BIOSYNTHESIS II) protein domain (PD233381) which is seen in Q9EWC1_STRGR.Residues 45-138 are 47% similar to a (GMP GLUTAMINE AMIDOTRANSFERASE) protein domain (PD004928) which is seen in Q9ZES1_BBBBB.Residues 52-175 are 38% similar to a (GLUTAMINE AMIDO- LYASE TRANSFERASE) protein domain (PD252438) which is seen in TRPG_BRELA.Residues 43-90 are 39% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE SMALL CHAIN) protein domain (PD105693) which is seen in Q9LVW7_ARATH.Residues 2-51 are 62% similar to a (GLUTAMINE SYNTHASE II COMPONENT) protein domain (PD346308) which is seen in TRPG_LACLA.Residues 2-67 are 40% similar to a (TRPG PROTEOME COMPONENT COMPLETE) protein domain (PD095731) which is seen in Q9RL76_STAAU.Residues 54-150 are 62% similar to a (SYNTHASE GLUTAMINE AMIDOTRANSFERASE ANTHRANILATE) protein domain (PD000306) which is seen in TRPG_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri May 20 08:18:56 2005","Fri May 20 08:18:56 2005","Fri May 20 08:18:56 2005","Mon Apr 1 14:08:57 2002","Sun Feb 24 15:51:48 2002","Sun Feb 24 15:51:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0484 is paralogously related (blast p-value < 1e-3) to SMu0974, a predicted GMP synthase, to SMu0783, a predicted carbamoyl phosphate synthetase,small subunit, and to SMu1158 and SMu0962, also predicted glutamin amidotransferases.","Sun Feb 24 16:00:51 2002","Fri May 20 08:18:56 2005","pdb1QDLB Chain B, The Crystal Structure Of Anthranilate Synth... 157 7e-040pdb1JDBF Chain F, Carbamoyl Phosphate Synthetase From Escheri... 62 4e-011","SMU.533","","Residues 3 to 186 (E-value = 8.2e-72) place SMu0484 in the GATase family which is described as Glutamine amidotransferase class-I (PF00117)","Sun Feb 24 15:51:48 2002","24379015","","","Bardowski,J., Ehrlich,S.D. and Chopin,A.Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6563-6570 (1992)PubMed: 1400208","","Mon Apr 1 14:08:57 2002","1","","","SMU.533","776" "SMu0485","500396","501403","1008","ATGAAAGACATTTTTGAAAAATTAGCTGCTCAAGAAAATTTAACAGAAGCTGAAATAACAGCAGTTGCTGAAAAAATTTTTAAAGGAGAATTGTCAGAAGCACAAATAGCAGCCTTCTTGATGGCTTTGAAAATCAAGGGGGAAACACCGGAAGAAATTTTAGGTCTCGTTAAAACGATTAAAAAAAATGCAGCTGTTATTCCTAGCCAAACAAGCGATGCTATGGATAATTGTGGTACAGGTGGTGATAAGTCCTTTTCTTTCAATATTTCAACGACTTGTAGCTTTGTCCTCGCTGCTGGTGGCATCCATATTGCTAAGCATGGTAATCGTTCTATTTCTTCAAAATCAGGTTCAGCCGATGTCCTTGAAGAATTGGGAATCAATGTTGTCCTAGCTCCTGAAAAATTGGCCCAAGTTCTAGATGAGACAGGTATTGTCTTTCTCTTTGCTCAAAAGATGCATCCAGCCATGCGTTATATTTCACCGGCTAGACAGGCCTTAGGTATTCCAACGGTCATGAATCTTATTGGGCCACTGACACACCCCATGGATTTGGAAACGCAGCTGTTAGGCCTTTATCAGGCGGACTTACAAGATGATTTAGCTCAAGTTCTTAAACTTCTTGGTCGCAAACGTGCAGTTATTATCACTGGACCAGATAATATGGATGAAGCAGCACTTTATGGTAAAAATCATTATACTCTGTTGGATAATGGTCAGATTTCACAAGGTAGTTTCACTTTTGAAGATTTTGACATGCCAAAAGTTACGCTTGAGGATATCAAGGGTGGTGATGCTAAAGAAAATGCTCAAATCCTTGTTAGTGTTCTCAAAAATGAACCTAGTCCTTATTTAGAGACAACGCTTTTAAATGCTGGTCTTGGTTTTTATGCTAATGGTAAGGTGGATTCGATTAAAGAAGGCATTGACCTAGCACGTGAAGTCATTGCATCAGGCAAGGCTTATGCTAAATTAAAGGCATTACAGGAGGCGCAAGTTGACTAA","4.80","-10.87","36012","MKDIFEKLAAQENLTEAEITAVAEKIFKGELSEAQIAAFLMALKIKGETPEEILGLVKTIKKNAAVIPSQTSDAMDNCGTGGDKSFSFNISTTCSFVLAAGGIHIAKHGNRSISSKSGSADVLEELGINVVLAPEKLAQVLDETGIVFLFAQKMHPAMRYISPARQALGIPTVMNLIGPLTHPMDLETQLLGLYQADLQDDLAQVLKLLGRKRAVIITGPDNMDEAALYGKNHYTLLDNGQISQGSFTFEDFDMPKVTLEDIKGGDAKENAQILVSVLKNEPSPYLETTLLNAGLGFYANGKVDSIKEGIDLAREVIASGKAYAKLKALQEAQVD","501400","For other 'trp' genes see SMu0483 (trpE); SMu0484 (trpG); SMu0486 (trpC); SMu0487 (trpF); SMu0488 (trpB); SMu0489 (trpA). ","phosphoribosyl anthranilate transferase","Cytoplasm","Matches in gapped BLAST to anthranilate phosphoribosyl transferases. Residues 1-333 are 65% similar to the enzyme from S.pneumoniae (gi|15901644). Residues 1-334 are 59% similar to gi|15673450 from L.lactis.SMu0485 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000312
Domain

Glycosyl transferase, family 3
PD001864	$\"[73-244]T$	Glyco_trans_3
G3DSA:1.20.970.10	$\"[1-65]T$	Glyco_trans_3
G3DSA:3.40.1030.10	$\"[69-335]T$	Glyco_trans_3
PF00591	$\"[71-323]T$	Glycos_transf_3
PF02885	$\"[1-65]T$	Glycos_trans_3N

InterPro
IPR005940
Domain

Anthranilate phosphoribosyl transferase
TIGR01245	$\"[5-332]T$	trpD

noIPR
unintegrated

unintegrated
PTHR11922	$\"[1-262]T$	PTHR11922
SSF47648	$\"[1-68]T$	SSF47648
SSF52418	$\"[69-332]T$	SSF52418

","BeTs to 11 clades of COG0547COG name: Anthranilate phosphoribosyltransferaseFunctional Class: EThe phylogenetic pattern of COG0547 is amt-yqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000312 (Glycosyl transferase family) with a combined E-value of 1.3e-40. IPB000312A 82-128 IPB000312B 151-193***** IPB000053 (Thymidine/pyrimidine-nucleoside phosphorylase) with a combined E-value of 1.8e-10. IPB000053A 4-32 IPB000053B 35-65 IPB000053D 96-126 IPB000053G 316-335","Residues 13-310 are 60% similar to a (ANTHRANILATE TRANSFERASE) protein domain (PD001864) which is seen in TRPD_LACLA.Residues 12-333 are 24% similar to a (PHOSPHORYLASE THYMIDINE PROTEOME COMPLETE) protein domain (PD005916) which is seen in O59251_PYRHO.Residues 223-322 are 39% similar to a (TRANSFERASE ANTHRANILATE) protein domain (PD040684) which is seen in Q9RL77_STAAU.Residues 1-217 are 38% similar to a (TRANSFERASE ANTHRANILATE BIOSYNTHESIS) protein domain (PD130241) which is seen in TRPD_SULSO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:12:33 2002","Sun Feb 24 16:02:01 2002","Sun Feb 24 16:08:33 2002","Mon Apr 1 14:09:41 2002","Sun Feb 24 16:02:01 2002","Sun Feb 24 16:02:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0485 is paralogously related (blast p-value < 1e-3) to SMu1027, a predicted pyrimidine-nucleoside phosphorylase.","Sun Feb 24 16:09:39 2002","","No significant hits to the NCBI PDB database.","SMU.534","","Residues 1 to 65 (E-value = 1.1e-21) place SMu0485 in the Glycos_trans_3N family which is described as Glycosyl transferase family, helical bundle domain (PF02885)Residues 71 to 323 (E-value = 1e-110) place SMu0485 in the Glycos_transf_3 family which is described as Glycosyl transferase family, a/b domain (PF00591)","Sun Feb 24 16:02:01 2002","24379016","","","Yakhnin H, Babiarz JE, Yakhnin AV, Babitzke P.Expression of the Bacillus subtilis trpEDCFBA operon is influenced by translational coupling and Rho termination factor.J Bacteriol. 2001 Oct;183(20):5918-26.PMID: 11566991Bardowski J, Ehrlich SD, Chopin A.Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis.J Bacteriol. 1992 Oct;174(20):6563-70.PMID: 1400208","","Sun Feb 24 16:08:33 2002","1","","","SMU.534","" "SMu0486","501396","502163","768","TTGACTAAAGAGTTTTTACCTACTATTTTAAAGCAAAAACAAGAAGAGCTAGCTAGTCTAATTATGGAAGAAGTCAAACCGCTTCGCTTAACCTATCGTCTCTTTGATTTTTTAAAAGAGCATCATGACCAGTTGCAGATTGTTGCTGAAGTTAAAAAAGCTAGTCCCAGTATGGGAGACATCAACTTAGATGTTGACATTGTCAAACAAGCCCAAATGTATGAAGCCGCTGGAGCTGCTATGATTTCTGTTTTGACAGATCAGGTTTTTTTCAAGGGAAATATTGATTTTTTGGCTGAGATATCTGGCAGTGTCAGTATTCCGACCTTGGCTAAAGATTTTATTATTGATGAGAAGCAGATTGTTCGTAGCCGTAATGCTGGTGCGACTGTTATTTTGCTCATTGTGGCCGCTTTACCAGAGAAGAGACTGAAGGAATTGTATGACTTTGCTGCAGGTTTAGGACTAGAAGTTTTAGTGGAGACCCATAATTTGTCTGAATTGGAAATAGCTCATCGTATTGGAGCACAGATTATCGGTGTCAATAATCGTAATCTTGTTACTTTTGAAGTAGATATCAATACCAGCTTGGAGTTATCTACCCATTTCCGAGATGATAAGGTTTATATTTCCGAATCAGGTATTTTTACGGGACAGGACAGTAAACTCGTCGCTCCTTACTTTAATGCTATTCTTGTAGGAACGGCTCTCATGCAGGCAGATAATGTCGCTGATAAAGTAAAGGAGTTGGCTATTGACAAAGGTTAA","4.80","-9.78","28228","MTKEFLPTILKQKQEELASLIMEEVKPLRLTYRLFDFLKEHHDQLQIVAEVKKASPSMGDINLDVDIVKQAQMYEAAGAAMISVLTDQVFFKGNIDFLAEISGSVSIPTLAKDFIIDEKQIVRSRNAGATVILLIVAALPEKRLKELYDFAAGLGLEVLVETHNLSELEIAHRIGAQIIGVNNRNLVTFEVDINTSLELSTHFRDDKVYISESGIFTGQDSKLVAPYFNAILVGTALMQADNVADKVKELAIDKG","502160","For other 'trp' genes see SMu0483 (trpE); SMu0484 (trpG); SMu0485 (trpD); SMu0487 (trpF); SMu0488 (trpB); SMu0489 (trpA).","indole-3-glycerol phosphate synthase","Cytoplasm","Similarities in gapped BLAST to indole-3-glycerol phosphate synthase sequences. Residues 1-255 are 70% similar to gi|15901643 from S.pneumoniae. Residues 4-254 are 61% similar to the enzyme from L.lactis (gi|15673449).SMu0486 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001468
Domain

Indole-3-glycerol phosphate synthase, central region
PD001511	$\"[47-192]T$	TRPC_STRMU_Q8DVF5;
PS00614	$\"[47-65]T$	IGPS

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[2-250]T$	no description

InterPro
IPR013798
Domain

Indole-3-glycerol phosphate synthase
PF00218	$\"[5-250]T$	IGPS

noIPR
unintegrated

unintegrated
PTHR22854	$\"[11-251]T$	TRYPTOPHAN BIOSYNTHESIS PROTEIN
PTHR22854:SF2	$\"[11-251]T$	INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE

","BeTs to 11 clades of COG0134COG name: Indole-3-glycerol phosphate synthaseFunctional Class: EThe phylogenetic pattern of COG0134 is amt-yqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001468 (Indole-3-glycerol phosphate synthase) with a combined E-value of 4.7e-44. IPB001468A 48-59 IPB001468B 82-93 IPB001468C 108-139 IPB001468D 178-191 IPB001468E 227-240","Residues 6-250 are 62% similar to a (SYNTHASE TRYPTOPHAN PHOSPHATE) protein domain (PD001511) which is seen in TRPC_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:12:51 2002","Sun Feb 24 16:14:21 2002","Sun Feb 24 16:14:21 2002","Mon Apr 1 14:10:37 2002","Sun Feb 24 16:11:38 2002","Sun Feb 24 16:11:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0486 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 16:14:21 2002","Thu Oct 10 15:12:51 2002","pdb|1A53| Complex Of Indole-3-Glycerolphosphate Synthase Fro... 129 5e-031pdb|1IGS| Indole-3-Glycerolphosphate Synthase From Sulfolobus... 129 5e-031pdb|1PII| N-(5'phosphoribosyl)anthranilate Isomerase (E.C.5.... 129 5e-031","SMU.535","","Residues 5 to 250 (E-value = 4e-109) place SMu0486 in the IGPS family which is described as Indole-3-glycerol phosphate synthase (PF00218)","Sun Feb 24 16:11:38 2002","24379017","","","Bardowski J, Ehrlich SD, Chopin A.Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis.J Bacteriol. 1992 Oct;174(20):6563-70.PMID: 1400208 ","","Sun Feb 24 16:17:54 2002","1","","","SMU.535","" "SMu0487","502150","502731","582","TTGACAAAGGTTAAAATTTGCGGTCTATCAACACAAGAAGCGGTTACAGCAGCTGTTAGTAGTGGTGCAGACTATATCGGTTTTGTTTTTGCCAAAAGTAAACGCCAAGTCAGTCTAGAACAGGCTCAAAAATTAGCTAAAATGATTCCAGAAAAAGTTAAAAAGGTTGGTGTTTTTGTCAGTCCGACTTTGGAGGAATTAAAAATTGCTATAAAGACAGTTCCTCTTGATTTAGTACAGGTTCATGGTGATTATGATGAAGACTTGCAAACTGACTTTTCAGTTCCGCTTATCCGAGCTGTTCAAATTAAAAAAGGTAAAGAAAATTTGACAAGTAAAGCAGATTATCTGCTCTTTGATGCTCCCATAGCTGGCAGTGGTGAAACTTTTGATTGGCAACAGTTGGAGACAGAGCAGTTACAAAAGCCTTTCTTTATTGCAGGTGGACTAACAAGTGATAATGTCAAAGAATGTATTGAACATTTTGCTCCTTATGCTGTTGATGTGTCATCTGGTGTTGAAACAAATGGACGGAAAGATATAGAGAAAATTAAACGATTTATAGAAAGTGTGAAAAAATGA","6.50","-0.61","21279","MTKVKICGLSTQEAVTAAVSSGADYIGFVFAKSKRQVSLEQAQKLAKMIPEKVKKVGVFVSPTLEELKIAIKTVPLDLVQVHGDYDEDLQTDFSVPLIRAVQIKKGKENLTSKADYLLFDAPIAGSGETFDWQQLETEQLQKPFFIAGGLTSDNVKECIEHFAPYAVDVSSGVETNGRKDIEKIKRFIESVKK","502728","For other 'trp' genes see SMu0483 (trpE); SMu0484 (trpG); SMu0485 (trpD); SMu0486 (trpC); SMu0488 (trpB); SMu0489 (trpA). ","phosphoribosylanthranilate isomerase","Cytoplasm","Similarities in gapped BLAST to Phosphoribosylanthranilate isomerase sequences. Residues 1-192 are 66% similar to the enzyme from S.pneumoniae (gi15903675). Residues 4-192 are 54% similar to the enzyme from L.inocua (gi16800738).SMu0487 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001240
Domain

N-(5'phosphoribosyl)anthranilate isomerase (PRAI)
PF00697	$\"[4-190]T$	PRAI

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-192]T$	no description

noIPR
unintegrated

unintegrated
PTHR22854	$\"[2-174]T$	TRYPTOPHAN BIOSYNTHESIS PROTEIN
PTHR22854:SF6	$\"[2-174]T$	N-(5-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE

","BeTs to 10 clades of COG0135COG name: Phosphoribosylanthranilate isomeraseFunctional Class: EThe phylogenetic pattern of COG0135 is amt--qvceb-huj----i--Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 3-189 are 47% similar to a (ISOMERASE TRYPTOPHAN PRAI BIOSYNTHESIS) protein domain (PD001436) which is seen in TRPF_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri May 20 10:08:02 2005","Fri May 20 10:08:02 2005","Fri May 20 10:08:02 2005","Mon Apr 1 14:11:55 2002","","Sun Feb 24 16:18:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0487 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 16:24:31 2002","Fri May 20 10:08:02 2005","pdb1NSJ Crystal Structure Of Phosphoribosyl Anthranilate Is... 112 3e-026pdb1DL3A Chain A, Crystal Structure Of Mutually Generated Mon... 112 4e-026pdb1PII N-(5'phosphoribosyl)anthranilate Isomerase (E.C.5.... 69 5e-013","SMU.536","","Residues 4 to 190 (E-value = 1.8e-57) place SMu0487 in the PRAI family which is described as N-(5'phosphoribosyl)anthranilate (PRA) isomerase (PF00697)","Fri May 20 10:08:02 2005","24379018","","","Bardowski J, Ehrlich SD, Chopin A.Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis.J Bacteriol. 1992 Oct;174(20):6563-70.PMID: 1400208 Ross CM, Kaplan JB, Winkler ME, Nichols BP.An evolutionary comparison of Acinetobacter calcoaceticus trpF with trpF genes of several organisms.Mol Biol Evol. 1990 Jan;7(1):74-81.PMID: 2299982","","Sun Feb 24 16:24:31 2002","1","","","SMU.536","" "SMu0488","502728","503939","1212","ATGACATATAATCAACCCAATAACAACGGTTTTTATGGTAATTTTGGAGGACAATTCATTCCTGAAACGCTGATGACAGCTGTTATTGAATTGGATGAGGCTTATCGTGAAGCCAAAGCTGATCCTAGTTTTCATGAAGAATTAGATGCTCTCTTAAAAGATTATGTTGGTCGTGAAACTCCCTTGTACTTTGCTAAACGTTTGACGGATTATATTGGTGGTGCCAAAATTTATCTAAAACGTGAAGATCTTAATCATACAGGTGCTCACAAAATCAATAATGCACTGGGGCAAGTTCTTTTAGCTAAGCGTATGGGGAAAAATAAGATTATCGCTGAAACAGGTGCAGGACAGCATGGTGTTGCAACAGCGACAGCAGCGGCTCTCTTTGATATGGAATGTACCATTTATATGGGGGAAGAAGATGTGAAACGTCAAGCTCTTAATGTCTTTCGGATGGAGCTATTAGGTGCTAAAGTGCATTCTGTTACGGATGGATCGCGTGTGCTTAAAGATGCAGTCAATGCAGCTTTGCGAGCATGGGTAACCAATATTGAGGATACCCATTATGTTATGGGATCTGCTCTTGGACCAGCTCCTTTCCCAGAAATTGTTCGTGATTTCCAATCGGTTATTGGCAGAGAAGCTAAACGTCAATTTGCGACAGTTTCAAATGGACAGCTGCCAGATGCAGTCTTAGCTTGTATCGGTGGCGGCTCCAATGCAATCGGACTCTTTTATCCTTTTGTCAACGATGAATCAGTTGCCATGTATGGTGCGGAAGCGTCAGGTTTAGGGCTTGATACCGATAAGCATGCGGCAACCTTTGCCAAAGGACGACCAGGTGTTTTACATGGTGCTCTTATGGATGTGCTGCAGGATGAGCATGGACAGATTATGGAAGCTTTCTCGATTTCCGCGGGCCTTGACTATCCAGGTGTTGGTCCTGAACACTGCTATTTCAATGAAATTGGACGTGCAACTTACGATTCTATTACGGATGAAGAAGCTCTGGAATCTTTCAAATTGCTATCTCGTCTGGAAGGCATTATTCCTGCATTAGAATCTAGTCATGCGATTGCTCTGACACAAAAAGTTGCGAAGGAACTAGGAGCGGATAAGTCCATTATTGTTTGCCTCTCAGGACGTGGTGATAAGGATGTGGCTCAGGTTAAAGAACGTCTTAAGCAGGAAGCAAAAGAAGGGAAGTAG","5.30","-11.51","43652","MTYNQPNNNGFYGNFGGQFIPETLMTAVIELDEAYREAKADPSFHEELDALLKDYVGRETPLYFAKRLTDYIGGAKIYLKREDLNHTGAHKINNALGQVLLAKRMGKNKIIAETGAGQHGVATATAAALFDMECTIYMGEEDVKRQALNVFRMELLGAKVHSVTDGSRVLKDAVNAALRAWVTNIEDTHYVMGSALGPAPFPEIVRDFQSVIGREAKRQFATVSNGQLPDAVLACIGGGSNAIGLFYPFVNDESVAMYGAEASGLGLDTDKHAATFAKGRPGVLHGALMDVLQDEHGQIMEAFSISAGLDYPGVGPEHCYFNEIGRATYDSITDEEALESFKLLSRLEGIIPALESSHAIALTQKVAKELGADKSIIVCLSGRGDKDVAQVKERLKQEAKEGK","503936","For other 'trp' genes see SMu0483 (trpE); SMu0484 (trpG); SMu0485 (trpD); SMu0486 (trpC); SMu0487 (trpF); SMu0489 (trpA). For the alpha subunit sequence, see SMu0489.","tryptophan synthase, beta subunit","Cytoplasm","Similarities in gapped BLAST to trpB sequences. Residues 20-403 are 79% similar to the enzyme subunit from S.pneumoniae (gi|15901641) and are 79% similar to the subunit from L.lactis (gi|15673445).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0334 (8e-07).","

InterPro
IPR001926
Domain

Pyridoxal-5'-phosphate-dependent enzyme, beta subunit
PF00291	$\"[53-383]T$	PALP

InterPro
IPR006653
Domain

Tryptophan synthase, beta chain and related
PS00168	$\"[84-98]T$	TRP_SYNTHASE_BETA

InterPro
IPR006654
Family

Tryptophan synthase, beta chain
TIGR00263	$\"[10-395]T$	trpB

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1100	$\"[177-401]T$	G3DSA:3.40.50.1100
PIRSF001413	$\"[1-403]T$	Trp_syn_beta
PTHR10314	$\"[19-398]T$	PTHR10314
PTHR10314:SF3	$\"[19-398]T$	PTHR10314:SF3
SSF53686	$\"[5-395]T$	SSF53686

","BeTs to 12 clades of COG0133COG name: Tryptophan synthase beta chainFunctional Class: EThe phylogenetic pattern of COG0133 is amtkyqVcEbrhuj----i--Number of proteins in this genome belonging to this COG is 1","***** IPB000993 (Tryptophan synthase, beta chain) with a combined E-value of 6.2e-172. IPB000993A 44-68 IPB000993B 100-138 IPB000993C 142-194 IPB000993D 203-252 IPB000993E 255-297 IPB000993F 332-361 IPB000993G 377-388 IPB000993D 202-251***** IPB001926 (Pyridoxal-5'-phosphate-dependent enzymes, beta family) with a combined E-value of 6.8e-15. IPB001926A 111-138 IPB001926B 351-359","Residues 282-388 are 82% similar to a (TRYPTOPHAN SYNTHASE BIOSYNTHESIS PYRIDOXAL PHOSPHATE) protein domain (PD001443) which is seen in TRPB_LACLA.Residues 179-264 are 72% similar to a (TRYPTOPHAN SYNTHASE LYASE PYRIDOXAL PHOSPHATE THREONINE) protein domain (PD002811) which is seen in TRPB_LACLA.Residues 20-58 are 66% similar to a (TRYPTOPHAN SYNTHASE BIOSYNTHESIS PYRIDOXAL PHOSPHATE) protein domain (PD001697) which is seen in TRPB_LACLA.Residues 60-152 are 73% similar to a (TRYPTOPHAN SYNTHASE CHAIN BETA) protein domain (PD278162) which is seen in Q9PIF2_CAMJE.Residues 61-177 are 93% similar to a (SYNTHASE LYASE CYSTEINE PYRIDOXAL PHOSPHATE BIOSYNTHESIS) protein domain (PD000323) which is seen in TRPB_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:13:44 2002","Sun Feb 24 16:32:04 2002","Sun Feb 24 16:39:12 2002","Mon Apr 1 14:12:46 2002","Thu Oct 10 15:13:44 2002","Sun Feb 24 16:32:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0488 is paralogously related (blast p-value < 1e-3) to SMu0212, a predicted threonine dehydratase, and to SMu0449, a predicted cysteine synthetase A.","Sun Feb 24 16:41:08 2002","Sun Feb 24 16:32:04 2002","pdb|1QOP|B Chain B, Crystal Structure Of Wild-Type Tryptophan S... 397 1e-111pdb|1A50|B Chain B, Crystal Structure Of Wild-Type Tryptophan S... 397 1e-111pdb|1BEU|B Chain B, Trp Synthase (D60n-Ipp-Ser) With K+ >gi|321... 397 1e-111","SMU.537","","Residues 53 to 383 (E-value = 5.3e-118) place SMu0488 in the PALP family which is described as Pyridoxal-phosphate dependent enzyme (PF00291)","Sun Feb 24 16:32:04 2002","24379019","","","Kurahashi O, Kawashima H, Nakamori S, Yamane K.Cloning and nucleotide sequence of the Bacillus subtilis K trpB gene encoding tryptophan synthase beta-subunit.Biosci Biotechnol Biochem. 1993 Jun;57(6):1006-9.PMID: 7763866Bardowski J, Ehrlich SD, Chopin A.Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis.J Bacteriol. 1992 Oct;174(20):6563-70.PMID: 1400208 ","","Sun Feb 24 16:39:12 2002","1","","","SMU.537","" "SMu0489","503943","504725","783","ATGACAAAAACACTGACAAAGCATTTACAAGCTATCAAGGCAGAAGGCAAAGGTCTTTTTATTCCTTATATTATGGCTGGGGATCATGATAAAGGTTTAGACGGTCTCTTTGATACCATTTCTTTTTTGGAAGCTCAAGGTGTATCAGCCATTGAAATTGGCATTCCATGGTCGGATCCTGTGGCAGATGGTCCTGTTATTGAATTGGCTGGCCAACGTAGTTTGGTAAAGGGGACATCGCTGGCAAGCATTATTGCTAGGTTACAGGAAAAGAAAACGCAAGTGCCACTTGTTATCATGACTTATTTTAATCCTGTTTTTCAGTATGGTGTTGAAACATTTGTTGCAGATTTGCAAAATACATCTGTCAAAGGATTGATTATTCCCGATTTACCTCATGAACAAGAAAGTTTTATCAAACCTTATCTGGAAAATTTAGATTTAGCTTTAGTTCCTTTAGTCAGCTTAACAACAGGTCTAGAACGTCAAAAGGAACTCATTGAAGATGCTCGAGGATTTGTCTACGCTGTTGCTATTAATGGTGTTACCGGAAAAACAGGGAATTATCGTGATGATTTGGATAAACATTTAAAACATTTGACAGAAATTGCTCAAATCCCTGTTTTAACTGGATTTGGTGTATCAACTTTAGCAGATATTAAGCGCTTTAACCAAGTATCAGATGGTGTCATTGTTGGTTCAAAAATTGTCAAGGGATTACATGAAGGAATGCAAGAAGAAATAAAAGATTTCATTTATGCAGGAAGCCATTATCAAAAATAA","5.70","-5.31","28477","MTKTLTKHLQAIKAEGKGLFIPYIMAGDHDKGLDGLFDTISFLEAQGVSAIEIGIPWSDPVADGPVIELAGQRSLVKGTSLASIIARLQEKKTQVPLVIMTYFNPVFQYGVETFVADLQNTSVKGLIIPDLPHEQESFIKPYLENLDLALVPLVSLTTGLERQKELIEDARGFVYAVAINGVTGKTGNYRDDLDKHLKHLTEIAQIPVLTGFGVSTLADIKRFNQVSDGVIVGSKIVKGLHEGMQEEIKDFIYAGSHYQK","504722","For other 'trp' genes see SMu0483 (trpE); SMu0484 (trpG); SMu0485 (trpD); SMu0486 (trpC); SMu0487 (trpF); SMu0488 (trpB).For the beta subunit, see SMu0488. ","tryptophan synthase, alpha subunit","Cytoplasm","This sequence was previously published in GenBank as gi|8272441. In addition, similarities are seen in gapped BLAST to trpA sequences. Residues 1-260 are 70% similar to the trpA sequence from S.pneumoniae (gi|15901640).SMu0489 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002028
Domain

Tryptophan synthase, alpha chain
PD001535	$\"[1-163]T$	Trp_synthaseA
PF00290	$\"[9-260]T$	Trp_syntA
TIGR00262	$\"[9-256]T$	trpA
PS00167	$\"[51-64]N$	TRP_SYNTHASE_ALPHA

InterPro
IPR011060
Domain

Ribulose-phosphate binding barrel
SSF51366	$\"[2-257]T$	RibP_bind_barrel

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[3-247]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR10314	$\"[57-237]T$	PTHR10314
PTHR10314:SF4	$\"[57-237]T$	PTHR10314:SF4

","BeTs to 12 clades of COG0159COG name: Tryptophan synthase alpha chainFunctional Class: EThe phylogenetic pattern of COG0159 is amt-yqvcebrhuj----i--Number of proteins in this genome belonging to this COG is 1","***** IPB002028 (Tryptophan synthase alpha chain) with a combined E-value of 7.2e-41. IPB002028A 47-68 IPB002028B 96-111 IPB002028C 172-184 IPB002028D 207-223 IPB002028E 227-237","Residues 20-237 are 66% similar to a (TRYPTOPHAN SYNTHASE LYASE BIOSYNTHESIS) protein domain (PD001535) which is seen in TRPA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:14:00 2002","Sun Feb 24 16:33:06 2002","Sun Feb 24 16:50:48 2002","Mon Apr 1 15:17:11 2002","Sun Feb 24 16:33:06 2002","Sun Feb 24 16:33:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0489 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Feb 24 16:44:46 2002","Sun Feb 24 16:33:06 2002","pdb|1GEQ|A Chain A, Entropic Stabilization Of The Tryptophan Sy... 117 2e-027pdb|1QOQ|A Chain A, Crystal Structure Of Wild-Type Tryptophan S... 107 1e-024pdb|1QOP|A Chain A, Crystal Structure Of Wild-Type Tryptophan S... 107 2e-024","SMU.538","","Residues 9 to 257 (E-value = 6e-88) place SMu0489 in the Trp_syntA family which is described as Tryptophan synthase alpha chain (PF00290)","Sun Feb 24 16:33:06 2002","24379020","","Yamamoto,Y., Higuchi,M., Poole,L.B. and Kamio,Y.Role of the dpr product in oxygen tolerance in Streptococcus mutansJ. Bacteriol. 182 (13), 3740-3747 (2000)PubMed: 10850989","Muller-Graf CD, Whatmore AM, King SJ, Trzcinski K, Pickerill AP, Doherty N, Paul J, Griffiths D, Crook D, Dowson CG.Population biology of Streptococcus pneumoniae isolated from oropharyngeal carriage and invasive disease.Microbiology. 1999 Nov;145 ( Pt 11):3283-93.PMID: 10589738Bardowski J, Ehrlich SD, Chopin A.Tryptophan biosynthesis genes in Lactococcus lactis subsp. lactis.J Bacteriol. 1992 Oct;174(20):6563-70.PMID: 1400208","Mon Apr 1 15:18:16 2002","Sun Feb 24 16:50:48 2002","1","","","SMU.538","" "SMu0490","505618","504962","657","ATGAAACTTATTTTATTTTTTATGTTGGGAGCTTCTCTTGGCTCTTTCTTTGGCTTAGTTGTTGATCGTTACCCTCAGAAATCTATTATATTTCCTAGAAGCCATTGCAATAAGTGTTATAACTGCTTAACCATGAGGGATCTTATCCCAATATTTTCACGAATCATCAACAAAAATTCTTGTCGCTTTTGCGGTTACCCTATTCCATTGCGTTATTCTTTGGTAGAATTACTCTGCGGACTGATTAGCACAGGTTTTGCTCTTGATTTATTAACCACTTCACAAGTATGTTTGCTCTTCATGGGAGTTCTTTTATCTCTTTATGATTTACAAGATCAGTCTTATCCTTTGACACTGTGGATAGGCTTTACTTTTCTCTTAATGTTTATCTATCCTCTTAACCTAATTAGCTTAATTCTTTTTCTATTTGGTATTTTTGCTGCCCTCAAAAATATTAATATCGGAAGCGGTGATTTCCTCTATCTGGCTACTTTGGCACTTTCTCTTAATCTTCAGCAAATTATTTGGATTATTCAGATTGCCAGTTTATTAGGAATTCTTTACAGCCTGCTTTTTCAAAAGCACAAAGAACCTTTTGCTTTTGTTCCTTTCTTATTCGTGGGTCACCTCATTATCATTTTCTCTCACTTGATTTAA","8.50","5.61","24830","MKLILFFMLGASLGSFFGLVVDRYPQKSIIFPRSHCNKCYNCLTMRDLIPIFSRIINKNSCRFCGYPIPLRYSLVELLCGLISTGFALDLLTTSQVCLLFMGVLLSLYDLQDQSYPLTLWIGFTFLLMFIYPLNLISLILFLFGIFAALKNINIGSGDFLYLATLALSLNLQQIIWIIQIASLLGILYSLLFQKHKEPFAFVPFLFVGHLIIIFSHLI","504965","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0451 (comF);SMu0452 (comFC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).","prepilin peptidase type IV","Membrane, Cytoplasm, Extracellular","This sequence has been previously reported in GenBank as gi8272442, a type IV prepilin peptidase homolog. In addition, residues 1-218 are 34% similar to gi15674010 of L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0469 (2e-12).","

InterPro
IPR000045
Domain

Peptidase A24A, prepilin type IV
PF01478	$\"[96-190]T$	Peptidase_A24

InterPro
IPR010627
Domain

Peptidase A24A, N-terminal
PF06750	$\"[8-89]T$	DiS_P_DiS

noIPR
unintegrated

unintegrated
PIRSF001215	$\"[1-218]T$	TcpJ

","BeTs to 5 clades of COG1989COG name: Signal peptidase HopD, cleaves prepilin-like proteinsFunctional Class: NThe phylogenetic pattern of COG1989 is -----qvcEb-h---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 25-77 are identical to a (PEPTIDASE LEADER ENZYME TYPE) protein domain (PD002740) which is seen in Q9KWH4_STRMU.Residues 88-218 are 67% similar to a (PEPTIDASE TYPE PROTEOME PREPILIN-LIKE) protein domain (PD297240) which is seen in Q9KWH4_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 08:30:40 2006","Thu Aug 31 08:30:40 2006","Thu Aug 31 08:30:40 2006","Thu Apr 4 10:12:16 2002","","Mon Feb 25 09:58:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0490 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 10:02:47 2002","","No significant hits to the NCBI PDB database.","SMU.539c","","Residues 8 to 89 (E-value = 9.4e-42) place SMu0490 in the DiS_P_DiS family which is described as Bacterial Peptidase A24 N-terminal domain (PF06750)Residues 96 to 190 (E-value = 7.3e-18) place SMu0490 in the Peptidase_A24 family which is described as Type IV leader peptidase family (PF01478)","Thu Aug 31 08:30:40 2006","24379021","","Yamamoto,Y., Higuchi,M., Poole,L.B. and Kamio,Y.Role of the dpr product in oxygen tolerance in Streptococcus mutansJ. Bacteriol. 182 (13), 3740-3747 (2000)PubMed: 20309704","LaPointe CF, Taylor RK.The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases.J Biol Chem. 2000 Jan 14;275(2):1502-10.PMID: 10625704 ","Thu Aug 31 08:30:40 2006","Mon Feb 25 10:04:43 2002","1","","","SMU.539c","1007" "SMu0491","505719","506246","528","ATGACGAATACAATTACTGAAAATATCTACGCTTCTATTATTCATCAAGTGGAGAAAAAAGAAAATTCAGGAAATGAAAAAACCAAGGCTGTACTTAATCAGGCTGTAGCGGATTTATCAAAAGCAACTTCCATTGTTCACCAAGTCCATTGGTATATGCGTGGTTCAGGCTTCCTTTATCTGCATCCTAAAATGGATGAATTGATGGATGCCTTGAATGGTCATCTTGATGAGATTAGTGAACGCTTGATTACTATCGGTGGCGCTCCGTTTTCAACCTTGAAAGAATTTGATGAGAATTCCAGACTTGAAGAAACAGTTGGCACATGGGATAAATCAATAACTGATCATCTTAAACGCCTTGTTCAAGTTTATGATTACCTTTCAAGTCTTTATCAAGTAGGTCTTGATGTGACAGATGAGGAAGGTGATGCTGTTTCTAATGATATCTTTACAGCAGCTCAAACGGAAGCCCAAAAGACAATCTGGATGTTGCAGGCAGAGCTTGGGCAAGCTCCCGGTTTATAA","4.60","-11.55","19573","MTNTITENIYASIIHQVEKKENSGNEKTKAVLNQAVADLSKATSIVHQVHWYMRGSGFLYLHPKMDELMDALNGHLDEISERLITIGGAPFSTLKEFDENSRLEETVGTWDKSITDHLKRLVQVYDYLSSLYQVGLDVTDEEGDAVSNDIFTAAQTEAQKTIWMLQAELGQAPGL","506243","","peroxide resistance protein / iron binding protein","Cytoplasm","This sequence corresponds to the previously published gi8272443, gi11356483 in GenBank. In addition, residues 28-175 are 65% similar to gi11276051 of S.suis.SMu0491 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002177
Family

DNA-binding protein Dps
PD149803	$\"[46-105]T$	DPS
PR01346	$\"[50-66]T$ $\"[74-90]T$ $\"[147-165]T$	HELNAPAPROT
PIRSF005900	$\"[18-172]T$	Dps
PS00818	$\"[50-66]T$	DPS_1

InterPro
IPR008331
Family

Ferritin and Dps
PF00210	$\"[29-175]T$	Ferritin

InterPro
IPR009078
Family

Ferritin/ribonucleotide reductase-like
SSF47240	$\"[1-175]T$	Ferritin/RR_like

InterPro
IPR012347
Family

Ferritin-related
G3DSA:1.20.1260.10	$\"[11-175]T$	Ferritin_rel

","BeTs to 7 clades of COG0783COG name: Starvation-inducible DNA-binding protein DpsFunctional Class: LThe phylogenetic pattern of COG0783 is -------ceB-huj--ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB002177 (Dps protein family) with a combined E-value of 1e-37. IPB002177A 32-72 IPB002177B 73-87 IPB002177C 144-169","Residues 1-31 are identical to a (DPR) protein domain (PD225434) which is seen in Q9KWH3_STRMU.Residues 22-167 are 27% similar to a (DNA-BINDING TANGLED SUBUNIT FINE) protein domain (PD293071) which is seen in DPS_ECOLI.Residues 32-169 are 98% similar to a (PROTEOME COMPLETE DNA-BINDING NEUTROPHIL) protein domain (PD149803) which is seen in Q9KWH3_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:07:48 2002","Mon Oct 28 14:23:11 2002","Thu Feb 3 15:05:37 2005","Mon Oct 28 14:23:11 2002","Mon Feb 25 10:05:32 2002","Mon Feb 25 10:05:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0491 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 10:07:48 2002","Thu Feb 3 15:05:37 2005","pdb1QGHA Chain A, The X-Ray Structure Of The Unusual Dodecame... 139 3e-034pdb1DPSA Chain A, The Crystal Structure Of Dps, A Ferritin Ho... 70 1e-013","SMU.540","","Residues 29 to 175 (E-value = 3.4e-38) place SMu0491 in the Ferritin family which is described as Ferritin-like domain (PF00210)","Mon Feb 25 10:05:32 2002","24379022","","Yamamoto,Y., Higuchi,M., Poole,L.B. and Kamio,Y.Role of the dpr product in oxygen tolerance in Streptococcus mutansJ. Bacteriol. 182 (13), 3740-3747 (2000)PubMed: 20309704Yamamoto Y, Poole LB, Hantgan RR, Kamio Y. An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.J Bacteriol. 2002 Jun;184(11):2931-9.PMID: 12003933Yamamoto,Y., Higuchi,M., Poole,L.B. and Kamio,Y.Identification of a new gene responsible for the oxygen tolerancein aerobic life of Streptococcus mutansBiosci. Biotechnol. Biochem. 64 (5), 1106-1109 (2000)PubMed: 20335842Yamamoto Y, Fukui K, Koujin N, Ohya H, Kimura K, Kamio Y.Regulation of the intracellular free iron pool by Dpr provides oxygen tolerance to Streptococcus mutans.J Bacteriol. 2004 Sep;186(18):5997-6002.PMID: 15342568","Niven DF, Ekins A. Iron content of Streptococcus suis and evidence for a dpr homologue.Can J Microbiol. 2001 May;47(5):412-6.PMID: 11400731","Wed Sep 27 12:57:21 2006","Sat Oct 26 17:22:59 2002","1","","","SMU.540","" "SMu0492","506453","506659","207","ATGAAAACATTATATGATGTGCAGCGGCTGTTAAAACAATTTGGCATCTATGTTTATTTAGGTAAACGTCTTTATGATATTGAAATGATGAAAATTGAGTTAGAAAGACTCTATGATAATGGTTTGATTTCAAAGAGTGATTATCTACATGCTGAATTGATTTTACGCAGGGAGCACAGAATAGAAAAGGAAAGAGAAAATGGCTAA","9.10","1.47","8332","MKTLYDVQRLLKQFGIYVYLGKRLYDIEMMKIELERLYDNGLISKSDYLHAELILRREHRIEKERENG","506656","","conserved hypothetical protein","Cytoplasm","This sequence corresponds to the previously published gi|8272444 in GenBank. In addition, residues 1-66 are 81% similar to gi|15675429 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0470 (4e-28).","

InterPro
IPR009256
Family

Protein of unknown function DUF910, bacterial
PF06014	$\"[1-62]T$	DUF910

noIPR
unintegrated

unintegrated
PD027553	$\"[1-64]T$	PD027553

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-67 are 98% similar to a (PROTEOME COMPLETE SODA-COMGA ORF1) protein domain (PD027553) which is seen in Q9KWH2_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:14:42 2002","Mon Feb 25 10:14:42 2002","Mon Feb 25 10:14:42 2002","Mon Feb 25 10:14:42 2002","","Mon Feb 25 10:14:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0492 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 10:14:42 2002","","No significant hits to the NCBI PDB database.","SMU.541","","Residues 1 to 62 (E-value = 1.1e-40) place SMu0492 in the DUF910 family which is described as Bacterial protein of unknown function (DUF910) (PF06014)","Mon Feb 25 10:14:42 2002","24379023","","Yamamoto,Y., Higuchi,M., Poole,L.B. and Kamio,Y.Role of the dpr product in oxygen tolerance in Streptococcus mutansJ. Bacteriol. 182 (13), 3740-3747 (2000)PubMed: 20309704","","Mon Feb 25 10:14:42 2002","","1","","","SMU.541","900" "SMu0493","506652","507623","972","ATGGCTAAGAAACTTTTAGGGATTGATCTTGGTGGAACAAGTATTAAATTTGGGATTTTAACTTTAGATGGACAAGTTCAGGAGAAATGGGCTATTGAAACCAATATTTTGGAAGATGGGAAACATATTGTTCCAGATATTGTGTCCTCTATCAAGCATCGTTTGGAACTCTATAATTTAACTAAGGAGGATTTTGTTGGTATTGGAATGGGATCTCCTGGAGCTGTGGATCGTAATCTAAAGACTGTTACAGGTGCTTTTAATCTTAATTGGGCTGCTACCCAAGAGGTAGGAACAATAATTGAAGCAGAATTGGGGATACCATTTGCTATTGATAATGATGCTAATGTTGCAGCACTTGGAGAACGCTGGGTTGGTGCGGGTAATAATAATCCTGATGTTGTCTTTGTAACACTTGGTACAGGTGTTGGCGGCGGCATTATTGCTGATGGCAATCTTATTCATGGAGTTGCTGGTGCAGGTGGTGAAATTGGACATATTATTGTTGAGCCGGATACTGGTTTTGAGTGTACCTGTGGCAATAAAGGCTGTCTTGAAACAGTGGCTTCAGCAACAGGTGTCGTCCGTGTTGCACGTCATTTAGCAGAAGAATATGAAGGTATTTCCAGTATTAAAGCGGGCATTGATAATGGTGATGATGTGAGCAGTAAGGATATTTTTGTTGCTGCACAGGCAGGTGATAAATTTGCAAACTCAGTTGTTGAGAAAGTTACTTTCTATCTAGGCCTTGCAACCGCCAATATCAGCAATATCCTTAATCCAAACACAGTTGTCGTTGGAGGTGGAGTATCAGCTGCTGGAGAATTCTTGCGCTCACATATTGAAAGTTATTTTAAATTGTATGCTTTTCCACAAGTGAAGCAATCTACAAAAATTAAAATTGCAGAATTAGGAAATGACGCTGGTATTATTGGGGCAGCCAGTCTTGCACATCAGTTTTTAGAAAGTTAA","4.70","-13.44","33621","MAKKLLGIDLGGTSIKFGILTLDGQVQEKWAIETNILEDGKHIVPDIVSSIKHRLELYNLTKEDFVGIGMGSPGAVDRNLKTVTGAFNLNWAATQEVGTIIEAELGIPFAIDNDANVAALGERWVGAGNNNPDVVFVTLGTGVGGGIIADGNLIHGVAGAGGEIGHIIVEPDTGFECTCGNKGCLETVASATGVVRVARHLAEEYEGISSIKAGIDNGDDVSSKDIFVAAQAGDKFANSVVEKVTFYLGLATANISNILNPNTVVVGGGVSAAGEFLRSHIESYFKLYAFPQVKQSTKIKIAELGNDAGIIGAASLAHQFLES","507620","","glucose kinase","Cytoplasm","Matches in gapped BLAST to glucose kinases. Residues 1-318 are 75% similar to gi17066734 from S.thermophilus. Residues 1-321 are 74% similar to gi15675428 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0471 (1e-139).","

InterPro
IPR000600
Family

ROK
PF00480	$\"[7-194]T$	ROK
PS01125	$\"[139-166]T$	ROK

InterPro
IPR004654
Family

Glucokinase ROK
TIGR00744	$\"[6-321]T$	ROK_glcA_fam

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.160	$\"[114-314]T$	G3DSA:3.30.420.160
PTHR18964	$\"[71-206]T$ $\"[224-323]T$	PTHR18964
PTHR18964:SF37	$\"[71-206]T$ $\"[224-323]T$	PTHR18964:SF37

","BeTs to 8 clades of COG1940COG name: Transcriptional regulators of NagC/XylR familyFunctional Class: KThe phylogenetic pattern of COG1940 is a-t--qVcEBRH----O----Number of proteins in this genome belonging to this COG is 2","***** IPB000600 (ROK family) with a combined E-value of 2.1e-26. IPB000600A 7-14 IPB000600B 108-122 IPB000600C 139-148 IPB000600D 161-167 IPB000600E 177-186","Residues 73-126 are 44% similar to a (PROTEOME COMPLETE REPRESSOR XYLOSE) protein domain (PD212372) which is seen in XYLR_CALSR.Residues 64-165 are 28% similar to a (TRANSCRIPTIONAL REGULATORY ROK-FAMILY) protein domain (PD121382) which is seen in Q9S2D8_STRCO.Residues 86-149 are 62% similar to a (KINASE PROTEOME COMPLETE GLUCOSE) protein domain (PD371512) which is seen in Q9CE25_LACLA.Residues 151-285 are 63% similar to a (KINASE PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD406424) which is seen in Q9CE25_LACLA.Residues 152-261 are 50% similar to a (KINASE COMPLETE PROTEOME REPRESSOR) protein domain (PD001669) which is seen in Q9KCZ4_BACHD.Residues 6-83 are 74% similar to a (KINASE GLUCOSE PROTEOME COMPLETE) protein domain (PD222994) which is seen in Q9CE25_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:21:12 2002","Mon Feb 25 10:15:44 2002","Thu Apr 22 14:00:35 2004","Thu Apr 22 14:00:35 2004","Mon Feb 25 10:15:44 2002","Mon Feb 25 10:15:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0493 is paralogously related (blast p-value < 1e-3) to SMu1676, a predicted fructokinase.","Mon Feb 25 10:22:08 2002","","No significant hits to the NCBI PDB database.","SMU.542","","Residues 7 to 194 (E-value = 2.7e-46) place SMu0493 in the ROK family which is described as ROK family (PF00480)","Mon Feb 25 10:15:44 2002","24379024","","","Skarlatos P, Dahl MK.The glucose kinase of Bacillus subtilis.J Bacteriol. 1998 Jun;180(12):3222-6.PMID: 9620975","Tue Nov 5 08:55:19 2002","Mon Feb 25 10:21:12 2002","1","","","SMU.542","278" "SMu0494","507633","508022","390","ATGTCAATTATCTCTATCATTTCGTGGGTTATTATCTTTGCCTTTGTGGCTTGGTTTGTTTGGAATTATTTTCGTGTTCGCCGTGCTGCCCAGTATATCTCAAATGCTGAATTTGAAAGCATGATGAGAGGCGCACAAATTGTTGATTTGCGTTCTCCCAATGAGTTTCGTCGTAAGCATATCTTAGGAGCTCGTAATCTTCCCTCTGAACAATTCAAAGCATCTGTTTCAGCTCTTCGCAAAGATAAACCGGTTTTATTGTATGATAATACTCGTGGACAGCTGGTTGCTCGCGCTGTTTTAACTTTGAAAAAGGCAGGTTATAAAGATCTTTATGTCCTTAAAAATGGTTTAGATAATTGGAATGGAAAAGTAAAAGAGAAGAATTAG","11.10","12.22","14951","MSIISIISWVIIFAFVAWFVWNYFRVRRAAQYISNAEFESMMRGAQIVDLRSPNEFRRKHILGARNLPSEQFKASVSALRKDKPVLLYDNTRGQLVARAVLTLKKAGYKDLYVLKNGLDNWNGKVKEKN","508019","","conserved hypothetical protein","Periplasm, Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 14-126 are 59% similar to gi|15900579 from S.pneumoniae. Residues 16-127 are 54% similar to gi|15675427 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0472 (4e-37).","

InterPro
IPR001763
Domain

Rhodanese-like
PF00581	$\"[34-124]T$	Rhodanese
SM00450	$\"[31-127]T$	RHOD
PS50206	$\"[41-127]T$	RHODANESE_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.250.10	$\"[27-123]T$	G3DSA:3.40.250.10
SSF52821	$\"[1-127]T$	SSF52821

","BeTs to 6 clades of COG0607COG name: Rhodanese-related sulfurtransferasesFunctional Class:� PThe phylogenetic pattern of COG0607 is amT-YQ-CEBRHuj--o---xNumber of proteins in this genome belonging to this COG is 2","***** PR00716 (M-phase inducer phosphatase signature) with a combined E-value of 2.4e-06. PR00716C 47-67 PR00716E 101-122","Residues 19-126 are 48% similar to a (PROTEOME YVAB COMPLETE) protein domain (PD395617) which is seen in Q9CE24_LACLA.Residues 47-121 are 37% similar to a (PROTEOME COMPLETE BU052 PM1433) protein domain (PD299733) which is seen in YIBN_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:26:03 2002","Mon Feb 25 10:25:09 2002","Mon Feb 25 10:26:03 2002","Mon Feb 25 10:25:09 2002","Mon Feb 25 10:25:09 2002","Mon Feb 25 10:25:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0494 is paralogously related (blast p-value < 1e-3) to SMu1786, a conserved hypothetical..","Mon Feb 25 10:26:03 2002","","No significant hits to the NCBI PDB database.","SMU.543","","Residues 34 to 124 (E-value = 5.9e-19) place SMu0494 in the Rhodanese family which is described as Rhodanese-like domain (PF00581)","Mon Feb 25 10:25:09 2002","24379025","","","","","","1","","","SMU.543","" "SMu0495","508090","508230","141","TTGAGGACTTATTTTATAAAATTTGGAGATACCAAGACTGCGACTTTGCTATCTTGGTTTTTCTTTTATATTTTAAAACATTTACATATCTCTCCTGAGTTTTTCCCTAATTTTTATGGTATAATAGATAAGTTGAAATAA","10.40","3.46","5601","MRTYFIKFGDTKTATLLSWFFFYILKHLHISPEFFPNFYGIIDKLK","508227","","hypothetical protein","Cytoplasm, Extracellular","No significant matched in gapped BLAST.SMu0495 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:38:36 2002","Mon Feb 25 10:38:36 2002","Mon Feb 25 10:38:36 2002","Mon Feb 25 10:38:36 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0495 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 10:38:36 2002","","No significant hits to the NCBI PDB database.","SMU.545","","No significant hits to the Pfam 11.0 database","Mon Feb 25 10:38:36 2002","24379026","","","","","","1","","","SMU.545","" "SMu0496","508256","510100","1845","ATGACAAATTTTAGAGAAGATATTAGAAATGTTGCTATCATTGCCCACGTTGACCATGGGAAAACAACCCTTGTTGATGAGCTCTTAAAACAATCGCATACACTTGATGAGCATAAAAAATTAGAAGAACGTGCGATGGACTCTAATGATCTTGAAAAAGAGCGTGGGATTACTATTCTTGCAAAAAATACTGCTGTTGCCTACAATGGTGTACGTATTAACATTATGGACACACCAGGACATGCGGATTTTGGTGGAGAAGTAGAGCGTATCATGAAAATGGTTGATGGGGTTGTTCTTGTTGTTGATGCTTATGAAGGTACCATGCCGCAAACACGTTTTGTTTTGAAAAAAGCTTTGGAACAAAACCTGGTTCCAATCGTGGTGGTGAATAAGATTGACAAGCCATCAGCTCGTCCGGCAGAAGTTGTTGATGAAGTTCTTGAACTTTTCATTGAACTTGGAGCAGATGATGACCAGTTAGAGTTTCCAGTCGTTTACGCTTCGGCGATTAATGGAACTTCTTCATTATCAGATGAACCAGCGGATCAAGAACATACAATGGCACCCGTTTTTGATACTATTATTGAGCATATTCCAGCACCGATCGATAATTCAGATCAGCCACTTCAATTTCAAGTGTCTCTCCTTGATTATAACGACTTTGTTGGACGTATCGGTATTGGGCGAGTCTTCCGTGGTTCTGTTAAAGTCGGGGATCAAGTGACACTTTCTAAACTTGATGGTACAACAAAGAATTTTCGTGTTACAAAACTTTTCGGTTTCTTCGGTTTGGAACGTCGTGAGATTAAGGAAGCTAAGGCTGGCGATTTGATTGCTGTTTCAGGTATGGAAGATATCTTTGTTGGTGAAACGATTACACCAACTGATGCTGTAGAACCACTTCCTATTCTTCACATTGATGAGCCAACTCTGCAAATGACCTTTTTAGCTAACAATTCCCCTTTTGCAGGCCGTGAAGGTAAATTTGTAACCTCGCGTAAGGTAGAAGAGCGTTTGTTGGCAGAATTGCAAACAGATGTTTCCCTTCGTGTAGAAGCCACTGACTCACCAGATAAATGGACGGTTTCAGGTCGTGGGGAGTTACATCTGTCAATCCTTATTGAAACCATGCGCCGTGAAGGATATGAGCTGCAAGTATCGCGTCCAGAAGTTATTATCAAAGAAATTGATGGCATCAAATGTGAGCCATTTGAACGCGTGCAAATTGACACACCGGAAGAATACCAAGGTGCTGTTATCCAGTCCCTTTCAGAACGTAAAGGTGAAATGCTTGATATGCAAGCAACTGGTAATGGTCAAACGCGCCTTATATTTTTAGCACCAGCTCGAGGACTTATCGGCTACCCAACAGAATTCTTATCCATGACACGAGGTTATGGTATCATGAACCACACTTTTGACAAATATATGCCAGTTATCAATGCTGAAATCGGTGGTCGTCATCGTGGTGCCCTCGTTTCAATTGATACAGGTAAGGCAACGACTTATTCTATTATGTCTATTGAAGAACGTGGAACAATCTTCGTTAACCCAGGTACAGAAGTGTATGAAGGAATGATTATTGGAGAAAATGCACGCGAGAATGATTTGACAGTCAACATTACAAAGGCTAAGCAGATGACTAATGTGCGCTCTGCAACCAAGGATCAGACAGCAGTTATTAAGACGCCGCGTATTTTAACACTTGAAGAATCACTTGAGTTTCTGAATGATGATGAATACATGGAAGTAACACCTGAGTCCATTCGTTTACGTAAACAAATTCTTGATAAGAATGCGCGTGCTAAAGCGGCTAAGAAGAAAAAATCAGCTGAAGATTGA","4.80","-25.30","68419","MTNFREDIRNVAIIAHVDHGKTTLVDELLKQSHTLDEHKKLEERAMDSNDLEKERGITILAKNTAVAYNGVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQNLVPIVVVNKIDKPSARPAEVVDEVLELFIELGADDDQLEFPVVYASAINGTSSLSDEPADQEHTMAPVFDTIIEHIPAPIDNSDQPLQFQVSLLDYNDFVGRIGIGRVFRGSVKVGDQVTLSKLDGTTKNFRVTKLFGFFGLERREIKEAKAGDLIAVSGMEDIFVGETITPTDAVEPLPILHIDEPTLQMTFLANNSPFAGREGKFVTSRKVEERLLAELQTDVSLRVEATDSPDKWTVSGRGELHLSILIETMRREGYELQVSRPEVIIKEIDGIKCEPFERVQIDTPEEYQGAVIQSLSERKGEMLDMQATGNGQTRLIFLAPARGLIGYPTEFLSMTRGYGIMNHTFDKYMPVINAEIGGRHRGALVSIDTGKATTYSIMSIEERGTIFVNPGTEVYEGMIIGENARENDLTVNITKAKQMTNVRSATKDQTAVIKTPRILTLEESLEFLNDDEYMEVTPESIRLRKQILDKNARAKAAKKKKSAED","510097","","GTP-binding protein (tyrosine phosphorylated protein A); possible elongation factor","Cytoplasm","Matches in gaped BLAST to GTP-binding proteins. Residues 1-598 are 90% similar to gi|15675426, a predicted TypA/BipA protein from S.pyogenes and are also 90% similar to gi|15900582, a predicted Tu family elongation factor protein from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0473 (0.0).","

InterPro
IPR000640
Domain

Translation elongation factor EFG/EF2, C-terminal
G3DSA:3.30.70.240	$\"[403-492]T$	Transl_elong_EFG/EF2_C
PF00679	$\"[400-485]T$	EFG_C

InterPro
IPR000795
Domain

Protein synthesis factor, GTP-binding
PR00315	$\"[10-23]T$ $\"[54-62]T$ $\"[74-84]T$ $\"[90-101]T$ $\"[126-135]T$	ELONGATNFCT
PF00009	$\"[6-203]T$	GTP_EFTU
PS00301	$\"[47-62]T$	EFACTOR_GTP

InterPro
IPR004161
Domain

Translation elongation factor EFTu/EF1A, domain 2
PF03144	$\"[224-294]T$	GTP_EFTU_D2

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[6-180]T$	small_GTP

InterPro
IPR006298
Family

GTP-binding protein TypA
TIGR01394	$\"[8-604]T$	TypA_BipA

InterPro
IPR009000
Domain

Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447	$\"[154-305]T$	Translat_factor

InterPro
IPR009022
Domain

Elongation factor G, III and V
SSF54980	$\"[335-391]T$ $\"[403-528]T$	EFG_III_V

noIPR
unintegrated

unintegrated
G3DSA:2.40.30.10	$\"[205-306]T$	G3DSA:2.40.30.10
G3DSA:3.40.50.300	$\"[5-205]T$	G3DSA:3.40.50.300
PTHR23115	$\"[5-326]T$	PTHR23115
PTHR23115:SF14	$\"[5-326]T$	PTHR23115:SF14
SSF52540	$\"[1-213]T$	SSF52540

","BeTs to 6 clades of COG1217COG name: Membrane GTPaseFunctional Class: NThe phylogenetic pattern of COG1217 is -------cebrhuj------xNumber of proteins in this genome belonging to this COG is 1","***** IPB000640 (Elongation factor G, C-terminus) with a combined E-value of 1.5e-53. IPB000640A 8-33 IPB000640B 46-68 IPB000640C 73-100 IPB000640D 107-135 IPB000640E 191-202 IPB000640F 397-431***** IPB000795 (GTP-binding elongation factor) with a combined E-value of 3.7e-30. IPB000795A 10-25 IPB000795B 76-107 IPB000795C 111-135***** IPB000178 (Initiation factor 2) with a combined E-value of 8.8e-19. IPB000178A 7-45 IPB000178B 73-105 IPB000178C 106-145","Residues 93-173 are 96% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in Q9CE33_LACLA.Residues 304-416 are 92% similar to a (GTP-BINDING PROTEOME COMPLETE TYPA/BIPA) protein domain (PD011418) which is seen in Q9CE33_LACLA.Residues 420-479 are 81% similar to a (GTP-BINDING ELONGATION FACTOR BIOSYNTHESIS PROTEOME) protein domain (PD011419) which is seen in Q9CE33_LACLA.Residues 199-303 are 62% similar to a (GTP-BINDING PROTEOME COMPLETE FACTOR) protein domain (PD004660) which is seen in TYPA_BACSU.Residues 484-594 are 70% similar to a (GTP-BINDING PROTEOME COMPLETE TYPA/BIPA) protein domain (PD407411) which is seen in Q9K9L3_BACHD.Residues 51-84 are 73% similar to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS 1-ALPHA) protein domain (PD350470) which is seen in TYPA_HELPY.Residues 87-151 are 55% similar to a (FACTOR ELONGATION GTP-BINDING) protein domain (PD404337) which is seen in O82278_ARATH.Residues 20-149 are 36% similar to a (GTP-BINDING ADP-RIBOSYLATION MULTIGENE FAMILY ALPHA) protein domain (PD076602) which is seen in IF2_THEMA.Residues 65-155 are 30% similar to a (FACTOR ELONGATION GTP-BINDING LIKE) protein domain (PD302693) which is seen in EFGL_MYCTU.Residues 254-303 are 86% similar to a (GTP-BINDING TYPA/BIPA HOMOLOG PROTEOME) protein domain (PD348560) which is seen in Q9CE33_LACLA.Residues 52-84 are 87% similar to a (FACTOR GTP-BINDING BIOSYNTHESIS INITIATION ELONGATION) protein domain (PD336744) which is seen in Q9RV32_DEIRA.Residues 253-303 are 47% similar to a (PROTEOME GTP-BINDING COMPLETE FACTOR) protein domain (PD399323) which is seen in Q9HU67_PSEAE.Residues 198-252 are 63% similar to a (GTP-BINDING PROTEOME COMPLETE TYPA/BIPA) protein domain (PD383618) which is seen in Q9CE33_LACLA.Residues 13-135 are 34% similar to a (C215.12 GTP-BINDING CHROMOSOME II) protein domain (PD196535) which is seen in O94316_SCHPO.Residues 87-135 are 51% similar to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS RESISTANCE) protein domain (PD368385) which is seen in EF2_METBU.Residues 6-49 are 86% similar to a (GTP-BINDING FACTOR ELONGATION BIOSYNTHESIS RESISTANCE) protein domain (PD000122) which is seen in Q9CE33_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 11:20:34 2002","Mon Feb 25 11:20:34 2002","Wed Oct 23 18:16:04 2002","Wed Oct 23 18:16:04 2002","Mon Feb 25 10:39:52 2002","Mon Feb 25 10:39:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0496 is paralogously related (blast p-value < 1e-3) to SMu1271, SMu0324, SMu0651, SMu0554, SMu0382, and SMu1744, GTP-binding proteins.","Mon Feb 25 11:20:34 2002","Mon Feb 25 10:39:52 2002","pdb|1FNM|A Chain A, Structure Of Thermus Thermophilus Ef-G H573a 111 2e-025pdb|1ELO| Elongation Factor G Without Nucleotide >gi|1633250|... 111 2e-025pdb|2EFG|A Chain A, Translational Elongation Factor G Complexed... 109 7e-025","SMU.546","","Residues 6 to 203 (E-value = 2e-66) place SMu0496 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)Residues 224 to 294 (E-value = 1.1e-16) place SMu0496 in the GTP_EFTU_D2 family which is described as Elongation factor Tu domain 2 (PF03144)Residues 400 to 488 (E-value = 3e-35) place SMu0496 in the EFG_C family which is described as Elongation factor G C-terminus (PF00679)","Mon Feb 25 10:39:52 2002","24379027","","","","","","1","","","SMU.546","58" "SMu0497","510129","510383","255","ATGTTTTATGCTATCATCGCTATTTTGCTTTTAATGTATTACATTTTTATTGCTCCTAAGACAATTAAAAATACCATGAACATGATTTCCGTGGTGGGAATTATCGCTTTCCTGATGGTCTTAGCAGGCATGACTTTTATTCGGATCATACAGTCACCACCTGAGATTTTTATTGGAATCGGTATGATTATTGTTGGTTATTATGCTTTGAAAGATGTTTTGCATTTACGAACGAGACCTAAAAATAAAAGATAA","11.00","7.22","9592","MFYAIIAILLLMYYIFIAPKTIKNTMNMISVVGIIAFLMVLAGMTFIRIIQSPPEIFIGIGMIIVGYYALKDVLHLRTRPKNKR","510380","","conserved hypothetical protein","Membrane, Cytoplasm","Weak matches in gapped BLAST to conserved hypothetical proteins. Residues 19-84 are 33% similar to gi|15900583 from S.pneumoniae. Residues 19-83 are 53% similar to gi|15675425 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0474 (7e-15).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-19]?$	signal-peptide
tmhmm	$\"[4-18]?$ $\"[28-50]?$ $\"[56-74]?$	transmembrane_regions

InterPro
IPR004101
Domain

Cytoplasmic peptidoglycan synthetases, C-terminal
PF02875	$\"[310-385]T$	Mur_ligase_C

InterPro
IPR005762
Family

UDP-N-acetylmuramoylalanine-D-glutamate ligase
TIGR01087	$\"[11-447]T$	murD

InterPro
IPR012237
Family

UDP-N-acetylmuramate-alanine ligase
PIRSF001562	$\"[10-451]T$	UDP-NAcM_Alig

InterPro
IPR013221
Domain

Mur ligase, middle region
PF08245	$\"[115-290]T$	Mur_ligase_M

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.10	$\"[101-309]T$	G3DSA:3.40.1190.10
G3DSA:3.40.50.720	$\"[5-100]T$	G3DSA:3.40.50.720
G3DSA:3.90.190.20	$\"[310-449]T$	G3DSA:3.90.190.20
PTHR23135	$\"[117-450]T$	PTHR23135
PTHR23135:SF2	$\"[117-450]T$	PTHR23135:SF2
SSF51984	$\"[5-101]T$	SSF51984
SSF53244	$\"[309-449]T$	SSF53244
SSF53623	$\"[102-307]T$	SSF53623

","BeTs to 12 clades of COG0771COG name: UDP-N-acetylmuramoylalanine-D-glutamate ligaseFunctional Class: MThe phylogenetic pattern of COG0771 is --T--qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001645 (Folylpolyglutamate synthetase) with a combined E-value of 9.7e-06. IPB001645A 114-138","Residues 4-147 are 71% similar to a (LIGASE CELL SYNTHETASE PEPTIDOGLYCAN SYNTHESIS) protein domain (PD001083) which is seen in O68388_STRPY.Residues 148-245 are 72% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS ENZYME) protein domain (PD212530) which is seen in Q9ZHB0_STRPN.Residues 265-447 are 27% similar to a (LIGASE CELL SYNTHESIS ALL) protein domain (PD039271) which is seen in O69554_MYCLE.Residues 257-450 are 25% similar to a (LIGASE PROTEOME COMPLETE) protein domain (PD269032) which is seen in Q9RRJ4_DEIRA.Residues 261-301 are 68% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN) protein domain (PD039273) which is seen in MURD_ENTHR.Residues 302-444 are 78% similar to a (LIGASE CELL) protein domain (PD039274) which is seen in Q9ZHB0_STRPN.Residues 250-301 are 57% similar to a (LIGASE CELL ATP-BINDING SYNTHESIS) protein domain (PD346653) which is seen in MURD_ENTFA.Residues 312-420 are 34% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS) protein domain (PD001216) which is seen in Q9JS92_CHLPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jul 27 09:22:11 2006","Mon Feb 25 11:25:02 2002","Thu Jul 27 09:22:11 2006","Thu Apr 4 08:59:35 2002","Mon Feb 25 11:25:02 2002","Mon Feb 25 11:25:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0498 is paralogously related (blast p-value < 1e-3) to SMu0549, a predicted D-Ala-D-Ala adding enzyme, and to SMu1577, a predicted murC protein.","Mon Feb 25 11:34:57 2002","Thu Jul 27 09:22:11 2006","pdb1E0DA Chain A, Udp-N-Acetylmuramoyl-L-Alanine:d-Glutamate ... 162 6e-041pdb3UAGA Chain A, Udp-N-Acetylmuramoyl-L-Alanine:d-Glutamate ... 160 3e-040","SMU.548","","Residues 48 to 301 (E-value = 4.8e-83) place SMu0498 in the Mur_ligase family which is described as Mur ligase family, catalytic domain (PF01225)Residues 310 to 387 (E-value = 2.7e-17) place SMu0498 in the Mur_ligase_C family which is described as Mur ligase family, glutamate ligase domain (PF02875)","Thu Jul 27 09:22:11 2006","24379029","","","Bertrand JA, Fanchon E, Martin L, Chantalat L, Auger G, Blanot D, van Heijenoort J, Dideberg O.\"Open\" structures of MurD: domain movements and structural similarities with folylpolyglutamate synthetase.J Mol Biol. 2000 Sep 1;301(5):1257-66.PMID: 10966819 Bertrand JA, Auger G, Martin L, Fanchon E, Blanot D, Le Beller D, van Heijenoort J, Dideberg O.Determination of the MurD mechanism through crystallographic analysis of enzyme complexes.J Mol Biol. 1999 Jun 11;289(3):579-90.PMID: 10356330 Gegnas LD, Waddell ST, Chabin RM, Reddy S, Wong KK.Inhibitors of the bacterial cell wall biosynthesis enzyme MurD.Bioorg Med Chem Lett. 1998 Jul 7;8(13):1643-8.PMID: 9873406 Massidda O, Anderluzzi D, Friedli L, Feger G.Unconventional organization of the division and cell wall gene cluster of Streptococcus pneumoniae.Microbiology. 1998 Nov;144 ( Pt 11):3069-78.PMID: 9846742","Mon Feb 25 11:34:57 2002","Thu Jul 27 09:22:11 2006","1","","","SMU.548","59" "SMu0499","511930","513015","1086","ATGGCAAAAAAGAAAATTATCTTTACAGGTGGTGGGACAGTCGGTCATGTTACTCTTAATTTACTCCTTATTCCCCGCTTTTTAAAAGATGGCTGGGAAGTGCACTATATTGGTGATAAACATGGCATTGAGCATGAACAAATTGAGCAGTCAGATTTTGATGTCATCTTTCATTCAATTGCAACAGGTAAACTGCGCCGTTACTTTTCTTTGAAAAATGTACTAGATGTTTTCAAGGTTGGTTGGGGTGTTCTGCAGTCTCTTACGATTATGGTGAAGGTTCGTCCACAAGTACTATTTTCTAAAGGTGGGTTTGTTTCAGTTCCTCCTGTTGTAGCCGCTAATCTTTTGAGAATCCCTGTTTTTGTTCATGAATCTGATTTATCAATGGGACTGGCTAACCGAATTGCTTATAAATTTGCCACTACCATGTACACAACGTTTGAACAGTCTGATAATTTGACTAAAACAAAACACGTTGGAGCTATTACTAAAGTTAATCAAACTATTTCTAGCAGTGATGATAATACAGAAATTAAAACGATTAAAGAATATTTTGATCCTCGTTTAAAAACTTTGCTGTTTATTGGAGGTTCAGCTGGAGCCAAAGTTTTCAATCAATTTATTTCTGATACACCAGAACTCACTAAGCATTATAATGTTATCAATATTTCTGGCGATAAAACATTAAATAATTTAAGCCAAAATCTTTATCGTGTAGATTACGTGACGGAAATGTATCAGCCCTTGATGGATTTAGCAGATGTTGTTATTACACGCGGTGGTTCCAACACCATCTTTGAGCTGCTTGCTATGGCAAAACTTCATATCATTGTGCCGTTAGGAAAAGAAGCTAGTCGTGGTGATCAGCTTGAAAATGCTGCTTATTTTGAGGAAAAAGGTTATGCCCAACAATTATCTGAAGAAAATCTAAACTTTGCAGAACTTGATAAAGTGATCAAAGATTTATTAGAAAATCAAACCGTTTATCAAGATAAAATGACTTCATCAAGTGAGATAAAGACTCCAAATGATTTTTACAATCTTTTGTTAACAGATATAACATCTAAGAGTAAAGGAAAATAA","7.40","1.18","40519","MAKKKIIFTGGGTVGHVTLNLLLIPRFLKDGWEVHYIGDKHGIEHEQIEQSDFDVIFHSIATGKLRRYFSLKNVLDVFKVGWGVLQSLTIMVKVRPQVLFSKGGFVSVPPVVAANLLRIPVFVHESDLSMGLANRIAYKFATTMYTTFEQSDNLTKTKHVGAITKVNQTISSSDDNTEIKTIKEYFDPRLKTLLFIGGSAGAKVFNQFISDTPELTKHYNVINISGDKTLNNLSQNLYRVDYVTEMYQPLMDLADVVITRGGSNTIFELLAMAKLHIIVPLGKEASRGDQLENAAYFEEKGYAQQLSEENLNFAELDKVIKDLLENQTVYQDKMTSSSEIKTPNDFYNLLLTDITSKSKGK","513012","For other 'mur' genes see SMu0549 (murF); SMu0653 (murN); SMu0654 (murM); SMu0883 (murB); SMu1529 (murE); SMu1566 (murI);SMu0498 (murD); SMu1577 (murC); SMu1304 (murC);SMu1386 (murA) and SMu1429 (murZ).","undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase","Cytoplasm, Membrane, Extracellular","Similarities in gapped BLAST to murG proteins. Residues 4-361 are 68% similar to gi15675423 from S.pyogenes. Residues 4-355 are 65% similar to gi15902648 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0476 (1e-151).","

InterPro
IPR004276
Domain

Glycosyl transferase, family 28
PF03033	$\"[6-146]T$	Glyco_transf_28

InterPro
IPR007235
Domain

Glycosyltransferase 28, C-terminal
PF04101	$\"[192-347]T$	Glyco_tran_28_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2000	$\"[4-184]T$	G3DSA:3.40.50.2000
PTHR21015	$\"[1-297]T$	PTHR21015
SSF53756	$\"[4-361]T$	SSF53756

","BeTs to 11 clades of COG0707COG name: UDP-glucuronosyltransferasesFunctional Class: MThe phylogenetic pattern of COG0707 is -----qvceBrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-86 are 77% similar to a (TRANSFERASE N-ACETYLGLUCOSAMINE) protein domain (PD006119) which is seen in MURG_STRPN.Residues 87-234 are 68% similar to a (TRANSFERASE PYROPHOSPHORYL-UNDECAPRENOL) protein domain (PD005948) which is seen in Q9FB02_STRPY.Residues 236-361 are 62% similar to a (MURG) protein domain (PD396853) which is seen in Q9FB02_STRPY.Residues 236-342 are 64% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD000190) which is seen in MURG_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 10:49:20 2006","Mon Feb 25 11:36:08 2002","Thu Sep 7 10:49:20 2006","Thu Apr 4 09:01:00 2002","","Mon Feb 25 11:36:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0499 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 11:40:29 2002","Thu Sep 7 10:49:20 2006","pdb1F0KA Chain A, The 1.9 Angstrom Crystal Structure Of E. Co... 78 1e-015pdb1F0KA Chain A, The 1.9 Angstrom Crystal Structure Of E. Co... 419 4e-118","SMU.549","","Residues 6 to 146 (E-value = 6.3e-37) place SMu0499 in the Glyco_transf_28 family which is described as Glycosyltransferase family 28 N-terminal domain (PF03033)Residues 192 to 347 (E-value = 1.1e-25) place SMu0499 in the Glyco_tran_28_C family which is described as Glycosyltransferase family 28 C-terminal domain (PF04101)","Thu Sep 7 10:49:20 2006","24379030","","","Ha S, Walker D, Shi Y, Walker S.The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycanbiosynthesis.Protein Sci. 2000 Jun;9(6):1045-52.PMID: 10892798Massidda O, Anderluzzi D, Friedli L, Feger G.Unconventional organization of the division and cell wall gene cluster of Streptococcus pneumoniae.Microbiology. 1998 Nov;144 ( Pt 11):3069-78.PMID: 9846742","","Mon Feb 25 11:43:28 2002","1","","","SMU.549","279" "SMu0500","513015","514139","1125","ATGGCGAAAGATAAAGATACAGAAAAGCAAGAAATTCCTTTGACAGAATGGCAGCAGCGCAATTTGGAATTTCTTAAGAAAAAACAAGAAGAAAAACGCGAAAAAGAAAAACTAAATGAAAAGAAAATGGCTGAAAAAAAGGCTCAGTTTCAAACTGATAAAGAAGCAGACAGTAAGGAAAGTGATAAGCAACCTTCAAGTTTATTTGATGATAAAAAACAAGAAGAGCCTAAAAAAAAGCCAGCTACACCTAAAAAGATAAAAAAAGAAAAGAAAGTGCCAAAACTTCCTCGAAAGGACTACTGGCAGGCTGCTATGGTTATTATCATTTCAAGCATTGTTTTAATTGCCTCCTTATTTATGATTAGTCCTTTGAGTCGTCAAAAGGAGATAACTGTTTCGGGTAATAAAAATGCCATTGAATCTCAGTTAATTGAAGAATTAGGGATTAAGAAATCAGATTATCTAACGACCTTACTTTTTCAGGCCAATCGTTTTGAAAGAAATCTTAAGTCTAAAGATAAATGGGTAAAGGAGGCAAAATTAGTTTATCATTTTCCTAATCATTTTACTTTAAGAGTAAAAGAATATCGTATTATTGCTTATAGACAAACGGATAAAGGCTATGTCCCAATTTTAGAAAATGGTACCCGTGTTGATACCGTTAACGCTTCAGAATTACCTGGTTCATTTGTGACTATTAATTTAGATCAGGAAAAAGAGGTTCGAGAACTGGTTCAAAAATTGGCAAAACTTGATAAATCCTTAGTTGGTAGTATTAAAGTCATTTCTTCTGTTAATTCCAGCTCTACTAAGGATCTGCTTTTATTGGAAATGAAAGATAACAACAGTGTTCGTGTTCCTTTATCAGAAATTGATACAAAATTACCTTATTATTCTAAAATTAAAAAGAATCTTACAGACGGCAGTATTGTTGATATGGAGGTGGGGATTTATAGTACAACTGCAGATATAGAAGCTTCGATTGCAGAACATAAGACAACAGCTACAACAGAATCTTCTGAGAACTCCTCTAATGCTGAAAATACTGATTCAACACAATCTTCAGAAGCAAATTCACAAGAAGGTTCACAATCAGTAACGCAGGCAACCGTATCTCAATAA","9.80","6.77","42503","MAKDKDTEKQEIPLTEWQQRNLEFLKKKQEEKREKEKLNEKKMAEKKAQFQTDKEADSKESDKQPSSLFDDKKQEEPKKKPATPKKIKKEKKVPKLPRKDYWQAAMVIIISSIVLIASLFMISPLSRQKEITVSGNKNAIESQLIEELGIKKSDYLTTLLFQANRFERNLKSKDKWVKEAKLVYHFPNHFTLRVKEYRIIAYRQTDKGYVPILENGTRVDTVNASELPGSFVTINLDQEKEVRELVQKLAKLDKSLVGSIKVISSVNSSSTKDLLLLEMKDNNSVRVPLSEIDTKLPYYSKIKKNLTDGSIVDMEVGIYSTTADIEASIAEHKTTATTESSENSSNAENTDSTQSSEANSQEGSQSVTQATVSQ","514136","For other 'fts' genes, see SMu0013 (ftsH); SMu0501 (ftsA);SMu0502 (ftsZ);SMu0650 (ftsW); SMu0676 (ftsY); SMu0411 (ftsL); SMu1209 (ftsX); SMu1210 (ftsE) and SMu1483 (ftsK). ","cell division protein","Extracellular, Periplasm, Membrane","Several matches in gapped BLAST to cell division protein:residues 1-366 are 41% similar to cell division protein in Streptococcus pyogenes M1 GAS (gi|15675422|).Residues 1-322 are 32% similar to the protein from S.pneumoniae (gi|15902649|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0477 (6e-55).","

InterPro
IPR005548
Family

Cell division protein FtsQ
PF03799	$\"[200-322]T$	FtsQ

InterPro
IPR013685
Domain

Polypeptide-transport-associated, FtsQ-type
PF08478	$\"[126-197]T$	POTRA_1

","BeTs to 3 clades of COG1589COG name: Cell division septal protein FtsQFunctional Class: MThe phylogenetic pattern of COG1589 is -------cebrh----ol--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 120-205 are 31% similar to a (DIVISION CELL FTSQ) protein domain (PD123055) which is seen in O07110_ENTFA.Residues 211-320 are 37% similar to a (DIVISION CELL DIVIB FTSQ) protein domain (PD011496) which is seen in Q9ZHA8_STRPN.Residues 123-202 are 33% similar to a (DIVISION CELL COMPLETE PROTEOME) protein domain (PD404458) which is seen in Q9CF93_LACLA.Residues 120-202 are 39% similar to a (DIVISION CELL DIVIB) protein domain (PD295931) which is seen in Q9ZHA8_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:30:30 2002","Wed Dec 5 08:20:32 2001","Tue Mar 19 08:02:03 2002","Wed Dec 5 08:13:33 2001","","Wed Dec 5 08:13:33 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0500 is paralogously related (blast p-value < 1e-3) to SMu1575, a predicted aminodeoxychorismate lyase-like protein (fragment).","Tue Mar 19 08:02:03 2002","","No significant hits to the NCBI PDB database.","SMU.550","","Residues 97 to 322 (E-value = 8.5e-46) place SMu0500 in the FtsQ family which is described as Cell division protein FtsQ (PF03799)","Wed Dec 5 08:13:33 2001","24379031","","","Massidda,O., Anderluzzi,D., Friedli,L. and Feger,G.Unconventional organization of the division and cell wall genecluster of Streptococcus pneumoniaeMicrobiology 144 (Pt 11), 3069-3078 (1998)PubMed: 9846742Pucci,M.J., Thanassi,J.A., Discotto,L.F., Kessler,R.E. andDougherty,T.J.Identification and characterization of cell wall-cell division gene clusters in pathogenic gram-positive cocciJ. Bacteriol. 179 (17), 5632-5635 (1997)PubMed: 9287029","Wed Dec 5 09:50:16 2001","Wed Dec 5 09:50:16 2001","1","","","SMU.550","649" "SMu0501","514291","515652","1362","ATGGCTAGAGATGGCTTTTTTACAGGATTGGATATAGGAACAAGCTCGATTAAAGTTTTAGTTGCTGAATTTATCAATGGCAGTATGAATGTTATTGGTGTTAGCAATGTCAAAAGTTCGGGTGTAAAAGACGGTATCATTATTGATATAGATACTGCGGCAGAAGCCATTAAATCAGCAATTAAAGAAGCAGAAGAAAAAGCAGGGATGTCAATCAGCAAGGTTAATGTTGGTCTACCGGCAAATCTGTTGCAAATTGAGCCAACACAGGGAATGATTCCTGTTCCTAGTGAATCTAAGGAAATCAAAGATGAAGATGTTGATAGTGTTGTTCGTTCAGCTTTAACAAAGAGCATCACACCAGAACGTGAAGTGATTTCACTTATTCCTGAAGAATTCATTGTGGATGGTTTCCAAGGTATTCGCGATCCTCGCGGAATGATGGGAATTCGTTTAGAAATGCGCGGTCTAATTTATACTGGACCAAGTACTATTTTGCATAATCTTCGTAAAACAGTAGAACGTGCAGGTATTGAAGTTGAAAATATTATTATTTCTCCACTGGCTCTTACCAAGTCAGTTTTGAATGAAGGAGAACGTGAGTTTGGAGCCACCGTTATTGATATGGGAGGCGGTCAAACCACAGTAGCTTCAATGCGAGCACAAGAATTGCAATTCACCAATACCTATGCCGAAGGTGGTGATTATGTTACTAAGGATATTTCTAAAGTCCTTAAAACATCCCACCAAGTGGCTGAGGCACTTAAGTTTAACTTTGGTGAAGCTAATGTAGCTGAAGCGAGTTCAACTGAAACTGTTCAGGTGGAAGTGGTGGGTGAACGTAATCCGGTTGAAATTACTGAACGCTACCTTTCCGAAATTATATCAGCGCGTGTTCGTCACTTGCTAGACCGTATTAAACAAGACTTAGAACGCGGTAGATTATTAGATCTGCCTGGTGGAATTGTTATTGTGGGTGGAGCTGCTATCATGCCTGGGGTTGTAGAAATCGCTCAAGAAATTTTTGGTTTCAATGTTAAACTTCATGTTCCAAACCAAGTCGGCATCAGAAATCCTATGTTTGCTAATATTATTAGCATTGTTGAATACGTAGGAACACTTACTGAAGTTGATATTTTAGCGCAAGGTGCGGTTTCTGGTGATGAAAAATTAAGAAGAAAACCAATTGATATTAAGCCATCAGGTGTTGCACCCAAAACTAGAAGTTTTGCTCAACCGCAAGAGTCGACTACTCTTGAATCACAATTGGAACAATTGCCGCCTCAACAGAAGGAAGCAAATGAGCCAAAACAAAAAGTGGGTGATCGTTTACGTGGTATCTTTGGTAGCATGTTCGACTAA","4.90","-12.98","49093","MARDGFFTGLDIGTSSIKVLVAEFINGSMNVIGVSNVKSSGVKDGIIIDIDTAAEAIKSAIKEAEEKAGMSISKVNVGLPANLLQIEPTQGMIPVPSESKEIKDEDVDSVVRSALTKSITPEREVISLIPEEFIVDGFQGIRDPRGMMGIRLEMRGLIYTGPSTILHNLRKTVERAGIEVENIIISPLALTKSVLNEGEREFGATVIDMGGGQTTVASMRAQELQFTNTYAEGGDYVTKDISKVLKTSHQVAEALKFNFGEANVAEASSTETVQVEVVGERNPVEITERYLSEIISARVRHLLDRIKQDLERGRLLDLPGGIVIVGGAAIMPGVVEIAQEIFGFNVKLHVPNQVGIRNPMFANIISIVEYVGTLTEVDILAQGAVSGDEKLRRKPIDIKPSGVAPKTRSFAQPQESTTLESQLEQLPPQQKEANEPKQKVGDRLRGIFGSMFD","515649","For other 'fts' genes, see SMu0013 (ftsH); SMu0502 (ftsZ);SMu0500 (ftsQ); SMu0650 (ftsW); SMu0676 (ftsY); SMu0411 (ftsL); SMu1209 (ftsX); SMu1210 (ftsE) and SMu1483 (ftsK). From Genbank:[gi:3122101]This protein may be involved in anomalous filament growth.It may be a component of the septum.","cell division protein FtsA","Membrane, Cytoplasm","Several matches in gapped BLAST to cell division protein:residues 1-453 are 79% similar to the cell division protein in Streptococcus pyogenes M1 GAS (gi|15675421|).Residues 1-453 are 67% similar to the protein from S.pneumoniae (gi|15901502|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0478 (1e-157).","

InterPro
IPR003494
Family

Cell division protein FtsA
PF02491	$\"[7-194]T$ $\"[204-367]T$	FtsA
TIGR01174	$\"[6-370]T$	ftsA

noIPR
unintegrated

unintegrated
SSF53067	$\"[4-195]T$ $\"[196-370]T$	SSF53067

","BeTs to 8 clades of COG0849COG name: Predicted ATPases of the HSP70 class involved in cell divisionFunctional Class: DThe phylogenetic pattern of COG0849 is -----qVceb-huj--ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB003494 (Cell division protein FtsA) with a combined E-value of 1.2e-11. IPB003494A 194-213 IPB003494B 320-329","Residues 173-262 are 77% similar to a (CELL DIVISION SHAPE COMPLETE) protein domain (PD005443) which is seen in Q9ZHC0_STRPN.Residues 274-367 are 57% similar to a (CELL DIVISION SHAPE PROTEOME) protein domain (PD040815) which is seen in Q9ZHC0_STRPN.Residues 1-171 are 69% similar to a (CELL DIVISION SHAPE COMPLETE) protein domain (PD335813) which is seen in Q9ZHC0_STRPN.Residues 369-453 are 35% similar to a (DIVISION CELL FTSA) protein domain (PD216448) which is seen in Q9ZHC0_STRPN.Residues 283-368 are 46% similar to a (CELL DIVISION FTSA PROTEOME) protein domain (PD414398) which is seen in FTSA_ENTHR.Residues 173-262 are 32% similar to a (CELL UTILIZATION DIVISION ETHANOLAMINE) protein domain (PD407875) which is seen in Q9RWN6_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:30:59 2002","Wed Dec 5 09:53:06 2001","Tue Mar 19 08:02:50 2002","Wed Dec 5 08:25:11 2001","Wed Dec 5 08:25:11 2001","Wed Dec 5 08:25:11 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0501 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 09:46:33 2002","","No significant hits to the NCBI PDB database.","SMU.551","","Residues 7 to 195 (E-value = 1.1e-59) place SMu0501 in the FtsA family which is described as Cell division protein FtsA (PF02491)Residues 197 to 377 (E-value = 1.2e-43) place SMu0501 in the FtsA family which is described as Cell division protein FtsA (PF02491)","Wed Dec 5 08:25:11 2001","24379032","","","Massidda,O., Anderluzzi,D., Friedli,L. and Feger,G.Unconventional organization of the division and cell wall genecluster of Streptococcus pneumoniaeMicrobiology 144 (Pt 11), 3069-3078 (1998)PubMed: 9846742Pucci,M.J., Thanassi,J.A., Discotto,L.F., Kessler,R.E. andDougherty,T.J.Identification and characterization of cell wall-cell division gene clusters in pathogenic gram-positive cocciJ. Bacteriol. 179 (17), 5632-5635 (1997)PubMed: 9287029Beall,B., Lowe,M. and Lutkenhaus,J.Cloning and characterization of Bacillus subtilis homologs ofEscherichia coli cell division genes ftsZ and ftsAJ. Bacteriol. 170 (10), 4855-4864 (1988)PubMed: 3139638Gonzy-Treboul,G., Karmazyn-Campelli,C. and Stragier,P.Developmental regulation of transcription of the Bacillus subtilisftsAZ operonJ. Mol. Biol. 224 (4), 967-979 (1992)PubMed: 1569582Gholamhoseinian,A., Shen,Z., Wu,J.J. and Piggot,P.Regulation of transcription of the cell division gene ftsA duringsporulation of Bacillus subtilisJ. Bacteriol. 174 (14), 4647-4656 (1992)PubMed: 1624452","Wed Dec 5 09:55:31 2001","Wed Dec 5 09:55:31 2001","1","","","SMU.551","280" "SMu0502","515676","516980","1305","ATGGCATTTTCATTTGATGCAGCATCTGTACAAGGTGCAGTAATTAAAGTTATTGGAGTCGGTGGTGGCGGCGGTAACGCTATTAACCGTATGATTGATGAAGGTGTTGCAGGTGTTGAATTCATTGCTGCTAACACTGATATTCAAGCTTTGAGTAGTTCTAAAGCTGAAACAGTTATTCAACTTGGACCTAAATTAACCCGTGGTCTTGGTGCAGGAGGCCAACCTGAAATTGGACGTAAAGCTGCTGAAGAAAGCGAAGAAGCTTTGACAGAAGCACTTACTGGAGCTGATATGGTTTTTATTACTGCTGGTATGGGTGGTGGTTCTGGTACGGGAGCCGCTCCAGTTATTGCTCGAATTGCTAAGGGTTTAGGTTCATTGACAGTTGCTGTCGTCACTCGACCATTTGGTTTTGAAGGCAGTAAACGTGGCAATTATGCAATTGAAGGTATCAATGAACTTAGAGATGAAGTTGATACGCTCCTTATTATTTCAAATAATAATCTACTTGAAATTGTTGACAAGAAAACACCGCTTCTTGAAGCACTCAGTGAAGCTGATAATGTTCTTCGCCAAGGTGTTCAGGGGATTACCGACCTGATTACAAGTCCAGGACTTATTAATCTTGACTTTGCTGATGTTAAAACAGTTATGGCAAGTAAAGGAAATGCTCTGATGGGAATCGGTATCGGTACTGGTGAAGAACGTGTTGTTGAGGCTGCTCGCAAGGCGATCTATTCACCACTTCTTGAGACGACAATTGATGGTGCAGAAGATGTGATTGTCAATGTTACCGGCGGCCTTGATATGACGCTGACAGAAGCTGAAGAGGCTTCTGAAATTGTTAATCAAGCTGCAGGTCATGGCGTTAACATTTGGTTGGGAACATCAATTGATGACAGTATGAAAGATGAAATTCGTGTGACTGTAGTTGCCACTGGTGTTCGGCCAGACAAAGCTGACCAAGTCTCTGGTATTCGCCGTCAAGCTTCATCTTATACACAACCAAGAGCACAACAGCAAGCTCCGTCTTCAAATTCTGCGCAGCCAAATTTTGAACGCCGTCAAAATTTTGATTTTGATTTGAATGAATCACCTGAGATGCCTGCTGCTGAACCGCAGCAAACTCAATCATCATCTGAGCCACAGCAATCAGCTTTTGGCGATTGGAATCTTCGTCGTGAAAATATTGCTCGTCCAACCGAAGGTGAAATTGATAGTCAACTAAAAATGAGTAGTTTTTCCGCTGATTCTGATGATGACGATGAGTTGGAAACACCTCCTTTCTTTAAGAATCGTTAA","4.20","-27.70","45732","MAFSFDAASVQGAVIKVIGVGGGGGNAINRMIDEGVAGVEFIAANTDIQALSSSKAETVIQLGPKLTRGLGAGGQPEIGRKAAEESEEALTEALTGADMVFITAGMGGGSGTGAAPVIARIAKGLGSLTVAVVTRPFGFEGSKRGNYAIEGINELRDEVDTLLIISNNNLLEIVDKKTPLLEALSEADNVLRQGVQGITDLITSPGLINLDFADVKTVMASKGNALMGIGIGTGEERVVEAARKAIYSPLLETTIDGAEDVIVNVTGGLDMTLTEAEEASEIVNQAAGHGVNIWLGTSIDDSMKDEIRVTVVATGVRPDKADQVSGIRRQASSYTQPRAQQQAPSSNSAQPNFERRQNFDFDLNESPEMPAAEPQQTQSSSEPQQSAFGDWNLRRENIARPTEGEIDSQLKMSSFSADSDDDDELETPPFFKNR","516977","For other 'fts' genes, see SMu0013 (ftsH); SMu0501 (ftsA); SMu0500 (ftsQ); SMu0650 (ftsW); SMu0676 (ftsY); SMu0411 (ftsL); SMu1209 (ftsX); SMu1210 (ftsE) and SMu1483 (ftsK). From Genbank:[gi:3287842]This protein is essential to the cell-division process.It seems toassemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur,and the formation of the ring is the signal for septation to begin.It binds to and hydrolyzes GTP. ","cell division protein FtsZ","Cytoplasm","Several matches in gapped BLAST to cell division proteins:residues 1-434 are 82% similar to the cell division protein in Streptococcus pyogenes (gi|15675420|).Residues 1-434 are 76% similar to the protein from S.pneumoniae (gi|15901501|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0479 (1e-147).","

InterPro
IPR000158
Family

Cell division protein FtsZ
PR00423	$\"[61-79]T$ $\"[99-119]T$ $\"[127-148]T$ $\"[190-212]T$ $\"[213-234]T$ $\"[257-275]T$	CELLDVISFTSZ
TIGR00065	$\"[1-346]T$	ftsZ
PS01134	$\"[45-79]T$	FTSZ_1

InterPro
IPR003008
Domain

Tubulin/FtsZ, GTPase
PF00091	$\"[13-206]T$	Tubulin

InterPro
IPR008280
Domain

Tubulin/FtsZ, C-terminal
PF03953	$\"[208-333]T$	Tubulin_C

noIPR
unintegrated

unintegrated
G3DSA:3.30.1330.20	$\"[226-332]T$	G3DSA:3.30.1330.20
G3DSA:3.40.50.1440	$\"[2-221]T$	G3DSA:3.40.50.1440
SSF52490	$\"[12-209]T$	SSF52490
SSF55307	$\"[208-332]T$	SSF55307

","BeTs to 15 clades of COG0206COG name: Cell division GTPase FtsZFunctional Class: DThe phylogenetic pattern of COG0206 is AMtK-qvcebrhujgpol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB000158 (Cell division protein FtsZ) with a combined E-value of 8.9e-123. IPB000158A 27-78 IPB000158B 96-141 IPB000158C 187-238 IPB000158D 247-275","Residues 31-317 are 77% similar to a (DIVISION CELL GTP-BINDING SEPTATION HOMOLOG PROTEOME) protein domain (PD001349) which is seen in Q9ZHB9_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:31:22 2002","Wed Dec 5 08:49:22 2001","Tue Mar 19 08:04:48 2002","Wed Dec 5 08:39:13 2001","Wed Dec 5 08:39:13 2001","Wed Dec 5 08:39:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0502 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 19 08:04:48 2002","Wed Dec 5 08:39:13 2001","pdb|1FSZ| Crystal Structure Of The Cell-Division Protein Fts... 205 9e-054","SMU.552","","Residues 13 to 206 (E-value = 1.5e-89) place SMu0502 in the Tubulin family which is described as Tubulin/FtsZ family, GTPase domain (PF00091)Residues 208 to 333 (E-value = 3.6e-24) place SMu0502 in the Tubulin_C family which is described as Tubulin/FtsZ family, C-terminal domain (PF03953)","Wed Dec 5 08:39:13 2001","24379033","","","Massidda,O., Anderluzzi,D., Friedli,L. and Feger,G.Unconventional organization of the division and cell wall genecluster of Streptococcus pneumoniaeMicrobiology 144 (Pt 11), 3069-3078 (1998)PubMed: 9846742Duez,C., Thamm,I., Sapunaric,F., Coyette,J. and Ghuysen,J.M.The division and cell wall gene cluster of Enterococcus hirae S185DNA Seq. 9 (3), 149-161 (1998)PubMed: 10520745Beall,B., Lowe,M. and Lutkenhaus,J.Cloning and characterization of Bacillus subtilis homologs ofEscherichia coli cell division genes ftsZ and ftsAJ. Bacteriol. 170 (10), 4855-4864 (1988)PubMed: 3139638","Wed Dec 5 09:58:57 2001","Wed Dec 5 09:58:57 2001","1","","","SMU.552","60" "SMu0503","516983","517654","672","ATGGATTTACAAGCAAATAAAGAACACGTTTTTCAAGAAGTTGCAGCCTATGCTCAAAAGTCAGGGCGCAGTAAGGACGATGTTACTGTTATTGCAGTTACAAAATATGTAGACAGTGATACAGCTGAAAAACTTGTTGAAGCTGGGGTTAAGCACATTGCTGAAAATCGTGTTGATAAGTTCCTAGATAAATATCGTGCTTTAAAATCTTACGATTTAACTTGGCATCTGATTGGAAGTTTGCAGCGTCGTAAGGTTAAGGATGTGATTAATTTTGTTGACTACTTCCATGCTCTTGATTCTGTAAAATTAGCTGCTGAAATTCAAAAGCGTGCAGACCATCAAATAAAGTGTTTTTTACAAGTCAATATATCTGAAGAAGCAAGTAAACATGGATTCAGACTATCAGAAGTTGACAAGGCGCTTGAAGAAATTCAGCATTTTGATAAGATTAAAGTTATCGGTTTAATGACGATGGCTCCAATAGATGCTTCCGAACAAGAGTTAACTGATATTTTTCAAAAAGCAAATGCGTTGAGAAAGAACTTAAAAGAAAGAAAACTGAAGAATATGCCGTTCGATGATTTGAGTATGGGGATGAGTGGCGATTTTCCGATTGCTATTCGAAATGGCTCAACCTTTGTCAGAATTGGCAGTGCATTCTTTAAATGA","9.00","3.64","25395","MDLQANKEHVFQEVAAYAQKSGRSKDDVTVIAVTKYVDSDTAEKLVEAGVKHIAENRVDKFLDKYRALKSYDLTWHLIGSLQRRKVKDVINFVDYFHALDSVKLAAEIQKRADHQIKCFLQVNISEEASKHGFRLSEVDKALEEIQHFDKIKVIGLMTMAPIDASEQELTDIFQKANALRKNLKERKLKNMPFDDLSMGMSGDFPIAIRNGSTFVRIGSAFFK","517651","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-222 are 63% similar to S.pyogenes (gi|15675419|) and 60% similar to S.pneumoniae (gi|15903552|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0480 (2e-75).","

InterPro
IPR001608
Domain

Alanine racemase, N-terminal
PF01168	$\"[9-223]T$	Ala_racemase_N

InterPro
IPR011078
Family

Predicted pyridoxal 5'-phosphate-dependent enzyme, YBL036C type
PTHR10146	$\"[1-223]T$	PP_YBL036C
TIGR00044	$\"[1-223]T$	PP_YBL036C

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.10	$\"[3-222]T$	G3DSA:3.20.20.10
PIRSF004848	$\"[5-223]T$	YBL036c_PLPDEIII
SSF51419	$\"[1-223]T$	SSF51419

","BeTs to 8 clades of COG0325COG name: Predicted enzyme with a TIM-barrel foldFunctional Class: RThe phylogenetic pattern of COG0325 is ----yqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001608 (Uncharacterized pyridoxal-5'-phosphate dependent enzyme family UPF0001) with a combined E-value of 1.7e-57. IPB001608A 30-64 IPB001608B 75-85 IPB001608C 97-109 IPB001608D 120-133 IPB001608E 149-159 IPB001608F 196-223","Residues 28-222 are 63% similar to a (PROTEOME COMPLETE SYNTHETASE PROLINE YLME ASSOCIATED) protein domain (PD004988) which is seen in Q9ZHB8_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 09:49:48 2002","Wed Dec 5 09:02:58 2001","Mon Jan 14 09:49:48 2002","Wed Dec 5 09:02:58 2001","Mon Jan 14 09:49:48 2002","Wed Dec 5 09:02:58 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0503 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 09:49:48 2002","Wed Dec 5 09:02:58 2001","pdb|1B54| Crystal Structure Of A Yeast Hypothetical Protein -... 77 2e-015pdb|1CT5|A Chain A, Crystal Structure Of Yeast Hypothetical Pro... 70 2e-013pdb|1B54| Crystal Structure Of A Yeast Hypothetical Protein -... 295 2e-081","SMU.553","","Residues 15 to 223 (E-value = 2.3e-12) place SMu0503 in the Ala_racemase_N family which is described as Alanine racemase, N-terminal domain (PF01168)","Wed Dec 5 09:02:58 2001","24379034","","","","","","1","","","SMU.553","650" "SMu0504","517668","518243","576","ATGGCACTTAGAGACAGCTTTAACAAAATTATTTCCTACTTCGATACTGATGAGGTCAGTGAAGTAGAAGAGCCTGCTGTTGCGTCTGTTAAACGGCAGCAAGATGCAGCTCAACCTGCTAGTCAGCAGCAAAAAGCTCAAAGTCACCAATACCACCAATCAGCCTCCAGACCAAGTCAGCAGCAAGTACAGTCTGGACAGAATCGTCGTTCTGGAGAGGAAAATATTCATTCACTTCCAACACGTCGCCAATCTCATAATCAACAGCCTGCCCAAGAAAAGACAACAATCGCTCTTAAGCTTCCTCGTAAATATGAAGATGCTGAAGAGATTGTTGATTTGCTGATTAGAAATGAATGTGTTTTGATTGATTTCCAATATATGTTGGAAGCACAAGCACGTCGTTGCTTAGATTTTATTGATGGTGCGAGTAAAGTCTTAGCAGGAAACTTGCAAAAGGTTGGGGCTTCAATGTATCTTTTAACGCCAATTAATGTTATTGTTGATGCTGAGGAAATGACTCTTGCTGCAAATGGACAAGATGTTAGTTTTAACTATGATATGAAGAGACGTTAA","5.70","-3.13","21625","MALRDSFNKIISYFDTDEVSEVEEPAVASVKRQQDAAQPASQQQKAQSHQYHQSASRPSQQQVQSGQNRRSGEENIHSLPTRRQSHNQQPAQEKTTIALKLPRKYEDAEEIVDLLIRNECVLIDFQYMLEAQARRCLDFIDGASKVLAGNLQKVGASMYLLTPINVIVDAEEMTLAANGQDVSFNYDMKRR","518240","","conserved hypothetical protein","Cytoplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 1-191 are 51% similar to S.pyogenes (gi|15675418|) and 45% similar to S.pneumoniae (gi|15903551|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0481 (4e-44).","

InterPro
IPR007561
Family

Protein of unknown function DUF552
PF04472	$\"[92-171]T$	DUF552

noIPR
unintegrated

unintegrated
PD312742	$\"[97-168]T$	PD312742

","BeTs to 3 clades of COG1799COG name: Uncharacterized BCR, YlmF familyFunctional Class: SThe phylogenetic pattern of COG1799 is -------c-br----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 102-173 are 72% similar to a (PROTEOME COMPLETE YLMF YAK) protein domain (PD312742) which is seen in Q9ZHB7_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 09:50:51 2002","Wed Dec 5 09:09:51 2001","Mon Jan 14 09:50:51 2002","Wed Dec 5 09:09:51 2001","","Wed Dec 5 09:09:51 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0504 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 09:50:51 2002","","No significant hits to the NCBI PDB database.","SMU.554","","Residues 92 to 171 (E-value = 4.3e-40) place SMu0504 in the DUF552 family which is described as Protein of unknown function (DUF552) (PF04472)","Wed Dec 5 09:09:51 2001","24379035","","","","","","1","","","SMU.554","778" "SMu0505","518243","518503","261","ATGGTTATGACATATGTTGTGCTTATTCTAGCAAGAGTAGTTGATATTTATTCCTTTTTGCTAGTAATTTATGCTCTCTTGTCTTGGTTTCCTAATGCTTATGATACTTGGCTTGGAAAACTTTTGGTTGATATTGTGGAGCCAATTATAAAGCCTTTTAGACGTTTTGATTTTCAATTTGCTGGATTAGATTTTAAGATTATTGTTATTCTTTTGCTTTTGCAGTTATTAAAACGATTCTTATTTCTTTTGCTTATTTAA","10.00","1.98","10178","MVMTYVVLILARVVDIYSFLLVIYALLSWFPNAYDTWLGKLLVDIVEPIIKPFRRFDFQFAGLDFKIIVILLLLQLLKRFLFLLLI","518500","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 3-86 are 50% similar to S.pyogenes (gi|15675417|) and 38% similar to S.pneumoniae (gi|15901498|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0482 (3e-20).","

InterPro
IPR003425
Family

Protein of unknown function YGGT
PF02325	$\"[3-84]T$	YGGT

","BeTs to 6 clades of COG0762COG name: Predicted integral membrane protein, YggT familyFunctional Class: SThe phylogenetic pattern of COG0762 is ------vCeb-huj--olin-Number of proteins in this genome belonging to this COG is 1","***** IPB003425 (YGGT family) with a combined E-value of 5.2e-09. IPB003425A 10-27 IPB003425B 44-74","Residues 10-64 are 47% similar to a (COMPLETE PROTEOME TRANSMEMBRANE INTEGRAL CHLOROPLAST) protein domain (PD005585) which is seen in Q9ZAI8_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 09:51:57 2002","Wed Dec 5 10:17:02 2001","Mon Jan 14 09:51:57 2002","Wed Dec 5 09:11:31 2001","Wed Dec 5 09:11:31 2001","Wed Dec 5 09:11:31 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0505 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 09:51:57 2002","","No significant hits to the NCBI PDB database.","SMU.555","","Residues 3 to 84 (E-value = 1.8e-21) place SMu0505 in the YGGT family which is described as YGGT family (PF02325)","Wed Dec 5 09:11:31 2001","24379036","","","","","","1","","","SMU.555","1009" "SMu0506","518507","519298","792","ATGATGACAAAGCAAGATATTTACCAACATTTTAGAGCAGAAGAGCAGGAAGTAATTGAAAAAACGTATGATCTGATCAAACAGGTAGAGGATACTTATAGCTTTTGTGTCACAGAATTCTTAAATCCTAGACAGATTACAGTGATGAAAAGTATCTTAGGTCAAACAAAACTACAGGTTTATCAGAGTTCTGATTTTATCTCTTCTGAAAATGCTCGTTTGTTAATAGCACCAGCTTATTATGAGTTAAATATAGCAGACTTTCATATTAGTTTGTTAGAGATTAACTATAATAGTAAGTTTAATCAGCTAACACATTCTCAGATTTTGGGAACCCTGATTAATAGATTGGGTATTGAACGTTATCTTTTAGGTGATATTATTGTTCAAGAAAATCGTGCTCAGGTTTTTATCGAAAAAACAATGGTCTCCTACCTTAACGCACAGGTTACTAAAATAGGAAAAGCCACAGTTGTTTTTGAAGAAATTCCTTTTGAAAGACAAATAACAAGCCAATCTCATATTAAAGAAATGAATGTCTTGGTATCAAGTATGCGTTTGGATAAAATTATTGCAGCCGTTTTAAAATTATCAAGAAGAAAAGCAAATCAATTAATTGAAAGCGAAAAAGTCAAATTAAATTACTTAGTTCAACCAAAAGTCTCTCAATTGATTGACATTGGTGATTTAATTAGTGTTAGAGGTTATGGCAGATTTACTATCAGTAGAGACAACGGCCTTTCAAAAGGCGGAAAGCATAAATTAATAATTGATCGAATCACACATAAATAA","9.90","6.40","30303","MMTKQDIYQHFRAEEQEVIEKTYDLIKQVEDTYSFCVTEFLNPRQITVMKSILGQTKLQVYQSSDFISSENARLLIAPAYYELNIADFHISLLEINYNSKFNQLTHSQILGTLINRLGIERYLLGDIIVQENRAQVFIEKTMVSYLNAQVTKIGKATVVFEEIPFERQITSQSHIKEMNVLVSSMRLDKIIAAVLKLSRRKANQLIESEKVKLNYLVQPKVSQLIDIGDLISVRGYGRFTISRDNGLSKGGKHKLIIDRITHK","519295","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 1-263 are 46% similar to S.pyogenes (gi|15675416|) and 44% similar to S.pneumoniae (gi|15901497|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0483 (1e-72).","

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[185-231]T$	S4
SM00363	$\"[185-256]T$	S4
PS50889	$\"[185-245]T$	S4

noIPR
unintegrated

unintegrated
SSF55174	$\"[184-241]T$	SSF55174

","BeTs to 3 clades of COG1187COG name: Predicted pseudouridylate synthase family 1Functional Class: JThe phylogenetic pattern of COG1187 is -----QvCEBrHuj--olinxNumber of proteins in this genome belonging to this COG is 3","***** IPB000748 (Pseudouridine synthase, Rsu family) with a combined E-value of 9.2e-07. IPB000748A 186-211","Residues 37-255 are 44% similar to a (PROTEOME COMPLETE YLMH BH2547) protein domain (PD039232) which is seen in Q9ZHB5_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 09:53:04 2002","Wed Dec 5 10:23:37 2001","Mon Jan 14 09:53:04 2002","Wed Dec 5 10:23:37 2001","Wed Dec 5 10:23:37 2001","Wed Dec 5 10:23:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0506 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 09:53:04 2002","","No significant hits to the NCBI PDB database.","SMU.556","","Residues 185 to 231 (E-value = 6.5e-08) place SMu0506 in the S4 family which is described as S4 domain (PF01479)","Wed Dec 5 10:23:37 2001","24379037","","","","","","1","","","SMU.556","779" "SMu0507","519309","520124","816","ATGGCAATTACAGCACTTGAAATTAAAGATAAAACATTTGGGACAAAAATGTTTGGTTACAATACTCAGGAAGTGGAAGAATTCTTGGATATTGTAGTTGATGACTATGAAGAGTTGGTACGTACTAATCGTGAGAAAGATAATCGTATCAAAGAGTTGGAAGATAAATTGGGCTATTTTGATGAAATGAAAGAATCTCTTAGTCAATCGGTTATTTTGGCTCAAGAAACAGCTGAAAAAGTGAAATTATCAGCCAATACTGAATCAACTAACATTCTTAACAAAGCCACTTATGAGTCGCAACAATTAGTTGATGCAGCTAAATCAAAAGCTAATCAGATTCTTCGCGATGCAACAGATGAAGCTAAACGTATTGCAGTTGAAACAGAAGAATTAAAGCGTCAAAGTCGTGTCTTCCATCAACACCTTTTATCTGTAGTAGAAGGTCAGTTAACACTTGCAAATTCTCCTGAATGGACAGAGTTACTTCAACCAACTGCTGTTTATTTACAGAATTCAGATGCTGCTTTCAAAGAAGTCGTAGAGCAAGTTTTAGGTGAACATGTTCCAGATGCTGCTGATACTGAACCTATTGAGGTGACACGTCAATTTACTCCAGAGGAAATGGAAGAATTGCATCGTCGTGTTTCTGAAAGTAATAAAGAACTGGAAGAGACAAAAGCTGGTCAGTCTACAGTTGATGATCAACAGCCTCTTATTATCGAGGCAGCTGATGAAACAAAAGTAAATGAGTCAGCGGATGAGCAACCAAATTTGAATGAAACACAGACTTTTAAATTAAATATTAACGAATAA","4.30","-27.98","30808","MAITALEIKDKTFGTKMFGYNTQEVEEFLDIVVDDYEELVRTNREKDNRIKELEDKLGYFDEMKESLSQSVILAQETAEKVKLSANTESTNILNKATYESQQLVDAAKSKANQILRDATDEAKRIAVETEELKRQSRVFHQHLLSVVEGQLTLANSPEWTELLQPTAVYLQNSDAAFKEVVEQVLGEHVPDAADTEPIEVTRQFTPEEMEELHRRVSESNKELEETKAGQSTVDDQQPLIIEAADETKVNESADEQPNLNETQTFKLNINE","520121","","cell division initiation protein","Cytoplasm","Several matches in gapped BLAST to cell-division initiation proteins: residues 1-269 are 63% similar to the cell-division initiation protein in S.pyogenes (gi|15675415|). Residues 1-228 are 58% to the protein from S.pneumoniae (gi|15901496|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0484 (6e-90).","

InterPro
IPR007793
Family

DivIVA
PF05103	$\"[1-269]T$	DivIVA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 85-163 are 53% similar to a (COMPLETE PROTEOME DIVIVA DIVISION) protein domain (PD034740) which is seen in Q9ZHB4_STRPN.Residues 164-246 are 46% similar to a (DIVISION CELL DIVIVA) protein domain (PD206084) which is seen in Q9ZHB4_STRPN.Residues 4-77 are 66% similar to a (PROTEOME COMPLETE DIVIVA CELL) protein domain (PD348262) which is seen in Q9ZHB4_STRPN.Residues 33-237 are 23% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in MYH8_HUMAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 10:02:34 2002","Thu Dec 6 08:05:05 2001","Tue Mar 19 08:07:10 2002","Wed Dec 5 10:29:14 2001","","Wed Dec 5 10:29:14 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0507 is paralogously related (blast p-value < 1e-3) to SMu0427 and SMu1152, both predicted conserved hypothetical proteins.","Tue Mar 19 08:07:43 2002","","No significant hits to the NCBI PDB database.","SMU.557","","Residues 1 to 269 (E-value = 1.6e-78) place SMu0507 in the DivIVA family which is described as DivIVA protein (PF05103)","Wed Dec 5 10:29:14 2001","24379038","","","Massidda,O., Anderluzzi,D., Friedli,L. and Feger,G.Unconventional organization of the division and cell wall genecluster of Streptococcus pneumoniaeMicrobiology 144 (Pt 11), 3069-3078 (1998)PubMed: 9846742","","Wed Dec 5 10:35:31 2001","1","","","SMU.557","534" "SMu0508","520634","523426","2793","ATGAAATTAAAAGAAACGCTTAATCTCGGAAAAACAGCATTCCCAATGCGTGCAGGCCTTCCTAATAAAGAACCACAATGGCAAAAACAGTGGGATGAAGCTAATATTTATGCTAAACGTCAAGAATTAAATGCAAATAAACCAGCTTTTTTCCTGCATGATGGGCCACCCTATGCCAATGGAAATATCCATGTAGGACATGCTCTTAATAAAATTTCAAAGGATATTATTATTCGTTCCAAATCAATGTCTGGTTTTCGAGCACCTTATATTCCGGGTTGGGATACACACGGTTTACCTATTGAACAAGTCCTTGCTAAAAAGGGTGTTAAACGTAAAGAAATTGACTTAGCAGACTATTTAGACATGTGTCGTCAGTATGCTTTGAGTCAAGTTGATAAGCAGCGTCAGGACTTTAAACGCTTAGGTGTTTCAGGAGATTGGGAGAATCCTTATATCACACTTGTTCCTAAGTATGAAGCTGCTCAAATTCGTGTCTTTGGTGCTATGGCTGACAAAGGCTATATTTATCATGGAGCTAAACCGGTTTATTGGTCTTGGTCTTCTGAATCAGCTCTTGCAGAAGCAGAGATTGAGTATCATGATATTGATTCAACTTCTCTTTACTATGCTAATCGTGTTAAAGATGGTAAAGATATTCTAGATACAGATACTTATATTGTTGTCTGGACAACAACACCATTTACCATTACAGCTTCTCGTGGTTTGACGGTCGGTCCGGATATAGATTATGTAGTTGTTAAACCAGCTAATGACGAACGTAAATTTCTCGTAGCACAAGCTCTTCTTTCAGAATTAGCAGAACGTTTTGCTTGGGACAACCCTCAGGTATTAGCAACTCATAAAGGTATTGAGCTCGACCGAATTGTGACAATTCATCCATGGGATGATAATGTAGAAGAATTAGTCATGAATGGGGATCATGTTACCCTTGATTCTGGTACGGGGATTGTTCATACAGCACCGGGATTTGGTGAGGATGACTATAATGTGGGAGTCAAATATGGTTTAGATGTTGTTGTTACTGTCAACGAACGTGGTATCATGATGGAAAATGCCGGTCCTGATTTTGAAGGACAATTCTATGACAAAGTTTTGCCAACAGTGAAAGAAAAGTTGGGTGATTTGCTTTTAGCATCAGAAGTTATCACGCATTCTTATCCTTTTGACTGGCGAACAAAAAAACCAATTATTTGGCGTGCAGTCCCACAATGGTTTGCCTCTGTTTCAAAATTCCGTCAAGATATTCTTGATGAAATTGATAAGGTTCATTTTTATCCTGCTTGGGGTAAAACGAGACTTTATAATATGATTCGTGATCGTGGCGATTGGGTTATTTCACGCCAACGTGCTTGGGGTGTTCCGCTTCCAATTTTCTACGCAGAAGATGGCACTGCCATTATGACTAAAGAAGTGACAGACCATATTGCCAATTTGTTTGAAGAACACGGCTCAGTCATTTGGTGGCAACGTGAGGCCAAAGATCTTCTCCCTGAAGGTTTTACTCATCCAGGTTCTCCAAATGGTGAATTTACTAAAGAAAATGATATTATGGATGTTTGGTTTGATTCGGGATCATCTTGGAATGGTGTTCTAAATACACGTGAAGACTTAGGCTATCCTGCAGACCTCTATCTTGAAGGCTCTGATCAATATCGTGGTTGGTTCAATTCATCACTGATCACTTCTGTAGCTGTTAACGGTCATGCGCCTTATAAATCCGTCTTGTCTCAAGGTTTTGTTCTGGATGGCAAGGGTGAGAAGATGTCTAAATCAAAAGGAAACATTATTTCGCCAAATGATGTTGCCAAACAATATGGTGCTGAAATTCTTCGCCTTTGGGTAGCTTCTGTCGACACCGATAGTGATGTTCGTGTATCTATGGAAATTTTAGGTCAGGTTTCGGAAACTTATCGTAAAATCCGTAATACCCTTCGCTTTTTGATTGCTAATACCACTGATTTTAATCCTTATATTAATAAGATTGCCTTTGAGGATCTTCGTTCTGTTGATAAATATATGTTAATCAAATTTAATCAGTTAGTTTCAGTAATTAATCGGGCTTACAGCCATTATGATTTCATGACTATCTATAAGGCTGTTGTTAATTTTGTGACTGTTGATTTATCAGCATTTTACCTCGATTTTGCTAAAGATGTTGTTTATATTGAAGCAGCAGACGATTTAGCTCGTCGTCAAATGCAAACGGTCTTTTACGAAATCTTGGTAAATATTACTAAGCTATTGACGCCGATTTTACCGCATACGAGTGAAGAAATTTGGTCTTATTTAGAGCATGAAGAAGAAGCATTTGTACAGTTAGCAGAAATGCCTGAAGCGCAAGAATTTGCCAACCAAGACGAAATTTTGGATACATGGAGTGCTTTTATGTCTCTGCGTGATCAAGCACAAAAAGCACTTGAAGAAGCTCGTAATGCTAAAATTATTGGTAAATCATTAGAAGCTCATTTGACTGTCTATGCTAGTGAAGAAGTTAAAACGCTTCTGACTGCTCTTGATAGCAACATTGCCCAACTGCTTATTGTGTCACAATTGACAGTGACTCAAGAACAAGCACCGAAAAATGCACTTGTCTTTGAAGATGTAGCCTTTAGTGTGGAACATGCTCGGGGGCATGTTTGTGACCGTTGTCGTCGCATTGATGAAACTGTCAAAGAACGTCCTTATCATGTTACAATTTGTAATCATTGTGCAGCTATTGTAGAAAATCATTTCCCTGAAGCTGTTAGGCAAGGATTTGAAAGCAAATAA","5.20","-28.10","105849","MKLKETLNLGKTAFPMRAGLPNKEPQWQKQWDEANIYAKRQELNANKPAFFLHDGPPYANGNIHVGHALNKISKDIIIRSKSMSGFRAPYIPGWDTHGLPIEQVLAKKGVKRKEIDLADYLDMCRQYALSQVDKQRQDFKRLGVSGDWENPYITLVPKYEAAQIRVFGAMADKGYIYHGAKPVYWSWSSESALAEAEIEYHDIDSTSLYYANRVKDGKDILDTDTYIVVWTTTPFTITASRGLTVGPDIDYVVVKPANDERKFLVAQALLSELAERFAWDNPQVLATHKGIELDRIVTIHPWDDNVEELVMNGDHVTLDSGTGIVHTAPGFGEDDYNVGVKYGLDVVVTVNERGIMMENAGPDFEGQFYDKVLPTVKEKLGDLLLASEVITHSYPFDWRTKKPIIWRAVPQWFASVSKFRQDILDEIDKVHFYPAWGKTRLYNMIRDRGDWVISRQRAWGVPLPIFYAEDGTAIMTKEVTDHIANLFEEHGSVIWWQREAKDLLPEGFTHPGSPNGEFTKENDIMDVWFDSGSSWNGVLNTREDLGYPADLYLEGSDQYRGWFNSSLITSVAVNGHAPYKSVLSQGFVLDGKGEKMSKSKGNIISPNDVAKQYGAEILRLWVASVDTDSDVRVSMEILGQVSETYRKIRNTLRFLIANTTDFNPYINKIAFEDLRSVDKYMLIKFNQLVSVINRAYSHYDFMTIYKAVVNFVTVDLSAFYLDFAKDVVYIEAADDLARRQMQTVFYEILVNITKLLTPILPHTSEEIWSYLEHEEEAFVQLAEMPEAQEFANQDEILDTWSAFMSLRDQAQKALEEARNAKIIGKSLEAHLTVYASEEVKTLLTALDSNIAQLLIVSQLTVTQEQAPKNALVFEDVAFSVEHARGHVCDRCRRIDETVKERPYHVTICNHCAAIVENHFPEAVRQGFESK","523423","","isoleucine-tRNA synthetase","Cytoplasm","Several matches in gapped BLAST to isoleucine-tRNA synthetase: residues 1-928 are 81% similar to the enzyme in S.pyogenes (gi15675414).Residues 1-930 are 77% similar to isoleucine-tRNA synthetase in S.pneumoniae (gi8928385).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0485 (0.0).","

InterPro
IPR001412
Family

Aminoacyl-tRNA synthetase, class I
PS00178	$\"[57-68]T$	AA_TRNA_LIGASE_I

InterPro
IPR002300
Domain

Aminoacyl-tRNA synthetase, class Ia
PF00133	$\"[26-634]T$	tRNA-synt_1

InterPro
IPR002301
Domain

Isoleucyl-tRNA synthetase, class Ia
PR00984	$\"[50-61]T$ $\"[228-251]T$ $\"[392-407]T$ $\"[520-533]T$ $\"[554-563]T$	TRNASYNTHILE
TIGR00392	$\"[13-835]T$	ileS

InterPro
IPR009008
Domain

ValRS-IleRS-LeuRS editing
SSF50677	$\"[201-394]T$	ValRS_IleRS_edit

InterPro
IPR009080
Domain

Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
SSF47323	$\"[645-919]T$	tRNAsyn_1a_bind

InterPro
IPR010663
Domain

Zinc finger, Fpg-type
PF06827	$\"[885-914]T$	zf-FPG_IleRS

InterPro
IPR013155
Domain

tRNA synthetase, valyl/leucyl, anticodon-binding
PF08264	$\"[678-834]T$	Anticodon_1

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[15-624]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
G3DSA:1.10.730.10	$\"[641-771]T$	G3DSA:1.10.730.10
PTHR11946	$\"[7-819]T$	PTHR11946
PTHR11946:SF9	$\"[7-819]T$	PTHR11946:SF9
SSF52374	$\"[1-644]T$	SSF52374

","BeTs to 17 clades of COG0060COG name: Isoleucyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0060 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001412 (Aminoacyl-transfer RNA synthetases class-I) with a combined E-value of 3.5e-10. IPB001412A 57-67 IPB001412B 592-602","Residues 136-185 are 86% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD002670) which is seen in SYI_STRPN.Residues 699-776 are 80% similar to a (SYNTHETASE LIGASE ISOLEUCYL-TRNA) protein domain (PD023651) which is seen in SYI_STRPN.Residues 580-696 are 73% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000476) which is seen in SYI_STRPN.Residues 384-579 are 83% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000647) which is seen in SYI_STRPN.Residues 314-371 are 36% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD004139) which is seen in SYI_METJA.Residues 186-245 are 75% similar to a (SYNTHETASE LIGASE ISOLEUCYL-TRNA) protein domain (PD186111) which is seen in SYI_STRPN.Residues 24-113 are 65% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000389) which is seen in SYI_STRPN.Residues 310-369 are 80% similar to a (SYNTHETASE LIGASE ISOLEUCYL-TRNA) protein domain (PD000939) which is seen in SYI_STRPN.Residues 807-916 are 72% similar to a (SYNTHETASE LIGASE ISOLEUCYL-TRNA) protein domain (PD009823) which is seen in SYI_STRPN.Residues 626-688 are 42% similar to a (SYNTHETASE PROTEOME ISOLEUCYL-TRNA) protein domain (PD210966) which is seen in Q9JXY7_NEIMB.Residues 633-693 are 48% similar to a (SYNTHETASE ISOLEUCYL-TRNA LIGASE) protein domain (PD259544) which is seen in SYI_STAAU.Residues 246-309 are 57% similar to a (SYNTHETASE LIGASE ISOLEUCYL-TRNA) protein domain (PD386565) which is seen in SYI_STRPN.Residues 631-778 are 31% similar to a (CG5414) protein domain (PD276669) which is seen in Q9VUY4_DROME.Residues 248-302 are 47% similar to a (SYNTHETASE LIGASE ISOLEUCYL-TRNA) protein domain (PD131012) which is seen in Q9CEH8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 10:35:40 2002","Thu Dec 6 08:06:37 2001","Thu Jul 27 09:33:14 2006","Wed Dec 5 10:36:36 2001","Wed Dec 5 10:36:36 2001","Wed Dec 5 10:36:36 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0508 is paralogously related (blast p-value < 1e-3) to SMu1611, a predicted valyl-tRNA synthetase, SMu1766,a predicted leucyl-tRNA synthetase, and SMu1492,a predicted methionyl-tRNA synthetase.","Mon Jan 14 10:37:45 2002","Thu Jul 27 09:33:14 2006","pdb1FFYA Chain A, Insights Into Editing From An Ile-Trna Synt... 1004 0.0pdb1ILE Isoleucyl-Trna Synthetase 310 3e-085pdb1GAXA Chain A, Crystal Structure Of Thermus Thermophilus V... 212 2e-055","SMU.558","","Residues 26 to 634 (E-value = 2.1e-250) place SMu0508 in the tRNA-synt_1 family which is described as tRNA synthetases class I (I, L, M and V) (PF00133)Residues 885 to 914 (E-value = 1.8e-09) place SMu0508 in the zf-FPG_IleRS family which is described as Zinc finger found in FPG and IleRS (PF06827)","Thu Jul 27 09:33:14 2006","24379039","","","Massidda,O., Anderluzzi,D., Friedli,L. and Feger,G.Unconventional organization of the division and cell wall genecluster of Streptococcus pneumoniaeMicrobiology 144 (Pt 11), 3069-3078 (1998)PubMed: 9846742 Chalker,A.F., Ward,J.M., Fosberry,A.P. and Hodgson,J.E.Analysis and toxic overexpression in Escherichia coli of astaphylococcal gene encoding isoleucyl-tRNA synthetaseGene 141 (1), 103-108 (1994)PubMed: 8163160Silvian,L.F., Wang,J. and Steitz,T.A.Insights into editing from an ile-tRNA synthetase structure withtRNAile and mupirocinScience 285 (5430), 1074-1077 (1999)PubMed: 10446055","","Wed Dec 5 10:58:27 2001","1","","","SMU.558","61" "SMu0509","524525","524199","327","ATGAATGGATACAGGAGGAAAAACATGAGATTAATCAATACGACTAGCAGTCATCAACATTTAGTTAAAAATCAACTAAAACATACTGATGCTACACTCGTTGAAACTTATTCAGCTGGCAATACCGACGTTATTTTCACTCAAGCGCCTAAACATTATGAACTTTTAATTTCAAACAAACATCGTGCTATCAAAGATAATGAAATTGAAACCATTCGAGAATTTTTCCTCAAGCGTAAAATTAATAAAAATATTATTTTATTAGATCAATTAAAAACACTGCATACTGCAAACCTAATTGAGATCTCCATTCCAATAGCTGATTAG","10.50","6.43","12548","MNGYRRKNMRLINTTSSHQHLVKNQLKHTDATLVETYSAGNTDVIFTQAPKHYELLISNKHRAIKDNEIETIREFFLKRKINKNIILLDQLKTLHTANLIEISIPIAD","524202","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins:residues 9-103 are 77% similar to S.pyogenes (gi|15675413|) and residues 9-106 are 71% similar to S.pneumoniae (gi|15900705|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0486 (2e-39).","

InterPro
IPR014959
Family

Domain of unknown function DUF1827
PF08860	$\"[9-106]T$	DUF1827

InterPro
IPR000086
Domain

NUDIX hydrolase
PR00502	$\"[64-78]T$ $\"[78-93]T$	NUDIXFAMILY
G3DSA:3.90.79.10	$\"[35-171]T$	NUDIX_hydrolase
PF00293	$\"[38-167]T$	NUDIX
PS00893	$\"[69-90]T$	NUDIX

InterPro
IPR015797
Domain

NUDIX
SSF55811	$\"[12-168]T$	NUDIX_hydrolase

noIPR
unintegrated

unintegrated
PTHR22769	$\"[42-148]T$	PTHR22769

","BeTs to 10 clades of COG0494COG name: NTP pyrophosphohydrolases (MutT family) including oxidative damage repair enzymesFunctional Class: L,RThe phylogenetic pattern of COG0494 is a-T-YqvCEBRHuj---linxNumber of proteins in this genome belonging to this COG is 6","***** IPB000086 (NUDIX hydrolase) with a combined E-value of 1.5e-10. IPB000086 64-90","Residues 21-166 are 60% similar to a (PROTEOME COMPLETE YXBC) protein domain (PD398025) which is seen in Q9CDI8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 26 15:23:42 2006","Thu Apr 25 16:23:10 2002","Tue May 3 11:49:19 2005","Wed Dec 5 11:09:12 2001","Wed Dec 5 11:09:12 2001","Wed Dec 5 11:09:12 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0510 is paralogously related (blast p-value < 1e-3) to SMu1470, a predicted conserved hypothetical.","Thu Mar 14 17:10:53 2002","","No significant hits to the NCBI PDB database.","SMU.561c","","Residues 38 to 167 (E-value = 2.1e-18) place SMu0510 in the NUDIX family which is described as NUDIX domain (PF00293)","Wed Dec 5 11:09:12 2001","24379041","","","","","","1","","","SMU.561c","651" "SMu0511","527395","525134","2262","ATGCTCTGTCAAAATTGTAAATTAAATGAAGCGACTATTCATCTATATGCTAATGTTAATGGTCAGCAAAAGCAGATTGACCTTTGTCAAAATTGTTATCAAATTATGAAAACAGATCCTGAAAATGGACCTTTAAATCATCTTTCGCAACAAAATTCATCATCCATCAATCCTTTCTTTGATGATTTCTTTGGCGATTTGAATAATTTTCGTGCCTTTAATAATCAAGATCTGCCAAACACACCGCCAACACAAGCTGGCGGCGGCAATGGCAACGGAGGCAATAATCGCCGTCCCGGCGGACCTCAGCAACAGGCCTCCCAAAAGCCAAATGGGTTGCTTGAAGAGTTTGGTATTAATTTAACAGATATTGCGCGCAAGGGTGAAATTGATCCTGTTATTGGCCGTGATGAAGAAATCACAAGGGTTATCGAAATTCTCAACCGTCGCACAAAGAATAATCCTGTTCTTATTGGAGAACCGGGTGTCGGTAAAACTGCTGTTGTCGAAGGACTGGCGCAAAAAATTGTTGATGGTGATGTTCCACAAAAATTACATGGAAAAAATGTCATTCGTCTGGACGTCGTCAGCCTTGTTCAAGGTACTGGTATTCGAGGCCAATTTGAAGAACGGATGCAAAAGCTAATGGAAGAAATCCGTCAACGTCAAGATGTTATTCTTTTCATTGATGAAATTCATGAAATTGTTGGTGCTGGTTCTGCTGGCGATGGCAATATGGATGCCGGAAATATTTTAAAACCCGCTTTGGCACGCGGTGAGCTTCAACTTGTTGGTGCTACAACACTCAATGAATATCGGATTATTGAAAAAGATGCCGCTTTGGAACGTCGAATGCAACCCGTAAAAGTTGATGAACCTAGTGTTGCAGAAACCATAACGATTCTTAAAGGTATTCAGCCCAAATATGAAGATTACCATCATGTAAAGTATACAGATGAAGCGATTGAAGCTGCTGCAAATCTTTCAAATCGTTACATTCAGGATCGTTTCTTACCTGATAAGGCTATTGATCTTCTAGATGAAGCTGGCTCTAAAATGAATTTAACACTTAACTTTGTAGATCCTAAAGAAATTGATCACCGCTTGATTGAAGCCGAAAATCTAAAAGCTCAAGCAACCCGTGATGAGGATTATGAAAAAGCAGCTTACTTCCGTGATCAAATTGCCAAATACAAGGAAATGCAATCCGCTAAACTTGATAAGGAGAATACTCCTGTTATTACAGAAAAAAATATTGAAGTAATTGTCGAGCAAAAGACCAATATTCCTGTTGGTGAATTAAAAGAAAAGGAACAATCACAATTAATTCATCTCGCTGACGATCTTAAAACGCGTGTTATTGGACAGGATGCTGCTGTTGATAAAATTGCTAAAGCTATTCGCCGCAATCGTGTTGGACTAGGCACTCCAAATCGGCCAATTGGTTCTTTCCTTTTTGTCGGCCCTACTGGTGTTGGTAAAACGGAACTCTCTAAACAATTAGCCATTGAGCTTTTTGGTTCTGAAGATAGTATGATTCGTTTCGATATGAGTGAATACATGGAAAAACATGCTGTGGCTAAACTTGTTGGTGCACCTCCGGGATATGTCGGTTATGAAGAAGCTGGTCAGTTAACCGAAAAAGTTCGTCGCAACCCTTATTCATTGATCTTACTCGATGAAGTTGAAAAAGCTCACCCAGATGTCATGCATATGTTCTTACAAGTGCTTGATGATGGTCGTCTAACGGATGGGCAAGGACGCACTGTCAGCTTTAAGGATACTATTATTATCATGACCTCAAATGCTGGTACAGGGAAATCTGAAGCTAATGTTGGTTTTGGTGCCAGTCGAGAAGGCCGTACTAATTCTGTTCTAGGCGAATTGGGTAACTTCTTTAGCCCTGAATTTATGAACCGTTTTGATGGTATCATCGAATTTCAGGCTTTAAGCAAGGATAATCTTCTTCAAATTGTTTCTCTCATGCTGGATGACGTTAATCAACGTTTAGCTGTTAATGCTATTCACCTTGATGTAACTGATAAAGTTAAAGAAAAATTGGTTGATCTCGGTTATGATCCTAAAATGGGAGCAAGACCGCTGCGTCGTACTATCCAAGAACATATTGAAGATGCTATTACGGATTTCTACTTAGAGCATCCTGAACAAAAAGAACTAAAAGCTATTATGACAAGCAATGGCAAAATTGTTATCAAGGCTTCTAACAAAGTCGAGACGGTTACCAAAGCAACTTCAGATTAA","5.20","-19.71","83728","MLCQNCKLNEATIHLYANVNGQQKQIDLCQNCYQIMKTDPENGPLNHLSQQNSSSINPFFDDFFGDLNNFRAFNNQDLPNTPPTQAGGGNGNGGNNRRPGGPQQQASQKPNGLLEEFGINLTDIARKGEIDPVIGRDEEITRVIEILNRRTKNNPVLIGEPGVGKTAVVEGLAQKIVDGDVPQKLHGKNVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVAETITILKGIQPKYEDYHHVKYTDEAIEAAANLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDHRLIEAENLKAQATRDEDYEKAAYFRDQIAKYKEMQSAKLDKENTPVITEKNIEVIVEQKTNIPVGELKEKEQSQLIHLADDLKTRVIGQDAAVDKIAKAIRRNRVGLGTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSEDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEANVGFGASREGRTNSVLGELGNFFSPEFMNRFDGIIEFQALSKDNLLQIVSLMLDDVNQRLAVNAIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYLEHPEQKELKAIMTSNGKIVIKASNKVETVTKATSD","525137","For other 'clp' genes see SMu0861 (clpX); SMu0868 (clpL), (clpE); SMu1844 (clpC); SMu1524 (clpP) and SMu1300 (clpB).For ATP-dependent Clp protease subunit X see SMu0861.For ATP-dependent Clp protease, ATP-binding subunit see SMu0868.For ATP-dependent Clp protease,ATP-binding subunit ClpB see SMu1300.For ATP-dependent Clp protease, proteolytic subunit see SMu1524. For ATP-dependent Clp protease, ATP-binding subunit see SMu1844. ","ATP-dependent protease ClpE","Cytoplasm","Residues 484-604 are 68% similar to a previously published hypothetical protein 1 (Sm1) sequence in Genbank gi97993 as seen in S.mutansNumerous matches in gapped BLAST to ATP-dependent Clp protease: residues 1-745 are 82% similar to the enzyme in S.pneumoniae (gi15900708).Residues 1-740 are 84% similar to the protein from S.pyogenes (gi15675411).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0488 (0.0).","

InterPro
IPR001270
Family

Chaperonin clpA/B
PR00300	$\"[484-502]T$ $\"[529-547]T$ $\"[558-576]T$ $\"[591-605]T$	CLPPROTEASEA
PS00870	$\"[247-259]T$	CLPAB_1
PS00871	$\"[514-532]T$	CLPAB_2

InterPro
IPR001943
Domain

UvrB/UvrC protein
PF02151	$\"[366-401]T$	UVR
PS50151	$\"[366-401]T$	UVR

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[151-291]T$ $\"[480-651]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[154-248]T$	AAA

InterPro
IPR013093
Domain

ATPase AAA-2
PF07724	$\"[479-644]T$	AAA_2

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.60	$\"[650-735]T$	G3DSA:1.10.8.60
G3DSA:3.40.50.300	$\"[110-303]T$ $\"[432-649]T$	G3DSA:3.40.50.300
PTHR11638	$\"[103-581]T$	PTHR11638
PTHR11638:SF19	$\"[103-581]T$	PTHR11638:SF19

","BeTs to 14 clades of COG0542COG name: ATPases with chaperone activity, ATP-binding domainFunctional Class: OThe phylogenetic pattern of COG0542 is --t-YQVCEBRhUJgpOLINxNumber of proteins in this genome belonging to this COG is 4","***** IPB001270 (Chaperonins clpA/B) with a combined E-value of 1.4e-219. IPB001270A 133-175 IPB001270B 176-224 IPB001270C 225-239 IPB001270D 265-319 IPB001270E 460-514 IPB001270F 541-595 IPB001270G 633-647 IPB001270H 691-705 IPB001270A 132-174***** IPB001943 (UvrB/uvrC motif) with a combined E-value of 2.4e-10. IPB001943B 146-155 IPB001943C 372-399","Residues 264-340 are 93% similar to a (PROTEASE ATP-BINDING PROTEOME COMPLETE ATP-DEPENDENT) protein domain (PD001382) which is seen in Q9CI09_LACLA.Residues 479-582 are 72% similar to a (COMPLETE PROTEOME SECRETION TYPE PLASMID ATP-BINDING) protein domain (PD000739) which is seen in CLPB_HELPJ.Residues 181-233 are 86% similar to a (PROTEASE ATP-BINDING SHOCK HEAT COMPLETE PROTEOME) protein domain (PD187342) which is seen in Q9CI09_LACLA.Residues 181-233 are 50% similar to a (PROTEASE ATP-DEPENDENT CLPE) protein domain (PD383562) which is seen in Q9Z6E5_LISMO.Residues 1-55 are 61% similar to a (PROTEASE ATP-BINDING PROTEOME COMPLETE) protein domain (PD414777) which is seen in Q9CI09_LACLA.Residues 320-474 are 29% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in CLPB_HELPJ.Residues 114-180 are 92% similar to a (PROTEASE ATP-BINDING COMPLETE SHOCK HEAT PROTEOME) protein domain (PD002024) which is seen in Q9CI09_LACLA.Residues 341-400 are 65% similar to a (PROTEASE ATP-BINDING ATP-DEPENDENT SHOCK) protein domain (PD005402) which is seen in Q9S5Z2_BBBBB.Residues 413-713 are 58% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9PQ99_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jul 27 09:38:19 2006","Wed Dec 5 12:41:47 2001","Thu Jul 27 09:38:19 2006","Wed Dec 5 12:41:47 2001","Wed Dec 5 12:41:47 2001","Wed Dec 5 12:41:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0511 is paralogously related (blast p-value < 1e-3) to SMu0868,a predicted ATP-dependent Clp protease, ATP-binding subunit, SMu1844,a predicted ATP-dependent Clp protease, ATP-binding subunit (Class III stressresponse-related ATPase), SMu1300,a predicted ATP-dependent Clp protease,ATP-binding chain B (ClpB), SMu1866,a predicted chromosome segregation helicase and SMu0861,a predicted ATP-dependent Clp protease subunit X.","Mon Jan 14 11:15:12 2002","","No significant hits to the NCBI PDB database.","SMU.562c","","Residues 154 to 347 (E-value = 5.7e-10) place SMu0511 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)Residues 483 to 714 (E-value = 5.7e-05) place SMu0511 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)","Thu Jul 27 09:38:19 2006","","","Gottesman,S., Squires,C., Pichersky,E., Carrington,M., Hobbs,M.,Mattick,J.S., Dalrymple,B., Kuramitsu,H., Shiroza,T., Foster,T.,Clark,W.P., Ross,B., Squires,C.L. and Maurizi,M.R.Conservation of the regulatory subunit for the Clp ATP-dependentprotease in prokaryotes and eukaryotesProc. Natl. Acad. Sci. U.S.A. 87 (9), 3513-3517 (1990)PubMed: 2185473","Steiner K, Malke H.relA-Independent amino acid starvation response network of Streptococcus pyogenes.J Bacteriol. 2001 Dec;183(24):7354-64.PMID: 11717294Chastanet A, Prudhomme M, Claverys JP, Msadek T.Regulation of Streptococcus pneumoniae clp genes and their role in competence development and stress survival.J Bacteriol. 2001 Dec;183(24):7295-307.PMID: 11717289 Skinner MM, Trempy JE.Expression of clpX, an ATPase subunit of the Clp protease, is heat and cold shock inducible in Lactococcus lactis.J Dairy Sci. 2001 Aug;84(8):1783-5.PMID: 11518300 Frees D, Varmanen P, Ingmer H.Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation of non-native proteins and concomitantly increases stress tolerance in Lactococcus lactis.Mol Microbiol. 2001 Jul;41(1):93-103.PMID: 11454203 ","Tue Mar 26 08:16:12 2002","Mon Jan 14 10:59:26 2002","1","","","SMU.562c","62" "SMu0512","527652","528632","981","ATGACAAAAGCAAAATCATTTTTAAAGGAAATAGATTACAGTAAGAAAGAGATAGAAGACTTCATTGATCTTGCTATGCAATTTAAAAAATTAAAAAAAGAACGCATTCCACACCGATATTTTGATGGACTCAATATTGCTTTAATTTTTGAAAAAACCTCTACAAGAACAAGGAGTGCTTTTACTGTTGCTGGGCAAGATCTGGGAATGAATGTGTCTTATTTAGGAAAAGATGACATTCAATTAGGGAAAAAAGAATCTCTTGTTGATACGGCTAAAGTTTTAGGAACCATGTTTGATGGTATCGAGTACCGTGGGTTTAAACAAGAGAGTGTTGAGCTCTTAGCGGAATTTTCTGGTGTGCCTGTTTGGAATGGACTAACAGATACTTGGCATCCCACACAGATGATTGCTGATTTTATGACTGTAAAAGAACATTTTGGGAAATTTGAAGATCTGACCTTAGCTTATCTAGGAGATGGCCGCAATAATGTTGCCAATTCTTTACTTGTGACGTCGGCTATTTTGGGGATTAATGTTAAAATCATAGCGCCTAAAGAGCTGCAGCCTGAGTCAGAAATTGTAGCTTTGGCTAAAAAGCATCAGACAAAAGGGCTAATTACAATTACTGATGACACTGCAGCTGTTGCCGATACTGATATTCTCTACACAGATATCTGGGTATCCATGGGAGAAAAGGTTGATTTTAAGGAAAGGATCGATTTATTACTGCCTTATCAGATCAATCAAGCTCTGCTTAATAGGGTTAGAAAGCCCAATGCTCTTGTTTTGCATTGCTTACCGGCCTTTCACGATCTCAATACTGAAATTGGCCGAGAAATTTACGAGCGGTACGGTTATAAAGAACTTGAAATGACAGATGCTGTATTTCAAAAGCATAGCCAGACTATTTTTCAAGAGGCAGAAAATCGTTTACATTCAATTAAAGCAATTATGTATCACTCCTTAAAAAATATCTAA","6.40","-2.86","37131","MTKAKSFLKEIDYSKKEIEDFIDLAMQFKKLKKERIPHRYFDGLNIALIFEKTSTRTRSAFTVAGQDLGMNVSYLGKDDIQLGKKESLVDTAKVLGTMFDGIEYRGFKQESVELLAEFSGVPVWNGLTDTWHPTQMIADFMTVKEHFGKFEDLTLAYLGDGRNNVANSLLVTSAILGINVKIIAPKELQPESEIVALAKKHQTKGLITITDDTAAVADTDILYTDIWVSMGEKVDFKERIDLLLPYQINQALLNRVRKPNALVLHCLPAFHDLNTEIGREIYERYGYKELEMTDAVFQKHSQTIFQEAENRLHSIKAIMYHSLKNI","528629","For other 'arg' genes see SMu0531 (argR); SMu0605 (argC); SMu0606 (argJ);SMu0607 (argB); SMu0608 (argD);SMu1904 (argS); SMu1903 (argR);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH).For other 'arc' genes see SMu0740 (arcT); SMu1901 (arcE) and SMu0241 (arcC). ","ornithine carbamoyltransferase","Cytoplasm","Numerous matches in gapped BLAST to ornithine carbamoyltransferase: residues 1-326 are 59% similar to the enzyme in Lactococcus lactis subsp. lactis (gi|15672783|).Residues 3-326 are 59% similar to the protein from S.pyogenes (gi|15675442|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2165 (1e-106).","

InterPro
IPR002292
Family

Ornithine carbamoyltransferase
PR00102	$\"[48-62]T$ $\"[81-94]T$ $\"[121-135]T$ $\"[222-232]T$ $\"[302-313]T$	OTCASE
TIGR00658	$\"[5-324]T$	orni_carb_tr

InterPro
IPR006130
Family

Aspartate/ornithine carbamoyltransferase
PR00100	$\"[50-69]T$ $\"[132-143]T$ $\"[259-268]T$ $\"[288-311]T$	AOTCASE
PIRSF000416	$\"[5-324]T$	OCT_ATCase
PS00097	$\"[50-57]T$	CARBAMOYLTRANSFERASE

InterPro
IPR006131
Domain

Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region
PF00185	$\"[150-322]T$	OTCace

InterPro
IPR006132
Domain

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
PF02729	$\"[5-146]T$	OTCace_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1370	$\"[4-132]T$ $\"[135-325]T$	G3DSA:3.40.50.1370
PIRSF500170	$\"[5-325]T$	OCTase
PTHR11405	$\"[133-272]T$ $\"[290-325]T$	PTHR11405
PTHR11405:SF1	$\"[133-272]T$ $\"[290-325]T$	PTHR11405:SF1
SSF53671	$\"[1-148]T$ $\"[148-326]T$	SSF53671

","BeTs to 13 clades of COG0078COG name: Ornithine carbamoyltransferaseFunctional Class: EThe phylogenetic pattern of COG0078 is amtkyqvcEbrh---po----Number of proteins in this genome belonging to this COG is 2","***** IPB002029 (Aspartate and ornithine carbamoyltransferase family) with a combined E-value of 1.3e-59. IPB002029A 43-70 IPB002029B 80-105 IPB002029C 122-160 IPB002029D 257-278","Residues 12-145 are 68% similar to a (CARBAMOYLTRANSFERASE ASPARTATE ORNITHINE BIOSYNTHESIS) protein domain (PD000708) which is seen in OTCA_LACPL.Residues 151-197 are 76% similar to a (ORNITHINE CARBAMOYLTRANSFERASE ARGININE) protein domain (PD407303) which is seen in OTCC_STRPY.Residues 246-319 are 48% similar to a (ORNITHINE CARBAMOYLTRANSFERASE ARGININE OTCASE CATABOLIC) protein domain (PD244504) which is seen in Q9K3A1_STAAU.Residues 246-323 are 48% similar to a (ORNITHINE TRANSFERASE) protein domain (PD414068) which is seen in O53089_LACSK.Residues 153-319 are 37% similar to a (ASPARTATE CARBAMOYLTRANSFERASE BIOSYNTHESIS ORNITHINE) protein domain (PD124925) which is seen in OTCA_SYNY3.Residues 153-198 are 52% similar to a (ORNITHINE TRANSFERASE) protein domain (PD409592) which is seen in O87319_NOSPU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 15:45:04 2002","Mon Jan 14 13:21:26 2002","Wed Apr 3 09:22:56 2002","Wed Dec 5 12:48:26 2001","Wed Dec 5 12:48:26 2001","Wed Dec 5 12:48:26 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0512 is paralogously related (blast p-value < 1e-3) to SMu0238,a predicted ornithine carbamoyltransferase (OTCase) and SMu0782, a predicted aspartate transcarbamoylase.","Mon Jan 14 13:24:04 2002","Wed Dec 5 12:48:26 2001","pdb|1DXH|A Chain A, Catabolic Ornithine Carbamoyltransferase Fr... 291 6e-080pdb|1ORT|A Chain A, Ornithine Transcarbamoylase From Pseudomona... 289 4e-079pdb|1DUV|G Chain G, Crystal Structure Of E. Coli Ornithine Tran... 284 1e-077","SMU.563","","Residues 5 to 147 (E-value = 1.1e-67) place SMu0512 in the OTCace_N family which is described as Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain (PF02729)Residues 150 to 323 (E-value = 3.1e-55) place SMu0512 in the OTCace family which is described as Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain (PF00185)","Wed Dec 5 12:48:26 2001","24379043","","","Bringel,F., Frey,L., Boivin,S. and Hubert,J.C.Arginine biosynthesis and regulation in Lactobacillus plantarum:the carA gene and the argCJBDF cluster are divergently transcribedJ. Bacteriol. 179 (8), 2697-2706 (1997)PubMed: 9098069Nicoloff,H., Hubert,J.C. and Bringel,F.In Lactobacillus plantarum, carbamoyl phosphate is synthesized bytwo carbamoyl-phosphate synthetases (CPS): carbon dioxidedifferentiates the arginine-repressed from the pyrimidine-regulated CPSJ. Bacteriol. 182 (12), 3416-3422 (2000)PubMed: 10852872Zuniga,M., Champomier-Verges,M., Zagorec,M. and Perez-Martinez,G.Structural and functional analysis of the gene cluster encoding the enzymes of the arginine deiminase pathway of Lactobacillus sakeJ. Bacteriol. 180 (16), 4154-4159 (1998)PubMed: 9696763","","Wed Dec 5 12:57:43 2001","1","","","SMU.563","503" "SMu0513","528709","528939","231","ATGGAATCACACTTGGTGAGAATTATTAATCGTTTGGAATTAATGACGACTGACAGCAATAATTTGAAACGTCATTTTGAACGTGATGGTGCTGTTGTTGCAGAGGTTTCCTTTAATAATGATCCAGAAAACGGTCCTGTCTTTACTTTGCGGGATGTTGCTGCGCATGAGACTTATACTTTTGATAGTATTGACCTTATTGCAATGGAAATCTACGATTTACTTTATTAA","4.40","-7.29","8771","MESHLVRIINRLELMTTDSNNLKRHFERDGAVVAEVSFNNDPENGPVFTLRDVAAHETYTFDSIDLIAMEIYDLLY","528936","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins:residues 1-76 are 85% similar to S.pyogenes (gi|15675410|) and 76% similar to S.pneumoniae (gi|15900710|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0490 (9e-34).","

InterPro
IPR014904
Family

Protein of unknown function DUF1797
PF08796	$\"[8-75]T$	DUF1797

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-76 are 38% similar to a (PROTEOME COMPLETE) protein domain (PD389478) which is seen in Q9CDS4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 13:29:23 2002","Wed Dec 5 13:03:39 2001","Mon Jan 14 13:29:23 2002","Wed Dec 5 13:03:39 2001","","Wed Dec 5 13:03:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0513 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 13:29:23 2002","","No significant hits to the NCBI PDB database.","SMU.564","","No significant hits to the Pfam 11.0 database","Wed Dec 5 13:03:39 2001","24379044","","","","","","1","","","SMU.564","902" "SMu0514","529843","529007","837","TTGGTAACGGAGTTTTCTTTAGACATTCTTCTAAAGATTATTAAGCTCGCTCGTTCAACCTATTATTACCACTTAAAGCAGCTAGATAAAAGCAATAAAGATCATGCTATTAAAGCTGAAATTCAAGCTATTTTTACTGAGCACAAAGGAAATTATGGTTATCGTCGAATGACTCTTGAATTGAGAAATCGTGGCTTCTTGGTAAATCATAAAAAGGTTCAACGTCTAATGAAAGTTCTTGGTTTGGAGGCTCGTATTCGTCGCAAACGGAAGTATTCTTCCTACCAAGGAGAGGTGGGCAAGAAAGCAGACAACCTTATTCAACGCCAATTTGAAGCATCAAAACCAATGGAAAAGTGCTACACAGATGTGACAGAATTTGCCATTCCAGCAAGCGGTCAAAAGCTCTATTTGTCACCAGTTTTAGATGGTTTCAACAGTGAAATTATTGCTTATAACCTTTCTACGTCACCGAACTTGATACAAGTGAAAGCTATGCTAGAACAGGCTTTCACAGAGAAACATTACACAAATACTATTCTTCATAGTGACCAAAGCTGGCAATACCAGCATGATTTTTATCATCAATTTTTAGAGAACAAGGGGATTCAGCCGTCCATGTCACGTAAAGGAAACAGCCCAGATAATGGCATGATGGAATCTTTCTTTGGCATTTTGAAATCCGAAATGTTTTACGGTTATGAGAAGACATTTAAGTCACTTAAGCAATTGGAACAAGCTATTGTAGACTATATTGATTATTACAACAACAAACGTATTAAGGTAAAACTAAAAGGACTTAGTCCTGTACAGTACAGAACGAAATCCTTTACTTAA","10.40","17.88","32485","MVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGNYGYRRMTLELRNRGFLVNHKKVQRLMKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQFEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIAYNLSTSPNLIQVKAMLEQAFTEKHYTNTILHSDQSWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT","529010","","transposase (ISIS861)","Cytoplasm","Several matches in gapped BLAST to putative transposase:residues 203-277 are 97% similar to previously published transposase from S.mutans (gi|3873218|). Residues 1-276 are 83% similar to the enzyme in S.pneumoniae (gi|8163693|). Residues 8-276 are 72% similar to the protein from S.pyogenes (gi|15675275|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (1e-121).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[111-273]T$	rve
PS50994	$\"[111-276]T$	INTEGRASE

noIPR
unintegrated

unintegrated
PD688335	$\"[34-75]T$	Q8DVC7_STRMU_Q8DVC7;
signalp	$\"[1-18]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 230-272 are 51% similar to a (ELEMENT ORFB B. CRYIIB) protein domain (PD410106) which is seen in Q57057_BACAN.Residues 162-202 are 80% similar to a (TRANSPOSASE ELEMENT COMPLETE) protein domain (PD335900) which is seen in Q9KK23_STRPN.Residues 121-161 are 95% similar to a (TRANSPOSASE ELEMENT INSERTION COMPLETE) protein domain (PD006527) which is seen in Q9KK23_STRPN.Residues 11-149 are 27% similar to a (TRANSPOSASE) protein domain (PD102854) which is seen in Q48525_LACCA.Residues 58-118 are 73% similar to a (TRANSPOSASE COMPLETE ELEMENT OF) protein domain (PD245714) which is seen in Q9KK23_STRPN.Residues 205-272 are 95% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in Q9KK23_STRPN.Residues 4-55 are 76% similar to a (TNIA ISTB TNIBDELTA1 COMPLETE) protein domain (PD402756) which is seen in Q9KK23_STRPN.Residues 124-197 are 39% similar to a (TRANSPOSASE OF PROTEOME COMPLETE) protein domain (PD395630) which is seen in O50351_LACHE.Residues 9-55 are 48% similar to a (TRANSPOSASE ELEMENT PROTEOME FOR) protein domain (PD195495) which is seen in INSK_ECOLI.Residues 205-255 are 86% similar to a (TRANSPOSASE PLASMID COMPLETE OF) protein domain (PD000334) which is seen in Q53640_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 13:33:27 2002","Mon Jan 14 13:29:48 2002","Tue Mar 19 08:15:41 2002","Wed Dec 5 13:12:08 2001","","Wed Dec 5 13:12:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0514 is paralogously related (blast p-value < 1e-3) to SMu1719, SMu1283, SMu1258, SMu0695, SMu0395, SMu0798, SMu1250, SMu0934, SMu0537, SMu1237, SMu1236, and SMu1235 all predicted transposases.","Wed Jan 16 08:31:45 2002","","No significant hits to the NCBI PDB database.","SMU.565c","","Residues 111 to 273 (E-value = 1.2e-38) place SMu0514 in the rve family which is described as Integrase core domain (PF00665)","Wed Dec 5 13:12:08 2001","24379045","","","Rubens,C.E., Heggen,L.M. and Kuypers,J.M. IS861, a group B streptococcal insertion sequence related to IS150 and IS3 of Escherichia coli J. Bacteriol. 171 (10), 5531-5535 (1989) PubMed: 2477359 ","Mon Jan 14 13:33:27 2002","Tue Mar 19 08:15:41 2002","1","","","SMU.565c","" "SMu0515","530355","529837","519","ATGAAATTGACTTATGAAGATAAAGTTCTCATCTATGAACTGAAAAACCAAGGGTATAGCTTAGAGCAGCTTTCAAATAAATTTGGGATAAAAATTTCTAATCTTAGCTACATGATTAAATTGATTGATCATTACGGAATAGAGATCGTCAAAAAAGGAAAGAATCGTTACTATTCTCCTGAACTAAAACAAGAAATCATTGATAAAGTTCTTCTTGAAGGTCGTTCACAAATAAGGGTGTCTCTAGATTATGCTCTTCCAAGTCATGGAATGTTGCCTAATTGGATAGCACAATACAAGAAAAATAGGTATACTATTGTTGAGAAAACAAGAGGGAGACCACCTAAAATGGGACGTAAGCCAAAGAAGAAATCGGAAGAAATGACAGAGCTAGAGCAACTTCAGAAAGAATTAGAATATCTGAGAGCGGAGAATGCTGTTCTAAAAAAGTTGAGAGAACTCCGATTGAGGGAAGAAAAAGAGCAAGAAGAAAAACGGAAATTGTCCGAGGATTGGTAA","10.40","10.49","20606","MKLTYEDKVLIYELKNQGYSLEQLSNKFGIKISNLSYMIKLIDHYGIEIVKKGKNRYYSPELKQEIIDKVLLEGRSQIRVSLDYALPSHGMLPNWIAQYKKNRYTIVEKTRGRPPKMGRKPKKKSEEMTELEQLQKELEYLRAENAVLKKLRELRLREEKEQEEKRKLSEDW","529840","","transposase, IS861-associated","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins and to degenerate transposase (orf1):residues 1-147 are 73% similar to S.pneumoniae (gi8163692).Residues 1-167 are 65% similar to S.pyogenes (gi15674401).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1526 (9e-37).","

InterPro
IPR002514
Family

Transposase IS3/IS911
PF01527	$\"[55-148]T$	Transposase_8

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[3-96]T$	Homeodomain_like

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 38-108 are 67% similar to a (DOMAIN OF UNKNO N) protein domain (PD354820) which is seen in Q53639_STRAG.Residues 1-37 are 78% similar to a (DOMAIN OF UNKNO N) protein domain (PD230559) which is seen in Q9KK22_STRPN.","","Thu Nov 29 18:31:56 2001","Thu Nov 29 18:31:56 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 13:35:50 2002","Tue Sep 26 13:05:05 2006","Tue Sep 26 13:05:05 2006","Wed Dec 5 13:30:57 2001","","Wed Dec 5 13:30:57 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0515 is paralogously related (blast p-value < 1e-3) to SMu1720, SMu1284, SMu1257, SMu0694, and SMu0396, all predicted conservedhypotheticals,possibly transposon IS861 associated.","Tue Jan 22 12:41:13 2002","","No significant hits to the NCBI PDB database.","SMU.566c","Thu Nov 29 18:31:56 2001","Residues 55 to 148 (E-value = 5.3e-06) place SMu0515 in the Transposase_8 family which is described as Transposase (PF01527)","Wed Dec 5 13:30:57 2001","24379046","","","","","","1","","","SMU.566c","" "SMu0516","530592","531278","687","ATGGATTTTTCATTTTTATCTAAATATTGGGCTTATTTTAATTATGGTGTTCTTGTAACCATCATGATTTCAGCCTGTGTTGTCTTTTTTGGGACGATTATTGGTGTTCTTGTGGCTTTGATTAAACGCAGTCGTATCAAGGTTTTAGATTGGCTGGTTTCCTTTTACGTGTGGATTTTTCGTGGTACTCCTATGGTTGTGCAAATTATGATTTCTTTTGTCCTTTTACATTTTACCAATATGCCAATTGTTAAATTTGGTGTTTTAGATTTGGATTTTTCCCGTCTTTTGCCAGGGATTATTGTCCTGTCACTTAATAGTGGGGCCTATATTTCAGAAGTTGTTCGTGCAGGAATTGAAGCAGTGCCTAAAGGACAATTAGAAGCCGCTTATTCTTTAGGAATTAAGCCGGTAAATGCCATGCGCTATGTCATCTTGCCGCAAGCTTTCAAAAATATTTTGCCTGCTTTGGGGAATGAATTTATCACAATTATCAAAGACAGCTCTCTTTTACAAACGATTGGGGTTATGGAACTATGGAATGGCGCTCAATCAGTCGTAACGGCAACCTATCTGCCTTTGACCCCACTTTTATTTGGTGCCTTTTATTATTTGATGGTGACAACCTTGATGTCAGCACTTGTTAAATTACTTGAAAATCGTTTTGGTAAAGGAGATGCCAGCTAA","10.10","5.18","25342","MDFSFLSKYWAYFNYGVLVTIMISACVVFFGTIIGVLVALIKRSRIKVLDWLVSFYVWIFRGTPMVVQIMISFVLLHFTNMPIVKFGVLDLDFSRLLPGIIVLSLNSGAYISEVVRAGIEAVPKGQLEAAYSLGIKPVNAMRYVILPQAFKNILPALGNEFITIIKDSSLLQTIGVMELWNGAQSVVTATYLPLTPLLFGAFYYLMVTTLMSALVKLLENRFGKGDAS","531275","For other components see SMu0517 (NBD1).For other 'gln' genes see SMu0517 (glnQ);SMu0732 (glnP); SMu0328 (glnR);SMu0329 (glnA); SMu0741 (glnH);SMu1080 (glnP);SMu1509 (glnB);SMu1380 (glnQ);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP).","amino acid (glutamine) ABC transporter permease","Membrane, Cytoplasm","Several matches in gapped BLAST to ABC transporter (permease protein): residues 1-225 are 80% similar to the protein in S.pyogenes (gi15675409).Residues 1-226 are 69% similar to the protein from S.pneumoniae (gi15902771). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0491 (1e-102).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[13-224]T$	BPD_transp_1
PS50928	$\"[17-215]T$	ABC_TM1

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[9-117]T$	HEQRo_perm_3TM

","BeTs to 7 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 153-208 are 67% similar to a (TRANSPORT PERMEASE ABC TRANSPORTER) protein domain (PD006016) which is seen in Q9CEN9_LACLA.Residues 16-76 are 55% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC COMPLETE) protein domain (PD001196) which is seen in Q9CEN9_LACLA.Residues 153-219 are 34% similar to a (AMINO-ACID MEMBRANE ABC TRANSPORT) protein domain (PD413409) which is seen in Y4TG_RHISN.Residues 99-149 are 78% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in Q9CEN9_LACLA.Residues 151-222 are 33% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE SYSTEM INNER PROTEOME) protein domain (PD415578) which is seen in Q9KLI6_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 13:55:13 2006","Tue Aug 29 13:55:13 2006","Tue Aug 29 13:55:13 2006","Wed Dec 5 13:37:30 2001","","Wed Dec 5 13:37:30 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0516 is paralogously related (blast p-value < 1e-3) to SMu0219, SMu1080, SMu0732, SMu1382, SMu1111, SMu1383, SMu0417, SMu0848, SMu0847, and SMu0595, all predicted amino acid ABC transporters, permease components.","Wed Apr 3 11:04:20 2002","","No significant hits to the NCBI PDB database.","SMU.567","","Residues 13 to 224 (E-value = 4.6e-32) place SMu0516 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Dec 5 13:37:30 2001","24379047","","","","","","1","","","SMU.567","535" "SMu0517","531278","532012","735","ATGTCAGAAACACTTATCAGTATTAAAAATTTACATAAACATTTTGGTAAAAATGAGGTACTCAAGGGAATTGACCTTGATATCAAACAAGGAGAAGTTCTTGTTATTATTGGACCATCAGGATCAGGAAAGTCAACTTTTTTACGGACAATGAATCTTTTGGAAGTACCAACCAAAGGGAGCATTACGTTTGAAGGTGTTGATATTACCGATAAATCCAATGATATTTTCAAAATGCGTGAAAAGATGGGAATGGTTTTCCAACAATTTAATCTTTTCCCTAATATGACTGTTTTGGAAAATATTACGCTTTCTCCTATTAAAACCAAAGGGCTTAGTAAGGCAGAAGCAGAAGAAAAGGCTTATCAGCTTTTGGATAAGGTAGGTTTGCGTGATAAGGCAGCAGCCTATCCGCAAAGTCTATCAGGTGGACAGCAACAGCGGATCGCTATTGCGCGTGGCTTAGCTATGGATCCAGACGTACTTCTTTTTGATGAGCCAACATCAGCTCTTGATCCAGAAATGGTCGGCGAAGTGTTAAGTGTTATGCAAGACCTTGCTAAATCAGGGATGACCATGGCTATTGTCACCCATGAAATGGGCTTTGCACATGAAGTGGCTGATCGTGTGATTTTCATGGATGATGGTATTATTGTTGAAGAGGGAGCTCCTGAAGAAGTTTTTAAAAATGCCAAAGAAGAAAGGACCAGGGATTTCCTTGGAAAAGTGTTATAA","4.90","-8.02","26892","MSETLISIKNLHKHFGKNEVLKGIDLDIKQGEVLVIIGPSGSGKSTFLRTMNLLEVPTKGSITFEGVDITDKSNDIFKMREKMGMVFQQFNLFPNMTVLENITLSPIKTKGLSKAEAEEKAYQLLDKVGLRDKAAAYPQSLSGGQQQRIAIARGLAMDPDVLLFDEPTSALDPEMVGEVLSVMQDLAKSGMTMAIVTHEMGFAHEVADRVIFMDDGIIVEEGAPEEVFKNAKEERTRDFLGKVL","532009","For other components see SMu0516 (MSD1) and (SBP1).For other 'gln' genes see SMu0516 (glnP);SMu0732 (glnP); SMu0328 (glnR);SMu0329 (glnA); SMu0741 (glnH);SMu1080 (glnP);SMu1509 (glnB);SMu1380 (glnQ);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP).","glutamine ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several matches in gapped BLAST to amino acid ABC transporter (ATP-binding protein): residues 1-244 are 81% similar to the protein in S.pyogenes (gi15675408).Residues 1-244 are 80% similar to the protein from S.pneumoniae (gi15900712).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0492 (1e-116).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[141-183]T$	ABC_transporter
PF00005	$\"[31-216]T$	ABC_tran
PS00211	$\"[141-155]T$	ABC_TRANSPORTER_1
PS50893	$\"[6-240]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-217]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-242]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-243]T$	PTHR19222
PTHR19222:SF33	$\"[6-243]T$	PTHR19222:SF33
SSF52540	$\"[5-243]T$	SSF52540

InterPro
IPR007167
Family

FeoA
PF04023	$\"[1-71]T$ $\"[79-151]T$	FeoA

","BeTs to 4 clades of COG1918COG name: FeoA protein, probably involved in Fe2+ transportFunctional Class: PThe phylogenetic pattern of COG1918 is amT---vce------------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 81-149 are 53% similar to a (COMPLETE PROTEOME IRON FERROUS) protein domain (PD057225) which is seen in Q9CJ18_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 12:57:46 2006","Mon Jan 14 14:29:34 2002","Wed Sep 27 12:57:46 2006","Wed Dec 5 14:23:11 2001","","Wed Dec 5 14:23:11 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0518 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 19 08:22:16 2002","","No significant hits to the NCBI PDB database.","SMU.569","","Residues 1 to 71 (E-value = 2e-12) place SMu0518 in the FeoA family which is described as FeoA domain (PF04023)Residues 79 to 151 (E-value = 3.7e-24) place SMu0518 in the FeoA family which is described as FeoA domain (PF04023)","Wed Sep 27 12:57:46 2006","24379049","","","Kammler,M., Schon,C. and Hantke,K.Characterization of the ferrous iron uptake system of EscherichiacoliJ. Bacteriol. 175 (19), 6212-6219 (1993)PubMed: 8407793","","Tue Mar 19 08:22:16 2002","1","","","SMU.569","" "SMu0519","532678","534828","2151","ATGACAGAAATTGCTTTGATTGGGAATCCCAATAGCGGAAAGACAAGTTTATTTAACCTTTTAACAGGGACAAGTCAGCGTGTTGGGAATTGGCCTGGTGTAACCGTTGAGCGTAAGAGCGGTAATGTCAAAAAGCTCAAAGAGATTAGTGTTCAGGACTTACCAGGTATTTATTCCATGTCTCCGTACAGTCCTGAAGAAAAAGTAGCACGTGATTATCTGCTGAGTAATCATGCAGACAGCATTTTAAACGTGGTTGATGCCACGAATCTGGAACGCAACCTTTACCTAACGACGCAGTTAATTGAGACAGGAATTCCTGTAACGATTGCGCTTAATATGAGCGATGTGTTAAAAAATCAAGGAAAATCTATTAATAGTGATAAATTGGCTTATCAGATGGGAGTGCCAGTTGTTGCGACCAGTGCTTTGAAAAATACAGGCGTTGACAAGGCTGTTAAAAAAGCCAGTCAAACAACTAAGGGCAGTGTTGATAGTGTTCAATACCCAACTTACGATGCCAAATTTGAAGCAGCGATTGCCCAAATTATTGAGGTTCTCGGTCAGACAGTACCAGAACGTTCTAGCCGTTTTTATGCCATCAAATTATTTGAGCGCGACCGTTTGGTTGAAGAGGAATTAGATTTATCTCCCTTTCAAAAGAAGGAAATTAAAGACATCATTCAAATCACCGAGGAAGTCTTCACAGAAGATTCAGAGTCCATCGTGATTAATCAGCGTTATGCTTTCATTGAACGTGTGAGCCAAATGGCACAAAGTCAAGATAATGATTTTAAGATGTCTGCTTCTGATAAAATTGATAAAATTGTGACTAATCGCGTTTTGGCTCTGCCCATTTTTGCGGTCGTTATGTTCTTAGTTTATTACTTGTCCATTCAAACGGTGGGAACAATGGGGACGGATTGGGTTAATGATATTCTTTTTGGTAAATACGTACCTGAATTTGTCACAGGTGTTTTAGAGGCATTGAAAGTGCAGGCTTGGCTACAATCGTTGATTATTGATGGGGTTGTTGCTGGTGTTGGGACAGTTCTTGGCTTTTTACCGCAAATTTTTGTCCTCTTTATCTGTCTGGGAATTCTAGAAGATATTGGTTATATGAGTCGAATTGCTTTTGTTATGGATCGGATTTTCAGACGTTTCGGACTTTCAGGAAAATCCTTTATTCCTATGCTTATTTCAACGGGGTGTGGTGTTCCGGGAATTATGGCCAGTCGAACCATTGAGAATGAACGTGATCGTCGTATTACCATTATGACAACGACTTTTATGCCTTGTTCAGCTAAGCTGTCCGTCATTGCCTTAATTGCGGGAGCCTTTTTCCCTCATAATCCTTGGATAGCTCCAAGTGCTTATTTCATGGGAATGATTGCTATTATTTTATCAGGTATTGCCCTTAAGAAAACTAGTTTTTTAGGCGGTTATACGAGTCCTTTTATCATGGAATTACCAAGTTATCATCTACCAAAGGTTGATGCTGTTTTGCGCTATGCTTTTGGTAAGGCTATGAGTTTTGTTAAGCGTGCTGGAACGATTATCTTTAGTTTAACCGTTTTAATCTGGTTTATGAGTTCCTATAATTTTACTTTGCATTCAGTTGATACGGAAAACAGTATTCTGGCTAGTCTTGGTCGTCTCTTGGCTTGGATCTTTACACCGCTTGGTTTTGGAAATTGGAAGGCGACTGTAGCTGCTCTGACTGGTCTTGCAGCTAAGGAAACAGTAGTTGCAACTTTTGGAATTCTCTACAATAATCCCGATGCAACAGAAACAACGCATTCACTATGGGTTAGCCTTCAGGGGGATTATACAGCTTTGGCAGCCTATTCATTTTTGACCTTCAATTTGCTTTGTGCGCCTTGTTTTGCCTCAATCGGAGCTATCAAGCGCGAAATGGGAAATCTGAAGTGGACTTTAGTGGCTATTGCTTATCAAACGGGTCTGGCTTATCTTGTTAGCTTAATTATTTACCAGCTTGGTTTAGTTGCTTTTTATGGTAAGCCAGTGACGCTTTGGACAGGTTTAGCTCTTGTTTTATTGCTTGTGATGCTTTACTTTATTATTAGAAAACCACGTCAGGTCAAAGAAAAAGTGATTACCTTAGATAATTTAAGTTTAAGTCATAACTAA","8.80","6.24","79091","MTEIALIGNPNSGKTSLFNLLTGTSQRVGNWPGVTVERKSGNVKKLKEISVQDLPGIYSMSPYSPEEKVARDYLLSNHADSILNVVDATNLERNLYLTTQLIETGIPVTIALNMSDVLKNQGKSINSDKLAYQMGVPVVATSALKNTGVDKAVKKASQTTKGSVDSVQYPTYDAKFEAAIAQIIEVLGQTVPERSSRFYAIKLFERDRLVEEELDLSPFQKKEIKDIIQITEEVFTEDSESIVINQRYAFIERVSQMAQSQDNDFKMSASDKIDKIVTNRVLALPIFAVVMFLVYYLSIQTVGTMGTDWVNDILFGKYVPEFVTGVLEALKVQAWLQSLIIDGVVAGVGTVLGFLPQIFVLFICLGILEDIGYMSRIAFVMDRIFRRFGLSGKSFIPMLISTGCGVPGIMASRTIENERDRRITIMTTTFMPCSAKLSVIALIAGAFFPHNPWIAPSAYFMGMIAIILSGIALKKTSFLGGYTSPFIMELPSYHLPKVDAVLRYAFGKAMSFVKRAGTIIFSLTVLIWFMSSYNFTLHSVDTENSILASLGRLLAWIFTPLGFGNWKATVAALTGLAAKETVVATFGILYNNPDATETTHSLWVSLQGDYTALAAYSFLTFNLLCAPCFASIGAIKREMGNLKWTLVAIAYQTGLAYLVSLIIYQLGLVAFYGKPVTLWTGLALVLLLVMLYFIIRKPRQVKEKVITLDNLSLSHN","534825","For other 'feo' genes see SMu0518 (feoA).","ferrous ion transport protein B","Membrane, Cytoplasm","Several matches in gapped BLAST to ferrous ion transport protein B: residues 1-697 are 56% similar to the protein from Lactococcus lactis subsp. lactis (gi15672169).Residues 4-672 are 37% similar to the protein from Clostridium acetobutylicum (gi15894318).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1013 (2e-04).","

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[2-116]T$	MMR_HSR1

InterPro
IPR003373
Family

Ferrous iron transport protein B
TIGR00437	$\"[8-638]T$	feoB

InterPro
IPR006073
Domain

GTP1/OBG
PR00326	$\"[4-24]T$ $\"[25-43]T$	GTP1OBG

InterPro
IPR011619
Domain

Ferrous iron transport protein B, N-terminal
PF02421	$\"[149-347]T$	FeoB_N

InterPro
IPR011640
Domain

Ferrous iron transport B, C-terminal
PF07664	$\"[454-508]T$	FeoB_C

InterPro
IPR011642
Domain

Nucleoside recognition
PF07670	$\"[351-447]T$ $\"[513-642]T$	Gate

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-168]T$	G3DSA:3.40.50.300
PTHR11649	$\"[4-150]T$	PTHR11649
PTHR11649:SF5	$\"[4-150]T$	PTHR11649:SF5
SSF52540	$\"[2-158]T$	SSF52540

","BeTs to 9 clades of COG0370COG name: Ferrous ion uptake system protein FeoB (predicted GTPase)Functional Class: PThe phylogenetic pattern of COG0370 is AmTk-qvce---uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB003373 (Ferrous iron transport protein B) with a combined E-value of 1.3e-54. IPB003373A 30-72 IPB003373B 80-112 IPB003373C 118-154 IPB003373D 270-297 IPB003373D 338-365***** IPB000765 (GTP1/OBG family) with a combined E-value of 1.5e-10. IPB000765 2-45","Residues 548-667 are 55% similar to a (TRANSPORT IRON FERROUS PROTEOME) protein domain (PD072412) which is seen in Q9CJ19_LACLA.Residues 460-532 are 65% similar to a (TRANSPORT IRON FERROUS PROTEOME) protein domain (PD006094) which is seen in Q9CJ19_LACLA.Residues 237-303 are 46% similar to a (TRANSPORT FERROUS IRON B) protein domain (PD009505) which is seen in Q9CJ19_LACLA.Residues 313-447 are 70% similar to a (TRANSPORT IRON FERROUS COMPLETE) protein domain (PD005672) which is seen in Q9CJ19_LACLA.Residues 107-151 are 57% similar to a (TRANSPORT IRON PROTEOME COMPLETE) protein domain (PD338381) which is seen in Q9CJ19_LACLA.Residues 398-448 are 49% similar to a (TRANSPORT IRON FERROUS PROTEOME) protein domain (PD302988) which is seen in Q9HW43_PSEAE.Residues 58-106 are 59% similar to a (TRANSPORT IRON FERROUS PROTEOME) protein domain (PD337288) which is seen in Q9CJ19_LACLA.Residues 1-57 are 70% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9CJ19_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 12:58:05 2006","Mon Jan 14 14:32:33 2002","Wed Sep 27 12:58:05 2006","Wed Dec 5 14:31:56 2001","Wed Dec 5 14:31:56 2001","Wed Dec 5 14:31:56 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0519 is paralogously related (blast p-value < 1e-3) to SMu1744,a predicted phosphoglycerate dehydrogenase and SMu0004,a predicted uncharacterized GTP-binding protein","Mon Jan 14 14:33:59 2002","","No significant hits to the NCBI PDB database.","SMU.570","","Residues 6 to 667 (E-value = 1.8e-230) place SMu0519 in the FeoB family which is described as Ferrous iron transport protein B (PF02421)","Wed Dec 5 14:31:56 2001","24379050","","","Kammler,M., Schon,C. and Hantke,K.Characterization of the ferrous iron uptake system of EscherichiacoliJ. Bacteriol. 175 (19), 6212-6219 (1993)PubMed: 8407793Velayudhan J, Hughes NJ, McColm AA, Bagshaw J, Clayton CL, Andrews SC, Kelly DJ.Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high-affinity ferrous iron transporter.Mol Microbiol. 2000 Jul;37(2):274-86.PMID: 10931324Hantke K.Ferrous iron uptake by a magnesium transport system is toxic for Escherichia coli and Salmonella typhimurium.J Bacteriol. 1997 Oct;179(19):6201-4.PMID: 9324273 ","","Mon Jan 14 14:35:04 2002","1","","","SMU.570","" "SMu0520","534841","534993","153","ATGACTATGTCAACCTTTATTATTGCTATCTTAATTGCAGTTGGAGCTTTCTTAGGAATCCGTCATTATATTAAGCAGAAAGGTTCTTGTGGCGATTGTGACTGTGCCTGCCCTGTTAAAGATGAGATGAAAAAATCAAGCAAGACACATTAA","8.50","3.27","5431","MTMSTFIIAILIAVGAFLGIRHYIKQKGSCGDCDCACPVKDEMKKSSKTH","534990","","hypothetical protein","Periplasm, Membrane","No significant hits in gapped BLAST.SMu0520 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-16]?$	signal-peptide
tmhmm	$\"[4-24]?$	transmembrane_regions

InterPro
IPR000672
Domain

Tetrahydrofolate dehydrogenase/cyclohydrolase
PD002300	$\"[21-132]T$	THFDhg/Cyc_hydro
PR00085	$\"[33-55]T$ $\"[74-101]T$ $\"[109-130]T$ $\"[154-174]T$ $\"[203-232]T$ $\"[238-254]T$ $\"[255-273]T$	THFDHDRGNASE
PF00763	$\"[3-120]T$	THF_DHG_CYH
PF02882	$\"[123-282]T$	THF_DHG_CYH_C
PS00766	$\"[75-100]T$	THF_DHG_CYH_1
PS00767	$\"[259-267]T$	THF_DHG_CYH_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.192.10	$\"[28-114]T$	G3DSA:3.40.192.10
G3DSA:3.40.50.720	$\"[132-263]T$	G3DSA:3.40.50.720
PTHR10025	$\"[12-280]T$	PTHR10025
SSF51735	$\"[122-283]T$	SSF51735
SSF53223	$\"[1-121]T$	SSF53223

","BeTs to 13 clades of COG0190COG name: 5,10-methylene-tetrahydrofolate dehydrogenaseFunctional Class: HThe phylogenetic pattern of COG0190 is ----YqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000672 (Tetrahydrofolate dehydrogenase/cyclohydrolase) with a combined E-value of 4.1e-120. IPB000672A 33-62 IPB000672B 69-120 IPB000672C 148-195 IPB000672D 202-232 IPB000672E 238-274","Residues 94-270 are 24% similar to a (PROTEOME COMPLETE DEHYDROGENASE) protein domain (PD316754) which is seen in Q9PQF4_UREPA.Residues 21-278 are 70% similar to a (METHYLENETETRAHYDROFOLATE DEHYDROGENASE CYCLOHYDROLASE) protein domain (PD002300) which is seen in FOLD_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:41:02 2007","Thu Sep 7 11:14:37 2006","Thu Sep 7 11:14:37 2006","Wed Dec 5 14:51:00 2001","Wed Dec 5 14:51:00 2001","Wed Dec 5 14:51:00 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0521 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 19 08:24:33 2002","Thu Sep 7 11:14:37 2006","pdb1B0AA Chain A, 5,10, Methylene-Tetrahydropholate Dehydroge... 229 4e-061pdb1DIAA Chain A, Human Methylenetetrahydrofolate Dehydrogena... 202 4e-053pdb1A4IB Chain B, Human Tetrahydrofolate Dehydrogenase CYCLO... 202 4e-053","SMU.572","","Residues 3 to 120 (E-value = 4.2e-64) place SMu0521 in the THF_DHG_CYH family which is described as Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain (PF00763)Residues 122 to 282 (E-value = 6.8e-100) place SMu0521 in the THF_DHG_CYH_C family which is described as Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain (PF02882)","Thu Sep 7 11:14:37 2006","24379052","","","Maskell JP, Sefton AM, Hall LM.Multiple mutations modulate the function of dihydrofolate reductase in trimethoprim-resistant Streptococcus pneumoniae.Antimicrob Agents Chemother. 2001 Apr;45(4):1104-8.PMID: 11257022Pikis A, Donkersloot JA, Rodriguez WJ, Keith JM.A conservative amino acid mutation in the chromosome-encoded dihydrofolate reductase confers trimethoprim resistance in Streptococcus pneumoniae.J Infect Dis. 1998 Sep;178(3):700-6.PMID: 9728538 ","","Mon Jan 14 14:40:44 2002","1","","","SMU.572","282" "SMu0522","535964","536797","834","ATGATTATTGATGATCTTTTAACGAAAAAAATAATTAAACCACGTCCTCTTAACAGTCACAAGGGGACTTTTGGCCGTGTCCTTTTGATTGGCGGCAACTACCCTTACGGTGGTGCTATCATCATGGCTGCCCTTGCTTGTGTCAATAGCGGAGCTGGTTTGGTGACGGTTGCGACCCATAAGGACAATATCACAGCTCTGCACAGCCATTTACCCGAAGCTATGGCTTTTGATATGGTTGAAAAAGATCGTTTGTCAGAGCAAATAACAGCAGCAGATGTGGTTCTTATGGGACCGGGCTTGGCAGAAGATGACTTGGCTCAAACAACCTTTGATGTGGTTTGGCAGGCTATCGAACCAAAACAGACTTTGATTATTGATGGCTCTGCTATAAATCTATTAGCCAAAAGAAAACCAGCTATTTGGCCAACCAAGCAAATAATCCTAACACCCCATCAAAAAGAATGGGAAAGATTGTCTGGACTGACTATTCCAGAACAGATAGAAGCAGCAACACAAACAGCACTAGCTCATTTTCCAAAAGAAACCATCCTAGTCGCAAAATCCCATCAGACCAAGATTTATCAAGGACAAAAAATCGGACATATCCAAGTTGGCGGTCCCTATCAAGCGACTGGCGGTATGGGAGATACCTTGGCTGGAATGATTGCAGGCTTTGTTGCTCAATTTCACACAGACCGCTTTGAGGTTGCCGCAGCCGCTGTCTTCCTCCACTCCTACATAGCAGACCAATTGAGCAAGGAGGCCTATGTCGTCCTACCAACCAGAATCAGTGCGGAGATAACAAGAGTGATGAAGGAGATGAGTGAGTGA","6.90","-0.64","30072","MIIDDLLTKKIIKPRPLNSHKGTFGRVLLIGGNYPYGGAIIMAALACVNSGAGLVTVATHKDNITALHSHLPEAMAFDMVEKDRLSEQITAADVVLMGPGLAEDDLAQTTFDVVWQAIEPKQTLIIDGSAINLLAKRKPAIWPTKQIILTPHQKEWERLSGLTIPEQIEAATQTALAHFPKETILVAKSHQTKIYQGQKIGHIQVGGPYQATGGMGDTLAGMIAGFVAQFHTDRFEVAAAAVFLHSYIADQLSKEAYVVLPTRISAEITRVMKEMSE","536794","","conserved hypothetical protein","Cytoplasm, Membrane","Several matches in gapped BLAST to conserved hypothetical proteins:residues 1-276 are 59% similar to S.thermophilus (gi2829822).Residues 2-273 are 55% similar to S.pneumoniae (gi15902774).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0495 (2e-76).","

InterPro
IPR000631
Domain

Carbohydrate kinase
PF01256	$\"[27-270]T$	Carb_kinase
TIGR00196	$\"[1-274]T$	yjeF_cterm
PS01050	$\"[213-223]T$	UPF0031_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.20	$\"[2-276]T$	G3DSA:3.40.1190.20
PTHR12592	$\"[1-228]T$	PTHR12592
SSF53613	$\"[7-276]T$	SSF53613

","BeTs to 12 clades of COG0063COG name: Predicted sugar kinaseFunctional Class: GThe phylogenetic pattern of COG0063 is amtkyqvcebr-uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000631 (Uncharacterized protein family UPF0031) with a combined E-value of 1.2e-22. IPB000631A 20-32 IPB000631B 90-102 IPB000631C 148-159 IPB000631E 213-223","Residues 175-275 are 60% similar to a (COMPLETE PROTEOME 0710008K08RIK FIS) protein domain (PD118745) which is seen in YFOL_STRTR.Residues 29-173 are 60% similar to a (COMPLETE PROTEOME 0710008K08RIK III) protein domain (PD005102) which is seen in YFOL_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jun 4 20:16:01 2008","Thu Dec 6 08:37:03 2001","Wed Jun 4 20:16:01 2008","Thu Dec 6 08:37:03 2001","Thu Dec 6 08:37:03 2001","Thu Dec 6 08:37:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0522 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jun 4 20:16:01 2008","","No significant hits to the NCBI PDB database.","SMU.573","","Residues 27 to 270 (E-value = 1.8e-79) place SMu0522 in the Carb_kinase family which is described as Carbohydrate kinase (PF01256)","Thu Dec 6 08:37:03 2001","24379053","","","","Wed Jun 4 20:16:53 2008","","1","","","SMU.573","652" "SMu0523","537854","537123","732","ATGGCACTGTTAAAATCACCTATTTTTGGTATTTGTTTTTCATTAATCCTTTATACGATCGGGCAAGATTTATTCAAAAAGAGTAAAGGCTTCTTTCTCTTACAACCCCTTTTCTTTGCTATGGTTGCAGGCATTATCGTACTTGTTTTATTGGCAAAAGGATTGGGAACTGATGTTAAAACCTTATATACTCAAGCTTATAAACCCGGCGGAGATTTGATTTTCTGGTTCCTTAATCCCGCAACCATTGCCTTTGCCGTTCCACTTTATAAGAAAAATGACGCTGTCAAAAAATATTGGAAGGAAATCATCAGCAGTTTGATTATCGGTATGGTCGTTTCCTTAATCATCATTGTTGCTATTTCAAAAGCTATTGGTTTAAGCCAAGCTAGCACTGCTTCTATGCTGCCGCAGGCAGCAACAACAGCCATTGCTCTCCCTATTGCTCACGCTATCGGCGGCAATACTGCCATCACTGCCATGGCTTGTATCCTAAACGCCGTTATTATCTATGCTTTAGGCAAAAAATTAGTTGCTCTCTTCCACCTCAATAAGAGTGAAATCGGTGTTGGCTTAGGTTTAGGAACATCTGGTCATACAGTTGGTGCAGCCTTTGCTCTAGAATTAGGAGAACTACAAGGTGCCATGGCTGCCATCGCAGTTGTTGTCATCGGCCTCGTCGTTGACTTGGTTATTCCTATCTTTAGCTACATGATAGGATTAGTGCACTAA","10.20","7.85","25520","MALLKSPIFGICFSLILYTIGQDLFKKSKGFFLLQPLFFAMVAGIIVLVLLAKGLGTDVKTLYTQAYKPGGDLIFWFLNPATIAFAVPLYKKNDAVKKYWKEIISSLIIGMVVSLIIIVAISKAIGLSQASTASMLPQAATTAIALPIAHAIGGNTAITAMACILNAVIIYALGKKLVALFHLNKSEIGVGLGLGTSGHTVGAAFALELGELQGAMAAIAVVVIGLVVDLVIPIFSYMIGLVH","537126","","effector of murein hydrolase ","Membrane, Cytoplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins :residues 6-240 are 51% similar to this protein in B.subtilis (gi16079942).Residues 7-239 are 30% similar to this protein in Lactococcus lactis subsp.lactis (gi15672743).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0185 (1e-105).","

InterPro
IPR007300
Family

LrgB-like protein
PF04172	$\"[14-239]T$	LrgB

noIPR
unintegrated

unintegrated
SSF103481	$\"[76-176]T$	SSF103481

","BeTs to 3 clades of COG1346COG name: Predicted membrane protein, YohK familyFunctional Class: SThe phylogenetic pattern of COG1346 is ---k----eB-h---------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 14-213 are 50% similar to a (PROTEOME COMPLETE TRANSMEMBRANE BH3268) protein domain (PD009617) which is seen in P94516_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 14 14:45:28 2002","Tue Mar 6 14:19:06 2007","Tue Mar 6 14:19:06 2007","Thu Dec 6 08:42:37 2001","","Thu Dec 6 08:42:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0523 is paralogously related (blast p-value < 1e-3) to SMu1548, a predicted conserved hypothetical protein; possible membrane protein.","Mon Jan 14 14:45:28 2002","","No significant hits to the NCBI PDB database.","SMU.574c","","Residues 14 to 239 (E-value = 1.6e-90) place SMu0523 in the LrgB family which is described as LrgB-like family (PF04172)","Thu Dec 6 08:42:37 2001","24379054","","","","","","1","","","SMU.574c","" "SMu0524","538323","537856","468","ATGAAACACACTAGTAAAGTAACACAATCAAAATCAGCACCTATGTTTATTCAAATGTCTATCTATGCTGCTATTCTGCTCGTTTCTCAGCTTATTTCAGAATTATTGCCTAAAGCCTTACCGATTCCAACCACCGTTATTGGTTTAGTTCTCATGTATGTCCTTTTGTGCAGCCATATTATCAAAATTGAATGGGTTGATTCCTTGGGTTCCTTATTAATTAGTATGATTGGCTTTATGTTTGTCCCATCAGGCATTTCCCTAGCAGCCAATTTAAATATTCTCAAAGCTGAAGGATTGCAGTTGGTCGCTGTTATTAGCCTATCGACCATTCTCATGCTAGTCATTGTCACCTATATCACTTCTATTATTCTGTCTATCAAAAAGGTGAATGTGGCAAGTCTGTGGGAAAAATGGACTGCTCATAGCTTTGAAAAGAAATTTAGTAAGAAAGTAGAGGGAAAATAA","10.40","7.66","17014","MKHTSKVTQSKSAPMFIQMSIYAAILLVSQLISELLPKALPIPTTVIGLVLMYVLLCSHIIKIEWVDSLGSLLISMIGFMFVPSGISLAANLNILKAEGLQLVAVISLSTILMLVIVTYITSIILSIKKVNVASLWEKWTAHSFEKKFSKKVEGK","537859","","murein hydrolase regulator ","Membrane, Cytoplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins :residues 18-127 are 47% similar to this protein in B.subtilis (gi16079943).Residues 15-117 are 24% similar to this protein in Lactococcus lactis subsp. lactis (gi15672744).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0184 (2e-56).","

InterPro
IPR005538
Family

LrgA
PD009239	$\"[49-125]T$	LrgA
PF03788	$\"[15-126]T$	LrgA

","BeTs to 3 clades of COG1380COG name: Predicted membrane protein, YohJ familyFunctional Class: SThe phylogenetic pattern of COG1380 is ---k----eB-h---------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 16-125 are 39% similar to a (PROTEOME COMPLETE TRANSMEMBRANE BH3269) protein domain (PD009239) which is seen in P72358_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 08:28:51 2002","Tue Mar 6 14:24:29 2007","Thu Sep 28 09:41:31 2006","Thu Dec 6 10:23:56 2001","","Thu Dec 6 10:23:56 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0524 is paralogously related (blast p-value < 1e-3) to SMu1549, a predicted conserved hypothetical protein.","Tue Mar 19 08:28:51 2002","","No significant hits to the NCBI PDB database.","SMU.575c","","Residues 15 to 126 (E-value = 9.4e-20) place SMu0524 in the LrgA family which is described as LrgA family (PF03788)","Thu Dec 6 10:23:56 2001","24379055","","","","","","1","","","SMU.575c","" "SMu0525","539233","538499","735","ATGAACATTTTAATTCTTGATGATGAAATGTTGGCAAGACAAGAGTTAACTTTTTTAATTCAGCAGAGTAAGGAACTTGATCATCCTGATATTTTTGAAGCTGAAGATATTAGCAGTGCTGAAAAAATTCTCTTTCGCCAGCAGATTGATTTAATTTTTCTTGATATTTCACTCAGCGAGGAAAATGGTTTTACCTTGGCCAACCAATTAGAGCAATTGGCACATCCTCCACTTGTCGTCTTTGCGACAGCCTATGATCATTATGCCGTTAAAGCTTTTGAAAGCAATGCTGCTGACTATATTTTGAAGCCTTTTGAGCAGGGGCGTGTGGATAAAGCTTTGGCTAAAGTTAAGAAAATACAACACTTATCTACAATAGATGAAACAGCTACGACAGAAAAGAAAGGTATGGAACTGTTAACACTGACTTTAGCAGATAGAAGCATTGTCCTTAAGATGCCAGACATTGTGGCCGCTAGCATTGAAGATGGAGAACTGACCGTCAGTACCAAAAACACGAGCTACACCATCAAGAAAACATTGAATTGGTTTAAAACTCGCGCCAAGACCAATTATTTCCTGCAGATTCATCGCAATACAGTTGTTAATCTGGAAATGATTCAGGAAATTCAGCCTTGGTTTAACCATACGCTCTTACTGGTGATGGTCAATGGTGAAAAATTCCCAGTCGGGCGTTCCTATATGAAAGAATTGAATGCTCATTTGACCTTATAA","5.30","-7.30","27899","MNILILDDEMLARQELTFLIQQSKELDHPDIFEAEDISSAEKILFRQQIDLIFLDISLSEENGFTLANQLEQLAHPPLVVFATAYDHYAVKAFESNAADYILKPFEQGRVDKALAKVKKIQHLSTIDETATTEKKGMELLTLTLADRSIVLKMPDIVAASIEDGELTVSTKNTSYTIKKTLNWFKTRAKTNYFLQIHRNTVVNLEMIQEIQPWFNHTLLLVMVNGEKFPVGRSYMKELNAHLTL","538502","For other 'lyt' genes see SMu0526 (lytS). ","response regulator","Cytoplasm","Several matches in gapped BLAST to two-component response regulator proteins: residues 1-238 are 44% similar to the protein from Bacillus subtilis (gi|16079944|).Residues 1-244 are 38% similar to the protein from S.aureus (gi|15923251|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0183 (1e-107).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[1-117]T$	Response_reg
PF00072	$\"[1-115]T$	Response_reg
SM00448	$\"[1-114]T$	REC
PS50110	$\"[2-118]T$	RESPONSE_REGULATORY

InterPro
IPR007492
Domain

LytTr DNA-binding region
PF04397	$\"[146-243]T$	LytTR
PS50930	$\"[140-244]T$	HTH_LYTTR

InterPro
IPR008246
Family

Response regulator, LytTR DNA-binding AlgR/VirR/ComE type
PIRSF006198	$\"[1-244]T$	RR_LytTR_AlgR

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-125]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[1-129]T$	G3DSA:3.40.50.2300

","BeTs to 7 clades of COG0784COG name: CheY-like receiver domainsFunctional Class: TThe phylogenetic pattern of COG0784 is AMTkYqVCEBrhUJ--Ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB001789 (Response regulator receiver domain) with a combined E-value of 1.1e-07. IPB001789A 3-9 IPB001789B 50-63 IPB001789C 96-105***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 1.9e-07. IPB001867A 50-63 IPB001867B 76-120","Residues 3-116 are 51% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in P94514_BACSU.Residues 1-210 are 21% similar to a (COMPLETE CDS GENES ORF1) protein domain (PD315123) which is seen in Q9KWM3_BBBBB.Residues 193-238 are 58% similar to a (COMPLETE PHOSPHORYLATION PROTEOME) protein domain (PD020177) which is seen in P94514_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 16:06:22 2002","Tue Jan 8 12:11:23 2002","Thu Oct 24 10:50:49 2002","Thu Dec 6 09:22:36 2001","Thu Dec 6 09:22:36 2001","Thu Dec 6 09:22:36 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0525 is paralogously related (blast p-value < 1e-3) to SMu0392, SMu1379, SMu1653, SMu1048, SMu1782, SMu1748, SMu0601 and SMu0265, all predicted response regulators.","Mon Jan 14 09:04:16 2002","","No significant hits to the NCBI PDB database.","SMU.576c","","Residues 1 to 122 (E-value = 1.2e-18) place SMu0525 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 139 to 243 (E-value = 4.6e-19) place SMu0525 in the LytTR family which is described as LytTr DNA-binding domain (PF04397)","Thu Dec 6 09:22:36 2001","","","","","","Thu Oct 24 16:06:22 2002","1","","","SMU.576c","" "SMu0526","540956","539214","1743","ATGTTAATGATATTATTATTTCAGAGACTTGGTATTATCATGATTCTGGCATTTTTACTAGTCAATAACAGCTATTTTCGACAGTTGATTGAAGAACGTTCTAAGCGTGAAAAGCTGGTTCTTATTATCATTTTTGGTATTTTCGTCATCATTTCCAATATGACAGGAATTGAAATCACTAGCGATAAAAGTTTGGTGGAACGTCCTATTCTAACGACTATTTCTCATTCAGATTCTCTAGCTAATACGAGAACTTTGGTTATCACAACGGCTAGCTTAGTCGGCGGTCCTTTAGTTGGAACTGTTGTGGGTTTCATTGGTGGTGTCCATCGTTTCTTTCAAGGGAATTTTTCTGGTGCTTTTTACATTGTCAGTTCTGCTTTGGTAGGATATATTAGTGGTCGACTGGGTGATCAATTAAAAACTAATAACCTTTATCCATCTACTTCGCAGGTCATTGTTATCAGCATTATTGCTGAAAGTATTCAAATGCTCTTTGTCGGTTTCTTTACTGGCTGGGATTTGGTTAAACTGATTTTCATTCCTATGATGTTGCTTAACAGTCTAGGTTCGACCTTATTTCTAGCTATTCTCAAGACCTACTTATCCAATGAAAGACAGCTGAGAGCTGTTCAGACTCGGGATGTTTTAGATTTGACGCAGCAAACCCTTCCTTATTTAAGACAGGGACTGAGTCAGCAATCAGCTACTAAAGTGTGTAATATCATTAAGCAGCATACTAATTTTGATGCCGTTGGTCTGACTGATCGAACCAATGTCCTAGCTCATATCGGCGTTGGTCAAGATCATCATATTGCCGGACAAGCGGTCAAAACAGATCTCTCAAAAAGTGTTATTTTAAACGGTCAGCCACAAATTGCCTTAGATAAAACAGCCATTGCCTGTCCAGACCAAAGCTGTCTCCTCAATTCAGCCATCGTCGTTCCGCTCAAGATCAATAATGAGACAGTTGGGGCCTTAAAAATGTACTTTTCTGGTGATAAGAAGATGACCGAAGTCGAAGAAAATCTTGCCCTAGGTCTCGCACAAATTTTTTCTGGACAATTGGCCATCGGTATTGCCGAGGAACAAAATAAGTTGGCTAATATTGCAGAAATCAAGGCCTTGCAGTCCCAGATTAATCCCCATTTCTTCTTCAATGCTATAAACACCATCAGTGCTTTGATTCGTCTTGATGCCAACAAAGCTCGATATGCTCTCATGCAATTAAGTACTTTTTTCCGAACCAGTTTACAAGGCGGACAAGATAGAGAAATCTCTTTAGAACAGGAAAAAGCGCACGTTGATGCTTATATGAATCTTGAAAAGCTGCGCTTTCCTGATAAATATCAACTGGATTATCATATTACTGTTTCAACTAAAATGACCCTGCCTCCTTTTGGTTTGCAGGTTTTGGTTGAAAATGCAGTGCGTCATGCTTTTAAAGAACGCAAGAAAGACAATCATATTTGTATTTCCATAACAGATCAGGGAGAGTTTTACAAGGTGGCCGTTAGCGATAATGGTCAGGGTATTTCTCCTAATATGATTGACAAATTAGGACAGGAAACTGTATCTGAAAGCAAGGGAACAGGAACAGCCCTTGTTAATTTAAACAATCGCCTAAATTTACTTTATGGCAGTGCTAGTCAGTTACACTTTGACAGTACAGATCAAGGAACAACCGTCTGGTATGAGATTCCTTATCAAAAAGGAGATAAAGATGAACATTTTAATTCTTGA","7.70","2.96","64265","MLMILLFQRLGIIMILAFLLVNNSYFRQLIEERSKREKLVLIIIFGIFVIISNMTGIEITSDKSLVERPILTTISHSDSLANTRTLVITTASLVGGPLVGTVVGFIGGVHRFFQGNFSGAFYIVSSALVGYISGRLGDQLKTNNLYPSTSQVIVISIIAESIQMLFVGFFTGWDLVKLIFIPMMLLNSLGSTLFLAILKTYLSNERQLRAVQTRDVLDLTQQTLPYLRQGLSQQSATKVCNIIKQHTNFDAVGLTDRTNVLAHIGVGQDHHIAGQAVKTDLSKSVILNGQPQIALDKTAIACPDQSCLLNSAIVVPLKINNETVGALKMYFSGDKKMTEVEENLALGLAQIFSGQLAIGIAEEQNKLANIAEIKALQSQINPHFFFNAINTISALIRLDANKARYALMQLSTFFRTSLQGGQDREISLEQEKAHVDAYMNLEKLRFPDKYQLDYHITVSTKMTLPPFGLQVLVENAVRHAFKERKKDNHICISITDQGEFYKVAVSDNGQGISPNMIDKLGQETVSESKGTGTALVNLNNRLNLLYGSASQLHFDSTDQGTTVWYEIPYQKGDKDEHFNS","539217","For other 'lyt' genes see SMu0525 (lytT),(lytR). ","sensor histidine kinase","Membrane, Cytoplasm","Several matches in gapped BLAST to two-component sensor histidine kinase proteins: residues 2-576 are 43% similar to this protein in Bacillus subtilis (gi16079945).Residues 2-575 are 42% similar to this protein in S.aureus (gi15923250).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0182 (0.0).","

InterPro
IPR003018
Domain

GAF
PF01590	$\"[231-360]T$	GAF
SM00065	$\"[215-366]T$	GAF

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[421-577]T$	ATP_bd_ATPase
PF02518	$\"[464-570]T$	HATPase_c
SM00387	$\"[464-571]T$	HATPase_c
SSF55874	$\"[425-569]T$	ATP_bd_ATPase

InterPro
IPR010559
Domain

Histidine kinase internal region
PF06580	$\"[372-454]T$	His_kinase

InterPro
IPR011620
Domain

5TM Receptors of the LytS-YhcK type, transmembrane region
PF07694	$\"[34-137]T$	5TM-5TMR_LYT

noIPR
unintegrated

unintegrated
SSF55781	$\"[211-364]T$	SSF55781

","BeTs to 6 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 376-453 are 48% similar to a (KINASE COMPLETE PROTEOME HISTIDINE) protein domain (PD007406) which is seen in Q53705_STAAU.Residues 461-568 are 33% similar to a (KINASE COMPLETE PROTEOME HISTIDINE) protein domain (PD088883) which is seen in P94513_BACSU.Residues 2-362 are 38% similar to a (COMPLETE PROTEOME OF SECTION) protein domain (PD014600) which is seen in P94513_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 09:35:58 2006","Thu Sep 28 09:35:58 2006","Thu Sep 28 09:35:58 2006","Thu Dec 6 10:35:20 2001","","Thu Dec 6 10:35:20 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0526 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 14:52:25 2002","","No significant hits to the NCBI PDB database.","SMU.577c","","Residues 231 to 360 (E-value = 2.9e-05) place SMu0526 in the GAF family which is described as GAF domain (PF01590)Residues 372 to 455 (E-value = 9.3e-42) place SMu0526 in the His_kinase family which is described as Histidine kinase (PF06580)Residues 464 to 570 (E-value = 2.8e-14) place SMu0526 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Thu Sep 28 09:35:58 2006","","","","Brunskill,E.W. and Bayles,K.W.Identification and molecular characterization of a putativeregulatory locus that affects autolysis in Staphylococcus aureusJ. Bacteriol. 178 (3), 611-618 (1996)PubMed: 8550490","","Thu Dec 6 10:37:25 2001","1","","","SMU.577c","" "SMu0527","541399","542742","1344","ATGTCAGATTATTTATCAGTATCCTCTTTAACCAAATATTTAAAATTAAAATTTGATCGCGATCCTTATTTGGAACGAGTTTATCTGACAGGTCAGGTTTCTAATTTCAGAAGACGTCCCAATCATCAGTATTTCTCCCTTAAAGATGAGAAAGCTGTCATTCAGGCGACCATGTGGAGCGGTATTTATAGGAAATTGGGCTTTGAGCTCGAAGAAGGCATGAAAATCAATGTTATTGGTCGTGTGCAACTGTATGAACCTAGTGGTTCTTATTCCATCATCATTGAAAAGGCAGAGCCAGATGGTATTGGTGCACTGGCTGTTCAGTTTGAACAACTTAAGAAAAAACTGGCTGAGGCTGGTTATTTTGACGATAGGCATAAACAAAGACTGTCGCAGTTTGTTAAAAAGATTGGTGTTGTCACCAGTCCTAGTGGAGCGGTTATTAGAGATATTATCACAACAGTCTCGCGTCGTTTTCCCGGTGTAGATATTTTACTTTTTCCAACTAAAGTTCAAGGTGAAGGGGCAGCACAGGAAGTGGCTGACAACATTCGTTTGGCTAATGAACGTACTGATTTAGACCTGCTCATTGTTGGTCGTGGTGGGGGTTCTATTGAAGATCTCTGGGCTTTTAATGAGGAGATTGTAGTGCAGGCCATTTTTGAATCGCATCTGCCCATTATTTCCAGCGTTGGACATGAGACGGATACAACCTTGGCTGATTTTGCGGCAGATCGCAGAGCAGCAACGCCAACAGCAGCAGCTGAATTGGCAACACCTGTGACCAAGGCTGATTTATTAGCTTTTCTTAAAGAAAGACAGATGAGATCTTATCAGGCTGTTATGCGTCTGATTAGACAAAAGGATGAACAAGTTAAGAAACTGCAAAGATCAGTTATTTTCAGACAGCCTGAAAGACTCTATGATGCTTATGTTCAAAAATTGGATCATTTAAGAACACATTTGTTGACCAAGGTGCGGCAGGTTTATGATGTTTATGATAGCAAGGAACATTTGCTGAGACAAAGATTGTTGTCCTTTAATTTATCAGGGTGTATTCAGCGCTATCAAGCACAATTAAAACAAGATCAGCGTTTATTGTTAAGCCACATGAGCAGTCAATATGATAGTAAATTAGCCCGTTTTGAAAAAGCACAAGATGCGCTTTTGTCACTGGATACGACTCGGATTGTGGCGCGTGGCTATGCTATTGTTCAAAAAGATAATCACATTATTCAATCAACCCAACAGATCAAAAAAGGAGATCGCTTGCATCTTGAAATGAAAGATGGGCAGGTTCAAGTGGAGGTAGAAAATGTCAAACAAGAAGAAAACATTTGA","9.90","9.40","51135","MSDYLSVSSLTKYLKLKFDRDPYLERVYLTGQVSNFRRRPNHQYFSLKDEKAVIQATMWSGIYRKLGFELEEGMKINVIGRVQLYEPSGSYSIIIEKAEPDGIGALAVQFEQLKKKLAEAGYFDDRHKQRLSQFVKKIGVVTSPSGAVIRDIITTVSRRFPGVDILLFPTKVQGEGAAQEVADNIRLANERTDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESHLPIISSVGHETDTTLADFAADRRAATPTAAAELATPVTKADLLAFLKERQMRSYQAVMRLIRQKDEQVKKLQRSVIFRQPERLYDAYVQKLDHLRTHLLTKVRQVYDVYDSKEHLLRQRLLSFNLSGCIQRYQAQLKQDQRLLLSHMSSQYDSKLARFEKAQDALLSLDTTRIVARGYAIVQKDNHIIQSTQQIKKGDRLHLEMKDGQVQVEVENVKQEENI","542739","For other 'xse' genes see SMu0528 (xseB) For exodeoxyribonuclease VII, small subunit see SMu0528.From Genbank [gi:14194717] This protein bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides which are then degraded further into small acid-soluble oligonucleotides.","exodeoxyribonuclease VII, large subunit","Cytoplasm","Several matches in gapped BLAST to exodeoxyribonuclease VII (large subunit) proteins: residues 1-444 are 72% similar to the enzyme in S.pyogenes (gi|15675404|).Residues 1-445 are 67% similar to the protein from S.pneumoniae (gi|15901070|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0496 (1e-169).","

InterPro
IPR003753
Family

Exonuclease VII, large subunit
PF02601	$\"[194-369]T$	Exonuc_VII_L
TIGR00237	$\"[6-438]T$	xseA

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[27-101]T$	tRNA_anti

noIPR
unintegrated

unintegrated
SSF50249	$\"[26-83]T$	Nucleic_acid_OB
SSF69075	$\"[255-352]T$	SSF69075

","BeTs to 7 clades of COG1570COG name: Exonuclease VII, large subunitFunctional Class: LThe phylogenetic pattern of COG1570 is ------v-ebrhUj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB003753 (Exonuclease VII, large subunit) with a combined E-value of 3.6e-87. IPB003753A 25-60 IPB003753B 61-94 IPB003753C 110-148 IPB003753D 184-216 IPB003753E 217-257 IPB003753F 266-316 IPB003753G 362-406","Residues 14-221 are 73% similar to a (LARGE VII SUBUNIT EXONUCLEASE) protein domain (PD013688) which is seen in EX7L_LACLA.Residues 264-432 are 30% similar to a (LARGE VII SUBUNIT EXONUCLEASE) protein domain (PD398498) which is seen in EX7L_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 16:22:36 2002","Mon Jan 14 14:53:02 2002","Thu Oct 10 16:22:12 2002","Thu Dec 6 10:42:42 2001","Thu Dec 6 10:42:42 2001","Thu Dec 6 10:42:42 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0527 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 14:54:21 2002","","No significant hits to the NCBI PDB database.","SMU.580","","Residues 27 to 101 (E-value = 6e-07) place SMu0527 in the tRNA_anti family which is described as OB-fold nucleic acid binding domain (PF01336)Residues 194 to 369 (E-value = 8.7e-39) place SMu0527 in the Exonuc_VII_L family which is described as Exonuclease VII, large subunit (PF02601)","Thu Dec 6 10:42:42 2001","24379058","","","","","Thu Dec 6 10:55:52 2001","1","","","SMU.580","63" "SMu0528","542717","542938","222","ATGTCAAACAAGAAGAAAACATTTGAAGAAAATTTACAGGATTTAGAAGAAATTGTGAACCAGTTAGAAACCGGTGAAATTCCTCTTGAAGAAGCTATTACTCAATTCCAAAAAGGAATGGCGCTTTCTAAAGATTTGCAGAAAACCTTGGAGTCTGCTGAAAAGACCTTGGTCAAAGTCATGCAGGCTGATGGCAGTGAAGCAGAAATGGACGAGTTGTGA","4.10","-9.00","8228","MSNKKKTFEENLQDLEEIVNQLETGEIPLEEAITQFQKGMALSKDLQKTLESAEKTLVKVMQADGSEAEMDEL","542935","For other 'xse' genes see SMu0527 (xseA) For exodeoxyribonuclease VII, large subunit see SMu0527. From Genbank [gi:13637902] This protein bidirectionally degradessingle-stranded DNA into large acid-insoluble oligonucleotides which are then degraded further into small acid-soluble oligonucleotides. ","exodeoxyribonuclease VII, small subunit","Cytoplasm","Several matches in gapped BLAST to exodeoxyribonuclease VII (smallsubunit) proteins:residues 3-72 are 75% similar to the enzyme inS.pyogenes (gi|15675403|).Residues 3-71 are 66% similar to the protein from S.pneumoniae (gi|15901069|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0497 (4e-24).","

InterPro
IPR003761
Family

Exonuclease VII, small subunit
PD028235	$\"[8-62]T$	Exonuc_VII_S
PF02609	$\"[6-69]T$	Exonuc_VII_S
TIGR01280	$\"[4-72]T$	xseB

","BeTs to 4 clades of COG1722COG name: Exonuclease VII small subunitFunctional Class: LThe phylogenetic pattern of COG1722 is ------v-ebrh--------xNumber of proteins in this genome belonging to this COG is 1","***** IPB003761 (Exonuclease VII, small subunit) with a combined E-value of 8.1e-20. IPB003761 7-60","Residues 8-68 are 52% similar to a (SMALL SUBUNIT EXONUCLEASE VII) protein domain (PD028235) which is seen in EX7S_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 16:23:34 2002","Mon Jan 14 14:55:57 2002","Thu Oct 10 16:23:34 2002","Thu Dec 6 10:55:28 2001","Thu Dec 6 10:55:28 2001","Thu Dec 6 10:55:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0528 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 14:56:58 2002","","No significant hits to the NCBI PDB database.","SMU.581","","Residues 6 to 69 (E-value = 1e-27) place SMu0528 in the Exonuc_VII_S family which is described as Exonuclease VII small subunit (PF02609)","Thu Dec 6 10:55:28 2001","24379059","","","Vales LD, Rabin BA, Chase JW.Subunit structure of Escherichia coli exonuclease VII.J Biol Chem. 1982 Aug 10;257(15):8799-805.PMID: 6284744 ","","Thu Dec 6 11:07:15 2001","1","","","SMU.581","903" "SMu0529","542935","543804","870","GTGAAAGATAAGATTAAATCCATTAATCAGGCTATTAAGCATTATTATGCGCAAACTCATGTGTCTCAGGATTTGATTGAAGCGGTCTTGTATTCTGTTGATGCAGGCGGTAAACGGATTCGTCCTCTCTTACTATTGGAAATCTTGCAAGGCTTTGGTTTGGTACTTACAGAAGCTCACTATCAGGTGGCAGCAAGTCTAGAGATGATTCATACCGGCAGCCTCGTTCATGATGACCTGCCTGCTATGGATAATGATGATTATAGGCGGGGACAGCTGACCAATCATAAGAAATTTGGTGAAGCGACAGCTATCTTGGCAGGTGACAGTCTTTTTCTAGACCCTTTTGGTTTGCTAGCCAAGGCGGACTTAAGGGCTGATATCAAGATAAAATTAGTAGCAGAATTGTCAGATGCTGCAGGAAGCTATGGTATGGTCGGTGGGCAAATGTTGGATATTAAGGGTGAACATGTTCAACTCAATTTAGACCAACTAGCTCAAATTCATGCCAATAAGACAGGAAAACTCTTGACTTTTCCTTTTGTAGCCGCAGGAATAATAGCAGAATTATCAGAAAAAGCCCTTGCTCGGCTCCGTCAGGTGGGTGAATTAGTTGGTTTGGCTTTTCAAGTACGTGATGATATTTTAGATGTGACAGCTAGTTTTTCAGAACTTGGTAAGACCCCACAAAAGGATATCGAAGCTGATAAATCAACCTATCCCAGTCTTTTGGGCTTGGACAAGTCCTATGCCATTTTGGAAGATTCTCTCAATCAAGCGCAAGCTATTTTCCAAAAATTAGCTTTAGAGGAACAATTTAATGCTACTGGAATTGAAACAATAATAGAAAGGTTGCGTCTCCATGCCTAA","5.40","-7.82","31616","MKDKIKSINQAIKHYYAQTHVSQDLIEAVLYSVDAGGKRIRPLLLLEILQGFGLVLTEAHYQVAASLEMIHTGSLVHDDLPAMDNDDYRRGQLTNHKKFGEATAILAGDSLFLDPFGLLAKADLRADIKIKLVAELSDAAGSYGMVGGQMLDIKGEHVQLNLDQLAQIHANKTGKLLTFPFVAAGIIAELSEKALARLRQVGELVGLAFQVRDDILDVTASFSELGKTPQKDIEADKSTYPSLLGLDKSYAILEDSLNQAQAIFQKLALEEQFNATGIETIIERLRLHA","543801","For other 'isp' genes see SMu1813 (ispE).","farnesyl diphosphate synthase (geranyltranstransferase)","Cytoplasm","Several matches in gapped BLAST to geranyltranstransferase (farnesyl diphosphate synthase) proteins: residues 3-289 are63% similar to the enzyme in S.pyogenes (gi15675402). Residues 2-288 are 58% similar to the protein from S.pneumoniae (gi15903130).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0498 (1e-100).","

InterPro
IPR000092
Family

Polyprenyl synthetase
PTHR12001	$\"[1-286]T$	GERANYLGERANYL PYROPHOSPHATE SYNTHASE
PF00348	$\"[25-281]T$	polyprenyl_synt
PS00444	$\"[205-217]T$	POLYPRENYL_SYNTHET_2
PS00723	$\"[75-91]T$	POLYPRENYL_SYNTHET_1

noIPR
unintegrated

unintegrated
G3DSA:1.10.600.10	$\"[5-289]T$	no description
PTHR12001:SF8	$\"[1-286]T$	GERANYL GERANYL PYROPHOSPHATE SYNTHASE

","BeTs to 16 clades of COG0142COG name: Geranylgeranyl pyrophosphate synthaseFunctional Class: HThe phylogenetic pattern of COG0142 is AmtkYQVCEBRHUJ--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000092 (Polyprenyl synthetase) with a combined E-value of 1e-34. IPB000092A 36-45 IPB000092B 67-78 IPB000092C 81-96 IPB000092D 148-153 IPB000092E 205-227","Residues 25-178 are 48% similar to a (SYNTHASE SYNTHETASE PYROPHOSPHATE TRANSFERASE) protein domain (PD000572) which is seen in Q9CNA1_PASMU.Residues 118-187 are 58% similar to a (SYNTHASE PROTEOME TRANSFERASE FPP) protein domain (PD413214) which is seen in Q9CH81_LACLA.Residues 195-248 are 59% similar to a (SYNTHASE SYNTHETASE TRANSFERASE DIPHOSPHATE) protein domain (PD003059) which is seen in Q9SBR3_MENPI.Residues 139-183 are 55% similar to a (SYNTHASE TRANSFERASE) protein domain (PD410808) which is seen in Q9K969_BACHD.Residues 185-246 are 35% similar to a (PROTEOME COMPONENT COMPLETE POLYPRENYL) protein domain (PD387055) which is seen in Q9CBA5_MYCLE.Residues 191-271 are 49% similar to a (SYNTHASE PYROPHOSPHATE GERANYLGERANYL) protein domain (PD169539) which is seen in Q9CH81_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 11:30:22 2006","Mon Jan 14 14:58:21 2002","Thu Sep 7 11:30:22 2006","Thu Dec 6 11:08:38 2001","Thu Dec 6 11:08:38 2001","Thu Dec 6 11:08:38 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0529 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 14 15:00:23 2002","","No significant hits to the NCBI PDB database.","SMU.582","","Residues 25 to 281 (E-value = 2.4e-75) place SMu0529 in the polyprenyl_synt family which is described as Polyprenyl synthetase (PF00348)","Thu Dec 6 11:08:38 2001","24379060","","","Thompson K, Dunford JE, Ebetino FH, Rogers MJ.Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase.Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73.PMID: 11785983 Burke C, Croteau R.Interactions with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate.J Biol Chem. 2001 Dec 3 PMID: 11733504 ","","Mon Jan 14 15:00:23 2002","1","","","SMU.582","283" "SMu0530","543797","544624","828","ATGCCTAAGGAAAGAGTGGATGTTCTAGCCTATAAACAAGGACTGTTTAACACAAGAGAACAAGCCAAGCGAGGTGTTATGGCAGGTTTGGTTGTCAATGTCATCAATGGAGAACGTTATGATAAACCCGGCGAGAAAATTGATGAAGCGACTGAGTTAAAGTTAAAGGGAGACAAATTAAAATATGTCAGTCGCGGCGGTTTGAAATTGGAAAAAGCATTAAAAGTTTTTGTCATTTCAGTAGATGGACAGATAACTTTGGACATTGGCGCTTCAACGGGTGGTTTTACAGACGTCATGCTGCAAAATGGTGCTCAATTAGTCTATGCTGTTGATGTTGGAACCAATCAGTTGGTGTGGAAATTACGTCAAGACGAACGCGTCTGCAGCATGGAACAGTACAATTTCCGCTATGCAGAGCCTAGCGATTTTGAACGAGGACAGCCAACTTTTGCTTCCATTGATGTGAGTTTTATTTCACTTAATTTAATATTACCAGCCTTATCTAAGATTTTAACAGATGGTGGTCAAGTTGTTGCTTTAATTAAACCGCAATTTGAGGCAGGTCGTGAACAGATTGGTAAGCATGGTATTGTTAAGGACAAGTCAGTCCACGAAACTGTTTTGGAGACAGTAACAACTTTTGCGACAAATTACGGATTCACAGTTAAAGAACTTGATTTTTCTCCTATTCAGGGCGGTCATGGCAATATTGAATTTTTAGCCTATTTAGAAAAATCAGCTCAAGCCCAAAATCAAGTCTTGACTAAGATTAAATCGATTGTTGAACAAGCACATAAGGAATTTAAAAAGAATGAAGAAACGTGA","7.00","0.00","30532","MPKERVDVLAYKQGLFNTREQAKRGVMAGLVVNVINGERYDKPGEKIDEATELKLKGDKLKYVSRGGLKLEKALKVFVISVDGQITLDIGASTGGFTDVMLQNGAQLVYAVDVGTNQLVWKLRQDERVCSMEQYNFRYAEPSDFERGQPTFASIDVSFISLNLILPALSKILTDGGQVVALIKPQFEAGREQIGKHGIVKDKSVHETVLETVTTFATNYGFTVKELDFSPIQGGHGNIEFLAYLEKSAQAQNQVLTKIKSIVEQAHKEFKKNEET","544621","","probable hemolysin A","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical and to putative hemolysin proteins: residues 1-274 are77% similar to putative hemolysin in S.pyogenes (gi15675401). Residues 1-270 are 75% similar to the protein from S.pneumoniae (gi15903129).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0499 (1e-124).","

InterPro
IPR002877
Domain

Ribosomal RNA methyltransferase RrmJ/FtsJ
PF01728	$\"[62-248]T$	FtsJ

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[4-53]T$	S4
SM00363	$\"[4-71]T$	S4
PS50889	$\"[4-67]T$	S4

InterPro
IPR004538
Family

Hemolysin A
TIGR00478	$\"[5-239]T$	tly

noIPR
unintegrated

unintegrated
SSF53335	$\"[18-237]T$	SSF53335

","BeTs to 9 clades of COG1189COG name: Predicted rRNA methylasesFunctional Class: JThe phylogenetic pattern of COG1189 is a----qvc-br-uj--o---xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 5-127 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD105169) which is seen in O28099_ARCFU.Residues 3-60 are 56% similar to a (PROTEOME COMPLETE FOLD-AHRC) protein domain (PD412179) which is seen in Q9K972_BACHD.Residues 61-241 are 67% similar to a (COMPLETE PROTEOME HEMOLYSIN TLYA) protein domain (PD007579) which is seen in Q9CH80_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 16:25:14 2002","Thu Sep 7 11:41:11 2006","Thu Sep 7 11:41:11 2006","Thu Dec 6 11:23:24 2001","","Thu Dec 6 11:23:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0530 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 10 16:25:14 2002","","No significant hits to the NCBI PDB database.","SMU.583","","Residues 4 to 53 (E-value = 1.7e-05) place SMu0530 in the S4 family which is described as S4 domain (PF01479)","Thu Dec 6 11:23:24 2001","24379061","","","","","Thu Dec 6 15:48:08 2001","1","","","SMU.583","284" "SMu0531","544611","545075","465","ATGAAGAAACGTGAACGATTAGAATTAATTAAAAAAATTGTTTTAGAAAATGAAATTGAAACACAAAAAGAATTGGTCAAACTTTTAGAGAACGAAGGCTTACAAGCAACGCAAGCGACAATTTCCCGTGATATTAATGAGGTCGGTATCATTAAAGTACCAGCTTCAAATAGTCGCTATATTTATGGCCTTTCTAAGGAAATAAGCAAAAAAGAAGAGTCAACACCAAAACCAGCTGAAAAAGCAGTTAAGTTTATTTCAGATCAGGTGGCAGGTTTAGAGCATCTCATTCATATTGATGTTGTTCCTGGAAATAGCTATTTATTGAAACGTTTTTTACTAGAGAGATTTGAAGGACTTATTTTTAGCTTGCTGGCAGATGATGACAGTTTGCTTTTGATTGTTAAAAATGCTAAAGATAGTGATAGAATTCGTCAAGAAATCAAATCTTGGATGGCCAATTAA","7.70","0.49","17572","MKKRERLELIKKIVLENEIETQKELVKLLENEGLQATQATISRDINEVGIIKVPASNSRYIYGLSKEISKKEESTPKPAEKAVKFISDQVAGLEHLIHIDVVPGNSYLLKRFLLERFEGLIFSLLADDDSLLLIVKNAKDSDRIRQEIKSWMAN","545072","For other 'arg' genes see SMu0512 (argF); SMu0605 (argC); SMu0606 (argJ);SMu0607 (argB); SMu0608 (argD);SMu1904 (argS); SMu1903 (argR);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH). From Genbank: [gi:8134308]This protein regulates arginine biosynthesis genes and activates arginine deiminase pathway genes.","arginine repressor","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator of arginine metabolism expression: residues 1-152 are 49% similar to putative repressor protein in S.pyogenes (gi15675400). Residues 1-151 are 34% similar to the protein from S.pneumoniae (gi15901066).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0500 (7e-33).","

InterPro
IPR001669
Family

Arginine repressor
PR01467	$\"[21-34]T$ $\"[37-52]T$ $\"[91-104]T$ $\"[121-136]T$	ARGREPRESSOR
PF01316	$\"[1-70]T$	Arg_repressor
PF02863	$\"[85-151]T$	Arg_repressor_C
SSF55252	$\"[82-152]T$	Arg_repress

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-67]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[3-78]T$	SSF46785

","BeTs to 5 clades of COG1438COG name: Arginine repressorFunctional Class: EThe phylogenetic pattern of COG1438 is ------v-ebrh-------n-Number of proteins in this genome belonging to this COG is 3","***** PR01467 (Bacterial arginine repressor signature) with a combined E-value of 1.3e-11. PR01467A 21-34 PR01467B 37-52 PR01467D 121-136","Residues 1-109 are 35% similar to a (REPRESSOR ARGININE TRANSCRIPTION) protein domain (PD007402) which is seen in Q9ZEV1_BACST.Residues 1-144 are 34% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD398165) which is seen in Q9CH79_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 11:09:04 2006","Wed Jan 16 08:12:39 2002","Thu Sep 7 11:09:04 2006","Thu Dec 6 15:49:00 2001","Thu Dec 6 15:49:00 2001","Thu Dec 6 15:49:00 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0531 is paralogously related (blast p-value < 1e-3) to SMu1900, a predicted arginine repressor (arginine catabolic regulator).","Wed Jan 16 08:12:39 2002","Thu Sep 7 11:09:04 2006","pdb1B4AA Chain A, Structure Of The Arginine Repressor From Ba... 71 5e-014","SMU.584","","Residues 1 to 70 (E-value = 2e-26) place SMu0531 in the Arg_repressor family which is described as Arginine repressor, DNA binding domain (PF01316)","Thu Dec 6 15:49:00 2001","24379062","","","Maghnouj,A., de Sousa Cabral,T.F., Stalon,V. and Vander Wauven,C.The arcABDC gene cluster, encoding the arginine deiminase pathwayof Bacillus licheniformis, and its activation by the argininerepressor argRJ. Bacteriol. 180 (24), 6468-6475 (1998)PubMed: 9851988North,A.K., Smith,M.C. and Baumberg,S.Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli argininerepressorGene 80 (1), 29-38 (1989)PubMed: 2507400Czaplewski,L.G., North,A.K., Smith,M.C., Baumberg,S. andStockley,P.G.Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilisMol. Microbiol. 6 (2), 267-275 (1992)PubMed: 1312212","","Thu Dec 6 15:57:45 2001","1","","","SMU.584","904" "SMu0532","545092","546750","1659","ATGCTTTTAGAAATTGCCATTAAAAATTTTGCTATTATTGAAGAAATCTCACTCAATTTTGAAAGGGGAATGACTGTTCTGACCGGTGAAACAGGTGCAGGGAAGTCTATTGTCATTGATGCCATGAATATGATGCTAGGCAGTAGAGCCAGCATAGATGTCATTCGTCATGGTAGTCCTAAAGCAGAGATTGAGGGTTTTTTCTCTGTGGATAAAAATCCTTCTTTAGAGCAGTTACTGGCTGATCAGGGAATTGCTTTTTCAGATGAGCTAATCATTCGCCGTGAGATTTTACAAAATGGTCGCAGTATTAGTCGTATCAATGGTCAAATGGTTAATCTGGCAACTCTGCGTGCCGTTGGGCAGTATTTAGTTGATATTCATGGACAGCATGATCAAGAAGAACTGATGCGGCCGCAAAAGCATATTCAGTTGTTGGATGAATTTGGTGATGAGGTATTTCAGGTAAGCAAGCAGCATTATCAGGACTTATTTGACCACTATCGGGACTTACGTAAGCGCGTCTTGAATAAACGTAAGAATGAGCAAGAACATCAAGCACGTATTGAAATGCTGGAGTATCAGATAGGAGAGATTGAAGCAGCAAACTTACAATCTGGTGAGGATACCAAGCTCTTAAAACAACGTGATAAACTTATGAATCATAAGCTTATTGTTGATACCTTAACCAATGCTTATGTTTTACTTGATAATGAAGATTTTTCGAGTTTGACCAATGTTCGTTCAGCTATGAATGATTTGCAGAGTTTGGAAGAATATGATGCTGAGTACAAGGATTTATCCAATAATCTCAGCGAATCTTACTATATTTTAGAAGATGTTAGCAAACGTCTAGAGACTATACTGGATCATATGGATTTTGATGCCAATACTTTGGTTAAACTTGAAGCACGTCTTGATGTTATCAACACCATCACGCGTAAGTATGGTGGTTCAGTTGATGATGTTTTGGCTTATTTTGACAATATCAGTAAGGAATACAATCATTTGACGGTAAATGACCTCGCTTTTGATGATATGGAAAGAGAACTAAAAGTTTTGGAGCGCTCACTATTAGAAGCAGCAGCTCAATTGAGTCAAAAACGCCATGCCATTGCGGAAACCTTGTCTCAGGAGATTAAGCAGGAACTAAAAGATCTCTACATGGATAAGGCTGATTTTAAAGTTGTTTTTACTAAAGGAAAATTTAATCGCGAGGGAAATGAAACAGTCGCTTTCCATATTTCGACTAATCCTGGCGAAGACTTTAAGCCTTTGGTCAAAGTCGCTTCTGGTGGAGAGCTGTCTCGTCTCATGTTAGCCATTAAGTCAGCTTTTTCACGTCGTGAAGATAAGACTAGCATTGTTTTTGATGAAGTTGATACAGGTGTTTCAGGACGTGTCGCTCAGGCTATTGCTCAAAAAATTTACAAAATAGGCAATCACGGTCAAGTTTTAGCTATTTCCCATATCCCGCAAGTCATTGCCATCAGTGATTATCAGTACTTTATTGAAAAACAAAGCAGCAAAGCCACAACTGTCTCAACGGTTCGCCTTTTAAATCAAGAGGAAAGAATTGAAGAAATCGCTAAGATGTTGGCAGGGGATAATGTGACCCAAGCTGCGCGCCAGCAAGCTAAAGAACTATTAAAAAAATAA","5.20","-17.55","62730","MLLEIAIKNFAIIEEISLNFERGMTVLTGETGAGKSIVIDAMNMMLGSRASIDVIRHGSPKAEIEGFFSVDKNPSLEQLLADQGIAFSDELIIRREILQNGRSISRINGQMVNLATLRAVGQYLVDIHGQHDQEELMRPQKHIQLLDEFGDEVFQVSKQHYQDLFDHYRDLRKRVLNKRKNEQEHQARIEMLEYQIGEIEAANLQSGEDTKLLKQRDKLMNHKLIVDTLTNAYVLLDNEDFSSLTNVRSAMNDLQSLEEYDAEYKDLSNNLSESYYILEDVSKRLETILDHMDFDANTLVKLEARLDVINTITRKYGGSVDDVLAYFDNISKEYNHLTVNDLAFDDMERELKVLERSLLEAAAQLSQKRHAIAETLSQEIKQELKDLYMDKADFKVVFTKGKFNREGNETVAFHISTNPGEDFKPLVKVASGGELSRLMLAIKSAFSRREDKTSIVFDEVDTGVSGRVAQAIAQKIYKIGNHGQVLAISHIPQVIAISDYQYFIEKQSSKATTVSTVRLLNQEERIEEIAKMLAGDNVTQAARQQAKELLKK","546747","For other 'rec' genes see SMu0021 (recO);SMu0545 (recM); SMu0545 (recR); SMu1956 (recF); SMu1892 (recA); SMu0425 (recU) ; SMu1669 (recG); SMu1705 (recD) and SMu1339 (recJ). From Genbank: [gi:132256]This protein may be involved in recombinational repair of damaged DNA.","DNA repair and genetic recombination protein","Cytoplasm","Several matches in gapped BLAST to DNA repair and genetic recombination proteins: residues 1-551 are 72% similar to the protein in S.pneumoniae (gi15903127).Residues 1-552 are 69% similar to the protein in S.pyogenes (gi15675399). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0501 (0.0).","

InterPro
IPR003395
Domain

SMC protein, N-terminal
PF02463	$\"[1-513]T$	SMC_N

InterPro
IPR004604
Family

DNA repair protein RecN
TIGR00634	$\"[1-552]T$	recN

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-183]T$ $\"[404-533]T$	G3DSA:3.40.50.300
PTHR18937	$\"[20-114]T$	PTHR18937
PTHR18937:SF10	$\"[20-114]T$	PTHR18937:SF10
SSF52540	$\"[2-506]T$	SSF52540

","BeTs to 8 clades of COG0497COG name: ATPases involved in DNA repairFunctional Class: LThe phylogenetic pattern of COG0497 is -----q-cebrhuj---l--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 94-149 are 50% similar to a (REPAIR DNA COMPLETE PROTEOME) protein domain (PD036511) which is seen in Q9CNU3_PASMU.Residues 165-387 are 32% similar to a (REPAIR DNA ATP-BINDING RECOMBINATION) protein domain (PD008454) which is seen in RECN_BACSU.Residues 1-149 are 42% similar to a (DNA REPAIR ATP-BINDING RECOMBINATION) protein domain (PD348650) which is seen in RECN_VIBCH.Residues 49-152 are 34% similar to a (REPAIR DNA ATP-BINDING RECN) protein domain (PD395165) which is seen in RECN_SYNY3.Residues 165-387 are 36% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in Q9CH78_LACLA.Residues 389-550 are 72% similar to a (REPAIR DNA ATP-BINDING RECOMBINATION) protein domain (PD033003) which is seen in Q9CH78_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 11:58:24 2006","Thu Jul 27 10:18:28 2006","Thu Jul 27 10:18:28 2006","Thu Dec 6 12:57:15 2001","","Thu Dec 6 12:57:15 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0532 is paralogously related (blast p-value < 1e-3) to SMu1375, a predicted chromosome segregation SMC protein.","Wed Apr 3 09:10:24 2002","","No significant hits to the NCBI PDB database.","SMU.585","","Residues 1 to 151 (E-value = 6.8e-06) place SMu0532 in the SMC_N family which is described as RecF/RecN/SMC N terminal domain (PF02463)","Thu Dec 6 12:57:15 2001","24379063","","","Van Hoy,B.E. and Hoch,J.A.Characterization of the spoIVB and recN loci of Bacillus subtilisJ. Bacteriol. 172 (3), 1306-1311 (1990)PubMed: 2106508","","Thu Dec 6 13:09:30 2001","1","","","SMU.585","64" "SMu0533","546972","547811","840","ATGAGTAAAATTAAAATTGTAACTGATTCTTCTATTACAATCGAGCCCGATTTAGTTGAAGCATTGGATATCACTGTTGTTCCTTTAACCGTTATGGTTGACGGCATTGTTTATTCTGATAACGATCTTAAGGAAGATGGGAAATTTCTTTCTTTAATGCGAAACAGTAAGTCACTCCCTAAAACAAGCCAACCACCTGTTGGTCTGTTCGCAGAAACTTATGAAAAGCTTATTAAAGAGGGGGCGGAACAAATTGTTGCTATTCATATTACCCATTCCTTATCTGGAACACTTGAGGCCTCACGTCAAGGAGCTAATATTGCTGGAGCAGATGTCACTGTATTAGACTCTGCCTTTACAGATCAAGCCATGAAATTTCAAGTTATTGCGGCTGCTAAACTAGCTCAAAAGGGTAGCAGTCTAGAAGAAATTTTGGCAAGGGTTGAAGAAGTAAAAAAGAAAACCGAACTTTTTATTGGTGTCTCAACCTTAGAAAATCTGGTTAAAGGTGGACGAATTGGCCGTGTGACAGGCTTAATCAGTTCTCTTCTCAATATCAGAGTTGTTATGGAACTGAAAAACCATGATCTTAATCCTATTGCGAAAGGACGCGGTAATAAAACGTTTAACAAATGGCTGGATAATTTGATTGCGACTATCAAAGACCGCAAAATTGCTGAGATCGGCATTTCCTATGCTGGGACTTCAGATTTTGCTAATGGTCTTAAAGACAAGTTACAAGCTTATGTTGAGAAAGATATTGCTGTTTTAGAAACGGGGTCAATTATTCAGACTCATACAGGTGAAGGTGCTTTTGCAGTAATGGTGCATTATGAGTAA","6.10","-2.78","30226","MSKIKIVTDSSITIEPDLVEALDITVVPLTVMVDGIVYSDNDLKEDGKFLSLMRNSKSLPKTSQPPVGLFAETYEKLIKEGAEQIVAIHITHSLSGTLEASRQGANIAGADVTVLDSAFTDQAMKFQVIAAAKLAQKGSSLEEILARVEEVKKKTELFIGVSTLENLVKGGRIGRVTGLISSLLNIRVVMELKNHDLNPIAKGRGNKTFNKWLDNLIATIKDRKIAEIGISYAGTSDFANGLKDKLQAYVEKDIAVLETGSIIQTHTGEGAFAVMVHYE","547808","","conserved hypothetical protein, DevG family","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins:residues 1-278 are 69% similar to S.pneumoniae (gi15903063).Residues 1-279 are 71% similar to the protein from S.pyogenes (gi15675397).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0502 (1e-116).","

InterPro
IPR003797
Family

DegV
PF02645	$\"[73-279]T$	DegV
TIGR00762	$\"[4-279]T$	DegV

noIPR
unintegrated

unintegrated
G3DSA:3.30.1180.10	$\"[154-276]T$	G3DSA:3.30.1180.10
SSF82549	$\"[1-279]T$	SSF82549

","BeTs to 4 clades of COG1307COG name: Uncharacterized protein, DegV familyFunctional Class: SThe phylogenetic pattern of COG1307 is ------V--Br---GP-----Number of proteins in this genome belonging to this COG is 3","***** IPB003797 (DUF194) with a combined E-value of 3.2e-12. IPB003797A 62-98 IPB003797C 170-192 IPB003797D 258-268","Residues 6-140 are 60% similar to a (PROTEOME COMPLETE PLASMID MG326) protein domain (PD007382) which is seen in Q9CI68_LACLA.Residues 196-279 are 50% similar to a (PROTEOME COMPLETE YEJH) protein domain (PD392108) which is seen in Q9CI68_LACLA.Residues 143-194 are 59% similar to a (PROTEOME COMPLETE DEGV YEJH) protein domain (PD348894) which is seen in Q9CI68_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 11:49:23 2006","Thu Sep 7 11:49:23 2006","Thu Sep 7 11:49:23 2006","Thu Dec 6 13:14:45 2001","Thu Dec 6 13:14:45 2001","Thu Dec 6 13:14:45 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0533 is paralogously related (blast p-value < 1e-3) to SMu0820 and SMu0148, both predicted conserved hypothetical proteins.","Thu Sep 7 11:49:23 2006","","No significant hits to the NCBI PDB database.","SMU.586","","Residues 73 to 279 (E-value = 4.6e-68) place SMu0533 in the DUF194 family which is described as Uncharacterized protein, DegV family COG1307 (PF02645)","Thu Dec 6 13:14:45 2001","24379064","","","","","","1","","","SMU.586","285" "SMu0534","547804","548661","858","ATGAGTAAAAAAATTCCTAAAGGACCTGCTTTCTTTCTTGCAAATCTTCTTATTTTTAGCTTATTATTTTATTTTTTTATTCCAACAGCGAAGTTATCTTTTAAAAATAGCGATCAGAAATCTTCATTAAACAAATCCAAAGCGACATCTTTTCACTATATTGCTATCGGTGACTCTTTGACACAAGGAGTCGGTGATACGACTGATCAAGGCGGCTTTATTCCCCTTTTATCGCAAGAGTTGAAATCAAATTATCACTATAATGTTTTAAGCAGTAATTATGGTGTTTCAGGCAATACAAGCCAGCAAATTTTGATACGGATGCGAAAAGAGAGAAAAATTCAAAAAAGTTTGAATAAGGCTAATTTAATGACCTTAACAGTTGGTGGAAATGATGTTATGACTGTTGTTCGAAAGGGATTAACAAACTTAAAAGTATCTTCTTTTAGGCAGCCAGCTAAAACTTATCAGAAGCATTTGCGAAAAATTATCCAGATGGCTAGAAGAAGGAATAAGGATCTCCCCATTTATATCATTGGTATTTACAATCCTTATTATTTAAATTTCCCTAATATGACGCAAATGCAGGATATTATTGACAATTGGAATAAGGGAACGCAAAAGGTTGTCGCAGAGTATAGAAACGTTTATTTTGTTCCCATAAACGATTTACTTTATAAAGGTGTTAATGGGGAGCAAAAGGCTGTTGGAACATCTGACAGTGAGGCAGAGTCAGGAGAAGTAACCAATGATGCCCTTTCTGAAGGAGATCGTTTCCATCCTAATAATGTTGGTTATCAAATCATGTCAAAAGCAATAATGGAGAAAATCAGTGAAACAAAGAAGAACTGGAAATAA","10.60","17.96","32309","MSKKIPKGPAFFLANLLIFSLLFYFFIPTAKLSFKNSDQKSSLNKSKATSFHYIAIGDSLTQGVGDTTDQGGFIPLLSQELKSNYHYNVLSSNYGVSGNTSQQILIRMRKERKIQKSLNKANLMTLTVGGNDVMTVVRKGLTNLKVSSFRQPAKTYQKHLRKIIQMARRRNKDLPIYIIGIYNPYYLNFPNMTQMQDIIDNWNKGTQKVVAEYRNVYFVPINDLLYKGVNGEQKAVGTSDSEAESGEVTNDALSEGDRFHPNNVGYQIMSKAIMEKISETKKNWK","548658","","lipase/acylhydrolase with GDSL-like domain","Periplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 39-285 are 51% similar to S.pyogenes (gi15675396) and residues 28-284 are 48% similar to the protein from S.thermophilus (gi1850894).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0503 (1e-68).","

InterPro
IPR001087
Family

Lipolytic enzyme, G-D-S-L
PF00657	$\"[53-273]T$	Lipase_GDSL

InterPro
IPR013830
Domain

Esterase, SGNH hydrolase-type
SSF52266	$\"[47-277]T$	Esterase_SGNH_hydro-type

InterPro
IPR013831
Domain

Esterase, SGNH hydrolase-type, subgroup
G3DSA:3.40.50.1110	$\"[47-273]T$	Esterase_SGNH_hydro-type_subgr

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 53-273 are 38% similar to a (PROTEOME HRD4-2 COMPLETE ILVA) protein domain (PD358926) which is seen in Q9CI67_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 14:01:12 2006","Tue Aug 29 14:01:12 2006","Tue Aug 29 14:01:12 2006","Thu Dec 6 13:22:54 2001","","Thu Dec 6 13:22:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0534 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Aug 29 14:01:12 2006","","No significant hits to the NCBI PDB database.","SMU.587","","Residues 53 to 273 (E-value = 3.5e-21) place SMu0534 in the Lipase_GDSL family which is described as GDSL-like Lipase/Acylhydrolase (PF00657)","Thu Dec 6 13:22:54 2001","24379065","","","","","","1","","","SMU.587","536" "SMu0535","548636","549235","600","GTGAAACAAAGAAGAACTGGAAATAAAAAAAATTGGTGGAAATGGGCTTTTCTGCTTTTATTAGCACTCAATATTGCTTTTTGGGGAGTGATTATCAGTCGTGTTTTGAGCGGTTACCATTCTAATACAATAACAAGTCAAACAGTAAAAAATCCTGTTAAGGTTGGAACAATTACGACAACTAAAGAACAATTGAATCAGACCTTGGCAAGTTATTTGAATGATTATCAGTCTAAGGGTATGACCTACAGTGTTCAACTAACTTCAACAAACATTGAATTTCAAGGAACTTATAAACTTCTAGGTTATAACGTGCCTCTTTATATCTATTTTGAACCTTATCAGTTAAAAAGCGGAGCTGTCCAGCTTAAAGTGACTTCCTTTTCAGTAGGCAATCTTCCTCTGCCAGCATCAGAGGTTCTTAGTTATATTAAATCAAGTTACAAACTGCCAAATTTTGTTGATGTTATTCCAGAGAAGTCTGTTGTTAATATCAATTTGCAAAAAATAGACAATGATGCAGGTATCTATTTAAAGTCAACAGCTATAAATTTGGTTAGTGATGAAATAAACTTTGATATTTTAAAGAAAAAACGTTAA","10.50","11.22","22525","MKQRRTGNKKNWWKWAFLLLLALNIAFWGVIISRVLSGYHSNTITSQTVKNPVKVGTITTTKEQLNQTLASYLNDYQSKGMTYSVQLTSTNIEFQGTYKLLGYNVPLYIYFEPYQLKSGAVQLKVTSFSVGNLPLPASEVLSYIKSSYKLPNFVDVIPEKSVVNINLQKIDNDAGIYLKSTAINLVSDEINFDILKKKR","549232","","conserved hypothetical protein","Membrane, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 30-197 are 57% similar to S.pyogenes (gi|15675395|) and 40% similar to residues 30-197 from Lactococcus lactis subsp. lactis (gi|15675395|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0504 (1e-56).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-33]?$	signal-peptide
tmhmm	$\"[15-35]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 30-193 are 40% similar to a (COMPLETE PROTEOME YFAA BH1181) protein domain (PD035119) which is seen in Q9CI65_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 08:19:05 2002","Thu Dec 6 13:25:41 2001","Wed Jan 16 08:19:05 2002","Thu Dec 6 13:25:41 2001","","Thu Dec 6 13:25:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0535 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 08:19:05 2002","","No significant hits to the NCBI PDB database.","SMU.588","","No significant hits to the Pfam 11.0 database","Thu Dec 6 13:25:41 2001","24379066","","","","","","1","","","SMU.588","905" "SMu0536","549332","549607","276","ATGGCTAACAAACAAGATTTGATTGCAAAAGTAGCAGAAGCTACTGAATTGACTAAGAAAGATTCAGCTGCAGCAGTAGACGCTGTCTTCTCAGCAGTATCATCTTACCTTGCAAAGGGTGAAAAAGTACAACTTATTGGTTTTGGTAACTTTGAAGTTCGCGAACGTGCAGCACGCAAAGGTCGCAACCCTCAAACAGGTGAAGAAATCAAAATCAAAGCTTCTAAAGTTCCAGCATTCAAAGCTGGTAAAGCTCTTAAAGACGCTGTAAAATAA","10.60","6.99","9689","MANKQDLIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKGRNPQTGEEIKIKASKVPAFKAGKALKDAVK","549604","From Genbank:[gi:14194638]This protein belongs to the histone like family of prokaryotic DNA-binding proteins which are capable of wrapping DNA to stabilize it, and prevent its denaturation under extreme environmental conditions.It seems also to act as a fortuitous virulence factor in delayed sequelae by binding to heparan sulfate-proteoglycans in the extracellular matrix of target organs and acting as a nidus for in situ immune complex formation . ","histone-like DNA-binding protein","Cytoplasm, Periplasm","Matches in gapped BLAST to histone-like DNA-binding proteins :residues 1-91 are 83% similar to the previously published protein in S.mutans (gi|14194638|). Residues 1-91 are 76% similar to the protein from S.pneumoniae (gi|15900980|) and are 79% similar to the protein from S.sobrinus (gi|14194639|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0505 (4e-35).","

InterPro
IPR000119
Family

Histone-like bacterial DNA-binding protein
PD000945	$\"[11-91]T$	Bac_DNAbind
PR01727	$\"[41-56]T$ $\"[59-72]T$ $\"[75-89]T$	DNABINDINGHU
G3DSA:4.10.520.10	$\"[2-90]T$	Hist_DNA_bd_bac
PF00216	$\"[2-91]T$	Bac_DNA_binding
SM00411	$\"[2-91]T$	BHL
PS00045	$\"[47-66]T$	HISTONE_LIKE

InterPro
IPR010992
Family

IHF-like DNA-binding
SSF47729	$\"[1-91]T$	IHF_like_DNA_bnd

","BeTs to 11 clades of COG0776COG name: Histone-like DNA-binding proteinFunctional Class: LThe phylogenetic pattern of COG0776 is -----QvcEBrHujgpolinXNumber of proteins in this genome belonging to this COG is 1","***** IPB000119 (Bacterial histone-like DNA-binding protein) with a combined E-value of 3.8e-24. IPB000119 37-67","Residues 1-91 are 83% similar to a (DNA-BINDING REGULATION CONDENSATION HU FACTOR) protein domain (PD000945) which is seen in DBH_STRMU.Residues 3-91 are 40% similar to a (TRANSCRIPTION 3D-STRUCTURE REGULATION) protein domain (PD393742) which is seen in TF1_BPSP1.Residues 43-90 are 52% similar to a (DNA-BINDING REGULATION CONDENSATION INTEGRATION HOST) protein domain (PD404788) which is seen in DBH2_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 08:46:09 2002","Thu Dec 6 13:40:39 2001","Thu Oct 10 16:29:13 2002","Thu Dec 6 13:40:39 2001","Thu Dec 6 13:40:39 2001","Thu Dec 6 13:40:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0536 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 08:25:56 2002","Thu Dec 6 13:40:39 2001","pdb|1HUE|A Chain A, Histone-Like Protein >gi|1311346|pdb|1HUE|B... 113 6e-027pdb|1B8Z|A Chain A, Hu From Thermotoga Maritima >gi|7245987|pdb... 86 1e-018pdb|1IHF|B Chain B, Crystal Structure Of An Ihf-Dna Complex: A ... 63 9e-012","SMU.589","","Residues 2 to 91 (E-value = 2.4e-52) place SMu0536 in the Bac_DNA_binding family which is described as Bacterial DNA-binding protein (PF00216)","Thu Dec 6 13:40:39 2001","24379067","","Stinson,M.W., McLaughlin,R., Choi,S.H., Juarez,Z.E. and Barnard,J.Streptococcal histone-like protein: primary structure of hlpA andprotein binding to lipoteichoic acid and epithelial cellsInfect. Immun. 66 (1), 259-265 (1998)PubMed: 9423866Pubmed:9423866","Kano,Y., Osato,K., Wada,M. and Imamoto,F.Cloning and sequencing of the HU-2 gene of Escherichia coliMolecular & general genetics : MGG. 209 (2), 408-410 (1987)PubMed: 3312963Mende,L., Timm,B. and Subramanian,R.Primary structures of two homologous ribosome-associatedDNA-binding proteins of Escherichia coliFEBS letters. 96 (2), 395-398 (1978)PubMed: 215461Kohno,K., Wada,M., Kano,Y. and Imamoto,F.Promoters and autogenous control of the Escherichia coli hupA andhupB genesJournal of molecular biology. 213 (1), 27-36 (1990)PubMed: 2187099","Tue Mar 26 08:30:08 2002","Wed Jan 16 08:25:56 2002","1","","","SMU.589","906" "SMu0537","549899","549699","201","TTGCACCCTAAAAGTTGGACAGAAAATCTAACGATAGGGGTGTTTTTTGATGAAATTAACGTATATGAAAAGTCTTTCAAATCGCTCGACAAACTTGAAAAAGCCATCACTAACTACATTTTTGACTACAACAAGAAACGAATCAAGACAAAACTAAAAGGACTCAGCCCTGTGCAATACAGGACTAAATCCCTTCAATAA","10.50","6.22","7838","MHPKSWTENLTIGVFFDEINVYEKSFKSLDKLEKAITNYIFDYNKKRIKTKLKGLSPVQYRTKSLQ","549702","","transposase fragment","Cytoplasm, Extracellular","Matches in gapped BLAST to transposase:residues 22-64 are 96% similar to the previously published enzyme in S.mutans (gi3873218). Residues 22-64 are 76% similar to the protein from S.pneumoniae (gi8163693).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (3e-15).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[22-62]T$	rve

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 22-61 are 75% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in Q9KK23_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 08:32:19 2002","Wed Feb 9 14:33:01 2005","Wed Feb 9 14:33:01 2005","Thu Dec 6 13:58:12 2001","","Thu Dec 6 13:58:12 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0537 is paralogously related (blast p-value < 1e-3) to SMu0934,SMu1719, SMu1283,SMu1258, SMu0695, SMu0514, and SMu0395, all predicted transposases. ","Wed Jan 16 08:32:19 2002","","No significant hits to the NCBI PDB database.","SMU.590c","","No significant hits to the Pfam 11.0 database","Thu Dec 6 13:58:12 2001","24379068","","","Rubens,C.E., Heggen,L.M. and Kuypers,J.M.IS861, a group B streptococcal insertion sequence related to IS150and IS3 of Escherichia coliJ. Bacteriol. 171 (10), 5531-5535 (1989)PubMed: 2477359","","Thu Dec 6 14:04:02 2001","1","","9","SMU.590c","" "SMu0538","551145","550027","1119","ATGAAGAAAAAAGTTATTATTACAACAATAGCAGCCTTTTTATTTATTCTTTTTAGTGTAGGAGCCATTATTTTTACTATTGGAAAAACCGCTAATACCCAAACTAATATTCAATTAGAAAGAACTTCTTCAGACATCGAACACGCGTTATACTATGCTTCTTTCGCAGCTAATTCCCATAATACTCAGAGTTGGAAAGTTAATTTAGATCCTAAGCAAAAGAGATTAGGGGTTTTTCTGAATAATAAGCGTTCCTTAAATGTCGTTGACCCAAATAATCGAGAACTTTATATTTCAATTGGTTGTTATATTCAATCTCTAAAAAAATCATTCGAAGCTTATGGATATAATGTTAGCATTTCTAATATTGCTCCTTCTAAAGAAAACAAATATCAAGTTGTATTAATAAATTATCAAAAATTAAAAAATAATAAAATTAACAATAAACAATTGGATATCATCCAAAAACGTCATACTGATAAAAGAAAATTTCAGAAAAAACCAATTAATAGAACAGTCGTTTCAAGTTTAATTAAAAAATATAATAATGTTTACTACTATGCTAAGGGGAGTAAAACATTTAAATATCTACAAAAGGGGAGTCTCGCAGCTGCTGCTAAACAGTATAAAAATCAAGATTTTTTAAAAGAACAGGGAAAATGGTTGCGTTTTTCTAATCAAGAAGTTGAAAAAAAACAAGATGGTATCTCGGGTGATATGCTAGGGTTAAATCCTATAATTAAAACCCTTTATTATCTAACAAGTAATCATAAGAATGCCACGAGTAATAATTTTGTTAAACAGAGTAAGAATACTTTAATTAATCAAGTAGAGAACTGCGCAGGTTTTTTTGTAATTACAGGTGAACAGAATATTTCTAAATGGATTGCTGTTGGTGAAAAATCTCAAGCTTTCTGGTATGATTGTGTTAGAAATAACATTGCAGTTCAACCGATTAGTGCCATGATTGAAATTCCCTCCTATAATCAAAAGTTGCAGCAGAATTTAGGCAAATCACAACCTGTTCAATTAATTTTACGAGTAGGTTATGTTAACAGTTATGGTAAAAATGTTGGTCCTCGTCGAAATTTAAAAGATTATATTACTGTGAAAAAATAA","10.80","35.81","42592","MKKKVIITTIAAFLFILFSVGAIIFTIGKTANTQTNIQLERTSSDIEHALYYASFAANSHNTQSWKVNLDPKQKRLGVFLNNKRSLNVVDPNNRELYISIGCYIQSLKKSFEAYGYNVSISNIAPSKENKYQVVLINYQKLKNNKINNKQLDIIQKRHTDKRKFQKKPINRTVVSSLIKKYNNVYYYAKGSKTFKYLQKGSLAAAAKQYKNQDFLKEQGKWLRFSNQEVEKKQDGISGDMLGLNPIIKTLYYLTSNHKNATSNNFVKQSKNTLINQVENCAGFFVITGEQNISKWIAVGEKSQAFWYDCVRNNIAVQPISAMIEIPSYNQKLQQNLGKSQPVQLILRVGYVNSYGKNVGPRRNLKDYITVKK","550030","","conserved hypothetical protein","Extracellular","No significant hit to gapped BLAST found.SMu0538 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[5-25]?$	transmembrane_regions

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[16-29]T$ $\"[37-60]T$	HTHTETR
PF00440	$\"[16-62]T$	TetR_N
PS50977	$\"[10-70]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[1-79]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[3-62]T$	Homeodomain-rel

InterPro
IPR002481
Family

Ferric-uptake regulator
PD002003	$\"[40-149]T$	FUR
PF01475	$\"[24-143]T$	FUR

noIPR
unintegrated

unintegrated
SSF46785	$\"[16-148]T$	SSF46785

","BeTs to 10 clades of COG0735COG name: Ferric uptake regulation proteinFunctional Class: PThe phylogenetic pattern of COG0735 is a----QVCEBRhujgpo----Number of proteins in this genome belonging to this COG is 1","***** IPB002481 (Ferric uptake regulator family) with a combined E-value of 2.1e-25. IPB002481A 22-35 IPB002481B 46-89 IPB002481C 100-110","Residues 24-154 are 23% similar to a (PROTEOME REGULATION UPTAKE FERRIC) protein domain (PD079435) which is seen in O51592_BORBU.Residues 19-105 are 36% similar to a (UPTAKE REGULATION FERRIC PROTEOME) protein domain (PD079436) which is seen in Q9PIH7_CAMJE.Residues 16-148 are 27% similar to a (REGULATION UPTAKE FERRIC TRANSCRIPTION) protein domain (PD332498) which is seen in FUR_SYNY3.Residues 28-151 are 66% similar to a (UPTAKE FERRIC REGULATOR REGULATION) protein domain (PD098647) which is seen in P72567_STRPY.Residues 27-150 are 42% similar to a (UPTAKE FERRIC REGULATION REGULATOR) protein domain (PD002003) which is seen in Q9RQL3_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 08:52:01 2002","Wed Jan 16 09:14:56 2002","Wed Sep 27 12:58:33 2006","Thu Dec 6 16:09:31 2001","Thu Dec 6 16:09:31 2001","Thu Dec 6 16:09:31 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0540 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 19 08:52:01 2002","","No significant hits to the NCBI PDB database.","SMU.593","","Residues 24 to 143 (E-value = 3.3e-47) place SMu0540 in the FUR family which is described as Ferric uptake regulator family (PF01475)","Thu Dec 6 16:09:31 2001","24379071","","","Karkhoff-Schweizer,R.R., Schryvers,A.B. and Schweizer,H.P.Cloning and sequence analysis of the fur gene encoding aniron-regulatory protein of Neisseria meningitidisGene 141 (1), 139-140 (1994)PubMed: 8163167Thomas,C.E. and Sparling,P.F.Identification and cloning of a fur homologue from NeisseriameningitidisMol. Microbiol. 11 (4), 725-737 (1994)PubMed: 8196544","","Tue Mar 19 08:52:01 2002","1","","9","SMU.593","769" "SMu0541","552595","552750","156","ATGAAATTTATTATCATTGTTTTAATAGTGTTTTCTATTGTTAAAATCATTAGTATTATTTGGGTAAGTAAAATAATGAAGCCAAAGCCGATGACTCCAAAAGAAATTGAGGAGTATGATCGCAAGGAAGATCAAAAAGATGGTTTTGATTTTTAA","9.20","0.98","6084","MKFIIIVLIVFSIVKIISIIWVSKIMKPKPMTPKEIEEYDRKEDQKDGFDF","552747","","hypothetical protein","Membrane, Cytoplasm","No hits in gapped BLAST found.SMu0541 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-18]?$	signal-peptide
tmhmm	$\"[5-23]?$	transmembrane_regions

InterPro
IPR001295
Domain

Dihydroorotate dehydrogenase, core
PF01180	$\"[3-292]T$	DHO_dh
PS00912	$\"[244-264]T$	DHODEHASE_2

InterPro
IPR005720
Domain

Dihydroorotate dehydrogenase, class 1, core
TIGR01037	$\"[5-308]T$	pyrD_sub1_fam

InterPro
IPR012135
Family

Dihydroorotate dehydrogenase, classes 1 and 2
PIRSF000164	$\"[9-309]T$	DHO_oxidase

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[4-305]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR11938	$\"[14-311]T$	PTHR11938
PTHR11938:SF5	$\"[14-311]T$	PTHR11938:SF5
SSF51395	$\"[2-305]T$	SSF51395

","BeTs to 12 clades of COG0167COG name: Dihydroorotate dehydrogenaseFunctional Class: FThe phylogenetic pattern of COG0167 is amtkyqvCEbrhuj-------Number of proteins in this genome belonging to this COG is 2","***** IPB001295 (Dihydroorotate dehydrogenase) with a combined E-value of 2.4e-42. IPB001295A 10-21 IPB001295B 38-61 IPB001295C 68-77 IPB001295D 122-136 IPB001295E 161-171 IPB001295F 178-196 IPB001295G 216-229 IPB001295H 242-272","Residues 29-276 are 78% similar to a (DIHYDROOROTATE DEHYDROGENASE OXIDOREDUCTASE FLAVOPROTEIN) protein domain (PD001761) which is seen in PYRD_STRPN.Residues 6-108 are 54% similar to a (A DIHYDROOROTATE DEHYDROGENASE DHODEHASE) protein domain (PD407423) which is seen in Q9CFC9_LACLA.Residues 113-276 are 72% similar to a (DIHYDROOROTATE DEHYDROGENASE) protein domain (PD415821) which is seen in PYDA_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 15:15:46 2006","Thu Sep 7 15:15:46 2006","Thu Sep 7 15:15:46 2006","Mon Dec 10 08:06:19 2001","Mon Dec 10 08:06:19 2001","Mon Dec 10 08:06:19 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0542 is paralogously related (blast p-value < 1e-3) to SMu1118, a predicted dihydroorotate dehydrogenase B. ","Wed Jan 16 11:26:48 2002","Thu Sep 7 15:15:46 2006","pdb2DORA Chain A, Dihydroorotate Dehydrogenase A From Lactoco... 414 5e-117pdb1EP1A Chain A, Crystal Structure Of Lactococcus Lactis Dih... 106 5e-024pdb1D3GA Chain A, Human Dihydroorotate Dehydrogenase Complexe... 66 6e-012","SMU.595c","","Residues 3 to 292 (E-value = 4.8e-102) place SMu0542 in the DHO_dh family which is described as Dihydroorotate dehydrogenase (PF01180)","Mon Dec 10 08:06:19 2001","","","","Andersen,P.S., Jansen,P.J. and Hammer,K.Two different dihydroorotate dehydrogenases in Lactococcus lactisJ. Bacteriol. 176 (13), 3975-3982 (1994)PubMed: 8021180Bjornberg,O., Rowland,P., Larsen,S. and Jensen,K.F.Active site of dihydroorotate dehydrogenase A from Lactococcuslactis investigated by chemical modification and mutagenesisBiochemistry 36 (51), 16197-16205 (1997)PubMed: 9405053Rowland,P., Nielsen,F.S., Jensen,K.F. and Larsen,S.The crystal structure of the flavin containing enzymedihydroorotate dehydrogenase A from Lactococcus lactisStructure 5 (2), 239-252 (1997)PubMed: 9032071Gao,G., Nara,T., Nakajima-Shimada,J. and Aoki,T.Novel organization and sequences of five genes encoding all sixenzymes for de novo pyrimidine biosynthesis in Trypanosoma cruziJ. Mol. Biol. 285 (1), 149-161 (1999)PubMed: 9878395","","Mon Dec 10 09:13:55 2001","1","","9","SMU.595c","286" "SMu0543","553966","554658","693","ATGGTAAAATTAGTATTTGCTCGTCATGGTGAATCAGAATGGAACAAGGCTAACCTTTTTACTGGCTGGGCTGATGTTGACCTTTCAGAAGAAGGAACGCAACAAGCAATTGATGCCGGCAAACTCATTAAAGAAGCAGACATCAAATTTGACCTTGCTTTCACATCAGTTTTGACACGTGCAATCAAGACAACTAATTTGGCGCTTGAATATTCTGATCAACTTTGGGTACCAGTTGAAAAGTCATGGCGTTTGAATGAACGTCACTATGGTGGCTTGACTGGTAAAAATAAAGCTGAAGCTGCGGAAAAATTTGGAGACGAACAAGTTCACATTTGGCGTCGCTCATATGATGTATTGCCGCCAGCTATGGCCAAAGACGATCCATACTCAGCACACACTGACCGTCGTTATGCAAATCTTGATGATACTGTTATTCCAGATGCAGAAAACTTAAAAGTCACCTTAGAACGTGCTCTTCCATACTGGGAAGATAAAATTGCTCCAGCTCTTAAAGATGGAAAAAATGTATTTGTTGGAGCACATGGTAACTCTATCCGTGCTCTTGTAAAACATATCAAACAATTGTCAGATGATGACATTATGGGTGTTGAAATTCCAAACTTCCCACCATTAGTTTTTGAATTTGACGAAAATTTAAATGTCACTGCTGAATACTATCTTGGTAAATAA","5.00","-8.54","26035","MVKLVFARHGESEWNKANLFTGWADVDLSEEGTQQAIDAGKLIKEADIKFDLAFTSVLTRAIKTTNLALEYSDQLWVPVEKSWRLNERHYGGLTGKNKAEAAEKFGDEQVHIWRRSYDVLPPAMAKDDPYSAHTDRRYANLDDTVIPDAENLKVTLERALPYWEDKIAPALKDGKNVFVGAHGNSIRALVKHIKQLSDDDIMGVEIPNFPPLVFEFDENLNVTAEYYLGK","554655","For other 'gpm' genes see SMu0067 (gpm); SMu0640 (gpmB); SMu1008 (gpm); SMu1009 (gpm) and SMu1010 (gpm). ","phosphoglycerate mutase","Cytoplasm","Several matches in gapped BLAST to phosphoglyceromutase: residues 1-230 are 90% similar to the enzyme in S.pneumoniae (gi5578891). Residues 1-239 are 88% similar to the protein from S.pyogenes (gi15675343).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0764 (1e-122).","

InterPro
IPR005952
Family

Phosphoglycerate mutase 1
PTHR11931	$\"[1-229]T$	Phosphogly_mut1
TIGR01258	$\"[2-230]T$	pgm_1

InterPro
IPR013078
Domain

Phosphoglycerate mutase
PF00300	$\"[3-189]T$	PGAM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1240	$\"[2-228]T$	G3DSA:3.40.50.1240
PIRSF001490	$\"[2-230]T$	DPGAM
SSF53254	$\"[1-229]T$	SSF53254

","BeTs to 6 clades of COG0588COG name: Phosphoglycerate mutase 1Functional Class: GThe phylogenetic pattern of COG0588 is ----Y---e-rh----olin-Number of proteins in this genome belonging to this COG is 2","***** IPB001345 (Phosphoglycerate mutase family) with a combined E-value of 8.7e-44. IPB001345A 4-33 IPB001345B 53-65 IPB001345C 77-108 IPB001345D 147-165","Residues 93-225 are 88% similar to a (PGAM MUTASE PHOSPHOGLYCERATE ISOMERASE) protein domain (PD003480) which is seen in Q9X9S2_STRPN.Residues 92-143 are 59% similar to a (MUTASE PGAM ISOMERASE BPG-DEPENDENT) protein domain (PD245151) which is seen in Q9D6W0_MOUSE.Residues 147-217 are 39% similar to a (CG7059) protein domain (PD302946) which is seen in Q9VD18_DROME.Residues 8-91 are 92% similar to a (MUTASE PROTEOME COMPLETE PHOSPHOGLYCERATE PGAM) protein domain (PD000730) which is seen in Q9X9S2_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 13:57:23 2006","Fri Sep 8 13:57:23 2006","Fri Sep 8 13:55:53 2006","Mon Dec 10 09:15:22 2001","Mon Dec 10 09:15:22 2001","Mon Dec 10 09:15:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0543 is paralogously related (blast p-value < 1e-3) to SMu0067,a predicted phosphoglycerate mutase-like protein, SMu1008,SMu0640,and SMu1010 all predicted phosphoglycerate mutases. ","Wed Jan 16 13:26:43 2002","Fri Sep 8 13:55:53 2006","pdb1QHFA Chain A, Yeast Phosphoglycerate Mutase-3pg Complex S... 258 4e-070pdb4PGMB Chain B, Saccharomyces Cerevisiae Phosphoglycerate M... 258 4e-070pdb3PGM Phosphoglycerate Mutase (E.C.2.7.5.3) De-Phospho E... 243 1e-065","SMU.596","","Residues 2 to 225 (E-value = 7.5e-114) place SMu0543 in the PGAM family which is described as Phosphoglycerate mutase family (PF00300)","Mon Dec 10 09:15:22 2001","24379074","","","Yomano,L.P., Scopes,R.K. and Ingram,L.O.Cloning, sequencing, and expression of the Zymomonas mobilisphosphoglycerate mutase gene (pgm) in Escherichia coliJ. Bacteriol. 175 (13), 3926-3933 (1993)PubMed: 8320209","","Mon Dec 10 09:22:46 2001","1","","9","SMU.596","319" "SMu0544","554905","556983","2079","ATGGTATCCCAAAAAAATAAATCTAAAAAGGGTCAATCTAAAACGTTTACCTTAATTTCAAATAGAATTAATCTCCTATTTTTTTTGATTGTCGCTTTGTTTACTGTTTTGCTTTTGAGGTTAGCTCAGATGCAGCTTTATGATGCAAAGTTTTACAAATCTAAATTGACAGAGTCAACAACATATACTATAAAAACCTCCAGCCCTCGCGGACAAATTTATGACGCTAAAGGGGTGGCTTTAGTTGAAAACGAGGTTAAAGAGGTTGTTGCCTTTACAAGAAGCAATACCATGACTGCCAAGGATATTAAAGCAAATGCAAAAAAGTTAGCAGATATGGTGACTTTAACTGAATCTAAGGTAACCAAACGTCAGAAAAAAGATTACTATCTGGCAGATCCAAAAAATTATCAAAAAATCGTTAAAAAATTACCAAATAATAAAAAATATGATAACTTTGGAAATAACCTAACGGAATCGAAGATCTATGCAAATGCTGTTAAAGCAGTTCCAAACAGTGCTATTGATTATTCTGAAGATGAGAAAAAAATCATTCATATTTTCAGCCAGATGAATGCAACCTCTGTTTTTAATACAGCTTCGTTAACAACAGGAGATTTAACAGCTGAGCAAATTGCAGTATTGGCTACAAGCAAATCAGATTTAAAGGGAATTTCTGTTAAGACTGACTGGGAACGTAAAACAGATAAAAATTCCATTACTTCTATTATCGGTAAAGTTTCCAGTCAAAAAACCGGTCTGCCTGCTGAAGAAGCCAATAACTATGTTAAAAAAGGTTATTCTCTGAATGACCGCGTTGGAACATCTTATCTTGAAAAGCAATATGAAAACGATTTGCAAGGTAGTCGTACTGTTCAAGCAATCAAGGTTAACAAAGAAGGTAAAATTATCAGTGATAAGACCACTGCCAAAGGGACTAAAGGAAAAAATCTGAAGTTGACCCTTGATCTTGAATTTCAAAAAGGTGTTGAACAAATTCTTAACCAATATTTTAATTCTGAATTAGCATCTGGAAATACCAAGTATTCTGAAGGCGTTTATGCTGTTGTTCTTAACCCGAACACAGGTGCAGTTCTTTCTATGGCTGGTTTGGAACACGACCTTAAAACGGGCGAAGTATCTTCTAATGCTCTTGGAGCGGTTACTGAAGTCTTTACTCCGGGTTCCGTTGTTAAAGGAGCGACTTTGACAGCTGGTTGGGAAAACGGTGTCTTATCAGGCAATCAAGTACTCAATGACCAGCCTATTCAATTTGCGGGTTCAAGCCCTATTAACTCTTGGTTTACCAATGGATCAACTCCTCTTACAGCAAGTCAATCCTTAGAGTATTCTTCTAATACTTATATGGTTCAATTGGCTTTAAAATTAATGGGACAAGATTATCATAGTGGTATGACCTTATCAACAGATGGCTATAAGGAAGCTATGGAGAAATTAAGAGCTACTTATGCTCAATATGGTTTGGGTGTCTCAACAGGAATTGACCTTCCGGGAGAGTCAAAGGGCTATACGCCAGAACATTATGATCCTTCTAATGTTTTAACAGAATCATTTGGGCAGTTTGATAACTATACGGCTATGCAGCTGGCACAATATGCTGCAGCTGTCGCAAATGGTGGTAAACGTATTGCTCCCCATTTGGTTGAAGGTATCTATGATAATAATAAAACAGGCGGTTTAGGAAATCTTGTTCAATCTATTGACACCAAGGTTTTAAATAATGTTTCTATCTCTAGCGATGACATGGGGATTATCAAGGAAGGTTTCTATAATGTTGTTAACGGTGGTAGTTATGCAACAGGGAAGACTCTTGCAAAAGGGGCAAGTGTTCCCATTTCGGCAAAAACAGGGACAGCCGAAGCTTACGTGACAGGAGATGATGGTAAATCTGTTTATACATCCAATTTAAACGTTGTTGCTTATGCACCAAGCAGCAATCCTCAAATTGCTGTAGCTGTTGTCTTGCCACATGAGACAGACCTTCATGGAACCACTAGTCATGCTATTACGAGAGATATCATCAATCTTTATCAAAAGATGTATCCAATGAATCAGTGA","9.80","11.97","75152","MVSQKNKSKKGQSKTFTLISNRINLLFFLIVALFTVLLLRLAQMQLYDAKFYKSKLTESTTYTIKTSSPRGQIYDAKGVALVENEVKEVVAFTRSNTMTAKDIKANAKKLADMVTLTESKVTKRQKKDYYLADPKNYQKIVKKLPNNKKYDNFGNNLTESKIYANAVKAVPNSAIDYSEDEKKIIHIFSQMNATSVFNTASLTTGDLTAEQIAVLATSKSDLKGISVKTDWERKTDKNSITSIIGKVSSQKTGLPAEEANNYVKKGYSLNDRVGTSYLEKQYENDLQGSRTVQAIKVNKEGKIISDKTTAKGTKGKNLKLTLDLEFQKGVEQILNQYFNSELASGNTKYSEGVYAVVLNPNTGAVLSMAGLEHDLKTGEVSSNALGAVTEVFTPGSVVKGATLTAGWENGVLSGNQVLNDQPIQFAGSSPINSWFTNGSTPLTASQSLEYSSNTYMVQLALKLMGQDYHSGMTLSTDGYKEAMEKLRATYAQYGLGVSTGIDLPGESKGYTPEHYDPSNVLTESFGQFDNYTAMQLAQYAAAVANGGKRIAPHLVEGIYDNNKTGGLGNLVQSIDTKVLNNVSISSDDMGIIKEGFYNVVNGGSYATGKTLAKGASVPISAKTGTAEAYVTGDDGKSVYTSNLNVVAYAPSSNPQIAVAVVLPHETDLHGTTSHAITRDIINLYQKMYPMNQ","556980","For other 'pbp' genes see SMu0811 (pbpX); SMu1808 (pbp1b); SMu0412 (pbp2X); SMu0424 (pbp1a) and SMu1771 (pbp2a).","penicillin-binding protein 2b","Extracellular, Membrane","Several matches in gapped BLAST to penicillin-binding protein 2b: residues 19-688 are 52% similar to the protein in S.thermophilus (gi|1685112|). Residues 22-691 are 54% similar to the protein from S.pneumoniae (gi|15903560|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0765 (0.0).","

InterPro
IPR001460
Domain

Penicillin-binding protein, transpeptidase
PF00905	$\"[353-682]T$	Transpeptidase

InterPro
IPR005311
Domain

Penicillin-binding protein, dimerisation domain
PF03717	$\"[65-308]T$	PBP_dimer
SSF56519	$\"[58-321]T$	PBP_dimer

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[321-689]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[324-689]T$	G3DSA:3.40.710.10
G3DSA:3.90.1310.10	$\"[198-320]T$	G3DSA:3.90.1310.10

","BeTs to 11 clades of COG0768COG name: Cell division protein FtsI/penicillin-binding protein 2Functional Class: MThe phylogenetic pattern of COG0768 is -----QVcEBRHUJ--OLINXNumber of proteins in this genome belonging to this COG is 2","***** IPB001460 (Penicillin binding protein transpeptidase domain) with a combined E-value of 6.2e-10. IPB001460A 70-78 IPB001460B 320-328 IPB001460C 532-547","Residues 385-465 are 68% similar to a (PENICILLIN-BINDING PROTEOME COMPLETE CELL PEPTIDOGLYCAN) protein domain (PD000435) which is seen in P96052_STRTR.Residues 622-691 are 61% similar to a (PENICILLIN-BINDING PROTEOME COMPLETE CELL 2B) protein domain (PD011751) which is seen in Q54624_STRPN.Residues 212-303 are 57% similar to a (2B PENICILLIN BINDING PENICILLIN-BINDING) protein domain (PD003377) which is seen in P96052_STRTR.Residues 129-211 are 57% similar to a (2B PENICILLIN-BINDING SYNTHESIS ALL) protein domain (PD041960) which is seen in P96052_STRTR.Residues 558-620 are 50% similar to a (2B PENICILLIN BINDING PENICILLIN-BINDING) protein domain (PD137190) which is seen in Q54616_STRPN.Residues 503-557 are 47% similar to a (PENICILLIN-BINDING COMPLETE PROTEOME CELL MEMBRANE) protein domain (PD191093) which is seen in Q54627_STRPN.Residues 326-381 are 69% similar to a (2B BINDING PENICILLIN PENICILLIN-BINDING) protein domain (PD413907) which is seen in Q54630_STRPN.Residues 326-368 are 69% similar to a (PENICILLIN-BINDING COMPLETE PROTEOME CELL PEPTIDOGLYCAN) protein domain (PD041955) which is seen in Q57504_STRPN.Residues 503-557 are 54% similar to a (2B PENICILLIN BINDING PENICILLIN-BINDING) protein domain (PD186181) which is seen in P96052_STRTR.Residues 425-627 are 27% similar to a (PROTEOME COMPLETE) protein domain (PD162287) which is seen in Q9PLP5_CHLMU.Residues 19-128 are 49% similar to a (PENICILLIN-BINDING 2B PROTEOME COMPLETE) protein domain (PD396710) which is seen in P96052_STRTR.Residues 20-128 are 35% similar to a (PENICILLIN-BINDING 2X CELL PROTEOME) protein domain (PD245972) which is seen in Q9XDB3_STAAU.Residues 370-502 are 36% similar to a (PROTEOME COMPLETE YKUA) protein domain (PD396925) which is seen in O31399_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 16:36:05 2002","Mon Dec 10 09:23:57 2001","Thu Oct 10 16:36:05 2002","Mon Dec 10 09:23:57 2001","Mon Dec 10 09:23:57 2001","Mon Dec 10 09:23:57 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0544 is paralogously related (blast p-value < 1e-3) to SMu0412, a predicted penicillin-binding protein 2X, SMu0429,a predicted conserved hypothetical protein, and SMu1771 a predicted penicillin-binding protein 2a.","Wed Jan 16 13:32:13 2002","","No significant hits to the NCBI PDB database.","SMU.597","","Residues 65 to 308 (E-value = 8.5e-28) place SMu0544 in the PBP_dimer family which is described as Penicillin-binding Protein dimerisation domain (PF03717)Residues 353 to 682 (E-value = 3.6e-98) place SMu0544 in the Transpeptidase family which is described as Penicillin binding protein transpeptidase domain (PF00905)","Mon Dec 10 09:23:57 2001","24379075","","","Stingele,F. and Mollet,B.Disruption of the gene encoding penicillin-binding protein 2b(pbp2b) causes altered cell morphology and cease inexopolysaccharide production in Streptococcus thermophilus Sfi6Mol. Microbiol. 22 (2), 357-366 (1996)PubMed: 8930919","","Mon Dec 10 09:42:10 2001","1","","9","SMU.597","82" "SMu0545","556993","557592","600","ATGCTCTACCCAACGCCTATTGCCAAACTTATTGAGAGCTTCACAAAATTACCGGGTATTGGTATCAAAACAGCGACTCGCTTAGCTTTTTATACGATTGGTATGAGTGATGAAGACGTTAATAACTTTGCTAAAAATCTTCTAGCTGCTAAACGAGAATTGACCTACTGTTCTGTTTGTGGCAATCTGACAGATGATGATCCTTGCAATATTTGTACAGATGAAAGCAGAGACCGCTCGACTGTTTTAGTAGTTGAAGATAGTAAGGATGTTTCTGCAATGGAAAAAATTCAGGAATATCATGGTCTTTATCATGTTTTACACGGCCTGATTTCTCCTATGAATGGTATTGGTCCTGATGATATTAATTTGAAAAGTCTTCTGACACGCCTACGTGATAATAGTGATATTCATGAAGTCATTATCGCAACTAATGCCACAGCAGATGGAGAAGCAACGGCTATGTATATTTCCAGAGTTCTCAAACCTGCTGGTATTACAGTTACACGTTTAGCGCGTGGGCTTGCTGTTGGTTCTGACATTGAGTATGCTGATGAAGTAACTCTGCTTCGAGCAATTGAAAACAGGACAGAGTTATAA","4.80","-8.22","21804","MLYPTPIAKLIESFTKLPGIGIKTATRLAFYTIGMSDEDVNNFAKNLLAAKRELTYCSVCGNLTDDDPCNICTDESRDRSTVLVVEDSKDVSAMEKIQEYHGLYHVLHGLISPMNGIGPDDINLKSLLTRLRDNSDIHEVIIATNATADGEATAMYISRVLKPAGITVTRLARGLAVGSDIEYADEVTLLRAIENRTEL","557589","For other 'rec' genes see SMu0021 (recO);SMu0532 (recN); SMu1956 (recF); SMu1892 (recA); SMu0425 (recU) ; SMu1669 (recG); SMu1705 (recD) and SMu1339 (recJ).From Genbank [gi:3024524].This protein may play a role in DNA repair.It seems to be involved in an REDBC-independent recombinational process of DNA repair.It may act with RECF and RECO.","recombination protein","Cytoplasm","Several matches in gapped BLAST to recombination proteins: residues 1-199 are 87% similar to the enzyme in S.pyogenes (gi15675339) and are 84% similar to the protein from S.pneumoniae (gi6634573).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0766 (2e-98).","

InterPro
IPR000093
Family

RecR protein
PF02132	$\"[38-79]T$	RecR
TIGR00615	$\"[1-197]T$	recR
PS01300	$\"[57-78]T$	RECR

InterPro
IPR003583
Domain

Helix-hairpin-helix DNA-binding, class 1
SM00278	$\"[12-31]T$	HhH1

InterPro
IPR006154
Domain

Toprim subdomain
SM00493	$\"[80-166]T$	TOPRIM

InterPro
IPR006171
Domain

TOPRIM
PF01751	$\"[80-174]T$	Toprim

noIPR
unintegrated

unintegrated
SSF111304	$\"[1-199]T$	SSF111304

","BeTs to 9 clades of COG0353COG name: Recombinational DNA repair proteinFunctional Class: LThe phylogenetic pattern of COG0353 is -----q-cebrhuj---linxNumber of proteins in this genome belonging to this COG is 1","***** IPB000093 (RecR putative zinc finger) with a combined E-value of 1.6e-98. IPB000093A 18-68 IPB000093B 77-117 IPB000093C 128-157 IPB000093D 166-196","Residues 35-199 are 89% similar to a (RECOMBINATION DNA REPAIR ZINC-FINGER) protein domain (PD006826) which is seen in RECR_STRTR.Residues 1-34 are 91% similar to a (RECOMBINATION DNA REPAIR ZINC-FINGER) protein domain (PD099651) which is seen in Q9RCP8_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 15:46:50 2006","Tue Aug 29 15:46:50 2006","Tue Aug 29 15:46:50 2006","Mon Dec 10 09:37:13 2001","Mon Dec 10 09:37:13 2001","Mon Dec 10 09:37:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0545 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 10 09:39:30 2001","","No significant hits to the NCBI PDB database.","SMU.598","","Residues 38 to 79 (E-value = 1.6e-22) place SMu0545 in the RecR family which is described as RecR protein (PF02132)Residues 80 to 174 (E-value = 1.2e-16) place SMu0545 in the Toprim family which is described as Toprim domain (PF01751)","Tue Aug 29 15:46:50 2006","24379076","","","Alonso,J.C., Shirahige,K. and Ogasawara,N.Molecular cloning, genetic characterization and DNA sequenceanalysis of the recM region of Bacillus subtilisNucleic Acids Res. 18 (23), 6771-6777 (1990)PubMed: 2124672","","Thu Oct 24 12:33:11 2002","1","","9","SMU.598","544" "SMu0546","557804","558853","1050","ATGTCTAAAGAAACGCTTGTTTTATTATATGGTGGCCGTTCTGCAGAACGCGATGTTTCTGTGCTCTCAGCTGAGAGTGTCATGCGAGCCATAAATTATGACAACTTTTTAGTCAAAACTTATTTCATTACGCAAGCGGGTGACTTTATTAAGACGCAAGAATTTGATAGTCAACCATCAGAAACTGATAAACTGATGACAAATGACACGATTATTGCTTCTCAAAAAATTAAGCCAAGTGATATTTATGAGGAAGAAGCAGTTGTTTTTCCTGTTCTTCATGGGCCTATGGGAGAGGATGGTTCTATTCAGGGCTTTCTTGAAGTTTTAAAAATGCCTTATGTGGGAACCAATATTCTGTCATCTAGTGTAGCTATGGATAAGATTACAACAAACCAAGTTTTAGAAAGTGCGACTACTATTCCTCAAGTAGCTTATGTTGCTCTTATTGAAGGCGAGCCTTTAGAAAGCAAGTTGGCAGAAGTTGAAGAGAAATTGATTTATCCTGTATTTGTTAAGCCAGCTAATATGGGTTCTAGTGTTGGTATTTCTAAAGCAGAAAATCGCACTGACTTAAAACAAGCTATTGCACTTGCTTTGAAGTATGACAGTCGTGTTTTAATTGAACAAGGTGTGGATGCGCGTGAGATTGAGGTTGGTATTTTAGGAAATACTGATGTTAAAACAACTTTACCGGGAGAGATTGTCAAAGATGTGGCTTTTTATGATTACGAAGCCAAGTATATTGATAATAAGATCACCATGGCTATTCCGGCAGAAATAGATCCTGTTATCGTTGAAAAAATGCGGGATTATGCTGCAACAGCTTTCCGAACTTTGGGCTGCTGTGGACTTTCTCGCTGTGATTTCTTCCTAACAGAGGATGGGAAAGTTTATTTGAATGAACTCAACACTATGCCCGGCTTTACTCAGTGGTCTATGTATCCTCTTCTTTGGGAAAATATGGGGCTGTCTTATTCAGTTTTGATTGAAGAATTAGTTAGTCTTGCTAAAGAAATGTTTGATAAACGCGAAAGCCATTTGGTTTAA","4.40","-20.62","38825","MSKETLVLLYGGRSAERDVSVLSAESVMRAINYDNFLVKTYFITQAGDFIKTQEFDSQPSETDKLMTNDTIIASQKIKPSDIYEEEAVVFPVLHGPMGEDGSIQGFLEVLKMPYVGTNILSSSVAMDKITTNQVLESATTIPQVAYVALIEGEPLESKLAEVEEKLIYPVFVKPANMGSSVGISKAENRTDLKQAIALALKYDSRVLIEQGVDAREIEVGILGNTDVKTTLPGEIVKDVAFYDYEAKYIDNKITMAIPAEIDPVIVEKMRDYAATAFRTLGCCGLSRCDFFLTEDGKVYLNELNTMPGFTQWSMYPLLWENMGLSYSVLIEELVSLAKEMFDKRESHLV","558850","From Genbank:[gi:2494028]This protein is involved in cell wall formation.","D-alanine-D-alanine ligase","Cytoplasm","Matches in gapped BLAST to D-alanine-D-alanine ligase:residues 106-303 are 98% similar to the previously published enzyme in S.mutans (gi1814248). Residues 1-349 are 75% similar to the enzyme in S.pyogenes (gi15675338). Residues 3-349 are 73% similar to the protein from S.pneumoniae (gi6634574).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0767 (1e-151).","

InterPro
IPR000291
Family

D-alanine--D-alanine ligase/VANA/B/C
PS00843	$\"[94-105]T$	DALA_DALA_LIGASE_1
PS00844	$\"[280-308]T$	DALA_DALA_LIGASE_2

InterPro
IPR005905
Family

D-alanine--D-alanine ligase
TIGR01205	$\"[5-338]T$	D_ala_D_alaTIGR

InterPro
IPR011095
Domain

D-alanine--D-alanine ligase, C-terminal
PF07478	$\"[127-335]T$	Dala_Dala_lig_C

InterPro
IPR011127
Domain

D-alanine--D-alanine ligase, N-terminal
PF01820	$\"[4-126]T$	Dala_Dala_lig_N

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[133-335]T$	ATP_GRASP

InterPro
IPR013816
Domain

ATP-grasp fold, subdomain 2
G3DSA:3.30.470.20	$\"[188-340]T$	ATP_grasp_subdomain_2

InterPro
IPR013817
Domain

Pre-ATP-grasp fold
G3DSA:3.40.50.20	$\"[1-116]T$	Pre-ATP_grasp

noIPR
unintegrated

unintegrated
PTHR23132	$\"[76-340]T$	PTHR23132
SSF52440	$\"[3-126]T$	SSF52440
SSF56059	$\"[128-338]T$	SSF56059

","BeTs to 11 clades of COG1181COG name: D-alanine-D-alanine ligase and related ATP-grasp enzymesFunctional Class: MThe phylogenetic pattern of COG1181 is -----qvcEbrhuj--olinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000291 (D-alanine--D-alanine ligase) with a combined E-value of 6.3e-105. IPB000291A 8-31 IPB000291B 87-124 IPB000291C 168-205 IPB000291D 241-250 IPB000291E 257-292 IPB000291F 300-310","Residues 7-334 are 65% similar to a (LIGASE SYNTHETASE CARBOXYLASE COMPLETE) protein domain (PD000180) which is seen in DDL_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 13:48:39 2002","Wed Jan 16 13:44:28 2002","Fri Sep 8 14:05:22 2006","Mon Dec 10 09:58:13 2001","Mon Dec 10 09:58:13 2001","Mon Dec 10 09:58:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0546 is paralogously related (blast p-value < 1e-3) to SMu0784, a predicted carbamoyl-phosphate synthase, large subunit.","Wed Jan 16 13:44:28 2002","Fri Sep 8 14:05:22 2006","pdb1EHIA Chain A, D-Alanine:d-Lactate Ligase (Lmddl2) Of Vanc... 187 2e-048pdb1IOV Complex Of D-Ala:d-Ala Ligase With Adp And A Phosph... 164 1e-041pdb1IOW Complex Of Y216f D-Ala:d-Ala Ligase With Adp And A... 163 3e-041","SMU.599","","Residues 4 to 335 (E-value = 8.4e-144) place SMu0546 in the Dala_Dala_ligas family which is described as D-ala D-ala ligase (PF01820)","Mon Dec 10 09:58:13 2001","24379077","","","Enright,M.C. and Spratt,B.G.Extensive variation in the ddl gene of penicillin-resistantStreptococcus pneumoniae results from a hitchhiking effect drivenby the penicillin-binding protein 2b geneMol. Biol. Evol. 16 (12), 1687-1695 (1999)PubMed: 10605111Massidda,O., Anderluzzi,D., Friedli,L. and Feger,G.Unconventional organization of the division and cell wall genecluster of Streptococcus pneumoniaeMicrobiology 144 (Pt 11), 3069-3078 (1998)PubMed: 9846742Evers,S., Casadewall,B., Charles,M., Dutka-Malen,S., Galimand,M.and Courvalin,P.Evolution of structure and substrate specificity inD-alanine:D-alanine ligases and related enzymesJ. Mol. Evol. 42 (6), 706-712 (1996)PubMed: 8662022Gholizadeh,Y., Prevost,M., Van Bambeke,F., Casadewall,B.,Tulkens,P.M. and Courvalin,P.Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of EnterococcusfaeciumProtein Sci. 10 (4), 836-844 (2001)PubMed: 11274474","Fri Sep 8 14:05:22 2006","Mon Dec 10 10:06:47 2001","1","","9","SMU.599","320" "SMu0547","559585","559025","561","ATGAATACTATGTTTAAATCACCTAAGCTTAGTCCGCAGCGCTTGGTCACTCTGGCCATGTTGATTGCCTTAGCTTTTGCTATTGGAAAACTTTCCATCCCCATTATTCCCCAACAACTGATTATCAGCCCAACTTTCATTGTTAATGTGATGATTGGTATGATTGGTGGACCAATCTGGGCCTTCATCAGTTTGGCTATTTTGGATATAGTGGACAACCTATCCAGTGGTGCAGGTAACTTTATTATCTGGTGGACACTGCTAGAAGCCGTTCAAGGATTATTTTATGGACTTTTCTTTTATCAAAAATCGCTGAGCTGGACAAATAAAAAAGACTGGCTACACGTTACTATTGCTACAGCAATCATTATGCTTATCGGAAGCTTTATCTTCACTCCTTTGCTCGTCCAGATTTACTATGGTGTCCCATTTTGGGCACAATTTGCAGCAGGGCGTTGGTTAAAAATCTTTGAAATCCCTATTCGGATCCTAGTCACTATGGCAATTATGCCTCAGTTGCAGCGGATTCCAGAATTACGAAAACTTGCAAATTTTAAATAG","10.90","8.22","21030","MNTMFKSPKLSPQRLVTLAMLIALAFAIGKLSIPIIPQQLIISPTFIVNVMIGMIGGPIWAFISLAILDIVDNLSSGAGNFIIWWTLLEAVQGLFYGLFFYQKSLSWTNKKDWLHVTIATAIIMLIGSFIFTPLLVQIYYGVPFWAQFAAGRWLKIFEIPIRILVTMAIMPQLQRIPELRKLANFK","559028","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins:residues 6-186 are 41% similar to S.suis (gi13345176).Residues 13-139 are 32% similar to Mycoplasma pneumoniae (gi13508187). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0835 (0.001).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-27]?$	signal-peptide
tmhmm	$\"[15-34]?$ $\"[40-60]?$ $\"[81-101]?$ $\"[115-135]?$	transmembrane_regions

InterPro
IPR001202
Domain

WW/Rsp5/WWP
PS01159	$\"[14-38]?$	WW_DOMAIN_1

InterPro
IPR002657
Family

Bile acid:sodium symporter
PTHR10361	$\"[14-306]T$	BilAc/Na_symport
PF01758	$\"[41-221]T$	SBF

","BeTs to 3 clades of COG0385COG name: Predicted Na+-dependent transporterFunctional Class: RThe phylogenetic pattern of COG0385 is ----yq-ceB-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 183-304 are 50% similar to a (TRANSPORTER PROTEOME COMPLETE) protein domain (PD002890) which is seen in O34524_BACSU.Residues 45-131 are 56% similar to a (PROTEOME COMPLETE TRANSMEMBRANE) protein domain (PD040988) which is seen in Q9HYX6_PSEAE.Residues 40-131 are 32% similar to a (ACID ILEAL COTRANSPORTER BILE) protein domain (PD339996) which is seen in Q9CXB2_MOUSE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 08:56:30 2002","Wed Jan 16 13:53:32 2002","Wed Sep 27 12:45:20 2006","Mon Dec 10 10:13:05 2001","","Mon Dec 10 10:13:05 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0548 is paralogously related (blast p-value < 1e-3) to SMu1869, a predicted membrane protein.","Wed Jan 16 13:53:32 2002","","No significant hits to the NCBI PDB database.","SMU.602","","Residues 41 to 221 (E-value = 2.5e-42) place SMu0548 in the SBF family which is described as Sodium Bile acid symporter family (PF01758)","Mon Dec 10 10:13:05 2001","24379079","","","","","","1","","9","SMU.602","" "SMu0549","560966","562324","1359","ATGAAGTTAACTTTACAAGAGATAGCCTCGGTTGTAGGTGCTCAAAATGATGTCAGTCTTTTTGAAGATCTTACCATCAATGCTATTGAATTTGACAGCCGCCAGATAAAGACAGGTGATTTATTTTTACCTCTACAGGGTGCGCGTGATGGCCATGAGTTTATTGATACTGCTTTTGCCAATGGTGCTGTTGCTACTTTTTCCGAAAAAAACATAACCAGTGATTATCCCTATATTTTAGTTGTAGATTGCTTGAAAGCTTTTCAGGATTTGGCGCAATACTATTTGGAGAAAATGCGGGTTGATGTTATTGCTGTAACAGGATCTAACGGAAAAACAACCACAAAGGACATGATAGCAACTATTTTAGCAACTACTTACAAAACTTACAAGACACAAGGTAATTATAATAATGAAATTGGTCTGCCTTATACAGTTTTACACATGCCTGATGATACTGAAAAAATTGTACTTGAAATGGGTCAGGACCATCTCGGTGATATTGCCCTTCTGTCTAATCTTACCCATCCTCACATAGCTGTTGTCACCTTGATTGGTGAAGCTCATTTAGAGTTCTTTGGCAGCCGTGAGAAAATTGCTGAAGGAAAAATGCAAATTACTCAAGGAATGGATGGTCATGGGATTCTTATTGCACCAGCGGATAAAATCATTAATTCATTTTTACCAGAAAAGCAAAAGGTTATTCGCTTTGGAGCTGATGAAGATATTTTTGTGACCGAATTAGAAGAGCATAAAAACTATTTGAACTTTAAAACGAATTTCCTAGATAATGAGATTAAATTGCCAGTAACTGGTAAATATAATGCTACCAATGCTATGATTGCTAGCTATGTTGGAAAACTGCTTAATGTCTCTGAAGAAAAGATTATCTCTGCACTGGCTCAGCTCAATCTAACTCGTAATCGAACGGAATGGAAAAAAGCGGCTAACGGTGCAGATATCTTATCTGATGTTTATAATGCTAATCCAACAGCTATGAAACTGATTTTGGAGACTTTCTCCAGCATTCCAGCAAATAATGGTGGTAAAAAAATTGCGGTGCTGGCAGATATGAAAGAATTAGGAGACAGTGAATTAGCCTTACATGCAGCCATGATTGCTAGTCTAGATCCTGCAGTGATAGATCGTATTTTTCTTTTTGGACCACTAATGCAAGCTCTAGCAGATGAAGTCGCCCAAGTTTATTCAGTAGGGAAATGGTATTATTTTGCCCAAGCTGATCAGGTAGATGAGCTCACTGAGCAAATTCAAAAGGTATTAGGCCCTAATGACCAAATACTTCTAAAGGGATCAAATTCCATGAAATTGGCCCAAGTTGTGGAGTGTTTGGAAGGGTAA","4.70","-18.89","49813","MKLTLQEIASVVGAQNDVSLFEDLTINAIEFDSRQIKTGDLFLPLQGARDGHEFIDTAFANGAVATFSEKNITSDYPYILVVDCLKAFQDLAQYYLEKMRVDVIAVTGSNGKTTTKDMIATILATTYKTYKTQGNYNNEIGLPYTVLHMPDDTEKIVLEMGQDHLGDIALLSNLTHPHIAVVTLIGEAHLEFFGSREKIAEGKMQITQGMDGHGILIAPADKIINSFLPEKQKVIRFGADEDIFVTELEEHKNYLNFKTNFLDNEIKLPVTGKYNATNAMIASYVGKLLNVSEEKIISALAQLNLTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSSIPANNGGKKIAVLADMKELGDSELALHAAMIASLDPAVIDRIFLFGPLMQALADEVAQVYSVGKWYYFAQADQVDELTEQIQKVLGPNDQILLKGSNSMKLAQVVECLEG","562321","For other 'mur' genes see SMu0653 (murN); SMu0654 (murM);SMu0883 (murB); SMu1529 (murE); SMu1566 (murI); SMu0498 (murD);SMu0499 (murG); SMu1577 (murC); SMu1304 (murC);SMu1386 (murA) and SMu1429 (murZ).","D-Ala-D-Ala adding enzyme; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase (UDP-N-acetylmuramyl pentapeptide synthase)","Cytoplasm","Several matches in gapped BLAST to putative D-Ala-D-Ala adding enzyme;UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase (UDP-N-acetylmuramyl pentapeptide synthase): residues 1-451 are 65% similar to the enzyme in S.pneumoniae (gi15901505) and residues 1-450 are 64% similar to the protein in S.pyogenes (gi15675337). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0768 (1e-175).","

InterPro
IPR000713
Domain

Cytoplasmic peptidoglycan synthetase, N-terminal
PF01225	$\"[25-96]T$	Mur_ligase

InterPro
IPR004101
Domain

Cytoplasmic peptidoglycan synthetases, C-terminal
PF02875	$\"[306-394]T$	Mur_ligase_C

InterPro
IPR005863
Family

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase
PTHR23135:SF3	$\"[106-452]T$	MurF
TIGR01143	$\"[31-450]T$	murF

InterPro
IPR012237
Family

UDP-N-acetylmuramate-alanine ligase
PIRSF001562	$\"[6-452]T$	UDP-NAcM_Alig

InterPro
IPR013221
Domain

Mur ligase, middle region
PF08245	$\"[104-286]T$	Mur_ligase_M

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.10	$\"[82-304]T$	G3DSA:3.40.1190.10
G3DSA:3.40.1390.10	$\"[3-81]T$	G3DSA:3.40.1390.10
G3DSA:3.90.190.20	$\"[305-450]T$	G3DSA:3.90.190.20
PTHR23135	$\"[106-452]T$	PTHR23135
SSF53244	$\"[306-451]T$	SSF53244
SSF53623	$\"[100-304]T$	SSF53623
SSF63418	$\"[3-98]T$	SSF63418

","BeTs to 12 clades of COG0770COG name: UDP-N-acetylmuramyl pentapeptide synthaseFunctional Class: MThe phylogenetic pattern of COG0770 is -mt--qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 141-238 are 71% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS ENZYME) protein domain (PD212530) which is seen in Q9CIL4_LACLA.Residues 103-169 are 46% similar to a (LIGASE PROTEOME 6-DIAMINOPIMELATE--D-) protein domain (PD389998) which is seen in Q9WY78_THEMA.Residues 241-317 are 61% similar to a (ENZYME D-ALA-D-ALA ADDING PROTEOME) protein domain (PD212506) which is seen in Q9CIL4_LACLA.Residues 148-296 are 27% similar to a (PROTEOME COMPLETE UDP-MURNAC-PENTAPEPTIDE) protein domain (PD122291) which is seen in Q9ZLA3_HELPJ.Residues 31-92 are 69% similar to a (LIGASE SYNTHETASE CELL ENZYME) protein domain (PD006359) which is seen in Q9ZHC3_STRPN.Residues 103-206 are 38% similar to a (LIGASE PROTEOME 6-DIAMINOPIMELATE--D-) protein domain (PD286651) which is seen in Q9RWA1_DEIRA.Residues 318-451 are 60% similar to a (LIGASE CELL PROTEOME COMPLETE) protein domain (PD292385) which is seen in Q9ZHC3_STRPN.Residues 148-296 are 25% similar to a (PROTEOME COMPLETE UDP-MURNAC-PENTAPEPTIDE) protein domain (PD415597) which is seen in O25439_HELPY.Residues 94-140 are 82% similar to a (CELL ENZYME LIGASE) protein domain (PD383359) which is seen in Q9ZHC3_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 14:14:22 2006","Tue Mar 19 08:58:17 2002","Fri Sep 8 14:14:22 2006","Mon Dec 10 10:21:51 2001","","Mon Dec 10 10:21:51 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0549 is paralogously related (blast p-value < 1e-3) to SMu0498,a predicted UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase and SMu1529, a predicted UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate ligase","Tue Mar 19 08:58:17 2002","Fri Sep 8 14:14:22 2006","pdb1GG4A Chain A, Crystal Structure Of Escherichia Coli Udpmu... 194 2e-050","SMU.603","","Residues 38 to 297 (E-value = 1.3e-41) place SMu0549 in the Mur_ligase family which is described as Mur ligase family, catalytic domain (PF01225)Residues 306 to 396 (E-value = 9e-09) place SMu0549 in the Mur_ligase_C family which is described as Mur ligase family, glutamate ligase domain (PF02875)","Fri Sep 8 14:14:22 2006","24379080","","","Massidda,O., Anderluzzi,D., Friedli,L. and Feger,G.Unconventional organization of the division and cell wall genecluster of Streptococcus pneumoniaeMicrobiology 144 (Pt 11), 3069-3078 (1998)PubMed: 9846742Lugtenberg,E.J. and Schijndel-van Dam,A. v.Temperature-sensitive mutants of Escherichia coli K-12 with lowactivities of the L-alanine adding enzyme and theD-alanyl-D-alanine adding enzymeJ. Bacteriol. 110 (1), 35-40 (1972)PubMed: 4552998Eveland,S.S., Pompliano,D.L. and Anderson,M.S.Conditionally lethal Escherichia coli murein mutants contain pointdefects that map to regions conserved among murein and folylpoly-gamma-glutamate ligases: identification of a ligasesuperfamilyBiochemistry 36 (20), 6223-6229 (1997)PubMed: 9166795","","Mon Dec 10 10:54:57 2001","1","","9","SMU.603","321" "SMu0550","562431","562706","276","ATGAATAAGGTTTTTTGGAGTAAATTGTTTAATCACGAAGAAACTCTGCCATTAATTTTTATAAGTCATAATTCAAAAAATAGTAATTATGGTGACATTATAAAGGCATTGTTAATTGGTGTTGGTTTGCAGAACCATCAATTAATTTATACTTCAAGCTCTACAAATGGCATACCTGTTGGAAACAATATTTATGATTTTTTGCAAAAAGGACTTAGTTCAAAGCCAATTGTTTTATTTTTATTATCTCCAGAATATTTTTCGAGTGTTGTTTGA","9.20","1.70","10185","MNKVFWSKLFNHEETLPLIFISHNSKNSNYGDIIKALLIGVGLQNHQLIYTSSSTNGIPVGNNIYDFLQKGLSSKPIVLFLLSPEYFSSVV","562703","","conserved hypothetical protein","Membrane, Cytoplasm","A weak match in gapped BLAST to an hypothetical protein, yddK:residues 19-90 are 38% similar to Bacillus subtilis (gi|16077567|). No other hits at this time.SMu0550 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 19-90 are 38% similar to a (PROTEOME COMPLETE YDDK) protein domain (PD123631) which is seen in P96648_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 25 16:27:53 2002","Mon Oct 28 17:43:12 2002","Mon Oct 28 17:43:12 2002","Mon Dec 10 10:56:35 2001","","Mon Dec 10 10:56:35 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0550 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 10 10:58:38 2001","","No significant hits to the NCBI PDB database.","SMU.604","","No significant hits to the Pfam 11.0 database","Mon Dec 10 10:56:35 2001","24379081","","","","","","1","","9","SMU.604","" "SMu0551","562712","563263","552","ATGGGAGCAACTTGGGTGAAAAAGAATAATTATTTTATATTTTTTCTGCCAGGATTTAATCAAAGACAACAAGAATATTTGGATAGTTGTTTGGATAAAAATGTAAAGGGAATTTATCTGAATGGCGATAGTCGTTGTAAAAATGATTTGAAAAATTTTGTAAGAAAAATCATTAAAGAGTATATTGGAATTTGTGAAGAGGAGAGAATTGAGAGTGAAGTAGAAAGATGCTGTGATAAATTACATAAAATTTCTGTTATTGGTAAGCAATACACTGCTAAAATTACAAAAGTTAATAATAAAGTACATGATAATATTTTTTTAGAATTAGACACTTTGTTACCTACAGGTGAAGAATTTCATAAAGGTGAGAAACATTGGCTGCAACTGTATTTAAGAAATGAAAATTCTAATCTTCCAGATAAAATTGAAGAAGGGATGACAGTTACTTTTGTTCCTAAACAAATTACCTCTTTTGAGCGAAAAAAATACGGGAATCTTAATTTCAGAAATATCTATGCTGAATCTGGGACTGTTGAAATTTTTAGATAG","8.30","3.73","21569","MGATWVKKNNYFIFFLPGFNQRQQEYLDSCLDKNVKGIYLNGDSRCKNDLKNFVRKIIKEYIGICEEERIESEVERCCDKLHKISVIGKQYTAKITKVNNKVHDNIFLELDTLLPTGEEFHKGEKHWLQLYLRNENSNLPDKIEEGMTVTFVPKQITSFERKKYGNLNFRNIYAESGTVEIFR","563260","","hypothetical protein","Cytoplasm","No significant hit to gapped BLAST found.SMu0551 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 13:59:28 2002","Mon Dec 10 11:01:58 2001","Wed Jan 16 13:59:28 2002","Mon Dec 10 11:00:20 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0551 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 10 11:01:58 2001","","No significant hits to the NCBI PDB database.","SMU.605","","No significant hits to the Pfam 11.0 database","Mon Dec 10 11:00:20 2001","24379082","","","","","","1","","9","SMU.605","" "SMu0552","563276","564523","1248","GTGAATGGTAAAAAGTATTGTTTTGTTGTTATGGGATTTGGGAAGAAGACAGATCCCTACACTGGAAGAAATATTAATTTAGATGAAACATATGAAAAAGTTATCCAGCCTTTATTTTATGAGGAATTTCCGAATTTTGAATTAATTCGAGCGGATGAGTTAGTTGGCTCTAATGTTATTGACAAAAATATGTACAATTTATTGTTAAAAGCCGAACTTGTTATTGCAGATATTACAACTGATAATGCCAATGCACTTTATGAGCTTGGAGTTCGTCATGCACTTCGACCTTTTTCAACAATTATTATGTGTCAAAAAAGAGAAAGGGAGTTTGGCTTTGATTTAAATCATACGAGAATTCTTACATACAATAATTTTGGTGAAAAATTAGAATCTGATGAAAGTTTTCCAATAAGAAATAAATTGAAGAAATATGTTGAGGAAGCATTGTTAAACAAGCCCGAAGAAGAAAAAATAGACAGTCCATTTTACACCTATCTTCCTAAGGTAACCCCACCTTCCTATGATCAGGAATATCAATATAATGCTGTGAAAGCTACAAAAAATACAAAAATCATTGGAAATTTAATTAAATCTGCAAAGCAAGCAATGCTAGATAATGATTTTAAGCAAGCCAAAAAATATTGGAAACAGTTATCTCAAAAATCTCCAGATGAGATTTATTTCGTTCAGCAATTGGCTTTGGCGACTTATAAGTCTAAAGAACCAACTCAGACAGATGCGTTAATGGAAGCTTTAGAAATCATTAACAAACTTCCACTAGATAAAACCCTAGAGGTTGAAAGTTTAAGTATTGCTGCAGCAATCTATAAAAATTTATATCGTGTTAATAAAAATCCAGATTATTTAAGAAGGGCGATCGCTTTTTCTAAAAAAGCATATATTGTGACAAATGACTACTATCCTGGGGAAAATTATATCAATTGTTTACTTTTGGAAGCTTTTAATTATTCAAAAGATGAAGAGAAAGTTTGCTATGCTAAACTTGAAGCTCAGAAGACCTATAAAGAATTATTAAAAATTATTAAAAATAATGACGATGAGGATGATTATTGGAAGTATGCTACTCAAGCCGTTGCTTATAAATTTTTTAATAAAGAAAGTGACTATTTAACAAGTAAAAGCACATTCGAAAGTAAATGTCAAAGTGATTGGGAGAAACTGACTTTTAATAATACTATTTCTGAATTAGAAGAAATTAAGCGAGTTTTATTTTCAAATAATTAG","5.80","-2.71","48513","MNGKKYCFVVMGFGKKTDPYTGRNINLDETYEKVIQPLFYEEFPNFELIRADELVGSNVIDKNMYNLLLKAELVIADITTDNANALYELGVRHALRPFSTIIMCQKREREFGFDLNHTRILTYNNFGEKLESDESFPIRNKLKKYVEEALLNKPEEEKIDSPFYTYLPKVTPPSYDQEYQYNAVKATKNTKIIGNLIKSAKQAMLDNDFKQAKKYWKQLSQKSPDEIYFVQQLALATYKSKEPTQTDALMEALEIINKLPLDKTLEVESLSIAAAIYKNLYRVNKNPDYLRRAIAFSKKAYIVTNDYYPGENYINCLLLEAFNYSKDEEKVCYAKLEAQKTYKELLKIIKNNDDEDDYWKYATQAVAYKFFNKESDYLTSKSTFESKCQSDWEKLTFNNTISELEEIKRVLFSNN","564520","","hypothetical protein","Cytoplasm","No significant hit to gapped BLAST found.SMu0552 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","BeTs to 3 clades of COG0457COG name: TPR-repeat-containing proteinsFunctional Class: RThe phylogenetic pattern of COG0457 is AMTKYQVCEB-HUJ--OLINXNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 14:00:01 2002","Mon Dec 10 11:03:33 2001","Wed Jan 16 14:00:01 2002","Mon Dec 10 11:03:33 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0552 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 14:00:01 2002","","No significant hits to the NCBI PDB database.","SMU.606","","No significant hits to the Pfam 11.0 database","Mon Dec 10 11:03:33 2001","24379083","","","","","","1","","9","SMU.606","" "SMu0553","564579","565262","684","ATGACCGATTTTTTTACAACTGTTCAGACAAGCCCACCATCCATTTCAATACCGCTTTATTTGCTGATGTTTGTAGTTTTGCTAGGTCTCATTTGGTTATCTGTTACTTATTATCGGAAGCAGTGGTTGTGGTGTATTTATCATTTTTTACAGAGCTTTCAGTTACTTTCACTCTATATTTGGTATGGGGCGAAAATGATTCCAATTTCCAATAGTTTGCCGTTTTATCATTGTCGTCTTGCTATGTTTGCCCTTTTATTGCTACCGGATAAAACGAAATTGAAGCAGTATTTTGCACTTATGGGAGTTAGTGGTGCTATTTTTGCTATTGGTTACCCTATTATGGATGCTTATACTTTTCCACATATTACTGCTTTTTCATTTCTCATTGGACACTATGCTCTTTTGGTTGGAAGTATTATTTACCTTATGCGTTATTATAAGTCAAATTTTCTCAGTTGGAAAGCTATTATTCTCTACACGTTTGTTTTAAACCTCTTTTTGGTGATTATTAATTATTTGACCGGCGGCAATTATGGGATCTTGCGTTACACACCTTTTATTACCAATACGCCACTCCTAGTGCGCTATCTAGCTGTAACCTTTATTTTAACTGCCATGTTGCTGCTAATTGATTGGGTATTTATCAGGAGGGAATATGGAAAAGCAAGAGCAGAAAGATAA","10.50","11.84","26548","MTDFFTTVQTSPPSISIPLYLLMFVVLLGLIWLSVTYYRKQWLWCIYHFLQSFQLLSLYIWYGAKMIPISNSLPFYHCRLAMFALLLLPDKTKLKQYFALMGVSGAIFAIGYPIMDAYTFPHITAFSFLIGHYALLVGSIIYLMRYYKSNFLSWKAIILYTFVLNLFLVIINYLTGGNYGILRYTPFITNTPLLVRYLAVTFILTAMLLLIDWVFIRREYGKARAER","565259","","conserved hypothetical protein","Membrane, Cytoplasm, Extracellular","Limited matches in gapped BLAST to hypothetical proteins:residues 4-210 are 42% similar to S.pneumoniae (gi|15901503|) and residues 3-224 are 31% similar to S.pyogenes (gi|15675336|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0770 (2e-33).","

InterPro
IPR011737
Family

Conserved hypothetical protein 2206
TIGR02206	$\"[5-219]T$	intg_mem_TP0381

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-210 are 42% similar to a (DOMAIN OF UNKNO N) protein domain (PD211238) which is seen in Q9ZHC1_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 14:00:35 2002","Mon Dec 10 14:18:19 2001","Wed Jan 16 14:00:35 2002","Mon Dec 10 11:06:50 2001","","Mon Dec 10 11:06:50 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0553 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 10 11:07:18 2001","","No significant hits to the NCBI PDB database.","SMU.607","","No significant hits to the Pfam 11.0 database","Mon Dec 10 11:06:50 2001","24379084","","","","","","1","","9","SMU.607","917" "SMu0554","565446","566990","1545","ATGAACTTACAAGAAGAAATTAAGAAACGTCGAACCTTTGCCATCATTTCCCACCCGGATGCTGGTAAGACGACGATTACGGAGCAGTTGCTCTATTTTGGAGGTGAAATCCGAGAGGCTGGTACTGTTAAAGGAAAGAAAACCGGTAATTTTGCCAAATCTGACTGGATGGATATTGAAAAACAGCGTGGGATTTCCGTAACTTCATCTGTCATGCAGTTTGACTATGCGGGTAAGCGGGTCAATATCCTTGATACACCTGGGCATGAGGACTTTTCTGAGGATACTTACCGAACACTAATGGCGGTAGATGCTGCTGTTATGGTCGTGGACTCTGCCAAGGGGATCGAAGCACAGACAAAAAAGCTTTTTGAAGTTGTCAAGCATCGTGGTATCCCTATCTTTACTTTTATCAATAAATTGGACCGTGATGGTCGCGAACCGCTGGATTTATTGGAAGAATTAGAAGAGGTATTGGGGATTGCTTCTTATCCTATGAATTGGCCTATTGGTATGGGAAGATCTTTTGAGGGGCTCTATGATTTGTACAATCAGCGTCTTGAACTCTACAAAGGTGATGAGCGTTTTGCTTCTATTGAAGATGGTGACAAGCTCTTTGCTAATAATCCCTTCTATGAACAAGCTAAAGAAGATATTGAACTTTTGACTGAAGCGGGAAATGAATTTTCAGAAGAAGCCATTTTAAAGGGTGAGCTGACGCCTGTCTTCTTTGGCTCAGCCCTAACCAACTTTGGTGTTCAAACTTTCTTGGATTCTTTCTTAGCATTTGCACCAGAACCACACGGTCACAAGACCACTGACGATAAGGTGATTGATCCTTTAGATAAAGACTTTTCAGGCTTTGTTTTTAAAATCCAAGCTAATATGGATCCTCGCCACCGAGATCGTATTGCCTTTGTGCGGATTGTCTCAGGTGAATTTGAACGCGGCATGTCTGTCAACCTTGCCCGCACTGGTAAGAGCGTTAAGCTGTCAAACGTCACTCAGTTTATGGCAGAATCTCGTGAGAATGTAGAAAATGCTGTCGCTGGTGATATTATCGGAGTTTACGATACAGGAACTTATCAGGTTGGTGATACCCTAACTGTTGGTAAAAATAAATTTGAATTTGAGCCACTGCCGACCTTTACACCAGAGCTCTTTATGAAAGTTTCTGCTAAAAATGTTATGAAGCAGAAGTCTTTTCATAAAGGCATTGAGCAATTGGTGCAAGAAGGTGCTATACAGCTTTATACCAACTATCAAACTGGTGAATATATGCTTGGAGCAGTCGGTCAGCTCCAGTTTGAAGTTTTCAAACACCGCATGGAAAATGAATACAATGCGGAGGTTATCATGACACCCATGGGTAAGAAAACGGTGCGTTGGATTAAGGAGGAAGATCTTGATGAACGTATGTCTTCCAGCCGCAATATATTGGCTAAAGACCGCTTTAACAAGCCCGTTTTCCTCTTTGAAAATGACTTTTCTCTTCATTGGTTTGCAGATAAATATCCAGATATAGTTTTGGAAGAGAAGATGTAA","4.90","-17.76","58555","MNLQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVKGKKTGNFAKSDWMDIEKQRGISVTSSVMQFDYAGKRVNILDTPGHEDFSEDTYRTLMAVDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPIFTFINKLDRDGREPLDLLEELEEVLGIASYPMNWPIGMGRSFEGLYDLYNQRLELYKGDERFASIEDGDKLFANNPFYEQAKEDIELLTEAGNEFSEEAILKGELTPVFFGSALTNFGVQTFLDSFLAFAPEPHGHKTTDDKVIDPLDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLARTGKSVKLSNVTQFMAESRENVENAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPELFMKVSAKNVMKQKSFHKGIEQLVQEGAIQLYTNYQTGEYMLGAVGQLQFEVFKHRMENEYNAEVIMTPMGKKTVRWIKEEDLDERMSSSRNILAKDRFNKPVFLFENDFSLHWFADKYPDIVLEEKM","566987","For other 'prf' genes see SMu0993 (prfA) and SMu1211 (prfB).From Genbank:[gi:13878664]This protein increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.It binds guanine nucleotides and has strong preference for UGA stop codons.It may interact directly with the ribosome.The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP,but not by GMP.","peptide chain release factor 3 ; translation elongation and release factor","Cytoplasm","Matches in gapped BLAST to translation elongation factor EF-G homolog:residues 1-514 are 99% similar to the previously published protein in S.mutans (gi280249). Residues 1-514 are 87% similar to peptide chain release factor 3 in S.pneumoniae (gi15900357) and are 86% similar to the protein from S.pyogenes (gi15675335).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0772 (0.0).","

InterPro
IPR000795
Domain

Protein synthesis factor, GTP-binding
PR00315	$\"[12-25]T$ $\"[62-70]T$ $\"[82-92]T$ $\"[98-109]T$ $\"[134-143]T$	ELONGATNFCT
PF00009	$\"[8-268]T$	GTP_EFTU
PS00301	$\"[55-70]T$	EFACTOR_GTP

InterPro
IPR002127
Family

Tetracycline-resistance protein
PR01037	$\"[120-143]T$ $\"[239-261]T$	TCRTETOQM

InterPro
IPR004161
Domain

Translation elongation factor EFTu/EF1A, domain 2
PF03144	$\"[302-369]T$	GTP_EFTU_D2

InterPro
IPR004548
Family

Peptide chain release factor 3
TIGR00503	$\"[2-513]T$	prfC

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[8-185]T$	small_GTP

InterPro
IPR009000
Domain

Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447	$\"[250-379]T$	Translat_factor

InterPro
IPR009022
Domain

Elongation factor G, III and V
SSF54980	$\"[380-455]T$	EFG_III_V

noIPR
unintegrated

unintegrated
G3DSA:2.40.30.10	$\"[282-379]T$	G3DSA:2.40.30.10
G3DSA:3.30.70.870	$\"[381-458]T$	G3DSA:3.30.70.870
G3DSA:3.40.50.300	$\"[2-270]T$	G3DSA:3.40.50.300
PTHR23115	$\"[1-161]T$ $\"[226-402]T$	PTHR23115
PTHR23115:SF13	$\"[1-161]T$ $\"[226-402]T$	PTHR23115:SF13
SSF52540	$\"[1-274]T$	SSF52540

","BeTs to 17 clades of COG0480COG name: Translation elongation and release factors (GTPases)Functional Class: JThe phylogenetic pattern of COG0480 is amtkYqVCEbRHujgpOLinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000640 (Elongation factor G, C-terminus) with a combined E-value of 1e-37. IPB000640A 10-35 IPB000640B 54-76 IPB000640C 81-108 IPB000640D 115-143***** IPB000795 (GTP-binding elongation factor) with a combined E-value of 2.2e-19. IPB000795A 12-27 IPB000795B 84-115 IPB000795C 119-143***** IPB000178 (Initiation factor 2) with a combined E-value of 1.1e-12. IPB000178A 9-47 IPB000178B 81-113 IPB000178C 114-153","Residues 114-191 are 41% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in RF3_BUCAI.Residues 93-181 are 62% similar to a (FACTOR RELEASE GTP-BINDING CHAIN) protein domain (PD013442) which is seen in RF3_LACLA.Residues 413-510 are 77% similar to a (RELEASE PEPTIDE FACTOR CHAIN) protein domain (PD013443) which is seen in RF3_LACLA.Residues 234-368 are 83% similar to a (RESISTANCE GTP-BINDING BIOSYNTHESIS ANTIBIOTIC) protein domain (PD002777) which is seen in RF3_LACLA.Residues 60-92 are 96% similar to a (FACTOR GTP-BINDING BIOSYNTHESIS) protein domain (PD336744) which is seen in RF3_LACLA.Residues 1-58 are 91% similar to a (FACTOR ELONGATION GTP-BINDING) protein domain (PD334795) which is seen in RF3_LACLA.Residues 413-510 are 56% similar to a (PEPTIDE GTP-BINDING FACTOR CHAIN) protein domain (PD396095) which is seen in RF3_STAAU.Residues 11-92 are 34% similar to a (G GTP-BINDING FACTOR ELONGATION) protein domain (PD249398) which is seen in EFGL_THEMA.Residues 11-46 are 72% similar to a (GTP-BINDING FACTOR ELONGATION BIOSYNTHESIS RESISTANCE) protein domain (PD000122) which is seen in RF3_SYNY3.Residues 371-412 are 83% similar to a (GTP-BINDING FACTOR CHAIN RELEASE) protein domain (PD410050) which is seen in RF3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 08:52:33 2006","Tue Oct 8 09:48:11 2002","Tue Aug 1 08:52:33 2006","Mon Dec 10 11:10:52 2001","Mon Dec 10 11:10:52 2001","Mon Dec 10 11:10:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0554 is paralogously related (blast p-value < 1e-3) to SMu0324,a predicted translation elongation factor G, SMu1271 and SMu0496, both predicted GTP-binding proteins, SMu0382,a predicted translation initiation factor, SMu0651,a predicted translation elongation factor EF-Tu, and SMu1471,a predicted GTP-binding protein Era homolog.","Tue Jan 15 08:36:44 2002","Tue Aug 1 08:52:33 2006","pdb1FNMA Chain A, Structure Of Thermus Thermophilus Ef-G H573a 182 9e-047pdb1ELO Elongation Factor G Without Nucleotide >gi1633250... 182 9e-047pdb2EFGA Chain A, Translational Elongation Factor G Complexed... 180 4e-046","SMU.608","","Residues 8 to 268 (E-value = 2.9e-67) place SMu0554 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)Residues 302 to 369 (E-value = 6.6e-13) place SMu0554 in the GTP_EFTU_D2 family which is described as Elongation factor Tu domain 2 (PF03144)","Tue Aug 1 08:52:33 2006","24379085","","Ogier,J.A., Scholler,M., Lepoivre,Y., Gangloff,S., M'Zoughi,R. andKlein,J.P.A 40-kilodalton cell wall protein-coding sequence upstream of thesr gene of Streptococcus mutans OMZ175 (serotype f)Infect. Immun. 59 (5), 1620-1626 (1991)PubMed: 2019433LeBlanc,D.J., Lee,L.N., Titmas,B.M., Smith,C.J. and Tenover,F.C.Nucleotide sequence analysis of tetracycline resistance gene tetOfrom Streptococcus mutans DL5J. Bacteriol. 170 (8), 3618-3626 (1988)PubMed: 2841293","Kawazu,Y., Ito,K., Matsumura,K. and Nakamura,Y.Comparative characterization of release factor RF-3 genes ofEscherichia coli, Salmonella typhimurium, and Dichelobacter nodosusJ. Bacteriol. 177 (19), 5547-5553 (1995)PubMed: 7559341Mikuni,O., Ito,K., Moffat,J., Matsumura,K., McCaughan,K.,Nobukuni,T., Tate,W. and Nakamura,Y.Identification of the prfC gene, which encodespeptide-chain-release factor 3 of Escherichia coliProc. Natl. Acad. Sci. U.S.A. 91 (13), 5798-5802 (1994)PubMed: 8016068Grentzmann,G., Brechemier-Baey,D., Heurgue,V., Mora,L. andBuckingham,R.H.Localization and characterization of the gene encoding releasefactor RF3 in Escherichia coliProc. Natl. Acad. Sci. U.S.A. 91 (13), 5848-5852 (1994)PubMed: 8016077Mortensen,K.K., Hansen,H.F., Grentzmann,G., Buckingham,R.H. andSperling-Petersen,H.U.Osmo-expression and fast two-step purification of Escherichia colitranslation termination factor RF-3Eur. J. Biochem. 234 (3), 732-736 (1995)PubMed: 8575429Grentzmann,G., Brechemier-Baey,D., Heurgue-Hamard,V. andBuckingham,R.H.Function of polypeptide chain release factor RF-3 in Escherichiacoli. RF-3 action in termination is predominantly at UGA-containing stop signalsJ. Biol. Chem. 270 (18), 10595-10600 (1995)PubMed: 7737996","Tue Aug 1 08:52:33 2006","Mon Dec 10 12:42:54 2001","1","","","SMU.608","83" "SMu0555","567244","569079","1836","ATGAAAAGAATTGATATTAATCATCAAGCACAACGTTTTTCTATTCGCAAATATGCATTTGGAGCTGCATCTGTTTTAATTGGCTGTGTCTTTTTTCTAGGTACCCAAAATGTTTCTGCACAAGAGCAGGGAACTCAATTGCCAGCAAGTGAAAACGCAGTTGTGAACGTGGCTGAAAATTCAGTTGCTATCAGCCAAGCAGTTTCAGATAAGGCAGCAGCTCAAACAACTCTAACAGAAACACCCCAAGTTGAAGTTGAGGAGAAAGAAAATAAGGTAAATGCTCCTGCTTTAAATGTCGATGACAAAGGTGCAAAATCCAAAGAAGATGTGAACCCTACTGTTTCAAAGACAGCAAGTGAAGTGGAAGCTTCTGCAGTAACTGCTACTGATACTAAAAATTCAAATCCACAAGTCAATGTTGAAACTGACTCAAATGAAAAAGACGAAAATAAAATGGTCACCTCGGCTCCAGCTAAGGAGACTGAGGCAGAACAAAATGAGAAAGCGGTAGCAGAAAATCTTATGCAAAGACAAGCTAAGGCTGTCTCAATTCCATCGCAAGGCAATTATGTTTTCCAAGAAACAACTCCTGTAAAAAATGCAGCCAGTATGTCCAGCCCAACCCAATTTAACTTTGATAAAGGAGATAAGGTTTTTTATGATAAGGTTTTAGAAGCGGATGGGCATCAATGGATTAGCTATGTGTCTTACAGTGGTATTCGTCGCTATGCTCCTATTGCTGTGACAATTGAAGAATTGAAGCAAAAAGAAATTGTTCAGCAAAATTTACCGGCACAAGGAACCTATCACTTTACTAAACAAGCAGACGTTAAAAATGAAGCTAAACTGTCTAGTCCGACCCAATTCTCGTTTTACAACGGAGATCACGTTTTTTATGATAAGGTTTTAGAAGCGGATGGGCATCAATGGATTAGCTATGTGTCCTACAGTGGTATCCGTCGTTATGTTGTTATTGGAAAGCTTACGACACAACCCTCTCCAATTGAAACTAAAGTATCAGGTACTATTGCCATCCAAAATAAAACGGCTCAACAATTCGATGTTATCATTTCTAATGTTTCCAGCACTCAAGGCATAAAAGAGGTATTAGTGCCGGTTTGGTCAGAGCAAAACGGGCAGGATGACATTGTCTGGTATCAAGCAACTAAACAAGGCGAAGGCGTTTATAAGGTGACCGTTAAGGTCAGTGACCATAAAAATAACAGTGGTAACTATGACATTCACCTTTATTATCGCCTTTCAACTGGTGAATTAAAGGTTGTTGGAGGAAAGACAACTGAGGTGGAAGCACCGAAGCCTGTAGAAACAACAGGTATCATTAGCATTGCCAATAAGAGCAGCCAAGGATTTGATGTTTTGATTACTAATGCTTCCAGCACTCAAGGCATAAAAGAGGTATTAGTGCCAGTTTGGTCAGAACAAAACGGACAGGACGATATTATTTGGTATCAAGCAACTAAACAAGGCGAAGGCGTTTATAAGGTGACCGTTAAGGTCAGTGACCATAAAAATGACAGTGGTAACTATGACATTCACCTTTATTATCGCCTTTCAACTGGTGAATTAAAGGTTGTTGGAGGAAAGACAACGACAGTAGAAGCCCCTAATAGAGTCAATCTTCCAGCACAAGGAACTTATGTTTTCACTAATAAAGTTGAGGTTAAAAATGAGGCCAGAACATCTAGTCCAACTCAGTTTACCTTTAATAAAGGAGAAAGTATTTACTATGACAGTATCTTGAATGCTGATGGACATCAATGGATTAGCTATCGTTCCTACAGTGGTATTCGTCGTTATATTATCATTGATTGA","5.80","-7.58","67449","MKRIDINHQAQRFSIRKYAFGAASVLIGCVFFLGTQNVSAQEQGTQLPASENAVVNVAENSVAISQAVSDKAAAQTTLTETPQVEVEEKENKVNAPALNVDDKGAKSKEDVNPTVSKTASEVEASAVTATDTKNSNPQVNVETDSNEKDENKMVTSAPAKETEAEQNEKAVAENLMQRQAKAVSIPSQGNYVFQETTPVKNAASMSSPTQFNFDKGDKVFYDKVLEADGHQWISYVSYSGIRRYAPIAVTIEELKQKEIVQQNLPAQGTYHFTKQADVKNEAKLSSPTQFSFYNGDHVFYDKVLEADGHQWISYVSYSGIRRYVVIGKLTTQPSPIETKVSGTIAIQNKTAQQFDVIISNVSSTQGIKEVLVPVWSEQNGQDDIVWYQATKQGEGVYKVTVKVSDHKNNSGNYDIHLYYRLSTGELKVVGGKTTEVEAPKPVETTGIISIANKSSQGFDVLITNASSTQGIKEVLVPVWSEQNGQDDIIWYQATKQGEGVYKVTVKVSDHKNDSGNYDIHLYYRLSTGELKVVGGKTTTVEAPNRVNLPAQGTYVFTNKVEVKNEARTSSPTQFTFNKGESIYYDSILNADGHQWISYRSYSGIRRYIIID","569076","This sequence should not be confused with the \"cbpD\" sequence (choline binding protein) of S.pneumoniae the similarity is fragmentary and weak.","cell wall protein precursor","Extracellular","This sequence was previously published in GenBank (gi280247, gi280251) and defined as a 40K cell wall protein precursor (sr 5' region) and hypothetical protein 2 (sr 5' region) respectively. Residues 1-279 are 87% and residues 434-595 are 96% similar to the published sequence from S.mutans (gi280247).Residues 184-430 and residues 261-359 are 29% similar to choline binding protein D from S.pneumoniae gi15904047.This sequence is similar to Spy0031, a conserved hypothetical. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1350 (5e-82).","

InterPro
IPR003646
Domain

Bacterial SH3-like region
SM00287	$\"[187-253]T$ $\"[267-333]T$ $\"[550-608]T$	SH3b

InterPro
IPR005877
Domain

YSIRK Gram-positive signal peptide
PF04650	$\"[7-33]T$	YSIRK_signal
TIGR01168	$\"[1-43]T$	YSIRK_signal

InterPro
IPR013667
Domain

SH3, type-5 bacterial
PF08460	$\"[183-247]T$ $\"[262-326]T$ $\"[546-610]T$	SH3_5

InterPro
IPR013688
Repeat

GBS Bsp-like
PF08481	$\"[343-436]T$ $\"[448-540]T$	GBS_Bsp-like

noIPR
unintegrated

unintegrated
PS51257	$\"[1-29]T$	PROKAR_LIPOPROTEIN

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 184-331 are 32% similar to a (D CHOLINE BINDING) protein domain (PD303800) which is seen in Q9KGZ2_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 10:52:33 2006","Thu Sep 14 10:51:14 2006","Thu Sep 14 10:52:33 2006","Mon Dec 10 12:44:01 2001","","Mon Dec 10 12:44:01 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0555 is paralogously related (blast p-value < 1e-3) to SMu0760 and SMu0018,both predicted glucan-binding protein B;immunodominant glycoprotein IDG-60; general stress protein GSP-781, SMu0630,a predicted hypothetical protein, SMu1843,a predicted levansucrase (fructosyltransferase) (beta-D-fructofuranosyl transferase) SMu0700,a predicted BglB-like protein, SMu1916,a predicted glucan-binding protein,and finally to SMu0827,a predicted glucosyltransferase-S.","Tue Jan 15 09:56:04 2002","","No significant hits to the NCBI PDB database.","SMU.609","","Residues 7 to 33 (E-value = 5.1e-09) place SMu0555 in the YSIRK_signal family which is described as YSIRK type signal peptide (PF04650)","Mon Dec 10 12:44:01 2001","24379086","","Ogier,J.A., Scholler,M., Lepoivre,Y., Gangloff,S., M'Zoughi,R. andKlein,J.P.A 40-kilodalton cell wall protein-coding sequence upstream of thesr gene of Streptococcus mutans OMZ175 (serotype f)Infect. Immun. 59 (5), 1620-1626 (1991)PubMed: 2019433","Gosink,K.K., Mann,E.R., Guglielmo,C., Tuomanen,E.I. and Masure,H.R.Role of novel choline binding proteins in virulence ofStreptococcus pneumoniaeInfect. Immun. 68 (10), 5690-5695 (2000)PubMed: 10992472","Thu Sep 14 10:52:33 2006","Tue Jan 15 10:08:55 2002","1","","","SMU.609","941" "SMu0556","569317","574005","4689","ATGAAAGTCAAAAAAACTTACGGTTTTCGTAAAAGTAAAATTAGTAAAACACTGTGTGGTGCTGTTCTAGGAACAGTAGCAGCAGTCTCTGTAGCAGGACAAAAGGTTTTTGCCGATGAAACGACCACTACTAGTGATGTAGATACTAAAGTAGTTGGAACACAAACTGGAAATCCAGCGACCAATTTGCCAGAGGCTCAAGGGAGTGCGAGTAAGGAAGCTGAACAAAGTCAAAACCAAGCTGGAGAGACAAATGGTTCAATACCAGTTGAAGTACCTAAAACTGATCTTGATCAAGCAGCAAAAGATGCTAAGTCTGCTGGTGTCAATGTTGTCCAAGATGCCGATGTTAATAAAGGAACTGTTAAAACAGCTGAAGAAGCAGTCCAAAAAGAAACTGAAATTAAAGAAGATTACACAAAACAAGCTGAGGATATTAAGAAGACAACAGATCAATATAAATCGGATGTAGCTGCTCATGAGGCAGAAGTTGCTAAAATCAAAGCTAAAAATCAGGCAACTAAAGAACAGTATGAAAAAGATATGGCAGCTCATAAAGCCGAGGTTGAACGCATTAATGCTGCAAATGCTGCCAGTAAAACAGCTTATGAAGCTAAATTGGCTCAATATCAAGCAGATTTAGCAGCCGTTCAAAAAACCAATGCTGCCAATCAAGCAGCCTATCAAAAAGCCCTTGCTGCTTATCAGGCTGAACTGAAACGTGTTCAGGAAGCTAATGCAGCCGCCAAAGCCGCTTATGATACTGCTGTAGCAGCAAATAATGCTAAAAATACAGAAATTGCCGCTGCCAATGAAGAAATTAGAAAACGCAATGCAACGGCCAAAGCTGAATATGAGACTAAGTTAGCTCAATATCAAGCTGAACTAAAGCGTGTTCAGGAAGCTAATGCCGCAAACGAAGCAGACTATCAAGCTAAATTGACCGCCTATCAAACAGAGCTTGCTCGCGTTCAAAAAGCCAATGCGGATGCTAAAGCGGCCTATGAAGCAGCTGTAGCAGCAAATAATGCCAAAAATGCGGCACTCACAGCTGAAAATACTGCAATTAAGCAACGCAATGAGAATGCTAAGGCGACTTATGAAGCTGCACTCAAGCAATATGAGGCCGATTTGGCAGCGGTGAAAAAAGCTAATGCCGCAAACGAAGCAGACTATCAAGCTAAATTGACCGCCTATCAAACAGAGCTCGCTCGCGTTCAAAAAGCCAATGCGGATGCTAAAGCGGCCTATGAAGCAGCTGTAGCAGCAAATAATGCCGCAAATGCAGCGCTCACAGCTGAAAATACTGCAATTAAAAAGCGCAATGCGGATGCTAAAGCTGATTACGAAGCAAAACTTGCTAAGTATCAAGCAGATCTTGCCAAATATCAAAAAGATTTAGCAGACTATCCAGTTAAGTTAAAGGCATACGAAGATGAACAAGCTTCTATTAAAGCTGCACTGGCAGAGCTTGAAAAACATAAAAATGAAGACGGAAACTTAACAGAACCATCTGCTCAAAATTTGGTCTATGATCTTGAGCCAAATGCGAACTTATCTTTGACAACAGATGGGAAGTTCCTTAAGGCTTCTGCTGTGGATGATGCTTTTAGCAAAAGCACTTCAAAAGCAAAATATGACCAAAAAATTCTTCAATTAGATGATCTAGATATCACTAACTTAGAACAATCTAATGATGTTGCTTCTTCTATGGAGCTTTATGGGAATTTTGGTGATAAAGCTGGCTGGTCAACGACAGTAAGCAATAACTCACAGGTTAAATGGGGATCGGTACTTTTAGAGCGCGGTCAAAGCGCAACAGCTACATACACTAACCTGCAGAATTCTTATTACAATGGTAAAAAGATTTCTAAAATTGTCTACAAGTATACAGTGGACCCTAAGTCCAAGTTTCAAGGTCAAAAGGTTTGGTTAGGTATTTTTACCGATCCAACTTTAGGTGTTTTTGCTTCCGCTTATACAGGTCAAGTTGAAAAAAACACTTCTATTTTTATTAAAAATGAATTCACTTTCTATGACGAAGATGGAAAACCAATTAATTTTGATAATGCCCTTCTATCAGTAGCTTCTCTTAACCGTGAAAATAATTCTATTGAGATGGCCAAAGATTATACGGGTAAATTTGTCAAAATCTCTGGATCATCTATCGGTGAAAAGAATGGCATGATTTATGCTACAGATACTCTCAACTTTAGGCAGGGTCAAGGTGGTGCTCGTTGGACCATGTATACCAGAGCTAGCGAACCGGGATCTGGCTGGGATAGTTCAGATGCGCCTAACTCTTGGTATGGTGCTGGTGCTATCCGCATGTCTGGTCCTAATAACAGTGTGACTTTGGGTGCTATCTCATCAACACTTGTTGTGCCTGCTGATCCTACAATGGCAATTGAAACTGGCAAAAAACCAAATATTTGGTATTCTTTAAATGGTAAAATCCGTGCGGTTAATGTTCCTAAAGTTACCAAGGAAAAACCCACACCGCCGGTTAAACCAACAGCTCCAACTAAACCAACTTATGAAACAGAAAAGCCATTAAAACCGGCACCAGTAGCTCCAAATTATGAAAAGGAGCCAACACCGCCGACAAGGACACCGGATCAAGCAGAGCCAAACAAACCCACACCGCCGACCTATGAAACAGAAAAGCCGTTGGAGCCAGCACCTGTTGAGCCAAGCTATGAAGCAGAGCCAACACCGCCGACAAGGACACCGGATCAGGCAGAGCCAAATAAACCCACACCGCCGACCTATGAAACAGAAAAGCCGTTGGAGCCAGCACCTGTTGAGCCAAGCTATGAAGCAGAGCCAACGCCACCGACACCAACACCAGATCAACCAGAACCAAACAAACCTGTTGAGCCAACTTATGAGGTTATTCCAACACCGCCGACTGATCCTGTTTATCAAGATCTTCCAACACCTCCATCTGTACCAACTGTTCATTTCCATTACTTTAAACTAGCTGTTCAGCCGCAGGTTAACAAAGAAATTAGAAACAATAACGATATTAATATTGACAGAACTTTGGTGGCTAAACAATCTGTTGTTAAGTTCCAGCTGAAGACAGCAGATCTCCCTGCTGGACGTGATGAAACAACTTCCTTTGTCTTGGTAGATCCCCTGCCATCTGGTTATCAATTTAATCCTGAAGCTACAAAAGCTGCAAGCCCTGGCTTTGATGTCACTTATGATAATGCAACTAATACAGTCACCTTCAAGGCAACTGCAGCAACTTTGGCTACGTTTAATGCTGATTTGACTAAGTCAGTGGCAACGATTTATCCAACAGTGGTCGGACAAGTTCTTAATGATGGCGCAACTTATAAGAATAATTTCACGCTCACAGTCAATGATGCTTATGGCATTAAATCCAATGTTGTTCGGGTGACAACTCCTGGTAAACCAAATGATCCAGATAATCCAAATAATAATTATATTAAACCAACTAAGGTTAATAAAAACGAAAATGGCGTTGTTATTGATGGTAAAACAGTTCTTGCCGGTTCAACGAATTATTATGAGCTAACTTGGGATTTGGATCAATATAAAAACGACCGCTCTTCAGCAGATACCATTCAAAAAGGATTTTACTATGTAGATGATTATCCAGAAGAAGCGCTTGAATTGCGTCAGGATTTAGTGAAGATTACAGATGCTAATGGTAATGAAGTTACTGGTGTTAGTGTGGATAATTATACTAATCTTGAAGCAGCCCCTCAAGAAATTAGAGATGTTCTTTCTAAGGCAGGAATTAGACCTAAAGGTGCTTTCCAAATTTTCCGTGCCGATAATCCAAGAGAATTTTATGATACTTATGTCAAAACTGGAATTGATTTGAAGATTGTATCACCAATGGTTGTTAAAAAACAAATGGGACAAACAGGCGGCAGTTATGAAAATCAAGCTTACCAAATTGACTTTGGTAATGGTTATGCATCAAATATCATTATCAATAATGTTCCTAAGATTAACCCTAAGAAAGATGTGACCTTAACACTTGATCCGGCTGATACAAATAATGTTGATGGTCAGACTATTCCACTTAATACAGTCTTTAATTACCGTTTGATTGGTGGCATTATCCCTGCAGATCACTCAGAAGAACTCTTTGAATACAATTTTTATGATGATTATGATCAAACAGGAGATCACTATACTGGTCAGTATAAAGTTTTTGCTAAGGTTGATATCACTTTTAAAGACGGTTCTATTATCAAGTCAGGTGCTGAGTTAACTCAGTATACGACAGCGGAAGTTGATACCGCTAAAGGTGCTATCACAATTAAGTTCAAGGAAGCCTTTCTGCGTTCTGTTTCAATTGATTCAGCCTTCCAAGCTGAAAGTTATATCCAAATGAAACGTATTGCGGTTGGTACTTTTGAAAATACTTATATTAATACTGTCAATGGGGTAACTTACAGTTCAAATACAGTGAAAACAACTACTCCTGAGGATCCTACAGACCCTACTGATCCGCAAGATCCATCATCACCGCGGACTTCAACTGTAATTAACTACAAACCTCAATCAACTGCTTATCAACCAAGCTCTGTTCAAGAAACATTACCAAATACGGGAGTAACAAACAATGCTTATATGCCTTTACTTGGTATTATTGGCTTAGTTACTAGTTTTAGTTTGCTTGGCTTAAAGGCTAAGAAAGATTGA","5.00","-26.16","169977","MKVKKTYGFRKSKISKTLCGAVLGTVAAVSVAGQKVFADETTTTSDVDTKVVGTQTGNPATNLPEAQGSASKEAEQSQNQAGETNGSIPVEVPKTDLDQAAKDAKSAGVNVVQDADVNKGTVKTAEEAVQKETEIKEDYTKQAEDIKKTTDQYKSDVAAHEAEVAKIKAKNQATKEQYEKDMAAHKAEVERINAANAASKTAYEAKLAQYQADLAAVQKTNAANQAAYQKALAAYQAELKRVQEANAAAKAAYDTAVAANNAKNTEIAAANEEIRKRNATAKAEYETKLAQYQAELKRVQEANAANEADYQAKLTAYQTELARVQKANADAKAAYEAAVAANNAKNAALTAENTAIKQRNENAKATYEAALKQYEADLAAVKKANAANEADYQAKLTAYQTELARVQKANADAKAAYEAAVAANNAANAALTAENTAIKKRNADAKADYEAKLAKYQADLAKYQKDLADYPVKLKAYEDEQASIKAALAELEKHKNEDGNLTEPSAQNLVYDLEPNANLSLTTDGKFLKASAVDDAFSKSTSKAKYDQKILQLDDLDITNLEQSNDVASSMELYGNFGDKAGWSTTVSNNSQVKWGSVLLERGQSATATYTNLQNSYYNGKKISKIVYKYTVDPKSKFQGQKVWLGIFTDPTLGVFASAYTGQVEKNTSIFIKNEFTFYDEDGKPINFDNALLSVASLNRENNSIEMAKDYTGKFVKISGSSIGEKNGMIYATDTLNFRQGQGGARWTMYTRASEPGSGWDSSDAPNSWYGAGAIRMSGPNNSVTLGAISSTLVVPADPTMAIETGKKPNIWYSLNGKIRAVNVPKVTKEKPTPPVKPTAPTKPTYETEKPLKPAPVAPNYEKEPTPPTRTPDQAEPNKPTPPTYETEKPLEPAPVEPSYEAEPTPPTRTPDQAEPNKPTPPTYETEKPLEPAPVEPSYEAEPTPPTPTPDQPEPNKPVEPTYEVIPTPPTDPVYQDLPTPPSVPTVHFHYFKLAVQPQVNKEIRNNNDINIDRTLVAKQSVVKFQLKTADLPAGRDETTSFVLVDPLPSGYQFNPEATKAASPGFDVTYDNATNTVTFKATAATLATFNADLTKSVATIYPTVVGQVLNDGATYKNNFTLTVNDAYGIKSNVVRVTTPGKPNDPDNPNNNYIKPTKVNKNENGVVIDGKTVLAGSTNYYELTWDLDQYKNDRSSADTIQKGFYYVDDYPEEALELRQDLVKITDANGNEVTGVSVDNYTNLEAAPQEIRDVLSKAGIRPKGAFQIFRADNPREFYDTYVKTGIDLKIVSPMVVKKQMGQTGGSYENQAYQIDFGNGYASNIIINNVPKINPKKDVTLTLDPADTNNVDGQTIPLNTVFNYRLIGGIIPADHSEELFEYNFYDDYDQTGDHYTGQYKVFAKVDITFKDGSIIKSGAELTQYTTAEVDTAKGAITIKFKEAFLRSVSIDSAFQAESYIQMKRIAVGTFENTYINTVNGVTYSSNTVKTTTPEDPTDPTDPQDPSSPRTSTVINYKPQSTAYQPSSVQETLPNTGVTNNAYMPLLGIIGLVTSFSLLGLKAKKD","574002","For other 'spa' genes see SMu0601 (spaR) and SMu0602 (spaK).From Genbank:[gi:134784]This surface protein antigen is implicated in dental caries From Genbank:[gi:482661]The saliva-interacting protein precursor probably plays a role in adherence to the tooth surface.Note tandem repeats at 571906,572189. ","cell surface antigen","Extracellular, Periplasm, Cellwall","Matches in gapped BLAST to cell surface antigen I/II, SpaP protein precursor, pac protein precursor; saliva-interacting protein from a previously published sequence (gi134784, gi129552, gi482661). Residues 1-1562 are 58% similar to cell surface antigen SpaA precursor from S.sobrinus (gi98002). Residues 4-1486 are 46% similar to salivary agglutinin receptor precursor from S.sanguis (gi97885). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1283 (2e-93).","

InterPro
IPR001899
Domain

Surface protein from Gram-positive cocci, anchor region
PF00746	$\"[1521-1560]T$	Gram_pos_anchor
TIGR01167	$\"[1528-1562]T$	LPXTG_anchor
PS50847	$\"[1529-1562]T$	GRAM_POS_ANCHORING

InterPro
IPR004829
Domain

Cell surface antigen
PD153432	$\"[846-875]T$ $\"[894-986]T$	Csurface_antigen

InterPro
IPR008988
Domain

Transcriptional repressor, C-terminal
SSF50037	$\"[1201-1297]T$	Transcr_rep_C

InterPro
IPR009578
Repeat

Streptococcal surface antigen
PF06696	$\"[201-225]T$ $\"[226-250]T$ $\"[283-307]T$ $\"[308-332]T$ $\"[365-389]T$ $\"[390-414]T$ $\"[447-471]T$	Strep_SA_rep

InterPro
IPR013574
Domain

Glucan-binding protein C
PF08363	$\"[492-816]T$	GbpC

noIPR
unintegrated

unintegrated
PR01217	$\"[832-844]T$ $\"[847-868]T$ $\"[876-892]T$ $\"[894-911]T$ $\"[925-950]T$	PRICHEXTENSN
SSF74914	$\"[464-836]T$	SSF74914

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 846-874 are identical to a (SIGNAL PRECURSOR ANTIGEN REPEAT CELL TRANSMEMBRANE) protein domain (PD153432) which is seen in Q07270_STRMU.Residues 438-476 are 57% similar to a (SUBSTANCE ANTIGEN PRECURSOR SIGNAL) protein domain (PD404193) which is seen in Q9LBG3_BBBBB.Residues 975-1157 are 78% similar to a (ANTIGEN CELL PRECURSOR SIGNAL) protein domain (PD007492) which is seen in O05158_STRMU.Residues 477-594 are 68% similar to a (ANTIGEN SIGNAL CELL PRECURSOR) protein domain (PD150368) which is seen in Q55308_BBBBB.Residues 846-873 are identical to a (SIGNAL ANTIGEN PRECURSOR REPEAT) protein domain (PD382761) which is seen in O05158_STRMU.Residues 773-823 are 64% similar to a (ANTIGEN PRECURSOR SIGNAL CELL) protein domain (PD336666) which is seen in Q53414_BBBBB.Residues 238-461 are 35% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in SSP5_STRGN.Residues 438-470 are identical to a (CELL ANTIGEN PRECURSOR SIGNAL) protein domain (PD004340) which is seen in O05158_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 12:56:04 2007","Tue Mar 6 15:00:18 2007","Tue Mar 6 15:00:18 2007","Mon Dec 10 12:48:22 2001","","Mon Dec 10 12:48:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0556 is paralogously related (blast p-value < 1e-3) to SMu1273,a predicted glucan-binding protein C, SMu1375,a predicted chromosome condensation and segregation SMC protein, SMu0018,a predicted immunodominant glycoprotein IDG-60; general stress protein GSP-781; glucan binding protein B, SMu0999,a predicted saliva-interacting protein precursor, and SMu1104, a predicted hypotheical protein.","Wed Jan 16 14:19:13 2002","","No significant hits to the NCBI PDB database.","SMU.610","","Residues 201 to 225 (E-value = 3.7e-09) place SMu0556 in the Strep_SA_rep family which is described as Streptococcal surface antigen repeat (PF06696)Residues 226 to 250 (E-value = 6.4e-06) place SMu0556 in the Strep_SA_rep family which is described as Streptococcal surface antigen repeat (PF06696)Residues 283 to 307 (E-value = 6.5e-09) place SMu0556 in the Strep_SA_rep family which is described as Streptococcal surface antigen repeat (PF06696)Residues 308 to 332 (E-value = 1.5e-08) place SMu0556 in the Strep_SA_rep family which is described as Streptococcal surface antigen repeat (PF06696)Residues 365 to 389 (E-value = 1.5e-08) place SMu0556 in the Strep_SA_rep family which is described as Streptococcal surface antigen repeat (PF06696)Residues 390 to 414 (E-value = 1.5e-08) place SMu0556 in the Strep_SA_rep family which is described as Streptococcal surface antigen repeat (PF06696)Residues 447 to 471 (E-value = 8e-09) place SMu0556 in the Strep_SA_rep family which is described as Streptococcal surface antigen repeat (PF06696)Residues 1521 to 1560 (E-value = 8.8e-08) place SMu0556 in the Gram_pos_anchor family which is described as Gram positive anchor (PF00746)","Tue Mar 6 15:00:18 2007","24379087","","Demuth DR, Irvine DC.Structural and Functional Variation within the Alanine-Rich Repetitive Domain of Streptococcal Antigen I/II.Infect Immun. 2002 Nov;70(11):6389-98.PMID: 12379719Troffer-Charlier N, Ogier J, Moras D, Cavarelli J. Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site.J Mol Biol. 2002 Apr 19;318(1):179-88.PMID: 12054777Beg A, Jones M, Miller-Torbert T, Holt R.Binding of Streptococcus mutans to extracellular matrix molecules and fibrinogen.Biochem Biophys Res Commun. 2002 Oct 18;298(1):75.PMID: 12379222Nomura Y, Eto A, Hanada N, Senpuku H. Identification of the peptide motifs that interact with HLA-DR8 (DRB1*0802) in Streptococcus mutans proteins.Oral Microbiol Immunol. 2002 Aug;17(4):209-14.PMID: 12121470Kelly,C., Evans,P., Bergmeier,L., Lee,S.F., Progulske-Fox,A.,Harris,A.C., Aitken,A., Bleiweis,A.S. and Lehner,T.Sequence analysis of the cloned streptococcal cell surface antigenI/IIFEBS Lett. 258 (1), 127-132 (1989)PubMed: 2687020Kelly,C., Evans,P., Ma,J.K., Bergmeier,L.A., Taylor,W., Brady,L.J.,Lee,S.F., Bleiweis,A.S. and Lehner,T.Sequencing and characterization of the 185 kDa cell surface antigen of Streptococcus mutansArch. Oral Biol. 35 Suppl, 33S-38S (1990)PubMed: 1982405Ma,J.K., Kelly,C.G., Munro,G., Whiley,R.A. and Lehner,T.Conservation of the gene encoding streptococcal antigen I/II inoral streptococciInfect. Immun. 59 (8), 2686-2694 (1991)PubMed: 1855988Okahashi,N., Sasakawa,C., Yoshikawa,M., Hamada,S. and Koga,T.Molecular characterization of a surface protein antigen gene fromserotype c Streptococcus mutans, implicated in dental cariesMol. Microbiol. 3 (5), 673-678 (1989)PubMed: 2761390Ogier,J.A., Wachsmann,D., Scholler,M., Lepoivre,Y. and Klein,J.P.Molecular characterization of the gene sr of the saliva interacting protein from Streptococcus mutans OMZ175Archives of oral biology. 35 Suppl, 25S-31S (1990)PubMed: 2088234Ogier,J.A., Scholler,M., Leproivre,Y., Pini,A., Sommer,P. andKlein,J.P.Complete nucleotide sequence of the sr gene from Streptococcusmutans OMZ 175FEMS Microbiol. Lett. 68, 223-228 (1990)Murakami,Y., Nakano,Y., Yamashita,Y. and Koga,T.Identification of a frameshift mutation resulting in prematuretermination and loss of cell wall anchoring of the PAc antigen ofStreptococcus mutans GS-5Infect. Immun. 65 (2), 794-797 (1997)PubMed: 9009344Sato Y, Yamamoto Y, Kizaki HCloning and sequence analysis of the gbpC gene encoding a novel glucan-binding protein of Streptococcus mutans.Infect Immun 1997 Feb;65(2):668-75PubMed: 9009329PMID: 9009329","Lamont RJ, El-Sabaeny A, Park Y, Cook GS, Costerton JW, Demuth DR. Role of the Streptococcus gordonii SspB protein in the development of Porphyromonas gingivalis biofilms on streptococcal substrates.Microbiology. 2002 Jun;148(Pt 6):1627-36.PMID: 12055284Brooks,W. and Burnie,J.P.Cloning and sequencing the endocarditis immunodominant antigen ofStreptococcus sobrinus strain MUCOB 263J. Med. Microbiol. 40 (5), 330-337 (1994)PubMed: 8176720Nakano K, Tsuji M, Nishimura K, Nomura R, Ooshima T.Contribution of cell surface protein antigen PAc of Streptococcus mutans to bacteremia.Microbes Infect. 2006 Jan;8(1):114-21.PMID: 16442486","Fri Oct 25 14:41:09 2002","Tue Apr 24 12:56:04 2007","1","","","SMU.610","" "SMu0557","574295","575848","1554","TTGAAATTTACAGAATTACATTTGGCGGAAGACATTCTTTCTGCTGTTGCAAAAGTCGGCTTTGTTGAGCCATCACCTATCCAAGAATTGACTATTCCTCTTGCCCTTGAAGGAAAAGATGTTATTGGTCAAGCACAAACTGGGACAGGAAAAACAGCAGCCTTTGGTCTGCCAACCCTGAATAAGATTGACGTGACTAATAACGTTGTTCAAGCCCTTGTTATTGCGCCAACGCGAGAATTGGCTGTTCAAAGTCAAGAGGAGCTCTTTCGTTTTGGGCGTGAAAAGAAAGTTAAAGTTCGTTCGGTTTATGGTGGTTCAAGCATTGAAAAACAAATTAAGGCTCTTAAATCAGGAGCCCATATTGTTGTTGGGACACCGGGACGTCTGCTTGATTTGATTAAACGCAAGGCGCTTAAATTAAATCATGTGGAAACCCTTATTTTGGATGAAGCAGATGAAATGCTCAACATGGGCTTTTTAGAAGATATTGAAGCCATTATTTCACGTGTACCAGAAACACGCCAAACCTTGCTCTTTTCAGCAACCATGCCAGATGCCATCAAACGTATTGGCGTAAAGTTCATGAAAGAACCAGAACATGTTAAGATTGCTGCCAAAGAATTAACAACAGATTTGGTGGATCAATATTATATCCGTGTCAAGGAAAATGAAAAATTTGATACGATGACCCGTCTTATGGATGTGGAACAGCCAGAACTTTCTATCGTTTTTGGCCGTACTAAGCGCCGTGTTGATGAGTTAACAAGAGGATTAAAACTGCGTGGCTATCGTGCGGAAGGGATTCATGGGGATCTCGATCAAGGGAAACGTCTGCGTGTTCTTCGGGATTTTAAAAATGATAACCTTGACATTTTGGTCGCGACAGATGTGGCGGCTCGTGGTCTCGATATTTCGGGCGTCACTCATGTTTATAACTATGATATTCCGCAAGACCCTGAAAGTTATGTTCATCGCATTGGTCGTACAGGTCGTGCTGGTAAGCACGGTCAGTCAATCACTTTTGTGGCTCCCAATGAAATGGGCTATCTTCAAATTATTGAAAAGCTCACTAAAAAACGCATGAAAGGCATGAAACCCGCTACAGCGCAAGAAGCCTTTCAAGCAAGCAAAAAAGTGGCCCTCAAAAAGATTGAGCGTGACTTTGCTGATGAAAAGATTCGTTCTAATTTTGATAAGTTTACCAAAGATGCTGAAAAATTGGCTGCTGAATTTTCACCAGAAGAATTAGCACAATATATCTTGACTCTAACTGTTCAAGATCCAGAAATGCTGCCTAAGGTTGAAATTGCTCGCGAAAAACCCTTGCCATTTAAATTTGCTGGTAAAGGAAAGGGCGGCAATCGTCGTCGTGAGGATCGTCGGGGAGGTCGCGACAGTCGCCGTAATCATCGTGACGGTGGCCGTCGTGAATTTAAACGGACTTCTAACAAAAATCGCAAAGATTTTGAAAATAAGAGCAATAAACGTCCTCACCGTACTTCCAGCGAAAAGAAAAGCGGCTTTACCATTCGCAATAAAGGTGACAGATAA","10.50","25.47","58445","MKFTELHLAEDILSAVAKVGFVEPSPIQELTIPLALEGKDVIGQAQTGTGKTAAFGLPTLNKIDVTNNVVQALVIAPTRELAVQSQEELFRFGREKKVKVRSVYGGSSIEKQIKALKSGAHIVVGTPGRLLDLIKRKALKLNHVETLILDEADEMLNMGFLEDIEAIISRVPETRQTLLFSATMPDAIKRIGVKFMKEPEHVKIAAKELTTDLVDQYYIRVKENEKFDTMTRLMDVEQPELSIVFGRTKRRVDELTRGLKLRGYRAEGIHGDLDQGKRLRVLRDFKNDNLDILVATDVAARGLDISGVTHVYNYDIPQDPESYVHRIGRTGRAGKHGQSITFVAPNEMGYLQIIEKLTKKRMKGMKPATAQEAFQASKKVALKKIERDFADEKIRSNFDKFTKDAEKLAAEFSPEELAQYILTLTVQDPEMLPKVEIAREKPLPFKFAGKGKGGNRRREDRRGGRDSRRNHRDGGRREFKRTSNKNRKDFENKSNKRPHRTSSEKKSGFTIRNKGDR","575845","For other 'dea' genes see SMu1265 (deaD2).For other 'rhe' genes see SMu0415 (rheB) and SMu1265 (rheB).","ATP-dependent RNA helicase/DEAD family","Cytoplasm, Membrane","Several matches in gapped BLAST to putative ATP-dependent RNA helicase proteins: residues 1-517 are 82% similar to the enzyme in S.sobrinus (gi|16117825|) and are 84% similar to the protein from S.pyogenes (gi|15902045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0777 (0.0).","

InterPro
IPR000629
Domain

ATP-dependent helicase, DEAD-box
PS00039	$\"[148-156]T$	DEAD_ATP_HELICASE

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[258-334]T$	Helicase_C
SM00490	$\"[253-334]T$	HELICc
PS51194	$\"[213-373]T$	HELICASE_CTER

InterPro
IPR011545
Domain

DEAD/DEAH box helicase, N-terminal
PF00270	$\"[25-191]T$	DEAD

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[20-217]T$	DEXDc

InterPro
IPR014014
Domain

DEAD-box RNA helicase Q motif
PS51195	$\"[1-29]T$	Q_MOTIF

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[32-202]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-212]T$	no description
PTHR10967	$\"[3-504]T$	DEAD BOX ATP-DEPENDENT RNA HELICASE
PTHR10967:SF51	$\"[3-504]T$	ATP-DEPENDENT RNA HELICASE

","BeTs to 13 clades of COG0513COG name: Superfamily II DNA and RNA helicasesFunctional Class: L,K,JThe phylogenetic pattern of COG0513 is amTkYq-CEBRHujGPol--xNumber of proteins in this genome belonging to this COG is 3","***** IPB000629 (ATP-dependent helicase, DEAD-box) with a combined E-value of 1.9e-90. IPB000629A 20-63 IPB000629B 73-85 IPB000629C 121-132 IPB000629D 144-167 IPB000629E 296-337","Residues 301-332 are 59% similar to a (HELICASE ATP-BINDING ATP-DEPENDENT RNA DNA PROTEOME) protein domain (PD007610) which is seen in Q9FQ91_TOBAC.Residues 70-106 are 59% similar to a (HELICASE PROTEOME ATP-BINDING COMPLETE) protein domain (PD402611) which is seen in P96614_BACSU.Residues 107-153 are 85% similar to a (HELICASE ATP-BINDING RNA-BINDING ATP-DEPENDENT FACTOR) protein domain (PD000276) which is seen in Q9CIK6_LACLA.Residues 73-153 are 38% similar to a (HELICASE ATP-BINDING RNA RNA-BINDING) protein domain (PD100069) which is seen in Q9SEV8_GUITH.Residues 102-188 are 28% similar to a (HELICASE ATP-BINDING RNA ATP-DEPENDENT) protein domain (PD324530) which is seen in Q9SIB5_ARATH.Residues 301-361 are 81% similar to a (HELICASE ATP-BINDING RNA-BINDING ATP-DEPENDENT FACTOR) protein domain (PD035460) which is seen in Q9Z6C9_LACRE.Residues 112-153 are 59% similar to a (HELICASE ATP-BINDING RNA-BINDING) protein domain (PD403272) which is seen in O75619_HUMAN.Residues 6-163 are 31% similar to a (HELICASE ATP-BINDING RNA-BINDING MG308) protein domain (PD035480) which is seen in Y308_MYCPN.Residues 3-60 are 65% similar to a (HELICASE ATP-BINDING RNA-BINDING ATP-DEPENDENT COMPLETE) protein domain (PD322377) which is seen in Q9CIK6_LACLA.Residues 63-106 are 56% similar to a (ATP-BINDING AUTOAGGREGATION-MEDIATING) protein domain (PD376523) which is seen in Q9Z6C9_LACRE.Residues 155-235 are 71% similar to a (HELICASE ATP-BINDING RNA-BINDING ATP-DEPENDENT FACTOR) protein domain (PD186348) which is seen in Q9CIK6_LACLA.Residues 62-106 are 73% similar to a (HELICASE RNA-BINDING ATP-BINDING PROTEOME) protein domain (PD403797) which is seen in Q9CIK6_LACLA.Residues 243-300 are 84% similar to a (HELICASE ATP-BINDING RNA-BINDING ATP-DEPENDENT DEAD-BOX) protein domain (PD287617) which is seen in Q9CIK6_LACLA.Residues 3-55 are 49% similar to a (HELICASE ATP-BINDING RNA RNA-BINDING FACTOR INITIATION) protein domain (PD099905) which is seen in O44781_CAEEL.Residues 27-118 are 32% similar to a (HELICASE III ATP-BINDING RNA) protein domain (PD243987) which is seen in YOQ2_CAEEL.Residues 362-444 are 40% similar to a (HELICASE PROTEOME ATP-BINDING COMPLETE) protein domain (PD099865) which is seen in Q9CIK6_LACLA.Residues 243-300 are 72% similar to a (HELICASE ATP-BINDING RNA RNA-BINDING ATP-DEPENDENT) protein domain (PD000033) which is seen in Q9Z6C9_LACRE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 00:32:38 2002","Thu Oct 24 09:28:21 2002","Thu Oct 24 09:28:21 2002","Mon Dec 10 13:12:22 2001","Mon Dec 10 13:12:22 2001","Mon Dec 10 13:12:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0557 is paralogously related (blast p-value < 1e-3) to SMu0415 and SMu1265,both predicted ATP-dependent RNA helicases, SMu0734,a predicted excinuclease ABC (subunit B); helicase subunit of the DNA excision repair complex, SMu1669,a predicted ATP-dependent DNA helicase, and SMu0006,a predicted transcription-repair coupling factor.","Wed Jan 16 14:26:32 2002","Mon Dec 10 13:12:22 2001","pdb|1FUU|A Chain A, Yeast Initiation Factor 4a >gi|11513345|pdb... 269 6e-073pdb|1QDE|A Chain A, Crystal Structure Of The Atpase Domain Of T... 171 2e-043pdb|1QVA|A Chain A, Yeast Initiation Factor 4a N-Terminal Domain 166 6e-042","SMU.611","","Residues 14 to 217 (E-value = 4.3e-86) place SMu0557 in the DEAD family which is described as DEAD/DEAH box helicase (PF00270)Residues 258 to 334 (E-value = 3.9e-36) place SMu0557 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)","Mon Dec 10 13:12:22 2001","24379088","","","Toone,W.M., Rudd,K.E. and Friesen,J.D.deaD, a new Escherichia coli gene encoding a presumed ATP-dependent RNA helicase, can suppress a mutation in rpsB, the gene encoding ribosomal protein S2J. Bacteriol. 173 (11), 3291-3302 (1991)PubMed: 2045359Jones,P.G., Mitta,M., Kim,Y., Jiang,W. and Inouye,M.Cold shock induces a major ribosomal-associated protein thatunwinds double-stranded RNA in Escherichia coliProc. Natl. Acad. Sci. U.S.A. 93 (1), 76-80 (1996)PubMed: 8552679","","Mon Dec 10 14:12:12 2001","1","","","SMU.611","84" "SMu0558","576338","576616","279","ATGAACACAGTAACATTAGATTCAATGGCCTTTGATAGTTTTGAAGTGGCGGATACAGATTGTTTAGCTGCTGTAGAAGGTGAGGGTTTTGTCTCGGCTGTTGCTGAAGGATTTGTGGGAGCTTATACAGGGGCTACCGCTGCTTATAGACCTGCTACGTGGCTATGGAATATTCCGGCAGTAGGACCCTACTTAGCCTTAGGGACTGAAGCAATCGGTATCGTTTCAGGTGCCTATGCTGGTGCTAAAAATGGTTGGGGAGACGGTGGCTTCTGGTGA","3.60","-8.06","9401","MNTVTLDSMAFDSFEVADTDCLAAVEGEGFVSAVAEGFVGAYTGATAAYRPATWLWNIPAVGPYLALGTEAIGIVSGAYAGAKNGWGDGGFW","576613","","hypothetical protein","Cytoplasm, Extracellular","No significant hit to gapped BLAST.SMu0558 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[60-80]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-17]?$	signal-peptide
tmhmm	$\"[5-23]?$ $\"[27-45]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[34-54]?$ $\"[60-80]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-31]?$	signal-peptide
tmhmm	$\"[10-29]?$ $\"[44-64]?$ $\"[70-90]?$	transmembrane_regions

InterPro
IPR000305
Domain

Excinuclease ABC, C subunit, N-terminal
PF01541	$\"[251-331]T$	GIY-YIG

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[120-126]?$	N6_MTASE

InterPro
IPR007848
Domain

Methyltransferase small
PF05175	$\"[19-200]T$	MTS

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[48-190]T$	G3DSA:3.40.50.150
PTHR18895	$\"[34-240]T$	PTHR18895
PTHR18895:SF2	$\"[34-240]T$	PTHR18895:SF2
SSF53335	$\"[6-199]T$	SSF53335
SSF82771	$\"[250-322]T$	SSF82771

","BeTs to 11 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 253-324 are 58% similar to a (COMPLETE PROTEOME VNG2274C BH0048) protein domain (PD010527) which is seen in Q9CEL6_LACLA.Residues 123-230 are 58% similar to a (PROTEOME COMPLETE BH0047 XPAC-ABRB) protein domain (PD113371) which is seen in Q9CDS2_LACLA.Residues 121-245 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD415361) which is seen in Q9ZJB6_HELPJ.Residues 6-122 are 61% similar to a (PROTEOME COMPLETE BH0047 XPAC-ABRB) protein domain (PD338431) which is seen in Q9CDS2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 14:38:05 2002","Mon Dec 10 14:21:34 2001","Wed Jan 16 14:38:05 2002","Mon Dec 10 14:21:34 2001","","Mon Dec 10 14:21:34 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0563 is paralogously related (blast p-value < 1e-3) to SMu0464,a predicted conserved hypothetical and to SMu0468 a predicted type II DNA modification methyltransferase.","Wed Jan 16 14:37:32 2002","","No significant hits to the NCBI PDB database.","SMU.621c","","Residues 251 to 331 (E-value = 5.3e-21) place SMu0563 in the GIY-YIG family which is described as GIY-YIG catalytic domain (PF01541)","Mon Dec 10 14:21:34 2001","24379094","","","","","","1","","","SMU.621c","322" "SMu0564","581144","580632","513","ATGACTACTTATGTTTGGTTATTTCCTTTACTTTTTATCTTTCATGACTTAGAAGAAATCATTGGCTTCATACCTTGGATAGAGAAAAAAAGTGATCTTCTTAAGGAAAAAGCCCCTCTTCTTTTAAAGACGCATAAGGATTTGACAACAGAGGGCTTCGCTCTGGCTGTTTTTGAGGAATTCTGCTTGATTCTCCTTATCTCCCTAGCAGCTTTTTGCAGTCAAAGCCGATTTCTTTATCTGATTTGGTTAGGCGGACTAATAGCCTTTAGTTTACATTTGCTGTTTCATATCATACAAGCCTTTATGCTAAGACAGTATATCCCAGCTGTGGGAACGGCTCTTTTATGTCTGCCAATCAGCTCTGTCATTATCCTAAATAGTTGTCATTTTCTTCATGTCAATGTGATAGAATTATTCTGTTTTGGTTTGATTGGATTATTAATTGTTATCTTCAATCTCTTGCTTGCTCTCAGGCTGGGTAAGCAATTTTCTAAATGGTTGAACAGCTAA","7.40","1.19","19455","MTTYVWLFPLLFIFHDLEEIIGFIPWIEKKSDLLKEKAPLLLKTHKDLTTEGFALAVFEEFCLILLISLAAFCSQSRFLYLIWLGGLIAFSLHLLFHIIQAFMLRQYIPAVGTALLCLPISSVIILNSCHFLHVNVIELFCFGLIGLLIVIFNLLLALRLGKQFSKWLNS","580635","","conserved hypothetical protein","Membrane, Cytoplasm","Single match in gapped BLAST to a hypothetical protein. Residues 3-120 are 31% similar to a predicted membrane protein in Clostridium acetobutylicum (gi|15894009|). SMu0564 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[5-27]?$ $\"[53-73]?$ $\"[78-96]?$ $\"[106-126]?$ $\"[136-156]?$	transmembrane_regions

InterPro
IPR002509
Domain

Polysaccharide deacetylase
PF01522	$\"[102-215]T$	Polysacc_deac_1

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.370	$\"[103-310]T$	G3DSA:3.20.20.370
SSF88713	$\"[65-310]T$	SSF88713

","BeTs to 5 clades of COG0726COG name: Predicted xylanase/chitin deacetylaseFunctional Class: GThe phylogenetic pattern of COG0726 is ----Y-vcEBr-uj-------Number of proteins in this genome belonging to this COG is 2","***** IPB002509 (Polysaccharide deacetylase) with a combined E-value of 2.1e-12. IPB002509A 111-118 IPB002509B 129-141 IPB002509C 160-170 IPB002509F 273-282","Residues 109-170 are 47% similar to a (NODULATION DEACETYLASE HYDROLASE COMPLETE) protein domain (PD337503) which is seen in NODB_RHILP.Residues 107-170 are 45% similar to a (COMPLETE PROTEOME HYDROLASE XYLAN) protein domain (PD175188) which is seen in O87119_CLOTM.Residues 111-170 are 45% similar to a (HYDROLASE DEACETYLASE NODULATION COMPLETE) protein domain (PD002133) which is seen in Q9L1T3_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 16:30:50 2002","Thu Feb 22 09:37:24 2007","Thu Feb 22 09:37:24 2007","Tue Dec 11 10:46:43 2001","Tue Dec 11 10:46:43 2001","Tue Dec 11 10:46:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0565 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 11 13:05:12 2001","","No significant hits to the NCBI PDB database.","SMU.623c","","Residues 102 to 234 (E-value = 2.3e-26) place SMu0565 in the Polysacc_deac_1 family which is described as Polysaccharide deacetylase (PF01522)","Tue Dec 11 10:46:43 2001","24379096","","","","","","1","","","SMU.623c","" "SMu0566","582307","583059","753","GTGTTTTATACCTACCTGCGCTCTTTGTTAGTTTTTTTAATTTGGGCTGCTAATGGTAATATTCATTACCATCATCGAGATAAATTGTTGCCTGAAGATGACAATTATATTTTAGTTGCACCTCACCGTACACTATGGGATCCTATCTTTTTAGCTTTTGCAGCTCGGCCTAAGCAATTTATCTTTATGGCTAAGAAGGAATTATTTGGCAATCGTGCTTTCGGCTGGTGGATTCGCATGTGTGGAGCTTTTCCGATTGATCGTAAAAACCCAGGGACTGAGGCTGTCCGTTATCCTGTTAAAATGCTTAGGAAAAGCGATCGTTCTTTGATTATGTTTCCAAGTGGAAGTCGTCATTCTTCTGATGTTAAAGGTGGCGTTGCAGTTATTGCCAAAACAGCAAAAGTTAAAATTATGCCTGCAGCCTATGCGGGGCCAAGATCCATCAAAGGCTTGCTTAAACATGATCGTATTGATGTTACTTTTGGCAATCCCATTGATATTTCAGATATTAAGCGCATGAATGACGATGGCATTGAAGAAGTGGCTCATCGTATTGAAAAAGAATTTGACCAAATGGATACAGAAGTTGCAACTTTCAAAGATAATGAGCGACCAAGCTGGTGGAGCTTGATTTATCGTTTGCCAGCTATGGTTTTGGTGGCTATTGTTCTTGCTTTCACTTACCTCTTTTCTTGGTTCGCTAGTTTTGTCTGGAACCCAGAAAAGCATCGTGATAAAAAAATAAAATAA","10.50","12.88","29005","MFYTYLRSLLVFLIWAANGNIHYHHRDKLLPEDDNYILVAPHRTLWDPIFLAFAARPKQFIFMAKKELFGNRAFGWWIRMCGAFPIDRKNPGTEAVRYPVKMLRKSDRSLIMFPSGSRHSSDVKGGVAVIAKTAKVKIMPAAYAGPRSIKGLLKHDRIDVTFGNPIDISDIKRMNDDGIEEVAHRIEKEFDQMDTEVATFKDNERPSWWSLIYRLPAMVLVAIVLAFTYLFSWFASFVWNPEKHRDKKIK","583056","","1-acylglycerol-3-phosphate O-acyltransferase","Cytoplasm, Membrane, Extracellular","Matches in gapped BLAST to putative 1-acylglycerol-3-phosphate O-acyltransferase: residues 1-245 are 67% similar to the enzyme in S.pyogenes (gi15675330). Residues 1-247 are 61% similar to the protein from S.pneumoniae (gi15901460).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0780 (1e-101).","

InterPro
IPR002123
Domain

Phospholipid/glycerol acyltransferase
PF01553	$\"[20-144]T$	Acyltransferase
SM00563	$\"[36-146]T$	PlsC

noIPR
unintegrated

unintegrated
PTHR10434	$\"[30-232]T$	1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE
signalp	$\"[1-19]?$	signal-peptide
tmhmm	$\"[217-237]?$	transmembrane_regions

","BeTs to 10 clades of COG0204COG name: 1-acyl-sn-glycerol-3-phosphate acyltransferaseFunctional Class: IThe phylogenetic pattern of COG0204 is ----YQvCEbRhujgpolINXNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 63-196 are 58% similar to a (ACYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD000989) which is seen in Q9CJ88_LACLA.Residues 1-62 are 54% similar to a (PROTEOME COMPLETE YBBE) protein domain (PD388376) which is seen in Q9CJ88_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 09:24:24 2002","Wed Jan 16 16:32:10 2002","Fri Sep 8 14:33:37 2006","Tue Dec 11 13:11:45 2001","","Tue Dec 11 13:11:45 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0566 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 11 13:14:01 2001","","No significant hits to the NCBI PDB database.","SMU.624","","Residues 20 to 144 (E-value = 9.9e-25) place SMu0566 in the Acyltransferase family which is described as Acyltransferase (PF01553)","Tue Dec 11 13:11:45 2001","24379097","","","","","","1","","","SMU.624","323" "SMu0567","583200","583877","678","ATGGTTGACGAATTTTTAGATAAACTCAAGGAAAAGAAAAATGTTTTTGCCCTAGTTGGTGGTCTTGTAGTCTTACTGGGTCTGGGTGTTTATTTCTTTTTTCCTTCTTCCAATAAGCAGGAAGATAGTCTGGCTCGTTTAAAGGAACAATCCCTTCAGGTAACCACAAAGACTGGCAAAGAAAGTCAGAAGAAGACGCAGACGACTGCCAAATCAACAATAACTGTTGATATTAAAGGAGCTGTTAAGCATGAGGGCGTCTATACTTTACCGATTGACAGTCGTATTAATGATGTAATAGAAAAAGCGGGAGGTTTTTCTGAAAAGGCTGATCGCAAATCTGTTAATCTGGCTCAAAAATTACAAGACGAAGCAGTTATTTATGTGGCAGCTATTGGTGAGAATATTAGTGTCATTAGGGATTCTCAAGAAGGTAAAACCAGTCAGGCAGATAAGGCAAATACTAAAGAAACTTCGGTAAAAGGTAAGGTTAATCTTAATACTGCCACTTTGGCTGATTTACAGACTATTTCTGGAATCGGTGAGAAGAAAGCTCAGGATATTCTTGATTACCGTGAAGCCAATGGAGGTTTTAAGTCAGTGGATGATTTGAAAAATATTTCAGGGATTGGCGATAAAACATTTGAGAAGTTAAAGGATTTAGTCAGTGTTGATTAG","8.80","1.25","24445","MVDEFLDKLKEKKNVFALVGGLVVLLGLGVYFFFPSSNKQEDSLARLKEQSLQVTTKTGKESQKKTQTTAKSTITVDIKGAVKHEGVYTLPIDSRINDVIEKAGGFSEKADRKSVNLAQKLQDEAVIYVAAIGENISVIRDSQEGKTSQADKANTKETSVKGKVNLNTATLADLQTISGIGEKKAQDILDYREANGGFKSVDDLKNISGIGDKTFEKLKDLVSVD","583874","For other 'cel' genes see SMu0568 (celB).For other 'com' genes see SMu0568 (comEC); SMu0138 (comR); SMu1814 (comX1);SMu0258 (comA); SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). ","competence protein","Membrane, Periplasm, Extracellular","Several matches in gapped BLAST to competence proteins: residues 74-225 are 55% similar to the protein in S.pneumoniae (gi15674251) and are 50% similar to the protein from S.pyogenes(gi15675329).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0781 (2e-47).","

InterPro
IPR000445
Domain

Helix-hairpin-helix motif
PF00633	$\"[162-191]T$	HHH

InterPro
IPR003583
Domain

Helix-hairpin-helix DNA-binding, class 1
SM00278	$\"[172-191]T$ $\"[202-221]T$	HhH1

InterPro
IPR004509
Domain

Competence protein ComEA helix-hairpin-helix region
TIGR00426	$\"[159-224]T$	ComEA_HHH

InterPro
IPR010994
Domain

RuvA domain 2-like
SSF47781	$\"[164-218]T$	RuvA_2_like

noIPR
unintegrated

unintegrated
PTHR21180	$\"[73-224]T$	PTHR21180
PTHR21180:SF8	$\"[73-224]T$	PTHR21180:SF8

","BeTs to 5 clades of COG1555COG name: DNA uptake protein ComEA and related DNA-binding proteinsFunctional Class: LThe phylogenetic pattern of COG1555 is ------vcebrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 164-225 are 66% similar to a (PROTEOME COMPLETE COMPETENCE DNA) protein domain (PD006092) which is seen in O85197_STRPN.Residues 74-134 are 63% similar to a (COMPETENCE PROTEOME COMPLETE OPERON) protein domain (PD189516) which is seen in O85197_STRPN.Residues 166-218 are 66% similar to a (PROTEOME COMPLETE COMEA COMPETENCE) protein domain (PD285868) which is seen in Q9X0E2_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 13:30:13 2007","Thu Jan 17 16:19:00 2002","Fri Jul 7 16:33:27 2006","Tue Dec 11 13:19:41 2001","","Tue Dec 11 13:19:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0567 is paralogously related (blast p-value < 1e-3) to SMu0682, a predicted conserved hypothetical protein;a possible transcriptional accessory protein.","Thu Jan 17 16:19:00 2002","","No significant hits to the NCBI PDB database.","SMU.625","","Residues 162 to 191 (E-value = 2.7e-06) place SMu0567 in the HHH family which is described as Helix-hairpin-helix motif (PF00633)","Tue Dec 11 13:19:41 2001","24379098","","","Pestova,E.V. and Morrison,D.A.Isolation and characterization of three Streptococcus pneumoniaetransformation-specific loci by use of a lacZ reporter insertionvectorJ. Bacteriol. 180 (10), 2701-2710 (1998)PubMed: 9573156Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337","","Tue Apr 24 13:30:13 2007","1","","","SMU.625","784" "SMu0568","583867","586101","2235","GTGTTGATTAGGTTTTTTCCTCTCAAACCAATCTATTTAGCCTTTTTAACTGTTTTGCTTTATTTTTGTATTCACTGCTTTTCTTTTTTGCCAGTTGGCCTATTTATTTTAGCTTTAGTCTTTCTTGTTTTTCAATATGATAGGCAAATCTGTATCAAAACACTTTTGTTTTTATTGCCTTTTGCCGCTTTCTTTTTCTATTTTCACCAAAAAAGGCAAAGCGAGTATCAAATAGTACCCAGACAGGTTCAAAAGTTAATTATCATTCCAGATACGCTTAGTGTCAATGGAGATAACTTAAGTTTTCGAGCAAAATCAGGTCATTGGACTTATCAGGTCTTTTATAAATTAAAATCTGAAACAGAGAAACATTATTTTGAACAATTATGGCAGACAGCAGAAATTCAAGTGACAGCAGATGTTGTAGAAGCAGAAGAGCAGCGTAATTTCAAGGGATTCGATTATAGAAACTATTTAAAGATGCAGGGAATTTACCGAATTGTTAATGTTACAGACATTAAAACAATTAAACTGAGTTCTAAACGCTTCTGGTTTGCTCGTTTGCATGAATGGCGACGAAGAGCTTTGGTATCTATTCAGTCAAAATTTCCAGACCCCATGAAACACTATATGACTGGTCTGCTTTTTGGCTATTTAGATAAATCCTTTGATGAAATGAATGCTATTTATTCTAGCTTAGGTATTATTCACCTTTTTGCTTTGTCAGGTATGCAGGTTAGTTTTTTCATTGGGAAATTTCGTTATTTGGGCTTGCGTTTAGGTATTAGACAGGAATACATGAATGCTATTCAGCTGCCCTTTTCTTTGCTTTATGCTGGTTTGACTGGCTTTGCAGTATCCGTTGTGCGTAGTTTGATTCAAGGTAATCTTACTCATTTTGGTTTTAAAAAGCAGGATAACTTTGCTCTAACCTTATTTGTTATGTTTTTCCTGATACCCAATTTCTTATTAACAACAGGAGGTGTGCTTAGTTTTGCCTATGCTTTTATTCTAATCATGATTGATTTTGAGACTTTGTCACTCTTAAAGCGGATTCTATTTCAAACCTTTTCTCTTTCTTTAGGGATTTTACCGTTATTGATGTGGTATTTTAGCAGTTTTCAGCCCTTGTCTATCCTATTAACTATCCTCTTTTCTTTTATTTTTGATAACTTGATGTTGCCTTTTTTGACACTTGCTTATTTTCTGTCACCTTTTGTATCACTTGCCTGCTTCAATCCAGCTTTTAGATTATTAGAAAGAATAATTGTTCAAATTCACCTAATCTTTAGTCGTCCTTTTATTTTGGGCAGTCCGACTTTGCCTATTCTCTTACTTTTATTGTGCCTTTTAGCTTTACTCTATGATTTTCGTCAGAAAAAAAGGGTAGTGTTAGTACTTAGTAGCATTCTCGCCCTGTTATTTTTCATCAGTAAAAATCCTTTGACTAATGAAGTGACTATTGTTGATATTGGTCAGGGGGATAGTATTCTTCTTCGGGATATCAGCAGTAAGACTATTTTAATTGATGTAGGAGGAAAAGTAACTTTTGGACAGACTGATAAATGGCGGCGGCGTATCAGTGATACTAATGCTGAAAAGACTTTGATTCCCTATCTCAAAAGCAGAGGCATTGATAAGATTGACCAATTGGTTTTGACTCATACTGACACGGATCATATGGGAGATATGGAAGTGGTGGCAAAGGCCTTTCATGTTGGGGAAGTTTTAGTTAGTCCAGGCAGTTTAACTAAGGCAAATTTTGTCAGTAAATTGAGAAGAATGAAAGTTAAGGTACACATCACTAAGCCAGGGGAGACATTATCCATTATGGGGAGTCATTTACAGGTACTCTATCCGTTGAAAATAGGTGATGGTGGTAATAATGACTCTATCGTTCTTTATGGACGTTTGCTAGGCTTAAATTTTCTCTTTACAGGAGATTTGGAAAAAGAAGGAGAAGCAGAATTGCTAAAGACTTATCCCAATTTAAAAGTTGATGTCTTAAAAGCTGGACATCATGGTTCAAAAGGTTCTTCTTCACCTGAATTATTAGCTCAAATAGAGCCTAAAATTGCTCTTATCTCGGCAGGAAAGAACAATCGTTATAAACATCCCCATCAGGAGACACTGGACAGATTTGCGCAAATAAAAAGTCGGATTTATCGGACGGATCAAGAGGGTGCCATTCGTTTTAAGGGTCTTAAGCATTGGCAGATTGAGACTGTGCGATAA","10.40","31.36","85507","MLIRFFPLKPIYLAFLTVLLYFCIHCFSFLPVGLFILALVFLVFQYDRQICIKTLLFLLPFAAFFFYFHQKRQSEYQIVPRQVQKLIIIPDTLSVNGDNLSFRAKSGHWTYQVFYKLKSETEKHYFEQLWQTAEIQVTADVVEAEEQRNFKGFDYRNYLKMQGIYRIVNVTDIKTIKLSSKRFWFARLHEWRRRALVSIQSKFPDPMKHYMTGLLFGYLDKSFDEMNAIYSSLGIIHLFALSGMQVSFFIGKFRYLGLRLGIRQEYMNAIQLPFSLLYAGLTGFAVSVVRSLIQGNLTHFGFKKQDNFALTLFVMFFLIPNFLLTTGGVLSFAYAFILIMIDFETLSLLKRILFQTFSLSLGILPLLMWYFSSFQPLSILLTILFSFIFDNLMLPFLTLAYFLSPFVSLACFNPAFRLLERIIVQIHLIFSRPFILGSPTLPILLLLLCLLALLYDFRQKKRVVLVLSSILALLFFISKNPLTNEVTIVDIGQGDSILLRDISSKTILIDVGGKVTFGQTDKWRRRISDTNAEKTLIPYLKSRGIDKIDQLVLTHTDTDHMGDMEVVAKAFHVGEVLVSPGSLTKANFVSKLRRMKVKVHITKPGETLSIMGSHLQVLYPLKIGDGGNNDSIVLYGRLLGLNFLFTGDLEKEGEAELLKTYPNLKVDVLKAGHHGSKGSSSPELLAQIEPKIALISAGKNNRYKHPHQETLDRFAQIKSRIYRTDQEGAIRFKGLKHWQIETVR","586098","For other 'cel' genes see SMu0567 (celA).For other 'com' genes see SMu0567 (comEA); SMu0138 (comR); SMu1814 (comX1);SMu0258 (comA); SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). ","competence protein; possible integral membrane protein","Membrane, Cytoplasm","Several matches in gapped BLAST to competence proteins:residues 4-744 are 46% similar to the enzyme in S.pyogenes (gi13622508). Residues 3-744 are 46% similar to the protein from S.pneumoniae (gi15900832).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0782 (0.0).","

InterPro
IPR001279
Domain

Beta-lactamase-like
PF00753	$\"[493-699]T$	Lactamase_B

InterPro
IPR004477
Domain

ComEC/Rec2-related protein
PF03772	$\"[214-460]T$	Competence
TIGR00360	$\"[235-396]T$	ComEC_N-term: ComEC/Rec2-related protein

InterPro
IPR004797
Family

DNA internalization-related competence protein ComEC/Rec2
TIGR00361	$\"[69-728]T$	ComEC_Rec2: DNA internalization-related com

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[365-497]T$	no description

noIPR
unintegrated

unintegrated
signalp	$\"[1-45]?$	signal-peptide
tmhmm	$\"[10-44]?$ $\"[50-68]?$ $\"[229-249]?$ $\"[275-293]?$ $\"[308-323]?$ $\"[329-349]?$ $\"[369-389]?$ $\"[395-415]?$ $\"[435-455]?$	transmembrane_regions

","BeTs to 8 clades of COG0658COG name: Uncharacterized BCR, ComEC familyFunctional Class: SThe phylogenetic pattern of COG0658 is -----qvcebrhujgpolin-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 207-373 are 30% similar to a (MG316 TRANSMEMBRANE H08_ORF369 HOMOLOG) protein domain (PD040333) which is seen in Y316_MYCGE.Residues 262-439 are 43% similar to a (COMPETENCE PROTEOME COMPLETE COME) protein domain (PD128123) which is seen in O85198_STRPN.Residues 626-731 are 55% similar to a (COMPLETE PROTEOME COMPETENCE) protein domain (PD017552) which is seen in Q9CER4_LACLA.Residues 143-261 are 56% similar to a (PROTEOME COMPLETE COMPETENCE) protein domain (PD006990) which is seen in O85198_STRPN.Residues 11-129 are 35% similar to a (COMPETENCE PROTEOME COMPLETE COMEC) protein domain (PD183539) which is seen in O85198_STRPN.Residues 479-579 are 58% similar to a (COMPETENCE COMPLETE PROTEOME) protein domain (PD414978) which is seen in O85198_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 09:08:59 2006","Thu Jan 17 16:20:29 2002","Tue Aug 1 09:08:59 2006","Tue Dec 11 13:25:49 2001","","Tue Dec 11 13:25:49 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0568 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 11 14:11:08 2001","","No significant hits to the NCBI PDB database.","SMU.626","","Residues 214 to 460 (E-value = 8.5e-44) place SMu0568 in the Competence family which is described as Competence protein (PF03772)Residues 493 to 699 (E-value = 1.1e-11) place SMu0568 in the Lactamase_B family which is described as Metallo-beta-lactamase superfamily (PF00753)","Tue Aug 1 09:08:59 2006","24379099","","","Pestova,E.V. and Morrison,D.A.Isolation and characterization of three Streptococcus pneumoniaetransformation-specific loci by use of a lacZ reporter insertionvectorJ. Bacteriol. 180 (10), 2701-2710 (1998)PubMed: 9573156","","Tue Dec 11 14:14:43 2001","1","","","SMU.626","85" "SMu0569","586287","586913","627","ATGTTTACAGCTTATAAAAAATTCTGGACAAACTATGTTAATTTTACAGGTCGTTCAAGTCGTTCAGATTATTGGTGGGCAATCTTGTGCAATTCTTTAATTATATTGCCATTTGTTTTTACGGCTACCTCAATTTTCTATTCCAATTTAATTGAATTTATTAGGGGTTCTGCTATTTCTACTTTTTCTGGTGAAGAGTCAGTTTTGTCTGTTTACTCAATAGATGTTATTATTCTCTTTATTATTATTGTCCTTTTTTCATTGGCTATTTTATTACCTAATTTAGCTATTTCTATTCGTCGTTTACGCGATGCCGGTTTTCATTGGTCCTTAATTTTTGTTCCGATAGGAGCAGCTTTATTTTCATTCTTAGGACTGATTCCATTTTTACGTGCAATTGTATCTATCATAGTTTGGTTTGCATTGATCTTTTATTACATCCTGCTTTGCCAACCAAGTAAACCTTATCAGGCGCCTGTACAACCAATTGCTCCTCAGCAGCCTCAGCAAATGGCTCCACAAGGACAGCCAGTTCAGGCTCAGGTACAACCACAGTCACAGACAACTCCTCAACAGCCGCAAACTCCACCAGTGCAACAACCACAAGCACCTACTAATCAACAATAA","9.90","4.12","23489","MFTAYKKFWTNYVNFTGRSSRSDYWWAILCNSLIILPFVFTATSIFYSNLIEFIRGSAISTFSGEESVLSVYSIDVIILFIIIVLFSLAILLPNLAISIRRLRDAGFHWSLIFVPIGAALFSFLGLIPFLRAIVSIIVWFALIFYYILLCQPSKPYQAPVQPIAPQQPQQMAPQGQPVQAQVQPQSQTTPQQPQTPPVQQPQAPTNQQ","586910","","conserved hypothetical protein","Membrane, Periplasm, Cytoplasm","Limited matches in gapped BLAST to unknown proteins:residues 4-137 are 29% similar to Listeria innocua (gi|16799755|) and 29% similar to Listeria monocytogenes (gi|16802714|).SMu0569 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR008523
Family

Protein of unknown function DUF805
PF05656	$\"[11-164]T$	DUF805

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-108 are 33% similar to a (PROTEOME COMPLETE EXUR-TDCC YIIG) protein domain (PD031314) which is seen in Q9ZI22_STRSL.Residues 1-154 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD399440) which is seen in Q9CG10_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 16:21:17 2002","Tue Dec 11 14:34:38 2001","Thu Jan 17 16:21:17 2002","Tue Dec 11 14:34:38 2001","","Tue Dec 11 14:34:38 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0569 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 11 14:39:33 2001","","No significant hits to the NCBI PDB database.","SMU.627","","Residues 11 to 164 (E-value = 1.2e-20) place SMu0569 in the DUF805 family which is described as Protein of unknown function (DUF805) (PF05656)","Tue Dec 11 14:34:38 2001","24379100","","","","","","1","","","SMU.627","" "SMu0570","587081","588121","1041","ATGATTGCTATAGAAATGATTGAAAAGTTAAAAAAAGAGGAACTTGCATCCATTACTGTTTTAAGTGGAGAAGATTTTGGCCAATATGGGCAAATGAAAAAACTCTTTTTTAATAAAATTGGCTTTGAATCGAGTGATTTGAATTTTTCTTATTTTGATATGTCTGAAACGTCTTATCAGGATGCAGAAATGGATTTAGAAAGTTTACCTTTTTTTGCTGATGAGAAGATTGTTATTTTTGATAATTTTGCAGACATCACAACGGATAAAAAAACTTTTTTAAATAATAACGAATTGAAGCGTTTTGAGGCCTATTTAGGAAATCCTCTTTCCAGTACAAAATTAGTTATTTGTGCTTCTGGGAAATTAGATGGTAAACGTCGTTTAGTTAAATTGTTAAAACGAGATGCTCAGCTTTTCGAAGCGAAAGTGCTCAAAGAAGCAGAGCTTCGTACTTATTTTCAAAAGCGGGCACACAAGGATGGTCTTGTTTTTGAATCAGGTGTATTTGAAAGTTTGTTGATAAAGTCTAACTTTGATTTTAGTGAAGTTGCTAAAAATCTTACTTTCCTGACTTCCTATAAAAAGGATGGACATATTAGGGCTCAAGACATCAGTGAGGCTATTCCCAAGACTTTACAGGATAATATTTTTGATTTAACACAATTTATTTTGACAGGACAGATTGATGCAGCGCGTGATTTAATCCGTGATTTGCGTCTTCAGGGAGAAGATGAGATTAAGTTAATTGCAGTCATGTTGGGGCAATTCCGCATGTTCACTCAGATAAAAATTTTAAGTGGCCAAAATAAATCTGAGACTCAAATAGTGACAGCTTTATCAGACTATTTAGGGCGAAAAGTTAATCCCTATCAGGTTAAATTTGCTTTACGTGATTCAAGAACACTCACTTTACCTTTTTTGAAAAAGGCTGTGACGTTGTTAATTGAAACAGATTATGCTATTAAGAGCGGGACTTACGATAAGGACTATCTTTTTGATGTAGCTTTGCTTAAATTAGCTCATGAAAATCGGGGATGA","6.40","-1.30","39596","MIAIEMIEKLKKEELASITVLSGEDFGQYGQMKKLFFNKIGFESSDLNFSYFDMSETSYQDAEMDLESLPFFADEKIVIFDNFADITTDKKTFLNNNELKRFEAYLGNPLSSTKLVICASGKLDGKRRLVKLLKRDAQLFEAKVLKEAELRTYFQKRAHKDGLVFESGVFESLLIKSNFDFSEVAKNLTFLTSYKKDGHIRAQDISEAIPKTLQDNIFDLTQFILTGQIDAARDLIRDLRLQGEDEIKLIAVMLGQFRMFTQIKILSGQNKSETQIVTALSDYLGRKVNPYQVKFALRDSRTLTLPFLKKAVTLLIETDYAIKSGTYDKDYLFDVALLKLAHENRG","588118","","DNA polymerase III, delta subunit","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 18-343 are 69% similar to S.agalactiae gi2765186 and residues 17-343 are 62% similar to S.pneumoniae (gi15900659).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0787 (1e-135).","

InterPro
IPR005790
Family

DNA polymerase III, delta subunit
TIGR01128	$\"[15-341]T$	holA

InterPro
IPR008921
Domain

DNA polymerase III clamp loader subunit, C-terminal
SSF48019	$\"[215-346]T$	Pol_clamp_load_C

InterPro
IPR010372
Family

DNA polymerase III, delta
PF06144	$\"[19-338]T$	DNA_pol3_delta

noIPR
unintegrated

unintegrated
SSF52540	$\"[1-214]T$	SSF52540

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 207-325 are 30% similar to a (PROTEOME COMPLETE) protein domain (PD320209) which is seen in Q55399_SYNY3.Residues 123-329 are 71% similar to a (PROTEOME YRAC COMPLETE AQ_1104) protein domain (PD134921) which is seen in O54085_STRAG.Residues 18-119 are 63% similar to a (PROTEOME COMPLETE YRAC COMEC-RPST) protein domain (PD024574) which is seen in O54085_STRAG.Residues 123-340 are 28% similar to a (PROTEOME COMPLETE DNA-BINDING BH1337) protein domain (PD333149) which is seen in Q9KD80_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 09:28:08 2002","Mon Sep 11 10:20:41 2006","Mon Sep 11 10:20:41 2006","Tue Dec 11 14:43:46 2001","","Tue Dec 11 14:43:46 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0570 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 11 14:44:15 2001","","No significant hits to the NCBI PDB database.","SMU.628","","No significant hits to the Pfam 11.0 database","Tue Dec 11 14:43:46 2001","24379101","","","","","","1","","","SMU.628","324" "SMu0571","588268","588879","612","ATGGCTATTCTTTTACCAGATCTTCCATATGCTTATGACGCACTTGAACCATATATTGATGCTGAAACGATGACCCTTCATCATGATAAGCATCATGCAACTTATGTCGCAAACGCTAATGCGGCTCTTGAAAAACATCCAGAAATCGGAGAAAATTTGGAAGTGCTTTTGGCTGATGTGGAACAAATTCCAGCGGATATTCGTCAGTCTTTGATTAATAATGGTGGCGGTCATCTTAATCACGCTCTTTTCTGGGAACTCTTGTCACCAGAAAAGACAAAAGTTACTGCGGAAGTAGCCGCAGCAATTAATGAAGCTTTTGGCTCATTTGATGATTTTAAAGCAGCTTTTACAGCTGCCGCAACGACGCGTTTTGGCTCAGGTTGGGCTTGGTTAGTAGTTGATAAAGAAGGAAAACTTGAAGTGACCTCAACAGCTAATCAAGATACTCCAATTTCACAGGGCTTGAAACCAATTCTAGCACTTGATGTCTGGGAACACGCTTATTATCTCAATTATCGTAATGTTCGTCCAAACTATATCAAAGCCTTCTTTGAAGTTATCAATTGGAACACTGTTGCTCGTCTTTATGCCGAAGCTCTCACTAAATAA","4.90","-10.07","22610","MAILLPDLPYAYDALEPYIDAETMTLHHDKHHATYVANANAALEKHPEIGENLEVLLADVEQIPADIRQSLINNGGGHLNHALFWELLSPEKTKVTAEVAAAINEAFGSFDDFKAAFTAAATTRFGSGWAWLVVDKEGKLEVTSTANQDTPISQGLKPILALDVWEHAYYLNYRNVRPNYIKAFFEVINWNTVARLYAEALTK","588876","This enzyme destroys radicals which are normally produced within the cells and are toxic to biological systems [gi:2507403].","superoxide dismutase","Extracellular, Cytoplasm","Matches in gapped BLAST to superoxide dismutase:residues 1-203 are 93% similar to the previously published enzyme in S.mutans (gi|2507403|).Residues 1-200 are 78% similar to the enzyme from S.pyogenes (gi|15675326|) and are 76% similar to the enzyme from S.agalactiae (gi|2765187|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0788 (1e-90).","

InterPro
IPR001189
Family

Manganese and iron superoxide dismutase
PD000475	$\"[96-203]T$	SODismutase
PR01703	$\"[6-17]T$ $\"[27-40]T$ $\"[72-85]T$ $\"[124-132]T$ $\"[161-173]T$	MNSODISMTASE
PTHR11404	$\"[1-201]T$	SODismutase
PF00081	$\"[2-89]T$	Sod_Fe_N
PF02777	$\"[96-197]T$	Sod_Fe_C
PS00088	$\"[163-170]T$	SOD_MN
SSF46609	$\"[1-90]T$	SODismutase
SSF54719	$\"[90-200]T$	SODismutase

noIPR
unintegrated

unintegrated
PTHR11404:SF9	$\"[1-201]T$	PTHR11404:SF9

","BeTs to 11 clades of COG0605COG name: Superoxide dismutaseFunctional Class: PThe phylogenetic pattern of COG0605 is --t-Yq-cEBrhuj--o-inxNumber of proteins in this genome belonging to this COG is 1","***** IPB001189 (Manganese and iron superoxide dismutase (SODM)) with a combined E-value of 2.1e-92. IPB001189A 5-40 IPB001189B 74-90 IPB001189C 95-132 IPB001189D 158-190","Residues 5-200 are 92% similar to a (DISMUTASE SUPEROXIDE OXIDOREDUCTASE MANGANESE MN IRON) protein domain (PD000475) which is seen in SODM_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 16:24:12 2002","Tue Dec 11 14:54:01 2001","Sun Nov 10 16:00:42 2002","Tue Dec 11 14:45:30 2001","Tue Dec 11 14:45:30 2001","Tue Dec 11 14:45:30 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0571 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 11 14:45:44 2001","Tue Dec 11 14:45:30 2001","pdb|1MNG|A Chain A, Manganese Superoxide Dismutase (E.C.1.15.1.... 217 9e-058pdb|1D5N|A Chain A, Crystal Structure Of E. Coli Mnsod At 100k ... 199 2e-052pdb|1VAR|A Chain A, Mitochondrial Manganese Superoxide Dismutas... 166 2e-042","SMU.629","","Residues 2 to 89 (E-value = 3.2e-42) place SMu0571 in the Sod_Fe_N family which is described as Iron/manganese superoxide dismutases, alpha-hairpin domain (PF00081)Residues 96 to 197 (E-value = 5e-61) place SMu0571 in the Sod_Fe_C family which is described as Iron/manganese superoxide dismutases, C-terminal domain (PF02777)","Tue Dec 11 14:45:30 2001","24379102",""," Abranches J, Lemos JA, Burne RA.,Osmotic stress responses of Streptococcus mutans UA159.FEMS Microbiol Lett. 2006 Feb;255(2):240-6.PMID: 16448501Nakayama,K.Nucleotide sequence of Streptococcus mutans superoxide dismutasegene and isolation of insertion mutantsJ. Bacteriol. 174 (15), 4928-4934 (1992)PubMed: 1321118Martin,M.E., Byers,B.R., Olson,M.O., Salin,M.L., Arceneaux,J.E. and Tolbert,C.A Streptococcus mutans superoxide dismutase that is active witheither manganese or iron as a cofactorJ. Biol. Chem. 261 (20), 9361-9367 (1986)PubMed: 3722201Poyart,C., Quesne,G., Coulon,S., Berche,P. and Trieu-Cuot,P.Identification of streptococci to species level by sequencing thegene encoding the manganese-dependent superoxide dismutaseJ. Clin. Microbiol. 36 (1), 41-47 (1998)PubMed: 9431917","Gerlach,D., Reichardt,W. and Vettermann,S.Extracellular superoxide dismutase from Streptococcus pyogenes type 12 strain is manganese-dependentFEMS Microbiol. Lett. 160 (2), 217-224 (1998)PubMed: 9532741Gibson,C.M. and Caparon,M.G.Insertional inactivation of Streptococcus pyogenes sod suggeststhat prtF is regulated in response to a superoxide signalJ. Bacteriol. 178 (15), 4688-4695 (1996)PubMed: 8755901Poyart,C., Berche,P. and Trieu-Cuot,P.Characterization of superoxide dismutase genes from gram-positivebacteria by polymerase chain reaction using degenerate primersFEMS Microbiol. Lett. 131 (1), 41-45 (1995)PubMed: 7557308Inaoka,T., Matsumura,Y. and Tsuchido,T.Molecular cloning and nucleotide sequence of the superoxidedismutase gene and characterization of its product from BacillussubtilisJ. Bacteriol. 180 (14), 3697-3703 (1998)PubMed: 9658017Sanders,J.W., Leenhouts,K.J., Haandrikman,A.J., Venema,G. andKok,J.Stress response in Lactococcus lactis: cloning, expressionanalysis, and mutation of the lactococcal superoxide dismutase geneJ. Bacteriol. 177 (18), 5254-5260 (1995)PubMed: 7665513Bowler,C., Van Kaer,L., Van Camp,W., Van Montagu,M., Inze,D. andDhaese,P.Characterization of the Bacillus stearothermophilus manganesesuperoxide dismutase gene and its ability to complement copper/zinc superoxide dismutase deficiency in Saccharomyces cerevisiaeJ. Bacteriol. 172 (3), 1539-1546 (1990)PubMed: 2407726","Tue Mar 26 08:49:08 2002","Tue Mar 26 08:49:08 2002","1","","","SMU.629","545" "SMu0572","589431","590486","1056","GTGAATAAAAAACAGTCAGTTATATTAGGTGTTTGCATTGTTTTAGCTATCATATGTTTAGCATTCGTTTTACAATCGAAACACATTATGAAGCAGTCATTTTTTAATAATCACTCAATAGGTCAGAGAAAGAAAAACAGCAGTGCTAAGACTCCCGAATCAAGTGAACCAGCTCCTCAAGTTATTGAAAAAACAGCAGAAGAGAAACAGGCTATCGTAGATGCTGATGCAGCAAGAATGGATGCTCTTGGCTTACATTATGATTATGCCAATCTCACACTTCCGCAAGTTGTTCAAACTTATATGGATGAAATGGGGATTGATCATGCAAATATCGCTTTCTCTTATAAAAATACAAAGACCAATGAGGTCATTGCGATGAATGAAACACAGCCTATGACAGCAGGTTCAACTTATAAATTACCTTTAAATATGTTAGCCGTTGATGCCGTTGAAAAAGGAAAACTATCAATGGATACTCCCTATGATATTACAGATCTTGATTATGAATATGCTGGGGAATATCAGGCCTATCGTAATCAATTTGGTAATGATATGACAATTTCTGAGATGCAGGAATATTCTTTGGTTTACTCTGAGAATACACCTGCTTATGCTATGGCCAAGGCGCTTGGTGGTTTTGATAAGGTTTATCCAATGTTTAAACGTTATGGCCAATCCAAGGGTGATATCAAAACAATTGACCAAAATGGTAATAAGACAACGACAGATTATTATATCCAAGTACTTGATTATCTTTGGAAACACCAAGATAAATATGCTGATATTCTTAATTATCTTAGTCAATCTTTTCCAAATTTGTATTATAAGACGTATCTGCCAGATATTGATATTCGTCAGAAGCCTGGTTATGTCAGAGAGGCCTTAAATATTGATGCTATTGTTTATGAGCAGACACCATATTTAATTGCAATTTATACAGCTGGCTTAGGGGGTGTGACATCTGATAATGATGAGGTTAATGGTCTCGGTTATTCACAGTTGTGTCAGCTTACCTATGTTATCAATGAATGGCATCGTGTTAATCGAAATTAA","5.00","-8.68","39790","MNKKQSVILGVCIVLAIICLAFVLQSKHIMKQSFFNNHSIGQRKKNSSAKTPESSEPAPQVIEKTAEEKQAIVDADAARMDALGLHYDYANLTLPQVVQTYMDEMGIDHANIAFSYKNTKTNEVIAMNETQPMTAGSTYKLPLNMLAVDAVEKGKLSMDTPYDITDLDYEYAGEYQAYRNQFGNDMTISEMQEYSLVYSENTPAYAMAKALGGFDKVYPMFKRYGQSKGDIKTIDQNGNKTTTDYYIQVLDYLWKHQDKYADILNYLSQSFPNLYYKTYLPDIDIRQKPGYVREALNIDAIVYEQTPYLIAIYTAGLGGVTSDNDEVNGLGYSQLCQLTYVINEWHRVNRN","590483","","conserved hypothetical protein","Extracellular, Membrane","Limited matches in gapped BLAST to hypothetical proteins:residues 158-351 are 65% and residues 73-149 are 57% similar to hypothetical protein from S.pyogenes (gi15675323) and (gi15675324).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0795 (1e-107).","

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[97-279]T$	no description
signalp	$\"[1-26]?$	signal-peptide
tmhmm	$\"[5-25]?$	transmembrane_regions

InterPro
IPR011397
Family

Protein of unknown function UCP033101
PIRSF033101	$\"[1-251]T$	UCP033101

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 24-225 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD122185) which is seen in O07601_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 09:48:15 2002","Tue Dec 11 15:21:29 2001","Tue Mar 19 09:48:15 2002","Tue Dec 11 15:21:29 2001","","Tue Dec 11 15:21:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0573 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 11 15:23:56 2001","","No significant hits to the NCBI PDB database.","SMU.631","","No significant hits to the Pfam 11.0 database","Tue Dec 11 15:21:29 2001","24379104","","","","","","1","","","SMU.631","" "SMu0574","591478","591942","465","ATGGATAAACAATTACTCATTGCTTTTAATCAGAAATTTCAAGATTTTCTTGCGACCTATGCTCAATTAGAAAAAAATCAGCATGTGATAAAAGGTGCTATCCCTCTCAATACAGCAGAAGTGCATACCCTTGTTAGTATTGCTCAAAATCAACCTATCAATTTGGTCGGCCTGTCAAAAGTGCGAGGAATCTCTCGTAGTGCTGTGACTCAAATGGTTTCAAGATTAGAAAGCAAAGGGCTTTTAATTAAAGTTCCTAATGAAAGTAATCGTCAGGAAATGTTATTGTCTTTAACAAGGGCTGGCCAGAAAATTTATCAGGTTCATCAAAAGCAGCACGCTTATCTTGAAAAGAAAGTGATGGCTGTTTTACAAGCCTATCCTCAAGATTTCTTAGCCAATTTGGAAGCGATGATGGCTGATCTGGAAAAAATTTGGAAAGGATTGCCTTGGTTATCAAGGTAA","10.60","7.95","17481","MDKQLLIAFNQKFQDFLATYAQLEKNQHVIKGAIPLNTAEVHTLVSIAQNQPINLVGLSKVRGISRSAVTQMVSRLESKGLLIKVPNESNRQEMLLSLTRAGQKIYQVHQKQHAYLEKKVMAVLQAYPQDFLANLEAMMADLEKIWKGLPWLSR","591939","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator: residues 7-134 are 29% similar to the protein in Clostridium acetobutylicum (gi|15893457|).Residues 22-145 are 25% similar to the protein in Bacillus halodurans (gi|15614624|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0343 (2e-05).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PR00598	$\"[53-69]T$ $\"[70-85]T$ $\"[89-105]T$	HTHMARR
PF01047	$\"[36-105]T$	MarR
SM00347	$\"[29-129]T$	HTH_MARR
PS50995	$\"[1-147]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[8-114]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[10-141]T$	SSF46785

","BeTs to 5 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class: KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","***** IPB000835 (Bacterial regulatory protein, MarR family) with a combined E-value of 7.2e-09. IPB000835 69-102","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 18 08:10:30 2002","Fri Jan 18 08:10:05 2002","Thu Oct 10 17:19:32 2002","Tue Dec 11 15:25:26 2001","Tue Dec 11 15:25:26 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0574 is paralogously related (blast p-value < 1e-3) to SMu1591,a predicted transcriptional regulator (MarR family), SMu1787,a predicted transcriptional regulator, and SMu1812, a predicted zinc transport transcriptional repressor.","Fri Jan 18 08:10:05 2002","","No significant hits to the NCBI PDB database.","SMU.632","","Residues 36 to 142 (E-value = 1.5e-18) place SMu0574 in the MarR family which is described as MarR family (PF01047)","Tue Dec 11 15:25:26 2001","24379105","","","","","","1","","","SMU.632","" "SMu0575","591989","593218","1230","ATGCTGACATTTAAACTAAAAAGTCAAAATAATCATTTAGCAGATAGTCCTTTTGAGCTTATCATTGAACGTTTGCCCCCTTGCTGTCAAGTAAAAGTGAGACTAGATCTTGATCATTATTATAATATTAATGCTCCAATGAATCTATCTTCTCAGGCTCCTTGGCAGGCAGAAGCTTTGTTTTATTCAGATGATAAGGGAATATTAGATTTATCGGAATCTAATCCTTATCATAACTTGTCCATTATGGAGCTCTTTTTTAAAAGTCAACCGATAGTTTGTAAAAAGGCAAAATTAAGTCAGCAGTTAGAAAGCATTCCCTTAAATCCTTTTTATGATTTGAAAATTAGTATTTTTAAAGGTCACTCTTTATTGGGGGAGACAAGCGTTAGACGTTATTATCAGCTGCCAAGCATCAGTTGTTTAGATTTGAACTTTTCAAGAGCCAAAGGACGGTTTTTTTATGATAAAACGTCTTCTCAACAACCAGCAATCATCGTGTTAAGCGGCAGTGATGGCAGAATTGAAAAGGCACAAAACATTGCGCAGTTATTAGCCAGTCATGGTTTTACCACATTAGCTCTTGCTTATTTTGGTTTGGAAGGTCTTGCCTCTCATTTAGAGAAAATTCCGCTTGAAATTATCCAAGAAGCCATTGATTATTTGAAAAAGTCACCCTATGCGGATAGTATCCGCCTTGGACTTTATGGGCGTTCAAAAGGAGCAGAATTTGCTCTTTTGGCGGCTAGTCATTATGCTGATTTTAAGTGTCTAGTGCTTAATTCTCCTTCTTATCTTTGTTTGGAAGGTCTTAAGCAATGGCGCAATTCTAAGACCTCTTCGTGGACTTATCAAGGACAAGAACTCCCTTATCATCCTTTTTTGTGGAAAGACTTTTTCCAACGTCTTATTTTAAAAAAAGATTTAAAGAATATTAATCATCAGGCTGTTATTCCTGTTGAGAAAATTAATGGTTCTTTATTACTCTTAGTTTCCAAGAAGGATGAAGTTTGGGACGCTTACGGTTCTGCTATAACTATTGTTAACCGACTACAGCAGAAAAGATTTAAATATCCCTATCAAGTAGAAAGTTATGAAAATTGCGGTCATATGATGACGGTAGCCTATCAGCCCAATCACCGTTATAAAAAGGTTGCCCTTGAAAAAATTATGGCTGATACGAATGATTCTTGGCAAAAGACACTTGTATTTTTTAGAAATCGTTTATAG","9.50","12.33","47009","MLTFKLKSQNNHLADSPFELIIERLPPCCQVKVRLDLDHYYNINAPMNLSSQAPWQAEALFYSDDKGILDLSESNPYHNLSIMELFFKSQPIVCKKAKLSQQLESIPLNPFYDLKISIFKGHSLLGETSVRRYYQLPSISCLDLNFSRAKGRFFYDKTSSQQPAIIVLSGSDGRIEKAQNIAQLLASHGFTTLALAYFGLEGLASHLEKIPLEIIQEAIDYLKKSPYADSIRLGLYGRSKGAEFALLAASHYADFKCLVLNSPSYLCLEGLKQWRNSKTSSWTYQGQELPYHPFLWKDFFQRLILKKDLKNINHQAVIPVEKINGSLLLLVSKKDEVWDAYGSAITIVNRLQQKRFKYPYQVESYENCGHMMTVAYQPNHRYKKVALEKIMADTNDSWQKTLVFFRNRL","593215","","thioesterase","Cytoplasm","Weak matches in gapped BLAST to acyl-CoA thioesterase 1: residues 13-406 are 29% similar to the enzyme in Clostridium acetobutylicum (gi|15896648|) and residues 20-409 are 25% similar to peroxisomal long-chain acyl-coA thioesterase from Homo sapiens gi|13623465| SMu0575 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR014940
Domain

BAAT/Acyl-CoA thioester hydrolase C-terminal
PF08840	$\"[210-407]T$	BAAT_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[161-385]T$	G3DSA:3.40.50.1820
SSF53474	$\"[132-402]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 43-378 are 24% similar to a (HYDROLASE ACYL-COA THIOESTER PEROXISOMAL) protein domain (PD006914) which is seen in CTE1_RAT.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 18 08:24:19 2002","Fri Jan 18 08:14:26 2002","Thu Oct 10 17:21:48 2002","Tue Dec 11 16:04:29 2001","","Tue Dec 11 16:04:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0575 is paralogously related (blast p-value < 1e-3) to SMu1530,a predicted acyl-CoA thioesterase 1.","Fri Jan 18 08:14:26 2002","","No significant hits to the NCBI PDB database.","SMU.633","","No significant hits to the Pfam 11.0 database","Tue Dec 11 16:04:29 2001","24379106","","","Huang YT, Liaw YC, Gorbatyuk VY, Huang TH.Backbone dynamics of Escherichia coli thioesterase/protease I: evidence of a flexible active-site environment for a serine protease.J Mol Biol. 2001 Apr 6;307(4):1075-90.PMID: 11286557 Li J, Derewenda U, Dauter Z, Smith S, Derewenda ZS.Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme.Nat Struct Biol. 2000 Jul;7(7):555-9.PMID: 10876240 ","","Fri Jan 18 08:24:19 2002","1","","","SMU.633","" "SMu0576","594432","593404","1029","TTGAATACAAGTGACTTTGATTTTAACCTGCCTGAAGCATTAATTGCCCAAACTCCCCTTAAAAAGCGCGACAGTTCCAAACTTTTAGTCGTTGATCATCAGAAGAAAACAATGAAAGATACCCATTTTGATCATATTATTGACGAGCTCAATTCAGGTGATGCTTTAGTTATGAATGATACACGTGTCCTGCCTGCCCGTCTTCATGGTGAGAAAACAGTGACACACGGTCATGTAGAATTGCTGCTTCTAAAAAATATTCAGGGAGATCAATGGGAGGTTTTAGCAAAACCGGCTAAACGTCTTAAGGTCGGCAGTCATATTTCCTTTGGAGATGGCCGCTTAAAAGCTATCATCAAAGAAGAATTGGATCATGGCGGACGCATTGTGGAATTTTCTTACGAGGGTATTTTCCTGGAAGTCTTAGAAAGCCTTGGAGAGATGCCCTTGCCACCTTATATTCATGAAAAATTAGAAGACCGTGACCGTTATCAGACCGTTTATGCTAAGGAAAATGGCTCTGCTGCTGCCCCAACAGCTGGCCTCCATTTTACAGAAGAGCTCTTAAGCAAAATCGAAGCCAAAGGCGTTAAACTAGTCTATTTGACTCTGCATGTAGGACTAGGAACTTTTCGTCCAGTCTCAGTTGACAATGTGGAAGAGCACCAAATGCATTCCGAATTCTACAGCCTATCACCAGAGGCTGCCCAAACACTAAAAGATGTCAAAGCAAATGGCGGTCGTATTGTGGCAGTTGGGACAACGTCAATTCGTACTTTAGAAACTATCGGTAATAAATTTGCTGGGCAAATTGAAGCAGATTCTGGTTGGACCAACATTTTTATTAAACCGGGCTATCAATTTAAAATTGTTGATGCTTTTTCAACTAATTTTCATCTTCCAAAATCAACTCTAGTCATGCTAGTCTCAGCTTTTGCAGGACGTGATTTTATCCTTGATGCTTATAAGCATGCGGTTGATAAACATTATCGCTTCTTTAGCTTTGGCGATGCTATGTTTGTAAAATAA","6.70","-2.13","38249","MNTSDFDFNLPEALIAQTPLKKRDSSKLLVVDHQKKTMKDTHFDHIIDELNSGDALVMNDTRVLPARLHGEKTVTHGHVELLLLKNIQGDQWEVLAKPAKRLKVGSHISFGDGRLKAIIKEELDHGGRIVEFSYEGIFLEVLESLGEMPLPPYIHEKLEDRDRYQTVYAKENGSAAAPTAGLHFTEELLSKIEAKGVKLVYLTLHVGLGTFRPVSVDNVEEHQMHSEFYSLSPEAAQTLKDVKANGGRIVAVGTTSIRTLETIGNKFAGQIEADSGWTNIFIKPGYQFKIVDAFSTNFHLPKSTLVMLVSAFAGRDFILDAYKHAVDKHYRFFSFGDAMFVK","593407","From Genbank:[gi:3914532]This protein synthesizes OQ from preQ1 in a single S-adenosylmethionine-(adomet-) requiring step.The ribosyl moiety of adomet is transferred and isomerized to the epoxycyclopentaneresidue of OQ .","S-adenosylmethionine--tRNA ribosyltransferase-isomerase (queuosine (Q) biosynthesis protein)","Cytoplasm","Several matches in gapped BLAST to S-adenosylmethionine-tRNA ribosyltransferase-isomerase: residues 1-341 are 85% similar to the enzyme in S.pyogenes (gi15675321) and 78% similar to the enzyme in S.pneumoniae (gi15903316).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0797 (1e-170).","

InterPro
IPR003699
Family

Queuosine biosynthesis protein
PF02547	$\"[1-216]T$	Queuosine_synth
TIGR00113	$\"[1-342]T$	queA: S-adenosylmethionine:tRNA ribosyltran

","BeTs to 8 clades of COG0809COG name: S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)Functional Class: JThe phylogenetic pattern of COG0809 is -----qvceb-huj--o---xNumber of proteins in this genome belonging to this COG is 1","***** IPB003699 (Queuosine biosynthesis protein) with a combined E-value of 1.6e-121. IPB003699A 1-31 IPB003699B 43-72 IPB003699C 140-156 IPB003699D 160-197 IPB003699E 246-261 IPB003699F 291-341","Residues 1-341 are 73% similar to a (QUEUOSINE BIOSYNTHESIS TRANSFERASE) protein domain (PD009740) which is seen in QUEA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 09:55:35 2002","Mon Sep 11 10:33:59 2006","Mon Sep 11 10:32:01 2006","Wed Dec 12 11:06:32 2001","Wed Dec 12 11:06:32 2001","Wed Dec 12 11:06:32 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0576 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 11:08:46 2001","","No significant hits to the NCBI PDB database.","SMU.634c","","Residues 1 to 216 (E-value = 3.2e-110) place SMu0576 in the Queuosine_synth family which is described as Queuosine biosynthesis protein (PF02547)","Wed Dec 12 11:06:32 2001","","","","Reuter,K., Slany,R., Ullrich,F. and Kersten,H.Structure and organization of Escherichia coli genes involved inbiosynthesis of the deazaguanine derivative queuine, a nutrientfactor for eukaryotesJournal of bacteriology. 173 (7), 2256-2264 (1991)PubMed: 1706703Slany,R.K., Bosl,M., Crain,P.F. and Kersten,H.A new function of S-adenosylmethionine: the ribosyl moiety ofAdoMet is the precursor of the cyclopentenediol moiety of the tRNAwobble base queuineBiochemistry. 32 (30), 7811-7817 (1993)PubMed: 8347586Slany,R.K. and Kersten,H.The promoter of the tgt/sec operon in Escherichia coli is precededby an upstream activation sequence that contains a high affinityFIS binding siteNucleic Acids Res. 20 (16), 4193-4198 (1992)PubMed: 1508713","","Wed Dec 12 11:19:15 2001","1","","","SMU.634c","326" "SMu0577","594570","595289","720","ATGACAAAAGGAATTGAAACTATGGGGGAAGAAAAAATAGTACAAAAAGATGATAATTTTTCAGGACGTCTCAATATTTTAAGAGCAGGTGTCTTAGGAGCTAATGATGGTATTATTTCGGTCGCAGGAGTCGTCATTGGGGTTGCCAGTGCAACAACAAATATTTGGTTTATCTTCCTGTCAGGGCTCTCGGCTATTCTTGCAGGGGCTTTTTCTATGGCAGGTGGAGAATATGTCAGTGTTAGTACGCAAAAGGATACTGAAGAGGCCGCTGTTAAGCGAGAAAAGGCTCTTTTATTGACTGATAGTGAAAAGGCAAGACGCTCCCTTCATAATGCCTACCTTAAAAATGGTGAATGTGAAACTTCCGCTGAACTTTTAACCAGAAAGGCTTTTTTAAAATCACCTGTAAAGGCTATGGTTGAAGAAAAATATGGGATTGAGTACGAAGAGTTTGTTAATCCTTGGCATGCTGCTGTTTCAAGCTTTTTTGCTTTTACAATCGGTTCTATATTTCCTGTAATAGCCATTTTGCTGTTTCCAGTTACGATTCGCATTCCGGCAACAGTCATTGTTGTTGGGTTAGCGCTTCTCATGACCGGCTATGTCAGTGCTAGACTTGGCGGTGCGCCAACTAGACCAGCTATGAGACGTAATTTGATAGTGGGACTATTAACCATGCTAGTTACTTATTTAGTGGGACAACTTTTTTCAGTTTAA","9.10","2.44","25695","MTKGIETMGEEKIVQKDDNFSGRLNILRAGVLGANDGIISVAGVVIGVASATTNIWFIFLSGLSAILAGAFSMAGGEYVSVSTQKDTEEAAVKREKALLLTDSEKARRSLHNAYLKNGECETSAELLTRKAFLKSPVKAMVEEKYGIEYEEFVNPWHAAVSSFFAFTIGSIFPVIAILLFPVTIRIPATVIVVGLALLMTGYVSARLGGAPTRPAMRRNLIVGLLTMLVTYLVGQLFSV","595286","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 52-239 are 69% similar to S.pneumoniae (gi|15902858|) and residues 23-236 are 35% similar to Lactococcus lactis subsp. lactis (gi|15673456|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0798 (2e-72).","

InterPro
IPR008217
Family

Protein of unknown function DUF125, transmembrane
PF01988	$\"[26-236]T$	DUF125

","BeTs to 3 clades of COG1814COG name: Uncharacterized membrane proteinsFunctional Class: SThe phylogenetic pattern of COG1814 is Amtky-v--------------Number of proteins in this genome belonging to this COG is 1","***** IPB002839 (Integral membrane protein DUF125) with a combined E-value of 1.4e-12. IPB002839A 31-47 IPB002839B 54-78 IPB002839C 167-178","Residues 137-234 are 37% similar to a (PROTEOME COMPLETE YPAD YPAE) protein domain (PD414521) which is seen in Q9CFK2_LACLA.Residues 146-239 are 36% similar to a (PROTEOME COMPLETE 21-RELATED NODULIN) protein domain (PD329023) which is seen in Q9P6J2_SCHPO.Residues 154-239 are 36% similar to a (PROTEOME COMPLETE MEMBRANE PA3851) protein domain (PD414543) which is seen in Q9HXF5_PSEAE.Residues 27-126 are 36% similar to a (PROTEOME COMPLETE NODULIN-LIKE CCC1) protein domain (PD109783) which is seen in Q9CFK2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 18 08:25:40 2002","Wed Dec 12 11:20:28 2001","Fri Jan 18 08:25:40 2002","Wed Dec 12 11:20:28 2001","Wed Dec 12 11:20:28 2001","Wed Dec 12 11:20:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0577 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 11:22:41 2001","","No significant hits to the NCBI PDB database.","SMU.635","","Residues 26 to 236 (E-value = 2.1e-60) place SMu0577 in the DUF125 family which is described as Integral membrane protein DUF125 (PF01988)","Wed Dec 12 11:20:28 2001","24379108","","","","","","1","","","SMU.635","663" "SMu0578","595419","596120","702","ATGAAAACTATTAAAGTAAAAAATAAAACAGAAGGTAGTAAAGTTGCTTTTAGAATGTTAGAAGAAGAAATAACATTCGGTGCTAAGACTCTGGGGCTAGCGACTGGTAGCACCCCTTTAGAGCTCTATAAAGAAATAAGAGAATCTCATTTAGACTTTTCAGATATGGTATCTATTAATCTTGATGAATATGTTGGTTTGTCAGCCGATGATAAGCAGTCTTATGCTTATTTTATGAAGCAAAATCTTTTTGCTGCTAAACCTTTTAAAAAGTCTTATTTGCCAAACGGACTGGCAGCAGATTTAGCAAAAGAGACAGAGTATTATGATCAAATTCTTGCCCAATATCCTATTGATTTACAGATTTTAGGGATTGGCCGCAATGCTCACATTGGTTTTAATGAGCCAGGGACAGCATTTTCAAGTCAAACGCATCTAGTTGATTTAACACCGTCTACAATTGCAGCTAATAGCCGTTTTTTTGAAAAAGCAGAAGATGTTCCAAAACAAGCTATTTCTATGGGACTGGCCTCTATTATGTCTGCCAAGATGATTTTACTAATGGCTTTTGGTGAAGAAAAAGCAGAGGCTGTTGCTGCAATGGTAAAAGGCCCTGTAACAGAAGAAATACCAGCTAGTATACTGCAAACACATCCTAAGGTTATTTTGATTGTTGATGAAAAAGCAGGAGCAGGAATTTAA","5.30","-5.03","25459","MKTIKVKNKTEGSKVAFRMLEEEITFGAKTLGLATGSTPLELYKEIRESHLDFSDMVSINLDEYVGLSADDKQSYAYFMKQNLFAAKPFKKSYLPNGLAADLAKETEYYDQILAQYPIDLQILGIGRNAHIGFNEPGTAFSSQTHLVDLTPSTIAANSRFFEKAEDVPKQAISMGLASIMSAKMILLMAFGEEKAEAVAAMVKGPVTEEIPASILQTHPKVILIVDEKAGAGI","596117","For other 'nag' genes see SMu1290 (nagD).","glucosamine-6-phosphate isomerase","Cytoplasm, Membrane","Several matches in gapped BLAST to N-acetylglucosamine-6-phosphate isomerase: residues 1-231 are 61% similar to the enzyme in S.pyogenes (gi15675320). Residues 1-229 are 61% similar to the protein from S.pneumonia (gi15903315).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0799 (7e-78).","

InterPro
IPR004547
Family

Glucosamine-6-phosphate isomerase
PTHR11280	$\"[15-229]T$	NagB

InterPro
IPR006148
Domain

Glucosamine/galactosamine-6-phosphate isomerase
PF01182	$\"[15-233]T$	Glucosamine_iso

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1360	$\"[1-233]T$	G3DSA:3.40.50.1360
SSF100950	$\"[1-233]T$	SSF100950

","BeTs to 6 clades of COG0363COG name: Glucosamine-6-phosphate deaminase (Glucosamine-6-phosphate isomerase)Functional Class: GThe phylogenetic pattern of COG0363 is ----Y-vcEBrHuj--Olin-Number of proteins in this genome belonging to this COG is 1","***** IPB000457 (Glucosamine/galactosamine-6-phosphate isomerase) with a combined E-value of 3.5e-44. IPB000457A 26-68 IPB000457B 108-160 IPB000457C 175-229 IPB000457A 30-72","Residues 88-191 are 65% similar to a (ISOMERASE DEAMINASE) protein domain (PD006132) which is seen in Q9CFA8_LACLA.Residues 29-78 are 70% similar to a (ISOMERASE DEAMINASE) protein domain (PD007348) which is seen in Q9CFA8_LACLA.Residues 118-226 are 29% similar to a (ISOMERASE GALACTOSAMINE-6-PHOSPHATE) protein domain (PD398727) which is seen in AGAI_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 26 17:00:19 2006","Wed Jul 26 17:00:19 2006","Wed Jul 26 16:58:02 2006","Wed Dec 12 12:40:29 2001","Wed Dec 12 12:40:29 2001","Wed Dec 12 12:40:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0578 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 12:42:44 2001","Wed Jul 26 16:58:02 2006","pdb1DEAA Chain A, Mol_id: 1; Molecule: Glucosamine 6-Phosphat... 130 1e-031pdb1D9TA Chain A, Human Glucosamine-6-Phosphate Deaminase Iso... 121 9e-029","SMU.636","","Residues 15 to 233 (E-value = 2.5e-40) place SMu0578 in the Glucosamine_iso family which is described as Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase (PF01182)","Wed Dec 12 12:40:29 2001","24379109","","","Rogers,M.J., Ohgi,T., Plumbridge,J. and Soll,D.Nucleotide sequences of the Escherichia coli nagE and nagB genes:the structural genes for the N-acetylglucosamine transport proteinof the bacterial phosphoenolpyruvate: sugar phosphotransferasesystem and for glucosamine-6-phosphate deaminaseGene 62 (2), 197-207 (1988)PubMed: 3284790Peri,K.G., Goldie,H. and Waygood,E.B.Cloning and characterization of the N-acetylglucosamine operon ofEscherichia coliBiochem. Cell Biol. 68 (1), 123-137 (1990)PubMed: 2190615Altamirano,M.M., Plumbridge,J.A. and Calcagno,M.L.Identification of two cysteine residues forming a pair of vicinalthiols in glucosamine-6-phosphate deaminase from Escherichia coliand a study of their functional role by site-directed mutagenesisBiochemistry 31 (4), 1153-1158 (1992)PubMed: 1734962Oliva,G., Fontes,M.R., Garratt,R.C., Altamirano,M.M., Calcagno,M.L. and Horjales,E.Structure and catalytic mechanism of glucosamine 6-phosphatedeaminase from Escherichia coli at 2.1 A resolutionStructure 3 (12), 1323-1332 (1995)PubMed: 8747459Horjales,E., Altamirano,M.M., Calcagno,M.L., Garratt,R.C. andOliva,G.The allosteric transition of glucosamine-6-phosphate deaminase: the structure of the T state at 2.3-A resolutionStructure 7, 527-537 (1999)","","Wed Dec 12 12:57:52 2001","1","","","SMU.636","664" "SMu0579","596816","596313","504","ATGACATCACAGACAATACTGAGGATTACTCCCCCAACCGGACTACAGGCTAACATTGATGTCATGAATGATTTTATTTATCCTAATATCATGGGGATTACAAGGCAGGCTTTGCTACTTCTCAGGAAGTTTATGAAGAAGAGGCGCAAACTCTCTTTGCTGCGCTGGATAAACATGAAAATCTCCTTAGTCAGAATGATTGGCTGGTGGGCAAACGTTTCACCGAAGTGGATATCGGTCTCTTCACAACACTTGTACATTTTGACTCTGTTTATTATAGACATTTCAAATGCAATCTCCGCCACCTCGTTGACTATCTCAATCACTGGAATCACACCAAGCGCATTTACAATATCTCTAGCATTGCTACTACGGTTAACTTTAAGCATATTAAAAACATTACTACGGCAGCCACAAGACCATCAATCTTACAAGTATCGTTTCTGTCGGACCAGATTTGGGTTGGTATCTTTAAAAAGAGACACTGAAAAGTTTAAAACATAG","11.80","18.41","19285","MTSQTILRITPPTGLQANIDVMNDFIYPNIMGITRQALLLLRKFMKKRRKLSLLRWINMKISLVRMIGWWANVSPKWISVSSQHLYILTLFIIDISNAISATSLTISITGITPSAFTISLALLLRLTLSILKTLLRQPQDHQSYKYRFCRTRFGLVSLKRDTEKFKT","596316","","hypothetical protein","Membrane, Cytoplasm","No significant hits using gapped BLAST found.SMu0579 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[51-71]?$ $\"[90-124]?$	transmembrane_regions

InterPro
IPR000748
Domain

Pseudouridine synthase, Rsu
TIGR00093	$\"[66-227]T$	Psi__synth_RSU

InterPro
IPR002035
Domain

von Willebrand factor, type A
PR00453	$\"[84-101]T$ $\"[178-186]T$	VWFADOMAIN

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[1-47]T$	S4
SM00363	$\"[1-64]T$	S4
PS50889	$\"[1-67]T$	S4

InterPro
IPR006145
Domain

Pseudouridine synthase
PF00849	$\"[61-196]T$	PseudoU_synth_2

noIPR
unintegrated

unintegrated
PTHR21600	$\"[5-234]T$	PTHR21600
PTHR21600:SF2	$\"[5-234]T$	PTHR21600:SF2
SSF55120	$\"[60-234]T$	SSF55120
SSF55174	$\"[2-88]T$	SSF55174

","BeTs to 11 clades of COG1187COG name: Predicted pseudouridylate synthase family 1Functional Class: JThe phylogenetic pattern of COG1187 is -----QvCEBrHuj--olinxNumber of proteins in this genome belonging to this COG is 3","***** IPB000748 (Pseudouridine synthase, Rsu family) with a combined E-value of 4.6e-40. IPB000748A 2-27 IPB000748B 66-81 IPB000748C 99-131 IPB000748D 180-214***** IPB000613 (Pseudouridine synthase) with a combined E-value of 3.7e-06. IPB000613A 55-75 IPB000613B 99-138 IPB000613C 184-208","Residues 133-229 are 43% similar to a (SYNTHASE COMPLETE PSEUDOURIDINE PROTEOME) protein domain (PD003862) which is seen in YTZF_BACSU.Residues 70-131 are 48% similar to a (SYNTHASE PROTEOME COMPLETE PSEUDOURIDINE RIBOSOMAL) protein domain (PD033985) which is seen in Q9KWZ9_STAAU.Residues 1-68 are 41% similar to a (SYNTHASE COMPLETE PROTEOME PSEUDOURIDINE RIBOSOMAL) protein domain (PD004022) which is seen in Q9K7T6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 26 17:25:24 2006","Wed Jul 26 17:25:24 2006","Wed Jul 26 17:25:24 2006","Wed Dec 12 13:01:37 2001","Wed Dec 12 13:01:37 2001","Wed Dec 12 13:01:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0580 is paralogously related (blast p-value < 1e-3) to SMu1559,a predicted ribosomal large subunit pseudouridine synthase B, and SMu0953, a predicted pseudouridine synthase.","Fri Jan 18 08:29:00 2002","","No significant hits to the NCBI PDB database.","SMU.638","","Residues 1 to 47 (E-value = 5.7e-05) place SMu0580 in the S4 family which is described as S4 domain (PF01479)Residues 61 to 196 (E-value = 7.2e-09) place SMu0580 in the PseudoU_synth_2 family which is described as RNA pseudouridylate synthase (PF00849)","Wed Jul 26 17:25:24 2006","24379111","","","","","","1","","","SMU.638","665" "SMu0581","597866","598366","501","ATGACTACCACTATCCGTCAAATGATAGCAGAAGAATATTCACTTTTGGAGGAATTTCTTTATCAAGCCATTTTTGTACCTCAAGGATTATCAGCACCTGATAGAAGTATTATCCAGCTGCCGGAGCTGCAGCTTTATGTGAAGGATTTTGGGCAATCTCTACATGATCAAGCCATGGTGGCAGAAAGAGACGGGCAAATTGTTGGTACTGCTTGGTGTCGTATCATGGATGATTACGGTCATATTGATGAGAAGACACCTTCTCTAGCCATATCTCTGCTGCCTGCTTATCGCGGACAAGGAATTGGTACCGAATTGCTCAAGACTTTCTTAGAACATCTCAGGAAGAAAGGCTATCACAAGGTTTCTTTATCTGTCCAAAAGGAAAATGATGCTGTTAACATGTATCAAAAGGCTGGTTTTCAGACCATTATTGAAAATGAGACAGATTTTATCATGGTTTGTGATTTACAGACAGAGGGAATAGATTATTTTTCCTAA","4.60","-9.13","18901","MTTTIRQMIAEEYSLLEEFLYQAIFVPQGLSAPDRSIIQLPELQLYVKDFGQSLHDQAMVAERDGQIVGTAWCRIMDDYGHIDEKTPSLAISLLPAYRGQGIGTELLKTFLEHLRKKGYHKVSLSVQKENDAVNMYQKAGFQTIIENETDFIMVCDLQTEGIDYFS","598363","","N-terminal acetyltransferase","Cytoplasm","Limited matches in gapped BLAST to N-terminal acetyltransferase: residues 50-142 are 36% similar to the enzyme in Pyrococcus abyssi (gi|14521872|). Residues 89-149 are 45% similar to the protein from Deinococcus radiodurans (gi|15807730|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1977 (1e-06).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[59-142]T$	Acetyltransf_1
PS51186	$\"[3-158]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[1-166]T$	G3DSA:3.40.630.30
PTHR23091	$\"[46-148]T$	PTHR23091
PTHR23091:SF1	$\"[46-148]T$	PTHR23091:SF1
SSF55729	$\"[1-144]T$	SSF55729

","BeTs to 5 clades of COG0456COG name: AcetyltransferasesFunctional Class: RThe phylogenetic pattern of COG0456 is amtkYqvcebrh---------Number of proteins in this genome belonging to this COG is 2","***** IPB000182 (GCN5-related N-acetyltransferase) with a combined E-value of 1.8e-06. IPB000182A 98-107 IPB000182B 135-141","Residues 60-142 are 37% similar to a (COMPLETE PROTEOME TRANSFERASE) protein domain (PD339986) which is seen in Q9UY34_PYRAB.Residues 89-149 are 45% similar to a (PROTEOME TRANSFERASE ACETYLTRANSFERASE) protein domain (PD358969) which is seen in Q9RZ92_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 18 08:30:58 2002","Fri Oct 11 12:44:13 2002","Fri Oct 11 12:32:57 2002","Wed Dec 12 13:11:09 2001","Wed Dec 12 13:11:09 2001","Wed Dec 12 13:11:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0581 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 13:14:24 2001","","No significant hits to the NCBI PDB database.","SMU.639","","Residues 59 to 142 (E-value = 3.1e-21) place SMu0581 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Wed Dec 12 13:11:09 2001","24379112","","","","","","1","","","SMU.639","" "SMu0582","599829","598456","1374","ATGCCTGTTAATTCATTTGACAATTATCCTATGACTTGGAAACCAGATAAACAATTGTTAAAAGCTCCTCTATATACCAGCCTAGCTAAACTCTTAGAGAAAGATATTATAGAAGGACGTTTGACTGCTGAAACAAAATTGCCACCCCAACGTGAATTAGCTGATTTTTTGGATCTCAATCTAAGTACAGTGACAAGAGCTTTTAAACTCTGTGAACAAAAAGGTCTTATTTACGCTATTATCGGCAAAGGAACCTTTATTTCACCTAATAGGGCGAAACCTTTAGCTACTTTACCAAAAAATGAGACACTTATTCCTCTTGGCAATTTGCATCCTTATTACCAACTTAATTATGTTGTATCTGATATTTCCAGACGAATCTTACAGAGTCAATCTGTTGATAGGCTTTTTGAATTTGACACGAAAAACAATACGCAAGAGCATAAAGCTGTAGCTCAACAATGGTTGAAAAAGTTTCAAATTAACACTCTCAAAGAGAATATCTTTCTAACTTATGGCACACAAAATGCCTTAGTTTTGTTATTTTTAACAGTGTTTAAAGCAGGCGATAAAATAGCGACTGATACATTTACTTACACCAATTTCATTGCCTTAGCTCAGCAATTCAAGATTGAACTTGTCCCAATAATATCTGATCATAAAGGAATCATTCCAGAAGACTTGGAAAAGAAATGTCGCCAGCAAATGATCAAGGGGATTTACTTGGTTCCAACGTCTAATAATCCAACTGGGATGACCATGACATTAGAAAGAAGACAACAACTTGTTTCGTTGATAAGTAAAAACCACCTTCTCCTAATAGAAGATGACACTTATGCTTTTACAAACTATGAAAAATTACCCGCGTTGACAACCATGATTCCTAAACAAGCGATTTATATTCATGGCTTATCAAAAGCCTTGTTTGCTGGTCTGCGAATGGCTTATATGGTGGTGCCTGATTATCTTATTCAAGAGATTAATCTCACTGCTGATGCTATCAATGCCCGTCCACCTCTATTAAATACTAAGATTGTGAGCGATCTCATTTCAAACGGTCAAGCAGATAGTACAATAGCGCAAAAAAATCATTTATCTCAGGAACGAAATGCTCTCTATGATCATTATTTCCCAGAATCCACTTCTTCCAATCCCTACAATTTATTTCAATGGTTACCATTACCTAAAAATAGAAGCGGCTATCAATTTGAATCCTTGGCCAAAGAAAAGGGTGTTGAAGTTTTATGCGCGGAACGCTTTCTTGTCGGTGGACTGACAGCACAGTCTGCTTTGCGCATTGCAACTTGCTCACCAAATACACTAGATGAGCTTGACAAAGGACTCCATATTTTAAAATCTATATTAGAGAAATAA","9.30","7.76","51762","MPVNSFDNYPMTWKPDKQLLKAPLYTSLAKLLEKDIIEGRLTAETKLPPQRELADFLDLNLSTVTRAFKLCEQKGLIYAIIGKGTFISPNRAKPLATLPKNETLIPLGNLHPYYQLNYVVSDISRRILQSQSVDRLFEFDTKNNTQEHKAVAQQWLKKFQINTLKENIFLTYGTQNALVLLFLTVFKAGDKIATDTFTYTNFIALAQQFKIELVPIISDHKGIIPEDLEKKCRQQMIKGIYLVPTSNNPTGMTMTLERRQQLVSLISKNHLLLIEDDTYAFTNYEKLPALTTMIPKQAIYIHGLSKALFAGLRMAYMVVPDYLIQEINLTADAINARPPLLNTKIVSDLISNGQADSTIAQKNHLSQERNALYDHYFPESTSSNPYNLFQWLPLPKNRSGYQFESLAKEKGVEVLCAERFLVGGLTAQSALRIATCSPNTLDELDKGLHILKSILEK","598459","","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulator (GntR family) /aminotransferase (MocR-like): residues 1-456 are 36% similar to the protein in Bacillus subtilis (gi|16077585|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0099 (1e-13).","

InterPro
IPR000524
Domain

Bacterial regulatory protein GntR, HTH
PF00392	$\"[24-87]T$	GntR
SM00345	$\"[28-87]T$	HTH_GNTR
PS50949	$\"[22-90]T$	HTH_GNTR

InterPro
IPR004839
Domain

Aminotransferase, class I and II
PF00155	$\"[102-448]T$	Aminotran_1_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[17-90]T$	Wing_hlx_DNA_bd

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[138-352]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[78-457]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[166-457]T$	PTHR11751
PTHR11751:SF8	$\"[166-457]T$	PTHR11751:SF8
SSF46785	$\"[21-94]T$	SSF46785

","BeTs to 5 clades of COG1167COG name: Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologsFunctional Class: K,EThe phylogenetic pattern of COG1167 is ---kY-v-EB-----------Number of proteins in this genome belonging to this COG is 2","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 4.7e-11. IPB000524 47-87","Residues 167-276 are 40% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9KDT4_BACHD.Residues 170-284 are 25% similar to a (AMINOTRANSFERASE UBP3-PET122 II 2.6.1.-) protein domain (PD202809) which is seen in Q9VTD9_DROME.Residues 24-87 are 60% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD410995) which is seen in P96663_BACSU.Residues 39-87 are 46% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD069824) which is seen in YRDX_RHOSH.Residues 283-455 are 36% similar to a (PROTEOME TRANSCRIPTIONAL REGULATION) protein domain (PD166488) which is seen in P96663_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 08:34:50 2002","Fri Jan 18 08:37:55 2002","Fri Oct 11 12:45:10 2002","Wed Dec 12 13:18:24 2001","Wed Dec 12 13:18:24 2001","Wed Dec 12 13:18:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0582 is paralogously related (blast p-value < 1e-3) to SMu0865,a predicted conserved hypothetical protein; possible transcriptional regulator, SMu0020,a predicted aspartate or aromatic amino acid aminotransferase, SMu1092 and SMu0973,both predicted transcriptional regulators (GntR family),SMu1199,a predicted aspartate aminotransferase, SMu1165,a predicted histidinol-phosphate aminotransferase, SMu1853,a predicted trehalose operon transcriptional repressor (transcriptional regulator,GntR family) and SMu1663, a predicted aminotransferase, class I.","Fri Jan 18 08:37:55 2002","","No significant hits to the NCBI PDB database.","SMU.640c","","Residues 24 to 87 (E-value = 1.9e-14) place SMu0582 in the GntR family which is described as Bacterial regulatory proteins, gntR family (PF00392)","Wed Dec 12 13:18:24 2001","24379113","","","","","","1","","","SMU.640c","" "SMu0583","599957","600925","969","ATGAAGGCAGTTTATATTCAAAAAACGGGAGGACCCGCAACGATTATTGTTGGTTCATTACCTGTTCCCAAAGTTAGACCGAAATCTGTTTTAATAAAAGTTATAGCCGCTTCTATTAATTATGTTGACCTCTTTATTCGTTCAGGTATTTATCAGACAGATCTGCCGAATCCTTATATTTTGGGTCGAGATGCTATCGGCCAAGTTGTTGAGATTGGAAAAGATGTGATTCAGTTTAAAGTAGGCGATTGCGTTTGGACTAATAGTATGGGCTATGATGGAAGGCAAGGTATCACTAGCGAGTATGCATTAATTCCAGAAGAGCGCCTTTTTCTTACTCCCAAGAATGCTGACTCTTTAAAATTAATTGGTGCAGTGCACTCGGCAGCAACGGCAACTATCGTATTACAAGATATCATGGAATTGAAGCCAAAACAAAAACTCCTTATTGAAGGAGCAGCTGGCCATGTGGGAAGTAAGTTGGTTTATCTTGCTAATGAAATGGGGGCAGAGGTGGTAACAACCGCTAGTTTAAAGGATTTTTCAAGATTAAAACAATTGAGCGACGCTATCTGTTTTGATTATCGTGATAAGTCACTCTTTAAGAAACTAAAAAGCGCTTATCCTGATGGTTTCGACCACATTATTGACACTTCTGGGGAAATTCCCTTACAGTTTAATTGCGATTTACTTGCCCCAAAAGGTGTCATTAGTTTAATTACAGCACCGAAAGACAGTCAATTTGATAGCAGACAGTTTTATATGAACTGTCAGCAAATGAAAGGGTTTGTGATTAGTCACGCTAGTTTGAAGCAACTGAAAAAAGCAGGAAGAATTTTAAATGATGCTTTTAGGCAAGGACAATTACTGGAGGAAGACATGGTTATCAAAAAATTTGACAAAGCCGCAGAAGCGCATGATTTGATGGAAACTAAAAAAGAAAATAGAAAAATCATCTTAGTTCCTTAA","9.40","7.02","35594","MKAVYIQKTGGPATIIVGSLPVPKVRPKSVLIKVIAASINYVDLFIRSGIYQTDLPNPYILGRDAIGQVVEIGKDVIQFKVGDCVWTNSMGYDGRQGITSEYALIPEERLFLTPKNADSLKLIGAVHSAATATIVLQDIMELKPKQKLLIEGAAGHVGSKLVYLANEMGAEVVTTASLKDFSRLKQLSDAICFDYRDKSLFKKLKSAYPDGFDHIIDTSGEIPLQFNCDLLAPKGVISLITAPKDSQFDSRQFYMNCQQMKGFVISHASLKQLKKAGRILNDAFRQGQLLEEDMVIKKFDKAAEAHDLMETKKENRKIILVP","600922","","oxidoreductase","Cytoplasm","Matches in gapped BLAST to oxidoreductase: residues 1-322 are 34% similar to the enzyme in S.coelicolor (gi|6689139|). Residues1-320 are 32% similar to the protein from Bacillus halodurans(gi|15613498|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0054 (9e-06).","

InterPro
IPR002085
Family

Alcohol dehydrogenase superfamily, zinc-containing
PTHR11695	$\"[14-322]T$	ADH_Sf_Zn

InterPro
IPR011032
Domain

GroES-like
SSF50129	$\"[1-150]T$	GroES_like

InterPro
IPR013149
Domain

Alcohol dehydrogenase, zinc-binding
PF00107	$\"[144-282]T$	ADH_zinc_N

InterPro
IPR013154
Domain

Alcohol dehydrogenase GroES-like
PF08240	$\"[27-113]T$	ADH_N

noIPR
unintegrated

unintegrated
G3DSA:3.90.180.10	$\"[1-180]T$	G3DSA:3.90.180.10
PTHR11695:SF30	$\"[14-322]T$	PTHR11695:SF30
SSF51735	$\"[116-287]T$	SSF51735

","BeTs to 4 clades of COG0604COG name: NADPH:quinone reductase and related Zn-dependent oxidoreductasesFunctional Class: C,RThe phylogenetic pattern of COG0604 is ----Yq--ebR----------Number of proteins in this genome belonging to this COG is 3","***** IPB002328 (Zinc-containing alcohol dehydrogenase) with a combined E-value of 4.6e-10. IPB002328A 14-45 IPB002328B 58-83***** IPB002364 (Quinone oxidoreductase/zeta-crystallin) with a combined E-value of 2.4e-08. IPB002364 58-85","Residues 1-73 are 45% similar to a (OXIDOREDUCTASE DEHYDROGENASE ZINC ALCOHOL NAD COMPLETE) protein domain (PD225307) which is seen in Q9RCW3_STRCO.Residues 153-252 are 34% similar to a (OXIDOREDUCTASE DEHYDROGENASE ZINC ALCOHOL NAD COMPLETE) protein domain (PD000104) which is seen in O45496_CAEEL.Residues 82-136 are 43% similar to a (PHOSPHOPANTETHEINE TRANSFERASE SYNTHASE OXIDOREDUCTASE) protein domain (PD189697) which is seen in Q9RCW3_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 13:28:18 2002","Fri Jan 18 08:40:18 2002","Fri Oct 11 12:46:15 2002","Wed Dec 12 13:26:04 2001","Wed Dec 12 13:26:04 2001","Wed Dec 12 13:26:04 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0583 is paralogously related (blast p-value < 1e-3) to SMu1005 and SMu0664, all predicted oxidoreductases.","Tue Feb 5 13:28:18 2002","Wed Dec 12 13:26:04 2001","pdb|1QOR|A Chain A, Quinone Oxidoreductase Complexed With Nadph... 66 6e-012","SMU.641","","Residues 10 to 322 (E-value = 6.6e-39) place SMu0583 in the ADH_zinc_N family which is described as Zinc-binding dehydrogenase (PF00107)","Wed Dec 12 13:26:04 2001","24379114","","","","","","1","","","SMU.641","" "SMu0584","601170","601451","282","ATGAATATACTTGATCGCTACTTTGTTTTATCTGATTTAGCAGGAAAGGATAAAAGAAAATTGACAGAACTTTGCAATTTATTTTCAGAGAATGCTATCATAGAAGCTAATGATGGTAACACTTATTCTGGTAGAGAAGAAATTAATCCGTTTTTTGAAAAGTTCTTCAACAAAAATTCAGAATTGAAACATTTATGGGATACTAAAGAAATAGCTGATGACTGGCGCAGGCAAATTGGGCGGTTATATGCCGCAGAAAAACTGGAAAGTACCTTGCTTTGA","5.00","-2.81","10945","MNILDRYFVLSDLAGKDKRKLTELCNLFSENAIIEANDGNTYSGREEINPFFEKFFNKNSELKHLWDTKEIADDWRRQIGRLYAAEKLESTLL","601448","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu0584 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF54427	$\"[1-84]T$	SSF54427

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[17-261]T$	G3DSA:3.40.50.1820
SSF53474	$\"[27-292]T$	SSF53474

","BeTs to 4 clades of COG0657COG name: Acetyl esteraseFunctional Class: IThe phylogenetic pattern of COG0657 is a---y-vcebR------l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 37-125 are 36% similar to a (HYDROLASE COMPLETE PROTEOME ESTERASE) protein domain (PD330224) which is seen in Q9RY19_DEIRA.Residues 37-266 are 31% similar to a (B HYDROLASE COMPLETE SUGAR) protein domain (PD415944) which is seen in Q9CID4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 11:02:52 2002","Fri Oct 11 12:47:37 2002","Fri Oct 11 12:47:37 2002","Wed Dec 12 13:35:22 2001","","Wed Dec 12 13:35:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0585 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 13:35:56 2001","","No significant hits to the NCBI PDB database.","SMU.643","","No significant hits to the Pfam 11.0 database","Wed Dec 12 13:35:22 2001","24379116","","","","","","1","","","SMU.643","" "SMu0586","602758","603696","939","ATGTTAGTTGCAAGGGATAAAAATGGAAAGTTGATTAATCTTCTGAATGGTATTCCTGACAAAAGTGATTTTTATTGTCCTGCCTGCCAATCACCTGTACGTCTCAAAAACGGCAGGGTTATGCGTCCGCATTTTGCCCATGTTGCTTTGCAAGACTGCAAATTTTACAGTGAAAATGAGTCCGCTGAACACCTAAACTTGAAAGCAGAACTCTATCAGTCATTATCTCAGACGGAAAGTGTTGAGATCGAAAAAGTCATACCAGAACCTGAACAAATCGCAGACTTATTAGTTAATCATAACCTAGCATTAGAAGTTCAGTGTTCTCGCTTGTCCGAAGCTCGTCTGTGTGAGCGAACGCAGGCCTATCAGGCCAATGGTTATCAGGTACTGTGGCTGCTTGGGGAGAAACTCTGGTTGGATAGGCGTTTATCCAACTTGCACAAACAATTTCTTTACTTTTCACAAAATATGGGCTTTCATCTTTGGGAATTAGATATTAATAGGCGTGAGTTGCGACTTAAGTACTTGATTTATGAAGATATTTTTGGCAAAGTCTATTATCAAACGAGGTCTTGTTCTTTTGATGGTAATATCATGACCTTTTTACAATTGCCCTATGCTAAGCAAACCTTGACTTCTTATCCTGTTCACCAGCGCAGGCAGGTTGGTTTAGCCATTCAAAAACAACTGCTAGCACGCAATCCGCGTTGGCTGCGTCAGCAAGAACTTGCTTATTCACAGGGGCGTAATCTGATAGCACAATCAGATGCTGATTTTTTCCCGCAGGTAAGGTTACCGCAATGTTCAAGAGGCTTTTGTCAAATCAATCAGGATGTATCTCATTTTAGCGCAGCTTTTTTTCAATATTATCAAAAGCAAAAAGACAAAGAAATTCAAACACTGTATCCGCCAGCCTTTTATGATAAAATGAAATAA","8.80","8.55","36707","MLVARDKNGKLINLLNGIPDKSDFYCPACQSPVRLKNGRVMRPHFAHVALQDCKFYSENESAEHLNLKAELYQSLSQTESVEIEKVIPEPEQIADLLVNHNLALEVQCSRLSEARLCERTQAYQANGYQVLWLLGEKLWLDRRLSNLHKQFLYFSQNMGFHLWELDINRRELRLKYLIYEDIFGKVYYQTRSCSFDGNIMTFLQLPYAKQTLTSYPVHQRRQVGLAIQKQLLARNPRWLRQQELAYSQGRNLIAQSDADFFPQVRLPQCSRGFCQINQDVSHFSAAFFQYYQKQKDKEIQTLYPPAFYDKMK","603693","","competence protein CoiA","Cytoplasm","Limited matches in gapped BLAST to transcription factor/competence protein:residues 1-311 are 54% similar to transcription factor in S.pyogenes (gi15675318).Residues 1-310 are 45% similar to competence protein from S.pneumoniae (gi15902925).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0804 (5e-99).","

InterPro
IPR010330
Family

Competence CoiA-like
PF06054	$\"[1-311]T$	CoiA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 115-308 are 35% similar to a (PROTEOME FACTOR TRANSCRIPTION COMPLETE) protein domain (PD037504) which is seen in P94875_BBBBB.Residues 1-112 are 49% similar to a (PROTEOME COMPLETE YJBF TRANSCRIPTION) protein domain (PD037505) which is seen in Q9CEV6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 11:03:59 2002","Tue Aug 29 16:42:07 2006","Thu Jun 23 13:53:52 2005","Wed Dec 12 13:38:09 2001","","Wed Dec 12 13:38:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0586 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 13:41:12 2001","","No significant hits to the NCBI PDB database.","SMU.644","","Residues 1 to 311 (E-value = 4.5e-159) place SMu0586 in the CoiA family which is described as Competence protein CoiA-like family (PF06054)","Wed Dec 12 13:38:09 2001","24379117","","","Pestova,E.V. and Morrison,D.A.Isolation and characterization of three Streptococcus pneumoniaetransformation-specific loci by use of a lacZ reporter insertionvectorJ. Bacteriol. 180 (10), 2701-2710 (1998)PubMed: 9573156","","Wed Dec 12 13:43:56 2001","1","","","SMU.644","546" "SMu0587","603718","605517","1800","ATGTCTGATAATCGCAGTCATATTGAAGAAAAATACCAATGGGATTTGACCAGCATTTTTCCAAACGATCAAACTTGGGAAAAAGAGGAGAAATCTTTAGCTAAGGATTTGGAAATAGCCGTTAAAAGAGCGGGTCATCTGCTTGACTCCAGTCAAAGTCTGCTGGAGATCACAGAACTTTATCTGGCTTTGAGCCGTCGTTTGGAAAAACTTTATGTTTATGCTTCTATGAAGAATGACCAAGACACCACGGTCAGTTACTATCAAGAATTACAAGCTAAGGCAACAGCCTTGATCGCTAAATTTAATCAGACTTTTGCCTTCTATGAGCCTGAATTTATGCTGTTATCAACAGAAAAATATCAGGATTTTTTGGCAGATTGTCCGGATTTATTGCCTTATCAACATTTTTTTGAAAAATTATTTAAACAAAAAAAGCATGTTCTTTCTCAAAAGGAAGAGGCACTTTTGGCTGAAGCCAGTGAAATTTTTGGTGCTGCTGGTGAAACCTTTGAAATTCTTGACAATGCCGATATTATCTTTCCTTGGGTAAAAGACGAGACAGGAGAAGAAGTTGAACTATCTCATGGTAATTTCATCAGTTTGATGGAATCCAAAAACCGCAAAGTTCGACAAGAAGCTTATAAGGCCATGTACAGCATTTATGAGCAGTATCAACACACCTATGCTAAAACGCTGCAAACCAATGTTAAAGTTAATAATTTTCAAGCGAAAATCAGAAACTATAAGAGTGCGCGTGAAGCTGCTCTGGCAGCTAATTTTATTCCCGAAACTGTTTATGACACTTTAGTAGAAGCGGTCCATAATCACTTACCTTTGTTACAGCGTTATGTGAAGCTAAGGCAAAACGTTTTAGGCCTTGATGATCTTAAGATGTATGATATTTACGTACCACTCTCAGAAATGGATATGACTTTTACTTATGAAGCAGCCTTGGACAAAGCAGAAGAAGTGTTAGCTATTTTTGGGCGAGACTATGCTGAGCGTGTGCATCGTGCATTTAGGGAGCGTTGGATTGATGTACGAGTCAATAAAGGCAAGCGTTCAGGCGCTTATTCAGGTGGTTCCTATGACACCAATGCTTTTATATTGCTTAACTGGCAGGATACTTTGGATAACCTCTTCACTCTTGTGCATGAAACAGGACATTCTTTGCATTCTACTTTTACACGTGAAAACCAACCCTATGTTTATGGTGATTATTCTATTTTTCTGGCAGAAATTGCTTCGACAACCAATGAAAATATTTTGACAGAGACACTGCTCAAGGAAGCAACAGATGAGAAACAGCGTTTTGCGATTTTGAATCATTATCTTGATGGTTTCAAAGGAACGGTTTTCCGCCAAACACAATTTGCAGAATTTGAAGACTTGATTTATAAGGCTGATCAAGCAGGTGACGTTTTGACCAGTGATTATTTGAATAATCTCTATGCGGATCTCAATGAAAAATACTATGGTTTAAGTAAGGAAAATAATCCGGAAATTCAGTATGAATGGGCTAGAATTCCGCATTTTTACTACAATTTTTATGTCTATCAGTACGCTACAGGCTTTGCTGCAGCTAGTTTTTTGGCTCACAAAATTGTTCATGGCAATCAAGAAGATAAGGACAAATATCTCAATTATCTTAAAGCTGGCAATTCAGACTATCCTCTCAATGTTATTGCTAAAGCAGGTCTTGATATGACTGAGTCGACCTATCTTGATCAAGCCTTCAAAGTCTTTGAAGAACGGTTAATAGAGTTGGAAGAGTTGGTCGAAAAAGGAATTGATTAA","4.80","-28.11","69715","MSDNRSHIEEKYQWDLTSIFPNDQTWEKEEKSLAKDLEIAVKRAGHLLDSSQSLLEITELYLALSRRLEKLYVYASMKNDQDTTVSYYQELQAKATALIAKFNQTFAFYEPEFMLLSTEKYQDFLADCPDLLPYQHFFEKLFKQKKHVLSQKEEALLAEASEIFGAAGETFEILDNADIIFPWVKDETGEEVELSHGNFISLMESKNRKVRQEAYKAMYSIYEQYQHTYAKTLQTNVKVNNFQAKIRNYKSAREAALAANFIPETVYDTLVEAVHNHLPLLQRYVKLRQNVLGLDDLKMYDIYVPLSEMDMTFTYEAALDKAEEVLAIFGRDYAERVHRAFRERWIDVRVNKGKRSGAYSGGSYDTNAFILLNWQDTLDNLFTLVHETGHSLHSTFTRENQPYVYGDYSIFLAEIASTTNENILTETLLKEATDEKQRFAILNHYLDGFKGTVFRQTQFAEFEDLIYKADQAGDVLTSDYLNNLYADLNEKYYGLSKENNPEIQYEWARIPHFYYNFYVYQYATGFAAASFLAHKIVHGNQEDKDKYLNYLKAGNSDYPLNVIAKAGLDMTESTYLDQAFKVFEERLIELEELVEKGID","605514","For other 'pep' genes see SMu0632 (pepT); SMu0649 (pepC);SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). From Genbank:[gi:6093668]This protein has oligopeptidase activity and degrades a variety of small bioactive peptides,including bradykinin,neurotensin,and peptide fragments of substance P and adrenocorticotropin.It also hydrolyzes the synthetic collagen-like substrate N-(3-[2-FURYL]ACRYLOYL)-LEU-GLY-PRO-ALA (FALGPA) .","PepB oligopeptidase","Cytoplasm, Extracellular","Several matches in gapped BLAST to oligopeptidase: residues 1-598are 72% similar to the enzyme in S.agalactiae (gi6093668) and are 70% similar to the protein from S.pyogenes (gi15675317).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0805 (0.0).","

InterPro
IPR000871
Family

Beta-lactamase, class A
PS00146	$\"[113-128]?$	BETA_LACTAMASE_A

InterPro
IPR001567
Domain

Peptidase M3A and M3B, thimet/oligopeptidase F
PF01432	$\"[201-582]T$	Peptidase_M3

InterPro
IPR004438
Family

Peptidase M3B, oligoendopeptidase F
TIGR00181	$\"[5-593]T$	pepF

InterPro
IPR013647
Domain

Peptidase M3B, oligopeptidase F, N-terminal
PF08439	$\"[112-181]T$	Peptidase_M3_N

noIPR
unintegrated

unintegrated
SSF55486	$\"[52-596]T$	SSF55486

","BeTs to 7 clades of COG1164COG name: Oligoendopeptidase FFunctional Class: EThe phylogenetic pattern of COG1164 is ------v--B--ujgpolin-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 116-494 are 74% similar to a (OLIGOENDOPEPTIDASE PROTEOME COMPLETE) protein domain (PD005933) which is seen in PEPB_STRAG.Residues 88-150 are 30% similar to a (PROTEOME OLIGOPEPTIDASE COMPLETE) protein domain (PD235227) which is seen in Q9HNP8_HALN1.Residues 5-82 are 69% similar to a (COMPLETE OLIGOENDOPEPTIDASE PROTEOME F) protein domain (PD011858) which is seen in PEPB_STRAG.Residues 503-583 are 79% similar to a (OLIGOENDOPEPTIDASE COMPLETE PROTEOME) protein domain (PD223872) which is seen in PEPB_STRAG.Residues 452-582 are 30% similar to a (METALLOPROTEASE PROTEOME) protein domain (PD143486) which is seen in Q9PR80_UREPA.Residues 116-176 are 49% similar to a (F OLIGOENDOPEPTIDASE CHROMOSOMAL) protein domain (PD264288) which is seen in PEF2_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 09:17:17 2006","Fri Oct 11 12:51:18 2002","Tue Aug 1 09:17:17 2006","Wed Dec 12 13:45:14 2001","","Wed Dec 12 13:45:14 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0587 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 13:45:29 2001","","No significant hits to the NCBI PDB database.","SMU.645","","Residues 201 to 582 (E-value = 3.5e-151) place SMu0587 in the Peptidase_M3 family which is described as Peptidase family M3 (PF01432)","Wed Dec 12 13:45:14 2001","24379118","","","Lin,B., Averett,W.F., Novak,J., Chatham,W.W., Hollingshead,S.K.,Coligan,J.E., Egan,M.L. and Pritchard,D.G.Characterization of PepB, a group B streptococcal oligopeptidaseInfect. Immun. 64 (8), 3401-3406 (1996)PubMed: 8757883","","Wed Dec 12 13:50:52 2001","1","","","SMU.645","86" "SMu0588","605730","606347","618","ATGCCACAAACAGCTTTTATTTGGGATTTGGATGGAACACTGATTGATTCTTATGAGGCCATTATGGAGGCTCTTGCGGTCACTTATAGGACTTTTGGTTTTGATTTTCAAGCAGAGCCTATTCGACGTTATATTATCAAAGAATCGGTTGGGAAACTCTTAGACATACTGGCGAAACAGCACGGCCTTTCTTCTGAAGAATTAAAAACTTTCTTCATCCAAGAGCAAGTTAAGCGTGATGATAAGATTAAGTTGATGCCCTTTGCCAAAGAAGCGCTGCAGTGGGCCAAAGACAGAGGAATTAAGCAATTTATGTATACCCATAAAGGTGCCTCTACTGGAGCGGTGCTGGCAGAATTAGGAATTGTCTCTTATTTTACTGAAATATTGACAAGTGTGTCGGGATTTGAACGCAAACCACATCCACAGGGAATCTTTTATCTGCTGGAGAAATATCATTTGGATAGAGACAGAACTTACTATATTGGCGATAGACGTCTAGATGTAGAAGTTGCTGAAAATGCAGGCATCAAATCTATTAATCTAGCCCAGCCCCAGTCAGCTGCTAATCAGAAAATTGATAATCTACAAGTCTTGACTCAGCTGAAAGATTTCTAA","6.50","-1.03","23488","MPQTAFIWDLDGTLIDSYEAIMEALAVTYRTFGFDFQAEPIRRYIIKESVGKLLDILAKQHGLSSEELKTFFIQEQVKRDDKIKLMPFAKEALQWAKDRGIKQFMYTHKGASTGAVLAELGIVSYFTEILTSVSGFERKPHPQGIFYLLEKYHLDRDRTYYIGDRRLDVEVAENAGIKSINLAQPQSAANQKIDNLQVLTQLKDF","606344","","hydrolase (possible phosphoglycolate phosphatase)","Cytoplasm","Matches in gapped BLAST to hydrolase, haloacid dehalogenase-like family proteins: residues 1-202 are 48% similar to the enzyme in S.pneumoniae (gi15901883).Residues 6-177 are 29% similar to phosphoglycolate phosphatase in S.pneumoniae R6 (gi15902758). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0806 (7e-64).","

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[3-185]T$	Hydrolase

InterPro
IPR006439
Family

HAD-superfamily hydrolase, subfamily IA, variant 1
TIGR01549	$\"[5-176]T$	HAD-SF-IA-v1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[72-182]T$	G3DSA:3.40.50.1000
PTHR18901	$\"[1-185]T$	PTHR18901
SSF56784	$\"[1-205]T$	SSF56784

","BeTs to 7 clades of COG0546COG name: Predicted phosphatasesFunctional Class: RThe phylogenetic pattern of COG0546 is a-TkyQ-CEBRhuj--oL---Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 6-138 are 42% similar to a (PROTEOME COMPLETE YJCF YSBA) protein domain (PD415277) which is seen in Q9CET1_LACLA.Residues 139-180 are 66% similar to a (COMPLETE PROTEOME) protein domain (PD202150) which is seen in Q9CET1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 18 08:56:35 2002","Fri Oct 11 12:53:32 2002","Fri Mar 16 11:44:49 2007","Wed Dec 12 14:11:52 2001","","Wed Dec 12 14:11:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0588 is paralogously related (blast p-value < 1e-3) to SMu1168, a predicted phosphoglycolate phosphatase.","Wed Feb 27 11:22:34 2002","","No significant hits to the NCBI PDB database.","SMU.646","","Residues 3 to 185 (E-value = 2.6e-22) place SMu0588 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Wed Dec 12 14:11:52 2001","24379119","","","","","","1","","","SMU.646","" "SMu0589","606397","607104","708","ATGGTTAAATCTTACAGTAAAAATGCAAATCACAACATGCGACGTCCTGTTATTAAGGAAGACATTCTTCACTACATGCGTCATGAGCAAAAGGAAAATATGGGCTTTTTAAAGGAACTGGAAATATTTGCTCATGAGGAGAATATTCCAATCATTCCCCAAGAAACTGTTGTGTATTTTCGTTTTCTTTTGCAGACTTTTCAGCCTAAGAATATCTTAGAAATTGGGACGGCTATTGGTTTTTCAGCACTTTTGATGGCTGAGAATGCTCCACAAGCAAATATTACGACCATTGACCGTAATCCTGAAATGATTGCTCTAGCCAAGGAAAACTTTGCAAAATATGATAGTCGAAAGCAGATTAACTTGCTAGAAGGAGATGCTGCCAATATTTTAACTAAACTGAATGGGAATTACGATTTCGTTTTTATGGATTCAGCAAAGTCAAAATATATTGTTTTTTTACCAACTGTTCTAGAGTGTTTAGAGATTGGCGGTATCGTTGTTTTAGATGATGTTTTTCAAGGCGGTGATATTGCTAAGCCAATTGAAGAAGTTCATCGCGGCCAGCGTACCATTTATCGTGGTTTGCAAAAGCTATTTGACGCAACACTGAAACATCCTGATTTGACTGTCAGTTTGCTGCCGCTTGGTGATGGTCTGCTGCTGATTCGTAAAAACCGCAAAGAGATTGGTTTGATTGATTAA","6.50","-1.59","26756","MVKSYSKNANHNMRRPVIKEDILHYMRHEQKENMGFLKELEIFAHEENIPIIPQETVVYFRFLLQTFQPKNILEIGTAIGFSALLMAENAPQANITTIDRNPEMIALAKENFAKYDSRKQINLLEGDAANILTKLNGNYDFVFMDSAKSKYIVFLPTVLECLEIGGIVVLDDVFQGGDIAKPIEEVHRGQRTIYRGLQKLFDATLKHPDLTVSLLPLGDGLLLIRKNRKEIGLID","607101","","O-methyltransferase","Cytoplasm","Several matches in gapped BLAST to methyltransferase: residues 1-235 are 71% similar to the enzyme in S.pyogenes (gi15675315).Residues 1-233 are 71% similar to the protein from S.pneumoniae(gi15900857).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0807 (3e-95).","

InterPro
IPR002935
Family

O-methyltransferase, family 3
PTHR10509	$\"[11-227]T$	Methyltransf_3

InterPro
IPR013216
Domain

Methyltransferase type 11
PF08241	$\"[73-170]T$	Methyltransf_11

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[14-215]T$	G3DSA:3.40.50.150
PIRSF005841	$\"[18-228]T$	Caff-CoA_3-mtase
SSF53335	$\"[13-230]T$	SSF53335

","BeTs to 9 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","***** IPB002935 (O-methyltransferase (family 3)) with a combined E-value of 1.3e-26. IPB002935A 50-97 IPB002935B 137-155 IPB002935C 193-226","Residues 63-177 are 29% similar to a (O-METHYLTRANSFERASE CATECHOL FORM SOLUBLE) protein domain (PD036521) which is seen in COMT_HUMAN.Residues 137-213 are 53% similar to a (METHYLTRANSFERASE CAFFEOYL-COA) protein domain (PD002853) which is seen in Q9CEV8_LACLA.Residues 69-127 are 74% similar to a (COMPLETE PROTEOME METHYLTRANSFERASE) protein domain (PD016907) which is seen in P94877_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 12:55:06 2002","Tue Aug 29 17:01:30 2006","Tue Aug 29 17:01:30 2006","Wed Dec 12 14:13:40 2001","Wed Dec 12 14:13:40 2001","Wed Dec 12 14:13:40 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0589 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 14:17:31 2001","","No significant hits to the NCBI PDB database.","SMU.647","","Residues 27 to 227 (E-value = 6e-14) place SMu0589 in the Methyltransf_3 family which is described as O-methyltransferase (PF01596)","Wed Dec 12 14:13:40 2001","24379120","","","","","","1","","","SMU.647","547" "SMu0590","607166","608167","1002","ATGAAAAAACGTACGATTGCTACAGGACTTGTGACTTTGCTTTCTATTGTGACTTTAGCGGCTTGTTCAAAAACAAACCAAAACAGTAAAATTGCTACAATGAAGGGTGATACTATTACTGTTGCAGATTTTTATAATGAAGTAAAGAATTCAACAGCTTCTAAGCAGGCTGTATTATCTCTCTTAGTTTCAAAAGTTTTTGAAAAACAATACGGCGATAAGGTTTCTGATAAGGAAGTGACAAAAGCTTATAATGAAGCTGCTAAGTACTATGGTGATTCTTTCTCAAGTGCTTTGGCTTCACGCGGCTACACAAAAGAAGATTATAAGAAACAAATTCGTTCTGAAAAATTAATAGAATATGCTGTTAAGGAAGAAGCTAAGAAAGAAATAACAGACGCTAGTTATAAGTCAGCTTATAAGGATTATAAACCGGAAGTAACAGCTCAAGTGATTCAATTGGATAGTGAAGATAAGGCAAAATCTGTTTTAGAAGAAGCTAAGGCAGATGGTGCAGACTTTGCTAAAATTGCTAAAGATAATACCAAAGGAGATAAGACCGAATATAGCTTTGATTCAGGCTCAACTAATCTTCCTAGTCAAGTTTTATCGGCTGCTTTGAATCTTGATAAGGATGGCGTTTCAGATGTCATTAAGGCGTCTGATTCAACGACTTATAAACCTGTTTACTATATTGTCAAAATCACGAAAAAGACTGACAAAAACGCCGATTGGAAAGCTTATAAGAAACGTCTGAAAGAAATTATCGTTTCTCAAAAATTAAATGACAGTAATTTCCGTAATGCTGTTATTGGAAAAGCCTTTAAGAAAGCTAATGTCAAAATTAAAGATAAGGCCTTTAGTGAGATCTTATCACAATATGCAGCAGCAAGCGGAAGTGGCTCTTCAGGGTCAACGACGACTACAACAGCCGCTTCAAGCGCTGCAACAACAGCCGCTGATGATCAAACAACAGCAGCAGAGACAACAGCAGCGGAATAA","9.90","8.97","36079","MKKRTIATGLVTLLSIVTLAACSKTNQNSKIATMKGDTITVADFYNEVKNSTASKQAVLSLLVSKVFEKQYGDKVSDKEVTKAYNEAAKYYGDSFSSALASRGYTKEDYKKQIRSEKLIEYAVKEEAKKEITDASYKSAYKDYKPEVTAQVIQLDSEDKAKSVLEEAKADGADFAKIAKDNTKGDKTEYSFDSGSTNLPSQVLSAALNLDKDGVSDVIKASDSTTYKPVYYIVKITKKTDKNADWKAYKKRLKEIIVSQKLNDSNFRNAVIGKAFKKANVKIKDKAFSEILSQYAAASGSGSSGSTTTTTAASSAATTAADDQTTAAETTAAE","608164","For other 'ppm' genes see SMu1128 (ppm).For other 'prt' genes see SMu1312 (prtB).","protease maturation protein; possible peptidylprolyl isomerase","Extracellular, Periplasm, Membrane","Limited matches in gapped BLAST to protease maturation protein: residues 6-294 are 56% similar to the protein in S.pyogenes (gi15675314).Residues 1-294 are 50% similar to the protein from S.pneumoniae (gi15902928).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0808 (1e-104).","

noIPR
unintegrated

unintegrated
PS51257	$\"[1-22]T$	PROKAR_LIPOPROTEIN
SSF54534	$\"[115-237]T$	SSF54534
SSF81827	$\"[28-146]T$	SSF81827

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 22-145 are 38% similar to a (PRECURSOR LIPOPROTEIN MATURATION SIGNAL) protein domain (PD021067) which is seen in Q9CEV9_LACLA.Residues 146-290 are 38% similar to a (PROTEOME COMPLETE MATURATION) protein domain (PD397800) which is seen in Q9CEV9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jul 28 11:14:51 2006","Fri Jul 28 11:14:51 2006","Fri Jul 28 11:10:23 2006","Wed Dec 12 14:18:42 2001","","Wed Dec 12 14:18:42 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0590 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 14:19:09 2001","","No significant hits to the NCBI PDB database.","SMU.648","","No significant hits to the Pfam 11.0 database","Wed Dec 12 14:18:42 2001","24379121","","","Drouault S, Anba J, Bonneau S, Bolotin A, Ehrlich SD, Renault P. The peptidyl-prolyl isomerase motif is lacking in PmpA, the PrsA-like protein involved in the secretion machinery of Lactococcus lactis.Appl Environ Microbiol. 2002 Aug;68(8):3932-42.PMID: 12147493 ","","Sat Oct 26 16:18:14 2002","1","","","SMU.648","666" "SMu0591","608406","608906","501","ATGAAGAGTTTTCAAATCAAACAAAAAATGTGGTCGCCAGGCGGTAAATTTACCATTACAGATGAGCTAGGAATCCCAACTTATCAAGTAGAGGGCTCCATCTTTAAAATTCCAAAGACATTTATCATTTCGGATATGCAGGGTAAACAGATCAGCCGTATCCAAAGGAAAACTTGGACCTTCCTTCCTAAGTTTTATGTCAATTTACACGATGGTTCTACATTTTTCCTGAAAAGAGATCTGTCATTTTTTAAACCTCACTATACAATTAAAGATTTAGACATGGAAATTCAAGGTGATTTTTGGGATATGAATTTTCGGCTCCTCCAAAATGATCAGGAAGTTGCTAGTATTTCTCAGGAATGGCTGCGCCTGACCTCGACTTATAATATTGAAGTATATGATGATCAATATACAGACTTAGTGATATCACTGGTCATTGCTATTGACTATGTCAAGGCGATTGAAAAAAGCTCTGCAAGATCATCGGCATCACATTAA","7.80","0.71","19442","MKSFQIKQKMWSPGGKFTITDELGIPTYQVEGSIFKIPKTFIISDMQGKQISRIQRKTWTFLPKFYVNLHDGSTFFLKRDLSFFKPHYTIKDLDMEIQGDFWDMNFRLLQNDQEVASISQEWLRLTSTYNIEVYDDQYTDLVISLVIAIDYVKAIEKSSARSSASH","608903","","conserved hypothetical protein","Membrane, Cytoplasm","Limited hits in gapped BLAST to conserved hypothetical protein:residues 1-159 are 48% similar to this protein from S.pneumoniae (gi|15903284|).Residues 6-152 are 27% similar to gi|7452125| from B.subtilis The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0809 (3e-55).","

InterPro
IPR007612
Family

Protein of unknown function DUF567
PF04525	$\"[3-148]T$	DUF567

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 9-152 are 26% similar to a (PROTEOME COMPLETE) protein domain (PD095268) which is seen in P94352_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 11:14:58 2002","Wed Dec 12 15:17:11 2001","Tue Mar 19 11:14:58 2002","Wed Dec 12 15:17:11 2001","","Wed Dec 12 15:17:11 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0591 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 18 08:58:25 2002","","No significant hits to the NCBI PDB database.","SMU.649","","Residues 3 to 148 (E-value = 7e-17) place SMu0591 in the DUF567 family which is described as Protein of unknown function (DUF567) (PF04525)","Wed Dec 12 15:17:11 2001","24379122","","","","","","1","","","SMU.649","" "SMu0592","609121","611739","2619","ATGAAACAATTAACATCAGCTCAAGTCCGCCAAATGTGGTTAGATTTTTGGAAATCAAAGGATCATGCTATCGAGCCGTCGGCTAATCTCGTCCCTGTTAATGATCCCACACTGCTGTGGATTAATTCAGGTGTCGCAACGCTGAAAAAATATTTTGATGGTTCTGTTATTCCTGAAAACCCACGCATTACCAATGCGCAAAAGGCCATCCGCACTAATGATATTGAAAATGTTGGAAAAACAGCTCGCCATCATACTATGTTTGAGATGCTGGGAAATTTTTCCGTTGGAGATTACTTCCGTGATGATGCTATCAAATGGGGCTTTGAACTTTTGACTAGTCCTGAATGGTTTGACTTACCAAAAGATAAGCTCTATATGACCTACTATCCAGATGATAAGGATTCTTACAATCGCTGGATTGAATGCGGTGTTGACCCAAGTCACCTGATTCCTATTGAAGATAACTTCTGGGAAATTGGCGCTGGGCCTTCAGGACCAGACACAGAAATTTTCTTTGATCGTGGAGAAGATTTTGATCCAGACCATATTGGTGTGCGCCTCTTGGCCGAGGATATTGAAAACGATCGCTACATTGAAATTTGGAATATCGTGCTTTCGCAATTCAATGCTGATCCAGCTGTTCCTCGTTCTGAATACAAGGAATTGCCTCATAAAAACATTGATACGGGTGCTGGCTTAGAGCGCTTGGTTGCGGTTATGCAAGGGGCAAAAACTAATTTTGAAACGGATCTTTTCATGCCAATCATCCGTGAGATTGAAAAACTATCTGGTAAAACGTATGACCAAGATGGCGACAATATGAGCTTCAAGGTCATTGCAGACCATATTCGTTCTCTCTCATTTGCTATTGGTGATGGTGCCCTTCCGGGAAATGAAGGCCGTGGTTATGTCCTTCGCCGTCTCCTTCGTCGTGCAGTTATGCACGGCCGTCGTTTAGGCATCAATGAACCCTTCTTGTATAAATTGGTTCCAACTGTTGGTAAGATTATGGAATCCTACTATCCAGAAGTGCTTGAAAAACAAGATTTTATTGAAAAAATTGTCAAACGTGAAGAAGAGACCTTTGCACGGACCATTGATGCGGGCTCAAACATGTTAGATCAACTTTTGGCTGATTTGAAGGCTGCTGATAAAGATACGCTTGAAGGAAAAGATATTTTCAGACTTTATGACACTTATGGCTTCCCAGTAGAATTGACCGAAGAATTGGCAGAGGATGCAGGCTTCAAGATAGATCATCAAGGCTTCCAAGCTGCTATGAAAGAACAACAAGAACGTGCGCGTGCCAATGTTGTCAAAGGCGGCTCCATGGGTATGCAAAATGAAACTCTGTCAAACATTACCGAAAAATCTACTTTCAATTATGAAAAAGAAGCACTTGACAGCAGTCTTTCTGTTATCATTGCTGACAATAAGCGTATAGAAGCAGTATCAGAAGGCCAAGTTCTGCTTGTTTTTTCGGAGACACCATTCTATGCTGAAATGGGTGGACAAGTAGCTGACCATGGGCTTATCAAGAATGATAAGGGAGACACTGTTGCTCGTGTGACAGATGTGCAAAAAGCGCCAAATGGTCAAGCCCTTCATACAGTTGATGTTTTGGGCAGCTTGTCAGTAGGGACAACTTATCATCTAGAAATTGATCATGAACGTCGCAACCGGGTCATGAAAAATCATACGGCTACTCATCTTCTTCATGCGGCGCTGCACAATGTCATTGGCAATCACGCCACTCAGGCAGGTTCTCTAAATGAAGTGGAATTCTTGCGCTTTGACTTTACCCATTTTGAAGCGGTAACGCCAGAAGAGCTCCGTCAAATTGAAGAAGAAGTCAACCAACAAATCTGGAAGGCTATTCCTGTGACAACCATTGAAACAGACCTTGATACCGCCAAGGAAATGGGTGCCATGGCTCTCTTTGGTGAAAAATACGGTAAAAATGTGCGTGTGGTTTCTATCGGCGACTATTCTGTTGAACTTTGTGGTGGGACCCATCTTAAAAATACTTCTGAAATTGGCATCTTCAAGATTGTCAAAGAAGAAGGTATTGGTTCAGGAACTCGCCGTATCCTAGCTGTGACCAGTAAGGAAGCCTTTGAAGCCTACCGCCAAGAAGAAGACATACTTAAAGAAATTGCCACAACGCTTAAAGCGCCTCAAATGAATCAGGTAGCCAACAAGGTAGCTTCGCTGCAAGACCAATTGCATAAATTGCAAAAGGAGAATGCCGAGCTGAAAGAAAAAGCAGCCGCAGTAGCCGCAGGCGATATCTTCAAAGATGTTAAAGAAGTGAATGGTCTTCGCTATATTGCGAGCCAAGTAGAAGTTGCCGATGCGGGTGCCCTTCGCACCTTTGCTGATAAATGGAAACAAAAAGATTACTCCGACGTTCTTGTTTTAGTGGCCAGCATTGGTAAAAAGGTCAATGTTCTTGTTGCCAGCAAGTCTAAGGATATCCATGCTGGTAATCTCATCAAGGCTTTGGCACCAATCGTTTCAGGTCGCGGTGGTGGAAAACCAGACATGGCCATGGCAGGTGGCTCAGATGCCTCAGCCATCAAAGATTTGATTGCCGCAGTAGCAGAGAATTTGTAA","5.10","-29.67","97158","MKQLTSAQVRQMWLDFWKSKDHAIEPSANLVPVNDPTLLWINSGVATLKKYFDGSVIPENPRITNAQKAIRTNDIENVGKTARHHTMFEMLGNFSVGDYFRDDAIKWGFELLTSPEWFDLPKDKLYMTYYPDDKDSYNRWIECGVDPSHLIPIEDNFWEIGAGPSGPDTEIFFDRGEDFDPDHIGVRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPHKNIDTGAGLERLVAVMQGAKTNFETDLFMPIIREIEKLSGKTYDQDGDNMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINEPFLYKLVPTVGKIMESYYPEVLEKQDFIEKIVKREEETFARTIDAGSNMLDQLLADLKAADKDTLEGKDIFRLYDTYGFPVELTEELAEDAGFKIDHQGFQAAMKEQQERARANVVKGGSMGMQNETLSNITEKSTFNYEKEALDSSLSVIIADNKRIEAVSEGQVLLVFSETPFYAEMGGQVADHGLIKNDKGDTVARVTDVQKAPNGQALHTVDVLGSLSVGTTYHLEIDHERRNRVMKNHTATHLLHAALHNVIGNHATQAGSLNEVEFLRFDFTHFEAVTPEELRQIEEEVNQQIWKAIPVTTIETDLDTAKEMGAMALFGEKYGKNVRVVSIGDYSVELCGGTHLKNTSEIGIFKIVKEEGIGSGTRRILAVTSKEAFEAYRQEEDILKEIATTLKAPQMNQVANKVASLQDQLHKLQKENAELKEKAAAVAAGDIFKDVKEVNGLRYIASQVEVADAGALRTFADKWKQKDYSDVLVLVASIGKKVNVLVASKSKDIHAGNLIKALAPIVSGRGGGKPDMAMAGGSDASAIKDLIAAVAENL","611736","","alanyl-tRNA synthetase (alanine--tRNA ligase)","Cytoplasm","Several matches in gapped BLAST to alanyl-tRNA synthetase: residues 1-870 are 80% similar to the enzyme in S.pyogenes (gi15675313).Residues 1-872 are 76% similar to the protein from S.pneumoniae (gi15903283).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0810 (0.0).","

InterPro
IPR002318
Family

Alanyl-tRNA synthetase, class IIc
PR00980	$\"[73-84]T$ $\"[199-210]T$ $\"[229-242]T$ $\"[278-294]T$ $\"[302-315]T$	TRNASYNTHALA
PF01411	$\"[8-559]T$	tRNA-synt_2c
TIGR00344	$\"[8-855]T$	alaS
PS50860	$\"[4-712]T$	AA_TRNA_LIGASE_II_ALA

InterPro
IPR003156
Domain

Phosphoesterase, DHHA1
PF02272	$\"[803-870]T$	DHHA1

InterPro
IPR012947
Domain

Threonyl/alanyl tRNA synthetase, SAD
PF07973	$\"[656-699]T$	tRNA_SAD

noIPR
unintegrated

unintegrated
PTHR11777	$\"[37-872]T$	PTHR11777
SSF101353	$\"[249-466]T$	SSF101353
SSF55186	$\"[555-723]T$	SSF55186
SSF55681	$\"[3-248]T$	SSF55681

","BeTs to 17 clades of COG0013COG name: Alanyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0013 is amtKYqVcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003156 (DHHA1 domain) with a combined E-value of 1.6e-165. IPB003156A 9-22 IPB003156B 71-101 IPB003156C 158-173 IPB003156D 196-211 IPB003156E 223-236 IPB003156F 279-316 IPB003156G 359-370 IPB003156H 397-408 IPB003156I 499-509 IPB003156J 567-620 IPB003156K 648-658 IPB003156L 664-681","Residues 560-699 are 69% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ALANYL-TRNA) protein domain (PD001534) which is seen in Q9CEW0_LACLA.Residues 1-262 are 81% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD002561) which is seen in Q9CEW0_LACLA.Residues 827-872 are 71% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD005722) which is seen in Q9CEW0_LACLA.Residues 276-420 are 71% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD002924) which is seen in Q9CEW0_LACLA.Residues 492-559 are 66% similar to a (SYNTHETASE LIGASE ALANYL-TRNA) protein domain (PD002754) which is seen in Q9CEW0_LACLA.Residues 700-857 are 24% similar to a (SYNTHETASE LIGASE ATP-BINDING ALARS) protein domain (PD204538) which is seen in SYA_RICPR.Residues 700-826 are 50% similar to a (SYNTHETASE PROTEOME COMPLETE ALANYL-TRNA) protein domain (PD396831) which is seen in Q9CEW0_LACLA.Residues 421-486 are 57% similar to a (SYNTHETASE PROTEOME COMPLETE ALANYL-TRNA) protein domain (PD388317) which is seen in Q9CEW0_LACLA.Residues 277-420 are 31% similar to a (SYNTHETASE LIGASE ATP-BINDING ALARS) protein domain (PD398964) which is seen in SYA_MYCGE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 12:59:35 2002","Wed Dec 12 15:18:28 2001","Tue Aug 1 09:29:59 2006","Wed Dec 12 15:18:28 2001","Wed Dec 12 15:18:28 2001","Wed Dec 12 15:18:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0592 is paralogously related (blast p-value < 1e-3) to SMu1441, a predicted threonyl-tRNA synthetase 1.","Fri Jan 18 09:00:01 2002","","No significant hits to the NCBI PDB database.","SMU.650","","Residues 803 to 870 (E-value = 4.9e-15) place SMu0592 in the DHHA1 family which is described as DHHA1 domain (PF02272)","Wed Dec 12 15:18:28 2001","24379123","","","Putney,S.D., Melendez,D.L. and Schimmel,P.R.Cloning, partial sequencing, and in vitro transcription of the gene for alanine tRNA synthetaseJ. Biol. Chem. 256 (1), 205-211 (1981)PubMed: 6256345Putney,S.D., Royal,N.J., Neuman de Vegvar,H., Herlihy,W.C.,Biemann,K. and Schimmel,P.Primary structure of a large aminoacyl-tRNA synthetaseScience 213 (4515), 1497-1501 (1981)PubMed: 7025207Romeo,T., Gong,M., Liu,M.Y. and Brun-Zinkernagel,A.M.Identification and molecular characterization of csrA, apleiotropic gene from Escherichia coli that affects glycogenbiosynthesis, gluconeogenesis, cell size, and surface propertiesJ. Bacteriol. 175 (15), 4744-4755 (1993)PubMed: 8393005Musier-Forsyth,K. and Schimmel,P.Acceptor helix interactions in a class II tRNA synthetase:photoaffinity cross-linking of an RNA miniduplex substrateBiochemistry 33 (3), 773-779 (1994)PubMed: 8292605","","Wed Dec 12 15:26:09 2001","1","","","SMU.650","87" "SMu0593","612979","611951","1029","ATGACAAAATATTCAACCCCAAATGCCCTCGGACTTGGACTTATTTTATTCATCATATCAGTGAGCTTGGTAGCCTGTTCAAAGTCCTCTACTTCGACATCTAAAAACTATAATGCTTCTGAAAAAGATTCTTATATCCTAAAAATTTCTGAAAACTCTGATCTTTGCGGCGCCCCCCAACAGATAGCTATTGAAAAAGGCTTTTTTGATGATGTTGGCTTGAAATACAAGGTTGTTAAAATCGGACAGGATACTTCTAATCTTGATGCTTTAAATGCTGGCAAGATTGATGCCTCTAACTCTTTGATGGCAAGTATTATTCAGCCTCTAGCTAATGGTGCTAAGCTAAAAATCACTACCGGCCTGCATACTGGCTGTCTGCAGATATTAACAAAAAATGGCAAAATCAAGTCTGCTGCCGAGCTAAAAGGGAAGAAGATCGGGGTAACTGCTGTTGCGGGCAGTCCCGCTATCTTTGCTAAACGTGTTCTGGCAAAATCTGGTTTAAAAGTCTCTGATGAGAAAGGTGATGTCAGTTTTGTTACTTACCAAAGCGATCAGTTAGGGCAGGTTCTGGACAAAGGCGAAGTTGATGCCATTGCCCTCGGTGATCCAGATACTGAAGTTCTGAAAAAACAATACGGCTTTAAAACATTAGCTAATTCATCAACTGACAAAGGTTTTAAAAACGAATATTGCTGTGTCGCTTATGTATCAAACGATATAGTCAAGAAACATCCAGCTGTTGCTGCTAAATATACTCTTGCCATGCAAAAAGCAGCCAATTGGGTGCAAAAGCACAAAGAAGAAACGGTTGATATTCAGTTAAATCAAAACTATGTTGCTGGCAGTAAAGACAGCAATCTTACCAGTCTAAACAGCTATACTTTTAAACCTAGCTATTCAGGTGCTTATGATAGCTTCGATACTGTAGCCAGCGACTTGCGAAAAATTGGTATTTTATCTAATGATGTTGACCTAAAAGCTTTAAGAATCAATTCCTTCTTAAAAGTGAAAAATGTTAAATAA","9.90","11.48","36709","MTKYSTPNALGLGLILFIISVSLVACSKSSTSTSKNYNASEKDSYILKISENSDLCGAPQQIAIEKGFFDDVGLKYKVVKIGQDTSNLDALNAGKIDASNSLMASIIQPLANGAKLKITTGLHTGCLQILTKNGKIKSAAELKGKKIGVTAVAGSPAIFAKRVLAKSGLKVSDEKGDVSFVTYQSDQLGQVLDKGEVDAIALGDPDTEVLKKQYGFKTLANSSTDKGFKNEYCCVAYVSNDIVKKHPAVAAKYTLAMQKAANWVQKHKEETVDIQLNQNYVAGSKDSNLTSLNSYTFKPSYSGAYDSFDTVASDLRKIGILSNDVDLKALRINSFLKVKNVK","611954","For other components see SMu0594 (NBD1) and SMu0595 (MSD1).","ABC transporter, periplasmic substrate-binding protein","Extracellular, Periplasm, Membrane","Matches in gapped BLAST to ABC transporter (binding lipoprotein) and to conserved hypotheticals: residues 58-274 are 27% similar to ABC transporter (binding lipoprotein) in Bacillus subtilis (gi|16077949|) and residues 47-336 are 23% similar to ABC transporter in Mesorhizobium loti gi|13475809| .SMu0593 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR015168
Domain

NMT1/THI5 like
PF09084	$\"[52-271]T$	NMT1

noIPR
unintegrated

unintegrated
PS51257	$\"[1-26]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[41-322]T$	SSF53850

","BeTs to 6 clades of COG0715COG name: Putative taurine-binding periplasmic proteinFunctional Class: PThe phylogenetic pattern of COG0715 is A---Y-VCEB-h------in-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 59-223 are 27% similar to a (PROTEOME LIPOPROTEIN COMPLETE PLASMID) protein domain (PD107491) which is seen in Q9ZH14_YERPE.Residues 58-274 are 27% similar to a (PROTEOME COMPLETE PERIPLASMIC PRECURSOR) protein domain (PD036706) which is seen in SSUA_BACSU.Residues 44-249 are 27% similar to a (PROTEOME COMPLETE PA3513) protein domain (PD299303) which is seen in Q9HY96_PSEAE.Residues 62-298 are 25% similar to a (BIOSYNTHESIS THIAMINE ENZYME PYRIMIDINE) protein domain (PD017866) which is seen in Y357_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 14:15:09 2002","Fri Jan 18 09:01:27 2002","Mon Oct 28 14:15:09 2002","Wed Dec 12 16:48:54 2001","","Wed Dec 12 16:48:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0593 is paralogously related (blast p-value < 1e-3) to SMu1112, a predicted ABC transporter (binding protein).","Fri Jan 18 09:01:27 2002","","No significant hits to the NCBI PDB database.","SMU.651c","","No significant hits to the Pfam 11.0 database","Wed Dec 12 16:48:54 2001","24379124","","","","","","1","","","SMU.651c","" "SMu0594","613748","612999","750","ATGGTAGGATTTCTCAGGATTAACCACGTTCAAAAGATCTTTAAAGCAACTGATGATGCGCATACAGAGATTGAGGCTCTGCATCAGATTAATACAGATATTGAACCCGGAGAATTTATTTCGCTTGTCGGCCCTTCAGGGAGCGGAAAAACAACTCTTCTGCGCATCATTGCAGGTCTGGAGAAAGCCAGTCAAGGTGAAGTTTGGCTGGATGATCAGATAATTAGCCAGCCCTCGCGAAAGCTCGGCTTTGTCTTTCAAGAAGCAACCCTTTATCCTTGGCTGACTGTTTATGATAATATCGCCCTAGGCCTAAAGTTGAATAAAGAAAAAGAACGTCTGGCAGAAGTTAAAGATTATATCAATTTAGTTGGACTGAGTGGTTTTGAAAAAGCCTATCCTCATAATCTATCTGGTGGTATGCAGCAACGGGTCAATATTGCTAGAGCATTGATTAATAATCCCGATGTCCTACTGCTTGATGAACCATTTGGCGCCTTAGACGCCTTTACCAGAAGCAAGATGCAGGCTGAGCTTATTGATATTTGGCAAAAACGCCAAATTACCATGATCATGGTAACTCATGATGTCGAAGAAGCTGTTTTTCTCTCTGACCGCGTGTTTGCCATGACACCAAGACCAGCTGTTATTAAGGAAAGTATTGCAGTTGACTTGAAAAGGCCAAGAGAAAGAGACTCTCAGAACTTTATTGCTATTAAGAAAAAGATCTTACACATATTGAACTTCTAA","6.80","-0.55","28149","MVGFLRINHVQKIFKATDDAHTEIEALHQINTDIEPGEFISLVGPSGSGKTTLLRIIAGLEKASQGEVWLDDQIISQPSRKLGFVFQEATLYPWLTVYDNIALGLKLNKEKERLAEVKDYINLVGLSGFEKAYPHNLSGGMQQRVNIARALINNPDVLLLDEPFGALDAFTRSKMQAELIDIWQKRQITMIMVTHDVEEAVFLSDRVFAMTPRPAVIKESIAVDLKRPRERDSQNFIAIKKKILHILNF","613002","For other components see SMu0595 (MSD1) and SMu0593 (SBP1).For other 'msm' genes see SMu0799 (msmR); SMu0801 (msmE); SMu0802 (msmF); SMu0803 (msmG); SMu0805 (msmK); SMu1079 (msmK); SMu1428 (msmK) and SMu0884 (msmK).","ABC transporter, ATP-binding protein (possible nitrate transport system)","Cytoplasm, Membrane","Residues 5-211 are 40% similar to ATP-binding protein, a previously published sequence in Genbank (gi153741),(gi282320) and (gi547928) from S.mutans.Several matches in gapped BLAST to ABC transporter, ATP-binding possible nitrate transport system: residues 24-247 are 50% similar to the protein in Pseudomonas aeruginosa (gi15595382).Residues 24-244 are 49% similar to the protein from Bacillus subtilis (gi16077948).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1111 (3e-43).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[136-179]T$	ABC_transporter
PF00005	$\"[37-213]T$	ABC_tran
PS00211	$\"[137-151]T$	ABC_TRANSPORTER_1
PS50893	$\"[5-237]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[36-215]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-240]T$	G3DSA:3.40.50.300
PTHR19222	$\"[5-248]T$	PTHR19222
PTHR19222:SF51	$\"[5-248]T$	PTHR19222:SF51
SSF52540	$\"[5-210]T$	SSF52540

","BeTs to 6 clades of COG1116COG name: ABC-type nitrate transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1116 is Am----VCEB-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 7e-35. IPB001140A 26-72 IPB001140B 134-172","Residues 180-225 are 50% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD351123) which is seen in NRTD_SYNY3.Residues 29-220 are 24% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 180-219 are 57% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Y412_METJA.Residues 81-207 are 29% similar to a (AS-48D PLASMID BACE) protein domain (PD034066) which is seen in O53027_ENTFA.Residues 83-134 are 55% similar to a (ATP-BINDING TRANSPORT TRANSPORTER) protein domain (PD052375) which is seen in Q9I6U9_PSEAE.Residues 78-134 are 45% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD257439) which is seen in Q9R6V2_SYNP7.Residues 30-77 are 50% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in UGPC_ECOLI.Residues 137-179 are 74% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9I1I1_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:43:15 2007","Fri Oct 11 13:02:22 2002","Tue Apr 24 10:43:15 2007","Wed Dec 12 17:40:54 2001","Wed Dec 12 17:40:54 2001","Wed Dec 12 17:40:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0594 is paralogously related (blast p-value < 1e-3) to SMu0884, SMu1920, SMu0805, SMu1428, SMu1079, SMu1003, SMu0971, SMu0418, SMu0916, SMu1288, SMu0786, SMu0517, SMu1380, SMu1762, SMu0731, SMu1751, SMu1210, SMu1246, SMu1231, SMu0218, SMu1068, SMu0390, SMu1950, SMu0235, SMu0849, SMu1036, SMu1001, SMu0335, SMu1517, SMu0216, SMu1949, SMu0596, SMu0234, SMu0944, SMu1518, SMu0950, SMu1023, SMu0824, SMu1649, SMu0258, SMu1757, SMu1410, SMu1710, SMu0825, SMu0374, SMu0024, SMu1316, SMu0976, SMu0752, SMu1037, SMu0987, SMu0164, SMu1811, SMu0475, SMu1724, SMu0836, SMu1065, SMu0907, SMu1064, SMu0986, SMu1306, SMu0837, SMu0823, SMu1545, SMu1093, SMu0476, SMu0224, SMu1050, SMu1959, SMu0666, and SMu0729 all with ATP-binding capabilities.","Tue Jan 15 11:00:05 2002","Tue Apr 24 10:43:15 2007","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 158 6e-040pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 100 2e-022","SMU.652c","","Residues 37 to 213 (E-value = 1.2e-63) place SMu0594 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Dec 12 17:40:54 2001","24379125","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 1537846Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:43:15 2007","","1","","","SMU.652c","" "SMu0595","614728","613742","987","ATGAGGAAAACAAAGAAAGGTGATGATTTTTTGGAGACTGCAAAAGACTACTATCGTTTATTTTTCGCTAGTTCTGCTATTTTGTTGACGATTTTAGCACAGCTTCTCATTCCTAAATCTGCCGTTAGTTTTACTAAAATCCAATCTTGGTATTTATATTTTCTCTGGATTTCTTTTGCTCTTTCGCTTGCAGCGGCCTTTTTTAGTATTGTACGCCACAAAAAAGGAAAATTTTATCACAAAAGCTATTTTATTGGTACCAGCTACTTGGCATTGGCCGTTTATAATTTTGTCACTGAAAAGTTGAGCTTACTACCTGAGATTTTCTTTCCCAGTCCCAATAAAATTCTGGCGGTCTTTGTCAAAAGTGGTCCTTTCATTCTAAAATGCGATCTCTTTTCACTGCGGTTACTAGCTATTTCGTGGGCTATCGGAATTGCTTTAGGCTTACTGACAGGTATTCTAGTTGGTTGGTTTACCTCCTTTAATTACTGGTTAGATCCAATTGTCAAAATTCTGGGACCGATTCCGTCCACAGCTTTTGTCCCTCTGGCCTTGACAGCTTTTCCTACAAGCTTTGCAGCCAGTATTTTTCTGATCAGTCTTTCTGTCTGGTTTCCTGTGACGATTTTAACCAACTCCGGCATTCAAAATGTCAAAAAAACTTATTTTGAAGTCGCAGATACTCTTGGAGCTACAACTTTTCAAAAGATTGCTCATGTTGCCCTTCCAGCTAGCCTGCCCAATGTTTTTGTCGGTATTTTCAATGGCGCCTGTACCAGTTTTATCACCTTGATGACAGCAGAAATGCTGGGCGTTAAATACGGTATTGGCTGGTATATCAACTGGCAGAGGGAAGTCTTAGGCTATGCTAATGTCTATGCTGGTTTGATTACTATCGCTGTTACTTTTAGCTTGATTATTACACTTCTTTTCAAGGTTCGTGATAGATTGCTCTCATGGCAGAAAGGATTTATTAAATGGTAG","10.60","16.61","36764","MRKTKKGDDFLETAKDYYRLFFASSAILLTILAQLLIPKSAVSFTKIQSWYLYFLWISFALSLAAAFFSIVRHKKGKFYHKSYFIGTSYLALAVYNFVTEKLSLLPEIFFPSPNKILAVFVKSGPFILKCDLFSLRLLAISWAIGIALGLLTGILVGWFTSFNYWLDPIVKILGPIPSTAFVPLALTAFPTSFAASIFLISLSVWFPVTILTNSGIQNVKKTYFEVADTLGATTFQKIAHVALPASLPNVFVGIFNGACTSFITLMTAEMLGVKYGIGWYINWQREVLGYANVYAGLITIAVTFSLIITLLFKVRDRLLSWQKGFIKW","613745","For other components see SMu0594 (NBD1) and SMu0593 (SBP1).","ABC transporter, permease protein (possible taurine transport system permease)","Membrane, Cytoplasm","Several matches in gapped BLAST to ABC transporter permease / taurine transport system permease protein: residues 163-324 are 34% similar to the enzyme in Yersinia pestis (gi|16122511|).Residues 85-321 are 26% similar to taurine transport system permease protein from E.coli (gi|15800097|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1796 (2e-06).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[134-321]T$	BPD_transp_1
PS50928	$\"[131-312]T$	ABC_TM1

","BeTs to 7 clades of COG0600COG name: Uncharacterized permeasesFunctional Class: RThe phylogenetic pattern of COG0600 is Am-k--VCEB-h--gpo-in-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 207-278 are 40% similar to a (TRANSPORT PERMEASE COMPLETE TRANSMEMBRANE) protein domain (PD001159) which is seen in SSUC_BACSU.Residues 166-259 are 31% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD400838) which is seen in Q50446_MYCSM.Residues 166-254 are 33% similar to a (MEMBRANE PROTEOME COMPONENT SYSTEM) protein domain (PD414592) which is seen in Q9KYY5_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 10:20:28 2002","Tue Oct 29 10:35:13 2002","Mon Oct 28 10:20:28 2002","Wed Dec 12 17:47:14 2001","","Wed Dec 12 17:47:14 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0595 is paralogously related (blast p-value < 1e-3) to SMu0970,a predicted glycine-betaine binding permease protein, SMu1921 and SMu1923,both predicted glycine betaine / carnitine / choline ABC transporter permease, SMu1002,a predicted ABC transporter membrane-spanning permease - choline,SMu1038, and SMu0516, a predicted phosphate ABC transporter (permease protein).","Tue Jan 29 16:28:05 2002","","No significant hits to the NCBI PDB database.","SMU.653c","","Residues 134 to 321 (E-value = 1.8e-15) place SMu0595 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Dec 12 17:47:14 2001","24379126","","","","","","1","","","SMU.653c","" "SMu0596","614935","615639","705","GTGATAGATTATATGCTAGAGACGAAAAATTTAACTAAACAGTTTGGTAAGCAAACAGCGGTTAACCAATTGAATTTGAAAGTTGAACGTCATTCAATTTATGGTTTGCTGGGGCCTAATGGTTCCGGCAAATCAACAACACTTAAAATGATTACTGGAATGCTAAGAAAGACATCTGGTCACATTCTTATAGACGGACACGATTGGAGCCGCAAGGATTTAGAAAATATCGGGGCTCTGATTGAATCACCGCCGCTTTATGAAAACCTGACTGCGCATGAAAATTTAAAGGTAAGAACCTTGATGCTGGGTTTACCTGATAGTCGCATTGATGAGGTTTTAAAAATAGTGGATCTAACCAACACGGGTAAAAAAAGAGCAGGGCAATTTTCTATGGGCATGAAGCAGCGTCTGGGTATTGCTATCGCACTTTTGAACTCACCTCAACTTTTGATTCTGGATGAACCGACTAATGGACTTGATCCTATTGGTATTCAGGAGTTGCGTAATCTTATTCGTTCCTTCCCTACACAAGGAATTACAGTTATTATTTCCAGTCATATCTTATCTGAGATTCAGATGACAGCGGATCATATTGGTATCATTGCTAATGGCGTACTGGGTTATCAGGATAGAATTCACCAAGATGAAGACTTGGAAAAACTCTTTACAGAGGTTGTGATGAAATATCGAGGAGGTGAGTGA","7.30","0.69","26006","MIDYMLETKNLTKQFGKQTAVNQLNLKVERHSIYGLLGPNGSGKSTTLKMITGMLRKTSGHILIDGHDWSRKDLENIGALIESPPLYENLTAHENLKVRTLMLGLPDSRIDEVLKIVDLTNTGKKRAGQFSMGMKQRLGIAIALLNSPQLLILDEPTNGLDPIGIQELRNLIRSFPTQGITVIISSHILSEIQMTADHIGIIANGVLGYQDRIHQDEDLEKLFTEVVMKYRGGE","615636","For other components see SMu0598 (MSD1) and SMu0599 (MSD2).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to MutF and to other ABC transporters: residues 2-234 are 98% similar to the protein in S.mutans (gi9802352).Residues 5-228 are 53% similar to ABC transporter (ATP-binding) - lantibiotic associated in S.pyogenes (gi15675073).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1980 (3e-36).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[129-172]T$	Q9FDH4_STRMU_Q9FDH4;
PF00005	$\"[31-205]T$	ABC_tran
PS50893	$\"[6-229]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-206]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-230]T$	no description
PTHR19222	$\"[6-213]T$	ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF16	$\"[6-213]T$	ABC TRANSPORTER

","BeTs to 10 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.7e-27. IPB001140A 20-66 IPB001140B 127-165 IPB001140C 181-210","Residues 173-226 are 98% similar to a (ATP-BINDING TRANSPORTER COMPLETE PROTEOME) protein domain (PD000174) which is seen in Q9FDH4_STRMU.Residues 11-205 are 23% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 125-205 are 34% similar to a (ABC TRANSPORTER) protein domain (PD058053) which is seen in O69995_STRCO.Residues 77-128 are 98% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD342138) which is seen in Q9FDH4_STRMU.Residues 75-172 are 30% similar to a (COSMID C56E6 CG11069) protein domain (PD145750) which is seen in Q9VC15_DROME.Residues 86-207 are 27% similar to a (LACF) protein domain (PD194047) which is seen in Q9RAV2_LACLA.Residues 5-74 are 34% similar to a (PROTEOME COMPLETE PM1309) protein domain (PD390268) which is seen in Q9CLC9_PASMU.Residues 21-69 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9FDH4_STRMU.Residues 129-172 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9FDH4_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:11:22 2005","Tue May 3 12:11:22 2005","Tue May 3 12:11:22 2005","Wed Dec 12 17:55:04 2001","Wed Dec 12 17:55:04 2001","Wed Dec 12 17:55:04 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0596 is paralogously related (blast p-value < 1e-3) to SMu1649, SMu0944, SMu1050, SMu0216, SMu0335, SMu0390, SMu0950, SMu0976, SMu0374, SMu1380, SMu1093, SMu1003, SMu0849, SMu0218, SMu1518, SMu1950, SMu1023, SMu0731, SMu1079, SMu0884, SMu1920, SMu0666, SMu1410, SMu0517, SMu1517, SMu0418, SMu1210, SMu1762, SMu0594, SMu1288, SMu1428, SMu1037, SMu0805, SMu0164, SMu1949, SMu0971, SMu1246, SMu1231, SMu0907, SMu0916, SMu0476, SMu1068, SMu0235, SMu1751, SMu1036, SMu0786, SMu1316, SMu1064, SMu0752, SMu1545, SMu1001, SMu0825, SMu1306, SMu1959, SMu1757, SMu0836, SMu1065, SMu0986, SMu0234, SMu1710, SMu1724, SMu0824, SMu0258, SMu1811, SMu0837, SMu0823, SMu0987, SMu0024, SMu0224, SMu0475, SMu1202, SMu1686, and SMu0729, all with ATP-binding capabilities.","Tue Mar 19 12:44:18 2002","Tue May 3 12:11:22 2005","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 98 1e-021pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 78 1e-015","SMU.654","","Residues 31 to 205 (E-value = 1.1e-51) place SMu0596 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Dec 12 17:55:04 2001","24379127","","","Cvitkovitch DG, Gutierrez JA, Behari J, Youngman PJ, Wetz JE, Crowley PJ, Hillman JD, Brady LJ, Bleiweis ASTn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes.FEMS Microbiol Lett 2000 Jan 1;182(1):149-54 PubMed: 10612747PMID: 10612747","Thu May 5 12:02:50 2005","Thu May 5 12:02:50 2005","1","","","SMU.654","" "MI0009","14","715","702","atggattatatgctagagacgaaaaatttaactaaacagtttggtaagcaaacagcggttaaccaattgaatttgaaagttgaacgtcattcaatttatggtttgctggggcctaatggttccggcaaatcaacaacacttaaaatgattactggaatgctaagaaagacatctggtcacattcttatagacggacacgattggagccgcaaggatttagaaaatatcggggctctgattgaatcaccgccgctttatgaaaacctgactgcgcgtgaaaatttaaaggtaagaaccttgatgctgggtttacctgatagtcgcattgatgaggttttaaaaatagtggatctaaccaacacgggtaaaaaaagagcagggcaattttctatgggcatgaagcagcgtctgggtattgctatcgcacttttgaactcacctcaacttttgattctggatgaaccgactaatggacttgatcctattggtattcaggagttgcgtaatcttattcgttccttccctacacaaggaattacagttattatttccagtcatatcttatctgagattcagatgacagcggatcatattggtatcattgctaatggcgtactgggttatcaggatagaattcaccaagatgaagacttggaaaaactttttactgatgtggttatgagataccgaggaggtgagtga","","","25958","MDYMLETKNLTKQFGKQTAVNQLNLKVERHSIYGLLGPNGSGKSTTLKMITGMLRKTSGHILIDGHDWSRKDLENIGALIESPPLYENLTARENLKVRTLMLGLPDSRIDEVLKIVDLTNTGKKRAGQFSMGMKQRLGIAIALLNSPQLLILDEPTNGLDPIGIQELRNLIRSFPTQGITVIISSHILSEIQMTADHIGIIANGVLGYQDRIHQDEDLEKLFTDVVMRYRGGE$","715 mutF ABC transporter; may be involved with immunity","","MutF protein from strain CH43; ABC transporter ATP binding","Cytoplasm, Membrane","This sequence corresponds to GI:9802351 and gi9802352 in GenBank. Similarities are to gi9802003, gi4322367, gi55847608, gi4098078 and other bacteriocin-related ABC transporter sequences.Nearest non-mutans neighbor in the NR db is gi2127220 from B.subtilis.","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[128-171]T$	ABC_transporter
PF00005	$\"[30-204]T$	ABC_tran
PS50893	$\"[5-228]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[29-205]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-229]T$	G3DSA:3.40.50.300
PTHR19222	$\"[5-233]T$	PTHR19222
PTHR19222:SF16	$\"[5-233]T$	PTHR19222:SF16
SSF52540	$\"[4-214]T$	SSF52540

","","","","","","","","","","","","","","","Thu May 5 20:25:34 2005","Thu May 12 14:10:13 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","Similarities are several to UA159 chromosomal sequences for ABC transporters such as Smu0596, Smu1649, Smu0944 and others.","Thu May 5 20:21:24 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","","Thu May 5 20:21:24 2005","","5","","","","" "SMu0597","615641","615889","249","ATGCTGGGCATGTTTCAGACAGAAAGATTAAAACTGAAGCGTACGATGGCAAAGAAATTATTATTTCTTGGTCCACTATTGGTAGTAATACATGGTTTTATGGCACCTCAGTATTTGATTACGGATGCCTATAATTGGTGGTATATCATGATTTTTCCAGGACTACTGACCTTATTTGCTGCTTTAATAAATACTTACGAAGAAAAAAGCTGCATTATCGAGCAATCTTTCCTTTGCCCATTTCTTTAA","8.70","2.13","9593","MLGMFQTERLKLKRTMAKKLLFLGPLLVVIHGFMAPQYLITDAYNWWYIMIFPGLLTLFAALINTYEEKSCIIEQSFLCPFL","615886","","mutE like protein, possibly bacteriocin associated","Membrane, Cytoplasm","Matches in gapped BLAST to MutE and to SpaE : residues 1-80 are 66% similar to the protein in S.mutans CH43 (gi9802353).Residues 1-80 are 28% similar to the protein in B.subtilis (gi16223976).SMu0597 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[20-40]?$ $\"[44-64]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-80 are 66% similar to a (SPAE NISE MEMBRANE SRTE) protein domain (PD038660) which is seen in Q9FDH3_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:12:32 2005","Tue May 3 12:19:06 2005","Tue May 3 12:19:06 2005","Wed Dec 12 17:58:28 2001","","Wed Dec 12 17:58:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0597 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 17:59:45 2001","","No significant hits to the NCBI PDB database.","SMU.655","","No significant hits to the Pfam 11.0 database","Wed Dec 12 17:58:28 2001","24379128","","","","Tue May 3 12:19:06 2005","","1","","","SMU.655","" "SMu0598","615874","616389","516","TTGCCCATTTCTTTAAGAAAATTTTGGATAAATAAAGTGCTGACTTTGGCTTATTATTTGACTCTGAGCAGCTTCTTGCATTGTTTTATTTTAGTCTTGTTGAAATATTTTATTTTTCCACATTATGGAGAAACTTACCTTATTAGTCAAATGCTTCTTGCTTCTATGGTCTTATTGCTCAGTGTACTTTGGCAGCTTCCATTTTGTTTATGGCTAGCAAAGAAATTGGGCCTAGTTATCACCGTGTTAGTCAATTTCACAGCTAATGTTATTTTGGGAATTGCTTTTTCAACGACTGCTTATTGGTTGCTGTGTCCTTATGCTTGGAGCATACGATTGATGATACCTCTTATGAAAATATATCCCAATGGTCTGAAAGCTGGATCAGAAGCCGCAGCACCGCTATTAGCAACCAGCAATTGGTCCATTATGCTCAGTTTAACTTTGGCGCTTATCCTTTTTGCAGGACTGACCTGGCTGACGGCTCTTTGGTTTGAAAAACAGGAGGTCAAGTAA","10.20","7.32","19468","MPISLRKFWINKVLTLAYYLTLSSFLHCFILVLLKYFIFPHYGETYLISQMLLASMVLLLSVLWQLPFCLWLAKKLGLVITVLVNFTANVILGIAFSTTAYWLLCPYAWSIRLMIPLMKIYPNGLKAGSEAAAPLLATSNWSIMLSLTLALILFAGLTWLTALWFEKQEVK","616386","For other components see SMu0596 (NBD1) and SMu0599 (MSD2).","ABC transporter, permease, possibly bacteriocin associated","Membrane, Cytoplasm","Matches in gapped BLAST to MutE proteins:residues 1-171 are 53%similar to the previously published protein in S.mutans (gi9802353).Residues 1-165 are 31% similar to SpaE in Bacillus subtilis (gi2702245). SMu0598 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-28]?$	signal-peptide
tmhmm	$\"[15-33]?$ $\"[52-72]?$ $\"[82-104]?$ $\"[143-163]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-160 are 51% similar to a (SPAE NISE MEMBRANE SRTE) protein domain (PD038660) which is seen in Q9FDH3_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:20:06 2005","Tue May 3 12:20:06 2005","Tue May 3 12:20:06 2005","Wed Dec 12 18:02:08 2001","","Wed Dec 12 18:02:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0598 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 18:03:09 2001","","No significant hits to the NCBI PDB database.","SMU.656","","No significant hits to the Pfam 11.0 database","Wed Dec 12 18:02:08 2001","24379129","","Qi F, Chen P, Caufield PW Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes. Appl Environ Microbiol 1999 Sep;65(9):3880-7 PubMed: 10473390 PMID: 10473390 Qi F, Chen P, Caufield PW Functional analyses of the promoters in the lantibiotic mutacin IIbiosynthetic locus in Streptococcus mutans. Appl Environ Microbiol 1999 Feb;65(2):652-8 PubMed: 9925596 PMID: 9925596 Cvitkovitch DG, Gutierrez JA, Behari J, Youngman PJ, Wetz JE, Crowley PJ, Hillman JD, Brady LJ, Bleiweis AS Tn917-lac mutagenesis of Streptococcus mutans to identifyenvironmentally regulated genes. FEMS Microbiol Lett 2000 Jan 1;182(1):149-54 PubMed: ","","Tue May 3 12:20:06 2005","","1","","","SMU.656","" "SMu0599","616389","617135","747","ATGGTTAAATTGATTTGGGCAGAGTTTTTAAAATATAACCGTACCTTTTTGCCTTGGATACATGTTATTTTACCAGTTGGCATCGCTGTTTTAACGGCTGTCTTTGGTCTGGTGACACCTGCTTATTCTTGGGGGAGTATTACAAGTGGTTATTTACAAGTGCTGGGGATTGCTTTTCCGTTAGTCATTGCTATTACTTGCAGCAAAGCTGTTGAATTAGAGGCGGAAGCTGGTCATTTTCAAACTGTCCTAGCAAATAGTCAACGAAAAGTTCTTTATTTTATAAAGCTTGTCAATCTTATGCTGATGGAAATTATCGCTGTTTGTCTAGCTCTGTCTGTCTTTGGTCTATTGTATCGTTCAAAAATAGATGTCCCCTATCTTGCCTTTTACGGTTATGCGGGATTACTTTTGATAGCATCAACAGTTATTTTATATTTACTACATCTGGTTATTGCTTTTTTATTTGATAGCGGGGCAACGATTGGTCTAGGTATTTTTGAAGTTCTGGTTTCGGCCTTGCTTTTAACAGGCTTAGGTGATAATATCTGGCAATTTGTGCCTGCTGCTTGGCCAGCACGGTTGATGGGAACCTTGTTTGAAATGTTGCAGTATCCTGATCAAAAACCTATTTTTGCCCAGCAGATTCTCCTCTGGCTGGAAGTCGCAGTCCCACTAACTTTAATGGCTTTAATCCTTAGTATAATCTGGTTCGACAGATGGCAAGGACGTAGCAATGAGGAATAG","6.30","-1.38","27672","MVKLIWAEFLKYNRTFLPWIHVILPVGIAVLTAVFGLVTPAYSWGSITSGYLQVLGIAFPLVIAITCSKAVELEAEAGHFQTVLANSQRKVLYFIKLVNLMLMEIIAVCLALSVFGLLYRSKIDVPYLAFYGYAGLLLIASTVILYLLHLVIAFLFDSGATIGLGIFEVLVSALLLTGLGDNIWQFVPAAWPARLMGTLFEMLQYPDQKPIFAQQILLWLEVAVPLTLMALILSIIWFDRWQGRSNEE","617132","For other components see SMu0596 (NBD1) and SMu0598 (MSD1).","ABC transporter, permease, possibly bacteriocin associated","Membrane, Cytoplasm","Matches in gapped BLAST to MutG:residues 1-248 are 55% similar to the previously published protein in S.mutans (gi9802354).Residues 52-248 are 29% similar to the protein SpaG from Bacillus subtilis (gi16223979). SMu0599 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-36]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[41-63]?$ $\"[97-119]?$ $\"[129-149]?$ $\"[154-176]?$ $\"[216-238]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 52-248 are 55% similar to a (SPAG SRTG MUTG) protein domain (PD108611) which is seen in Q9FDH2_STRMU.Residues 1-51 are 54% similar to a (MUTG) protein domain (PD248684) which is seen in Q9FDH2_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:21:09 2005","Tue May 3 12:21:09 2005","Tue May 3 12:21:09 2005","Wed Dec 12 18:06:26 2001","","Wed Dec 12 18:06:26 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0599 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 12 18:07:06 2001","","No significant hits to the NCBI PDB database.","SMU.657","","No significant hits to the Pfam 11.0 database","Wed Dec 12 18:06:26 2001","24379130","","Qi F, Chen P, Caufield PW Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes. Appl Environ Microbiol 1999 Sep;65(9):3880-7 PubMed: 10473390 PMID: 10473390 Qi F, Chen P, Caufield PW Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in Streptococcus mutans. Appl Environ Microbiol 1999 Feb;65(2):652-8 PubMed: 9925596 PMID: 9925596 Cvitkovitch DG, Gutierrez JA, Behari J, Youngman PJ, Wetz JE, CrowleyPJ, Hillman JD, Brady LJ, Bleiweis AS Tn917-lac mutagenesis of Streptococcus mutans to identify environmentally regulated genes. FEMS Microbiol Lett 2000 Jan 1;182(1):149-54 PubMed: ","","Tue Oct 29 10:02:58 2002","","1","","","SMU.657","" "SMu0600","617511","618350","840","ATGACAAATAGAAAAACACTAACGGGATTTCAGCTCAAATACATTGCTCTAGGAGCTATGTTATTGGACCATATTCATTATTTTTTTGAGTACACAGGTAAGGTTCCCCTATGGTTTACTCAAGTGGGGAGAATAGCCGCTCCATTATTTTTATTTGCTATTATTGAGGGTTTTATTCATACTCATGACCGAAAAAAATATTTCCTGAAGATTTACGGCTTAGCTGTTATAATGGGACTTATTCAGTTTGGCTTTTATAATGTGCTTCACCCTTTGGTGCGGGGAGATGGTTTTTTTCCAAAGAATATGATGCTGTCTTCATTTGCTATCTTACTGGTTGCTTTACAAGGTATTGCTTGGATCGAGGAGAAAAAGTATCTTAGAGGGATACCGACACTCCTTTTTCCGATTATTCTTCCCTTTCTCTTTATGCCTTTTTATCGTCTTTTCATGGCTTCAGACAATGATTTAGGTATGTTTGTGGTTAATCTGCTGAATTTCACTGTTCTGCCATTACATTTTTCCATTATGGATGGTGGAACAGCGACTTTGATTGTAGGAATAGCAATGTATCTTTGTCGAAAAACTATAAAAAGGGAAGTTATAGCTTTTGTGATCATTTCTTTGATCATTGATTTAGGCCGTGTATGGTTATCAGGTATTCCGTTAACATTTCATGGTCTCTTCTTTTCTTATTTTGAGTGGTTAGAAATTTTTGCAGCTCCTCTGATGCTAATGTACAATGGCAAACGAGGTAAAGGCAATAAATATCTCTTTTATGCTTTCTATCCTCTGCATATTTACTTGCTTTATACCTTGTCAGTATTACTTTATAGATGA","10.50","12.86","32318","MTNRKTLTGFQLKYIALGAMLLDHIHYFFEYTGKVPLWFTQVGRIAAPLFLFAIIEGFIHTHDRKKYFLKIYGLAVIMGLIQFGFYNVLHPLVRGDGFFPKNMMLSSFAILLVALQGIAWIEEKKYLRGIPTLLFPIILPFLFMPFYRLFMASDNDLGMFVVNLLNFTVLPLHFSIMDGGTATLIVGIAMYLCRKTIKREVIAFVIISLIIDLGRVWLSGIPLTFHGLFFSYFEWLEIFAAPLMLMYNGKRGKGNKYLFYAFYPLHIYLLYTLSVLLYR","618347","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical proteins: residues 1-277are 27% similar to the protein in Lactococcus lactis subsp. lactis (gi|15673353|).SMu0600 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[4-178]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[10-28]?$ $\"[42-62]?$ $\"[71-89]?$ $\"[103-121]?$ $\"[130-150]?$ $\"[169-191]?$ $\"[201-221]?$ $\"[227-247]?$ $\"[257-277]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-270 are 27% similar to a (ASSEMBLY FIMC SEROGROUP FIMBRIAL) protein domain (PD038706) which is seen in Q9CFU4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 18 09:19:17 2002","Wed Dec 12 18:10:22 2001","Fri Jan 18 09:19:17 2002","Wed Dec 12 18:08:29 2001","","Wed Dec 12 18:08:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0600 is paralogously related (blast p-value < 1e-3) to SMu1691, a predicted conserved hypothetical protein.","Fri Jan 18 09:19:17 2002","","No significant hits to the NCBI PDB database.","SMU.658","","No significant hits to the Pfam 11.0 database","Wed Dec 12 18:08:29 2001","24379131","","","","","","1","","","SMU.658","" "SMu0601","618390","619049","660","ATGACCCGTATTTTGGTAATTGATGATGAAGAAGATATTTTGGCTCTGATAAAAAATACCTTGCAACTGCAAAACTATCTGGTAAAGACTTTTGTCAGTGCCAATCAGGTTGACCGCTCAAAATTAGCAGACTATGATTTGATTTTACTGGACATTATGATGCCTGATGTGGACGGGCTCAGTTTTTGTCGGGACATTCGGAATTTGGTGGACTGTCCCATTCTTTTTCTGACAGCTAAGTCACAGGAAGCAGATGTTGTCACGGGGCTTAGTTATGGAGCAGATGATTATATTTGCAAGCCTTTTGGTGTGCAGGAATTGCTGGCGCGTGTTGATGCCCATCTGCGTCGAGAAAGGCGTGAGCACCATGCTAGTCTGGTTCTTGAGCCTATCCGCTTTGATCTTTCTGCTAAGCGGGTTACTGCTAAGGGAAAGAAACTTGATTTGACCAAGTCTGAGTATGAAATCTGTGAACTGTTAGCCAAGCGTCGCGGTCAAGTTTTTTCTAAAGATCAGCTTTATGATTATTTGTATACTTATGAAGAACGGGGAACACCTGCGGCTATAGCAGAGCATATCAAAAATATTCGGGCTAAGTTTAGAACTATTGGGCTTGAGCCCATTGAAACGGTCTGGGGGATAGGCTATAAATGGAAATGA","6.50","-1.22","25199","MTRILVIDDEEDILALIKNTLQLQNYLVKTFVSANQVDRSKLADYDLILLDIMMPDVDGLSFCRDIRNLVDCPILFLTAKSQEADVVTGLSYGADDYICKPFGVQELLARVDAHLRRERREHHASLVLEPIRFDLSAKRVTAKGKKLDLTKSEYEICELLAKRRGQVFSKDQLYDYLYTYEERGTPAAIAEHIKNIRAKFRTIGLEPIETVWGIGYKWK","619046","For other 'spa' genes see SMu0556 (spaP) and SMu0602 (spaK).From Genbank:[gi:417799]This protein is a member of the two-component regulatory system SPAK/SPAR involved in the regulation of the biosynthesis of lantibiotic subtilin.SPAR may function as a regulatory protein .","response regulator","Cytoplasm","Matches in gapped BLAST to responder protein:residues 1-219 are 31% similar to the previously published enzyme in S.mutans (gi|14600271|). Several matches to subtilin biosynthesis regulator SpaR: residues 1-219 are 46% similar to the enzyme in B.subtilis (gi|16223977|). Residues 1-218 are 38% similar to the protein from Lactococcus lactis (gi|628953|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2122 (3e-31).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[3-115]T$	Response_reg
PF00072	$\"[2-112]T$	Response_reg
SM00448	$\"[2-111]T$	REC
PS50110	$\"[3-115]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[147-218]T$	Trans_reg_C
PF00486	$\"[144-218]T$	Trans_reg_C

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-186]T$	CheY_like

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[126-218]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[3-125]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[3-120]T$	PTHR23283
PTHR23283:SF21	$\"[3-120]T$	PTHR23283:SF21

","BeTs to 8 clades of COG0745COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG0745 is -----QVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 10","***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 1.5e-53. IPB001867A 46-59 IPB001867B 73-117 IPB001867C 147-178 IPB001867D 204-218***** IPB001789 (Response regulator receiver domain) with a combined E-value of 2.3e-17. IPB001789A 4-10 IPB001789B 46-59 IPB001789C 93-102","Residues 3-115 are 55% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in SPAR_BACSU.Residues 126-219 are 47% similar to a (DNA-BINDING TRANSDUCTION SENSORY TRANSCRIPTION) protein domain (PD000329) which is seen in Q9ZEG3_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 10:52:04 2002","Tue Jan 8 12:12:16 2002","Thu Oct 24 10:52:04 2002","Thu Dec 13 08:33:15 2001","Thu Dec 13 08:33:15 2001","Thu Dec 13 08:33:15 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0601 is paralogously related (blast p-value < 1e-3) to SMu1379, SMu1748, SMu1048, SMu1653, SMu0947, SMu1032, SMu0918, SMu0841, SMu0441, SMu1782, SMu1406, and SMu0525, all predicted response regulators.","Wed Jan 23 08:38:23 2002","Thu Dec 13 08:33:15 2001","pdb|1B00|A Chain A, Phob Receiver Domain From Escherichia Coli ... 71 9e-014pdb|1QKK|A Chain A, Crystal Structure Of The Receiver Domain An... 62 5e-011","SMU.659","","Residues 2 to 119 (E-value = 3.2e-32) place SMu0601 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 144 to 218 (E-value = 7.7e-19) place SMu0601 in the Trans_reg_C family which is described as Transcriptional regulatory protein, C terminal (PF00486)","Thu Dec 13 08:33:15 2001","24379132","","","Klein,C., Kaletta,C. and Entian,K.D.Biosynthesis of the lantibiotic subtilin is regulated by ahistidine kinase/response regulator systemAppl. Environ. Microbiol. 59 (1), 296-303 (1993)PubMed: 8439156Klein,C. and Entian,K.D.Genes involved in self-protection against the lantibiotic subtilinproduced by Bacillus subtilis ATCC 6633Appl. Environ. Microbiol. 60 (8), 2793-2801 (1994)PubMed: 8085823","Wed Jan 23 08:38:23 2002","Thu Dec 13 08:38:17 2001","1","","","SMU.659","" "SMu0602","619040","620422","1383","ATGGAAATGAAAAAATCAGGTCGCTCTTTAAAAATGATTTTTACCCAGTATTTTGCGACAGTTAGTTTGGCTTTCATTGCTTTACTATGCCTAATTTGGGCTATTTTTGTCATAAGTCTCAATACCAAGCTTATCATTCCTGCCAATCAGACAGAACAAGAACTCCATCGCTTAGAAGATAAAATTGAAAAAGCTGATACTTTTCAAGCCAAACGTTTGCCCAAAGACACGGCTTATCTTTTAATGACCAAAGATGGCAAGATCAAAGAAAGCAATATGTCCAAAAACCTGCAGCAACAAGCTTTAGCTAGCTATTCTGGGAACGCGGTCAGCCCTAATGATTATGGCTATTTTATGGTTTTTAAACGTCAGAAGGAAGTCTGCATTGTCAATTACCGACTGGAAGCTCATTATTCAGTTGCCTGGATGAATAAGTATCTTCCTAATGTGAGTCTATTAGGACTTATTTTGACAGGGCTTGGAGTATTGCTTGTGTTTACTTTAGTGACGATACTCTTTGCCCGCAGGCTTCAGCGACAATTGTCTCCGATTATTGCTGCTACGCAGAAAATAGCCAAGCAGAATTTGGATTTCACAGTACAATCATCTGATATTAAGGAATTTAATCAAGTTTTAAATAGCTTGGATACCATGCGAGCAGCCTTGAGGGATTCCTTGATGCACAGCTGGCAAGTGGAGCAGGAGAAGCAAAATCAAATAGCTGCCTTAACACATGATATTAAAACGCCGCTGACAGTCATTAAAGGGAATACGGAACTGCTCAAGCAAACGGAGCTATCAGAGACTCAGGAGGCATTTGTTGGCTACAGTTTAAAAAATATTGGACAGGTAGAGACCTATCTTCAGCAATTGTCCTATCTAGCTAAAAACAGCCAATTACAAGATTTTCACCCTGAAAAGATAAAGGTCGCAGCCTTTTTGGAAGAATTATCCCAAAACAGCCAAGCCCTTGCTGCAACGAAAGATATAAAGATTCAATTTGTCAATAATTTGTCTGATGCTCAGCTCACTACTTATTGGGATAAAGGATTGTTGGCGCGTGCACTGATGAACATTATTTCCAATGCAGTAGAGCATAGTCCCCAAGGCAGTCAGCTGCAGTTAGTCTGTCATCTGGAAAATGAGCTTTTTCAATTGACTTGTCTGGATAGCGGTCAGGGCTTTTCAAGAGAGGCTTTAGATAAAGCAAAGATGCAATTTTTCCAAGATGATACCAGCCGTCATGACCGCAAGCATAGCGGTCTTGGTCTAACTATTGCAGACAATATTATTCGTTTGCATGGAGGAAGCTTGAGCTTATCTAATGATGCTAAAACAGCCAGCGGCAGAGTTGATGTCGTCTTACCACTGGCTAAAATGTAA","9.10","7.24","51801","MEMKKSGRSLKMIFTQYFATVSLAFIALLCLIWAIFVISLNTKLIIPANQTEQELHRLEDKIEKADTFQAKRLPKDTAYLLMTKDGKIKESNMSKNLQQQALASYSGNAVSPNDYGYFMVFKRQKEVCIVNYRLEAHYSVAWMNKYLPNVSLLGLILTGLGVLLVFTLVTILFARRLQRQLSPIIAATQKIAKQNLDFTVQSSDIKEFNQVLNSLDTMRAALRDSLMHSWQVEQEKQNQIAALTHDIKTPLTVIKGNTELLKQTELSETQEAFVGYSLKNIGQVETYLQQLSYLAKNSQLQDFHPEKIKVAAFLEELSQNSQALAATKDIKIQFVNNLSDAQLTTYWDKGLLARALMNIISNAVEHSPQGSQLQLVCHLENELFQLTCLDSGQGFSREALDKAKMQFFQDDTSRHDRKHSGLGLTIADNIIRLHGGSLSLSNDAKTASGRVDVVLPLAKM","620419","For other 'spa' genes see SMu0556 (spaP) and SMu0601 (spaR).","histidine kinase","Membrane, Cytoplasm","Matches weakly in gapped BLAST to sensor protein : residues 233-456 are 22% similar to the previously published enzyme in S.mutans (gi|14600272|). Matches to subtilin biosynthesis sensor protein:residues 5-457 are 33% similar to the protein in B.subtilis (gi|6226707|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0394 (3e-17).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[301-459]T$	ATP_bd_ATPase
PF02518	$\"[347-458]T$	HATPase_c
SM00387	$\"[347-459]T$	HATPase_c
SSF55874	$\"[305-456]T$	ATP_bd_ATPase

InterPro
IPR003660
Domain

Histidine kinase, HAMP region
PF00672	$\"[155-224]T$	HAMP
SM00304	$\"[175-227]T$	HAMP
PS50885	$\"[175-227]T$	HAMP

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[235-300]T$	HisKA
SM00388	$\"[235-300]T$	HisKA

InterPro
IPR004358
Domain

Histidine kinase related protein, C-terminal
PR00344	$\"[384-398]T$ $\"[418-436]T$	BCTRLSENSOR

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[242-459]T$	HIS_KIN

InterPro
IPR008358
Family

Lantibiotic regulatory protein
PR01780	$\"[207-221]T$ $\"[244-260]T$ $\"[343-358]T$ $\"[408-423]T$	LANTIREGPROT

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[225-296]T$	His_kin_homodim

noIPR
unintegrated

unintegrated
PTHR23283	$\"[5-457]T$	PTHR23283
PTHR23283:SF20	$\"[5-457]T$	PTHR23283:SF20

","BeTs to 13 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 352-453 are 42% similar to a (TRANSDUCTION TRANSFERASE PHOSPHORYLATION) protein domain (PD404615) which is seen in SPAK_BACSU.Residues 5-230 are 28% similar to a (SPAK TRANSFERASE PHOSPHORYLATION 2.7.3.-) protein domain (PD088769) which is seen in SPAK_BACSU.Residues 231-332 are 38% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD000142) which is seen in SPAK_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 10:52:35 2002","Tue Jan 8 12:12:50 2002","Thu Oct 24 10:52:35 2002","Thu Dec 13 08:42:52 2001","","Thu Dec 13 08:42:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0602 is paralogously related (blast p-value < 1e-3) to SMu1652, SMu1047, SMu1378, SMu0919, SMu1031, SMu0946, and SMu0842, all predicted histidine kinases.","Wed Jan 23 08:42:59 2002","","No significant hits to the NCBI PDB database.","SMU.660","","Residues 155 to 224 (E-value = 9.6e-09) place SMu0602 in the HAMP family which is described as HAMP domain (PF00672)Residues 235 to 300 (E-value = 3.4e-13) place SMu0602 in the HisKA family which is described as His Kinase A (phosphoacceptor) domain (PF00512)Residues 347 to 458 (E-value = 7.7e-20) place SMu0602 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Thu Dec 13 08:42:52 2001","24379133","","","Klein,C., Kaletta,C. and Entian,K.D.Biosynthesis of the lantibiotic subtilin is regulated by ahistidine kinase/response regulator systemAppl. Environ. Microbiol. 59 (1), 296-303 (1993)PubMed: 8439156Klein,C. and Entian,K.D.Genes involved in self-protection against the lantibiotic subtilinproduced by Bacillus subtilis ATCC 6633Appl. Environ. Microbiol. 60 (8), 2793-2801 (1994)PubMed: 8085823","","Thu Dec 13 08:42:52 2001","1","","","SMU.660","" "SMu0603","620728","620973","246","ATGCCAATACTTAAAAATCGACTTAAAGAACTACGTGCTAGAGATGGTATTAATCAGACCCAACTTGCTAAATTAGCAGGCATTTCCCGACAGACAGTCAGTTTAATAGAGCGTAATGAATACACACCTTCTGTTGTCATCGCCTTTAAGATTGCTAAATCTTTTGGTGAACCTGTGGAGAATGTTTTTAGTTTAATGGAGGAAGAAAACGAAAAAGTTAAACGGAGCTGTAGTAAGAAGAGTTAA","10.40","4.94","9178","MPILKNRLKELRARDGINQTQLAKLAGISRQTVSLIERNEYTPSVVIAFKIAKSFGEPVENVFSLMEEENEKVKRSCSKKS","620970","","transcriptional regulator","Cytoplasm, Periplasm","Several matches in gapped BLAST to transcriptional regulator proteins: residues 3-69 are 82% similar to the protein in S.pyogenes (gi|15675312|).Residues 4-69 are 72% similar to the protein from S.pneumoniae (gi|15901934|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0815 (2e-24).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[8-62]T$	HTH_3
SM00530	$\"[7-62]T$	HTH_XRE
PS50943	$\"[8-62]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[3-68]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[3-68]T$	G3DSA:1.10.260.40

InterPro
IPR003675
Family

Abortive infection protein
PF02517	$\"[132-223]T$	Abi

","BeTs to 7 clades of COG1266COG name: Predicted membrane proteinFunctional Class: SThe phylogenetic pattern of COG1266 is --T--qvC-BR-----o-in-Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 133-228 are 31% similar to a (COMPLETE PROTEOME TRANSMEMBRANE ABIGII) protein domain (PD038917) which is seen in Q9ETE8_STRPN.Residues 131-221 are 34% similar to a (PROTEOME COMPLETE PLASMID BINDING) protein domain (PD396338) which is seen in Q47774_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 09:55:01 2002","Fri Oct 11 13:28:43 2002","Fri Oct 11 13:28:43 2002","Thu Dec 13 08:58:00 2001","","Thu Dec 13 08:58:00 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0604 is paralogously related (blast p-value < 1e-3) to SMu1793, a predicted conserved hypothetical protein.","Wed Jan 23 12:15:51 2002","","No significant hits to the NCBI PDB database.","SMU.662","","Residues 132 to 223 (E-value = 7.7e-10) place SMu0604 in the Abi family which is described as CAAX amino terminal protease family (PF02517)","Thu Dec 13 08:58:00 2001","24379135","","","","","","1","","","SMU.662","" "SMu0605","621942","622964","1023","ATGAAAGTTTCGATTGTCGGTATTACAGGATATAGTGGATTAGAATTAGTCCGAATCTTAAATGGCCATCAGAAAGTTGAGCTCGTATCTGTCCATGCTACTAAGGAGATTGGAACAAAATTATCTGATATTTATTCATATTTAAAAGGAATTTGTGATTTAGAAATTCAATCTTTTGATAGTCAAAAAATAATGGCGACAGCTGATTTGGTCTTTTTTGCTACCCCCAGCGGTGTCGCTAAAGAATTAGCTAAAGACTTCATTGCAGCTGATTTTCCAGTCATTGATATCTCTGGAGATCATCGTCTGCCTGCTGCTATTTATGAAAAATGGTATAAGAAAGCAGCAGCTGAACAAGCATCTTTGGATAAATTCACATACGCTCTGGCCGAATTGACAGATGTTAAGGGAAAGAAATTCATTGCTAATCCAGGCTGTTATGCGACAGCAACTGAATTGGCTTTGCTTCCTTTGGTTAAGGAGAAACTTATTGATGTGAACAGTATCATCGTGGACGCTAAGTCTGGACTAACAGGAGCAGGCAAGGTCTTGTCAGAGTCCAGTCATTTTGTCAATGTCCATGATAATTACGTTACTTACAAGTTAAACCGCCATCAACATATTCCTGAAATTGTCCAAGAGTTGAAACGATTTGATAACAACTTGGAACATATCCAATTTTCAACCTCGCTTTTGCCTGTTAATCGTGGCATTATGGCAACCTGTTATGTCACTTTAAAAAAGCCTTTAAGCAATGAAGCCGTTAGCAAAATTTATCAGGATCTTTATGCAGATAAGCCTTTTGTCCGCTTACAGCAAGACTTGCCAGAATTGCATAATGTCATTGGTTCAAATTTTTGTGATATTGGCTTTGCCTATAATCCAGTAACCAATGTCCTAACAGTCATTTCGGTTATTGATAATCTGGTTAAAGGAGCAGCTGGTCAGGCTGTTCAAAATCTCAATTTGATGATGGGCTGGGATGAGACAGAAGGCTTCCCGATGACACCTAGTTATTTATAA","6.20","-4.01","37507","MKVSIVGITGYSGLELVRILNGHQKVELVSVHATKEIGTKLSDIYSYLKGICDLEIQSFDSQKIMATADLVFFATPSGVAKELAKDFIAADFPVIDISGDHRLPAAIYEKWYKKAAAEQASLDKFTYALAELTDVKGKKFIANPGCYATATELALLPLVKEKLIDVNSIIVDAKSGLTGAGKVLSESSHFVNVHDNYVTYKLNRHQHIPEIVQELKRFDNNLEHIQFSTSLLPVNRGIMATCYVTLKKPLSNEAVSKIYQDLYADKPFVRLQQDLPELHNVIGSNFCDIGFAYNPVTNVLTVISVIDNLVKGAAGQAVQNLNLMMGWDETEGFPMTPSYL","622961","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0606 (argJ);SMu0607 (argB); SMu0608 (argD);SMu1904 (argS); SMu1903 (argR);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH). ","N-acetyl-gamma-glutamyl-phosphate reductase (N-acetyl-glutamate-gamma-semialdehyde dehydrogenase)","Cytoplasm","Several matches in gapped BLAST to N-acetyl-gamma-glutamyl-phosphate reductase: residues 2-338 are 55% similar to the enzyme in Lactococcus lactis subsp. lactis (gi15672779).Residues 1-339 are 47% similar to the enzyme in Bacillus stearothermophilus (gi7431542).SMu0605 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000534
Domain

Semialdehyde dehydrogenase, NAD - binding
PF01118	$\"[2-132]T$	Semialdhyde_dh

InterPro
IPR000706
Domain

N-acetyl-gamma-glutamyl-phosphate reductase
PD003765	$\"[171-329]T$	AGPR_act_site
TIGR01850	$\"[1-340]T$	argC
PS01224	$\"[141-157]T$	ARGC

InterPro
IPR011137
Family

N-acetyl-gamma-glutamyl-phosphate reductase, monofunctional
PIRSF000150	$\"[1-340]T$	NAGSA_deh

InterPro
IPR012280
Domain

Semialdehyde dehydrogenase, dimerisation region
PF02774	$\"[155-311]T$	Semialdhyde_dhC

noIPR
unintegrated

unintegrated
SSF51735	$\"[1-187]T$	SSF51735
SSF55347	$\"[146-308]T$	SSF55347

","BeTs to 11 clades of COG0002COG name: Acetylglutamate semialdehyde dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0002 is amtkyqvcebr----------Number of proteins in this genome belonging to this COG is 1","***** IPB000706 (N-acetyl-gamma-glutamyl-phosphate reductase, active site) with a combined E-value of 1.5e-66. IPB000706A 3-24 IPB000706B 71-80 IPB000706C 94-113 IPB000706E 141-158 IPB000706F 173-185 IPB000706G 200-211 IPB000706H 227-241 IPB000706I 300-333***** IPB000534 (Semialdehyde dehydrogenase) with a combined E-value of 4.4e-17. IPB000534A 141-158 IPB000534B 307-319***** IPB000319 (Aspartate-semialdehyde dehydrogenase) with a combined E-value of 3.2e-06. IPB000319A 3-14 IPB000319I 307-321","Residues 3-103 are 53% similar to a (DEHYDROGENASE REDUCTASE) protein domain (PD119122) which is seen in ARGC_LACLA.Residues 108-332 are 58% similar to a (DEHYDROGENASE REDUCTASE) protein domain (PD003765) which is seen in ARGC_LACLA.Residues 1-102 are 42% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD001262) which is seen in Q9JVU6_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:46:50 2007","Tue Oct 8 09:55:37 2002","Fri Mar 16 11:46:50 2007","Thu Dec 13 09:25:55 2001","Thu Dec 13 09:25:55 2001","Thu Dec 13 09:25:55 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0605 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 13 09:32:14 2001","","No significant hits to the NCBI PDB database.","SMU.663","","Residues 1 to 142 (E-value = 9.9e-30) place SMu0605 in the Semialdhyde_dh family which is described as Semialdehyde dehydrogenase, NAD binding domain (PF01118)Residues 155 to 311 (E-value = 1.2e-35) place SMu0605 in the Semialdhyde_dhC family which is described as Semialdehyde dehydrogenase, dimerisation domain (PF02774)","Fri Mar 16 11:46:50 2007","24379136","","","Sakanyan,V., Charlier,D., Legrain,C., Kochikyan,A., Mett,I.,Pierard,A. and Glansdorff,N.Primary structure, partial purification and regulation of keyenzymes of the acetyl cycle of arginine biosynthesis in Bacillusstearothermophilus: dual function of ornithine acetyltransferaseJ. Gen. Microbiol. 139 (Pt 3), 393-402 (1993)PubMed: 8473852Savchenko,A., Charlier,D., Dion,M., Weigel,P., Hallet,J.N.,Holtham,C., Baumberg,S., Glansdorff,N. and Sakanyan,V.The arginine operon of Bacillus stearothermophilus:characterization of the control region and its interaction with the heterologous B. subtilis arginine repressorMol. Gen. Genet. 252 (1-2), 69-78 (1996)PubMed: 8804405","","Thu Dec 13 10:18:17 2001","1","","","SMU.663","" "SMu0606","623123","624316","1194","ATGAAAATAATTGATGGAAATATTGCCAGTCCGCTAGGTTTCTCAGCGGATGGCTTACATGCTGGTTTTAAAAAGAGAAAAAAAGATTTTGGCTGGATTGTGTCAGAAGTTCCAGCAAGTGTGGCAGGTGTTTATACAACCAATAAAGTCATTGCCGCACCGCTGATTGTTACCAGAGAGTCTGTGAAAAAGGCTCAAAAAATGCAAGCTCTTGTTGTTAACTCAGGCGTTGCTAATTCATGTACCGGCCTTCAAGGAATGGAAGATGCTTATACCATGCAAAAATGGACAGCAACGAAGCTAAAGATTGCTCCTGAGTTGGTTGGTGTTGCTTCAACAGGCGTCATTGGTGACTTGATGCCCATGGATACTTTGCAAAAAGGTCTTTCTAAATTAGTGGTCAATGGGAATTCAGATGATTTTGCGCAAGCTATCTTGACGACAGACACAAAAGTTAAGACAGTGGCTGTAACAGAGCAATTTGGTCGTGATGAGGTTACTATGGCAGGTGTCGCCAAGGGTTCTGGTATGATTCACCCTAATATGGCAACCATGTTAGCCTTTATTACTTGTGATGCTGTCATTTCAAGCGAAACGCTGCAGCTGGCTCTTAGTCAAAATGTTGAAACGACGTTTAATCAAATTACAGTAGATGGTGACACTTCAACTAATGACATGGTCCTTGTCCTCTCTAATGGCTGTACCTTAAATAAGGAAATACTGCCAGATACACCGGAGTTTGATAAGTTTTCAGCTATGCTTCATTTTGTCATGCAAGAGTTGGCTAAGAAAATTGCCAAGGATGGTGAAGGGGCGACTAAGCTCATTGAGGTTGAAGTGATCAATGCTCCTAATAGTTTAGATGCATGTATGATGGCTAAAAGTGTTGTTGGTTCTAGCCTTGTTAAAACGGCAATTTTTGGTGAAGATCCCAATTGGGGACGTATTTTGGCAGCAGTTGGCTATGCTGGTGTTGATGTTCCCGTGGATAATATTGATATTTATCTGGCAGACATTCCAGTCATGCTAGCTTCTAGTCCTGTTGATTTTGATGAGGAAGACATGCAGGATGTCATGCGAGCAGATACTATTAAGATTATTGTGGATTTGCATGCAGGGGACAGTGTTGGTAAGGCTTGGGGTTGTGATTTGTCCTATGATTATGTTAAAATCAATGCCCTCTATCGGACCTAG","4.60","-14.25","42408","MKIIDGNIASPLGFSADGLHAGFKKRKKDFGWIVSEVPASVAGVYTTNKVIAAPLIVTRESVKKAQKMQALVVNSGVANSCTGLQGMEDAYTMQKWTATKLKIAPELVGVASTGVIGDLMPMDTLQKGLSKLVVNGNSDDFAQAILTTDTKVKTVAVTEQFGRDEVTMAGVAKGSGMIHPNMATMLAFITCDAVISSETLQLALSQNVETTFNQITVDGDTSTNDMVLVLSNGCTLNKEILPDTPEFDKFSAMLHFVMQELAKKIAKDGEGATKLIEVEVINAPNSLDACMMAKSVVGSSLVKTAIFGEDPNWGRILAAVGYAGVDVPVDNIDIYLADIPVMLASSPVDFDEEDMQDVMRADTIKIIVDLHAGDSVGKAWGCDLSYDYVKINALYRT","624313","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0607 (argB); SMu0608 (argD);SMu1904 (argS); SMu1903 (argR);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH).From Genbank:[gi:584771]This protein catalyses two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetlyglutamate from glutamate and acetyl-CoA and of ornithine by transacetylation between acetylornithine and glutamate .","ornithine acetyltransferase / N-acetylglutamate synthase","Cytoplasm","Several matches in gapped BLAST to ornithine acetyltransferase/N-acetylglutamate synthase: residues 1-397 are 55% similar to the enzyme in Listeria innocua (gi16800700). Residues 1-395 are 54% similar to the protein from Lactococcus lactis subsp. lactis (gi15672780).SMu0606 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002813
Family

Arginine biosynthesis protein ArgJ
PD004193	$\"[7-191]T$ $\"[209-395]T$	ArgJ
PTHR23100	$\"[20-397]T$	ArgJ
PF01960	$\"[14-397]T$	ArgJ
TIGR00120	$\"[4-397]T$	ArgJ

noIPR
unintegrated

unintegrated
SSF56266	$\"[10-394]T$	SSF56266

","BeTs to 8 clades of COG1364COG name: Ornithine acetyltransferase/N-acetylglutamate synthaseFunctional Class: EThe phylogenetic pattern of COG1364 is amt--qvc-br----------Number of proteins in this genome belonging to this COG is 1","***** IPB002813 (ArgJ family) with a combined E-value of 8e-139. IPB002813A 42-54 IPB002813B 68-83 IPB002813C 112-132 IPB002813D 142-153 IPB002813E 170-208 IPB002813F 214-233 IPB002813G 258-302 IPB002813H 303-323 IPB002813I 370-397","Residues 22-397 are 50% similar to a (ORNITHINE TRANSFERASE ACETYLTRANSFERASE) protein domain (PD004193) which is seen in O08319_LACPL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 11:47:29 2007","Tue Oct 8 09:55:57 2002","Fri Mar 16 11:47:29 2007","Thu Dec 13 10:19:59 2001","Thu Dec 13 10:19:59 2001","Thu Dec 13 10:19:59 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0606 is paralogously related (blast p-value < 1e-3) to SMu0208, a predicted conserved hypothetical protein; possible kinase.","Wed Jan 23 12:22:07 2002","","No significant hits to the NCBI PDB database.","SMU.664","","Residues 14 to 397 (E-value = 7.2e-211) place SMu0606 in the ArgJ family which is described as ArgJ family (PF01960)","Thu Dec 13 10:19:59 2001","24379137","","","Sakanyan,V., Charlier,D., Legrain,C., Kochikyan,A., Mett,I.,Pierard,A. and Glansdorff,N.Primary structure, partial purification and regulation of keyenzymes of the acetyl cycle of arginine biosynthesis in Bacillusstearothermophilus: dual function of ornithine acetyltransferaseJournal of general microbiology. 139 (Pt 3), 393-402 (1993)PubMed: 8473852","","Thu Dec 13 10:27:48 2001","1","","","SMU.664","" "SMu0607","624345","625082","738","ATGAAAGATATTATTGTTATTAAAATTGGCGGAGTAGCAAGTCAACAGCTGAGTGGAGATTTTCTCAGTCAAATCAAGAACTGGCAGGATGCTGGCAAACAGCTTGTTATCGTCCATGGCGGTGGCTTTGCGATTAATAAGTTAATGGAAGAAAATCAGGTTCCAGTCAAAAAAATCAATGGCTTGCGTGTCACTAGCAAAGATGACATGGTTTTGGTAAGTCACGCTCTTCTTGATTTGGTTGGAAAGAATTTACAGGAAAAATTAAGGCAGGCAGGTGTCAGCTGTCAGCAGTTAAAATCGGACATTAAGCATGTAGTGGCTGCTGATTATCTAGATAAAGACACCTATGGCTATGTCGGCGATGTGACGCATATTAATAAAAGGGTCATTGAAGAATTCCTTGAGAACAGGCAGATTCCTATTCTTGCTTCTTTAGGCTATTCCAAAGAAGGGGACATGCTCAATATCAATGCGGATTATCTAGCGACAGCAGTAGCGGTAGCACTTGCGGCTGATAAACTGATTTTGATGACCAACGTTAAAGGTGTTTTAGAAAATGGAGCTGTGCTGGAAAAGATAACAAGTCATCAAGTCCAAGAAAAGATTGATACAGCTGTTATTACTGCTGGTATGATTCCCAAAATTGAGAGCGCTGCTAAAACAGTAGCCGCAGGCGTCGGGCAGGTTTTAATTGGAGATAATTTATTGACAGGAACGCTTATCACGGCAGATTAA","6.40","-1.84","26297","MKDIIVIKIGGVASQQLSGDFLSQIKNWQDAGKQLVIVHGGGFAINKLMEENQVPVKKINGLRVTSKDDMVLVSHALLDLVGKNLQEKLRQAGVSCQQLKSDIKHVVAADYLDKDTYGYVGDVTHINKRVIEEFLENRQIPILASLGYSKEGDMLNINADYLATAVAVALAADKLILMTNVKGVLENGAVLEKITSHQVQEKIDTAVITAGMIPKIESAAKTVAAGVGQVLIGDNLLTGTLITAD","625079","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0608 (argD);SMu1904 (argS); SMu1903 (argR);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH).","acetylglutamate kinase","Cytoplasm, Membrane","Matches in gapped BLAST to acetylglutamate kinase: residues 1-232 are 31% similar to the enzyme in B.stearothermophilus (gi|584767|)and 30% similar to the protein from B.subtilis (gi|16078186|).SMu0607 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001048
Domain

Aspartate/glutamate/uridylate kinase
G3DSA:3.40.1160.10	$\"[1-244]T$	Aa_kinase
PF00696	$\"[3-234]T$	AA_kinase
SSF53633	$\"[2-243]T$	Aa_kinase

InterPro
IPR001057
Domain

Glutamate 5-kinase
PR00474	$\"[32-46]T$ $\"[158-185]T$	GLU5KINASE

InterPro
IPR004662
Domain

Acetylglutamate kinase
TIGR00761	$\"[4-232]T$	argB

InterPro
IPR011148
Family

N-acetylglutamate kinase
PIRSF000728	$\"[1-244]T$	NAGK

","BeTs to 11 clades of COG0548COG name: Acetylglutamate kinaseFunctional Class: EThe phylogenetic pattern of COG0548 is amtkyqvcEbr----------Number of proteins in this genome belonging to this COG is 1","***** IPB001057 (Glutamate 5-kinase) with a combined E-value of 8.2e-17. IPB001057A 18-43 IPB001057C 156-189 IPB001057D 202-234","Residues 1-232 are 31% similar to a (KINASE ACETYLGLUTAMATE TRANSFERASE NAG) protein domain (PD003894) which is seen in ARGB_BACST.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 13:44:22 2002","Wed Jan 23 12:23:03 2002","Fri Oct 11 13:40:00 2002","Thu Dec 13 10:43:02 2001","Thu Dec 13 10:43:02 2001","Thu Dec 13 10:43:02 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0607 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 13 10:45:28 2001","","No significant hits to the NCBI PDB database.","SMU.665","","Residues 3 to 234 (E-value = 3.7e-35) place SMu0607 in the AA_kinase family which is described as Amino acid kinase family (PF00696)","Thu Dec 13 10:43:02 2001","24379138","","","Sakanyan,V., Charlier,D., Legrain,C., Kochikyan,A., Mett,I.,Pierard,A. and Glansdorff,N.Primary structure, partial purification and regulation of keyenzymes of the acetyl cycle of arginine biosynthesis in Bacillusstearothermophilus: dual function of ornithine acetyltransferaseJ. Gen. Microbiol. 139 (Pt 3), 393-402 (1993)PubMed: 8473852O'Reilly,M. and Devine,K.M.Sequence and analysis of the citrulline biosynthetic operon argC-Ffrom Bacillus subtilisMicrobiology 140 (Pt 5), 1023-1025 (1994)PubMed: 8025667","","Fri Oct 11 13:44:22 2002","1","","","SMU.665","" "SMu0608","625218","626357","1140","ATGAGTAACTTATTTCAAAACTATACAAGAGCAGATCTTGAGTTTATCAAAGCAGAAGGTAATTATCTCTTTGATACACAAGGGAAAAAATACCTTGATTTTTCAACAGGCATTGGCGTGACTAATCTGGGTTTTCATCCGCAAGTTCAAGTTGCCTTGCAAAAACAGGCTGAGCAAATTTGGCACACACCCAATCTTTATCAAAATAGTTTGCAAGAAGAAGTCGCTGCTAAGTTGATGGCTGGTAAGGATTATTTAGCTTTCTTTTGTAATAGCGGTGCAGAGGCCAATGAAGCGGCTATTAAAATTGCCCGTAAAGCAACGGGCAAGCAAGAGATTATTACTTTTCAGAATTCCTTCCATGGCAGGACCTTTGGCTCCATGTCAGCGACAGGACAGGATAAAATCAAAGTCGGTTTTGGTGACGCTGTCCCGCATTTTCACTATGCTGTTTTCAATGACTTGAACAGTGTTAAAGCTTTGGTGACAGAAAACACAGCTGCTGTTATGCTGGAACTCGTTCAAGGAGAGTCTGGTGTGCTGCCTGCTGAGCAGGACTTCGTGACAGCCCTAGCTGATTACTGTCAGAAGAATGGTCTGTTGCTTATCATAGATGAGGTACAGACAGGTATGGGACGGACTGGCAAGCTCTATGCCTTCCAGCACTATGGCATTGAACCGGATATTTTTACATTGGCAAAAGGTCTAGCCAACGGAGTCCCTGTTGGTGCCATGTTGGCAAAAAAGCAGTTTGGCAGTGCCTTTGGTCCCGGTTCGCACGGTTCAACCTTTGGCGGCAATAAATTAGCCATGGCAGCCAGTTCGGCCGTTCTTGATATTATGACTAAGGCAGGTTTTTTAGAGCAGGCTTGGGAGAATGCTCATTATTTACAAGAGCAGCTCACGTCTGCCTTGCAGGTTGCTGATACGGTCACTCAAGTGCGCGGACTGGGTTATATGATAGGTATTGAAACGACAGCTGACCTTGGTCAGCTGGTCAAGGCTACTCGCGACCGAGGTTTGATCGTCCTGACAGCAGGAACCAATGTTATCAGGCTCTTACCGCCGTTGACTCTGACCAAGGATGAGATCGATCAAGGCATAATGATTTTACAGGAAGTGTTTGAACAGCATAATTGA","5.60","-6.91","41130","MSNLFQNYTRADLEFIKAEGNYLFDTQGKKYLDFSTGIGVTNLGFHPQVQVALQKQAEQIWHTPNLYQNSLQEEVAAKLMAGKDYLAFFCNSGAEANEAAIKIARKATGKQEIITFQNSFHGRTFGSMSATGQDKIKVGFGDAVPHFHYAVFNDLNSVKALVTENTAAVMLELVQGESGVLPAEQDFVTALADYCQKNGLLLIIDEVQTGMGRTGKLYAFQHYGIEPDIFTLAKGLANGVPVGAMLAKKQFGSAFGPGSHGSTFGGNKLAMAASSAVLDIMTKAGFLEQAWENAHYLQEQLTSALQVADTVTQVRGLGYMIGIETTADLGQLVKATRDRGLIVLTAGTNVIRLLPPLTLTKDEIDQGIMILQEVFEQHN","626354","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0607 (argB);SMu1904 (argS); SMu1903 (argR);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH).","N-acetylornithine aminotransferase","Cytoplasm","This sequence was previously published in GenBank (gi|1213508|) and defined as N-acetylornithine aminotransferase from S.mutans.Residues 1-379 are 51% similar to the enzyme in B.subtilis (gi|16078187|). Residues 1-379 are 50% similar to the protein from Lactococcus lactis subsp. lactis (gi|15672781|).SMu0608 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004636
Family

Acetylornithine and succinylornithine aminotransferase
PTHR11986:SF19	$\"[2-378]T$	ArgD_aminotrans
TIGR00707	$\"[3-376]T$	argD

InterPro
IPR005814
Family

Aminotransferase class-III
PTHR11986	$\"[2-378]T$	Aminotrans_3
PF00202	$\"[14-327]T$	Aminotran_3
PS00600	$\"[202-239]T$	AA_TRANSFER_CLASS_3

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[46-285]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[1-377]T$	PyrdxlP-dep_Trfase_major

","BeTs to 11 clades of COG0160COG name: PLP-dependent aminotransferasesFunctional Class: EThe phylogenetic pattern of COG0160 is AmtKYqvcEBRh---------Number of proteins in this genome belonging to this COG is 2","***** IPB000954 (Aminotransferase class-III pyridoxal-phosphate) with a combined E-value of 4.4e-41. IPB000954A 25-54 IPB000954B 176-215 IPB000954C 224-239 IPB000954D 260-278","Residues 135-267 are 36% similar to a (FISSION YEAST) protein domain (PD200245) which is seen in P78766_SCHPO.Residues 320-376 are 45% similar to a (AMINOTRANSFERASE PYRIDOXAL PHOSPHATE COMPLETE PROTEOME) protein domain (PD001337) which is seen in Q9P3I3_NEUCR.Residues 171-231 are 45% similar to a (AMINOTRANSFERASE PYRIDOXAL PHOSPHATE) protein domain (PD000465) which is seen in Q9US34_SCHPO.Residues 86-273 are 62% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in ARGD_BACSU.Residues 16-365 are 25% similar to a (TRANSFERASE 6-AMINOTRANSFERASE L-LYSINE) protein domain (PD308202) which is seen in Q9EVJ7_BBBBB.Residues 7-45 are 58% similar to a (AMINOTRANSFERASE PYRIDOXAL PHOSPHATE PROTEOME COMPLETE) protein domain (PD000493) which is seen in Q9CHD3_LACLA.Residues 167-270 are 28% similar to a (PHOSPHOPANTETHEINE) protein domain (PD336190) which is seen in Q9WWD9_AGRTU.Residues 212-267 are 57% similar to a (AMINOTRANSFERASE COMPLETE PROTEOME) protein domain (PD249119) which is seen in Q9CNT1_PASMU.Residues 88-131 are 52% similar to a (AMINOTRANSFERASE PYRIDOXAL PHOSPHATE COMPLETE PROTEOME) protein domain (PD186083) which is seen in P78766_SCHPO.Residues 262-318 are 43% similar to a (AMINOTRANSFERASE PYRIDOXAL TRANSAMINASE) protein domain (PD098527) which is seen in ARGD_THEMA.Residues 223-324 are 35% similar to a (RHBA) protein domain (PD262795) which is seen in Q9RFF8_RHOSH.Residues 239-372 are 28% similar to a (AMINOTRANSFERASE PROTEOME LONG COMPLETE) protein domain (PD397896) which is seen in Q9YBY6_AERPE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 16:19:17 2002","Tue Jan 15 11:08:50 2002","Tue Oct 22 16:19:17 2002","Thu Dec 13 10:46:52 2001","Thu Dec 13 10:46:52 2001","Thu Dec 13 10:46:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0608 is paralogously related (blast p-value < 1e-3) to SMu0341 a predicted N-acetylornithine aminotransferase.","Tue Jan 15 11:17:00 2002","Thu Dec 13 10:46:52 2001","pdb|1GBN|A Chain A, Human Ornithine Aminotransferase Complexed ... 190 2e-049pdb|2OAT|A Chain A, Ornithine Aminotransferase Complexed With 5... 190 2e-049pdb|1D7U|A Chain A, Crystal Structure Of The Complex Of 2,2-Dia... 159 4e-040","SMU.666","","Residues 2 to 379 (E-value = 8.1e-143) place SMu0608 in the Aminotran_3 family which is described as Aminotransferase class-III (PF00202)","Thu Dec 13 10:46:52 2001","24379139","","Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P. and Bleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 8763945","O'Reilly,M. and Devine,K.M.Sequence and analysis of the citrulline biosynthetic operon argC-Ffrom Bacillus subtilisMicrobiology 140 (Pt 5), 1023-1025 (1994)PubMed: 8025667Bringel,F., Frey,L., Boivin,S. and Hubert,J.C.Arginine biosynthesis and regulation in Lactobacillus plantarum:the carA gene and the argCJBDF cluster are divergently transcribedJ. Bacteriol. 179 (8), 2697-2706 (1997)PubMed: 9098069","Tue Jan 15 11:10:18 2002","Tue Oct 22 16:19:17 2002","1","","","SMU.666","" "SMu0609","627440","626481","960","ATGACAACTTACTATGAAGCAATAAATTGGAACGAAATTGAAGATGTCATTGACAAGTCTACTTGGGAAAAATTAACCGAGCAATTTTGGTTGGATACCCGTATTCCTCTGTCAAATGACTTGGATGACTGGCGTAAGTTATCTGCCGCAGAAAAAGACCTCGTTGGTAAAGTTTTTGGCGGTCTAACATTATTAGACACCATGCAATCCCAATCAGGTGTAGAAGCTATCCGCGGCGATGTTCGCACACCACACGAAGAAGCTGTGTTGAACAATATCCAATTTATGGAATCTGTCCACGCCAAATCTTACTCATCAATCTTTTCAACGCTTAACACTAAGTCTGAGATTGAAGGGATTTTTGAATGGACCAATAATAATGAATACTTGCAAAAAAAGGCTAAGATTATTAATGAGATCTATGAAAATGGAAATGCTCTCCAAAAGAAAGTTGCTTCTACTTTTCTTGAAACTTTTCTTTTCTACTCAGGTTTCTTTACGCCACTCTACTACCTCGGTAACAATAAACTAGCCAATGTGGCTGAAATCATTAAGCTCATTATTCGTGATGAGTCTGTTCATGGTACCTACATTGGCTACAAATTCCAGCTTGGCTTTAATGAATTGTCTGAAGAAGAACAAAGCGAATTTCGTGATTGGATGTATGATTTACTCTACCAACTCTATGAGAATGAGGAACTTTATACCCAAACACTCTATGATCCAGTCGGCTGGACTGAGGAAGTCATGACCTTCCTGCGTTATAATGCCAATAAAGCACTCATGAATTTGGGACAGGATCCTCTTTTTCCAGATACCGCCAATGATGTCAATCCAATTGTCATGAATGGTATCTCAACGGGAACATCAAACCACGATTTCTTCTCACAAGTCGGTAATGGTTACCTGCTTGGTTCTGTTGAAGCCATGCATGATGACGATTATCTCATGGGAAAATAA","4.30","-24.76","36775","MTTYYEAINWNEIEDVIDKSTWEKLTEQFWLDTRIPLSNDLDDWRKLSAAEKDLVGKVFGGLTLLDTMQSQSGVEAIRGDVRTPHEEAVLNNIQFMESVHAKSYSSIFSTLNTKSEIEGIFEWTNNNEYLQKKAKIINEIYENGNALQKKVASTFLETFLFYSGFFTPLYYLGNNKLANVAEIIKLIIRDESVHGTYIGYKFQLGFNELSEEEQSEFRDWMYDLLYQLYENEELYTQTLYDPVGWTEEVMTFLRYNANKALMNLGQDPLFPDTANDVNPIVMNGISTGTSNHDFFSQVGNGYLLGSVEAMHDDDYLMGK","626484","For ribonucleotide reductase, large subunit see SMu0610.For other 'nrd' genes see SMu0611 (nrdH); SMu1882 (nrdD); SMu1879 (nrdG); SMu1135 (nrd); SMu1618 (nrdI), (nrd) and SMu0610 (nrdE).From Genbank:[gi:2507306]This enzyme catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides,precursors that are necessary for DNA synthesis.R2F contains the tyrosyl radical required for catalysis .","ribonucleotide reductase, small subunit","Cytoplasm","Several matches in gapped BLAST to ribonucleotide reductase, small subunit: residues 1-318 are 88% similar to the enzyme in S.pyogenes (gi15675308)and are 83% similar to the protein from S.pneumoniae (gi15901045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0818 (1e-167).","

InterPro
IPR000358
Family

Ribonucleotide reductase
PTHR23409	$\"[1-314]T$	Ribonucl_redctse
PF00268	$\"[1-280]T$	Ribonuc_red_sm

InterPro
IPR009078
Family

Ferritin/ribonucleotide reductase-like
SSF47240	$\"[4-285]T$	Ferritin/RR_like

InterPro
IPR012348
Family

Ribonucleotide reductase-related
G3DSA:1.10.620.20	$\"[6-290]T$	Ribncl_red_rel

noIPR
unintegrated

unintegrated
PTHR23409:SF5	$\"[1-314]T$	PTHR23409:SF5

","BeTs to 11 clades of COG0208COG name: Ribonucleotide reductase beta subunitFunctional Class: FThe phylogenetic pattern of COG0208 is ----YQ-cEBRhujgp-linxNumber of proteins in this genome belonging to this COG is 1","***** IPB000358 (Ribonucleotide reductase) with a combined E-value of 1.7e-34. IPB000358A 14-68 IPB000358B 89-114 IPB000358C 163-203 IPB000358D 227-237 IPB000358E 292-302","Residues 5-73 are 71% similar to a (REDUCTASE RIBONUCLEOTIDE) protein domain (PD006930) which is seen in Q9CGW8_LACLA.Residues 83-313 are 75% similar to a (REDUCTASE BETA CHAIN RIBONUCLEOTIDE) protein domain (PD219999) which is seen in Q9CGW8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 10:49:29 2006","Tue Oct 8 09:57:00 2002","Mon Sep 11 10:44:15 2006","Thu Dec 13 10:54:21 2001","Thu Dec 13 10:54:21 2001","Thu Dec 13 10:54:21 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0609 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 13 10:54:29 2001","Mon Sep 11 10:44:15 2006","pdb2R2FA Chain A, Ribonucleotide Reductase R2f Protein From S... 312 4e-086pdb1AV8A Chain A, Ribonucleotide Reductase R2 Subunit From E.... 63 5e-011pdb1XIKB Chain B, Ribonucleoside-Diphosphate Reductase 1 Beta... 63 5e-011","SMU.667c","","Residues 6 to 280 (E-value = 1.1e-58) place SMu0609 in the Ribonuc_red_sm family which is described as Ribonucleotide reductase, small chain (PF00268)","Thu Dec 13 10:54:21 2001","","","","Jordan,A., Gibert,I. and Barbe,J.Cloning and sequencing of the genes from Salmonella typhimuriumencoding a new bacterial ribonucleotide reductaseJ. Bacteriol. 176 (11), 3420-3427 (1994)PubMed: 8195103","","Thu Dec 13 11:09:51 2001","1","","","SMU.667c","327" "SMu0610","630162","628003","2160","ATGAGTTTAAAAAATCTTGGCGATATCTCTTACTTTCGCCTAAACAATGAAATTAATCGTCCTATTAATGGACAAATTCCACTTCATAAGGATAAGGAAGCTTTAGAAGCTTTCTTTAAAGAAAATGTCAAGCCAAATACCAAGACATTTGACAGCATTACTGATAAAATTCAGTTTTTAGTGGCTAATGACTATATCGAAGCTGAATTTATTGCTAAATATAAGTCAGAATTTATTGAACAGCTGTCTCAGGATCTTCATGCTTATGATTTTCAGTTTAAATCATTTATGGCGGCTTATAAATTTCATCAACAATATGCTCTAAAAACCAATGATGGAGAAGAATACTTAGAAAGCATTGAAGATCGCGTACTTTTCAATGCCCTTTATTTTGCTGATGGCAATGAGAATTTAGCTCATGACTTAGCCATGGAAATGATTGCCCAGCGTTATCAGCCTGCCACACCTTCTTTTCTTAATGCCGGGCGCAGCCGCCGAGGTGAATTAGTTTCTTGCTTCCTGATTCAAGTGACTGATGATATGAATTCAATCGGACGTTCGATCAACTCCGCTTTGCAATTGTCTCGTATTGGGGGAGGTGTTGGGATTTCCTTAAGCAACCTGCGTGAAGCTGGTGCTCCTATCAAAGGATTTGCTGGAGCTGCATCTGGTGTTGTTCCTGTTATGAAGCTGTTTGAAGATAGTTTTTCTTATTCTAACCAACTTGGACAGCGTCAAGGTGCTGGTGTTGTTTATTTAGATGTCTTCCATCCAGATATCATGGCCTTTCTTTCAACCAAGAAGGAAAATGCTGACGAAAAGGTTCGTGTTAAGACACTTTCTTTGGGTGTTACCATTCCTGATAAGTTTTATGAATTGGCTCGCAGGAACGAAGACATGTACCTCTTTAGTCCCTATTCTATTGAACGTGAATATGGTGTTCCTTATAACTATCTTGATATTACTGAAAAGTATGATGAATTGGTCGCCAACCCTAAGATTATCAAAACAAAGATTAAGGCTCGCGATTTGGAAACTGAAATTTCTAAATTACAGCAGGAATCTGGTTATCCTTACGTTGTCAATATTGATACAGCTAACCGTGCCAATCCAATTGATGGCAAAATTATTATGTCCAACTTGTGTTCTGAAATTCTTCAGGTTCAAAAGCCTAGCCTTATTAACGATGCGCAAGAATTTGTTAAAATGGGAACCGATATTTCATGTAATCTTGGTTCCACAAATGTTGTCAATATGATGACTTCACCTGATTTTGGTCGTTCTATCAAAGCCATGACACGTGCTCTGACTTTCGTTACAGATTCATCACATATTGATGCTGTCCCTTCTATCAAAAACGGCAATAAGCAGGCACATACTTTTGGACTTGGTGCTATGGGACTGCATTCTTATTTGGCACAAAATCATATTGAATATGGCAGTCCTGAATCCATTGAGTTTACTGATATTTACTTTATGCTCATGAATTACTGGACTCTGGTCGAATCCAATAATATCGCCCGCGAACGCCAAGAAACGTTTGTCGGTTTTGAAAAATCAAAATACGCTGATGGTTCTTATTTTGATAAATATGTAACTGGTCAGTTTATACCAAAATCTGACAAAATTAAAGAACTTTTCAAAAATCATTTCATTCCACAAGCTGAAGATTGGGAAGCCCTTCGTCAAGCAGTTATAAAAGATGGCCTTTATCATCAAAATCGTCTTGCCGTTGCCCCAAATGGTTCTATTTCTTACATTAATGATGTTTCTGCATCCATTCACCCTATTACCCGTCGAATTGAAGAGCGTCAAGAAAAGAAAATCGGGAAAATCTATTATCCAGCAGCTGGACTGTCAACAGATACCATTCCTTACTATACTTCTGCTTACGACATGGATATGCGTAAAGTGATTGACGTCTATGCCGCAGCTACGCAACACGTTGACCAAGGCATGTCACTGACACTCTTTATGCGCAGTGATATTCCACAAGGCATTTATGAATGGAAAACAGAGAGCAAACAAACCACACGTGACTTATCTATTCTGCGCAATTACGCCTTCAACAAGGGTATCAAATCCATCTACTATATCCGCACCTTCACTGATGATGGTGATGAAGTTGGTGCTAATGAATGTGAAAGCTGTGTGATTTAA","5.50","-13.03","81473","MSLKNLGDISYFRLNNEINRPINGQIPLHKDKEALEAFFKENVKPNTKTFDSITDKIQFLVANDYIEAEFIAKYKSEFIEQLSQDLHAYDFQFKSFMAAYKFHQQYALKTNDGEEYLESIEDRVLFNALYFADGNENLAHDLAMEMIAQRYQPATPSFLNAGRSRRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGISLSNLREAGAPIKGFAGAASGVVPVMKLFEDSFSYSNQLGQRQGAGVVYLDVFHPDIMAFLSTKKENADEKVRVKTLSLGVTIPDKFYELARRNEDMYLFSPYSIEREYGVPYNYLDITEKYDELVANPKIIKTKIKARDLETEISKLQQESGYPYVVNIDTANRANPIDGKIIMSNLCSEILQVQKPSLINDAQEFVKMGTDISCNLGSTNVVNMMTSPDFGRSIKAMTRALTFVTDSSHIDAVPSIKNGNKQAHTFGLGAMGLHSYLAQNHIEYGSPESIEFTDIYFMLMNYWTLVESNNIARERQETFVGFEKSKYADGSYFDKYVTGQFIPKSDKIKELFKNHFIPQAEDWEALRQAVIKDGLYHQNRLAVAPNGSISYINDVSASIHPITRRIEERQEKKIGKIYYPAAGLSTDTIPYYTSAYDMDMRKVIDVYAAATQHVDQGMSLTLFMRSDIPQGIYEWKTESKQTTRDLSILRNYAFNKGIKSIYYIRTFTDDGDEVGANECESCVI","628006","For ribonucleotide reductase, small subunit see SMu0609.For other 'nrd' genes see SMu0611 (nrdH); SMu1882 (nrdD); SMu1879 (nrdG); SMu1135 (nrd); SMu1618 (nrdI), (nrd) and SMu0609 (nrdF). ","ribonucleotide reductase, large subunit","Cytoplasm","Several matches in gapped BLAST to ribonucleotide reductase alpha-chain: residues 1-719 are 86% similar to the enzyme in S.pyogenes (gi15675307) and are 84% similar to the protein from S.pneumoniae (gi15901044).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0819 (0.0).","

InterPro
IPR000788
Domain

Ribonucleotide reductase large subunit, C-terminal
PR01183	$\"[245-264]T$ $\"[376-387]T$ $\"[459-481]T$ $\"[487-510]T$ $\"[569-596]T$	RIBORDTASEM1
PTHR11573	$\"[150-719]T$	Ribncl_red_lg_C
PF02867	$\"[169-703]T$	Ribonuc_red_lgC
PS00089	$\"[558-580]?$	RIBORED_LARGE

InterPro
IPR008926
Domain

Ribonucleotide reductase R1 subunit, N-terminal
SSF48168	$\"[8-168]T$	Ribonucleo_red_N

InterPro
IPR013346
Domain

Ribonucleoside-diphosphate reductase, alpha subunit
TIGR02506	$\"[96-702]T$	NrdE_NrdA

InterPro
IPR013509
Domain

Ribonucleotide reductase large subunit, N-terminal
PF00317	$\"[92-166]T$	Ribonuc_red_lgN

InterPro
IPR013554
Domain

Ribonucleotide reductase N-terminal
PF08343	$\"[11-91]T$	RNR_N

noIPR
unintegrated

unintegrated
G3DSA:3.90.244.10	$\"[386-704]T$	G3DSA:3.90.244.10
PTHR11573:SF4	$\"[150-719]T$	PTHR11573:SF4
SSF51998	$\"[169-704]T$	SSF51998

","BeTs to 15 clades of COG0209COG name: Ribonucleotide reductase alpha subunitFunctional Class: FThe phylogenetic pattern of COG0209 is a-tKYqvcEBRhujgp-linxNumber of proteins in this genome belonging to this COG is 2","***** IPB000788 (Ribonucleotide reductase large subunit) with a combined E-value of 1.5e-34. IPB000788C 144-174 IPB000788D 194-230 IPB000788E 245-267 IPB000788G 374-393 IPB000788I 558-596 IPB000788J 689-698","Residues 259-372 are 70% similar to a (REDUCTASE CHAIN) protein domain (PD001074) which is seen in Q9CGW7_LACLA.Residues 376-509 are 42% similar to a (REDUCTASE CHAIN) protein domain (PD000706) which is seen in Q9RZL7_DEIRA.Residues 517-639 are 70% similar to a (REDUCTASE RIBONUCLEOSIDE-DIPHOSPHATE DNA) protein domain (PD024116) which is seen in Q9CGW7_LACLA.Residues 407-510 are 60% similar to a (REDUCTASE RIBONUCLEOSIDE-DIPHOSPHATE REPLICATION) protein domain (PD001915) which is seen in Q9CGW7_LACLA.Residues 131-179 are 61% similar to a (REDUCTASE CHAIN DNA) protein domain (PD001726) which is seen in RIR1_BACSU.Residues 181-243 are 79% similar to a (REDUCTASE CHAIN) protein domain (PD001775) which is seen in Q9CGW7_LACLA.Residues 245-375 are 32% similar to a (PROTEOME REDUCTASE COMPLETE) protein domain (PD008445) which is seen in O53767_MYCTU.Residues 11-130 are 62% similar to a (REDUCTASE RIBONUCLEOSIDE-DIPHOSPHATE) protein domain (PD007357) which is seen in Q9CGW7_LACLA.Residues 643-700 are 50% similar to a (REDUCTASE CHAIN) protein domain (PD315834) which is seen in Q9CBQ0_MYCLE.Residues 132-179 are 72% similar to a (REDUCTASE RIBONUCLEOSIDE-DIPHOSPHATE) protein domain (PD378721) which is seen in Q9CGW7_LACLA.Residues 640-719 are 79% similar to a (PROTEOME CHAIN ALPHA COMPLETE) protein domain (PD390890) which is seen in Q9CGW7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 10:50:48 2006","Thu Dec 13 11:13:39 2001","Mon Sep 11 10:50:48 2006","Thu Dec 13 11:13:39 2001","Thu Dec 13 11:13:39 2001","Thu Dec 13 11:13:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0610 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 13 11:13:51 2001","Mon Sep 11 10:50:48 2006","pdb4R1RA Chain A, Ribonucleotide Reductase R1 Protein With Su... 161 4e-040pdb1RLR Structure Of Ribonucleotide Reductase Protein R1 161 4e-040pdb2R1RA Chain A, Ribonucleotide Reductase R1 Protein With Dt... 160 6e-040","SMU.668c","","Residues 92 to 166 (E-value = 1.1e-22) place SMu0610 in the Ribonuc_red_lgN family which is described as Ribonucleotide reductase, all-alpha domain (PF00317)Residues 169 to 703 (E-value = 1.4e-133) place SMu0610 in the Ribonuc_red_lgC family which is described as Ribonucleotide reductase, barrel domain (PF02867)","Mon Sep 11 10:50:48 2006","24379141","","","Oehlmann,W. and Auling,G.Ribonucleotide reductase (RNR) of Corynebacterium glutamicum ATCC13032--genetic characterization of a second class IV enzymeMicrobiology 145 (Pt 7), 1595-1604 (1999)PubMed: 10439398","","Tue Mar 19 12:57:51 2002","1","","","SMU.668c","88" "SMu0611","630586","630362","225","ATGGCTAAAATTACTGTTTTTTCAAAAAATAACTGCATGCAATGCAAAATGACTAAGAAGTTCCTAGAACAACATAACGCTGATTTCGAAGAAATCAATATTGATGAACAGCCGGAAAAAATCGAATATGTCAAAAGTCTAGGATTTACTGCCGCTCCTGTTATTGAAACAAGCGATCTTGTCTTCTCAGGGTTTCAGCCTGCTAAATTGAAAACCATTATTTAA","5.90","-0.87","8412","MAKITVFSKNNCMQCKMTKKFLEQHNADFEEINIDEQPEKIEYVKSLGFTAAPVIETSDLVFSGFQPAKLKTII","630365","For other 'nrd' genes see SMu0609 (nrdG),(nrdF); SMu1882 (nrdD); SMu1879 (nrdG); SMu1135 (nrd); SMu1618 (nrdI), (nrd) and SMu0610 (nrdE). This protein is involved in the electron transport system for ribonucleotide reductase system NRDEF [gi:2494805].","glutaredoxin","Cytoplasm","Several matches in gapped BLAST to glutaredoxin proteins: residues 4-74 are 80% similar to the enzyme in S.pyogenes (gi|15675306|). Residues 4-73 are 64% similar to the protein from S.pneumoniae (gi|15903108|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0820 (1e-32).","

InterPro
IPR002109
Domain

Glutaredoxin
PF00462	$\"[4-55]T$	Glutaredoxin

InterPro
IPR011909
Family

Glutaredoxin-like protein NrdH
TIGR02194	$\"[4-74]T$	GlrX_NrdH

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[2-73]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[2-74]T$	IPR012336

noIPR
unintegrated

unintegrated
PIRSF000078	$\"[1-72]T$	Glutaredoxin
PTHR10168	$\"[3-39]T$	PTHR10168
PTHR10168:SF16	$\"[3-39]T$	PTHR10168:SF16

","BeTs to 7 clades of COG0695COG name: Glutaredoxin and related proteinsFunctional Class: OThe phylogenetic pattern of COG0695 is a-tkY-vCEbrH-----l--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-67 are 43% similar to a (GLUTAREDOXIN ELECTRON PROTEOME TRANSPORT) protein domain (PD331281) which is seen in NRDH_ECOLI.Residues 17-70 are 57% similar to a (NRDH GLUTAREDOXIN-LIKE CENTER) protein domain (PD336670) which is seen in Q9CGW5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 20:25:35 2002","Thu Dec 13 14:10:28 2001","Thu Oct 24 12:16:26 2002","Thu Dec 13 14:10:28 2001","","Thu Dec 13 14:10:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0611 is paralogously related (blast p-value < 1e-3) to SMu1044, a predicted conserved hypothetical protein.","Wed Jan 23 12:28:16 2002","","No significant hits to the NCBI PDB database.","SMU.669c","","No significant hits to the Pfam 11.0 database","Thu Dec 13 14:10:28 2001","24379142","","","Jordan,A., Pontis,E., Aslund,F., Hellman,U., Gibert,I. andReichard,P.The ribonucleotide reductase system of Lactococcus lactis.Characterization of an NrdEF enzyme and a new electron transportproteinThe Journal of biological chemistry. 271 (15), 8779-8785 (1996)PubMed: 8621514Jordan,A., Aragall,E., Gibert,I. and Barbe,J.Promoter identification and expression analysis of Salmonellatyphimurium and Escherichia coli nrdEF operons encoding one of twoclass I ribonucleotide reductases present in both bacteriaMolecular microbiology. 19 (4), 777-790 (1996)PubMed: 8820648","","Thu Dec 13 14:27:12 2001","1","","","SMU.669c","919" "SMu0612","630841","633507","2667","ATGATTAATTATACATCAACTTTTACGTTGAATCGGCAAAAATATCACTATATTGATTTGGTAAAAGCTTCTAAAGACTATGATATAGAACTTGATAGTCTCCCTTATACAATTAAAATTTTGCTTGAAAGTTTATTGAGAAAGCACGACGATATTTGTGTCACAAAAAATAACATAGAAACTCTTTTTCATTATAATTCAAAAGCTCCTCAAGGAGAAGTACCTTTTAAACCTAGTCGAGTCATTTTGCAGGATTTTACGGGTGTTCCTGTTGTTGTTGACTTAGCTTCTATGCGGGATGCTGTCGTTGAAAATGGCGGCAGCCCAGATTTAATCAATCCTGAAATTCCAGTGGATTTAGTTATTGATCATAGTGTTCAAGTTGATTTTTTTGGAAATCAAGACGCATTTGACGCTAATATTGATTTAGAATTTGAACGAAATAATGAGCGTTATGAATTTCTTAAATGGGCTGAAAAAACTTTTGAAAATTATCGGGCCGTTCCTCCAGCAACAGGTATTATTCATCAGGTCAATCTTGAATTTTTGAGTGATGTGATTATTAATAAGGATGGTTTCTTATATCCAGATTCGATGTTTGGCACAGACAGTCATACAACCATGATCAATGGTATCGGTGTTTTAGGCTGGGGTGTCGGTGGCATTGAAGCCGAAGCAGCTATGTTAGGAGAAGCTTCTTATTTTCCCATCCCAGAAGTCATCGGTGTTCGTCTTTATGGAGAGCTTCCTAAAGTAGCGACAGCTACAGATTTAGCACTTAAGGTGACCCAAAAGCTGCGCTTAGAAAATGTTGTTGGCAAGTTTGTTGAGTTCTTCGGCCCCGGTTTAGCTGGACTTTCTTTGGCAGATCGCGCAACGGTTGCCAATATGGCACCTGAATATGGTGCAACCTGTGGTTATTTTCCGATTGATGATGAAACCTTAAATTATATGAAATTGACCAATCGCTCAGCAGAACACATTGCACTAACAAAAGAATATGCCAAGCGAAATCATCTTTACCATGATATGACAAATCTGCCTTCCTACACTAAAATAGTTGAAATTGATTTATCAGCCATTAAACCTTCTATCTCAGGCCCTAAACGGCCTCAAGATTTGATTGAATTGGGTCAAGCCAAAGAAGAATTTCAGGCGAGTTTGGTACGTCAGTTTGGTGTCCGCGGTTTTGGTCTAGGAGCTGATGAGTTGGCTAAAAAGGCGACTGTTCATTTTGATGATGGTCAGGAATTGGAAGTCAAAACAGGTCATGTTGCCATTGCAGCCATCACTTCTTGTACCAATACTTCTAATCCCTATGTTCTTTTATCAGCTGGACTTTTGGCTAAAAAAGCAGTTGAGCGTGGTTTATCGGTTGCCAAAACGGTGAAAACATCCTTAGCTCCAGGTTCTAAAGTGGTTACTGCTTATTTGCGAAAGAGTGGTCTACAACCCTATCTGGATAAGCTTGGATTCAATTTGGTTGGCTACGGTTGTACAACTTGTATCGGTAATTCAGGTGATTTGGTTCCAGAAGTTGCCAAGGCTGTTCAAGAGAAGGATTTATTAGTTAGTGCAGTTCTGTCAGGGAATCGGAATTTTGAAGGACGGGTCAATCCACTCGTCAAAGCTAATTTCCTAGCTAGCCCGCCTTTAGTTGTTGCTTACGCTTTGGCAGGTACTACCAATATTGACTTAACTTCTAAGCCTTTAGGCTATGATAAAAATGGCCAGGCTGTTTATCTTGAGGATATTATGCCTGCAAAAGAAGAAGTACTGTCTTATATTGAACAGTTTGTAACGGCTGAATTATTTGAAGAAGAATATGGTCATGTTTTTTCTGATAGTCAAAAATGGAATCAGATCGAAACAGAGAATTCCAAAAATTACCAATGGAATCAAGTCTCTACCTATATTCAAAATCCTCCTTATTTTGAGAATCTGACAAATACTGAGAACAAAATAGATTTAAGTGCATTAAAGGTTTTAGCCAAATTTGGAGATTCTGTAACCACAGATCATATTTCCCCAGCAGGTAATATTGCGAGAAATAGCCCTGCAGCTCGTTATTTAGAAGAAAATGGGGTGACTTATGCTGAGTTCAATTCTTACGGTAGCCGTCGTGGTAATCACGAGGTCATGATGCGAGGAACTTTTGCAAATATTCGTATCAAAAATGAATTAGCTGATGGCAAAATCGGTGGTTACACAAAATATGAAGGAGAAATCTTACCGATTTATGAGGCTGCCATGAATTATAAGAAAAACGGTGTTTCTACTATTGTTATTGCAGGAAAAGACTATGGTATGGGCTCTAGCCGTGATTGGGCTGCTAAGGGTGCCAATCTTTTAGGTGTCAAGGTCGTCTTAGCAGAAAGCTTTGAGCGGATTCATCGTTCTAATTTAGTCATGATGGGAATTTTACCTCTACAATTCCTTGATGGTCAAACGGCTGAAAGTCTCCAATTAACAGGATACGAAACTTACACTGTGGAACTTCCTGAACAGCCGCAAGTTCATGATATTGTTAAGGTAAAAGCTACTTCTAAGGAAGGGACTAAAGAATTTCAAGTGCTCTTACGTTTTGATGCGGATGCTGATATTCGCTATTATCAAAATGGCGGTATTCTTCCAATGGTTGTGCGTAAAAAATTGAATGGAGGTTAA","5.20","-19.28","98050","MINYTSTFTLNRQKYHYIDLVKASKDYDIELDSLPYTIKILLESLLRKHDDICVTKNNIETLFHYNSKAPQGEVPFKPSRVILQDFTGVPVVVDLASMRDAVVENGGSPDLINPEIPVDLVIDHSVQVDFFGNQDAFDANIDLEFERNNERYEFLKWAEKTFENYRAVPPATGIIHQVNLEFLSDVIINKDGFLYPDSMFGTDSHTTMINGIGVLGWGVGGIEAEAAMLGEASYFPIPEVIGVRLYGELPKVATATDLALKVTQKLRLENVVGKFVEFFGPGLAGLSLADRATVANMAPEYGATCGYFPIDDETLNYMKLTNRSAEHIALTKEYAKRNHLYHDMTNLPSYTKIVEIDLSAIKPSISGPKRPQDLIELGQAKEEFQASLVRQFGVRGFGLGADELAKKATVHFDDGQELEVKTGHVAIAAITSCTNTSNPYVLLSAGLLAKKAVERGLSVAKTVKTSLAPGSKVVTAYLRKSGLQPYLDKLGFNLVGYGCTTCIGNSGDLVPEVAKAVQEKDLLVSAVLSGNRNFEGRVNPLVKANFLASPPLVVAYALAGTTNIDLTSKPLGYDKNGQAVYLEDIMPAKEEVLSYIEQFVTAELFEEEYGHVFSDSQKWNQIETENSKNYQWNQVSTYIQNPPYFENLTNTENKIDLSALKVLAKFGDSVTTDHISPAGNIARNSPAARYLEENGVTYAEFNSYGSRRGNHEVMMRGTFANIRIKNELADGKIGGYTKYEGEILPIYEAAMNYKKNGVSTIVIAGKDYGMGSSRDWAAKGANLLGVKVVLAESFERIHRSNLVMMGILPLQFLDGQTAESLQLTGYETYTVELPEQPQVHDIVKVKATSKEGTKEFQVLLRFDADADIRYYQNGGILPMVVRKKLNGG","633504","For other 'cit' genes see SMu0613 (citZ);SMu0614 (citC); SMu0920 (citC); SMu0921 (citG);SMu0929 (citD); SMu0930 (citE); SMu0931 (citF) and SMu0932 (citX2). ","aconitate hydratase; aconitase A","Cytoplasm","Matches to a previously published Genbank sequence.Residues 626-888 are 100% similar to aconitase in S.mutans (gi|1421812|) and (gi|2492638|).Several matches in gapped BLAST to aconitate hydratase: residues 7-885 are 60% similar to the enzyme in B.subtilis (gi|16078863|). Residues 9-884 are 57% similar to the protein from Lactococcus lactis subsp. lactis (gi|15672653|).SMu0612 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000573
Domain

Aconitate hydratase, C-terminal
PF00694	$\"[687-815]T$	Aconitase_C

InterPro
IPR001030
Domain

Aconitate hydratase, N-terminal
PD000511	$\"[170-561]T$	Aconitase_N
PR00415	$\"[141-154]T$ $\"[165-173]T$ $\"[194-207]T$ $\"[208-223]T$ $\"[270-283]T$ $\"[284-297]T$ $\"[363-377]T$ $\"[429-440]T$ $\"[491-504]T$	ACONITASE
PF00330	$\"[53-560]T$	Aconitase
PS00450	$\"[425-441]T$	ACONITASE_1
PS01244	$\"[491-504]T$	ACONITASE_2
SSF53732	$\"[15-616]T$	Aconitase_N

InterPro
IPR006249
Family

Aconitate hydratase 1
TIGR01341	$\"[13-885]T$	aconitase_1

InterPro
IPR012084
Family

Aconitase/homoaconitase
PIRSF001417	$\"[4-887]T$	LysF

noIPR
unintegrated

unintegrated
G3DSA:3.20.19.10	$\"[650-886]T$	G3DSA:3.20.19.10
G3DSA:3.30.499.10	$\"[15-240]T$ $\"[359-574]T$	G3DSA:3.30.499.10
G3DSA:3.40.1060.10	$\"[241-358]T$	G3DSA:3.40.1060.10
PTHR11670	$\"[11-885]T$	PTHR11670
PTHR11670:SF1	$\"[11-885]T$	PTHR11670:SF1
SSF52016	$\"[630-886]T$	SSF52016

","BeTs to 6 clades of COG1048COG name: Aconitase AFunctional Class: CThe phylogenetic pattern of COG1048 is ----Yq--ebr---------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001030 (Aconitase (aconitate hydratase)) with a combined E-value of 1.5e-38. IPB001030A 210-258 IPB001030B 481-504 IPB001030C 526-540***** IPB000573 (Aconitase C-terminal domain) with a combined E-value of 2.6e-32. IPB000573 761-810","Residues 765-827 are 76% similar to a (HYDRATASE ACONITATE ACONITASE LYASE IRON-SULFUR CITRATE) protein domain (PD001077) which is seen in O50579_XANCA.Residues 561-762 are 54% similar to a (ACONITATE HYDRATASE ACONITASE LYASE CITRATE IRON-SULFUR) protein domain (PD004178) which is seen in Q9KAI8_BACHD.Residues 810-871 are 51% similar to a (HYDRATASE ACONITATE ACONITASE REGULATORY IRON LYASE) protein domain (PD094652) which is seen in Q9CHQ5_LACLA.Residues 173-306 are 28% similar to a (HACA) protein domain (PD299828) which is seen in Q9ZNE0_THETH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:01:03 2002","Fri Oct 11 14:01:03 2002","Fri Oct 11 14:01:03 2002","Thu Dec 13 15:21:19 2001","Thu Dec 13 15:21:19 2001","Thu Dec 13 15:21:19 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0612 is paralogously related (blast p-value < 1e-3) to SMu1260,a predicted 3-isopropylmalate dehydratase large subunit, and SMu1259 a predicted 3-isopropylmalate dehydratase small subunit.","Wed Jan 23 12:32:53 2002","Thu Dec 13 15:21:19 2001","pdb|5ACN| Aconitase (E.C.4.2.1.3) (Inactive (3fe-4s) Cluster... 202 1e-052pdb|1B0J|A Chain A, Crystal Structure Of Aconitase With Isocitr... 201 3e-052pdb|1C97|A Chain A, S642a:isocitrate Complex Of Aconitase >gi|6... 201 3e-052","SMU.670","","Residues 53 to 560 (E-value = 5.4e-210) place SMu0612 in the Aconitase family which is described as Aconitase family (aconitate hydratase) (PF00330)Residues 687 to 815 (E-value = 2.5e-55) place SMu0612 in the Aconitase_C family which is described as Aconitase C-terminal domain (PF00694)","Thu Dec 13 15:21:19 2001","24379143","","Cvitkovitch,D.G., Gutierrez,J.A. and Bleiweis,A.S.Role of the citrate pathway in glutamate biosynthesis byStreptococcus mutansJ. Bacteriol. 179 (3), 650-655 (1997)PubMed: 9006016","Dingman,D.W. and Sonenshein,A.L.Purification of aconitase from Bacillus subtilis and correlation of its N-terminal amino acid sequence with the sequence of the citB geneJ. Bacteriol. 169 (7), 3062-3067 (1987)PubMed: 3110133Viollier,P.H., Nguyen,K.T., Minas,W., Folcher,M., Dale,G.E. andThompson,C.J.Roles of Aconitase in Growth, Metabolism, and MorphologicalDifferentiation of Streptomyces coelicolorJ. Bacteriol. 183 (10), 3193-3203 (2001)PubMed: 11325949","Wed Jan 23 12:34:12 2002","Thu Dec 13 15:53:31 2001","1","","","SMU.670","" "SMu0613","633512","634630","1119","ATGGCAGAAACAAATGGCTTAAAGGACATGATTGCCTGTGATACAAGAATTAGTGCCATCAAGGATAATAAACTCTCGTATGCAGGTTATGATATTGCTGATTTAATGGACAATAAGGCTCGGTTTGAAGAGGTCATTTACCTCCTTTGGAATCTTCATTTACCAACAGCAATTGAACTGAAGCAATTTGAAGAGAAATTACGCAAAAATTATGCGATAAGTGATGCCATTGAACAATGTATTCTCATTCAATCGCGCCAGCACCTACACCCCATGAGTGTTTTGCGTTCAACGGTAAGTCTATTAGGCGTTTATAATTTAAAAGCTGAGGAAAGAAGTGTAGAAGCTACTTATGACCAAAGCATTCAGTTGATGGCCAAGATACCGACCATTATTGCAACCTTTGCAAGATTGCGTCAGGGGCTGTCTCCTATCGCTCCTAGAAAGGATCTTGGCTTCGCTGCTAATTTCCTATATATGTTAAATGGCCGCCTTCCAAGTGAATTAGAGATTTTAGCTATGAATCGTGCGCTTGTTCTACATGCTGAACATGAACTCAATGCCTCTACCTTTGCGGCTAGGGTTTGTGCCTCAACTCTATCAGATATTTACTCTTGTGTAACAACAGCTATTGGAACCTTAAAAGGTCCCTTGCACGGTGGTGCCAATGAGCGTGTATTTGATATGCTAAGAGAGATTCGTGAATACGGTGATGTTGACAGTTACTTGCAAGAAAAACTCAACTCTAAAGAAAAAATCATGGGCTTTGGGCATCGCGTTTATCAGACACAAGATCCACGTGAAAAATATTTGCGCGAAATGGCGAGAGAATTGACCAAGGGAACAGAGCATGACATTTGGTATCAATTATCCAAAAAAGTTGAAATTTGTATGAAGCAAAAGAAAAATCTAATTCCTAATGTTGATTTTTATTCGGCTACTGTTTACCATGTTTTAGGTATTGATAGTTCTATTTTTACCTTAATTTTTGCCATGAGCCGTGTTTCGGGTTGGATTGCCCATATTCAAGAGCAACAAAAAAATAACAAATTAATCCGTCCGCGCTCTCACTATACTGGTATGAGGAAGTTACGCTATATTCCTATTGAAAGGAGATAA","9.40","9.43","42699","MAETNGLKDMIACDTRISAIKDNKLSYAGYDIADLMDNKARFEEVIYLLWNLHLPTAIELKQFEEKLRKNYAISDAIEQCILIQSRQHLHPMSVLRSTVSLLGVYNLKAEERSVEATYDQSIQLMAKIPTIIATFARLRQGLSPIAPRKDLGFAANFLYMLNGRLPSELEILAMNRALVLHAEHELNASTFAARVCASTLSDIYSCVTTAIGTLKGPLHGGANERVFDMLREIREYGDVDSYLQEKLNSKEKIMGFGHRVYQTQDPREKYLREMARELTKGTEHDIWYQLSKKVEICMKQKKNLIPNVDFYSATVYHVLGIDSSIFTLIFAMSRVSGWIAHIQEQQKNNKLIRPRSHYTGMRKLRYIPIERR","634627","For other 'cit' genes see SMu0612 (citB);SMu0614 (citC); SMu0920 (citC); SMu0921 (citG);SMu0929 (citD); SMu0930 (citE); SMu0931 (citF) and SMu0932 (citX2). From genbank:[gi:3123196]This protein might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle.Loss in activity of this protein results in sporulation defect.","citrate synthase","Cytoplasm","Matches in gapped BLAST to citrate synthase: residues 1-372are 99% similar to the previously published enzyme in S.mutans (gi|2493722|).Residues 1-372 are 57% similar to the protein in Listeria innocua (gi|16800670|) and are 53% similar to the protein in B.subtilis (gi|16079966|).SMu0613 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002020
Family

Citrate synthase
PR00143	$\"[124-137]T$ $\"[173-188]T$ $\"[195-223]T$ $\"[248-268]T$ $\"[305-321]T$ $\"[325-339]T$	CITRTSNTHASE
PTHR11739	$\"[6-372]T$	Citrate_synth
PF00285	$\"[6-354]T$	Citrate_synt
PS00480	$\"[255-267]N$	CITRATE_SYNTHASE

InterPro
IPR011278
Family

2-methylcitrate synthase/citrate synthase II
TIGR01800	$\"[5-372]T$	cit_synth_II

noIPR
unintegrated

unintegrated
G3DSA:1.10.580.10	$\"[11-267]T$	G3DSA:1.10.580.10
PIRSF001369	$\"[3-372]T$	Citrate_synth
SSF48256	$\"[3-372]T$	SSF48256

","BeTs to 11 clades of COG0372COG name: Citrate synthaseFunctional Class: CThe phylogenetic pattern of COG0372 is a-T-YqvcEBR-uj------xNumber of proteins in this genome belonging to this COG is 1","***** IPB002020 (Citrate synthase) with a combined E-value of 4.2e-81. IPB002020A 6-26 IPB002020B 36-51 IPB002020C 85-102 IPB002020D 124-137 IPB002020E 187-233 IPB002020F 255-267 IPB002020G 325-341 IPB002020H 351-360","Residues 1-54 are 98% similar to a (SYNTHASE CITRATE LYASE ACID) protein domain (PD001913) which is seen in CISZ_STRMU.Residues 1-131 are 29% similar to a (SYNTHASE CITRATE LYASE COMPLETE) protein domain (PD309003) which is seen in Q9CHQ6_LACLA.Residues 174-363 are 99% similar to a (CITRATE LYASE SYNTHASE ACID CYCLE TRICARBOXYLIC ENZYME) protein domain (PD000990) which is seen in CISZ_STRMU.Residues 88-161 are identical to a (CITRATE SYNTHASE LYASE ACID) protein domain (PD003938) which is seen in CISZ_STRMU.Residues 103-167 are 41% similar to a (PROTEOME LYASE COMPLETE SYNTHASE) protein domain (PD389644) which is seen in Q9RWB2_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:01:51 2002","Thu Dec 13 15:54:57 2001","Fri Oct 11 14:01:51 2002","Thu Dec 13 15:54:57 2001","Thu Dec 13 15:54:57 2001","Thu Dec 13 15:54:57 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0613 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 13 15:57:54 2001","Thu Dec 13 15:54:57 2001","pdb|1AJ8|A Chain A, Citrate Synthase From Pyrococcus Furiosus >... 260 2e-070pdb|1A59| Cold-Active Citrate Synthase 254 2e-068pdb|6CSC|A Chain A, Chicken Citrate Synthase Complex With Trifl... 103 4e-023","SMU.671","","Residues 6 to 354 (E-value = 2.2e-145) place SMu0613 in the Citrate_synt family which is described as Citrate synthase (PF00285)","Thu Dec 13 15:54:57 2001","24379144","","Cvitkovitch,D.G., Gutierrez,J.A. and Bleiweis,A.S.Role of the citrate pathway in glutamate biosynthesis byStreptococcus mutansJ. Bacteriol. 179 (3), 650-655 (1997)PubMed: 9006016","Jin,S. and Sonenshein,A.L.Identification of two distinct Bacillus subtilis citrate synthasegenesJ. Bacteriol. 176 (15), 4669-4679 (1994)PubMed: 8045898","Wed Jan 23 12:38:35 2002","Wed Jan 23 12:39:27 2002","1","","","SMU.671","" "SMu0614","634632","635813","1182","ATGGCAGAAAAAGTAAGTTTTGAAGAAGGGAAATTACAGGTGCCTGATAAGCCCGTTATTCCTTACATTGAAGGAGATGGTGTTGGTCAGGATATTTGGAAGAATGCGCAAATCGTTTTTGATAAAGCCATTGCTAAAGTTTATGGAGGTCACAAGCAGGTTATTTGGCGGGAGGTCTTAGCTGGTAAAAAAGCTTATAATGAAACAGGCAACTGGCTGCCTAATGAGACTTTAGAAATTATCAAGACGCATTTACTTGCTATTAAAGGTCCATTGGAAACTCCTGTTGGAGGTGGCATTCGTTCCTTAAATGTTGCCCTGCGTCAAGAATTGGATCTCTTTGCTTGCGTGCGTCCAGTGCGTTATTTCAAAGGTGTCCCTAGTCCACTTAAGCATCCTGAAAAAACGGCTATTACCATTTTTCGAGAAAATACTGAAGATATTTACGCAGGTATCGAATGGAATGCGGGTACAGCAGAAGTTCAAAAGGTCATCAACTTTTTACAAGATGATATGCAGGTTAAGAAAATTCGTTTTCCAAAAAGCAGCAGTATAGGGATTAAACCTATTTCAATTGAAGGCAGCCAACGTTTGATTCGTGCAGCTATCGAATATGCTCTGGCCAACAATCTGACCAAGGTAACTTTGGTTCATAAAGGAAATATTCAAAAATTCACTGAAGGTGGCTTTAGAAAATGGGGCTATGAATTAGCAAAACGTGAGTATGCTGCCGAACTTGCCAGTGGTCAATTGGTAGTTGATGATATTATTGCTGACAATTTCTTGCAACAAATTCTGCTCAAGCCTGAGCGTTTTGATGTAGTTGCCTTAACGAATCTCAATGGAGACTATGCCAGCGATGCCTTAGCAGCACAAGTTGGCGGTATTGGTATTTCGCCAGGAGCTAATATTAACTATCAAACGGGACATGCTATTTTTGAAGCAACCCATGGAACGGCTCCAGATATTGCAGGTCAAGACTTGGCCAACCCATCTTCTGTTTTATTATCAGGCTGCATGCTTTTTGACTATATTGGTTGGTCAAAAGTCTCAGATTTAATCATGAAAGCTGTTGAAAAAGCTATTGCAAATGGTCAAGTTACCATTGATTTTGCCAAGGAACTAGGGGTTGAAGCATTGACAACCCGTCAGTTTTCTGAAGTTCTATTGACTTATTTATAG","6.30","-2.62","43128","MAEKVSFEEGKLQVPDKPVIPYIEGDGVGQDIWKNAQIVFDKAIAKVYGGHKQVIWREVLAGKKAYNETGNWLPNETLEIIKTHLLAIKGPLETPVGGGIRSLNVALRQELDLFACVRPVRYFKGVPSPLKHPEKTAITIFRENTEDIYAGIEWNAGTAEVQKVINFLQDDMQVKKIRFPKSSSIGIKPISIEGSQRLIRAAIEYALANNLTKVTLVHKGNIQKFTEGGFRKWGYELAKREYAAELASGQLVVDDIIADNFLQQILLKPERFDVVALTNLNGDYASDALAAQVGGIGISPGANINYQTGHAIFEATHGTAPDIAGQDLANPSSVLLSGCMLFDYIGWSKVSDLIMKAVEKAIANGQVTIDFAKELGVEALTTRQFSEVLLTYL","635810","For other 'cit' genes see SMu0612 (citB);SMu0613 (citZ); SMu0920 (citC); SMu0921 (citG);SMu0929 (citD); SMu0930 (citE); SMu0931 (citF) and SMu0932 (citX2). ","isocitrate dehydrogenase","Cytoplasm","Matches in gapped BLAST to isocitrate dehydrogenase:residues 1-393 are 95% similar to the previously published enzyme in S.mutans (gi|2497256|). Residues 1-393 are 69% similar to the protein from S.salivarius (gi|2497257|).Residues 3-390 are 56% similar to the protein from B.subtilis (gi|16079965|).SMu0614 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001804
Family

Isocitrate/isopropylmalate dehydrogenase
G3DSA:3.40.718.10	$\"[2-393]T$	IDH_IMDH
PTHR11835	$\"[43-381]T$	IDH_IMDH_dimeric
PF00180	$\"[19-389]T$	Iso_dh
PS00470	$\"[279-298]T$	IDH_IMDH

InterPro
IPR004439
Family

Isocitrate dehydrogenase NADP-dependent, prokaryotic
PTHR11835:SF1	$\"[43-381]T$	NADP_IDH_prok

noIPR
unintegrated

unintegrated
PIRSF000107	$\"[16-381]T$	3-IPM_dh
SSF53659	$\"[3-393]T$	SSF53659

","BeTs to 6 clades of COG0538COG name: Isocitrate dehydrogenasesFunctional Class: CThe phylogenetic pattern of COG0538 is a---Yqvcebr-uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001804 (Isocitrate and isopropylmalate dehydrogenases) with a combined E-value of 8.3e-38. IPB001804A 20-32 IPB001804B 137-151 IPB001804C 274-304 IPB001804D 317-344","Residues 196-337 are identical to a (DEHYDROGENASE OXIDOREDUCTASE NAD ISOCITRATE) protein domain (PD186037) which is seen in IDH_STRMU.Residues 340-389 are 98% similar to a (DEHYDROGENASE ISOCITRATE NADP) protein domain (PD035687) which is seen in IDH_STRMU.Residues 158-242 are 47% similar to a (PROTEOME ISOCITRATE COMPLETE) protein domain (PD396039) which is seen in Q9CHQ4_LACLA.Residues 156-179 are identical to a (ISOCITRATE DEHYDROGENASE NADP) protein domain (PD407892) which is seen in IDH_STRMU.Residues 95-154 are identical to a (DEHYDROGENASE NAD OXIDOREDUCTASE ISOCITRATE) protein domain (PD289641) which is seen in IDH_STRMU.Residues 4-86 are 98% similar to a (ISOCITRATE DEHYDROGENASE NADP) protein domain (PD000402) which is seen in IDH_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:02:33 2002","Thu Dec 13 16:20:04 2001","Fri Oct 11 14:02:33 2002","Thu Dec 13 16:18:23 2001","Thu Dec 13 16:18:23 2001","Thu Dec 13 16:18:23 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0614 is paralogously related (blast p-value < 1e-3) to SMu1261, a predicted 3-isopropylmalate dehydrogenase.","Wed Jan 23 12:45:14 2002","Thu Dec 13 16:18:23 2001","pdb|1ISO| Isocitrate Dehydrogenase: Structure Of An Engineer... 438 5e-124pdb|4ICD| Phosphorylated Isocitrate Dehydrogenase (E.C.1.1.1... 433 2e-122pdb|1BL5| Isocitrate Dehydrogenase From E. Coli Single Turno... 432 4e-122","SMU.672","","Residues 19 to 389 (E-value = 4.7e-124) place SMu0614 in the Iso_dh family which is described as Isocitrate/isopropylmalate dehydrogenase (PF00180)","Thu Dec 13 16:18:23 2001","24379145","","Cvitkovitch,D.G., Gutierrez,J.A. and Bleiweis,A.S.Role of the citrate pathway in glutamate biosynthesis byStreptococcus mutansJ. Bacteriol. 179 (3), 650-655 (1997)PubMed: 9006016Gutierrez JA, Crowley PJ, Brown DP, Hillman JD, Youngman P, Bleiweis ASInsertional mutagenesis and recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity and nutritional requirements.J Bacteriol 1996 Jul;178(14):4166-75 PubMed: 8763945PMID: 8763945","Jin,S. and Sonenshein,A.L.Identification of two distinct Bacillus subtilis citrate synthasegenesJ. Bacteriol. 176 (15), 4669-4679 (1994)PubMed: 8045898Singh,S.K., Matsuno,K., LaPorte,D.C. and Banaszak,L.J.Crystal structure of Bacillus subtilis isocitrate dehydrogenase at1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphataseJ. Biol. Chem. 276 (28), 26154-26163 (2001)PubMed: 11290745","Tue Mar 26 09:08:37 2002","Thu Dec 13 16:22:53 2001","1","","","SMU.672","" "SMu0615","636481","637278","798","ATGTGGTATTCTATATCGAATCTTGTTTTTCTCTTTTTTATCTATTCTTTTATCGGATGGCTTTGGGAGACAGTCTACTGTTCATTAAAAGATAAACAGTTTGTCTATCGTGGATTTTTAGCAGGGCCTTACTGTCCTGTTTATGGTTTTGCGGTAACAACTGTTTTGTTTTTGACGAAACCCTTTCAGGAAAATTTACCAATCTTATTTTTTGGCGGTCTTATTATTGCGACAGTTTTTGAATATATGGCGGCTTGCTTCTTGGAGAAGGTCTTTCATATGAAATTATGGGATTATAGCCAAGAATCAGGAAATATTAAAGGCCGAATTGCTCCTCGCATTTCTTTGTTTTGGGGAATTGGTGTTGTTTTTCTTGTGAAATTCATCCAGCCCTCAGTTATGCAGTTGTTGGCAAAGGTAAATGCTTGGTGGGCTTTGGGTATAGCCTTGTTTATGACAGCTGATTTTATTTGGACAGTGAGTGACTTAGCTAGCTTTCAGCGGGCAGCTTTATCTTTAGAGCGGAAAATGAGTGCGGAAGGTAAGGATATTCAGGCATATTTAAGAGAAATCTGGGGAAATTTGGAAGAAGAAACAGACTTTTTTTATCTGAGTCTCAGACAGTTTCATTTGCAAATTGAAAAGATGTTTCGAGAAAAAGGTATTCAGCCTTTTCGCTTCCATCAACGCCGCATGTTGCGCAATTACCACAAATTAAAACTCAAGGATGCCCCTTTTGTGGCAGCTGTTCATAAGCAGCTAGCTTCTGTAAAAAATAAAGATTTCAAAAAAAGGTAG","10.40","13.06","31199","MWYSISNLVFLFFIYSFIGWLWETVYCSLKDKQFVYRGFLAGPYCPVYGFAVTTVLFLTKPFQENLPILFFGGLIIATVFEYMAACFLEKVFHMKLWDYSQESGNIKGRIAPRISLFWGIGVVFLVKFIQPSVMQLLAKVNAWWALGIALFMTADFIWTVSDLASFQRAALSLERKMSAEGKDIQAYLREIWGNLEEETDFFYLSLRQFHLQIEKMFREKGIQPFRFHQRRMLRNYHKLKLKDAPFVAAVHKQLASVKNKDFKKR","637275","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein:residues 12-241 are 37% similar to an unknown protein in Lactococcus lactis subsp. lactis (gi|15673533|). SMu0615 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010540
Family

Protein of unknown function DUF1113
PF06541	$\"[9-242]T$	DUF1113

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 12-241 are 37% similar to a (PROTEOME COMPLETE) protein domain (PD400793) which is seen in Q9CFD0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 12:50:10 2002","Thu Dec 13 16:25:51 2001","Wed Jan 23 12:50:10 2002","Thu Dec 13 16:25:51 2001","","Thu Dec 13 16:25:51 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0615 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 23 12:50:10 2002","","No significant hits to the NCBI PDB database.","SMU.673","","Residues 9 to 242 (E-value = 1e-155) place SMu0615 in the DUF1113 family which is described as Protein of unknown function (DUF1113) (PF06541)","Thu Dec 13 16:25:51 2001","24379146","","","","","","1","","","SMU.673","" "SMu0616","637444","637707","264","ATGGCTTCAAAAGATTTTCACATTGTTGCAGAAACAGGAATTCATGCACGCCCAGCTACTTTGCTTGTTCAAACAGCAAGTAAGTTTGCCTCAGATATTACACTTGATTACAAAGGAAAAGCAGTAAACCTTAAGTCAATTATGGGTGTTATGAGCCTTGGTGTTGGTCAAGGTGCTGATGTTACAATCACTGCTGAAGGTGCAGATGCAGATGATGCAATTGCAGCTATTAATGAAACGATGACTAAAGAAGGATTGGCTTAA","4.70","-3.53","8919","MASKDFHIVAETGIHARPATLLVQTASKFASDITLDYKGKAVNLKSIMGVMSLGVGQGADVTITAEGADADDAIAAINETMTKEGLA","637704","From Genbank:[gi:1172720]This protein is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system.The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPR by enzyme I.Phospho-HPR then transfers it to the permease enzymes (II/III).HPR is common to all PTS.","phosphotransferase system phosphohistidine-containing protein","Cytoplasm","Matches in gapped BLAST to phosphotransferase system phosphohistidine-containing protein: residues 1-87 are 88%similar to the previously published enzyme in S.mutans (gi1172720).Residues 1-87 are 86% similar to the protein in S.pyogenes (gi15675305) and are 86% similar to the protein in S.bovis (gi13633635). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0821 (3e-37).","

InterPro
IPR000032
Family

Phosphotransferase system, phosphocarrier HPr protein
PD002238	$\"[9-87]T$	HPr_protein
PR00107	$\"[13-29]T$ $\"[38-53]T$ $\"[53-70]T$	PHOSPHOCPHPR
G3DSA:3.30.1340.10	$\"[1-85]T$	PTS_HPr_protein
PF00381	$\"[1-84]T$	PTS-HPr
SSF55594	$\"[1-84]T$	HPr_protein

InterPro
IPR001020
PTM

Phosphotransferase system, HPr histidine phosphorylation site
PS00369	$\"[13-20]T$	PTS_HPR_HIS

InterPro
IPR002114
PTM

Phosphotransferase system, HPr serine phosphorylation site
PS00589	$\"[39-54]T$	PTS_HPR_SER

","BeTs to 6 clades of COG1925COG name: Phosphotransferase system, HPr-related proteinsFunctional Class: GThe phylogenetic pattern of COG1925 is --------EB-H--gpOlin-Number of proteins in this genome belonging to this COG is 1","***** IPB001020 (Histidine phosphorylation site in HPr protein) with a combined E-value of 3.2e-49. IPB001020A 8-35 IPB001020B 39-77***** PR00107 (Phosphocarrier protein signature) with a combined E-value of 1.5e-38. PR00107A 13-29 PR00107B 38-53 PR00107C 53-70***** IPB002114 (Serine phosphorylation site in HPr protein) with a combined E-value of 4.1e-11. IPB002114A 2-32 IPB002114B 44-87","Residues 1-67 are identical to a (PHOSPHOTRANSFERASE HPR SYSTEM PHOSPHOCARRIER) protein domain (PD002238) which is seen in PTHP_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:01:05 2002","Thu Dec 13 16:27:21 2001","Fri Jul 7 17:06:16 2006","Thu Dec 13 16:27:21 2001","Thu Dec 13 16:27:21 2001","Thu Dec 13 16:27:21 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0616 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 13 16:31:37 2001","Fri Jul 7 17:06:16 2006","pdb1PTF Histidine-Containing Phosphocarrier Protein (Hpr) 126 5e-031pdb1FU0A Chain A, Crystal Structure Analysis Of The Phospho-S... 125 1e-030pdb1SPHA Chain A, Phosphocarrier Protein (Hpr, Histidine-Cont... 104 3e-024","SMU.674","","Residues 1 to 84 (E-value = 5.2e-54) place SMu0616 in the PTS-HPr family which is described as PTS HPr component phosphorylation site (PF00381)","Thu Dec 13 16:27:21 2001","24379147","","Boyd,D.A., Cvitkovitch,D.G. and Hamilton,I.R.Sequence and expression of the genes for HPr (ptsH) and enzyme I(ptsI) of the phosphoenolpyruvate-dependent phosphotransferasetransport system from Streptococcus mutansInfect. Immun. 62 (4), 1156-1165 (1994)PubMed: 8132321Dashper,S.G., Kirszbaum,L., Huq,N.L., Riley,P.F. and Reynolds,E.C.Complete amino acid sequence and comparative molecular modelling of HPr from Streptococcus mutans IngbrittBiochem. Biophys. Res. Commun. 199 (3), 1297-1304 (1994)PubMed: 8147873Boyd DA, Cvitkovitch DG, Hamilton IRSequence, expression, and function of the gene for the nonphosphorylating, NADP-dependent glyceraldehyde-3-phosphatedehydrogenase of Streptococcus mutans.J Bacteriol 1995 May;177(10):2622-7 PubMed: 7751269PMID: 7751269","Gagnon,G., Vadeboncoeur,C. and Frenette,M.Phosphotransferase system of Streptococcus salivarius:characterization of the ptsH gene and its productGene 136 (1-2), 27-34 (1993)PubMed: 8294015Vadeboncoeur,C., Konishi,Y., Dumas,F., Gauthier,L. and Frenette,M.HPr polymorphism in oral streptococci is caused by the partialremoval of the N-terminal methionineBiochimie 73 (11), 1427-1430 (1991)PubMed: 1799636","Tue Mar 26 09:11:59 2002","Thu Dec 13 16:34:49 2001","1","","","SMU.674","786" "SMu0617","637712","639445","1734","ATGACAGAAATGCTTAAAGGAATTGCAGCATCTGATGGTGTTGCTGTTGCTAAGGCATATCTACTTGTTCAACCGGACTTAACATTTGAGACTGTTTCAGTCACAGATACACAAGCAGAAGAGGCTCGTTTGGATGCAGCTCTAGAAGCTTCTCAAAACGAGCTTTCTCTTATCCGCCAAAAAGCAGTAGATACCCTTGGTGAAGAAGCCGCAGCTGTATTTGATGCTCATTTGATGGTTCTTGCTGACCCAGAGATGATTGGGCAGATTAAAGAGACAATTCGTACAAAAGAAGTTAATGCAGAAAGTGCTCTCAAAGAAGTGACAGATATGTTTGTTACTTTGTTTGAAAATATGGAAGACAACCCCTATATGCAAGAGCGTGCTGCAGATATTCGTGACGTTGCCAAGCGTGTTTTGGCACACCTTCTGGGTGTTGAATTGCCAAACCCAGCAACGATTAGTGAAGAATCTATTGTAATTGCTCATGACTTAACGCCATCTGATACGGCTCAATTGGATGCTAACTATGTTAAAGCTTTTGTGACGAATATTGGTGGACGCACAAGTCATTCTGCTATTATGGCACGTACACTTGAAATCGCTGCTGTACTTGGTACAAATGATATTACAGAGCGTGTGAAAAATGGTGATATTGTTGCCGTCAATGGAATTACTGGTCAAGTGATTATTAATCCAACTGAAGATCAAATTGCAGAGTTCAAAGCAGCTGGTGAGACTTATGCTAAGCAAAAAGCAGAATGGGCTCTCCTTAAGGATGCTGAAACGGTTACTGCTGATGGTAAGCACTTTGAATTGGCAGCCAATATTGGTACACCTAAAGACGTTGAGGGTGTCAATAACAATGGTGCTGAAGCAGTTGGCCTCTATCGTACAGAATTTCTATACATGGATTCGCAAGATTTTCCAACTGAAGATGAACAATATGAAGCTTATAAAGCTGTTCTTGAAGGTATGAATGGTAAGCCGGTTGTTGTCCGCACGATGGATATTGGTGGTGATAAGGAACTTCCTTACTTTGATCTTCCAAAAGAAATGAACCCATTCCTTGGTTTTCGTGCACTTCGTATTTCAATCTCAGAAACAGGTAATCAGATGTTCCGCACACAGTTGCGTGCCCTTTTGCGTGCTTCTGTTCATGGTCAGTTGCGTATCATGTTCCCAATGGTAGCTTTGCTCAATGAGTTCCGTAAAGCTAAAGGTATTCTGGAAGAAGAAAAGGCTAATCTTAAAGCTGAAGGTGTTGCTGTTTCAGATGATATCCAAGTTGGTATCATGATTGAAATTCCTGCAGCTGCAATGCTGGCTGACCAATTTGCTAAGGAAGTTGATTTCTTCTCAATCGGTACAAATGACCTTATTCAATACACCATGGCTGCTGACCGTATGAATGAACAAGTATCATATCTCTACCAACCTTATAATCCATCCATTCTTCGCTTGGTTGATCATGTGGTTAAGGCTGCTCATGCTGAAGGTAAATGGGCTGGTATGTGCGGTGAGATGGCTGGCGATCAGACAGCAGTTCCCCTTCTTGTTGGTATTGGACTTGATGAGTTCTCTATGTCTGCAACATCGGTTCTCCGTACACGCAGTCTTATGAAGAAATTAGATACTGATAAAATGCAAGAACTTGCTCAGCGTGCTCTGACAGAATGTGCAACGATGGAAGAAGTTCTTGAGTTAGAAAAAGAATATATTGATTTTGACTAA","4.40","-39.08","63390","MTEMLKGIAASDGVAVAKAYLLVQPDLTFETVSVTDTQAEEARLDAALEASQNELSLIRQKAVDTLGEEAAAVFDAHLMVLADPEMIGQIKETIRTKEVNAESALKEVTDMFVTLFENMEDNPYMQERAADIRDVAKRVLAHLLGVELPNPATISEESIVIAHDLTPSDTAQLDANYVKAFVTNIGGRTSHSAIMARTLEIAAVLGTNDITERVKNGDIVAVNGITGQVIINPTEDQIAEFKAAGETYAKQKAEWALLKDAETVTADGKHFELAANIGTPKDVEGVNNNGAEAVGLYRTEFLYMDSQDFPTEDEQYEAYKAVLEGMNGKPVVVRTMDIGGDKELPYFDLPKEMNPFLGFRALRISISETGNQMFRTQLRALLRASVHGQLRIMFPMVALLNEFRKAKGILEEEKANLKAEGVAVSDDIQVGIMIEIPAAAMLADQFAKEVDFFSIGTNDLIQYTMAADRMNEQVSYLYQPYNPSILRLVDHVVKAAHAEGKWAGMCGEMAGDQTAVPLLVGIGLDEFSMSATSVLRTRSLMKKLDTDKMQELAQRALTECATMEEVLELEKEYIDFD","639442","For other 'pts' genes see SMu0685 (ptsK) and SMu1858 (ptsG).Ajdic et al., 2002, describe this protein as a \"non-specific energy coupling component.\"","phosphoenolpyruvate-protein phosphotransferase (enzyme I)","Cytoplasm","Matches in gapped BLAST to phosphoenolpyruvate-protein phosphotransferase : residues 1-577 are 97% similar to the previously published enzyme in S.mutans (gi|1172702|).Residues 1-577 are 87% similar to the protein from S.bovis (gi|4958916|) and from S.salivarius (gi|266857|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0822 (0.0).","

InterPro
IPR000121
Domain

PEP-utilizing enzyme
PD000940	$\"[275-534]T$	PEP_utilizers
PF02896	$\"[252-546]T$	PEP-utilizers_C
PS00742	$\"[451-469]T$	PEP_ENZYMES_2

InterPro
IPR006318
Domain

Phosphoenolpyruvate-protein phosphotransferase
PR01736	$\"[295-314]T$ $\"[451-466]T$ $\"[468-483]T$ $\"[504-516]T$	PHPHTRNFRASE
TIGR01417	$\"[5-571]T$	PTS_I_fam

InterPro
IPR008279
Domain

PEP-utilising enzyme, mobile region
PF00391	$\"[147-227]T$	PEP-utilizers
PS00370	$\"[186-197]T$	PEP_ENZYMES_PHOS_SITE
SSF52009	$\"[127-251]T$	PEP_mobile

InterPro
IPR008731
Domain

phosphotransferase system, PEP-utilising enzyme, N-terminal
PF05524	$\"[5-129]T$	PEP-utilisers_N
SSF47831	$\"[23-146]T$	PEP-utilisers_N

noIPR
unintegrated

unintegrated
G3DSA:1.10.274.10	$\"[22-148]T$	G3DSA:1.10.274.10
G3DSA:3.20.20.60	$\"[252-575]T$	G3DSA:3.20.20.60
PTHR22931	$\"[4-569]T$	PTHR22931
PTHR22931:SF10	$\"[4-569]T$	PTHR22931:SF10
SSF51621	$\"[250-554]T$	SSF51621

","BeTs to 5 clades of COG1080COG name: Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)Functional Class: GThe phylogenetic pattern of COG1080 is --------Eb-h--gpo-in-Number of proteins in this genome belonging to this COG is 1","***** IPB000121 (PEP-utilizing enzyme) with a combined E-value of 1e-82. IPB000121A 77-87 IPB000121B 180-206 IPB000121C 290-302 IPB000121D 352-363 IPB000121E 392-402 IPB000121F 435-471 IPB000121G 500-513***** IPB002192 (Pyruvate phosphate dikinase, PEP/pyruvate binding domain) with a combined E-value of 8e-43. IPB002192E 180-206 IPB002192F 223-232 IPB002192G 272-303 IPB002192I 352-361 IPB002192J 377-402 IPB002192K 437-471 IPB002192L 500-517***** IPB002114 (Serine phosphorylation site in HPr protein) with a combined E-value of 1.5e-09. IPB002114B 500-543","Residues 1-149 are 91% similar to a (PHOSPHOTRANSFERASE SYSTEM ENZYME I) protein domain (PD190342) which is seen in PT1_STRMU.Residues 1-139 are 28% similar to a (PHOSPHOTRANSFERASE I SYSTEM ENZYME) protein domain (PD178075) which is seen in Q9PDH7_XYLFA.Residues 509-574 are 98% similar to a (PHOSPHOTRANSFERASE SYSTEM I ENZYME) protein domain (PD003206) which is seen in PT1_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 20:34:26 2002","Sun Oct 27 20:34:26 2002","Sun Oct 27 20:34:26 2002","Thu Dec 13 16:37:40 2001","Thu Dec 13 16:37:40 2001","Thu Dec 13 16:37:40 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0617 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 13 16:39:47 2001","Thu Dec 13 16:37:40 2001","pdb|1EZA| Amino Terminal Domain Of Enzyme I From Escherichia... 195 1e-050pdb|1ZYM|B Chain B, Amino Terminal Domain Of Enzyme I From Esch... 195 1e-050pdb|3EZA|A Chain A, Complex Of The Amino Terminal Domain Of Enz... 184 3e-047","SMU.675","","Residues 5 to 129 (E-value = 3.7e-62) place SMu0617 in the PEP-utilisers_N family which is described as PEP-utilising enzyme, N-terminal (PF05524)Residues 146 to 227 (E-value = 8.5e-40) place SMu0617 in the PEP-utilizers family which is described as PEP-utilising enzyme, mobile domain (PF00391)Residues 252 to 546 (E-value = 3.7e-202) place SMu0617 in the PEP-utilizers_C family which is described as PEP-utilising enzyme, TIM barrel domain (PF02896)","Thu Dec 13 16:37:40 2001","24379148","","Boyd,D.A., Cvitkovitch,D.G. and Hamilton,I.R.Sequence and expression of the genes for HPr (ptsH) and enzyme I(ptsI) of the phosphoenolpyruvate-dependent phosphotransferasetransport system from Streptococcus mutansInfect. Immun. 62 (4), 1156-1165 (1994)PubMed: 8132321Boyd,D.A., Cvitkovitch,D.G. and Hamilton,I.R.Sequence, expression, and function of the gene for thenonphosphorylating, NADP-dependent glyceraldehyde-3-phosphatedehydrogenase of Streptococcus mutansJ. Bacteriol. 177 (10), 2622-2627 (1995)PubMed: 7751269","Gagnon,G., Vadeboncoeur,C., Levesque,R.C. and Frenette,M.Cloning, sequencing and expression in Escherichia coli of the ptsIgene encoding enzyme I of the phosphoenolpyruvate:sugarphosphotransferase transport system from Streptococcus salivariusGene 121 (1), 71-78 (1992)PubMed: 1427100Gagnon,G., Vadeboncoeur,C. and Frenette,M.Phosphotransferase system of Streptococcus salivarius:characterization of the ptsH gene and its productGene 136 (1-2), 27-34 (1993)PubMed: 8294015","Wed Jan 23 12:57:34 2002","Thu Dec 13 16:42:19 2001","1","","","SMU.675","89" "SMu0618","639675","641102","1428","TTGACAAAACAATATAAAAATTATGTCAATGGCGAGTGGAAGCTTTCAGAAAATGAAATTAAAATCTACGAACCGGCCAGTGGAGCTGAATTGGGTTCAGTTCCAGCAATGAGTACTGAAGAAGTAGATTATGTTTATGCTTCAGCCAAGAAAGCTCAACCAGCTTGGCGATCACTTTCATACATAGAACGTGCTGCCTACCTTCATAAGGTAGCAGATATTTTGATGCGTGATAAAGAAAAAATAGGTGCTGTTCTTTCCAAAGAGGTTGCTAAAGGTTATAAATCAGCAGTCAGCGAAGTTGTTCGTACTGCAGAAATCATTAATTATGCAGCTGAAGAAGGCCTTCGTATGGAAGGTGAAGTCCTTGAAGGCGGCAGTTTTGAAGCAGCCAGCAAGAAAAAAATTGCCGTTGTTCGTCGTGAACCAGTAGGTCTTGTATTAGCTATTTCACCATTTAACTACCCTGTTAACTTGGCAGGTTCGAAAATTGCACCGGCTCTTATTGCGGGAAATGTTATTGCTTTTAAACCACCGACGCAAGGATCAATCTCAGGGCTCTTACTTGCTGAAGCATTTGCTGAAGCTGGACTTCCTGCAGGTGTCTTTAATACCATTACAGGTCGTGGTTCTGAAATTGGAGACTATATTGTAGAACATCAAGCCGTTAACTTTATCAATTTCACTGGTTCAACAGGAATTGGGGAACGTATTGGCAAAATGGCTGGTATGCGTCCGATTATGCTTGAACTCGGTGGAAAAGATTCAGCCATCGTTCTTGAAGATGCAGACCTTGAATTGACTGCTAAAAATATTATTGCAGGTGCTTTTGGTTATTCAGGTCAACGCTGTACAGCAGTTAAACGTGTTCTTGTGATGGAAAGTGTTGCTGATGAACTGGTCGAAAAAATCCGTGAAAAAGTTCTTGCATTAACAATTGGTAATCCAGAAGACGATGCAGATATTACACCGTTGATTGATACAAAATCAGCTGATTATGTAGAAGGTCTTATTAATGATGCCAATGATAAAGGAGCCGCTGCCCTTACTGAAATCAAACGTGAAGGTAATCTTATCTGTCCAATCCTCTTTGATAAGGTAACGACAGATATGCGTCTTGCTTGGGAAGAACCATTTGGTCCTGTTCTTCCGATCATTCGTGTGACATCTGTAGAAGAAGCCATTGAAATTTCTAACAAATCGGAATATGGACTTCAGGCTTCTATCTTTACAAATGATTTCCCACGCGCTTTTGGTATTGCTGAGCAGCTTGAAGTTGGTACAGTTCATATCAATAATAAGACACAGCGCGGTACGGACAACTTCCCATTCTTAGGGGCTAAAAAATCAGGTGCAGGTATTCAAGGGGTAAAATATTCTATTGAAGCTATGACAACTGTTAAATCCGTCGTATTTGATATCAAATAA","4.90","-11.31","51165","MTKQYKNYVNGEWKLSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKKAQPAWRSLSYIERAAYLHKVADILMRDKEKIGAVLSKEVAKGYKSAVSEVVRTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKIAVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMAGMRPIMLELGGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADELVEKIREKVLALTIGNPEDDADITPLIDTKSADYVEGLINDANDKGAAALTEIKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTNDFPRAFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVVFDIK","641099","For other 'gap' genes see SMu0325 (gapC),(gapdh).From Genbank: [gi:2494077]This enzyme plays an important role as a means of generating NADPH for biosynthetic reactions.","NADP-dependent non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase","Cytoplasm","Matches in gapped BLAST to NADP-dependent glyceraldehyde-3-phosphate dehydrogenase:residues 1-475 are 95%similar to the previously published enzyme in S.mutans (gi2494077). Residues 1-475 are 81% similar to the protein from S.pyogenes (gi15675303).Residues 4-475 are 70% similar to the protein fromS.pneumoniae (gi15900986).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0823 (0.0).","

InterPro
IPR002086
Domain

Aldehyde dehydrogenase
PF00171	$\"[13-470]T$	Aldedh
PS00070	$\"[277-288]?$	ALDEHYDE_DEHYDR_CYS

InterPro
IPR012303
Family

NAD-dependent aldehyde dehydrogenase
PIRSF000147	$\"[19-475]T$	NAD-dependent aldehyde dehydrogenase

InterPro
IPR015590
Domain

Aldehyde Dehydrogenase_
PTHR11699	$\"[47-475]T$	ALDEHYDE DEHYDROGENASE-RELATED

noIPR
unintegrated

unintegrated
G3DSA:3.40.605.10	$\"[4-292]T$	no description
PTHR11699:SF29	$\"[47-475]T$	NADP-DEPENDENT GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE

","BeTs to 9 clades of COG1012COG name: NAD-dependent aldehyde dehydrogenasesFunctional Class: CThe phylogenetic pattern of COG1012 is -mt-Yq-CEBR-uj-------Number of proteins in this genome belonging to this COG is 3","***** IPB002086 (Aldehyde dehydrogenase family) with a combined E-value of 9.8e-70. IPB002086A 143-156 IPB002086B 197-214 IPB002086C 223-243 IPB002086D 255-298 IPB002086E 358-411 IPB002086F 433-457","Residues 392-456 are 49% similar to a (DEHYDROGENASE PROTEOME COMPLETE OXIDOREDUCTASE PROLINE) protein domain (PD000187) which is seen in Q9ZUG8_ARATH.Residues 5-72 are 98% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE NAD COMPLETE) protein domain (PD000378) which is seen in GAPN_STRMU.Residues 4-72 are 34% similar to a (A PROTEOME COMPLETE DEHYDROGENASE) protein domain (PD352913) which is seen in Q9JW97_NEIMA.Residues 320-390 are 98% similar to a (DEHYDROGENASE GLYCERALDEHYDE-3-PHOSPHATE) protein domain (PD384377) which is seen in GAPN_STRMU.Residues 391-470 are identical to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE NAD PROTEOME) protein domain (PD284668) which is seen in GAPN_STRMU.Residues 324-386 are 46% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE) protein domain (PD391678) which is seen in SSDH_RAT.Residues 9-460 are 21% similar to a (DEHYDROGENASE FIS1 NAD OXIDOREDUCTASE) protein domain (PD144799) which is seen in Q9FJJ2_ARATH.Residues 149-215 are 76% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE NAD PROTEOME) protein domain (PD334899) which is seen in GAPN_STRMU.Residues 393-451 are 71% similar to a (DEHYDROGENASE NAD OXIDOREDUCTASE ALDEHYDE) protein domain (PD389567) which is seen in Q9KAQ0_BACHD.Residues 75-145 are 98% similar to a (DEHYDROGENASE COMPLETE PROTEOME OXIDOREDUCTASE ALDEHYDE) protein domain (PD000314) which is seen in GAPN_STRMU.Residues 217-319 are identical to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD000218) which is seen in GAPN_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 09:57:08 2006","Fri Oct 25 13:15:35 2002","Tue Aug 1 09:57:08 2006","Thu Dec 13 16:47:10 2001","Thu Dec 13 16:47:10 2001","Thu Dec 13 16:47:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0618 is paralogously related (blast p-value < 1e-3) to SMu1930,a predicted succinic semialdehyde dehydrogenase (NAD-dependent aldehyde dehydrogenase), and SMu0408,a predicted gamma-glutamyl phosphate reductase .","Wed Jan 23 13:07:04 2002","Tue Aug 1 09:57:08 2006","pdb1QI6A Chain A, Second Apo Form Of An Nadp Dependent Aldehy... 892 0.0pdb1QI1A Chain A, Ternary Complex Of An Nadp Dependent Aldehy... 888 0.0pdb1BI9D Chain D, Retinal Dehydrogenase Type Two With Nad Bou... 219 6e-058","SMU.676","","Residues 13 to 474 (E-value = 3.2e-134) place SMu0618 in the Aldedh family which is described as Aldehyde dehydrogenase family (PF00171)","Thu Dec 13 16:47:10 2001","24379149","","Marchal S, Branlant G. Characterization of the Amino Acids Involved in Substrate Specificity of Nonphosphorylating Glyceraldehyde-3-Phosphate Dehydrogenase from Streptococcus mutans.J Biol Chem. 2002 Oct 18;277(42):39235-42.PMID: 12163495Marchal S, Branlant G. Engineered nonphosphorylating glyceraldehyde 3-phosphate dehydrogenase at position 268 binds hydroxylamine and hydrazine as acyl acceptors.Eur J Biochem. 2001 Nov;268(22):5764-70.PMID: 11722561 Tao L, Tanzer JM.Novel sucrose-dependent adhesion co-factors in Streptococcus mutans.J Dent Res. 2002 Jul;81(7):505-10.PMID: 12161466 Boyd,D.A., Cvitkovitch,D.G. and Hamilton,I.R.Sequence, expression, and function of the gene for thenonphosphorylating, NADP-dependent glyceraldehyde-3-phosphatedehydrogenase of Streptococcus mutansJ. Bacteriol. 177 (10), 2622-2627 (1995)PubMed: 7751269Cobessi D, Tete-Favier F, Marchal S, Azza S, Branlant G, Aubry AApo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.J Mol Biol 1999 Jul 2;290(1):161-73PubMed: 10388564PMID: 10388564Cobessi D, Tete-Favier F, Marchal S, Branlant G, Aubry AStructural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase fromStreptococcus mutans.J Mol Biol 2000 Jun 30;300(1):141-52 PubMed: 10864505PMID: 10864505","Brunner NA, Siebers B, Hensel R.Role of two different glyceraldehyde-3-phosphate dehydrogenases in controlling the reversible Embden-Meyerhof-Parnas pathway in Thermoproteus tenax: regulation on protein and transcript level.Extremophiles. 2001 Apr;5(2):101-9.PMID: 11354453 ","Sat Oct 26 17:07:00 2002","Wed Jan 23 13:12:02 2002","1","","","SMU.676","90" "SMu0619","641773","642165","393","ATGAATATTAAAAAAGTAAGTGAAATAACTGACATATCAGCGGATACTATTCGTTATTATGAGCGTATTGGTCTTTTGCCGCGAATTACAAGAACAAATTCCGGCGTTCGTGATTTCACAGAGCGTGAGATTGGTATTTTGGAATTTGTCCGCTGTTTTCGTAAGGCTGGCATGAGTGTTGAAGCCTTGATTGAATACATTTCTCTCTTAGAAGAAGGAGAAGGTACAGAAAGAGAACGGCTGCGTTTACTAACGGAACAGCGTGATGAAATGGATGATCGTATTTACGAACTTAATCAAGCGCGTGAACGTCTCAATTACAAAATTGAAAATTATGAAAATATTATTCAAAAGCATGAACAGAAATTGTTCACAGAAAGTGAGGAAAACTAA","4.80","-6.79","15551","MNIKKVSEITDISADTIRYYERIGLLPRITRTNSGVRDFTEREIGILEFVRCFRKAGMSVEALIEYISLLEEGEGTERERLRLLTEQRDEMDDRIYELNQARERLNYKIENYENIIQKHEQKLFTESEEN","642162","For other 'rme' genes see SMu1918 (rmeD). ","transcriptional regulator, MerR family","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator: residues 1-113 are 44% similar to the protein in S.pneumoniae (gi|15901684|).Residues 1-123 are 40% similar to the protein from Clostridium acetobutylicum (gi|15894053|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0427 (9e-30).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PR00040	$\"[13-26]T$ $\"[37-57]T$	HTHMERR
PF00376	$\"[2-39]T$	MerR
SM00422	$\"[1-70]T$	HTH_MERR
PS50937	$\"[1-69]T$	HTH_MERR_2

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[1-119]T$	Putativ_DNA_bind

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[1-114]T$	G3DSA:1.10.1660.10

","BeTs to 7 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 6.2e-20. IPB000551A 3-24 IPB000551B 26-67","Residues 5-39 are 62% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REGULATOR) protein domain (PD000861) which is seen in Q9CEG4_LACLA.Residues 43-120 are 28% similar to a (REGULATOR PROTEOME TRANSCRIPTIONAL) protein domain (PD072156) which is seen in O06008_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:11:39 2002","Thu Dec 13 16:57:07 2001","Fri Oct 11 14:11:39 2002","Thu Dec 13 16:56:34 2001","Thu Dec 13 16:56:34 2001","Thu Dec 13 16:56:34 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0619 is paralogously related (blast p-value < 1e-3) to SMu1918, SMu0144, SMu1630, SMu0477, and SMu1868, all possible transcriptional regulators.","Wed Jan 23 13:14:27 2002","","No significant hits to the NCBI PDB database.","SMU.677","","Residues 2 to 39 (E-value = 6e-10) place SMu0619 in the MerR family which is described as MerR family regulatory protein (PF00376)","Thu Dec 13 16:56:34 2001","24379150","","","","","","1","","","SMU.677","" "SMu0620","642165","643007","843","ATGGAAACTGTAGTCTTATCAAATGGTGTGAAAATGCCTATCTTAGGTTTTGGTGTTTTTCAAGTGCCTGATCTGGAAGAATGTGAGCGTGTAGTGACTGAAGCTATTAAGGTGGGCTATCGTCTCCTTGATACAGCACAAGTCTATGGCAATGAGGAGGCCGTTGGAAATGCAGTGCGCAAATCAGGTCTGGCTCGGGAAGAATTCTTCATTACAACCAAGGTCTGGATTTCTAATGCGGGCTATGAAAAAGCTAAAGCTTCTCTAGATGAATCGCTGCGCAAATTGCAGACAGACTATGTCGACTTGGTGCTCATTCATCAACCTTTTGGCGATTACTATGGTACTTGGAGTGCTCTGGAAGCATACTATAAATCCGGCAAAATCAAAGCCATCGGTGTCAGTAATTTTTACCCAGATCGTTTAGTAGATTTGGCAAGCTTTAATGAGATTGTACCTATGGTCAACCAAGTCGAAACCCATGTTTTTAATCAACAGATTGAAGCTAAAAAGGTCAGTGAGGAATACGGTGTTCAGCTGGAATCTTGGGGACCTTTTGCAGAAGGTAAAAATAATTTCTTTACTAATCCAACTTTAACAGCTATTGGTGAAAAGTATGGGAAATCTGCTGCTCAGGTTGGTCTGCGCTATCTTATCCAGCGTGGCGTTGTTGTCATTCCAAAGACGGTCCATCAAGAGCGTATGGTACAAAATTTTGATGTCTTTGGCTTCAATTTGTCCGACGATGATATGGCAGACATTTTGAAATTGGACCAAGGTGAAAGTCTCTTTATCAACCATTACGATCCTGAAACTGTTAAGTTTCTGGCAAATTATAAATAG","4.90","-9.06","31541","METVVLSNGVKMPILGFGVFQVPDLEECERVVTEAIKVGYRLLDTAQVYGNEEAVGNAVRKSGLAREEFFITTKVWISNAGYEKAKASLDESLRKLQTDYVDLVLIHQPFGDYYGTWSALEAYYKSGKIKAIGVSNFYPDRLVDLASFNEIVPMVNQVETHVFNQQIEAKKVSEEYGVQLESWGPFAEGKNNFFTNPTLTAIGEKYGKSAAQVGLRYLIQRGVVVIPKTVHQERMVQNFDVFGFNLSDDDMADILKLDQGESLFINHYDPETVKFLANYK","643004","","oxidoreductase, aldo/keto reductase family","Cytoplasm","Several matches in gapped BLAST to oxidoreductase, aldo/keto reductase family: residues 1-280 are 55% similar to the enzyme in Listeria monocytogenes (gi|16804630|).Residues 4-280 are 55% similar to the enzyme in Thermotoga maritima (gi|15643767|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1476 (4e-63).","

InterPro
IPR001395
Family

Aldo/keto reductase
PD000288	$\"[5-258]T$	Aldo/ket_red
PR00069	$\"[35-59]T$ $\"[91-109]T$ $\"[120-137]T$ $\"[154-183]T$ $\"[193-217]T$	ALDKETRDTASE
G3DSA:3.20.20.100	$\"[3-263]T$	Aldo/ket_red
PTHR11732	$\"[1-230]T$	Aldo/ket_red
PF00248	$\"[6-259]T$	Aldo_ket_red
PS00062	$\"[120-137]T$	ALDOKETO_REDUCTASE_2
PS00063	$\"[226-241]T$	ALDOKETO_REDUCTASE_3
PS00798	$\"[39-56]T$	ALDOKETO_REDUCTASE_1

noIPR
unintegrated

unintegrated
PTHR11732:SF34	$\"[1-230]T$	PTHR11732:SF34
SSF51430	$\"[1-280]T$	SSF51430

","BeTs to 7 clades of COG0656COG name: Aldo/keto reductases, related to diketogulonate reductaseFunctional Class: RThe phylogenetic pattern of COG0656 is ---kY-VcEBr----------Number of proteins in this genome belonging to this COG is 3","***** IPB001395 (Aldo/keto reductase family) with a combined E-value of 2.7e-65. IPB001395A 6-17 IPB001395B 35-54 IPB001395C 64-76 IPB001395D 98-109 IPB001395E 150-187 IPB001395F 206-251","Residues 10-260 are 55% similar to a (OXIDOREDUCTASE PROTEOME CHANNEL COMPLETE DEHYDROGENASE) protein domain (PD000288) which is seen in Q9X0A2_THEMA.Residues 9-107 are 34% similar to a (COMPLETE PROTEOME RELATED NDP-HEXOSE) protein domain (PD274380) which is seen in Q9X123_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 15 12:45:09 2002","Fri Oct 11 14:13:12 2002","Fri Oct 11 14:13:12 2002","Thu Dec 13 17:10:12 2001","Thu Dec 13 17:10:12 2001","Thu Dec 13 17:10:12 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0620 is paralogously related (blast p-value < 1e-3) to SMu0621, SMu0761, and SMu0345, all predicted oxidoreductases, aldo/ketoreductase family.","Tue Jan 15 12:45:09 2002","Thu Dec 13 17:10:12 2001","pdb|1A80| Native 2,5-Diketo-D-Gluconic Acid Reductase A From... 208 8e-055pdb|2ALR| Aldehyde Reductase 156 3e-039pdb|1EKO|A Chain A, Pig Aldose Reductase Complexed With Idd384 ... 152 5e-038","SMU.678","","Residues 6 to 259 (E-value = 1.2e-105) place SMu0620 in the Aldo_ket_red family which is described as Aldo/keto reductase family (PF00248)","Thu Dec 13 17:10:12 2001","24379151","","","Samaras,N. and Spithill,T.W. The developmentally regulated P100/11E gene of Leishmania major shows homology to a superfamily of reductase genes J. Biol. Chem. 264 (7), 4251-4254 (1989) PubMed: 2918000","","Tue Jan 15 12:45:44 2002","1","","","SMU.678","" "SMu0621","643017","643883","867","ATGGAATATATAACCTTAAATACAGGTGTAAAAATGCCCATGGAAGGATTCGGTGTTTTTCAGGTGACTGATCCAGAAATTTGTAAGGAATCTGTGCTTAATGCTATCAAAACAGGTTACCGTCTCTTTGATACAGCGGCTGTCTATGGTAATGAAAAAGCATTGGGAGAAGCAATCCATGAAGCCATTGAGCAAGGTTTGGTGACGCGAAATGAGCTTTTTATCACCTCAAAACTTTGGGTACAGGATATGAATTATGAGGCTGCTAAGAAGGGTATTGAGCGTTCTTTAGAAAAACTTGGTTTGGATTATCTTGACTTGTATCTCTTGCATCAAGCCATGCGCGATTATTTTGGTGCTTATCGTGCTCTGGAAGAAGCCTATCAGGCAGGCAAGCTCAGAGCTATCGGCGTCAGCAATTTTTATCCTAATATTTTGACGAATTTCTGTGAAACGGTGTCGGTTATTCCAGCAGTCAATCAAATTGAATTGCATCCATTCTTTACTCAAGAAGAAGCTTTGGAGACTGCTCGTTATTATGGTGTTGTGCCAGAAGCATGGGCGCCTTTAGGCGGTGGACGTTATGACGCTTTTAATAATGCTATTTTGCAGGAAGTTGCTAGCGCTCATCAAAAAACTGTTGGACAGATCATGTTGCGCTGGAATGTTCAACGCGGTGTCGTTGTTATTCCAAAATCAACCCACAAAGAGCGTATTGAAGAGAATTTCGCTATTTGGGATTTCAGCCTAACAGACGATGAGATGACCAAAATAGCTTCGCTGGATATGGGTTATGGAGATACGCGAACAAAACATTTCGATCCCAATTTTGTCAGAAGTGTTCTCAATGTTAAAATTCATGATTAA","5.10","-9.39","32652","MEYITLNTGVKMPMEGFGVFQVTDPEICKESVLNAIKTGYRLFDTAAVYGNEKALGEAIHEAIEQGLVTRNELFITSKLWVQDMNYEAAKKGIERSLEKLGLDYLDLYLLHQAMRDYFGAYRALEEAYQAGKLRAIGVSNFYPNILTNFCETVSVIPAVNQIELHPFFTQEEALETARYYGVVPEAWAPLGGGRYDAFNNAILQEVASAHQKTVGQIMLRWNVQRGVVVIPKSTHKERIEENFAIWDFSLTDDEMTKIASLDMGYGDTRTKHFDPNFVRSVLNVKIHD","643880","","oxidoreductase, aldo/keto reductase family","Cytoplasm","Several matches in gapped BLAST to oxidoreductase, aldo/keto reductase family: residues 1-288 are 67% similar to a probable reductase in E.coli (gi|15829592|). Residues 4-285 are 47% similar to the protein from Thermotoga maritima (gi|15643767|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1476 (2e-44).","

InterPro
IPR001395
Family

Aldo/keto reductase
PD000288	$\"[6-263]T$	Aldo/ket_red
PR00069	$\"[35-59]T$ $\"[95-113]T$ $\"[124-141]T$ $\"[158-187]T$ $\"[197-221]T$	ALDKETRDTASE
G3DSA:3.20.20.100	$\"[3-265]T$	Aldo/ket_red
PTHR11732	$\"[4-234]T$	Aldo/ket_red
PF00248	$\"[6-263]T$	Aldo_ket_red
PS00063	$\"[230-245]T$	ALDOKETO_REDUCTASE_3
PS00798	$\"[39-56]T$	ALDOKETO_REDUCTASE_1

noIPR
unintegrated

unintegrated
PTHR11732:SF34	$\"[4-234]T$	PTHR11732:SF34
SSF51430	$\"[1-286]T$	SSF51430

InterPro
IPR003779
Domain

Carboxymuconolactone decarboxylase
PF02627	$\"[17-102]T$	CMD

noIPR
unintegrated

unintegrated
SSF69118	$\"[10-106]T$	SSF69118

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 28-103 are 44% similar to a (DECARBOXYLASE PROTEOME COMPLETE) protein domain (PD008164) which is seen in Q9CFE3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:14:36 2002","Thu Sep 28 10:29:42 2006","Thu Sep 28 10:29:42 2006","Fri Dec 14 08:35:47 2001","","Fri Dec 14 08:35:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0622 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 08:39:06 2001","","No significant hits to the NCBI PDB database.","SMU.680","","Residues 12 to 102 (E-value = 6.6e-24) place SMu0622 in the CMD family which is described as Carboxymuconolactone decarboxylase family (PF02627)","Fri Dec 14 08:35:47 2001","24379153","","","","","","1","","","SMU.680","" "SMu0623","644674","644859","186","ATGTTAGAACAAGGGCATGATGAGCCAACTGGGCAAACAAAAATCACATCTGCTTTTAACCTTCCAGCCAAGTATATTTTGCATACGGTTGATCCTATTATTATAGGACAGGTTAGTCAGAAAGCCAAGGACTTGTTGGTTTCCTGCTATCAATCTTGTTTAGATTTGGTCATTAAAAACAGATGA","7.30","0.36","6766","MLEQGHDEPTGQTKITSAFNLPAKYILHTVDPIIIGQVSQKAKDLLVSCYQSCLDLVIKNR","644856","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypothetical protein: residues 1-59 are54% similar to the protein in S.pyogenes (gi15675180).Residues 3-56 are 52% similar to the protein in S.aureus (gi15923315).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1058 (1e-10).","

InterPro
IPR002589
Domain

Appr-1-p processing
PF01661	$\"[3-60]T$	A1pp
PS51154	$\"[1-61]T$	MACRO

noIPR
unintegrated

unintegrated
G3DSA:3.40.220.10	$\"[1-61]T$	G3DSA:3.40.220.10
PTHR11106	$\"[9-61]T$	PTHR11106
PTHR11106:SF3	$\"[9-61]T$	PTHR11106:SF3
SSF52949	$\"[1-60]T$	SSF52949

","BeTs to 3 clades of COG2110COG name: Predicted NA binding protein/domain related to histone macroH2A1Functional Class: RThe phylogenetic pattern of COG2110 is a--k-qv-e-r----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 10-61 are 50% similar to a (POLYPROTEIN NONSTRUCTURAL COMPLETE) protein domain (PD002016) which is seen in Q9UH96_HUMAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:16:33 2002","Tue Aug 29 10:32:16 2006","Tue Aug 29 10:32:16 2006","Fri Dec 14 08:40:36 2001","","Fri Dec 14 08:40:36 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0623 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 08:41:55 2001","","No significant hits to the NCBI PDB database.","SMU.681","","No significant hits to the Pfam 11.0 database","Fri Dec 14 08:40:36 2001","24379154","","","","","","1","","","SMU.681","1028" "SMu0624","645162","647720","2559","ATGGTTAAAGTCAAGATTAGCAGCAATCCGTATCAAAAGGAAATTTTGTTTGATAAATGGAATAATCAAGCAGGAGTTTGGAAGTCTATCTCTTATCAGAATAATGAAAACAGCAAACTTATATCTGATAAGATGAAGCGATCATTTTTACCTTTTACAGTAAAAGAAATTATTGACATTATTATTGAAGAATATGATGATGGCAGTGATATTGAGTTGCAGTTTGAAGGAACAGATGATGAGTTTCAAGAACTTATTTACTTGGTTAAAGAGGCTCCTTATTCGAGAATTAAAGTTTTGAAAGGGGGGAGATCCTTAGAAAATGCAAGAAAAGTGTTACCAAGGATTGCAACAATTTTTAATAAGACTTTAGAGATTATTCCTGAAAGTTTAGATGATGATTCCGATATTAAAAAATTCAAGCAATCATCGGATAGCTCCTTAATTCCATTAATCATCGTTGGAAATTATAGTTCTGGTAAATCAAGTTTTATTAATTCGCTTATTGGAAGTGATATCTTACCAAATAGTGACCGTCCAATCACAGCGAAAGTATTTGAAATTAGAAAATCTCCTCAACCTAATGTTTCACAAATCAATTTTTGGGTAAAGGATACAGCTGTTCAAATTAATATTTATGATAATGCTTATACTATTGTTCAAGGTCAAGAGTGTATTGTTGATGTTTTACCAAACATTGAGCAGCAATTCGAACAGATTAATGTACGAAATTCAGATACCATTTTGCACATGTTTTTAAAGGTTATCAATCAATATGAAGGTACAGATAATTCATTTACAATTTCTGATTTGATAACTATTAAAGTTCCTTTTAAACAAGGAATTTTAGCAGAGTCAGACAAACAATATGTTATTTTTGACACACCAGGTTCAAATTCATCATCCAATAAAAATCATTTTAAGGTTCTAAAAAAGGCTCTGCAAAATATGAGCAATGGTCTCTCTCTTTTTGTATCAGATTATACTTCTTTGGATACAGTAGATAATGAGAATTTATATGAAGAATTACGAAGTATCAAGGAAATTGATGATCGTTTTACTTTAATTATTGTTAATAAAGCTGATATGGCTGGTCTACCAAAAGAAGGGTTAGATGAAAGACAAATTCAACAAATTTTGAATCAATCTATACCAAGAAATCTTTATTCTGAGGGTATTTTCTTTGTGTCTTCTGTCATGGGACTAGGTTCAAAAAATAACGGTCAATTCATTAATGATAATTATGACCGTATCTTCAAAAAGTCTTTAAATGAATTTAATAATAGCCAGTCAGAATATTATCAAGAACTTTATCAGTATAATATCGTTCCCAAGCAGCTGGTCTCTCGGATGAAAGAGAATGTCAGAAAGGAAAGCAAACAACTTATCTATGTCAATAGCGGACTTTTTAGTATTGAAGATGAGATCGAGATGTTTGCAAACAAATACTCTGCTTATAATAAATGTCAGCAAGCAAAACTCTACCTTGAAAAGATTATTGAGAGAACGGATGCTGAAATTAGTCGTCTGAAAGCTGATTCAAGCAGAGAATTGAAATCTCTACAAGAGGAGCTTGAAAGAAATAAACAAAAGATAATTGAAGAAGTGGATCTTAAAAAACAAACTAATGACAAAAGTTTTGAAGCTGATTACACTGAGCAAATGCAGAGTAAGTCAATTGATAAGGAGAGGCTGTTCTCTTTGTCACACTTGAAAGATTTGAGTGATCGTTTATATGTTAATGCGAGAATTGATTTCAGTTTAGATAGCTATGAAGAACTCAATAACCAGACAAATGAAAAATTGAAAACTAACCTAAAAACTAATTTTGAATCTTTTAGGAAAACCATAAATTTTGCAGCGATTAAGCCTGCTTACAATCAATTACAAGATGATTTTAGAGATAAAAATAGAAACAATGAAAAATATGTAAAACAAAAGAACAAAGCTTTTGAGCAAGTTTCTCAACAATTGCTTGATCACGCAAAAACAACTTACCAGAAAGAATTAATAGAGCTCAAAAATGAATTATTCAATTTGTCTGTTGCATTCTGGGAGTTACATTCTAATAAACTAAAAGATAACCTTTCAGAAGTTATCGGGGCTGCTGAAGCTCTTTCTTTTGAAAAGCGTGAAGACATTAAGAAATTGATTTTTGACTATGAATATATAACTCTTGAGAATGATGAGTCTAAAATTTTTAATCGCAATAACTTTAAATTAGGAATTCAAATTGGTGATCTAACCTTATTTGGAAATTCGCATAAAATTGACTTAAAAAAATTAACCAATAAATACAATCAATCTTTGAATGAAGAAACAGAGATTCTAGTATCTCAAATTAAAGATTACCATCTCAACAACTATAAAGACTGGGCAGATAATCTGTTGCAAGTCATTAAGCAGAATATTGTTGACTTTAATCCTGATTTAAAGAAAACAAATGATTTAATCGTAAACAAAAATTTTCAAATTGATGATTATGAATTAAGACTGAATCAACTTAAGATCTATTCTCAAGAAATTGTAAATTTATTAGCTTGGAAGAAAAGTAACTAG","5.30","-13.29","99166","MVKVKISSNPYQKEILFDKWNNQAGVWKSISYQNNENSKLISDKMKRSFLPFTVKEIIDIIIEEYDDGSDIELQFEGTDDEFQELIYLVKEAPYSRIKVLKGGRSLENARKVLPRIATIFNKTLEIIPESLDDDSDIKKFKQSSDSSLIPLIIVGNYSSGKSSFINSLIGSDILPNSDRPITAKVFEIRKSPQPNVSQINFWVKDTAVQINIYDNAYTIVQGQECIVDVLPNIEQQFEQINVRNSDTILHMFLKVINQYEGTDNSFTISDLITIKVPFKQGILAESDKQYVIFDTPGSNSSSNKNHFKVLKKALQNMSNGLSLFVSDYTSLDTVDNENLYEELRSIKEIDDRFTLIIVNKADMAGLPKEGLDERQIQQILNQSIPRNLYSEGIFFVSSVMGLGSKNNGQFINDNYDRIFKKSLNEFNNSQSEYYQELYQYNIVPKQLVSRMKENVRKESKQLIYVNSGLFSIEDEIEMFANKYSAYNKCQQAKLYLEKIIERTDAEISRLKADSSRELKSLQEELERNKQKIIEEVDLKKQTNDKSFEADYTEQMQSKSIDKERLFSLSHLKDLSDRLYVNARIDFSLDSYEELNNQTNEKLKTNLKTNFESFRKTINFAAIKPAYNQLQDDFRDKNRNNEKYVKQKNKAFEQVSQQLLDHAKTTYQKELIELKNELFNLSVAFWELHSNKLKDNLSEVIGAAEALSFEKREDIKKLIFDYEYITLENDESKIFNRNNFKLGIQIGDLTLFGNSHKIDLKKLTNKYNQSLNEETEILVSQIKDYHLNNYKDWADNLLQVIKQNIVDFNPDLKKTNDLIVNKNFQIDDYELRLNQLKIYSQEIVNLLAWKKSN","647717","","hypothetical protein","Cytoplasm","Limited weak hits in gapped BLAST to eukaryotic hypothetical proteins, e.g. residues 211-841 are 20% similar to gi|9631364 from Melanoplus sanguinipes.SMu0624 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001401
Domain

Dynamin, GTPase region
PF00350	$\"[151-361]T$	Dynamin_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[148-429]T$	G3DSA:3.40.50.300
SSF52540	$\"[151-435]T$	SSF52540

","BeTs to 5 clades of COG0419COG name: ATPase involved in DNA repairFunctional Class: LThe phylogenetic pattern of COG0419 is amtkyqvceb------ol---Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 445-730 are 22% similar to a (COIL COILED MYOSIN CHAIN) protein domain (PD000002) which is seen in O96062_DUGJA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 09:58:34 2002","Fri Oct 11 14:16:19 2002","Fri Oct 11 14:16:19 2002","Tue Oct 8 09:58:34 2002","","Fri Mar 22 15:04:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0624 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 09:58:34 2002","","No significant hits to the NCBI PDB database.","SMU.682","","No significant hits to the Pfam 11.0 database","Fri Mar 22 15:04:34 2002","24379155","","","","","","1","","","SMU.682","" "SMu0625","647736","651149","3414","ATGGGGATTAAGAATGTTATCAGAAAAGTAGCCGGAAAAGGGGCTGATACTGTTGCAAAACTGTCGGCTCTTAGTCCAGAGCAGTTAGAACAAGTACAAGCTAAACGTGAAGAGTTTTTATCAGATTTTCCCAATATGACAGGAGCTGAGGCAGAAGAATTAACCAATCGTTTGTTAGCTGCTAATGCGGTAGAAATTTACAATGCCTATCTCCCGCAAATTGAAGATCTTTATATTCCAGTAGAGAAAGAAACTGAGTATGGTGAAGATTTTAGATCATCTAATAATATTCGCTACATTAATATCACCAAATGGGTAATTGACAAAAAAGAAAATAGTCTTGAAAAATTGGTTAATGTTTATGAAGTATTATCCAATGATGCTTGTAACATCTCTTTAGTTTTCCATCGCAAAGTTATTAAAACAGATGTTTATCTAGCCATTACTAATATTGACAATGATGATAATAATGTTGATATTGAAAGTTATCGAAGAAGACTTGAATCTGCTATTCAAGGAAATTTTCCAGGTTCTTCTTGGAAAGAAGAAATTGGACGAGGAAAGCTACCTTGCTTTAATAATAATGCACATTATTCTGTGGCAACTGCTTCTAATGTTCCAACTGAAAAATCTGAAAAATTCGTTAGTCAGACCATCGAGAAGTTGTTAGATGGTATCATTCCAGCAACAGCTCAGCAAGAATATATTTTAGTACTTTTAGCCACACCGATTCAGGATATTGCTGAAAGAAAATTGATCTTATCGCAGATTTATTCTGATTTAGCTCCTTATGCTTCTTGGCAGACTAATTATACCTATACAGAAGCTGATGCGCGTGGTTCAGCAGCAACAGTTGGCATTAATGTCGGTGCCAGTGCCGGAACACAGACTGGGACAAATTCATCTGTTACTGATACCAGTGGACAGACGGATACGGAAGGAATAACAGATACGGAGTCAAACAGTAGTACGGAAGGGGCGACTAAAACGAGCGAAACCAATAGTTCAACAACAGACACAGTTGGGGGAAGTTTCAATCAGAGTATAAAATATGGAGTTAAAGGTAGTCTAGTTTCAGGAAGTACTTCAGTTGGTGTAAATGCAAGTAGAGCAAGAACAATTGGGAAATCACTTTCTAAAGCATTTTCAAAATCAATGACAAAAGGAACTTCGTTAGCTAAAACTGCAAGTAAAGCCGTATCAAAATCAACTGCTTTAGCTACAGGTGCTTCAAAGGCTCTTAATTTTGGTATGAACTTTGGTGCTAATTTTGCTAGGACTTCCAATGTGACTGCAACTATTGGCAAAAATGAAGGGATTACCCAATCCTTTACCAATCATAATATTAAACATGCGCTGGAATTGTTAGAAGAACAGATGAAGCGCTTAGAAAAAAGTACCGCTCTTGGTATGTGGGACTTCGCGGCCTATATTCTTAGTGAAGATCAAACTGTTGCCAACAATGTAGCCTATTCTTATCTTGCTTTAACACAAGGGGAAGAATCCCATATGTCTCAGACTGTTGTTAATTTATGGCGTGGAGATGTTCAAGAAGAACAAGCTAAGGCTAATGAAATTTTTGGCTACTTAAAAGATTTGCGGCATCCTATGTTTGCACTCAATCCAGAGCTTTTAGAAAATGATGAATCTTTCAGTGTCTATCCGGCCGTTGTGACTGCAACAACCGCTTTGTCTGGAAAGGAGCTGGCTTATTCACTCAATTTTCCACAAAAATCAATTGCTGGACTCCCGGTTTTTGAGTGTGCAGAGTTTGGTCGTAATATTAATTCTTATGAAGAGACAGAAAGGGACTTTGTTAAATTAGGAAAAATTTTTCATATGAACCATACTGAGCAACTAGATGCTAAAATCAGTCTGAATTCTTTGGCTTCTCATACTTTTATCTCTGGGAGTACTGGAACAGGTAAAAGTAATACGGTATACGAGATTTTGGATGAAGTCCGCAAACATGGTGTAAAATTCCTTGTCGTTGAACCAGTAAAAGGTGAGTATAAACATATCTTTGGAAATGATGAGAACGTTTCTGTATATGGAACCAATCCAGAACTCAGCGATCTGTTGCGCATTAATCCATTTGCTTTTCCAAAAGGAATTCATGTTTTGGAACATTTGGACAGACTTATTGAAATTTTCAATGTATGTTGGCCAATGTACGCTGCTATGCCAGCAGTTCTCAAAAATGCTGTTGAAAGGGCTTATGAGGATAGTGGCTGGGATTTATTAAAATCGATAAATTCTTACGGCGATCTTTATCCGACTTTTGCAGATGTCACACGAAATATCAAGGAAATCATTGATTCCAGTGAATATGATAATGAAAATAAAGGCGCTTATAAAGGGTCGTTGCTTACACGTTTAGAGTCATTAACAAATGGGATTAACGGTATGATTTTTACCAATCAAGCTATTACTGACAAAGAATTGTTTGATGAAAATGTGATTATCGATTTAAGTCGTGTTGGTTCAACGGAAACGAAGTCACTCATTATGGGAATGCTAGTTCTAAAGTTGCAAGAATATCGCATGACTCATACAGATAGTTTGAACAATATTTTGAAACACGTAACCGTTCTTGAAGAAGCTCATAATATTTTAAAACGCACTTCCAATGAACAATCCATGGAAGACAGCAATCTTGTTGGTAAGAGTGTTGAGATGATTGCTAACGGAATTGCTGAAATGCGGACTTATGGTGAAGGATTTATCATTGCCGATCAAGCTCCCGGTTTAATGGATATGGCTGTTATTCGAAATACCAATACTAAAATTATTATGCGTTTGCCAGATTTTTCTGACAGAGAACTAGTTGGGAAATCGGCTAATCTCAATGATGATCAAATTACGGAACTAGCTAAACTTCCCAAGGGTGTTGCAGCACTTTATCAAAATGAATGGATTGAACCAATCTTGTGTAAAATCGATCAGTTCAATGGTTTAGAAAACTGTTTTGAATATCACAATCAAGTTACTAATCCAGAAAGTCATTTTTCCAGAGATATTGTGGTTGAATATCTAAGTAGCAAAAGGGTAGACGAACAGATTTTAAAGGAAATTAATTTTAAACGCTTCCTTTCTCAATTGGGAATAGACAGTTTGACTGTCCGCAGAATTTTAGACTGGGGTCGAGAACCTTTTAGCATGCATAGCTATTCTCAAATTGTGAGTCAACTTTATCCGGAATTGCTTGATTTGCTGCGAAAACAATCACTGAAAGATACAGATGTAGCAACCATGACAGATACTTTACAAAATGAAATTAATAATAGAGTATCTGATTTGCTATCAGAACAAGCAAAACGTGATCTTCTTCAGGCGACAATGACTTATTACTATCTTTATGAGCTTAAAAATAATTCTGCTTTTCAAGATTGGACGAATAATGGGGGATTTTAA","4.90","-34.55","126538","MGIKNVIRKVAGKGADTVAKLSALSPEQLEQVQAKREEFLSDFPNMTGAEAEELTNRLLAANAVEIYNAYLPQIEDLYIPVEKETEYGEDFRSSNNIRYINITKWVIDKKENSLEKLVNVYEVLSNDACNISLVFHRKVIKTDVYLAITNIDNDDNNVDIESYRRRLESAIQGNFPGSSWKEEIGRGKLPCFNNNAHYSVATASNVPTEKSEKFVSQTIEKLLDGIIPATAQQEYILVLLATPIQDIAERKLILSQIYSDLAPYASWQTNYTYTEADARGSAATVGINVGASAGTQTGTNSSVTDTSGQTDTEGITDTESNSSTEGATKTSETNSSTTDTVGGSFNQSIKYGVKGSLVSGSTSVGVNASRARTIGKSLSKAFSKSMTKGTSLAKTASKAVSKSTALATGASKALNFGMNFGANFARTSNVTATIGKNEGITQSFTNHNIKHALELLEEQMKRLEKSTALGMWDFAAYILSEDQTVANNVAYSYLALTQGEESHMSQTVVNLWRGDVQEEQAKANEIFGYLKDLRHPMFALNPELLENDESFSVYPAVVTATTALSGKELAYSLNFPQKSIAGLPVFECAEFGRNINSYEETERDFVKLGKIFHMNHTEQLDAKISLNSLASHTFISGSTGTGKSNTVYEILDEVRKHGVKFLVVEPVKGEYKHIFGNDENVSVYGTNPELSDLLRINPFAFPKGIHVLEHLDRLIEIFNVCWPMYAAMPAVLKNAVERAYEDSGWDLLKSINSYGDLYPTFADVTRNIKEIIDSSEYDNENKGAYKGSLLTRLESLTNGINGMIFTNQAITDKELFDENVIIDLSRVGSTETKSLIMGMLVLKLQEYRMTHTDSLNNILKHVTVLEEAHNILKRTSNEQSMEDSNLVGKSVEMIANGIAEMRTYGEGFIIADQAPGLMDMAVIRNTNTKIIMRLPDFSDRELVGKSANLNDDQITELAKLPKGVAALYQNEWIEPILCKIDQFNGLENCFEYHNQVTNPESHFSRDIVVEYLSSKRVDEQILKEINFKRFLSQLGIDSLTVRRILDWGREPFSMHSYSQIVSQLYPELLDLLRKQSLKDTDVATMTDTLQNEINNRVSDLLSEQAKRDLLQATMTYYYLYELKNNSAFQDWTNNGGF","651146","","conserved hypothetical protein","Extracellular, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 606-985 are 23% similar to to the protein in Sulfolobus tokodaii.Residues 606-985 are 21% similar to the protein in Sulfolobus solfataricus (gi|15899024|).SMu0625 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF52540	$\"[581-985]T$	SSF52540

","BeTs to 7 clades of COG0433COG name: Predicted ATPaseFunctional Class: RThe phylogenetic pattern of COG0433 is AMTk-Qvce-r----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 610-697 are 38% similar to a (COMPLETE PROTEOME MJ1429 APE0107) protein domain (PD006977) which is seen in YF65_METJA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 13:21:46 2002","Fri Dec 14 08:50:22 2001","Wed Jan 23 13:21:46 2002","Fri Dec 14 08:50:22 2001","","Fri Dec 14 08:50:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0625 is paralogously related (blast p-value < 1e-3) to SMu0897, a predicted wall-associated protein A precursor.","Wed Jan 23 13:20:03 2002","","No significant hits to the NCBI PDB database.","SMU.683","","No significant hits to the Pfam 11.0 database","Fri Dec 14 08:50:22 2001","24379156","","","","","","1","","","SMU.683","" "SMu0626","651153","651842","690","ATGGTATTTGAAACACTAAAACACTCAGGGAGTGAAACCAAAGTAAGCACTAGTGAAATTGGGCAAAAAAATAGTGAAATTGCATCAAATAAGGTAGATTCGGATCAGCGTATCCATCCTGTTGATGTGGTAAATGTGAAAGATAGCGATCAAGGATTAAATATAGCTGAAAGGTTTATAGCAAAAGAAAGGGGGTATTCTGAGCCTGCAATAAATTTAGCTAATAATCTGGATGAGCTAGAATCAGGAAAATACTACTCAAAAGAGATTCAGAAAGCTGCTGAACAACCACCTGAACAATTATCAGTTCTTAAAGATGAGAGATTAAAACAAAGAACTGTAAATGAAAGAGAAGTCTTACAGCACGATACAATTGATTCAAAAGAATTTTTGGATGTAAAATCACAATACAAGTTGGATGGTGAAGTAAGATATTTGACTAATCTTGAGAGGATGGAGAGGGGGTTTGCACCGATAGATGAAAGTGGGAAACCATTTAATCTGCATCATATTGGTCAAAAAATGGATTCGCCACTTGCTGAATTACCTGATCAGGTTCATAAGGATAATTATAGTAAGTTACATGCAAATAAGGGCCCTTCTAATATTGATAGAGTAGCCTTTGCTAAAGAGAAACAAGAGTATTGGAAAGCTAGAGCGGAACAAATTAAAGGAGATACTTCAGCATGA","5.70","-5.29","26038","MVFETLKHSGSETKVSTSEIGQKNSEIASNKVDSDQRIHPVDVVNVKDSDQGLNIAERFIAKERGYSEPAINLANNLDELESGKYYSKEIQKAAEQPPEQLSVLKDERLKQRTVNEREVLQHDTIDSKEFLDVKSQYKLDGEVRYLTNLERMERGFAPIDESGKPFNLHHIGQKMDSPLAELPDQVHKDNYSKLHANKGPSNIDRVAFAKEKQEYWKARAEQIKGDTSA","651839","","hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypothetical protein: residues 146-226 are 28% similar to the protein in Bacillus subtilis (gi|16078960|).Residues 12-211 are 23% similar to the protein in S.cerevisiae (gi|2131678|).SMu0626 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 146-226 are 28% similar to a (PROTEOME COMPLETE TOPI HOMOLOG) protein domain (PD140032) which is seen in O34330_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:21:15 2002","Thu Apr 25 16:54:38 2002","Tue Mar 19 14:21:15 2002","Fri Dec 14 08:52:23 2001","","Fri Dec 14 08:52:23 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0626 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 08:53:45 2001","","No significant hits to the NCBI PDB database.","SMU.684","","No significant hits to the Pfam 11.0 database","Fri Dec 14 08:52:23 2001","24379157","","","","","","1","","","SMU.684","" "SMu0627","651839","652240","402","ATGATTTTAGATATTTTAAGAGATAATGGATATAAATTAGAAGAAGATTTTTCTAAAGAAGTAGCGAAAGCTGAAACTATATTAGGTATTACATTTGCAAAAGATTATAGAGAGGCTCTAGCTAAGTTTGGAAATTTTGAAGTAAATAATCACGAGTTTACAGGTGTGCAGTTTGAAAATTATTTGAATATTGTTGTAGCTACAGTAGATAATAGAGAATATTGCCATGAGGATACGACCAAAATGTATGTGATTGAAGAATTAGGGGTTGATGGTATTGCTATTTGGCAAAATTCAAAAGGAGAAATTTTTCAAACGATTCCTAGAAAAGAGGTTAAACCTGAGAAAATTTATGATACATTCTTAGAATATTTAGAGAATGAAGTGCTTGATTCAAAATAA","4.40","-11.56","15482","MILDILRDNGYKLEEDFSKEVAKAETILGITFAKDYREALAKFGNFEVNNHEFTGVQFENYLNIVVATVDNREYCHEDTTKMYVIEELGVDGIAIWQNSKGEIFQTIPRKEVKPEKIYDTFLEYLENEVLDSK","652237","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu0627 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 14:24:38 2002","Fri Dec 14 09:20:04 2001","Wed Jan 23 14:24:38 2002","Fri Dec 14 09:20:04 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0627 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 23 14:24:38 2002","","No significant hits to the NCBI PDB database.","SMU.685","","No significant hits to the Pfam 11.0 database","Fri Dec 14 09:20:04 2001","24379158","","","","","","1","","","SMU.685","" "SMu0628","652832","652698","135","ATGCTTAATATTAGGCTAGTATCAAACTTGAAAAATCATTTCAGCGAAGTGGAAGCTGAGGTGATTCAGAATAAAAAATCAGTATTTCTGATAAAAAATAGTTATCCCTCCATGGTAGTGATGAGTTTAGAATAA","9.30","1.22","5063","MLNIRLVSNLKNHFSEVEAEVIQNKKSVFLIKNSYPSMVVMSLE","652701","","hypothetical protein","Extracellular, Periplasm","No hits in gapped BLAST found.SMu0628 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 14:25:02 2002","Fri Dec 14 09:21:40 2001","Wed Jan 23 14:25:02 2002","Fri Dec 14 09:21:40 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0628 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 23 14:25:02 2002","","No significant hits to the NCBI PDB database.","SMU.687c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 09:21:40 2001","24379159","","","","","","1","","","SMU.687c","" "SMu0629","652915","653412","498","ATGACACAAGAAATTGATATTGGGAAATACCATCAATTAGCACTGCAGAAACAGAAAGAACACCGCAAATTTCTAGCGACTCTTAAGAAAAAAGCACCTAAAAATCTGGATAAGATTGTTCAAGAAGTTCATACAGAAGTTTTTAGGGAAATTGACTGTACTAAGTGTGCTAACTGCTGTAAAATTCTGGGACCACTTTTTACGGAATCCGATATTAGTCGTATTGCTAAACATTTTCGTATGAGACTCCCAGTCTTTGAAGATATGTATTTGCGTGTGGACGAAGACAATGACAAGGTTTTTAAGTCTATGCCCTGCCCCTTTTTAGGAGAGGATAATCTCTGTTTTATCTATGATGTTCGCCCCAAGGCCTGCCGTGAATTTCCTCATACAGATCGTAAAAAAATTTATCAAATTAACCATCTGACTATCCAAAATACTCTTATTTGTCCTGCTGTCTATCTTTTTGTAGAAAAATTACAAGAAAGGCTGGCTTAA","8.40","6.06","19504","MTQEIDIGKYHQLALQKQKEHRKFLATLKKKAPKNLDKIVQEVHTEVFREIDCTKCANCCKILGPLFTESDISRIAKHFRMRLPVFEDMYLRVDEDNDKVFKSMPCPFLGEDNLCFIYDVRPKACREFPHTDRKKIYQINHLTIQNTLICPAVYLFVEKLQERLA","653409","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to hypothetical proteins: residues 2-164 are 72% similar to the protein in Lactococcus lactis subsp. lactis (gi|15674151|).Residues 5-114 are 75% similar to the protein from S.pyogenes (gi|15675056|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1430 (5e-77).","

InterPro
IPR005358
Family

Protein of unknown function UPF0153
PF03692	$\"[52-151]T$	UPF0153

","BeTs to 4 clades of COG0727COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG0727 is AM-K---c--r-UJ-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 46-133 are 73% similar to a (PROTEOME COMPLETE) protein domain (PD414146) which is seen in Q9CDQ0_LACLA.Residues 134-164 are 77% similar to a (PROTEOME COMPLETE) protein domain (PD370909) which is seen in Q9CDQ0_LACLA.Residues 2-44 are 67% similar to a (PROTEOME COMPLETE) protein domain (PD379452) which is seen in Q9CDQ0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 14:29:44 2002","Fri Dec 14 09:24:46 2001","Wed Jan 23 14:25:24 2002","Fri Dec 14 09:24:29 2001","","Fri Dec 14 09:24:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0629 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 09:24:46 2001","","No significant hits to the NCBI PDB database.","SMU.688","","Residues 51 to 155 (E-value = 4.2e-21) place SMu0629 in the UPF0153 family which is described as Uncharacterised protein family (UPF0153) (PF03692)","Fri Dec 14 09:24:29 2001","24379160","","","","","","1","","","SMU.688","948" "SMu0630","653658","656597","2940","ATGAAAAGCAAAACTTATTTGATGATTCCATTAGCATTGACCCTATTTATGGCTGCTAATAAAATATCTGCAGATGAGCAAAATCAATCCTTAAGTGCATCAGAAGTTATTTCTTCTGATGCGACATCAGTATCTGAATTACCAGCGACAACAGCACAGATAAGTCAGGAGGTCAGAAATAATGGACAAGACAGTACTATTCAATTGCAGCAAACACAGGAACAGTCTGATCCGATAACAAGTACGTCTGAGACAACTGTTTCCTCTATGAAGGCGGCCACAAATGGCTCACCTGCCAAAGCAAATGAGACTGAAACAGTTCCGTCTCAGGCAAGTACTGCTAGTTCTGTGCAGACTCCTGATCAGATTTTGACTGTTCCCTCTGTAAAAGCGGAAACCACTTCTACCGCAGATCAATTACAATCAACATCGTCTGCTCCTTTGGATCAACAAACTGATGCTAAACGTCTTTCCAATAAAATGACCCCAGCAAGCAGCGTACAAGCTCGTTCTTCTCTTACACAAGACAAGCAAGTACAGGCACAAGAAGTCACAAGTGCTGTAGTGGAAGAAAAAGGGATTAAGCTACAGTATAACGGTCAGATCGCTCGAAATACTAAGATTCAATTTGCTGTCTGGTCAGCTCGAAATGATCAAGATGATCTTCAATGGTATACGGCAAATAATATGGGAGCGGCCTATGCCGAATTCAAGAATCATCGAGAGTATGGGACCTATTATGTTCATACTTATGCTAATCAAAATGGCAAGATGATAGGACTTAACGCAACAACTCTTACAATTGCTCAACCTCAGGTGCAAACTAATATTCAAAGAAAATCAGCAACGAATTTTGAGTTAACCGTTTCTAATGTTCCTAATACTATTAGCGGCATCATGGTACCTGTCTGGTCAGATCAAAACGGTCAAGATGATATTAAATGGTATAATGCCCGAAAGGCTGATGATGGCAGTTATAAGGTTTTGATTGATACTAAAAATCACAAGAATGATTTGGGACATTATGAAGCTCATATTTACGGCTACAGCACAGTAACCCAGTCTCAAATTGGCTTAGCTGTTAGTTCTGGTTTTGACCGCAATGATACTAGACCCAATGCAAGGATATCTGTTGCTAATTATGACCAAAATAAAACGACCTTTGATGTTGTTGTTGAGGGTTCATCTGATACAAAGACTGTATCTGCTGTTAATATTGCTGTTTGGTCTGAAGATAAAGGTCAAGATGACCTTAAGTGGTATTCACCAAAAATTGTCGATAATAAGGCAACTGTGACGATTAATATCGCTAATCATTCAAATACTTCAGATAAATATAATGTCCATGTTTATACAGACTACACTGATGGGACACATTCTGGTACTATTTTAGGGGCTTATCAGATCAATAAACCGCTTGAGAAAAATACTGTTTCAGCCGATTTAACTAGTGATGGTATTGCTCTCAAATTAGATTCAAACACGGTTACAGATTATACCAAAGTACGATTTGCCGTTTGGTCGGATCAAAATGGTCAAGATGATCTCAAGTGGTATAGTGCAAATAGTGATGGAACGGCAACTGCAGCTTACAGTAACCACAGTGGTTATGGGCTTTATCATATCCATACTTATATTATTAAAGATGGGAAAATGGTTGGGCTTAATGGCAAAACGATAACTATTAATCAGCCTAGTGCCAAGGTTGATATTGCTAAAGAATCCGATGCTCTTTATAAAGTGACTGTTTCTAACCTGCCAGCTTACATTAGTTCAGTAGTTATTCCTGTCTGGACAGATAAAAACAATCAAGATGATATTCAATGGATTCCCGCGACAAAACAAGGTGATGGAACCTACGCAGCGCAAATTCAGTTAGCTGATCATAATGGGGAAACAGGCCATTATAATGTTCATGTCTATGGACAAAGTAAATTTGACAATAAAGCGGTTGGTTTAGCAGCAACTGATGGCTTTAATGTTGCAGAGACAAGGAATGCTGTTATCGCTGCTTCAAATTATAATGCCAGTGCAGGAACGATAGATATGATTGTTAAACAAGAAGCGGGTGGTAAAGCCATCAAAGAAGTTCGGATAGCTGCTTGGTCAGAAGCTGATCAATCTAACCTTCATTGGTATGTTTCATCAACTATTATTGATGGTAAGGTAACAGTCACCATTAATGAAAAAAATCATCAATATATTAAAGGAAATTATAACATTCATGTCTATGTTGATTATACTGATGGCACTAGTAGCGGAACCAATATTGGAAACTATAGCTTGAATGCTGATAAACCTGCTGTTGCTCTACCATCTTACTTTATTGATATTAGTAGCCACAATGGAATCATTTCTGTTGCCGAATTCAATAGCTTGAAACAACAAGGTATTCAAGGAGTGGTTGTTAAGTTAACAGAAGGTACAAGCTACATCAATCCATATGCAAGTTCTCAAATTGCCAATGCCAGAGCTGCCGGTATTAAGGTTTCTGCTTACCATTATGCTCACTATACTTCTGCGGCCGGGGCACAAGAAGAAGCCCGTTATTTTGCTAATGCAGCCAGATCCTTTGGTTTGGAGGCATCAACTGTCATGGTCAATGATATGGAAGAATCCTCTATGGTGAACAATATTAATAATAATGTTCAAGCTTGGCAAGATGAGATGAGGCGTCAAGGTTATAGCAACCTGATTCATTATACTATGGCTAGTTGGTTGGATATACGCGGTGGGCAAGTAGACACTGCAAGGTTTGGCATCAATAATTTTTGGGTTGCTCATTATGCCAAAGGGTATACTTATATGACTCAAGAAGAAGCTAAATCCCTTAATTATTATGCTAATGCAGCAGCTTGGCAGTATACTAGTGTATCGTCTAAATTGTCTCATGCTTTGGATGAAAATATTGATTATACTGGTCGATTTACTCAACAGTAA","5.70","-16.40","107190","MKSKTYLMIPLALTLFMAANKISADEQNQSLSASEVISSDATSVSELPATTAQISQEVRNNGQDSTIQLQQTQEQSDPITSTSETTVSSMKAATNGSPAKANETETVPSQASTASSVQTPDQILTVPSVKAETTSTADQLQSTSSAPLDQQTDAKRLSNKMTPASSVQARSSLTQDKQVQAQEVTSAVVEEKGIKLQYNGQIARNTKIQFAVWSARNDQDDLQWYTANNMGAAYAEFKNHREYGTYYVHTYANQNGKMIGLNATTLTIAQPQVQTNIQRKSATNFELTVSNVPNTISGIMVPVWSDQNGQDDIKWYNARKADDGSYKVLIDTKNHKNDLGHYEAHIYGYSTVTQSQIGLAVSSGFDRNDTRPNARISVANYDQNKTTFDVVVEGSSDTKTVSAVNIAVWSEDKGQDDLKWYSPKIVDNKATVTINIANHSNTSDKYNVHVYTDYTDGTHSGTILGAYQINKPLEKNTVSADLTSDGIALKLDSNTVTDYTKVRFAVWSDQNGQDDLKWYSANSDGTATAAYSNHSGYGLYHIHTYIIKDGKMVGLNGKTITINQPSAKVDIAKESDALYKVTVSNLPAYISSVVIPVWTDKNNQDDIQWIPATKQGDGTYAAQIQLADHNGETGHYNVHVYGQSKFDNKAVGLAATDGFNVAETRNAVIAASNYNASAGTIDMIVKQEAGGKAIKEVRIAAWSEADQSNLHWYVSSTIIDGKVTVTINEKNHQYIKGNYNIHVYVDYTDGTSSGTNIGNYSLNADKPAVALPSYFIDISSHNGIISVAEFNSLKQQGIQGVVVKLTEGTSYINPYASSQIANARAAGIKVSAYHYAHYTSAAGAQEEARYFANAARSFGLEASTVMVNDMEESSMVNNINNNVQAWQDEMRRQGYSNLIHYTMASWLDIRGGQVDTARFGINNFWVAHYAKGYTYMTQEEAKSLNYYANAAAWQYTSVSSKLSHALDENIDYTGRFTQQ","656594","Two bands, 107 Kda and 79 Kda, are reported by Shibata et al., 2005.","autolysin/endolysin","Extracellular","Matches in gapped BLAST to hypothetical protein:residues 276-353 are 47%,residues 569-641 are 40%,residues 376-542 are 26% and residues 675-750 are 31% similar to the previously published enzyme in S.mutans (gi280251).Residues 23-228 are 20% similar to gi14248429 as seen in S.aureusThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1350 (4e-16).","

InterPro
IPR002053
Family

Glycoside hydrolase, family 25
PD004620	$\"[777-957]T$	Glyco_hydro_25
PF01183	$\"[776-964]T$	Glyco_hydro_25

InterPro
IPR008270
Active_site

Glycoside hydrolase, family 25, active site
PS00953	$\"[777-813]?$	GLYCOSYL_HYDROL_F25

InterPro
IPR013688
Repeat

GBS Bsp-like
PF08481	$\"[194-268]T$ $\"[273-367]T$ $\"[376-469]T$ $\"[475-562]T$ $\"[567-661]T$ $\"[669-762]T$	GBS_Bsp-like

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[769-973]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
SSF51445	$\"[769-975]T$	SSF51445

","No hits to the COGs database.","***** IPB002053 (Glycosyl hydrolases family 25) with a combined E-value of 7.2e-10. IPB002053A 797-817 IPB002053B 830-839 IPB002053C 917-932","Residues 776-930 are 27% similar to a (HYDROLASE LYSOZYME GLYCOSIDASE LYSIN) protein domain (PD004620) which is seen in Q9RJP9_STRCO.Residues 22-166 are 25% similar to a (POLY3-HYDROXYBUTYRATE FAECALIS SIMILAR) protein domain (PD241170) which is seen in Q22579_CAEEL.Residues 23-189 are 26% similar to a (C215.13 SERINE-RICH PRECURSOR CHROMOSOME) protein domain (PD194653) which is seen in O94317_SCHPO.Residues 12-186 are 28% similar to a (STREPTOCOCCAL HEMAGGLUTININ) protein domain (PD327862) which is seen in Q9KWR3_STRGN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 5 10:41:29 2005","Thu Feb 22 12:37:45 2007","Tue Jul 5 10:41:29 2005","Fri Dec 14 09:25:49 2001","Fri Dec 14 09:25:49 2001","Fri Dec 14 09:25:49 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0630 is paralogously related (blast p-value < 1e-3) to SMu0760 and SMu0018,both predicted glucan-binding protein B;immunodominant glycoprotein IDG-60; general stress protein GSP-781, SMu0555,a predicted 40K cell wall protein precursor (sr 5' region);choline binding protein D, SMu1273,a predicted glucan-binding protein C, SMu0999, a predicted sr protein, SMu1947 and SMu0057, both predicted conserved hypothetical proteins,and SMu0676, a predicted cell division protein FtsY; signal recognition particle (dockingprotein).","Wed Jun 4 20:57:59 2008","","No significant hits to the NCBI PDB database.","SMU.689","","Residues 774 to 886 (E-value = 6.8e-18) place SMu0630 in the Glyco_hydro_25 family which is described as Glycosyl hydrolases family 25 (PF01183)","Fri Dec 14 09:25:49 2001","24379161",""," Yoshimura G, Komatsuzawa H, Hayashi I, Fujiwara T, Yamada S, Nakano Y, Tomita Y, Kozai K, Sugai M.Identification and molecular characterization of an N-Acetylmuraminidase, Aml, involved in Streptococcus mutans cell separation.Microbiol Immunol. 2006;50(9):729-42.PMID: 16985295Shibata Y, Kawada M, Nakano Y, Toyoshima K, Yamashita Y.Identification and characterization of an autolysin-encoding gene of Streptococcus mutans.Infect Immun. 2005 Jun;73(6):3512-20.PMID: 15908380Brown TA, Ahn SJ, Frank RN, Chen YY, Lemos JA, Burne RA.A hypothetical protein of Streptococcus mutans is critical for biofilm formation.Infect Immun. 2005 May;73(5):3147-51.PMID: 15845523","","Wed Jun 4 20:57:59 2008","","1","","","SMU.689","" "SMu0631","656618","657205","588","ATGAAAAGAAAACGAAATCTTTACTTTCTTATTGGTTTATTTTTGACAGTCTTTCTTTTGATAGGATGCTCAATGCAGAAAAAAACCAAATCAGAAAGCAGCTCGACTTCTCAAAAGACTACTTTACAAACAAAACAGTCAAGTGAAAAATCAACTGATGCTAAGCAAACGACAGAAGCTCATTCAGAAAGCAGTCAGTCTTCTTCTCATTCTAATAACGAGGAAACCCTTGCTCCCATTGATACAGGCGCTGTTTTAAAGGCTGATTACAGTAGTATGGCAGGAACTTGGAAAAATGAAGAAGGACAAACGTTGACATTTGATCAGCGAGGTCTGACAACCCCTGGAATGACAGTCAGTCTGTTGAACATTGATCAAGACGGAAATCTTTTGTTAAATGTTGAGACTGGAACAAAAAAGAATCTAACTCTTTATATTGTGCCAGCCAATAAAACCTTATCTAATCAATATTTTTCTAATGGTCAAAGCGATGAATCCGATAAAACAAAAGATCGTATTGTTTCTTCTGAGAGTTTAAATAGTGGCAAATTTACAAACCGAGTTTATTATCATGTTTCAACTCATTAA","9.10","2.91","21553","MKRKRNLYFLIGLFLTVFLLIGCSMQKKTKSESSSTSQKTTLQTKQSSEKSTDAKQTTEAHSESSQSSSHSNNEETLAPIDTGAVLKADYSSMAGTWKNEEGQTLTFDQRGLTTPGMTVSLLNIDQDGNLLLNVETGTKKNLTLYIVPANKTLSNQYFSNGQSDESDKTKDRIVSSESLNSGKFTNRVYYHVSTH","657202","","hypothetical protein","Extracellular","No significant hits in gapped BLAST found.SMu0631 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PS51257	$\"[1-23]T$	PROKAR_LIPOPROTEIN

InterPro
IPR001261
Family

ArgE/dapE/ACY1/CPG2/yscS
PS00758	$\"[75-84]T$	ARGE_DAPE_CPG2_1
PS00759	$\"[139-178]T$	ARGE_DAPE_CPG2_2

InterPro
IPR002933
Family

Peptidase M20
PF01546	$\"[141-402]T$	Peptidase_M20

InterPro
IPR010161
Family

Peptidase M20B, tripeptide aminopeptidase
TIGR01882	$\"[2-403]T$	peptidase-T: peptidase T

InterPro
IPR011650
Domain

Peptidase M20, dimerisation
PF07687	$\"[207-311]T$	M20_dimer

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.10	$\"[3-402]T$	no description
PTHR11014	$\"[1-92]T$ $\"[118-402]T$	PEPTIDASE M20 FAMILY MEMBER
PTHR11014:SF3	$\"[1-92]T$ $\"[118-402]T$	PEPTIDASE T

","No hits to the COGs database.","***** IPB001261 (ArgE/dapE/ACY1/CPG2/yscS family) with a combined E-value of 3.3e-12. IPB001261A 140-152 IPB001261B 167-176 IPB001261C 366-382","Residues 4-323 are 58% similar to a (TRIPEPTIDASE 3.4.11.- AMINOTRIPEPTIDASE) protein domain (PD014167) which is seen in PEPT_LACLC.Residues 334-395 are 83% similar to a (PEPTIDASE TRIPEPTIDASE METALLOPROTEASE) protein domain (PD246414) which is seen in PEPT_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 13:10:02 2006","Fri Oct 11 14:25:51 2002","Thu Sep 14 13:10:02 2006","Fri Dec 14 09:42:25 2001","Fri Dec 14 09:42:25 2001","Fri Dec 14 09:42:25 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0632 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 09:45:28 2001","","No significant hits to the NCBI PDB database.","SMU.691","","Residues 7 to 405 (E-value = 6.3e-50) place SMu0632 in the Peptidase_M20 family which is described as Peptidase family M20/M25/M40 (PF01546)","Fri Dec 14 09:42:25 2001","24379163","","","Mierau,I.,Haandrikman,A.J.,Velterop,O.,Tan,P.S.,Leenhouts,K.L.,Konings,W.N., Venema,G. and Kok,J.Tripeptidase gene (pepT) of Lactococcus lactis: molecular cloningand nucleotide sequencing of pepT and construction of a chromosomal deletion mutantJ. Bacteriol. 176 (10), 2854-2861 (1994)PubMed: 8188586Schrogel,O., Krispin,O. and Allmansberger,R.Expression of a pepT homologue from Bacillus subtilisFEMS Microbiol. Lett. 145 (3), 341-348 (1996)PubMed: 8978088Miller,C.G., Miller,J.L. and Bagga,D.A.Cloning and nucleotide sequence of the anaerobically regulated pepT gene of Salmonella typhimuriumJ. Bacteriol. 173 (11), 3554-3558 (1991)PubMed: 1904438Strauch,K.L. and Miller,C.G.Isolation and characterization Salmonella typhimurium mutantslacking a tripeptidase (peptidase T)J. Bacteriol. 154 (2), 763-771 (1983)PubMed: 6341363","","Fri Dec 14 09:52:57 2001","1","","","SMU.691","416" "SMu0633","658574","659059","486","GTGATTAAGATATTTGGGAAAGTTAGATATCATTGGCAGCCTGAACTGTCATGGCTGATTATTTACTGGTCTATCACTATTATGCCAATTTTTATTGCCTTGTCACTTTTGTATGAACAAACTTCTATTCCGCAATATTTCTTTATTTTATTCATTACATTTGTTGTTTTAGTTGGTGTTGGTTTTCATCGCTACTTTGTGATTGAAAATAATGGCATTTTACGAGTTGTTTCTTTAAATGTTTTCAAGCCTTCAAAAATTGCTATTGCAGATATAAAAAAAGTAGAGGTAACAAAGTCAACTGTGACTCTGATTGTAAAAGGTAAGAAAAAGTGTCTCTTTTATATGCGTAAGTGGCCTAAAAAATATTTTTTAGATGCTTTGGCACTTCATCCAGATTTCAAGGGAGAAGTGGAGCTCATTGATAATTTTATCAATCTTGATTATTTTGAAGCTTATAAAAAAGAAAAAAAGCCCTTACGGTAA","10.50","11.66","19058","MIKIFGKVRYHWQPELSWLIIYWSITIMPIFIALSLLYEQTSIPQYFFILFITFVVLVGVGFHRYFVIENNGILRVVSLNVFKPSKIAIADIKKVEVTKSTVTLIVKGKKKCLFYMRKWPKKYFLDALALHPDFKGEVELIDNFINLDYFEAYKKEKKPLR","659056","","possible pore-forming peptide","Membrane, Cytoplasm","Matches in gapped BLAST to pore-forming peptide:residues 1-160 are61% similar to the protein in S.pyogenes (gi15674842).Residues 7-135 are 25% similar to the protein in Enterococcus faecalis(gi544224). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1388 (1e-53).","

InterPro
IPR000276
Family

Rhodopsin-like GPCR superfamily
PS00237	$\"[52-68]?$	G_PROTEIN_RECEP_F1_1

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[19-37]?$ $\"[47-67]?$	transmembrane_regions

InterPro
IPR001450
Domain

4Fe-4S ferredoxin, iron-sulfur binding
PR00353	$\"[3-14]T$ $\"[51-62]T$	4FE4SFRDOXIN

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.20	$\"[1-61]T$	G3DSA:3.30.70.20
SSF54862	$\"[1-63]T$	SSF54862

","BeTs to 3 clades of COG1141COG name: Ferredoxin 1Functional Class: CThe phylogenetic pattern of COG1141 is a-t---v--bR----------Number of proteins in this genome belonging to this COG is 1","***** PR00353 (4Fe-4S ferredoxin signature) with a combined E-value of 4.1e-06. PR00353A 3-14 PR00353B 51-62","Residues 6-61 are 56% similar to a (I IRON-SULFUR PHOTOSYSTEM FERREDOXIN) protein domain (PD009020) which is seen in Q9CEX9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 14:45:40 2002","Fri Dec 14 09:59:43 2001","Fri Oct 11 14:32:24 2002","Fri Dec 14 09:59:43 2001","Fri Dec 14 09:59:43 2001","Fri Dec 14 09:59:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0634 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:01:26 2001","","No significant hits to the NCBI PDB database.","SMU.694c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 09:59:43 2001","24379165","","","Elliott,J.I., Yang,S.S., Ljungdahl,L.G., Travis,J. and Reilly,C.F.Complete amino acid sequence of the 4Fe-4S, thermostable ferredoxin from Clostridium thermoaceticumBiochemistry 21 (14), 3294-3298 (1982)PubMed: 7115670Hase,T., Ohmiya,N., Matsubara,H., Mullinger,R.N., Rao,K.K. andHall,D.O.Amino acid sequence of a four-iron-four-sulphur ferredoxin isolated from Bacillus stearothermophilusBiochem. J. 159 (1), 55-63 (1976)PubMed: 999643Fukuyama,K., Nagahara,Y., Tsukihara,T., Katsube,Y., Hase,T. andMatsubara,H.Tertiary structure of Bacillus thermoproteolyticus [4Fe-4S]ferredoxin. Evolutionary implications for bacterial ferredoxinsJournal of molecular biology. 199 (1), 183-193 (1988)PubMed: 3351918Fukuyama,K., Matsubara,H., Tsukihara,T. and Katsube,Y.Structure of [4Fe-4S] ferredoxin from Bacillus thermoproteolyticusrefined at 2.3 A resolution. Structural comparisons of bacterialferredoxinsJournal of molecular biology. 210 (2), 383-398 (1989)PubMed: 2600971","","Fri Dec 14 10:07:34 2001","1","","","SMU.694c","1019" "SMu0635","659291","659773","483","ATGTCAAATAAACCATGGGAAGAAAAAGTAACTGATGCAACTACTGATAATGAAGAAATGACAAGAAATTCAAAGGATGCTAGTATTATCAGTACACCTATTTTAACAATCCTATTGAGCCTCTTTTTCTTGATTATTATTGGTATTTTATTTTTTGTACTTTATACTTCAAATGGTGGAAGCAATGAAAAAGCAGCCACTTCGGGTTTCTATAGTTCTTCCAAAACGGTCAAAAAAGCCAAAAATGAGGCAAATAGTCAAACTGATGAACAGACAACAGAAGCAGAAACAAGTTCAAGTGAAACGACAAGTTCCTCTTCAGACAGTGATGGCGAGACAATTACAGTTCAAGGAGGTGAAGGGGCTGCAGCAATTGCTGCGCGTGCGGGTATTTCTGTTGATAAACTCTATGAGCTGAATCCAGAACATATGACGCATGGCTATTGGTATGCTAACCCTGGAGATAACATCAAGATTAAGTAA","4.50","-8.52","17215","MSNKPWEEKVTDATTDNEEMTRNSKDASIISTPILTILLSLFFLIIIGILFFVLYTSNGGSNEKAATSGFYSSSKTVKKAKNEANSQTDEQTTEAETSSSETTSSSSDSDGETITVQGGEGAAAIAARAGISVDKLYELNPEHMTHGYWYANPGDNIKIK","659770","","conserved hypothetical protein","Extracellular, Membrane","Limited matches in gapped BLAST to hypothetical proteins: residues 1-160 are 33% similar to the protein in S.pyogenes (gi|15674844|) are 26% similar to the protein from S.pneumoniae (gi|15901444).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1386 (2e-15).","

InterPro
IPR002482
Domain

Peptidoglycan-binding LysM
PF01476	$\"[114-160]T$	LysM

noIPR
unintegrated

unintegrated
SSF54106	$\"[110-159]T$	SSF54106

InterPro
IPR003136
Family

Cytidylate kinase
PTHR21299:SF2	$\"[16-216]T$	Cytidylate_kin
TIGR00017	$\"[2-220]T$	cmk

InterPro
IPR011769
Domain

Adenylate/cytidine kinase, N-terminal
PD000657	$\"[6-48]T$	Adenylate_kin

InterPro
IPR011994
Domain

Cytidylate kinase region
PF02224	$\"[59-218]T$	Cytidylate_kin

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-227]T$	G3DSA:3.40.50.300
PTHR21299	$\"[16-216]T$	PTHR21299
SSF52540	$\"[1-226]T$	SSF52540

","BeTs to 11 clades of COG0283COG name: Cytidylate kinaseFunctional Class: FThe phylogenetic pattern of COG0283 is -----qvcebrH--gpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003136 (Cytidylate kinase) with a combined E-value of 3.6e-84. IPB003136A 6-39 IPB003136B 86-120 IPB003136C 129-166 IPB003136D 174-205***** IPB000623 (Shikimate kinase) with a combined E-value of 3.1e-06. IPB000623A 6-35","Residues 43-216 are 52% similar to a (KINASE CYTIDYLATE ATP-BINDING CYTIDINE) protein domain (PD005731) which is seen in KCY_BACSU.Residues 6-64 are 38% similar to a (KINASE CYTIDINE TRANSFERASE CMP) protein domain (PD207522) which is seen in KCY_RICPR.Residues 6-39 are 85% similar to a (KINASE CYTIDYLATE ATP-BINDING CYTIDINE) protein domain (PD034497) which is seen in KCY_LACLA.Residues 4-39 are 66% similar to a (KINASE CYTIDINE TRANSFERASE CMP) protein domain (PD175890) which is seen in KCY_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:34:23 2002","Fri Dec 14 10:18:16 2001","Fri Oct 11 14:34:23 2002","Fri Dec 14 10:11:10 2001","Fri Dec 14 10:11:10 2001","Fri Dec 14 10:11:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0636 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:12:26 2001","Fri Dec 14 10:11:10 2001","pdb|2CMK|A Chain A, Cytidine Monophosphate Kinase In Complex Wi... 158 5e-040pdb|1CKE|A Chain A, Cmp Kinase From Escherichia Coli Free Enzym... 155 3e-039","SMU.696","","Residues 59 to 218 (E-value = 3.8e-62) place SMu0636 in the Cytidylate_kin family which is described as Cytidylate kinase (PF02224)","Fri Dec 14 10:11:10 2001","24379167","","","","","","1","","","SMU.696","583" "SMu0637","660634","661164","531","GTGAAGAATATCGCTAAAAAAGATTTGTTCATTAACAATGAAATTCGTGTCCGCGAAGTTCGCCTTATTGGTCTTGATGGTGAGCAATTGGGAATTAAACCATTAGCCCAAGCACAGGCTATTGCAGATGATGCTAATGTCGACTTGGTTTTAATTCAGCCGCAGGCTACACCGCCTGTTGCTCGTATTATGGACTATGGTAAGTTCAAATTTGAGTATCAAAAGAAACAAAAAGAACAACGTAAGAAACAAAGCGTTGTTACCATTAAAGAAGTCCGTTTAAGTCCAGTTATTGATAAAGGTGACTTTGAGACAAAGCTTCGTAATGGGCGTAAGTTCCTTGAAAAGGGAAATAAGGTTAAAGTTTCTATTCGTTTTAAGGGACGTATGATTACTCACAAGGAAATTGGAGCAAAAGTTTTAGCTGATTTTGCTGAGGCAACGCAAGATATTGCTATTATTGAGCAAAGGGCTAAGATGGATGGCCGTCAAATGTTCATGCAGCTTGCACCAATTCCAGATAAAAAATAA","10.70","13.24","20055","MKNIAKKDLFINNEIRVREVRLIGLDGEQLGIKPLAQAQAIADDANVDLVLIQPQATPPVARIMDYGKFKFEYQKKQKEQRKKQSVVTIKEVRLSPVIDKGDFETKLRNGRKFLEKGNKVKVSIRFKGRMITHKEIGAKVLADFAEATQDIAIIEQRAKMDGRQMFMQLAPIPDKK","661161","IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits,thus enhancing the subunits on which protein synthesis initiation begins [gi:14194827]. ","translation initiation factor IF-3","Cytoplasm, Periplasm","Several matches in gapped BLAST to translation initiation factor 3: residues 1-176 are 81% similar to the protein in S.pyogenes (gi15674846)and are 80% similar to the protein from S.pneumoniae (gi15902905).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1384 (5e-80).","

InterPro
IPR001288
Family

Initiation factor 3
PD002880	$\"[94-175]T$	IF3_STRMU_Q8DV22;
G3DSA:3.10.20.80	$\"[5-82]T$	no description
G3DSA:3.30.110.10	$\"[83-176]T$	no description
PTHR10938	$\"[26-171]T$	TRANSLATION INITIATION FACTOR IF-3
PF00707	$\"[86-173]T$	IF3_C
PF05198	$\"[6-81]T$	IF3_N
TIGR00168	$\"[11-174]T$	infC: translation initiation factor IF-3
PS00938	$\"[62-75]T$	IF3

","BeTs to 12 clades of COG0290COG name: Translation initiation factor IF3Functional Class: JThe phylogenetic pattern of COG0290 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001288 (Initiation factor 3) with a combined E-value of 2.1e-82. IPB001288A 11-33 IPB001288B 42-90 IPB001288C 93-144 IPB001288D 159-172","Residues 11-171 are 81% similar to a (FACTOR INITIATION TRANSLATION IF-3) protein domain (PD002880) which is seen in IF3_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 15:26:40 2002","Wed Aug 30 17:03:15 2006","Wed Aug 30 17:01:45 2006","Fri Dec 14 10:22:51 2001","Fri Dec 14 10:22:51 2001","Fri Dec 14 10:22:51 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0637 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:24:23 2001","Wed Aug 30 17:01:45 2006","pdb1TIG Translation Initiation Factor 3 C-Terminal Domain 120 9e-029pdb2IFEA Chain A, Translation Initiation Factor If3 From Esch... 83 3e-017pdb1TIF Translation Initiation Factor 3 N-Terminal Domain 74 1e-014","SMU.697","","Residues 6 to 81 (E-value = 1.6e-47) place SMu0637 in the IF3_N family which is described as Translation initiation factor IF-3, N-terminal domain (PF05198)Residues 86 to 173 (E-value = 1.3e-44) place SMu0637 in the IF3_C family which is described as Translation initiation factor IF-3, C-terminal domain (PF00707)","Wed Aug 30 17:01:45 2006","24379168","","","Engelbrecht,F., Dickneite,C., Lampidis,R., Gotz,M., DasGupta,U. and Goebel,W.Sequence comparison of the chromosomal regions encompassing theinternalin C genes (inlC) of Listeria monocytogenes and L. ivanoviiMol. Gen. Genet. 257 (2), 186-197 (1998)PubMed: 9491077Pon,C.L., Brombach,M., Thamm,S. and Gualerzi,C.O.Cloning and characterization of a gene cluster from Bacillusstearothermophilus comprising infC, rpmI and rplTMol. Gen. Genet. 218 (2), 355-357 (1989)PubMed: 2779520Kimura,M., Ernst,H. and Appelt,K.The primary structure of initiation factor IF3 from BacillusstearothermophilusFEBS Lett. 160 (1-2), 78-81 (1983)PubMed: 6884517Spurio,R., Paci,M., Pawlik,R.T., La Teana,A., DiGiacco,B.V.,Pon,C.L. and Gualerzi,C.O.Site-directed mutagenesis and NMR spectroscopic approaches to theelucidation of the structure-function relationships in translationinitiation factors IF1 and IF3Biochimie 73 (7-8), 1001-1006 (1991)PubMed: 1742345Hua,Y. and Raleigh,D.P.On the global architecture of initiation factor IF3: a comparativestudy of the linker regions from the Escherichia coli protein andthe Bacillus stearothermophilus proteinJ. Mol. Biol. 278 (4), 871-878 (1998)PubMed: 9614948Biou,V., Shu,F. and Ramakrishnan,V.X-ray crystallography shows that translational initiation factorIF3 consists of two compact alpha/beta domains linked by analpha-helixEMBO J. 14 (16), 4056-4064 (1995)PubMed: 7664745","","Fri Dec 14 10:30:18 2001","1","","","SMU.697","582" "SMu0638","661199","661399","201","ATGCCAAAACAAAAAACACACCGCGCATCAGCTAAACGTTTTAAACGTACAGGTTCAGGTGGATTGAAACGCTTCCGTGCATATACCTCTCACCGCTTCCACGGTAAGACCAAGAAACAACGTCGTCATCTTCGTAAAGCATCAATGGTGCATTCAGGAGATTTCAAACGTATTAAGTCAATGCTTACTCGCTTAAAATAA","12.90","23.17","7819","MPKQKTHRASAKRFKRTGSGGLKRFRAYTSHRFHGKTKKQRRHLRKASMVHSGDFKRIKSMLTRLK","661396","For other 'rpm' genes see SMu0108 (rpmB);SMu0773 (rpmA);SMu0306 (rpmH); SMu1185 (rpmE) and SMu1464 (rpmG). ","50S ribosomal protein L35","Periplasm, Extracellular","Several matches in gapped BLAST to 50S ribosomal protein L35: residues 1-66 are 96% similar to the protein in S.pneumoniae (gi|15900837|).Residues 1-65 are 89% similar to the protein from S.pyogenes (gi|15674847|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1383 (1e-32).","

InterPro
IPR001706
Family

Ribosomal protein L35
PD003417	$\"[5-62]T$	Ribosomal_L35
PR00064	$\"[3-20]T$ $\"[21-35]T$ $\"[36-54]T$	RIBOSOMALL35
PF01632	$\"[5-62]T$	Ribosomal_L35p
TIGR00001	$\"[2-64]T$	rpmI_bact
PS00936	$\"[5-31]T$	RIBOSOMAL_L35

","BeTs to 13 clades of COG0291COG name: Ribosomal protein L35Functional Class: JThe phylogenetic pattern of COG0291 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001706 (Ribosomal protein L35) with a combined E-value of 7.7e-23. IPB001706 2-40 IPB001706 13-51","Residues 5-61 are 85% similar to a (RIBOSOMAL 50S CHLOROPLAST PROTEOME) protein domain (PD003417) which is seen in Q9CEJ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:36:51 2002","Fri Dec 14 10:33:13 2001","Fri Oct 11 14:36:51 2002","Fri Dec 14 10:33:13 2001","Fri Dec 14 10:33:13 2001","Fri Dec 14 10:33:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0638 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:33:42 2001","","No significant hits to the NCBI PDB database.","SMU.698","","Residues 5 to 62 (E-value = 6.7e-22) place SMu0638 in the Ribosomal_L35p family which is described as Ribosomal protein L35 (PF01632)","Fri Dec 14 10:33:13 2001","24379169","","","Pon,C.L., Brombach,M., Thamm,S. and Gualerzi,C.O.Cloning and characterization of a gene cluster from Bacillusstearothermophilus comprising infC, rpmI and rplTMol. Gen. Genet. 218 (2), 355-357 (1989)PubMed: 2779520Hu,W.S., Wang,R.Y., Shih,J.W. and Lo,S.C.Identification of a putative infC-rpmI-rplT operon flanked by longinverted repeats in Mycoplasma fermentans (incognitus strain)Gene 127 (1), 79-85 (1993)PubMed: 8486291","","Fri Dec 14 10:37:53 2001","1","","","SMU.698","944" "SMu0639","661444","661803","360","ATGGCTCGTGTTAAAGGTGGCGTTGTTTCACGTAAACGTCGTAAACGTGTTTTAAAATTAGCTAAAGGATACTATGGCGCAAAACATATCTTGTTCCGTACTGCAAAAGAACAAGTGATGAATTCATACTATTATGCTTATCGTGACCGTCGTCAAAGAAAGCGTGATTTCCGTAAATTATGGATTACACGTATCAATGCAGCAGCACGTATGAATGGATTGTCATATTCACAATTAATGCATGGTTTGAAGTTGGCTGAAGTCGAAGTGAATCGCAAAATGCTTGCAGATTTAGCGGTTAACGATGCAGCAGCTTTCACAGTTCTTGCAGATGCAGCTAAAGAAAAACTTGGGAAATAA","11.50","20.46","13735","MARVKGGVVSRKRRKRVLKLAKGYYGAKHILFRTAKEQVMNSYYYAYRDRRQRKRDFRKLWITRINAAARMNGLSYSQLMHGLKLAEVEVNRKMLADLAVNDAAAFTVLADAAKEKLGK","661800","For other 'rpl' genes see SMu0771 (rplU); SMu0152 (rplM); SMu1941 (rplI);SMu0869 (rplJ); SMu0872 (rpl); SMu1175 (rplS); SMu1480 (rplA) and SMu1481 (rplK).From Genbank: [gi:14195116]This protein binds directly to 23S ribosomal RNA and is necessary to the in vitro assembly process of the 50S ribosomal subunit;it is not involved in the protein synthesizing functions of that subunit.","50S ribosomal protein L20","Periplasm, Cytoplasm","Several matches in gapped BLAST to ribosomal protein L20: residues 23-119 are 69% similar to the protein in S.pneumoniae (gi|15900838|)and are 68% similar to the protein from S.pyogenes (gi|15674848|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1382 (4e-32).","

InterPro
IPR005812
Family

Ribosomal protein L20, bacterial and organelle form
PR00062	$\"[12-41]T$ $\"[42-71]T$ $\"[75-101]T$	RIBOSOMALL20
TIGR01032	$\"[1-114]T$	rplT_bact
PS00937	$\"[54-70]T$	RIBOSOMAL_L20

InterPro
IPR005813
Family

Ribosomal protein L20
PD002389	$\"[23-69]T$	Ribosomal_L20
PTHR10986	$\"[1-115]T$	Ribosomal_L20
PF00453	$\"[2-109]T$	Ribosomal_L20

noIPR
unintegrated

unintegrated
G3DSA:1.10.1900.20	$\"[61-118]T$	G3DSA:1.10.1900.20
SSF74731	$\"[61-118]T$	SSF74731

","BeTs to 12 clades of COG0292COG name: Ribosomal protein L20Functional Class: JThe phylogenetic pattern of COG0292 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001081 (Ribosomal protein L20) with a combined E-value of 6.4e-39. IPB001081 32-77","Residues 23-102 are 67% similar to a (RIBOSOMAL 50S RRNA-BINDING CHLOROPLAST) protein domain (PD002389) which is seen in RL20_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:37:30 2002","Fri Dec 14 14:43:27 2001","Fri Oct 11 14:37:30 2002","Fri Dec 14 10:40:10 2001","Fri Dec 14 10:40:10 2001","Fri Dec 14 10:40:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0639 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 10:40:20 2001","","No significant hits to the NCBI PDB database.","SMU.699","","Residues 2 to 109 (E-value = 2e-65) place SMu0639 in the Ribosomal_L20 family which is described as Ribosomal protein L20 (PF00453)","Fri Dec 14 10:40:10 2001","24379170","","","Pon,C.L., Brombach,M., Thamm,S. and Gualerzi,C.O.Cloning and characterization of a gene cluster from Bacillusstearothermophilus comprising infC, rpmI and rplTMol. Gen. Genet. 218 (2), 355-357 (1989)PubMed: 2779520","","Fri Dec 14 10:45:10 2001","1","","","SMU.699","698" "SMu0640","662636","662010","627","ATGAAATTGTATTTTGTAAGACATGGTAAAACGGAATGGAACCTAGAAGGACGTTTCCAAGGAGCTCATGGAGATTCACCTCTCTTAAGTACATCAATTATAGAACTAAGAGCATTAGGACACTATCTCAAAGATATTACATTTGATCACATTTATTCTAGTGACCTGAAAAGAGCTAAATTAACTAGTCAAATTATCAATCAAGAAAACAAACATTCTGTAAAAATTGAATACACCAAGGCCTTACGAGAATGGAATTTAGGCAGTCTGGAAGGTCAAAAAATCAGCCTTGTTACTTCTATCTATCCCAAACAAATGAAAGCTTTCCGTCATAATCTAGCACAATTTAACAATTCAATGTTTGATGCTGAATCCGTCTATCGTGTAACACATCGTGTTTCTAATTTTGTTAAATCACTACAAAAGGAAACGGCTCAAAATATCTTAATAGTCGGACATGGTGCAACTTTGACCGCCTCTATTCAAACATTATTAGGCTGTGAACCTGCTCAACTACGACGTGACGGCGGTCTTGATAATGCTAGTGTGACCATTTTAGAAACAAAAGATTTCGAACGTTTTAAACTCCTTAAGTGGAATGATACCTCTTATAAAAAAGAATTGTAA","10.20","8.87","23815","MKLYFVRHGKTEWNLEGRFQGAHGDSPLLSTSIIELRALGHYLKDITFDHIYSSDLKRAKLTSQIINQENKHSVKIEYTKALREWNLGSLEGQKISLVTSIYPKQMKAFRHNLAQFNNSMFDAESVYRVTHRVSNFVKSLQKETAQNILIVGHGATLTASIQTLLGCEPAQLRRDGGLDNASVTILETKDFERFKLLKWNDTSYKKEL","662013","For other 'gpm' genes see SMu0067 (gpm); SMu0543 (gpmA); SMu1008 (gpm); SMu1009 (gpm) and SMu1010 (gpm).","phosphoglycerate mutase","Cytoplasm, Membrane","Several matches in gapped BLAST to phosphoglycerate mutase: residues 1-205 are 60% similar to the enzyme in S.pneumoniae (gi|15902931|).Residues 1-204 are 56% similar to the protein from S.pyogenes (gi|15674681|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0752 (4e-63).","

InterPro
IPR013078
Domain

Phosphoglycerate mutase
PF00300	$\"[2-160]T$	PGAM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1240	$\"[1-190]T$	G3DSA:3.40.50.1240
PIRSF001490	$\"[1-207]T$	DPGAM
PTHR23029	$\"[1-204]T$	PTHR23029
SSF53254	$\"[1-207]T$	SSF53254

","BeTs to 7 clades of COG0406COG name: Phosphoglycerate mutase/fructose-2,6-bisphosphataseFunctional Class: GThe phylogenetic pattern of COG0406 is ----YQvCEbR----------Number of proteins in this genome belonging to this COG is 4","***** IPB001345 (Phosphoglycerate mutase family) with a combined E-value of 6.2e-21. IPB001345A 3-32 IPB001345B 51-63 IPB001345C 74-105 IPB001345D 121-139","Residues 90-200 are 42% similar to a (PROTEOME PHOSPHOGLYCERATE COMPLETE MUTASE) protein domain (PD395696) which is seen in Q9CEU3_LACLA.Residues 6-88 are 43% similar to a (MUTASE PROTEOME COMPLETE PHOSPHOGLYCERATE PGAM) protein domain (PD000730) which is seen in Q9CEU3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:38:32 2002","Fri Dec 14 10:49:12 2001","Fri Oct 11 14:38:32 2002","Fri Dec 14 10:49:12 2001","Fri Dec 14 10:49:12 2001","Fri Dec 14 10:49:12 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0640 is paralogously related (blast p-value < 1e-3) to SMu1010, SMu1009, SMu0067, SMu1008, and SMu0543, all of which have properties of phosphoglycerate mutase.","Wed Jan 23 15:30:06 2002","","No significant hits to the NCBI PDB database.","SMU.700c","","Residues 1 to 197 (E-value = 9.2e-14) place SMu0640 in the PGAM family which is described as Phosphoglycerate mutase family (PF00300)","Fri Dec 14 10:49:12 2001","24379171","","","","","","1","","","SMU.700c","661" "SMu0641","663012","662644","369","ATGCGTTTATTAGGAAATATTGTTTGGTTTTTATGTGCTGGGTTATTATCTTTTATCGGTTGGTCTCTAGCGGGAATTATTCTTTGTCTGACTGTTATTCTCATTCCTTTTGGGCTTCAATGTTTTAAAATTGCAGGTTTTGGACTCTTTCCTTTTGGAAAATCGATTTCCCCTTCTAGCAATGTTTCCAGCCTTATTTTCAATATCATCTGGATTTTAGCCATTGGTTGGGAATTGGCGGTAATACACTTAGCATCTGCTTTCCTCCTTTGCATTACTATTATAGGAATTCCCTTTGCATTACAGTCTATCAAGATGGCTGGCATCAGCCTTTTTCCTTTTGGTATAACGATTATAAAAGAGGTATAA","8.50","3.03","13170","MRLLGNIVWFLCAGLLSFIGWSLAGIILCLTVILIPFGLQCFKIAGFGLFPFGKSISPSSNVSSLIFNIIWILAIGWELAVIHLASAFLLCITIIGIPFALQSIKMAGISLFPFGITIIKEV","662647","","integral membrane protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypotheticals and integral membrane protein:residues 1-119 are 41% similar to conserved hypothetical in V.cholerae (gi|15601802|).Residues 1-120 are 37% similar to the protein in S.coelicolor (gi|10129706|).SMu0641 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005185
Family

Protein of unknown function DUF307
PIRSF028777	$\"[1-122]T$	UCP028777
PF03733	$\"[3-59]T$ $\"[65-121]T$	DUF307

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 68-119 are 47% similar to a (PROTEOME COMPLETE PM0393 VCA1051) protein domain (PD021079) which is seen in Q9F2V1_STRCO.Residues 65-119 are 49% similar to a (PROTEOME COMPLETE) protein domain (PD174932) which is seen in O53882_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:33:29 2002","Wed Jan 23 15:31:32 2002","Fri Oct 11 14:39:07 2002","Fri Dec 14 12:34:10 2001","","Fri Dec 14 12:34:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0641 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 12:34:34 2001","","No significant hits to the NCBI PDB database.","SMU.701c","","Residues 3 to 59 (E-value = 3.1e-14) place SMu0641 in the DUF307 family which is described as Domain of unknown function (DUF307) (PF03733)Residues 65 to 121 (E-value = 1.8e-16) place SMu0641 in the DUF307 family which is described as Domain of unknown function (DUF307) (PF03733)","Fri Dec 14 12:34:10 2001","24379172","","","","","","1","","","SMU.701c","" "SMu0642","663490","663017","474","ATGAGCAAGAAAAAGAAATTAAAGAAAACCTTGGTTGAGCAAATTTTAGATAAGGCTAAGATTAAACATGACAGCTTAGCACTCAATGCCTTAGAAGGCAAATTGCCAGAAGATATCCAAAAGGAGGATATTTTTAAAACACTGGCACTAACTGGCGATAAAACTGGACCACTTATTGGGATTATTCCCATAACAGAACATCTTTCTGAAAAGAAATTAGCCAAAGTATCTGCAAATAAAAAAGTTACCATGATTCCCCAAAAAGAACTCCAAAAAATAACAGGCTATGTTCATGGTGCTAATAATCCTGTTGGTATTAGACAAAAGCATCATTTTCCAATTTTTATTGATTCTATAGCTTTAGAAAAAGGACAAATCATTGTATCAGCAGGTGAGATAGGACGTTCCATTCGTATCAACAGCCAAGTTTTAGCTGACTTTGTTGGAGCTCAATTTGCTGATTTGAAGGAGTGA","10.40","9.20","17294","MSKKKKLKKTLVEQILDKAKIKHDSLALNALEGKLPEDIQKEDIFKTLALTGDKTGPLIGIIPITEHLSEKKLAKVSANKKVTMIPQKELQKITGYVHGANNPVGIRQKHHFPIFIDSIALEKGQIIVSAGEIGRSIRINSQVLADFVGAQFADLKE","663020","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transcription regulator: residues 1-157 are 79% similar to the protein in S.pyogenes (gi|15674682|). Residues 1-157 are 70% similar to the protein from Lactococcus lactis subsp.lactis (gi|15672298|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0753 (2e-67).","

InterPro
IPR007214
Domain

YbaK/prolyl-tRNA synthetase associated region
PF04073	$\"[18-155]T$	YbaK

noIPR
unintegrated

unintegrated
G3DSA:3.90.960.10	$\"[9-155]T$	G3DSA:3.90.960.10
SSF55826	$\"[6-155]T$	SSF55826

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 28-139 are 74% similar to a (PROTEOME COMPLETE TRANSCRIPTION) protein domain (PD009524) which is seen in Q9CIP0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:39:55 2002","Fri Dec 14 14:40:41 2001","Fri Oct 11 14:39:55 2002","Fri Dec 14 14:40:41 2001","","Fri Dec 14 14:40:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0642 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 14:41:12 2001","","No significant hits to the NCBI PDB database.","SMU.702c","","Residues 18 to 155 (E-value = 5.8e-51) place SMu0642 in the YbaK family which is described as YbaK / prolyl-tRNA synthetases associated domain (PF04073)","Fri Dec 14 14:40:41 2001","24379173","","","","","","1","","","SMU.702c","662" "SMu0643","664329","663487","843","ATGATTTCTTGGTTAACAAGATTGATCAAAGGTGTTATCATTGCTCTTGGGTTTATTTTACCCGGTGTATCAGGCGGTGTTTTAGCATCTATTTTAGGATTGTATGAACGTATTATTTCATTTTTAGCACATTTGTCAAAAGATTTTGTTAAAAATGTTCTCTTTTTTATTCCTGTTGGAATTGGTGGTATTTTAGGTATCGCTCTTTTTTCAGCGCCTTTAGAATATCTGCTGGAACATTATCAAGTTCCCGTTCTGTGGGCCTTTACAGGAACAATCGTCGGAACCTTACCAAGCTTATTTTCTGAATCAACTCAAAAATCCAGACGTGACAACAAGGATTGGATTTGGCTGCTAGGAACTTTTATCATTTCTGGTCTCCTATTGTTCTTTTTAAATGATTTAATTGGGACAATTCCTGCTAACTTTGTTAGCTTTATTCTTGCTGGTGCTCTGATTGCCTTAGGTGTGTTAGTTCCAGGGCTTAGTCCGTCTAATCTCCTTTTAATTATGGGACTCTACACCCCTATGCTGACAGGTTTTAAGAACCTTGATTTAGTAGGAGTTTTTCTTCCAATTGCTATTGGCGGTGCTACGACCATGCTGCTTTTTTCAAAGGCCATGGATTATGCTCTCAATCACTACCATTCACGCGTTTATCACTTCATCTTAGGACTTGTTATTTCGAGTACCCTCTTAATCATTATTCCAAATCCTAGAAATACCGAAAGTATCTCTTATGCTGGCAGTAGCTTTACAACCTTTTTAATGGCTGCTCTGCTCTTTATAGCAGGTATTGCTCTGGGAGCTTGGATGAGTAAACTTGAGGAAAAATATAAATGA","9.90","4.19","30446","MISWLTRLIKGVIIALGFILPGVSGGVLASILGLYERIISFLAHLSKDFVKNVLFFIPVGIGGILGIALFSAPLEYLLEHYQVPVLWAFTGTIVGTLPSLFSESTQKSRRDNKDWIWLLGTFIISGLLLFFLNDLIGTIPANFVSFILAGALIALGVLVPGLSPSNLLLIMGLYTPMLTGFKNLDLVGVFLPIAIGGATTMLLFSKAMDYALNHYHSRVYHFILGLVISSTLLIIIPNPRNTESISYAGSSFTTFLMAALLFIAGIALGAWMSKLEEKYK","663490","","conserved hypothetical protein","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-280 are 62% similar to the protein in S.pyogenes (gi|15675907|)and are 59% similar to the protein from S.pneumoniae (gi|15902933|).SMu0643 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007163
Family

Protein of unknown function DUF368
PF04018	$\"[4-270]T$	DUF368

","BeTs to 4 clades of COG2035COG name: Predicted membrane proteinFunctional Class: SThe phylogenetic pattern of COG2035 is --t---v---------ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 3-101 are 30% similar to a (PROTEOME COMPLETE VCA0040 VNG1069C) protein domain (PD131594) which is seen in Q9KNC5_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 15:34:24 2002","Fri Dec 14 12:41:38 2001","Wed Jan 23 15:34:24 2002","Fri Dec 14 12:41:38 2001","","Fri Dec 14 12:41:38 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0643 is paralogously related (blast p-value < 1e-3) to SMu1519, a predicted branched-chain amino acid ABC transporter permease protein.","Wed Jan 23 15:34:07 2002","","No significant hits to the NCBI PDB database.","SMU.703c","","Residues 4 to 270 (E-value = 2e-106) place SMu0643 in the DUF368 family which is described as Domain of unknown function (DUF368) (PF04018)","Fri Dec 14 12:41:38 2001","24379174","","","","","","1","","","SMU.703c","" "SMu0644","665356","664373","984","ATGGTTATGGTCAAAAAGAAAAAATGTAAAAAGCAACTGACTAGTCATCAAAGGCGCCCTTATAAAAAGAAAAAGCAAGTTAACTATCATATGATAATCGTTTCTTTGCTTATACTACTTGGATTTAGTGGTCTTCTTTACCAACATCGTTTTCATATTTCCAACTCTTATGAAATAACGCAAACAGCTACAATTACACCAACATCACCAGTAACACTCTATTGCCATTTATTCGATTTTAATACAGATAAATTGAAACAAACTACTACAGTGCAAGTGACAGGCTATCGTTTAACACATCTAAGAGGAAAAACAATGACTTTGGCCAAGGTAAAATTAAGGGGACACACTTACTACCTTGATGCTAAACATCTTCAGATTCAACATACAAATGCAATCAATCAGTATATTGCCAGTTTAAACTATCCTCATACCGAAATAACCAAAAATATCTATCATCAGTTTGCCCAAAAATCCTATTTTGGAACAAGTGGTAAACCAAAGGGCATTATTATTCATGATACTGGAAATGACAGTTCTTCTATCCAAAGTGAAGTGGCCTATATGGAAAAAAATTATAAATCAACTGGGGTATTTGTTCATAGTTTTCTTGATAAAAATAATATTTTACAAATTGCTGATGACAGTTATATGGCTCAGGGAGCTGGTCCCAAAGGAAATCCTTATTATTTACAATTCGAAATGACGCATGAGCACAATAAGGATGATTTCGCTAGACAAACAGCTAATGCAGCCTACTATGCAGCTTTTATGCTTAAAAAATATAAATTGCCTGTCACTTTAAGGCAAAAAAATACATCAGGAACAGTTTGGACACATCAAATGGTTTCTTCTTATCTTGGCGGAACTGATCATCAAGATCCTGATGATTATTGGGCACAGGCTGCTGCAGATTTTTTTGCTAGCTCTTATTCTATTAAAAATTTTGTAGACTTAATTCAGGCCTATTATAATCAACTTTAA","10.30","19.98","37611","MVMVKKKKCKKQLTSHQRRPYKKKKQVNYHMIIVSLLILLGFSGLLYQHRFHISNSYEITQTATITPTSPVTLYCHLFDFNTDKLKQTTTVQVTGYRLTHLRGKTMTLAKVKLRGHTYYLDAKHLQIQHTNAINQYIASLNYPHTEITKNIYHQFAQKSYFGTSGKPKGIIIHDTGNDSSSIQSEVAYMEKNYKSTGVFVHSFLDKNNILQIADDSYMAQGAGPKGNPYYLQFEMTHEHNKDDFARQTANAAYYAAFMLKKYKLPVTLRQKNTSGTVWTHQMVSSYLGGTDHQDPDDYWAQAAADFFASSYSIKNFVDLIQAYYNQL","664376","The carboxyl terminal end matches closely a fibronectin binding autolysin in two Staphylococcus, S. caprae and S. epidermidis, see Allignet et al. (2001).","autolysin","Extracellular","Matches in gapped BLAST to primarily autolysin-related proteins. Residues 128-324 are 39% similar to gi|13272276 from S.caprae. Residues 133-327 are 36% similar to residues 85-270 of L.innocua.SMu0644 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002502
Domain

N-acetylmuramoyl-L-alanine amidase, family 2
PF01510	$\"[159-310]T$	Amidase_2
SM00644	$\"[153-296]T$	Ami_2

noIPR
unintegrated

unintegrated
SSF55846	$\"[140-326]T$	SSF55846

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 170-298 are 42% similar to a (AMIDASE HYDROLASE ALL) protein domain (PD016468) which is seen in O33635_STAEP.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 25 17:10:05 2002","Thu Apr 25 17:09:38 2002","Fri Oct 11 14:41:59 2002","Fri Mar 22 15:10:09 2002","","Fri Mar 22 15:10:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0644 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Apr 24 14:32:03 2002","","No significant hits to the NCBI PDB database.","SMU.704c","","Residues 156 to 310 (E-value = 1.1e-17) place SMu0644 in the Amidase_2 family which is described as N-acetylmuramoyl-L-alanine amidase (PF01510)","Fri Mar 22 15:10:09 2002","24379175","","","Allignet J, Aubert S, Dyke KG, El Solh N, Staphylococcus caprae strains carry determinants known to be involved in pathogenicity: a gene encoding an autolysin-binding fibronectin and the ica operon involved in biofilm formation, Infect Immun 2001 Feb;69(2):712-8, PMID: 11159959.","","Thu Apr 25 17:05:49 2002","1","","","SMU.704c","" "SMu0645","666060","665446","615","ATGAACACACATGGACTCCTTGGATTGTACAAGGAGGTCTTTTTTATGTCTAAAAATGCTGTTATTCTGGTTGAAACCGCTCTGATTGCCGCCTTAGCTATGGTTCTTTCAATGATACCTGACTTTGCAAGTTGGTTTACACCCTCTTTTGGAGCTATTCCCCTTGTCTTATTCGCCTTAAGAAGAGGAAGTAAATTTGGAGTTCTGGCAGGCTTCCTTTGGGGATTGCTGCATTTTCTTTTAGCAAAAGTTTATTATCTAACGCTTTCACAAGTATTTCTTGAATACATCTTAGCTTTCTTCTGCATGGGATTGGCAGGTATAACTAAACAGCCCTTTCAAACAGCCTTGAAAAATGGAAATAAGCTGAAAGCATTGCTCTTTGCCATACTAGGCGCATTCATAGCTATCTTCACCAGATATGTCTGTCATTATATCGCAGGTTTCCTTTTTTGGGGAAGTTATGCCCCCAAAGGAATGTCTCCTTTTTGGTACTCCTTCACTGTTAATGGCAGTGCTGGCTTGCTTACCTTTTTAGTTGTTATTCTTATCCTTGTGTTTTTAGTTATAAGCCAGCCACAACTCTTTTTACCAGCTGAAAAGAAGAACATATAA","10.50","9.60","22661","MNTHGLLGLYKEVFFMSKNAVILVETALIAALAMVLSMIPDFASWFTPSFGAIPLVLFALRRGSKFGVLAGFLWGLLHFLLAKVYYLTLSQVFLEYILAFFCMGLAGITKQPFQTALKNGNKLKALLFAILGAFIAIFTRYVCHYIAGFLFWGSYAPKGMSPFWYSFTVNGSAGLLTFLVVILILVFLVISQPQLFLPAEKKNI","665449","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical and unknowns:residues 19-200 are 50% similar to the conserved hypothetical protein in S.pyogenes (gi|15674683|).Residues 17-198 are 37% similar to an unknown in Listeria monocytogenes (gi|16803469|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0817 (1e-54).","

InterPro
IPR012651
Family

Thiamine transporter YuaJ
TIGR02357	$\"[20-199]T$	thia_yuaJ

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 11-106 are 40% similar to a (COMPLETE PROTEOME CDS ANTIGEN) protein domain (PD032447) which is seen in Q9CIN9_LACLA.Residues 17-108 are 35% similar to a (PROTEOME COMPLETE BH0830) protein domain (PD286566) which is seen in Q9KEM2_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 15:51:46 2002","Fri Dec 14 12:48:17 2001","Tue Mar 19 14:39:01 2002","Fri Dec 14 12:48:17 2001","","Fri Dec 14 12:48:17 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0645 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 23 15:34:54 2002","","No significant hits to the NCBI PDB database.","SMU.706c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 12:48:17 2001","24379176","","","","","","1","","","SMU.706c","918" "SMu0646","667065","666217","849","ATGAGAAGAAGAATTAAGCCTGTCTTTGTTCTAGCTTTCTTTAGTTTGTTCGCCTTGATTATCATCTTAGGGAATATTCAAGCTGAAAATGCCCGACAAAAAGAATTAAGAGCTGCCCAAGCAGCCATTCCTGCTACAGAACAAAATTCAGAGAAAGCTAAAGCAAAAAATTCAGATGGAGACACCTTTACTCTTAATCCGATTGTTGATATCTCGGGTTGGCAGCTGCCTAGCGAAATTGACTATGATACCCTATCAAAAAACATTTCAGGAGCTATTGTCCGCGTCCAAGGCGGGTCAGGCATCGCCAAAAAAAATAATGCAGCTCACAGTTCCGGAATTGATAAATCGTTTAAGACCCATATTGAAGAGTTCCAAAAACGCGGCATACCTGTGGCCGTCTATGCTTATGTCCGTGGATCCAGCGTCAAAAAAATGAAAGCTGAAGCAAAGACTTTTTACAAAAATGCATCTCCCTATAATCCAACTTTCTATTGGCTCGATGTTGAAGAAAAGACAATGCCTAACATGGACAAGGGAGTTAAAGCTTTTCGAGATGAATTAAAACGCCTTGGTGCTGAAAAAGTTGGTATTTACATTGGGACTTATTTTATGGAAGAGCACAGTATTTCAGCAAAAGGTTTTGACGCCATTTGGATTCCAACTTATGGTACTGACTCGGGCTACTTTGAAGCAGTCCCTAAAACCAAATTGAATTATGATCTGCATCAATACACCTCTCAAGGTCATATTGAAGGCTTCAAGAATACACTTGATCTTAATCAAATCGCCGTCAACAAAGATACAAAATCTACTTATGAAAAATTATTTGGATCAAGCAACCAATAA","9.50","2.71","17199","MRRRIKPVFVLAFFSLFALIIILGNIQAENARQKELRAAQAAIPATEQNSEKAKAKNSDGDTFTLNPIVDISGWQLPSEIDYDTLSKNISGAIVRVQGGSGIAKKNNAAHSSGIDKSFKTHIEEFQKRGIPVAVYAYVRGSSVKKMKAEAKTFYKNASPYNPTFYWLDVEEKTMPNMDKGVKAFRDELKRLGAEKVGIYIGTYFMEEHSISAKGFDAIWIPTYGTDSGYFEAVPKTKLNYDLHQYTSQGHIEGFKNTLDLNQIAVNKDTKSTYEKLFGSSNQ","666220","","endolysin","Extracellular","Matches in gapped BLAST to endolysin, phage associated/hypothetical protein: residues 1-150 are 72% similar to the endolysin, phage associated in S.pyogenes (gi|15674684|). Residues 1-146 are 57% similar to hypothetical protein from S.pneumoniae (gi|15902934|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0755 (2e-65).","

InterPro
IPR002053
Family

Glycoside hydrolase, family 25
PD004620	$\"[4-122]T$	Q81YZ2_BACAN_Q81YZ2;
PF01183	$\"[36-123]T$	Glyco_hydro_25

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[1-147]T$	no description

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-132 are 45% similar to a (PROTEOME COMPLETE) protein domain (PD130120) which is seen in Q9CGF6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Apr 24 14:33:13 2002","Thu Apr 25 17:16:32 2002","Fri Oct 11 14:44:36 2002","Fri Dec 14 12:52:03 2001","","Fri Dec 14 12:52:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0646 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 12:52:32 2001","","No significant hits to the NCBI PDB database.","SMU.707c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 12:52:03 2001","24379177","","","","","","1","","","SMU.707c","783" "SMu0647","667339","667863","525","ATGGAGAAGAAAACCTTAAAGCAAATTAGTCGTATTGCTATTTTGTCAGCTTTAGCCATTGTTTTGCGGCTTGCCTTTTCAGCTTTGCCCAATATTCAACCTATCACTGCTATCTTTCTAGTATGTGCCGTTTTTTATGGTTTTTGGGAAAGTTTTTTAATCATGACTGTAACCATGTTGATTACTAGTTTTTTGTTGGGATTCGGTCCTTGGGTCTTGGGGCAACTTATCAGCTTTGGTCTAGTTATTTGCCTTTGGAAATTTTGCCTTTATCCTATGACAAAACTTTTTCGATTTGGTAATATTAATGGTCTTGGTCTGCAGTCTGTTTTGGCAGGGTTAATGGGAATTGTATATGGTATCTTGATTGATACTTATTCTGCTCTCTTATTTTCTACTCCAATTTTAGCCTATATCATAGCAGGAATGACTTTTAATTTAGCTCATGCTATCTCGACTTTGTTCTTTTACCCAATTATATTATCAATCTTTAGGAGGTTATTGTCTCATGAAAAAAATAATTAA","10.40","7.32","19440","MEKKTLKQISRIAILSALAIVLRLAFSALPNIQPITAIFLVCAVFYGFWESFLIMTVTMLITSFLLGFGPWVLGQLISFGLVICLWKFCLYPMTKLFRFGNINGLGLQSVLAGLMGIVYGILIDTYSALLFSTPILAYIIAGMTFNLAHAISTLFFYPIILSIFRRLLSHEKNN","667862","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical and unknown proteins: residues 26-172 are 46% similar to the protein in S.pyogenes (gi|15674685|) and residues 26-174 are 33% similar to the protein in Lactococcus lactis (gi|15673154|) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0756 (2e-43).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-27]?$	signal-peptide
tmhmm	$\"[12-30]?$ $\"[36-54]?$ $\"[64-86]?$ $\"[105-123]?$ $\"[125-145]?$ $\"[151-169]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 26-174 are 33% similar to a (PROTEOME COMPLETE) protein domain (PD399805) which is seen in Q9CGC5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:40:56 2002","Fri Dec 14 12:54:58 2001","Tue Mar 19 14:40:56 2002","Fri Dec 14 12:54:58 2001","","Fri Dec 14 12:54:58 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0647 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 23 16:01:46 2002","","No significant hits to the NCBI PDB database.","SMU.709","","No significant hits to the Pfam 11.0 database","Fri Dec 14 12:54:58 2001","24379178","","","","","","1","","","SMU.709","915" "SMu0648","667847","668236","390","ATGAAAAAAATAATTAATGTTATCGTCTTATCACTATCCGTTTTTTTCCTGATAGCTTGCAGCAATAGCAGTACCGGGGAAAAAACAAGTCAATCATCTGAAGAGACTAAGGTCCGATTAATTGTTAAAACGGATTCTAATAAAACCGATGAAAAAGTCGCTTTCAAAAAAGGTGCTACTGTTATGGATGTCTTAAAAGACAACTATAAAGTTAAAGAAAGCGGTGGTTTTATCACTACTATTGATGGTGTCACTCAGGATAAAAAAGCAGGTAGGTACTGGATGTTTGATGTTAATGATAAGCTGGCATCAAAAGCTGCTGATAAGATTAAGGTCAAAAATGGGGATAAAATTGAATTTTATTTGAAAGTTTATAAAGGTAAGAACTAG","10.40","8.94","14382","MKKIINVIVLSLSVFFLIACSNSSTGEKTSQSSEETKVRLIVKTDSNKTDEKVAFKKGATVMDVLKDNYKVKESGGFITTIDGVTQDKKAGRYWMFDVNDKLASKAADKIKVKNGDKIEFYLKVYKGKN","668235","","conserved hypothetical protein","Periplasm, Membrane, Extracellular","Matches in gapped BLAST to hypothetical and unknowns: residues 1-125 are 51% similar to the protein in S.pyogenes (gi|15674686|) and are 30% similar to an unknown in Lactococcus lactis (gi|15673153|) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0757 (2e-36).","

noIPR
unintegrated

unintegrated
PS51257	$\"[1-20]T$	PROKAR_LIPOPROTEIN

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-125 are 30% similar to a (PROTEOME COMPLETE) protein domain (PD396951) which is seen in Q9CGC6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:42:33 2002","Fri Dec 14 12:57:01 2001","Tue Mar 19 14:42:33 2002","Fri Dec 14 12:56:47 2001","","Fri Dec 14 12:56:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0648 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 12:57:01 2001","","No significant hits to the NCBI PDB database.","SMU.711","","No significant hits to the Pfam 11.0 database","Fri Dec 14 12:56:47 2001","24379179","","","","","","1","","","SMU.711","916" "SMu0649","668354","671077","2724","GTGACAATCAACAAACTAGAAAGTAGAAATGATAAAGAAGCAATTGCTGAGGAGATTACTATTCTTACCAAACTACTGGACGATGCTACCAAAACAATGGTTGGCAGTGCTAGCTTTGATAAGATTACCCTCTTTAAAAAATTATCAATTGAAGAGAAGCATCAAGAGTTAGAACGTGAAATTGAGCAGTTAACAAATGAAGAAATGGTCGTTGTTTCTCGTTATTTCTCCATTTTACCGCTTCTTATCAATATTTCTGAAGATGTCAATTTAGCTTATGAAATCAACTATCAAAACAATAATGATATTGATTATTTAGGGAAATTATCAGCCACTATTGAACTTGTTTCTAGTCAAAAAAATGCTCAAGAAATTCTGGAAAATGTTAATGTTGTCCCTGTTCTAACAGCGCATCCAACTCAAGTGCAGCGAAAAACGATGCTGGATTTAACTAATCATATTCATGAACTTTTGCGTAAGTACCGTGATGTTAAAGCTGGATCTATTAACAAGCAAAAATGGTATGACGATATGCGCCGTTATGTTGAGCTCATTATGCAAACAGATATTATTCGTGAAAAGAAATTAAAAGTCACTAATGAAATTACTAATGTCATGGAATACTATAATTCCTCTCTGATTAAGGGTGTTACTAAATTAATTACAGAATACAAGCACTTGTCTCATCAAAAAGGATTTGATTTAGGAAATGCTAAACCAATTACGATGGGAATGTGGATTGGCGGTGACCGTGATGGGAATCCTTTCGTCACTGCTGAAACCCTGAAAATATCAGCTCTGGTGCAAAATGAAGTGATTTTAAATTATTATATTGACAAAGTTTCAGATCTTTATCGAACATTTTCTCTTTCAACCAGCCTTTCTACTATTAGCAATGCAGTTAAAGAGATGGCAGATCGTTCAACGGATGTTTCGATTTACCGAGAAAAAGAACCCTATCGTAAGGCTTTTCATTATATTCAATCAAGATTGCAAGAGACTCTTATTTATTTAAAAAACAACCATTTAGAAGAGTTGGAGTCTGAAGATAGTGCTCAAATCCTTCCTTATCAATCAGCGCAAGAGTTTAGAAATGATTTGCAACTCATCAAAGATTCTCTTTTAGAAAATAACGGTTCTGCTTTTATTACGGGTGATTTAACAGAATTATTGCAGGCAGTTGATGTTTTTGGTTTCTTTTTAGCTTCTATTGATATGCGACAAGATTCCAGTGTTCACGAAACCTGTGTAGCAGAACTGTTAGCTTCAGCCAATATTGTTGCTAACTATAGCGACTTACCTGAAGAAGAAAAGATTGCTATTCTTCTCAAAGAATTGACTGAAGATCCTCGAATACTGTCTGCAACGCATGTTGAAAAATCGGAAATATTGCAAAAGGAATTAGCTATTTTTAAAACAGCTAGGAAATTGAAGGATGCTCTGGGAGAAGATGTGATTAAACAACATATCATTTCACACACAGAAAGCATTTCTGATATGTTTGAATTAGCTATCATGCTCAAAGAAGTTGGCTTGGTTGATACAGATAAGGCGCGTGTGCAAATTGTTCCTTTATTTGAAACCATTGAGGACTTGGATAATTCTCGCGAAATCATGAGACAGTATCTCAATTATGATATTGTTAAAAAATGGATTGCAGCCAATCATAATTATCAGGAAATTATGCTGGGTTACTCAGATTCTAACAAGGATGGTGGTTATTTATCGTCTGGCTGGGCGCTCTACAAAGCACAAAATGAATTGACAGAAATTGGTTATGATAATGGTGTTAAAATCACCTTTTTCCATGGACGCGGCGGTACTGTTGGACGTGGTGGCGGTCCATCTTATGAGGCTATTACATCACAGCCATTTGGTTCCATCAAGGATCGGATTCGTTTAACAGAACAGGGTGAGGTTATTGGTAATAAATATGGCAATAAGGATGTTGCATACTACAACCTGGAAATGCTGGTTTCAGCAACTCTTGATCGCATGGTGACAAGAAGGATTGTCAATTCAGATAACTTAGTCAATTATCGTTTAATCATGGATGAAATTGTTGCTGACAGTAATCTCATTTATCGTGATTTAGTTTTCGGAAACGAACATTTCTATGATTATTTCTTCGCAGCTAGTCCAATTCGCGAAGTTTCAAGTTTGAATATTGGTTCCCGTCCAGCAGCTCGTAAGACGATTACAGAGATCAGCGGTTTGCGCGCTATTCCTTGGGTATTCTCATGGTCTCAAAATCGCATCATGTTTCCAGGATGGTACGGTGTTGGTTCAGCATTTAAACATTTTATAGATAAGGATGAAAAGAATTTGACTAAATTGCAGGAAATGTATCAATCATGGCCTTTCTTCCATTCATTGTTGTCAAATGTTGACATGGTTTTATCCAAATCAAATATGAATATTGCCTTTGAATATGCTAAATTATGTCAGGATGAAGAAACAAAAGAAGTCTTTGCAACTATTTTGGATGAATGGCAATTAACCAAAAATGTTATTCTAGCAATTGAAAGTCACAAACAGCTTTTAGAAGATAATAGTTATTTGAAAGCTAGTCTTGATTATCGTTTACCTTACTTTAATGTTTTAAATTATATTCAAATTGAGTTAATTAAACGTCAGCGCCGTGGTGAATTAGGTGAGAATTTAGAGAACCTGATTCACATTACTATTAATGGTGTCGCAACTGGTTTACGAAATTCAGGTTAA","5.10","-25.39","103860","MTINKLESRNDKEAIAEEITILTKLLDDATKTMVGSASFDKITLFKKLSIEEKHQELEREIEQLTNEEMVVVSRYFSILPLLINISEDVNLAYEINYQNNNDIDYLGKLSATIELVSSQKNAQEILENVNVVPVLTAHPTQVQRKTMLDLTNHIHELLRKYRDVKAGSINKQKWYDDMRRYVELIMQTDIIREKKLKVTNEITNVMEYYNSSLIKGVTKLITEYKHLSHQKGFDLGNAKPITMGMWIGGDRDGNPFVTAETLKISALVQNEVILNYYIDKVSDLYRTFSLSTSLSTISNAVKEMADRSTDVSIYREKEPYRKAFHYIQSRLQETLIYLKNNHLEELESEDSAQILPYQSAQEFRNDLQLIKDSLLENNGSAFITGDLTELLQAVDVFGFFLASIDMRQDSSVHETCVAELLASANIVANYSDLPEEEKIAILLKELTEDPRILSATHVEKSEILQKELAIFKTARKLKDALGEDVIKQHIISHTESISDMFELAIMLKEVGLVDTDKARVQIVPLFETIEDLDNSREIMRQYLNYDIVKKWIAANHNYQEIMLGYSDSNKDGGYLSSGWALYKAQNELTEIGYDNGVKITFFHGRGGTVGRGGGPSYEAITSQPFGSIKDRIRLTEQGEVIGNKYGNKDVAYYNLEMLVSATLDRMVTRRIVNSDNLVNYRLIMDEIVADSNLIYRDLVFGNEHFYDYFFAASPIREVSSLNIGSRPAARKTITEISGLRAIPWVFSWSQNRIMFPGWYGVGSAFKHFIDKDEKNLTKLQEMYQSWPFFHSLLSNVDMVLSKSNMNIAFEYAKLCQDEETKEVFATILDEWQLTKNVILAIESHKQLLEDNSYLKASLDYRLPYFNVLNYIQIELIKRQRRGELGENLENLIHITINGVATGLRNSG","671076","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). From Genbank:[gi:13637885]This enzyme is involved in the formation of oxaloacetate,a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.","phosphoenolpyruvate carboxylase","Cytoplasm","Several matches in gapped BLAST to phosphoenolpyruvate carboxylase: residues 1-907 are 67% similar to the enzyme in S.pneumoniae (gi|15903018|). Residues 3-907 are 66% similar to the protein from S.pyogenes (gi|15674689|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0759 (0.0).","

InterPro
IPR001449
Family

Phosphoenolpyruvate carboxylase
PR00150	$\"[133-146]T$ $\"[186-202]T$ $\"[243-258]T$ $\"[397-417]T$ $\"[559-579]T$ $\"[601-630]T$ $\"[736-762]T$	PEPCARBXLASE
PF00311	$\"[2-907]T$	PEPcase
PS00393	$\"[561-573]T$	PEPCASE_2
PS00781	$\"[134-145]T$	PEPCASE_1

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.60	$\"[155-669]T$	no description

","No hits to the COGs database.","***** IPB001449 (none) with a combined E-value of 3.7e-180. IPB001449A 61-96 IPB001449B 128-182 IPB001449C 235-281 IPB001449D 305-337 IPB001449E 375-429 IPB001449F 473-527 IPB001449G 544-597 IPB001449H 598-646 IPB001449I 725-766 IPB001449J 775-820 IPB001449K 844-882 IPB001449L 886-907 IPB001449B 31-85","Residues 15-907 are 37% similar to a (CARBOXYLASE PHOSPHOENOLPYRUVATE LYASE CARBON DIOXIDE) protein domain (PD001820) which is seen in CAPP_RHOPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 08:11:52 2002","Fri Dec 14 13:00:13 2001","Tue Oct 29 08:11:52 2002","Fri Dec 14 13:00:13 2001","Fri Dec 14 13:00:13 2001","Fri Dec 14 13:00:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0649 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 13:00:45 2001","Fri Dec 14 13:00:13 2001","pdb|1FIY| Three-Dimensional Structure Of Phosphoenolpyruvate ... 345 2e-095","SMU.712","","Residues 2 to 907 (E-value = 6.1e-95) place SMu0649 in the PEPcase family which is described as Phosphoenolpyruvate carboxylase (PF00311)","Fri Dec 14 13:00:13 2001","24379180","","","Inui,M., Dumay,V., Zahn,K., Yamagata,H. and Yukawa,H.Structural and functional analysis of the phosphoenolpyruvatecarboxylase gene from the purple nonsulfur bacteriumRhodopseudomonas palustris No. 7J. Bacteriol. 179 (15), 4942-4945 (1997)PubMed: 9244286O'Regan,M., Thierbach,G., Bachmann,B., Villeval,D., Lepage,P.,Viret,J.F. and Lemoine,Y.Cloning and nucleotide sequence of the phosphoenolpyruvatecarboxylase-coding gene of Corynebacterium glutamicum ATCC13032Gene 77 (2), 237-251 (1989)PubMed: 2666264Eikmanns,B.J., Follettie,M.T., Griot,M.U. and Sinskey,A.J.The phosphoenolpyruvate carboxylase gene of Corynebacteriumglutamicum: molecular cloning, nucleotide sequence, and expressionMol. Gen. Genet. 218 (2), 330-339 (1989)PubMed: 2779518","","Tue Oct 29 08:11:52 2002","1","","","SMU.712","80" "SMu0650","671372","672649","1278","ATGAAAATTGATAAGCGGCATTTGCTGAATTATTCGATATTATTGCCCTATTTAATTTTATCAGTGTTAGGTTTGATTGTTGTTTATTCAACAACCAGTGCTAGCTTAATACAAAATGGTTTAAATCCTTTTCGTTCTGTCATAAATCAGGCTGCCTTTTGGGTTATTAGTTTATTGGCTATCCTTTTTATTTACCGCTTAAAATTAAATTTTTTGAAGAACAGTGGTGTTTTAACTGTTATGATGATGATAGAAGTGGTGCTGCTTTTAATTGCGCGTTTTTGGACACAGGAAGTTAATGGTGCTCATGGTTGGATAGTTATTGGTCCCATCAGCTTTCAGCCGGCTGAGTATTTAAAAGTTATTATGGTCTGGTTTTTGGCTTTTACCTTTGCTAGGCGGCAGCAATCTATTGAAATTTATGATTATCAAGCTTTGACCAAACGTAAATGGTGGCCGAAGCAGTTGAGTGATCTAAAGGATTGGCGTTTTTATTCTTTAGTTTTGATTCTTTTGGTTGCAGCACAGCCCGATTTGGGAAATGCGACCATTATTGTTTTAACAGCTATTATTATGTATTCAGTCAGTGGTATTGGCTATCGTTGGTTTTCTGCTTTATTAACTGGGATTATTACGTTATCAGCAATCTTCTTAGGTCTCATCAATATGGTTGGTGTTAAAACGATGAGCAAGGTTCCAGTTTTTGGCTATGTTGCTAAACGCTTTAGTGCTTTTTTCAATCCGTTTAAGGATGTGACAGACTCTGGACACCAGTTGGCTAATTCCTATTATGCTATGAGTAATGGTGGTTGGCTGGGACGTGGTTTGGGCAATTCTATTGAAAAGCGAGGCTATCTTCCAGAGGCACAAACGGATTTTGTCTTTTCAATTATTATTGAAGAATTAGGACTGATTGGAGCAGGACTCATTTTAGCCTTGATTTTCTTTTTGATTTTGCGTATTCTGCTAGTTGGTGTTAAAGCTAAAAATCCTTTTAACTCCATGATTGCTTTGGGTATTGGTTCTATGATGCTGATGCAGGTATTTGTCAATATTGGTGGAATATCCGGCCTTATTCCTTCAACAGGTGTAACTTTTCCCTTTCTATCACAGGGAGGAAACAGTCTTCTTGTTTTGTCGGTAGCTATTGGTTTTGTATTAAATATTGATGCTAATGAGAAACGAGAAGATATTTATCAGGAAGTGGAAGAAGCCGAGCGTGATGATACAGATGTTTTTATAGATCCTCAATCGCAACAGGAGACTTATGGAGAATAA","9.40","2.73","47453","MKIDKRHLLNYSILLPYLILSVLGLIVVYSTTSASLIQNGLNPFRSVINQAAFWVISLLAILFIYRLKLNFLKNSGVLTVMMMIEVVLLLIARFWTQEVNGAHGWIVIGPISFQPAEYLKVIMVWFLAFTFARRQQSIEIYDYQALTKRKWWPKQLSDLKDWRFYSLVLILLVAAQPDLGNATIIVLTAIIMYSVSGIGYRWFSALLTGIITLSAIFLGLINMVGVKTMSKVPVFGYVAKRFSAFFNPFKDVTDSGHQLANSYYAMSNGGWLGRGLGNSIEKRGYLPEAQTDFVFSIIIEELGLIGAGLILALIFFLILRILLVGVKAKNPFNSMIALGIGSMMLMQVFVNIGGISGLIPSTGVTFPFLSQGGNSLLVLSVAIGFVLNIDANEKREDIYQEVEEAERDDTDVFIDPQSQQETYGE","672648","For other 'fts' genes, see SMu0013 (ftsH); SMu0501 (ftsA);SMu0502(ftsZ);SMu0500 (ftsQ); SMu0676 (ftsY); SMu0411 (ftsL); SMu1209 (ftsX); SMu1210 (ftsE) and SMu1483 (ftsK). From Genbank:[gi:14285439]This is a septum-peptidoglycan biosynthetic protein,involved in cell wall formation.It plays a role in the stabilization of the FTSZ ring during cell division .","cell division protein","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to cell division protein: residues 1-410 are 72% similar to the protein in S.pyogenes (gi15674690). Residues 1-403 are 60% similar to the protein from S.pneumoniae (gi15900936).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0761 (1e-178).","

InterPro
IPR001182
Family

Cell cycle protein
PF01098	$\"[10-395]T$	FTSW_RODA_SPOVE

","BeTs to 11 clades of COG0772COG name: Bacterial cell division membrane protein FtsW/MrdB/SpoVEFunctional Class: DThe phylogenetic pattern of COG0772 is -----QVcEBRHUJ--OLINXNumber of proteins in this genome belonging to this COG is 2","***** IPB001182 (Cell cycle proteins) with a combined E-value of 9.1e-50. IPB001182A 101-118 IPB001182B 256-277 IPB001182C 285-306 IPB001182D 350-375","Residues 13-389 are 46% similar to a (CELL DIVISION COMPLETE PROTEOME) protein domain (PD003242) which is seen in FTSW_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 13:46:18 2006","Fri Sep 8 13:46:18 2006","Fri Sep 8 13:46:18 2006","Fri Dec 14 13:09:37 2001","Fri Dec 14 13:09:37 2001","Fri Dec 14 13:09:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0650 is paralogously related (blast p-value < 1e-3) to SMu1169, a predicted rod shape determining protein. ","Wed Jan 23 16:07:45 2002","","No significant hits to the NCBI PDB database.","SMU.713","","Residues 10 to 395 (E-value = 2.2e-89) place SMu0650 in the FTSW_RODA_SPOVE family which is described as Cell cycle protein (PF01098)","Fri Dec 14 13:09:37 2001","24379181","","","Ikeda,M., Sato,T., Wachi,M., Jung,H.K., Ishino,F., Kobayashi,Y. and Matsuhashi,M.Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectivelyJ. Bacteriol. 171 (11), 6375-6378 (1989)PubMed: 2509435","","Tue Mar 19 14:47:08 2002","1","","","SMU.713","318" "SMu0651","672868","674064","1197","ATGGCAAAAGAAAAATACGATCGTAGTAAACCACACGTTAACATTGGTACTATCGGACACGTTGACCATGGTAAAACTACCTTAACTGCAGCTATCACAACTGTACTGGCACGTCGTCTTCCAAGTGCAGTAAACCAACCAAAAGATTATTCATCTATTGATGCTGCTCCTGAAGAACGCGAACGCGGTATCACTATCAATACTGCGCACGTTGAGTATGAAACTGAAAAACGTCACTATGCTCACATTGATGCTCCAGGACACGCGGACTATGTTAAAAACATGATCACTGGTGCTGCCCAAATGGATGGTGCTATCCTTGTAGTAGCTTCAACTGATGGACCAATGCCACAAACTCGTGAACACATTCTTCTTTCACGTCAAGTTGGTGTTAAATACCTCATTGTCTTCATGAATAAAGTTGATTTGGTTGACGATGAAGAATTGCTTGAATTGGTTGAAATGGAAATCCGTGATCTTCTTTCAGAATATGATTTCCCAGGTGATGATATTCCAGTTATTCAAGGTTCAGCTCTTAAAGCTCTTGAAGGCGATACTGCTCAAGAAGATATCATCATGGAATTAATGCATACTGTTGATGACTACATTCCAGATCCAGAACGTGATACTGACAAGCCGCTCCTTCTTCCAGTCGAAGATGTTTTCTCAATCACTGGTCGTGGTACTGTTGCTTCAGGACGTATTGATCGTGGTACTGTTAAAGTTAACGATGAAGTTGAAATCGTTGGTATCCGTGATGACATTCAAAAAGCTGTTGTTACTGGTGTTGAAATGTTCCGTAAACAATTGGATGAAGGTATTGCAGGGGATAATGTTGGTGTTCTCCTTCGTGGTATCCAACGTGATGAAATCGAACGTGGTCAAGTTCTTGCTAAACCAGGTTCAATTCACCCACATACTAAATTCAAAGGTGAAGTTTATATCCTTACTAAAGAGGAAGGTGGACGTCATACACCATTCTTCAATAACTATCGTCCACAATTCTACTTCCGTACAACTGACGTAACTGGTTCAATTGAGTTGCCAGCAGGTACTGAAATGGTTATGCCTGGTGATAACGTTACTATTGACGTTGAATTGATCCATCCAATCGCTGTTGAACAAGGTACTACTTTCTCTATTCGTGAAGGTGGACGTACTGTTGGTTCTGGTATCGTTTCAGAAATCGAAGCTTAA","4.70","-23.82","43907","MAKEKYDRSKPHVNIGTIGHVDHGKTTLTAAITTVLARRLPSAVNQPKDYSSIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVASTDGPMPQTREHILLSRQVGVKYLIVFMNKVDLVDDEELLELVEMEIRDLLSEYDFPGDDIPVIQGSALKALEGDTAQEDIIMELMHTVDDYIPDPERDTDKPLLLPVEDVFSITGRGTVASGRIDRGTVKVNDEVEIVGIRDDIQKAVVTGVEMFRKQLDEGIAGDNVGVLLRGIQRDEIERGQVLAKPGSIHPHTKFKGEVYILTKEEGGRHTPFFNNYRPQFYFRTTDVTGSIELPAGTEMVMPGDNVTIDVELIHPIAVEQGTTFSIREGGRTVGSGIVSEIEA","674063","This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis [gi:416943].","translation elongation factor Tu","Cytoplasm","Matches in gapped BLAST to elongation factor Tu:residues 104-377 are 94% similar to the previously published protein in S.mutans (gi11612446). Residues 1-398 are 87% similar to the protein in S.oralis (gi416943)and are 86% similar to the protein from S.pneumoniae (gi15901337).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0762 (0.0).","

InterPro
IPR000795
Domain

Protein synthesis factor, GTP-binding
PR00315	$\"[14-27]T$ $\"[61-69]T$ $\"[81-91]T$ $\"[97-108]T$ $\"[134-143]T$	ELONGATNFCT
PF00009	$\"[10-207]T$	GTP_EFTU
PS00301	$\"[54-69]T$	EFACTOR_GTP

InterPro
IPR004160
Domain

Translation elongation factor EFTu/EF1A, C-terminal
PF03143	$\"[303-397]T$	GTP_EFTU_D3

InterPro
IPR004161
Domain

Translation elongation factor EFTu/EF1A, domain 2
PF03144	$\"[228-298]T$	GTP_EFTU_D2

InterPro
IPR004541
Family

Translation elongation factor EFTu/EF1A, bacterial and organelle
PTHR23115:SF31	$\"[1-332]T$	Transl_elong_EFTu/EF1A_bac/org
TIGR00485	$\"[1-398]T$	EF-Tu

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[10-193]T$	small_GTP

InterPro
IPR009000
Domain

Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447	$\"[206-306]T$	Translat_factor

InterPro
IPR009001
Domain

Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
SSF50465	$\"[306-398]T$	Elong_init_C

noIPR
unintegrated

unintegrated
G3DSA:2.40.30.10	$\"[209-339]T$ $\"[343-398]T$	G3DSA:2.40.30.10
G3DSA:3.40.50.300	$\"[2-206]T$	G3DSA:3.40.50.300
PTHR23115	$\"[1-332]T$	PTHR23115
SSF52540	$\"[7-229]T$	SSF52540

","BeTs to 17 clades of COG0050COG name: GTPases - translation elongation factors and sulfate adenylate transferase subunit 1Functional Class: J,EThe phylogenetic pattern of COG0050 is AMTKYQvcEbRHujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000795 (GTP-binding elongation factor) with a combined E-value of 5.5e-51. IPB000795A 14-29 IPB000795B 83-114 IPB000795C 118-142***** IPB000640 (Elongation factor G, C-terminus) with a combined E-value of 2e-15. IPB000640A 12-37 IPB000640B 53-75 IPB000640C 80-107 IPB000640E 195-206***** IPB000178 (Initiation factor 2) with a combined E-value of 1e-07. IPB000178A 11-49 IPB000178B 80-112 IPB000178C 113-152 IPB000178F 332-373","Residues 222-310 are 88% similar to a (FACTOR ELONGATION GTP-BINDING BIOSYNTHESIS EF-TU 1-ALPHA) protein domain (PD000168) which is seen in EFTU_STROR.Residues 59-92 are 85% similar to a (ELONGATION FACTOR GTP-BINDING) protein domain (PD173400) which is seen in Q9TJQ8_PROWI.Residues 312-363 are identical to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS EF-TU) protein domain (PD000655) which is seen in EFTU_STROR.Residues 59-92 are identical to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS 1-ALPHA) protein domain (PD350470) which is seen in EFTU_STROR.Residues 365-396 are identical to a (ELONGATION FACTOR GTP-BINDING) protein domain (PD404624) which is seen in EFTU_STRPY.Residues 365-395 are 77% similar to a (FACTOR ELONGATION GTP-BINDING) protein domain (PD335136) which is seen in Q9TLV8_CYACA.Residues 203-321 are 29% similar to a (FACTOR INITIATION GAMMA TRANSLATION) protein domain (PD006718) which is seen in IF2G_ARCFU.Residues 123-218 are 78% similar to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS EF-TU) protein domain (PD007358) which is seen in EFTU_STRPY.Residues 365-397 are 72% similar to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS EF-TU) protein domain (PD272279) which is seen in EFTU_BACHD.Residues 310-396 are 29% similar to a (FACTOR ELONGATION GTP-BINDING TU) protein domain (PD337982) which is seen in Q19072_CAEEL.Residues 1-58 are 72% similar to a (ELONGATION FACTOR GTP-BINDING BIOSYNTHESIS EF-TU) protein domain (PD187884) which is seen in EFTU_STROR.Residues 93-122 are identical to a (FACTOR ELONGATION GTP-BINDING BIOSYNTHESIS EF-TU 1-ALPHA) protein domain (PD000134) which is seen in EFTU_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 15 08:42:41 2002","Tue Aug 1 08:44:33 2006","Tue Aug 1 08:44:33 2006","Fri Dec 14 14:14:20 2001","Fri Dec 14 14:14:20 2001","Fri Dec 14 14:14:20 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0651 is paralogously related (blast p-value < 1e-3) to SMu0496, and SMu1271,both predicted GTP-binding proteins, SMu0324,a predicted translation elongation factor G, SMu0382,a predicted translation initiation factor and SMu0554, a predicted peptide chain release factor 3;translation elongation and release factor.","Tue Jan 15 08:49:37 2002","Tue Aug 1 08:44:33 2006","pdb1DG1G Chain G, Whole, Unmodified, Ef-Tu(Elongation Factor ... 553 2e-158pdb1D8TA Chain A, Crystal Structure Of Elongation Factor, Tu ... 551 6e-158pdb1EFCA Chain A, Intact Elongation Factor From E.Coli >gi46... 551 6e-158","SMU.714","","Residues 10 to 207 (E-value = 5.2e-100) place SMu0651 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)Residues 228 to 298 (E-value = 6.3e-25) place SMu0651 in the GTP_EFTU_D2 family which is described as Elongation factor Tu domain 2 (PF03144)Residues 303 to 397 (E-value = 9.6e-59) place SMu0651 in the GTP_EFTU_D3 family which is described as Elongation factor Tu C-terminal domain (PF03143)","Tue Aug 1 08:44:33 2006","24379182","","","Ludwig,W., Weizenegger,M., Betzl,D., Leidel,E., Lenz,T.,Ludvigsen,A., Mollenhoff,D., Wenzig,P. and Schleifer,K.H.Complete nucleotide sequences of seven eubacterial genes coding for the elongation factor Tu: functional, structural and phylogenetic evaluationsArch. Microbiol. 153 (3), 241-247 (1990)PubMed: 2110445Porcella,S.F., Belland,R.J. and Judd,R.C.Identification of an EF-Tu protein that is periplasm-associated and processed in Neisseria gonorrhoeaeMicrobiology 142 (Pt 9), 2481-2489 (1996)PubMed: 8828215Jones,M.D., Petersen,T.E., Nielsen,K.M., Magnusson,S.,Sottrup-Jensen,L., Gausing,K. and Clark,B.F.The complete amino-acid sequence of elongation factor Tu fromEscherichia coliEur. J. Biochem. 108 (2), 507-526 (1980)PubMed: 6997043Yokota,T., Sugisaki,H., Takanami,M. and Kaziro,Y.The nucleotide sequence of the cloned tufA gene of Escherichia coliGene 12 (1-2), 25-31 (1980)PubMed: 7011903Laursen,R.A., L'Italien,J.J., Nagarkatti,S. and Miller,D.L.The amino acid sequence of elongation factor Tu of Escherichiacoli. The complete sequenceJ. Biol. Chem. 256 (15), 8102-8109 (1981)PubMed: 7021545Nakamura,S., Nakayama,N., Takahashi,K. and Kaziro,Y.Primary structure of the polypeptide chain elongation factor Tufrom E. coli. I. Amino acid sequence of fragment BJ. Biochem. 91 (3), 1047-1063 (1982)PubMed: 7042700Kawashima,T., Berthet-Colominas,C., Wulff,M., Cusack,S. andLeberman,R.The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 AresolutionNature 379 (6565), 511-518 (1996)PubMed: 8596629Ke,D., Boissinot,M., Huletsky,A., Picard,F.J., Frenette,J.,Ouellette,M., Roy,P.H. and Bergeron,M.G.Evidence for Horizontal Gene Transfer in Evolution of ElongationFactor Tu in EnterococciJ. Bacteriol. 182 (24), 6913-6920 (2000)PUBMED 11092850","Tue Aug 1 08:44:33 2006","Tue Aug 1 08:44:33 2006","1","","","SMU.714","81" "SMu0652","674360","675118","759","ATGTCACGTAAACCAATTATTGCTGGTAACTGGAAAATGAACAAGACTGCTGCTGAAGCGCGTGAGTTCATTGATGCAGTTAAGAACAATATTCCTTCAAATAATCTTGTTGATACTGTTATTGGATCACCTGCATTATTCCTTGAAGGAATGAAAAAAGGCGTGAAAGGTACAGAATTGCAAGTTGCAGCTCAAAACTGTTACTGGGAAGATTTTGGTGCTTTTACTGGTGAAACAAGTCCTGCAGCGCTTGCAGCACTTGGTGTTGACTATGTTATTATTGGGCACTCAGAACGTCGTGATTACTTCCATGAAACAGATCAAGAGATTAACAAAAAAGCACATGCTATTTTTAAGCACAAGATGACGCCAATTCTTTGTTGTGGTGAATCTCTTGAAACTTATGAAGCAGGTAAAACAGCTGAATGGATTGAAGGACAAATCACTGCTGACCTTAAAGGTTTGAGTGCTGAGCAAGTATCAAGTATGGTTATCGCTTATGAACCAATCTGGGCTATTGGTACTGGTAAGTCAGCTGATGCTAATATTGCAGATGATATCTGTGGTGTTGTTCGTGCAACCGTTGAAAAACTTTATGGAAAAGAAGTTGCTCAGGCTGTCCGTATTCAATACGGCGGTTCTGTAAAACCAGAAAATGTTGCAGAATACATGGCTAAAGAAAATGTTGATGGTGCTCTTGTTGGCGGTGCTTCACTGCAAGCAGACAGTTTCCTTGCCCTTCTTGACTTTGTCAAATAA","4.90","-8.21","27197","MSRKPIIAGNWKMNKTAAEAREFIDAVKNNIPSNNLVDTVIGSPALFLEGMKKGVKGTELQVAAQNCYWEDFGAFTGETSPAALAALGVDYVIIGHSERRDYFHETDQEINKKAHAIFKHKMTPILCCGESLETYEAGKTAEWIEGQITADLKGLSAEQVSSMVIAYEPIWAIGTGKSADANIADDICGVVRATVEKLYGKEVAQAVRIQYGGSVKPENVAEYMAKENVDGALVGGASLQADSFLALLDFVK","675117","","triosephosphate isomerase","Cytoplasm","Matches in gapped BLAST to triosephosphate isomerase:residues 1-106 are 99% similar to the previously published enzyme in S.mutans (gi|1661197|). Residues 1-252 are 72% similar to the enzyme in Lactococcus lactis subsp. lactis (gi|15673116|)and are 66% similar to the protein from S.pneumoniae (gi|15901416|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0763 (1e-94).","

InterPro
IPR000652
Family

Triosephosphate isomerase
PD001005	$\"[3-235]T$	Triophos_ismrse
PTHR21139	$\"[1-252]T$	Triophos_ismrse
PF00121	$\"[5-248]T$	TIM
TIGR00419	$\"[6-242]T$	tim
PS00171	$\"[166-176]T$	TIM
SSF51351	$\"[2-251]T$	Triophos_ismrse

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[3-249]T$	Aldolase_TIM

","BeTs to 14 clades of COG0149COG name: Triosephosphate isomeraseFunctional Class: GThe phylogenetic pattern of COG0149 is amtkyqvcebrhujgpolin-Number of proteins in this genome belonging to this COG is 1","***** IPB000652 (Triosephosphate isomerase) with a combined E-value of 1.4e-88. IPB000652A 6-16 IPB000652B 73-113 IPB000652C 121-147 IPB000652D 164-188 IPB000652E 208-239","Residues 3-249 are 72% similar to a (ISOMERASE TRIOSEPHOSPHATE TIM FATTY) protein domain (PD001005) which is seen in TPIS_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 11 14:54:32 2002","Fri Dec 14 15:05:06 2001","Fri Oct 11 14:54:32 2002","Fri Dec 14 15:04:15 2001","Fri Dec 14 15:04:15 2001","Fri Dec 14 15:04:15 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0652 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 14 15:05:06 2001","Fri Dec 14 15:04:15 2001","pdb|2BTM|B Chain B, Does The His12-Lys13 Pair Play A Role In Th... 276 2e-075pdb|1BTM|B Chain B, Triosephosphate Isomerase (Tim) Complexed W... 275 4e-075pdb|1B9B|B Chain B, Triosephosphate Isomerase Of Thermotoga Mar... 217 9e-058","SMU.715","","Residues 3 to 252 (E-value = 1.4e-122) place SMu0652 in the TIM family which is described as Triosephosphate isomerase (PF00121)","Fri Dec 14 15:04:15 2001","24379183","","","Cancilla,M.R., Davidson,B.E., Hillier,A.J., Nguyen,N.Y. andThompson,J.The Lactococcus lactis triosephosphate isomerase gene, tpi, ismonocistronicMicrobiology 14PubMed: 7534588Branny,P., de la Torre,F. and Garel,J.R.An operon encoding three glycolytic enzymes in Lactobacillusdelbrueckii subsp. bulgaricus: glyceraldehyde-3-phosphatedehydrogenase, phosphoglycerate kinase and triosephosphateisomeraseMicrobiology 144 (Pt 4), 905-914 (1998)PubMed: 9579064Leyva-Vazquez,M.A. and Setlow,P.Cloning and nucleotide sequences of the genes encoding triosephosphate isomerase, phosphoglycerate mutase, and enolase fromBacillus subtilisJ. Bacteriol. 176 (13), 3903-3910 (1994)PubMed: 8021172","Fri Oct 11 14:54:32 2002","Fri Dec 14 15:09:17 2001","1","","","SMU.715","543" "SMu0653","676560","675328","1233","ATGGCTTTACAAAACATCTCTCAAAATGATTTTGCCTTACATGTTCAAAAAGCAGAGCAAAAATCTTTCATGCAGACCTTAGAAATGGCCAAGCTTCTTTCCAAAAGAGGATTTACGCTTAATTATATTGCTTGGTTAGAAAATGGAACAATTGAAATTTCTGCTATTTTATACAGCATGCCCATGACTGGCGGCCGCTATTTTGAAATTAATTGCGGACCAGTTGTCACACGAGATAAGCATCTAACAGATTTTTACAGAGAACTAAAAGACTATGTCAAAGAAAAAGGTGCTTTAGAATTAGTAATAAAACCTTATGACACCTATCAAACCTTTGATGGTGATGGCCAAGCAACCAGTGCTGAAAAAAAAGAACTTATCTCGCAATTAACTAATCTCGGTTATCATTTTGATGGCTTGCAGAGGGATTATCCTAATGGTGAACCTGATTGGCACTATGTCAAAGATTTATCGGATATTAGCGAACAAACACTGCTAAAATCCTTCAGTAAAAAAGGACGCCCTTTAGTAAAAAAAGCCAAAACTTTCGGCACTAAACTTCGTCGGCTTAATCGTGATGAGCTTAACCTCTTTAAGGAAATTACTTCAGCCACTTCTGATCGCAGAGAATACAGTGATAAAAGTCTGGACTACTACCAAGACTTTTACGATAGTTTTGGAAATAATGCCGAATTTATGATTGCCAGCCTCAACTTTGAAAATTATCTTAGTCATTTACAAAGGGATCAAAATAAACTTGGCAATAAAATTGCTAAGTTGCAAGCCGATTTGGAAAAAAATCCGCATTCTGAAAAAAAACAAAACCAATTGCGTGAACTGTCCAGCCAATTCGATACCTTTACAACTCGTCAAGAAGAAGCTCAGAAATTTATCACTAAATACGGCAAAAAGGATGTCATCTTAGCAGGCAGTCTCTTTGTTTATACACCTCAAGAAGCCGTCTATCTTTTCTCAGGTTCCTATCCAGAATTTAATAAGTTCTATGCGCCTGCTCTTCTACAAGAACATGTGATGCTTGAAGCTCTTAAAAGAGGAATTTCTTTTTATAATCTCCTTGGTATTACAGGGCACTTTGATAATTCAGATGGTGTTCTTCGTTTCAAACAAAATTTCAATGGTTACATTGTCCGCAAGATGGGAACATTCCATTATTATCCAAATCCCTTAAAATACAGACTTTTAAATACGATTAAAAAAATTCTAAGACGTTAA","9.90","10.14","47716","MALQNISQNDFALHVQKAEQKSFMQTLEMAKLLSKRGFTLNYIAWLENGTIEISAILYSMPMTGGRYFEINCGPVVTRDKHLTDFYRELKDYVKEKGALELVIKPYDTYQTFDGDGQATSAEKKELISQLTNLGYHFDGLQRDYPNGEPDWHYVKDLSDISEQTLLKSFSKKGRPLVKKAKTFGTKLRRLNRDELNLFKEITSATSDRREYSDKSLDYYQDFYDSFGNNAEFMIASLNFENYLSHLQRDQNKLGNKIAKLQADLEKNPHSEKKQNQLRELSSQFDTFTTRQEEAQKFITKYGKKDVILAGSLFVYTPQEAVYLFSGSYPEFNKFYAPALLQEHVMLEALKRGISFYNLLGITGHFDNSDGVLRFKQNFNGYIVRKMGTFHYYPNPLKYRLLNTIKKILRR","675333","For other 'mur' genes see SMu0549 (murF); SMu0654 (murM);SMu0883 (murB); SMu1529 (murE); SMu1566 (murI); SMu0498 (murD);SMu0499 (murG); SMu1577 (murC); SMu1304 (murC);SMu1386 (murA) and SMu1429 (murZ).","peptidoglycan branched peptide synthesis protein, alanine adding enzyme; methicillin resistance factor","Cytoplasm","Matches in gapped BLAST to beta-lactam resistance factor MurN: residues 1-410 are 60% similar to the protein in S.pneumoniae (gi15674251)and are 58% similar to the protein from S.pyogenes (gi15674693).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0508 (1e-142).","

InterPro
IPR003447
Family

Methicillin resistance protein
PF02388	$\"[6-406]T$	FemAB
PS51191	$\"[1-404]T$	FEMABX

InterPro
IPR010978
Domain

tRNA-binding arm
SSF46589	$\"[239-303]T$	tRNA_binding_arm

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[122-387]T$	G3DSA:3.40.630.30
SSF55729	$\"[1-159]T$ $\"[160-404]T$	SSF55729

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 231-309 are 62% similar to a (MURN FACTOR ZOOCIN FEMA) protein domain (PD400272) which is seen in Q9L388_STRPN.Residues 310-407 are 75% similar to a (RESISTANCE FEMA FACTOR METHICILLIN) protein domain (PD006172) which is seen in Q9L388_STRPN.Residues 234-314 are 29% similar to a (RESISTANCE METHICILLIN FEMA FACTOR) protein domain (PD356622) which is seen in Q9S6V4_STAHA.Residues 49-227 are 59% similar to a (RESISTANCE FACTOR FEMA METHICILLIN) protein domain (PD007011) which is seen in Q9L388_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 15:43:58 2006","Thu Sep 7 15:30:17 2006","Thu Sep 7 15:30:17 2006","Fri Dec 14 15:12:21 2001","","Fri Dec 14 15:12:21 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0653 is paralogously related (blast p-value < 1e-3) to SMu0654, a predicted beta-lactam resistance factor murM.","Wed Jan 23 16:31:32 2002","","No significant hits to the NCBI PDB database.","SMU.716c","","Residues 6 to 406 (E-value = 5.5e-113) place SMu0653 in the FemAB family which is described as FemAB family (PF02388)","Fri Dec 14 15:12:21 2001","","","","Webera,B., Ehlertb,K., Diehla,A., Reichmanna,P., Labischinskib,H.and Hakenbecka,R.The fib locus in streptococcus pneumoniae is required forpeptidoglycan crosslinking and PBP-mediated beta-lactam resistanceFEMS Microbiol. Lett. 188 (1), 81-85 (2000)PubMed: 10867238Smith,A.M. and Klugman,K.P.Alterations in MurM, a Cell Wall Muropeptide Branching Enzyme,Increase High-Level Penicillin and Cephalosporin Resistance inStreptococcus pneumoniaeAntimicrob. Agents Chemother. 45 (8), 2393-2396 (2001)PubMed: 11451707Filipe,S.R. and Tomasz,A.Inhibition of the expression of penicillin resistance inStreptococcus pneumoniae by inactivation of cell wall muropeptidebranching genesProc. Natl. Acad. Sci. U.S.A. 97 (9), 4891-4896 (2000)PubMed: 10759563","","Fri Dec 14 15:19:23 2001","1","","","SMU.716c","287" "SMu0654","677777","676563","1215","ATGTACACATATAAAATCGGAATTTCAAAAGAAGAACATGATAACTTTATCAAAAACAGCAGTCAAACCAATCTACTACAAAGCAGTTCTTGGGCAAAAGTTAAAGATGAATGGGAAAATGAGCGAATAGGTTTTTATCAAGATAGCAAACTTGTTGCCTCTGCCTCTATTTTAATCAGACCTTTACCTCTTGGTATGACAATGTTTTACATTCCAAGAGGTCCCGTTATGAACTATCAAGATAAAGATTTGGTGAATTTTGTATTGACCTCCTTAAAAAAGTTTGCCAAAAGAAAAAGAGCCCTATTTATTAAGTTTGATCCTTTTATTTTGCTGAACCATCATCAAATTGATGAGGAAGCCATCAATAACCCGCAAGCACAAACTATTATTGACACTTTAAAGCATTTAGGCTGTGAATGGCTGGGACAAACAAGTGATATGGGAGAAACTATTCAGCCGCGTTTCCAAGCCAATATCTACGCAGAAGGGTTCTCTGAAGCTAACTTATCCAAAAAAATCCGACAATCCATCCGTACTGCCAAAAATAAGGGAGTTAGCATTCGCTTTGGTGGCTATGAACTTTTGGCAGACTTCTCCGATTTAATGAAAAAAACAGAAGATCGCAAAAGCATTCACCTTAGAGGCATTGATTACTACCGCAAACTCTTAGACAATTATCCCCAACACTCTTTCATTACTTTGGCTAGTCTCAATTTGAAAGAAAGACTTACCGAACTAGAAAGTCAAAGGAAAAAAGCTCAAAATAACCTTGCTAAATTTGGTGATAATGTTAAACCGAGCAAAATTGATAATACAAAAAAAGAAATCGAACGTCTCAGTGACGAGATTGCCTTTCTTCAAGAGCATTTATCCCAAGGTAAAGATACCGTTCCTCTTTCAGGAACATTATCTCTTGAATTCGGTAAAACATCCGAAAATGTCTATGCTGGTATGGATGACGAATTTCGCCGTTATCAAGCTGCTATCTATACTTGGTTTGCAACGGCTAACCATGCCTTTGAAAGAGGCAGTCACTGGCAAAATATGGGAGGTATTGAAAATGACCTCTCTGGCGGACTTTACAACTTCAAATCAAAATTCAAACCAGAAATTGAAGAATTTATTGGTGAATTTAATTTACCAGTCAGCCCGCTCTATAAATTAGCTAATATTGCCTATACCATACGTAAAAAACGAAGGAGCAAGCATTAA","10.00","11.39","46628","MYTYKIGISKEEHDNFIKNSSQTNLLQSSSWAKVKDEWENERIGFYQDSKLVASASILIRPLPLGMTMFYIPRGPVMNYQDKDLVNFVLTSLKKFAKRKRALFIKFDPFILLNHHQIDEEAINNPQAQTIIDTLKHLGCEWLGQTSDMGETIQPRFQANIYAEGFSEANLSKKIRQSIRTAKNKGVSIRFGGYELLADFSDLMKKTEDRKSIHLRGIDYYRKLLDNYPQHSFITLASLNLKERLTELESQRKKAQNNLAKFGDNVKPSKIDNTKKEIERLSDEIAFLQEHLSQGKDTVPLSGTLSLEFGKTSENVYAGMDDEFRRYQAAIYTWFATANHAFERGSHWQNMGGIENDLSGGLYNFKSKFKPEIEEFIGEFNLPVSPLYKLANIAYTIRKKRRSKH","676568","For other 'mur' genes see SMu0549 (murF); SMu0653 (murN);SMu0883 (murB); SMu1529 (murE); SMu1566 (murI); SMu0498 (murD);SMu0499 (murG); SMu1577 (murC); SMu1304 (murC);SMu1386 (murA) and SMu1429 (murZ).","beta-lactam resistance factor murM; Serine / alanine adding enzyme","Cytoplasm","Several matches in gapped BLAST to beta-lactam resistance factor murM: residues 1-404 are 62% similar to the protein in S.thermophilus (gi|13324647|)and are 53% similar to the protein from S.pneumoniae (gi|11385672|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0509 (1e-120).","

InterPro
IPR003447
Family

Methicillin resistance protein
PF02388	$\"[8-398]T$	FemAB
PS51191	$\"[1-394]T$	FEMABX

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[11-163]T$ $\"[168-368]T$	G3DSA:3.40.630.30

","BeTs to 3 clades of COG1196COG name: Chromosome segregation ATPasesFunctional Class: DThe phylogenetic pattern of COG1196 is am-kYqvc-br---gpol---Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 232-308 are 51% similar to a (MURM FACTOR RESISTANCE BETA-LACTAM) protein domain (PD262041) which is seen in Q9EZQ0_STRPN.Residues 309-403 are 60% similar to a (RESISTANCE FEMA FACTOR METHICILLIN) protein domain (PD006172) which is seen in Q9L389_STRPN.Residues 8-164 are 25% similar to a (DOMAIN OF UNKNO N) protein domain (PD339361) which is seen in Q9XAK9_STRCO.Residues 13-231 are 51% similar to a (RESISTANCE FACTOR FEMA METHICILLIN) protein domain (PD007011) which is seen in Q9K307_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 09:21:36 2002","Thu Oct 24 09:21:36 2002","Thu Oct 24 09:21:36 2002","Mon Dec 17 09:15:19 2001","","Mon Dec 17 09:15:19 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0654 is paralogously related (blast p-value < 1e-3) to SMu0653, a predicted beta-lactam resistance factor MurN;alanine addingenzyme;peptidoglycan branched peptide synthesis protein.","Wed Jan 23 16:33:16 2002","","No significant hits to the NCBI PDB database.","SMU.717c","","Residues 8 to 398 (E-value = 1.2e-15) place SMu0654 in the FemAB family which is described as FemAB family (PF02388)","Mon Dec 17 09:15:19 2001","","","","Filipe,S.R., Severina,E. and Tomasz,A.Distribution of the mosaic structured murM genes among naturalpopulations of Streptococcus pneumoniaeJ. Bacteriol. 182 (23), 6798-6805 (2000)Pubmed:11073926Smith,A.M. and Klugman,K.P.Alterations in MurM, a Cell Wall Muropeptide Branching Enzyme,Increase High-Level Penicillin and Cephalosporin Resistance inStreptococcus pneumoniaeAntimicrob. Agents Chemother. 45 (8), 2393-2396 (2001)PubMed: 11451707Webera,B., Ehlertb,K., Diehla,A., Reichmanna,P., Labischinskib,H.and Hakenbecka,R.The fib locus in streptococcus pneumoniae is required forpeptidoglycan crosslinking and PBP-mediated beta-lactam resistanceFEMS Microbiol. Lett. 188 (1), 81-85 (2000)PubMed: 10867238","","Mon Dec 17 09:21:29 2001","1","","","SMU.717c","288" "SMu0655","678586","677777","810","ATGTCAATTAAATTGGTTGCTGTCGATATTGACGGCACATTACTTAATAGTAAGCGTGAAGTAACACCTGAAGTTTACACTGCTATCCAAGATGCTAAAAAAGCCGGCGTCAAGGTCGTTATTGCAACAGGCCGCCCCATTGCTGGTGTAACCGATTTACTAGAAAAATTAAATCTCAAGGATCAAGGAGATTACGTGATTACTTTTAACGGTGCTTTAGTACAAGATACCGCAACTGGTGAAGACTTGATTAAAGAAACGTTAACTTATGATGATTATTTAGATATTGAATTGCTCAGTCGCAAATTAGGTGTGCACATGCATGCTATCTCTAAAGAAGGTATTTACACTGCCAATCGTGATATCGGCAAATACACTGTCCATGAAGCAAGTTTGGTTAACATGCCAGTCTATTATCGTACTCCTGAAGAAATGGTTGGCAAAGAGATTGTGAAAATAATGATGATTGACGAACCTGAAATGTTAGATGCTGCTATTGCTCAACTGCCAGCCAGCCTTTATGAACACTACACAGTTGTCAAATCAAGACCTTTTTATTTAGAAATCATGAATAAAAAAGTCAGCAAAGGCACTGCTATCGTTCATTTAGCAGAAAAGTTAGGACTTAGCAGAGATGAGACAATGGCTATTGGTGATGAGGAAAATGATCGTGCTATGCTAGAAGCTGTTGGAAGCCCTGTTGTGATGGAAAATGGTATTCCTGAACTCAAAAAAATGGCTAAGTACATCACCAAATCAAACGACAACAGTGGGGTCGCTTATGCAATTAAAAAGTGGGTATTAAACTAA","5.20","-6.78","29798","MSIKLVAVDIDGTLLNSKREVTPEVYTAIQDAKKAGVKVVIATGRPIAGVTDLLEKLNLKDQGDYVITFNGALVQDTATGEDLIKETLTYDDYLDIELLSRKLGVHMHAISKEGIYTANRDIGKYTVHEASLVNMPVYYRTPEEMVGKEIVKIMMIDEPEMLDAAIAQLPASLYEHYTVVKSRPFYLEIMNKKVSKGTAIVHLAEKLGLSRDETMAIGDEENDRAMLEAVGSPVVMENGIPELKKMAKYITKSNDNSGVAYAIKKWVLN","677782","","hydrolase, haloacid dehalogenase-like family","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins: residues 1-268 are 76% similar to the protein in S.pneumoniae (gi15903213).Residues 1-269 are 71% similar to the protein in S.pyogenes (gi15674695).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0511 (1e-121).","

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[5-263]T$	Cof-subfamily
PS01228	$\"[5-16]T$	COF_1

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[5-236]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[6-263]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[2-267]T$	G3DSA:3.40.50.1000
PTHR21485	$\"[203-254]T$	PTHR21485
PTHR21485:SF10	$\"[203-254]T$	PTHR21485:SF10
SSF56784	$\"[1-268]T$	SSF56784

","BeTs to 12 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","***** IPB000150 (Cof protein) with a combined E-value of 6.9e-27. IPB000150A 2-16 IPB000150B 36-45 IPB000150C 215-247","Residues 3-86 are 29% similar to a (PROTEOME COMPLETE) protein domain (PD201280) which is seen in O83314_TREPA.Residues 4-228 are 27% similar to a (RNPA-LICA R4 ORF) protein domain (PD107065) which is seen in YRR4_MYCCA.Residues 3-45 are 65% similar to a (PROTEOME COMPLETE SIPU BH0497) protein domain (PD306139) which is seen in Q9CGM1_LACLA.Residues 46-187 are 57% similar to a (PROTEOME COMPLETE YKIF IBPA-GYRB) protein domain (PD034656) which is seen in Q9CGM1_LACLA.Residues 4-45 are 50% similar to a (COMPLETE PROTEOME BU028 PLDB-METR) protein domain (PD388374) which is seen in Q9KS95_VIBCH.Residues 193-247 are 70% similar to a (PROTEOME COMPLETE HYDROLASE ATPASE) protein domain (PD001342) which is seen in Q9CGM1_LACLA.Residues 4-115 are 28% similar to a (PROTEOME COMPLETE MG265 VCA0243) protein domain (PD002063) which is seen in Q9CLI7_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 14:04:56 2002","Thu Sep 7 15:59:09 2006","Thu Sep 7 15:54:50 2006","Mon Dec 17 09:25:23 2001","Mon Dec 17 09:25:23 2001","Mon Dec 17 09:25:23 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0655 is paralogously related (blast p-value < 1e-3) to SMu0675, SMu0388, SMu1666, SMu0461, SMu0367, SMu0442, SMu1012, and SMu0674,all predicted conserved hypothetical proteins. ","Thu Jan 17 14:04:56 2002","","No significant hits to the NCBI PDB database.","SMU.718c","","Residues 3 to 240 (E-value = 1.2e-05) place SMu0655 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Mon Dec 17 09:25:23 2001","24379186","","","","","","1","","","SMU.718c","289" "SMu0656","680138","678834","1305","ATGAAAGAAAAAGTATTCCGAGATCCTGTTCATAATTATATACCTGTTGAAGATGAGCTCATTTATGATCTTATCAATAGCAAAGAATTCCAGCGACTGCGTCGCATTAAACAGTTAGGTTCATCTAGTTTTACCTTTCATGGTGCTGAACACAGCCGTTTTTCACACTGTCTTGGTGTTTATTATCTTGCCAGACGTGTTACCAATATTTTTGATAAAAAATACTCAGACATTTGGAATAGTAACGAATCTCTCTTAACCATGACCGCAGCTCTTTTGCATGATATTGGTCATGGGGCCTATTCTCATACTTTTGAGAGGCTGTTTGACACTAATCACGAAACCATTACTCAGCAGATTATTTTAAGTCCTGAAACAGAAATCAATACGATTTTAAGGCGTGTCTCACCAGATTTTCCTGACAAGGTCGCTAGTGTTATCAATCATACCTATTCTAACAAACAGGTTGAACAGCTCATTTCCAGCCAAATTGATGTTGATCGCATGGATTATCTCCTGCGAGATTCTTACTTTACTGGTGCTAGCTACGGTGAATTTGATTTAACACGCGTCTTACGCGTCATTCGTCCAATTGAAAATGGTATTGCTTTTTCAAGAGATGGCATGCATGCTGTAGAAGATTATATTATCAGTCGCTATCAAATGTACATGCAGGTTTATTTTCATCCAGCTAGCCGTGCTATGGAAGTTCTCTTGCAAAATCTACTCAAACGTGCAAAATACCTTTATCCCAAAGAAAAAGAATTTTTCACTGTTACATCACCTCATTTAATCCCTTTTTTTGAAAATAGGGTTACCCTAGAAGACTATCTTAGTCTGGATGACGGTGTCATGAATACCTATTTTCAAACTTGGATGCAAAGTGCAGACAAAATCTTATCTGACCTCGCTAGCCGTTTTATCAATCGCAAAGTCTTCAAATCAATCACTTTTGATGAAAAAGACCTCTCAAATTTAGAAAAACTAAGAAAAATTGTTAAAGACCTTGGTTTTGATCCAACATATTATACTGCTCTTCACCTTAATTTTGACCTTCCTTATGATGTCTACAAGCCAGATGTTCAAAATCCCCGCACTCAAATTGAAATGTTGCAAGAAGATGGCTCCATTGCCGAGCTGTCTACACTATCACCTCTCGTTCATACCTTATCTGGTACTACGCATGGCGATCGTCGCTTCTACTTTCCCAAGGAGATGCTTATCAAAGATGGTCTTTTTGTCGAAGCTAAAGAAAAGTTTTCTCACTATATCAAAAATAAGCATTTTTACAATCTCAGAGAGTGA","6.80","-1.92","51040","MKEKVFRDPVHNYIPVEDELIYDLINSKEFQRLRRIKQLGSSSFTFHGAEHSRFSHCLGVYYLARRVTNIFDKKYSDIWNSNESLLTMTAALLHDIGHGAYSHTFERLFDTNHETITQQIILSPETEINTILRRVSPDFPDKVASVINHTYSNKQVEQLISSQIDVDRMDYLLRDSYFTGASYGEFDLTRVLRVIRPIENGIAFSRDGMHAVEDYIISRYQMYMQVYFHPASRAMEVLLQNLLKRAKYLYPKEKEFFTVTSPHLIPFFENRVTLEDYLSLDDGVMNTYFQTWMQSADKILSDLASRFINRKVFKSITFDEKDLSNLEKLRKIVKDLGFDPTYYTALHLNFDLPYDVYKPDVQNPRTQIEMLQEDGSIAELSTLSPLVHTLSGTTHGDRRFYFPKEMLIKDGLFVEAKEKFSHYIKNKHFYNLRE","678839","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins: residues 1-429 are 73% similar to the protein in S.pneumoniae (gi|15903212|).Residues 1-430 are 72% similar to the protein from S.pyogenes (gi|15674697|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0512 (0.0).","

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[49-181]T$	HDc

InterPro
IPR006674
Domain

Metal-dependent phosphohydrolase, HD region, subdomain
PF01966	$\"[53-175]T$	HD

InterPro
IPR008983
Family

TNF-like
SSF49842	$\"[199-280]T$	TNF_like

noIPR
unintegrated

unintegrated
PTHR11373	$\"[2-340]T$	PTHR11373
PTHR11373:SF4	$\"[2-340]T$	PTHR11373:SF4
SSF109604	$\"[3-214]T$	SSF109604
SSF52374	$\"[300-348]T$	SSF52374

","BeTs to 8 clades of COG1078COG name: HD superfamily phosphohydrolasesFunctional Class: RThe phylogenetic pattern of COG1078 is amtk-qv--B----gp-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 56-109 are 50% similar to a (TRIPHOSPHOHYDROLASE COMPLETE PROTEOME) protein domain (PD006222) which is seen in Q9V1T1_PYRAB.Residues 4-54 are 72% similar to a (COMPLETE PROTEOME MG461 CHROMOSOME) protein domain (PD005052) which is seen in YWFO_BACSU.Residues 56-245 are 36% similar to a (PROTEOME COMPLETE BH1811 GTP-BINDING) protein domain (PD131532) which is seen in O67745_AQUAE.Residues 55-97 are 55% similar to a (PROTEOME COMPLETE YKIG 3'REGION) protein domain (PD405631) which is seen in Q9CGM0_LACLA.Residues 202-419 are 43% similar to a (PROTEOME COMPLETE 3'REGION BH3818) protein domain (PD131537) which is seen in YWFO_BACSU.Residues 202-390 are 60% similar to a (PROTEOME COMPLETE YKIG UU598) protein domain (PD312726) which is seen in Q9CGM0_LACLA.Residues 167-246 are 34% similar to a (CHROMOSOME 5 PROTEOME INDUCTION) protein domain (PD131529) which is seen in Q9X1N3_THEMA.Residues 158-243 are 36% similar to a (PROTEOME COMPLETE VNG0189C) protein domain (PD321384) which is seen in Q9HSK2_HALN1.Residues 156-243 are 30% similar to a (PROTEOME COMPLETE APE1281) protein domain (PD325418) which is seen in Q9YCH6_AERPE.Residues 98-156 are 76% similar to a (PROTEOME COMPLETE YKIG) protein domain (PD385181) which is seen in Q9CGM0_LACLA.Residues 98-199 are 57% similar to a (PROTEOME COMPLETE MG461 C04027) protein domain (PD375870) which is seen in Q9K6B1_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 23 16:55:08 2002","Mon Dec 17 09:28:51 2001","Wed Jan 23 16:55:08 2002","Mon Dec 17 09:28:51 2001","","Wed Jan 23 16:55:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0656 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 23 16:55:08 2002","","No significant hits to the NCBI PDB database.","SMU.719c","","Residues 53 to 175 (E-value = 2.4e-11) place SMu0656 in the HD family which is described as HD domain (PF01966)","Mon Dec 17 09:28:51 2001","24379187","","","","","","1","","","SMU.719c","" "SMu0657","680250","681128","879","ATGACAAATCGTTTAATATTAAATACCATTCAGTTACTTTTGATCAGTCTGATTACTTGGATAATGGGAACTATTTTATTACATACACGACAGCATCAAATTAATTTAAAAGAGAAATTTTTAACAGGGTTTTGGATCGGTTATGTGACAGATCTCTTGGATACTTTGGGAATTGGTACTTTTGCGACGACGACAACACTTTTTAAAGCGACAAAATTAGTTGAAGATGATCGTAAAATACCTGCCACCATGTCAACTGCCCATGTTGTTCCTGTTTTGGTTGAGGCACTTTGTTTTGTGACTATTGTCAAGGTGGACATTACTACTCTGGTTTGTATGGCAGCAGCCTCTTTTACGGGAGCCTTTGTTGGAACACGGATAACCAAAAATTGGAATACTCAACAGGTTCAACGTGTTTTGGGAATTTTGCTCATTATTGCAGCTTTGGTCATGGTTTACCGCATGCTGACCAATCCTGGAGCAGGCATTTCCTCTCAGATTCGTGGTCTAAAAGGCATTTGGCTTTTAGTTGGTATTATTTTTGATTTTATTATTGGCATGTTAATGACTATGGGATTGGGTAATTATGCGCCAGAATTGATTTTCTTTTCATTGATGGGCATCAATCCTTCCATTGCTTTGCCCGTTATGATGTTGGATGCAGCCATGATTTTAACAGCCAGTTCAATAGCATTTATTAAATCTGACCGTGTTCATTGGCCGGGGACCTTTGGCATCATTATTGGTGGTGTCCTTGGCGTTTTAACAGCAGCCTTCTTTCTCAGTAATTTAGACATTAACCATCTCAAGATTTTAGTTGTCTTTATTGCCTTCTTTACGGGTGCAACATTGTTGCGTTCTTCTATTATAAGAAGATAG","10.60","9.09","31990","MTNRLILNTIQLLLISLITWIMGTILLHTRQHQINLKEKFLTGFWIGYVTDLLDTLGIGTFATTTTLFKATKLVEDDRKIPATMSTAHVVPVLVEALCFVTIVKVDITTLVCMAAASFTGAFVGTRITKNWNTQQVQRVLGILLIIAALVMVYRMLTNPGAGISSQIRGLKGIWLLVGIIFDFIIGMLMTMGLGNYAPELIFFSLMGINPSIALPVMMLDAAMILTASSIAFIKSDRVHWPGTFGIIIGGVLGVLTAAFFLSNLDINHLKILVVFIAFFTGATLLRSSIIRR","681127","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical proteins: residues 5-288 are 53% similar to the protein in S.pyogenes (gi|15675675|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1731 (4e-90).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-23]?$	signal-peptide
tmhmm	$\"[9-29]?$ $\"[48-68]?$ $\"[89-123]?$ $\"[137-157]?$ $\"[172-192]?$ $\"[211-233]?$ $\"[243-263]?$ $\"[269-289]?$	transmembrane_regions

InterPro
IPR011038
Domain

Calycin-like
SSF50814	$\"[1-129]T$	Calycin

InterPro
IPR015231
Family

Domain of unknown function DUF1934
PF09148	$\"[1-127]T$	DUF1934

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-129 are 27% similar to a (PROTEOME COMPLETE) protein domain (PD397355) which is seen in Q9CGL9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 07:53:52 2002","Mon Dec 17 09:34:57 2001","Thu Jan 24 07:53:52 2002","Mon Dec 17 09:34:57 2001","","Mon Dec 17 09:34:57 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0658 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 07:53:52 2002","","No significant hits to the NCBI PDB database.","SMU.721","","No significant hits to the Pfam 11.0 database","Mon Dec 17 09:34:57 2001","24379189","","","","","","1","","","SMU.721","907" "SMu0659","681658","681837","180","ATGAGTGGTTTTACCATGACTCTTAGCTATTGTTTTTCTGTCGAATCATTCTATAAGAATGCCATTTATAATCCAATTTCTGGGAAAATCTTAAAAAGCCAAGCATCGCTTTTTGAAAGGGGAACAGGCTTCTTCAAAATGAGGTATTTTATATTGAAAAGGCCTTTATTTATGGTATAA","10.80","5.93","6877","MSGFTMTLSYCFSVESFYKNAIYNPISGKILKSQASLFERGTGFFKMRYFILKRPLFMV","681836","","hypothetical protein","Cytoplasm, Extracellular","No hits in gapped BLAST found.SMu0659 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 07:54:51 2002","Mon Dec 17 09:36:12 2001","Thu Jan 24 07:54:51 2002","Mon Dec 17 09:36:12 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0659 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 07:54:51 2002","","No significant hits to the NCBI PDB database.","SMU.722","","No significant hits to the Pfam 11.0 database","Mon Dec 17 09:36:12 2001","24379190","","","","","","1","","","SMU.722","" "SMu0660","681984","684665","2682","TTGTTCAAAAAACAAAAAAGGGACAGTTTTTACGTCCAAGATGAAAAAACTGTCCTATCTGGCCTAGAATCTTCTAAGAAGGGATTGACCAGTACTCAAGCTAAACAGCGCTTAGCTGATTATGGCTACAATGAATTGGAAGAAGATGAAAAACGTACTATTCTTGCCAAATTCATTGATCAATTTAAGGATTTGATGATTATCATTTTGCTTGTTGCCGCAGCGCTTTCGGTTATCACTGAAGGAATGGGGGGGCTAACGGATGCCATCATTATTCTAGTTGTTGTTGTTTTAAATGCAGCCTTCGGTGTCTATCAGGAAGGACAGGCAGAAGCAGCCATTGAGGCCTTAAAATCTATGTCTAGTCCACATGCACGTGTTCGGCGTGATGGCCATGTTACTGAAATTGATTCCAAAGAATTAGTACCAGGTGATGTCGTTCTTCTTGAAGCTGGTGATGTGGTTCCGGCAGATATGCGTCTTTTGGAAGCAGCTTCGTTGAAAATTGAAGAGGCAGCCTTAACAGGTGAGTCTGTGCCAGTTGAAAAAAGTGTAACTGTTGCAATTGCATCAGATGCTGGTATTGGTGATCGTTTGAATATGGCCTATCAAAATTCAAATGTTACTTATGGTCGTGGTATGGGGGTTGTGACCAATACTGGTATGTACACAGAAGTCGGCCATATTGCTGGCATGTTAGCTAATGCAGATGAAACAGATACGCCATTAAAACAGAGTTTAGATAATCTATCCAAGGTATTGACATATGTTATCATTATTATTGCGATTATTACTTGCCTAGTTGGTATCTTTGTTCGTCATGAAGAGCCTCTTGAAGGTTTGATGGTTGCTGTTGCTTTGGCTGTTGCTGCCATTCCTGAAGGACTTCCAGCCATTGTAACAGTTGTCCTTTCACTTGGTACGAAAACACTTGCCAAACGTCAGTCCATTGTTCGTAAATTACCAGCTGTAGAAACGCTTGGTTCTACTGAAATCATTGCTTCAGATAAAACCGGTACGCTGACCATGAATCAAATGACTGTTGAGAAAGTCTATTATAATGGTAGATTAGTTGATGCTAATGATGACATTGACGTTAATAATATGGCTCTTCGCGTTATGAACTTTGCTAATGACAGTAAGGTTGATGCCAATGGTAAATTAATTGGTGATCCTACTGAAACAGCTCTTGTTCAATATGGTTTTGATCATAATTTCGATATTCGCGAAGTACTTAAAGCTGAACTACGTGTCGCTGAATTGCCATTTGATTCTGATCGTAAGCTCATGTCAACGATTCATAAACTTGATGGTGAGAAATATCTGATTGCTGTCAAGGGAGCACCGGATCAATTGCTCAAACGTATAACGCAAATTGAGATAGATGGTAGTATTCGTCCAATCACTGAGGACGATAAAAAAGCCATTCTTGATATGAACAAGTCGCTTGCCAAACAGGCGCTTCGTGTTCTCATGATAGCTTACAAATACGAGTCTGAAATTCCAAAATTAGAAACGGCAGTCGTTGAAAATGATTTGATTTTTGCTGGTCTTGTGGGGATGATTGACCCAGAGCGTCCAGAAGCGGCTGAAGCTGTTCATGTGGCTAAAGAAGCCGGCATTCGTCCAATCATGATTACAGGTGATCATCAAGATACTGCTGAAGCCATTGCCAAACGTTTGGGAATTATTGATGATGATGGAATTGATCATGTCTTCACTGGTGCTGAACTCAATGAACTTTCTGATGAAGAATTCCAAAAAGTTTTCAAACAGTATTCGGTTTATGCGCGCGTGTCACCGGAGCATAAGGTTCGGATTGTCAAGGCTTGGCAAAATGATGGTAAGATTGTTGCTATGACAGGTGATGGGGTTAATGATGCGCCATCTCTTAAAACGGCTGATATTGGTATTGGTATGGGAATCACAGGTACTGAAGTATCTAAGGGTGCTTCTGATATGGTGCTTGCCGATGATAACTTTGCAACCATTATTGTTGCGGTTGAAGAAGGACGTAAGGTCTTCTCCAATATCCAAAAATCAATTCAGTACCTGCTATCTGCCAACATGGCTGAAGTTTTCACCATCTTCTTTGCAACTCTCTTTGGTTGGGATGTGCTTCAACCCGTTCATCTGCTCTGGATTAATTTGGTGACAGATACTCTGCCAGCCATCGCTCTTGGTGTTGAACCGGCTGAGCCTGGTGTGATGACCCATAAACCTCGTGGACGCAAGTCAAGCTTCTTCTCAGGTGGTGTTATGGGAGCCATTATCTATCAAGGTATTCTACAAACTCTTCTTGTACTTGGCGTTTACGGCTGGGCAGTTTTCTTTCCTGAACATGCGACACGTACAGAAATTCATGCAGATGCTCTTACCATGGCCTTTGCAACACTTGGTTTGATTCAATTGGTACATGCTTATAATGTCAAATCGGTTTATCAGTCCATTTTTAAGGTTGGTTTCTTTAAAAACAAAACATTTAACTGGGCTTTGCCGACTGCTTTGATTATTATGCTTGCTACCATTGTCATTCCAGGATTTAATAGATTCTTCCATGTGTCTCACTTGTCGGTGACCCAATGGTGTGTTGTTGTGGGAGGTAGTTTGGCCATGTTTGTTATTGTTGAAATTGTAAAAGCCATTCAACGGGTACTTGGTCAAGATCAAAAAGCGATTTAA","5.10","-22.90","97275","MFKKQKRDSFYVQDEKTVLSGLESSKKGLTSTQAKQRLADYGYNELEEDEKRTILAKFIDQFKDLMIIILLVAAALSVITEGMGGLTDAIIILVVVVLNAAFGVYQEGQAEAAIEALKSMSSPHARVRRDGHVTEIDSKELVPGDVVLLEAGDVVPADMRLLEAASLKIEEAALTGESVPVEKSVTVAIASDAGIGDRLNMAYQNSNVTYGRGMGVVTNTGMYTEVGHIAGMLANADETDTPLKQSLDNLSKVLTYVIIIIAIITCLVGIFVRHEEPLEGLMVAVALAVAAIPEGLPAIVTVVLSLGTKTLAKRQSIVRKLPAVETLGSTEIIASDKTGTLTMNQMTVEKVYYNGRLVDANDDIDVNNMALRVMNFANDSKVDANGKLIGDPTETALVQYGFDHNFDIREVLKAELRVAELPFDSDRKLMSTIHKLDGEKYLIAVKGAPDQLLKRITQIEIDGSIRPITEDDKKAILDMNKSLAKQALRVLMIAYKYESEIPKLETAVVENDLIFAGLVGMIDPERPEAAEAVHVAKEAGIRPIMITGDHQDTAEAIAKRLGIIDDDGIDHVFTGAELNELSDEEFQKVFKQYSVYARVSPEHKVRIVKAWQNDGKIVAMTGDGVNDAPSLKTADIGIGMGITGTEVSKGASDMVLADDNFATIIVAVEEGRKVFSNIQKSIQYLLSANMAEVFTIFFATLFGWDVLQPVHLLWINLVTDTLPAIALGVEPAEPGVMTHKPRGRKSSFFSGGVMGAIIYQGILQTLLVLGVYGWAVFFPEHATRTEIHADALTMAFATLGLIQLVHAYNVKSVYQSIFKVGFFKNKTFNWALPTALIIMLATIVIPGFNRFFHVSHLSVTQWCVVVGGSLAMFVIVEIVKAIQRVLGQDQKAI","684664","","calcium-transporting ATPase","Membrane, Cytoplasm","Several matches in gapped BLAST to calcium-transporting ATPase: residues 3-893 are 76% similar to the enzyme in S.pyogenes (gi15674699)and are 67% similar to the protein from S.pneumoniae(gi15903453).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0514 (0.0).","

InterPro
IPR000695
Family

H+ transporting ATPase, proton pump
PR00120	$\"[476-494]T$ $\"[593-609]T$ $\"[621-637]T$ $\"[653-678]T$	HATPASE

InterPro
IPR001757
Family

ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119	$\"[170-184]T$ $\"[334-348]T$ $\"[517-528]T$ $\"[539-549]T$ $\"[621-640]T$ $\"[645-657]T$	CATATPASE
PTHR11939	$\"[24-747]T$	CATION-TRANSPORTING ATPASE
TIGR01494	$\"[91-183]T$ $\"[241-352]T$ $\"[595-704]T$	ATPase_P-type: ATPase, P-type (transporting
PS00154	$\"[336-342]?$	ATPASE_E1_E2

InterPro
IPR004014
Domain

ATPase, P-type cation-transporter, N-terminal
PF00690	$\"[4-82]T$	Cation_ATPase_N

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[330-644]T$	Hydrolase

InterPro
IPR006068
Domain

ATPase, P-type cation-transporter, C-terminal
PF00689	$\"[739-886]T$	Cation_ATPase_C

InterPro
IPR008250
Domain

E1-E2 ATPase-associated region
PF00122	$\"[91-326]T$	E1-E2_ATPase

InterPro
IPR013248
Family

Shr3 amino acid permease chaperone
SM00786	$\"[211-388]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:1.20.1110.10	$\"[595-889]T$	no description
G3DSA:2.70.150.10	$\"[7-214]T$	no description
G3DSA:3.40.1110.10	$\"[344-524]T$	no description
PTHR11939:SF85	$\"[24-747]T$	CATION-TRANSPORTING ATPASE, E1-E2 FAMILY
tmhmm	$\"[67-87]?$ $\"[253-271]?$ $\"[281-301]?$ $\"[684-704]?$ $\"[748-768]?$ $\"[787-807]?$ $\"[828-848]?$ $\"[862-882]?$	transmembrane_regions

","BeTs to 9 clades of COG0474COG name: Cation transport ATPasesFunctional Class: PThe phylogenetic pattern of COG0474 is -mT-Yq-CebR---gp-----Number of proteins in this genome belonging to this COG is 2","***** IPB001757 (E1-E2 ATPases) with a combined E-value of 1.7e-26. IPB001757A 333-344 IPB001757B 612-641 IPB001757B 538-567","Residues 457-586 are 33% similar to a (F ATP-BINDING PHOSPHORYLATION MAGNESIUM) protein domain (PD266100) which is seen in CTPF_MYCTU.Residues 254-351 are 51% similar to a (ATPASE HYDROLASE TRANSMEMBRANE ATP-BINDING) protein domain (PD000466) which is seen in ATA1_SYNY3.Residues 794-880 are 28% similar to a (ATPASE CALCIUM HYDROLASE TRANSMEMBRANE) protein domain (PD000388) which is seen in Q9D922_MOUSE.Residues 417-526 are 29% similar to a (ATPASE HYDROLASE TRANSMEMBRANE) protein domain (PD336512) which is seen in ATMA_SALTY.Residues 590-668 are 36% similar to a (TRAX) protein domain (PD162139) which is seen in Q50124_MYCLE.Residues 541-632 are 35% similar to a (ATPASE-LIKE CA2-TRANSPORTING) protein domain (PD241169) which is seen in Q9LVV1_ARATH.Residues 388-742 are 21% similar to a (CG3701) protein domain (PD309831) which is seen in Q9W248_DROME.Residues 719-884 are 25% similar to a (TRANSPORT ATPASE SODIUM PHOSPHORYLATION) protein domain (PD186454) which is seen in ATC3_SCHPO.Residues 632-720 are 33% similar to a (MG2 ATP-BINDING TRANSMEMBRANE) protein domain (PD339717) which is seen in ATMA_SALTY.Residues 540-631 are 61% similar to a (ATPASE HYDROLASE TRANSMEMBRANE PHOSPHORYLATION) protein domain (PD000121) which is seen in Q9PQM7_UREPA.Residues 632-754 are 29% similar to a (ATPASE INTEGRAL CATION-TRANSPORTING) protein domain (PD189829) which is seen in Q9KXM5_STRCO.Residues 632-720 are 60% similar to a (ATPASE HYDROLASE CALCIUM TRANSMEMBRANE PHOSPHORYLATION) protein domain (PD000140) which is seen in Q42883_LYCES.Residues 369-455 are 44% similar to a (ATPASE HYDROLASE ALPHA PHOSPHORYLATION TRANSMEMBRANE) protein domain (PD000320) which is seen in Q9CFU9_LACLA.Residues 88-217 are 48% similar to a (ATPASE HYDROLASE TRANSMEMBRANE ATP-BINDING) protein domain (PD000132) which is seen in Q59999_SYNY3.Residues 640-720 are 45% similar to a (ATPASE HYDROLASE ATP-BINDING TRANSMEMBRANE) protein domain (PD274998) which is seen in Q9P872_CANAL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 22 11:09:31 2002","Mon Dec 17 09:38:16 2001","Thu Jul 27 10:34:51 2006","Mon Dec 17 09:38:16 2001","Mon Dec 17 09:38:16 2001","Mon Dec 17 09:38:16 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0660 is paralogously related (blast p-value < 1e-3) to SMu1421 and SMu0386,both predicted copper-transporting ATPase, and SMu1867,a predicted cadmium-efflux ATPase, E1-E2 (heavy metal-transporting ATPase).","Tue Jan 22 11:07:07 2002","Thu Jul 27 10:34:51 2006","pdb1EULA Chain A, Crystal Structure Of Calcium Atpase With Tw... 453 3e-128","SMU.723","","Residues 4 to 82 (E-value = 2.5e-23) place SMu0660 in the Cation_ATPase_N family which is described as Cation transporter/ATPase, N-terminus (PF00690)Residues 91 to 326 (E-value = 1.3e-99) place SMu0660 in the E1-E2_ATPase family which is described as E1-E2 ATPase (PF00122)Residues 330 to 644 (E-value = 6.4e-18) place SMu0660 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)Residues 739 to 886 (E-value = 5.9e-22) place SMu0660 in the Cation_ATPase_C family which is described as Cation transporting ATPase, C-terminus (PF00689)","Thu Jul 27 10:34:51 2006","24379191","","Vats,N. and Lee,S.F.Characterization of a copper-transport operon, copYAZ, fromStreptococcus mutansMicrobiology 147 (Pt 3), 653-662 (2001)PubMed: 11238972PUBMED: 11238972","Kanamaru,K., Kashiwagi,S. and Mizuno,T.The cyanobacterium, Synechococcus sp. PCC7942, possesses twodistinct genes encoding cation-transporting P-type ATPasesFEBS Lett. 330 (1), 99-104 (1993)PubMed: 8370468","Tue Jan 22 11:09:58 2002","Mon Dec 17 09:46:00 2001","1","","","SMU.723","65" "SMu0661","684778","685518","741","ATGACTCAGATTTTTGCTCATAGAGGAAGTAAAGTTGATTGTCCGGAAAATACACTTGCTGCTTTTAAAAAGGCGATTCAGGTGGGGTGTGATGGCATTGAGATAGATGTTCACCGAACAAAAGACAATCAACTTGTTGTTATTCATGATGAAGCAGTTGATCGAACCAGCAATGGCTCTGGATTGGTCAGACAACTGACATTAAAGCAAATAAGAATGCTTGATGCTGGTTCTTGGTTTCATCCAGCTTATTTTTGTGAGAAAATTCCAACCTTAGAAGAAGTTTTAAATTTTTTGGAAGAGTCTGGTTTTCAGGGAACTCTCAATCTAGAAATCAAAACCAATAGATATCCTTATCCTAAAATTGAAAAGCAAATTGCACAAACTATGCAGGCTAAAAAACGTTCTTTTTCGCATATTTATTCTAGTTTTAATCTTTTTAGTTTATATGTAATGAGAAAACATGATCCTAAGGCTGAGTTAGCTTATTTAATGAAATTTCATCCTTTTCATTTTTGGTTGGCACAACAGTTAAAATTTATTAAGACTGTCCATTCACACAGTTCTTTTTATGAAAATCAAGTGACTAAAAGAAAAAATAAAAAACCATTTCGGCTTTGGACGGTTAATAATGATGATGACATGAAAAAATTCTTTTTGTCTGGGATAGAAGGAATTATAACAGATAAACCAGAAGAAGCTGTTAAACTCAGAAAATCATTACAAACTAAAAAAGAATGA","10.20","12.27","28674","MTQIFAHRGSKVDCPENTLAAFKKAIQVGCDGIEIDVHRTKDNQLVVIHDEAVDRTSNGSGLVRQLTLKQIRMLDAGSWFHPAYFCEKIPTLEEVLNFLEESGFQGTLNLEIKTNRYPYPKIEKQIAQTMQAKKRSFSHIYSSFNLFSLYVMRKHDPKAELAYLMKFHPFHFWLAQQLKFIKTVHSHSSFYENQVTKRKNKKPFRLWTVNNDDDMKKFFLSGIEGIITDKPEEAVKLRKSLQTKKE","685517","For other 'glp' genes see SMu0359 (glpF). From Genbank: [gi:585208]This enzyme hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols","glycerophosphodiester phosphodiesterase","Cytoplasm","Several matches in gapped BLAST to glycerophosphodiester phosphodiesterase: residues 1-240 are 37% similar to the enzyme in Listeria innocua (gi|16800398|). Residues 6-239 are 36% similar to the protein from Clostridium acetobutylicum (gi|15893721|).SMu0661 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004129
Family

Glycerophosphoryl diester phosphodiesterase
PTHR23344	$\"[1-168]T$	GDPD
PF03009	$\"[7-233]T$	GDPD

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.190	$\"[2-241]T$	G3DSA:3.20.20.190
SSF51695	$\"[1-239]T$	SSF51695

","BeTs to 7 clades of COG0584COG name: Glycerophosphoryl diester phosphodiesteraseFunctional Class: CThe phylogenetic pattern of COG0584 is ----Y-v-EBRh--GP-l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-113 are 59% similar to a (PHOSPHODIESTERASE COMPLETE PROTEOME GLYCEROPHOSPHORYL) protein domain (PD002136) which is seen in Q9CJD3_LACLA.Residues 7-103 are 36% similar to a (PHOSPHODIESTERASE PROTEOME COMPLETE) protein domain (PD088163) which is seen in Q9CIY9_LACLA.Residues 114-246 are 34% similar to a (PROTEOME COMPLETE YAGA) protein domain (PD397414) which is seen in Q9CJD3_LACLA.Residues 1-113 are 35% similar to a (PROTEOME COMPLETE DIESTER) protein domain (PD396167) which is seen in Q9RWX3_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 13:59:54 2002","Thu Jan 24 07:58:36 2002","Thu Oct 24 13:59:54 2002","Mon Dec 17 09:50:48 2001","","Mon Dec 17 09:50:48 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0661 is paralogously related (blast p-value < 1e-3) to SMu1256, a predicted conserved hypothetical protein.","Wed Mar 6 08:23:46 2002","","No significant hits to the NCBI PDB database.","SMU.724","","Residues 7 to 233 (E-value = 1.1e-43) place SMu0661 in the GDPD family which is described as Glycerophosphoryl diester phosphodiesterase family (PF03009)","Mon Dec 17 09:50:48 2001","24379192","","","Nilsson,R.P., Beijer,L. and Rutberg,B.The glpT and glpQ genes of the glycerol regulon in BacillussubtilisMicrobiology 140 (Pt 4), 723-730 (1994)PubMed: 8012593","","Mon Dec 17 09:55:41 2001","1","","","SMU.724","" "SMu0662","686740","685823","918","ATGACAATAGCCAAAAACTTCTTTAAAGCAATTTTCACTTACTTCTGCTACAATGAAGCTATGACTAAACTTGCAATTATGAGTGATTTGCATATTGATCTTAATCACTTTGGGACTTTAGAAATTGAAACGCTCAAACAGGTTCTGCACCAACAAAAGATTGACCATCTTCATCTGGCAGGAGATATTTCTAATCATTTTTACGATGTTACACTTCCTTTTATTGAAGAACTTGAAAAAGACGTCAAGGTAACCTATAATTTAGGAAACCATGATATGTTAGATTTAGATGAAGATGCCATTCAAGCTTCTGATTTTCAAGTTCACCAAATTGGATCGGCTTTTCTATTAGCTTTTCATGCTTGGTACGATTATTCCTTTTCCCATCAAGAACAAACAAAGATTAACAGCCTCAAAAAGACCTTTTGGTTTGATCGACGCCTGCAACGCCTCAAAGATGATCTGACAATTACTCAGGAGTCACTTATAAAACTGAATCAAATTCTACATTCTTTACCAAGCCAAAGACTTATTGTAGCCATGCATTTTGTTCCCCATCAAGAGTTCCTGTTGACTCATCCACGATTTGCACCTTTTAATGCTTTCTTAGGAAGCCAAAAATTTCATCAGCTTTTTGTTCAGCACCAAATTAAAGATGTTACCTTTGGCCATGCTCATAGAAGTTTTGGTGATATCAAACTAGACGGTGTTGTTTACCACTCAAGGCCTCTAGGCTATATCCGTGAATGGGATTTGACCATTAATTTTGTTAATCAGCATCCCCAATACAATCCTTCAGGTAGCTGGAATCTCAGTAAACGTTATAATACCGTTAGGTATTTAGAGGATTATCAAGCTTATAAAAGAAAATATTTAGCCAAAGAATTTTCCCATTCCATGACGATTTTTGACTGTTAA","7.10","0.96","36065","MTIAKNFFKAIFTYFCYNEAMTKLAIMSDLHIDLNHFGTLEIETLKQVLHQQKIDHLHLAGDISNHFYDVTLPFIEELEKDVKVTYNLGNHDMLDLDEDAIQASDFQVHQIGSAFLLAFHAWYDYSFSHQEQTKINSLKKTFWFDRRLQRLKDDLTITQESLIKLNQILHSLPSQRLIVAMHFVPHQEFLLTHPRFAPFNAFLGSQKFHQLFVQHQIKDVTFGHAHRSFGDIKLDGVVYHSRPLGYIREWDLTINFVNQHPQYNPSGSWNLSKRYNTVRYLEDYQAYKRKYLAKEFSHSMTIFDC","685828","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical and unknown proteins: residues 23-246 are 45% similar to an unknown in Lactococcus lactis subsp. lactis (gi|15672952|) and residues 23-250 are 29% similar to a conserved hypothetical in S.aureus (gi|15928015|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0515 (1e-109).","

InterPro
IPR004843
Domain

Metallophosphoesterase
PF00149	$\"[22-228]T$	Metallophos

noIPR
unintegrated

unintegrated
SSF56300	$\"[17-233]T$	SSF56300

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 53-227 are 46% similar to a (PROTEOME COMPLETE) protein domain (PD315200) which is seen in Q9CGX2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 14:59:06 2002","Mon Dec 17 10:23:25 2001","Tue Mar 19 14:59:06 2002","Mon Dec 17 10:23:25 2001","","Mon Dec 17 10:23:25 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0662 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 17 10:25:35 2001","","No significant hits to the NCBI PDB database.","SMU.725c","","Residues 22 to 228 (E-value = 2.5e-09) place SMu0662 in the Metallophos family which is described as Calcineurin-like phosphoesterase (PF00149)","Mon Dec 17 10:23:25 2001","24379193","","","","","","1","","","SMU.725c","290" "SMu0663","686922","687305","384","ATGAGGATTGGAGAGGTTTCTAAATTGACGAATGTCAGTATGAGATCGTTGCGCTATTATGAGGAAAAAGGATTAATCCATCCAGAAAGATTAGAGAACGGTTACCGTGATTATGATAAATTAACGCTAGAGCGAATTAAGACATTAAAATTATATTTTGATTTAGGATTAACAACAGCAGAAATGCAGCAGGTCATGGGTTGTGATCCCTTTGTTTTTCCATATAAGAACCTTATGTGTAAAGATGTTATTATGATTTATGAGGATAAGCTTAAAGAAGTTAGTCATCAAATTCAGATTTTACAACAGATTGAATCCCGCTTAAAAGAGCGATTGATGAAAATTTATCATTTAAAGGAGGATGGCATAAATGAAAGGTATTGA","8.10","1.62","15284","MRIGEVSKLTNVSMRSLRYYEEKGLIHPERLENGYRDYDKLTLERIKTLKLYFDLGLTTAEMQQVMGCDPFVFPYKNLMCKDVIMIYEDKLKEVSHQIQILQQIESRLKERLMKIYHLKEDGINERY","687304","","mercury resistance operon negative regulator","Cytoplasm","Several matches in gapped BLAST to transcriptional regulators: residues 1-50 are 60% similar to the protein in B.halodurans (gi15616019).Residues 2-110 are 34% similar to the protein from B.licheniformis (gi11071705).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2024 (2e-11).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PR00040	$\"[2-13]T$ $\"[13-26]T$ $\"[36-56]T$	HTHMERR
PF00376	$\"[2-38]T$	MerR
SM00422	$\"[1-69]T$	HTH_MERR
PS00552	$\"[4-26]T$	HTH_MERR_1
PS50937	$\"[1-68]T$	HTH_MERR_2

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[1-111]T$	Putativ_DNA_bind

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[1-112]T$	G3DSA:1.10.1660.10

","BeTs to 7 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 4.3e-22. IPB000551A 3-24 IPB000551B 25-66","Residues 5-38 are 70% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REGULATOR) protein domain (PD000861) which is seen in Q9K7A9_BACHD.Residues 1-119 are 27% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD292015) which is seen in Q9K674_BACHD.Residues 3-66 are 42% similar to a (PROTEOME DNA-BINDING REGULATION) protein domain (PD167972) which is seen in Q45666_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 15 08:56:32 2002","Tue Mar 6 15:16:40 2007","Tue Mar 6 15:16:40 2007","Mon Dec 17 10:29:54 2001","Mon Dec 17 10:29:54 2001","Mon Dec 17 10:29:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0663 is paralogously related (blast p-value < 1e-3) to SMu1630, SMu1174, SMu0328, SMu1868, SMu1918, SMu0144, and SMu0477, all possible transcriptional regulators. ","Tue Jan 15 08:56:32 2002","","No significant hits to the NCBI PDB database.","SMU.727","","Residues 2 to 38 (E-value = 2.9e-14) place SMu0663 in the MerR family which is described as MerR family regulatory protein (PF00376)","Mon Dec 17 10:29:54 2001","24379194","","","","","","1","","","SMU.727","" "SMu0664","687292","688176","885","ATGAAAGGTATTGAAATAGTGAATTATGGCGGACCGGAGGTTGCTAAGGTTCGAACATTTAGCAGTCCCGTTAGACGATCAGGAGAAGTGATGATTCAAGTAGTTGCCTCTTCAATTAATCCAGTAGACATAAAGTATATGACGCCGGAAACGATTCAGAAAATTCCTTCTTTCCCAGCAATTTTAGGTTGGGATATTGCTGGGATTATAATAGAAGCTGATAAGAATTCAAATTTTTCCGCTGGTGAGCGTGTGGTGGCTTTTCATCCACAAGGGAGCTGGCAGCAACTAGTTACTGCCTCTGAGAATCAGGTTGTAAAATTGCCTGATAATATTGATTTTATCAGTGGAGGCAGTATTCCTTTAGCCGCTTCAACGGCTTTGCAAGCTTTAAGAAGATTACGACTAGAGCCCGGCGAACGTTTACTTGTTACCGGAGCAGCTGGCAGTGTCGGCTATTACGCACTTCAATTTGCTCTGAAAATGGGAGTTAAAGCATCTGGCTTAGTAAGAAATAAAAATCAAAAAATGAGCATAAATTTATTAGACACAGAAATTTATACAAATGATGATCCTATTCCTGAATTTGATGCTGTCTTTGATACGGCAGGTGTACTAAATCGTATTGATGTCATCCACAAGGGTGGAAGACTCGTGACTGTCAGCGATGAACAGATTGATCCACAAGTACTAAAACATACCTCTTTTGCTGAACATAATTACGTTAGAGTAAACAAGGAAGACTTGGAAGAAATTGTCCATCTTGTTTCGGAAGCAAAGATAGAAACCAGAGTTGCAAAGATATATTCTTTTAATAATGTTCAGGAAGCTCTAGCACAGGCTATAAAGTCTGGAAATAATGGAAAAGTCATGCTCATTTTCTAG","6.40","-1.78","32175","MKGIEIVNYGGPEVAKVRTFSSPVRRSGEVMIQVVASSINPVDIKYMTPETIQKIPSFPAILGWDIAGIIIEADKNSNFSAGERVVAFHPQGSWQQLVTASENQVVKLPDNIDFISGGSIPLAASTALQALRRLRLEPGERLLVTGAAGSVGYYALQFALKMGVKASGLVRNKNQKMSINLLDTEIYTNDDPIPEFDAVFDTAGVLNRIDVIHKGGRLVTVSDEQIDPQVLKHTSFAEHNYVRVNKEDLEEIVHLVSEAKIETRVAKIYSFNNVQEALAQAIKSGNNGKVMLIF","688175","","oxidoreductase","Cytoplasm","Matches in gapped BLAST to oxidoreductase: residues 1-294 are 28% similar to the enzyme in Listeria innocua (gi|16799697|) and in Listeria monocytogenes (gi|16802655|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1544 (4e-04).","

InterPro
IPR002085
Family

Alcohol dehydrogenase superfamily, zinc-containing
PTHR11695	$\"[14-294]T$	ADH_Sf_Zn

InterPro
IPR011032
Domain

GroES-like
SSF50129	$\"[1-142]T$	GroES_like

InterPro
IPR013154
Domain

Alcohol dehydrogenase GroES-like
PF08240	$\"[27-108]T$	ADH_N

noIPR
unintegrated

unintegrated
G3DSA:3.90.180.10	$\"[1-174]T$	G3DSA:3.90.180.10
PTHR11695:SF34	$\"[14-294]T$	PTHR11695:SF34
SSF51735	$\"[112-260]T$	SSF51735

","BeTs to 3 clades of COG0604COG name: NADPH:quinone reductase and related Zn-dependent oxidoreductasesFunctional Class: C,RThe phylogenetic pattern of COG0604 is ----Yq--ebR----------Number of proteins in this genome belonging to this COG is 3","***** IPB002328 (Zinc-containing alcohol dehydrogenase) with a combined E-value of 1.5e-08. IPB002328A 14-45 IPB002328B 59-84 IPB002328D 105-152","Residues 2-70 are 37% similar to a (OXIDOREDUCTASE DEHYDROGENASE ZINC ALCOHOL NAD COMPLETE) protein domain (PD225307) which is seen in QOR_CAVPO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 08:47:51 2002","Fri Jan 18 08:39:53 2002","Fri Oct 11 15:15:43 2002","Mon Dec 17 10:34:22 2001","Mon Dec 17 10:34:22 2001","Mon Dec 17 10:34:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0664 is paralogously related (blast p-value < 1e-3) to SMu1005 and SMu0583,both predicted oxidoreductases.","Thu Jan 24 08:47:51 2002","","No significant hits to the NCBI PDB database.","SMU.728","","Residues 10 to 294 (E-value = 6.4e-33) place SMu0664 in the ADH_zinc_N family which is described as Zinc-binding dehydrogenase (PF00107)","Mon Dec 17 10:34:22 2001","24379195","","","","","","1","","","SMU.728","" "SMu0665","688445","688657","213","GTGAAAACACCAAAAGGTAAATATGCTTGGACAGCTACAGTTGGGGAAAAAGGTCAGATAGTAATACCGAAACAGGCACGGGAAGTATTTAATATCAAGCCTGGTGATACAATTTTGCTTCTTGGCGATGAAAAACGAGGTATTGCTATACCGCCAAAGGGAGCATTCACACACTTGATGGAAGTAGCTTTTGAAGAGAAAGAAGACGAATGA","7.50","0.23","7719","MKTPKGKYAWTATVGEKGQIVIPKQAREVFNIKPGDTILLLGDEKRGIAIPPKGAFTHLMEVAFEEKEDE","688656","possible regulator of stationary phase gene expression, see Nolling, et al. (2001).","conserved hypothetical protein","Periplasm, Cytoplasm","Only one hit in gapped BLAST to a predicted regulator of stationary/sporulation gene expression protein: residues 1-70 are48% similar to the protein in Clostridium acetobutylicum (gi|15004795|).SMu0665 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006339
Domain

Transcriptional regulator AbrB
TIGR01439	$\"[11-54]T$	lp_hng_hel_AbrB: transcriptional regulator,

InterPro
IPR007159
Domain

SpoVT/AbrB-like, predicted transcription regulator
PF04014	$\"[12-58]T$	SpoVT_AbrB

","BeTs to 3 clades of COG2002COG name: Regulators of stationary/sporulation gene expressionFunctional Class: KThe phylogenetic pattern of COG2002 is A--------BR----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Apr 26 10:49:37 2002","Fri Apr 26 10:49:37 2002","Tue Mar 19 15:02:29 2002","Mon Dec 17 10:38:14 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0665 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 09:03:18 2002","","No significant hits to the NCBI PDB database.","SMU.730","","No significant hits to the Pfam 11.0 database","Mon Dec 17 10:38:14 2001","24379196","","","Nolling J, Breton G, Omelchenko MV, Makarova KS, Zeng Q, Gibson R, Lee HM, Dubois J, Qiu D, Hitti J, Wolf YI, Tatusov RL, Sabathe F, Doucette-Stamm L, Soucaille P, Daly MJ, Bennett GN, Koonin EV, Smith DR, Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum, J Bacteriol 2001 Aug;183(16):4823-38, PMID: 11466286.","","Fri Apr 26 10:49:37 2002","1","","","SMU.730","" "SMu0666","688659","689393","735","ATGAGATATATTCTAGAAGTAAATGGTCTTACGAAAATTTATCCAGCTTTTGAACTAAAAACTACTAGCTTTCATATTGAGGCTGGCGAAGTTATGGGATTCATAGGTAGAAACGGTGCAGGTAAAACAACAGCGCTAAAATCTATTCTAAATCTTGTACATCCTGAAGCGGGCAGTGTTCGTATTCTTGGAATGAACTATCTGGATAATGAGGATAAAATTAAACAGCAGATTGGTTATGCAGTAGGTGGAGTCAGCTATTATAAAAGGAAAAAGATAAAAGAAATTGTGGCAATTACTCGTGTTTTCTATAATAGTTGGGATGACGAGGAGTATCAACATTATCTCACTGTATTTAATCTTGACGAAAATAAAAAGATTATGGAGCTTTCTGAGGGTATGAAGGTGAAGTTTTATCTTACCTTGGCTCTTTCACATCATGCAAAACTTTTAATTTTAGATGAGCCAACAAGTGGACTTGACCCAGTATCTAGAGATGAGATGAATGAAATTTTCCGAAAACTGGCTAAAAAAGGTGTAGCTATTTTATTTTCCACCCATATCACCAGTGATTTAGATAAATGTGCGGATACGATTACCTACATCAAAAATGGAGAATTACTTTTATCGACAAAGAAAGAAGATTTTATCCATTATTACGCAAAAGAAATAGGTGGTACACCGACACTTGAAGATATTATGGTGCATATCGAAAGAGAAGAGGTGAATCTGTGA","6.50","-2.11","27790","MRYILEVNGLTKIYPAFELKTTSFHIEAGEVMGFIGRNGAGKTTALKSILNLVHPEAGSVRILGMNYLDNEDKIKQQIGYAVGGVSYYKRKKIKEIVAITRVFYNSWDDEEYQHYLTVFNLDENKKIMELSEGMKVKFYLTLALSHHAKLLILDEPTSGLDPVSRDEMNEIFRKLAKKGVAILFSTHITSDLDKCADTITYIKNGELLLSTKKEDFIHYYAKEIGGTPTLEDIMVHIEREEVNL","689392","For other components see SMu0667 (MSD1).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several matches in gapped BLAST to ABC transporter, ATP-binding proteins: residues 4-220 are 56% similar to the protein in Clostridium acetobutylicum (gi|15004794|).Residues 1-239 are 39% similar to the protein from B.halodurans (gi|15613215|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2035 (5e-24).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[129-171]T$	ABC_transporter
PF00005	$\"[29-205]T$	ABC_tran
PS50893	$\"[4-229]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-206]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-210]T$	G3DSA:3.40.50.300
PTHR19222	$\"[5-217]T$	PTHR19222
PTHR19222:SF16	$\"[5-217]T$	PTHR19222:SF16
SSF52540	$\"[4-218]T$	SSF52540

","BeTs to 13 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 8.2e-19. IPB001140A 18-64 IPB001140B 127-165 IPB001140C 182-211","Residues 93-168 are 32% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD353124) which is seen in Q9K9J8_BACHD.Residues 90-210 are 26% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD109690) which is seen in O51520_BORBU.Residues 19-64 are 56% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9RU15_DEIRA.Residues 131-171 are 58% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9KF34_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 10:06:45 2002","Tue Jan 15 11:01:31 2002","Tue Oct 29 10:06:45 2002","Mon Dec 17 10:41:35 2001","Mon Dec 17 10:41:35 2001","Mon Dec 17 10:41:35 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0666 is paralogously related (blast p-value < 1e-3) to SMu0976, SMu1649, SMu1093, SMu0374, SMu0596, SMu0950, SMu0216, SMu0944, SMu1410, SMu0335, SMu1380, SMu0218, SMu1050, SMu1920, SMu1023, SMu1949, SMu1003, SMu0418, SMu1517, SMu1518, SMu0390, SMu0164, SMu0517, SMu0731, SMu1762, SMu0235, SMu0884, SMu0971, SMu0752, SMu0916, SMu1950, SMu1811, SMu0907, SMu1545, SMu1959, SMu0849, SMu1757, SMu1210, SMu0805, SMu1288, SMu0729, SMu1246, SMu1231, SMu1068, SMu0786, SMu0594, SMu1079, SMu0234, SMu1001, SMu1036, SMu0986, SMu1428, SMu1710, SMu0836, SMu0837, SMu0258, SMu0987, SMu1065, SMu0825, SMu1751, SMu1724, SMu1037, SMu0475, SMu0224, SMu0024, SMu0823, SMu0476, SMu1202, SMu1306, SMu0824, SMu1064, and SMu1316 all with ATP-binding capabilities.","Tue Mar 19 15:03:14 2002","Mon Dec 17 10:41:35 2001","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 64 1e-011","SMU.731","","Residues 29 to 205 (E-value = 5.7e-38) place SMu0666 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Dec 17 10:41:35 2001","24379197","","","","","","1","","","SMU.731","" "SMu0667","689393","690043","651","ATGAAAAAACTTTTTTATAAGGAATTGAAACTAACAGCAAACCCGTTGAGTTATTGGTTTATTGCTTTTTCAGCCATGACAATGATTCCAAGCTATCCTATACTTATTGGTTCCGTTTTTATCTGTCTTGGAATTTTTTATACTTACCAGCAGTTGAGAGAATATGATGATATAACATACACGGTTATGTTGCCGGTTAAGAAACAAGACGTAGTTACAGCCAAATATCTATTTGTTTTGTTTATTGAATTGATGGCTTTTATCTCATGTACATTGCTAACGATTATCAGAATGAAATTTTTAGGGAATGCCGCTCCTTACGATATAAATCCCTTGATGAATGCAAATGCGGCTTATCTTGGATATGTAATAATTGTATTTGCAGCATTTAACGGCATTTTTCTTGTAGGCTTTTTTAAAACAGCTTACAAGATTGGAAAACCTCTTATCATATTCTTCGTAGTCAGTTTTATTATAGTAATCTTGGGGGAAATATTACATCATATTCCTGCTTTAGAGAGCCTGAATGAGCTTTCAAACGTAAGCATACCACAGGTTGCTATATTCGTAATTGGTGTCGTCTTGTTTATGTTATGTACATGGTTATCATATCAAAAATCTATAAAAAATTTTGAAGAAATTGATTTGTAA","8.30","2.33","24660","MKKLFYKELKLTANPLSYWFIAFSAMTMIPSYPILIGSVFICLGIFYTYQQLREYDDITYTVMLPVKKQDVVTAKYLFVLFIELMAFISCTLLTIIRMKFLGNAAPYDINPLMNANAAYLGYVIIVFAAFNGIFLVGFFKTAYKIGKPLIIFFVVSFIIVILGEILHHIPALESLNELSNVSIPQVAIFVIGVVLFMLCTWLSYQKSIKNFEEIDL","690042","For other components see SMu0666 (NBD1).","conserved hypothetical protein ","Membrane, Cytoplasm","This is a potential membrane spanning permease.Only one hit in gapped BLAST to a predicted membrane protein: residues 1-216 are 34% similar to the protein in Clostridium acetobutylicum (gi15004793).SMu0667 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[9-23]?$ $\"[29-49]?$ $\"[76-96]?$ $\"[119-139]?$ $\"[149-169]?$ $\"[183-203]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-23]?$	signal-peptide
tmhmm	$\"[7-27]?$ $\"[56-76]?$ $\"[81-103]?$ $\"[109-131]?$	transmembrane_regions

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[2-86]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[25-140]T$	SSF46785

InterPro
IPR002471
Active_site

Peptidase S9, serine active site
PS00708	$\"[208-238]?$	PRO_ENDOPEP_SER

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[139-398]T$	G3DSA:3.40.50.1820
SSF53474	$\"[76-396]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 107-253 are 28% similar to a (PROTEOME FOR COMPLETE VC2276) protein domain (PD140883) which is seen in Q54287_STRHY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 10:02:37 2002","Sat Oct 12 09:31:38 2002","Sat Oct 12 09:31:38 2002","Mon Dec 17 11:08:38 2001","","Mon Dec 17 11:08:38 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0670 is paralogously related (blast p-value < 1e-3) to SMu1170, a predicted alpha/beta superfamily hydrolase.","Thu Jan 24 09:07:31 2002","","No significant hits to the NCBI PDB database.","SMU.737","","No significant hits to the Pfam 11.0 database","Mon Dec 17 11:08:38 2001","24379201","","","","","","1","","","SMU.737","" "SMu0671","692912","693046","135","ATGCTGGTTCTATTGACTAGCCTTTTTAGGAATCGCATTCAAGTTTTTGGCTGGCAGTTCACTTTTGACCTAGCTATTCTGGGATTACTTGGCCTTTATTGTCTGTATTTGCTTAAAAGAAGGAAAGAGATTTAG","10.80","3.93","5259","MLVLLTSLFRNRIQVFGWQFTFDLAILGLLGLYCLYLLKRRKEI","693045","","hypothetical protein","Cytoplasm, Extracellular","No hits in gapped BLAST found.SMu0671 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-31]?$	signal-peptide
tmhmm	$\"[19-37]?$	transmembrane_regions

InterPro
IPR008985
Domain

Concanavalin A-like lectin/glucanase
SSF49899	$\"[306-349]T$	ConA_like_lec_gl

InterPro
IPR012332
Domain

Phage P22 tailspike
G3DSA:2.160.20.20	$\"[161-445]T$	P22_tailspike

noIPR
unintegrated

unintegrated
PTHR23124	$\"[71-298]T$	PTHR23124
PTHR23124:SF7	$\"[71-298]T$	PTHR23124:SF7

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 09:08:45 2002","Mon Dec 17 12:30:10 2001","Thu Jan 24 09:08:45 2002","Mon Dec 17 12:30:10 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0672 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 09:08:45 2002","","No significant hits to the NCBI PDB database.","SMU.739c","","No significant hits to the Pfam 11.0 database","Mon Dec 17 12:30:10 2001","24379203","","","","","","1","","","SMU.739c","" "SMu0673","695056","696114","1059","ATGTGGCGCATTTTAGGAAACTCTTCATTTTCCCAAACGGGTCTGCGCAAACGTTATCAAGAAGCAAAGCAACTGCTTTTATGGGAAAGTGTAGGATGGACTAGGGAAGATGTAAAGCAATTAGCTAAAAAGGATTTGCAGCCTTCGGCCTTTCGCATTGGCTCACAGGCTTTTAATTTCTTATGGCAAGCTGCTTATGGTAATAAAGAGCCGCAAAAACTGCTGTCTATTGTTCTAGATATGGCTGCTATGCCAGAAGAATTATCTGGTGATTTACAAGAAAATCAAGAGTTAGTTCATCGTTTTTCTGACGATTTAGCACCAGACAATACTTTTTGGCATGAGTTTTCACTTCTGGTTCAAGAGATTTTTCCAAAAGACACACTCAGTGCTAAGACTAATTTTGCCAAACGTATCCATCAATTTCGCTATGTCATTTCCAGTCAGCAGGCGCAGTGGATTCGTGATCATTTGAGAAATGAAAAAATGACTGATTCTCAGGCTTTGGCGCGGTTTTTAAGAAAGAAAAAGAGAAAAGTTTGGTATCATCCAACCTATGATTACACACTTTATGATTCTGCCCGTCTGCATAATAAGGTTGCTTTTAAGGATGGACAGATGATTTATCCAGATGACTCTTATCGCCTTAATTTTAAGGTGTTATTAAATTTTCATACGGAATTTATTCTTGATAATGAAGGACATTTCTTGAATGAAATTGATGCTGAACATATCACGCAAAATGGGATTATTAATGGTGCCAGTTTTAATTATGCTAACAGTGGCAATCAATGTCATTGGGAGTTAGATGTTAATCCGACCAAATCACATGATCCTCTCTTTAGAGACGCGGTTATTGCCACTAAGGATTTACGTTTTACGGCACCTAAATATATCCTGAAAAAAATCGAAGCAGCATCAGAAGAGGATTGGCAAAAAAGTTATTTTAATAAAAAAGGACTCTATGCTAGTGGATGCAAGAGCAATTTTAAAGCAGTTAAGCATTTGATCCGACAATTCAAAAAAGAACTTTTTAAACTGAAGTGGACAAAAAATTGA","10.10","12.81","41418","MWRILGNSSFSQTGLRKRYQEAKQLLLWESVGWTREDVKQLAKKDLQPSAFRIGSQAFNFLWQAAYGNKEPQKLLSIVLDMAAMPEELSGDLQENQELVHRFSDDLAPDNTFWHEFSLLVQEIFPKDTLSAKTNFAKRIHQFRYVISSQQAQWIRDHLRNEKMTDSQALARFLRKKKRKVWYHPTYDYTLYDSARLHNKVAFKDGQMIYPDDSYRLNFKVLLNFHTEFILDNEGHFLNEIDAEHITQNGIINGASFNYANSGNQCHWELDVNPTKSHDPLFRDAVIATKDLRFTAPKYILKKIEAASEEDWQKSYFNKKGLYASGCKSNFKAVKHLIRQFKKELFKLKWTKN","696113","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypothetical proteins:residues 18-348 are 45% similar to a hypothetical in S.pyogenes (gi|15674627|)and in (gi|15675322|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0713 (2e-63).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 15:16:38 2002","Mon Dec 17 12:33:45 2001","Tue Mar 19 15:17:28 2002","Mon Dec 17 12:33:45 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0673 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 09:09:14 2002","","No significant hits to the NCBI PDB database.","SMU.741","","No significant hits to the Pfam 11.0 database","Mon Dec 17 12:33:45 2001","24379204","","","","","","1","","","SMU.741","659" "SMu0674","696178","697008","831","ATGGTTACTAAAAGAAATTTCATGACAGAAAAAATACGCTTGATTGCAACAGATATGGACGGTACTTTTTTAGATGCTTCCGGTCAGTTTGATCATCAGCGCTTAGATGATTTGTTAAAAAAATTTAAGGCAAAAAATCTTATTTTCACTATTGCCAGCGGCCGTTCGCTATTGACTTTAGAAAAATTGTTCAAGGATTTTACAGATCGTATTGCAATTATAGCTGAAAATGGAAGTTTGATTCAATATAAAAATCAAGTGCTGTTTGAACAGTTAATGACTCCCTCTCAGTATCTGGATTTAACGGCTAAAATTTTGGAAAATCCATATAACCAAGGTGTTGAATTACTCTTATCCGGTAAAAAGGCCGCTTATATTTTGGCGGAGAGTCCTCAGAGTTATATTGATTTCATGAAAGGGTATTACGAAAATATTCAGTTAGTTGAGAATTTTGAACAGTTGGATGATGCTATTTTTAAAATCACAACTCAATTTCCAGCGGAATATGTTCATAAAGGAGCTGCTTGGTTAAATGAAAGACTCCCGCATATTCAAGCTGTAACAACAGGATTCGAGTCTATTGATATTATTTTACGGGGAGCCAATAAGGGATTTGGTCTTAGCCATCTCTGCCAAGTTTTAAAGTTAAAATCTGAACATGTTTTAGCTTTTGGTGATAATTTAAACGACTTTGAAATGATGGATTTTGCAGACGTTGCTATTGCACCTGAAAATGCGCGTGTGGAAATTAAAGAGCTTGCAGATGAAGTCATCCCTCATCATCAGGAACAATCAGTAATAACTTATATGGAAGGTATGATAAAGGAATGA","5.00","-10.34","31451","MVTKRNFMTEKIRLIATDMDGTFLDASGQFDHQRLDDLLKKFKAKNLIFTIASGRSLLTLEKLFKDFTDRIAIIAENGSLIQYKNQVLFEQLMTPSQYLDLTAKILENPYNQGVELLLSGKKAAYILAESPQSYIDFMKGYYENIQLVENFEQLDDAIFKITTQFPAEYVHKGAAWLNERLPHIQAVTTGFESIDIILRGANKGFGLSHLCQVLKLKSEHVLAFGDNLNDFEMMDFADVAIAPENARVEIKELADEVIPHHQEQSVITYMEGMIKE","697007","","conserved hypothetical protein, Cof family","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 12-274 are 49% similar to the protein in S.pyogenes (gi15674657). Residues 12-273 are 50% similar to the protein from S.pneumoniae (gi15903168).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0725 (1e-77).","

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[14-270]T$	Cof-subfamily

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[14-243]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[15-270]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[10-274]T$	G3DSA:3.40.50.1000
SSF56784	$\"[8-275]T$	SSF56784

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[6-265]T$	Cof-subfamily

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[6-237]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[7-265]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[3-269]T$	G3DSA:3.40.50.1000
PTHR10000	$\"[187-250]T$	PTHR10000
SSF56784	$\"[1-270]T$	SSF56784

","BeTs to 12 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","***** IPB000150 (Cof protein) with a combined E-value of 9.6e-28. IPB000150A 3-17 IPB000150B 37-46 IPB000150C 216-248","Residues 3-102 are 29% similar to a (PROTEOME COMPLETE) protein domain (PD201280) which is seen in O83314_TREPA.Residues 5-229 are 27% similar to a (RNPA-LICA R4 ORF) protein domain (PD107065) which is seen in YRR4_MYCCA.Residues 5-46 are 64% similar to a (PROTEOME COMPLETE SIPU BH0497) protein domain (PD306139) which is seen in Q9CHC1_LACLA.Residues 47-183 are 40% similar to a (PROTEOME COMPLETE YKIF IBPA-GYRB) protein domain (PD034656) which is seen in Q9CHC1_LACLA.Residues 6-269 are 25% similar to a (PROTEOME COMPLETE PM0231) protein domain (PD400978) which is seen in Q9CP34_PASMU.Residues 4-57 are 44% similar to a (PROTEOME COMPLETE YCSE PROTEINS) protein domain (PD382681) which is seen in P96741_BACSU.Residues 5-46 are 50% similar to a (COMPLETE PROTEOME BU028 PLDB-METR) protein domain (PD388374) which is seen in Q9KS95_VIBCH.Residues 189-248 are 48% similar to a (PROTEOME COMPLETE HYDROLASE ATPASE) protein domain (PD001342) which is seen in YIDA_ECOLI.Residues 5-75 are 40% similar to a (PROTEOME COMPLETE MG265 VCA0243) protein domain (PD002063) which is seen in O87560_BACFI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 13:41:15 2002","Tue Aug 29 15:34:31 2006","Tue Aug 29 15:34:31 2006","Mon Dec 17 12:40:07 2001","Mon Dec 17 12:40:07 2001","Mon Dec 17 12:40:07 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0675 is paralogously related (blast p-value < 1e-3) to SMu0655, SMu0388, SMu0367, SMu0461,SMu1666, SMu1012,SMu0674, and SMu0442, all predicted conserved hypothetical proteins.","Thu Jan 17 13:41:15 2002","","No significant hits to the NCBI PDB database.","SMU.743","","Residues 4 to 241 (E-value = 2.5e-07) place SMu0675 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Mon Dec 17 12:40:07 2001","24379206","","","","","","1","","","SMU.743","542" "SMu0676","697828","699324","1497","ATGGGTTTATTTAATCGCTTATTTGGTAAGAAAAGACAAGAAGAAAAGTCAACAACGGATTCTATTGAAGAAGCCGCTGAACAAGAAGTTACACAAGAAAAGCCAGCACTGCTGGCAGAAACTGCTGAAACAGCAGAGAGTCAGCAGTCTGTTTATGAAAAAGATGTGACAGAAAGTCAAGCTGAACAAGTATCAGATGCACGAATAATTGAAGACGGACAGAATTCGAAAGAACCAGCAGCTAGTGGGCATTCCGTCCAAGAACATAAGCAACAGCCTGTCCAACACCAACAAGAAGTGTTTCATTCTGAAAATTCTGTAGCCGCTGTACAAAATAATACTGAGACTATGCCTTCGCAGCAAAAAAAAGACGAAAAGCCAAATCAATCGCCGGATTTCATGGCAGAATACTATGCACGTAAGGCTGAATTAGCTCAAAAAGTGGAAAGCCAAAAACCAGCAGAGACTGCTGAGCAAGAAAGCCAAACGACACTCTCGGACCAAAAGGAGACTGAAACAGCTGTCAATCAGTCTGAAGAAGAAGCTTCCAGTCAAATAGCAGAATCTGTTGAAAGCGAGGAAGAAAAGTACAATCGCAGTCTGAAAAAAACCCGCACTGGCTTTGGTGCGAGACTTAATGCTTTCTTGGCTAATTTTCGTAATGTTGATGAAGAATTCTTTGAAGACTTGGAAGAGATGCTCATTCTTTCTGATGTCGGTGTTCAGGTTGCGTCAACCTTGACAGAAGATTTACGCTATGAAGCTAAATTAGAAAAGGCCAAGAAACCTGAAGCTCTTCGCCGTGTCATTATTGAAAAACTAGTTGATATTTATGACAAAGACGGTCAGTTTAATGAAAAAATTAATTTTCAGAACGATCTTACTGTTATGCTCTTTGTAGGAGTTAATGGTGTTGGTAAAACGACTTCCATTGGGAAATTAGCCTATAAATATAAACATCAAGGCAAGAAAGTTATGCTGGTTGCAGCCGATACTTTTCGTGCGGGAGCCGTTGCTCAGTTAGCTGAATGGGGCCGCCGTGTTGATGTTCCAGTTGTTACTGGTCCAAAAAATGCTGATCCAGCTAGTGTTGTCTATGATGGTGTTGAAAGGGCAGTTGCAGCAGATGTTGATATTCTTATGATTGATACAGCAGGTCGCCTGCAAAATAAGGATAATCTCATGGCGGAATTGGAAAAGATTGGCCGTGTTGTGAAACGTGTTATTCCAGATGCTCCTCATGAAACGTTGCTTACTCTTGATGCTTCAACGGGACAAAATGCCCTTGTTCAGGCTAAGGAATTTTCAAAAATCACACCTTTGACCGGTCTGATTTTAACAAAAATTGATGGAACTGCCAAAGGCGGTGTGGTGCTTGCTATTCGGCAAGAACTTGCGATTCCTGTTAAATTTATTGGTTTTGGTGAAAAAATTGATGATATTGGTGAATTTCATTCTGAAGACTTCATGAGAGGACTTTTAGAAGGATTGCTATGA","4.70","-25.23","55173","MGLFNRLFGKKRQEEKSTTDSIEEAAEQEVTQEKPALLAETAETAESQQSVYEKDVTESQAEQVSDARIIEDGQNSKEPAASGHSVQEHKQQPVQHQQEVFHSENSVAAVQNNTETMPSQQKKDEKPNQSPDFMAEYYARKAELAQKVESQKPAETAEQESQTTLSDQKETETAVNQSEEEASSQIAESVESEEEKYNRSLKKTRTGFGARLNAFLANFRNVDEEFFEDLEEMLILSDVGVQVASTLTEDLRYEAKLEKAKKPEALRRVIIEKLVDIYDKDGQFNEKINFQNDLTVMLFVGVNGVGKTTSIGKLAYKYKHQGKKVMLVAADTFRAGAVAQLAEWGRRVDVPVVTGPKNADPASVVYDGVERAVAADVDILMIDTAGRLQNKDNLMAELEKIGRVVKRVIPDAPHETLLTLDASTGQNALVQAKEFSKITPLTGLILTKIDGTAKGGVVLAIRQELAIPVKFIGFGEKIDDIGEFHSEDFMRGLLEGLL","699323","For other 'fts' genes, see SMu0013 (ftsH); SMu0501 (ftsA);SMu0502(ftsZ);SMu0500 (ftsQ); SMu0650 (ftsW); SMu0411 (ftsL); SMu1209 (ftsX); SMu1210 (ftsE) and SMu1483 (ftsK). From Genbank:[gi:16078658]This protein is involved in secretion of extracellular proteins and localization of spore-forming proteins .","cell division protein FtsY; signal recognition particle (docking protein)","Cytoplasm","Matches in gapped BLAST to signal recognition particle:residues 295-487 are 40% similar to the previously published enzyme in S.mutans (gi2500883). Residues 1-498 are 54% similar to the protein in S.pyogenes (gi15674659)and are 53% similar to the protein from S.pneumoniae (gi15903166).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0727 (1e-136).","

InterPro
IPR000897
Domain

GTP-binding signal recognition particle SRP54, GTPase
PD000819	$\"[297-387]T$	SRP54
PF00448	$\"[293-495]T$	SRP54
PS00300	$\"[468-481]T$	SRP54

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[293-446]T$	AAA

InterPro
IPR004390
Family

Cell division transporter substrate-binding protein FtsY
TIGR00064	$\"[221-494]T$	ftsY

InterPro
IPR013822
Domain

GTP-binding signal recognition particle SRP54, helical bundle
G3DSA:1.20.120.140	$\"[199-283]T$	SRP54_helical
PF02881	$\"[197-279]T$	SRP54_N
SSF47364	$\"[199-283]T$	SRP54

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[287-494]T$	G3DSA:3.40.50.300
PTHR11564	$\"[266-495]T$	PTHR11564
PTHR11564:SF6	$\"[266-495]T$	PTHR11564:SF6
SSF52540	$\"[289-495]T$	SSF52540

","BeTs to 16 clades of COG0552COG name: Signal recognition particle GTPase FtsYFunctional Class: NThe phylogenetic pattern of COG0552 is amtkyqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000897 (GTP-binding signal recognition particle (SRP54) domain) with a combined E-value of 5.2e-70. IPB000897A 296-315 IPB000897B 327-341 IPB000897C 378-398 IPB000897D 413-455 IPB000897E 468-495","Residues 235-493 are 60% similar to a (SIGNAL RECOGNITION PARTICLE GTP-BINDING RNA-BINDING) protein domain (PD000819) which is seen in Q9CHB9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 12:59:03 2006","Mon Dec 17 12:42:41 2001","Fri Sep 8 12:59:03 2006","Mon Dec 17 12:42:03 2001","Mon Dec 17 12:42:03 2001","Mon Dec 17 12:42:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0676 is paralogously related (blast p-value < 1e-3) to SMu0968,a predicted signal recognition particle protein subunit, SMu1375,a predicted chromosome condensation and segregation SMC protein, SMu0630 and SMu0018,both predicted immunodominant glycoprotein IDG-60; general stress protein GSP-781; glucan binding protein B, SMu0082,a predicted peptidyl-prolyl isomerase(trigger factor), SMu0382,a predicted translation initiation factor IF2, and SMu0556,a predicted cell surface antigen I/II, SpaP protein precursor, pac protein precursor; saliva-interacting protein;PAGS-5.","Thu Jan 24 09:25:45 2002","Fri Sep 8 12:59:03 2006","pdb1FTS Signal Recognition Particle Receptor From E. Coli 240 2e-064pdb1NG1 N And Gtpase Domains Of The Signal Sequence Recogn... 140 4e-034pdb2NG1 N And Gtpase Domains Of The Signal Sequence Recogn... 138 1e-033","SMU.744","","Residues 197 to 279 (E-value = 4.9e-13) place SMu0676 in the SRP54_N family which is described as SRP54-type protein, helical bundle domain (PF02881)Residues 293 to 495 (E-value = 2.3e-111) place SMu0676 in the SRP54 family which is described as SRP54-type protein, GTPase domain (PF00448)","Fri Sep 8 12:59:03 2006","24379207",""," Hasona A, Zuobi-Hasona K, Crowley PJ, Abranches J, Ruelf MA, Bleiweis AS, Brady LJ.Membrane Composition Changes and Physiological Adaptation by Streptococcus mutans Signal Recognition Particle (SRP) Pathway Mutants.J Bacteriol. 2006 Nov 3;PMID: 17085548Kremer BH, van der Kraan M, Crowley PJ, Hamilton IR, Brady LJ, Bleiweis ASCharacterization of the sat operon in Streptococcus mutans: evidence for a role of Ffh in acid tolerance.J Bacteriol 2001 Apr;183(8):2543-52PubMed: 11274114PMID: 11274114Gutierrez JA, Crowley PJ, Cvitkovitch DG, Brady LJ, Hamilton IR, Hillman JD, Bleiweis ASStreptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress.Microbiology 1999 Feb;145 ( Pt 2):357-66PubMed: 10075418PMID: 10075418 Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P.and Bleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 8763945","Gill,D.R., Hatfull,G.F. and Salmond,G.P.A new cell division operon in Escherichia coliMol. Gen. Genet. 205 (1), 134-145 (1986)PubMed: 3025556Gill,D.R. and Salmond,G.P.The identification of the Escherichia coli ftsY gene product: anunusual proteinMol. Microbiol. 4 (4), 575-583 (1990)PubMed: 2161989Luirink,J., ten Hagen-Jongman,C.M., van der Weijden,C.C.,Oudega,B., High,S., Dobberstein,B. and Kusters,R.An alternative protein targeting pathway in Escherichia coli:studies on the role of FtsYEMBO J. 13 (10), 2289-2296 (1994)PubMed: 8194520Montoya,G., Svensson,C., Luirink,J. and Sinning,I.Crystal structure of the NG domain from the signal-recognitionparticle receptor FtsYNature 385 (6614), 365-368 (1997)PubMed: 9002525","Tue Mar 26 09:28:54 2002","Mon Dec 17 12:55:26 2001","1","","","SMU.744","311" "SMu0677","700765","699401","1365","ATGATTAGTACACAACAGACAGATAAAGTCTCTCGTAAAACTCAGCTTTCTATCATAGCAACTGCTTTGGTTGGTTTTTCTGGTATTCTATCAGAAACAAGCATGAATGTGACTTTCACCAAATTAATGACTATTTTCCATTTGCCTTTAAGTAGTCTGCAATGGATTACAACCGTTTATCTCTTGGCAGTCGCCATTTCTATGACACTGAGCGCCACATTACAACAAAATGTTAAAGAGCGTCTACAATTCACAATAGCAGTCTTGCTCTTTCTTCTAGGTACAGTAACATGTATCATCTCTGCTCATTTTGGCTTGATGATTATTGGCAGAGCTCTGCAGGGGGCTGGTACGGGAATTGCTATGCCTTTGATGTTTAACCTTATTATTGAGCGCATTCCTATCAACAAGATTGGAACCTATATGGGAATTGGCGGACTTATCATGAGTTTAGCTCCTGCTTTTGGACCTACTTATGGCGGTTTCATGATTGCCCATTTTTCTTGGCAATGGATTTTTTTACTAACACTGCCAGTTCCTGTAATTGCTTTAATTATCAGTTATTTTTCTTTGGAAAATTCACCTAAAACTAGTAAACGTCCCTTTGATTTCATCAGTTTTCTTTTATTAGCGATAGCTTTGTCCTTCTTTTTAATCCTTATTTCCGGACTTGAATCAGGTTCCCTTAATTGGTTGGCTTTAATCATTTTTGGCTTTGCTCTTATTTTCTTTGTGTTTAGAAGTCTCAAATTGCAGACGCCTTTTTTAGATATTCGAATCTTAAAACAAGCTCCTGTTCTTTTAGGCTTAATCCCTTTTTTCATCTATCAATTTTCAAATTTAGCTTCTAACTTTGTTATTCCTAATTTTCTTGTTCAAGCAGAGCACATCTCAACTACAATCGCCGGTTTTGTGTTACTGCCAGGAACACTTTTAGGTGGGATCTTAGCACCATTTTTTGGAAAACTTTATGACTTAAAGGGCCCTAAATTATCTCTTTATTGGGGAAATACTCTTTTTGCTGTTAGCCTTGGTATCTTCGCTTTATGGATAAACTCTTTAACCATTATGTTAATGATCCTTGTCTACATCATTTTCACTTTCGGACGTAATATGGCTTTTAACAACACTATGGCAGTTGCTATTTCACAATTACCCAAAAATAAAACAGCGGATGCTACTGCTATTTTCCAAATGATGCAGCAATTTGCCGGTGCCTTAGGAACAGCTCTATCATCAGTTGCCCTCCAATTAGCCCCAAATATGACCAGTGGTGTGAAATTTATCTTTTCAACTTTATTTACCTTGGTTATCCTTATTTTCTTTTGTTTCAAAATGCTCTTTGCTTCCTTGAAAAAGTATTAA","10.70","15.85","50004","MISTQQTDKVSRKTQLSIIATALVGFSGILSETSMNVTFTKLMTIFHLPLSSLQWITTVYLLAVAISMTLSATLQQNVKERLQFTIAVLLFLLGTVTCIISAHFGLMIIGRALQGAGTGIAMPLMFNLIIERIPINKIGTYMGIGGLIMSLAPAFGPTYGGFMIAHFSWQWIFLLTLPVPVIALIISYFSLENSPKTSKRPFDFISFLLLAIALSFFLILISGLESGSLNWLALIIFGFALIFFVFRSLKLQTPFLDIRILKQAPVLLGLIPFFIYQFSNLASNFVIPNFLVQAEHISTTIAGFVLLPGTLLGGILAPFFGKLYDLKGPKLSLYWGNTLFAVSLGIFALWINSLTIMLMILVYIIFTFGRNMAFNNTMAVAISQLPKNKTADATAIFQMMQQFAGALGTALSSVALQLAPNMTSGVKFIFSTLFTLVILIFFCFKMLFASLKKY","699406","","drug-export protein; multidrug resistance protein","Membrane, Cytoplasm","Several matches in gapped BLAST to drug-export protein; multidrug resistance protein: residues 5-453 are 52% similar to the protein in S.pyogenes (gi|15674660|). Residues 9-447 are 37% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673521|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1088 (1e-59).","

InterPro
IPR001411
Family

Tetracycline resistance protein TetB
PR01036	$\"[20-44]T$ $\"[111-131]T$ $\"[141-165]T$ $\"[206-224]T$ $\"[301-325]T$	TCRTETB

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[17-450]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[21-417]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[3-206]T$ $\"[252-448]T$	PTHR10074
PTHR10074:SF57	$\"[3-206]T$ $\"[252-448]T$	PTHR10074:SF57
SSF103473	$\"[1-442]T$	SSF103473

","BeTs to 13 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","***** IPB003662 (General substrate transporters) with a combined E-value of 5e-07. IPB003662A 107-139","Residues 147-189 are 44% similar to a (TRANSMEMBRANE COMPLETE PROTEOME RESISTANCE TRANSPORT) protein domain (PD001095) which is seen in Q9L6D2_CORGL.Residues 94-146 are 47% similar to a (RESISTANCE TRANSMEMBRANE TETRACYCLINE) protein domain (PD413732) which is seen in Q9CFE0_LACLA.Residues 343-447 are 30% similar to a (PROTEOME COMPLETE TRANSPORTER) protein domain (PD395311) which is seen in Q9CFE0_LACLA.Residues 255-342 are 45% similar to a (COMPLETE PROTEOME TRANSPORTER) protein domain (PD279163) which is seen in Q9CFE0_LACLA.Residues 354-416 are 36% similar to a (PROTEOME HSP18 COMPLETE ORFB) protein domain (PD414878) which is seen in Q9RLJ4_OENOE.Residues 250-453 are 22% similar to a (TRANSMEMBRANE EFFLUX-LIKE GRAM-POSITIVE) protein domain (PD189466) which is seen in O31337_BACCE.Residues 256-330 are 34% similar to a (TRANSMEMBRANE TRANSPORT TRANSPORTER COMPLETE PROTEOME) protein domain (PD000082) which is seen in O35018_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 09:28:50 2002","Mon Dec 17 12:58:43 2001","Sat Oct 12 09:39:36 2002","Mon Dec 17 12:58:43 2001","Mon Dec 17 12:58:43 2001","Mon Dec 17 12:58:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0677 is paralogously related (blast p-value < 1e-3) to SMu1460, SMu0119, SMu1914, SMu1173, and SMu1287, permease-related proteins.","Thu Jan 24 09:27:44 2002","","No significant hits to the NCBI PDB database.","SMU.745c","","No significant hits to the Pfam 11.0 database","Mon Dec 17 12:58:43 2001","","","","","","","1","","","SMU.745c","" "SMu0678","701690","700875","816","ATGATTCGTTTTCTCATTTTAGCGGGTTACTTTGAATTGGGCATGTACTTACAATTATCTGGGAAATTAGATCGCTATATTAACAGTCACTATTCTTACTTAGCTTATATTTCCATGGCTTTATCCTTTATTCTGGCCCTTGTGCAGTTAACCATTTGGATGAAAAGGTTAAAAATGCACTCTCACTTATCTGGAAAAGCCGCTAAATTTTTTAGTCCTATTATTCTAGCTATCCCCGTTTTTATTGGACTTTTAGTCCCAACAGTGCCACTTGATTCAACAACCGTCTCTGCCAAAGGCTATCATTTCCCATTGGCTGCAGGATCAACTACTTCAGGAACTAGCTCAGATGGAACTCGCGTTCAATACTTAAAACCTGATACTAGTCTTTATTTCACAAAATCAGCTTATCAAAAAGAAATGCGAGCAACTTTAAAAAAATATAAAGGATCTGGAAAACTGCAAATTACAACGCAAAATTACATGGAAGTGATGGAGATTATCTACCTCTTTCCTGATGAATTCAAAAACCGTCAAATTGAATATGTCGGCTTTATTTACAATGATCCCAAAGATAAGAACAGTCAATTTCTCTTTCGCTTTGGCATCATTCACTGTATTGCTGATTCGGGTGTCTATGGTTTGTTAACGACAGGTGGACAAACGCATTATCAAAACAACACTTGGGTTACGGTTAGTGGAAAACTTGCTATTGAATACAATCAAAACCTGAAACAAACTCTGCCTGTTCTTCATATTTCTCAGAGTTCACAGACAATGCAACCCAAAAATCCATATGTTTATCGTGTGTTTTAA","10.40","13.62","30825","MIRFLILAGYFELGMYLQLSGKLDRYINSHYSYLAYISMALSFILALVQLTIWMKRLKMHSHLSGKAAKFFSPIILAIPVFIGLLVPTVPLDSTTVSAKGYHFPLAAGSTTSGTSSDGTRVQYLKPDTSLYFTKSAYQKEMRATLKKYKGSGKLQITTQNYMEVMEIIYLFPDEFKNRQIEYVGFIYNDPKDKNSQFLFRFGIIHCIADSGVYGLLTTGGQTHYQNNTWVTVSGKLAIEYNQNLKQTLPVLHISQSSQTMQPKNPYVYRVF","700880","","conserved hypothetical protein","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-271 are 71% similar to the protein in S.pyogenes (gi|15674664|)and are 62% similar to the protein from S.pneumoniae (gi|15902848|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0728 (1e-110).","

InterPro
IPR015402
Family

Protein of unknown function DUF1980
PF09323	$\"[1-178]T$	DUF1980

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-271 are 34% similar to a (COMPLETE PROTEOME AMYE-SRFA FOR) protein domain (PD356990) which is seen in P94394_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 09:29:09 2002","Mon Dec 17 13:03:35 2001","Thu Jan 24 09:29:09 2002","Mon Dec 17 13:03:35 2001","","Mon Dec 17 13:03:35 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0678 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 09:29:09 2002","","No significant hits to the NCBI PDB database.","SMU.746c","","No significant hits to the Pfam 11.0 database","Mon Dec 17 13:03:35 2001","24379209","","","","","","1","","","SMU.746c","312" "SMu0679","702592","701687","906","ATGGCGATTTTTAATCATTTACCAAGCAGTGTTCTGCAATGCTTGGCAATCTTCCTTTCTATTATCATCGAAGCTCTGCCATTTATTCTGCTAGGTGCTATTTTGTCGGGTTTTATTGAAGTTTATCTGACACCTGATATTGTTCAAAAATATCTTCCTAAAAATAAAATAGGCCGTATTCTTTTTGGAACTTTTGTTGGTTTCATCTTTCCTTCTTGTGAATGTGGGATTGTCCCTATTGTCAATCGTTTTTTGGAAAAAAAGGTACCTAGCTACACTGCCATTCCTTTTTTAGCAACAGCTCCTATTATCAATCCTATCGTTCTTTTTGCAACGTTTTCAGCCTTTGGCAATTCTTGGCGTTTTGTTTTTTTGAGGCTGTTTGGAGCTATTATTGTAGCTATTTCTCTAGGAATTTTACTTGGCTTTATAGTGGATGAACATATCATCAAGGAAAGTGCCAAACCTTGTCATTTCCACGATTATTCTCATAAAAAAGCATATCAAAAGATTTTTTATGCATTAGCTCATGCAGTAGACGAACTTTTTGACACAGGACGTTACCTTATCTTTGGGAGTTTTGTGGCTGCTAGCATGCAAATTTATGTACCAACGCGTATTTTGACTTCTATTGGTCACAATCCACTGACGGCTATCTTAATCATGATGCTCCTAGCCTTTATCCTTTCGCTGTGCAGTGAAGCCGATGCTTTCATTGGAACTTCTTTGTTGGCGACCTTTGGTGTGGCTCCCGTTGTTGCATTTCTTCTTATTGGACCCATGGTTGATATCAAAAATCTAATGATGATGAAAAATGCTTTTAAAACGAAGTTTATTCTGCAATTTGTTGGCACATCAAGTCTTATCATTATCATTTATTGCTTGATTGTGGGGGTGATGCAATGA","8.70","6.39","33261","MAIFNHLPSSVLQCLAIFLSIIIEALPFILLGAILSGFIEVYLTPDIVQKYLPKNKIGRILFGTFVGFIFPSCECGIVPIVNRFLEKKVPSYTAIPFLATAPIINPIVLFATFSAFGNSWRFVFLRLFGAIIVAISLGILLGFIVDEHIIKESAKPCHFHDYSHKKAYQKIFYALAHAVDELFDTGRYLIFGSFVAASMQIYVPTRILTSIGHNPLTAILIMMLLAFILSLCSEADAFIGTSLLATFGVAPVVAFLLIGPMVDIKNLMMMKNAFKTKFILQFVGTSSLIIIIYCLIVGVMQ","701692","","conserved hypothetical protein, permease-like","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-300 are 69% similar to the protein in S.pyogenes (gi15674665)and are 60% similar to the protein from S.pneumoniae (gi15900786).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0729 (1e-129).","

InterPro
IPR005524
Family

Protein of unknown function DUF318, transmembrane
PF03773	$\"[10-299]T$	DUF318

","BeTs to 8 clades of COG0701COG name: Predicted permeasesFunctional Class: RThe phylogenetic pattern of COG0701 is amt--qvCebr----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 32-135 are 37% similar to a (PROTEOME COMPLETE) protein domain (PD120871) which is seen in P72867_SYNY3.Residues 29-175 are 25% similar to a (PROTEOME COMPLETE MJ0584 TRANSMEMBRANE) protein domain (PD120868) which is seen in Y584_METJA.Residues 169-296 are 42% similar to a (PROTEOME COMPLETE OF COLI) protein domain (PD023797) which is seen in P94395_BACSU.Residues 18-140 are 49% similar to a (PROTEOME COMPLETE OF COLI) protein domain (PD005020) which is seen in P94395_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 09:40:30 2002","Fri Sep 8 13:07:57 2006","Fri Sep 8 13:07:57 2006","Mon Dec 17 13:04:35 2001","","Mon Dec 17 13:04:35 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0679 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 17 13:06:48 2001","","No significant hits to the NCBI PDB database.","SMU.747c","","Residues 10 to 299 (E-value = 7.2e-116) place SMu0679 in the DUF318 family which is described as Predicted permease (PF03773)","Mon Dec 17 13:04:35 2001","24379210","","","","","","1","","","SMU.747c","313" "SMu0680","702575","702751","177","ATGATTAAAAATCGCCATAAAATCTATTTCTTGACTTTCTTGTCAGCTTTCTTTTCTTTATCATCTGGGAATTCAACTTTTTCTAAGCCTTCAGGGAGTTTAGCAAAATTTTCCATCATTTTTTCTAATTCATCATTTTTCTTGAATGTAATCGCCATAAGAATACCTCATTTCTAA","11.90","6.45","6548","MIKNRHKIYFLTFLSAFFSLSSGNSTFSKPSGSLAKFSIIFSNSSFFLNVIAIRIPHF","702750","","hypothetical protein","Cytoplasm, Extracellular","No hits in gapped BLAST found.SMu0680 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-23]?$	signal-peptide
tmhmm	$\"[9-27]?$ $\"[33-53]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 09:29:50 2002","Mon Dec 17 13:07:52 2001","Thu Jan 24 09:29:50 2002","Mon Dec 17 13:07:52 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0680 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 09:29:50 2002","","No significant hits to the NCBI PDB database.","SMU.748","","No significant hits to the Pfam 11.0 database","Mon Dec 17 13:07:52 2001","24379211","","","","","","1","","","SMU.748","" "SMu0681","703579","703472","108","ATGCTTTCTAATGTTCTTTCAAGATCTGTTGTTTCACCAAATGTTGACATTCCTAATTCAATGGTCATTCTTTCTCCTCTTCTAATCTCTATCTCCAATTATCACTAA","7.50","0.21","3793","MLSNVLSRSVVSPNVDIPNSMVILSPLLISISNYH","703477","","hypothetical protein","Extracellular, Periplasm","No hits in gapped BLAST found.SMu0681 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 09:37:09 2002","Mon Dec 17 13:09:21 2001","Thu Jan 24 09:37:09 2002","Mon Dec 17 13:09:21 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0681 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 09:37:09 2002","","No significant hits to the NCBI PDB database.","SMU.750c","","No significant hits to the Pfam 11.0 database","Mon Dec 17 13:09:21 2001","24379212","","","","","","1","","","SMU.750c","" "SMu0682","703952","706078","2127","ATGGAAATTATTGAAAAAATTGCTGAAGATTTGCACTTAAAAGAAAGTCAAATACAAAAAGTTTTAGATTTAGCTGCTCAGGGAAATACGATTCCTTTTATTGCTCGTTACCGTAAAGAAATGACTGGCAATCTTGATGAAGTGGAAATTAAGTCTATTATTGATCTGGATAAAAATTTAACAGCATTAGCCGAACGTAAGGCAACTGTTTTAGCGAAAATTGAAGGACAAGGTAAACTAACAGCTGAATTGCAAGAAGCGATTGAAGCGGCTTCAAAGTTAGCTGATGTTGAAGAACTTTATCTTCCATATAAAGAAAAGCGGCGAACAAAAGCAACAATTGCTCGTGAAAATGGACTTTTTCCATTGGCGCGCCTCATTTTACAAAATGTTTCGGATTTGGAAAAACAAGCAGAAACTTTTGTAAATAAAACCTTTCCTACAGCTGAAAAAGCTCTTACTGGAGCCATAGATATTTTGATTGAAGCCTTATCAGATGATACAAAGTTGCGCTCATGGACCTATAATGAAATTTGGACAAATAGTTTTATTTTGTCGAAAGTCAAAGATCAGGAACTTGATGAAAAAAAGGTTTTTCAAATTTATTATGATTTTTCCGAAAAAGTTGCAAAAATTCAAGATTATCGTGTTTTAGCTCTTAATCGTGGTGAAAAACTAGGTGTTTTGAAGGTTTATTTTGAACACAATCTTGACAAGATGGCACGCTTTTTCGAAGCACGTTTTAAGGAAAAAAGCAGCAGGATTGAACAGGTGGTTCAAGCAGCTTTAAAAAAGAAAATTTTACCCGCTATGGAACGACGTATTCGAGCGGAACTCACTGAGGAAGCAGAAGATGGTGCTATTAAGTTGTTTTCTGACAATCTCAGAAATCTGCTTATGATTCCGCCCTTAAAAGGTAAAGTGGTACTTGGCTTTGACCCTGCTTTTCGTACAGGAGCCAAGCTGGCTGTTGTTGATCAGACAGGTAAGCTGATTATGACTCAGGTTATTTATCCTGTGCCTCCAGCTAGTCAGTCCAAGATTAATCAGGCTAAAAGCGAACTTGCAGAACTTATTAAGAGATATGCCATTGAAATAATTGCTATTGGCAATGGTACTGCCAGTCGTGAGAGTGAAGCTTTTGTTGCAGAGATTTTAAAGGATTTCCCACAAGTTTCTTATGTGCTTGTCAATGAAAGCGGAGCCTCTGTCTATTCTGCATCGGAGTTAGCTCGTCACGAATTTCCTGACTTAAGTGTGGAAAAACGTTCTGCTATTTCCATTGCTAGGCGTTTGCAAGACCCTTTGGCAGAATTGGTTAAGATTGATCCTAAATCTATTGGTGTCGGTCAGTATCAACATGATGTTGGTCAGAAAAAGTTAGCTGAAAATCTTGATTTTGTCGTTGAAACAGTTGTTAATCAGGTTGGTGTTAATGTTAATACAGCCAGTCCTGCCCTTCTTTCTCATGTTTCAGGACTGAATAAAACGATCTCAGAAAATATTGTCAAGTACCGTGAAGAAAAAGGCAAAATTCAGTCGCGTCAAGAAATTAAAGAGGTACCTCGTTTAGGGGATAAGGCTTTTGAACAGGCGGCTGGCTTCTTAAGAATCCCGAATGCAAAGAATATTTTAGATAATACAGGTGTTCACCCAGAGTCTTACGCAGCTGTTGAAAAACTCTTTGCTCTTTTGGAAATAACGGAATTGGATGAATCAGCTCGATCAAAATTACGATCAGTAGCAATTGAAAAAGTAGCTACTGAAGTTAACCTTGGACAGGAAACTCTAAAGGATATTATTGCTGATTTGCTAAAACCAGGCCGTGATTTACGAGATGATTTTGCAGCACCCCAATTACGTCAGGATGTTCTTGAATTGTCTGACCTTAAAATTGGACAGCAGTTAGAAGGAACTATTCGTAATGTTGTTGATTTTGGTGCCTTTGTGGATATTGGTCTTCATGAAGATGGTTTGATACATATCTCACAAATGAGCAAAAATTTTGTCAAGCATCCCAGCCAAATTGTAGCCGTTGGGGATGTTGTTACTGTCTGGGTTTCAAAAATTGATATAGAACGGGGGAAAGTTAATCTTTCTTTGGTGGCCTTAAATGAATTTAACTGA","5.90","-6.73","79111","MEIIEKIAEDLHLKESQIQKVLDLAAQGNTIPFIARYRKEMTGNLDEVEIKSIIDLDKNLTALAERKATVLAKIEGQGKLTAELQEAIEAASKLADVEELYLPYKEKRRTKATIARENGLFPLARLILQNVSDLEKQAETFVNKTFPTAEKALTGAIDILIEALSDDTKLRSWTYNEIWTNSFILSKVKDQELDEKKVFQIYYDFSEKVAKIQDYRVLALNRGEKLGVLKVYFEHNLDKMARFFEARFKEKSSRIEQVVQAALKKKILPAMERRIRAELTEEAEDGAIKLFSDNLRNLLMIPPLKGKVVLGFDPAFRTGAKLAVVDQTGKLIMTQVIYPVPPASQSKINQAKSELAELIKRYAIEIIAIGNGTASRESEAFVAEILKDFPQVSYVLVNESGASVYSASELARHEFPDLSVEKRSAISIARRLQDPLAELVKIDPKSIGVGQYQHDVGQKKLAENLDFVVETVVNQVGVNVNTASPALLSHVSGLNKTISENIVKYREEKGKIQSRQEIKEVPRLGDKAFEQAAGFLRIPNAKNILDNTGVHPESYAAVEKLFALLEITELDESARSKLRSVAIEKVATEVNLGQETLKDIIADLLKPGRDLRDDFAAPQLRQDVLELSDLKIGQQLEGTIRNVVDFGAFVDIGLHEDGLIHISQMSKNFVKHPSQIVAVGDVVTVWVSKIDIERGKVNLSLVALNEFN","706077","","conserved hypothetical protein (possible transcriptional regulator)","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins/ transcriptional accessory protein: residues 7-702 are 73% similar to the conserved hypothetical protein in S.pyogenes (gi15674668).Residues 5-706 are 72% similar to transcriptional accessory protein from S.pneumoniae (gi15902852).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0732 (0.0).","

InterPro
IPR003029
Domain

RNA binding S1
PF00575	$\"[629-702]T$	S1
SM00316	$\"[631-702]T$	S1
PS50126	$\"[633-702]T$	S1

InterPro
IPR006641
Domain

Resolvase, RNase H-like fold
SM00732	$\"[307-406]T$	YqgFc

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[306-438]T$	RNaseH_fold

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[633-705]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
PTHR10724	$\"[1-706]T$	PTHR10724
SSF50249	$\"[620-701]T$	Nucleic_acid_OB

","BeTs to 3 clades of COG2183COG name: Predicted RNA binding protein, contains S1 domainFunctional Class: RThe phylogenetic pattern of COG2183 is --------eb-h-----l---Number of proteins in this genome belonging to this COG is 1","***** PR00681 (Ribosomal protein S1 signature) with a combined E-value of 9.5e-08. PR00681H 646-665 PR00681I 685-703 PR00681D 636-652***** IPB003029 (S1 RNA binding domain) with a combined E-value of 5.1e-06. IPB003029A 638-649 IPB003029B 680-691","Residues 525-636 are 31% similar to a (FLJ10379 NT2RM2002014 FIS CDNA) protein domain (PD301170) which is seen in Q9NW11_HUMAN.Residues 638-702 are 64% similar to a (RIBOSOMAL COMPLETE PROTEOME RNA-BINDING 30S REPEAT) protein domain (PD000709) which is seen in Q9CIS1_LACLA.Residues 482-538 are 71% similar to a (PROTEOME COMPLETE COMPETENCE DNA) protein domain (PD006092) which is seen in Q9CIS1_LACLA.Residues 199-467 are 68% similar to a (COMPLETE PROTEOME RNA-BINDING YDCI) protein domain (PD011817) which is seen in Q9CIS1_LACLA.Residues 138-643 are 22% similar to a (SPT6 EMB-5 NUCLEAR TRANSCRIPTION) protein domain (PD142464) which is seen in Q93148_CAEBR.Residues 583-636 are 68% similar to a (PROTEOME COMPLETE RNA-BINDING TEX) protein domain (PD015647) which is seen in Q9CIS1_LACLA.Residues 637-701 are 63% similar to a (PROTEOME COMPLETE RNA-BINDING) protein domain (PD337374) which is seen in O31489_BACSU.Residues 7-182 are 65% similar to a (PROTEOME COMPLETE RNA-BINDING TEX) protein domain (PD361497) which is seen in Q9CIS1_LACLA.Residues 482-633 are 40% similar to a (PROTEOME UU029 COMPLETE) protein domain (PD267488) which is seen in Q9PRB6_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 09:39:52 2002","Thu Jul 27 11:36:05 2006","Thu Jul 27 11:36:05 2006","Mon Dec 17 13:28:15 2001","Mon Dec 17 13:28:15 2001","Mon Dec 17 13:28:15 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0682 is paralogously related (blast p-value < 1e-3) to SMu1097, a predicted 30S ribosomal s1 protein, SMu0138,a predicted polyribonucleotide nucleotidyltransferase (PNPase) (alpha chain); SMu0567,a predicted competence protein, and SMu0443,a predicted polynucleotide nucleotidyltransferase.","Tue Mar 19 15:21:52 2002","","No significant hits to the NCBI PDB database.","SMU.751","","Residues 629 to 702 (E-value = 9.8e-18) place SMu0682 in the S1 family which is described as S1 RNA binding domain (PF00575)","Mon Dec 17 13:28:15 2001","24379213","","","","","","1","","","SMU.751","76" "SMu0683","706065","706502","438","ATGAATTTAACTGATTATGTAAAAGAGGTTTCTCGTCAAGATTTCGGTATAGAGTTCCAACATACTGCTTCTTGGAATTCACGTCTACAAACAACAGGCGGACGCTTTTTCCCCGAAGATGGACATTTGGATTTTAATCCTAAATTCTGCAAAAAGGGTGATGCAGGAACTTTTCGAAAAATTGTTCGTCATGAACTTTGTCATTACCATCTCTATTATGCAGGTAAAGGTTATCGACATGGCGATAAGGATTTTAAAGATTTGTTGCTGCAAGTCAATGGAGTGCGTTATGCACCAAGTATACAAAGCAATACTTTTTATCACTATTACCAATGTGAATCGTGTGGTCAAGTTTATCAAAGAAAAAGACGAATGAATACGAAAAAATACGCTTGTGGCAACTGCCATGGAAAATTAAGACATCAAAATCAGTCGTAA","10.10","11.86","17098","MNLTDYVKEVSRQDFGIEFQHTASWNSRLQTTGGRFFPEDGHLDFNPKFCKKGDAGTFRKIVRHELCHYHLYYAGKGYRHGDKDFKDLLLQVNGVRYAPSIQSNTFYHYYQCESCGQVYQRKRRMNTKKYACGNCHGKLRHQNQS","706501","","conserved hypothetical protein","Cytoplasm, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-145 are 64% similar to the protein in S.pyogenes (gi|15674669|). Residues 1-144 are 60% similar to the protein from S.pneumoniae (gi|15902853|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0733 (1e-52).","

InterPro
IPR005622
Family

Protein of unknown function DUF335, SprT
PF03926	$\"[1-142]T$	DUF335

InterPro
IPR006640
Family

Protein of unknown function SprT
SM00731	$\"[1-142]T$	SprT

noIPR
unintegrated

unintegrated
SSF48695	$\"[67-138]T$	SSF48695

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-139 are 55% similar to a (PROTEOME COMPLETE YDCK BH0532) protein domain (PD090558) which is seen in Q9CIS0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 09:40:14 2002","Mon Dec 17 14:34:26 2001","Thu Jan 24 09:40:14 2002","Mon Dec 17 14:34:26 2001","","Mon Dec 17 14:34:26 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0683 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 09:40:14 2002","","No significant hits to the NCBI PDB database.","SMU.752","","Residues 1 to 142 (E-value = 2.3e-57) place SMu0683 in the DUF335 family which is described as Putative metallopeptidase (SprT family) (PF03926)","Mon Dec 17 14:34:26 2001","24379214","","","","","","1","","","SMU.752","782" "SMu0684","706590","706889","300","ATGTCTAAAGCCACTTTTTATAAGAAAAGAAAAGGTAGTATGATCTGCGGAGTTGTGGCAGGACTGTCGGATAAGTATGGTTGGGAATTGCCTTTAGCTAGAATTTTAGCAGCTCTTTTTATGTATATTTTTCCGGGAGCTATTATTCTCTATATCATCTTAGCAGTCTGTTTACCTTACAAAGAGGATCTCGAAAAAGATAATCAGCAAAGGACTTATTATCGTCATGCTCAAGGGCCGCGTAAACGAAAAGATGCTGAAGTCATTGATGAAGAAGATGATAACAAATGGTTTTGGTAA","9.20","3.13","11594","MSKATFYKKRKGSMICGVVAGLSDKYGWELPLARILAALFMYIFPGAIILYIILAVCLPYKEDLEKDNQQRTYYRHAQGPRKRKDAEVIDEEDDNKWFW","706888","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 6-99 are 54% similar to the protein in S.pyogenes (gi|15674670|) and are 45% similar to the protein from S.pneumoniae (gi|15902854|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0734 (4e-26).","

InterPro
IPR007168
Domain

PspC
PF04024	$\"[3-63]T$	PspC

InterPro
IPR003755
Family

HPr(Ser) kinase
TIGR00679	$\"[1-304]T$	hpr-ser

InterPro
IPR011104
Domain

HPr Serine kinase, C-terminal
PF07475	$\"[129-309]T$	Hpr_kinase_C

InterPro
IPR011126
Domain

HPr Serine kinase, N-terminal
PF02603	$\"[1-128]T$	Hpr_kinase_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.1390.20	$\"[2-131]T$	G3DSA:3.40.1390.20
G3DSA:3.40.50.300	$\"[133-310]T$	G3DSA:3.40.50.300
SSF53795	$\"[132-307]T$	SSF53795
SSF75138	$\"[2-131]T$	SSF75138

","BeTs to 3 clades of COG1493COG name: Serine kinase of the HPr protein, regulates carbohydrate metabolismFunctional Class: TThe phylogenetic pattern of COG1493 is ---------b----gp-l---Number of proteins in this genome belonging to this COG is 1","***** IPB003755 (HPr(Ser) kinase) with a combined E-value of 2.8e-143. IPB003755A 28-56 IPB003755B 84-123 IPB003755C 137-181 IPB003755D 199-236 IPB003755E 263-295","Residues 5-295 are identical to a (KINASE KINASE/PHOSPHATASE HPRSER) protein domain (PD024452) which is seen in HPRK_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 13:26:52 2006","Fri Sep 8 13:26:08 2006","Fri Sep 8 13:26:08 2006","Mon Dec 17 14:39:54 2001","Mon Dec 17 14:39:54 2001","Mon Dec 17 14:39:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0685 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 17 14:43:32 2001","","No significant hits to the NCBI PDB database.","SMU.754","","Residues 1 to 309 (E-value = 4.5e-112) place SMu0685 in the Hpr_kinase family which is described as HPr Serine kinase (PF02603)","Mon Dec 17 14:39:54 2001","24379216","","","Brochu,D. and Vadeboncoeur,C.The HPr(Ser) kinase of Streptococcus salivarius: purification,properties, and cloning of the hprK geneJ. Bacteriol. 181 (3), 709-717 (1999)PubMed: 9922231Kravanja,M., Engelmann,R., Dossonnet,V., Bluggel,M., Meyer,H.E.,Frank,R., Galinier,A., Deutscher,J.,Schnell,N. and Hengstenberg,W.The hprK gene of Enterococcus faecalis encodes a novel bifunctional enzyme: the HPr kinase/phosphataseMol. Microbiol. 31 (1), 59-66 (1999)PubMed: 9987110","Fri Sep 8 13:26:08 2006","Mon Dec 17 14:47:19 2001","1","","","SMU.754","314" "SMu0686","708015","708794","780","ATGATTAATCCGATTGCGATAAAGTTAGGTCCTCTGGCCATACGCTGGTATTCCATCTGTATTGTAACTGGCTTAATTCTTGCTGTTTACCTAACTATACGTGAGGCACCGAAAAAGAACATTAAGTCAGATGATGTTTTAGATTTCATTTTAATTGCTTTTCCTTTAGCCATTGTCGGTGCACGACTTTATTATGTTATTTTTGACTGGGATTATTATCTTAAAAATCCTAGTGAAATACCTGTCATTTGGCATGGGGGGATCGCTATCTATGGAGGATTGCTCACAGGAGCACTCGTTTTATTCATCTTTTCCTATTATAGGATGATTAAGCCTATTGACTTTTTAGATGTTGCTACTCCAGGTGTGATGTTAGCTCAATCTATCGGTCGATGGGGAAATTTTGTCAATCAAGAAGCTTATGGTAAAGCCGTTACTCAGTTAAATTATCTGCCTGATTTTATCAGAAAACAGATGTATATTGATGGTCACTACCGTACACCAACCTTTCTTTATGAGTCTCTTTGGAATTTACTGGGTTTTATCATCATTATGATTTTACGTCGTAGACCAAATCTTTTAAAAGAAGGAGAGGTGGCTTTCTTTTATCTTATCTGGTACGGTAGTGGTCGCTTTGTTATTGAAGGCATGCGGACAGACAGTCTCATGTTTGCAAGCTTGCGGGTATCTCAGTGGCTTTCCGTTTTACTAGTGGTTGTTGGAGTTATTTTAATTGTTATAAGACGTCGTAATCATGCTATCCCCTATTACCAATGCTAG","10.20","8.62","29835","MINPIAIKLGPLAIRWYSICIVTGLILAVYLTIREAPKKNIKSDDVLDFILIAFPLAIVGARLYYVIFDWDYYLKNPSEIPVIWHGGIAIYGGLLTGALVLFIFSYYRMIKPIDFLDVATPGVMLAQSIGRWGNFVNQEAYGKAVTQLNYLPDFIRKQMYIDGHYRTPTFLYESLWNLLGFIIIMILRRRPNLLKEGEVAFFYLIWYGSGRFVIEGMRTDSLMFASLRVSQWLSVLLVVVGVILIVIRRRNHAIPYYQC","708793"," This enzyme transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins [gi:6226641]","prolipoprotein diacylglyceryl transferase","Membrane, Cytoplasm","Matches in gapped BLAST to prolipoprotein diacylglyceryl transferase: residues 1-259 are 89% similar to the previously published enzyme in S.mutans (gi6226641).Residues 1-224 are 72% similar to the protein from S.pyogenes (gi15674672) and are 70% similar to the protein from S.pneumoniae (gi15903312). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0737 (1e-103).","

InterPro
IPR001640
Family

Prolipoprotein diacylglyceryl transferase
PF01790	$\"[2-251]T$	LGT
TIGR00544	$\"[1-258]T$	lgt
PS01311	$\"[130-142]T$	LGT

","BeTs to 12 clades of COG0682COG name: Prolipoprotein diacylglyceryltransferaseFunctional Class: MThe phylogenetic pattern of COG0682 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001640 (Prolipoprotein diacylglyceryl transferase) with a combined E-value of 3.1e-38. IPB001640A 10-24 IPB001640B 86-96 IPB001640C 117-142 IPB001640D 166-184","Residues 2-225 are 98% similar to a (TRANSFERASE PROLIPOPROTEIN DIACYLGLYCERYL) protein domain (PD005412) which is seen in LGT_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 10:02:58 2002","Mon Dec 17 14:51:40 2001","Thu Sep 28 11:00:38 2006","Mon Dec 17 14:50:58 2001","Mon Dec 17 14:50:58 2001","Mon Dec 17 14:50:58 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0686 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 17 14:51:40 2001","","No significant hits to the NCBI PDB database.","SMU.755","","Residues 2 to 251 (E-value = 1.1e-135) place SMu0686 in the LGT family which is described as Prolipoprotein diacylglyceryl transferase (PF01790)","Mon Dec 17 14:50:58 2001","24379217","","","Qi,H.Y., Sankaran,K., Gan,K. and Wu,H.C.Structure-function relationship of bacterial prolipoproteindiacylglyceryl transferase: functionally significant conservedregionsJ. Bacteriol. 177 (23), 6820-6824 (1995)PubMed: 7592473","Thu Sep 28 11:00:38 2006","Mon Dec 17 14:55:31 2001","1","","","SMU.755","315" "SMu0687","708823","709218","396","ATGTGGGAAATTGCTTTATTAATTGTTGCTATTGCCTTTGCTGTTCTGGTTATTTATTTGATTCTTTTATTAAGGAAAATTTCAGATACTGTTGATGAATCGCGTCAGACTCTTAAAATTTTAACCAGTGATGTTAATGTAACGCTTTACCAAACGAATGAACTCTTGGCTAAGGCTAATGTCTTGGTTGAAGATGTTAACGGCAAGGTAGAAACTATTGATCCTCTTTTTACAGCTATCGCTGATTTATCAGTAAGTGTGTCTGATCTCAATCGGCAGGCTCGTTATTTTGGAAAGAAAACTCGTAAATCTACTGCTAATGTAGGAAAGGCAGGAGCTGCTTATACTTTTGGAAAAGTAGCGTCTAAATTATTTCGTAAGAAAGGAAAACAATAA","10.60","6.99","14431","MWEIALLIVAIAFAVLVIYLILLLRKISDTVDESRQTLKILTSDVNVTLYQTNELLAKANVLVEDVNGKVETIDPLFTAIADLSVSVSDLNRQARYFGKKTRKSTANVGKAGAAYTFGKVASKLFRKKGKQ","709217","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical protein 1:residues 1-131are 83% similar to the previously published enzyme in S.mutans(gi|7474173|).Residues 25-127 are 54% similar to the protein in S.pyogenes (gi|15674673|).Residues 26-130 are 48% similar to the protein in Lactococcus lactis (gi|15672602|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0738 (3e-39).","

InterPro
IPR009293
Family

Protein of unknown function DUF948, bacterial
PF06103	$\"[4-93]T$	DUF948

noIPR
unintegrated

unintegrated
PD029951	$\"[25-100]T$	PD029951

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-130 are 83% similar to a (PROTEOME TMNM RELATED YGAI) protein domain (PD105636) which is seen in Q9ZA55_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 10:09:22 2002","Fri Apr 26 11:01:29 2002","Thu Jan 24 10:09:22 2002","Mon Dec 17 14:58:09 2001","","Mon Dec 17 14:58:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0687 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 17 14:58:51 2001","","No significant hits to the NCBI PDB database.","SMU.756","","Residues 4 to 93 (E-value = 2.6e-50) place SMu0687 in the DUF948 family which is described as Bacterial protein of unknown function (DUF948) (PF06103)","Mon Dec 17 14:58:09 2001","24379218","","","","Thu Jan 24 10:09:22 2002","","1","","","SMU.756","912" "SMu0688","709218","709673","456","ATGAGTAAATTTTTGAAAACAGCTATTATCGGAGCGGTATCAGGAGCTGCTGCAGCTTATTTTCTCTCAACAGATAAGGGAAAACAGTTTAAGAAGAAGATCCATCAAACTTTTACGGATTACAAAGAGAACCCTAAAGAATATCATCAATACGCTGCCGATAAGGTGAATGAATACAAAGATGTAGCCGTTCATTCCTTTAAAGATTATAAGGACAAATTTGAAACAGGTGAGTTAACAAAAGACAATATTATTTCTAGTGTTAAAGAAAAGGCTTCTCAAGCAGGAAAGTTTGCTAATAGCAAATTGTCTCAAGTGAAAGATCATTTAGCACAAACAGTCGAAAAAGCAGAGGCAAGTACTAATGATGCTGTTATTCCTCTTGGAGAAATGAAGGCTCAAGTAGATGATATCGTTATTGATTATCAAGCAGAAGAAAAAACTAAAAAAGATTAA","8.90","1.96","16874","MSKFLKTAIIGAVSGAAAAYFLSTDKGKQFKKKIHQTFTDYKENPKEYHQYAADKVNEYKDVAVHSFKDYKDKFETGELTKDNIISSVKEKASQAGKFANSKLSQVKDHLAQTVEKAEASTNDAVIPLGEMKAQVDDIVIDYQAEEKTKKD","709672","","conserved hypothetical protein","Periplasm, Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical protein:residues 1-151are 91% similar to the previously published protein in S.mutans(gi7474174). Residues 1-151 are 32% similar to the protein from S.pyogenes (gi15674674).This sequence is similar to sequences from S. thermophilus (Str0669) and S.agalactiae (Sag0739).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0739 (1e-29).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-18]?$	signal-peptide
tmhmm	$\"[4-24]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 20-151 are 99% similar to a (DOMAIN OF UNKNO N) protein domain (PD202024) which is seen in Q9ZA54_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 10:12:00 2002","Tue Sep 12 12:57:35 2006","Tue Sep 12 12:57:35 2006","Mon Dec 17 15:00:31 2001","","Mon Dec 17 15:00:31 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0688 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 10:10:23 2002","","No significant hits to the NCBI PDB database.","SMU.757","","No significant hits to the Pfam 11.0 database","Mon Dec 17 15:00:31 2001","24379219","","","","Tue Sep 12 12:57:35 2006","","1","","","SMU.757","913" "SMu0689","710058","709771","288","ATGTCAGCAAATCTGAATAGGCAGACAGAAGACTTTGAAGATCTTAATTTTCAAGAAGAATCAATGCCTAAGTATCAAGAATTTCAAGATTTTGATGATAATAGAACAAAGCTAGATGAACTCATCTTTTTTGCTAAATTAGCTTTTTTCTGCGTAACGACTATTCTAGTGTGTTTCATTCTATTAGTCGCTAAGTTTTCTCCAATTTTTGCTTTTCCACTAGCTATGCTGATTAGCTGGGGAATCACAGCTTTAGCTCAAAAAGGATTAAAACGGCTTAAACATTAA","5.10","-1.87","11057","MSANLNRQTEDFEDLNFQEESMPKYQEFQDFDDNRTKLDELIFFAKLAFFCVTTILVCFILLVAKFSPIFAFPLAMLISWGITALAQKGLKRLKH","709776","","conserved hypothetical protein","Cytoplasm, Membrane","Limited matches in gapped BLAST to hypothetical proteins: residues 1-93 are 43% similar to the protein in S.pyogenes (gi|15674675|). Residues 7-92 are 29% similar to the protein from S.pneumoniae (gi|15900693|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0740 (2e-14).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[41-63]?$ $\"[69-89]?$	transmembrane_regions

InterPro
IPR001539
Family

Peptidase U32
PD004398	$\"[89-280]T$	Peptidase_U32
PF01136	$\"[74-306]T$	Peptidase_U32

noIPR
unintegrated

unintegrated
SSF51621	$\"[9-101]T$	SSF51621

","BeTs to 5 clades of COG0826COG name: Protease related to collagenaseFunctional Class: OThe phylogenetic pattern of COG0826 is -MT--q--EB-huj-------Number of proteins in this genome belonging to this COG is 2","***** IPB001539 (Peptidase family U32) with a combined E-value of 9.3e-16. IPB001539A 5-30 IPB001539B 156-196 IPB001539C 278-303","Residues 6-300 are 58% similar to a (PROTEASE PROTEOME COMPLETE COLLAGENASE) protein domain (PD004398) which is seen in Q9CE56_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 09:51:46 2002","Fri Sep 8 13:33:01 2006","Fri Sep 8 13:33:01 2006","Mon Dec 17 15:06:24 2001","Mon Dec 17 15:06:24 2001","Mon Dec 17 15:06:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0690 is paralogously related (blast p-value < 1e-3) to SMu0691, a predicted protease; related to collagenase.","Thu Jan 24 10:13:23 2002","","No significant hits to the NCBI PDB database.","SMU.759","","Residues 74 to 306 (E-value = 4.6e-76) place SMu0690 in the Peptidase_U32 family which is described as Peptidase family U32 (PF01136)","Mon Dec 17 15:06:24 2001","24379221","","","","","","1","","","SMU.759","316" "SMu0691","711496","712782","1287","ATGACAAAACAATTAAAACGCCCAGAAGTGCTATCGCCTGCTGGGACTTTAGAAAAATTAAAAGTTGCTGTTAACTATGGAGCAGATGCTGTTTTTGTTGGCGGACAAGCTTATGGTTTGCGCAGTCGTGCAGGTAACTTTTCGATGGAAGAAATGGCTGAAGGAATTAATTATGCTCATGATCATGGGGTCAAGGTTTATGTGGCTGCTAACATGGTAACTCATGAGGGCAATGAAATAGGAGCCGGTGCATGGTTTCGTGAATTACGCGACTTAGGTCTAGATGCAGTTATTGTATCGGATCCAGCCCTTATTGCGATTTGTGCGACAGATGCACCTGGTTTGGAAATTCATTTGTCAACTCAAGCTTCATCCACTAACTATGAAACCTTTGAATTTTGGAAAGAACTGGGCTTGACACGTGTTGTTTTAGCGCGTGAAGTCACAATGGCAGAACTAGCTGAGATTCGTAAGCGTACGAGTGTTGAAATTGAAGCCTTTGTTCATGGGGCAATGTGTATTTCTTATTCAGGACGCTGTGTACTTTCCAATCATATGAGTCATCGCGATGCTAATCGTGGTGGTTGTTCACAATCTTGTCGTTGGAAATACAATCTTTATGATATGCCTTTCGGTCAAGAAAGACGGTCATTGAAAGGTGAAGTACCAGAGGAATTTTCAATGTCAGCTGTTGATATGTGCATGATTGAAAATATTCCAGACATGATTGAAAATGGTGTTGATAGCCTTAAAATTGAAGGACGTATGAAGTCTATTCACTATGTTTCGACGGTCACAAATTGTTACAAGGCGGCTGTCAATGCCTATCTGGAAAGCCCTCAAGCATTTGAAGCTATCAAACAAGATTTGATTGACGAATTGTGGAAAGTCGCTCAGCGTGAATTGGCTACAGGTTTCTATTACCAAACACCTACTGAAAATGAACAGCTTTTTGGAGCTCGTCGTAAAATTCCCCAATATAAATTTGTCGGTGAAGTGGTTGATTTTGATGAGCCAAGTATGACAGCAACTATTCGTCAGCGTAATGTCATTAATGAGGGGGATCGGGTTGAATTCTACGGACCTGGTTTCCGTCATTTTGAAACCTTTATTACAGATTTACATGATGCGGATGGTCAAAAAATTGAACGTGCGCCAAAACCGATGGAGTTATTGACAATTACGGTACCACAGGAAGTCAAAGCAGGTGATATGATTCGTGCCTGCAAGGAAGGCTTGGTCAATCTTTACAAAGAAGATGGCAGCAGCCTTACTGTTAGAACTTAA","5.30","-11.92","47896","MTKQLKRPEVLSPAGTLEKLKVAVNYGADAVFVGGQAYGLRSRAGNFSMEEMAEGINYAHDHGVKVYVAANMVTHEGNEIGAGAWFRELRDLGLDAVIVSDPALIAICATDAPGLEIHLSTQASSTNYETFEFWKELGLTRVVLAREVTMAELAEIRKRTSVEIEAFVHGAMCISYSGRCVLSNHMSHRDANRGGCSQSCRWKYNLYDMPFGQERRSLKGEVPEEFSMSAVDMCMIENIPDMIENGVDSLKIEGRMKSIHYVSTVTNCYKAAVNAYLESPQAFEAIKQDLIDELWKVAQRELATGFYYQTPTENEQLFGARRKIPQYKFVGEVVDFDEPSMTATIRQRNVINEGDRVEFYGPGFRHFETFITDLHDADGQKIERAPKPMELLTITVPQEVKAGDMIRACKEGLVNLYKEDGSSLTVRT","712781","","protease; related to collagenase","Cytoplasm","Several matches in gapped BLAST to proteases: residues 1-428 are 86% similar to the enzyme in S.pyogenes (gi|15674677|). Residues 1-427 are 83% similar to the protein from S.pneumoniae (gi|15901282|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0742 (0.0).","

InterPro
IPR001539
Family

Peptidase U32
PD004398	$\"[95-270]T$	Peptidase_U32
PF01136	$\"[79-313]T$	Peptidase_U32
PS01276	$\"[165-183]?$	PEPTIDASE_U32

noIPR
unintegrated

unintegrated
SSF51412	$\"[9-152]T$	SSF51412

","BeTs to 6 clades of COG0826COG name: Protease related to collagenaseFunctional Class: OThe phylogenetic pattern of COG0826 is -MT--q--EB-huj-------Number of proteins in this genome belonging to this COG is 2","***** IPB001539 (Peptidase family U32) with a combined E-value of 4.2e-56. IPB001539A 9-34 IPB001539B 161-201 IPB001539C 249-274","Residues 310-407 are 70% similar to a (PROTEOME COMPLETE PROTEASE YRRO) protein domain (PD130207) which is seen in Q9CE58_LACLA.Residues 255-307 are 47% similar to a (PROTEOME COMPLETE YRRO PROTEASE) protein domain (PD411612) which is seen in Q9KDD9_BACHD.Residues 10-191 are 24% similar to a (PROTEOME COMPLETE MJ1657) protein domain (PD133383) which is seen in Q59051_METJA.Residues 10-307 are 81% similar to a (PROTEASE PROTEOME COMPLETE COLLAGENASE) protein domain (PD004398) which is seen in Q9CE58_LACLA.Residues 189-287 are 35% similar to a (PROTEOME COMPLETE COLLAGENASE) protein domain (PD143977) which is seen in O27791_METTH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 09:52:11 2002","Mon Dec 17 15:49:04 2001","Sat Oct 12 09:52:11 2002","Mon Dec 17 15:49:04 2001","Mon Dec 17 15:49:04 2001","Mon Dec 17 15:49:04 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0691 is paralogously related (blast p-value < 1e-3) to SMu0690, a predicted protease; related to collagenase.","Thu Jan 24 10:14:06 2002","","No significant hits to the NCBI PDB database.","SMU.761","","Residues 79 to 313 (E-value = 2.4e-129) place SMu0691 in the Peptidase_U32 family which is described as Peptidase family U32 (PF01136)","Mon Dec 17 15:49:04 2001","24379222","","","","","","1","","","SMU.761","77" "SMu0692","712912","713472","561","ATGTCTTTAGTCGGAAAGGAAATGGTTGAATTTTCAGCCCAAGCTTATCATCAAGGAGAATTTGTTACGGTTAACAATGAGGATGTTAAAGGGAAGTGGGCAGTCTTTTGTTTCTATCCAGCGGATTTTTCTTTCGTGTGTCCTACTGAGTTAGGTGATCTTCAAGAACAATATGCAACTTTGCAATCTTTAGGTGTGGAAGTTTACTCTGTTTCAACAGATACTCATTTTGTTCACAAGGCTTGGCATGATGATTCAGATGTTGTTGGAACAATTACTTATACTATGATTGGGGATCCTTCTCATGTTCTCTCACAAGGATTTGAGGTTTTAGGTGAAGATGGTTTAGCACAACGTGGAACCTTTATTGTAGATCCGGATGGTATCATTCAAATGATGGAAGTCAATGCAGATGGTATTGGTCGTGATGCTAGTACCTTGATTGATAAAGTTCGTGCAGCTCAATATATTCGCCAACATCCAGGAGAAGTTTGCCCTGCCAAATGGAAAGAGGGAGCTGAAACTTTAAAACCAAGTTTGGATCTTGTCGGTAAAATTTAA","4.40","-13.69","20463","MSLVGKEMVEFSAQAYHQGEFVTVNNEDVKGKWAVFCFYPADFSFVCPTELGDLQEQYATLQSLGVEVYSVSTDTHFVHKAWHDDSDVVGTITYTMIGDPSHVLSQGFEVLGEDGLAQRGTFIVDPDGIIQMMEVNADGIGRDASTLIDKVRAAQYIRQHPGEVCPAKWKEGAETLKPSLDLVGKI","713471","For other 'ahp' genes see SMu0693 (ahpF).From Genbank: [gi:1703216]This enzyme directly reduces organic hydroperoxides in its reduced dithiol form.","alkyl hydroperoxide reductase, subunit C","Cytoplasm","Matches in gapped BLAST to alkyl hydroperoxidase:residues 1-186 are 100% similar to a previously published enzyme in S.mutans (gi:3062838).Residues 1-186 are 89% similar to the enzyme from S.pyogenes (gi:15675837) and are 72% similar to the enzyme from B.subtilis (gi:16081061).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1833 (1e-100).","

InterPro
IPR000866
Domain

Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen
PF00578	$\"[4-133]T$	AhpC-TSA

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[2-186]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[2-186]T$	IPR012336

noIPR
unintegrated

unintegrated
PTHR10681	$\"[1-179]T$	PTHR10681
PTHR10681:SF7	$\"[1-179]T$	PTHR10681:SF7

","BeTs to 15 clades of COG0450COG name: Thiol - alkyl hydroperoxide reductasesFunctional Class: OThe phylogenetic pattern of COG0450 is amtkYQvCeBR-uj---linxNumber of proteins in this genome belonging to this COG is 1","***** IPB000866 (AhpC/TSA family) with a combined E-value of 1.2e-17. IPB000866A 35-50 IPB000866B 68-82 IPB000866C 140-149","Residues 4-55 are identical to a (PEROXIDASE ANTIOXIDANT PEROXIREDOXIN COMPLETE PROTEOME) protein domain (PD000498) which is seen in O66265_STRMU.Residues 1-69 are 47% similar to a (C ALKYL SUBUNIT REDUCTASE) protein domain (PD388245) which is seen in O06464_XANCH.Residues 71-155 are 70% similar to a (PEROXIDASE ANTIOXIDANT PEROXIREDOXIN COMPLETE PROTEOME) protein domain (PD000721) which is seen in Q53647_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 4 15:27:44 2005","Mon Apr 4 15:27:44 2005","Mon Apr 4 15:27:44 2005","Mon Dec 17 15:55:29 2001","Mon Dec 17 15:55:29 2001","Mon Dec 17 15:55:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0692 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 17 15:57:52 2001","Thu Feb 3 14:42:52 2005","pdb1QMVA Chain A, Thioredoxin Peroxidase B From Red Blood Cel... 130 1e-031pdb1QQ2A Chain A, Crystal Structure Of A Mammalian 2-Cys Pero... 128 6e-031","SMU.764","","Residues 4 to 150 (E-value = 4.2e-57) place SMu0692 in the AhpC-TSA family which is described as AhpC/TSA family (PF00578)","Mon Dec 17 15:55:29 2001","24379223","","Poole,L.B., Higuchi,M., Shimada,M., Calzi,M.L. and Kamio,Y.Streptococcus mutans H2O2-forming NADH oxidase is an alkylhydroperoxide reductase proteinFree Radic. Biol. Med. 28 (1), 108-120 (2000)PubMed: 10656297Higuchi,M., Shimada,M., Matsumoto,J., Yamamoto,Y., Rhaman,A. andKamio,Y.Molecular cloning and sequence analysis of the gene encoding theH2O2-forming NADH oxidase from Streptococcus mutansBiosci. Biotechnol. Biochem. 58 (9), 1603-1607 (1994)PubMed: 7765479","Poole LB.Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases.Arch Biochem Biophys. 2005 Jan;433(1):240-54.PMID: 15581580Fukumori F, Kishii M.Molecular cloning and transcriptional analysis of the alkyl hydroperoxide reductase genes from Pseudomonas putida KT2442.J Gen Appl Microbiol. 2001 Oct;47(5):269-277.PMID: 12483614Rocha ER, Smith CJ.Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate Anaerobe bacteroides fragilis.J Bacteriol. 1999 Sep;181(18):5701-10.PMID: 10482511Hartford,O.M. and Dowds,B.C.Isolation and characterization of a hydrogen peroxide resistantmutant of Bacillus subtilisMicrobiology 140 (Pt 2), 297-304 (1994)PubMed: 8180695","Mon Apr 4 15:27:44 2005","Mon Apr 4 15:27:44 2005","1","","","SMU.764","" "SMu0693","713482","715014","1533","ATGGCATTAGACGCAGAAATCAAAGAGCAGTTAGGACAGTATCTTCAATTACTTGAGTCTGAGATTGTTTTACAAGCTCAATTAAAAGACGATGCTAATTCTCAAAAAGTTAAGGAATTTCTCCAAGAAATCGTTGCAATGTCTCCTATGATTTCTTTAGAAGAAAAGGAACTTCCGCGAACACCTAGTTTTCGCATAGCTAAAAAGGGACAAGAATCTGGTGTTGAATTTGCTGGCTTACCCCTTGGTCACGAATTTACTTCGTTTATCTTGGCTCTGTTACAGGTTTCAGGGCGTCCGCCTAAGGTAGAGACTGATATTGTCAAACGCATTCAAGCTGTTGATGAACCTATGCATTTTGAAACCTATGTTAGTTTGACTTGTCATAATTGTCCAGATGTTGTTCAGGCTTTCAATATCATGTCAGTTGTTAATCCCAACATTTCACATACAATGGTGGAAGGTGGCATGTTTAAAGATGAAATTGAAGCTAAGGGAATTATGTCTGTGCCAACTGTCTATAAAGATGGAACAGAATTTACCTCAGGGCGTGCTAGCATAGAGCAATTACTAGACTTGATAGCAGGTCCTCTTAAAGAAGATGCTTTTGATGATAAAGGTGTTTTTGATGTCCTTGTTATTGGTGGGGGTCCTGCTGGTAATAGCGCGGCTATCTATGCTGCAAGAAAGGGAGTTAAAACAGGACTTTTAGCTGAAACCATGGGTGGTCAAGTTATGGAAACCGTGGGTATTGAAAATATGATCGGTACCCCATATGTTGAAGGACCCCAATTAATGGCTCAGGTGGAAGAGCATACCAAGTCTTATTCTGTTGACATCATGAAGGCACCGCGTGCTAAGTCTATTCAAAAGACAGACTTGGTTGAAGTTGAACTTGATAATGGAGCTCATTTGAAAGCAAAGACAGCTGTTTTGGCCTTAGGTGCCAAGTGGCGTAAAATCAATGTACCAGGAGAAAAAGAATTCTTTAATAAAGGTGTTACTTACTGTCCGCACTGTGATGGTCCTCTTTTCACAGACAAAAAAGTCGCTGTCATTGGCGGTGGAAACTCAGGTTTAGAAGCAGCTATTGATTTGGCTGGGTTAGCTAGCCATGTCTATATTTTAGAATTTTTACCTGAGTTAAAAGCTGATAAGATCTTACAAGATCGTGCGGAAGCTCTTGATAATATTACCATTCTAACTAATGTTGCGACTAAAGAAATTATTGGCAATGACCACGTAGAAGGTCTTCGTTACAGTGATCGTACGACCAATGAAGAGTACTTGCTTGATTTAGAAGGTGTTTTTGTTCAAATTGGATTGGTACCTAGTACTGACTGGTTAAAGGATAGTGGACTAGCACTCAATGAAAAAGGTGAAATCATTGTTGCTAAAGATGGCGCAACTAATATTCCTGCTATTTTTGCAGCTGGTGATTGCACAGATAGTGCCTACAAACAAATTATCATTTCCATGGGTTCTGGAGCTACTGCGGCTTTAGGTGCCTTTGATTATTTGATTAGAAATTAA","4.60","-24.01","55137","MALDAEIKEQLGQYLQLLESEIVLQAQLKDDANSQKVKEFLQEIVAMSPMISLEEKELPRTPSFRIAKKGQESGVEFAGLPLGHEFTSFILALLQVSGRPPKVETDIVKRIQAVDEPMHFETYVSLTCHNCPDVVQAFNIMSVVNPNISHTMVEGGMFKDEIEAKGIMSVPTVYKDGTEFTSGRASIEQLLDLIAGPLKEDAFDDKGVFDVLVIGGGPAGNSAAIYAARKGVKTGLLAETMGGQVMETVGIENMIGTPYVEGPQLMAQVEEHTKSYSVDIMKAPRAKSIQKTDLVEVELDNGAHLKAKTAVLALGAKWRKINVPGEKEFFNKGVTYCPHCDGPLFTDKKVAVIGGGNSGLEAAIDLAGLASHVYILEFLPELKADKILQDRAEALDNITILTNVATKEIIGNDHVEGLRYSDRTTNEEYLLDLEGVFVQIGLVPSTDWLKDSGLALNEKGEIIVAKDGATNIPAIFAAGDCTDSAYKQIIISMGSGATAALGAFDYLIRN","715013","For other 'ahp' genes see SMu0692 (ahpC).From InterPro: IPR001327 FAD-dependent pyridine nucleotide-disulphide oxidoreductase.This entry describes both class I and class II oxidoreductases. FAD flavoproteins belonging to the family of pyridine nucleotide-disulphide oxidoreductases (glutathione reductase, trypanothione reductase, lipoamide dehydrogenase, mercuric reductase, thioredoxin reductase, alkyl hydroperoxide reductase) share sequence similarity with a number of other flavoprotein oxidoreductases, in particular with ferredoxin-NAD+ reductases involved in oxidative metabolism of a variety of hydrocarbons (rubredoxin reductase, putidaredoxin reductase, terpredoxin reductase, ferredoxin-NAD+ reductase components of benzene 1,2-dioxygenase, toluene 1,2-dioxygenase, chlorobenzene dioxygenase, biphenyl dioxygenase), NADH oxidase and NADH peroxidase. Comparison of the crystal structures of human glutathione reductase and Escherichia coli thioredoxin reductase reveals different locations of their active sites, suggesting that the enzymes diverged from an ancestral FAD/NAD(P)H reductase and acquired their disulphide reductase activities independently.","alkyl hydroperoxide reductase, subunit F","Cytoplasm","Matches in gapped BLAST to NADH oxidase/alkyl hydroperoxidase reductase: residues 1-510 are 100% similar to a previously published enzyme in S.mutans (gi:3062839).Residues 1-509 are 75% similar to the enzyme from S.pyogenes (gi:15675838) and are 63% similar to the enzyme from Thermus aquaticus (gi:8927564).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1834 (0.0).","

InterPro
IPR000103
Domain

Pyridine nucleotide-disulphide oxidoreductase, class-II
PR00469	$\"[210-232]T$ $\"[242-257]T$ $\"[262-272]T$ $\"[308-316]T$ $\"[330-342]T$ $\"[345-369]T$ $\"[397-413]T$ $\"[435-456]T$ $\"[470-488]T$	PNDRDTASEII

InterPro
IPR000759
Family

Adrenodoxin reductase
PR00419	$\"[210-232]T$ $\"[350-364]T$	ADXRDTASE

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[315-382]T$	FAD_pyr_redox
PF00070	$\"[349-441]T$	Pyr_redox

InterPro
IPR003042
Family

Aromatic-ring hydroxylase
PR00420	$\"[210-232]T$ $\"[459-474]T$	RNGMNOXGNASE

InterPro
IPR008255
Active_site

Pyridine nucleotide-disulphide oxidoreductase, class-II, active site
PS00573	$\"[337-357]T$	PYRIDINE_REDOX_2

InterPro
IPR012081
Family

Alkyl hydroperoxide reductase, subunit F
PIRSF000238	$\"[2-510]T$	AhpF

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[2-93]T$ $\"[102-196]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[2-101]T$ $\"[102-196]T$	IPR012336

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[210-232]T$ $\"[310-319]T$ $\"[349-374]T$ $\"[434-448]T$ $\"[475-482]T$	FADPNR
PF07992	$\"[210-486]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[208-318]T$ $\"[319-441]T$	G3DSA:3.50.50.60
PTHR22912	$\"[212-483]T$	PTHR22912
SSF51905	$\"[209-506]T$	SSF51905

","BeTs to 17 clades of COG0492COG name: Thioredoxin reductase/alkyl hydroperoxide reductaseFunctional Class: OThe phylogenetic pattern of COG0492 is amtkYQVcEBrhUJgpolinXNumber of proteins in this genome belonging to this COG is 3","***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 1.2e-78. IPB000103A 210-230 IPB000103B 242-256 IPB000103C 315-363 IPB000103D 435-446 IPB000103E 470-507***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 9.2e-34. PR00368A 210-232 PR00368B 310-319 PR00368C 349-374 PR00368D 434-448 PR00368E 475-482***** PR00420 (Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature) with a combined E-value of 4.5e-07. PR00420A 210-232 PR00420D 350-366***** PR00419 (Adrenodoxin reductase family signature) with a combined E-value of 7.9e-06. PR00419A 210-232 PR00419D 350-364","Residues 295-483 are 66% similar to a (OXIDOREDUCTASE FLAVOPROTEIN FAD CENTER REDOX-ACTIVE) protein domain (PD000139) which is seen in Q9KH09_THEAQ.Residues 210-480 are 21% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD132291) which is seen in Q9PHV6_CAMJE.Residues 350-403 are identical to a (OXIDOREDUCTASE THIOREDOXIN FAD) protein domain (PD345560) which is seen in Q54469_STRMU.Residues 119-180 are identical to a (REDUCTASE FLAVOPROTEIN HYDROPEROXIDE ALKYL FAD) protein domain (PD007583) which is seen in Q54469_STRMU.Residues 436-507 are 34% similar to a (PROTEOME REDUCTASE-LIKE THIOREDOXIN) protein domain (PD232972) which is seen in Q9HHD5_HALN1.Residues 283-501 are 26% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE) protein domain (PD329335) which is seen in Q9Z9W3_BACHD.Residues 3-115 are identical to a (REDUCTASE FLAVOPROTEIN ALKYL) protein domain (PD364642) which is seen in O66266_STRMU.Residues 305-345 are identical to a (REDUCTASE FLAVOPROTEIN FAD OXIDOREDUCTASE THIOREDOXIN) protein domain (PD329455) which is seen in Q54469_STRMU.Residues 404-483 are identical to a (FAD FLAVOPROTEIN OXIDOREDUCTASE NADH) protein domain (PD406982) which is seen in Q54469_STRMU.Residues 208-315 are 30% similar to a (COMPLETE PROTEOME FAD FLAVOPROTEIN) protein domain (PD348239) which is seen in O31475_BACSU.Residues 398-482 are 34% similar to a (REDUCTASE PROTEOME COMPLETE FAD) protein domain (PD294764) which is seen in O05268_BACSU.Residues 411-507 are 29% similar to a (FAD THIOREDOXIN FLAVOPROTEIN) protein domain (PD396826) which is seen in Q9K4L6_STRCO.Residues 407-507 are 29% similar to a (CENTER FAD THIOREDOXIN NADP) protein domain (PD394558) which is seen in TRXB_MYCPN.Residues 196-265 are identical to a (REDUCTASE FLAVOPROTEIN OXIDOREDUCTASE FAD THIOREDOXIN) protein domain (PD396269) which is seen in Q54469_STRMU.Residues 180-253 are 53% similar to a (F ALKYL SUBUNIT REDUCTASE) protein domain (PD001422) which is seen in AHPF_PSEPU.Residues 210-253 are 72% similar to a (OXIDOREDUCTASE FAD FLAVOPROTEIN COMPLETE PROTEOME) protein domain (PD000271) which is seen in Q9KH09_THEAQ.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 6 15:19:05 2007","Tue Mar 6 15:19:05 2007","Mon Apr 4 15:58:24 2005","Mon Dec 17 16:01:43 2001","Mon Dec 17 16:01:43 2001","Mon Dec 17 16:01:43 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0693 is paralogously related (blast p-value < 1e-3) to SMu0420, a predicted NADH oxidase, SMu0792, a predicted thioredoxin reductase, SMu1299 and SMu0116,both predicted dihydrolipoamide dehydrogenase, SMu1020, a predicted H2O-forming NADH oxidase, SMu0762 and SMu0126, both predicted glutathione reductases.","Thu Jan 24 10:24:28 2002","Thu Feb 3 14:42:21 2005","pdb1CL0A Chain A, Crystal Structure Of Reduced Thioredoxin Re... 159 6e-040pdb1TDE Thioredoxin Reductase (E.C.1.6.4.5) (Wild Type) 159 6e-040pdb1F6MA Chain A, Crystal Structure Of A Complex Between Thio... 155 8e-039","SMU.765","","Residues 210 to 491 (E-value = 1.7e-73) place SMu0693 in the Pyr_redox family which is described as Pyridine nucleotide-disulphide oxidoreductase (PF00070)","Mon Dec 17 16:01:43 2001","24379224",""," Abranches J, Lemos JA, Burne RA.,Osmotic stress responses of Streptococcus mutans UA159.FEMS Microbiol Lett. 2006 Feb;255(2):240-6.PMID: 16448501 Poole,L.B., Higuchi,M., Shimada,M., Calzi,M.L. and Kamio,Y.Streptococcus mutans H2O2-forming NADH oxidase is an alkylhydroperoxide reductase proteinFree Radic. Biol. Med. 28 (1), 108-120 (2000)PubMed: 10656297Higuchi,M., Shimada,M., Matsumoto,J., Yamamoto,Y., Rhaman,A. andKamio,Y.Molecular cloning and sequence analysis of the gene encoding theH2O2-forming NADH oxidase from Streptococcus mutansBiosci. Biotechnol. Biochem. 58 (9), 1603-1607 (1994)PubMed: 7765479","Poole LB.Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases.Arch Biochem Biophys. 2005 Jan;433(1):240-54.PMID: 15581580Ross RP, Claiborne A.Molecular cloning and analysis of the gene encoding the NADH oxidase from Streptococcus faecalis 10C1. Comparison with NADH peroxidase and the flavoprotein disulfide reductases.J Mol Biol. 1992 Oct;227(3):658-71.PMID: 1404382Kuriyan J, Krishna TS, Wong L, Guenther B, Pahler A, Williams CH, Model P.Convergent evolution of similar function in two structurally divergent enzymes.Nature. 1991 Jul;352(6331):172-4.PMID: 2067578Xu,X.M., Koyama,N., Cui,M., Yamagishi,A., Nosoh,Y. and Oshima,T.Nucleotide sequence of the gene encoding NADH dehydrogenase from an alkalophile, Bacillus sp. strain YN-1J. Biochem. 109 (5), 678-683 (1991)PubMed: 1917890Eggink G, Engel H, Vriend G, Terpstra P, Witholt B.Rubredoxin reductase of Pseudomonas oleovorans. Structural relationship to other flavoprotein oxidoreductases based on one NAD and two FAD fingerprints.J Mol Biol. 1990 Mar;212(1):135-42.PMID: 2319593Xu,X.M., Kanaya,S., Koyama,N., Sekiguchi,T., Nosoh,Y., Ohashi,S.and Tsuda,K.Tryptic digestion of NADH dehydrogenase from alkalophilic BacillusJ. Biochem. 105 (4), 626-632 (1989)PubMed: 2760020","Tue Mar 6 15:19:05 2007","Mon Apr 4 16:00:32 2005","1","","","SMU.765","" "SMu0694","715085","715603","519","ATGAAATTGACTTATGAAGATAAAGTTCTCATCTATGAACTGAAAAACCAAGGGTATAGCTTAGAGCAGCTTTCAAATAAATTTGGGATAAAAATTTCTAATCTTAGCTACATGATTAAATTGATTGATCATTACGGAATAGAGATCGTCAAAAAAGGAAAGAATCGTTACTATTCTCCTGAACTAAAACAAGAAATCATTGATAAAGTTCTTCTTGAAGGTCGTTCACAAATAAGGGTGTCTCTAGATTATGCTCTTCCAAGTCATGGAATGTTGCCTAATTGGATAGCACAATACAAGAAAAATAGGTATACTATTGTTGAGAAAACAAGAGGGAGACCACCTAAAATGGGACGTAAGCCAAAGAAGAAATCGGAAGAAATGACAGAGCTAGAGCAACTTCAGAAAGAATTAGAATATCTGAGAGCGGAGAATGCTGTTCTAAAAAAGTTGAGAGAACTCCGATTGAGGGAAGAAAAAGAGCAAGAAGAAAAACGGAAATTGTCCGAGGATTGGTAA","10.40","10.49","20606","MKLTYEDKVLIYELKNQGYSLEQLSNKFGIKISNLSYMIKLIDHYGIEIVKKGKNRYYSPELKQEIIDKVLLEGRSQIRVSLDYALPSHGMLPNWIAQYKKNRYTIVEKTRGRPPKMGRKPKKKSEEMTELEQLQKELEYLRAENAVLKKLRELRLREEKEQEEKRKLSEDW","715602","","conserved hypothetical protein, IS861 associated","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and IS861 associated segments: residues 1-108 are 73% similar to the protein in S.pneumoniae (gi|8163692|) and are 62% similar to the protein in S.pyogenes (gi|15674401|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1526 (9e-37).","

InterPro
IPR002514
Family

Transposase IS3/IS911
PF01527	$\"[55-148]T$	Transposase_8

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[3-96]T$	Homeodomain_like

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 38-108 are 67% similar to a (DOMAIN OF UNKNO N) protein domain (PD354820) which is seen in Q53639_STRAG.Residues 1-37 are 78% similar to a (DOMAIN OF UNKNO N) protein domain (PD230559) which is seen in Q9KK22_STRPN.","","Thu Nov 29 18:33:30 2001","Thu Nov 29 18:33:30 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 22 12:39:16 2002","Fri Jan 3 15:32:43 2003","Fri Jan 3 15:32:43 2003","Mon Dec 17 16:12:08 2001","","Mon Dec 17 16:12:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0694 is paralogously related (blast p-value < 1e-3) to SMu1720, SMu1284, SMu1257, SMu0515, and SMu0396, all predicted conserved hypotheticals,possibly transposon IS861 associated.","Tue Jan 22 12:38:53 2002","","No significant hits to the NCBI PDB database.","SMU.766","Thu Nov 29 18:33:30 2001","Residues 55 to 148 (E-value = 5.3e-06) place SMu0694 in the Transposase_8 family which is described as Transposase (PF01527)","Mon Dec 17 16:12:08 2001","24379225","","","","","","1","","","SMU.766","" "SMu0695","715597","716433","837","TTGGTAACGGAGTTTTCTTTAGACATTCTTCTAAAGATTATTAAGCTCGCTCGTTCAACCTATTATTACCACTTAAAGCAGCTAGATAAAAGCAATAAAGATCATGCTATTAAAGCTGAAATTCAAGCTATTTTTACTGAGCACAAAGGAAATTATGGTTATCGTCGAATGACTCTTGAATTGAGAAATCGTGGCTTCTTGGTAAATCATAAAAAGGTTCAACGTCTAATGAAAGTTCTTGGTTTGGAGGCTCGTATTCGTCGCAAACGGAAGTATTCTTCCTACCAAGGAGAGGTGGGCAAGAAAGCAGACAACCTTATTCAACGCCAATTTGAAGCATCAAAACCAATGGAAAAGTGCTACACAGATGTGACAGAATTTGCCATTCCAGCAAGCGGTCAAAAGCTCTATTTGTCACCAGTTTTAGATGGTTTCAACAGTGAAATTATTGCTTATAACCTTTCTACGTCACCGAACTTGATACAAGTGAAAGCTATGCTAGAACAGGCTTTCACAGAGAAACATTACACAAATACTATTCTTCATAGTGACCAAGGCTGGCAATACCAGCATGATTTTTATCATCAATTTTTAGAGAACAAGGGGATTCAGCCGTCCATGTCACGTAAAGGAAACAGCCCAGATAATGGCATGATGGAATCTTTCTTTGGCATTTTGAAATCCGAAATGTTTTACGGTTATGAGAAGACATTTAAGTCACTTAAGCAATTGGAACAAGCTATTGTAGACTATATTGATTATTACAACAACAAACGTATTAAGGTAAAACTAAAAGGACTTAGTCCTGTACAGTACAGAACGAAATCCTTTACTTAA","10.40","17.88","32568","MVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGNYGYRRMTLELRNRGFLVNHKKVQRLMKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQFEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIAYNLSTSPNLIQVKAMLEQAFTEKHYTNTILHSDQGWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT","716432","","transposase, IS861","Cytoplasm","Matches in gapped BLAST to IS3-Spn1 putative transposase:residues 2-277 are 84% similar to the previously published enzyme in S.mutans (gi|8163693|). Residues 2-277 are 84% similar to the enzyme in S.pneumoniae (gi|8163693|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (1e-122).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[112-274]T$	rve
PS50994	$\"[112-277]T$	INTEGRASE

noIPR
unintegrated

unintegrated
PD688335	$\"[35-76]T$	Q8DVC7_STRMU_Q8DVC7;
G3DSA:3.30.420.10	$\"[137-278]T$	no description
signalp	$\"[1-19]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 231-273 are 51% similar to a (ELEMENT ORFB B. CRYIIB) protein domain (PD410106) which is seen in Q57057_BACAN.Residues 163-203 are 82% similar to a (TRANSPOSASE ELEMENT COMPLETE) protein domain (PD335900) which is seen in Q9KK23_STRPN.Residues 122-162 are 95% similar to a (TRANSPOSASE ELEMENT INSERTION COMPLETE) protein domain (PD006527) which is seen in Q9KK23_STRPN.Residues 12-150 are 27% similar to a (TRANSPOSASE) protein domain (PD102854) which is seen in Q48525_LACCA.Residues 59-119 are 73% similar to a (TRANSPOSASE COMPLETE ELEMENT OF) protein domain (PD245714) which is seen in Q9KK23_STRPN.Residues 206-273 are 95% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in Q9KK23_STRPN.Residues 5-56 are 76% similar to a (TNIA ISTB TNIBDELTA1 COMPLETE) protein domain (PD402756) which is seen in Q9KK23_STRPN.Residues 125-198 are 41% similar to a (TRANSPOSASE OF PROTEOME COMPLETE) protein domain (PD395630) which is seen in O50351_LACHE.Residues 10-56 are 48% similar to a (TRANSPOSASE ELEMENT PROTEOME FOR) protein domain (PD195495) which is seen in INSK_ECOLI.Residues 206-256 are 86% similar to a (TRANSPOSASE PLASMID COMPLETE OF) protein domain (PD000334) which is seen in Q53640_STRAG.","","Thu Nov 29 18:40:03 2001","Thu Nov 29 18:42:22 2001","Thu Nov 29 18:42:22 2001","Thu Nov 29 18:42:22 2001","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","Thu Nov 29 18:42:22 2001","","Tue Jan 22 12:29:24 2002","Mon Dec 17 16:15:16 2001","Sat Oct 12 10:07:27 2002","Mon Dec 17 16:15:16 2001","","Mon Dec 17 16:15:16 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0695 is paralogously related (blast p-value < 1e-3) to SMu1719, SMu1283, SMu0395, SMu1258, SMu0514, SMu0798, SMu1250, SMu0934, SMu0537, SMu1237, SMu1236, and SMu1235, all predicted transposases.","Tue Jan 22 12:29:24 2002","","No significant hits to the NCBI PDB database.","SMU.767","Thu Nov 29 18:40:03 2001","Residues 112 to 274 (E-value = 1.2e-40) place SMu0695 in the rve family which is described as Integrase core domain (PF00665)","Mon Dec 17 16:15:16 2001","24379226","","","Rubens,C.E., Heggen,L.M. and Kuypers,J.M.IS861, a group B streptococcal insertion sequence related to IS150and IS3 of Escherichia coliJ. Bacteriol. 171 (10), 5531-5535 (1989)PubMed: 2477359","Tue Jan 22 12:29:24 2002","Mon Dec 17 16:16:37 2001","1","","","SMU.767","" "SMu0696","716797","716480","318","ATGAAAAAATTTCTACGAACTATTTTTGAGCATATTAGGGAATTTGTCGAACCAAGTAAAAAATCTCCTGATATTGTTTTAAAAACGAATCAATTATTACACACTATTTTACAAGCACAGAAAGAGCACGAAGCTGTCCATGTTATCTATTTAGACAAAAGTTTTACAGGTGATATTGTCAAATATGATAAAGAGGCTAATAAACTCATTTTAAAGAACTTTCAAAAGAATATGTCAGCTATTATTAGTATCTCAGATATTAAGCGTTTAACTCTTGTCCCTAAGACCGTTCGTGATTCACAAAGATTAGAAAAGTAA","10.50","7.95","12302","MKKFLRTIFEHIREFVEPSKKSPDIVLKTNQLLHTILQAQKEHEAVHVIYLDKSFTGDIVKYDKEANKLILKNFQKNMSAIISISDIKRLTLVPKTVRDSQRLEK","716485","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypothetical proteins:residues 1-102 are 43% similar to the protein in S.pneumoniae (gi|15902733|) and (gi|15900674|).SMu0696 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 19 15:49:30 2002","Mon Dec 17 16:18:51 2001","Tue Mar 19 15:49:30 2002","Mon Dec 17 16:18:51 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0696 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 10:28:04 2002","","No significant hits to the NCBI PDB database.","SMU.768c","","No significant hits to the Pfam 11.0 database","Mon Dec 17 16:18:51 2001","24379227","","","","","","1","","","SMU.768c","" "SMu0697","716931","717143","213","ATGGCAGAATTTACATTTGAAATTGAAGAAAAACTTTTGGTCTTATCCGAAAACGATAAGGGTTGGACTAAAGAACTTAATCGCGTTAGTTTTAATGGCGCTCCAGCAAAATATGATATTCGCTCTTGGAGCCCCGACCATACCAAAATGGGTAAGGGTATTACACTGACGAATGAAGAATTTGATGTCTTAGTCAATGAATTTAAAAAATAG","4.90","-2.77","8107","MAEFTFEIEEKLLVLSENDKGWTKELNRVSFNGAPAKYDIRSWSPDHTKMGKGITLTNEEFDVLVNEFKK","717142","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-69 are 82% similar to the protein in S.pneumoniae (gi|15900675|). Residues 1-70 are 81% similar to the protein from S.pyogenes (gi|15674678|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0743 (1e-31).","

noIPR
unintegrated

unintegrated
PD170810	$\"[1-64]T$	PD170810

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-67 are 74% similar to a (PROTEOME COMPLETE YDBC TP0352) protein domain (PD170810) which is seen in Q9CIP3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 10:28:36 2002","Mon Dec 17 16:21:41 2001","Thu Jan 24 10:28:36 2002","Mon Dec 17 16:21:41 2001","","Mon Dec 17 16:21:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0697 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 10:28:36 2002","","No significant hits to the NCBI PDB database.","SMU.769","","No significant hits to the Pfam 11.0 database","Mon Dec 17 16:21:41 2001","24379228","","","","","","1","","","SMU.769","914" "SMu0698","718673","717333","1341","ATGAAAACTCATCCAAAAAAGCAATCACTCAGCGAGGTCAATCAGAGCGTTCGTGTTCCTAAAAATGCCTCTTTTTTAACAACTTTAAGAGCTTTTTTAGGACCCGGAGCACTAGTTGCCGTTGGTTATATGGATCCGGGAAATTGGATTACCAGCGTTGTTGGCGGAGCAAGTTATAAATACTTGCTGTTATCAGTTGTTTTGCTGTCTTCACTTATTGCCATGCAGCTACAGCAAATGGCTGGTAAACTGGGCATTGTCTCGCGACAAGATTTAGCGCAGGCAACCGCCTCCCATCTTCCTAAGAGATTGCGTTATCTTTTGTTTATTGTTATTGAATTGGCTCTTATGGCAACAGATTTAGCCGAAGTTATTGGCTCAGGGATTGCCTTACACCTCCTGTTTGGTTGGCCTTTGCTTTTTTCGATCTTTATTACCATTTTAGATGTTTTCTTACTTCTATCTATTATGAAACTTGGATTTAGAAAAATTGAGGCCATCGTTTCAACCCTTATTTTAACCATTCTAGTTATTTTTGTTTACTTAGTTGTTATTTCTCACCCGAGTTTTTCAGGTATTATTAAGGGTTATATTCCTCAGTTTGCTATTTTTGATTCAGCACAAGCAGCTACTAACAGTAGGTTGACCTTAGCACTTGGTATCATTGGCGCAACTGTAATGCCTCACAATTTATACCTGCACTCATCTATCTCTCAGACACGTCAAGTTGATTATAAGCAAAAATCTTCTATTGCTCAGGCCGTTAAATTCATGACTTGGGATTCCAATCTTCAATTAAGTCTCGCCTTTATTGTTAATTCTCTGCTTTTAATTCTTGGAGCCTCGCTTTTTTATGGACATGCCAGTGAAATCAGTGCCTTTTCACAAATGTATAATGCTTTAGCCAATAATCACATTGCTGGAGCAGTTGCCAGTTCTTTTCTTTCAACTCTTTTTGCCATCGCTCTTTTAGCTAGTGGACAAAATTCAACCATTACTGGTACATTAACTGGACAAATTGTTATGGAAGGGTTCTTACATCTCAAAATGCCTCAATGGCTCATTCGCTTAGTAACACGTCTCTTGGCCTTATTACCTGTTTTGATAGCAGCTATTCTTTATGGCAGTCAGGAAAAGATTTTGGATCAGCTGATCGTCTATTCACAGGTTTTCCTGTCAGTTGCTTTGCCATTTTCTATCTTTCCACTGGTTTATTTTACATCACAAAAGAAAATCATGGGAGAATTTGTTAATGCTAAGTGGAATACTTATCTAGCTTATGGAGTTGCCACTGTATTAACAATCCTCAACTTGCAATTAATCATCAATACCATTTTTTAA","10.60","14.15","48782","MKTHPKKQSLSEVNQSVRVPKNASFLTTLRAFLGPGALVAVGYMDPGNWITSVVGGASYKYLLLSVVLLSSLIAMQLQQMAGKLGIVSRQDLAQATASHLPKRLRYLLFIVIELALMATDLAEVIGSGIALHLLFGWPLLFSIFITILDVFLLLSIMKLGFRKIEAIVSTLILTILVIFVYLVVISHPSFSGIIKGYIPQFAIFDSAQAATNSRLTLALGIIGATVMPHNLYLHSSISQTRQVDYKQKSSIAQAVKFMTWDSNLQLSLAFIVNSLLLILGASLFYGHASEISAFSQMYNALANNHIAGAVASSFLSTLFAIALLASGQNSTITGTLTGQIVMEGFLHLKMPQWLIRLVTRLLALLPVLIAAILYGSQEKILDQLIVYSQVFLSVALPFSIFPLVYFTSQKKIMGEFVNAKWNTYLAYGVATVLTILNLQLIINTIF","717338","","manganese transporter/possible HitA ferric iron-binding periplasmic protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to manganese transporters: residues 3-432 are 52% similar to the protein in Lactobacillus brevis (gi14020795).Residues 9-430 are 45% similar to the protein in Listeria innocua (gi16800531). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0745 (1e-164).","

InterPro
IPR001046
Family

Natural resistance-associated macrophage protein
PD001861	$\"[4-61]T$	Nramp
PR00447	$\"[108-134]T$ $\"[136-155]T$ $\"[218-241]T$ $\"[327-346]T$ $\"[355-372]T$ $\"[389-408]T$	NATRESASSCMP
PTHR11706	$\"[86-442]T$	Nramp
PF01566	$\"[51-420]T$	Nramp
TIGR01197	$\"[27-413]T$	nramp

","BeTs to 4 clades of COG1914COG name: Putative Mn transporter, NRAMP familyFunctional Class: PThe phylogenetic pattern of COG1914 is ----Y---ebr----------Number of proteins in this genome belonging to this COG is 2","***** PR00447 (Natural resistance-associated macrophage protein signature) with a combined E-value of 3.3e-61. PR00447A 108-134 PR00447B 136-155 PR00447C 161-182 PR00447D 218-241 PR00447E 327-346 PR00447F 355-372 PR00447G 389-408","Residues 51-284 are 52% similar to a (TRANSPORT MACROPHAGE TRANSMEMBRANE NATURAL) protein domain (PD001861) which is seen in Q9CGL4_LACLA.Residues 17-49 are 69% similar to a (MANGANESE TRANSPORT PROTEOME COMPLETE) protein domain (PD347650) which is seen in Q9CGL4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 12:58:59 2006","Sat Oct 12 10:13:12 2002","Wed Sep 27 12:58:59 2006","Mon Dec 17 16:23:10 2001","Mon Dec 17 16:23:10 2001","Mon Dec 17 16:23:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0698 is paralogously related (blast p-value < 1e-3) to SMu1013, a predicted conserved hypothetical protein.","Thu Jan 24 10:30:07 2002","","No significant hits to the NCBI PDB database.","SMU.770c","","Residues 51 to 420 (E-value = 5.8e-117) place SMu0698 in the Nramp family which is described as Natural resistance-associated macrophage protein (PF01566)","Mon Dec 17 16:23:10 2001","24379229","","","Hayashi,N., Ito,M., Horiike,S. and Taguchi,H.Molecular cloning of a putative divalent-cation transporter gene as a new genetic marker for the identification of Lactobacillus brevis strains capable of growing in beerAppl. Microbiol. Biotechnol. 55 (5), 596-603 (2001)PubMed: 11414327","","Mon Dec 17 16:25:51 2001","1","","","SMU.770c","78" "SMu0699","719347","719213","135","ATGAAACGATACTATATTTCTTACCTATCAGCTGCTATTTTTATTGTCTATGGTCTCTTTTCTTCAAAATTAATTTTTGCAGCACTGGGACTTGTTTTTCTACTTATCGGTCTCAGGGACAGTCGTTCCAAATGA","11.00","4.97","4988","MKRYYISYLSAAIFIVYGLFSSKLIFAALGLVFLLIGLRDSRSK","719218","","hypothetical protein","Extracellular","No significant hits in gapped BLAST found.SMu0699 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-43]?$	signal-peptide
tmhmm	$\"[4-38]?$	transmembrane_regions

InterPro
IPR002479
Repeat

Putative cell wall binding repeat
PF01473	$\"[150-169]T$ $\"[215-233]T$	CW_binding_1
PS51170	$\"[149-169]T$ $\"[170-189]T$ $\"[191-212]T$ $\"[214-233]T$ $\"[234-253]T$ $\"[277-296]T$	CW

InterPro
IPR005877
Domain

YSIRK Gram-positive signal peptide
PF04650	$\"[3-29]T$	YSIRK_signal
TIGR01168	$\"[1-39]T$	YSIRK_signal

noIPR
unintegrated

unintegrated
G3DSA:2.10.270.10	$\"[157-220]T$ $\"[221-296]T$	G3DSA:2.10.270.10
G3DSA:3.40.50.1820	$\"[452-657]T$	G3DSA:3.40.50.1820
SSF53474	$\"[421-649]T$	SSF53474

","No hits to the COGs database.","***** IPB003318 (Glucosyltransferase S precursor) with a combined E-value of 9.8e-17. IPB003318R 158-191 IPB003318R 222-255 IPB003318R 201-234","Residues 534-586 are 64% similar to a (DEPOLYMERASE HYDROLASE) protein domain (PD005433) which is seen in Q9KJ79_STRMU.Residues 150-254 are 51% similar to a (TRANSFERASE SURFACE PSPC DEXTRANSUCRASE) protein domain (PD000439) which is seen in Q59983_BBBBB.Residues 603-725 are 47% similar to a (BGLB) protein domain (PD304507) which is seen in Q9KJ79_STRMU.Residues 200-277 are 38% similar to a (GLUCAN-BINDING GBP PRECURSOR REPEAT) protein domain (PD236206) which is seen in Q54447_STRMU.Residues 171-296 are 32% similar to a (DEXTRANSUCRASE GLYCOSYLTRANSFERASE) protein domain (PD174018) which is seen in Q9ZAR4_LEUME.Residues 152-198 are 44% similar to a (TRANSFERASE SIGNAL 6-GLUCOSYLTRANSFERASE) protein domain (PD016627) which is seen in Q00599_STRSL.Residues 191-251 are 46% similar to a (TRANSFERASE SIGNAL PRECURSOR) protein domain (PD285093) which is seen in GTFD_STRMU.Residues 456-620 are 32% similar to a (PROTEOME COMPLETE PM1358) protein domain (PD276067) which is seen in Q9CL84_PASMU.Residues 300-529 are 39% similar to a (BGLB) protein domain (PD316577) which is seen in Q9KJ79_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 7 09:11:13 2004","Wed Jul 7 09:11:13 2004","Wed Jul 7 09:00:00 2004","Mon Dec 17 16:36:59 2001","Mon Dec 17 16:36:59 2001","Mon Dec 17 16:36:59 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0700 is paralogously related (blast p-value < 1e-3) to SMu0891 and SMu0892, both predicted beta-glucosidase BglB, SMu0914,a predicted glucosyltransferase-I,SMu0827,a predicted glucosyltransferase-S, SMu0915,a predicated glucosyltransferase-SI, SMu1916,a predicted glucan-binding protein, SMu0057,a predicted conserved hypothetical protein, SMu0555, a predicted 40K cell wall protein precursor (sr 5' region);choline binding protein D, and SMu0999, a predicted hypothetical protein; possible surface protein.","Wed Jul 7 09:11:13 2004","","No significant hits to the NCBI PDB database.","SMU.772","","Residues 3 to 29 (E-value = 5e-07) place SMu0700 in the YSIRK_signal family which is described as YSIRK type signal peptide (PF04650)Residues 160 to 179 (E-value = 4.3e-06) place SMu0700 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 224 to 243 (E-value = 1.6e-07) place SMu0700 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)","Wed Jul 7 09:00:00 2004","24379231","","Shah DS, Russell RR.A novel glucan-binding protein with lipase activity from the oral pathogen Streptococcus mutans.Microbiology. 2004 Jun;150(Pt 6):1947-56.PMID: 15184580Cote,C.K., Cvitkovitch,D., Bleiweis,A.S. and Honeyman,A.L.A novel beta-glucoside-specific PTS locus from streptococcus mutans that is not inhibited by glucoseMicrobiology 146 (Pt 7), 1555-1563 (2000)PubMed: 10878120Fujiwara T, Terao Y, Hoshino T, Kawabata S, Ooshima T, Sobue S, Kimura S, Hamada SMolecular analyses of glucosyltransferase genes among strains of Streptococcus mutans.FEMS Microbiol Lett 1998 Apr 15;161(2):331-6PubMed: 9570124 PMID: 9570124Shiroza T, Ueda S, Kuramitsu HKSequence analysis of the gtfB gene from Streptococcus mutans.J Bacteriol 1987 Sep;169(9):4263-70 PubMed: 3040685PMID: 3040685Honda O, Kato C, Kuramitsu HKNucleotide sequence of the Streptococcus mutans gtfD gene encoding the glucosyltransferase-S enzyme.J Gen Microbiol 1990 Oct;136 ( Pt 10):2099-105 PubMed: 2148600PMID: 2148600","","Wed Jul 7 09:11:13 2004","","1","","","SMU.772","" "SMu0701","723844","722354","1491","ATGTCACATCAACATACAGAAGAATTGAATGACCAACAAATTGTCCGCCGCGAAAAAATGGAGGCTTTGACTGAACAAGGAATAGATCCATTTGGCAAGCGTTTTGAACGTACGGCTACTTCTGGTCAATTAAAAGAAAAATATGCTGACAAAACAAAAGAAGAATTACATGACATCAATGAAACGGCTACCATTGCTGGACGTCTGATGACCAAACGAGGTAAAGGTAAGGTTGGCTTTGCCCACCTTCAAGACCGTGAAGGTCAAATTCAAATTTATGTCCGTAAAGATACTGTTGGCGATGATAATTATCAAATTTTTAAAAAGGCGGATATTGGAGACTTTTTAGGTGTAGAAGGTGAAATTATGCGTACAGATATGGGAGAGCTTTCTATCAAAGCTACGCATATAACGCATCTTTCCAAGGCACTGCGTCCACTGCCTGAAAAATTCCATGGTTTAACTGATGTTGAAACCATCTACCGCAAGCGTTACCTCGATTTGATTTCTAACCGCGAGAGTCTGGAACGCTTTATCACTCGTTCAAAAATCATCTCAGAAATCCGTCGCTATCTGGATGGCCTTGGTTTCTTAGAAGTAGAAACGCCTGTCCTTCATAATGAAGCTGGTGGTGCTGCTGCTAAACCCTTCACAACCCATCATAACGCTCAAGATATGGATATGGTTCTTCGTATCGCAACAGAACTGCATTTAAAACGACTGATTGTTGGTGGTATGGAAAGAGTTTATGAAATGGGACGTATTTTCCGTAATGAAGGAATGGATGCCACTCATAATCCTGAATTCACTTCAATTGAAGTTTACCAAGCCTATGCTGACTTTGAAGATATCATGGATTTAACAGAAGGTATTGTGCAACATGCTGCTACAGCCGTTAAAGGTGATGGTCCTATTACTTATCAAGGTACCGAAATTAAGATTAATGAACCCTTCAAACGTGCTCACATTGTTGATTTAATCAAGGAAGTGACTGGTGTTGATTTTTGGAAAGAAATGACCTTGGCGGAAGCACAGGCTCTTGCTCAAGAAAAAAATGTTCCACTTGAAAAACACTACACTTCTGTTGGACACATTATCAATGCCTTCTTTGAAGAATTCGTCGAAGAAACACTCATTCAACCAATCTTTGTTTATGGCCATCCTGTTGAAGTTTCACCACTAGCTAAGAAAAATGCAGATGACCCTCGTTTCACAGACCGTTTTGAACTTTTCATTATGACTAAGGAATACGGAAATGCCTTCACTGAATTAAATGACCCAATTGATCAATTGGAGCGCTTTAAAGCTCAAGCCGCTGCCAAAGAATTGGGAGACGACGAAGCCACAGGCATTGACTATGACTATGTTGAAGCCCTTGAATACGGCATGCCACCAACAGGCGGACTCGGTATTGGTATTGACCGCTTAGTCATGCTCTTAACAGACACAACAACCATTCGCGATGTATTGTTATTCCCAACGATGAAGTAA","5.10","-20.83","56369","MSHQHTEELNDQQIVRREKMEALTEQGIDPFGKRFERTATSGQLKEKYADKTKEELHDINETATIAGRLMTKRGKGKVGFAHLQDREGQIQIYVRKDTVGDDNYQIFKKADIGDFLGVEGEIMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETIYRKRYLDLISNRESLERFITRSKIISEIRRYLDGLGFLEVETPVLHNEAGGAAAKPFTTHHNAQDMDMVLRIATELHLKRLIVGGMERVYEMGRIFRNEGMDATHNPEFTSIEVYQAYADFEDIMDLTEGIVQHAATAVKGDGPITYQGTEIKINEPFKRAHIVDLIKEVTGVDFWKEMTLAEAQALAQEKNVPLEKHYTSVGHIINAFFEEFVEETLIQPIFVYGHPVEVSPLAKKNADDPRFTDRFELFIMTKEYGNAFTELNDPIDQLERFKAQAAAKELGDDEATGIDYDYVEALEYGMPPTGGLGIGIDRLVMLLTDTTTIRDVLLFPTMK","722359","For other 'lys' genes see SMu1568 (lysA) and SMu1594 (lysC). ","lysyl-tRNA synthetase","Cytoplasm","Several matches in gapped BLAST to lysyl-tRNA synthetase: residues 1-496 are 87% similar to the enzyme in S.pneumoniae (gi|15902670|)and are 77% similar to the protein from S.pyogenes (gi|15674679).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0750 (0.0).","

InterPro
IPR002313
Family

Lysyl-tRNA synthetase, class-2
PR00982	$\"[193-203]T$ $\"[209-225]T$ $\"[238-251]T$ $\"[256-273]T$ $\"[380-396]T$	TRNASYNTHLYS
PTHR22594:SF4	$\"[127-496]T$	tRNA-synt_lys_2
TIGR00499	$\"[8-496]T$	lysS_bact

InterPro
IPR004364
Domain

tRNA synthetase, class II (D, K and N)
PF00152	$\"[156-496]T$	tRNA-synt_2

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[63-140]T$	tRNA_anti

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[181-493]T$	AA_TRNA_LIGASE_II

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[3-148]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[149-496]T$	G3DSA:3.30.930.10
PTHR22594	$\"[127-496]T$	PTHR22594
SSF50249	$\"[6-149]T$	Nucleic_acid_OB
SSF55681	$\"[156-496]T$	SSF55681

","BeTs to 10 clades of COG1190COG name: Lysyl-tRNA synthetasesFunctional Class: JThe phylogenetic pattern of COG1190 is ----YQvcEbRHujgp-lin-Number of proteins in this genome belonging to this COG is 1","***** IPB002106 (Aminoacyl-transfer RNA synthetases class-II) with a combined E-value of 5.4e-06. IPB002106A 191-203 IPB002106B 472-486","Residues 265-309 are 48% similar to a (SYNTHETASE LIGASE LYSYL-TRNA ATP-BINDING) protein domain (PD110920) which is seen in Q9JYU6_NEIMB.Residues 10-156 are 76% similar to a (SYNTHETASE LIGASE LYSYL-TRNA AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD003714) which is seen in Q9CII7_LACLA.Residues 265-323 are 50% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD000871) which is seen in SYK_THEMA.Residues 452-496 are 80% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000848) which is seen in Q9L3G6_XANCP.Residues 65-168 are 31% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD190154) which is seen in SYD_METJA.Residues 307-407 are 37% similar to a (SYNTHETASE LIGASE LYSYL-TRNA) protein domain (PD403149) which is seen in SYK_HAEIN.Residues 307-428 are 70% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD110938) which is seen in Q9CII7_LACLA.Residues 265-409 are 23% similar to a (LIGASE SYNTHETASE ATP-BINDING LYSYL-TRNA) protein domain (PD206465) which is seen in SYK_MYCLE.Residues 188-407 are 27% similar to a (SYNTHETASE LIGASE LYSYL-TRNA) protein domain (PD190229) which is seen in SYK3_ECOLI.Residues 204-264 are 81% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA LYSYL-TRNA ATP-BINDING) protein domain (PD318428) which is seen in Q9CII7_LACLA.Residues 161-203 are 53% similar to a (SYNTHETASE LIGASE ATP-BINDING LYSYL-TRNA) protein domain (PD346096) which is seen in Q9LJE2_ARATH.Residues 59-168 are 33% similar to a (SYNTHETASE LIGASE ASPARTYL-TRNA) protein domain (PD228079) which is seen in Q9PCC5_XYLFA.Residues 265-301 are 75% similar to a (SYNTHETASE PROTEOME COMPLETE LYSYL-TRNA) protein domain (PD374736) which is seen in Q9CII7_LACLA.Residues 408-448 are 70% similar to a (SYNTHETASE LIGASE LYSYL-TRNA) protein domain (PD334399) which is seen in SYK_HAEIN.Residues 444-492 are 81% similar to a (SYNTHETASE LIGASE LYSYL-TRNA) protein domain (PD186099) which is seen in SYK_MYCFE.Residues 158-203 are 82% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD002022) which is seen in Q9CII7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:35:52 2002","Tue Dec 18 08:14:31 2001","Sat Oct 12 10:35:52 2002","Tue Dec 18 08:14:31 2001","Tue Dec 18 08:14:31 2001","Tue Dec 18 08:14:31 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0701 is paralogously related (blast p-value < 1e-3) to SMu1660 and SMu1907,both predicted aspartyl-tRNA synthetases, and SMu1198, a predicted asparaginyl-tRNA synthetase.","Thu Jan 24 10:46:31 2002","Tue Dec 18 08:14:31 2001","pdb|1BBU|A Chain A, Lysyl-Trna Synthetase (Lyss) Complexed With... 471 1e-133pdb|1E1O|A Chain A, Lysyl-Trna Synthetase (Lysu) Hexagonal For,... 469 4e-133pdb|1B8A|A Chain A, Aspartyl-Trna Synthetase >gi|4388837|pdb|1B... 119 9e-028","SMU.773c","","Residues 63 to 140 (E-value = 6.3e-20) place SMu0701 in the tRNA_anti family which is described as OB-fold nucleic acid binding domain (PF01336)Residues 156 to 496 (E-value = 3.7e-169) place SMu0701 in the tRNA-synt_2 family which is described as tRNA synthetases class II (D, K and N) (PF00152)","Tue Dec 18 08:14:31 2001","24379232","","","Takita,T., Shimizu,N., Sukata,T., Hashimoto,S.,Akita,E.,Yokota,T., Esaki,N.,Soda,K., Inouye,K. and Tonomura,B.Lysyl-tRNA synthetase of Bacillus stearothermophilus molecularcloning and expression of the geneBiosci. Biotechnol. Biochem. 64 (2), 432-437 (2000)PubMed: 10737207Leveque,F., Plateau,P., Dessen,P. and Blanquet,S.Homology of lysS and lysU, the two Escherichia coli genes encodingdistinct lysyl-tRNA synthetase speciesNucleic Acids Res. 18 (2), 305-312 (1990)PubMed: 2183178Commans,S., Plateau,P., Blanquet,S. and Dardel,F.Solution structure of the anticodon-binding domain of Escherichiacoli lysyl-tRNA synthetase and studies of its interaction withtRNA(Lys)J. Mol. Biol. 253 (1), 100-113 (1995)PubMed: 7473706","","Tue Dec 18 08:20:59 2001","1","","","SMU.773c","79" "SMu0702","724249","725151","903","ATGATTACTGCGATTGTTTTTGATGTTGATGATACGATCTATGATCAACAGGCACCATACAGAATTGCCGTGGGAAAGTGTTTCCCTGATTTTGATATGGCAAATATAAATCAGGCTTATATCCGTTTCCGCCACTACTCTGATACAGGTTTTCCACGTGTTATGGCTAATGAATGGACAACTGAGTATTTTCGTTTCTGGCGCTGCCAAAAAACCTTGTTGGATTTTGATTATCGGCAGATTGGCGAAGAGGAAGGTCAGTATTTTCAAGAAGTCTATGAAAAAGAACTTGATCAGATTAGTATGTTGGATGAGATGCGCTTGACTTTGGATTTTCTTAAAGAAAAGAATATTCCCATGGGAGTCATTACAAATGGGCCGACTGAGCATCAATTAAAAAAAGTTAAGAAGTTAGGCCTTTATGATTATGTTGATCCTAAGCGTGTCTTGGTCAGTCAGGCAACAGGTTTTCAAAAACCTCAAAAGGAAATCTTTAATTTAGCTGCTGAGCAGTTTGAAATGAATCCAGATACCACTTTGTATGTGGGAGATTCTTATGATAATGACATCAAGGGAGCCCATGATAGTGGCTGGCATTCTATGTGGTTTAATCACCGTGGCCGTCGTTTAAAGGCTGGAACGAAGCCTGTTTTTGATTTGCAGATTGATTCTTTTGAACAGCTTTACGGTGCAGTCAAAGTTTTGTTTGATCTACCTAGTCATAAATTTATTTTTGACGCTAATGATTACACTAATCCTATTTTACAGTTGGGGATTAACAATGGTTTAATGATGGCAGCAGAACGTTTGCTTGAAAGTAATATTAGTATTGATAAGGTCGTTATTTTACTTCGGCTAGACAAAAATCAAGAAAGAATACTGCGTTTAAAATATGCAAACTAA","5.30","-6.63","35140","MITAIVFDVDDTIYDQQAPYRIAVGKCFPDFDMANINQAYIRFRHYSDTGFPRVMANEWTTEYFRFWRCQKTLLDFDYRQIGEEEGQYFQEVYEKELDQISMLDEMRLTLDFLKEKNIPMGVITNGPTEHQLKKVKKLGLYDYVDPKRVLVSQATGFQKPQKEIFNLAAEQFEMNPDTTLYVGDSYDNDIKGAHDSGWHSMWFNHRGRRLKAGTKPVFDLQIDSFEQLYGAVKVLFDLPSHKFIFDANDYTNPILQLGINNGLMMAAERLLESNISIDKVVILLRLDKNQERILRLKYAN","725150","","hydrolase, haloacid dehalogenase-like","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein: residues 1-299 are 81% similar to the protein in S.pyogenes (gi15674680).Residues 4-233 are 33% similar to the protein in S.suis (gi15553026).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0751 (1e-148).","

InterPro
IPR005833
Family

Haloacid dehydrogenase/epoxide hydrolase
PR00413	$\"[2-13]T$ $\"[113-126]T$ $\"[164-184]T$	HADHALOGNASE

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[2-206]T$	Hydrolase

InterPro
IPR006439
Family

HAD-superfamily hydrolase, subfamily IA, variant 1
TIGR01549	$\"[4-197]T$	HAD-SF-IA-v1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[102-244]T$	G3DSA:3.40.50.1000
PTHR12725	$\"[1-224]T$	PTHR12725
PTHR12725:SF4	$\"[1-224]T$	PTHR12725:SF4
SSF56784	$\"[1-233]T$	SSF56784

","BeTs to 7 clades of COG1011COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG1011 is -mtKY-V-EB---j--o----Number of proteins in this genome belonging to this COG is 2","***** PR00413 (Haloacid dehalogenase/epoxide hydrolase family signature) with a combined E-value of 3.5e-06. PR00413A 2-13 PR00413D 113-126 PR00413F 164-184 PR00413G 192-205","Residues 106-202 are 35% similar to a (PROTEOME COMPLETE HYDROLASE PHOSPHATASE DEHALOGENASE) protein domain (PD000816) which is seen in O07500_BACFI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 08:11:57 2002","Fri Sep 8 13:41:18 2006","Fri Sep 8 13:41:18 2006","Tue Dec 18 08:23:09 2001","Tue Dec 18 08:23:09 2001","Tue Dec 18 08:23:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0702 is paralogously related (blast p-value < 1e-3) to SMu1138, and SMu1640, both predicted conserved hypothetical proteins.","Thu Jan 24 10:48:59 2002","","No significant hits to the NCBI PDB database.","SMU.774","","Residues 2 to 206 (E-value = 1.4e-19) place SMu0702 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Tue Dec 18 08:23:09 2001","24379233","","","","","","1","","","SMU.774","317" "SMu0703","727610","725457","2154","ATGAAAAAAATCGCTAAATTTCTCTTAAGCGCTGTTAATACCCGTTTAGGGTTTATTTTAACGCTTGTATTCATTTATTGGCTAAAAACAATTTGGGCTTATAATGTTGATTTTAGTTTAGATTTAGACAAATCATACCAATTTTTTTTGACACTAATAAACCCCATTCCCATTAGTTTGTTGCTGTTAGGATTGGCACTTTATATCAAAAATACACGCATCTTTTATTTCACTGCGATTGTTATTTATACTCTACTTAATATTCTTCTCATTGCTAATTCTATTTACTTTCGAGAATTTTCAGACTTTCTAACAGTTAGTGCAGCATTAGCAAGCAGCAAGACTTCTGCTGGTTTAGGGGCTTCTGCCCTTAATTTATTGAGACCTTGGGATGCTATCTATATTCTAGATTATGTCATTTTAATCACTCTTTTTTCTCTTAAAAAACTTTCTTTTGACCAAAGACCCTTCAACAAAAGAGCTAGCTTTGCTATTTCTGCTCTCTCAGGTCTCCTTTTTTCTGTCAATCTTTTCATGGCTGAAATTGATCGGCCTGAATTACTAACACGTGGGTTTTCAAATATTTATGTTGTCCGTGCTTTAGGGTTGCCAGCATTTAGTGCCTACAGTGCTAATCAAACTTACCAAACACAAAAAGTACGCTCAGAAGCAACTGCTTCTGAATTCAATACTGTTAAAAAATATGTAAAAGAACATTATGCCGCTCCCAACCCTAAATACTATGGGCTTGCAAAAGGTAAAAATGTCATTGTGCTTCATTTAGAAAGTTTTCAGCAATTTCTGATTGATTATAAGCTCAATATTGATGGCAAACAATATGAAGTAACACCTTTTTTGAATTCACTTTACCATTCTAAGGAAACATTTGCTTTTTCAAACTTCTTCCATCAAGTTAAGGCCGGAAAAACTTCTGATGCTGAAACATTAATGGAGACATCACTCTTTGGTTTAAACCAAGGCTCCTTCTTCGTTCAATACGGAGGTGATAATACACAGCAGGCTGCACCGCATATTCTAAAGGATACCAACAATTACAGCAGTGCCGTCTTTCATGGTAATATCGGTACTTTCTGGAACCGTAATAATGCCTACAAACAATTGGGCTATCAACATTTCTTTGATCAATCTTATATGTCAAAAATGACCAAGGACAACTCTTTCCAATATGGGCTTAATGATAAAGTTATGTTTGCAGATTCCATTAAATACTTGGAACACATGCAACAGCCTTTCTACACAAAATTTATCACCGTTTCGAATCACTACCCTTATCAAAGTTTAGATGGTGATGATACTGGCTTTCCTCTTGCCAAAACAGAAGATAAAACAATTAATGGCTACTTTGCTACAGCTAACTATCTAGATGCTGCTATCAAAGATTTCTTTGATTACTTAAAAGCCTCTGGTTTATACAAAAATTCCATTATTGTTATGTATGGTGACCACTATGGTATTGCTAATTCAAGAAATACTGATCTTGCACCACTTTTAGGCAAGGATTCACAAACTTGGACTGAATACAACAATGCTATGTTACAGCGTGTTCCTTATATGATTCACGTTCCCGGAACAGATAAAGGATTTATCAGTAACACCTATGGCGGAGAAGTTGATGCTTTGCCAACACTGCTTCACCTTTTGGGTATTGATAATAAAAATTATATTGAATTAGGACAAGATTTACTGTCTCCTAACAACAAGCAGCTTGTTGCTTTCCGTTCCGAAGGTAATTATATTACACCTAATTATACAAGTTACAGCGGCCGTGTTTACGACACTAAAACAGGTGTTGAGATCACAAATCCAGACGAAGCAACGACTGCTAAACTAAAAGAACTTCGTGATGCAGCAGACAAACAGTTAAATACAAGCGATAACATTCAAACAGGTGATTTACTGCGTTTTGATAAGGATAGTGGTCTAAAACCAATTGATATCGGTTCTATTTCATATAAAAAGGATTCTCTGAAGAAACTAAAGAAGATTGAAAAGAAACTAGATAAGAATTCAACCAGTCTTTATAGCAAAAATGGTAACAAATCAACTCAAGATTTATACAAGGCACCAAGTTATAAAGAACTACACCCAGAAGAATCACCAAAAGAATCCTCAACAACTACATCATCAAAATAA","9.70","11.16","81184","MKKIAKFLLSAVNTRLGFILTLVFIYWLKTIWAYNVDFSLDLDKSYQFFLTLINPIPISLLLLGLALYIKNTRIFYFTAIVIYTLLNILLIANSIYFREFSDFLTVSAALASSKTSAGLGASALNLLRPWDAIYILDYVILITLFSLKKLSFDQRPFNKRASFAISALSGLLFSVNLFMAEIDRPELLTRGFSNIYVVRALGLPAFSAYSANQTYQTQKVRSEATASEFNTVKKYVKEHYAAPNPKYYGLAKGKNVIVLHLESFQQFLIDYKLNIDGKQYEVTPFLNSLYHSKETFAFSNFFHQVKAGKTSDAETLMETSLFGLNQGSFFVQYGGDNTQQAAPHILKDTNNYSSAVFHGNIGTFWNRNNAYKQLGYQHFFDQSYMSKMTKDNSFQYGLNDKVMFADSIKYLEHMQQPFYTKFITVSNHYPYQSLDGDDTGFPLAKTEDKTINGYFATANYLDAAIKDFFDYLKASGLYKNSIIVMYGDHYGIANSRNTDLAPLLGKDSQTWTEYNNAMLQRVPYMIHVPGTDKGFISNTYGGEVDALPTLLHLLGIDNKNYIELGQDLLSPNNKQLVAFRSEGNYITPNYTSYSGRVYDTKTGVEITNPDEATTAKLKELRDAADKQLNTSDNIQTGDLLRFDKDSGLKPIDIGSISYKKDSLKKLKKIEKKLDKNSTSLYSKNGNKSTQDLYKAPSYKELHPEESPKESSTTTSSK","725462","","conserved hypothetical protein","Membrane, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-702 are 66% similar to the enzyme in S.pyogenes (gi|15674849|). Residues 6-689 are 40% similar to the protein from Lactococcus lactis subsp. lactis (gi|15672787|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1381 (0.0).","

InterPro
IPR000917
Domain

Sulfatase
PF00884	$\"[252-573]T$	Sulfatase

InterPro
IPR001952
Family

Alkaline phosphatase
G3DSA:3.40.720.10	$\"[252-604]T$	Alk_phosphtse

InterPro
IPR012160
Family

Membrane sulphatase, HI1246-related
PIRSF005091	$\"[2-647]T$	Mmb_sulf_HI1246

noIPR
unintegrated

unintegrated
PTHR10342	$\"[402-557]T$	PTHR10342
SSF53649	$\"[252-667]T$	SSF53649

","BeTs to 4 clades of COG1368COG name: Phosphoglycerol transferase MdoB and related proteins, alkaline phosphatase superfamilyFunctional Class: MThe phylogenetic pattern of COG1368 is ------v-eB-Huj-------Number of proteins in this genome belonging to this COG is 2","***** IPB000917 (Sulfatase) with a combined E-value of 7.5e-06. IPB000917F 461-490 IPB000917H 545-555","Residues 81-384 are 47% similar to a (PROTEOME COMPLETE TRANSMEMBRANE YFLE) protein domain (PD018046) which is seen in O34952_BACSU.Residues 397-649 are 47% similar to a (PROTEOME COMPLETE MEMBRANE INTEGRAL) protein domain (PD122771) which is seen in O06487_BACSU.Residues 6-225 are 27% similar to a (PROTEOME COMPLETE YIBC) protein domain (PD400754) which is seen in Q9CHC7_LACLA.Residues 343-489 are 26% similar to a (CAPSULAR PROTEOME RKPI COMPLETE) protein domain (PD025398) which is seen in O82879_STRMU.Residues 583-642 are 46% similar to a (PROTEOME COMPLETE YFLE YVGJ) protein domain (PD336179) which is seen in O34952_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 10:49:52 2002","Tue Dec 18 08:50:06 2001","Thu Jan 24 10:49:52 2002","Tue Dec 18 08:50:06 2001","Tue Dec 18 08:50:06 2001","Tue Dec 18 08:50:06 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0703 is paralogously related (blast p-value < 1e-3) to SMu0755, a predicted hypothetical protein.","Thu Jan 24 10:49:52 2002","","No significant hits to the NCBI PDB database.","SMU.775c","","Residues 252 to 575 (E-value = 2.8e-28) place SMu0703 in the Sulfatase family which is described as Sulfatase (PF00884)","Tue Dec 18 08:50:06 2001","24379234","","","","","","1","","","SMU.775c","146" "SMu0704","727743","728900","1158","ATGATTAAACTTATGGTGGGTTCTTTTGCGGAGAAAAAACTTAAACGAGGGGTGCAATTATTAAGTAGCAGAGATTATCCAAATTTAAATTTGGATAATCAAGTTGTTCAATTATATTCTGACGCAGATATTTTTTTAGGAACAGCCTATTTATCAAAGCAAAATAAAGGCGTTGGTTGGTTAATTTCACCTAAAAAAGTATCACTTAATGTGACTTATTTTATTAAATTATTTCAATGGTCTAAAGATAAGCGAAAAAATTTTGCTCATTCTAAATTAACAACAGCCTACCGTCTTTTTAATCAAGATGGTGATTCTTTTGGTGGTGTGACAATTGATTGCTATGGTGATTTTGTGCTTTTTTCTTGGTACAATTCTTTTGTTTATCAGATTAGAGATGAGATAGTAGCTGCTTTTCGTCAAGTGTATCCGAATTTTTTAGGTGCCTATGAGAAGATTCGATTCAAAGGGATTGATAATGTTTCTGCTCATCTTTATGGTCAAGAAGCACCAGAACAATTTCTTATTTTGGAAAATGGGATATCTTATAATGTCTTCTTAAACGATGGACTCATGACAGGTATTTTTTTGGATCAGCGCCAAGTAAGAAATGAGTTGATTAATGGATCAGCTGCGGGAAAAACTGTTTTAAATCTCTTTTCATACACAGCAGCTTTTTCTGTTGCTGCTGCTATGGGCGGTGCAATGGCAACGACTTCGGTGGATTTGGCTAAACGCTCAAGAGCTCTGTCCTTGGCTCATTTTGAGGCGAATCATTTGGACATGGCAAATCATCAATTAGTGGTCATGGATGTTTTCGACTATTTTAAATATGCTAGGCGTCATCACTTAACCTATGATATTATTATTATTGATCCTCCTAGTTTTGCCAGAAATAAAAAAGAGGTTTTTTCTGTTTCCAAAGATTATCATAAGTTAATTAGACAGGGGTTGGAGATTTTATCTGAAAACGGTCTTATCATTGCTTCAACGAATGCAGCTAATATGACAGTTTCTCAGTTTAAAAAACAAATCGAAAAAGGTTTCGGAAAACAAAAGCATACTTATCTTGATTTACAGCAATTGCCAAGTGATTTTGCAGTAAATGTTCAAGACGAAAGCAGCAATTATTTAAAAGTATTTACAATAAAGGTTTAG","10.00","10.12","43670","MIKLMVGSFAEKKLKRGVQLLSSRDYPNLNLDNQVVQLYSDADIFLGTAYLSKQNKGVGWLISPKKVSLNVTYFIKLFQWSKDKRKNFAHSKLTTAYRLFNQDGDSFGGVTIDCYGDFVLFSWYNSFVYQIRDEIVAAFRQVYPNFLGAYEKIRFKGIDNVSAHLYGQEAPEQFLILENGISYNVFLNDGLMTGIFLDQRQVRNELINGSAAGKTVLNLFSYTAAFSVAAAMGGAMATTSVDLAKRSRALSLAHFEANHLDMANHQLVVMDVFDYFKYARRHHLTYDIIIIDPPSFARNKKEVFSVSKDYHKLIRQGLEILSENGLIIASTNAANMTVSQFKKQIEKGFGKQKHTYLDLQQLPSDFAVNVQDESSNYLKVFTIKV","728899","","conserved hypothetical protein; possible methyltransferase","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-385 are 61% similar to the protein in S.pyogenes (gi15674850)and are 57% similar to the protein from S.pneumoniae (gi15903279).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1380 (1e-141).","

InterPro
IPR001360
Family

Glycoside hydrolase, family 1
PS00572	$\"[174-182]?$	GLYCOSYL_HYDROL_F1_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[211-332]T$	G3DSA:3.40.50.150
SSF53335	$\"[90-379]T$	SSF53335

","BeTs to 7 clades of COG1092COG name: Predicted SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG1092 is -M-k-Qv-Eb-h------in-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 211-289 are 39% similar to a (PROTEOME COMPLETE XF2651 YCFD) protein domain (PD030981) which is seen in Q9CIV0_LACLA.Residues 3-203 are 46% similar to a (COMPLETE PROTEOME XF0407 APE0141) protein domain (PD009723) which is seen in Q9CIV0_LACLA.Residues 169-332 are 29% similar to a (PROTEOME COMPLETE PA1407) protein domain (PD252572) which is seen in Q9I3T7_PSEAE.Residues 290-385 are 44% similar to a (PROTEOME YCFD COMPLETE EPR-GALK) protein domain (PD255185) which is seen in Q9CIV0_LACLA.Residues 216-324 are 27% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD191285) which is seen in Q9PJZ2_CHLMU.Residues 214-289 are 42% similar to a (DOMAIN OF UNKNO N) protein domain (PD389947) which is seen in Q9EYR1_STAXY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:37:22 2002","Thu Sep 14 10:01:04 2006","Thu Sep 14 10:01:04 2006","Tue Dec 18 08:52:14 2001","","Tue Dec 18 08:52:14 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0704 is paralogously related (blast p-value < 1e-3) to SMu1577, a predicted UDP-N-acetyl muramate-alanine ligase.","Thu Jan 24 10:51:06 2002","","No significant hits to the NCBI PDB database.","SMU.776","","No significant hits to the Pfam 11.0 database","Tue Dec 18 08:52:14 2001","24379235","","","","","","1","","","SMU.776","415" "SMu0705","728907","729584","678","ATGAAAATAGTAGTTCCTGTTATGCCTCAAAATATTGAAGAGGCTAACCAACTTGATTTAACGAGGATTGATAGTACAGATATTATTGAATGGCGGGCAGATTATTTAGTTAAAGATGATATTTTAACGGTAGCACCGGCTATTTTTGAAAAGTTCTCGGGTCATGAAGTGATTTTTACTTTGCGTACAGAAAAAGAAGGAGGAAATATTTCCCTTTCTAATGAAGACTATCTTGCTATCATCCGTGATATTGCGGCTCTTTATCAGCCTGATTACATTGACTTTGAATATTTTTCCTACCGTGATGTTTTAGAGGAAATGTATGATTTTTCAAATCTTATTTTGTCTTATCACAATTTTGAAGAAACACCAGAAAATCTAATGGAAGTCTTTTCAGAGTTAACAGCTTTAGCTCCGCGTGTTGTCAAGATTGCTGTCATGCCTAAAAATGAACAGGATGTTCTTGATTTGATGAACTATACAAGAGGCTTTAAAACTTTAAATCCCAATCAGGAATATGTGACTATGTCTATGTCGAAACTAGGTCGGATATCACGTTTAGCAGCTGATTTAATAGGCAGTTCGTGGACCTTTGCCAGCTTGGAACAAGAAAGCGCTCCGGGACAGATTTCTTTGGCAGATATGCGTAAAATTAAGGAGGTTCTAGATGCAAATTGA","4.20","-17.50","25769","MKIVVPVMPQNIEEANQLDLTRIDSTDIIEWRADYLVKDDILTVAPAIFEKFSGHEVIFTLRTEKEGGNISLSNEDYLAIIRDIAALYQPDYIDFEYFSYRDVLEEMYDFSNLILSYHNFEETPENLMEVFSELTALAPRVVKIAVMPKNEQDVLDLMNYTRGFKTLNPNQEYVTMSMSKLGRISRLAADLIGSSWTFASLEQESAPGQISLADMRKIKEVLDAN","729583","For other 'aro' genes see SMu0706 (aroE); SMu0707 (aroB); SMu0708 (aroC); SMu0711 (aroA); SMu0712 (aroK); SMu1672 (aroG) and SMu1673 (aroH) (aroG).From Genbank:[gi:114188]This enzyme is involved in the biosynthesis of aromatic amino acids.","3-dehydroquinate dehydratase","Cytoplasm","Several matches in gapped BLAST to 3-dehydroquinate dehydratase: residues 1-223 are 68% similar to the enzyme in S.pneumoniae (gi|15901231|)and are 66% similar to the protein from S.pyogenes (gi|15674851|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1379 (2e-94).","

InterPro
IPR001381
Domain

Dehydroquinase class I
PD005337	$\"[116-220]T$	DHquinase_I
PF01487	$\"[3-218]T$	DHquinase_I
TIGR01093	$\"[2-219]T$	aroD

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[2-225]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR21088	$\"[1-225]T$	PTHR21088
SSF51569	$\"[1-225]T$	SSF51569

","BeTs to 7 clades of COG0710COG name: 3-dehydroquinate dehydrataseFunctional Class: EThe phylogenetic pattern of COG0710 is amt-yq--eb--------in-Number of proteins in this genome belonging to this COG is 1","***** IPB001381 (Dehydroquinase class I active site) with a combined E-value of 5.6e-31. IPB001381A 24-38 IPB001381B 56-68 IPB001381C 112-125 IPB001381D 143-154 IPB001381E 192-212","Residues 58-223 are 45% similar to a (3-DEHYDROQUINATE DEHYDRATASE LYASE ACID AMINO) protein domain (PD005337) which is seen in AROD_LACLA.Residues 2-57 are 42% similar to a (I AMINO LYASE TYPE) protein domain (PD384999) which is seen in AROD_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:38:54 2002","Tue Dec 18 09:04:27 2001","Sat Oct 12 10:38:54 2002","Tue Dec 18 08:56:16 2001","Tue Dec 18 08:56:16 2001","Tue Dec 18 08:56:16 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0705 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 08:56:39 2001","Tue Dec 18 08:56:16 2001","pdb|1QFE|A Chain A, The Structure Of Type I 3-Dehydroquinate De... 125 6e-030","SMU.777","","Residues 3 to 218 (E-value = 1.1e-40) place SMu0705 in the DHquinase_I family which is described as Type I 3-dehydroquinase (PF01487)","Tue Dec 18 08:56:16 2001","24379236","","","Servos,S., Chatfield,S., Hone,D., Levine,M.,Dimitriadis,G.,Pickard,D., Dougan,G., Fairweather,N. and Charles,I.Molecular cloning and characterization of the aroD gene encoding3-dehydroquinase from Salmonella typhiJ. Gen. Microbiol. 137 (Pt 1), 147-152 (1991)PubMed: 2045778Duncan,K., Chaudhuri,S., Campbell,M.S. and Coggins,J.R.The overexpression and complete amino acid sequence of Escherichiacoli 3-dehydroquinaseBiochem. J. 238 (2), 475-483 (1986)PubMed: 3541912Chaudhuri,S., Duncan,K., Graham,L.D. and Coggins,J.R.Identification of the active-site lysine residues of twobiosynthetic 3-dehydroquinasesBiochem. J. 275 (Pt 1), 1-6 (1991)PubMed: 1826831Deka,R.K., Kleanthous,C. and Coggins,J.R.Identification of the essential histidine residue at the activesite of Escherichia coli dehydroquinaseJ. Biol. Chem. 267 (31), 22237-22242 (1992)PubMed: 1429576","","Tue Dec 18 09:03:39 2001","1","","","SMU.777","581" "SMu0706","729574","730443","870","ATGCAAATTGATGGTTATACACGTTTAGCAGCTGTTGTCGCGACACCAATTAAACATTCTATCTCACCTTTTATTCACAACTACGCTTTTGAAAAAACTGGTATCAATGGTGTTTATGTTGCTTGGGATATTCCAGAGTCAGAACTGCAAGTAACTTTAAAAAATATCATGCGTTATGATATGTTTGGCATTAACATCTCCATGCCTTACAAGCAGGCAGTTATTCCTTATCTTGATGAAGTAACGAAAGCAGCAGATTTAATTGGGGCTGTTAATACTATTGTTAATCGTGATGGCAGATTGATCGGTTACAATACAGATGGTTTTGGTTTCTTTAAGAGTTTGGGAACCTTTGCAGATTTCGATGTTGCAGATAAGGTTATAACCATACTTGGTGGCGGAGGAGCTGCAACTGCCATTATTGCACAAGCAGCTATCAATGGTGCTAAGAAAATTAATATTTTTAATCAAACAGCCTTTCTTGAAGAAACAAAAGAAAAAGCTAAACAAATATCAAGTAAAACAGGCGCTGCTATTGAAGTGTTTCCTGTTGAGGACTTAAACATGATTCAAAAAAAGGTATTAGTATCTGATTTATTTGTTAATGCGACCAATGTTGGTATGGATGGCAAATCAATGATTATTAATGATAGTTTTGAATTTCCACCAAACCTTATGGTTGCAGATGTCATTTATCAACCTTTTGAAACACCATTTTTACGCTTAGTACGCAGTCGTGGGTTAAAGGCTGTGAATGGTTTGGGCATGCTTCTTTTTCAGGCGGCTGCAGCTTTTGAACTTTGGACTGGTAAAGAAATGCCGAGTCAGGAAATCTGGCAGGCTCTAGAAAAAAAATACAAGTCTAAATAA","6.60","-0.51","31797","MQIDGYTRLAAVVATPIKHSISPFIHNYAFEKTGINGVYVAWDIPESELQVTLKNIMRYDMFGINISMPYKQAVIPYLDEVTKAADLIGAVNTIVNRDGRLIGYNTDGFGFFKSLGTFADFDVADKVITILGGGGAATAIIAQAAINGAKKINIFNQTAFLEETKEKAKQISSKTGAAIEVFPVEDLNMIQKKVLVSDLFVNATNVGMDGKSMIINDSFEFPPNLMVADVIYQPFETPFLRLVRSRGLKAVNGLGMLLFQAAAAFELWTGKEMPSQEIWQALEKKYKSK","730442","For other 'aro' genes see SMu0705 (aroD); SMu0707 (aroB); SMu0708 (aroC); SMu0711 (aroA); SMu0712 (aroK); SMu1672 (aroG) and SMu1673 (aroH) (aroG).","shikimate 5-dehydrogenase","Membrane, Cytoplasm","Several matches in gapped BLAST to shikimate 5-dehydrogenase: residues 1-287 are 52% similar to the enzyme in S.pneumoniae (gi|15901230|). Residues 1-285 are 45% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673739|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1680 (9e-44).","

InterPro
IPR006151
Domain

Shikimate/quinate 5-dehydrogenase
PF01488	$\"[111-240]T$	Shikimate_DH

InterPro
IPR011342
Domain

Quinate/Shikimate 5-dehydrogenase
TIGR00507	$\"[8-287]T$	aroE

InterPro
IPR013708
Domain

Shikimate dehydrogenase substrate binding, N-terminal
PF08501	$\"[12-94]T$	Shikimate_dh_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.192.10	$\"[1-136]T$	G3DSA:3.40.192.10
PTHR21089	$\"[198-287]T$	PTHR21089
SSF51735	$\"[107-288]T$	SSF51735
SSF53223	$\"[1-106]T$	SSF53223

","BeTs to 12 clades of COG0169COG name: Shikimate 5-dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0169 is amt-yqvcEbrHuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB002907 (Shikimate / quinate 5-dehydrogenase) with a combined E-value of 4.1e-50. IPB002907A 12-39 IPB002907B 63-94 IPB002907C 101-110 IPB002907D 129-138 IPB002907E 195-208 IPB002907F 253-268","Residues 8-115 are 60% similar to a (SHIKIMATE 5-DEHYDROGENASE OXIDOREDUCTASE BIOSYNTHESIS) protein domain (PD120824) which is seen in AROE_LACLA.Residues 231-274 are 59% similar to a (SHIKIMATE 5-DEHYDROGENASE OXIDOREDUCTASE) protein domain (PD170736) which is seen in AROE_LACLA.Residues 165-229 are 41% similar to a (SHIKIMATE 5-DEHYDROGENASE AMINO NADP) protein domain (PD395533) which is seen in AROE_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:39:17 2002","Tue Dec 18 09:05:00 2001","Sat Oct 12 10:39:17 2002","Tue Dec 18 09:05:00 2001","Tue Dec 18 09:05:00 2001","Tue Dec 18 09:05:00 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0706 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 10:04:26 2001","","No significant hits to the NCBI PDB database.","SMU.778","","Residues 25 to 271 (E-value = 3.3e-70) place SMu0706 in the Shikimate_DH family which is described as Shikimate / quinate 5-dehydrogenase (PF01488)","Tue Dec 18 09:05:00 2001","24379237","","","","","","1","","","SMU.778","851" "SMu0707","730457","731524","1068","ATGAAATTAAACGTTAATCTTCCTCGTAAACCTTATGATATTATCATTGAAAAAGGTAGTTTGTCAAAAGTGGGACAATGGGTTAAGGAACTTTGGCAACCACAAAAAATTGCTTTAATAACAGATAACCGTGTAGGTAGTCTTTATGCTGAAAAAGTTAAACTTGGTCTTGAAGATGCTGGTTTTGAAATTGTTGTTTTTGACTTTTTGGAAGGTGAAGCCAGTAAAAATTTGACGACTGTCAATAAAGCCTATGAGTTTTTGCTCAAACAAGGTATGACAAGAAGCGATGGTATCATTGCTCTTGGCGGCGGTGTCGTTGGAGATTTGGCTGGATTTGTCGCTTCGACTTATATGCGCGGCATTCATTTTTTGCAAATTCCCACCAGTCTGACAGCGCAGGTAGATTCGTCCATAGGTGGTAAGACAGGTGTTAATACGCCTCTTGCGAAAAACATGGTGGGCACTTTTACTCAGCCAGATGGTGTCTTAATTGATCCAGATACACTCAATACACTTGGTAAGCGTGAACTTATTGAAGGTATGGGGGAAGTGATTAAATATGGTTTGATTGCTGATGTTGAATTATGGGAAATTCTAAAAGACTTAGATGGTTCAACAGACTCTATTTTAGAAAATGCTGAAAAGATTATTTATCATTCTTGCAATGTGAAGCGTCAGATTGTTGTTGAGGACGAATTGGATAATGGTGTTCGTCTTTACCTCAATTTTGGTCATACTATTGGTCATGCTATTGAAGCGACTGCAGGTTATGGCAAAGTGATGCATGGCGAAGCCGTGGCTATTGGGATGGTTCAGATTTCGCGTATTGCTGAGACAAAAGGACTCATGCTGCAAGGAATAACAGAAAAAATCGAGGCCATGTGTTTGAAATTTGGCTTACCTACTGACTATAGTCCGTGGAATGTTGAACCTATGTACCAAGCATTAAAGCATGATAAAAAAACGCGTGGCCAAATGATAAAAATGGTTGTTGTTCCCCAACTAGGACAGGCTGCTATCAATCAAATCAGCCTAGAAGAAATGAAAGAGTATTTGGAGAAGTGA","5.40","-6.62","39048","MKLNVNLPRKPYDIIIEKGSLSKVGQWVKELWQPQKIALITDNRVGSLYAEKVKLGLEDAGFEIVVFDFLEGEASKNLTTVNKAYEFLLKQGMTRSDGIIALGGGVVGDLAGFVASTYMRGIHFLQIPTSLTAQVDSSIGGKTGVNTPLAKNMVGTFTQPDGVLIDPDTLNTLGKRELIEGMGEVIKYGLIADVELWEILKDLDGSTDSILENAEKIIYHSCNVKRQIVVEDELDNGVRLYLNFGHTIGHAIEATAGYGKVMHGEAVAIGMVQISRIAETKGLMLQGITEKIEAMCLKFGLPTDYSPWNVEPMYQALKHDKKTRGQMIKMVVVPQLGQAAINQISLEEMKEYLEK","731523","For other 'aro' genes see SMu0705 (aroD); SMu0706 (aroE); SMu0708 (aroC); SMu0711 (aroA); SMu0712 (aroK); SMu1672 (aroG) and SMu1673 (aroH) (aroG).","3-dehydroquinate synthase","Cytoplasm","Several matches in gapped BLAST to 3-dehydroquinate synthase: residues 1-355 are 71% similar to the enzyme in S.pneumoniae (gi|15903276|)and are 63% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673738|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1378 (1e-126).","

InterPro
IPR002658
Domain

3-dehydroquinate synthase AroB
PF01761	$\"[16-324]T$	DHQ_synthase
TIGR01357	$\"[12-354]T$	aroB

noIPR
unintegrated

unintegrated
G3DSA:1.20.1090.10	$\"[173-351]T$	G3DSA:1.20.1090.10
G3DSA:3.40.50.1970	$\"[7-172]T$	G3DSA:3.40.50.1970
PTHR21090	$\"[71-355]T$	PTHR21090
PTHR21090:SF1	$\"[71-355]T$	PTHR21090:SF1
SSF56796	$\"[1-355]T$	SSF56796

","BeTs to 8 clades of COG0337COG name: 3-dehydroquinate synthetaseFunctional Class: EThe phylogenetic pattern of COG0337 is ----y-vcebrhuj----in-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 35-345 are 63% similar to a (SYNTHASE 3-DEHYDROQUINATE DEHYDROGENASE LYASE PROTEOME) protein domain (PD002227) which is seen in AROB_LACLA.Residues 1-33 are 63% similar to a (AMINO LYASE 3-DEHYDROQUINATE SYNTHASE) protein domain (PD371591) which is seen in AROB_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:39:38 2002","Tue Dec 18 10:12:25 2001","Sat Oct 12 10:39:38 2002","Tue Dec 18 10:12:25 2001","","Tue Dec 18 10:12:25 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0707 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 10:14:17 2001","Tue Dec 18 10:12:25 2001","pdb|1DQS|B Chain B, Crystal Structure Of Dehydroquinate Synthas... 162 8e-041","SMU.779","","Residues 11 to 349 (E-value = 5.9e-05) place SMu0707 in the Fe-ADH family which is described as Iron-containing alcohol dehydrogenase (PF00465)Residues 15 to 354 (E-value = 1.6e-111) place SMu0707 in the DHQ_synthase family which is described as 3-dehydroquinate synthase (PF01761)","Tue Dec 18 10:12:25 2001","24379238","","","Barten,R. and Meyer,T.F.Cloning and characterisation of the Neisseria gonorrhoeae aroB geneMol. Gen. Genet. 258 (1-2), 34-44 (1998)PubMed: 9613570","","Tue Dec 18 10:18:02 2001","1","","","SMU.779","414" "SMu0708","731526","732692","1167","ATGAGATATTTTACAGCTGGGGAATCGCATGGTCCTCGTCTGACAGCTATTATTGAAGGAGTGCCAGCAGGTCTTCCTCTAACAGCCGACTATATTAATGCTGAATTAAGGCGGCGGCAAGGAGGTTATGGTCGTGGCGGCCGTATGAAGATTGAATCTGATCAAGTGGAAATCACTTCAGGTGTTCGCCATGGTTTGACTATGGGAAGTCCGATTACACTCAATGTCACTAATCGTGATTTTAAAAATTGGACTGAAATCATGAGTGCTGCTGATATTGAGGATAAGAAAAAATCAATTCGAAAATTAACCAAACCCCGTCCGGGACATGCAGATTTGGTTGGTGGTATGAAATATCGTTTTTCTGATTTGCGCAACAGTTTGGAGCGCTCAAGTGCGCGTGAAACAACTATGCGTGTGGCAGTGGGATCAGTAGCTAAACGTCTTTTAGAAGAACTTGAGATAACTATTGCTAGCCACGTTGTTGTTTTGGGCGGCATTGAAGTTGATGTTCCTGAAAATCTGACAGTAGCTGAGATTAAAGAACGAGCAAGTCAATCTGAAATTTCCGTTGTTAACCAAGAACATGAGCAAGAAATCAAGGATTATATTGATCAGATTAAAAAAGAAGGCAACACTATCGGCGGTATTATTGAAACTGTTGTTGGTGGTGTTCCAGTTGGTTTAGGCTCTTATGTTCAATGGGATCGCAAATTAGATGCCCAAATAGCTCAAGGAGTTGTTTCCATCAATGCCTTCAAGGGTGTTGAATTTGGCTTAGGCTTTAAGGATGGTTATCTCAAAGGCAGCTATGTCATGGATGAGATTACTTGGTCTAAAGAAGATGGCTATAGGCGTAAGTCCAACAATCTTGGTGGTTTTGAAGGCGGTATGACTAATGGACAGCCTATTGTTGTTCGTGGGGTTATGAAGCCTATTCCGACACTTTATAAGCCTTTGATGAGTGTTGATATTGAAACACACGAACCATATAAGGCCAGTGTTGAACGTTCGGACCCAACAGCTGTTCCCGCCGCTGCAGTAGTTATGGAAGGAGTCGTTGCGACAGTTTTAGCAACAGAAATTTTGAATAAGTTTTCTTCAGATAATATGGAAGAGCTAAAAGAAGCTGTGAAAAGCCATCAAAAATTTATCAAAGAATTTTAA","6.70","-1.27","42629","MRYFTAGESHGPRLTAIIEGVPAGLPLTADYINAELRRRQGGYGRGGRMKIESDQVEITSGVRHGLTMGSPITLNVTNRDFKNWTEIMSAADIEDKKKSIRKLTKPRPGHADLVGGMKYRFSDLRNSLERSSARETTMRVAVGSVAKRLLEELEITIASHVVVLGGIEVDVPENLTVAEIKERASQSEISVVNQEHEQEIKDYIDQIKKEGNTIGGIIETVVGGVPVGLGSYVQWDRKLDAQIAQGVVSINAFKGVEFGLGFKDGYLKGSYVMDEITWSKEDGYRRKSNNLGGFEGGMTNGQPIVVRGVMKPIPTLYKPLMSVDIETHEPYKASVERSDPTAVPAAAVVMEGVVATVLATEILNKFSSDNMEELKEAVKSHQKFIKEF","732691","For other 'aro' genes see SMu0705 (aroD); SMu0706 (aroE); SMu0707 (aroB); SMu0711 (aroA); SMu0712 (aroK); SMu1672 (aroG) and SMu1673 (aroH) (aroG).From Genbank: [gi:12407965]This enzyme catalyzes the seventh step in the biosynthesisof chorismate within the aromatic amino acid biosyntheticpathway (Shikimate pathway).","chorismate synthase","Cytoplasm","Several matches in gapped BLAST to chorismate synthase: residues 1-388 are 73% similar to the enzyme in S.pneumoniae (gi|15901228|) and are 67% similar to the protein from Lactococcus lactis subsp.lactis (gi|15673734|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1377 (1e-148).","

InterPro
IPR000408
Repeat

Regulator of chromosome condensation, RCC1
PS00626	$\"[58-68]F$	RCC1_2

InterPro
IPR000453
Family

Chorismate synthase
PD002941	$\"[30-355]T$	Chorismate_synth
PTHR21085	$\"[1-388]T$	Chorismate_synth
PF01264	$\"[1-366]T$	Chorismate_synt
TIGR00033	$\"[1-369]T$	aroC
PS00787	$\"[7-22]T$	CHORISMATE_SYNTHASE_1
PS00788	$\"[129-145]T$	CHORISMATE_SYNTHASE_2
PS00789	$\"[337-353]T$	CHORISMATE_SYNTHASE_3

noIPR
unintegrated

unintegrated
SSF103263	$\"[1-388]T$	SSF103263

","BeTs to 12 clades of COG0082COG name: Chorismate synthaseFunctional Class: EThe phylogenetic pattern of COG0082 is amt-yqvcebrhuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB000453 (Chorismate synthase) with a combined E-value of 6.1e-104. IPB000453A 1-42 IPB000453B 48-72 IPB000453C 107-135 IPB000453D 238-274 IPB000453E 288-316 IPB000453F 336-360","Residues 2-362 are 68% similar to a (CHORISMATE SYNTHASE LYASE BIOSYNTHESIS) protein domain (PD002941) which is seen in AROC_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:39:58 2002","Tue Dec 18 10:42:34 2001","Sat Oct 12 10:39:58 2002","Tue Dec 18 10:32:56 2001","Tue Dec 18 10:32:56 2001","Tue Dec 18 10:32:56 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0708 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 10:33:18 2001","","No significant hits to the NCBI PDB database.","SMU.780","","Residues 1 to 366 (E-value = 5e-161) place SMu0708 in the Chorismate_synt family which is described as Chorismate synthase (PF01264)","Tue Dec 18 10:32:56 2001","24379239","","","Horsburgh,M.J., Foster,T.J., Barth,P.T. and Coggins,J.R.Chorismate synthase from Staphylococcus aureusMicrobiology 142 (Pt 10), 2943-2950 (1996)PubMed: 8885411","","Tue Dec 18 10:41:11 2001","1","","","SMU.780","413" "SMu0709","732756","733862","1107","ATGGAAGAAAAAACAATTTATATTGCAGGACTAGGACTAATTGGTGCTTCGCTTGCTTTGGGAATAAAACGAGATCATCCTCATTATAAGATCGTTGGTTACAATCGTTCTGATAGGTCACGTGATATTGCACTTGAGCGCGGAATTGTTGATGAGGCGACAGCTGATTTTAAAGTATTTGCTGCTTTGGCAGATGTCATTATCTTGGCAGTACCTATTAAAAAAACAATTGATTTTATCAAAATTTTAGCAGATTTGGATTTAAAAGAAGATGTCATTATTACAGATGCCGGCTCTACTAAATATGAAATTGTTAGAGCTGCAGAATATTATCTTAAAGATAAGCCTGTGCAATTTGTAGGCAGTCATCCTATGGCTGGAAGTCATAAATCAGGAGCTGTTGCGGCAAATGTCAATCTTTTTGAGAATGCTTATTATATTTTTTCACCATCATGTCTAACTAAACCTAATACTATTCCTGCCTTGCAGGATCTTTTATCAGGCTTGCATGCTAGGTATGTGGAAATTGATGCGGCAGAACATGACTGCGTTACGAGTCAAATTAGTCATTTTCCGCATATTATCGCCTCGAGTCTTATGAAGCAGGCCGGTGACTTTTCAGAAAGTCATGAAATGACCAAGCATTTTGCTGCGGGTGGTTTTCGTGATATGACCCGAATTGCTGAAAGTGAACCCGGCATGTGGACTAGTATTCTTTTGACCAATCAAGAGGCCGTTTTAGATCGTATTGAAAATTTTAAGCAGCGTCTAGATGAGGTTTCTAATTTGATTAAGGCTAGAGATGAAAATGCTATTTGGGCGTTTTTTAATCAAAGCCGGCAAATCCGTAAAAATATGGAAATTCATAAGCGTGCTGGTGTCGATAGCTTTTATGATATTTATGTTGATGTTCCTGATGAAGAAAATGTTATTTTGGAAATCCTCGAATTACTGAGAGGAACCTCTCTGGTCAATGTTCATATCAATGAAGAGAACCGAGAAGATATTAATGGTATCTTACAGATTTCTTTCAAAAATGAGCGTGATTTAAAACGTGCTCAGGAATTGATTCGTAAAAATACTAATTATCGTGTTTATTTAAATTAA","5.80","-8.17","41570","MEEKTIYIAGLGLIGASLALGIKRDHPHYKIVGYNRSDRSRDIALERGIVDEATADFKVFAALADVIILAVPIKKTIDFIKILADLDLKEDVIITDAGSTKYEIVRAAEYYLKDKPVQFVGSHPMAGSHKSGAVAANVNLFENAYYIFSPSCLTKPNTIPALQDLLSGLHARYVEIDAAEHDCVTSQISHFPHIIASSLMKQAGDFSESHEMTKHFAAGGFRDMTRIAESEPGMWTSILLTNQEAVLDRIENFKQRLDEVSNLIKARDENAIWAFFNQSRQIRKNMEIHKRAGVDSFYDIYVDVPDEENVILEILELLRGTSLVNVHINEENREDINGILQISFKNERDLKRAQELIRKNTNYRVYLN","733861","For other 'tyr' genes see SMu1809 (tyrS).","prephenate dehydrogenase","Cytoplasm","Several matches in gapped BLAST to prephenate dehydrogenase: residues 23-367 are 67% similar to the enzyme in S.pneumoniae (gi|15903274|)and are 51% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673727|).SMu0709 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003099
Domain

Prephenate dehydrogenase
PF02153	$\"[8-283]T$	PDH
PS51176	$\"[4-294]T$	PDH_ADH

InterPro
IPR008236
Family

Predicted prephenate dehydrogenase, feedback inhibition-sensitive
PIRSF005547	$\"[3-368]T$	PDH_fbk_sens

noIPR
unintegrated

unintegrated
PTHR21363	$\"[1-360]T$	PTHR21363
SSF51735	$\"[4-178]T$	SSF51735

","BeTs to 9 clades of COG0287COG name: Prephenate dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0287 is amt-yqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 72-278 are 55% similar to a (DEHYDROGENASE PREPHENATE PROTEOME) protein domain (PD356257) which is seen in Q9CET9_LACLA.Residues 280-365 are 48% similar to a (PREPHENATE DEHYDROGENASE PROTEOME) protein domain (PD039469) which is seen in Q9CET9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:40:43 2002","Tue Dec 18 10:43:51 2001","Sat Oct 12 10:40:43 2002","Tue Dec 18 10:43:51 2001","","Tue Dec 18 10:43:51 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0709 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 10:54:27 2002","","No significant hits to the NCBI PDB database.","SMU.781","","Residues 8 to 283 (E-value = 6.7e-104) place SMu0709 in the PDH family which is described as Prephenate dehydrogenase (PF02153)","Tue Dec 18 10:43:51 2001","24379240","","","Henner,D.J., Band,L., Flaggs,G. and Chen,E.The organization and nucleotide sequence of the Bacillus subtilishisH, tyrA and aroE genesGene 49 (1), 147-152 (1986)PubMed: 3106153","","Tue Dec 18 10:50:54 2001","1","","","SMU.781","" "SMu0710","733873","734214","342","ATGACAGTAAATGTATATGATTTAGCAAATGAGTTGGAGCGCGGTATTCGTGCTTTACCAGAATATCAAGCCCTTGTCCAAGCAAAAGCTAAGATTGACGAAGATGAAGAGGCTAAGAAATTGTGGACTGAATTCACAGAATTTCAAATGAAAATTCAAGGCCTCATACAAACAGGACAAGCACCAACTCCTGAGGTTCAAACGGAAATGCAAAGTTTTAATCAAAAAATTGAAGCTAATCCACTTTTAAAAGAATATGCTACAGCTCAACAAGCTCTTGGAGTTTATGTCAATGATATCGAACGCATTATTTTTTCACCTTTACAAGATATTGCCAAATGA","4.40","-7.00","12872","MTVNVYDLANELERGIRALPEYQALVQAKAKIDEDEEAKKLWTEFTEFQMKIQGLIQTGQAPTPEVQTEMQSFNQKIEANPLLKEYATAQQALGVYVNDIERIIFSPLQDIAK","734213","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-113 are 51% similar to the protein in S.pyogenes (gi|15674853|). Residues 4-113 are 42% similar to the protein from S.pneumoniae (gi|15903273|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1376 (8e-28).","

InterPro
IPR010368
Family

Protein of unknown function DUF964
PF06133	$\"[4-111]T$	DUF964

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-111 are 27% similar to a (PROTEOME COMPLETE BH1149) protein domain (PD075603) which is seen in O87558_BACFI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 11:10:26 2002","Tue Dec 18 10:54:37 2001","Thu Jan 24 11:10:26 2002","Tue Dec 18 10:54:07 2001","","Tue Dec 18 10:54:07 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0710 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 10:54:37 2001","","No significant hits to the NCBI PDB database.","SMU.782","","Residues 4 to 111 (E-value = 4.3e-71) place SMu0710 in the DUF964 family which is described as Protein of unknown function (DUF964) (PF06133)","Tue Dec 18 10:54:07 2001","24379241","","","","","","1","","","SMU.782","943" "SMu0711","734377","735660","1284","ATGAAATTACGAACAAATGCTTCAGGTCTGAGCGGAACATTGAAAATTCCCGGCGATAAGTCTATCAGTCATCGCTCGATTATGTTTGGCAGTCTGGCAAAGGGGATAACGAAAATCTATGGTATTTTACGCGGTGAGGATGTTTTATCAACAATGCAGGCCTTTCGTGACTTAGGTGTTGAAATTAAAGATAAGGATGATTTCGTTGAGATACACGGTCGTGGTTTTGACGGTCTCAAATCTCCTAAAAAAGCTCTTGATATGGGTAATTCAGGAACGTCTATTCGTTTAATTTCAGGAGTTTTAGCTGGACAAGATTTTACAGTCGAAATGTTTGGGGATGACAGTCTGTCTAAACGTCCTATGGATAGGGTAACGGTTCCTCTTCGTCAAATGGGAGTCCAAATTTTGGGGCGGACAGAGCGCGATTTGCCTCCTTTGACAATGAAAGGTTCAAAAAGATTAAAACCAATCCGTTATGAACTTCCTGTTGCTTCGGCGCAAGTTAAATCGGCTCTTATTTTTGCAGCTCTTCAAGCTTCTGGCGAGAGCGTCATTATTGAAAAAGAGAAAACGCGAAATCATACAGAAGATATGATTAAACAATTTGGAGGTCATCTTGATGTGGATGGCAAAGAAATCCGCATTTCAGGTGGACAGGAATTCACAGCACAGAATGTTATTGTCCCTGGTGATATTTCAAGTGCGGCTTTCTGGCTGGCTGCAGGACTTATTGTTTCAAACAGTAAGCTTACTCTAAAAAATGTCGGCATTAATGAAACACGCACAGGTATTTTAGAAGTTATTGAAGCTATGGGTGGTAAAGTTGAACTGAGCGATAGGGATGACTTAGCAAAAGCAGCGACCCTTACTGTTGAAAGTTCTAATCTTAAAGGAACAGAAATTGGCGGTGACATTATTCCACGGCTGATTGATGAACTGCCTATTATTGCTCTTTTGGCAACACAGGCAAATGGCCGAACTGTTATTTATGATGCCCAAGAGCTCAAGGTTAAAGAGACAGATCGTATTCAGGTAGTAGCAGACGCTTTAAATGCTATGGGGGCTAAGATAACTCCAACAGATGATGGCATGATTATTGAAGGTAAAACCAATCTTCATGGTGCTAAGGTCAATACTTTTGGCGATCATCGGATTGGTATGATGACGGCTATTGCGGCACTTTTGGTTAAAGAGGGAGAAGTTGAATTAGAGCGTGCTGAAGCGATCAATACCAGCTACCCTACTTTCTTTAGTGATTTAGAAAGGATAACGAATGGCTAA","6.30","-2.52","46077","MKLRTNASGLSGTLKIPGDKSISHRSIMFGSLAKGITKIYGILRGEDVLSTMQAFRDLGVEIKDKDDFVEIHGRGFDGLKSPKKALDMGNSGTSIRLISGVLAGQDFTVEMFGDDSLSKRPMDRVTVPLRQMGVQILGRTERDLPPLTMKGSKRLKPIRYELPVASAQVKSALIFAALQASGESVIIEKEKTRNHTEDMIKQFGGHLDVDGKEIRISGGQEFTAQNVIVPGDISSAAFWLAAGLIVSNSKLTLKNVGINETRTGILEVIEAMGGKVELSDRDDLAKAATLTVESSNLKGTEIGGDIIPRLIDELPIIALLATQANGRTVIYDAQELKVKETDRIQVVADALNAMGAKITPTDDGMIIEGKTNLHGAKVNTFGDHRIGMMTAIAALLVKEGEVELERAEAINTSYPTFFSDLERITNG","735659","For other 'aro' genes see SMu0705 (aroD); SMu0706 (aroE); SMu0707 (aroB); SMu0708 (aroC); SMu0712 (aroK); SMu1672 (aroG) and SMu1673 (aroH) (aroG).","3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase)","Cytoplasm, Membrane","Several matches in gapped BLAST to 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase): residues 1-427 are 68% similar to the enzyme in Lactococcus lactis subsp. lactis (gi15673726). Residues 1-425 are 59% similar to the protein from S.pneumoniae (gi15902045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0630 (1e-163).","

InterPro
IPR001986
Domain

3-phosphoshikimate 1-carboxyvinyltransferase
PD001867	$\"[10-395]T$	EPSP_synth
G3DSA:3.65.10.10	$\"[3-207]T$ $\"[214-427]T$	EPSP_synthase
PF00275	$\"[4-421]T$	EPSP_synthase
PS00104	$\"[86-100]T$	EPSP_SYNTHASE_1
PS00885	$\"[337-355]T$	EPSP_SYNTHASE_2

InterPro
IPR006264
Domain

3-phosphoshikimate 1-carboxyvinyltransferase, subgroup
TIGR01356	$\"[12-427]T$	aroA

InterPro
IPR013792
Domain

RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
SSF55205	$\"[1-424]T$	RNA3'_cycl/enolpyr_transf_A/B

noIPR
unintegrated

unintegrated
PIRSF000505	$\"[1-427]T$	EPSPS
PTHR21090	$\"[1-361]T$	PTHR21090
PTHR21090:SF5	$\"[1-361]T$	PTHR21090:SF5

","BeTs to 12 clades of COG0128COG name: 5-enolpyruvylshikimate-3-phosphate synthaseFunctional Class: EThe phylogenetic pattern of COG0128 is amt-yqvcebrhuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB001986 (EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)) with a combined E-value of 7.9e-50. IPB001986A 12-52 IPB001986B 86-96 IPB001986C 110-136 IPB001986D 166-178 IPB001986F 229-241 IPB001986H 317-369 IPB001986I 380-392","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 17:56:23 2006","Tue Dec 18 10:58:27 2001","Thu Sep 7 17:56:23 2006","Tue Dec 18 10:56:54 2001","Tue Dec 18 10:56:54 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0711 is paralogously related (blast p-value < 1e-3) to SMu1429, a predicted UDP-N-acetylglucosamine 1-carboxyvinyltransferase.","Thu Jan 24 11:12:21 2002","Thu Sep 7 17:56:23 2006","pdb1G6SA Chain A, Structure Of Epsp Synthase Liganded With Sh... 131 2e-031pdb1EPS 5-Enol-Pyruvyl-3-Phosphate Synthase (E.C.2.5.1.9) 129 8e-031","SMU.784","","Residues 6 to 421 (E-value = 1.5e-159) place SMu0711 in the EPSP_synthase family which is described as EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (PF00275)","Tue Dec 18 10:56:54 2001","24379242","","","Du,W., Wallis,N.G., Mazzulla,M.J., Chalker,A.F., Zhang,L., Liu,W.S., Kallender,H. and Payne,D.J.Characterization of Streptococcus pneumoniaev 5-enolpyruvylshikimate 3-phosphate synthase and its activation by univalent cationsEur. J. Biochem. 267 (1), 222-227 (2000)PubMed: 10601870Griffin,H.G. and Gasson,M.J.Genetic aspects of aromatic amino acid biosynthesis in LactococcuslactisMol. Gen. Genet. 246 (1), 119-127 (1995)PubMed: 7823907","","Tue Dec 18 12:10:23 2001","1","","","SMU.784","302" "SMu0712","735653","736129","477","ATGGCTAAAATTTTAATCGGTTTTATGGGGGCAGGAAAATCAACTGTTTCCCGTTTATTAGACCCGGATTTTCAAGATATGGATGATATTATAACTGAGAAAATTGGAATGCCTATTGCAGCATTTTTTGAAAAAGAAGGTGAGGATGCCTTTCGGGAAATTGAGTCTGAAACCTTATCCAATCTTGCTGATTCAGATAGTACTGTATCAACTGGAGGCGGTGTTGTTGAGAGTGCTCGCAATCGTGATATTTTGGCAAAAAATGGTGAAACAATTTATTTAAAAGCAGATTTTGAAACTCTTTGTAAGCGAATTGAAGCAGACAGTAATAACGTTCGGCCACTTTTTATTAATAATAGCCGTCAGGAATTTAAAAAGATTTTCGATCGCAGACAGGCTCTCTATGAGGAAGCCGCTAATATTATTATTGATGTTGCTGGTAAAACACCCCAAGAAATTGTTGAGGAAATAAAATGA","4.40","-10.04","17596","MAKILIGFMGAGKSTVSRLLDPDFQDMDDIITEKIGMPIAAFFEKEGEDAFREIESETLSNLADSDSTVSTGGGVVESARNRDILAKNGETIYLKADFETLCKRIEADSNNVRPLFINNSRQEFKKIFDRRQALYEEAANIIIDVAGKTPQEIVEEIK","736128","For other 'aro' genes see SMu0705 (aroD); SMu0706 (aroE); SMu0707 (aroB); SMu0708 (aroC); SMu0711 (aroA); SMu1672 (aroG) and SMu1673 (aroH) (aroG).","shikimate kinase","Cytoplasm","Several matches in gapped BLAST to shikimate kinase: residues 1-158 are 57% similar to the enzyme in S.pneumoniae (gi|15901224|)and are 44% similar to the protein from Lactococcus lactis (gi|1168516|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0631 (4e-30).","

InterPro
IPR000623
Domain

Shikimate kinase
PR01100	$\"[3-18]T$ $\"[23-36]T$ $\"[51-59]T$ $\"[68-77]T$ $\"[89-106]T$	SHIKIMTKNASE
PF01202	$\"[9-158]T$	SKI

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-157]T$	G3DSA:3.40.50.300
PTHR21087	$\"[4-157]T$	PTHR21087
SSF52540	$\"[5-158]T$	SSF52540

","BeTs to 9 clades of COG0703COG name: Shikimate kinaseFunctional Class: EThe phylogenetic pattern of COG0703 is ----yqvcEBrhuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB000623 (Shikimate kinase) with a combined E-value of 7.1e-19. IPB000623A 3-32 IPB000623B 47-62 IPB000623C 68-82 IPB000623D 111-117 IPB000623E 127-137","Residues 4-144 are 45% similar to a (KINASE SHIKIMATE TRANSFERASE ACID) protein domain (PD004326) which is seen in AROK_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","Tue Dec 18 12:11:47 2001","","","Sat Oct 12 10:41:33 2002","Tue Dec 18 12:11:47 2001","Sat Oct 12 10:41:33 2002","Tue Dec 18 12:11:47 2001","Tue Dec 18 12:11:47 2001","Tue Dec 18 12:11:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0712 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 12:13:33 2001","Tue Dec 18 12:11:47 2001","pdb|1SHK|A Chain A, The Three-Dimensional Structure Of Shikimat... 80 1e-016pdb|2SHK|B Chain B, The Three-Dimensional Structure Of Shikimat... 79 3e-016pdb|1SHK|B Chain B, The Three-Dimensional Structure Of Shikimat... 78 4e-016","SMU.785","","Residues 1 to 158 (E-value = 6.8e-45) place SMu0712 in the SKI family which is described as Shikimate kinase (PF01202)","Tue Dec 18 12:11:47 2001","24379243","","","Griffin,H.G. and Gasson,M.J.Genetic aspects of aromatic amino acid biosynthesis in LactococcuslactisMol. Gen. Genet. 246 (1), 119-127 (1995)PubMed: 7823907","","Tue Dec 18 12:14:39 2001","1","","","SMU.785","911" "SMu0713","736126","736950","825","ATGAAAATTGCTTATTTAGGGCCTAGCGGCTCTTTTACTCATAATGTCGCTTTGCATGCATTTCCTGCGGCAGATTTGCTTCCTTTTGAAAATATTACTGAAGTTATTAAGGCTTATGAGTCCAAACAGGTTTGTTTTGCCATTGTTCCGGTAGAAAATTCTATTGAAGGCAGTGTTCATGAAACCTTTGATTACCTTTTTCATCAGGCAAAAATAGAAGCAGTCGCTGAAATTATTCTTCCTATTAAGCAACAGCTAATGTCAACTTCTGCTGATAAAACAATTGAGACAATTTTTTCGCATCCTCAAGCCATTGCTCAAGGCAAACAGTATATTCGTTCTCACTATCCAGATGTCAAAATTGAAATGACTGCCAGCACTGCCTATGCCGCTCGTTTTGTGGCAGAACATCCTGAAGAGAATTACGCAGCCATTGCACCGTATGCTGCTGCAGATGAATATCATTTATCCATTATTGCCAAAGATATTCAAGAAATTGATGAAAATTATACCCGATTTTGGGTTTTAGGGGATGAAACCCCCACCATTCATCTAAAAGAGGAGGATCAAAAAATTTCTTTAGCTTTAACGCTTCCTGATAATTTACCCGGAGCGCTTTATAAAGCCCTTTCTACTTTTGCTTGGCGAGGGATTGATTTAACAAAAATTGAAAGCCGTCCCTTAAAAACGATTCTTGGAGAATACTTCTTTATTATTGATTTTGAGAATCATAATGAAAAATTAGTTTCTTTTGCACTAGAAGAGTTGACAAGTATTGGAATTCATTATAAAATTTTGGGTAAGTATGCCGTTTACAGGCTTTAA","5.20","-11.38","30915","MKIAYLGPSGSFTHNVALHAFPAADLLPFENITEVIKAYESKQVCFAIVPVENSIEGSVHETFDYLFHQAKIEAVAEIILPIKQQLMSTSADKTIETIFSHPQAIAQGKQYIRSHYPDVKIEMTASTAYAARFVAEHPEENYAAIAPYAAADEYHLSIIAKDIQEIDENYTRFWVLGDETPTIHLKEEDQKISLALTLPDNLPGALYKALSTFAWRGIDLTKIESRPLKTILGEYFFIIDFENHNEKLVSFALEELTSIGIHYKILGKYAVYRL","736949","For other 'phe' genes see SMu1788 (pheT); SMu1178 (pheA); SMu1367 (pheT); SMu1372 (pheT) and SMu1374 (pheS).","prephenate dehydratase","Cytoplasm, Membrane","Several matches in gapped BLAST to prephenate dehydratase: residues 1-272 are 64% similar to the enzyme in S.pneumoniae (gi|15903270|). Residues 1-274 are 50% similar to the protein from Lactococcus lactis subsp.lactis (gi|15673724|).SMu0713 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001086
Domain

Prephenate dehydratase
PF00800	$\"[3-181]T$	PDT
PS00858	$\"[220-227]T$	PREPHENATE_DEHYDR_2
PS51171	$\"[2-178]T$	PREPHENATE_DEHYDR_3

InterPro
IPR008237
Family

Prephenate dehydratase with ACT region
PIRSF001424	$\"[1-274]T$	PDT

noIPR
unintegrated

unintegrated
PTHR21022	$\"[1-274]T$	PTHR21022
SSF55021	$\"[173-273]T$	SSF55021

","BeTs to 10 clades of COG0077COG name: Prephenate dehydrataseFunctional Class: EThe phylogenetic pattern of COG0077 is amt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001086 (Prephenate dehydratase (PDT)) with a combined E-value of 1.2e-68. IPB001086A 3-15 IPB001086B 45-66 IPB001086C 76-87 IPB001086D 95-112 IPB001086E 143-176 IPB001086F 192-244","Residues 3-274 are 50% similar to a (DEHYDRATASE CHORISMATE PREPHENATE PHENYLALANINE) protein domain (PD002231) which is seen in Q9CEU2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:41:54 2002","Tue Dec 18 12:20:21 2001","Sat Oct 12 10:41:54 2002","Tue Dec 18 12:20:21 2001","Tue Dec 18 12:20:21 2001","Tue Dec 18 12:20:21 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0713 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 11:13:10 2002","","No significant hits to the NCBI PDB database.","SMU.786","","Residues 3 to 181 (E-value = 2.7e-68) place SMu0713 in the PDT family which is described as Prephenate dehydratase (PF00800)Residues 192 to 267 (E-value = 9.3e-08) place SMu0713 in the ACT family which is described as ACT domain (PF01842)","Tue Dec 18 12:20:21 2001","24379244","","","","","","1","","","SMU.786","" "SMu0714","736995","738383","1389","ATGAGCAGAAACAATAAGGGGAAAGTAAGCCGTCACGAGCAGTTACGCTATGAGTACCTCTTAAGAAATATAGCCTACCTCAGTCCTCGAGAGCAGGCTGAATTCGACTATCTTAAAAAGAAGGTTGAAATTCAAGAGACGCCTTCTTACTATTACGATGAACCTGGGGATAACTATTATCAAGATTATGAGCAGTCTTATGATAATAACTATGAAGATGATTATCAGGATGCTGACCAGTGGGATGATTATTATGCAAATAGTCATTATACTGATCAAGGATTGCCTGTTTATCCTGAGCAACAATCCACACGTTCTCAAAGGAAAAGCCATCAAGGAAAAAGAAAAGATTCCGTTTCGGCAACTAAGCCTAAAAAGCGCCGCCGCTGGACTGTTAAGCGCACTTTGAAGGCTGTTTGCTTGTTATTGCTAGTTATTTTTGCTGGTATGATTGTTATGTTTATCAAAGGCATGAATGATATTTCTTCCGGCAAAAATAAAAATTATAAACCAGCTGTTGTTGAAAAATTTAATGGAAAGAATACCAAAGATGGAACCAATATTCTAGTGTTAGGAAGCGATCAGCGTATTACACAAGGGTCATCAGAAGCGCGGACGGATACCATTATGGTTTTAAATGTCGGTAATAAAGACAAGAAGATTAAAATGGTTAGTTTTATGCGTGATACATTGGTCAATATTAAAGGGGTCAGCGCAGATAATTACTCATATGACAATAAATTAAATTCAGCATTTAATATTGGTGAACAAGATAACAATCAAGGCGCTGAGCTGATGCGGCAAACCTTGAAGCGTAATTTTGATATAGATATCAAATATTATGTCATGGTTGATTTTCAAACCTTTGCTGAGGCCATTGATACGCTTTTCCCTAATGGTGTTGAAATTAATGCAAAGTTTGCAACGGTCGGTGGTGAAGCCGTTGATTCAGTAGAGGTACCAGATGATCTTAATATGAAAGATGGTGTTGTTCCTAATCAAACGATTTCTGTTGGTAAGCAAAAGATGGATGGACGAACTTTGTTGAATTATGCCCGTTTTCGTAAGGATGATGAAGGCGACTTTGGACGAACGAAACGTCAGCAGCAGGTTATGTCGGCAATCATGTCTCAAATTAAAGATCCAACCAAGCTCTTTACAGGTTCTGCTGCCTTAGGTAAGATTTATGCTTTGACATCAACCAATATTTCTTATGGTTTTCTCTTGAGTCATGGCTTATCCGTTTTGACCAATGGCAAGAAAGTTGAACAGGTCACTGTTCCTGATAATGGGGATTGGATTGATGATTATGATATTTATGGTGGTCAGGCTCTGTCTATTGACTTTGACAAGTATAAAAAGAAATTAGCCCATTTAGGCGTTCGTTAA","9.40","5.19","52719","MSRNNKGKVSRHEQLRYEYLLRNIAYLSPREQAEFDYLKKKVEIQETPSYYYDEPGDNYYQDYEQSYDNNYEDDYQDADQWDDYYANSHYTDQGLPVYPEQQSTRSQRKSHQGKRKDSVSATKPKKRRRWTVKRTLKAVCLLLLVIFAGMIVMFIKGMNDISSGKNKNYKPAVVEKFNGKNTKDGTNILVLGSDQRITQGSSEARTDTIMVLNVGNKDKKIKMVSFMRDTLVNIKGVSADNYSYDNKLNSAFNIGEQDNNQGAELMRQTLKRNFDIDIKYYVMVDFQTFAEAIDTLFPNGVEINAKFATVGGEAVDSVEVPDDLNMKDGVVPNQTISVGKQKMDGRTLLNYARFRKDDEGDFGRTKRQQQVMSAIMSQIKDPTKLFTGSAALGKIYALTSTNISYGFLLSHGLSVLTNGKKVEQVTVPDNGDWIDDYDIYGGQALSIDFDKYKKKLAHLGVR","738382","","transcriptional regulator, Psr-like protein","Periplasm, Membrane, Extracellular","Several matches in gapped BLAST to transcriptional regulator; similar to psr protein: residues 1-462 are 56% similar to the protein in S.pyogenes gi15675283)and are 47% similar to the protein from S.pneumoniae (gi15901222).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0632 (1e-141).","

InterPro
IPR004474
Domain

Cell envelope-related transcriptional attenuator
PF03816	$\"[205-381]T$	LytR_cpsA_psr
TIGR00350	$\"[204-381]T$	lytR_cpsA_psr

","BeTs to 5 clades of COG1316COG name: Transcriptional regulators, LytR familyFunctional Class: KThe phylogenetic pattern of COG1316 is ------vC-BR-----ol---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 16-212 are 32% similar to a (PROTEOME TRANSCRIPTION COMPLETE REGULATOR) protein domain (PD400055) which is seen in Q9CEY2_LACLA.Residues 295-361 are 46% similar to a (PROTEOME TRANSCRIPTION COMPLETE REGULATOR) protein domain (PD392203) which is seen in Q9CEY2_LACLA.Residues 96-222 are 36% similar to a (PSR) protein domain (PD307291) which is seen in Q9K2N9_ENTFA.Residues 362-416 are 50% similar to a (PSR PBP5 TRANSCRIPTION COMPLETE) protein domain (PD084057) which is seen in Q9CEY2_LACLA.Residues 213-294 are 53% similar to a (PROTEOME COMPLETE REGULATOR) protein domain (PD355667) which is seen in Q9CEY2_LACLA.Residues 223-361 are 45% similar to a (COMPLETE PROTEOME PSR REGULATORY) protein domain (PD003150) which is seen in Q9K2N9_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 14:23:30 2002","Fri Sep 8 11:23:07 2006","Fri Sep 8 11:22:25 2006","Tue Dec 18 12:26:48 2001","","Tue Dec 18 12:26:48 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0714 is paralogously related (blast p-value < 1e-3) to SMu0371, a predicted transcription regulator.","Thu Jan 17 14:22:09 2002","","No significant hits to the NCBI PDB database.","SMU.787","","Residues 205 to 381 (E-value = 8.3e-78) place SMu0714 in the LytR_cpsA_psr family which is described as Cell envelope-related transcriptional attenuator domain (PF03816)","Tue Dec 18 12:26:48 2001","24379245","","","","","","1","","","SMU.787","303" "SMu0715","738555","739910","1356","ATGTTAAAAAAGAATGATATTGTAGAAGTTGAGATTAGTGATCTCAGTCATGATGGCGCAGGTATTGCCAAGGTTGATGGCTTGGTCTTTTTTGTGGACAATGCTCTGCCGACTGAGAAAATCCGCATGCGCGTGCTCAAGGTCAAAAAGAACATTGCTTTCGGAAAAGTTGAAAGCTATTTAGCTAAGTCAGCTTACCGCAGTGATAATCTGACTGTAGACTACTTACGGACAGGAATTGCTGATTTGGGACATTTGACTTACGGACAGCAGCTTAACTTCAAGCGCAAGCAGGTCATCAATAGTCTCTCTAAAATCGCAGGCATTTCAGACATTGAAGTTGCAGATACACTTGGTATGGACAATCCAACTGCCTATCGCAATAAGGCTCAGGTTCCTGTCCGCCGTGTCAATGGTCAGTTAGAAACAGGATTCTTCCGCAAAAATTCTCATGCTCTCATGCCTATTGAAGATTACTACATTCAAGATAAAGAGATTGATCGGCTGATTAACTTCACACGTGATTTGCTGCGCCGCTTTGATCTTAAACCTTATGACGAAAAGGAGCAGACTGGTCTTATTCGTAATCTTGTCGTCCGCCGCGGACATTATACAGGCCAAATAATGCTGGTTTTGGTGACGACACGGTCAAAAATATTTCGTATTGAGCAAATGATTGAAAAGATTATCTCTGAATTTCCAGCGGTCAAATCCATTATTCAAAACATCAATGATAGAAATACCAATGCTATCTTTGGTTCAGAATTTAGAACGCTTTATGGAGAAGATACCATTGAAGATACCATGCTAGGCAACCGCTATATCATTTCCGCCCAATCTTTTTACCAAGTCAATACCGTCATGGCTGAGAAACTTTATCAGACAGCTATTGATTTTTCAGATCTGACACCAGATGATACCGTCATTGACGCTTACTCAGGAATTGGAACTATTGGCCTGTCCTTTGCTAAAAAAGTCAAGGATGTTTACGGAGTGGAAGTCATTGAAGCTGCGGTGCGTGACGCTGAGAAAAATGCTGCGCTCAATAATATCACAAACGTCCACTATGTGGCAGACTCAGCAGAGAAGGCCATGGCCAGCTGGAGTAAGCGAGGCATCAAACCAGACGTTATTCTGGTTGACCCACCACGAAAAGGCTTGACAGAAAGTTTCATCGAAGCAAGCACTGCTATGCAGCCCCGCAAAATCACCTACATCTCCTGCGCCCCCGCCACCATGGCGCGTGATGTCAAACTTTATGAAGAACTAGGGTACAAACTTGTCAAAGTCCAGCCGGTGGATTTGTTTCCGCAAACGCATCATGTGGAGTGCGTAGCTTTGCTCGTGAAAGCTTAG","8.60","3.62","50827","MLKKNDIVEVEISDLSHDGAGIAKVDGLVFFVDNALPTEKIRMRVLKVKKNIAFGKVESYLAKSAYRSDNLTVDYLRTGIADLGHLTYGQQLNFKRKQVINSLSKIAGISDIEVADTLGMDNPTAYRNKAQVPVRRVNGQLETGFFRKNSHALMPIEDYYIQDKEIDRLINFTRDLLRRFDLKPYDEKEQTGLIRNLVVRRGHYTGQIMLVLVTTRSKIFRIEQMIEKIISEFPAVKSIIQNINDRNTNAIFGSEFRTLYGEDTIEDTMLGNRYIISAQSFYQVNTVMAEKLYQTAIDFSDLTPDDTVIDAYSGIGTIGLSFAKKVKDVYGVEVIEAAVRDAEKNAALNNITNVHYVADSAEKAMASWSKRGIKPDVILVDPPRKGLTESFIEASTAMQPRKITYISCAPATMARDVKLYEELGYKLVKVQPVDLFPQTHHVECVALLVKA","739909","","RNA methyltransferase, TrmA family","Cytoplasm","Matches in gapped BLAST to RNA methyltransferase: residues 1-450 are 77% similar to the enzyme in S.pyogenes (gi15675282) and are 71% similar to the protein from S.pneumoniae (gi15900900).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0633 (0.0).","

InterPro
IPR001566
Family

23S rRNA methyltransferase/RumA
TIGR00479	$\"[15-443]T$	rumA

InterPro
IPR002792
Domain

Deoxyribonuclease/rho motif-related TRAM
PF01938	$\"[1-59]T$	TRAM
PS50926	$\"[1-59]T$	TRAM

InterPro
IPR010280
Family

(Uracil-5)-methyltransferase
PF05958	$\"[87-451]T$	tRNA_U5-meth_tr
PS01230	$\"[381-412]N$	TRMA_1
PS01231	$\"[433-443]T$	TRMA_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[276-438]T$	G3DSA:3.40.50.150
PTHR11061	$\"[10-450]T$	PTHR11061
PTHR11061:SF2	$\"[10-450]T$	PTHR11061:SF2
SSF50249	$\"[6-65]T$	Nucleic_acid_OB
SSF53335	$\"[66-450]T$	SSF53335

","BeTs to 9 clades of COG2265COG name: SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferaseFunctional Class: JThe phylogenetic pattern of COG2265 is ------vC-BR-----ol---Number of proteins in this genome belonging to this COG is 2","***** IPB001566 (RNA methyltransferase trmA family) with a combined E-value of 1.4e-40. IPB001566A 308-349 IPB001566B 378-388 IPB001566C 403-412 IPB001566D 425-448","Residues 85-300 are 48% similar to a (METHYLTRANSFERASE PROTEOME RNA COMPLETE 2.1.1.-) protein domain (PD007501) which is seen in Q9CGB9_LACLA.Residues 400-446 are 72% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME RNA TRNA) protein domain (PD004091) which is seen in Q9CGB9_LACLA.Residues 300-356 are 52% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME ARGININE) protein domain (PD006760) which is seen in O31503_BACSU.Residues 181-362 are 27% similar to a (METHYLTRANSFERASE TRNA) protein domain (PD035416) which is seen in Y118_CHLMU.Residues 3-58 are 58% similar to a (PROTEOME COMPLETE METHYLTRANSFERASE RNA) protein domain (PD007943) which is seen in Q9CGB9_LACLA.Residues 302-363 are 59% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD030986) which is seen in Q9CGB9_LACLA.Residues 124-296 are 24% similar to a (PROTEOME METHYLTRANSFERASE COMPLETE) protein domain (PD338157) which is seen in Q9KL20_VIBCH.Residues 306-356 are 50% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE TRNA) protein domain (PD292646) which is seen in Q9KEF5_BACHD.Residues 300-357 are 43% similar to a (PROTEOME YFJO COMPLETE) protein domain (PD386579) which is seen in O31545_BACSU.Residues 273-387 are 30% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE RNA) protein domain (PD099587) which is seen in O66617_AQUAE.Residues 200-297 are 23% similar to a (PROTEOME COMPLETE Y FF) protein domain (PD396785) which is seen in Q9CDP0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:49:59 2002","Thu Jul 27 11:11:17 2006","Thu Jul 27 11:11:17 2006","Tue Dec 18 14:19:31 2001","Tue Dec 18 14:19:31 2001","Tue Dec 18 14:19:31 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0715 is paralogously related (blast p-value < 1e-3) to SMu1619, also a predicted RNA methyltransferase.","Sat Jan 5 09:04:25 2002","","No significant hits to the NCBI PDB database.","SMU.788","","Residues 1 to 59 (E-value = 4.4e-08) place SMu0715 in the TRAM family which is described as TRAM domain (PF01938)Residues 87 to 451 (E-value = 4e-07) place SMu0715 in the tRNA_U5-meth_tr family which is described as tRNA (Uracil-5-)-methyltransferase (PF05958)","Thu Jul 27 11:11:17 2006","24379246","","","Thanedar S, Dineshkumar TK, Varshney U.The Mere Lack of rT Modification in Initiator tRNA Does Not Facilitate Formylation-Independent Initiation inEscherichia coli.J Bacteriol. 2001 Dec;183(24):7397-402.PMID: 11717300Frees D, Varmanen P, Ingmer H.Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation ofnon-native proteins andconcomitantly increases stress tolerance in Lactococcus lactis.Mol Microbiol. 2001 Jul;41(1):93-103.PMID: 11454203 ","","Thu Jul 27 11:11:17 2006","1","","","SMU.788","71" "SMu0716","740430","741065","636","ATGGATTTACTTGTTTCAAAATTGATGGTGAGCGGTGCGAATCTTGTCCTTTTTATTACTATTCCGTTTATCACTTGGATGGTAATTGGCAGGAAAACGGCTTCTTTCTTTAATTGGCTCGGCTTAAAAAAGATTCAACATAAACTAAATAGCAGTGATTTGTTAATCATCTTAGGTGTTTTAGCCGTGACTTTATTAGTGGGGCCTTTTGGTTTCAATTTACTGAAAAATATCAATGGTTTAATGCCTGAGGGAGCTTCAATGGGAATGTTTGAATTTTCAGGACGAGGTGTGAGTGCTCTTCCTGCTATATTGGTACAATCCCTCTTTAATACGTCTCTTCTCGAAGAAGTGTTCTTTAGGGGCTTCTTGTTAAAGCGTTTTTCAAACCGCTTGGGATTTGCATTAAGAAATACAACGCAAGCACTGCTCTTTGGACTCATGCATAGCATCTTTCTTTTCTTGGCTGGTAAAGTAATATTGGCAATTATAATCACTCTTTTTACAGGTCTTTTTGGATGGCTTTCAGGATATATTACTGAAAAGAAGTTTGCTGGTTCAATATTGCCAAGCTGGTGCATTCATGGAGTAGGAAATGTTATTTCTAACTCGTTAATAGCATTTTCTTTGCTTTAA","11.00","9.66","23136","MDLLVSKLMVSGANLVLFITIPFITWMVIGRKTASFFNWLGLKKIQHKLNSSDLLIILGVLAVTLLVGPFGFNLLKNINGLMPEGASMGMFEFSGRGVSALPAILVQSLFNTSLLEEVFFRGFLLKRFSNRLGFALRNTTQALLFGLMHSIFLFLAGKVILAIIITLFTGLFGWLSGYITEKKFAGSILPSWCIHGVGNVISNSLIAFSLL","741064","","conserved hypothetical protein (similar to BlpY)","Membrane, Cytoplasm","Matches weakly in gapped BLAST to BlpY and hypothetical proteins: residues 57-202 are 29% similar to BlpY protein in S.pneumoniae (gi|15902516|) and residues 92-202 are 25% similar to hypothetical protein in Deinococcus radiodurans (gi|15805883|). SMu0716 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003675
Family

Abortive infection protein
PF02517	$\"[102-206]T$	Abi

","BeTs to 5 clades of COG1266COG name: Predicted membrane proteinFunctional Class: SThe phylogenetic pattern of COG1266 is --T--qvC-BR-----o-in-Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 08:27:19 2002","Sat Oct 12 10:50:44 2002","Sat Oct 12 10:50:44 2002","Tue Dec 18 14:24:12 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0716 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 14:24:29 2001","","No significant hits to the NCBI PDB database.","SMU.789","","Residues 102 to 206 (E-value = 9.5e-08) place SMu0716 in the Abi family which is described as CAAX amino terminal protease family (PF02517)","Tue Dec 18 14:24:12 2001","24379247","","","","","","1","","","SMU.789","" "SMu0717","741646","741885","240","ATGAGAAAACAAACGCTTGGTATGATAATTTCATCATTGAGAAAAGAAAAAGGAATGACACAATTAGAACTAGCTGAAAAAATGCGGGTAACAGATAAAGCCGTTTCTAAATGGGAAAGAGATTTATCTTTTCCAGATATTAATTCTATTCCCAAATTAGCAGAAATATTTGAAGTGTCAGTAGATGATTTAATGCAAGTTAAGACAAATACAAAAGAAACTATTGGTAAGAATAAATAA","10.10","2.99","9053","MRKQTLGMIISSLRKEKGMTQLELAEKMRVTDKAVSKWERDLSFPDINSIPKLAEIFEVSVDDLMQVKTNTKETIGKNK","741884","","conserved hypothetical protein","Cytoplasm, Periplasm","Matches in gapped BLAST to hypothetical protein:residues 14-74 are25% similar to the previously published unknown protein in S.mutans (gi|1196926|).Residues 6-66 are 40% similar to the protein in S.pyogenes (gi|15675661|) and are 40% similar to the protein in S.aureus (gi|14141827|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1716 (3e-11).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[10-64]T$	HTH_3
SM00530	$\"[9-64]T$	HTH_XRE
PS50943	$\"[10-64]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[1-76]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[1-76]T$	G3DSA:1.10.260.40

","BeTs to 6 clades of COG1396COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1396 is --T--qV-EBR---------xNumber of proteins in this genome belonging to this COG is 6","No significant hits to the Blocks database.","Residues 13-64 are 44% similar to a (COMPLETE PROTEOME REGULATOR) protein domain (PD000418) which is seen in Q46240_CLOPE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 17 11:21:28 2002","Tue Dec 18 15:13:51 2001","Wed Mar 20 08:28:25 2002","Tue Dec 18 15:13:51 2001","","Tue Dec 18 15:13:51 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0717 is paralogously related (blast p-value < 1e-3) to SMu0737,a predicted hypothetical protein; possible transcriptional regulator, SMu0366, and SMu0197,both predicted conserved hypothetical proteins / possible transcriptional regulators.","Thu Jan 17 11:19:15 2002","","No significant hits to the NCBI PDB database.","SMU.790","","Residues 10 to 64 (E-value = 3.9e-14) place SMu0717 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Tue Dec 18 15:13:51 2001","24379248","","","","","","1","","","SMU.790","" "SMu0718","742105","741866","240","ATGATTTTTCACTTTAAAATTAAAATTATGACTCCAGTCAACAAAAATACTTATTTTTCTTCCTTTTTGCCTTTTAACAAAATAACAGATACACTTGCTGCTCCAATACCAAGCATCATCAATGCAGACTTTATATCTAATCTTCCCAAAACGGATAAAACCACTACTGCAATCCCCATAGCTGTTCCAATTCCTTTCAGCGCAGTATCAATAATTTCAGTTATTTATTCTTACCAATAG","10.30","3.21","8762","MIFHFKIKIMTPVNKNTYFSSFLPFNKITDTLAAPIPSIINADFISNLPKTDKTTTAIPIAVPIPFSAVSIISVIYSYQ","741871","","hypothetical protein","Periplasm, Extracellular","No significant hits in gapped BLAST found.SMu0718 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[57-77]?$	transmembrane_regions

InterPro
IPR003736
Domain

Phenylacetic acid degradation-related protein
TIGR00369	$\"[8-122]T$	unchar_dom_1

InterPro
IPR006683
Domain

Thioesterase superfamily
PF03061	$\"[39-114]T$	4HBT

noIPR
unintegrated

unintegrated
G3DSA:3.10.129.10	$\"[5-123]T$	G3DSA:3.10.129.10
PTHR21660	$\"[3-124]T$	PTHR21660
SSF54637	$\"[14-127]T$	SSF54637

","BeTs to 4 clades of COG2050COG name: Uncharacterized protein PaaI, possibly involved in aromatic compounds catabolismFunctional Class: RThe phylogenetic pattern of COG2050 is A--k-q--Ebrhuj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 16-114 are 34% similar to a (COMPLETE PROTEOME PAAI PHENYLACETIC) protein domain (PD006741) which is seen in PAAI_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 08:30:02 2002","Tue Dec 18 15:18:32 2001","Wed Mar 20 08:30:02 2002","Tue Dec 18 15:18:32 2001","","Tue Dec 18 15:18:32 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0719 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 11:15:22 2002","","No significant hits to the NCBI PDB database.","SMU.793","","Residues 39 to 115 (E-value = 3.7e-18) place SMu0719 in the 4HBT family which is described as Thioesterase superfamily (PF03061)","Tue Dec 18 15:18:32 2001","24379250","","","","","","1","","","SMU.793","815" "SMu0720","742803","743180","378","ATGTCTTTGTTTAGTTGGTTTAAAAAAACGCAGGCTCCTCAAAATTTCGAATCTGGCTTATCTTTGACAAGTCAAAAGGGTGACCTCTTAAACCCTAATTCAAAAGAAGTTGAGGAAGCTATTGTCTCACTCAGTAATGATCCAGAAGGTTTTGTCACCTTGTCTTGGACCAGTGTCAGTGGAGATTTTTCCTTTATTCAGGCACTTTGCTTTGATGGTTCTTACCTTATTGAATATCGAACGGCTGATTTAAAAAAGGGCTATGTCTATAGAAAGCCCAATGTCCCAATAGAAGAAACGTTACAATTCTTTCGGTCATTTTTGGAAAATCAGACACTGACTCTTGATGCTGATTGGCTACAAGTCAAAGCATATTAA","4.50","-5.05","14251","MSLFSWFKKTQAPQNFESGLSLTSQKGDLLNPNSKEVEEAIVSLSNDPEGFVTLSWTSVSGDFSFIQALCFDGSYLIEYRTADLKKGYVYRKPNVPIEETLQFFRSFLENQTLTLDADWLQVKAY","743179","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu0720 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 11:15:49 2002","Tue Dec 18 15:40:59 2001","Thu Jan 24 11:15:49 2002","Tue Dec 18 15:40:59 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0720 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 11:15:49 2002","","No significant hits to the NCBI PDB database.","SMU.794","","No significant hits to the Pfam 11.0 database","Tue Dec 18 15:40:59 2001","24379251","","","","","","1","","","SMU.794","" "SMu0721","743214","743621","408","ATGACAGCATATCACCATTTGGTTCAATATTATGAAACTGATCGTATGGGGATTACCCATCATTCTAATTATATTCGTTGGATGGAAGAAGCCCGTGTTCATTTCTTGGCAGAAATTGGTTGGCCTTACGATAAATTAGAGGAAGCAGGCATTATTTCACCAGTAACTGCAGTTCATTGTATTTACTTAGCAACTTCAACCTTTGCTGATACAATTAGCATTAGCGTAGAAGTAGAAAAGGTCAAAGCTGCCCGACTTACTCTTAGTTATCAAATGATTAATCAAAAAGGGAAAACTGTCTGTCAAGCACAATCGGAACATAGCTTTTTGACTCTAGAAAATCGCTTTGTTAATCTGAAAAAGAATTTTCCAGATTTCTATGATAAATTAGCAGCATTAAGTCAGTAA","6.90","-0.42","15589","MTAYHHLVQYYETDRMGITHHSNYIRWMEEARVHFLAEIGWPYDKLEEAGIISPVTAVHCIYLATSTFADTISISVEVEKVKAARLTLSYQMINQKGKTVCQAQSEHSFLTLENRFVNLKKNFPDFYDKLAALSQ","743620","","conserved hypothetical protein (possible esterase)","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein,possible esterase: residues 8-128 are 32% similar to the protein in B.halodurans (gi|15614851|).Residues 8-130 are 28% similar to esterase in Clostridium acetobutylicum (gi|15893563|).SMu0721 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006683
Domain

Thioesterase superfamily
PF03061	$\"[16-101]T$	4HBT

noIPR
unintegrated

unintegrated
G3DSA:3.10.129.10	$\"[4-126]T$	G3DSA:3.10.129.10
SSF54637	$\"[1-127]T$	SSF54637

","BeTs to 6 clades of COG0824COG name: Predicted esteraseFunctional Class: RThe phylogenetic pattern of COG0824 is --t--q-CEBRhuj---l---Number of proteins in this genome belonging to this COG is 1","***** IPB000365 (4-hydroxybenzoyl-CoA thioesterase family active site) with a combined E-value of 4.2e-12. IPB000365 7-36","Residues 16-128 are 30% similar to a (PROTEOME COMPLETE HYDROLASE VC1840) protein domain (PD401074) which is seen in Q9KAJ9_BACHD.Residues 8-82 are 36% similar to a (COMPLETE PROTEOME HYDROLASE THIOESTERASE) protein domain (PD007339) which is seen in Q9KBC9_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:51:55 2002","Sat Oct 12 10:51:55 2002","Sat Oct 12 10:51:55 2002","Tue Dec 18 15:45:40 2001","Tue Dec 18 15:45:40 2001","Tue Dec 18 15:45:40 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0721 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Dec 18 15:49:48 2001","","No significant hits to the NCBI PDB database.","SMU.795","","Residues 16 to 102 (E-value = 2.5e-08) place SMu0721 in the 4HBT family which is described as Thioesterase superfamily (PF03061)","Tue Dec 18 15:45:40 2001","24379252","","","","","","1","","","SMU.795","" "SMu0722","743711","744544","834","ATGATAGGAATCACAGGCGTAACAGGGAAATTAGGTAGTAAAGTTGCTCAATTAATTTCAGAACAAGGCATCTCAGCGAGACATTTGGCTAGAAACCCTCAAAGAGCAGCTTTATATGATAATGCTGAACTTGTGCAGGTTGCTTTTGAAAATTCTCTAGAGGCTGTTGAAGCTTTAAAAGGTATTGATGTTTTACTAATGGTATCCGCATCAGAAAGTCCCAATCGTTTGCAGCAGCATTTTGCTTTTCTTGATGCAGCTCATGAAGCGGGTGTTAAGCATATTGTTTACACATCCTTTTATAATGCTGCTACTGAAGCTACTTTTACTTTAGCGCGTGATCATGCTAAGACAGAAAAATATATCAAGGAAAGAGGTTTTACTTACACCTTCTTGCGTGATAATTTTTATCTGGATTTCTTCTTAGATTTGTGTTTGAACAATGGTGAGATCCGCGGTCCAGCTGGTAATGGTAAAGTTTCTGCTGTAGCTCGTCAGGACGTCTCTGAAGTGGCGACAACTATTCTAGCTAAGCCTGACAAATGGAAAAATCAGCTATTGAACATGACTGGTCCGGCAGATTTGTCAATGGCTGATATTGTTCATTTTGTCAGTGAGCAAAAGGGTGAAATCATTCCTTATATTGATGAGAGCATTGAAGAAGCTTATGCATCTCGTAAAGCTTGGCCAGCACAAGACTGGGAATATGATGCTTGGGTTAGTACTTATACAGCTATTAAAGAAGGAAAGCAAGCTGGGGTTTCTTCAGATATTGAACGTGTTCTCGGACGTCCAGCAACTTCTTTGGAACAATTAGTTAAAACAATAAAATAA","5.50","-5.59","30605","MIGITGVTGKLGSKVAQLISEQGISARHLARNPQRAALYDNAELVQVAFENSLEAVEALKGIDVLLMVSASESPNRLQQHFAFLDAAHEAGVKHIVYTSFYNAATEATFTLARDHAKTEKYIKERGFTYTFLRDNFYLDFFLDLCLNNGEIRGPAGNGKVSAVARQDVSEVATTILAKPDKWKNQLLNMTGPADLSMADIVHFVSEQKGEIIPYIDESIEEAYASRKAWPAQDWEYDAWVSTYTAIKEGKQAGVSSDIERVLGRPATSLEQLVKTIK","744543","","conserved hypothetical protein (possible oxidoreductase)","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein and oxidoreductases: residues 2-273 are 32% similar to the protein in Deinococcus radiodurans (gi|15805052|).Residues 1-273 are 27% similar to oxidoreductase in E.coli (gi|15804802|)SMu0722 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR008030
Family

NmrA-like
PF05368	$\"[2-216]T$	NmrA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[2-214]T$	G3DSA:3.40.50.720
PTHR14194	$\"[30-277]T$	PTHR14194
PTHR14194:SF2	$\"[30-277]T$	PTHR14194:SF2
SSF51735	$\"[2-235]T$	SSF51735

","BeTs to 3 clades of COG0702COG name: Predicted nucleoside-diphosphate-sugar epimerasesFunctional Class: M,GThe phylogenetic pattern of COG0702 is ----Yq-CEB-----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 2-129 are 38% similar to a (REDUCTASE PROTEOME COMPLETE ISOFLAVONE) protein domain (PD334334) which is seen in Q9RYD9_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 08:32:16 2002","Sat Oct 12 10:52:31 2002","Sat Oct 12 10:52:31 2002","Tue Dec 18 15:52:39 2001","","Tue Dec 18 15:52:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0722 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 11:16:37 2002","","No significant hits to the NCBI PDB database.","SMU.796","","No significant hits to the Pfam 11.0 database","Tue Dec 18 15:52:39 2001","24379253","","","","","","1","","","SMU.796","" "SMu0723","744579","744797","219","ATGATGATTGTATTAACTTATTTAGATGCTTATCAAACAAAAAAGAAAGCTTCGTTTAACAGTATTGAAGAATTCATGCTTTCACTGAGTGGCTGTGTCACTTTACCAGATTCTTATCAAGTTTTGTCCTTAACTTATAAAGGAAAAGATATTGGCTACCGCGGTTTATTTGGTGATTTATACCGTAAGGTTTATCAAATGGATTGGTCTTCAGTTTGA","8.40","0.93","8292","MMIVLTYLDAYQTKKKASFNSIEEFMLSLSGCVTLPDSYQVLSLTYKGKDIGYRGLFGDLYRKVYQMDWSSV","744796","","conserved hypothetical protein","Extracellular","Limited matches in gapped BLAST to hypothetical proteins: residues 2-69 are 48% similar to the protein in S.pneumoniae gi|15900960| and gi|15903043|.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1322 (4e-16).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 08:35:22 2002","Tue Dec 18 15:55:01 2001","Wed Mar 20 08:35:22 2002","Tue Dec 18 15:55:01 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0723 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 11:17:02 2002","","No significant hits to the NCBI PDB database.","SMU.797","","No significant hits to the Pfam 11.0 database","Tue Dec 18 15:55:01 2001","24379254","","","","","","1","","","SMU.797","1031" "SMu0724","745061","744933","129","ATGTTTATCTTTTTGCAGCCGTCCGTAGCTCGTATTCAATTAGAATTTGATCCTAAAGTCTCAAATCTTCCAAGTAGCAGAAACATCAACGTTTCTGCTACTTTTATCACGGAGAAAAGTCTCGTTTAG","9.50","0.98","4721","MFIFLQPSVARIQLEFDPKVSNLPSSRNINVSATFITEKSLV","744938","","hypothetical protein","Extracellular, Periplasm","No hits in gapped BLAST found.SMu0724 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 11:17:31 2002","Tue Dec 18 15:55:52 2001","Thu Jan 24 11:17:31 2002","Tue Dec 18 15:55:52 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0724 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 11:17:31 2002","","No significant hits to the NCBI PDB database.","SMU.798c","","No significant hits to the Pfam 11.0 database","Tue Dec 18 15:55:52 2001","24379255","","","","","","1","","","SMU.798c","" "SMu0725","745623","745261","363","ATGTCAATTTACAGCAAATCTTATGTCACCACTCCCCAACACTCAGCTATGAATTGGGGTTCAGGCAGTCTTAATGTTTTATCAACTCCCAGTATGATTGCTTTTATAGAAAATGCAGCTTTTCTGTACTGTGAAGAAGATTTAGATGTGTCAAAAACAACTGTCGGTGCTCAAATTACTGTCCAGCATTTGGCCGCTACTAAAATTGGTCAAACAGTAGAAGTCAAAATTTTAGCTGTTGAAAAAGATGGACATCACACCCATTTCCAAATAGAAGTTTACGAAGGAGATAAACTTATCGGTAAGGGTGAACACACACGCGTCACTATCAACATCAAAAGATTCCTTGATAAATTAGAATAA","6.50","-1.61","13306","MSIYSKSYVTTPQHSAMNWGSGSLNVLSTPSMIAFIENAAFLYCEEDLDVSKTTVGAQITVQHLAATKIGQTVEVKILAVEKDGHHTHFQIEVYEGDKLIGKGEHTRVTINIKRFLDKLE","745266","","conserved hypothetical protein","Cytoplasm, Membrane","Matches in gapped BLAST to hypothetical protein: residues 1-119 are 49% similar to the protein in S.pyogenes (gi|15675277|). Residues 6-119 are 42% similar to the protein in Sulfolobus tokodaii (gi|15920895|). SMu0725 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF54637	$\"[22-111]T$	SSF54637

noIPR
unintegrated

unintegrated
signalp	$\"[1-70]?$	signal-peptide
tmhmm	$\"[57-79]?$	transmembrane_regions

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[161-287]T$	MMR_HSR1

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[158-335]T$	small_GTP

InterPro
IPR006073
Domain

GTP1/OBG
PR00326	$\"[163-183]T$ $\"[184-202]T$ $\"[212-227]T$ $\"[229-247]T$	GTP1OBG

InterPro
IPR006074
Domain

GTP1/OBG domain
PS00905	$\"[214-227]T$	GTP1_OBG

InterPro
IPR006169
Domain

GTP1/OBG subdomain
PF01018	$\"[4-159]T$	GTP1_OBG

InterPro
IPR014100
Family

GTP-binding protein Obg/CgtA
TIGR02729	$\"[4-290]T$	Obg_CgtA

InterPro
IPR015349
Domain

GTP1/OBG, C-terminal
PF09269	$\"[366-434]T$	DUF1967

noIPR
unintegrated

unintegrated
G3DSA:2.70.210.12	$\"[3-159]T$	G3DSA:2.70.210.12
G3DSA:3.40.50.300	$\"[159-399]T$	G3DSA:3.40.50.300
PTHR11702	$\"[3-357]T$	PTHR11702
PTHR11702:SF3	$\"[3-357]T$	PTHR11702:SF3
SSF102741	$\"[363-436]T$	SSF102741
SSF52540	$\"[151-363]T$	SSF52540
SSF82051	$\"[3-159]T$	SSF82051

","BeTs to 13 clades of COG0536COG name: Predicted GTPaseFunctional Class: RThe phylogenetic pattern of COG0536 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000765 (GTP1/OBG family) with a combined E-value of 1.9e-20. IPB000765 161-204","Residues 236-325 are 71% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in Q9KDK0_BACHD.Residues 14-159 are 66% similar to a (GTP-BINDING COMPLETE PROTEOME OBG) protein domain (PD004315) which is seen in Q9CF94_LACLA.Residues 343-436 are 54% similar to a (GTP-BINDING OBG PROTEOME SPORULATION) protein domain (PD015821) which is seen in Q9CF94_LACLA.Residues 222-274 are 77% similar to a (GTP-BINDING PROTEOME COMPLETE OBG) protein domain (PD046517) which is seen in Q9CF94_LACLA.Residues 222-325 are 35% similar to a (F24B9.32 M01E5.2 F22G5.1) protein domain (PD407462) which is seen in Q9LNY4_ARATH.Residues 275-325 are 60% similar to a (PROTEOME GTP-BINDING COMPLETE OBG) protein domain (PD385107) which is seen in Q9CF94_LACLA.Residues 221-287 are 34% similar to a (C26E6 COSMID) protein domain (PD415761) which is seen in Q18220_CAEEL.Residues 212-277 are 40% similar to a (GTP-BINDING COMPLETE PROTEOME HOMOLOG) protein domain (PD186802) which is seen in Q9HP92_HALN1.Residues 221-274 are 40% similar to a (GTP-BINDING PROTEOME COMPLETE OBG) protein domain (PD383651) which is seen in YHBZ_HAEIN.Residues 221-287 are 35% similar to a (GTP-BINDING CDC23-DBP8) protein domain (PD414677) which is seen in Q9UT06_SCHPO.Residues 221-311 are 36% similar to a (PROTEOME ION GTP-BINDING ATP-BINDING) protein domain (PD397185) which is seen in Q9PJ30_CAMJE.Residues 157-220 are 76% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9KDK0_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:53:40 2002","Thu Aug 10 11:03:11 2006","Thu Aug 10 11:03:11 2006","Tue Dec 18 16:01:37 2001","Tue Dec 18 16:01:37 2001","Tue Dec 18 16:01:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0727 is paralogously related (blast p-value < 1e-3) to SMu0004, SMu1343, and SMu1471, all GTP-binding proteins.","Thu Jan 24 11:20:03 2002","","No significant hits to the NCBI PDB database.","SMU.801","","Residues 17 to 289 (E-value = 9.1e-120) place SMu0727 in the GTP1_OBG family which is described as GTP1/OBG family (PF01018)","Tue Dec 18 16:01:37 2001","161486823","","","Okamoto,S., Itoh,M. and Ochi,K.Molecular cloning and characterization of the obg gene ofStreptomyces griseus in relation to the onset of morphologicaldifferentiationJ. Bacteriol. 179 (1), 170-179 (1997)PubMed: 8981995","","Tue Dec 18 16:06:29 2001","1","","","SMU.801","156" "SMu0728","747742","747924","183","ATGGGAGATAAACCCATATCTTTTAAAGATAAAGATGGTAATTTTGTTTCGGCTGCCGATGTTTGGAATGCTGAAAAATTGGAGAAACTTTTCAATAAGCTCAATCCTAATCGCAAATTACGCTTGGAACGAGAAAAATTGGCTAAGGAGAAAGACGAAGTTAAACCATCTGAAATGACTTAG","9.80","1.99","6961","MGDKPISFKDKDGNFVSAADVWNAEKLEKLFNKLNPNRKLRLEREKLAKEKDEVKPSEMT","747923","","conserved hypothetical protein","Extracellular, Periplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 1-51 are 88% similar to the protein in S.pyogenes gi|15675272| and residues 1-46 are 80% similar to the protein in S.pneumoniae gi|14972555|The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1469 (4e-24).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-55 are 45% similar to a (PROTEOME COMPLETE) protein domain (PD383538) which is seen in Q9CF95_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 08:39:00 2002","Tue Dec 18 16:09:50 2001","Wed Mar 20 08:39:00 2002","Tue Dec 18 16:09:50 2001","","Tue Dec 18 16:09:50 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0728 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 11:20:33 2002","","No significant hits to the NCBI PDB database.","SMU.802","","No significant hits to the Pfam 11.0 database","Tue Dec 18 16:09:50 2001","24379259","","","","","","1","","","SMU.802","952" "SMu0729","749466","747961","1506","ATGTTACAGATTCAAAATCTTACCATTACGCACCAAAAAGATCTACAAATACTCGTTAAAGATTTGTCCTTAGTCGTCAATCCTGGTGAGAAATTAGCTATTATCGGGGAGGAAGGGACCGGTAAGTCTACTCTCCTCAAGACTATACTCAGCCCTGAGCTGATTGGCAACTACGCTGATGTGACAGGTACTATTCAGAATAGTTTTAACCGAATCGGTTACTTGCCACAAAACATGGAAGATAAAGATTTAACTCTAACCATTAAAAACTATATTTACCATGATATAGATTTTGACCATTTTGATTTTAATCTTTTTTATCAAATGGCAGAGCGTTTTCAGTTTGACAGTCAGCGATTTGACGACGATGTCCAGAGCATTTCTAGTCTTTCTGGCGGAGAGAAATTAAAACTGCAGCTGCTGAAAATGCTTGCCTACAATCCTGACTTACTTCTTTTTGATGAGCCTTCTAGTGACTTGGATCTGGACACAATGACTTGGCTGGAGTATTTTATCAGCCAGACAAACAAAACCATTATTTTCATTTCTCATGATGAAGCACTACTTAGGAAATGTGCTACTGCTATCCTTCATTTGGAATTGCTCAAGAAACGCCAAAACCCCCGCGCCAGCTATTTCCAAGGAAACTATAAGAACTACAAAAGTTGGCGAAAGAATAGCTTTAATAAGCAGCTTCAAGTCGCGCAAAAAGAACGTGAGGAACATACCAAAAAAATGGAACGCCACCACCGCATTCATCAGAGTGTGGAACATCAACTGCGCAACACCAAAAATGATGTTGCAGGTCGGCTGCTGGCCAAGAAAATGAAAAATGTCCTGTCTCAGGGAAAACGCTATGCCAAGGAGGCCAAAAACTTCACGGAAATTCCGCAGGATATGGATGCTATTAACCTCTTTTTCACGAAAGTTAAATCTTTGCCTGCCAACAAAGTTCTACTGCATTGGGAAAATCGTCCTTTGCCGACAGGACAAGTAATTAATTTTGACATTCGCGGTCAGGATAAGCTGGTTATCACAGGACAAAATGGAATTGGCAAGACGCGCCTGCTTAAAGAGGTTCTTACCGAGTTAACCACAAAATCAGATCTATCTATCTGTTATATGCCACAAAACTACGAAGAGTTACTGGATGGTAAGCTGTCTGCTCTGCAATTTCTCAAAGAAAGTGCGGGCGAAGAATCTTGCCGTAATCTTCTAGCTAGTCTCCAATTCACACGGGATGAAATCACGCACTCTGTTGCAAGCTTATCGGGCGGTCAGAAGGCTAAACTCTTTTTAGCTCAAATGGTCTTGGAAAGCAGCAATGTCCTGCTGCTGGACGAGCCAACCCGCCACTTTTCACCAACTAGTCAGCCTCTTATTCGACAGCTTTTCAAGGATTTTCCGGGTTGTATTATCAGCGTATCGCACGATAGACAATTTATAGATGAAGTCGTTAATAAACACTACAAATTAAATCAAACAGAATTAGTGAATCTAGACTAA","7.70","3.46","57660","MLQIQNLTITHQKDLQILVKDLSLVVNPGEKLAIIGEEGTGKSTLLKTILSPELIGNYADVTGTIQNSFNRIGYLPQNMEDKDLTLTIKNYIYHDIDFDHFDFNLFYQMAERFQFDSQRFDDDVQSISSLSGGEKLKLQLLKMLAYNPDLLLFDEPSSDLDLDTMTWLEYFISQTNKTIIFISHDEALLRKCATAILHLELLKKRQNPRASYFQGNYKNYKSWRKNSFNKQLQVAQKEREEHTKKMERHHRIHQSVEHQLRNTKNDVAGRLLAKKMKNVLSQGKRYAKEAKNFTEIPQDMDAINLFFTKVKSLPANKVLLHWENRPLPTGQVINFDIRGQDKLVITGQNGIGKTRLLKEVLTELTTKSDLSICYMPQNYEELLDGKLSALQFLKESAGEESCRNLLASLQFTRDEITHSVASLSGGQKAKLFLAQMVLESSNVLLLDEPTRHFSPTSQPLIRQLFKDFPGCIISVSHDRQFIDEVVNKHYKLNQTELVNLD","747966","This sequence contains two nucleotide binding domains.","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several matches in gapped BLAST to ABC transporter, ATP-binding proteins: residues 1-501 are 41% similar to the protein in S.pneumoniae (gi|15901142|). Residues 1-488 are 25% and residues 29-272 are 26% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673044|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1340 (5e-38).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[130-172]T$ $\"[423-464]T$	ABC_transporter
PF00005	$\"[29-202]T$ $\"[339-495]T$	ABC_tran
PS00211	$\"[423-437]?$	ABC_TRANSPORTER_1
PS50893	$\"[2-226]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-203]T$ $\"[339-501]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-246]T$ $\"[277-498]T$	G3DSA:3.40.50.300
PTHR19211	$\"[96-258]T$ $\"[276-498]T$	PTHR19211
PTHR19211:SF11	$\"[96-258]T$ $\"[276-498]T$	PTHR19211:SF11
SSF52540	$\"[2-206]T$ $\"[320-498]T$	SSF52540

InterPro
IPR014966
Family

FRG domain
PF08867	$\"[37-141]T$	FRG

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[141-183]T$	ABC_transporter
PF00005	$\"[31-216]T$	ABC_tran
PS00211	$\"[141-155]T$	ABC_TRANSPORTER_1
PS50893	$\"[6-240]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-216]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[6-242]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-245]T$	PTHR19222
PTHR19222:SF33	$\"[6-245]T$	PTHR19222:SF33
SSF52540	$\"[6-243]T$	SSF52540

","BeTs to 8 clades of COG1126COG name: ABC-type polar amino acid transport system, ATPase componentFunctional Class: EThe phylogenetic pattern of COG1126 is a-----vcEB-Huj----inxNumber of proteins in this genome belonging to this COG is 7","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 8.1e-35. IPB001140A 20-66 IPB001140B 138-176 IPB001140C 192-221","Residues 186-224 are 89% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9CES4_LACLA.Residues 184-225 are 76% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174) which is seen in Q9JVC3_NEIMA.Residues 124-198 are 38% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in YN26_MYCTU.Residues 84-138 are 50% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9RUM8_DEIRA.Residues 5-243 are 26% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in O27709_METTH.Residues 125-218 are 32% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 74-115 are 54% similar to a (ATP-BINDING TRANSPORT PROTEOME ABC) protein domain (PD412673) which is seen in O34677_BACSU.Residues 184-240 are 59% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD255463) which is seen in GLNQ_ECOLI.Residues 141-220 are 37% similar to a (ATP-BINDING) protein domain (PD397028) which is seen in Q53712_STRAT.Residues 185-224 are 60% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9KGD1_BACHD.Residues 82-114 are 69% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496) which is seen in Q9CES4_LACLA.Residues 123-234 are 25% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 21-71 are 72% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CES4_LACLA.Residues 141-183 are 93% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CES4_LACLA.Residues 84-139 are 44% similar to a (ATP-BINDING PROTEOME AMINO COMPLETE) protein domain (PD194799) which is seen in Q9PKQ8_CHLMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:55:41 2002","Wed Dec 19 08:09:24 2001","Sat Oct 12 10:55:41 2002","Wed Dec 19 08:09:24 2001","Wed Dec 19 08:09:24 2001","Wed Dec 19 08:09:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0731 is paralogously related (blast p-value < 1e-3) to SMu0517, SMu0218, SMu1380, SMu0849, SMu0418, SMu1762, SMu1079, SMu1920, SMu1288, SMu1036, SMu1210, SMu1003, SMu0971, SMu0786, SMu1037, SMu0916, SMu0884, SMu1949, SMu1068, SMu1246, SMu1231, SMu1950, SMu0234, SMu1428, SMu0235, SMu1518, SMu0805, SMu0594, SMu1751, SMu1023, SMu1001, SMu1757, SMu0390, SMu1517, SMu0596, SMu0950, SMu0335, SMu0374, SMu0216, SMu0907, SMu1064, SMu1649, SMu0836, SMu0825, SMu0476, SMu1410, SMu0224, SMu0824, SMu1710, SMu0976, SMu1316, SMu0986, SMu0944, SMu0475, SMu0752, SMu1811, SMu0024, SMu0164, SMu0823, SMu0258, SMu1959, SMu1065, SMu0837, SMu1093, SMu0666, SMu1306, SMu0987, SMu0729, SMu1545, SMu1724, SMu1050, SMu1202, and SMu1686 all with ATP-binding capabilities.","Thu Jan 24 12:33:15 2002","Wed Dec 19 08:09:24 2001","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 263 2e-071pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 145 4e-036","SMU.805c","","Residues 31 to 216 (E-value = 1.1e-63) place SMu0731 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Dec 19 08:09:24 2001","24379262","","Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267, 4631-4637 (1992)PubMed: 1537846Russell RR, Ferretti JJNucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans.J Gen Microbiol 1990 May;136 ( Pt 5):803-10 PubMed: 2380687PMID: 2380687Aduse-Opoku J, Tao L, Ferretti JJ, Russell RRBiochemical and genetic analysis of Streptococcus mutans alpha-galactosidase.J Gen Microbiol 1991 Apr;137 ( Pt 4):757-64PubMed: 1649890 PMID: 1649890Ferretti JJ, Huang TT, Russell RRSequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.Infect Immun 1988 Jun;56(6):1585-8 PubMed: 2967248PMID: 2967248","","Tue Mar 26 09:47:44 2002","","1","","","SMU.805c","422" "SMu0732","754187","752001","2187","ATGAAGAACAAATTTAAAGCTCTGATGCTGGGAATCTTATCAGTAATCTTTATGTTTGGTGCCAAGGTATCCGCTGACACAGTTAAAATTGTATCAGATTCAACCTATGCTCCATTTGAATTTAAAGACAGTGATCAGGTCTATAAAGGAATTGATGTGGATATTATTAAAAAGGCCGCTGAAATGAGTGGTTGGAACTACAAAATGACTTTCCCGGGTTTTGATGCAGCTGTCAATGCCGTTCAATCAGGACAGGCAGATGCTCTTATGGCAGGGACAACTGTCACTAAGGAACGTGAAAAAGTCTTTACCTTTTCCCACACTTACTATGATACGAAAATCGTTATCGCTACTCGTAAACAAGACAAGATTACCAAATACAGTCAATTAAAAGGAAAAACGGTTGGGGTTAAGAATGGTACCGCTGCTCAAAGTTTTCTTGAAAAACATCAAGATAAATATGGTTACAAAATAAAATCCTTTGACACTGGCGATTCCATGTACAACAGCTTAGAGTCTGCCTCTGTAGATGCCGTTATGGATGATAAAGCTGTCGCTCAATACGCTATTAATCAAGGACAAAATCTTCGTATTGAAATGGATGGCGAGTCTATCGGAAGCTTTGCTTTTGCGGTTAAAAAAGGCAGCAAATACGAATATCTCATCAAAGATTTCAACAAAGCACTGAAAAAGATGAAGGCCGATGGCAGCTATGATGAAATCATGACGAAATGGATTTCTGCTAAATCTAAAACTGATGAGCAAAGCAAAACCAAAGAGACTGGTGATGCTAAAGCTAAGGCAAAACCTGTTAAAAGCAGCTATAAGGTTGTTATGGACTCTTCTTTTGCACCCTTTGAATTCCAAAACGATGCTGGCCAATACGTTGGTATTGATGTTGAATTAATCAAAGCTATTGCTAAGCAGCAAGGCTTCAAAATCAAAACTGAAAATCCTGGATTTGATGCTGCTCTCAATACTGTCCAATCCAGCCAAGCTGACGCCGTTATGGCAGGGATGTCTATTACCGATGATCGCAAGAAAATTTTTGATTTCTCTGATCCTTACTACACATCAAATACCTTACTAGCTGTCCGTAAAGGAAGCAATGTCGTATCCTACAAAGATTTGAAAGGCAAAAAAGTCGGCGCTAAAAACGGTACTGCTTCTTATACCTTCCTCGAAAAAAATAAGGCAAAATATGGTTACACACTGAAGTCGTTTGACGAAGCATCAACCATGTATGACAGTTTAAATTCAGGTTCTATCTATGCACTCATGGATGATGAAGCAGTTCTAAAATATGCTATCCAGCAAGGCCGCAAGTTTGAAACACCAATTCCTGGAGAAAAATCTGGTGAATATGGCTTTGCGGTTAAAAAAGGCAGCAGTCCTGAATTGATTCAAATGTTCAATAATGGTTTAGCAGCTCTGAAGAAATCCGGTCAGTACGATAAAATTATCAATAAATACCTTTCTGATAAGAAAAAGGATGCTAAATCAGAATCAAGTGTTGATGAGTCTACCATCTTTGGACTGCTTTCAAACAACTACAAGCAATTATTATCAGGGTTAGGAACGACTCTAAGCTTAGTGATTTTATCTTTTGCTCTGGCCATGATTGTTGGCATTCTCTTTGGTATGATGAGTGTCAGTCCTTATAAGACACTTCGAATCATCGCTTCTATCTTTGTTGATGTGGTTCGCGGTATCCCATTAATGATTGTTGCAGCCTTCATTTTCTGGGGTATTCCTAATCTCATTGAATCTATCACTGGTCATCAAAGCCCAATCAACGACTTTGTCGCTGGTACAATTGCCCTTACTTTAAATGGTGGTGCTTATATTGCCGAAATCGTTCGCGGCGGTATTGAAGCTGTTCCTAGCGGACAAATGGAAGCCAGCCGCAGTTTAGGGATTTCATATAAGACAACAATGAAACGAATTATCTTGCCGCAAGCTTTTAAATTAATGCTGCCTAACTTTATCAACCAATTTGTTATTTCATTGAAAGATACAACCATTATTTCAGCGATTGGACTGATTGAGCTCTTCCAAGCAGGAAAGATCATTATTGCACGTAATTACCAATCTTTCCGCATGTATGCTATCTTAGCCATCATGTATCTTGTGATTATCACGCTCTTAACCCGCCTAGCAAAACGTTTAGAAAAGAGGATTAAATAA","10.20","24.77","80240","MKNKFKALMLGILSVIFMFGAKVSADTVKIVSDSTYAPFEFKDSDQVYKGIDVDIIKKAAEMSGWNYKMTFPGFDAAVNAVQSGQADALMAGTTVTKEREKVFTFSHTYYDTKIVIATRKQDKITKYSQLKGKTVGVKNGTAAQSFLEKHQDKYGYKIKSFDTGDSMYNSLESASVDAVMDDKAVAQYAINQGQNLRIEMDGESIGSFAFAVKKGSKYEYLIKDFNKALKKMKADGSYDEIMTKWISAKSKTDEQSKTKETGDAKAKAKPVKSSYKVVMDSSFAPFEFQNDAGQYVGIDVELIKAIAKQQGFKIKTENPGFDAALNTVQSSQADAVMAGMSITDDRKKIFDFSDPYYTSNTLLAVRKGSNVVSYKDLKGKKVGAKNGTASYTFLEKNKAKYGYTLKSFDEASTMYDSLNSGSIYALMDDEAVLKYAIQQGRKFETPIPGEKSGEYGFAVKKGSSPELIQMFNNGLAALKKSGQYDKIINKYLSDKKKDAKSESSVDESTIFGLLSNNYKQLLSGLGTTLSLVILSFALAMIVGILFGMMSVSPYKTLRIIASIFVDVVRGIPLMIVAAFIFWGIPNLIESITGHQSPINDFVAGTIALTLNGGAYIAEIVRGGIEAVPSGQMEASRSLGISYKTTMKRIILPQAFKLMLPNFINQFVISLKDTTIISAIGLIELFQAGKIIIARNYQSFRMYAILAIMYLVIITLLTRLAKRLEKRIK","752006","For other components see SMu0731 (NBD1).For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0328 (glnR);SMu0329 (glnA); SMu0741 (glnH);SMu1080 (glnP);SMu1509 (glnB);SMu1380 (glnQ);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP). ","glutamine ABC transporter, permease and solute binding protein","Membrane, Periplasm","Several matches in gapped BLAST to ABC transporter amino acid-binding protein / permease proteins: residues 1-728 are 66% similar to the protein in S.pneumoniae (gi15458747) and are 70% similar to the protein in S.agalactiae (gi14211227).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1466 (0.0).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[521-728]T$	BPD_transp_1
PS50928	$\"[525-720]T$	ABC_TM1

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[28-248]T$ $\"[275-494]T$	SBP_bac_3
SM00062	$\"[27-249]T$ $\"[274-495]T$	PBPb

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[517-622]T$	HEQRo_perm_3TM

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[25-159]T$ $\"[272-396]T$	G3DSA:3.40.190.10
PTHR18966	$\"[332-358]T$	Glut_Rec_Related
PTHR18966:SF35	$\"[332-358]T$	PTHR18966:SF35
SSF53850	$\"[23-246]T$ $\"[270-492]T$	SSF53850

","BeTs to 8 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","***** IPB001638 (Bacterial extracellular solute-binding proteins, family 3) with a combined E-value of 5.5e-15. IPB001638A 293-302 IPB001638B 325-356 IPB001638A 46-55","Residues 656-716 are 50% similar to a (TRANSPORT PERMEASE ABC TRANSPORTER) protein domain (PD006016) which is seen in Q9CES5_LACLA.Residues 533-584 are 63% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC COMPLETE) protein domain (PD001196) which is seen in Q9CES5_LACLA.Residues 400-491 are 42% similar to a (PROTEOME BINDING COMPLETE SUBSTRATE) protein domain (PD395210) which is seen in Q9CES5_LACLA.Residues 266-398 are 49% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT ABC TRANSPORTER) protein domain (PD245531) which is seen in Q9CES5_LACLA.Residues 658-709 are 38% similar to a (PERMEASE TRANSPORT TRANSPORTER ABC) protein domain (PD383635) which is seen in P73544_SYNY3.Residues 598-654 are 71% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in Q9CES5_LACLA.Residues 659-726 are 33% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE SYSTEM INNER PROTEOME) protein domain (PD415578) which is seen in Q9KLI6_VIBCH.Residues 271-491 are 21% similar to a (PROTEOME COMPLETE BINDING GLUTAMINE) protein domain (PD168496) which is seen in Q9Z7V0_CHLPN.Residues 357-492 are 42% similar to a (RECEPTOR GLUTAMATE PRECURSOR SIGNAL SUBUNIT CHANNEL) protein domain (PD000500) which is seen in Q9CES5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 12:03:38 2007","Thu Aug 10 10:57:35 2006","Thu Aug 10 10:57:35 2006","Wed Dec 19 08:23:59 2001","Wed Dec 19 08:23:59 2001","Wed Dec 19 08:23:59 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0732 is paralogously related (blast p-value < 1e-3) to SMu0219, SMu0516, SMu1382, SMu1080, SMu1111, SMu1383, SMu0417, SMu0739, SMu0741, SMu0848, SMu1078, SMu0847, SMu1381, SMu1112, SMu0416, SMu0846, SMu1765, SMu0970,SMu1426,all predicted amino acid ABC transporters, amino acid substrate-binding proteins, and to SMu0331,a predicted glutamate synthase small subunit.","Mon Jan 14 14:19:47 2002","Thu Aug 10 10:57:35 2006","pdb1WDNA Chain A, Glutamine-Binding Protein >gi1943541pdb1... 116 6e-027pdb1HSLA Chain A, Histidine-Binding Protein Complexed With L-... 106 9e-024pdb2LAO Lysine-, Arginine-, Ornithine-Binding Protein (Lao... 101 3e-022","SMU.806c","","Residues 28 to 248 (E-value = 2.6e-70) place SMu0732 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)Residues 275 to 494 (E-value = 1e-75) place SMu0732 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)Residues 521 to 728 (E-value = 3.8e-29) place SMu0732 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Thu Aug 10 10:57:35 2006","24379263","","","","","","1","","","SMU.806c","155" "SMu0733","754378","755295","918","ATGTCTAAGAAAAGAATGTTAGAAAGTTACACTCACCGTTATGAACATTTCCCAGCTTGGCTGACCATTCTAATTGCCTGTGTCATGGTTGTTCTATTTTTTCTTTTGGGGCAACTAGGAGGCGGATTTTTAGTTGGTTTGCTGAGTGTGCCTTTCATTGTTCTAAAACCGGAGATGGCTAATAGTTTTTTTAATTCTATTTTTTTTCAATTGGGTTTGTTTATTTTTGTGGCGCTGATAAATTTTGCTTGGGTCAAATGGTATGAGAAGCGATCAATTGCCAGTTTAGGATTTTTCAAGAAGCAATGGTTTCTTGAAATCCTCAAGGGATGGGGAGTTGGAATGGGAATTTTTTCCTTTGCTTTTTTGTTGACTTATCTGTTTGGTGGTGTGGAGTTGCAGGTTATTGATTTTTCTGGAACAGCTGTTCTTTATATCTTATCAATTATCCCATTTTGGTTTATTCAGAGTGGGACAGAAGAGTTGCTGACACGCGGTTGGCTCTTGCCGATTATCAATAAGCGCAGTAATTTGCCTGTAGCTATTGGAATTTCCAGCAGTCTGTTTGGACTCATGCATTTGGCTAATAGCCACGTCACAGTCTTTTCAATTATGAGCATTATTTTATCTGGAATTTTTATGGCACTGTACATGCTGAAAACAGATAATCTTTGGGGAGTAGCAGGTCTTCACGGAGCCTGGAATTTTACGCAAGGCAATATCTTTGGAGTTGCGGTTAGTGGGATGGATACAGGCAGATCACTGTTTCGTTTTGTGAATAAGGCTAATGCAGCAAAGTGGGTCTCAGGCGGCCAGTTTGGGACAGAAGGTAGCCTATTAACCAGTCTTGTTCTTCTTGTAGGAATTATCGTGCTTGTTCTTTTGCTCAAGAAAGACCTGACTGTCAAAAGGCCTTAA","10.60","11.14","33995","MSKKRMLESYTHRYEHFPAWLTILIACVMVVLFFLLGQLGGGFLVGLLSVPFIVLKPEMANSFFNSIFFQLGLFIFVALINFAWVKWYEKRSIASLGFFKKQWFLEILKGWGVGMGIFSFAFLLTYLFGGVELQVIDFSGTAVLYILSIIPFWFIQSGTEELLTRGWLLPIINKRSNLPVAIGISSSLFGLMHLANSHVTVFSIMSIILSGIFMALYMLKTDNLWGVAGLHGAWNFTQGNIFGVAVSGMDTGRSLFRFVNKANAAKWVSGGQFGTEGSLLTSLVLLVGIIVLVLLLKKDLTVKRP","755294","","conserved hypothetical protein (possible membrane protein)","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein;possible membrane protein: residues 71-276 are 43% similar to the conserved hypothetical protein in S.pneumoniae (gi|15903162|).Residues 110-276 are 32% similar to the membrane protein from S.coelicolor(gi|7481590|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1465 (9e-71).","

InterPro
IPR003675
Family

Abortive infection protein
PF02517	$\"[147-242]T$	Abi

noIPR
unintegrated

unintegrated
PS51257	$\"[1-27]T$	PROKAR_LIPOPROTEIN

","BeTs to 3 clades of COG1266COG name: Predicted membrane proteinFunctional Class: SThe phylogenetic pattern of COG1266 is --T--qvC-BR-----o-in-Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 110-276 are 32% similar to a (TRANSMEMBRANE) protein domain (PD200676) which is seen in Q9ZBV0_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:57:20 2002","Sat Oct 12 10:57:20 2002","Sat Oct 12 10:57:20 2002","Wed Dec 19 08:43:33 2001","","Wed Dec 19 08:43:33 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0733 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 08:44:12 2001","","No significant hits to the NCBI PDB database.","SMU.807","","Residues 147 to 242 (E-value = 1e-11) place SMu0733 in the Abi family which is described as CAAX amino terminal protease family (PF02517)","Wed Dec 19 08:43:33 2001","24379264","","","","","","1","","","SMU.807","951" "SMu0734","755492","757483","1992","ATGATAGATAGGAAAGATAATAACCAGTTTCATCTGGTTTCAAAATATGAGCCGTCTGGTGATCAGCCTGAGGCCATTGAGGCTTTGGTTGACAATATTGAAGGTGGTGAGAAAGCGCAAATTCTCAAAGGGGCGACTGGGACGGGAAAAACCTATACCATGAGCCAAGTTATTCAAAAAGTCAATAAACCGACTTTAGTCATCGCTCATAATAAAACTCTAGCTGGTCAGCTTTACGGTGAATTTAAAGAATTTTTCCCAGATAATGCAGTTGAGTATTTTGTTTCTTACTATGATTATTATCAGCCTGAAGCCTATGTGCCATCAAGTGATACCTATATTGAAAAGGATAGTTCAGTTAATGATGAGATTGATAAGCTCCGACATTCGGCAACATCTGCCCTTTTGGAACGCAATGATGTCATTGTCGTAGCATCCGTCTCCTGTATTTATGGTTTAGGGTCACCCAAGGAATATGCAGATAGCGTGGTTAGTCTGCGGCCCAGTCAGGAGATTTCTCGCGACCAACTGTTAAATGATTTGGTAGATATTCAGTTTGAGCGCAACGATATTGATTTCCAGCGGGGACGTTTTCGTGTGCGCGGCGATGTGGTGGAAATTTTTCCAGCATCACGTGATGAACATGCTTTTCGTGTGGAATTTTTCGGTGATGAGATTGATCGTATCAGAGAAATTGAGAGTTTAACAGGTCGTGTTCTTGGTGAAGTAGATCACTTGGCTATTTTTCCAGCAACTCACTTTATGACTAACGATGAGCACATGGAAGTGGCTATTGCCAAGATTCAAAAGGAAATGAAAGAGCAAGTCAGGCTTTTTGAAGCAGAAGGGAAATTGATTGAAGCACAGCGTATTCGCCAAAGAACAGAGTATGATGTGGAAATGCTGCGGGAGATGGGCTATACTAGCGGCGTTGAAAACTATTCGCGTCATATGGATGGCCGCAGTGAGGGAGAACCGCCTTATACACTTCTTGACTTTTTTCCAGAGGATTTCCTCATCATGATTGATGAAAGCCACATGACTATGGGGCAGATTAAAGGTATGTATAATGGTGACCGATCGCGCAAGGAGATGTTGGTCAACTATGGTTTTCGTCTGCCAAGTGCGCTGGACAATCGACCGCTGCGTCGAGAAGAATTTGAAAGCCATGTCCATCAGATTGTCTATGTTTCAGCAACACCAGGTGACTATGAGATGGAGCAGACGGACACGGTTATTGAGCAAATTATCCGTCCGACTGGTCTCTTGGACCCAGAAGTGGAAGTTCGGCCAACCATGGGACAAATGGATGACTTGCTGGGTGAAATCAATACGCGTGCTGATAAGGGCGAGCGGACCTTTATTACAACCTTAACCAAGAAAATGGCGGAAGATTTGACTGACTACCTCAAGGAAATGGGTGTCAAGGTCAAGTACATGCATTCTGACATCAAGACTCTGGAACGTACTGAAATTATCCGCGACCTTCGTTTAGGTGTTTTTGATGTTCTTATCGGTATCAATTTGCTGCGCGAAGGTATTGATGTGCCAGAGGTTAGTCTGGTTGCCATTCTTGATGCAGACAAAGAAGGTTTTCTCCGCAATGAACGTGGTCTTATCCAGACCATTGGACGGGCTGCGCGCAACAGTCAAGGACATGTTATTATGTATGCTGATACTGTGACGCAGTCCATGCGTCGCGCTATTGATGAGACCCACCGCCGCCGCCAAATCCAAATGGCTTACAATGAAGAGCATGGTATTATTCCACAAACCATCAAAAAAGATATCCGCGATCTTATCGCGATTACAAAAGCAAATGACTCTGAAGTGGCTGAGGAGGCTGTGGATTATAATGCAATGACCAAATCTGAACGTCAAGAAGCCATCAAGAAACTGCAAAAACAAATGCAAGAAGCAGCTGAACTGCTTGATTTTGAACTGGCTGCTCAAATCCGCGATATGGTTTTAGAATTGAAGGCGATGGATTAG","4.70","-35.32","76019","MIDRKDNNQFHLVSKYEPSGDQPEAIEALVDNIEGGEKAQILKGATGTGKTYTMSQVIQKVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSALLERNDVIVVASVSCIYGLGSPKEYADSVVSLRPSQEISRDQLLNDLVDIQFERNDIDFQRGRFRVRGDVVEIFPASRDEHAFRVEFFGDEIDRIREIESLTGRVLGEVDHLAIFPATHFMTNDEHMEVAIAKIQKEMKEQVRLFEAEGKLIEAQRIRQRTEYDVEMLREMGYTSGVENYSRHMDGRSEGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDRSRKEMLVNYGFRLPSALDNRPLRREEFESHVHQIVYVSATPGDYEMEQTDTVIEQIIRPTGLLDPEVEVRPTMGQMDDLLGEINTRADKGERTFITTLTKKMAEDLTDYLKEMGVKVKYMHSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSQGHVIMYADTVTQSMRRAIDETHRRRQIQMAYNEEHGIIPQTIKKDIRDLIAITKANDSEVAEEAVDYNAMTKSERQEAIKKLQKQMQEAAELLDFELAAQIRDMVLELKAMD","757482","For other 'uvr' genes see SMu1136 (uvrC) and SMu1686 (uvrA).For the subunit A sequence (uvrA) see SMu1686.For the subunit C sequence (uvrC) see SMu1136.From Genbank:[gi:2499101]The ABC excision nuclease is a DNA repair enzyme that catalyzes the excision reaction of UV-damaged nucleotide segments producing oligomers having the modified bases.UVRB stimulates the ATPase activity of UVRA in the presence of UV-irradiated double-stranded DNA.It also enhances the ability of UVRA to bind to UV-irradiated duplex DNA. ","excinuclease ABC (subunit B); helicase subunit of the DNA excision repair complex","Cytoplasm","Several matches in gapped BLAST to dnaA proteins: residues 1-663 are 87% similar to the enzyme in S.pneumoniae (gi15903161)and are 84% similar to the protein from S.pyogenes (gi15675262).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1464 (0.0).","

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[469-550]T$	Helicase_C
SM00490	$\"[464-550]T$	HELICc
PS51194	$\"[435-601]T$	HELICASE_CTER

InterPro
IPR001943
Domain

UvrB/UvrC protein
PF02151	$\"[627-662]T$	UVR
PS50151	$\"[627-662]T$	UVR

InterPro
IPR004807
Family

Excinuclease ABC, B subunit
TIGR00631	$\"[9-660]T$	uvrb

InterPro
IPR006935
Family

Type III restriction enzyme, res subunit
PF04851	$\"[15-89]T$	ResIII

InterPro
IPR009055
Domain

UvrB, C-terminal UvrC-binding
SSF46600	$\"[612-661]T$	UvrB_C

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[14-430]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[31-188]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[10-178]T$ $\"[293-415]T$ $\"[416-583]T$	G3DSA:3.40.50.300
G3DSA:4.10.860.10	$\"[605-661]T$	G3DSA:4.10.860.10
PTHR10967	$\"[452-526]T$	PTHR10967
PTHR10967:SF62	$\"[452-526]T$	PTHR10967:SF62

","BeTs to 13 clades of COG0556COG name: Helicase subunit of the DNA excision repair complexFunctional Class: LThe phylogenetic pattern of COG0556 is --t--qVcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001943 (UvrB/uvrC motif) with a combined E-value of 3.6e-18. IPB001943A 40-49 IPB001943B 508-517 IPB001943C 633-660","Residues 454-505 are 50% similar to a (B PROTEOME SUBUNIT COMPLETE) protein domain (PD382021) which is seen in Q9PR24_UREPA.Residues 93-178 are 59% similar to a (B ATP-BINDING SUBUNIT EXCINUCLEASE) protein domain (PD391901) which is seen in UVRB_METTH.Residues 592-663 are 58% similar to a (RESPONSE ATP-BINDING SUBUNIT EXCINUCLEASE) protein domain (PD267810) which is seen in UVRB_LACLA.Residues 453-505 are 47% similar to a (B ATP-BINDING SUBUNIT EXCINUCLEASE) protein domain (PD382039) which is seen in UVRB_MYCPU.Residues 233-334 are 37% similar to a (B PROTEOME SUBUNIT COMPLETE) protein domain (PD334295) which is seen in Q9PR24_UREPA.Residues 106-332 are 91% similar to a (ATP-BINDING REPAIR DNA SUBUNIT) protein domain (PD002798) which is seen in UVRB_STRPN.Residues 22-92 are 92% similar to a (EXCINUCLEASE SUBUNIT ABC ATP-BINDING) protein domain (PD133659) which is seen in UVRB_STRPN.Residues 333-452 are 92% similar to a (SUBUNIT ABC EXCINUCLEASE EXCISION) protein domain (PD186159) which is seen in UVRB_STRPN.Residues 561-591 are 74% similar to a (B ATP-BINDING SUBUNIT EXCINUCLEASE) protein domain (PD381677) which is seen in UVRB_LACLA.Residues 506-591 are 94% similar to a (EXCINUCLEASE SUBUNIT ABC EXCISION) protein domain (PD099792) which is seen in UVRB_STRPN.Residues 454-505 are 88% similar to a (HELICASE ATP-BINDING RNA RNA-BINDING ATP-DEPENDENT) protein domain (PD000033) which is seen in UVRB_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 10 10:52:22 2006","Wed Dec 19 08:45:25 2001","Thu Aug 10 10:52:22 2006","Wed Dec 19 08:45:25 2001","Wed Dec 19 08:45:25 2001","Wed Dec 19 08:45:25 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0734 is paralogously related (blast p-value < 1e-3) to SMu0006, SMu1669, SMu0557, and SMu0434 predicted helicases and replication factors. ","Thu Jan 24 12:36:32 2002","Thu Aug 10 10:52:22 2006","pdb1D9ZA Chain A, Crystal Structure Of The Dna Repair Protein... 922 0.0pdb1D9XA Chain A, Crystal Structure Of The Dna Repair Protein... 917 0.0pdb1C4OA Chain A, Crystal Structure Of The Dna Nucleotide Exc... 704 0.0","SMU.809","","Residues 469 to 550 (E-value = 7.6e-20) place SMu0734 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)Residues 627 to 662 (E-value = 7.1e-09) place SMu0734 in the UVR family which is described as UvrB/uvrC motif (PF02151)","Thu Aug 10 10:52:22 2006","24379265","","","Sicard,N., Oreglia,J. and Estevenon,A.M.Structure of the gene complementing uvr-402 in Streptococcuspneumoniae: homology with Escherichia coli uvrB and the homologousgene in Micrococcus luteusJ. Bacteriol. 174 (7), 2412-2415 (1992)PubMed: 1551859Cheo,D.L., Bayles,K.W. and Yasbin,R.E.Cloning and characterization of DNA damage-inducible promoterregions from Bacillus subtilisJ. Bacteriol. 173 (5), 1696-1703 (1991)PubMed: 1847907Backendorf,C., Spaink,H., Barbeiro,A.P. and van de Putte,P.Structure of the uvrB gene of Escherichia coli. Homology with other DNA repair enzymes and characterization of the uvrB5 mutationNucleic Acids Res. 14 (7), 2877-2890 (1986)PubMed: 3008099Arikan,E., Kulkarni,M.S., Thomas,D.C. and Sancar,A.Sequences of the E. coli uvrB gene and proteinNucleic Acids Res. 14 (6), 2637-2650 (1986)PubMed: 3515321Sohi,M., Alexandrovich,A., Moolenaar,G., Visse,R., Goosen,N.,Vernede,X., Fontecilla-Camps,J.C., Champness,J. and Sanderson,M.R.Crystal structure of Escherichia coli UvrB C-terminal domain, and a model for UvrB-uvrC interactionFEBS Lett. 465 (2-3), 161-164 (2000)PubMed: 10631326","","Wed Dec 19 08:56:01 2001","1","","","SMU.809","154" "SMu0735","757851","758147","297","TTGACTAGGAAAACGTTTCAGGTCAAACAAAAACAGCTGTTTTGGCTCTATGTCATCTTAATTTTAGCTGCTATCAGCCTGCCTTGGCATTACCATTGGACTGATTTACCAGTGACCTATTATTTGCTGTTTACAACGGTGTCAGTCATCTGCATTTGGCAGGATTACCTTATTTTCGGTCTTTTTCAGCGCTATTTACAGCAAGAATTATCTTTTAAGTGGCGAATCGTTTTTTATCGTTTTTGTTTATATCGGGACATTTTCTTTATATTTCACATTTTGGAAACAGTCCTTTAA","9.90","4.60","12267","MTRKTFQVKQKQLFWLYVILILAAISLPWHYHWTDLPVTYYLLFTTVSVICIWQDYLIFGLFQRYLQQELSFKWRIVFYRFCLYRDIFFIFHILETVL","758146","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu0735 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-28]?$	signal-peptide
tmhmm	$\"[13-31]?$ $\"[41-61]?$ $\"[76-94]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-15]?$	signal-peptide
tmhmm	$\"[21-36]?$	transmembrane_regions

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[9-63]T$	HTH_3
SM00530	$\"[8-63]T$	HTH_XRE
PS50943	$\"[9-63]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[4-75]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[3-75]T$	G3DSA:1.10.260.40

","BeTs to 5 clades of COG1396COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1396 is --T--qV-EBR---------xNumber of proteins in this genome belonging to this COG is 6","No significant hits to the Blocks database.","Residues 8-63 are 55% similar to a (COMPLETE PROTEOME REGULATOR) protein domain (PD000418) which is seen in Q46240_CLOPE.Residues 9-66 are 46% similar to a (REPRESSOR COMPLETE PROTEOME) protein domain (PD027337) which is seen in Q9CJI6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 10:59:36 2002","Sat Oct 12 10:59:36 2002","Sat Oct 12 10:59:36 2002","Wed Dec 19 08:59:13 2001","","Wed Dec 19 08:59:13 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0737 is paralogously related (blast p-value < 1e-3) to SMu0366 and SMu0197,both predicted conserved hypothetical proteins / possible transcriptional regulators, SMu0717,a predicted conserved hypothetical protein, SMu1842,a predicted conserved hypothetical protein (probable transcriptional regulator/repressor protein) SMu1795,a predicted transcriptional regulator/repressor and SMu0056, a predicted transcriptional regulator.","Thu Jan 17 11:15:05 2002","","No significant hits to the NCBI PDB database.","SMU.813","","Residues 9 to 63 (E-value = 3.8e-18) place SMu0737 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Wed Dec 19 08:59:13 2001","24379268","","","","","","1","","","SMU.813","" "SMu0738","759399","759863","465","GTGTCCCGTACCTCTCAAGTCATCCTAACTAATATGTGTTTAATTGAAGACGGCAATGGAAATATTGTTATGCAAATTCGTGATCCTAAGCGTTATTCTTGGTCTGGTGCTGCCCTGCCTGGCGGGCACATTGAAGAACATGAAGGTTTAGTGGAATCTGTTATTCGCGAAGTCAAAGAAGAGACAGGATTAACCATTCATCATCCACAGTTGGTTGGGATGAAGCATTGGTATACCAAGGAAGATGTTCGTTATCTGGTTTTTCTTTATCGGACATCTGATTTTGAAGGTGACTTGCAGTCTTCTGCTGAAGGACAAGTGCGTTGGGTAGCAAGAAAAGAGTTGGCAGAGCTTGATTTGGCTTATGATATGCTTAATCTGCTGCGCGTGTTTGAAGAAAAAAACTTATCTGAACTCTTTTATCGTGAACGCCTAGCAGATGATTTTGTCAAAGAGTTTTGGTAA","4.90","-7.84","17977","MSRTSQVILTNMCLIEDGNGNIVMQIRDPKRYSWSGAALPGGHIEEHEGLVESVIREVKEETGLTIHHPQLVGMKHWYTKEDVRYLVFLYRTSDFEGDLQSSAEGQVRWVARKELAELDLAYDMLNLLRVFEEKNLSELFYRERLADDFVKEFW","759862","For other 'mut' genes associated with repair and DNA mutation, see Smu0510; SMu0024 (mutT); SMu1697 (mutY);SMu1700 (mutS2);SMu1291 (mutT); SMu1325 (mutX); SMu1371 (mutR); SMu1468 (mutM); SMu0824 (mutT) and SMu0825 (mutT).","MutT/nudix family protein","Cytoplasm","Matches in gapped BLAST to MutX:residues 9-110 are 26% similar to the previously published enzyme in S.mutans (gi1813348)Residues 1-154 are 50% similar to the protein in S.pneumoniae (gi15901097).Residues 6-141 are 44% similar to the protein from Lactococcus lactis subsp. lactis (gi15673103)The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1196 (4e-05).","

InterPro
IPR000086
Domain

NUDIX hydrolase
PR00502	$\"[37-51]T$ $\"[51-66]T$	NUDIXFAMILY
G3DSA:3.90.79.10	$\"[5-134]T$	no description
PF00293	$\"[7-134]T$	NUDIX

InterPro
IPR002667
Family

Isopentenyl-diphosphate delta-isomerase
PD004109	$\"[17-104]T$	Q8A0P9_BACTN_Q8A0P9;

noIPR
unintegrated

unintegrated
PTHR22769	$\"[12-141]T$	MUTT/NUDIX HYDROLASE

","BeTs to 7 clades of COG0494COG name: NTP pyrophosphohydrolases (MutT family) including oxidative damage repair enzymesFunctional Class: L,RThe phylogenetic pattern of COG0494 is a-T-YqvCEBRHuj---linxNumber of proteins in this genome belonging to this COG is 6","***** IPB000086 (NUDIX hydrolase) with a combined E-value of 2.2e-10. IPB000086 37-63","Residues 30-74 are 55% similar to a (COMPLETE PROTEOME HYDROLASE MUTATOR MUTT/NUDIX FAMILY) protein domain (PD000653) which is seen in Q9CGH5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 11:20:42 2006","Thu Sep 14 11:20:42 2006","Tue May 3 12:02:39 2005","Wed Dec 19 09:08:31 2001","Wed Dec 19 09:08:31 2001","Wed Dec 19 09:08:31 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0738 is paralogously related (blast p-value < 1e-3) to SMu1470, a predicted conserved hypothetical and SMu1325 a predicted MutX protein.","Thu Mar 14 17:10:01 2002","","No significant hits to the NCBI PDB database.","SMU.814","","Residues 7 to 134 (E-value = 8.7e-14) place SMu0738 in the NUDIX family which is described as NUDIX domain (PF00293)","Wed Dec 19 09:08:31 2001","24379269","","","","","","1","","","SMU.814","950" "SMu0739","759971","760786","816","ATGAAAAAGCTAAAAAAAATTTTGCTGGGAATTATTGCTGCCTTAATGCTAGTCACCCTTGCTGCCTGTAGTTCGTCATCTAAGGATGATTCGCTGCAAAAAATTAAGAACAAAGGTAAGATTGTTGTTGCCATGAATCCTGAGTTTGCACCTTTTGAGTTCAAGACCTTGGTCAATGGTAAAGATACGATTGTTGGTGCCGATGTTGAAATCGCTAAGGCTATTGCCAAAGAATTGGGGGTCAAAGTTGAATTTTCTGCTATGTCTTTCAATAATGTGTTGTCCAGTGTTCAATCTGGCAAAGCAGATATTGGTATTTCAGGAATTTCTGCCACAAAAGAACGTCAAAAAGTTTATGACTTTTCAGATACTTATTATGAATCTGTCAATGTTGTTATTGTTAAAAAATCAGAATTAGCTAAATATAAGAAAACCAATTCTCTCAAGGGTTTATCAGTAGCCACTCAAAAAGGAACAATCCAAGAAACCGTTGCTAAGGAGCAATTAACGGGTGCTAAAATCGTTTCTCTTGTCCAAAATGGTGAAATGATTAATGAATTGAAATCAGGTCAAGTCAATGGCGTTGTTTTAGAAAAGCCAATTGCGGAAGGTTATGTTGCTAAAAACGATGATTTGGCTATTGCTCAAATTAAGTTAAAATCAAGTTCATCAGATGCTTATGCTGTAGCTATGCCTAAGGGAAGCAGTGCACTTAAGAAGAAAGTGGATAAAGTTATCAAAAAACTTAAAAAAGCAAATAAGATTGATAAGTTTGTCAAAGATGCCTATAATTTATCTGTATCAGGTGGGAAATAA","10.50","17.95","29028","MKKLKKILLGIIAALMLVTLAACSSSSKDDSLQKIKNKGKIVVAMNPEFAPFEFKTLVNGKDTIVGADVEIAKAIAKELGVKVEFSAMSFNNVLSSVQSGKADIGISGISATKERQKVYDFSDTYYESVNVVIVKKSELAKYKKTNSLKGLSVATQKGTIQETVAKEQLTGAKIVSLVQNGEMINELKSGQVNGVVLEKPIAEGYVAKNDDLAIAQIKLKSSSSDAYAVAMPKGSSALKKKVDKVIKKLKKANKIDKFVKDAYNLSVSGGK","760785","","amino acid ABC transporter, periplasmic amino acid-binding protein","Membrane, Periplasm, Extracellular","Matches in gapped BLAST to ABC transporter solute-binding protein - amino acid transport: residues 20-267 are 49% similar to the protein in S.pneumoniae (gi|15902145|). Residues 20-235 are 55% similar to the protein from S.pyogenes (gi|15674823|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1431 (7e-67).","

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[41-251]T$	SBP_bac_3
SM00062	$\"[40-262]T$	PBPb

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[38-167]T$	G3DSA:3.40.190.10
PTHR18966	$\"[101-138]T$	Glut_Rec_Related
PTHR18966:SF20	$\"[101-138]T$	PTHR18966:SF20
PS51257	$\"[1-23]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[1-260]T$	SSF53850

InterPro
IPR001176
Family

1-aminocyclopropane-1-carboxylate synthase
PR00753	$\"[82-102]T$ $\"[213-237]T$	ACCSYNTHASE

InterPro
IPR004838
Binding_site

Aminotransferases class-I pyridoxal-phosphate-binding site
PS00105	$\"[219-232]T$	AA_TRANSFER_CLASS_1

InterPro
IPR004839
Domain

Aminotransferase, class I and II
PF00155	$\"[58-240]T$	Aminotran_1_2

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[44-268]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015422
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 2
G3DSA:3.90.1150.10	$\"[322-371]T$	PyrdxlP-dep_Trfase_major_sub2

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[2-365]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[58-367]T$	PTHR11751
PTHR11751:SF25	$\"[58-367]T$	PTHR11751:SF25

","BeTs to 14 clades of COG0436COG name: PLP-dependent aminotransferasesFunctional Class: EThe phylogenetic pattern of COG0436 is AMTKYQVCEBRhUJ---linxNumber of proteins in this genome belonging to this COG is 4","***** IPB001511 (Aminotransferases class-I) with a combined E-value of 7e-15. IPB001511A 58-68 IPB001511B 157-171 IPB001511C 219-232","Residues 84-195 are 62% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9KGV1_LACLA.Residues 1-83 are 49% similar to a (PROTEOME TRANSFERASE COMPLETE ORFT) protein domain (PD090155) which is seen in Q9CE18_LACLA.Residues 320-369 are 60% similar to a (AMINOTRANSFERASE ASPARTATE PROTEOME COMPLETE PYRIDOXAL) protein domain (PD000894) which is seen in O53091_LACSK.Residues 86-196 are 28% similar to a (AMINOTRANSFERASE TRANSAMINASE ALANINE) protein domain (PD358273) which is seen in ALAT_SCHPO.Residues 248-369 are 29% similar to a (TRANSFERASE AMINO-TRANSFERASE) protein domain (PD298528) which is seen in Q9L3V1_STRRO.Residues 207-275 are 54% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL ASPARTATE COMPLETE) protein domain (PD188985) which is seen in Q9CE18_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:02:33 2002","Thu Jan 24 12:49:17 2002","Sat Oct 12 11:02:33 2002","Wed Dec 19 09:24:12 2001","Wed Dec 19 09:24:12 2001","Wed Dec 19 09:24:12 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0740 is paralogously related (blast p-value < 1e-3) to SMu0020, SMu1663, SMu1199, and SMu1526, all predicted aminotransferases.","Thu Jan 24 12:49:17 2002","Wed Dec 19 09:24:12 2001","pdb|1BKG|A Chain A, Aspartate Aminotransferase From Thermus The... 100 5e-022pdb|1BJW|A Chain A, Aspartate Aminotransferase From Thermus The... 98 2e-021pdb|1BW0|B Chain B, Crystal Structure Of Tyrosine Aminotransfer... 74 3e-014","SMU.816","","Residues 73 to 368 (E-value = 2.6e-18) place SMu0740 in the Aminotran_1_2 family which is described as Aminotransferase class I and II (PF00155)","Wed Dec 19 09:24:12 2001","24379271","","","Zuniga,M., Champomier-Verges,M., Zagorec,M. and Perez-Martinez,G.Structural and functional analysis of the gene cluster encoding the enzymes of the arginine deiminase pathway of Lactobacillus sakeJ. Bacteriol. 180 (16), 4154-4159 (1998)PubMed: 9696763","","Wed Dec 19 09:26:19 2001","1","","","SMU.816","" "SMu0741","762171","762986","816","ATGACATTTAAAAAGTTAGTTTTAGGTTTGTTGAGTTTTGTGGCTGTATTTACTTTAGTAGCTTGCAGTTCTTCTAATTCAAAAAATTTACAGGATGATATTAAAGAAAAGAAAAAGTTAGTTGTTGCTGTTAGTCCGGACTATGCTCCTTTTGAGTTCAAGGCTCTTGTGAACGGTAAGGATACTGTTGTTGGTGCTGATATTGATTTGGCAAAAGCAATTGCTAAAGAATTGGGAGTGAAACTGGAATTATCTTCCATGAGTTTTGATAATGTCTTGTCCAGTTTAAAAACAGGAAAAGCAGACATAGCTATCTCTGGTTTATCTTATACCAAGGAACGTGCTCAAGCCTATGACTTTTCAGAAGCTTATTATAAAACGGAAAATGCTATTCTTATTAAAAAGTCTGATTTGAACAAATATACAATGATTTCTTCTTTTAATAATAAGACTAAAGTAGCTGTTCAAAAAGGAACGATTGAAGAAGGATTAGCTAAAAATCAATTAAAACAATCAAACATTACCTCTTTGACTTCGATGGGCGAAGCTGTTAATGAGCTCAAATCTGGTCAGGTTGATGCTATTGATCTTGAAAAACCAGTGGCAGAAGGTTATGTGTCTCAAAATAGTGATTTGGTTCTTGCCAAAGTTGCCTTAAAAACGGGTGAAGGGGATGCCAAAGCAGTTGCTCTGCCTAAAGACAGTGGTCAATTAGTTAAGACGGTGAATAAGGTTATTAAGAAACTCAAAAAAGAAGATAAATACAAGCAGTTTATCAGCGATGCTGTTAAATTAACTGGTCAGCAAGTGGATTGA","9.90","6.96","29333","MTFKKLVLGLLSFVAVFTLVACSSSNSKNLQDDIKEKKKLVVAVSPDYAPFEFKALVNGKDTVVGADIDLAKAIAKELGVKLELSSMSFDNVLSSLKTGKADIAISGLSYTKERAQAYDFSEAYYKTENAILIKKSDLNKYTMISSFNNKTKVAVQKGTIEEGLAKNQLKQSNITSLTSMGEAVNELKSGQVDAIDLEKPVAEGYVSQNSDLVLAKVALKTGEGDAKAVALPKDSGQLVKTVNKVIKKLKKEDKYKQFISDAVKLTGQQVD","762985","For other 'glt' genes see SMu0296 (gltX); SMu0330 (gltA),(gltB) and SMu0331 (gltD).For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0329 (glnA);SMu1080 (glnP);SMu1509 (glnB); SMu1380 (glnQ);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP).","amino acid ABC transporter, substrate-binding protein","Membrane, Periplasm","Several matches in gapped BLAST to ABC transporter (substrate-binding protein): residues 1-266 are 58% similar to the protein in S.pyogenes (gi15674823). Residues 1-238 are 54% similar to the protein from S.pneumoniae (gi15903294).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1431 (3e-96).","

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[40-251]T$	SBP_bac_3
SM00062	$\"[39-262]T$	PBPb

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[35-177]T$	G3DSA:3.40.190.10
PTHR18966	$\"[57-147]T$	Glut_Rec_Related
PS51257	$\"[1-22]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[1-260]T$	SSF53850

","BeTs to 9 clades of COG0834COG name: Periplasmic amino acid binding proteinsFunctional Class: EThe phylogenetic pattern of COG0834 is A-----VCEBrHUJ---LINxNumber of proteins in this genome belonging to this COG is 8","***** IPB001638 (Bacterial extracellular solute-binding proteins, family 3) with a combined E-value of 1.4e-12. IPB001638A 61-70 IPB001638B 93-124","Residues 57-140 are 30% similar to a (RECEPTOR GLUTAMATE SIGNAL PRECURSOR SUBUNIT) protein domain (PD000273) which is seen in O57423_OREMO.Residues 42-144 are 57% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT ABC TRANSPORTER) protein domain (PD245531) which is seen in Q9CI05_LACLA.Residues 152-238 are 43% similar to a (PROTEOME BINDING COMPLETE SUBSTRATE) protein domain (PD396753) which is seen in Q9CI05_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 10:49:39 2006","Thu Aug 31 10:47:06 2006","Thu Aug 31 10:47:06 2006","Wed Dec 19 11:06:50 2001","Wed Dec 19 11:06:50 2001","Wed Dec 19 11:06:50 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0741 is paralogously related (blast p-value < 1e-3) to SMu0739, SMu1078, SMu0732, SMu1381, SMu0219, SMu0416, SMu1765, SMu1112, SMu0846, and SMu1764, all predicted permeases.","Thu Jan 24 12:51:30 2002","Thu Aug 31 10:47:06 2006","pdb1WDNA Chain A, Glutamine-Binding Protein >gi1943541pdb1... 101 8e-023pdb1HSLA Chain A, Histidine-Binding Protein Complexed With L-... 77 2e-015pdb2LAO Lysine-, Arginine-, Ornithine-Binding Protein (Lao... 72 8e-014","SMU.817","","Residues 40 to 258 (E-value = 2e-54) place SMu0741 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)","Wed Dec 19 11:06:50 2001","24379272","","","","","","1","","","SMU.817","585" "SMu0742","763222","763398","177","ATGTCAAAGACAGTAGTGCGCAAAAATGAATCACTTGACGATGCTCTTCGTCGTTTCAAACGTTCTGTAACTAAAGCTGGTACACTTCAAGAATCACGCAAACGTGAATTCTACGAAAAACCTTCTGTAAAGCGCAAACGTAAATCAGAAGCAGCTCGCAAACGTAAAAAATTCTAA","11.90","14.98","6955","MSKTVVRKNESLDDALRRFKRSVTKAGTLQESRKREFYEKPSVKRKRKSEAARKRKKF","763397","For other 'rps' genes see SMu0137 (rpsO); SMu0153 (rpsI);SMu1937 (rpsD); SMu0788 (rpsP);SMu1841 (rps10); SMu1838 (rps19);SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).","30S ribosomal protein S21","Periplasm, Extracellular","Several matches in gapped BLAST to 30S ribosomal protein S21: residues 1-43 are 100% similar to the protein in S.pyogenes (gi15674824)and are 95% similar to the protein from S.pneumoniae (gi15903314).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1429 (2e-19).","

InterPro
IPR001911
Family

Ribosomal protein S21
PD005521	$\"[16-43]T$	RS21_STRPY_Q9A0H1;
PR00976	$\"[5-13]T$ $\"[13-22]T$ $\"[25-35]T$ $\"[37-47]T$	RIBOSOMALS21
PF01165	$\"[2-55]T$	Ribosomal_S21
TIGR00030	$\"[2-57]T$	S21p: ribosomal protein S21
PS01181	$\"[13-25]T$	RIBOSOMAL_S21

","BeTs to 8 clades of COG0828COG name: Ribosomal protein S21Functional Class: JThe phylogenetic pattern of COG0828 is -----q-ceb-huj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001911 (Ribosomal protein S21) with a combined E-value of 1.8e-32. IPB001911 6-48","Residues 2-43 are 90% similar to a (RIBOSOMAL 30S DNA GENOMIC) protein domain (PD005521) which is seen in RS21_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 11:09:22 2006","Wed Dec 19 11:19:10 2001","Thu Sep 14 11:09:22 2006","Wed Dec 19 11:19:10 2001","Wed Dec 19 11:19:10 2001","Wed Dec 19 11:19:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0742 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 14:03:03 2001","","No significant hits to the NCBI PDB database.","SMU.818","","Residues 2 to 55 (E-value = 1e-30) place SMu0742 in the Ribosomal_S21 family which is described as Ribosomal protein S21 (PF01165)","Wed Dec 19 11:19:10 2001","24379273","","","Higo,K., Otaka,E. and Osawa,S.Purification and characterization of 30S ribosomal proteins fromBacillus subtilis: correlation to Escherichia coli 30S proteinsMol. Gen. Genet. 185 (2), 239-244 (1982)PubMed: 6806564Vandekerckhove,J., Rombauts,W., Peeters,B. and Wittmann-Liebold,B.Determination of the complete amino acid sequence of protein S21from Escherichia coli ribosomesHoppe-Seyler's Z. Physiol. Chem. 356 (12), 1955-1976 (1975)PubMed: 765257","","Thu Sep 14 11:09:22 2006","1","","","SMU.818","947" "SMu0743","763939","763556","384","ATGATCAAAGAATTGAAAGATTTTTTATTTAAGGGTAACGTCCTAGATCTTGCAGTAGCTGTTGTTATGGGGGCTGCTTTTAACGCCATTATCACTTCCTTAGTTTCAGATGTTATTACTCCCCTATTCCTTAACCCAGTTTTAAAAGCTGCCAATGTTAAAAATATTGCTCAGCTTTCATGGAACGGTGTTGCATATGGCAGTTTCTTAAGTGCAGTTATCAATTTTCTTATCGTTGGTACAACACTTTTCTTCGTTGTTAAAGCTGCAAACAAAGCAGTATCGCTTGGCAAGAAACAAGAGGAAGAAGCTGCAACTGAAGCTGACCCAACTGAAGTCGAATTACTTGCTGATATTAAGACGCTTCTTGAAAAACAAAACTAA","4.90","-2.01","13608","MIKELKDFLFKGNVLDLAVAVVMGAAFNAIITSLVSDVITPLFLNPVLKAANVKNIAQLSWNGVAYGSFLSAVINFLIVGTTLFFVVKAANKAVSLGKKQEEEAATEADPTEVELLADIKTLLEKQN","763561","This protein is a channel that opens in response to stretch forces in the membrane lipid bilayer.It may participate in the regulation of osmotic pressure changes within the cell [gi:6016606].","large conductance mechanosensitive channel","Membrane, Cytoplasm","Several matches in gapped BLAST to large conductance mechanosensitive channel: residues 1-126 are 60% similar to the protein in S.pyogenes (gi|15674825|)and are 56% similar to the protein from S.pneumoniae (gi|15902959|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1428 (4e-43).","

InterPro
IPR001185
Family

Large-conductance mechanosensitive channel
PD007253	$\"[4-41]T$	MS_channel
PR01264	$\"[4-18]T$ $\"[75-83]T$ $\"[84-93]T$	MECHCHANNEL
PF01741	$\"[1-126]T$	MscL
TIGR00220	$\"[1-126]T$	mscL
PS01327	$\"[11-24]T$	MSCL

noIPR
unintegrated

unintegrated
SSF81330	$\"[10-120]T$	SSF81330

","BeTs to 4 clades of COG1970COG name: Large-conductance mechanosensitive channel MscLFunctional Class: MThe phylogenetic pattern of COG1970 is -------cebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001185 (Large-conductance mechanosensitive channel mscL) with a combined E-value of 4.6e-35. IPB001185A 3-40 IPB001185B 66-96 IPB001185C 112-123","Residues 1-125 are 38% similar to a (CHANNEL MECHANOSENSITIVE) protein domain (PD007253) which is seen in Q9RH75_BRAJA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 12:52:40 2002","Wed Dec 19 14:55:49 2001","Mon Oct 28 00:59:01 2002","Wed Dec 19 14:54:52 2001","Wed Dec 19 14:54:52 2001","Wed Dec 19 14:54:52 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0743 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Dec 19 14:55:49 2001","","No significant hits to the NCBI PDB database.","SMU.819c","","Residues 1 to 126 (E-value = 2.7e-38) place SMu0743 in the MscL family which is described as Large-conductance mechanosensitive channel, MscL (PF01741)","Wed Dec 19 14:54:52 2001","","","","Moe,P.C., Blount,P. and Kung,C.Functional and structural conservation in the mechanosensitivechannel MscL implicates elements crucial for mechanosensationMol. Microbiol. 28 (3), 583-592 (1998)PubMed: 9632260Matsushita,O., Jung,C.M. and Okabe,A.Identification of the gene encoding a mechanosensitive channel MscL homologue in Clostridium perfringensGene 165 (1), 147-148 (1995)PubMed: 7489908","","Thu Dec 20 08:06:54 2001","1","","","SMU.819c","" "SMu0744","764099","765619","1521","ATGAAGAGCAGAAAACGTCAGCGAAAAGGGCTGGTTCGAAAAAATGAAATCATTATTTTAACTCTTTTTGTCGCATCAGCCGTTTCACTCTTAGCATTTACCAATTCTTTTGGGGTACTTGCTAAGAGTCTTCATCTTGAAAAAATCAATAAATCGATAACTATTTCGCTTCCTTTTGGTAAAAAAAAGATGGAACAAACAGCACGTTACTATTCAGGTGAACAGGTTCAGATCAGTTCCTCAGCTAAAAAAGACAGTCTTGGAAAAGGGCTGTCTCATTACCAAAATTGGATTGGGACAGTTAAAAAGATAAAATCACAAAAAGACAGTCGTCAAAAGCATCATTATAGTTATGAAGTTACATTTGATAATGGCAAAGCTTTGAAATATGTTCAGGAAAAAGACTTAGTTAAAACAAAAAGATCTAAATACAGCAAAGGTCAAATTGTCAAATTAAAATCCTCTGCGACAGCTGATTTAGATGGCAGCAGTTTAACGGATTATCGTGCATCAGCTGGTAAAATCGATCATATTTCTTATAATCATAGCAATACCACAGGTGGCTATAAGTATGATATCACCTTTGATGAAGGCGGCAAGGTGACTAATATTCAAGAAAAAGATTTGGATAAGGTTTATGAAGTTCAGCTAAAATCAGAAAATACTGCAGCTCAAAATAATGAGATTCTTAAACAAGCTTTTGCATATGCTAAACAACATTCTGGTACTATCTTAAGTTTGCCAAACGGTGAATTTAAGATTGGCAGTCAGACACCAGACAAGGATTATATCACTTTAACATCTGATACTGAAATTCGTGGAGATAATACGACACTTTTGGTTGAAGGATCGGCTTATTGGTTTGCTTTTGCAACTGGGACATCAGCTAGTGATGGTGTAAAGAATTTCACCATGCGCAATATCAATATAAAAGCCAGTGATTTGGAAAAAGGAAATCAGTTTATGATTATGGCTGATCATGGTGATAATTGGAAAATTTGTAACAATAGTTTTACCATGGTGCATAAAAAAGGAAGCCACATTTTTGACTTAGGTTCCTTGCAAAATTCAGCTTTTGAAGGAAATCAATTTACTGGCTATGCCCCTGAATTAACTAATGTCAGTAAGATTGATGATAATGCAGATCTTCATGATTTTTATTCAGAAGTTATCCAGCTGGATGCCGCTGAGTCTAGCGGTGTTTGGGATGGTGGGTTGATAAAGGCTATTGATCCAAATTATGAAAATTATAATAAAGAGAAACAGTTGTGCAATAACATCACGATTGCTAATAACTCTTTTGTTCCTTATATAGACAGTCATGGTAAAATAATAGCATACAGCGGAACTATCGGACAGCACTCTTCTGATGTCGGCCTTGTCAAAATTTATGATAATGTTTTTAGTAACTCTTTGGTCAGCCGTTTCAATCAAAATGGCAAAAGCGAGGCGTGGATTTTTAAAGCTATTCACCTAAAATCAAATTATAATAATGCTGTTTATGCCAATTCTATCAGTTAA","9.80","13.29","56346","MKSRKRQRKGLVRKNEIIILTLFVASAVSLLAFTNSFGVLAKSLHLEKINKSITISLPFGKKKMEQTARYYSGEQVQISSSAKKDSLGKGLSHYQNWIGTVKKIKSQKDSRQKHHYSYEVTFDNGKALKYVQEKDLVKTKRSKYSKGQIVKLKSSATADLDGSSLTDYRASAGKIDHISYNHSNTTGGYKYDITFDEGGKVTNIQEKDLDKVYEVQLKSENTAAQNNEILKQAFAYAKQHSGTILSLPNGEFKIGSQTPDKDYITLTSDTEIRGDNTTLLVEGSAYWFAFATGTSASDGVKNFTMRNINIKASDLEKGNQFMIMADHGDNWKICNNSFTMVHKKGSHIFDLGSLQNSAFEGNQFTGYAPELTNVSKIDDNADLHDFYSEVIQLDAAESSGVWDGGLIKAIDPNYENYNKEKQLCNNITIANNSFVPYIDSHGKIIAYSGTIGQHSSDVGLVKIYDNVFSNSLVSRFNQNGKSEAWIFKAIHLKSNYNNAVYANSIS","765618","","conserved hypothetical protein","Extracellular","Matches in gapped BLAST to hypothetical protein: residues 4-506 are 80% similar to the protein in S.pyogenes (gi|15675168|). Residues 304-474 are 29% similar to the protein in Lactococcus lactis (gi|15672905|). SMu0744 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR011050
Domain

Pectin lyase fold/virulence factor
SSF51126	$\"[230-505]T$	Pectin_lyas_like

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 304-474 are 29% similar to a (PROTEOME COMPLETE) protein domain (PD401614) which is seen in Q9CH18_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 09:09:01 2002","Thu Dec 20 08:25:11 2001","Wed Mar 20 09:09:01 2002","Thu Dec 20 08:25:11 2001","","Thu Dec 20 08:25:11 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0744 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 12:53:03 2002","","No significant hits to the NCBI PDB database.","SMU.820","","No significant hits to the Pfam 11.0 database","Thu Dec 20 08:25:11 2001","24379275","","","","","","1","","","SMU.820","" "SMu0745","765772","767550","1779","CTGGTTGTTGATAAAGAGAAGATTAAAGAAATCAAAGACAGTATCAACATTGTTGATGTTATTGGTGAAGTTGTTAGTCTTTCACGCTCTGGTCGTAATTATTTAGGACTTTGTCCTTTTCACAAAGAAAAGACCCCTTCTTTTAATGTTATTGAAGATCGTCAATTTTTTCATTGCTTTGGTTGCGGCCGCTCAGGAGATGTTTTTAAATTTGTTGAGGATTATCGTAACATTAGCTTTCTGGAAAGCGTTCAGGTTTTAGCTGAGCGTTCAGGTATTAATGTTACTCTTCAAGATAAGAGTCAAGAAGTTAAAAAGGAACATCCACATCAAAAACTTTTTAATATCAATGGAGATGCGAACAAATTCTATCAAGCTGTTTTGAAGACAACGAAAGTTGGAGAAACTGCACGGCAGTATCTTTATGAGAGAGGTTTGACAGATGAACTTATCACTTATTTTAAGATAGGTTTGGCTCCCAATGAGTATGATTATCTGTATCAGGCCATGCTCAAAAAATATGATGAAGATACAATTATTAATTCAGGTTTGTTTAATCTATCAGATAGCAATTCCATTTATGATGCTTTTCGTAATCGGATCATGTTTCCTTTGACTGATGAATTTGGACACATTATAGGTTTTTCGGGACGGATTTGGACAGAAGAAGATACTTCTAAAAAATTAGCAAAGTATAAGAATACCCGCTCAACAATCATTTTTAATAAATCTTACGAACTTTACCATTTGGATAAGGCTAGGACTGCAGCTAAAAAAGAACATGAACTTTATCTTATGGAAGGCTTTATGGATGTTATTGCAGCCTATCGTGCGGGTATTCCTAATGCTGTTGCTTCTATGGGGACAGCGCTAACACCAGAACATGTTAAGCATTTAAGAAAATTTACTAAAAAAGTTATTTTGACCTATGATGGTGATAAAGCCGGACAAAATGCTATTGCTAAATCATTGAACTTGCTGTCTAATATGGCGGTGGAAATTGTTAGAATTCCCGGACAGATGGATCCAGATGAATTTATCAAGGAGAATTCAGAAGAGGAATTAGAAAAGCTGCTAAAACAAGCAAGGATTAGCAGTGCTGAGTTTTGGATTGAACATCTAAAACCTGAAAATATTGATAATTTGCAAGCGGAAATTGACTATGTCGAAAAGATAGCTAAGGTTATTGCTGCTTCACCGTCTATAACAGCTCAGAATACCTATATTAATAAAGTAGCTGAGTTTCTACCAGATTTTGATTATTTACAGGTTGAACAGGCAGTTAATAATGAGCGACTGCAAATGCGTTCACAAATCAGCGAACAAGAGTCAGCCAATCAGCAGGTTTTAATAGATTTGCCGGTAACTAAACAATTAACCGCTTTAACTAAAGCCGAGAGTCAATTATTCCACCGCTTACTCCACCACGATTACCTCTTGAATGAATTTCGTAATCGTGCTCATTTTAAATTTACAACGCCAGAATTACAAGAACTTTATCAAATTCTCAAAACTAACGGTGAGATTAATGCTTATGATTTGTCTCAACTTTCCAATCAGCTTCAGGAAACTTATTATCGTGTTTTAGAAGAAAATCTTCCTGAAGAAATTGCTGAAGATGAAATTAGGCAGATTGAAGATCAAATTGATAAGTGTTTGCAGCGACAAGAAATGCGCAAACAAAGCAAAGCTATTCGAGAGAGTAGCAATCATGGTGATGTAGATACTGCAGTGGAGGGATTAGCAGCCCTGATCGCTCAAAAAAGAAATATGGAATAG","5.50","-13.50","68101","MVVDKEKIKEIKDSINIVDVIGEVVSLSRSGRNYLGLCPFHKEKTPSFNVIEDRQFFHCFGCGRSGDVFKFVEDYRNISFLESVQVLAERSGINVTLQDKSQEVKKEHPHQKLFNINGDANKFYQAVLKTTKVGETARQYLYERGLTDELITYFKIGLAPNEYDYLYQAMLKKYDEDTIINSGLFNLSDSNSIYDAFRNRIMFPLTDEFGHIIGFSGRIWTEEDTSKKLAKYKNTRSTIIFNKSYELYHLDKARTAAKKEHELYLMEGFMDVIAAYRAGIPNAVASMGTALTPEHVKHLRKFTKKVILTYDGDKAGQNAIAKSLNLLSNMAVEIVRIPGQMDPDEFIKENSEEELEKLLKQARISSAEFWIEHLKPENIDNLQAEIDYVEKIAKVIAASPSITAQNTYINKVAEFLPDFDYLQVEQAVNNERLQMRSQISEQESANQQVLIDLPVTKQLTALTKAESQLFHRLLHHDYLLNEFRNRAHFKFTTPELQELYQILKTNGEINAYDLSQLSNQLQETYYRVLEENLPEEIAEDEIRQIEDQIDKCLQRQEMRKQSKAIRESSNHGDVDTAVEGLAALIAQKRNME","767549","For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0074(dnaK);SMu075 (dnaJ); SMu1091 (dnaE); SMu1745 (dnaI); SMu1746(dnaB);SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC). DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis [gi:1709769].","DNA primase","Cytoplasm","Several matches in gapped BLAST to DNA primase: residues 13-591 are 61% similar to the protein in S.pyogenes (gi|15674826|). Residues 15-591 are 51% similar to the protein from S.pneumoniae(gi|15900941|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1427 (0.0).","

InterPro
IPR002694
Domain

Zinc finger, CHC2-type
PD002988	$\"[13-86]T$	Q8DUS6_STRMU_Q8DUS6;
PF01807	$\"[2-99]T$	zf-CHC2
SM00400	$\"[33-87]T$	ZnF_CHCC

InterPro
IPR006154
Domain

Toprim subdomain
SM00493	$\"[260-331]T$	TOPRIM

InterPro
IPR006171
Domain

TOPRIM
PF01751	$\"[260-337]T$	Toprim

InterPro
IPR006295
Domain

DNA primase
TIGR01391	$\"[1-415]T$	dnaG: DNA primase

InterPro
IPR006647
Domain

Toprim, primase
PD002276	$\"[120-346]T$	Q8DUS6_STRMU_Q8DUS6;

InterPro
IPR010916
Domain

TonB box, N-terminal
PS00430	$\"[1-88]?$	TONB_DEPENDENT_REC_1

InterPro
IPR013173
Domain

DNA primase DnaG, DnaB-binding
SM00766	$\"[464-584]T$	no description

InterPro
IPR013237
Domain

Phage P4 alpha, zinc-binding
SM00778	$\"[32-68]T$	no description

InterPro
IPR013264
Domain

DNA primase catalytic core, N-terminal
G3DSA:3.90.980.10	$\"[111-241]T$	no description
PF08275	$\"[123-253]T$	Toprim_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.1360.10	$\"[242-363]T$	no description
G3DSA:3.90.580.10	$\"[2-100]T$	no description

","BeTs to 15 clades of COG0358COG name: DNA primase (bacterial type)Functional Class: LThe phylogenetic pattern of COG0358 is amtk-qvcebrhujGPolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002694 (CHC2 zinc finger) with a combined E-value of 1.4e-100. IPB002694A 37-82 IPB002694B 139-159 IPB002694C 193-217 IPB002694D 229-248 IPB002694E 263-300 IPB002694F 302-315 IPB002694G 336-346","Residues 212-345 are 61% similar to a (DNA PRIMASE 2.7.7.- TRANSFERASE) protein domain (PD002276) which is seen in Q9CI14_LACLA.Residues 93-172 are 38% similar to a (DNA PRIMASE REPLICATION METAL-BINDING) protein domain (PD003861) which is seen in Q9KD44_BACHD.Residues 109-209 are 28% similar to a (DNA TRANSFERASE POLYMERASE PRIMASE) protein domain (PD290405) which is seen in PRIM_CLOAB.Residues 367-590 are 25% similar to a (DNA PRIMASE 2.7.7.- TRANSFERASE) protein domain (PD119307) which is seen in Q9CI14_LACLA.Residues 94-161 are 47% similar to a (DNA 2.7.7.- PRIMASE METAL-BINDING) protein domain (PD203954) which is seen in Q9CI14_LACLA.Residues 33-88 are 57% similar to a (DNA PRIMASE 2.7.7.- TRANSFERASE) protein domain (PD002988) which is seen in Q9CI14_LACLA.Residues 163-210 are 47% similar to a (DNA PRIMASE 2.7.7.- TRANSFERASE) protein domain (PD410978) which is seen in Q9CI14_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:42:59 2002","Thu Dec 20 08:26:58 2001","Thu Mar 28 10:23:26 2002","Thu Dec 20 08:26:58 2001","Thu Dec 20 08:26:58 2001","Thu Dec 20 08:26:58 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0745 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 08:29:23 2001","Thu Dec 20 08:26:58 2001","pdb|1DD9|A Chain A, Structure Of The Dnag Catalytic Core >gi|77... 152 1e-037pdb|1EQN|A Chain A, E.Coli Primase Catalytic Core >gi|9256899|p... 144 2e-035pdb|1D0Q|A Chain A, Structure Of The Zinc-Binding Domain Of Bac... 106 6e-024","SMU.821","","Residues 2 to 99 (E-value = 9.5e-49) place SMu0745 in the zf-CHC2 family which is described as CHC2 zinc finger (PF01807)Residues 260 to 337 (E-value = 8.4e-18) place SMu0745 in the Toprim family which is described as Toprim domain (PF01751)","Thu Dec 20 08:26:58 2001","24379276","","","Araya-Kojima,T., Ishibashi,N., Shimamura,S., Tanaka,K. andTakahashi,H.Identification and molecular analysis of Lactococcus lactis rpoDoperonBiosci. Biotechnol. Biochem. 59 (1), 73-77 (1995)PubMed: 7765979Versalovic,J. and Lupski,J.R.The Haemophilus influenzae dnaG sequence and conserved bacterialprimase motifsGene 136 (1-2), 281-286 (1993)PubMed: 8294018Versalovic,J., Koeuth,T., Britton,R., Geszvain,K. and Lupski,J.R.Conservation and evolution of the rpsU-dnaG-rpoD macromolecularsynthesis operon in bacteriaMol. Microbiol. 8 (2), 343-355 (1993)PubMed: 8316085","","Mon Jan 14 08:30:52 2002","1","","","SMU.821","151" "SMu0746","767558","768673","1116","ATGGTAAATAATAAGAAAAAAACATCAAGTACTTTTAATGTTCAAGTTGCAGATTTTATTCGCAACCATAAAAAAGAGGGAGTTGCTGTTGATGATGAAGTTACTGAAAAATTAGTTATCCCTTTTGAACTTGAAGCAGAGCAGATTGATGATTTGCTGGAACGTTTGACAGATGGCGGTATCTCAATTACTGACAGAGAAGGCAATCCTTCTACCAAATATGCTGTTGAAGAAATTAAACCAGAAGAATTAACCGATGAAGAATTATTAGGCAGTAATTCTGCCAAGGTTAATGATCCTGTTCGCATGTATTTAAAAGAGATTGGCGTTGTTCCTCTTTTGACTAATGAAGAAGAAAAAGAACTAGCTATTGCTGTTGAAAATGGCGATCTTGAAGCGAAGCAGCGCTTGGCAGAAGCTAATTTACGTTTGGTTGTTTCCATTGCAAAACGATACGTAGGACGCGGAATGCAGTTTCTTGATCTCATTCAAGAAGGTAATATGGGTTTGATGAAGGCAGTTGATAAATTTGATTATTCCAAAGGTTTCAAGTTTTCAACCTATGCAACTTGGTGGATTCGTCAGGCAATCACACGTGCCATTGCAGACCAAGCACGTACGATTCGTATTCCAGTACATATGGTGGAAACGATCAATAAGCTGGTGCGTGAGCAGCGCAATCTTCTTCAAGAGCTGGGGCAAGATCCAACACCGGAGCAAATTGCTGAGCGAATGGATATGACACCAGATAAAGTGCGTGAAATTTTAAAAATTGCTCAAGAACCGGTGTCTCTTGAAACACCAATTGGTGAAGAAGATGACAGCCATTTAGGCGATTTTATTGAAGATGAAGTCATCGAAAATCCCGTTGATTATACAACTCGTGTTGTCTTGCGTGAGCAGTTAGATGAAGTTTTGGATACTCTTACTGATCGTGAAGAAAATGTCCTTCGTCTGCGTTTCGGGCTTGATGATGGAAAAATGCGGACGCTTGAAGATGTTGGTAAAGTCTTTGATGTTACTCGTGAACGTATTCGTCAAATTGAGGCTAAAGCGCTTCGCAAGCTGCGTCACCCTAGTCGCAGCAAGCAGTTACGTGATTTTGTTGAAGATTAA","4.70","-19.97","42535","MVNNKKKTSSTFNVQVADFIRNHKKEGVAVDDEVTEKLVIPFELEAEQIDDLLERLTDGGISITDREGNPSTKYAVEEIKPEELTDEELLGSNSAKVNDPVRMYLKEIGVVPLLTNEEEKELAIAVENGDLEAKQRLAEANLRLVVSIAKRYVGRGMQFLDLIQEGNMGLMKAVDKFDYSKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLVREQRNLLQELGQDPTPEQIAERMDMTPDKVREILKIAQEPVSLETPIGEEDDSHLGDFIEDEVIENPVDYTTRVVLREQLDEVLDTLTDREENVLRLRFGLDDGKMRTLEDVGKVFDVTRERIRQIEAKALRKLRHPSRSKQLRDFVED","768672","For other 'rpo' genes see, SMu0086 (rpoE); Smu1817 (rpoA); Smu1807 (rpoB); SMu1806 (rpoC) and SMu0433 (rpoZ).From Genbank:[gi:3914824]The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.This is the primary sigma-factor of this bacteria.","RNA polymerase sigma-70 factor","Cytoplasm","Matches in gapped BLAST to sigma 42 protein: residues 1-371 are100% similar to the previously published protein in S.mutans (gi2258087).Residues 5-371 are 93% similar to the protein in S.pyogenes (gi15674827) and are 87% similar to the protein in S.pneumoniae (gi15900942).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1426 (0.0).","

InterPro
IPR000943
Domain

RNA polymerase, Sigma-70 factor
PR00046	$\"[161-174]T$ $\"[185-193]T$ $\"[309-321]T$ $\"[330-345]T$ $\"[345-356]T$	SIGMA70FCT
PS00715	$\"[161-174]T$	SIGMA70_1
PS00716	$\"[330-356]T$	SIGMA70_2

InterPro
IPR007624
Domain

RNA polymerase sigma-70 region 3
PF04539	$\"[211-293]T$	Sigma70_r3

InterPro
IPR007627
Domain

RNA polymerase sigma-70 region 2
PF04542	$\"[137-207]T$	Sigma70_r2

InterPro
IPR007630
Domain

RNA polymerase sigma-70 region 4
PF04545	$\"[305-358]T$	Sigma70_r4

InterPro
IPR009042
Domain

RNA polymerase, Sigma-70 region 1.2
PF00140	$\"[98-134]T$	Sigma70_r1_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[210-261]T$ $\"[291-369]T$	Wing_hlx_DNA_bd

InterPro
IPR012760
Domain

RNA polymerase sigma factor RpoD, C-terminal
TIGR02393	$\"[133-370]T$	RpoD_Cterm

InterPro
IPR013325
Domain

RNA polymerase sigma factor, region 2
SSF88946	$\"[37-204]T$	Sigma_r2

InterPro
IPR014284
Domain

RNA polymerase sigma-70
TIGR02937	$\"[132-360]T$	sigma70-ECF

noIPR
unintegrated

unintegrated
G3DSA:1.10.601.10	$\"[37-206]T$	G3DSA:1.10.601.10

","BeTs to 12 clades of COG0568COG name: DNA-dependent RNA polymerase sigma subunits (sigma70/32)Functional Class: KThe phylogenetic pattern of COG0568 is -----QvCEBRHujgpOLinXNumber of proteins in this genome belonging to this COG is 1","***** IPB000943 (Sigma-70 factor family) with a combined E-value of 3.1e-43. IPB000943 150-201","Residues 216-270 are 47% similar to a (FACTOR POLYMERASE RNA SIGMA) protein domain (PD341022) which is seen in Q9PQE2_UREPA.Residues 272-369 are identical to a (FACTOR RNA POLYMERASE SIGMA REGULATION DNA-BINDING) protein domain (PD340420) which is seen in O33662_STRMU.Residues 72-132 are identical to a (FACTOR SIGMA RNA POLYMERASE TRANSCRIPTION DNA-BINDING) protein domain (PD003138) which is seen in O33662_STRMU.Residues 282-357 are 31% similar to a (FACTOR POLYMERASE RNA SIGMA SPORULATION DNA-BINDING) protein domain (PD002854) which is seen in Q9K9T9_BACHD.Residues 5-69 are identical to a (SIGMA POLYMERASE FACTOR RNA) protein domain (PD353407) which is seen in O33662_STRMU.Residues 153-356 are 23% similar to a (FACTOR INITIATION SIGMA MITOCHONDRION) protein domain (PD086592) which is seen in O21282_RECAM.Residues 279-361 are 40% similar to a (FACTOR RNA POLYMERASE SIGMA) protein domain (PD327956) which is seen in P95657_RHOSH.Residues 218-270 are identical to a (FACTOR SIGMA RNA POLYMERASE REGULATION DNA-BINDING) protein domain (PD000301) which is seen in O33662_STRMU.Residues 217-270 are 40% similar to a (SIGMA POLYMERASE FACTOR RNA) protein domain (PD384885) which is seen in RPSD_MYCGE.Residues 178-216 are 94% similar to a (FACTOR POLYMERASE RNA SIGMA REGULATION DNA-DIRECTED) protein domain (PD000270) which is seen in P95644_RENSA.Residues 133-177 are identical to a (FACTOR POLYMERASE RNA SIGMA TRANSCRIPTION REGULATION) protein domain (PD000245) which is seen in O33662_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 10 10:45:58 2006","Thu Aug 10 10:45:58 2006","Thu Aug 10 10:45:58 2006","Thu Dec 20 08:39:41 2001","Thu Dec 20 08:39:41 2001","Thu Dec 20 08:39:41 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0746 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 08:40:48 2001","Thu Aug 10 10:45:58 2006","pdb1SIG Crystal Structure Of A Sigma70 Subunit Fragment Fr... 131 1e-031","SMU.822","","Residues 98 to 134 (E-value = 8.5e-17) place SMu0746 in the Sigma70_r1_2 family which is described as Sigma-70 factor, region 1.2 (PF00140)Residues 137 to 207 (E-value = 9.2e-30) place SMu0746 in the Sigma70_r2 family which is described as Sigma-70 region 2 (PF04542)Residues 211 to 293 (E-value = 1.7e-41) place SMu0746 in the Sigma70_r3 family which is described as Sigma-70 region 3 (PF04539)Residues 305 to 358 (E-value = 3.5e-24) place SMu0746 in the Sigma70_r4 family which is described as Sigma-70, region 4 (PF04545)","Thu Aug 10 10:45:58 2006","24379277","","Tsukioka,Y., Yamashita,Y., Nakano,Y., Oho,T. and Koga,T.Identification of a fourth gene involved in dTDP-rhamnose synthesis in Streptococcus mutansJ. Bacteriol. 179 (13), 4411-4414 (1997)PubMed: 9209063","Grebe,T., Paik,J. and Hakenbeck,R.A novel resistance mechanism against beta-lactams in Streptococcuspneumoniae involves CpoA, a putative glycosyltransferaseJ. Bacteriol. 179 (10), 3342-3349 (1997)PubMed: 9150233Frere,J., Gansel,X., Benachour,A. and Auffray,Y.Molecular analysis of the rpoD gene of Enterococcus faecalisJ. Basic Microbiol. 36 (5), 305-310 (1996)PubMed: 8914262Araya,T., Ishibashi,N., Shimamura,S., Tanaka,K. and Takahashi,H.Genetic and molecular analysis of the rpoD gene from LactococcuslactisBiosci. Biotechnol. Biochem. 57 (1), 88-92 (1993)PubMed: 7503808Gitt,M.A., Wang,L.F. and Doi,R.H.A strong sequence homology exists between the major RNA polymerasesigma factors of Bacillus subtilis and Escherichia coliJ. Biol. Chem. 260 (12), 7178-7185 (1985)PubMed: 2987246Wang,L.F. and Doi,R.H.Nucleotide sequence and organization of Bacillus subtilis RNApolymerase major sigma (sigma 43) operonNucleic Acids Res. 14 (10), 4293-4307 (1986)PubMed: 3086839","Thu Jan 24 12:59:29 2002","Thu Dec 20 08:58:02 2001","1","","","SMU.822","150" "SMu0747","768686","769021","336","ATGGCAGATAAAAACTATACTCCCGAAGAAATTGCTAAAATTAAAGATAGAATCCTTGAAGCTTTGGAAATGGTTATTGATCCAGAATTGGGTATTGATATTGTTAATCTAGGTCTTATCTATGATATTCGTTTTGAAGATTCAGGCCGTACTGAAATTGATATGACATTAACAACGATGGGCTGCCCATTAGCAGATTTGCTTACAGATCAAATCCACGATGCTCTTAAAGACGTTCCAGAAGTTTTGGACATTGATGTGAAACTTGTTTGGTCACCAGCTTGGACAGTGGATAAAATGAGCCGCTATGCCCGTATTGCGTTAGGGATTCGTTGA","4.20","-9.81","12558","MADKNYTPEEIAKIKDRILEALEMVIDPELGIDIVNLGLIYDIRFEDSGRTEIDMTLTTMGCPLADLLTDQIHDALKDVPEVLDIDVKLVWSPAWTVDKMSRYARIALGIR","769020","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical protein : residues 1-111 are 100% similar to an unnamed protein product in S.mutans (gi|2258088|).Residues 6-111 are 81% similar to a conserved hypothetical protein from S.pyogenes (gi|15674828|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1425 (1e-50).","

InterPro
IPR002744
Domain

Protein of unknown function DUF59
PD005595	$\"[15-95]T$	DUF59
PF01883	$\"[14-89]T$	DUF59

","BeTs to 7 clades of COG2151COG name: Putative aromatic ring hydroxylating enzymeFunctional Class: RThe phylogenetic pattern of COG2151 is -mtk--v-ebr----------Number of proteins in this genome belonging to this COG is 2","***** IPB002744 (Domain of unknown function DUF59) with a combined E-value of 3.7e-21. IPB002744A 20-30 IPB002744B 58-87","Residues 15-87 are identical to a (COMPLETE PROTEOME ATP-BINDING HOMOLOG) protein domain (PD005595) which is seen in O33663_STRMU.Residues 90-111 are identical to a (COMPLETE PROTEOME DTDP-4-KETO-L-RHAMNOSE) protein domain (PD222130) which is seen in O33663_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 09:37:47 2002","Thu Dec 20 09:05:03 2001","Wed Mar 20 09:37:47 2002","Thu Dec 20 09:05:03 2001","Thu Dec 20 09:05:03 2001","Thu Dec 20 09:05:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0747 is paralogously related (blast p-value < 1e-3) to SMu1932, a predicted conserved hypothetical protein.","Thu Jan 24 13:00:42 2002","","No significant hits to the NCBI PDB database.","SMU.823","","Residues 14 to 89 (E-value = 8.4e-36) place SMu0747 in the DUF59 family which is described as Domain of unknown function DUF59 (PF01883)","Thu Dec 20 09:05:03 2001","24379278","","Tsukioka Y, Yamashita Y, Nakano Y, Oho T, Koga TIdentification of a fourth gene involved in dTDP-rhamnose synthesis in Streptococcus mutans.J Bacteriol 1997 Jul;179(13):4411-4 PubMed: 9209063PMID: 9209063","","Tue Mar 26 09:50:30 2002","","1","","","SMU.823","831" "SMu0748","769338","770192","855","ATGATTTTAATCACAGGAAGTAATGGTCAATTAGGTACAGAATTACGTCATTTACTTGATGAACGTAATGAAGACTATGTGGCTGTTGATGTTGCAGAGATGGATATTACAAAAGCTGAAAAAGTGGATGAAGTCTTTTTACAGGTTAAACCGAGTCTTGTCTACCATTGTGCAGCCTATACAGCAGTTGATGCTGCAGAAGATGAAGGTAAAGAGTTGGATTATGCTATCAATGTGACAGGAACTGAAAACATTGCTAAGGCTTGTGAGAAATATAATGCAACTTTGGTTTACATTTCAACTGATTATGTGTTTGATGGTGAAAAGCCAGTTGGTCAAGAATGGGAAGTGGATGATAAGCCAGATCCTAAGACTGAGTATGGTCGGACAAAGCGTTTAGGTGAAGAAGCAGTTGAAAAATACGTTAAGAACTTTTACATCATCCGTACAGCTTGGGTATTTGGTAATTATGGTAAAAATTTTGTTTTTACTATGCAACATCTTGCTAAAAGTCATAACAGTTTAACGGTTGTTAATGATCAGCATGGTCGTCCGACTTGGACACGAACTTTAGCTGAATTTATGACTTATCTGGCTGAAAATCAAAAAGAATATGGTTACTATCATTTATCAAATGATGCAACTGAGGATACGACTTGGTATGATTTTGCACTTGAAATTTTAAAGGATACCGATGTTGTCGTAAAACCTGTTGACTCTAGTCAGTTCCCTGCTAAAGCCAAACGGCCGTTAAATTCAACTATGAGTTTGACAAAGGCTAAGGCGACAGGATTTGTTATTCCGACTTGGCAAGAAGCTTTACAAGAATTTTATAAGCAGGATGTCAAAAAATAG","4.80","-12.62","32398","MILITGSNGQLGTELRHLLDERNEDYVAVDVAEMDITKAEKVDEVFLQVKPSLVYHCAAYTAVDAAEDEGKELDYAINVTGTENIAKACEKYNATLVYISTDYVFDGEKPVGQEWEVDDKPDPKTEYGRTKRLGEEAVEKYVKNFYIIRTAWVFGNYGKNFVFTMQHLAKSHNSLTVVNDQHGRPTWTRTLAEFMTYLAENQKEYGYYHLSNDATEDTTWYDFALEILKDTDVVVKPVDSSQFPAKAKRPLNSTMSLTKAKATGFVIPTWQEALQEFYKQDVKK","770191","For other 'rml' genes see SMu1330 (rmlA); SMu1327 (rmlB) and SMu1329 (rmlC).","dTDP-4-keto-L-rhamnose reductase","Cytoplasm","Matches in gapped BLAST to dTDP-4-keto-L-rhamnose reductase :residues 1-284 are 99% similar to the previously published enzyme in S.mutans (gi2258089). Residues 1-283 are 87% similar to the protein from S.pneumoniae (gi2804692).Residues 1-284 are 82% similar to the protein from S.pyogenes (gi15674829).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1424 (1e-148).","

InterPro
IPR005913
Family

dTDP-4-dehydrorhamnose reductase
PF04321	$\"[1-283]T$	RmlD_sub_bind
TIGR01214	$\"[1-281]T$	rmlD

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[2-212]T$	G3DSA:3.40.50.720
PTHR10491	$\"[1-283]T$	PTHR10491
SSF51735	$\"[1-284]T$	SSF51735

","BeTs to 8 clades of COG1091COG name: dTDP-4-dehydrorhamnose reductaseFunctional Class: MThe phylogenetic pattern of COG1091 is --tk-q-cebr---------xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 2-69 are 44% similar to a (PROTEOME COMPLETE DTDP-4-DEHYDRORHAMNOSE) protein domain (PD350385) which is seen in Q9JV74_NEIMA.Residues 2-243 are 25% similar to a (PROTEOME COMPLETE REDUCTASE) protein domain (PD239065) which is seen in Q9S4H1_LEPIN.Residues 233-284 are identical to a (SYNTHASE DTDP-L-RHAMNOSE REDUCTASE) protein domain (PD267408) which is seen in O33664_STRMU.Residues 194-232 are 92% similar to a (SYNTHASE DTDP-L-RHAMNOSE CPS19AO COMPLETE) protein domain (PD393546) which is seen in O54665_STRPN.Residues 149-193 are 88% similar to a (SYNTHASE DTDP-L-RHAMNOSE PROTEOME) protein domain (PD310301) which is seen in Q9R918_STRPN.Residues 2-229 are 99% similar to a (COMPLETE PROTEOME 4-EPIMERASE REDUCTASE UDP-GLUCOSE NAD) protein domain (PD000038) which is seen in O33664_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 13:57:18 2006","Thu Dec 20 09:06:17 2001","Thu Sep 14 13:57:18 2006","Thu Dec 20 09:06:17 2001","","Thu Dec 20 09:06:17 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0748 is paralogously related (blast p-value < 1e-3) to SMu1327,a predicted dTDP-glucose-4,6-dehydratase and SMu0346,a predicted UDP-glucose 4-epimerase.","Tue Jan 15 13:09:53 2002","","No significant hits to the NCBI PDB database.","SMU.824","","Residues 2 to 275 (E-value = 3.3e-05) place SMu0748 in the Epimerase family which is described as NAD dependent epimerase/dehydratase family (PF01370)Residues 142 to 274 (E-value = 2.2e-62) place SMu0748 in the RmlD_sub_bind family which is described as RmlD substrate binding domain (PF04321)","Thu Sep 14 13:57:18 2006","24379279","","Tsukioka,Y., Yamashita,Y., Nakano,Y., Oho,T. and Koga,T.Identification of a fourth gene involved in dTDP-rhamnose synthesis in Streptococcus mutansJ. Bacteriol. 179 (13), 4411-4414 (1997)PubMed: 9209063","Kneidinger,B., Graninger,M.,Puchberger,M., Kosma,P. and Messner,P.Biosynthesis of nucleotide-activated D-glycero-D-manno-heptoseJ. Biol. Chem. 276 (24), 20935-20944 (2001)PubMed: 11279237Jiang,S.M., Wang,L. and Reeves,P.R.Molecular characterization of Streptococcus pneumoniae type 4, 6B,8, and 18C capsular polysaccharide gene clustersInfect. Immun. 69 (3), 1244-1255 (2001)PubMed: 11179285PUBMED 11179285","Tue Mar 26 09:51:38 2002","Tue Jan 15 13:06:43 2002","1","","","SMU.824","421" "SMu0749","770365","771453","1089","GTGGAAGAATTGGTTAAGCATAAACAGTCGCAGCAGTTAACTTATCATGTGGCCTGTCTTAGTGAGACTGACCAGCATAAGCATTTTACCTATTTAGGTGTTGATTGTTTTACTATTAAGGCTCCTAAGCTGGGTCCTGCCAGAGTCATTGCTTATGATATGATGGCTATTCGCTATGCTTTAAAGTTGATCAAGGATCAAAAAATCAAACACCCTATTTTTTATATTTTAGGAAATACAATCGGTGCTTTTATGGGACCCTTTGCTCGTAAGATTAAGCGCATAGGCGGACGATTTTATATTAATCCAGATGGTTTGGAATGGCGACGTTCTAAATGGTCACGTCCAGTGCAAGCCTATCTTAAATATGCTGAAAAATGCATGACCAAAAAAGCTGATTTGGTTATTTCTGATAATACTGGAATTGAAGGCTATATCAAACAAATGTATCCTTGGGCAAAGACGACTTTTATTGCCTATGGCACGGATTTATCACCTTCAGGGCTGTCAAAAAACGATTCCAAGGTTAAAGACTTTTATAAAAAATGGGCTATTAAAGATAAAGGATACTATCTCATTGTTGGACGTTTTGTTCCTGAGAATAACTATGAAACAGCTATCCGTGAATTCATGACTTCGTCAAGTGAACGTGATTTGGTTATTATTTGCAATTATGAAGGCAATGCCTATTTTGAAGATTTGCGACAAAAAACCGAATTTGATAAAGATAAGCGTATTAAATTTGTTGGGACAGTTTATGATCGTCCTCTTTTAACTTATATTCGTGAACAAGCTTTTGCTTATATTCACGGTCACGAGGTTGGAGGGACTAATCCCGGTTTGCTTGAAGCTTTAGCCCATACGGACTTGAATCTTGTCTTGATTACTGAATTTAATTATACAGTAGCATTAGATGCTGCACGGTATTGGACTCAGGATAGTGGAAGTCTTGCTCAGTTAATCAATCAATTTGATAAACAGGAAAATTTTGCAGAGTATGGACAAAGAGCTAAGGAAATTATTGTAAATTACTATACTTGGGAGAAAATTGTAGAAGAGTACGAGGACTTGTTCTTACATGAAAGTTAA","8.50","5.00","42076","MEELVKHKQSQQLTYHVACLSETDQHKHFTYLGVDCFTIKAPKLGPARVIAYDMMAIRYALKLIKDQKIKHPIFYILGNTIGAFMGPFARKIKRIGGRFYINPDGLEWRRSKWSRPVQAYLKYAEKCMTKKADLVISDNTGIEGYIKQMYPWAKTTFIAYGTDLSPSGLSKNDSKVKDFYKKWAIKDKGYYLIVGRFVPENNYETAIREFMTSSSERDLVIICNYEGNAYFEDLRQKTEFDKDKRIKFVGTVYDRPLLTYIREQAFAYIHGHEVGGTNPGLLEALAHTDLNLVLITEFNYTVALDAARYWTQDSGSLAQLINQFDKQENFAEYGQRAKEIIVNYYTWEKIVEEYEDLFLHES","771452","For other 'rgp' genes see SMu0750 (rgpBc);SMu0751 (rgpCc); SMu0752 (rgpDc); SMu0753 (rgpEc) and SMu0754 (rgpFc).note=\"involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans\"","polysaccharide biosynthesis protein; rhamnosyl transferase","Cytoplasm","Matches in gapped BLAST to rgpAc protein: residues 1-362 are98% similar to the protein in S.mutans (gi7474177).Residues 1-361 are 66% similar to the protein from S.pyogenes (gi15674830).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1423 (1e-143).","

InterPro
IPR015393
Domain

Protein of unknown function DUF1972
PF09314	$\"[1-163]T$	DUF1972

noIPR
unintegrated

unintegrated
PTHR12526	$\"[95-361]T$	GLYCOSYLTRANSFERASE
PTHR12526:SF3	$\"[95-361]T$	GLYCOSYLTRANSFERASE

","BeTs to 5 clades of COG0438COG name: Glycosyltransferases IFunctional Class: MThe phylogenetic pattern of COG0438 is AMTKYQVCEBRhUj--o---XNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 1-176 are 45% similar to a (TRANSFERASE PROTEOME COMPLETE) protein domain (PD191605) which is seen in Q9ZII4_STRPN.Residues 189-358 are 99% similar to a (TRANSFERASE PROTEOME COMPLETE) protein domain (PD152547) which is seen in O82873_STRMU.Residues 1-177 are 98% similar to a (PROTEOME TRANSFERASE COMPLETE) protein domain (PD308398) which is seen in O82873_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 13:52:21 2006","Thu Sep 14 13:52:21 2006","Tue Aug 3 15:20:52 2004","Thu Dec 20 09:24:02 2001","","Thu Dec 20 09:24:02 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0749 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 09:25:19 2001","","No significant hits to the NCBI PDB database.","SMU.825","","No significant hits to the Pfam 11.0 database","Thu Dec 20 09:24:02 2001","24379280","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952","Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977","Tue Aug 3 15:30:25 2004","Tue Aug 3 15:30:25 2004","1","","","SMU.825","420" "SMu0750","771443","772378","936","ATGAAAGTTAATATTTTAATGTCCACCTACAATGGTCAGGAATTCATCGCCCAACAAATCCAAAGTATTCAAAAACAAACTTTTGAAAATTGGAACTTACTTATTCGCGACGATGGTTCTAGTGATGAAACTCCTAAAATTATTGCAGACTTTGCTAAGTCTGATGCGCGGATTCGTTTTATCAATGCTGATAAACGAGAAAATTTTGGTGTCATCAAAAATTTCTATACCTTACTAAAATATGAAAAGGCCGATTACTATTTTTTTAGCGATCAAGATGATGTTTGGCAGCCGCAAAAGCTGGAATTAACTCTGGCAAGTGTTGAAAAAGAAAACAATCAAATCCCTTTGATGGTTTATACAGATTTGACAGTAGTAGATAGAGATTTGCAAGTTTTGCATGATAGCATGATCAAAACACAGTCTCATCATGCCAATACTAGTTTACTTGAGGAATTAACAGAAAATACAGTTACTGGCGGGACTATGATGGTTAATCATTGTCTAGCTAAGCAGTGGAAGCAGTGTTATGATGACTTGATTATGCATGATTGGTATTTAGCGCTCCTTGCTGCCAGTCTAGGTAAATTGATTTATCTAGATGAGACCACAGAATTATACCGCCAGCATGAAAGTAATGTTTTGGGAGCTAGAACTTGGTCTAAACGTTTGAAAAATTGGCTGCGTCCCCATCGTTTGGTGAAAAAATACTGGTGGCTAGTAACATCAAGTCAGCAACAAGCCAGTCATTTATTGGAATTGGATTTGTCGGCAGCTAATAAGGCTATTATTCAAGCTTATGTGACTTTGTTGGATCAGTCGTTTTTAAACAGGATTAAATGGCTCAAACAATATGGTTTTGCTAAGAATCGTGCCTTTCATACTTTTGTTTTTAAGACATTGATTATTACTAAATTTGGTTATAGGAGAAAATAA","9.40","6.08","36596","MKVNILMSTYNGQEFIAQQIQSIQKQTFENWNLLIRDDGSSDETPKIIADFAKSDARIRFINADKRENFGVIKNFYTLLKYEKADYYFFSDQDDVWQPQKLELTLASVEKENNQIPLMVYTDLTVVDRDLQVLHDSMIKTQSHHANTSLLEELTENTVTGGTMMVNHCLAKQWKQCYDDLIMHDWYLALLAASLGKLIYLDETTELYRQHESNVLGARTWSKRLKNWLRPHRLVKKYWWLVTSSQQQASHLLELDLSAANKAIIQAYVTLLDQSFLNRIKWLKQYGFAKNRAFHTFVFKTLIITKFGYRRK","772377","For other 'rgp' genes see SMu0749 (rgpAc);SMu0751 (rgpCc); SMu0752 (rgpDc); SMu0753 (rgpEc) and SMu0754 (rgpFc).note=\"involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans\"","rhamnosyltransferase; polysaccharide biosynthesis protein","Cytoplasm","Matches in gapped BLAST to rhamnosyltransferase: residues 1-311 are 98% similar to the previously published enzyme in S.mutans (gi3399705).Residues 1-311 are 65% similar to the enzyme from S.pyogenes (gi15674831).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1422 (1e-101).","

InterPro
IPR001173
Domain

Glycosyl transferase, family 2
PF00535	$\"[4-174]T$	Glycos_transf_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[1-214]T$	G3DSA:3.90.550.10
PTHR22916	$\"[9-293]T$	PTHR22916
SSF53448	$\"[2-249]T$	SSF53448

","BeTs to 13 clades of COG0463COG name: Glycosyltransferases involved in cell wall biogenesisFunctional Class: MThe phylogenetic pattern of COG0463 is AMTKYQVCEBRHujGPo---XNumber of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 2-70 are 98% similar to a (TRANSFERASE COMPLETE PROTEOME GLYCOSYLTRANSFERASE) protein domain (PD000196) which is seen in O82874_STRMU.Residues 228-311 are 97% similar to a (TRANSFERASE RHAMNOSYLTRANSFERASE PROTEOME) protein domain (PD205671) which is seen in O82874_STRMU.Residues 84-228 are 26% similar to a (TRANSFERASE 2.-.-.- RFBB RFBG) protein domain (PD038354) which is seen in Q56900_YEREN.Residues 71-227 are 99% similar to a (TRANSFERASE PROTEOME COMPLETE) protein domain (PD038395) which is seen in O82874_STRMU.Residues 3-53 are 52% similar to a (BIFUNCTIONAL GLYCOSYLTRANSFERASE) protein domain (PD249528) which is seen in Q56900_YEREN.Residues 7-44 are 52% similar to a (CPS2F) protein domain (PD372766) which is seen in Q9ZII3_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 8 12:43:40 2007","Wed Aug 30 17:26:30 2006","Tue Aug 3 15:25:18 2004","Thu Dec 20 09:29:08 2001","","Thu Dec 20 09:29:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0750 is paralogously related (blast p-value < 1e-3) to SMu0753, a predicted glycosyltransferase rgpEc, SMu1876,a predicted stress response protein (glycosyltransferase) (sugar transferase) and SMu0758, a predicted conserved hypothetical protein; possible glycosyltransferase.","Thu Jan 24 13:04:12 2002","Tue Aug 3 15:25:18 2004","pdb1QGQA Chain A, Udp-Manganese Complex Of Spsa From Bacillus... 152 7e-038","SMU.826","","Residues 4 to 174 (E-value = 3.9e-26) place SMu0750 in the Glycos_transf_2 family which is described as Glycosyl transferase (PF00535)","Thu Dec 20 09:29:08 2001","24379281","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952","Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977","Tue Aug 3 15:31:02 2004","Tue Aug 3 15:25:18 2004","1","","","SMU.826","584" "SMu0751","772378","773187","810","ATGGACTTTTTTAGTCGTAAAAATCGTATTCTATTAAAAGAACTTATCAAGACTGATTTTAAACTTCGTTATCAAGGAAGCGCCATTGGCTACCTTTGGTCAATTTTGAAGCCTTTGATGCTGTTTGCTATCATGTACATTGTCTTTGTTCGTTTCTTACCTTTAGGGGGCGATGTGCCTCACTGGCCTGTTGCTCTCCTGCTAGGAAATGTTATTTGGACATTTTTCCAAGAAACAACCATGATGGGTATGGTTTCTGTTGTAACGCGTGGCGATTTACTGCGTAAACTTAATTTTTCGAAGCAGACGATTGTTTTTTCAGCAGTCTCTGGAGCTGCTATTAATTTTGGTATTAATGTAATTGTTGTTTTAATCTTTGCCCTTTTAAATGGTGTAACTTTTACTTTTAGATGGAATTTATTCTTGTTGATTCCGCTTTTCCTTGAGCTCTTGCTTTTCTCAACAGGGATTGCCTTTATTTTATCAACGCTTTATGTGAGATATCGTGACATTGGTCCTGTTTGGGAAGTTATTCTGCAAGGGGGGTTCTATGGAACGCCAATTATTTATTCTTTGACTTATATTGCTACTCGCAGTGTTGTAGGTGCTAAGCTTCTTTTATTGAGTCCAATTGCTCAAATTATTCAGGATATGCGGCACATTTTGATTGATCCAGCTAATGTTACTATTTGGCAGATGATTAATCATAAATCTATTGCTGTCATTCCATATCTTGTGCCTATTTTTGTGTTTATTATCGGTTTTCTTGTTTTCAATTATAATGCTAAGAAATTTGCGGAGATTATCTAA","10.70","10.71","30656","MDFFSRKNRILLKELIKTDFKLRYQGSAIGYLWSILKPLMLFAIMYIVFVRFLPLGGDVPHWPVALLLGNVIWTFFQETTMMGMVSVVTRGDLLRKLNFSKQTIVFSAVSGAAINFGINVIVVLIFALLNGVTFTFRWNLFLLIPLFLELLLFSTGIAFILSTLYVRYRDIGPVWEVILQGGFYGTPIIYSLTYIATRSVVGAKLLLLSPIAQIIQDMRHILIDPANVTIWQMINHKSIAVIPYLVPIFVFIIGFLVFNYNAKKFAEII","773186","For other components see SMu0752 (NBD1).For other 'rgp' genes see SMu0749 (rgpAc);SMu0750 (rgpBc); SMu0752 (rgpDc); SMu0753 (rgpEc) and SMu0754 (rgpFc).","polysaccharide ABC transporter membrane-spanning protein","Membrane, Cytoplasm","Matches in gapped BLAST to ABC-type transport protein rgpCc: residues 1-269 are 94% similar to the protein in S.mutans (gi7474169).Residues 15-269 are 62% similar to the protein from S.pyogenes (gi15674832).SMu0751 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000412
Family

ABC-2
PS51012	$\"[29-261]T$	ABC_TM2

InterPro
IPR013525
Domain

ABC-2 type transporter
PF01061	$\"[10-223]T$	ABC2_membrane

","BeTs to 6 clades of COG1682COG name: Membrane permeases involved in cell wall biosynthesisFunctional Class: MThe phylogenetic pattern of COG1682 is A----q-C-br-Uj------xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 227-269 are identical to a (PROTEOME COMPLETE POLYSACCHARIDE ABC) protein domain (PD206927) which is seen in O82875_STRMU.Residues 154-224 are identical to a (TRANSPORTER ABC PROTEOME COMPLETE) protein domain (PD186722) which is seen in O82875_STRMU.Residues 1-94 are identical to a (PROTEOME COMPLETE PERMEASE TRANSPORTER) protein domain (PD282487) which is seen in O82875_STRMU.Residues 95-139 are identical to a (ABC-TRANSPORTER) protein domain (PD198784) which is seen in O82875_STRMU.Residues 12-94 are 38% similar to a (TRANSPORT MEMBRANE POLYSACCHARIDE) protein domain (PD002060) which is seen in Q9JRP1_ACTAC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 22 12:55:58 2007","Thu Feb 22 12:55:37 2007","Tue Aug 3 15:27:43 2004","Thu Dec 20 09:35:19 2001","","Thu Dec 20 09:35:19 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0751 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 09:36:42 2001","","No significant hits to the NCBI PDB database.","SMU.827","","Residues 2 to 266 (E-value = 4.8e-87) place SMu0751 in the ABC2_membrane family which is described as ABC-2 type transporter (PF01061)","Thu Dec 20 09:35:19 2001","24379282","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952","Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977","Tue Aug 3 15:31:37 2004","Tue Aug 3 15:31:37 2004","1","","","SMU.827","" "SMu0752","773187","774404","1218","ATGACAAAAAATAATATTGCAGTCAAAGTTGACCATGTCAGTAAGTATTTTAAGTTACCTGTTGAAAGTACTCAAAGTTTGAGAACTGCCTTAGTCAATCGTTTTAAAGGGATTAAAGGTTATAAGAAACAGCATGTCCTGCGAGATATTGATTTCGAAGTTGAAAAAGGAGACTTTTTTGGTATTGTAGGCCGAAATGGTTCTGGTAAATCAACACTTTTAAAAATTATTTCTCAAATTTATGTTCCTGAACAAGGCAAAGTTACTGTAGATGGGAAATTAGTTTCTTTTATTGAACTCGGTGTCGGTTTTAATCCAGAACTGACTGGCCGTGAAAATGTTTATATGAATGGGGCTATGCTTGGTTTCACAACTGAAGAGGTAGATACTATGTATCAGGATATTGTAGACTTCGCAGAACTTCAAGATTTCATGAATCAAAAGCTGAAAAACTATTCTAGTGGGATGCAGGTGCGTCTTGCCTTCTCTGTTGCCATAAAAGCGCAAGGGGATGTCCTCATTCTTGATGAAGTTTTGGCGGTTGGTGATGAAGCCTTTCAGCGTAAATGTAATGATTACTTTTTGGAAAGAAAGAATAGCGGCAAGACTACTATCTTGGTAACGCACGATATGGCTGCAGTCAAGAAATATTGTAATAAAGCTGTTTTAATAGATGATGGTTTGATAAAGGCAATTGGTGAGCCATTTGATGTGGCTAACCAATACAGTTTAGATAATACAGACCAGATTGTTGAGGATAAACAAGAAGAGGAAGCAGCCGTTCAGGAAGAAGAGCAAATTGTTGTTGATAATCTTGAAGTAAAACTCCTGTCTGCTAATCGTATGACACCAAGAGACTCCATCCGTTTTGAAATTTCTTATAACGTTCTTGCAGATGTGGGAACATATATTGCTCTTTCTTTGACAGATGTTGATCGTAATATTTGGATTTATAATGACAATTCTTTAGACTATCTATCCAGTGGTTCAGGAAAGAAACGGGTTTTTTATGAATGCCATCTGAAAAGCTTAAATGATATTAAGTTAAAATTGGAAGTGACAGTTAGAGATAAGCAAGGGCAGATGTTGGCTTTTTCTAGTGCGACAAATACACCTATTATTTCTATTAATCGAGATGACCTTGAAGGTGATGACAAATCAGCTATGGACTCTGCCAGTGGACTTATTCAAAGGAATGGGCAGTGGCAATTTTCATAG","4.90","-11.14","45469","MTKNNIAVKVDHVSKYFKLPVESTQSLRTALVNRFKGIKGYKKQHVLRDIDFEVEKGDFFGIVGRNGSGKSTLLKIISQIYVPEQGKVTVDGKLVSFIELGVGFNPELTGRENVYMNGAMLGFTTEEVDTMYQDIVDFAELQDFMNQKLKNYSSGMQVRLAFSVAIKAQGDVLILDEVLAVGDEAFQRKCNDYFLERKNSGKTTILVTHDMAAVKKYCNKAVLIDDGLIKAIGEPFDVANQYSLDNTDQIVEDKQEEEAAVQEEEQIVVDNLEVKLLSANRMTPRDSIRFEISYNVLADVGTYIALSLTDVDRNIWIYNDNSLDYLSSGSGKKRVFYECHLKSLNDIKLKLEVTVRDKQGQMLAFSSATNTPIISINRDDLEGDDKSAMDSASGLIQRNGQWQFS","774403","For other components see SMu0751 (MSD1).For other 'rgp' genes see SMu0749 (rgpAc);SMu0750 (rgpBc); SMu0751 (rgpCc); SMu0753 (rgpEc) and SMu0754 (rgpFc).note=\"involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans\"","ABC transporter ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to ABC transporter rgpDc: residues 1-405 are 96% similar to the previously published protein in S.mutans (gi7430357). Residues 1-404 are 73% similar to the protein from S.pyogenes (gi15674833).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2129 (3e-22).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[152-190]T$	ABC_transporter
PF00005	$\"[57-227]T$	ABC_tran
PS00211	$\"[152-166]?$	ABC_TRANSPORTER_1
PS50893	$\"[27-251]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[56-246]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[38-243]T$	G3DSA:3.40.50.300
PTHR19222	$\"[8-17]T$ $\"[42-279]T$	PTHR19222
PTHR19222:SF2	$\"[8-17]T$ $\"[42-279]T$	PTHR19222:SF2
SSF52540	$\"[8-275]T$	SSF52540
SSF54637	$\"[297-372]T$	SSF54637

","BeTs to 6 clades of COG1134COG name: ABC-type polysaccharide/polyol phosphate transport system, ATPase componentFunctional Class: GThe phylogenetic pattern of COG1134 is A----q-C-br---------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.7e-24. IPB001140A 46-92 IPB001140B 149-187 IPB001140C 203-232","Residues 152-189 are identical to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD002039) which is seen in O82876_STRMU.Residues 100-150 are identical to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD051171) which is seen in O82876_STRMU.Residues 199-242 are identical to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174) which is seen in O82876_STRMU.Residues 270-404 are identical to a (ATP-BINDING PROTEOME COMPLETE) protein domain (PD206495) which is seen in O82876_STRMU.Residues 4-46 are identical to a (ATP-BINDING PROTEOME COMPLETE) protein domain (PD165914) which is seen in O82876_STRMU.Residues 46-219 are 27% similar to a (ATP-BINDING POLYSACCHARIDE TRANSPORT) protein domain (PD119675) which is seen in VEXC_SALTI.Residues 47-97 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in O82876_STRMU.Residues 152-190 are 64% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q47591_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 22 12:59:50 2007","Thu Feb 22 12:59:50 2007","Tue Aug 3 15:28:11 2004","Thu Dec 20 09:41:24 2001","Thu Dec 20 09:41:24 2001","Thu Dec 20 09:41:24 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0752 is paralogously related (blast p-value < 1e-3) to SMu1003, SMu0971, SMu1920, SMu1762, SMu0517, SMu0216, SMu0335, SMu0374, SMu0944, SMu0884, SMu0475, SMu0731, SMu0218, SMu0418, SMu1757, SMu0786, SMu0987, SMu0916, SMu1949, SMu0976, SMu0594, SMu0950, SMu0907, SMu0596, SMu0164, SMu1649, SMu0805, SMu1950, SMu1380, SMu0666, SMu0476, SMu1517, SMu1001, SMu1710, SMu1518, SMu1023, SMu0258, SMu1093, SMu1068, SMu1428, SMu1288, SMu1079, SMu0849, SMu0390, SMu0235, SMu1751, SMu1410, SMu1316, SMu1246, SMu1231, SMu1210, SMu0824, SMu1065, SMu0825, SMu1724, SMu0836, SMu0234, SMu0024, SMu1959, SMu1811, SMu1037, SMu0986, SMu0729, SMu1064, SMu1545, SMu1202, SMu1036, SMu0837, SMu0823, SMu1306, SMu1050, and SMu0224 all with ATP-binding capabilities..","Tue Jan 15 11:02:05 2002","Tue Aug 3 15:28:11 2004","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 82 1e-016pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 65 1e-011","SMU.828","","Residues 57 to 227 (E-value = 2.9e-39) place SMu0752 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Dec 20 09:41:24 2001","24379283","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952","Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977","Tue Aug 3 15:32:16 2004","Tue Aug 3 15:32:16 2004","1","","","SMU.828","" "SMu0753","774427","775824","1398","ATGGTAAAAGTATCCATTATTTGCACCAATTATAATAAAGGAAGCTGGATTGGTGAAGCTATTGATAGTTTCCTGAAACAAGAAACATCATTTCCATATGAAATCATAATTGTTGATGATGCTTCAACAGATCATTCAGTTCATATCATAAAAACCTATCAAAAACAGTATCCAGATTTAATTCGGGCTTTCTTTAATCAAGAAAATCAAGGAATTACAAAAACTTGGTCCGATATTTGTAAGAAAGCTAGAGGACAGTACATTGCCAGATGTGATGGTGATGATTATTGGATAGACCCTTTTAAGCTTCAAAAACAAATTGATCTTTTAGAGACATCTCCTGAATCAAAATGGTCTAATACAGACTTTGACATGGTGGACTCTAAAGGGAATATAATTCATAAAGATGTACTAAAAAATAATATTATCCCTTTTATGGATTCTTATGAAAAGATGCTTGCCTTAAAAGGGATGACGATGGCTTCCACTTGGTTGGTGGAAACTAAATTAATGTTAGAAATTAATGATCGAATTAATAAAGATGCCGTTGACGATACCTTCAATATCCAATTGGAATTATTTAAAAAAACTAAATTAGCGTTTTTAAGGGATTCTACAACCGTCTATCGTATGGATGCTGAGTCAGATTCACGTTCTAAGGATTCAGAAAAACTAGCCCAGCGATTTGATAGACTCTTAGAAACGCAGCTTGAGTATATTGAAAAGTACCCTGATAGTGATTATAAGAAAGTTCTAGAATATCTATTGCCTAAGCATAATGATTTTGAAAAAGTTCTGGCTCAGGATGGAAAAAATGTTTGGGATAATCAGCAGATTACCATTTATTTAGCTAAAGGAGATGATCAAGAATTTTCAGAAGAAAATTGTTTTCAGTTTCCTTTGCAGCATTCGGGCAATATTCAATTGACTTTTCCAGAAAATATACGGAAAATTCGGATTGATTTATCTGAAATCCCAAGTTACTATCGTCAAGTGTCATTGGTAAATACAACAGTTAATACAGAATTATTACCGACTTGGACCAATGCCAAAGTCTTTGGTTATTCTTATTATTTTATAGCTCCCGATCCTCAAATGATCTATGATTTAACCGCACAAGAAGGGCAAGACTTTAAACTGACTTATGAATGGTTTAATGTTGATCGGCCAAGTCAGCCTGATTTTTTAGCGAATCACTTAGTGAAGGAATTGGATCAAAAGAAGGTAGAGCTAAAAATGCTCAGTCCTTATAAGTATCAATATCAAAAAGCTGTTGCTGAGAGAGATTTGTATCTAGAACAGTTAAATGAGATGGTTGTCCGCTACAATTCAGTCACTCATTCCCGCCGTTGGACCATTCCTACAAAAATTATCAACTTATTCAGGAGAAAAAAATGA","5.50","-7.46","54879","MVKVSIICTNYNKGSWIGEAIDSFLKQETSFPYEIIIVDDASTDHSVHIIKTYQKQYPDLIRAFFNQENQGITKTWSDICKKARGQYIARCDGDDYWIDPFKLQKQIDLLETSPESKWSNTDFDMVDSKGNIIHKDVLKNNIIPFMDSYEKMLALKGMTMASTWLVETKLMLEINDRINKDAVDDTFNIQLELFKKTKLAFLRDSTTVYRMDAESDSRSKDSEKLAQRFDRLLETQLEYIEKYPDSDYKKVLEYLLPKHNDFEKVLAQDGKNVWDNQQITIYLAKGDDQEFSEENCFQFPLQHSGNIQLTFPENIRKIRIDLSEIPSYYRQVSLVNTTVNTELLPTWTNAKVFGYSYYFIAPDPQMIYDLTAQEGQDFKLTYEWFNVDRPSQPDFLANHLVKELDQKKVELKMLSPYKYQYQKAVAERDLYLEQLNEMVVRYNSVTHSRRWTIPTKIINLFRRKK","775823","For other 'rgp' genes see SMu0749 (rgpAc);SMu0750 (rgpBc); SMu0751 (rgpCc); SMu0752 (rgpDc) and SMu0754 (rgpFc).note=\"involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans\"","glycosyltransferase","Cytoplasm","Matches in gapped BLAST to glycosyltransferase rgpEc: residues 1-465 are 99% similar to the enzyme in S.mutans (gi7474172). Residues 1-256 are 59% and residues 209-465 are 20% similar to the protein from S.pyogenes (gi15674834).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1164 (5e-11).","

InterPro
IPR001173
Domain

Glycosyl transferase, family 2
PF00535	$\"[5-111]T$	Glycos_transf_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[3-219]T$	G3DSA:3.90.550.10
PTHR22916	$\"[10-243]T$	PTHR22916
SSF53448	$\"[3-229]T$	SSF53448

","BeTs to 13 clades of COG0463COG name: Glycosyltransferases involved in cell wall biogenesisFunctional Class: MThe phylogenetic pattern of COG0463 is AMTKYQVCEBRHujGPo---XNumber of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 3-53 are identical to a (TRANSFERASE COMPLETE PROTEOME GLYCOSYLTRANSFERASE) protein domain (PD000196) which is seen in O82877_STRMU.Residues 4-88 are 43% similar to a (TRANSFERASE GLYCOSYL PROTEOME COMPLETE) protein domain (PD331656) which is seen in P71795_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 27 12:11:00 2007","Tue Mar 27 12:11:00 2007","Tue Aug 3 15:28:47 2004","Thu Dec 20 09:48:14 2001","","Thu Dec 20 09:48:14 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0753 is paralogously related (blast p-value < 1e-3) to SMu0750, a predicted rhamnosyltransferase.","Thu Jan 24 13:23:24 2002","","No significant hits to the NCBI PDB database.","SMU.829","","Residues 5 to 187 (E-value = 1.9e-28) place SMu0753 in the Glycos_transf_2 family which is described as Glycosyl transferase (PF00535)","Thu Dec 20 09:48:14 2001","24379284","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952","Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977","Tue Aug 3 15:32:52 2004","Tue Aug 3 15:32:52 2004","1","","","SMU.829","" "SMu0754","775821","777572","1752","ATGAAGCGCCTGCTTTTATATGTTCATTTTAATAAATACAATCGGGTAAGTTCCCATGTCGTTTATCAGTTGACTCAAATGAGATCCTTGTTTTCAAAAGTTATCTTTATTTCAAATAGCCAAGTGGCAGATGCGGATGTCAAAATGCTAAGAGAAAAGCATCTCATTGATGACTTCATTCAACGGCAGAATTCTGGATTTGACTTTGCAGCTTGGCGAGATGGAATGGTCTTTGTCGGTTTTGATGAACTTGTGACATATGACTCGGTAACAACCATGAATGACACTTGTTTTGGACCTCTTTGGGAAATGTATTCAATTTATCAAGAATTTGAAACCAAGACGACAGTTGATTTTTGGGGATTGACCAACAACCGTGCAACCAAGTCATTTCGTGAGCATATTCAAAGTTACTTTATTTCATTTAAAGCATCTGTTTTAAGAAGCACCGCTTTCAGAGACTTTTGGGAAAATATAAAAGAGTATCAGGATGTTCAAAAGGTGATTGATCAGTATGAAACAAAGGTCACGACAACTCTCTTAGATGCTGGTTTTCAATATGATGTCGTTTTTGATACGACCAAGGAAGATGCTTCGCATATGCTTCATGCAGACTTCTCTTACTATAATCCAACAGCTATTTTGAATCATAGGGTGCCCTTTATCAAGGTTAAAGCGATTGACAATAATCAACATATTACGCCCTATCTTTTAAATGATATTCAAAAGAATTCGACCTATCCTATTGATTTAATTGTTTCGCACATGTCAGAAATCAATTATCCTGATTTTAGTTATTTATTGGGTCACAAATATGTCAAGAAAAGAGAAAGAGTTGATTTAAAGAATCAAAAAGCTGCGGTTCATCTCCATGTGTTTTATGTGGATTTGCTGGAAGAATTTTTAACGGCATTTAAGCAATTTCATTTTTCTTATGATTTATTTATAACGACAGATAGTGATGATAAGAAAGCTGAAATTGAAGAGATTCTATCTGCAAACAGTCAAGAGGCTCAGGTTTTTGTCACAGGCAATATTGGACGTGATGTTCTTCCTATGTTAAAATTAAAAAATTATTTATCTACCTATGATTTTGTTGGTCATTTTCATACCAAAAAGTCAAAGGAGGCTGATTTTTGGGCTGGCCAATCTTGGCGGGAAGAATTAATTGACATGTTGGTTAAACCAGCAGACAATATTTTAGCGCAATTACAGCAAAACCCCAAAATTGGTTTGGTGATTGCTGATATGCCAACTTTCTTTCGCTATAATAAAATTGTTGATGCTTGGAATGAACATTTGATTGCACCTGAGATGAATACATTATGGCAAAAGATGGGCATGACCAAAAAGATTGATTTCAATGCTTTTCACACTTTTGTCATGAGTTATGGCACTTTTGTTTGGTTTAAATATGATGCCTTAAAACCGCTCTTTGATTTAAATCTGACAGATGATGATGTGCCTGAGGAACCTTTGCCGCAAAATTCTATTTTACATGCTATTGAGCGTTTATTGATCTACATTGCTTGGAATGAGCATTACGATTTTAGAATTTCTAAAAATCCAGTTGATCTGACGCCTTTCATAGATAATAAATTATTAAATGAACGTGGCAACTCAGCACCAAATACCTTTGTTGATTTTAACTATATGGGAGGAATAAAGGGAGCTTTTAAATATATTTTCATTGGTCCAGCTAGGGCTGTCAAATATATCCTGAAGCGTTCTCTGCAAAAAATAAAGTCATGA","6.70","-3.43","68339","MKRLLLYVHFNKYNRVSSHVVYQLTQMRSLFSKVIFISNSQVADADVKMLREKHLIDDFIQRQNSGFDFAAWRDGMVFVGFDELVTYDSVTTMNDTCFGPLWEMYSIYQEFETKTTVDFWGLTNNRATKSFREHIQSYFISFKASVLRSTAFRDFWENIKEYQDVQKVIDQYETKVTTTLLDAGFQYDVVFDTTKEDASHMLHADFSYYNPTAILNHRVPFIKVKAIDNNQHITPYLLNDIQKNSTYPIDLIVSHMSEINYPDFSYLLGHKYVKKRERVDLKNQKAAVHLHVFYVDLLEEFLTAFKQFHFSYDLFITTDSDDKKAEIEEILSANSQEAQVFVTGNIGRDVLPMLKLKNYLSTYDFVGHFHTKKSKEADFWAGQSWREELIDMLVKPADNILAQLQQNPKIGLVIADMPTFFRYNKIVDAWNEHLIAPEMNTLWQKMGMTKKIDFNAFHTFVMSYGTFVWFKYDALKPLFDLNLTDDDVPEEPLPQNSILHAIERLLIYIAWNEHYDFRISKNPVDLTPFIDNKLLNERGNSAPNTFVDFNYMGGIKGAFKYIFIGPARAVKYILKRSLQKIKS","777571","For other 'rgp' genes see SMu0749 (rgpAc);SMu0750 (rgpBc); SMu0751 (rgpCc); SMu0752 (rgpDc) and SMu0753 (rgpEc).note=\"involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans\"","polysaccharide biosynthesis protein","Cytoplasm","Matches in gapped BLAST to rgpFc protein: residues 1-583 are99% similar to the protein in S.mutans (gi15674251). Residues1-582 are 65% similar to the protein from S.pyogenes (gi15674835).SMu0754 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000209
Domain

Peptidase S8 and S53, subtilisin, kexin, sedolisin
PS00136	$\"[178-188]?$	SUBTILASE_ASP

InterPro
IPR007739
Family

Rhamnan synthesis F
PF05045	$\"[34-515]T$	RgpF

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-239 are identical to a (VIRULENCE GLYCOSYLTRANSFERASE Y4GN) protein domain (PD040533) which is seen in O82878_STRMU.Residues 240-279 are identical to a (RGPFC) protein domain (PD373053) which is seen in O82878_STRMU.Residues 280-412 are 97% similar to a (XANA PROTEOME 5'REGION COMPLETE) protein domain (PD152537) which is seen in O82878_STRMU.Residues 413-548 are identical to a (PROTEOME COMPLETE RGPFC POLYSACCHARIDE) protein domain (PD155761) which is seen in O82878_STRMU.Residues 549-583 are identical to a (RGPFC) protein domain (PD179635) which is seen in O82878_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 22 13:06:30 2007","Thu Feb 22 13:06:30 2007","Tue Aug 3 15:29:25 2004","Thu Dec 20 09:51:20 2001","","Thu Feb 22 13:06:30 2007","yes","Fri Feb 20 15:41:32 MST 1998","SMu0754 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 09:51:49 2001","","No significant hits to the NCBI PDB database.","SMU.830","","No significant hits to the Pfam 11.0 database","Thu Dec 20 09:51:20 2001","24379285","","Yamashita,Y., Shibata,Y., Nakano,Y., Tsuda,H., Kido,N., Ohta,M. and Koga,T.A novel gene required for rhamnose-glucose polysaccharide synthesis in Streptococcus mutansJ. Bacteriol. 181 (20), 6556-6559 (1999)PubMed: 10515952","Shibata Y, Yamashita Y, Ozaki K, Nakano Y, Koga T.Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli.Infect Immun. 2002 Jun;70(6):2891-8.PMID: 12010977","Tue Aug 3 15:33:25 2004","Tue Aug 3 15:33:25 2004","1","","","SMU.830","" "SMu0755","777569","780109","2541","ATGAAACAATTGAAAAAAATATGGGATATGCTTGGAAAGCAAAAATTACTTATTTTCATTTTCATTTTTGCTCTTAATGTCACATTAAGAAATTATGATCTTTTAATAGGACGTAGAGCAAATTCATCTTTGTCTTTTAAAGTCATTTCGAAAAACTTTGATATTATGATAGAGCATTGGGAAGCATTGCCTAGTCATTTTAAAATTATCGGGGGAGTTTGTCTTGTTATTTATGTTCTCTCCATTTTAGGACTATCGTTCTATTTATCTAAAAATCTAAAGAAAACTTTTTTTATAGAATTATTGTTAGGATATGGTCTTTATATAGTAATATCCTATTTTCTAGCTGTTACCAGAGAATTAAATAATGAGTCTTTTAAGATTTGGGATTTGGCAAAAAATCACTTCTTTCAGCCTTATTTTTTACCGACTTTAGTTTTAATTATTGTTTGCACACTTGCTTTGAATTATCTTATAAGAGTGAAAATGAAGAGATCACATTTGTCTCGGAAAATGACTCTACTTTTAGAGAACTTTTCTGAAACTGAATTTCTTCTAACTGGATTAATTGTTTCTTTTATTCTTAGCGATACGCTTTATGTTAAACTTTTACAGGAATCATTAAGGGCTTATTACCACAAACCTCTTGCCTATGAAAGTCTTTTATTTCTTTATACTTTGCTAACGTTAATCTTGTTTAGTGTGATTGTAGAAGCTTGTTTTAATGCTTATCGTTCTATCAAATTGAATCGTCCCAATCTCTCCCTAGCCTTTGTTTCCAGTCTTTTATTTGCTACTATCTTTAACTATGCTTTTCAATACGGCTTAAAAAATGATGCTGATTTATTAGGTAAGTATATTGTTCCGGGAGCAACTGCTTACCAGATATTGGTATTGACAGCGGCTGGTTTTTTCTTATACTTGATCATTAATCGCTATCTACTTGTAACTTTTCTAATTGTTATTTTAGGATCAATTATTACTGTCGTTAATGTCCTTAAGGTAGGTATGCGTAATGAACCTCTGCTAGTGACAGATTTTGCATGGGTTACTAATATAAGATTGTTAGCACGTTCTGTTAATGCTAATATTATTTTTAGTACTCTATTAATTTTAGCTGCTCTGATTCTGTTATATTTGTTCCTTAGAAAACGTTTGCTGCAAGGAAAAATTACGGAAAATCATCGGTTAAAAGTAGGGCTTATCTCTTCTATTTGTCTTCTTGGGTTTAGTATTTTTATCATCTTTAGAAATGAGAAAGGCAGCAAAATTGTAAATGGGATTCCTGTAATATCTCAGGTTAATAATTGGGTTGATATAGGCTATCAAGGCTTTTATTCGAATGCTAGTTATAAATCTCTGATGTATGTTTGGACAAAGCAGGTAACCAAGTCTATTATGGATAAACCGTCAGACTACAGTAAAGAGCGTATTCTTAAATTAGCTAAGAAATATAATAATGTAGCTAATAAAATCAATAAGGTTCGAACAGAAAATATTTCAAATCAGACAGTTATCTATATTTTAAGTGAAAGTTTTTCGGATCCTGATCGTGTTAAAGGAGTTAACCTTAGTCGTGATGTTATTCCTAATATTAAACAGATTAAAGAAAAAACAACTAGCGGATTAATGCATTCAGATGGCTATGGCGGTGGTACTGCCAATATGGAATTTCAATCATTAACTGGTTTGCCATACTATAATTTTAACTCTTCGGTTTCAACTCTCTATACCGAGGTTGTTCCTGATATGTCTGTTTTTCCTTCCATCAGTAATCAGTTTAAATCAAAAAATCGAGTTGTTATTCACCCATCTTCGGCTTCAAATTATTCTAGAAAATATGTTTATGATAAATTAAAATTTCCGACTTTTGTTGCTTCCAGTGGAACCAGTGACAAAATTACTCATTCTGAAAAAGTGGGACTTAATGTTAGTGATAAAACAACTTATCAGAATATTTTAGATAAGATTAATCCTTCTCAAAGTCAATTTTTCTCTGTAATGACAATGCAAAATCATGTACCTTGGGCATCGGATGAGCCAAGTGATGTGGTTGCTACTGGCAAGGGCTATACAAAAGATGAAAATGGTTCTTTATCTAGTTATGCGCGATTGCTGACCTATACAGATAAAGAAACGAAAGATTTTTTAGCCCAACTTTCGCAGCTGAAACACAAAGTAACAGTTGTTTTTTATGGAGACCATTTACCTGGTTTGTATCCTGAAAGTGCTTTTAAAAAAGATCCGGACAGTCAATATCAAACAGATTACTTTATCTGGAGTAATTATAATACCAAGACTTTGAATCATTCTTATGTTAATTCTAGTGATTTTACAGCTGAACTTCTAGAACATACCAATTCGAAAGTTTCGCCTTATTACGCTCTATTAACAGAAGTTTTAGATAATACTACTGTTGGTCATGGAAAACTGACTAAAGAACAAAAAGAAATTGCTAACGATTTGAAGCTTATACAATATGATATAACTGTAGGAAAGGGATATATCAGAAACTATAAAGGATTCTTTGACATTCGATAA","10.30","32.45","96532","MKQLKKIWDMLGKQKLLIFIFIFALNVTLRNYDLLIGRRANSSLSFKVISKNFDIMIEHWEALPSHFKIIGGVCLVIYVLSILGLSFYLSKNLKKTFFIELLLGYGLYIVISYFLAVTRELNNESFKIWDLAKNHFFQPYFLPTLVLIIVCTLALNYLIRVKMKRSHLSRKMTLLLENFSETEFLLTGLIVSFILSDTLYVKLLQESLRAYYHKPLAYESLLFLYTLLTLILFSVIVEACFNAYRSIKLNRPNLSLAFVSSLLFATIFNYAFQYGLKNDADLLGKYIVPGATAYQILVLTAAGFFLYLIINRYLLVTFLIVILGSIITVVNVLKVGMRNEPLLVTDFAWVTNIRLLARSVNANIIFSTLLILAALILLYLFLRKRLLQGKITENHRLKVGLISSICLLGFSIFIIFRNEKGSKIVNGIPVISQVNNWVDIGYQGFYSNASYKSLMYVWTKQVTKSIMDKPSDYSKERILKLAKKYNNVANKINKVRTENISNQTVIYILSESFSDPDRVKGVNLSRDVIPNIKQIKEKTTSGLMHSDGYGGGTANMEFQSLTGLPYYNFNSSVSTLYTEVVPDMSVFPSISNQFKSKNRVVIHPSSASNYSRKYVYDKLKFPTFVASSGTSDKITHSEKVGLNVSDKTTYQNILDKINPSQSQFFSVMTMQNHVPWASDEPSDVVATGKGYTKDENGSLSSYARLLTYTDKETKDFLAQLSQLKHKVTVVFYGDHLPGLYPESAFKKDPDSQYQTDYFIWSNYNTKTLNHSYVNSSDFTAELLEHTNSKVSPYYALLTEVLDNTTVGHGKLTKEQKEIANDLKLIQYDITVGKGYIRNYKGFFDIR","780108","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical protein 7: residues 44-846 are 93% similar to the previously published protein in S.mutans (gi|7474175|).Residues 73-845 are 46% similar to the protein in S.pyogenes (gi|15674836|). SMu0755 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000917
Domain

Sulfatase
PF00884	$\"[501-838]T$	Sulfatase

noIPR
unintegrated

unintegrated
SSF53649	$\"[502-735]T$	SSF53649

","BeTs to 3 clades of COG1368COG name: Phosphoglycerol transferase MdoB and related proteins, alkaline phosphatase superfamilyFunctional Class: MThe phylogenetic pattern of COG1368 is ------v-eB-Huj-------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 788-846 are identical to a (ORF7) protein domain (PD185029) which is seen in O82879_STRMU.Residues 638-835 are 20% similar to a (CYCLIC BETA-12-GLUCAN TRANSMEMBRANE) protein domain (PD144484) which is seen in CGMA_RHIME.Residues 505-787 are 99% similar to a (CAPSULAR PROTEOME RKPI COMPLETE) protein domain (PD025398) which is seen in O82879_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 13:26:27 2002","Fri Apr 26 11:18:11 2002","Thu Jan 24 13:30:05 2002","Thu Dec 20 10:03:11 2001","","Thu Dec 20 10:03:11 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0755 is paralogously related (blast p-value < 1e-3) to SMu0703, a predicted conserved hypothetical protein.","Thu Jan 24 13:25:19 2002","","No significant hits to the NCBI PDB database.","SMU.831","","No significant hits to the Pfam 11.0 database","Thu Dec 20 10:03:11 2001","24379286","","Yamashita Y, Tsukioka Y, Tomihisa K, Nakano Y, Koga T.Genes involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans.J Bacteriol. 1998 Nov;180(21):5803-7.PMID: 9791140 ","","Tue Mar 26 14:46:26 2002","","1","","","SMU.831","" "SMu0756","780146","781462","1317","ATGCTAATATATAGAAGGAGAGTATTTATGGAAAAGGTAATAAGTTTTATTAAGAATCATTACCGCCTATTGTTATTTTATTTTATTGTCAGTATTATTTTTACATTAGAGCTGGTAGTATATATTAATGATGCAGGAGATCAAACGATCTTTGCGCATGAATTAAGTAAACATGGTTTCTTTGAGTATGCCATTTATCGCTATCAAACTTGGTCAAGTAGATTGCTTATTGAATCAGTGACGATGTTTATGTCAGGACATCATTATATTATTTTTGATATTTCTTTATTAGGTTTAACCTTTCTCTTCTTATATGCTTTGAAGCAGATTATTCTTCCTGAAAAGGGTTATCTATATGTAAAATATAGTCTTCCAATAGTTTTTATCGTTATTTTTCCCGGAGTGCTTTTTACAAGTGCTGGTTTAATTCCTACAGTAACGAATTACTTATTCCCTATGTTTGCACTAGTAATTGGATGGTGTTTATTAAATCAGAAAAATAACTTCTCTGTATTGTTAGCATTTATTGCTATTAGTTTTGCTTTTATGCAAGAACAGTTCACTGTTTTAGGATTTCTTATTATAGGTTTTCTTCTTATAGCAGAATTTGTTAAAAATCAAAAAATTAATATGAGATATTTAGGAGCATTTGGTGTTTCTTTATTAGGTCTTATATCAGCATTCTTTTCTCCAGGTTCTGACAGTCGTCTCTCGCAAGAGATTGCCACTTGGTATCCCGGTTTTAATAAATTATCTCTAATAACGAAAATTCTAAAAGGTTATTTGGAAACAAACAGAATTATTTTTGTAACCGCAGAATTAAATATTTTCTTTATACTATTGCTTATAATTATTATTCTATCTCTTCTAAAGAAACAATTTTTCTCAACAGTTGCTATAAGTTTTATAGTGTATACACTCATTATAAATAAGTTAGGTATCAGTAATTTATTTACAGCAATACAAAAAATTGTTGATACTCAAAATGTAAGGAAAAATCATCTTTATTTTAGTATTAAAGAGAATTTATACCCGTTGATTATTTATACGGCTTTGCTATTAATAATAACTGTTGTTATCTTTTACTTATTTGAAGAAAAAATAAAGGGTTTGCTGGCCGTGGTTATCTTGGTTGCAGGATATGCTTCAAGAATGCTAGTCTCTTTGTCGCCAACTATTTATGCTTCTCAACTCAGAACTTATATTCCATTACTTTTTGCCGTCTTCATTGTAATTTTACTTCTTTTGAAAGAGGGATATCCCTTACTTAAAGAAAAGGTGAGATGGCAAGAAGGAAAATTTAAATCCAATTATTAA","10.40","17.39","50585","MLIYRRRVFMEKVISFIKNHYRLLLFYFIVSIIFTLELVVYINDAGDQTIFAHELSKHGFFEYAIYRYQTWSSRLLIESVTMFMSGHHYIIFDISLLGLTFLFLYALKQIILPEKGYLYVKYSLPIVFIVIFPGVLFTSAGLIPTVTNYLFPMFALVIGWCLLNQKNNFSVLLAFIAISFAFMQEQFTVLGFLIIGFLLIAEFVKNQKINMRYLGAFGVSLLGLISAFFSPGSDSRLSQEIATWYPGFNKLSLITKILKGYLETNRIIFVTAELNIFFILLLIIIILSLLKKQFFSTVAISFIVYTLIINKLGISNLFTAIQKIVDTQNVRKNHLYFSIKENLYPLIIYTALLLIITVVIFYLFEEKIKGLLAVVILVAGYASRMLVSLSPTIYASQLRTYIPLLFAVFIVILLLLKEGYPLLKEKVRWQEGKFKSNY","781461","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu0756 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[23-43]?$ $\"[89-107]?$ $\"[122-140]?$ $\"[146-164]?$ $\"[169-203]?$ $\"[209-229]?$ $\"[268-288]?$ $\"[294-314]?$ $\"[342-362]?$ $\"[368-388]?$ $\"[398-416]?$	transmembrane_regions

InterPro
IPR001173
Domain

Glycosyl transferase, family 2
PF00535	$\"[5-171]T$	Glycos_transf_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[3-123]T$	G3DSA:3.90.550.10
PTHR10859	$\"[10-307]T$	PTHR10859
SSF53448	$\"[3-170]T$	SSF53448

","BeTs to 12 clades of COG0463COG name: Glycosyltransferases involved in cell wall biogenesisFunctional Class: MThe phylogenetic pattern of COG0463 is AMTKYQVCEBRHujGPo---XNumber of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 4-75 are 36% similar to a (TRANSFERASE COMPLETE PROTEOME GLYCOSYLTRANSFERASE) protein domain (PD000196) which is seen in O67737_AQUAE.Residues 140-225 are 77% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD360542) which is seen in Q9CJ93_LACLA.Residues 4-128 are 49% similar to a (PROTEOME COMPLETE TRANSFERASE) protein domain (PD319470) which is seen in Q9CJ93_LACLA.Residues 226-306 are 35% similar to a (TRANSFERASE PROTEOME COMPLETE GLYCOSIL) protein domain (PD392195) which is seen in Q9CJ93_LACLA.Residues 91-128 are 60% similar to a (TRANSFERASE PROTEOME COMPLETE SYNTHASE) protein domain (PD395383) which is seen in YKCC_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 13:20:28 2002","Thu Sep 14 14:16:16 2006","Thu Sep 14 14:16:16 2006","Thu Dec 20 10:13:55 2001","","Thu Dec 20 10:13:55 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0757 is paralogously related (blast p-value < 1e-3) to SMu1876, a predicted stress response protein (glycosyltransferase) (sugar transferase) and SMu0758, a predicted conserved hypothetical protein; possible glycosyltransferase.","Wed Mar 20 13:20:28 2002","","No significant hits to the NCBI PDB database.","SMU.833","","Residues 5 to 171 (E-value = 1.3e-32) place SMu0757 in the Glycos_transf_2 family which is described as Glycosyl transferase (PF00535)","Thu Dec 20 10:13:55 2001","24379288","","","","","","1","","","SMU.833","424" "SMu0758","782537","783475","939","ATGACAGAGAAAATTGCAATATTACTTCCAGCTTACAATGAAGAGATTACTATTCAAAAAGTTATCTCTGATTTTAAGCGAGTCTTACCGGAAGCTGACATTTATGTTTATGATAATAATTCTAAAGACAGAACAAATGAATTAGCTCGTCAAGCTGGTGCGATTGTTCGTTTTGAATCTCGTCAAGGAAAGGGAAATGTTGTTCGTTCAATGTTTCGTGAAATTAATGCAGATTACTATATCATGGTTGATGCAGATGATACCTACCCAGCAGACGAGGTGCAAAAGCTTTTAGATCCTTTACGTTCTGGTAAAGCTGATATGACCATTGGAGATCGTCTATCTAATGGGACTTATGCTGAAGAAAATAAGCGTGGGTTTCATGGCTTCGGCAATAATTTAGTACGACTTTTAGTTAATCACCTTTACCAAGGAAATTATCAGGATATTATGACGGGATATCGTGGCTTTAATCGTCTCTTTGTTAAGAATTTTCCTGTCTTATCATCAGGATTCGAGATTGAGACTGAATTGTCAATCCATTCGCTTGACAAACGTTTTAAACTAGTCGAAGTGCCTATTACATATCATGATCGTCCCGAGGGCAGTGAATCTAAACTGAATACCTTCTCGGATGGTTTTAAAGTACTTTGTATGATTTTTAATCTCTTTAAAGATTATAAGCCACTCATATTCTTTAGTCTTGTGACTTTATTTTTCTTTATTTTAGGTCTTATCGTAGGTGTTCCTGTTGTGACGGAATTTGCAGAAACAGGCTTTATTGCTAAAATGCCATCAGCTATTTTAGCAACAGGTTTTATGATTTTAGCAGCCTTGTCTTTTGCGTTAGGTTTTATTTTAGATACTATTGTTCGTCAGAATCGTATGCAATATGAACTGAAAATTTATGACTATTATGAGCGTAATGGCCGTAAATAG","6.60","-1.07","35767","MTEKIAILLPAYNEEITIQKVISDFKRVLPEADIYVYDNNSKDRTNELARQAGAIVRFESRQGKGNVVRSMFREINADYYIMVDADDTYPADEVQKLLDPLRSGKADMTIGDRLSNGTYAEENKRGFHGFGNNLVRLLVNHLYQGNYQDIMTGYRGFNRLFVKNFPVLSSGFEIETELSIHSLDKRFKLVEVPITYHDRPEGSESKLNTFSDGFKVLCMIFNLFKDYKPLIFFSLVTLFFFILGLIVGVPVVTEFAETGFIAKMPSAILATGFMILAALSFALGFILDTIVRQNRMQYELKIYDYYERNGRK","783474","","glycosyltransferase","Membrane, Cytoplasm","Matches in gapped BLAST to unknowns and glycosyltransferase: residues 1-309 are 61% similar to an unknown in Listeria monocytogenes (gi4104144).Residues 4-309 are 63% similar to the enzyme in Clostridium acetobutylicum (gi15895591).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1421 (2e-13).","

InterPro
IPR001173
Domain

Glycosyl transferase, family 2
PF00535	$\"[6-161]T$	Glycos_transf_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[4-208]T$	G3DSA:3.90.550.10
PTHR10859	$\"[11-308]T$	PTHR10859
SSF53448	$\"[4-206]T$	SSF53448

","BeTs to 10 clades of COG0463COG name: Glycosyltransferases involved in cell wall biogenesisFunctional Class: MThe phylogenetic pattern of COG0463 is AMTKYQVCEBRHujGPo---XNumber of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 5-68 are 73% similar to a (TRANSFERASE COMPLETE PROTEOME GLYCOSYLTRANSFERASE) protein domain (PD000196) which is seen in Q9ZIC5_LISMO.Residues 69-139 are 42% similar to a (PROTEOME COMPLETE RFBJ) protein domain (PD350147) which is seen in P73444_SYNY3.Residues 223-295 are 46% similar to a (PROTEOME RFBJ-GND COMPLETE ORF10X9) protein domain (PD021486) which is seen in Q9ZIC5_LISMO.Residues 72-116 are 60% similar to a (PROTEOME COMPLETE TRANSFERASE) protein domain (PD263808) which is seen in Q9ZIC5_LISMO.Residues 139-220 are 67% similar to a (PROTEOME COMPLETE SYNTHASE MANNOSE) protein domain (PD336873) which is seen in Q9ZIC5_LISMO.Residues 55-217 are 26% similar to a (PROTEOME COMPLETE) protein domain (PD086719) which is seen in P72930_SYNY3.Residues 143-207 are 43% similar to a (TRANSFERASE SYNTHASE PROTEOME) protein domain (PD001307) which is seen in O29860_ARCFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 13:22:27 2002","Tue Mar 27 12:12:28 2007","Thu Feb 8 15:27:54 2007","Thu Dec 20 10:19:47 2001","","Thu Dec 20 10:19:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0758 is paralogously related (blast p-value < 1e-3) to SMu0757, a predicted glycosil transferase, SMu1876,a predicted stress response protein (glycosyltransferase) (sugar transferase), SMu1308,a predicted conserved hypothetical protein,possible glycosil transferase and SMu0750, a predicted rhamnosyltransferase.","Thu Jan 24 13:35:32 2002","","No significant hits to the NCBI PDB database.","SMU.834","","Residues 6 to 165 (E-value = 5.5e-20) place SMu0758 in the Glycos_transf_2 family which is described as Glycosyl transferase (PF00535)","Thu Dec 20 10:19:47 2001","24379289","","","","","","1","","","SMU.834","" "SMu0759","783609","785420","1812","TTGAATAAGAATGTGACTATTAAAAAAAGTACTCTATTTTATATTATATTATGTTTCATTGGAATTTTTCGAATAGCCTTATTGAGAAGTGCTCCATGGGAGTTGGATGCTAATACAGGTTATGATGATTTACTGCAGCTTAAAAATGCTATTTCAATTGCTTCAGGAAATTGGTTGGGTAAAACTTATTCTTATATTTCAATGACTAAAAATGTAGGCTACCCTCTTTTTCTTGCTCTAACTCAGCTGTTAAATATCCCTTATAGCGTACTTTATGGCTTGTTAATCAGTCTGTCTAGTTTTAGTTTTATAAAGGCCATTCAGCCTGTAGTAAAAAGTAAAAAATTACTGTTGCTTATCTTTTTTGTTATTATTTTTACGCCTATCAATCATGGTGCTTTTTATCGCATTTATCGTAATGCACTGGTTCCATGGGTTCTGTTACTTATTATATCTAGTTACATTGCTATCTTTATAAGACGTCGCGATAGATTATCTTTGTTTTTACCGTGGACTATTTTAGCTTTCTTTTCTATCATGTATTTTTGGACATTGCGGGAAGATTCTATTTGGATTTTACCTTTTATATTAGTTGCTGCTATAACAATTATTATAACAATTGTTATTCTTTATAAAAAGGATCTACATGAAATTTTATTAAGGAGTGTCCTTGTATTATTACCTTTAATTGGTATAGTTGTTAGTAATGTTTGGGTCTCAGCTATTAACTATAGCTATTATGGCATATGGGGCGTTAATGATCGCTCTGATACAGCTGCAGCAAAAGCTATGAGTCTCATTTATAAAATTGAAGATAATCAAACAACTGACAGTACTGTTTGGGCGTCACGAAAAGCTTTCGAATTAGCTATTAAAGCAAGTCCGAGTTTACGAACAGTAGGAAATACAGTTTTAGCTTCGTATGGTCTATGGGCTGGTAAAAATACTGATATTAAAGGAGATATTGCTCAATGGGCTTTTCGATTTGGTGTAGAAGAAGAGGGTTATTATCATGGTAATGGCAAAAAAACCAATGCTCTTTATAAAGCTATAGCAAATGAACTGGGGGAAGCTTTTCAAAAGGGAAGGTTAAAGAAACGCGATGGTATCTATCTCTCCACACAAACAGGTGCCTTCCATTGGAAAGATATTAGTCAATCTATGACCATGTCACTGGATCTGACGAATAAAATGTTTCATTTCTATAATACAAATTTATCATCAGGTTATATAGATTATCCTAATTTAACAGAGACTGAGCTTATTTCTTACGAAGACATGCTGAATACTTCCTTGCCTAGAACTAATGATCAGTTAAGTGCAGTAGGGATCACAAAGACCTACAGTGATTATGATGTCAATTTAACTAGTCTTTCAAATCACTATCAGCAATTAAATGCTAGTATTTTTAGAAGAAGAAATTATTATATTAATTTCCAAGAAAAGCTTATCAAATGTTATCAGGTTGTGTCCTATTTTATGTTTCCCTTGTCTTTTCTTGCTTATTTGATCTTAATTATTGATGGTTTTAGACATCAATTCACAGCTAATAATCTTAGTAAATTAATTATACTATCTTCTCTATTACTAACAGGGATTCTAAATCTTTTTATTGTTAGTCTGTTTTCAAGATGGATTGACCCAAATACGGATTCTTTCATTTATGGTTTCTATGCTCCATCAGCTTATCTGTTATTTAACCTATTTATGTGCATGGGAGGAATAGTACTTTTTGAAAAATTATGTTCGTCAAGAATGCTAAAAAACTTTTTGTCAACTGTAGGCAATTATATGGGTAGGCACAGAGATTAA","10.20","19.74","69057","MNKNVTIKKSTLFYIILCFIGIFRIALLRSAPWELDANTGYDDLLQLKNAISIASGNWLGKTYSYISMTKNVGYPLFLALTQLLNIPYSVLYGLLISLSSFSFIKAIQPVVKSKKLLLLIFFVIIFTPINHGAFYRIYRNALVPWVLLLIISSYIAIFIRRRDRLSLFLPWTILAFFSIMYFWTLREDSIWILPFILVAAITIIITIVILYKKDLHEILLRSVLVLLPLIGIVVSNVWVSAINYSYYGIWGVNDRSDTAAAKAMSLIYKIEDNQTTDSTVWASRKAFELAIKASPSLRTVGNTVLASYGLWAGKNTDIKGDIAQWAFRFGVEEEGYYHGNGKKTNALYKAIANELGEAFQKGRLKKRDGIYLSTQTGAFHWKDISQSMTMSLDLTNKMFHFYNTNLSSGYIDYPNLTETELISYEDMLNTSLPRTNDQLSAVGITKTYSDYDVNLTSLSNHYQQLNASIFRRRNYYINFQEKLIKCYQVVSYFMFPLSFLAYLILIIDGFRHQFTANNLSKLIILSSLLLTGILNLFIVSLFSRWIDPNTDSFIYGFYAPSAYLLFNLFMCMGGIVLFEKLCSSRMLKNFLSTVGNYMGRHRD","785419","","conserved hypothetical protein (possible membrane protein)","Membrane, Cytoplasm","Matches in gapped BLAST to membrane protein from Clostridium acetobutylicum : residues 1-495 are 21% similar to the protein in (gi|15894254|) and residues 8-494 are 23% similar to the protein in (gi|15894253|).SMu0759 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000463
Domain

Cytosolic fatty-acid binding
PS00214	$\"[31-48]?$	FABP

noIPR
unintegrated

unintegrated
signalp	$\"[1-30]?$	signal-peptide
tmhmm	$\"[10-28]?$ $\"[83-103]?$ $\"[115-135]?$ $\"[141-159]?$ $\"[168-186]?$ $\"[192-210]?$ $\"[225-247]?$ $\"[489-507]?$ $\"[522-542]?$ $\"[556-578]?$	transmembrane_regions

InterPro
IPR007921
Domain

Cysteine, histidine-dependent amidohydrolase/peptidase
PF05257	$\"[424-542]T$	CHAP
PS50911	$\"[419-542]T$	CHAP

InterPro
IPR009148
Family

Streptococcal non-M secreted SibA
PR01852	$\"[439-461]T$ $\"[464-488]T$ $\"[507-530]T$	SIBAPROTEIN

InterPro
IPR013688
Repeat

GBS Bsp-like
PF08481	$\"[32-126]T$ $\"[133-214]T$ $\"[219-312]T$ $\"[323-416]T$	GBS_Bsp-like

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 437-515 are 43% similar to a (PRECURSOR SIGNAL PLASMID SECRETED) protein domain (PD012961) which is seen in Q53587_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Apr 26 13:26:07 2002","Fri Apr 26 13:22:56 2002","Tue Jan 15 09:43:41 2002","Thu Dec 20 10:32:23 2001","","Thu Dec 20 10:32:23 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0760 is paralogously related (blast p-value < 1e-3) to SMu0630 ,a predicted hypothetical protein,SMu0555,a predicted 40K cell wall protein precursor (sr 5' region);choline bindingprotein D, SMu0332 and SMu0018,both predicted glucan-binding protein B;immunodominant glycoprotein IDG-60; general stress protein GSP-781,and finally SMu0176, a predicted immunogenic secreted protein (transfer protein).","Fri Apr 26 13:26:07 2002","","No significant hits to the NCBI PDB database.","SMU.836","","Residues 424 to 542 (E-value = 8.4e-34) place SMu0760 in the CHAP family which is described as CHAP domain (PF05257)","Thu Dec 20 10:32:23 2001","24379291","","Mattos-Graner,R.O., Jin,S., King,W.F., Chen,T., Smith,D.J. andDuncan,M.J.Cloning of the Streptococcus mutans Gene Encoding Glucan BindingProtein B and Analysis of Genetic Diversity and Protein Productionin Clinical IsolatesInfect. Immun. 69 (11), 6931-6941 (2001)PubMed: 11598068Chia,J.S., Lee,Y.Y., Huang,P.T. and Chen,J.Y. Identification of Stress-Responsive Genes in Streptococcus mutans by Differential Display Reverse Transcription-PCR Infect. Immun. 69 (4), 2493-2501 (2001) PubMed: 11254612 Chia,J.S., Chang,L.Y., Shun,C.T., Chang,Y.Y. and Chen,J.Y. A 60-Kilodalton Immunodominant Glycoprotein Is Essential for Cell Wall Integrity and the Maintenance of Cell Shape in Streptococcus mutans Infect. Immun. 69 (11), 6987-6998 (2001) PubMed: 11598074","Reinscheid,D.J., Gottschalk,B., Schubert,A., Eikmanns,B.J. andChhatwal,G.S.Identification and molecular analysis of PcsB, a protein requiredfor cell wall separation of group B streptococcusJ. Bacteriol. 183 (4), 1175-1183 (2001)PubMed: 11157929","Tue Jan 15 09:32:42 2002","Tue Jan 15 09:37:39 2002","1","","","SMU.836","" "SMu0761","787379","788221","843","ATGGAAGCGTACACTTTAATAAACGGCGTTCATATTCCTAAAATTGGTTTTGGAACTTGGAAATTGGCTGATGGGGATGAAGCTTATAAAAGCGTTAGTTATGCTCTTGAGGTTGGCTATAGACATGTTGATACAGCGCAGTATTATGGTAATGAAGTGAGTGTTGGCCGTGCCATTGCTGATAGTCCTATAAAGAGAGAAGAGCTTTTTATAACAACTAAAATTTGGAATGATAAGCATAGCTACGATGAGGCAAAACAATCTGTTGAAGAATCTCTCGCTAAGTTAAAACTTAATTATCTGGATTTGTTGCTTATTCATTGGCCTAATCCTAAAGCCTTGCGTGAAAATGATGCATGGAAGACAAGAAATGCTGACGTTTGGCGGGCAATGGAAGATTTATATCAGGCAGGGAAAGTCCGTGCTATCGGTGTCTCTAATTTTATGATTCATCATTTGGAGCCTTTGCTGGAAGTGGCTACTGTCAAGCCAATGGTCAATCAGGTTCTCTTGGCTCCCGGTTGTTCACAGGAGGAGCTGGTTGCTTTCTGCAGACAAAATGAGATGATCTTGGAGGCTTACAGTCCTCTAGGCACAGGAAGTATTTTCGATAATCAAACAGCTCAAGATTTAGCTAATAAGTATAATAAAACAGTAGCGCAAATTGCTTTACGTTGGTCATTGCAAAAGGGATTCTTACCCCTGCCTAAATCAGCAACACCTAAGAATATCCTATCGAATCTTGCTATTTTTGATTTTGATTTGACGGAAGACGATATCTTAAAGCTTGATAAAATTGAAAATGTCAAATCACAGGGCAATCCTGATGAAACTGCCTTTTAA","5.30","-6.63","31576","MEAYTLINGVHIPKIGFGTWKLADGDEAYKSVSYALEVGYRHVDTAQYYGNEVSVGRAIADSPIKREELFITTKIWNDKHSYDEAKQSVEESLAKLKLNYLDLLLIHWPNPKALRENDAWKTRNADVWRAMEDLYQAGKVRAIGVSNFMIHHLEPLLEVATVKPMVNQVLLAPGCSQEELVAFCRQNEMILEAYSPLGTGSIFDNQTAQDLANKYNKTVAQIALRWSLQKGFLPLPKSATPKNILSNLAIFDFDLTEDDILKLDKIENVKSQGNPDETAF","788220","","oxidoreductase, aldo/keto reductase family","Cytoplasm","Several matches in gapped BLAST to oxidoreductase: residues 1-259 are 56% similar to the enzyme in S.pneumoniae (gi15901328). Residues 6-280 are 53% similar to the protein from S.pyogenes (gi15675551).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1476 (1e-105).","

InterPro
IPR001395
Family

Aldo/keto reductase
PD000288	$\"[12-260]T$	Aldo/ket_red
PR00069	$\"[35-59]T$ $\"[91-109]T$ $\"[131-148]T$ $\"[165-194]T$ $\"[202-226]T$	ALDKETRDTASE
G3DSA:3.20.20.100	$\"[4-266]T$	Aldo/ket_red
PTHR11732	$\"[5-239]T$	Aldo/ket_red
PF00248	$\"[6-268]T$	Aldo_ket_red
PS00062	$\"[131-148]T$	ALDOKETO_REDUCTASE_2
PS00798	$\"[39-56]T$	ALDOKETO_REDUCTASE_1

noIPR
unintegrated

unintegrated
PTHR11732:SF34	$\"[5-239]T$	PTHR11732:SF34
SSF51430	$\"[1-266]T$	SSF51430

","BeTs to 7 clades of COG0656COG name: Aldo/keto reductases, related to diketogulonate reductaseFunctional Class: RThe phylogenetic pattern of COG0656 is ---kY-VcEBr----------Number of proteins in this genome belonging to this COG is 3","***** IPB001395 (Aldo/keto reductase family) with a combined E-value of 2.1e-70. IPB001395A 6-17 IPB001395B 35-54 IPB001395C 64-76 IPB001395D 98-109 IPB001395E 161-198 IPB001395F 215-260","Residues 12-266 are 55% similar to a (OXIDOREDUCTASE PROTEOME CHANNEL COMPLETE DEHYDROGENASE) protein domain (PD000288) which is seen in Q9CIT8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 15 11:23:45 2002","Thu Sep 14 14:07:50 2006","Thu Sep 14 14:07:50 2006","Thu Dec 20 10:48:05 2001","Thu Dec 20 10:48:05 2001","Thu Dec 20 10:48:05 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0761 is paralogously related (blast p-value < 1e-3) to SMu0621,SMu0620, and SMu0345, all predicted oxidoreductases, aldo/keto reductase family.","Tue Jan 15 11:23:45 2002","Thu Sep 14 14:07:50 2006","pdb1A80 Native 2,5-Diketo-D-Gluconic Acid Reductase A From... 201 8e-053pdb1AE4 Aldehyde Reductase Complexed With Cofactor And Inhi... 188 8e-049pdb1CWN Crystal Structure Of Porcine Aldehyde Reductase Ho... 188 8e-049","SMU.837","","Residues 6 to 268 (E-value = 1e-113) place SMu0761 in the Aldo_ket_red family which is described as Aldo/keto reductase family (PF00248)","Thu Dec 20 10:48:05 2001","24379292","","","Samaras,N. and Spithill,T.W.The developmentally regulated P100/11E gene of Leishmania majorshows homology to a superfamily of reductase genesJ. Biol. Chem. 264 (7), 4251-4254 (1989)PubMed: 2918000","","Thu Dec 20 10:50:40 2001","1","","","SMU.837","423" "SMu0762","788354","789706","1353","ATGACTAAACAATATGATTATATCGTTATTGGTGGTGGTTCAGGCGGGATTGCCTCTGCTAACCGCGCGGCTATGCATGGGGCTAAGGTGATTCTGTTTGAAGGCAAGCAAGTCGGTGGAACCTGTGTTAATGTTGGCTGTGTTCCTAAGAAAGTCATGTGGTATGGAGCTCAAGTAGCAGAAACCATTAATAATTATGCAGCTGACTACGGTTTTGATGTAACAACTCAGGCCTTTCATTTCGATGTCTTGAAGCAAAATCGTCAGGCTTATATTGATCGTATTCATGATTCTTATGAACGTGGTTTTGATAGCAATGGTGTTGAACGTGTTTATGGCTATGCTACTTTTGTAGATGCTCATACAGTAGAAGTAGCTGGGGAACATTATACTGCACCGCATATTTTGATTGCGACGGGTGGTCATGCCTTACTGCCGGATATTCCTGGTAGTGAGTATGGTATTACTTCAGATGGCTTCTTTGAGTTAGATGCCATTCCTAAACGGACAGCAGTTGTTGGTGCTGGTTATATTGCTGTGGAAATTTCAGGTATTCTGCATGCTCTTGGCAGTGAGACACATCTTTTTGTCCGTCGGGATCGTCCCCTTCGCAAATTTGATAAGGAAATTGTTGGAACACTTGTGGACGAAATGAAAAAGGATGGTCCTCATCTTCATACTTTTTCAGTCCCTAAAGAAGTGATTAAAAATACTGATAATAGTCTAACACTTATTTTGGAAAATGGTGAGGAGTACACTGTTGATACATTGATTTGGGCAATTGGCCGTGCTGCCAATACAAAAGGTTTTAATCTGGAAGTGACTGGTGTCACATTAGATAGTAGAGGTTTTATTGCGACTGATGCATTTGAAAATACTAATGTTGAAGGTTTGTATGCTCTTGGAGATGTCAATGGAAAATTAGAATTAACACCAGTTGCTGTAAAGGCTGGCCGTCAACTGTCTGAACGCCTTTTTAACCATAAGCCTCAGGCTAAGATGGATTATAAGGATGTTGCTACCGTTATTTTCAGCCATCCAGTTATTGGTTCAATCGGCCTATCTGAAGAGGCGGCTTTAGATCAGTATGGTGAAGAAAATGTCACCGTTTATCGTTCAACTTTTACTTCAATGTATACGGCAGTAACCAGTCACCGTCAAGCTTGCAAGATGAAGTTGGTAACAGTAGGTGAGGATGAAAAGATTGTTGGTCTACATGGTATTGGTTATGGTGTTGATGAGATGATTCAAGGTTTTGCGGTTGCTATCAAAATGGGAGCAACTAAGGCTGATTTTGACAATACCGTTGCCATTCACCCAACAGGTTCAGAAGAGTTTGTCACTATGCGCTGA","5.60","-12.26","48967","MTKQYDYIVIGGGSGGIASANRAAMHGAKVILFEGKQVGGTCVNVGCVPKKVMWYGAQVAETINNYAADYGFDVTTQAFHFDVLKQNRQAYIDRIHDSYERGFDSNGVERVYGYATFVDAHTVEVAGEHYTAPHILIATGGHALLPDIPGSEYGITSDGFFELDAIPKRTAVVGAGYIAVEISGILHALGSETHLFVRRDRPLRKFDKEIVGTLVDEMKKDGPHLHTFSVPKEVIKNTDNSLTLILENGEEYTVDTLIWAIGRAANTKGFNLEVTGVTLDSRGFIATDAFENTNVEGLYALGDVNGKLELTPVAVKAGRQLSERLFNHKPQAKMDYKDVATVIFSHPVIGSIGLSEEAALDQYGEENVTVYRSTFTSMYTAVTSHRQACKMKLVTVGEDEKIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR","789705","This enzyme maintains a high level of reduced glutathione in the cytosol [gi:8928150]. ","glutathione reductase","Cytoplasm","Matches in gapped BLAST to glutathione reductase:residues 1-450 are 96% similar to the previously published enzyme in S.mutans (gi4587160).Residues 1-450 are 71% similar to glutathione reductase in S.pyogenes (gi15674854)The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1375 (1e-161).","

InterPro
IPR000815
Family

Mercuric reductase
PR00945	$\"[16-34]T$ $\"[136-153]T$ $\"[189-204]T$	HGRDTASE

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[6-28]T$ $\"[38-53]T$ $\"[135-144]T$ $\"[169-194]T$ $\"[255-269]T$ $\"[298-305]T$ $\"[335-356]T$ $\"[402-417]T$ $\"[424-444]T$	PNDRDTASEI

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[139-209]T$	FAD_pyr_redox
PF00070	$\"[169-262]T$	Pyr_redox

InterPro
IPR004099
Domain

Pyridine nucleotide-disulphide oxidoreductase dimerisation region
G3DSA:3.30.390.30	$\"[338-450]T$	Pyr_redox_dim
PF02852	$\"[339-450]T$	Pyr_redox_dim

InterPro
IPR006322
Family

Glutathione reductase, animal and bacterial
TIGR01421	$\"[3-450]T$	gluta_reduc_1

InterPro
IPR012999
Active_site

Pyridine nucleotide-disulphide oxidoreductase, class I, active site
PS00076	$\"[39-49]T$	PYRIDINE_REDOX_1

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[6-28]T$ $\"[135-144]T$ $\"[169-194]T$ $\"[255-269]T$ $\"[298-305]T$	FADPNR
PF07992	$\"[6-308]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[3-335]T$	G3DSA:3.50.50.60
PTHR22912	$\"[8-450]T$	PTHR22912
PTHR22912:SF27	$\"[8-450]T$	PTHR22912:SF27
SSF51905	$\"[4-299]T$	SSF51905
SSF55424	$\"[336-450]T$	SSF55424

","BeTs to 12 clades of COG1249COG name: Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymesFunctional Class: CThe phylogenetic pattern of COG1249 is amt-YqvCEBRH--gp--inXNumber of proteins in this genome belonging to this COG is 4","***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 2.2e-32. PR00368A 6-28 PR00368B 135-144 PR00368C 169-194 PR00368D 255-269 PR00368E 298-305***** IPB001100 (Pyridine nucleotide-disulphide oxidoreductase, class I) with a combined E-value of 5.8e-10. IPB001100 39-53***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 2.2e-09. IPB000103A 6-26 IPB000103B 39-53 IPB000103D 256-267 IPB000103E 293-330***** IPB000172 (Glucose-methanol-choline (GMC) oxidoreductase) with a combined E-value of 1.9e-08. IPB000172A 5-32***** IPB000171 (Bacterial-type phytoene dehydrogenase) with a combined E-value of 2.7e-07. IPB000171A 8-38 IPB000171A 171-201","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 13:30:45 2002","Thu Dec 20 10:52:09 2001","Wed Sep 27 13:10:34 2006","Thu Dec 20 10:52:09 2001","Thu Dec 20 10:52:09 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0762 is paralogously related (blast p-value < 1e-3) to SMu0116, and SMu1299,both dihydrolipoamide dehydrogenases, SMu0126, a predicted glutathione reductase, SMu0420,a predicted NADH oxidase, SMu0792, a predicted thioredoxin reductase, SMu1020,a predicted H2O-forming NADH oxidase, SMu0693,a predicted NADH oxidase/alkyl hydroperoxidase reductase, SMu0331, a predicted glutamate synthase small subunit, and SMu1286, a predicted fumarate reductase.","Wed Mar 20 14:28:08 2002","Wed Sep 27 13:10:34 2006","pdb1GERB Chain B, Glutathione Reductase (E.C.1.6.4.2) Complex... 577 8e-166pdb1GESB Chain B, Glutathione Reductase (E.C.1.6.4.2) Nad Mut... 569 3e-163pdb1XAN Human Glutathione Reductase In Complex With A Xant... 437 2e-123","SMU.838","","Residues 6 to 313 (E-value = 1.5e-87) place SMu0762 in the Pyr_redox family which is described as Pyridine nucleotide-disulphide oxidoreductase (PF00070)Residues 339 to 450 (E-value = 1.9e-50) place SMu0762 in the Pyr_redox_dim family which is described as Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (PF02852)","Wed Sep 27 13:10:34 2006","24379293","","","Pebay,M., Holl,A.C., Simonet,J.M. and Decaris,B.Characterization of the gor gene of the lactic acid bacteriumStreptococcus thermophilus CNRZ368Res. Microbiol. 146 (5), 371-383 (1995)PubMed: 8525054Greer,S. and Perham,R.N.Glutathione reductase from Escherichia coli: cloning and sequenceanalysis of the gene and relationship to other flavoproteindisulfide oxidoreductasesBiochemistry 25 (9), 2736-2742 (1986)PubMed: 3521741Ermler,U. and Schulz,G.E.The three-dimensional structure of glutathione reductase fromEscherichia coli at 3.0 A resolutionProteins 9 (3), 174-179 (1991)PubMed: 2006135Mittl,P.R. and Schulz,G.E.Structure of glutathione reductase from Escherichia coli at 1.86 Aresolution: comparison with the enzyme from human erythrocytesProtein Sci. 3 (5), 799-809 (1994)PubMed: 8061609","Wed Sep 27 13:10:34 2006","Thu Dec 20 10:59:41 2001","1","","","SMU.838","412" "SMu0763","790982","789726","1257","ATGAATAAAACAGAAACGCTCAATTGGATTCACTCCTTTAAAGCCAAGGGACGACAAGCTGATTTAAAACGCATGAATTGGCTCTTAGAAAAATTAGGCAAGCCACAAACTACATTTCCTGCTATTCACATTGTTGGAACCAATGGTAAAGGATCTACATGTAGCTATTTACAGCATATTCTGACAGCATCAGGCTATAAAACGGGAAGCTTTACTTCTCCTTATATTACTCGCTTTAATGAACGTATTGCCATTGACGGGAAGGAAATTTCTGATCAGGACTTAAACAAGGTCATTTCGCTTGTCAAACCCATTGTTGAATCAGTAACCGTTGAAACCCATTATGAAAAAGTCACCGAATTTGAACTCGTCACACTTCTTATGTTTACCTATTTTGCACAAATCAATCCTGTAGACATTGCCATCATTGAAGCAGGAATCGGTGGACTTAAGGATTCAACAAACGTTTTCAAAGCATTGGCGGTTGTCTGTCCTTCAATAAGTTTTGATCATCAAGAAAAACTGGGAAATAGTTTAGCACAAATTGCCCGGCAAAAGGTAGGAGTCTTAGATGAAAAGGTCCCCTTTATTTTTGGCCAAATGACTTCTGCAGTTAAACAAGTGTTTTATGAAGAAACCCAATTATTAGGCTGCCCAACTTTTGAATGCAATAAAGACTTTTCTTTTAAGGAAAATGGCAAAGTTTTTGACTTTATTTATCAAGACTTTTTGATATCAGCTATTCACCTAAAAATGTTAGGACAACACCAAAAAGCTAATGCCAGTCTTGCCATTATGACGAGTTTAATTCTAGCTAAGGTATTTCCAAATATTAATTCCAAAACAATAAGGACTGGTCTTCAATCCACCATCTGGCCTGGACGTTGTGAACTATTACAAGCTAATTTGCTGCTTGATGGCGCCCACAATATAGATGCTATTACAAAGCTGATTCAAGTGCTAAAAGACAGCTTTAGAGATAAAACCATTCATATTCTCTTTGCCGGGCTCAAACGTAAACCAATCGAAAAAATGTTAGCACAATTAGCTGAATTTGATCTCAGTGTTACGAGCTTTGATTTTTTTGAAGCCTTGCCTTTAGAAAATTACCCACTTAGCTATCCAAGAGTTGACAATTGGAAAAATTGGATAACTCAGGCAACAGCCCATTCAGACCATCTTTATGTTGTAACAGGATCTTTCTACTTCATTTCCCAAGTTCGTAATCACCTAATCGAAAAGACAAGGCTCCAATGA","8.60","6.67","47226","MNKTETLNWIHSFKAKGRQADLKRMNWLLEKLGKPQTTFPAIHIVGTNGKGSTCSYLQHILTASGYKTGSFTSPYITRFNERIAIDGKEISDQDLNKVISLVKPIVESVTVETHYEKVTEFELVTLLMFTYFAQINPVDIAIIEAGIGGLKDSTNVFKALAVVCPSISFDHQEKLGNSLAQIARQKVGVLDEKVPFIFGQMTSAVKQVFYEETQLLGCPTFECNKDFSFKENGKVFDFIYQDFLISAIHLKMLGQHQKANASLAIMTSLILAKVFPNINSKTIRTGLQSTIWPGRCELLQANLLLDGAHNIDAITKLIQVLKDSFRDKTIHILFAGLKRKPIEKMLAQLAEFDLSVTSFDFFEALPLENYPLSYPRVDNWKNWITQATAHSDHLYVVTGSFYFISQVRNHLIEKTRLQ","789731","For other 'fol' genes see SMu0521 (folD); SMu0878 (folC);SMu0879 (folE); SMu0880 (folP); SMu0881 (folA) (folQ) and SMu0882 (folK). ","folyl-polyglutamate synthetase/ dihydrofolate synthase","Cytoplasm","Several matches in gapped BLAST to folyl-polyglutamate synthetase: residues 1-417 are 55% similar to the enzyme in S.pyogenes (gi15674855).Residues 1-414 are 42% similar to the enzyme in S.suis (gi13345177) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1117 (1e-114).","

InterPro
IPR001645
Family

Folylpolyglutamate synthetase
TIGR01499	$\"[22-411]T$	folC

InterPro
IPR004101
Domain

Cytoplasmic peptidoglycan synthetases, C-terminal
PF02875	$\"[292-367]T$	Mur_ligase_C

InterPro
IPR013221
Domain

Mur ligase, middle region
PF08245	$\"[42-268]T$	Mur_ligase_M

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.10	$\"[4-293]T$	G3DSA:3.40.1190.10
G3DSA:3.90.190.20	$\"[294-411]T$	G3DSA:3.90.190.20
PTHR11136	$\"[26-352]T$	PTHR11136
SSF53244	$\"[292-413]T$	SSF53244
SSF53623	$\"[1-291]T$	SSF53623

","BeTs to 10 clades of COG0285COG name: Folylpolyglutamate synthaseFunctional Class: HThe phylogenetic pattern of COG0285 is ----Yqvcebrhuj---l--xNumber of proteins in this genome belonging to this COG is 2","***** IPB001645 (Folylpolyglutamate synthetase) with a combined E-value of 3.2e-45. IPB001645A 41-65 IPB001645B 68-88 IPB001645C 122-157 IPB001645D 162-195 IPB001645E 395-408","Residues 252-414 are 30% similar to a (SYNTHETASE PROTEOME DIHYDROFOLATE) protein domain (PD122331) which is seen in Q54614_STRPN.Residues 231-411 are 36% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE PROTEOME) protein domain (PD122334) which is seen in Q9CGE0_LACLA.Residues 17-219 are 27% similar to a (FPGS ATP-BINDING SYNTHASE SYNTHETASE) protein domain (PD321109) which is seen in FOLC_YEAST.Residues 129-190 are 50% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE SYNTHETASE) protein domain (PD003937) which is seen in Q9CBY8_MYCLE.Residues 42-127 are 39% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE COMPLETE) protein domain (PD403087) which is seen in Q9CGE0_LACLA.Residues 42-112 are 40% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE PROTEOME) protein domain (PD413942) which is seen in O08416_STRCO.Residues 22-126 are 45% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE SYNTHETASE) protein domain (PD164066) which is seen in Q9K8G9_BACHD.Residues 22-124 are 39% similar to a (RELATED TETRAHYDROFOLYLPOLYGLUTAMATE) protein domain (PD394331) which is seen in Q9HEK9_NEUCR.Residues 121-221 are 34% similar to a (SYNTHETASE PROTEOME FOLYL-POLYGLUTAMATE) protein domain (PD358647) which is seen in Q9RXH3_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 22 13:10:13 2007","Thu Feb 22 13:10:13 2007","Thu Feb 22 13:10:13 2007","Thu Dec 20 11:04:37 2001","Thu Dec 20 11:04:37 2001","Thu Dec 20 11:04:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0763 is paralogously related (blast p-value < 1e-3) to SMu0878, a predicted folyl-polyglutamate synthetase and SMu1529, a predicted UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate ligase.","Thu Jan 24 13:47:14 2002","Thu Feb 22 13:10:13 2007","pdb1FGS Folylpolyglutamate Synthetase From Lactobacillus C... 226 5e-060","SMU.839c","","Residues 8 to 284 (E-value = 1.1e-07) place SMu0763 in the Mur_ligase family which is described as Mur ligase family, catalytic domain (PF01225)Residues 292 to 369 (E-value = 3.8e-06) place SMu0763 in the Mur_ligase_C family which is described as Mur ligase family, glutamate ligase domain (PF02875)","Thu Feb 22 13:10:13 2007","","","","Swedberg,G., Ringertz,S. and Skold,O.Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomaldihydropteroate synthaseAntimicrob. Agents Chemother. 42 (5), 1062-1067 (1998)PubMed: 9593127Smith,H.E., Buijs,H., Wisselink,H.J., Stockhofe-Zurwieden,N. andSmits,M.A.Selection of Virulence-Associated Determinants of Streptococcussuis Serotype 2 by In Vivo ComplementationInfect. Immun. 69 (3), 1961-1966 (2001)Pubmed:11179384","","Thu Dec 20 11:08:13 2001","1","","","SMU.839c","" "SMu0764","791768","791322","447","ATGGCAAATAACTATTCTCGTCGTCAACAACCCACTAAAAAAACAAAGGGGACAAGTCGGAAACGTCCGACTGAACATATCAAAACAGGTTTTTCAGCACTGCAAAAGAGTGTTGCTATTATCGCTGGTATTTTAGGGATTATTACCGCTTTGATTACTATTAATAATTATCGCAATAGTTCACACAATGATAAAAAAGATTCCACATCTAAAACCACTATCATCAAAGAAAAAGAAGTGGATGACTCAAATAGTAACAACAATGCTGCTAATTCTCAAGCTGAAAATGACAGCAATAACAATAATAATTCTGCAGAATCAAATCAAAACCAAACTGCAACAACAGCAAATGACAGTAACAGCAATTCGGCTAATCAAAATCAAGCCAATAGCCAATCACAAGCAAATAATCAGCAAAATCAAAACAATGCTAATGCTGGTCAATAA","10.50","5.47","15994","MANNYSRRQQPTKKTKGTSRKRPTEHIKTGFSALQKSVAIIAGILGIITALITINNYRNSSHNDKKDSTSKTTIIKEKEVDDSNSNNNAANSQAENDSNNNNNSAESNQNQTATTANDSNSNSANQNQANSQSQANNQQNQNNANAGQ","791327","","hypothetical protein","Extracellular, Membrane, Cytoplasm","No significant hits in gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1374 (2e-07).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[37-57]?$	transmembrane_regions

InterPro
IPR000192
Family

Aminotransferase, class V
PF00266	$\"[2-365]T$	Aminotran_5
PS00595	$\"[193-212]T$	AA_TRANSFER_CLASS_5

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[2-256]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[1-375]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PIRSF005572	$\"[1-380]T$	NifS
PTHR11601	$\"[1-380]T$	PTHR11601

","BeTs to 12 clades of COG1104COG name: Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes (NifS family)Functional Class: EThe phylogenetic pattern of COG1104 is A--kYQvCeBRHuj---lINXNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 50-215 are 69% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9CI29_LACLA.Residues 340-379 are 60% similar to a (AMINOTRANSFERASE PROTEOME COMPLETE) protein domain (PD375301) which is seen in Q9CI29_LACLA.Residues 38-106 are 42% similar to a (AMINOTRANSFERASE PROTEOME PYRIDOXAL LYASE) protein domain (PD311278) which is seen in ISCS_PSEAE.Residues 292-338 are 78% similar to a (LYASE PYRIDOXAL DESULFURASE PHOSPHATE 4.4.1.- CYSTEINE) protein domain (PD189309) which is seen in Q9CI29_LACLA.Residues 2-35 are 70% similar to a (LYASE CYSTEINE DESULFURASE 4.4.1.-) protein domain (PD351786) which is seen in Q9CI29_LACLA.Residues 108-208 are 39% similar to a (AMINOTRANSFERASE V PROTEOME COMPLETE) protein domain (PD393971) which is seen in Q9RXU1_DEIRA.Residues 220-254 are 71% similar to a (LYASE PHOSPHATE 4.4.1.- PYRIDOXAL DESULFURASE CYSTEINE) protein domain (PD001054) which is seen in Q9CI29_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:31:53 2002","Thu Sep 14 09:56:56 2006","Thu Sep 14 09:56:56 2006","Thu Dec 20 11:12:49 2001","","Thu Dec 20 11:12:49 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0765 is paralogously related (blast p-value < 1e-3) to SMu0959, a predicted iron-sulfur cofactor synthesis protein and SMu0226, a predicted NifS protein homolog, class-V aminotransferase.","Thu Jan 24 14:04:16 2002","Thu Sep 14 09:56:56 2006","pdb1ECXB Chain B, Nifs-Like Protein >gi7546479pdb1ECXA Ch... 265 9e-072pdb1EG5B Chain B, Nifs-Like Protein >gi7546280pdb1EG5A Ch... 256 3e-069pdb1C0NA Chain A, Csdb Protein, Nifs Homologue 76 9e-015","SMU.841","","Residues 10 to 365 (E-value = 1.4e-84) place SMu0765 in the Aminotran_5 family which is described as Aminotransferase class-V (PF00266)","Thu Dec 20 11:12:49 2001","24379296","","","Leong-Morgenthaler,P., Oliver,S.G., Hottinger,H. and Soll,D.A Lactobacillus nifS-like gene suppresses an Escherichia colitransaminase B mutationBiochimie 76 (1), 45-49 (1994)PubMed: 8031904","","Thu Dec 20 11:23:48 2001","1","","","SMU.841","411" "SMu0766","793149","794366","1218","ATGCAGTATTCAGAAATTATGGTGCGTTATGGTGAATTGTCAACGAAAGGTAAAAATCGTATGCGTTTTATCAATCAATTGAAACGCAATATGAAACATGTTTTGTCCATTTATCCTGAAGTCAGTATTCGTGCGGATCGTGATCGTGCCCATATCTATCTTAATGGAGCAAACTATGTTCCTGTAGCAGAATCCCTTAAACAAATTTTTGGGATTCAAGCCTTCTCTCCCTCCTATAAGGTTGAAAAAAGTGTCCCTGCTTTAGAGAAGGCTGTTCAAGCAATTATGGTGGAACTTCATCATGAAGGTTTGACATTTAAAATTTCCAGCAAAAGAAGTGATCATCAGTTTGAATTAGACAGTCGTGAACTTAATCAGGTTTTGGGCAGTGCAGTTTTTGCCGTTTTGCCTGATATCAAAGCGCAGATGAATCATCCAAATGTCAATTTGAAAGTAGAGATTCGTGAGGAAGCAGCTTATCTTTCTTATGAAAATATTAAAGGAGCGGGTGGTTTGCCTGTTGGTACAGCAGGTAAGGGTATGCTGATGCTGTCAGGAGGAATTGATTCACCAGTGGCGGGCTATCTTGCTCTAAAAAGAGGCGTTAATATTGAAGCAGTTCATTTTGCCAGTCCGCCTTATACTAGCCCCGGTGCTCTGAAAAAAGCACAGGATTTGACACGTAAATTGACTAAATTTGGCGGCAATATTCAATTTATTGAAGTGCCTTTTACAGAGATTCAGGAAGAAATTAAGGCAAAAGCTCCTGAAGCCTATCTAATGACCTTAACTCGGCGTTTCATGATGCGAATTGCCGATCGGATTCGAGAAGAGCGCAGTGGTTTAGTTATTATCAATGGTGAGAGTCTGGGACAGGTTGCCAGTCAGACATTAGAGTCTATGCAAGCTATCAATGCTGTTACGACAACACCTGTTATTCGACCTGTGGTCACCATGGATAAATTGGAAATTATTGATATTGCTGAGAAGATTGATACTTTTGCTATTTCGATTCAGCCTTTTGAAGATTGTTGTACTATTTTTGCACCGGATCGGCCTAAAACCAATCCTAAAATTAAGAATGTGGAGCAGTATGAAGCGAGGTTAGATATTGAAGGTTTGGTTGCGCGTGCTGTAGCGGGCATCAACATTACAGAAATAACACCGCAGGAAGAAAGTCAGGATGAAGTTGATGTCTTAATCGAAGATTTATTGTAA","6.40","-2.37","45093","MQYSEIMVRYGELSTKGKNRMRFINQLKRNMKHVLSIYPEVSIRADRDRAHIYLNGANYVPVAESLKQIFGIQAFSPSYKVEKSVPALEKAVQAIMVELHHEGLTFKISSKRSDHQFELDSRELNQVLGSAVFAVLPDIKAQMNHPNVNLKVEIREEAAYLSYENIKGAGGLPVGTAGKGMLMLSGGIDSPVAGYLALKRGVNIEAVHFASPPYTSPGALKKAQDLTRKLTKFGGNIQFIEVPFTEIQEEIKAKAPEAYLMTLTRRFMMRIADRIREERSGLVIINGESLGQVASQTLESMQAINAVTTTPVIRPVVTMDKLEIIDIAEKIDTFAISIQPFEDCCTIFAPDRPKTNPKIKNVEQYEARLDIEGLVARAVAGINITEITPQEESQDEVDVLIEDLL","794365","For other 'thi' genes see SMu0077 (thiD).From Genbank: [gi:3915122]This protein is required for the synthesis of the thiazole moiety.","thiamine biosynthesis protein","Cytoplasm","Several matches in gapped BLAST to thiamin biosynthesis protein: residues 1-405 are 80% similar to the protein in S.pneumoniae (gi|15902828|) and are 74% similar to the protein from S.pyogenes (gi|15674858|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1372 (0.0).","

InterPro
IPR003720
Family

Thiamine biosynthesis protein
PF02568	$\"[175-371]T$	ThiI
TIGR00342	$\"[6-376]T$	ThiI

InterPro
IPR004114
Domain

THUMP
PF02926	$\"[73-165]T$	THUMP
PS51165	$\"[60-165]T$	THUMP

noIPR
unintegrated

unintegrated
SSF52402	$\"[177-332]T$	SSF52402

","BeTs to 9 clades of COG0301COG name: Enzyme of thiamine biosynthesis (ThiI); contains a PP-loop superfamily ATPase domain and an uncharacterized conserved domainFunctional Class: HThe phylogenetic pattern of COG0301 is amtK--v-eb-h--gp-l---Number of proteins in this genome belonging to this COG is 1","***** IPB003720 (Thiamine biosynthesis protein (ThiI)) with a combined E-value of 1.9e-54. IPB003720A 20-31 IPB003720C 168-201 IPB003720D 268-321","Residues 184-226 are 95% similar to a (BIOSYNTHESIS THIAMINE PROTEOME COMPLETE) protein domain (PD021940) which is seen in Q9CII1_LACLA.Residues 23-178 are 56% similar to a (BIOSYNTHESIS THIAMINE COMPLETE PROTEOME) protein domain (PD004096) which is seen in Q9CII1_LACLA.Residues 181-222 are 54% similar to a (BIOSYNTHESIS THIAMINE PROTEOME COMPLETE) protein domain (PD410962) which is seen in Q9PQ71_UREPA.Residues 268-375 are 66% similar to a (BIOSYNTHESIS THIAMINE COMPLETE PROTEOME) protein domain (PD006698) which is seen in Q9CII1_LACLA.Residues 179-256 are 47% similar to a (THIAMINE BIOSYNTHESIS THII) protein domain (PD391394) which is seen in THII_TREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:34:35 2002","Wed Apr 24 14:44:21 2002","Sat Oct 12 11:34:35 2002","Thu Dec 20 11:28:35 2001","Thu Dec 20 11:28:35 2001","Thu Dec 20 11:28:35 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0766 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 11:30:47 2001","","No significant hits to the NCBI PDB database.","SMU.842","","Residues 73 to 165 (E-value = 6.2e-08) place SMu0766 in the THUMP family which is described as THUMP domain (PF02926)Residues 175 to 371 (E-value = 1.5e-93) place SMu0766 in the ThiI family which is described as Thiamine biosynthesis protein (ThiI) (PF02568)","Thu Dec 20 11:28:35 2001","24379297","","","Webb,E., Claas,K. and Downs,D.M.Characterization of thiI, a new gene involved in thiazolebiosynthesis in Salmonella typhimuriumJ. Bacteriol. 179 (13), 4399-4402 (1997)PubMed: 9209060","","Wed Mar 20 14:43:08 2002","1","","","SMU.842","145" "SMu0767","794504","795685","1182","ATGATTAAGAAGACGAGAGATACGAAACTCATAGTAATTTGTTTAGCTTTCGTTCTTTTCTGTTTGTTGCTGGCTGGCATTCATGATTTGTTTTCAAGGACAAAGCAAATAGACACATCATCAAACGGAGTCCAAAGAGCAAGAGTTGTGGCTAATGGTGATATTCTTTATCATGATATTCTCTATACCAGTGCCAGAAAAAACGATGGTTCCTATGATTTTGACCCTTATTTTGAATATGTTAAAAGTTGGATTTCTAGCGCTGATTTGGCTATTGGTGATTTTGAAGGAACCATTAGTCCTGATTATCCTTTAGCGGGTTATCCTCTTTTCAATGCCCCGACTGAAGCTGCTCAATCAATGAAAGATACAGGTTATGATGTCGTTGATTTGGCTCATAATCATATTCTTGACTCTCAGCTTTCGGGTGCTTTAAATACGGTTAAGACCTTTAATGACTTAGGATTAGATACGATTGGTATTTACAAAGAAGATCGTGCTAAAGAATCTTTTCTAATTAAGAAAGTCAACGGCATTAAAATTGCTATCTTGGGCTATGCTTATGGTTACAATGGGATGGAAAGCAATTTAACAGAAGAAGAGCAGGCCGCTCACCTTTCTAACCTTGACGAAAAGAAAATAAAAGCAGAACTCAAAAGTGCTGAGAAAAAAGCTGATGTGACCATTGTCATGCCGCAAATGGGGACGGAGTATGCTCTTGAGCCAACAGAGGAACAAAAAACACTCTATCATAAAATGATCAAATGGGGAGCGGATGTCATTTTTGGTGGACATCCTCATGTTGCTGAACCATCAGAGGTTGTCAAGCAAGACGGACAGAAGAAGTTTATCATTTATTCCATGGGCAATTTTATTTCTAACCAGTCCTATGAGAATTTACAAAATTATTGGACGGAACGTGGCTTGCTCATGGATGTCACTTTTGAAAAGAAAGCTGGCAAAACAAATATTAAAACGGTTAAAGCCCATCCAACCATGGTCTGGTCTTGGGGCAAGGGGCAAACAGGTTCAGAAGGTTATGAGTATAAGGATTACCGAGTCTTGATTTTAGAAGATTTTATCGAAGGCGGCAAATATCGTCATAAATTAGATAGTGCCATGAAAGAGAAGGTTGATACAGCCTATAAAGAAATGAAGGAATTGGTGAATTTAAAATGGTAG","6.20","-4.66","44427","MIKKTRDTKLIVICLAFVLFCLLLAGIHDLFSRTKQIDTSSNGVQRARVVANGDILYHDILYTSARKNDGSYDFDPYFEYVKSWISSADLAIGDFEGTISPDYPLAGYPLFNAPTEAAQSMKDTGYDVVDLAHNHILDSQLSGALNTVKTFNDLGLDTIGIYKEDRAKESFLIKKVNGIKIAILGYAYGYNGMESNLTEEEQAAHLSNLDEKKIKAELKSAEKKADVTIVMPQMGTEYALEPTEEQKTLYHKMIKWGADVIFGGHPHVAEPSEVVKQDGQKKFIIYSMGNFISNQSYENLQNYWTERGLLMDVTFEKKAGKTNIKTVKAHPTMVWSWGKGQTGSEGYEYKDYRVLILEDFIEGGKYRHKLDSAMKEKVDTAYKEMKELVNLKW","795684","","; possible capsule biosynthesis protein CapA","Cytoplasm, Membrane, Extracellular","Several matches in gapped BLAST to hypothetical proteins: residues 44-393 are 73% similar to the protein in S.pyogenes (gi15674859). Residues 120-286 are 57% similar to the protein from S.pneumoniae (gi15901303).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1371 (1e-149).","

noIPR
unintegrated

unintegrated
SSF56300	$\"[171-285]T$	SSF56300

","BeTs to 3 clades of COG0737COG name: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterasesFunctional Class: FThe phylogenetic pattern of COG0737 is a-t-yqvCEB-Huj---l---Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 112-297 are 31% similar to a (PLASMID PROTEOME COMPLETE CAPA) protein domain (PD010034) which is seen in Q9RMX6_BACAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 10:22:27 2006","Tue Aug 1 10:22:27 2006","Tue Aug 1 10:22:27 2006","Tue Aug 1 10:22:27 2006","","Thu Dec 20 13:17:55 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0767 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 14:05:24 2002","","No significant hits to the NCBI PDB database.","SMU.843","","No significant hits to the Pfam 11.0 database","Thu Dec 20 13:17:55 2001","24379298","","","","","","1","","","SMU.843","697" "SMu0768","795716","796246","531","ATGACTTTAACTCAACAAAAAGTGAAGTTTTTTAGTAAAGCTTATCATGATGTTAAAAGATTATATCTTTCAGCTTTTCCACCTCGTGAGCGCTTTCCTTATTTTTGCTTGCTGCTAAATAGCTTGCGCTCTCTGGTGACTTGCTATGCCTATTATGATAAGGAACGCTTTGTTGGTTTTGCTTATATTATTGAATCTAAGGAGCAGGTGTTTATCCTTTTTTTAGCTGTTAATGGGTCAGTTCGCTCCAAAGGATATGGCAGTATGATATTAGCACAGATTCGTGAATATGCTGGAAGAAAACCGCTTATTTTAACGATAGAGCCTGTCGAGAAAGATTCGCCAAATAGTGAACAAAGAAGACAGCGGCTGTCCTTTTATGAGCGCAATGGATACCAACTGACATCTCATTACTATTACGAGGGGCAGGAGCGCTACCAGATATTGACTACGGAACAGAGTATTGATTTAGAACGTTTTCAAAAATTAGTCAAAAGAGCGGTTCTGGGCTTAGTGCTAATAACAGTATAG","10.30","9.38","20815","MTLTQQKVKFFSKAYHDVKRLYLSAFPPRERFPYFCLLLNSLRSLVTCYAYYDKERFVGFAYIIESKEQVFILFLAVNGSVRSKGYGSMILAQIREYAGRKPLILTIEPVEKDSPNSEQRRQRLSFYERNGYQLTSHYYYEGQERYQILTTEQSIDLERFQKLVKRAVLGLVLITV","796245","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical protein:residues 1-176 are35% similar to the protein in Lactococcus lactis subsp. lactis (gi|15673277|).Residues 70-152 are 30% similar to the protein in B.subtilis (gi|16078214|).SMu0768 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[49-133]T$	Acetyltransf_1
PS51186	$\"[1-158]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[4-152]T$	G3DSA:3.40.630.30
SSF55729	$\"[1-152]T$	SSF55729

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-176 are 35% similar to a (PROTEOME COMPLETE) protein domain (PD399629) which is seen in Q9CG15_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 14:45:37 2002","Thu Dec 20 13:21:01 2001","Wed Mar 20 14:45:37 2002","Thu Dec 20 13:21:01 2001","","Thu Dec 20 13:21:01 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0768 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 14:06:23 2002","","No significant hits to the NCBI PDB database.","SMU.844","","Residues 49 to 133 (E-value = 2.7e-06) place SMu0768 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Thu Dec 20 13:21:01 2001","24379299","","","","","","1","","","SMU.844","" "SMu0769","796274","796861","588","ATGACAAAGGAACGTTTAGCTGCGTTTACAGATGCTATACTGGCTATTATCATGACAATCTTAGTTTTAGAATTAAAGAAACCAAACCCTATTTCTTGGGAAAATCTATGGCAGTTACGAATGAATTTCTTTGCCTATACTATTTCCTTCTTTTGGTTAGGGGCCATGTGGGTTTTATTGCATCGTAATTGGCATGATATTAAAAGTATTTCCAATAAAACAGTTTGGCAGTCTTTATTAATGTTGTTTTTCTCTTCTTTTTTTCCTTATGCCACTAATCTGGTTGCAAGTGATTTCAATAATTCAGCTGCTCAGTCCTTTTATGGTAGTATTGTGATAGCAATATCTTGTTCAAATTTGTGGATGCAGAGTGATCTTTCGCATATTAAGGAAAACCAAAAGGCAGAAGCCATCCAAACTTTCTCTGTCAAAAAGAGTCGATGGCTAAAACTTGATATGTTTTTGAAAACTTTAGGATTGTTTTTAAGTTTGACCATTTGGCTATCGGCTATGATGTATACTGTTCTATTTGTTTCTTTGGCTATTGTTTTTCCTAATTCGATTACTGAAGAGAAAAAAGCTAAATAA","10.30","6.66","22587","MTKERLAAFTDAILAIIMTILVLELKKPNPISWENLWQLRMNFFAYTISFFWLGAMWVLLHRNWHDIKSISNKTVWQSLLMLFFSSFFPYATNLVASDFNNSAAQSFYGSIVIAISCSNLWMQSDLSHIKENQKAEAIQTFSVKKSRWLKLDMFLKTLGLFLSLTIWLSAMMYTVLFVSLAIVFPNSITEEKKAK","796860","","conserved hypothetical protein","Membrane, Cytoplasm","Several matches in gapped BLAST to hypothetical protein: residues 1-179 are 30% similar to the protein in Lactococcus lactis subsp. lactis (gi|15672127|).Residues 1-176 are 25% similar to the protein in Mesorhizobium loti (gi|13471525|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0312 (1e-06).","

InterPro
IPR010617
Family

Protein of unknown function DUF1211
PF06736	$\"[2-89]T$	DUF1211

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-71 are 45% similar to a (PROTEOME COMPLETE 3010001K23RIK YOAH) protein domain (PD104289) which is seen in Q9CH76_LACLA.Residues 1-70 are 48% similar to a (PROTEOME COMPLETE YHBH YBEH) protein domain (PD406798) which is seen in Q9CJ61_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 14:47:31 2002","Thu Dec 20 13:23:34 2001","Wed Mar 20 14:47:31 2002","Thu Dec 20 13:23:34 2001","","Thu Dec 20 13:23:34 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0769 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 15:58:30 2002","","No significant hits to the NCBI PDB database.","SMU.845","","Residues 2 to 89 (E-value = 2.3e-42) place SMu0769 in the DUF1211 family which is described as Protein of unknown function (DUF1211) (PF06736)","Thu Dec 20 13:23:34 2001","24379300","","","","","","1","","","SMU.845","" "SMu0770","797376","796972","405","ATGTTGCTTGAATCATATCAGTTTATCTTAAGCGTTGATAGCTTTGATAACAACTTTGGTATAAGGTTGACGGTGACCTTGTTTACGGTGACTACCTTTTTTAGGTTTGTATTTGTAAGTAACAACTTTCTTTTGTTTTCCTTGTTTTTCAACAGTTCCAACAACAGTAGCTCCTTGAACAATTGGAGTACCAACAACAGTTTTGTCGCCACCGACAAGAACAACTTGATCAAAGGTTACTTCTGCTCCAGCTTCAACATCAAGTTTTTCAACATAGATTGCTTGATCGACTTCAACTTTAACTTGTTTTCCACCAGTTTTGATGATTGCGTATGTGCTCATGATGCACCTCCTATAAGTTTTTGTTTGAGGAAATTCCTCCGTGAAGACTCGCCTAAATCGTGA","5.00","-2.02","15463","MLLESYQFILSVDSFDNNFGIRLTVTLFTVTTFFRFVFVSNNFLLFSLFFNSSNNSSSLNNWSTNNSFVATDKNNLIKGYFCSSFNIKFFNIDCLIDFNFNLFSTSFDDCVCAHDAPPISFCLRKFLREDSPKS","796977","","hypothetical protein","Cytoplasm, Extracellular","No hits in gapped BLAST found.SMu0770 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[19-39]?$	transmembrane_regions

InterPro
IPR001787
Family

Ribosomal protein L21
PD003604	$\"[4-102]T$	Ribosomal_L21p
PTHR21349	$\"[4-104]T$	Ribosomal_L21p
PF00829	$\"[3-97]T$	Ribosomal_L21p
TIGR00061	$\"[4-103]T$	L21
PS01169	$\"[73-95]T$	RIBOSOMAL_L21

","BeTs to 12 clades of COG0261COG name: Ribosomal protein L21Functional Class: JThe phylogenetic pattern of COG0261 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001787 (Ribosomal protein L21) with a combined E-value of 1.4e-33. IPB001787A 4-19 IPB001787B 60-102","Residues 4-97 are 61% similar to a (RIBOSOMAL 50S RRNA-BINDING CHLOROPLAST) protein domain (PD003604) which is seen in Q9CGL7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:36:24 2002","Thu Dec 20 13:25:45 2001","Sat Oct 12 11:36:24 2002","Thu Dec 20 13:25:45 2001","Thu Dec 20 13:25:45 2001","Thu Dec 20 13:25:45 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0771 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 13:30:46 2001","","No significant hits to the NCBI PDB database.","SMU.846","","Residues 3 to 97 (E-value = 2.9e-52) place SMu0771 in the Ribosomal_L21p family which is described as Ribosomal prokaryotic L21 protein (PF00829)","Thu Dec 20 13:25:45 2001","24379302","","","","","","1","","","SMU.846","827" "SMu0772","797361","797696","336","ATGATTCAAGCAACATTTATTCGCCGTAAGGGCATACTGGAAAGCGTTGAGCTGACTGGTCATGCTGGATCTGGTGAGTACGGCTTTGATATCGTATGCGCAGCTGTTTCAACTTTATCAATGAATTTGGTTAATGCTTTGGAAGTTTTAGCAGACTGTACAGTTAGTTTACAAATGGATGAGTTTGATGGCGGTTATATGAAGATTGATTTATCGTATATAACCAATAAATCAGATGAGAAAGTTCAATTGTTATTTGAAGCTTTTCTTCTAGGAATAACTAATCTTGCTGAAAATTCTCCAGAATTTGTAACAGCTAAGATTATGACCCAATAA","4.20","-7.86","12131","MIQATFIRRKGILESVELTGHAGSGEYGFDIVCAAVSTLSMNLVNALEVLADCTVSLQMDEFDGGYMKIDLSYITNKSDEKVQLLFEAFLLGITNLAENSPEFVTAKIMTQ","797695","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins:residues 1-109 are 57% similar to the protein in S.pyogenes (gi|15674861|). Residues 1-111 are 46% similar to the protein from S.pneumoniae (gi|15903057|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1369 (4e-34).","

InterPro
IPR007422
Family

Protein of unknown function DUF464
PF04327	$\"[1-109]T$	DUF464

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 15-107 are 36% similar to a (PROTEOME COMPLETE YKJA BH3010) protein domain (PD414624) which is seen in Q9CGL6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 16:11:02 2002","Thu Dec 20 13:37:10 2001","Thu Jan 24 16:11:02 2002","Thu Dec 20 13:37:10 2001","","Thu Dec 20 13:37:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0772 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 16:11:02 2002","","No significant hits to the NCBI PDB database.","SMU.848","","Residues 1 to 109 (E-value = 9.1e-35) place SMu0772 in the DUF464 family which is described as Protein of unknown function (DUF464) (PF04327)","Thu Dec 20 13:37:10 2001","24379303","","","","","","1","","","SMU.848","" "SMu0773","797718","798011","294","ATGTTAAAAATGAATCTTGCTAATTTGCAACTTTTCGCCCACAAAAAAGGTGGCGGTTCTACATCTAACGGACGTGATTCAGAAAGCAAACGTCTTGGTGCTAAAGCAGCTGATGGCCAAACTGTTACAGGTGGTTCAATCCTTTACCGTCAACGCGGAACACATATCTACCCAGGTGCTAACGTAGGTCGTGGTGGAGATGATACCCTTTTTGCTAAGGTTGAAGGTGTTGTTCGTTTCGAACGTAAAGGTCGCGATAAAAAACAAGTATCTGTCTACCCAATCGCAAAATAA","11.10","10.46","10404","MLKMNLANLQLFAHKKGGGSTSNGRDSESKRLGAKAADGQTVTGGSILYRQRGTHIYPGANVGRGGDDTLFAKVEGVVRFERKGRDKKQVSVYPIAK","798010","For other 'rpm' genes see SMu0638 (rpmI);SMu0108 (rpmB);SMu0306 (rpmH); SMu1185 (rpmE) and SMu1464 (rpmG). ","50S ribosomal protein L27","Extracellular","Several matches in gapped BLAST to 50S ribosomal protein L27: residues 1-97 are 94% similar to the protein in S.pyogenes (gi|15674862|). Residues 4-97 are 94% similar to the protein from S.pneumoniae (gi|15900974|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1368 (7e-50).","

InterPro
IPR001684
Family

Ribosomal protein L27
PD003114	$\"[13-85]T$	Ribosomal_L27
PR00063	$\"[15-39]T$ $\"[40-64]T$ $\"[65-89]T$	RIBOSOMALL27
PTHR15893	$\"[19-96]T$	Ribosomal_L27
PF01016	$\"[13-93]T$	Ribosomal_L27
TIGR00062	$\"[12-95]T$	L27
PS00831	$\"[45-59]T$	RIBOSOMAL_L27

noIPR
unintegrated

unintegrated
SSF110324	$\"[31-96]T$	SSF110324

","BeTs to 13 clades of COG0211COG name: Ribosomal protein L27Functional Class: JThe phylogenetic pattern of COG0211 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001684 (Ribosomal protein L27) with a combined E-value of 1.7e-39. IPB001684A 19-48 IPB001684B 49-80","Residues 13-93 are 81% similar to a (RIBOSOMAL 50S CHLOROPLAST COMPLETE PROTEOME PRECURSOR) protein domain (PD003114) which is seen in RL27_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:37:10 2002","Thu Dec 20 13:38:27 2001","Sat Oct 12 11:37:10 2002","Thu Dec 20 13:38:27 2001","Thu Dec 20 13:38:27 2001","Thu Dec 20 13:38:27 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0773 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 13:41:45 2001","","No significant hits to the NCBI PDB database.","SMU.849","","Residues 13 to 93 (E-value = 4.1e-49) place SMu0773 in the Ribosomal_L27 family which is described as Ribosomal L27 protein (PF01016)","Thu Dec 20 13:38:27 2001","24379304","","","Kimura,M. and Chow,C.K.The complete amino acid sequences of ribosomal proteins L17, L27,and S9 from Bacillus stearothermophilusEur. J. Biochem. 139 (2), 225-234 (1984)PubMed: 6365549Jeong,J.H., Kitakawa,M., Isono,S. and Isono,K.Cloning and nucleotide sequencing of the genes, rpIU and rpmA, forribosomal proteins L21 and L27 of Escherichia coliDNA Seq. 4 (1), 59-67 (1993)PubMed: 8312607Chen,R., Mende,L. and Arfsten,U.The primary structure of protein L27 from the peptidyl-tRNA binding site of Escherichia coli ribosomesFEBS Lett. 59 (1), 96-99 (1975)PubMed: 1225626","","Thu Dec 20 14:01:13 2001","1","","","SMU.849","826" "SMu0774","798325","799020","696","ATGCCAGTTAATCAGTATCAGCAAGAAGTTGGAGAAACTTTGGAACATTTTGCAGTTGGTCAAATGCCTGATGTGAAGTTTTTAGAAGGTCGCTATTGCAGTGTGGAACATATTGATGCCAGAAAACATCTAAATGACATTATTGATTTCTATTGGAAGAATGCAGTTCCGTCTGATTGGACCTACATGTTTGATCAGCCTTTTGAAACTGCTGAAGCTGTTCAAGAACGTCTCCAAGATTATGAAAAATCCGAAAACCCTTATTTTTTTGCCATTCGTGACAAAGAGACAGATAAGGTTTTAGGTACCTTTTCGCTTATGCGCATTGATCCCAAAAATCGTGTGCTTGAGATGGGGCGCGTGATTTATGCACCTGCCTTGCAGAAAACATCTGCTGCAACAGAAGCACAATACTTGGTTATGAATTATGTTTTTGAGAATCTGGGTTATCGTCGTTATGAATGGAAGTGCGATCATCTAAATCAGTCTTCTGGCAATGCTGCTAAGCGACTTGGTTTTACTTATGAGGGAACTTTCCGTAAGCATGTTGTTTATAAGGGGCGGACACGTGATACGGACTGGTTTTCTGTTATTGATCAAGATTGGCCTAAACTGAAAAAGCGGTTTGAAAACTGGCTATCACCGAAGAATTTTGATAAGACTGGTCAGCAGATAAAAGCATTAAAAGATTGTTAA","7.00","0.00","27362","MPVNQYQQEVGETLEHFAVGQMPDVKFLEGRYCSVEHIDARKHLNDIIDFYWKNAVPSDWTYMFDQPFETAEAVQERLQDYEKSENPYFFAIRDKETDKVLGTFSLMRIDPKNRVLEMGRVIYAPALQKTSAATEAQYLVMNYVFENLGYRRYEWKCDHLNQSSGNAAKRLGFTYEGTFRKHVVYKGRTRDTDWFSVIDQDWPKLKKRFENWLSPKNFDKTGQQIKALKDC","799019","","acetyltransferase, GNAT family","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical protein; possible acetyltransferase: residues 1-230 are 51% similar to the protein in S.pyogenes (gi15902280)and are 52% similar to the protein from S.pneumoniae (gi15900190).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0254 (1e-62).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[92-174]T$	Acetyltransf_1
PS51186	$\"[50-191]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[27-206]T$	G3DSA:3.40.630.30
SSF55729	$\"[23-202]T$	SSF55729

","BeTs to 5 clades of COG1670COG name: Acetyltransferases, including N-acetylases of ribosomal proteinsFunctional Class: JThe phylogenetic pattern of COG1670 is ----y-v-EBR-uj-p----xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 134-186 are 62% similar to a (TRANSFERASE PROTEOME COMPLETE) protein domain (PD000189) which is seen in Q9ZC61_YERPE.Residues 4-132 are 28% similar to a (P40586YI 2_YEAST SIMILAR) protein domain (PD207504) which is seen in Q9ZC61_YERPE.Residues 188-230 are 48% similar to a (PROTEOME HYR1 COMPLETE 3'REGION) protein domain (PD005297) which is seen in Q9ZC61_YERPE.Residues 116-204 are 34% similar to a (PROTEOME COMPLETE TRANSFERASE) protein domain (PD293627) which is seen in Q9JWK4_NEIMA.Residues 23-130 are 35% similar to a (PROTEOME HYR1 COMPLETE 3'REGION) protein domain (PD096477) which is seen in YIW2_YEAST.Residues 133-187 are 72% similar to a (HYR1 3'REGION) protein domain (PD383957) which is seen in YIW2_YEAST.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:37:43 2002","Thu Sep 7 10:03:46 2006","Thu Sep 7 10:03:46 2006","Thu Dec 20 14:02:34 2001","","Thu Sep 7 10:03:46 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu0774 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 14:04:11 2001","","No significant hits to the NCBI PDB database.","SMU.850","","Residues 92 to 174 (E-value = 4.2e-05) place SMu0774 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Thu Dec 20 14:02:34 2001","24379305","","","","","","1","","","SMU.850","889" "SMu0775","799021","799512","492","ATGGAATTTTGTCAGCATTGTGGGATGCAATTAGTAGAAAAAATGTTAGAACACGAAGGGCAAGTACCTTACTGTGAAAATTGTCAGGCTTTTCGTTTTCCTCAGCATGATCTTGCAGTATCAATGATTGTCTATGATGAGCAAATGCAAAAGATTCTTCTGATTCAGCAGTACCATATGAGACAGTATATCTTAGTGGCAGGTTATGTTAATAAAGGCGAAAAATTAGAAGAGGCTGTCAAACGCGAGGTGTTAGAAGAGACTTGTTTGACAGTTGAGATAATAGCTTTTAATGCTAGCTCTTTTTATGAAAAAAATCAAGTTTTAATGGTGAACTTTGTCTGCCGTGCCAAGAAAGCCAGCGATTTAAAACTGAACCATGAAGTGGAAGCAGCTAACTGGTTTCATCCTGACCAAGCCAAGGAAGCTATTCTATCTCCTAGCTTAGCAAAGAATTTTCTTCTAAATTGGTTGGATAAAAAAGTTCATTAA","6.20","-3.60","19024","MEFCQHCGMQLVEKMLEHEGQVPYCENCQAFRFPQHDLAVSMIVYDEQMQKILLIQQYHMRQYILVAGYVNKGEKLEEAVKREVLEETCLTVEIIAFNASSFYEKNQVLMVNFVCRAKKASDLKLNHEVEAANWFHPDQAKEAILSPSLAKNFLLNWLDKKVH","799511","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to different kinds of proteins:residues2-134 are 34% similar to N-terminal Zn-ribbon domain and C-terminal MutT domain YJAD ortholog in Clostridium acetobutylicum (gi|15893440|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1196 (2e-04).","

InterPro
IPR000086
Domain

NUDIX hydrolase
PR00502	$\"[63-77]T$ $\"[77-92]T$	NUDIXFAMILY
G3DSA:3.90.79.10	$\"[25-149]T$	NUDIX_hydrolase
PF00293	$\"[36-156]T$	NUDIX

InterPro
IPR015797
Domain

NUDIX
SSF55811	$\"[1-140]T$	NUDIX_hydrolase

noIPR
unintegrated

unintegrated
PTHR22769	$\"[42-158]T$	PTHR22769

","BeTs to 6 clades of COG0494COG name: NTP pyrophosphohydrolases (MutT family) including oxidative damage repair enzymesFunctional Class: L,RThe phylogenetic pattern of COG0494 is a-T-YqvCEBRHuj---linxNumber of proteins in this genome belonging to this COG is 6","***** IPB000086 (NUDIX hydrolase) with a combined E-value of 6.6e-08. IPB000086 63-89","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 16:12:33 2002","Thu Dec 20 14:07:13 2001","Thu Jan 24 16:12:33 2002","Thu Dec 20 14:07:13 2001","Thu Dec 20 14:07:13 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0775 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 16:12:33 2002","","No significant hits to the NCBI PDB database.","SMU.851","","Residues 36 to 156 (E-value = 1.7e-17) place SMu0775 in the NUDIX family which is described as NUDIX domain (PF00293)","Thu Dec 20 14:07:13 2001","24379306","","","","","","1","","","SMU.851","" "SMu0776","800165","801070","906","ATGAATATTCAACAATTACGTTATGTAGTGGCCATTGCTAACAGCGGTACCTTTCGTGAAGCCGCTGCTAAGCTTTTTGTCAGTCAGCCCAGTTTGTCAGTCGCTGTCAAGGATCTAGAGCAAGAACTCGGTTTTCAAATTTTTACCCGAACAACAACAGGTGCTGTTTTAACCAGTCAAGGATTAGTTTTTTACGAAAAATCATTAGAAGTTGTGAAAAGTTTTGATTCTTTTGAGAAGCGTTATGCCCAGTCTGATAGTGAGAAGAATCAATTCTCTGTTGCCAGTCAGCACTATGATTTCTTACCGCCTTTGCTGACTGCCTTTTCCAAACAGTATCCCAAATATAAAGATTTTCGTATTTTTGAAACGACAACTGCTCAGATTTTAGATGAAGTTGCCCAAGGACACAGTGAAATCGGCATTATCTATATGAATCAGCAAAACCGTAAGGGTATTTTGCAAAAAATGGATAAATTGGGGCTTGAATTTGTGGAGATGATTTCTTTTCAAACACATATTTATCTGCGTCAGAATCATCCTCTGGCAGAAAAAAAACAGTTGACTATGGATGATTTAAATGGGCTAGAAACAGTACGATTTACCCAAGAAAAGGATGAATACCTTTATTACTCAGAAAATTTGGTAGACACTAGTGAAAGTTCTCTCATTTACAATGTGACCGACCGAGCAACTCTAAATGGCATTTTAGAGCGTACAGACGCCTATGCAACTGGTTCTGGTTTTTTGGATAGTCGCAGTGTCAATGGTATTACGGTCATTCCTTTGGATGATAAATTGGATAATCGCATGGTTTATGTCAGACGCAATAGTACAAACTTATCCACGTGTGCTCTCAAATTTATCAATGTCATGTTCAATTATTTTGAAACTTATAAGCCTTAG","5.50","-4.07","34508","MNIQQLRYVVAIANSGTFREAAAKLFVSQPSLSVAVKDLEQELGFQIFTRTTTGAVLTSQGLVFYEKSLEVVKSFDSFEKRYAQSDSEKNQFSVASQHYDFLPPLLTAFSKQYPKYKDFRIFETTTAQILDEVAQGHSEIGIIYMNQQNRKGILQKMDKLGLEFVEMISFQTHIYLRQNHPLAEKKQLTMDDLNGLETVRFTQEKDEYLYYSENLVDTSESSLIYNVTDRATLNGILERTDAYATGSGFLDSRSVNGITVIPLDDKLDNRMVYVRRNSTNLSTCALKFINVMFNYFETYKP","801069","","transcriptional regulator, LysR family","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator: residues 1-297 are 71% similar to the protein in S.pneumoniae (gi15900807).Residues 1-239 are 35% similar to the protein in S.pyogenes (gi15674920).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1367 (1e-127).","

InterPro
IPR000847
Domain

Bacterial regulatory protein, LysR
PR00039	$\"[18-29]T$ $\"[29-39]T$ $\"[39-50]T$	HTHLYSR
PF00126	$\"[3-62]T$	HTH_1
PS50931	$\"[1-58]T$	HTH_LYSR

InterPro
IPR005119
Domain

LysR, substrate-binding
PF03466	$\"[85-297]T$	LysR_substrate

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-87]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-89]T$	SSF46785
SSF53850	$\"[85-297]T$	SSF53850

InterPro
IPR001872
Family

Peptidase A8, signal peptidase II
PD004304	$\"[28-150]T$	Peptidase_A8
PR00781	$\"[48-56]T$ $\"[93-108]T$ $\"[127-143]T$	LIPOSIGPTASE
PF01252	$\"[3-152]T$	Peptidase_A8
TIGR00077	$\"[1-153]T$	lspA
PS00855	$\"[96-108]T$	SPASE_II

","BeTs to 12 clades of COG0597COG name: Lipoprotein signal peptidaseFunctional Class: NThe phylogenetic pattern of COG0597 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001872 (Signal peptidase II/lipoprotein signal peptidase family (A8)) with a combined E-value of 1.3e-12. IPB001872 93-116","Residues 1-150 are 41% similar to a (SIGNAL PEPTIDASE II LIPOPROTEIN) protein domain (PD004304) which is seen in LSPA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 16:21:18 2002","Thu Dec 20 14:13:34 2001","Sat Oct 12 11:39:27 2002","Thu Dec 20 14:13:34 2001","Thu Dec 20 14:13:34 2001","Thu Dec 20 14:13:34 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0777 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 14:15:48 2001","","No significant hits to the NCBI PDB database.","SMU.853","Thu Dec 20 14:20:23 2001","Residues 3 to 152 (E-value = 2.1e-39) place SMu0777 in the Peptidase_A8 family which is described as Signal peptidase (SPase) II (PF01252)","Thu Dec 20 14:13:34 2001","24379308","","","Zhao,X.J. and Wu,H.C.Nucleotide sequence of the Staphylococcus aureus signal peptidaseII (lsp) geneFEBS Lett. 299 (1), 80-84 (1992)PubMed: 1544479Pragai,Z., Tjalsma,H., Bolhuis,A., van Dijl,J.M., Venema,G. andBron,S.The signal peptidase II (Isp) gene of Bacillus subtilisMicrobiology 143 (Pt 4), 1327-1333 (1997)PubMed: 9141696Tjalsma,H., Zanen,G., Venema,G., Bron,S. and van Dijl,J.M.The potential active site of the lipoprotein-specific (type II)signal peptidase of Bacillus subtilisJ. Biol. Chem. 274 (40), 28191-28197 (1999)PubMed: 10497172Isaki,L., Beers,R. and Wu,H.C.Nucleotide sequence of the Pseudomonas fluorescens signal peptidase II gene (lsp) and flanking genesJ. Bacteriol. 172 (11), 6512-6517 (1990)PubMed: 2121716","","Thu Dec 20 14:21:16 2001","1","","","SMU.853","825" "SMu0778","801530","802420","891","ATGGAAATTGAAATAAAAGAAGCAGGAGTGCGTCTGGATAAGGCTTTGGCTGATTTGACAGATTTGTCCCGTTCTCAGGCGAGTGAGCAAATTAAAGCTGGTCTTGTTTTAGTGAATGGCAAAACGCAAAAAGCAAAATATGCTGTTAAAGAGGGAGATATTATTCATTATGAACGTCCTCAAGAAGAAGTCTTAGACTGTGTGGCTCAGAATATTCCCCTTGAAATCGTCTATGAAGATGAGGATGTCGCTGTTATCAATAAACCGCAAGGGATGGTTGTTCATCCCTCAGTGGGGCATCCTTCAGGTACTTTGGTCAATGCTCTGCTTTTTCATATAAAAGATCTTTCGTCTATCAATGGTGTTATCAGACCAGGTATTGTCCATCGGATTGATAAAGATACTTCAGGCCTACTAATGATTGCTAAAAATGATCAAGCACATCAGGCTTTGGCGAAGGAACTGAAGGAAAAAAAGTCACTGCGTCAGTATATAGCCCTTGTACACGGCAACTTGCCAAATGACCGTGGTGTTATTGAGGCACCGATTGGCCGCAGTGAGAAGGATCGTAAGAAACAGACAGTGACTGCCAAAGGAAAACCTGCGGTGACACACTTTAAAGTTTTAGAACGCTTTGGCCAGTATAGTTTGGTGGAGCTCACGTTAGAAACAGGCAGGACACATCAAATTCGGGTTCATATGGCCTATATTGGTCACCCAGTTGCGGGAGATCCTCTCTATGCCCCCAAGAAAACATTGAAAGGTCAAGGACAGTTTTTACATGCTAAAACCTTAGGATTTACGCATCCTAAAACTGGTGAATTGATGCAATTTACTACTGAAGTACCAGTTATTTTTCAGGAGGTATTAGACCATTTGCATCATTTGTAA","9.00","5.81","32840","MEIEIKEAGVRLDKALADLTDLSRSQASEQIKAGLVLVNGKTQKAKYAVKEGDIIHYERPQEEVLDCVAQNIPLEIVYEDEDVAVINKPQGMVVHPSVGHPSGTLVNALLFHIKDLSSINGVIRPGIVHRIDKDTSGLLMIAKNDQAHQALAKELKEKKSLRQYIALVHGNLPNDRGVIEAPIGRSEKDRKKQTVTAKGKPAVTHFKVLERFGQYSLVELTLETGRTHQIRVHMAYIGHPVAGDPLYAPKKTLKGQGQFLHAKTLGFTHPKTGELMQFTTEVPVIFQEVLDHLHHL","802419","For other 'rlu' genes see SMu0580 (rluB); SMu0953 (rluE); SMu1559 (rluB) and SMu1772 (rluD).","ribosomal large subunit pseudouridine synthase D","Cytoplasm","Matches in gapped BLAST to ribosomal large subunit pseudouridine synthase D: residues 1-293 are 74% similar to the enzyme in S.pneumoniae (gi15900809)and are 65% similar to the protein from Lactococcus lactis subsp.lactis (gi15672980).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1365 (1e-127).","

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[10-55]T$	S4
SM00363	$\"[10-73]T$	S4
PS50889	$\"[10-81]T$	S4

InterPro
IPR006145
Domain

Pseudouridine synthase
PD001819	$\"[128-174]T$	PseudoU_synth
PF00849	$\"[82-236]T$	PseudoU_synth_2

InterPro
IPR006224
Family

Pseudouridine synthase, Rlu
PS01129	$\"[128-142]T$	PSI_RLU

InterPro
IPR006225
Domain

Pseudouridine synthase, RluD
TIGR00005	$\"[5-294]T$	rluA_subfam

noIPR
unintegrated

unintegrated
PTHR10436	$\"[1-296]T$	PTHR10436
SSF55120	$\"[65-294]T$	SSF55120
SSF55174	$\"[10-67]T$	SSF55174

","BeTs to 13 clades of COG0564COG name: Predicted pseudouridylate synthase family 2Functional Class: JThe phylogenetic pattern of COG0564 is ----YqVCEBRHUJGPOLINXNumber of proteins in this genome belonging to this COG is 3","***** IPB000613 (Pseudouridine synthase) with a combined E-value of 2.6e-61. IPB000613A 76-96 IPB000613B 128-167 IPB000613C 224-248 IPB000613D 257-270***** IPB002990 (Pseudouridine synthase, Rlu family) with a combined E-value of 4.6e-52. IPB002990A 76-96 IPB002990B 128-166 IPB002990C 224-248***** IPB000748 (Pseudouridine synthase, Rsu family) with a combined E-value of 1.7e-12. IPB000748A 11-36 IPB000748B 87-102 IPB000748C 128-160 IPB000748D 220-254","Residues 74-185 are 68% similar to a (SYNTHASE PSEUDOURIDINE COMPLETE PROTEOME RIBOSOMAL) protein domain (PD001819) which is seen in Q9K9V3_BACHD.Residues 188-281 are 72% similar to a (SYNTHASE PROTEOME COMPLETE PSEUDOURIDINE RIBOSOMAL LARGE) protein domain (PD350148) which is seen in Q9CGU4_LACLA.Residues 71-147 are 39% similar to a (C C-TERMINAL ORFS SHO) protein domain (PD129127) which is seen in Q9NDK7_LEIMA.Residues 9-72 are 54% similar to a (SYNTHASE PSEUDOURIDINE LARGE SUBUNIT) protein domain (PD351257) which is seen in Q9CGU4_LACLA.Residues 10-112 are 32% similar to a (MG370 URACIL COMPLETE PSEUDOURIDINE) protein domain (PD037653) which is seen in Y370_MYCPN.Residues 76-170 are 32% similar to a (COMPLETE PROTEOME SYNTHASE PSEUDOURIDINE) protein domain (PD414934) which is seen in Q9PJ89_CAMJE.Residues 191-247 are 63% similar to a (SYNTHASE COMPLETE PROTEOME PSEUDOURIDINE RIBOSOMAL LARGE) protein domain (PD224882) which is seen in Q9JVB6_NEIMA.Residues 76-183 are 28% similar to a (PROTEOME COMPLETE SYNTHASE) protein domain (PD398242) which is seen in Q9PAB2_XYLFA.Residues 124-185 are 66% similar to a (SYNTHASE PSEUDOURIDINE PROTEOME COMPLETE) protein domain (PD409890) which is seen in Q9CGU4_LACLA.Residues 73-113 are 78% similar to a (SYNTHASE PSEUDOURIDINE COMPLETE PROTEOME) protein domain (PD388247) which is seen in Q9CGU4_LACLA.Residues 72-113 are 54% similar to a (SYNTHASE D SUBUNIT LARGE) protein domain (PD405999) which is seen in RLUD_BORBU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 09:37:27 2006","Thu Sep 14 09:34:09 2006","Thu Sep 14 09:34:09 2006","Thu Dec 20 14:22:49 2001","Thu Dec 20 14:22:49 2001","Thu Dec 20 14:22:49 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0778 is paralogously related (blast p-value < 1e-3) to SMu0953, SMu1772, and SMu1559, all predicted pseudouridine synthases.","Thu Jan 24 16:24:27 2002","","No significant hits to the NCBI PDB database.","SMU.854","Thu Dec 20 14:25:36 2001","Residues 10 to 55 (E-value = 6.1e-11) place SMu0778 in the S4 family which is described as S4 domain (PF01479)Residues 82 to 236 (E-value = 1.5e-75) place SMu0778 in the PseudoU_synth_2 family which is described as RNA pseudouridylate synthase (PF00849)","Thu Sep 14 09:34:09 2006","24379309","","","","","","1","","","SMU.854","409" "SMu0779","802622","803194","573","ATGTTTTTGCGCATTATTACTTGGCTGGTAATCCTGGCAACCATTCTTTTAACTGTCTACCTTTATCAAAGAGGCTATTTAACAGATGTTAAAAAATTACGGGCTGCCATGCACCGTTATGGCAATTGGAGTCCTCTAATTTTTGTGTTATTGCAGATTATTCAAGTGGCTATTCCGATTTTACCAGGTGGTGTTTCAACTTTGGCGGGTGTTGTTATTTTTGGACCGTTTTGGGGCTTTATCTGGAATTATATTGGTATTTGTATCGGTTCTGTTTTGGGATTTCATATTGCTAGACGGTTTGGCCGTCCAGCTTTGGAGACATTTTTCAGTCCTAAAGCTCTAGCTAATTATGAACATTGGACAAATTCTGACAGTAAATTTGCTAAGTATTTTGCTTGGGCTATCTTTTTGCCAATTGCTCCAGATGATTTGCTTTGCTATTTAGCAGGAACAACCAGTATGACCTATAAACAATTCTCTCTCATTATTTTGTTGGGCAAGCCAGCTTCAATTCTTGCCTATAGTTTAGGCTTGACGACTGTCCTGTCTAAATTATTTGGTATTGGATGA","10.60","9.60","21261","MFLRIITWLVILATILLTVYLYQRGYLTDVKKLRAAMHRYGNWSPLIFVLLQIIQVAIPILPGGVSTLAGVVIFGPFWGFIWNYIGICIGSVLGFHIARRFGRPALETFFSPKALANYEHWTNSDSKFAKYFAWAIFLPIAPDDLLCYLAGTTSMTYKQFSLIILLGKPASILAYSLGLTTVLSKLFGIG","803193","","conserved hypothetical protein","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 12-183 are 34% similar to the protein in S.pneumoniae (gi|15901553|). Residues 5-176 are 42% similar to the protein from Lactococcus lactis subsp. lactis (gi|15672877|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0914 (1e-38).","

InterPro
IPR015414
Domain

SNARE associated Golgi protein
PF09335	$\"[61-181]T$	SNARE_assoc

noIPR
unintegrated

unintegrated
PTHR12677	$\"[1-167]T$	PTHR12677

","BeTs to 4 clades of COG0398COG name: Uncharacterized ACR, YdjX/UPF0043 familyFunctional Class: SThe phylogenetic pattern of COG0398 is ----y--cEBR----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 5-176 are 42% similar to a (PROTEOME YJBF COMPLETE) protein domain (PD400187) which is seen in Q9CH44_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 16:26:23 2002","Thu Dec 20 15:26:44 2001","Thu Jan 24 16:26:23 2002","Thu Dec 20 15:26:44 2001","","Thu Dec 20 15:26:44 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0779 is paralogously related (blast p-value < 1e-3) to SMu1096, and SMu1179 both predicted hypothetical proteins.","Thu Jan 24 16:26:23 2002","","No significant hits to the NCBI PDB database.","SMU.855","","No significant hits to the Pfam 11.0 database","Thu Dec 20 15:26:44 2001","24379310","","","","","","1","","","SMU.855","" "SMu0780","803417","803947","531","ATGAAAACGAAAGAAATTGTTGACGGTGTCACTATGAAGCGTGCTATCACACGTATGACTTATGAGATTATTGAGAGAAATAAGAATCTTGATAATATTGTTCTGGCTGGTATTAAGACACGTGGTGTCTTCATTGCTCGTCGTATTCAGGAACGTCTCAAACAAATTGAAGGCTTGGATGTTCCGCTTGGAGAACTTGATACCAAATCTTTCCGAGATGATGTCAAGGTCGAAGAAAATACAACTGAGATGCCTGTAGACATTACCAACCGTGATGTGATTTTGGTAGATGATGTTCTTTATACCGGTCGTACCATTCGTGCGGCTATTGATAATATTGTCAACCTTGGTCGTCCAGCTCGTGTAAGTTTAGCAGTTTTGGTTGATAGAGGTCATCGTGAGTTGCCTATTCGTGCTGATTATGTTGGCAAAAATATTCCAACCAGCAGCTCGGAAGAGATTGTTGTCAATATGGTAGAAATTGATGATAAGGACAATGTTTTATTACTTGCTAAAGAGGATAGTCTATGA","5.10","-3.75","19854","MKTKEIVDGVTMKRAITRMTYEIIERNKNLDNIVLAGIKTRGVFIARRIQERLKQIEGLDVPLGELDTKSFRDDVKVEENTTEMPVDITNRDVILVDDVLYTGRTIRAAIDNIVNLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSSEEIVVNMVEIDDKDNVLLLAKEDSL","803946","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0781(pyrP);SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH). From Genbank:[gi:730439]This protein binds to the conserved sequence in the PYR operon mRNA and disrupts the antiterminator,permitting terminator hairpin formation and promoting transcription termination.","bifunctional protein: pyrimidine operon regulatory protein and uracil phosphoribosyltransferase","Cytoplasm","Several matches in gapped BLAST to pyrimidine regulatory protein: residues 1-170 are 81% similar to the protein in S.pyogenes (gi15674866)and are 78% similar to the protein from S.pneumoniae (gi15901138).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1364 (5e-75).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[1-147]T$	Pribosyltran

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2020	$\"[4-173]T$	G3DSA:3.40.50.2020
PTHR22573	$\"[83-147]T$	PTHR22573
PTHR22573:SF9	$\"[83-147]T$	PTHR22573:SF9
SSF53271	$\"[1-174]T$	SSF53271

","BeTs to 4 clades of COG2065COG name: Pyr operon attenuation protein/uracil phosphoribosyltransferaseFunctional Class: FThe phylogenetic pattern of COG2065 is -------c-brh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 19-147 are 65% similar to a (TRANSFERASE PHOSPHORIBOSYLTRANSFERASE) protein domain (PD000249) which is seen in O52707_ENTFA.Residues 83-169 are 65% similar to a (REGULATORY COMPLETE PROTEOME PYRIMIDINE) protein domain (PD010548) which is seen in PYRR_BACSU.Residues 1-41 are 75% similar to a (PYRIMIDINE PYRAB OPERON PYRB) protein domain (PD405441) which is seen in Q9CF77_LACLA.Residues 35-75 are 51% similar to a (COMPLETE PROTEOME TRANSFERASE PYRR) protein domain (PD008075) which is seen in PYRR_BACSU.Residues 42-87 are 60% similar to a (PYRIMIDINE REGULATORY OPERON) protein domain (PD405835) which is seen in Q9CF77_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 10:12:48 2006","Tue Aug 1 10:12:48 2006","Wed Jul 12 16:09:23 2006","Thu Dec 20 15:29:15 2001","","Thu Dec 20 15:29:15 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0780 is paralogously related (blast p-value < 1e-3) to SMu0012, a predicted hypoxanthine-guanine phosphoribosyltransferase.","Thu Jan 24 16:27:17 2002","Wed Jul 12 16:09:23 2006","pdb1A4XA Chain A, Pyrr, The Bacillus Subtilis Pyrimidine Bios... 198 5e-052","SMU.856","","Residues 1 to 147 (E-value = 2.7e-17) place SMu0780 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Thu Dec 20 15:29:15 2001","24379311","","","Martinussen,J., Schallert,J., Andersen,B. and Hammer,K.The Pyrimidine Operon pyrRPB-carA from Lactococcus lactisJ. Bacteriol. 183 (9), 2785-2794 (2001)PubMed: 11292797Ghim,S.Y., Kim,C.C., Bonner,E.R., D'Elia,J.N., Grabner,G.K. andSwitzer,R.L.The Enterococcus faecalis pyr operon is regulated by autogenoustranscriptional attenuation at a single site in the 5' leaderJ. Bacteriol. 181 (4), 1324-1329 (1999)PubMed: 9973361Ghim,S.Y. and Neuhard,J.The pyrimidine biosynthesis operon of the thermophile Bacilluscaldolyticus includes genes for uracil phosphoribosyltransferaseand uracil permeaseJ. Bacteriol. 176 (12), 3698-3707 (1994)PubMed: 8206848","","Tue Aug 1 10:12:48 2006","1","","","SMU.856","696" "SMu0781","803944","805209","1266","ATGAGTCAAGAATTGAAGCTTGATGTTCAAGAGCGACCTCGTTTTGGTATGTTGTTGGGCTTATCTTTTCAACACCTTTTTGCCATGTTTGGTTCGACTGTTTTAGTCCCAATCTTAGTTGGTATTGACCCAGCTGTTGCTCTCTTATCATGTGGTCTAGGAACACTTGTTCATTTGAGTGTAACCAAGTATAAAATTCCTGCTTATATGGGCTCTAGCTTTGCCTATATTGGTGCCATGCAAACGTTAATGAAGACAGATGGTATTGCAGCAGTAGCTCAAGGAGCCATTACTGGTGGTTTGGTTTACTTCATTGTTGCTTTGGTAATTAAATGGATTGGCAATTCTTGGATTGACAAAATATTGCCGCCCGTGGTAGTCGGCCCCATTGTTATGGTTATTGGTCTTAGCCTAGCAGGCAGTGCTGTTAGTGATGTCATGACCAAAGATGGTCATTATCATCTGACTTATGTGTTCATCGGTTTGATAACGCTGTTTGCTGTCGTCTTATTTAATGTTTATGGCAAAGGAATGTTTGGTTTAATGCCTATTCTCTTTGGCCTCATTTTTGGTTACTTATTTGCTGTAGCTGTTGGAATTTTAACAGGTCAGGAAATTGTCAGTTTTTCAGGTGTTTCTAAGGCTTCTTGGATACAAATTCCTACCATTCATCTTCCTATTTTGAATGATGGTTTTAAGCTTTATCCATCAGCTATTTTAACCATGGCACCGATTGCTTTTGTAACAATGACAGAACATTTTGGTCATATCATGGTTCTCAATAGTCTAACAGGTCGTGATTTCTTCAAAAAACCGGGACTTGATAAAACTTTGACTGGCGATGGATTGGCACAAGTTGTTGCCGGTATTTTGGGAGCACCTCCTGTAACGTCTTATGGTGAAAATATTGGTGTCATGGCCCTTAATAAAATCTTCTCTGTTTATGTTATTGCTGGAGCAGCTTTTCTTGCTGTCTTGATGAGTTTTATTGGTAAAATATCAGCCTTACTGCAATCCATTCCGACTCCAGTTATCGGTGGCATATCTATTGCTCTTTTCGGTGTGATTGCTTCTAGCGGCTTAAAAATTCTTATTGAGAATAAGACAGATTTTGATAATAAGAAAAATCTGCTGATTGCTAGTATCATCTTAGTCTCTGGTATTGGTGGTTTGACGCTGCAAATTCAGAGTTTACAGATTACAGGTGTCGCTTTTTCAACCTTACTTGGTATAATTCTTTATCAAATTCTCCCAGAAAAGGACTGA","9.40","4.63","44619","MSQELKLDVQERPRFGMLLGLSFQHLFAMFGSTVLVPILVGIDPAVALLSCGLGTLVHLSVTKYKIPAYMGSSFAYIGAMQTLMKTDGIAAVAQGAITGGLVYFIVALVIKWIGNSWIDKILPPVVVGPIVMVIGLSLAGSAVSDVMTKDGHYHLTYVFIGLITLFAVVLFNVYGKGMFGLMPILFGLIFGYLFAVAVGILTGQEIVSFSGVSKASWIQIPTIHLPILNDGFKLYPSAILTMAPIAFVTMTEHFGHIMVLNSLTGRDFFKKPGLDKTLTGDGLAQVVAGILGAPPVTSYGENIGVMALNKIFSVYVIAGAAFLAVLMSFIGKISALLQSIPTPVIGGISIALFGVIASSGLKILIENKTDFDNKKNLLIASIILVSGIGGLTLQIQSLQITGVAFSTLLGIILYQILPEKD","805208","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH). ","xanthine/uracil permease","Membrane, Cytoplasm","Several matches in gapped BLAST to uracil permease: residues 8-420 are 73% similar to the enzyme in S.pyogenes (gi15674867). Residues 4-419 are 62% similar to the protein from Lactococcus lactis subsp. lactis (gi15673585).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1144 (7e-94).","

InterPro
IPR006042
Family

Xanthine/uracil permease
TIGR00801	$\"[12-416]T$	ncs2
PS01116	$\"[340-360]T$	XANTH_URACIL_PERMASE

InterPro
IPR006043
Family

Xanthine/uracil/vitamin C permease
PTHR11119	$\"[1-421]T$	Xant/urac/vitC
PF00860	$\"[16-396]T$	Xan_ur_permease

noIPR
unintegrated

unintegrated
PTHR11119:SF3	$\"[1-421]T$	PTHR11119:SF3

","BeTs to 3 clades of COG2233COG name: Xanthine/uracil permeasesFunctional Class: FThe phylogenetic pattern of COG2233 is ------v-EB-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB000444 (Xanthine/uracil permeases family) with a combined E-value of 1.8e-33. IPB000444A 280-309 IPB000444B 321-364 IPB000444B 154-197 IPB000444B 15-58","Residues 238-310 are 84% similar to a (URACIL PROTEOME COMPLETE PERMEASE) protein domain (PD400371) which is seen in Q9CF78_LACLA.Residues 9-316 are 51% similar to a (PERMEASE TRANSPORTER PROTEOME COMPLETE) protein domain (PD002574) which is seen in Q9RE00_LACPL.Residues 320-417 are 33% similar to a (URACYL PERMEASE) protein domain (PD397121) which is seen in Q9L109_STRCO.Residues 21-120 are 78% similar to a (PERMEASE URACIL PROTEOME COMPLETE) protein domain (PD018149) which is seen in Q9CF78_LACLA.Residues 320-389 are 75% similar to a (PERMEASE URACIL TRANSPORTER COMPLETE) protein domain (PD294164) which is seen in Q9L4N7_BBBBB.Residues 139-229 are 42% similar to a (URACIL PERMEASE PROTEOME COMPLETE) protein domain (PD390493) which is seen in Q9CF78_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 8 12:00:29 2007","Thu Feb 8 12:00:29 2007","Thu Sep 28 15:17:07 2006","Thu Dec 20 15:36:25 2001","Thu Dec 20 15:36:25 2001","Thu Dec 20 15:36:25 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0781 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Dec 20 15:36:51 2001","","No significant hits to the NCBI PDB database.","SMU.857","","Residues 16 to 396 (E-value = 3e-105) place SMu0781 in the Xan_ur_permease family which is described as Permease family (PF00860)","Thu Dec 20 15:36:25 2001","24379312","","","Martinussen,J., Schallert,J., Andersen,B. and Hammer,K.The Pyrimidine Operon pyrRPB-carA from Lactococcus lactisJ. Bacteriol. 183 (9), 2785-2794 (2001)PubMed: 11292797Ghim,S.Y., Kim,C.C., Bonner,E.R., D'Elia,J.N., Grabner,G.K. andSwitzer,R.L.The Enterococcus faecalis pyr operon is regulated by autogenoustranscriptional attenuation at a single site in the 5' leaderJ. Bacteriol. 181 (4), 1324-1329 (1999)PubMed: 9973361","","Thu Feb 8 12:00:29 2007","1","","","SMU.857","382" "SMu0782","805214","806140","927","ATGGTAGTTACAGATGGTGTTGTATCACTAAAGCATTTGGTTAGTATGGAAATCTTGTCCAATGAAGAAGTGCTTGGATTAATTAAAAGAGGGCTAGCCTTCAAAGAAAAGAAGGTGACTTTTTCATTGGATAGGCAATATTTTGCAGCAAACTTATTCTTTGAAGCGTCAACAAGAACGCATAAATCTTTTGAGGTTGCAGAGAAAAAATTAGGACTGGACGTCATTGAATTTGATGCTAAAACCAGTTCAGTCAATAAGGGAGAAACACTTTATGATACGATTCTAACAATGAGTGCCTTAGGGGTTGATATTTGTGTTGTGCGTCATTCACAGGATGATTATTATAAAGAATTAATTGATAGTCGTACCATCCAAACGTCGATTGTTAATGGTGGTGATGGTTCTGGCCAGCATCCTAGCCAATGTCTGCTGGATTTAATGACTATTTACGATGAGTTTGCTTCCTTTGAGAATCTTAAGATTGCTATTGCGGGAGATATTACCCATTCTCGGGTAGCCAAATCCAATATGCAAATTCTAAAACGCTTGGGAGCTCAAATTTATTTTGCAGGTCCCAAAGAATGGTATTCTTCAGAATTTGATGTTTATGGCAAATATGTTGCTATTGATGATATTATTAATCAGATAGATGTTATGATGCTTTTACGTGTGCAACATGAACGACACGATGGAAAAGAAAGTTTTTCTAAGAAAGCTTATCATCAGCATTACGGTTTAACCGAAGAACGCTACAAACAATTAAAAAGCTCTGCTATTATCATGCATCCAGCTCCTGTCAATCGTGATGTGGAGATTGCTGATAGTTTGGTTGAAGCTCCTAAATCACGGATTGTTGCTCAAATGAAAAACGGTGTTTTTGTTAGAATGGCCATTCTTGAGGCAATTTTAAGAGGCAAAACCTAG","6.90","-0.67","34711","MVVTDGVVSLKHLVSMEILSNEEVLGLIKRGLAFKEKKVTFSLDRQYFAANLFFEASTRTHKSFEVAEKKLGLDVIEFDAKTSSVNKGETLYDTILTMSALGVDICVVRHSQDDYYKELIDSRTIQTSIVNGGDGSGQHPSQCLLDLMTIYDEFASFENLKIAIAGDITHSRVAKSNMQILKRLGAQIYFAGPKEWYSSEFDVYGKYVAIDDIINQIDVMMLLRVQHERHDGKESFSKKAYHQHYGLTEERYKQLKSSAIIMHPAPVNRDVEIADSLVEAPKSRIVAQMKNGVFVRMAILEAILRGKT","806139","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH). ","aspartate transcarbamoylase","Cytoplasm","Several matches in gapped BLAST to aspartate transcarbamoylase: residues 1-307 are 73% similar to the enzyme in S.pyogenes (gi15674868)and are 70% similar to the protein from Enterococcus faecalis (gi8102063).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1044 (1e-123).","

InterPro
IPR002082
Family

Aspartate carbamoyltransferase, eukaryotic
PR00101	$\"[43-65]T$ $\"[81-90]T$ $\"[138-155]T$ $\"[220-229]T$ $\"[261-266]T$ $\"[285-299]T$	ATCASE
TIGR00670	$\"[11-305]T$	asp_carb_tr

InterPro
IPR006130
Family

Aspartate/ornithine carbamoyltransferase
PR00100	$\"[53-72]T$ $\"[139-150]T$ $\"[257-266]T$ $\"[269-292]T$	AOTCASE
PIRSF000416	$\"[11-305]T$	OCT_ATCase
PS00097	$\"[53-60]T$	CARBAMOYLTRANSFERASE

InterPro
IPR006131
Domain

Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region
PF00185	$\"[157-303]T$	OTCace

InterPro
IPR006132
Domain

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
PF02729	$\"[11-153]T$	OTCace_N

InterPro
IPR014695
Family

Aspartate carbamoyltransferase, bacterial/plant
PIRSF500169	$\"[11-307]T$	ATCase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1370	$\"[10-110]T$ $\"[139-291]T$	G3DSA:3.40.50.1370
PTHR11405	$\"[10-307]T$	PTHR11405
SSF53671	$\"[10-156]T$ $\"[157-304]T$	SSF53671

","BeTs to 12 clades of COG0540COG name: Aspartate carbamoyltransferase, catalytic chainFunctional Class: FThe phylogenetic pattern of COG0540 is amtkyqvcebr-uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002029 (Aspartate and ornithine carbamoyltransferase family) with a combined E-value of 2e-48. IPB002029A 46-73 IPB002029B 83-108 IPB002029C 129-167 IPB002029D 255-276","Residues 10-153 are 69% similar to a (CARBAMOYLTRANSFERASE ASPARTATE ORNITHINE BIOSYNTHESIS) protein domain (PD000708) which is seen in Q9L4T8_ENTFA.Residues 160-304 are 75% similar to a (ASPARTATE CARBAMOYLTRANSFERASE BIOSYNTHESIS ORNITHINE) protein domain (PD124925) which is seen in Q9L4T8_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 14:51:49 2006","Thu Dec 20 15:41:38 2001","Tue Sep 12 14:51:49 2006","Thu Dec 20 15:41:38 2001","Thu Dec 20 15:41:38 2001","Thu Dec 20 15:41:38 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0782 is paralogously related (blast p-value < 1e-3) to SMu0238,and SMu0512,both predicted ornithine carbamoyltransferases (OTCase).","Mon Jan 14 13:26:56 2002","Tue Sep 12 14:51:49 2006","pdb2AT2A Chain A, Aspartate Transcarbamoylase (E.C.2.1.3.2) (... 324 8e-090pdb1D09A Chain A, Aspartate Transcarbamoylase Complexed With ... 142 5e-035pdb1EKXA Chain A, The Isolated, Unregulated Catalytic Trimer ... 142 6e-035","SMU.858","","Residues 11 to 154 (E-value = 4e-40) place SMu0782 in the OTCace_N family which is described as Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain (PF02729)Residues 157 to 304 (E-value = 2.6e-34) place SMu0782 in the OTCace family which is described as Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain (PF00185)","Tue Sep 12 14:51:49 2006","24379313","","","Martinussen,J., Schallert,J., Andersen,B. and Hammer,K.The Pyrimidine Operon pyrRPB-carA from Lactococcus lactisJ. Bacteriol. 183 (9), 2785-2794 (2001)PubMed: 11292797Elagoz,A., Abdi,A., Hubert,J.C. and Kammerer,B.Structure and organisation of the pyrimidine biosynthesis pathwaygenes in Lactobacillus plantarum: a PCR strategy for sequencingwithout cloningGene 182 (1-2), 37-43 (1996)PubMed: 8982065","","Thu Dec 20 15:44:24 2001","1","","","SMU.858","361" "SMu0783","806269","807357","1089","ATGGGAAAAAGACTTTTAATATTAGAAGATGGAACAATTTTTGAAGGACAGGCTTTTGGAGCAGACCTTGATGTAACCGGTGAGATTGTCTTTAATACTGGTATGACAGGTTATCAGGAATCTATCACTGATCAGTCTTACAATGGTCAGATTTTGACATTTACCTATCCGCTTGTTGGCAACTATGGAATTAATCGTGATGATTATGAAAGTATTAAACCCACTTGTAAGGGAGTTGTCGTTTCAGAAAATGCACGTCGGGCTAATAATTGGCGCAAGCAGATGACCTTGGATGAATTTTTGAAATCAAAAAACATTCCAGGTATTTCTGGGATTGATACACGAGCACTGACCAAAATTATTCGTCATCATGGAACAATGAAGGCAACTCTGGCTAATGAGGGTGACTCTATTGAGCATCTACAAGATCAATTACGTGCGACTGTTCTTCCAACAAATAATATTGAACAGGTATCAACTAAAACCGCTTATCCAGCTCCGGGTGTTGGGAAAAATATTGTTTTGGTTGATTTCGGACTGAAACATTCTATCTTACGTGAATTTTCAAAACGTAATTGTAATGTAACTGTTGTTCCTTATAATACGACGGCTCAAGAGATTTTAAATTTAAACCCAGATGGTATCATGCTGTCAAATGGACCGGGAAATCCTCAAGATGTTCCGGAAGCTTTAGAGATGATTCGCGGTGTACAAGGTAAAATTCCAATTTTTGGTATTTGTATGGGGCATCAACTTTTTAGTTTGGCAAATGGTGCCAGTACCTACAAGATGAAATTCGGTCATCGTGGTTTTAATCATGCGGTGCGTGAAATTGCAACAGGACGTATTGATTTTACCAGTCAAAATCATGGTTATGCTGTTTCGCGTGATAATTTACCAGAGGAGCTTATTATTACGCACGAAGAAATTAATGATAAATCAATTGAAGGTGTACGTCATCGATACTACCCCGCTTTCTCTGTTCAGTATCATCCAGATGCTGCGCCGGGACCACATGACGCTTCTTATCTCTTTGATGAATTTTTAGAATTAATTGATGCTTTTCAATTGGAAAAAGCTAGCAAGTGA","6.20","-5.23","40192","MGKRLLILEDGTIFEGQAFGADLDVTGEIVFNTGMTGYQESITDQSYNGQILTFTYPLVGNYGINRDDYESIKPTCKGVVVSENARRANNWRKQMTLDEFLKSKNIPGISGIDTRALTKIIRHHGTMKATLANEGDSIEHLQDQLRATVLPTNNIEQVSTKTAYPAPGVGKNIVLVDFGLKHSILREFSKRNCNVTVVPYNTTAQEILNLNPDGIMLSNGPGNPQDVPEALEMIRGVQGKIPIFGICMGHQLFSLANGASTYKMKFGHRGFNHAVREIATGRIDFTSQNHGYAVSRDNLPEELIITHEEINDKSIEGVRHRYYPAFSVQYHPDAAPGPHDASYLFDEFLELIDAFQLEKASK","807356","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0782 (pyrB); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH).For other 'car' genes see SMu0784 (carB).For carbamoyl phosphate synthetase, large subunit see SMu0784. ","carbamoyl-phosphate synthase,small subunit","Cytoplasm","Several matches in gapped BLAST to carbamoyl-phosphate synthase, small subunit: residues 1-356 are 85% similar to the enzyme in S.pneumoniae (gi|15901136|and from S.pyogenes (gi|15674869|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1043 (1e-167).","

InterPro
IPR000991
Domain

Glutamine amidotransferase class-I
PF00117	$\"[174-351]T$	GATase

InterPro
IPR001317
Domain

Carbamoyl-phosphate synthase, GATase region
PR00099	$\"[173-187]T$ $\"[212-226]T$ $\"[242-258]T$ $\"[259-276]T$ $\"[284-295]T$	CPSGATASE

InterPro
IPR002474
Domain

Carbamoyl-phosphate synthase, small chain
PF00988	$\"[2-149]T$	CPSase_sm_chain
SSF52021	$\"[1-151]T$	CP_synthsmall

InterPro
IPR006220
Domain

Anthranilate synthase component II/delta crystallin
PR00097	$\"[215-224]T$ $\"[242-253]T$ $\"[327-340]T$	ANTSNTHASEII

InterPro
IPR006274
Domain

Carbamoyl-phosphate synthase, small subunit
TIGR01368	$\"[4-354]T$	CPSaseIIsmall

InterPro
IPR011702
Domain

Glutamine amidotransferase superfamily
PR00096	$\"[215-224]T$ $\"[242-253]T$ $\"[327-340]T$	GATASE

InterPro
IPR012998
Active_site

Glutamine amidotransferase, class I, active site
PS00442	$\"[242-253]T$	GATASE_TYPE_I

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.880	$\"[148-358]T$	G3DSA:3.40.50.880
PTHR11405	$\"[4-358]T$	PTHR11405
PTHR11405:SF4	$\"[4-358]T$	PTHR11405:SF4
SSF52317	$\"[132-352]T$	SSF52317

","BeTs to 11 clades of COG0505COG name: Carbamoylphosphate synthase small subunitFunctional Class: E,FThe phylogenetic pattern of COG0505 is amt-YqvceBr-uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002474 (Carbamoyl-phosphate synthase small chain) with a combined E-value of 4.8e-134. IPB002474A 6-12 IPB002474B 27-55 IPB002474C 89-131 IPB002474D 172-198 IPB002474E 213-224 IPB002474F 256-295 IPB002474G 307-348***** IPB000991 (Glutamine amidotransferase class-I) with a combined E-value of 5.5e-10. IPB000991A 242-251 IPB000991B 325-335","Residues 277-353 are 80% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE SMALL CHAIN) protein domain (PD330440) which is seen in Q9L4N5_BBBBB.Residues 4-140 are 79% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE SMALL CHAIN) protein domain (PD001375) which is seen in Q9L4N5_BBBBB.Residues 144-187 are 70% similar to a (PROTEOME GLUTAMINASE SUBUNIT COMPLETE) protein domain (PD410446) which is seen in Q9CF80_LACLA.Residues 189-271 are 80% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE SMALL CHAIN) protein domain (PD105693) which is seen in Q9CF80_LACLA.Residues 261-301 are 58% similar to a (PROTEOME SUBUNIT COMPLETE SMALL) protein domain (PD389162) which is seen in Q9WZ28_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:59:07 2002","Mon Apr 1 17:04:30 2002","Sat Oct 12 11:59:07 2002","Thu Dec 20 15:48:07 2001","Thu Dec 20 15:48:07 2001","Thu Dec 20 15:48:07 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0783 is paralogously related (blast p-value < 1e-3) to SMu0484, a predicted anthranilate synthase component II, and SMu0974, a predicted GMP synthase.","Thu Jan 24 16:30:33 2002","Thu Dec 20 15:48:07 2001","pdb|1JDB|F Chain F, Carbamoyl Phosphate Synthetase From Escheri... 302 6e-083pdb|1C30|B Chain B, Crystal Structure Of Carbamoyl Phosphate Sy... 298 9e-082pdb|1CS0|B Chain B, Crystal Structure Of Carbamoyl Phosphate Sy... 297 1e-081","SMU.859","","Residues 3 to 149 (E-value = 7.7e-89) place SMu0783 in the CPSase_sm_chain family which is described as Carbamoyl-phosphate synthase small chain, CPSase domain (PF00988)Residues 174 to 351 (E-value = 1e-68) place SMu0783 in the GATase family which is described as Glutamine amidotransferase class-I (PF00117)","Thu Dec 20 15:48:07 2001","24379314","","","Elagoz,A., Abdi,A., Hubert,J.C. and Kammerer,B.Structure and organisation of the pyrimidine biosynthesis pathwaygenes in Lactobacillus plantarum: a PCR strategy for sequencingwithout cloningGene 182 (1-2), 37-43 (1996)PubMed: 8982065Quinn,C.L., Stephenson,B.T. and Switzer,R.L.Functional organization and nucleotide sequence of the Bacillussubtilis pyrimidine biosynthetic operonJ. Biol. Chem. 266 (14), 9113-9127 (1991)PubMed: 1709162","","Thu Dec 20 15:51:40 2001","1","","","SMU.859","360" "SMu0784","807537","810716","3180","ATGCCTAAACGTACAGATATTAAAAAAATTATGGTAATTGGTTCTGGTCCAATTATCATTGGACAGGCTGCTGAATTTGATTATGCAGGAACCCAAGCCTGTCTTGCTTTAAAAGAAGAAGGCTATAGTGTCGTTCTGGTCAATTCAAACCCAGCGACAATCATGACAGATAAAGAAATTGCAGATAAGGTCTATATTGAACCTATCACTATTGAATTTGTAACTCGAATTTTAAGAAAAGAACGTCCCGATGCAATACTGCCAACTCTTGGTGGACAGACAGGTCTTAATATGGCGATGGAATTATCAAGAGCTGGGATTCTTGATGAGTTGGGTGTTGAACTTTTAGGAACCAAGCTGTCTGCTATTGATCAGGCTGAAGATCGCGATCTTTTCAAGCAATTGATGGAAGATTTAGAACAGCCTATTCCAGAATCTGATATTGTTAATAGCGTTGACGAAGCTGTTGCATTTGCTGCTAAGATTGGCTATCCAGTCATTGTTCGTCCGGCATTTACGCTTGGCGGCACAGGCGGCGGTATGTGTGCAGATGAGAAAGAACTTCGTGAAATTGCTGAAAATGGTCTCAAACTGTCACCTGTAACGCAATGTCTGATTGAGCGTTCTATTGCTGGCTTTAAGGAAATTGAATATGAAGTTATGAGAGACAGTGCAGATAATGCTCTGGTTGTCTGTAACATGGAAAATTTTGATCCAGTTGGTATTCATACAGGGGATTCTATCGTTTTTGCGCCAACGCAGACACTTTCAGATATCGAAAATCAAATGCTGCGTGATGCTAGTTTAAAAATTATTCGTGCCCTTAAGATTGAAGGTGGTTGTAATGTACAGCTGGCTCTGGATCCGCATAGCTTTAAATACTATGTCATTGAGGTTAATCCACGTGTCTCACGTTCATCAGCTCTAGCTTCTAAAGCAACTGGCTACCCTATCGCTAAATTAGCTGCCAAAATCGCTGTTGGTTTAACTCTGGATGAGATGATTAATCCAGTTACGGGGACAACTTATGCCATGTTTGAACCAGCTTTGGACTATGTAGTGGCTAAGATTCCGCGTTTTCCATTTGATAAATTTGAACATGGTGAACGTCGTCTTGGAACACAGATGAAGGCGACTGGTGAAGTCATGGCTATTGGGCGTAATATTGAAGAAAGTCTTCTCAAAGCTTGCCGTTCCCTTGAAATCGGTGTTTACCATAATGAGATGCCAGAGCTTACCAATGTTAGTGACGACGCTTTGGTAGCCAAAATTGTTAAGGCTCAAGATGATCGTCTTTTCTATCTTTCTGAAGCCATTCGTCGTGGATATTCCATTGAGGAACTGTCGGATTTAACAAAAATTGATCTTTTCTTTCTTGATAAACTCTTGCATATCTTTGAAATTGAAACAGAATTAGCAGCCAAGGTTGGTGATATTGCTATTCTTAAAGAAGCTAAGCACAATGGTTTTGCTGATCGAAAAATTGCTGATATCTGGCAGATGACAGCAGACGCTGTTCGCAAGCTTCGTCTTGACAACAAGATAATTCCTGTTTATAAGATGGTTGATACTTGTGCGGCTGAATTTGAATCTGCAACACCTTATTTCTACTCGACTTACGAATGGGAAAATGAGTCCATCAAATCAGAAAAAGAATCCGTCATTGTTTTGGGTTCAGGTCCGATTCGTATCGGACAGGGAGTTGAATTTGATTATGCGACAGTTCATTCTGTCAAAGCCATTCAAAACGCAGGTTATGAAGCTATTATTATGAATTCCAATCCTGAGACCGTTTCAACAGATTTTTCAGTTTCTGATAAACTTTATTTTGAACCGCTAACTTTTGAAGATGTTATGAATGTAATTGAGTTGGAGCAACCTAAAGGTGTCATTGTTCAGTTTGGCGGACAAACAGCTATCAACTTGGCAGAACCATTATCGCATGCTGGTGTGACAATTCTGGGTACGCAAGTAGCTGATCTTGACCGTGCAGAAGACCGTGATCTTTTCGAGCAGGCTTTAAAAGATTTAAATATTCCTCAGCCGCCGGGACAAACAGCAACAAATGAAGAAGAGGCGGTCGCTTCGGCTCGTAAAATTGGTTTTCCAGTGCTTGTTCGCCCGTCTTACGTTCTTGGGGGACGTGCTATGGAAATTGTTGAAAGTGAAAACGATTTACGCTCTTACATGCGAACAGCTGTAAAGGCCAGTCCTGATCATCCTGTCTTGGTTGATTCTTATTTAGTCGGCAGTGAATGTGAGGTAGATGCCATTTCTGACGGTAAGGACGTTCTTATTCCCGGCATTATGGAACATATTGAGCGTGCCGGTGTCCACTCAGGAGATTCTATGGCTGTCTATCCACCACAAACTCTTTCAAAAGAAGTTCAGGCAACCATTGCAGATTATACAAAACGCTTGGCTATCGGACTAAACTGTATCGGGATGATGAATATTCAGTTTGTCATCAAAGACGAAACCGTTTATGTTATTGAAGTTAATCCGCGTGCCAGTCGAACAGTACCGTTTTTATCTAAAGTGACAGATATACCAATGGCACAAATTGCTACTAAATTGATTTTAGGAAGCAGTCTGACTGAACTTGGCTATAAGGATGGCCTTTATCCAGAAAGTCAAAATGTTCATGTTAAAGCTCCAGTCTTTTCCTTCACCAAGTTAGCTAAGGTTGACAGTCTTTTAGGACCTGAGATGAAATCTACAGGCGAAGTCATGGGGACTGATTCAACTCTTGAAAAAGCGCTGTATAAAGCTTTTGAAGCGTCTTATTTCCACCTTCCTGCTTTTGGTAATGTCATTTTTACTATTGCTGATGATACTAAAGAAGAAGCATTGGCGTTAGCACGTCGCTTCTCAAATATTGGTTACAGTATTTTAGCCACGGAAGGTACCGCTAAATTCTTTGCAGAAAACAATTTAGAAGCAGTCCTTGTTAATAAATTGGGTGAAGATGATGACAATGACATTCCTGCCTATGTTCGATCTGGTAAAGTACAAGCTATTATTAATACAGTTGGCAACAAACGTACCTTTGATGAAGATGGTGCGGCTATTCGCAGCTCTGCCATTGAACATGGTGTACCACTTTTTACTGCGCTTGACACAGCAGATGCCATGGTAAGGGTTCTTGAAAGCCGAGGTTTTATTACACAAGCTATATAA","4.60","-49.89","116046","MPKRTDIKKIMVIGSGPIIIGQAAEFDYAGTQACLALKEEGYSVVLVNSNPATIMTDKEIADKVYIEPITIEFVTRILRKERPDAILPTLGGQTGLNMAMELSRAGILDELGVELLGTKLSAIDQAEDRDLFKQLMEDLEQPIPESDIVNSVDEAVAFAAKIGYPVIVRPAFTLGGTGGGMCADEKELREIAENGLKLSPVTQCLIERSIAGFKEIEYEVMRDSADNALVVCNMENFDPVGIHTGDSIVFAPTQTLSDIENQMLRDASLKIIRALKIEGGCNVQLALDPHSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMINPVTGTTYAMFEPALDYVVAKIPRFPFDKFEHGERRLGTQMKATGEVMAIGRNIEESLLKACRSLEIGVYHNEMPELTNVSDDALVAKIVKAQDDRLFYLSEAIRRGYSIEELSDLTKIDLFFLDKLLHIFEIETELAAKVGDIAILKEAKHNGFADRKIADIWQMTADAVRKLRLDNKIIPVYKMVDTCAAEFESATPYFYSTYEWENESIKSEKESVIVLGSGPIRIGQGVEFDYATVHSVKAIQNAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIELEQPKGVIVQFGGQTAINLAEPLSHAGVTILGTQVADLDRAEDRDLFEQALKDLNIPQPPGQTATNEEEAVASARKIGFPVLVRPSYVLGGRAMEIVESENDLRSYMRTAVKASPDHPVLVDSYLVGSECEVDAISDGKDVLIPGIMEHIERAGVHSGDSMAVYPPQTLSKEVQATIADYTKRLAIGLNCIGMMNIQFVIKDETVYVIEVNPRASRTVPFLSKVTDIPMAQIATKLILGSSLTELGYKDGLYPESQNVHVKAPVFSFTKLAKVDSLLGPEMKSTGEVMGTDSTLEKALYKAFEASYFHLPAFGNVIFTIADDTKEEALALARRFSNIGYSILATEGTAKFFAENNLEAVLVNKLGEDDDNDIPAYVRSGKVQAIINTVGNKRTFDEDGAAIRSSAIEHGVPLFTALDTADAMVRVLESRGFITQAI","810715","For other 'car' genes see SMu0783 (carA).For carbamoyl-phosphate synthase, small subunit SMu0783.","carbamoyl-phosphate synthase, large subunit","Cytoplasm","Several matches in gapped BLAST to carbamoyl-phosphate synthase, large subunit: residues 1-1059 are 87% similar to the enzyme in S.pneumoniae (gi|15901135|)and are 83% similar to the protein from S.pyogenes (gi|15674870|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1042 (0.0).","

InterPro
IPR005479
Domain

Carbamoyl-phosphate synthase L chain, ATP-binding
PF02786	$\"[128-362]T$ $\"[666-868]T$	CPSase_L_D2
PS00866	$\"[164-178]T$ $\"[702-716]T$	CPSASE_1
PS00867	$\"[296-303]T$ $\"[830-837]T$	CPSASE_2

InterPro
IPR005480
Domain

Carbamoyl-phosphate synthetase large chain, oligomerisation
PF02787	$\"[420-540]T$	CPSase_L_D3

InterPro
IPR005481
Domain

Carbamoyl-phosphate synthetase large chain, N-terminal
PF00289	$\"[6-126]T$ $\"[550-664]T$	CPSase_L_chain

InterPro
IPR005483
Domain

Carbamoyl-phosphate synthetase large chain
PR00098	$\"[19-33]T$ $\"[48-58]T$ $\"[168-180]T$ $\"[204-223]T$ $\"[239-256]T$ $\"[296-325]T$ $\"[378-396]T$	CPSASE

InterPro
IPR006275
Domain

Carbamoyl-phosphate synthase, large subunit, glutamine-dependent
TIGR01369	$\"[2-1049]T$	CPSaseII_lrg

InterPro
IPR011607
Domain

MGS-like
PF02142	$\"[949-1037]T$	MGS

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[133-327]T$ $\"[671-861]T$	ATP_GRASP

InterPro
IPR013816
Domain

ATP-grasp fold, subdomain 2
G3DSA:3.30.470.20	$\"[187-401]T$ $\"[725-929]T$	ATP_grasp_subdomain_2

InterPro
IPR013817
Domain

Pre-ATP-grasp fold
G3DSA:3.40.50.20	$\"[1-116]T$ $\"[545-651]T$	Pre-ATP_grasp

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1380	$\"[930-1050]T$	G3DSA:3.40.50.1380
PTHR11405	$\"[1-1050]T$	PTHR11405
SSF48108	$\"[394-548]T$	SSF48108
SSF52335	$\"[925-1047]T$	SSF52335
SSF52440	$\"[1-127]T$ $\"[548-668]T$	SSF52440
SSF56059	$\"[128-400]T$ $\"[666-928]T$	SSF56059

","BeTs to 11 clades of COG0458COG name: Carbamoylphosphate synthase large subunit (split gene in MJ)Functional Class: E,FThe phylogenetic pattern of COG0458 is aMT-YQvceBr-uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000901 (Carbamoyl-phosphate synthase) with a combined E-value of 5e-12. IPB000901 697-720 IPB000901 159-182","Residues 862-926 are 72% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE LIGASE LARGE) protein domain (PD000705) which is seen in CARB_LACPL.Residues 481-551 are 71% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE LIGASE LARGE) protein domain (PD001652) which is seen in O32771_BBBBB.Residues 414-472 are 69% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE LIGASE CHAIN) protein domain (PD001706) which is seen in CARB_LACPL.Residues 937-993 are 52% similar to a (IMP PURINE BIOSYNTHESIS SYNTHETASE) protein domain (PD002195) which is seen in CARB_BACSU.Residues 999-1059 are 49% similar to a (SYNTHETASE CARBAMOYL-PHOSPHATE CHAIN) protein domain (PD093174) which is seen in CARB_LACPL.Residues 356-401 are 67% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE INCLUDES:) protein domain (PD402775) which is seen in Q9KPH9_VIBCH.Residues 601-647 are 72% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE LIGASE LARGE) protein domain (PD188843) which is seen in Q9K9V9_BACHD.Residues 58-102 are 51% similar to a (LIGASE BIOSYNTHESIS CHAIN PYRIMIDINE) protein domain (PD194596) which is seen in PYR1_YEAST.Residues 601-641 are 87% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE LIGASE SYNTHETASE) protein domain (PD186868) which is seen in O32771_BBBBB.Residues 672-860 are 80% similar to a (LIGASE SYNTHETASE CARBOXYLASE COMPLETE PROTEOME) protein domain (PD000180) which is seen in O32771_BBBBB.Residues 554-600 are 69% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE LIGASE SYNTHETASE CHAIN) protein domain (PD000704) which is seen in CARB_SULSO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 11:59:35 2002","Wed Jan 2 08:32:53 2002","Sat Oct 12 11:59:35 2002","Wed Jan 2 08:29:09 2002","Wed Jan 2 08:29:09 2002","Wed Jan 2 08:29:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0784 is paralogously related (blast p-value < 1e-3) to SMu1582, a predicted acetyl-CoA carboxylase, biotin carboxylase, SMu1206, a predicted conserved hypothetical protein and SMu0546, a predicted D-alanine-D-alanine ligase.","Thu Jan 24 16:33:43 2002","Wed Jan 2 08:29:09 2002","pdb|1BXR|A Chain A, Structure Of Carbamoyl Phosphate Synthetase... 996 0.0pdb|1CE8|A Chain A, Carbamoyl Phosphate Synthetase From Escheri... 994 0.0pdb|1A9X|A Chain A, Carbamoyl Phosphate Synthetase: Caught In T... 956 0.0","SMU.860","","Residues 6 to 126 (E-value = 2.4e-55) place SMu0784 in the CPSase_L_chain family which is described as Carbamoyl-phosphate synthase L chain, N-terminal domain (PF00289)Residues 128 to 362 (E-value = 5.9e-131) place SMu0784 in the CPSase_L_D2 family which is described as Carbamoyl-phosphate synthase L chain, ATP binding domain (PF02786)Residues 420 to 540 (E-value = 7.8e-60) place SMu0784 in the CPSase_L_D3 family which is described as Carbamoyl-phosphate synthetase large chain, oligomerisation domain (PF02787)Residues 550 to 664 (E-value = 6.9e-26) place SMu0784 in the CPSase_L_chain family which is described as Carbamoyl-phosphate synthase L chain, N-terminal domain (PF00289)Residues 628 to 861 (E-value = 3.6e-05) place SMu0784 in the Dala_Dala_ligas family which is described as D-ala D-ala ligase (PF01820)Residues 666 to 873 (E-value = 3.8e-27) place SMu0784 in the CPSase_L_D2 family which is described as Carbamoyl-phosphate synthase L chain, ATP binding domain (PF02786)Residues 938 to 1037 (E-value = 1.3e-30) place SMu0784 in the MGS family which is described as MGS-like domain (PF02142)","Wed Jan 2 08:29:09 2002","24379315","","","Martinussen,J. and Hammer,K.The carB gene encoding the large subunit of carbamoylphosphatesynthetase from Lactococcus lactis is transcribed monocistronicallyJ. Bacteriol. 180 (17), 4380-4386 (1998)PubMed: 9721272Elagoz,A., Abdi,A., Hubert,J.C. and Kammerer,B.Structure and organisation of the pyrimidine biosynthesis pathwaygenes in Lactobacillus plantarum: a PCR strategy for sequencingwithout cloningGene 182 (1-2), 37-43 (1996)PubMed: 8982065Quinn,C.L., Stephenson,B.T. and Switzer,R.L.Functional organization and nucleotide sequence of the Bacillussubtilis pyrimidine biosynthetic operonJ. Biol. Chem. 266 (14), 9113-9127 (1991)PubMed: 1709162Ghim,S.Y., Nielsen,P. and Neuhard,J.Molecular characterization of pyrimidine biosynthesis genes fromthe thermophile Bacillus caldolyticusMicrobiology 140 (Pt 3), 479-491 (1994)PubMed: 7516791","","Wed Jan 2 08:38:09 2002","1","","","SMU.860","119" "SMu0785","810983","812317","1335","ATGATAAAGAGAAAAATAGGAGGGAGAAGATTTATGCCAAAAAGAAAAGAGAAAATGACCAGAAAGAAGAAAGGCTGGATTATTGGCGGTAGTTTTGCAGCTATTTTGATAGTATTAGGCCTTATTTGGGCTAGATTACAGCAAATAAGCCAAACATCATCAAATAATGTTGGTTATCAAACAGTCAAAGTCAAAGAAGGAACGATTGCCTCTTCAACTTTGCTGTCAGGAACTGTTAAGTCTGAATCGGAACAGTATGTCTATTATGATAGTAACAAGGGAACCAATCCTAAGGTTATGGTGTCTGCAGGAGATCAAGTTACTGCTGGTCAACAATTGGTTCAGTATGATAATAGTACTGCGCAAGCAGCTTATGATCAAGCAGTCAGGAATCTAGATAAGGTTAACCGTCAAATTACAAATTATAAAACTTATGGTACGCTGCCATCACAAGATAGTTCTTATGACAGCGGATCCAACGTAGGAAATTCTAGCAGTAATTCTGGCAGTGGAAATAGCAATTCTTTTAATAGTGGCTATAATATGAATAATACGAATGCGCTGGGAAGTTCAAGTGCCGCTGCTATTACCCCAGTAAACTCTGTATCATCAGATCAGCAGCTGCAAGATTTGTATGATGCACAAGCCAATGCACAAGATGAAGTTAATAAGGCTCAAAAAGCTCTAGATGATACTTCGGTTAATAGTGAGGTGACAGGAACAGTTGCTGAAGTTAATAATGATGTTGATCCCTCTGGTAAAACCAGCAAAGCTCTTGTTCATATTACCAGTGAAGGTAAATTACAAATCCAAGGCACCTTAACTGAATATGACTTGGCTAATATCAAAGTGGGCCAAGAAGTTAGCATTAAATCTAAGGTTTATGGTAATAAGAAATGGTCAGGAAAAATTTCTTATATTTCTAATTATCCTAATCAGGATCAAAGCAGTCAGTCTCAAGCGGCTGATTCATCTGGAAGCGGCTCTTCTTCAAATTCAGCCGCTTATAACTATAAAGTTGATTTGACAAGTGATATAGGAGACTTAAAACAAGGCTTCACGGTATCTGTAGAGGTAGTCAATGGCAATAAGAGTCTAGTTATTCCTAATTCAGCACTGGTTACAAAAGACAATAAAAACTATGTCTGGGTTTATGATAAAACGAATTCTAAAGTTTTGAAAAAAGAGGTTGCTGTTGGAAATGCTGATGCTAAATCGCAAGAAATTTCATCTGGTCTTGATAAAGGACAAACTATTATTTCTAATCCAGATAAGAATTTAAAAGAAGGCAAGAAGATTGAAAAACCTTCTAGTAAGGCTAATGAAAAGAGGTGA","10.10","11.25","47705","MIKRKIGGRRFMPKRKEKMTRKKKGWIIGGSFAAILIVLGLIWARLQQISQTSSNNVGYQTVKVKEGTIASSTLLSGTVKSESEQYVYYDSNKGTNPKVMVSAGDQVTAGQQLVQYDNSTAQAAYDQAVRNLDKVNRQITNYKTYGTLPSQDSSYDSGSNVGNSSSNSGSGNSNSFNSGYNMNNTNALGSSSAAAITPVNSVSSDQQLQDLYDAQANAQDEVNKAQKALDDTSVNSEVTGTVAEVNNDVDPSGKTSKALVHITSEGKLQIQGTLTEYDLANIKVGQEVSIKSKVYGNKKWSGKISYISNYPNQDQSSQSQAADSSGSGSSSNSAAYNYKVDLTSDIGDLKQGFTVSVEVVNGNKSLVIPNSALVTKDNKNYVWVYDKTNSKVLKKEVAVGNADAKSQEISSGLDKGQTIISNPDKNLKEGKKIEKPSSKANEKR","812316","","conserved hypothetical protein","Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 35-434 are 45% similar to S.pyogenes (gi|15674871|).Residues 33-434 are 39% similar to S.pneumoniae (gi|15902737|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1361 (3e-99).","

InterPro
IPR006143
Family

Secretion protein HlyD
TIGR01730	$\"[59-436]T$	RND_mfp

","BeTs to 4 clades of COG0845COG name: Membrane permeases, predicted cation efflux pumpsFunctional Class: RThe phylogenetic pattern of COG0845 is -----QvCEB-hUJ--ol--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 352-433 are 32% similar to a (PLASMID BACG) protein domain (PD415036) which is seen in O52969_ENTFA.Residues 262-420 are 27% similar to a (COMPLETE PROTEOME MEMBRANE EFFLUX) protein domain (PD000988) which is seen in Q9K883_BACHD.Residues 26-139 are 32% similar to a (PROTEOME COMPLETE YVRP BH3123) protein domain (PD075357) which is seen in O35007_BACSU.Residues 47-307 are 22% similar to a (ATP-BINDING CASSETTE PLASMID) protein domain (PD013310) which is seen in O54498_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 16:34:37 2002","Wed Jan 2 08:48:34 2002","Thu Jan 24 16:34:37 2002","Wed Jan 2 08:48:34 2002","","Wed Jan 2 08:48:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0785 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 16:34:37 2002","","No significant hits to the NCBI PDB database.","SMU.862","","No significant hits to the Pfam 11.0 database","Wed Jan 2 08:48:34 2002","24379316","","","","","","1","","","SMU.862","1017" "SMu0786","812323","813030","708","GTGAGTGATAGAAAAGAACTCATTCATCTTAAAGGGGTAACAAAAAGTTATCATAATGGAAATCAAGAATTGCAGGTCCTCAAAGGAATTGATTTAACAGTTAATGAAGGAGATTTTCTAGCTATTATGGGGCCGTCTGGTTCGGGAAAGTCAACTTTAATGAATATTATTGGCCTTTTAGATCGCCCTAGTTCAGGAACCTATCATTTATCACAACAAAGTGTTGAAAAATTAAATGATAGCAAATTAGCACATGTTCGCAATCAAAAAATTGGTTTCGTCTTTCAGCAATTCTTCCTTCTCTCTAAATTAGATGCTCTGCAAAATGTGGAACTGCCACTCATTTATGCAGGTGTCAGTCCTTCTCAGCGCAAAAAAACAGCCAAAGAGTTTTTAGATAAGGTAGAACTATCTGAACGGATGAAGCATTTGCCTTCAGAGTTATCAGGTGGACAAAAGCAAAGAGTTGCTATTGCTCGTGCCCTAGTCAATAATCCATCTATTATTCTTGCTGATGAACCAACGGGTGCTCTTGACACTAAGACCGGTAATCAAATAATGGAATTATTGACTGAGCTTAATAATGAAGGAAAAACGATTATTATGGTAACGCATGAACCTGAGATTGCTGACTATGCTAAAAGAAAAATTGTCATCCGTGATGGTGAGATTACAGAAGACAGCCAGCAAATGGCTGAATTAGAATAG","6.50","-1.55","26032","MSDRKELIHLKGVTKSYHNGNQELQVLKGIDLTVNEGDFLAIMGPSGSGKSTLMNIIGLLDRPSSGTYHLSQQSVEKLNDSKLAHVRNQKIGFVFQQFFLLSKLDALQNVELPLIYAGVSPSQRKKTAKEFLDKVELSERMKHLPSELSGGQKQRVAIARALVNNPSIILADEPTGALDTKTGNQIMELLTELNNEGKTIIMVTHEPEIADYAKRKIVIRDGEITEDSQQMAELE","813029","For other component see SMu0787 (MSD1).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several matches in gapped BLAST to ABC transporter, ATP-binding protein: residues 5-235 are 76% similar to the protein in S.pneumoniae (gi|15900679|). Residues 8-228 are 77% similar to the protein from S.pyogenes (gi|15674872|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1360 (6e-99).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[147-190]T$	Q8DUP1_STRMU_Q8DUP1;
PF00005	$\"[37-222]T$	ABC_tran
PS50893	$\"[8-234]T$	ABC_TRANSPORTER_2
PS00211	$\"[148-162]T$	ABC_TRANSPORTER_1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[36-223]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[5-226]T$	no description
PTHR19222	$\"[8-227]T$	ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF32	$\"[8-227]T$	ABC TRANSPORTER

","BeTs to 14 clades of COG1136COG name: ABC-type (unclassified) transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1136 is AMt--QVCEBRHUJGPOLinxNumber of proteins in this genome belonging to this COG is 8","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.6e-41. IPB001140A 26-72 IPB001140B 145-183 IPB001140C 199-228","Residues 7-219 are 26% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 132-234 are 29% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in YN26_MYCTU.Residues 5-232 are 26% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 148-188 are 56% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459) which is seen in MDR1_LEIEN.Residues 80-124 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230) which is seen in O31711_BACSU.Residues 27-78 are 73% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in O54499_BBBBB.Residues 147-189 are 88% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O54499_BBBBB.Residues 128-209 are 38% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD033004) which is seen in O59176_PYRHO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 10:09:41 2002","Wed Jan 2 10:01:51 2002","Tue Oct 22 07:58:06 2002","Wed Jan 2 10:01:25 2002","Wed Jan 2 10:01:25 2002","Wed Jan 2 10:01:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0786 is paralogously related (blast p-value < 1e-3) to SMu1288, SMu1246, SMu1231, SMu0916, SMu1762, SMu1210, SMu1751, SMu1068, SMu0517, SMu0731, SMu0218, SMu1380, SMu0849, SMu0418, SMu1920, SMu1001, SMu0594, SMu0971, SMu0884, SMu1949, SMu1003, SMu1079, SMu1757, SMu0390, SMu1950, SMu0234, SMu0235, SMu0335, SMu1023, SMu0805, SMu0907, SMu1428, SMu1316, SMu0216, SMu0374, SMu1517, SMu1710, SMu1518, SMu1410, SMu1064, SMu0475, SMu0824, SMu1037, SMu1649, SMu0258, SMu0836, SMu0825, SMu0752, SMu0476, SMu1065, SMu0024, SMu1811, SMu0986, SMu0596, SMu0944, SMu0976, SMu0164, SMu1036, SMu1724, SMu0950, SMu0224, SMu1959, SMu1545, SMu0987, SMu0837, SMu0823, SMu1306, SMu0729, SMu1093, SMu0666, SMu1050, and SMu1686 all with ATP-binding capabilities.","Fri Apr 26 08:45:25 2002","Wed Jan 2 10:01:25 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 140 1e-034pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 110 2e-025","SMU.863","","Residues 37 to 222 (E-value = 5.6e-56) place SMu0786 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Jan 2 10:01:25 2002","24379317","","","","Tue Oct 29 10:09:41 2002","","1","","","SMU.863","" "SMu0787","813040","814284","1245","ATGGAAAATTGGAAATTTGCTCTTTCTTCTATTCTTAGTCATAAAATGCGTTCCTTTCTGACGATGCTGGGGATTATCATAGGGGTAGCTTCGGTTGTCATGATTATGGCTCTAGGTCAAGGTCTTAAAAAAGGGATTAGTGATCAAGTCAATAAAGAACAAAAAAATTTAAATGTTTATTATAAAACAAAGGCTGAACAAGAAGCAGAAAAGAACCCTTATTATCAAGTTGATACCTCTGACAGCAGTGCGAAAGCTCCAGATATTCAGGAGGCTTGGGTAGAAAAGATCGCTCAAGATACTAAAGGCGTTTCAGGTTATTATATTACGAATAGTAAAACGGCGACCGTTTCTTATCGGAAAAAGAGCTCTAAAAATGTTAATATAACAGGAATTAACAGGACTTATTTATCCATCAAGAAATTTAAAATAATAGCAGGCCGCTCCTTTACTAGTAACGACTATGATAAATTTGGTCGTATTATTATGCTAGACGCCAATCTAGCAAAAAAGCTCTTTGGAGACAATGAAACTGCTCTCAATAAGGTGATTACTTTATCTAATAAGAGTTATCTGGTTGTCGGTGTTTATGAAGATCCTAATGCTGGAACAGCAACTTATGGAACGACTTCGGGTGGGAATGCCATTATGACTAATACTCAAGTTGCCAGCGAATTTGGTGTGAAAGAAAATGATCAAATTTATTTCCATATTAATGATGTTAGTCAGGCCAATAAAATTGGTAAGGAAACAGGTGCGGCTCTCACCAAGATATCTGGAGCTAAAGATGGTTTATATGAAAACTATAATATGGATAATATTGTAAAGCAAGCTAATCAGATGGCTTCCATGTACACTATTGCCTTTGGTGTTATTGCAGGTATCTCCCTTCTAGTTGGTGGTATTGGTGTTATGAATATTATGCTGGTATCTGTTACTGAGCGTACGCGTGAAATAGGTTTACGAAAGGCTTTAGGTGCTACTCGTATTAAAATTTTGAATCAATTTTTGATTGAATCCATTGTTTTAACTATTTTGGGAGGACTAATTGGTCTTGGAATTGCTTATATGGGAGTAACAGCTATCACTCCAGCTTTAAAAGCTCAGCATATTGTTCCAGCAATTTCTCTGCAGGTTATTCTCATTAGTATTGCTTTCTCTGCTTTTGTTGGGATAGTCTTTGGACTTCTGCCAGCTAATAAGGCAAGTAAATTAAATCCAATTGATGCCTTAAGATATGAGTAA","10.30","13.73","44941","MENWKFALSSILSHKMRSFLTMLGIIIGVASVVMIMALGQGLKKGISDQVNKEQKNLNVYYKTKAEQEAEKNPYYQVDTSDSSAKAPDIQEAWVEKIAQDTKGVSGYYITNSKTATVSYRKKSSKNVNITGINRTYLSIKKFKIIAGRSFTSNDYDKFGRIIMLDANLAKKLFGDNETALNKVITLSNKSYLVVGVYEDPNAGTATYGTTSGGNAIMTNTQVASEFGVKENDQIYFHINDVSQANKIGKETGAALTKISGAKDGLYENYNMDNIVKQANQMASMYTIAFGVIAGISLLVGGIGVMNIMLVSVTERTREIGLRKALGATRIKILNQFLIESIVLTILGGLIGLGIAYMGVTAITPALKAQHIVPAISLQVILISIAFSAFVGIVFGLLPANKASKLNPIDALRYE","814283","For other component see SMu0786 (NBD1).","ABC transporter, permease component","Membrane, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-414 are 49% similar to S.pyogenes (gi|15674873|) and 44% similar to S.pneumoniae (gi|15900680|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1359 (1e-138).","

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[231-407]T$	FtsX

","BeTs to 13 clades of COG0577COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0577 is AMt--QVcEBRHuj--OLinxNumber of proteins in this genome belonging to this COG is 7","***** IPB003838 (DUF214) with a combined E-value of 3.7e-31. IPB003838A 304-351 IPB003838B 398-411","Residues 1-155 are 33% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD101245) which is seen in YKNZ_BACSU.Residues 8-340 are 18% similar to a (OF PROTEOME COMPLETE CLUSTER) protein domain (PD025026) which is seen in Q9S4J0_STRPN.Residues 290-332 are 88% similar to a (PROTEOME COMPLETE MEMBRANE TRANSMEMBRANE) protein domain (PD003665) which is seen in YKNZ_BACSU.Residues 16-187 are 26% similar to a (PROTEOME COMPLETE MEMBRANE INTEGRAL) protein domain (PD155814) which is seen in O83928_TREPA.Residues 375-414 are 62% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD395496) which is seen in Q9K885_BACHD.Residues 2-161 are 30% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD101250) which is seen in P74738_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 10:39:37 2002","Fri Apr 26 13:39:37 2002","Mon Oct 28 10:39:37 2002","Wed Jan 2 09:06:29 2002","Wed Jan 2 09:06:29 2002","Wed Jan 2 09:06:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0787 is paralogously related (blast p-value < 1e-3) to SMu1288,a predicted ABC transporter membrane protein subunit, SMu1000,a predicted ABC transporter permease protein, SMu1067,SMu1245, and SMu1230, all predicted secretion ABC transport permease.","Thu Jan 24 16:43:16 2002","","No significant hits to the NCBI PDB database.","SMU.864","","Residues 231 to 407 (E-value = 1.7e-46) place SMu0787 in the FtsX family which is described as Predicted permease (PF02687)","Wed Jan 2 09:06:29 2002","24379318","","","","","","1","","","SMU.864","" "SMu0788","814687","814962","276","ATGGCAGTAAAAATCCGTTTGACTCGTATGGGTTCTAAAAAGAAACCTTTCTATCGTATCAACGTTGCAGATTCACGTGCACCACGTGATGGTCGCTTCATCGAAACGGTTGGAACATACAATCCGCTTGTAACTGAAAATCAAGTGACTCTCAAAGAAGATCGTATTCTTGAGTGGCTAGGCAATGGTGCTCAACCATCAGATACTGTTCGTAACATCCTTTCAAAAGCTGGAATTATGCAAAAATTCCACGAAGCTAAATACTCAAAGAAGTAA","11.00","9.22","10393","MAVKIRLTRMGSKKKPFYRINVADSRAPRDGRFIETVGTYNPLVTENQVTLKEDRILEWLGNGAQPSDTVRNILSKAGIMQKFHEAKYSKK","814961","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu1841 (rps10); SMu1838 (rps19);SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).","30S ribosomal protein S16","Periplasm, Cytoplasm","Several matches in gapped BLAST to 30S ribosomal protein S16: residues 1-90 are 87% similar to the protein in S.pyogenes (gi|15674875|) and are 86% similar to the protein from S.pneumoniae (gi|15900669|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1358 (2e-43).","

InterPro
IPR000307
Family

Ribosomal protein S16
PD003791	$\"[11-82]T$	Ribosomal_S16
G3DSA:3.30.1320.10	$\"[2-88]T$	Ribosomal_S16
PTHR12919	$\"[2-84]T$	Ribosomal_S16
PF00886	$\"[9-67]T$	Ribosomal_S16
TIGR00002	$\"[3-80]T$	S16
SSF54565	$\"[2-83]T$	Ribosomal_S16

noIPR
unintegrated

unintegrated
PTHR12919:SF4	$\"[2-84]T$	PTHR12919:SF4

","BeTs to 13 clades of COG0228COG name: Ribosomal protein S16Functional Class: JThe phylogenetic pattern of COG0228 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000307 (Ribosomal protein S16) with a combined E-value of 6.7e-27. IPB000307 2-38 IPB000307 22-58","Residues 9-67 are 89% similar to a (RIBOSOMAL 30S CHLOROPLAST MITOCHONDRIAL MITOCHONDRION) protein domain (PD003791) which is seen in RS16_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 13:59:16 2002","Wed Jan 2 09:07:54 2002","Thu Jan 24 16:43:48 2002","Wed Jan 2 09:07:54 2002","Wed Jan 2 09:07:54 2002","Wed Jan 2 09:07:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0788 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 09:09:53 2002","Wed Jan 2 09:07:54 2002","pdb|1EMW|A Chain A, Solution Structure Of The Ribosomal Protein... 77 4e-016","SMU.865","","Residues 9 to 67 (E-value = 6.4e-30) place SMu0788 in the Ribosomal_S16 family which is described as Ribosomal protein S16 (PF00886)","Wed Jan 2 09:07:54 2002","24379319","","","Higo,K., Otaka,E. and Osawa,S.Purification and characterization of 30S ribosomal proteins fromBacillus subtilis: correlation to Escherichia coli 30S proteins Mol. Gen. Genet. 185 (2), 239-244 (1982)PubMed: 6806564Arndt,E., Scholzen,T., Kromer,W., Hatakeyama,T. and Kimura,M.Primary structures of ribosomal proteins from the archaebacteriumHalobacterium marismortui and the eubacterium BacillusstearothermophilusBiochimie 73 (6), 657-668 (1991)PubMed: 1764513","","Wed Jan 2 09:14:25 2002","1","","","SMU.865","824" "SMu0789","814973","815212","240","ATGGATACCATTGAAAATCTGATTATCGCTATTGTGAAACCTTTAATTTCACAACCAGATAATTTTACCATAAAAATTGAAGATACACCTGAGTTTTTGGAGTATCATCTTGACTTAGATTCTAGTGATATTGGCCGAATTATCGGTAAAAAAGGTCGCACCATCACAGCGATAAGATCGATTGTCTATTCGGTTCCAACTCAAGGTAAAAAAGTGAGACTTGTGATTGATGAAAAGTAG","5.90","-0.77","8907","MDTIENLIIAIVKPLISQPDNFTIKIEDTPEFLEYHLDLDSSDIGRIIGKKGRTITAIRSIVYSVPTQGKKVRLVIDEK","815211","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-79 are 77% similar to the protein in S.pyogenes (gi|15674876|). Residues 4-78 are 40% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673550|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1357 (2e-28).","

InterPro
IPR004088
Domain

KH, type 1
PF00013	$\"[34-59]T$	KH_1

noIPR
unintegrated

unintegrated
SSF54791	$\"[20-59]T$	SSF54791

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-74 are 41% similar to a (RNA-BINDING PROTEOME COMPLETE RPSP-TRMD) protein domain (PD009089) which is seen in Q9CFB3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 16:45:55 2002","Wed Jan 2 09:20:12 2002","Thu Jan 24 16:45:55 2002","Wed Jan 2 09:20:12 2002","","Wed Jan 2 09:20:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0789 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 24 16:45:55 2002","","No significant hits to the NCBI PDB database.","SMU.866","","No significant hits to the Pfam 11.0 database","Wed Jan 2 09:20:12 2002","24379320","","","","","","1","","","SMU.866","942" "SMu0790","815301","815819","519","ATGAAGTATTTTAATGTTGGAAAGATTGTCAATACGCAAGGACTTCGAGGAGAAGTTCGTGTTTTATCTGTGACTGATTTTGCAGACGAACGCTTTAAAAAAGGAAGTCAGCTGGCTCTTTTTGATAAAAAAGATCACTTTGCCATGACTGTTGAGATTGCCAGCCACAGAAAACATAAAAATTTTGATATTGTCAAATTTAAAGGACTCTATCATATCAATGATGTTGAAAAATATCGTGATTTCACCCTCAAAGTTACTGAAGATCATCTGGCAGATTTAGAAGATGGTGAATTCTATTATCATGAAATCATTGGACTTGATGTTTATGAGAATGATATCTTGATTGGACAGGTCAAGGAAATTTTACAACCCGGTGCCAATGATGTTTGGGTTGTTAAACGCAAAGGAAAAAAAGATCTGCTTTTGCCTTACATTCCTTCGGTTATTTTAAAGGTTGATGTACCAAATGGCCGTATTGATGTGACTGTTTTAGAAGGATTGGACGATGAAAATTGA","6.00","-3.55","19807","MKYFNVGKIVNTQGLRGEVRVLSVTDFADERFKKGSQLALFDKKDHFAMTVEIASHRKHKNFDIVKFKGLYHINDVEKYRDFTLKVTEDHLADLEDGEFYYHEIIGLDVYENDILIGQVKEILQPGANDVWVVKRKGKKDLLLPYIPSVILKVDVPNGRIDVTVLEGLDDEN","815818","For other 'rim' genes see SMu0349 (rimI). From Genbank: [gi:14423885]This protein is essential for efficient processing of 16S rRNA.It probably is part of the 30S subunit prior to or during the final step in the processing of 16S free 30S ribosomal subunits.It could be some accessory protein needed for efficient assembly of the 30S subunit.RIMM is needed in a step prior to RBFA during the maturation of 16S rRNA.It has affinity for free ribosomal 30S subunits, not for 70S ribosomes.","16S rRNA processing protein","Cytoplasm","Several matches in gapped BLAST to 16S rRNA processing protein RimM: residues 1-172 are 75% similar to the protein in S.pneumoniae (gi15902730)and are 72% similar to the protein from S.pyogenes (gi15674881).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1355 (2e-76).","

InterPro
IPR002676
Domain

RimM protein
PF01782	$\"[5-90]T$	RimM

InterPro
IPR007903
Domain

PRC-barrel
PF05239	$\"[96-169]T$	PRC

InterPro
IPR011033
Domain

PRC-barrel-like
SSF50346	$\"[86-163]T$	PRCH_cytoplasmic

InterPro
IPR011961
Family

16S rRNA processing protein RimM
TIGR02273	$\"[3-168]T$	16S_RimM

","BeTs to 10 clades of COG0806COG name: RimM protein, required for 16S rRNA processingFunctional Class: JThe phylogenetic pattern of COG0806 is -----qvcebrhuj--ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB002676 (RimM) with a combined E-value of 1.4e-26. IPB002676A 6-26 IPB002676B 92-134 IPB002676C 142-150","Residues 2-46 are 71% similar to a (PROCESSING RRNA 16S PROTEOME) protein domain (PD351351) which is seen in RIMM_LACLA.Residues 53-162 are 71% similar to a (PROCESSING RRNA 16S COMPLETE) protein domain (PD358463) which is seen in RIMM_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 09:59:22 2006","Tue Aug 1 09:59:22 2006","Tue Aug 1 09:59:12 2006","Wed Jan 2 09:22:52 2002","Wed Jan 2 09:22:52 2002","Wed Jan 2 09:22:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0790 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 09:23:05 2002","","No significant hits to the NCBI PDB database.","SMU.867","","Residues 5 to 90 (E-value = 1.2e-33) place SMu0790 in the RimM family which is described as RimM N-terminal domain (PF01782)Residues 96 to 169 (E-value = 1e-16) place SMu0790 in the PRC family which is described as PRC-barrel domain (PF05239)","Tue Aug 1 09:59:12 2006","24379321","","","","","","1","","","SMU.867","695" "SMu0791","815809","816531","723","ATGAAAATTGATATTTTGACTCTCTTTCCAGAGATGTTTGCTCCTTTGGAACATTCAATTGTTGGTAAGGCACAGACAAAGGGGCTTTTAGAAATTAACTATCATAATTTTCGTGAAAATGCAGAGAAGGCTCGCCATGTAGATGATGAACCTTACGGTGGCGGTCAAGGGATGCTTTTGCGCGCTCAGCCTATTTTTGATACTTTTGATAAAATTGCTGCTAAAAAACCGCGTGTCATACTTTTAGATCCAGCGGGCCAGCAATTTAATCAGTCTTATGCAGAAGATCTGGCTCAAGAAGGTGAACTTATTTTTATCTGCGGTCACTATGAAGGATATGATGAGCGTATTAAAACTTTAGTGACTGATGAGATTTCTTTAGGGGATTTTATTTTAACAGGCGGCGAATTGGCTGCTATGACAATTATTGATGCGACAGTCAGGCTGATTCCAGAAGTTATCGGTAAAGAAGCGAGTCATCAAGATGATAGTTTTTCGTCAGGTCTCTTAGAATATCCTCAGTATACACGTCCTTATGAATATAGGGGAATGAAGGTCCCCGATGTTCTCCTGTCTGGACATCATGAAAATATTCGCTTATGGCGTCTAGAGCAAAGCTTACGTAAGACATGGGAACGTAGGCCTGATCTGCTAGAGCATTATCAGTTTACTCAGGAAGAAAAGCAACTTTTGGAAAAAATAAAGAGTGAGGGATCAAGCTAA","5.00","-11.10","27484","MKIDILTLFPEMFAPLEHSIVGKAQTKGLLEINYHNFRENAEKARHVDDEPYGGGQGMLLRAQPIFDTFDKIAAKKPRVILLDPAGQQFNQSYAEDLAQEGELIFICGHYEGYDERIKTLVTDEISLGDFILTGGELAAMTIIDATVRLIPEVIGKEASHQDDSFSSGLLEYPQYTRPYEYRGMKVPDVLLSGHHENIRLWRLEQSLRKTWERRPDLLEHYQFTQEEKQLLEKIKSEGSS","816530","For other 'trm' genes see SMu1945 (trmU) and SMu0791 (trmD).From Genbank:[gi:3915143]This protein specifically methylates guanosine-37 in various tRNAs.","tRNA (guanine-N1)-methyltransferase","Cytoplasm","Several matches in gapped BLAST to tRNA (guanine-N1)-methyltransferase: residues 1-235 are 85% similar to the enzyme in S.pneumoniae (gi15900673)and are 83% similar to the protein from S.pyogenes (gi15674882).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1354 (1e-118).","

InterPro
IPR002649
Family

tRNA (guanine-N1-)-methyltransferase
PD004978	$\"[32-219]T$	TRMD_STRMU_Q8DUN6;
PF01746	$\"[21-215]T$	tRNA_m1G_MT
TIGR00088	$\"[1-234]T$	trmD: tRNA (guanine-N1)-methyltransferase

noIPR
unintegrated

unintegrated
G3DSA:1.10.1270.20	$\"[164-237]T$	no description
G3DSA:3.40.1280.10	$\"[1-154]T$	no description
PIRSF000386	$\"[1-238]T$	tRNA-(m1G37) methyltransferase

","BeTs to 12 clades of COG0336COG name: tRNA-(guanine-N1)-methyltransferaseFunctional Class: JThe phylogenetic pattern of COG0336 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002649 (tRNA (guanine-N1-)-methyltransferase) with a combined E-value of 1.8e-105. IPB002649A 1-13 IPB002649B 37-62 IPB002649C 97-118 IPB002649D 124-165 IPB002649E 169-217","Residues 21-226 are 74% similar to a (METHYLTRANSFERASE TRNA) protein domain (PD004978) which is seen in Q9CFB7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 09:25:13 2006","Wed Jan 2 09:35:12 2002","Thu Sep 14 09:25:13 2006","Wed Jan 2 09:35:12 2002","Wed Jan 2 09:35:12 2002","Wed Jan 2 09:35:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0791 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 09:37:10 2002","","No significant hits to the NCBI PDB database.","SMU.868","","Residues 21 to 225 (E-value = 6.7e-118) place SMu0791 in the tRNA_m1G_MT family which is described as tRNA (Guanine-1)-methyltransferase (PF01746)","Wed Jan 2 09:35:12 2002","24379322","","","Bystroem,A.S., Hjalmarsson,K.J., Wikstroem,P.M. and Bjoerk,G.R.The nucleotide sequence of an Escherichia coli operon containinggenes for the tRNA(m1G)methyltransferase, the ribosomal proteinsS16 and L19 and a 21-K polypeptideEMBO J. 2, 899-905 (1983)Hjalmarsson,K.J., Bystrom,A.S. and Bjork,G.R.Purification and characterization of transfer RNA (guanine-1)methyltransferase from Escherichia coliThe Journal of biological chemistry. 258 (2), 1343-1351 (1983)PubMed: 6337136Wikstrom,P.M., Lind,L.K., Berg,D.E. and Bjork,G.R.Importance of mRNA folding and start codon accessibility in theexpression of genes in a ribosomal protein operon of EscherichiacoliJ. Mol. Biol. 224 (4), 949-966 (1992)PubMed: 1569581","","Wed Jan 2 09:47:41 2002","1","","","SMU.868","408" "SMu0792","816615","817628","1014","ATGGAGGAAGAAAAATTGACATCTGAAAAAGAGATTTATGATATAACCGTTATCGGTGGCGGACCGGTTGGTCTTTTTACAGCTTTTTATGCTGGTTTGCGTGGTATTTCTGTAAAAGTGATTGAAAGTTTATCTGAGCTTGGTGGTCAACCAGCCATTTTATATCCAGAAAAGGTGATTTATGATATCCCAGCCTTTCCTGCTATTACTGGAGCAGATTTGGTAGATAATCTGATTGAACAATTGGAGCGCTTTAAGGATAAAACGACTATTTGTTTAAAAGAAGAAGTTAAAACATTTGAAAAAGAGAATGCTATTTTTACAATTACAACAAATAAAGGGAATCATTTTTCGAAAGCCATTATTATTGCTTGTGGAAATGGTGCCTTTGCGCCGCGTCGATTGGGCTTGGACGATGAGGAACGTTATGCAGACCATAATCTCTTTTACAATGTTCACAAACTAGACCAATTTGCTGGTAAAAAGGTTGTTATTTGTGGTGGCGGCGACTCTGCTGTTGACTGGGCTAATGCTCTGGATAAGATTGCTGAAAGTGTCACATTGGTACACCGTCGTGATGCCTTTCGCGCTCATGAACATAGTGTAGAAGTTCTGAAAACTTCTCATGTTAATATCATGACACCTTACGTACCGCTTGAGTTAAAAGGAGAAGGTGATGAAGCAACCAGTCTTGTGATTCAAAAGGTCAAATCAGAAGAAACCAAAGAGTTGTCACTTGATTCGCTTATTGTTAGTTTTGGATTTTCAACCTCCAACAAAAACCTCAAAAGTTGGAATATTGATTATAAGCGTTCAAGTATTAATGTATCTCCTCTTTTTGAAACCAGTCAGACAGGGGTTTTTGCTATTGGAGATGCTGCAGAATATGAAGGCAAAATTGATTTAATTGCAACAGGATTTGGAGAGGCACCAACAGCAGTTAACCAAGCCATCAAATACATTTATCCTGAGCGTGATAATCGTGTCGTTCATTCCACATCATTGATAAAATAA","5.20","-10.18","37142","MEEEKLTSEKEIYDITVIGGGPVGLFTAFYAGLRGISVKVIESLSELGGQPAILYPEKVIYDIPAFPAITGADLVDNLIEQLERFKDKTTICLKEEVKTFEKENAIFTITTNKGNHFSKAIIIACGNGAFAPRRLGLDDEERYADHNLFYNVHKLDQFAGKKVVICGGGDSAVDWANALDKIAESVTLVHRRDAFRAHEHSVEVLKTSHVNIMTPYVPLELKGEGDEATSLVIQKVKSEETKELSLDSLIVSFGFSTSNKNLKSWNIDYKRSSINVSPLFETSQTGVFAIGDAAEYEGKIDLIATGFGEAPTAVNQAIKYIYPERDNRVVHSTSLIK","817627","For other 'trx' genes see SMu1789 (trxH); SMu0420 (trxB) and SMu1699 (trxA)From Genbank:[gi:549128]This protein is a component of the thioredoxin-thioredoxin reductase system which may be involved in biosynthesis of penicillins and cephalosporins and may be important in determining the thiol-disulfide redox balance . ","thioredoxin reductase","Cytoplasm","Several matches in gapped BLAST to thioredoxin reductase: residues 13-336 are 79% similar to the enzyme in S.pyogenes (gi|15674883|). Residues 11-335 are 56% similar to the protein from S.pneumoniae (gi|15903464|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1353 (1e-146).","

InterPro
IPR000103
Domain

Pyridine nucleotide-disulphide oxidoreductase, class-II
PR00469	$\"[14-36]T$ $\"[71-81]T$ $\"[119-127]T$ $\"[158-182]T$ $\"[209-225]T$ $\"[282-300]T$	PNDRDTASEII

InterPro
IPR000759
Family

Adrenodoxin reductase
PR00419	$\"[14-36]T$ $\"[37-50]T$ $\"[163-177]T$	ADXRDTASE

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[132-193]T$	Q8DUN5_STRMU_Q8DUN5;
PF00070	$\"[162-254]T$	Pyr_redox

InterPro
IPR003042
Family

Aromatic-ring hydroxylase
PR00420	$\"[14-36]T$ $\"[284-299]T$	RNGMNOXGNASE

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[14-36]T$ $\"[121-130]T$ $\"[162-187]T$ $\"[247-261]T$ $\"[287-294]T$	FADPNR
PF07992	$\"[14-298]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[12-126]T$ $\"[133-254]T$	no description
PTHR22912	$\"[16-318]T$	DISULFIDE OXIDOREDUCTASE

","BeTs to 16 clades of COG0492COG name: Thioredoxin reductase/alkyl hydroperoxide reductaseFunctional Class: OThe phylogenetic pattern of COG0492 is amtkYQVcEBrhUJgpolinXNumber of proteins in this genome belonging to this COG is 3","***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 3.3e-15. PR00368A 14-36 PR00368B 121-130 PR00368C 162-187 PR00368E 287-294***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 4.9e-09. IPB000103A 14-34 IPB000103C 128-176 IPB000103E 282-319***** PR00419 (Adrenodoxin reductase family signature) with a combined E-value of 3.5e-06. PR00419A 14-36 PR00419D 163-177","Residues 161-323 are 43% similar to a (OXIDOREDUCTASE FLAVOPROTEIN FAD CENTER REDOX-ACTIVE) protein domain (PD000139) which is seen in Q9UXN1_SULSO.Residues 14-298 are 24% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD132291) which is seen in Q9PHV6_CAMJE.Residues 163-212 are 52% similar to a (OXIDOREDUCTASE THIOREDOXIN FAD) protein domain (PD345560) which is seen in Q9CF34_LACLA.Residues 135-185 are 47% similar to a (PROTEOME FAD THIOREDOXIN COMPLETE) protein domain (PD352196) which is seen in Q9K7F3_BACHD.Residues 10-134 are 55% similar to a (COMPLETE PROTEOME FAD FLAVOPROTEIN) protein domain (PD348239) which is seen in Q9K7F3_BACHD.Residues 240-324 are 35% similar to a (PROTEOME THIOREDOXIN COMPLETE REDUCTASE) protein domain (PD299615) which is seen in Q9KCZ0_BACHD.Residues 199-302 are 46% similar to a (REDUCTASE PROTEOME COMPLETE FAD) protein domain (PD294764) which is seen in O05268_BACSU.Residues 10-74 are 44% similar to a (REDUCTASE FLAVOPROTEIN OXIDOREDUCTASE FAD THIOREDOXIN) protein domain (PD396269) which is seen in Q9WZX3_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 20:21:42 2002","Wed Jan 2 10:11:20 2002","Sun Oct 27 20:21:42 2002","Wed Jan 2 10:08:41 2002","Wed Jan 2 10:08:41 2002","Wed Jan 2 10:08:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0792 is paralogously related (blast p-value < 1e-3) to SMu0420, a predicted NADH oxidase, SMu0693, a predicted NADH oxidase/alkyl hydroperoxidase reductase, SMu1299 and SMu0116,both predicted dihydrolipoamide dehydrogenases and SMu0762, a predicted glutathione reductase.","Thu Jan 24 16:49:57 2002","Wed Jan 2 10:08:41 2002","pdb|1F6M|A Chain A, Crystal Structure Of A Complex Between Thio... 85 2e-017pdb|1TDF| Thioredoxin Reductase (E.C.1.6.4.5) Mutant With Cy... 83 3e-017pdb|1TRB| Thioredoxin Reductase (E.C.1.6.4.5) Mutant With Cy... 83 3e-017","SMU.869","","Residues 14 to 305 (E-value = 8.6e-35) place SMu0792 in the Pyr_redox family which is described as Pyridine nucleotide-disulphide oxidoreductase (PF00070)","Wed Jan 2 10:08:41 2002","24379323","","","Cohen,G., Yanko,M., Mislovati,M., Argaman,A., Schreiber,R.,Av-Gay,Y. and Aharonowitz,Y.Thioredoxin-thioredoxin reductase system of Streptomycesclavuligerus: sequences, expression, and organization of the genesJ. Bacteriol. 175 (16), 5159-5167 (1993)PubMed: 8349555Aharonowitz,Y., Av-Gay,Y., Schreiber,R. and Cohen,G.Characterization of a broad-range disulfide reductase fromStreptomyces clavuligerus and its possible role in beta-lactamantibiotic biosynthesisJ. Bacteriol. 175 (3), 623-629 (1993)PubMed: 8423136","","Wed Jan 2 10:19:30 2002","1","","","SMU.869","407" "SMu0793","817697","818494","798","ATGGGGGAGTATATAATAACATGTGTAAACGATTTCAACAAGGAGGTGACTCTTATTTTAAAATCTGAACGTAAGCAGATTATCATGGAAAAGTTAGCGCAGGAGAATTTTGTAACCTTAGAATTTCTTGTTGGTGTCCTTGATACATCTGAGTCAACCGTTCGCAGAGATTTAGATGAGTTAGCAAGTGAGAAAAAACTTCATCGTGTACATGGGGGAGCTGAGAAAAACCATCCTTTGCAAGAAGAGGAAACCAATCTTCAAAAATCTATCAAAAACGTTCAAGCTAAAAAAGCTATTGTTAAAAGAGCAGCAGAGCTGATTGATAATGGTGATGTGATTTTTGTTGATGCTGGGACAACAACTGCTCTTCTATTGGATCAATTACACGCAGAAGGCTTGACTGTAGTGACGAATTCGATTCATCATGCGGCCAAATTAGTTGAAAAAAATATCAATACGATAATTATTGGTGGTTATGTCAAAAACTCAACAGATGCGAGCATAGGTCAGTTGGCCATTATGCAATTGAGTCAGCTGAATTTTGATAAGGCTTTTGTCGGTATGAATGGTATTGATCATCATTTTTTAACAACGCCTGATACTGAAGAGGCTGTTATCAAAAAGACTGTTATTGACAATGCGCAAGTAACTTATGCTTTGGCAGATGCTTCAAAATTAGGGCAAACATCATTTGTTAAAGTTGATCGGCTAGAAACGGTGACCATTATCACCAACCAATCCGATAATCGGCTGTTAAAGGAAGTAAGAAAAAAGACGAAGGTGATTGAAGTATGA","6.30","-3.11","29388","MGEYIITCVNDFNKEVTLILKSERKQIIMEKLAQENFVTLEFLVGVLDTSESTVRRDLDELASEKKLHRVHGGAEKNHPLQEEETNLQKSIKNVQAKKAIVKRAAELIDNGDVIFVDAGTTTALLLDQLHAEGLTVVTNSIHHAAKLVEKNINTIIIGGYVKNSTDASIGQLAIMQLSQLNFDKAFVGMNGIDHHFLTTPDTEEAVIKKTVIDNAQVTYALADASKLGQTSFVKVDRLETVTIITNQSDNRLLKEVRKKTKVIEV","818493","For other 'fru' genes see SMu0070 (fruA); SMu0071 (fruB);SMu0794 (fruB) and SMu0795 (fruA).For other 'lac' genes see SMu0104 (lacD); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC); SMu1354 (lacX);SMu1355 (lacG); SMu1356 (lacE); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). From Genbank: [gi:125938]The lactose phosphotransferase system is a repressor of the lactose catabolism operon.Galactose-6-phosphate is the inducer. ","lactose phosphotransferase system repressor/transcriptional repressor of the fructose operon","Cytoplasm","Matches in gapped BLAST to lactose phosphotransferase system repressor/ transcriptional repressor of sugar metabolism:residues 21-263 are 31% similar to the protein in S.mutans (gi125938). Residues 19-265 are 57% similar to the protein in S.pneumoniae (gi15902822). Residues 29-265 are 60% similar to the protein from S.pyogenes (gi15674886).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1348 (4e-76).","

InterPro
IPR001034
Domain

Bacterial regulatory protein, DeoR N-terminal
PR00037	$\"[42-56]T$ $\"[56-74]T$	HTHLACR
PF08220	$\"[24-80]T$	HTH_DeoR
SM00420	$\"[24-76]T$	HTH_DEOR
PS51000	$\"[21-76]T$	HTH_DEOR_2
PS00894	$\"[24-58]?$	HTH_DEOR_1

InterPro
IPR014036
Domain

Bacterial regulatory protein, DeoR
PF00455	$\"[94-246]T$	DeoR

InterPro
IPR002173
Family

Carbohydrate kinase, PfkB
PS00583	$\"[36-60]T$	PFKB_KINASES_1
PS00584	$\"[243-256]T$	PFKB_KINASES_2

InterPro
IPR011611
Domain

PfkB
PF00294	$\"[5-293]T$	PfkB

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.20	$\"[4-280]T$	no description
PTHR10584	$\"[5-279]T$	SUGAR KINASE RELATED
PTHR10584:SF37	$\"[5-279]T$	PHOSPHOFRUCTOKINASE(PFK1)

","BeTs to 6 clades of COG1105COG name: Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB)Functional Class: GThe phylogenetic pattern of COG1105 is ------v-Ebrh--gpo----Number of proteins in this genome belonging to this COG is 3","***** IPB002173 (PfkB family of carbohydrate kinases) with a combined E-value of 2.5e-10. IPB002173A 35-50 IPB002173B 242-256","Residues 214-287 are 59% similar to a (KINASE TRANSFERASE COMPLETE PROTEOME) protein domain (PD023180) which is seen in Q9CGY4_LACLA.Residues 1-207 are 45% similar to a (KINASE TRANSFERASE 1-PHOSPHOFRUCTOKINASE) protein domain (PD005753) which is seen in Q9KWK1_STAAU.Residues 210-280 are 41% similar to a (KINASE RIBOKINASE PROTEOME COMPLETE) protein domain (PD291376) which is seen in K1PF_BORBU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 17:19:44 2006","Wed Sep 13 17:19:44 2006","Wed Sep 13 17:19:44 2006","Wed Jan 2 10:39:39 2002","Fri Dec 14 14:01:33 2001","Fri Dec 14 14:01:33 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0794 is paralogously related (blast p-value < 1e-3) to SMu0101, a predicted fructose-1-phosphate kinase and SMu1359, a predicted tagatose-6-phosphate kinase.","Thu Jan 24 16:57:39 2002","","No significant hits to the NCBI PDB database.","SMU.871","","Residues 7 to 293 (E-value = 5.1e-46) place SMu0794 in the PfkB family which is described as pfkB family carbohydrate kinase (PF00294)","Fri Dec 14 14:01:33 2001","24379325","","Benchabane H, Lortie LA, Buckley ND, Trahan L, Frenette M. Inactivation of the Streptococcus mutans fxpC gene confers resistance to xylitol, a caries-preventive natural carbohydrate sweetener.J Dent Res. 2002 Jun;81(6):380-6.PMID: 12097428Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164","de Vos,W.M., Boerrigter,I., van Rooyen,R.J., Reiche,B. andHengstenberg,W.Characterization of the lactose-specific enzymes of thephosphotransferase system in Lactococcus lactisJ. Biol. Chem. 265 (36), 22554-22560 (1990)PubMed: 2125052van Rooijen,R.J., van Schalkwijk,S. and de Vos,W.M.Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactisJ. Biol. Chem. 266 (11), 7176-7181 (1991)PubMed: 1901863","Fri Oct 25 14:20:45 2002","Wed Jan 2 10:54:39 2002","1","","","SMU.871","406" "SMu0795","819399","821366","1968","ATGAAGATTCAGGACTTACTGAACAAGGATGTCATGTTGCTTGACTTGCAGGCAACAACTAAAGAAGCTGCTATTGATGAGATGGTTTCTAAGTTAGTCGAACAAGGTATCGTTACTGATTTTGATACTTTTAAGGCTGGGATCATGAATCGTGAAGTTCAGACTTCAACTGGCCTTGGTGATGGTATTGCTATGCCTCACAGTAAGAATAAGGCTGTAAAGGAAGCAACGGTTCTTTTTGCCAAATCAAATAAAGGTGTTGATTACGAGGCTCTTGATGGTGAACCTGTTGATCTTTTCTTTATGATTGCGGCTCCTGATGGTGCTAATGATACGCATTTAGCAGCTTTGGCTGAATTATCACAATACCTTTTAAAAGACGGCTTTGCTGATAAGTTGCGTCAGGTAACTAATCCTGATGACGTTATCAATCTTTTTAATGCAACAGAAGAAGAAAAGAAAGAAGCGACACCTGCTGCTCCAGTGGCTGATAGCCACGATTTTCTTGTTGCTGTTACAGCCTGTACAACTGGTATTGCTCACACTTATATGGCAGAAGAAGCGCTGAAAAAGCAAGCCGCTGAAATGGGAGTTGGCATCAAGGTTGAAACCAACGGTGCCTCAGGTGTTGGCAATAAATTGACTGCTGATGATATTAAGCGTGCTAAAGGTGTTATTATCGCTGCTGACAAGGCAGTTGAAATGGATCGTTTTAATGGTAAACCTTTGATTTCGCGTCCAGTTGCTGAGGGAATTAAAAAACCTGAAGAATTAATCAATATTATTCTTGATGGTAAAGCTGAAGCCTATGTTGCTGACAACTCTGATCTTAGCAGTGAAGCATCATCAAGTGAAAAAGCTGGTCTTGGAAGTGCCTTCTATAAACACTTGATGAGTGGGGTTTCACAAATGCTTCCATTCGTTATCGGTGGCGGTATCATGATTGCTTTGTCATTCTTGATTGACCAATTCATGGGGGTTCCTAAGTCTTCTCTTAGTCACTTGGGGAATTACCATGAAATTGCAGCTATTTTCAATCAAGTCGGTAATGCTGCTTTTGGCTTTATGATTCCAGTCTTTGCTGCTTATATTGCTTATTCAATTGCTGAAAAGCCAGGTTTGGTAGCTGGTTTTGTAGCTGGCAGTATGGCAACAACAGGTCTTGCTTTCAATAAGGTTGCTTTCTTTGAATTTGGTGAAAAGGCTAGTCAAGCTAGTTTAACTGGTATACCTTCTGGCTTCCTTGGCGCTCTTGCAGGTGGTTTCCTTGCAGGCGGTGTCATTCTTGTCCTCAAGAAAGCCCTTGCCTTTGTACCTCGTTCTCTTGAAGGTATAAAATCCATCCTTCTCTATCCTTTGCTTGGTGTTTTGGTAACTGGTTTCCTCATGCTTTTTGTCAACATTCCAATGGCAGCTATCAATACAGCCTTATATAATTTCCTCGGCAACTTATCAGGTGGTTCAGCAGTTCTTTTAGGACTTATTGTTGGTGGTATGATGGCGATTGATATGGGCGGACCTTTTAATAAAGCAGCCTATGTTTTTGGAACAAGTACTTTAACAGCAGCAGCTCTTGCTAAGGGTGGTTCAGTTGTCATGGCCAGTGTCATGGCTGGTGGTATGGTACCGCCGCTTGCAGTTTTTGTTGCGACTCTTCTTTTTAAAAATAAATTCACTCAAGAAGAACATGATGCTGGTTTAACAAATATTGTTATGGGCCTTTCTTTCATTACTGAAGGTGCCATTCCATTTGGTGCAGGAGACCCAGCACGTGCCATTCCAAGTTTCATTGTTGGTTCAGCGGTTACTGGTGCCTTGGTTGGTTTAAGCGGTATTAAATTAATGGCGCCTCATGGGGGTATCTTTGTTATTGCTTTGACAAGCAATCCTTTGCTTTACCTGCTTTATATTGCTGTTGGAGCAGTGATTGCTGGTATTCTTTTTGGAAGTCTTCGTAAAGTAAGATAA","5.40","-8.84","68222","MKIQDLLNKDVMLLDLQATTKEAAIDEMVSKLVEQGIVTDFDTFKAGIMNREVQTSTGLGDGIAMPHSKNKAVKEATVLFAKSNKGVDYEALDGEPVDLFFMIAAPDGANDTHLAALAELSQYLLKDGFADKLRQVTNPDDVINLFNATEEEKKEATPAAPVADSHDFLVAVTACTTGIAHTYMAEEALKKQAAEMGVGIKVETNGASGVGNKLTADDIKRAKGVIIAADKAVEMDRFNGKPLISRPVAEGIKKPEELINIILDGKAEAYVADNSDLSSEASSSEKAGLGSAFYKHLMSGVSQMLPFVIGGGIMIALSFLIDQFMGVPKSSLSHLGNYHEIAAIFNQVGNAAFGFMIPVFAAYIAYSIAEKPGLVAGFVAGSMATTGLAFNKVAFFEFGEKASQASLTGIPSGFLGALAGGFLAGGVILVLKKALAFVPRSLEGIKSILLYPLLGVLVTGFLMLFVNIPMAAINTALYNFLGNLSGGSAVLLGLIVGGMMAIDMGGPFNKAAYVFGTSTLTAAALAKGGSVVMASVMAGGMVPPLAVFVATLLFKNKFTQEEHDAGLTNIVMGLSFITEGAIPFGAGDPARAIPSFIVGSAVTGALVGLSGIKLMAPHGGIFVIALTSNPLLYLLYIAVGAVIAGILFGSLRKVR","821365","For other 'fru' genes see SMu0070 (fruA); SMu0071 (fruB);SMu0793 (fruR) and SMu0794 (fruB). From Genbank:[gi:1346892]This protein is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system.The IICD domains contain the sugar binding site and the transmembrane channel; the IIA domain contains the primary phosphorylation site (the donor is phospho-HPR); IIA transfers its phosphoryl group to the IIB domain which finally transfers it to the sugar . ","fructose-specific PTS system enzyme IIBC component","Membrane, Cytoplasm","Several matches in gapped BLAST to fructose-specific enzyme II, PTS system BC component: residues 1-653 are 68% similar to the protein in S.pyogenes (gi15674888)and are 67% similar to the protein from S.pneumoniae (gi15902824).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1346 (0.0).","

InterPro
IPR002178
Domain

Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PD001689	$\"[7-141]T$	Q8DUN3_STRMU_Q8DUN3;
G3DSA:3.40.930.10	$\"[1-156]T$	no description
PF00359	$\"[5-149]T$	PTS_EIIA_2
PS51094	$\"[5-149]T$	PTS_EIIA_TYPE_2

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[298-599]T$	PTS_EIIC

InterPro
IPR003353
Domain

Phosphotransferase system, fructose-specific IIB subunit
PF02379	$\"[168-270]T$	PTS_IIB_fruc
TIGR00829	$\"[170-253]T$	FRU: PTS system, Fru family, IIB component

InterPro
IPR004715
Domain

Phosphotransferase system, IIA component fructose subfamily
TIGR00848	$\"[6-133]T$	fruA: PTS system, fructose subfamily, IIA c

InterPro
IPR006327
Domain

Phosphotransferase system, fructose IIC component
TIGR01427	$\"[279-652]T$	PTS_IIC_fructo: PTS system, Fru family, IIC

InterPro
IPR013011
Domain

Phosphotransferase system, EIIB component, type 2
PS51099	$\"[169-264]T$	PTS_EIIB_TYPE_2

InterPro
IPR013014
Domain

Phosphotransferase system, EIIC component, type 2
PS51104	$\"[293-655]T$	PTS_EIIC_TYPE_2

noIPR
unintegrated

unintegrated
tmhmm	$\"[304-324]?$ $\"[343-363]?$ $\"[373-391]?$ $\"[410-430]?$ $\"[451-471]?$ $\"[477-497]?$ $\"[506-526]?$ $\"[532-554]?$ $\"[592-612]?$ $\"[631-651]?$	transmembrane_regions

","BeTs to 4 clades of COG1299COG name: Phosphotransferase system, fructose-specific IIC componentFunctional Class: GThe phylogenetic pattern of COG1299 is --------EB-h--gpO----Number of proteins in this genome belonging to this COG is 2","***** IPB003353 (PTS system, fructose specific IIB domain) with a combined E-value of 6.9e-35. IPB003353 169-218***** IPB002178 (phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) with a combined E-value of 1.1e-06. IPB002178 51-68","Residues 496-647 are 65% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD132278) which is seen in Q9CGY3_LACLA.Residues 48-142 are 29% similar to a (IIA PTS DNA-BINDING COMPLETE) protein domain (PD171762) which is seen in Q9CP84_PASMU.Residues 4-121 are 77% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIA ENZYME COMPLETE) protein domain (PD001689) which is seen in Q9CGY3_LACLA.Residues 48-142 are 30% similar to a (PTSN) protein domain (PD396223) which is seen in Q9L7V4_HAEDU.Residues 295-495 are 60% similar to a (COMPONENT SYSTEM PTS FRUCTOSE-SPECIFIC) protein domain (PD350819) which is seen in Q9CGY3_LACLA.Residues 21-147 are 27% similar to a (COMPONENT IIABC SYSTEM PHOSPHOTRANSFERASE) protein domain (PD346891) which is seen in PTFA_MYCPN.Residues 169-258 are 72% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD004040) which is seen in Q9CGY3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 17:06:46 2006","Wed Jan 2 11:02:41 2002","Wed Aug 30 17:06:46 2006","Wed Jan 2 10:58:20 2002","Fri Dec 14 14:21:18 2001","Fri Dec 14 14:21:18 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0795 is paralogously related (blast p-value < 1e-3) to SMu0102,a predicted PTS system, fructose-specific IIBC component, SMu0103,a predicted PTS system, fructose-specific IIA component, and SMu0279,a predicted sorbitol operon regulator","Mon Jan 14 09:35:43 2002","Wed Aug 30 17:06:46 2006","pdb1A6JB Chain B, Nitrogen Regulatory Bacterial Protein Iia-N... 65 2e-011","SMU.872","","Residues 5 to 149 (E-value = 4.3e-25) place SMu0795 in the PTS_EIIA_2 family which is described as Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PF00359)Residues 168 to 270 (E-value = 3.5e-51) place SMu0795 in the PTS_IIB_fruc family which is described as PTS system, Fructose specific IIB subunit (PF02379)Residues 298 to 599 (E-value = 8.4e-36) place SMu0795 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)","Wed Aug 30 17:06:46 2006","24379326","","Benchabane H, Lortie LA, Buckley ND, Trahan L, Frenette M. Inactivation of the Streptococcus mutans fxpC gene confers resistance to xylitol, a caries-preventive natural carbohydrate sweetener.J Dent Res. 2002 Jun;81(6):380-6.PMID: 12097428Wen ZT, Browngardt C, Burne RA. Characterization of two operons that encode components of fructose-specific enzyme II of the sugar:phosphotransferase system of Streptococcus mutans.FEMS Microbiol Lett. 2001 Dec 18;205(2):337-42.PMID: 11750824Wen ZT, Burne RA. Analysis of cis- and trans-acting factors involved in regulation of the Streptococcus mutans fructanase gene (fruA).J Bacteriol. 2002 Jan;184(1):126-33.PMID: 11741852 ","Reizer,J., Paulsen,I.T., Reizer,A., Titgemeyer,F. and Saier,M.H.Jr.Novel phosphotransferase system genes revealed by bacterial genomeanalysis: the complete complement of pts genes in mycoplasmagenitaliumMicrob. Comp. Genomics 1 (3), 151-164 (1996)PubMed: 9689210Wu,L.F. and Saier,M.H. Jr.Nucleotide sequence of the fruA gene, encoding the fructosepermease of the Rhodobacter capsulatus phosphotransferase system,and analyses of the deduced protein sequenceJ. Bacteriol. 172 (12), 7167-7178 (1990)PubMed: 2254279","Sat Oct 26 16:59:21 2002","Wed Jan 2 11:11:30 2002","1","","","SMU.872","580" "SMu0796","821698","823935","2238","ATGACAAAAGTTTCAAGCTTGGGCTATCCACGTTTAGGAGAAAACCGTGAATGGAAAAAATTAATCGAAGCTTATTGGGCAGGAAAAGTTAGCAAGAATGATTTATTTGCTGGTGCTAAGGAACTGCGTTTAGACTTTTTAAAAAAACAATTGAATGCAGGTCTTGATCTGATTCCAGTGGGGGATTTTTCACTTTATGATCATATTTTGGATTTGTCAGTGCAATTTAATATTATTCCTAAACGCTTTGCTAAAGAGCCAATAGATATCGACTTATATTTTGCTATTGCTCGTGGAAATAAAGAAAATGTTGCTTCTTCAATGAAGAAATGGTTTAACACTAATTATCACTATATTGTTCCCGAATGGTCAAAACAACGACCAAAACTCAATAATAATCGTTTATTGGATCTTTATTTGGAAGCTAGAGAAGTTGTTGGAGATAAGGCTAAGCCTGTTATTACTGGTCCCATTACTTATGTGGCTCTGTCAACAGGCGTTGAAGATTTTACAGCTGCTGTTAAGAGTTTGCTGCCGCTCTACAAGCAAGTTTTTACGGAATTAGTAAAAGCAGGGGCAAGCTATATCCAAGTAGATGAACCTATCTTTGTAACAGATGAAGGTAAAGATTATCTCCAAGCAGCTAAAGCAGTTTATGCTTACTTCGCTAAAGAAGTCCCTGATGCTAAATTTATTTTTCAGACCTATTTTGAAGGTTTGATTGATAGTCAGGTTTTGTCTCAACTTCCAGTAGATGCCTTTGGTCTTGATTTTGTTTATGGTTTGGAGGAAAATCTTGAGGCTATTAAGACGGGTGCTTTTAAAGGCAAAGAAATCTTTGCAGGCGTTATTGATGGACGTAATATCTGGAGTTCTGATTTTGTTAAAACGTCAGCATTGTTAGAGACGATTGAGGAACAATCTGCAGCCCTTACTATTCAGCCTTCTTGTTCACTCTTGCATGTGCCTGTAACAACTAAGAATGAAACAGATTTAGATCCTGTCTTGCGCAATGGATTAGCTTTTGCAGATGAAAAATTAACAGAAGTCAAACGATTGGCTGAGCATTTAGATGGTAGAGAAGATCCAGCTTATGATTTACATATTGCACATTTTGATGCTCTTCAGGCTGCTGATTTTAGAAACGTTAAACTTGAAGATCTAAGTCGTGTTGCGACAAAACGCCCTAGCGACTTTGCTAAACGTCGTGATATTCAGCAAGAGAAGCTGCATTTGCCTTTGCTGCCAACGACAACGATTGGCTCTTTCCCACAATCAAGAGAAATCAGACGGACACGTCTGGCTTGGAAGCGTGGTGATATCAGTGATGCAGAGTATAAACAATTTATTCAGGCTGAAATTGAACGCTGGATTCGTATTCAGGAAGATTTGGATCTTGACGTTTTGGTACATGGTGAATTTGAGCGGGTTGACATGGTTGAATTTTTTGGACAAAAATTAGCCGGTTTTACAACAACAAAATTTGGCTGGGTCCAATCTTATGGTTCTCGTGCTGTGAAGCCTCCAATTATTTACGGAGATGTTCAGCATCTTGAACCAATCACCGTTGAAGAAACAGTTTACGCTCAAAGTCTGACTGATCGTCCTGTAAAAGGTATGCTGACAGGTCCAATTACTATCACCAATTGGTCTTTTGAACGAACAGATATTCCACGCGATCAGTTATTTAATCAAATTGGCTTGGCTATTAAAGATGAAATTAAACTATTGGAAAATGCTGGTATTGCTATCATTCAAGTCGATGAAGCGGCTCTTCGTGAAGGTTTGCCGCTGAGAAAAAGCAAGCAAAAAGCCTATTTAGATGATGCAGTCCATGCCTTTCACATTGCAACCTCTTCAGTTAAGGATGAAACACAGATTCATACACACATGTGTTATTCTAAATTTGATGAAATTATTGATGCTATTCGCGCCTTAGATGCTGATGTTATTTCAATTGAAACCAGCCGCAGCCATGGTGATATTATTGAGTCCTTCGAAACAGCTGTTTATCCATTGGGTATTGGTCTTGGTGTCTACGATATTCACTCTCCGCGTGTACCAACTAAAGAAGAAGTGGTGGCTAATATTGAAAGGCCTTTGCGTCAATTATCGCCAACACAATTCTGGGTTAATCCTGATTGTGGTTTAAAAACGCGTCAAGAACCAGAAACCATTGCTGCTTTGAAGGTTTTAGTTGCTGCAACTAAGGAAGTTCGTCAAAAATTAGGAAACTAA","5.50","-14.43","84133","MTKVSSLGYPRLGENREWKKLIEAYWAGKVSKNDLFAGAKELRLDFLKKQLNAGLDLIPVGDFSLYDHILDLSVQFNIIPKRFAKEPIDIDLYFAIARGNKENVASSMKKWFNTNYHYIVPEWSKQRPKLNNNRLLDLYLEAREVVGDKAKPVITGPITYVALSTGVEDFTAAVKSLLPLYKQVFTELVKAGASYIQVDEPIFVTDEGKDYLQAAKAVYAYFAKEVPDAKFIFQTYFEGLIDSQVLSQLPVDAFGLDFVYGLEENLEAIKTGAFKGKEIFAGVIDGRNIWSSDFVKTSALLETIEEQSAALTIQPSCSLLHVPVTTKNETDLDPVLRNGLAFADEKLTEVKRLAEHLDGREDPAYDLHIAHFDALQAADFRNVKLEDLSRVATKRPSDFAKRRDIQQEKLHLPLLPTTTIGSFPQSREIRRTRLAWKRGDISDAEYKQFIQAEIERWIRIQEDLDLDVLVHGEFERVDMVEFFGQKLAGFTTTKFGWVQSYGSRAVKPPIIYGDVQHLEPITVEETVYAQSLTDRPVKGMLTGPITITNWSFERTDIPRDQLFNQIGLAIKDEIKLLENAGIAIIQVDEAALREGLPLRKSKQKAYLDDAVHAFHIATSSVKDETQIHTHMCYSKFDEIIDAIRALDADVISIETSRSHGDIIESFETAVYPLGIGLGVYDIHSPRVPTKEEVVANIERPLRQLSPTQFWVNPDCGLKTRQEPETIAALKVLVAATKEVRQKLGN","823934","For other 'met' genes see SMu1527 (metB); SMu1492 (metS); SMu1335 (metA) and SMu1430 (metK). From Genbank: [gi:12230278]This protein catalyzes the transfer of a methyl group from5-methyltetrahydrofolate to homocysteine resulting in methionine formation.","5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase","Cytoplasm","Several matches in gapped BLAST to homocysteine methyltransferase;methionine synthase II (cobalamin-independent): residues 3-740 are 50% similar to the enzyme in B.subtilis (gi16078383). Residues 3-742 are 58% similar to the protein from S.aureus (gi15923346).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2049 (0.0).","

InterPro
IPR002629
Domain

Methionine synthase, vitamin-B12 independent
PD004692	$\"[637-733]T$	Methionine_synth
PF01717	$\"[415-738]T$	Meth_synt_2

InterPro
IPR006276
Family

5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
TIGR01371	$\"[7-742]T$	met_syn_B12ind

InterPro
IPR013215
Domain

Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal
PF08267	$\"[3-309]T$	Meth_synt_1

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.210	$\"[16-357]T$ $\"[409-745]T$	G3DSA:3.20.20.210

","BeTs to 11 clades of COG0620COG name: Methionine synthase II (cobalamin-independent)Functional Class: EThe phylogenetic pattern of COG0620 is amtKyqv-eBrh-------N-Number of proteins in this genome belonging to this COG is 2","***** IPB002629 (Methionine synthase, vitamin-B12 independent) with a combined E-value of 3.7e-230. IPB002629A 8-26 IPB002629B 53-73 IPB002629C 107-119 IPB002629D 139-165 IPB002629E 177-207 IPB002629F 281-294 IPB002629G 313-329 IPB002629H 410-445 IPB002629I 461-505 IPB002629J 517-565 IPB002629K 625-658 IPB002629L 675-688 IPB002629M 709-740 IPB002629E 566-596","Residues 8-189 are 52% similar to a (METHIONINE SYNTHASE METHYLTRANSFERASE) protein domain (PD006455) which is seen in METE_BACHD.Residues 415-737 are 40% similar to a (METHIONINE METHYLTRANSFERASE SYNTHASE) protein domain (PD004692) which is seen in METE_NEIMB.Residues 192-304 are 38% similar to a (METHIONINE SYNTHASE METHYLTRANSFERASE) protein domain (PD191524) which is seen in METE_BACHD.Residues 321-414 are 36% similar to a (METHIONINE SYNTHASE METHYLTRANSFERASE) protein domain (PD186546) which is seen in METE_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 16:49:51 2006","Mon May 23 08:23:10 2005","Mon May 23 08:22:24 2005","Wed Jan 2 11:18:53 2002","Wed Jan 2 11:18:53 2002","Wed Jan 2 11:18:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0796 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 11:19:24 2002","","No significant hits to the NCBI PDB database.","SMU.873","","Residues 415 to 738 (E-value = 1.2e-187) place SMu0796 in the Methionine_synt family which is described as Methionine synthase, vitamin-B12 independent (PF01717)","Wed Jan 2 11:18:53 2002","24379327","","","Ravanel,S., Gakiere,B., Job,D. and Douce,R.The specific features of methionine biosynthesis and metabolism inplantsProc. Natl. Acad. Sci. U.S.A. 95 (13), 7805-7812 (1998)PubMed: 9636232","","Wed Jan 2 12:54:17 2002","1","","","SMU.873","491" "SMu0797","823953","825809","1857","ATGTCCAGATTGCTGGATAAACTAAAGACAGATATTTTAGTGGCTGATGGAGCTATGGGGACTCTTCTCTATGCAGATGGTTTAGAATCCTGCCATGAATATTATAATATCAGTCATCCCGAGCGAATTTTGGCTATTCATCAAGCTTATATTGCAGCTGGAGCAGACATCATTCAGACCAATACTTATGGTGCTAAAAGACATCGTTTAAAAAGTTTTGGTCACGATAAAGAAGTTAAGGCAATCAATCAGGCAGCTGTTCATCTGGCCCGTCAGGCAGCTGGTGACAATACCTTTGTTTTAGGAACAATAGGTGCTTCACATGGCCTTAAACATTGTGAACTGTCCTTGGAAGACATTATTTCTCAGACTGTAGAACAGGCTCGGTTTCTTTTGGAAACGAAGCAAATTGATGGTTTGCTCTTAGAGACTTACTATGATATAGAAGAACTTGAGGCTGCTTTAAAGGCCTTGAGGCCTTTAACAGACTTGCCGATCATTACGAATGTTGCCCTTCATGAACCGGGAATTACTGAAAATGGTCGACCTTTAGTGGAAGCTTTTAGTAACTTGGTAATGTTGGGAGCCGATATCGTTGGTTTGAACTGCCATTTGGGACCTTATCATATGATCCAATCTTTCAAGCAAGTACCACTGTTTGCGCAGAGTTATTTATCAGCTTATCCTAATGCCAGTCTGTTATCTTTTTCCAGTGATGATAATGAGACCCCTTACCACTTTAGCCAGAATGCAGACTATTTTGAGTATTGTGCTAAACTTTTTGTTGAAGAAGGGGTCCGCCTCATTGGCGGCTGTTGCGGAACAACTCCTGAACATATCAAAGCTATAAAACGTGGTATTCGAGGACTTAAACCAATTGAGCGAAAAGTGACGACACCTTTGATTAGTCAAGAAGACTTGATTTATGAAGTGGAGAAAAAAGAAAGTCTGGTTGACAAAGTTAAAAAAGGGATCACCATTATTGCTGAAATTGATCCTCCTAAAACCTTGGCCGTTGACAAATTTGTTGATGGTGTCAAAGCCTTAGACGAAAAAGGTATTGCGGCGATTACCTTAGCAGATAATTCTCTTGCTAGAACGCGTATTTGTAATCTCAGCATGGCGTCAATGCTAAAGGATGAGATTGCAACACCTTTCTTACTTCATTTGTCCTGTCGCGATCATAATATGATTGGACTGCAGTCACGCCTTTTGGGCATGGATCTTTTGGGATTTGATCATATTCTTGCCATCACAGGAGATCCCTCAAAAATTGGAGATTTCCCAGGAGCTACCAGTGTTTATGACGCTACCAGTTTCAAATTGCTGTCTTTGATTAAGCAACTCAATCAGGGTCATGGTTACAGCGGTGCTAGTCTTAAAAAAGCGACCCATTTTACCGTTGCTGCGGCTTTTAACCCTAATGTTAAAAACTTAAGCAGAACAGGAAGGTTAATTGAGAAGAAGGTTGCAGCTGGAGCAGATTATTTTATCACACAGCCTGTTTTTAGCGAAACAGTCATACAAGAGTTAAGTGAAGTTACTAAACCTTATGAACAGCCCTTTTTTGTTGGTATTATGCCGATCACTTCTTATAATAATGCTGTTTTCTTACATAATGAAGTTCCGGGAATCAGTTTATCAGAATCTTTTCTGGCAAAATTAGAAGCGGTTAAGGATGATAAAGAAACCTGTCAGAAAGTAGCTTTAGCTGAAAGTAAAAAATTGATAGACGCAATTCTGGCTCATTTTAATGGCATTTATCTCATTACTCCTTTTTTACGTTATGATTTGACAGTAGAATTAATTGATTATATTCAAGTAAAGACAGCAACTGTTGCTAAAAAGAGAACTTAG","6.40","-6.56","68046","MSRLLDKLKTDILVADGAMGTLLYADGLESCHEYYNISHPERILAIHQAYIAAGADIIQTNTYGAKRHRLKSFGHDKEVKAINQAAVHLARQAAGDNTFVLGTIGASHGLKHCELSLEDIISQTVEQARFLLETKQIDGLLLETYYDIEELEAALKALRPLTDLPIITNVALHEPGITENGRPLVEAFSNLVMLGADIVGLNCHLGPYHMIQSFKQVPLFAQSYLSAYPNASLLSFSSDDNETPYHFSQNADYFEYCAKLFVEEGVRLIGGCCGTTPEHIKAIKRGIRGLKPIERKVTTPLISQEDLIYEVEKKESLVDKVKKGITIIAEIDPPKTLAVDKFVDGVKALDEKGIAAITLADNSLARTRICNLSMASMLKDEIATPFLLHLSCRDHNMIGLQSRLLGMDLLGFDHILAITGDPSKIGDFPGATSVYDATSFKLLSLIKQLNQGHGYSGASLKKATHFTVAAAFNPNVKNLSRTGRLIEKKVAAGADYFITQPVFSETVIQELSEVTKPYEQPFFVGIMPITSYNNAVFLHNEVPGISLSESFLAKLEAVKDDKETCQKVALAESKKLIDAILAHFNGIYLITPFLRYDLTVELIDYIQVKTATVAKKRT","825808",""," 5-methyltetrahydrofolate--homocysteine methyltransferase","Cytoplasm","Its nearest neighbor in the NR database is gi:22538183 from Streptococcus agalactiae 2603V/R.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2048 (0.0).","

InterPro
IPR001951
Family

Histone H4
PS00047	$\"[64-68]?$	HISTONE_H4

InterPro
IPR003171
Family

Methylenetetrahydrofolate reductase
PF02219	$\"[313-607]T$	MTHFR

InterPro
IPR003726
Domain

Homocysteine S-methyltransferase
G3DSA:3.20.20.330	$\"[4-300]T$	S_methyl_trans
PF02574	$\"[12-289]T$	S-methyl_trans
PS50970	$\"[1-287]T$	HCY
SSF82282	$\"[1-350]T$	S_methyl_trans

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.220	$\"[322-615]T$	G3DSA:3.20.20.220
PTHR21091	$\"[24-549]T$	PTHR21091
PTHR21091:SF4	$\"[24-549]T$	PTHR21091:SF4
SSF51730	$\"[313-611]T$	SSF51730

","BeTs to 4 clades of COG0685COG name: 5,10-methylenetetrahydrofolate reductaseFunctional Class: EThe phylogenetic pattern of COG0685 is ---kYqvceb-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB003726 (Homocysteine S-methyltransferase) with a combined E-value of 1.2e-30. IPB003726A 40-63 IPB003726B 198-219 IPB003726C 265-277","Residues 6-189 are 48% similar to a (METHYLTRANSFERASE METHIONINE PROTEOME COMPLETE SYNTHASE) protein domain (PD003711) which is seen in Q9KCE2_BACHD.Residues 180-292 are 32% similar to a (METHYLTRANSFERASE ZINC) protein domain (PD023506) which is seen in BHMT_MOUSE.Residues 194-292 are 52% similar to a (METHYLTRANSFERASE METHIONINE SYNTHASE) protein domain (PD335628) which is seen in Q9KCE2_BACHD.Residues 297-516 are 25% similar to a (PROTEOME COMPLETE METH2 PH1091) protein domain (PD132868) which is seen in O58818_PYRHO.Residues 330-606 are 53% similar to a (PROTEOME COMPLETE - 5) protein domain (PD401989) which is seen in O06745_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 17:04:39 2002","Tue Mar 6 11:30:46 2007","Mon May 23 09:17:55 2005","Wed Jan 2 12:59:50 2002","Wed Jan 2 12:59:50 2002","Wed Jan 2 12:59:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0797 is paralogously related (blast p-value < 1e-3) to SMu0864, homocysteine S-methyltransferase.","Thu Jan 24 17:02:15 2002","","No significant hits to the NCBI PDB database.","SMU.874","","Residues 12 to 289 (E-value = 4.1e-65) place SMu0797 in the S-methyl_trans family which is described as Homocysteine S-methyltransferase (PF02574)Residues 313 to 607 (E-value = 7.6e-12) place SMu0797 in the MTHFR family which is described as Methylenetetrahydrofolate reductase (PF02219)","Mon May 23 09:16:13 2005","24379328","","","","","","1","","","SMU.874","" "SMu0798","826466","825849","618","ATGCGTATTCTTGGTCATCACTCACCTATTCGTAAGAAGACGTATCATTCTTGTACTCAACGAGAGATAACTGAAAAGGCAAGACACGTCCACTACAACGTGCTTGCCCGAAACTTTAAAGCAGAACGCCCTCTCCAGAAACTAACAACGGATGTCAGCTACGTTTACTACAACTATGGGAGGATGTTACTGAGTGTCATAAAAGATTGTTATGACAATTCCATTTTAGACTATACGCTATCCGATTTCAATGATAACAAGTTAGTTTTTGATAATATAGATCTTGTATTTAATAATTTCTGGGATTCAACTAAGGTCTGCATTCTTCATTCTGATCAAGGATTTCAATACACCAATCAACAATATCTTCGAAAACTAGACCAATATGGAGTGACCATTTCTCATTCTGGTAAGGGAAATGGTTACGATAATGCAGCCTGTGAGAATTTCTTTTCTCACTTGAAGAGTGAGTCCTTAAGACTATTTCCACCTAAAGACAAGAGAACACTCATCCGTCAAATTAGGGAATACATTAACTGGTATAACTACCACAGACCACAAGAGAAATTAAAAGGTATGACTCCTATGGAATTCAGGAAGCCATACCTTACTAAATAA","10.10","11.97","24513","MRILGHHSPIRKKTYHSCTQREITEKARHVHYNVLARNFKAERPLQKLTTDVSYVYYNYGRMLLSVIKDCYDNSILDYTLSDFNDNKLVFDNIDLVFNNFWDSTKVCILHSDQGFQYTNQQYLRKLDQYGVTISHSGKGNGYDNAACENFFSHLKSESLRLFPPKDKRTLIRQIREYINWYNYHRPQEKLKGMTPMEFRKPYLTK","825854","","transposase, IS861-like","Cytoplasm, Extracellular","Limited matches in gapped BLAST to putative transposase, IS861: residues 1-199 are 36% similar to the enzyme in S.pyogenes (gi15674400)and are 40% similar to the protein from B.thuringiensis (gi1749770).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (2e-25).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[40-200]T$	rve
PS50994	$\"[40-203]T$	INTEGRASE

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[35-195]T$	RNaseH_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.10	$\"[35-196]T$	G3DSA:3.30.420.10

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 134-199 are 50% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in P94597_BACTU.Residues 134-197 are 40% similar to a (TRANSPOSASE) protein domain (PD388723) which is seen in Q45711_BACTU.Residues 53-131 are 36% similar to a (TRANSPOSASE PLASMID) protein domain (PD188994) which is seen in P94597_BACTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:09:02 2002","Tue Sep 26 17:18:53 2006","Tue Sep 26 13:13:31 2006","Wed Jan 2 13:03:41 2002","","Wed Jan 2 13:03:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0798 is paralogously related (blast p-value < 1e-3) to SMu1250, SMu1719, SMu1283, SMu1258, SMu0695, SMu0395, SMu0514, and SMu1236, all predicted transposases .","Thu Jan 24 17:06:10 2002","","No significant hits to the NCBI PDB database.","SMU.875c","","Residues 40 to 200 (E-value = 8.1e-28) place SMu0798 in the rve family which is described as Integrase core domain (PF00665)","Wed Jan 2 13:03:41 2002","24379329","","","Dunn,M.G. and Ellar,D.J.Identification of two sequence elements associated with the geneencoding the 24-kDa crystalline component in Bacillus thuringiensis ssp. fukuokaensis: an example of transposable element archaeologyPlasmid 37 (3), 205-215 (1997)PubMed: 9200224Smith,G.P., Ellar,D.J., Keeler,S.J. and Seip,C.E.Nucleotide sequence and analysis of an insertion sequence fromBacillus thuringiensis related to IS150Plasmid 32 (1), 10-18 (1994)PubMed: 7991668","","Wed Jan 2 13:08:21 2002","1","","","SMU.875c","" "SMu0799","828247","827411","837","ATGAATATTCTAAATATCTATAATGAATTTGATATTAATAATTTCGATTTAAGCGTTGATCACTACGGTTCAGAAAAATGTGATAGAGGCTATTCCTTTGGTCCAACTATTCGAGACAATTATGTCATTCATTTCATCCTTGAAGGTAAAGGAAAACTTACCATAAATCAACACACCCTTGACTTAGCAGCAGGTGATATCTTCCTTCTCCCCAAAGATATCTCAACCTTTTATCAAGCAGATCTCCAAATGCCTTGGAGCTATATCTGGATTGGCTTTAGCGGTTCAAAAGCCGAAAATATTCTTAAGCAGTCAAGCCTTTTTAAACGTTTTTATTGTCATTCTGGCCGCAGCTCCAAGCTCTTCTCACAAATGATGACCATTATTCAATTTGCCAACACCCCCTTAACCTCTGTCAATGAATTACTAATGGTAGGTGAACTTTATAAGCTTTTAGCTGCCCTCATTGAAGAATTTCCTCTATCTCACTTAGAAGAGAGCAATAGCTCAACAAAAGCTTATGTTAACCAAGTGAAAAAAATAATACATTCGCAGTATGGCAGTTCCCTTCGAGTTAATGATATTGCTAAAAAACTGAATCTTAGTCGAAGTTATCTCTATAAAATTTTTAGAAAAAGTACAAATCTTTCCATAAAAGAGTACATACTTCAAGTCAGAATGAAAAGAAGTCAGTATTTGCTTGAAAATCCCAAATTAAGTATTGCTGAAATATCCAATTCTGTTGGTTTTAGCGATTCACTTGCATTTAGTAAAGCCTTTAAAAATTATTTTGGAAAAAGCCCCAGTAAATTTAGAAAAGAAATCCAAAATAATTAA","10.10","10.35","31954","MNILNIYNEFDINNFDLSVDHYGSEKCDRGYSFGPTIRDNYVIHFILEGKGKLTINQHTLDLAAGDIFLLPKDISTFYQADLQMPWSYIWIGFSGSKAENILKQSSLFKRFYCHSGRSSKLFSQMMTIIQFANTPLTSVNELLMVGELYKLLAALIEEFPLSHLEESNSSTKAYVNQVKKIIHSQYGSSLRVNDIAKKLNLSRSYLYKIFRKSTNLSIKEYILQVRMKRSQYLLENPKLSIAEISNSVGFSDSLAFSKAFKNYFGKSPSKFRKEIQNN","827416","For other 'msm' genes see SMu0801 (msmE); SMu0802 (msmF); SMu0803 (msmG); SMu0805 (msmK); SMu1079 (msmK); SMu1428 (msmK); SMu0594 (msmK) and SMu0884 (msmK).","MSM operon regulatory protein","Cytoplasm, Membrane","Matches in gapped BLAST to MSM operon regulatory protein:residues 1-278 are 94% similar to the previously published protein in S.mutans (gi547929). Residues 6-274 are 41% similar to msm operon regulatory protein in S.pneumoniae (gi15901726).Residues 147-278 are 32% similar to the protein in S.pyogenes (gi4033713). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1946 (6e-14).","

InterPro
IPR000005
Domain

Helix-turn-helix, AraC type
PR00032	$\"[241-256]T$ $\"[256-272]T$	HTHARAC
PF00165	$\"[177-223]T$ $\"[229-273]T$	HTH_AraC
SM00342	$\"[189-272]T$	HTH_ARAC
PS00041	$\"[226-268]T$	HTH_ARAC_FAMILY_1
PS01124	$\"[176-274]T$	HTH_ARAC_FAMILY_2

InterPro
IPR003313
Domain

AraC protein, arabinose-binding/dimerisation
PF02311	$\"[18-158]T$	AraC_binding
SSF51215	$\"[2-159]T$	AraC_binding

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[171-224]T$ $\"[225-275]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[171-223]T$ $\"[225-273]T$	Homeodomain-rel

noIPR
unintegrated

unintegrated
PTHR11019	$\"[175-274]T$	PTHR11019
PTHR11019:SF11	$\"[175-274]T$	PTHR11019:SF11

","BeTs to 4 clades of COG2207COG name: AraC-type DNA-binding domain-containing proteinsFunctional Class: KThe phylogenetic pattern of COG2207 is ------vCEBRH---------Number of proteins in this genome belonging to this COG is 3","***** IPB003313 (Arac arabinose-binding and dimerisation domain) with a combined E-value of 7.4e-13. IPB003313E 190-235 IPB003313F 236-276***** IPB000005 (AraC type helix-turn-helix) with a combined E-value of 4.1e-12. IPB000005 241-272","Residues 182-272 are 40% similar to a (TRANSCRIPTION DNA-BINDING REGULATION) protein domain (PD402035) which is seen in LACR_STAXY.Residues 176-265 are 35% similar to a (TRANSCRIPTION REGULATION DNA-BINDING TRANSCRIPTIONAL) protein domain (PD000394) which is seen in RAFR_PEDPE.Residues 7-174 are 91% similar to a (TRANSCRIPTION ACTIVATOR REGULATION) protein domain (PD022198) which is seen in MSMR_STRMU.Residues 190-275 are identical to a (DNA-BINDING TRANSCRIPTION REGULATION TRANSCRIPTIONAL) protein domain (PD385094) which is seen in MSMR_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 13 13:47:10 2007","Wed Jan 2 13:11:15 2002","Tue Mar 13 13:47:10 2007","Wed Jan 2 13:11:15 2002","Wed Jan 2 13:11:15 2002","Wed Jan 2 13:11:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0799 is paralogously related (blast p-value < 1e-3) to SMu0893 and SMu0263,both predicted transcriptional regulators,and to SMu0745,a predicted,DNA primase.","Mon Jan 14 08:19:11 2002","","No significant hits to the NCBI PDB database.","SMU.876c","","Residues 18 to 158 (E-value = 1.2e-35) place SMu0799 in the AraC_binding family which is described as AraC-like ligand binding domain (PF02311)Residues 177 to 223 (E-value = 6.2e-12) place SMu0799 in the HTH_AraC family which is described as Bacterial regulatory helix-turn-helix proteins, araC family (PF00165)Residues 229 to 273 (E-value = 4.2e-12) place SMu0799 in the HTH_AraC family which is described as Bacterial regulatory helix-turn-helix proteins, araC family (PF00165)","Tue Mar 13 13:47:10 2007","","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 1537846Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890Cote,C.K., Cvitkovitch,D., Bleiweis,A.S. and Honeyman,A.L.A novel beta-glucoside-specific PTS locus from streptococcus mutans that is not inhibited by glucoseMicrobiology 146 (Pt 7), 1555-1563 (2000)PubMed: 10878120Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248","Bassias,J. and Bruckner,R.Regulation of lactose utilization genes in Staphylococcus xylosusJ. Bacteriol. 180 (9), 2273-2279 (1998)PubMed: 9573174","Tue Mar 26 15:12:58 2002","Mon Jan 14 08:14:56 2002","1","","","SMU.876c","" "SMu0800","828355","830517","2163","ATGGGCATTGTTATTAAAGATAACCTTTTTTATATACACACCAAAGACTCATCATTGATTATTGAAGAAAGAGATGGTGATTTGCTTTTAAAACATCTAGGTAAAAAAATTGAAGCCTATCATTTTTCCAATACTGTTTTTGAAAAGGATCATGCTTTTTCAGCTAATCCAGTGGCGGACAATAGAAATTATAGTTATGATACACAAAGACAAATATTTGGTGTTCATGGTTTTGGTGATTTTAGAGTGCCTTCACTAATCCTTCAACATGATAATAATGATTTAACACGGTTTAAATTTAAGAAGGCTAAAATTATTAAGGGGGGGATCAAGGCAAGAGGTTTGCCTAATCCACATAGCAGTGAGAGTGCTCAAAGCTTGGCTCTTATCTTAGAAGATGATTTGGCAAAACTGCGCATGACTCTGTATTATACGGCTTATGATGATAATGCCACCATTTCAACCTTTGTCAAATTTGAAAATTTATCTGATAAGCCTGTTATTCTTCATCGTGCTTTATCAACAATGTTTGATTTACCTGCCAGCCATTATGATGTGATAACTTTTCAAGGAGCTTATGCTCGCGAGAAGACGCTTCGGCGCCACCAGATTGAACAGGGTCTGTTTAAAATAGGCTCTAATCGAGGAGCTTCAGGACATGCTCAAACCCCTTCCTTAATTTTAACAGAGCATGATAGCAATGAGTTTTATGGAGAGGCTTTGGCTTTACAATTAATCTATAGCGGAAATTTTCAAGCTTTTGTTCAAAAAAATCAATTAAACGAGGTTCGCTTAGGCATCGGAATAAATGATGATAATTTTTCATGGGACCTGCAGGCTAATCAGAGTTTTGAGACACCTGTAGCTTTGATAACCTACACTGATAAGGGATTAACGGATCTGACACAAGAAAGTCATAATTTTATTAAACGTCATATTATTCCTAAGAATTTTGCTAATAAGGAACGTCCTATCCTTATCAATAATTGGGAGGCAACATATTTTGATTTTAATCGGAGTCAATTGCTGGGGCTGGCAGATGAAGCCAGAAAACTTGGCATTGAACTCTTTGTGCTTGACGATGGTTGGTTTGGTCATCGTTTTGATGACAATAGCTCACTTGGTGATTGGTTTGTCAATGAAGAAAAACTTGGGGGTTCCCTTGATAGCTTTATCAAGGAAATTCATGATAGAGGATTACAGTTCGGCCTTTGGTTTGAACCAGAAATGGTATCAGTTGACAGCAAACTTTATAGAGCTCATCCTGATTGGGTCATTCAGGCAGATCAGCGAGAGCATACTTATTCTCGCAATCAATTGGTCTTGAATCTAGCTAATCCCGATGTAGTTGCTTATATCAAAACTGTTCTTGATAAGCTGCTGACAGAAAATACGATTGATTATGTTAAATGGGACTACAATCGCAATATAACCAATATTGGCAATGGCAGAACTTACTTGGAAACGCAAATGCAGTCGCATGCTTATATACTGGGGTTGTATAATATTGTTTCTTACTTAACAACAAAACACGATAAGGTCTTGTTTGAATCCTGTTCAGGAGGTGGCGGTCGCAACGATTTGGGGATGATGTGTTATTTTCCTCAAGTGTGGTCAAGTGATAATACAGATGCTATTGCAAGACTGCCTATACAGTATGGTTCCTCTTATCTTTACCCAACTATTTCTATGGGAGCTCATGTTTCAGCGGTTCCTAACCATCAAATGAACCGTCATACCCCTCTTACAACACGAGGTCATGTTGCTATGATGGGAAATTTAGGTTATGAATTGGACTTAGCAATCTTAACCAAAAATGAAAAAAAGGCTGTTGCCAATCAGATTAAACATTATAAAAAGATAAGGTCTGTTGTACAATTTGGCAAGCTTTACCGTCTAATTAATCCCGAAGTTGGAATTAATGAGGTAGCAGTGCAATATACCTATGACAATCAGGTACTGGTTACCTATGTCCGTATTCAATCAACCATAGAGATGATGGAAACAACTGTAAAGTTGAGGGGACTAGATGCAGATGCCATTTATGTTCTTATAGAAACTGGACAAATCTTTTCAGGTGCGGAGTTAATGTATGCGGGATTGACCATTGATATGCCGCAAGGTGATTATTTGAGTAAACAATACTATTTTATTAAAAAGTAG","6.60","-5.02","82134","MGIVIKDNLFYIHTKDSSLIIEERDGDLLLKHLGKKIEAYHFSNTVFEKDHAFSANPVADNRNYSYDTQRQIFGVHGFGDFRVPSLILQHDNNDLTRFKFKKAKIIKGGIKARGLPNPHSSESAQSLALILEDDLAKLRMTLYYTAYDDNATISTFVKFENLSDKPVILHRALSTMFDLPASHYDVITFQGAYAREKTLRRHQIEQGLFKIGSNRGASGHAQTPSLILTEHDSNEFYGEALALQLIYSGNFQAFVQKNQLNEVRLGIGINDDNFSWDLQANQSFETPVALITYTDKGLTDLTQESHNFIKRHIIPKNFANKERPILINNWEATYFDFNRSQLLGLADEARKLGIELFVLDDGWFGHRFDDNSSLGDWFVNEEKLGGSLDSFIKEIHDRGLQFGLWFEPEMVSVDSKLYRAHPDWVIQADQREHTYSRNQLVLNLANPDVVAYIKTVLDKLLTENTIDYVKWDYNRNITNIGNGRTYLETQMQSHAYILGLYNIVSYLTTKHDKVLFESCSGGGGRNDLGMMCYFPQVWSSDNTDAIARLPIQYGSSYLYPTISMGAHVSAVPNHQMNRHTPLTTRGHVAMMGNLGYELDLAILTKNEKKAVANQIKHYKKIRSVVQFGKLYRLINPEVGINEVAVQYTYDNQVLVTYVRIQSTIEMMETTVKLRGLDADAIYVLIETGQIFSGAELMYAGLTIDMPQGDYLSKQYYFIKK","830516","","alpha-galactosidase (melibiase)","Cytoplasm, Extracellular","Matches in gapped BLAST to alpha-galactosidase: residues 1-719 are93% similar to the previously published enzyme in S.mutans (gi|543782|).Residues 1-719 are 63% similar to the enzyme from S.pneumoniae (gi|15903755|).SMu0800 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000111
Family

Glycoside hydrolase, clan GH-D
PF02065	$\"[283-679]T$	Melibiase
PS00512	$\"[353-368]T$	ALPHA_GALACTOSIDASE

InterPro
IPR002252
Family

Glycoside hydrolase, family 36
PR00743	$\"[235-250]T$ $\"[286-306]T$ $\"[324-338]T$ $\"[352-367]T$ $\"[402-424]T$ $\"[460-475]T$ $\"[513-529]T$ $\"[538-554]T$	GLHYDRLASE36
PIRSF005536	$\"[1-720]T$	Agal

noIPR
unintegrated

unintegrated
SSF51445	$\"[312-628]T$	SSF51445

","BeTs to 3 clades of COG1649COG name: Uncharacterized BCRFunctional Class: SThe phylogenetic pattern of COG1649 is -------Ceb-----------Number of proteins in this genome belonging to this COG is 1","***** IPB000111 (Glycosyl hydrolase clan GH-D) with a combined E-value of 1.8e-36. IPB000111A 281-301 IPB000111B 353-363 IPB000111C 371-413 IPB000111D 454-476","Residues 313-473 are 29% similar to a (ALPHA-GALACTOSIDASE GLYCOSIDASE HYDROLASE) protein domain (PD147003) which is seen in Q9X6D2_THETH.Residues 327-403 are identical to a (ALPHA-GALACTOSIDASE GLYCOSIDASE HYDROLASE) protein domain (PD002572) which is seen in AGAL_STRMU.Residues 10-96 are 86% similar to a (ALPHA-GALACTOSIDASE GLYCOSIDASE HYDROLASE) protein domain (PD332170) which is seen in AGAL_STRMU.Residues 115-326 are 96% similar to a (NAD MAGNESIUM MELIBIASE GLYCOSIDASE) protein domain (PD400536) which is seen in AGAL_STRMU.Residues 61-338 are 34% similar to a (ALPHA-GALACTOSIDASE GLYCOSIDASE HYDROLASE) protein domain (PD014287) which is seen in AGA1_PEDPE.Residues 405-701 are 97% similar to a (ALPHA-GALACTOSIDASE GLYCOSIDASE HYDROLASE) protein domain (PD014288) which is seen in AGAL_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 17:11:14 2002","Sat Oct 12 12:10:54 2002","Sat Oct 12 12:10:54 2002","Wed Jan 2 13:55:17 2002","Wed Jan 2 13:55:17 2002","Wed Jan 2 13:55:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0800 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 13:56:30 2002","","No significant hits to the NCBI PDB database.","SMU.877","","Residues 283 to 679 (E-value = 1.1e-273) place SMu0800 in the Melibiase family which is described as Melibiase (PF02065)","Wed Jan 2 13:55:17 2002","24379331","","Aduse-Opoku,J., Tao,L., Ferretti,J.J. and Russell,R.R.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137 (Pt 4), 757-764 (1991)PubMed: 1649890Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267, 4631-4637 (1992)PubMed: 1537846Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248","Janz,L., Ganter,C., Stezowski,J. and Mattes,R.Elucidation of functional domains in thermostable isoenzymes ofalpha-galactosidase in Bacillus stearothermophilus. Enzymaticproperties are encoded in a genetically exchangeable domain(in) Reuss,M., Chmiel,H., Gilles,E.-D. and Knackmuss,H.-J. (Eds.);BIOCHEMICAL ENGINEERING, STUTTGART: 170-173;(1991)Aslanidis,C., Schmid,K. and Schmitt,R.Nucleotide sequences and operon structure of plasmid-borne genesmediating uptake and utilization of raffinose in Escherichia coliJ. Bacteriol. 171 (12), 6753-6763 (1989)PubMed: 2556373Schmid,K. and Schmitt,R.Raffinose metabolism in Escherichia coli K12. Purification andproperties of a new alpha-galactosidase specified by atransmissible plasmidEur. J. Biochem. 67 (1), 95-104 (1976)PubMed: 786627","Tue Mar 26 15:21:05 2002","Wed Jan 2 14:03:40 2002","1","","","SMU.877","" "SMu0801","830530","831792","1263","ATGAAATGGTATAAAAAAATTGGATTACTAGGTATTGTCGGTCTGACGAGCGTCTTACTAGCTGCATGCAACAAAAGTAAGGCTTCGCAGTCAAAGGAGGATAAAGTAACAATTGAGTATTTTAACCAAAAAAAAGAAATGGACGCTACCTTGAAAAAGATAATTAAGGACTTTGAAAGGGAAAATCCTAAAATTCATGTCAAGATGACTAGTGTTCCAGATGCTGGTACAGTCCTCAAAACGCGTGTCTTATCAGGAGATGTGCCCGATGTTATCAATATTTATCCTCAAAATATGGACTTCCAAGAATGGTCCAAAGCAGGTTATTTTTATAATATGACGGGTAAAGCCTATCTTAACCATTTAAAGAATCATTATGCTAACGAATATAAAGTTAATCAAAAGGTTTACAGCGTCCCGTTAACAGCTAATGTTTCAGGAATTTATTATAACAAGACCAAATTTAAAGAATTAGGTTTGAAGGTTCCTGAAACTTGGGATGAGTTTGTTAAATTGGTTGAAGAAATCAAAGCAAAAAAGGAAACACCGTTTGCTTTAGCGGGAACAGAAGGTTGGACCTTGAATGGTTATCATCAGTTATCCTTGATTTCAGTCACTGGCAGTGCTAATGCCGCTAATAAATACCTTCGCTTTTCCCAACCAAATTCGATTAAAACCAGTGATAAAATTTTAAAAGAAGATATGGTTCGGCTCAATCTTTTAGCAGATGATGGCAATCAGCAGAAAAATTGGAAGGGAGCTTCTTATAATGATGCTCTTGTGGCATTTGCTAATGAAAAAGCTCTTATGACACCTAATGGTTCGTGGGCCTTGCCAGCTATTAAACAACAAGATCCCAAATTTGAAATTGGAACCTTTGCTTTTCCGGGCAAAAAAACTGGAAATGGCATAACAGTTGGAGCCGGAGATTTAGCTCTATCAATTTCAGCTAAAACAAAACATCTTAAAGAAGCTGAAAAATTTGTTAAATACATGACGACTGCTAGGGCGATGCAGAAATATTATGATGTTGATGGTTCACCAGTAGCAGTAAAAGGAGTCAGAGAAGATAAGAATTCACCTTTGCAACCTTTAACTAAATTAGCTTTTACTGATAAACACTATGTGTGGTTAGGTCAGCATTGGAATAGTGAAGATGATTTCTTTACAGCCACAACCAATTATCTAATGACAAAAAATGCTAAAGGTTTAGCTGATGGGCTTAACGCTTTCTTTAATCCAATGAAAGCAGACGTTGATTAG","10.10","14.65","47076","MKWYKKIGLLGIVGLTSVLLAACNKSKASQSKEDKVTIEYFNQKKEMDATLKKIIKDFERENPKIHVKMTSVPDAGTVLKTRVLSGDVPDVINIYPQNMDFQEWSKAGYFYNMTGKAYLNHLKNHYANEYKVNQKVYSVPLTANVSGIYYNKTKFKELGLKVPETWDEFVKLVEEIKAKKETPFALAGTEGWTLNGYHQLSLISVTGSANAANKYLRFSQPNSIKTSDKILKEDMVRLNLLADDGNQQKNWKGASYNDALVAFANEKALMTPNGSWALPAIKQQDPKFEIGTFAFPGKKTGNGITVGAGDLALSISAKTKHLKEAEKFVKYMTTARAMQKYYDVDGSPVAVKGVREDKNSPLQPLTKLAFTDKHYVWLGQHWNSEDDFFTATTNYLMTKNAKGLADGLNAFFNPMKADVD","831791","For other components see SMu0805 (NBD1); SMu0802 (MSD1) and SMu0803 (MSD2).For other 'msm' genes see SMu0799 (msmR); SMu0802 (msmF); SMu0803 (msmG); SMu0805 (msmK); SMu1079 (msmK); SMu1428 (msmK); SMu0594 (msmK) and SMu0884 (msmK).From Genbank:[gi:547925]This protein is involved in a binding protein-dependent transport system,responsible for the uptake of melibiose, raffinose and isomaltotriose .","ABC transporter, sugar-binding protein","Membrane, Periplasm, Extracellular","Matches in gapped BLAST to sugar-binding protein msmE: residues 1-419 are 96% similar to the previously published protein in S.mutans (gi547925).Residues 1-419 are 60% similar to the protein from S.pneumoniae (gi15903754).Residues 1-416 are 29% similar to the protein fromClostridium acetobutylicum (gi15896904).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0034 (5e-09).","

InterPro
IPR006059
Family

Bacterial extracellular solute-binding protein, family 1
PF01547	$\"[8-339]T$	SBP_bac_1

InterPro
IPR006061
Domain

Bacterial extracellular solute-binding family 1
PS01037	$\"[140-157]T$	SBP_BACTERIAL_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[146-358]T$	G3DSA:3.40.190.10
PS51257	$\"[1-23]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[22-418]T$	SSF53850

","BeTs to 7 clades of COG1653COG name: Sugar-binding periplasmic proteins/domainsFunctional Class: GThe phylogenetic pattern of COG1653 is ---K--VCEBR------l---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 5-341 are 24% similar to a (PROTEOME COMPLETE EXTRACELLULAR) protein domain (PD230115) which is seen in Q9KKR8_VIBCH.Residues 166-360 are 26% similar to a (ABC TRANSPORTER YURO LIPOPROTEIN) protein domain (PD115171) which is seen in YURO_BACSU.Residues 1-165 are 98% similar to a (COMPLETE PROTEOME SUGAR TRANSPORT) protein domain (PD001485) which is seen in MSME_STRMU.Residues 243-337 are 35% similar to a (SUGAR-BINDING SECRETED SOLUTE-BINDING) protein domain (PD207616) which is seen in Q9FBS5_STRCO.Residues 166-419 are 95% similar to a (TRANSPORT SUGAR-BINDING MULTIPLE MEMBRANE) protein domain (PD118652) which is seen in MSME_STRMU.Residues 48-333 are 22% similar to a (SC2H4.13C) protein domain (PD207609) which is seen in O86596_STRCO.Residues 135-302 are 23% similar to a (BINDING EXTRACELLULAR) protein domain (PD285598) which is seen in Q9S1S7_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:44:04 2007","Thu Sep 28 08:53:45 2006","Thu Sep 28 08:53:45 2006","Wed Jan 2 14:32:16 2002","","Wed Jan 2 14:32:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0801 is paralogously related (blast p-value < 1e-3) to SMu1425, a predicted maltose/maltodextrin-binding protein.","Fri Jan 25 08:08:23 2002","","No significant hits to the NCBI PDB database.","SMU.878","","Residues 8 to 339 (E-value = 9.3e-53) place SMu0801 in the SBP_bac_1 family which is described as Bacterial extracellular solute-binding protein (PF01547)","Wed Jan 2 14:32:16 2002","24379332","","Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267, 4631-4637 (1992)PubMed: 1537846Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:44:04 2007","","1","","","SMU.878","" "SMu0802","831805","832677","873","ATGACTATCAGAAAAGTTTTAAATAAATACTGGGGTTGGACATTTTTAATCGTACCGCTCATTTTACAAGTTGTATTCTTTTATTTTCCTATGTTTCAGGGTGCTTTTTATAGCTTTACTAATTGGACAGGTCTGACCTATAATTTTGATTTTGTTGGTATTAATAATTATAAGATTTTGATGACTGATGGGAAATTTATGAAGGCTATTGGTTTTACTTTGGTTTTGACTCTGGCCTTGATTGTCGGTGAAATTGTCCTTGGTATTATCATTGCACGTGCGCTTAATGCTAAGATCAAAGGAAAAACTTTTTTCAGAGCCTGGTTCTTCTTTCCAGCTGTTTTATCTGGTTTGACAGTTTCTTTGATTTTTAAACAGGTTTTCAATTATGGTTTGCCAGCAGTTGGCAGTGCTTTGGGAATTAAATTTTTAGAAACAAGTATGTTGGGAACAGCGAACGGGGCGGTTATTGCTTCAATCTTTGTTCTTTTGTGGCAAGGTGTTGCTATGCCTATTATTCTTTTCCTTTCAGGATTACAGAGTATTCCATCAGAGATTGTCGAAGCAGCAGCTATTGATGGTGCTGACAGTAAACAGACATTTTGGTCAGTCGAGTTGCCCTACTTACTGCCAAGTATTTCCATGGTTTTCATCATGGCTTTAAAAGCTGGTCTTACGGCCTTTGATCAAATCTTTGCCTTAACAGGTGGCGGTCCAAATAATTCAACAACATCATTAGGCCTTTTGGTTTATAACTATGCCTTTAAGAGTAATCAGTATGGTTATGCTAATGCTATTGCTTTGATTTTATTCATTATCATTGGAATTGTTTCTGTGCTGCAAATTAAACTCTCTAAGAAGTTTGAAGTTTAG","10.40","7.98","31903","MTIRKVLNKYWGWTFLIVPLILQVVFFYFPMFQGAFYSFTNWTGLTYNFDFVGINNYKILMTDGKFMKAIGFTLVLTLALIVGEIVLGIIIARALNAKIKGKTFFRAWFFFPAVLSGLTVSLIFKQVFNYGLPAVGSALGIKFLETSMLGTANGAVIASIFVLLWQGVAMPIILFLSGLQSIPSEIVEAAAIDGADSKQTFWSVELPYLLPSISMVFIMALKAGLTAFDQIFALTGGGPNNSTTSLGLLVYNYAFKSNQYGYANAIALILFIIIGIVSVLQIKLSKKFEV","832676","For other components see SMu0805 (NBD1); SMu0803 (MSD2) and SMu0801 (SBP1).For other 'msm' genes see SMu0799 (msmR); SMu0801 (msmE); SMu0803 (msmG); SMu0805 (msmK); SMu1079 (msmK); SMu1428 (msmK); SMu0594 (msmK) and SMu0884 (msmK).From Genbank: [gi:547926]This protein is involved in a binding protein-dependent transport system responsible for the uptake of melibose, raffinose and isomaltotriose.","ABC transporter, sugar permease protein","Membrane, Cytoplasm","Matches in gapped BLAST to multiple sugar-binding transport system permease protein MsmF: residues 1-290 are 90% similar to a previously published protein in S.mutans (gi547926).Residues 2-290 are 67% similar to the protein from S.pneumoniae (gi15903753).Residues 3-290 are 47% similar to the protein from Clostridium acetobutylicum (gi15896903).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0035 (1e-32).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[66-288]T$	BPD_transp_1
PS50928	$\"[70-281]T$	ABC_TM1

","BeTs to 8 clades of COG1175COG name: ABC-type sugar transport systems, permease componentsFunctional Class: GThe phylogenetic pattern of COG1175 is --TK--VCEBR---gp-l---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 177-264 are identical to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in MSMF_STRMU.Residues 13-57 are 44% similar to a (SUGAR TRANSPORT PROTEOME COMPLETE) protein domain (PD189540) which is seen in O86595_STRCO.Residues 8-60 are 98% similar to a (TRANSPORT TRANSMEMBRANE PERMEASE) protein domain (PD189543) which is seen in MSMF_STRMU.Residues 171-213 are 53% similar to a (TRANSPORT TRANSMEMBRANE PERMEASE COMPLETE PROTEOME SUGAR) protein domain (PD000120) which is seen in Q9KDU3_BACHD.Residues 61-176 are 87% similar to a (TRANSPORT SUGAR-BINDING MULTIPLE MSMF) protein domain (PD395891) which is seen in MSMF_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:44:36 2007","Thu Sep 28 08:57:07 2006","Thu Sep 28 08:57:07 2006","Wed Jan 2 14:54:33 2002","","Wed Jan 2 14:54:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0802 is paralogously related (blast p-value < 1e-3) to SMu1426 and SMu1427, both predicted maltose/maltodextrin ABC transporter; SMu0885 and SMu0886,both predicted spermidine/putrescine ABC transporter (permease protein); SMu0803,a predicted multiple sugar-binding transport system permease protein MsmG;and SMu1039, a predicted phosphate ABC transporter (permease protein).","Fri Jan 25 08:26:00 2002","","No significant hits to the NCBI PDB database.","SMU.879","","Residues 66 to 288 (E-value = 2.9e-32) place SMu0802 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Jan 2 14:54:33 2002","24379333","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 1537846Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:44:36 2007","","1","","","SMU.879","" "SMu0803","832692","833525","834","ATGAAAAAAGAAGAAAAAATAAATTATTTTTGGAAATATGTACTTTTGACTGTTGGTGGCATCCTGATTTTGATCCCACTGATGGTTACTGTCTTTAGCTCTTTTAAGAAAACTAAGGATATTATGAATCATTTTTTTGCCTTTCCAAATCCTATCACCTTGGATAATTACAAACGTTTGTTAGCTGATGGTGTTGGAGGCTATTTTTGGAATTCAACGGTGATTACTGTTTTATCCGTTTTGGTGGTCATGCTCTTTATCCCTGCAGCGGCTTATTCCATTGCGCGTAACATGTCTAGAAGAAAAGCTTTCAATATCATGTATAGCCTGTTGATTCTGGGAATTTTCGTTCCTTTCCAGGTTATCATGATTCCTATTACGGTTATGATGAGTAAATTAGGCCTGGCTAATATGTGGGGATTAATTATTCTGTATTTAACTTATGCTATTCCACAGACACTCTTCCTTTACGTGGGTTATATCAAACTAAGTGTACCTGATAGTTTAGATGAAGCAGCTGAAATTGATGGTGCGGATAAATTGACAACTTATCGTAAAATCATTTTCCCTATGTTAAAACCAATGCACGCAACAACTCTGATTATTAATGCACTTTGGTTCTGGAACGACTTTATGTTGCCATTGCTGATTCTTAATAAGGATTCAAGTATGTGGACGCTTCCTCTTTTCCAATACAATTATAGCGGACAATATTTCAATGATTACGGTCCTAGTTTTGCTTCTTACATTGTTGGTATTATTACCATTACAATTGTTTATCTTATTTTCCAAAAACACATTATTGCTGGTATGAGCAATGGAGCTGTGAAGTGA","10.30","8.70","31641","MKKEEKINYFWKYVLLTVGGILILIPLMVTVFSSFKKTKDIMNHFFAFPNPITLDNYKRLLADGVGGYFWNSTVITVLSVLVVMLFIPAAAYSIARNMSRRKAFNIMYSLLILGIFVPFQVIMIPITVMMSKLGLANMWGLIILYLTYAIPQTLFLYVGYIKLSVPDSLDEAAEIDGADKLTTYRKIIFPMLKPMHATTLIINALWFWNDFMLPLLILNKDSSMWTLPLFQYNYSGQYFNDYGPSFASYIVGIITITIVYLIFQKHIIAGMSNGAVK","833524","For other components see SMu0805 (NBD1); SMu0802 (MSD1) and SMu0801 (SBP1).For other 'msm' genes see SMu0799 (msmR); SMu0801 (msmE); SMu0802 (msmF); SMu0805 (msmK); SMu1079 (msmK); SMu1428 (msmK); SMu0594 (msmK) and SMu0884 (msmK).From Genbank: [gi:547927]This protein is involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose.","multiple sugar-binding transport system permease protein MsmG","Membrane, Cytoplasm","Matches in gapped BLAST to multiple sugar-binding transport system permease protein MsmG: residues 1-277 are 85% similar to the previously published protein in S.mutans (gi547927).Residues 1-277 are 68% similar to the protein in S.pneumoniae (gi15903752).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1443 (6e-18).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[69-273]T$	BPD_transp_1
PS50928	$\"[69-263]T$	ABC_TM1

","BeTs to 8 clades of COG0395COG name: Sugar permeasesFunctional Class: GThe phylogenetic pattern of COG0395 is --TK--VCEBR---gp-l---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 70-147 are 84% similar to a (TRANSPORT TRANSMEMBRANE PERMEASE SUGAR) protein domain (PD330158) which is seen in MSMG_STRMU.Residues 165-267 are 38% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in Q9RJV6_STRCO.Residues 47-153 are 29% similar to a (TRANSPORT SUGAR MEMBRANE) protein domain (PD332866) which is seen in Q9L025_STRCO.Residues 165-217 are 43% similar to a (BINDING DEPENDENT TRANSPORT) protein domain (PD385676) which is seen in Q9RJA2_STRCO.Residues 156-194 are identical to a (TRANSPORT TRANSMEMBRANE PERMEASE COMPLETE PROTEOME SUGAR) protein domain (PD000120) which is seen in MSMG_STRMU.Residues 1-69 are 79% similar to a (TRANSPORT SUGAR-BINDING MULTIPLE MSMG) protein domain (PD079689) which is seen in MSMG_STRMU.Residues 212-277 are 78% similar to a (TRANSPORT PERMEASE SUGAR PROTEOME) protein domain (PD001620) which is seen in MSMG_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:45:18 2007","Wed Jan 2 14:59:18 2002","Tue Apr 24 10:45:18 2007","Wed Jan 2 14:59:18 2002","","Wed Jan 2 14:59:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0803 is paralogously related (blast p-value < 1e-3) to SMu1426 and SMu1427, both predicted maltose/maltodextrin ABC transporter; SMu0802,a predicted multiple sugar-binding transport system permease protein MsmF; and SMu0885,predicted spermidine/putrescine ABC transporter.","Fri Jan 25 08:30:29 2002","","No significant hits to the NCBI PDB database.","SMU.880","Wed Jan 2 15:00:45 2002","Residues 69 to 273 (E-value = 5.1e-28) place SMu0803 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Jan 2 14:59:18 2002","24379334","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 1537846Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:45:18 2007","","1","","","SMU.880","" "SMu0804","833680","835125","1446","ATGCCAATTATAAATAAAACAATGTTGATTACTTACGCAGACAGTTTGGGTAAAAATTTGAAAGAATTGAATGAAAATATTGAGAATTATTTTGGAGATGCTGTTGGCGGTGTCCATTTGCTGCCATTCTTTCCTTCCACAGGTGATCGTGGCTTTGCACCGATTGATTACCATGAAGTTGACTCTGCTTTTGGCGATTGGGATGATGTCAAATGCTTGGGTGAAAAATATTACCTCATGTTTGATTTCATGATTAATCATATTTCGCGTCAGTCTAAATATTATAAAGATTACCAAGAAAAGCATGAAGCAAGTGCTTATAAAGATCTATTTTTAAATTGGGATAAATTTTGGCCTAAAAATCGCCCGACACAAGAAGATGTGGACCTGATTTATAAGCGTAAGGATCGAGCACCTAAGCAGGAAATCCAATTTGCAGATGGCAGTGTTGAACATCTCTGGAACACTTTTGGGGAGGAACAGATTGATCTTGACGTGACTAAAGAAGTGACTATGGATTTTATTCGCTCTACCATTGAAAATTTAGCAGCCAACGGCTGTGATCTCATTCGTTTGGATGCCTTTGCTTATGCTGTTAAAAAGCTAGATACGAATGATTTCTTTGTTGAACCTGAAATCTGGACTCTGCTAGATAAAGTTCGTGATATAGCTGCTGTATCGGGTGCGGAAATCTTGCCGGAAATTCATGAACACTATACTATTCAATTTAAAATTGCAGACCATGATTACTATGTTTATGATTTTGCCCTGCCTATGGTGACGCTCTACAGCCTATATTCGAGCAAGGTTGACCGTCTTGCCAAATGGCTGAAAATGAGTCCGATGAAACAGTTCACCACCCTTGATACACATGACGGTATTGGTGTGGTTGATGTTAAGGATATCCTGACTGACGAAGAAATTACCTATACTTCTAATGAGCTTTATAAGGTCGGTGCCAATGTCAATCGTAAGTATTCAACTGCCGAATATAATAACTTGGATATCTATCAAATTAATTCAACTTACTATTCAGCACTTGGTGATGATGATCAAAAATACTTTTTGGCCCGCTTGATACAAGCTTTTGCTCCAGGTATTCCACAGGTTTATTACGTTGGCTTTTTAGCTGGCAAGAATGATCTTGAATTACTGGAAAGCACTAAAGAAGGCCGCAATATCAACCGTCATTATTATAGTAGTGAAGAAATTGCTAAGGAAGTGAAGCGGCCAGTTGTCAAGGCACTTTTAAATCTCTTTACTTACCGCAATCAGTCAGCAGCTTTTGATTTGGATGGCCGTATTGAAGTGGAAACGCCAAATGAAGCGACCATTGTCATAGAACGTCAAAATAAAGATGGCAGTCATATCGCAAAAGCAGAGATTAATCTCCAAGATATGACATACAGAGTAACAGAAAATGATCAAACAATAAGCTTTGAATAA","4.60","-25.39","55676","MPIINKTMLITYADSLGKNLKELNENIENYFGDAVGGVHLLPFFPSTGDRGFAPIDYHEVDSAFGDWDDVKCLGEKYYLMFDFMINHISRQSKYYKDYQEKHEASAYKDLFLNWDKFWPKNRPTQEDVDLIYKRKDRAPKQEIQFADGSVEHLWNTFGEEQIDLDVTKEVTMDFIRSTIENLAANGCDLIRLDAFAYAVKKLDTNDFFVEPEIWTLLDKVRDIAAVSGAEILPEIHEHYTIQFKIADHDYYVYDFALPMVTLYSLYSSKVDRLAKWLKMSPMKQFTTLDTHDGIGVVDVKDILTDEEITYTSNELYKVGANVNRKYSTAEYNNLDIYQINSTYYSALGDDDQKYFLARLIQAFAPGIPQVYYVGFLAGKNDLELLESTKEGRNINRHYYSSEEIAKEVKRPVVKALLNLFTYRNQSAAFDLDGRIEVETPNEATIVIERQNKDGSHIAKAEINLQDMTYRVTENDQTISFE","835124","From Genbank:[gi:121726]This enzyme is involved in the intracellular catabolism of sucrose,in the production of extracellular glucans that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.","sucrose phosphorylase","Cytoplasm, Extracellular","Matches in gapped BLAST to sucrose phosphorylase: residues 1-481 are 96% similar to a previously published enzyme in S.mutans (gi80000).Residues 1-480 are 83% similar to the enzyme from S.pneumoniae (gi15901721).Residues 1-478 are 66% similar to the enzyme from Leuconostoc mesenteroides (gi2119958).SMu0804 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006047
Domain

Glycosyl hydrolase, family 13, catalytic region
PF00128	$\"[10-396]T$	Alpha-amylase

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[17-429]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
PTHR10357	$\"[35-244]T$ $\"[284-301]T$ $\"[351-478]T$	PTHR10357
PTHR10357:SF11	$\"[35-244]T$ $\"[284-301]T$ $\"[351-478]T$	PTHR10357:SF11
SSF51445	$\"[2-427]T$	SSF51445

","BeTs to 5 clades of COG0366COG name: GlycosidasesFunctional Class: GThe phylogenetic pattern of COG0366 is ----Y-VcEBR----------Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 208-447 are 97% similar to a (SUCROSE PHOSPHORYLASE GLYCOSYLTRANSFERASE) protein domain (PD014068) which is seen in SUCP_STRMU.Residues 448-479 are 96% similar to a (SUCROSE GLYCOSYLTRANSFERASE) protein domain (PD129351) which is seen in SUCP_STRMU.Residues 6-80 are 81% similar to a (SUCROSE PHOSPHORYLASE GLYCOSYLTRANSFERASE) protein domain (PD012864) which is seen in SUCP_STRMU.Residues 81-207 are identical to a (SUCROSE GLUCOSYLTRANSFERASE) protein domain (PD017781) which is seen in SUCP_STRMU.Residues 82-200 are 35% similar to a (HYDROLASE ALPHA-AMYLASE GLYCOSIDASE PRECURSOR SIGNAL) protein domain (PD000173) which is seen in O68017_AGRTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 8 11:26:59 2002","Wed Jan 2 15:04:07 2002","Thu Jun 19 13:22:49 2008","Wed Jan 2 15:04:07 2002","","Wed Jan 2 15:04:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0804 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 15:07:04 2002","","No significant hits to the NCBI PDB database.","SMU.881","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:04:07 2002","24379335","","James,L.C., Hughes,T.A. and Curtiss,R. III.Nucleotide sequence of the gtfA gene from S. mutans GS-5Nucleic Acids Res. 16 (21), 10398 (1988)PubMed: 3194228Russell,R.R., Mukasa,H., Shimamura,A. and Ferretti,J.J.Streptococcus mutans gtfA gene specifies sucrose phosphorylaseInfect. Immun. 56 (10), 2763-2765 (1988)PubMed: 2971020Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267, 4631-4637 (1992)PubMed: 1537846Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890","","Thu Jun 19 13:22:49 2008","","1","","","SMU.881","" "SMu0805","835140","836273","1134","ATGGTTGAACTAAATTTAAATCACATTTATAAAAAATACCCTAACAGCAGTCATTACTCTGTTGAAGATTTTGACTTGGATATCAAGAACAAAGAATTCATCGTTTTTGTTGGTCCTTCAGGCTGCGGAAAATCAACAACCCTTCGGATGGTTGCTGGTTTGGAGGATATTACCAAGGGCGAACTTAAAATTGACGGTGAAGTGGTCAATGATAAGGCCCCCAAAGATCGCGATATTGCTATGGTTTTCCAAAACTATGCGCTTTATCCTCATATGAGCGTTTATGATAATATGGCTTTTGGACTTAAACTACGTCACTATTCCAAAGAAGCTATTGATAAGCGTGTCAAGGAAGCTGCACAAATTCTTGGTCTGACCGAATTTTTAGAACGTAAACCAGCTGATTTATCTGGAGGTCAACGTCAGCGTGTGGCTATGGGTCGGGCAATTGTTCGTGATGCCAAGGTCTTTTTGATGGATGAGCCCCTGTCCAATTTAGATGCCAAGTTGCGGGTATCTATGCGGGCAGAGATTGCGAAAATTCATCGTCGTATCGGTGCAACGACCATTTATGTTACCCATGACCAAACGGAAGCCATGACCTTAGCTGACCGTATTGTTATTATGAGTTCAACAAAAAATGAGGATGGTTCAGGTACAATTGGCCGCGTGGAACAGGTAGGAACGCCTCAGGAACTTTATAACCGGCCTGCTAATAAATTCGTTGCTGGTTTTATCGGCAGTCCGGCCATGAACTTCTTTGATGTTACTATCAAAGATGGGCATCTGGTCAGTAAGGATGGCTTAACGATTGCTGTTACAGAAGGGCAGCTTAAAATGCTTGAGTCTAAAGGTTTTAAGAATAAGAACTTAATTTTTGGTATTCGTCCGGAGGATATTTCCAGCAGTCTTTTAGTTCAGGAAACTTATCCAGATGCTACAGTTGATGCAGAAGTGGTTGTCTCAGAATTGCTTGGCAGTGAAACCATGCTTTATCTTAAACTTGGGCAAACAGAATTTGCAGCACGTGTCGATGCTAGAGATTTCCATGAACCGGGTGAAAAGGTCTCTCTCACCTTTAATGTTGCCAAGGGTCACTTCTTTGACGCAGAAACGGAAGCAGCCATTCGATAA","6.30","-3.85","41952","MVELNLNHIYKKYPNSSHYSVEDFDLDIKNKEFIVFVGPSGCGKSTTLRMVAGLEDITKGELKIDGEVVNDKAPKDRDIAMVFQNYALYPHMSVYDNMAFGLKLRHYSKEAIDKRVKEAAQILGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMDEPLSNLDAKLRVSMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSSTKNEDGSGTIGRVEQVGTPQELYNRPANKFVAGFIGSPAMNFFDVTIKDGHLVSKDGLTIAVTEGQLKMLESKGFKNKNLIFGIRPEDISSSLLVQETYPDATVDAEVVVSELLGSETMLYLKLGQTEFAARVDARDFHEPGEKVSLTFNVAKGHFFDAETEAAIR","836272","For other components see SMu0802 (MSD1); SMu0803 (MSD2) and SMu0801 (SBP1).For other 'msm' genes see SMu0799 (msmR); SMu0801 (msmE); SMu0802 (msmF); SMu0803 (msmG); SMu1079 (msmK); SMu1428 (msmK); SMu0594 (msmK) and SMu0884 (msmK).From Genbank:[gi:547928]This protein is involved in a binding protein-dependent transport system responsible for the uptake of melibose,raffinose and isomaltotriose.It is probably responsible for energy coupling to the transport system.","multiple sugar-binding transport ATP-binding protein MsmK","Cytoplasm, Membrane","Matches in gapped BLAST to multiple sugar-binding transport ATP-binding protein MsmK: residues 1-377 are 100% similar to a previously published protein in S.mutans (gi547928).Residues 1-377 are 84% similar to the protein from S.pyogenes (gi15675768).Residues 1-376 are 73% similar to the protein from Lactococcus lactis (gi12723297).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1925 (0.0).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[136-178]T$	ABC_transporter
PF00005	$\"[31-212]T$	ABC_tran
PS00211	$\"[136-150]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-246]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-213]T$	AAA

InterPro
IPR005116
Domain

TOBE
PF03459	$\"[309-367]T$	TOBE

InterPro
IPR008995
Domain

Molybdate/tungstate binding
SSF50331	$\"[248-376]T$	MOP_like

noIPR
unintegrated

unintegrated
G3DSA:2.40.50.100	$\"[251-315]T$	G3DSA:2.40.50.100
G3DSA:3.40.50.300	$\"[1-249]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-300]T$	PTHR19222
PTHR19222:SF42	$\"[4-300]T$	PTHR19222:SF42
SSF52540	$\"[4-270]T$	SSF52540

","BeTs to 10 clades of COG1130COG name: ABC-type sugar transport system, ATPase componentFunctional Class: GThe phylogenetic pattern of COG1130 is -mtK--VCEBRh--GP-L---Number of proteins in this genome belonging to this COG is 4","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.8e-30. IPB001140A 20-66 IPB001140B 133-171 IPB001140C 188-217","Residues 179-212 are 97% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9CIE2_LACLA.Residues 94-230 are 29% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in Q9CCF9_MYCLE.Residues 25-209 are 27% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 228-261 are identical to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD001887) which is seen in MSMK_STRMU.Residues 180-234 are 43% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472) which is seen in Q9V286_PYRAB.Residues 288-376 are 34% similar to a (ATP-BINDING TRANSPORT) protein domain (PD414565) which is seen in Q9HHQ5_HALN1.Residues 339-376 are identical to a (ATP-BINDING TRANSPORT SUGAR MULTIPLE) protein domain (PD069931) which is seen in MSMK_STRMU.Residues 236-376 are 26% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD407629) which is seen in Q9V286_PYRAB.Residues 267-338 are 55% similar to a (ATP-BINDING TRANSPORT ABC SUGAR) protein domain (PD186376) which is seen in Q9CIE2_LACLA.Residues 180-230 are 52% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9KWT9_BBBBB.Residues 72-109 are identical to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496) which is seen in MSMK_STRMU.Residues 21-71 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in MSMK_STRMU.Residues 136-178 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in MSMK_STRMU.Residues 271-336 are identical to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD020401) which is seen in MSMK_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:45:46 2007","Wed Jan 2 15:16:56 2002","Tue Mar 13 11:31:07 2007","Wed Jan 2 15:16:56 2002","Wed Jan 2 15:16:56 2002","Wed Jan 2 15:16:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0805 is paralogously related (blast p-value < 1e-3) to SMu1428, SMu0884, SMu0594, SMu0971, SMu1920, SMu1003, SMu1950, SMu1079, SMu0731, SMu1210, SMu0517, SMu0418, SMu1762, SMu1380, SMu1288, SMu1068, SMu0235, SMu0218, SMu0849, SMu1949, SMu1246, SMu1231, SMu0916, SMu1757, SMu1751, SMu0786, SMu1001, SMu1518, SMu0390, SMu0216, SMu0825, SMu0234, SMu1023, SMu1316, SMu1037, SMu1517, SMu1064, SMu0335, SMu0907, SMu0596, SMu0950, SMu0836, SMu0824, SMu1036, SMu0976, SMu1065, SMu1649, SMu0986, SMu0837, SMu0258, SMu0476, SMu0475, SMu0164, SMu1710, SMu0374, SMu0024, SMu1724, SMu0752, SMu0944, SMu0987, SMu1410, SMu1093, SMu1811, SMu0823, SMu0666, SMu1050, SMu1545, SMu1306, SMu0224, SMu0729, SMu1959, and SMu1686 all with ATP-binding capabilities.","Wed Mar 20 15:11:13 2002","Tue Mar 13 11:31:07 2007","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 353 2e-098pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 100 3e-022","SMU.882","","Residues 31 to 212 (E-value = 1.9e-58) place SMu0805 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 309 to 367 (E-value = 8.7e-13) place SMu0805 in the TOBE family which is described as TOBE domain (PF03459)","Tue Mar 13 11:31:07 2007","24379336","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 92165821Russell,R.R.B. and Ferretti,J.J. Nucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans J. Gen. Microbiol. 136, 803-810 (1990) PubMed: 2380687 Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B. Biochemical and genetic analysis of Streptococcus mutans alpha-galactosidase J. Gen. Microbiol. 137, 757-764 (1991) PubMed: 1649890 James,L.C., Hughes,T.A. and Curtiss,R. III. Nucleotide sequence of the gtfA gene from S. mutans GS-5 Nucleic Acids Res. 16 (21), 10398 (1988) PubMed: 3194228 Ferretti,J.J., Huang,T.-T. and Russell,R.R.B. Sequence analysis of the glucosyltransferase A (gtfA) gene from Streptococcus mutans Ingbritt Infect. Immun. 56, 1585-1588 (1988) PubMed: 2967248 Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:45:46 2007","","1","","","SMU.882","" "SMu0806","836364","837974","1611","ATGCAAAAACATTGGTGGCACAAGGCAACTGTTTATCAAATTTATCCAAAATCTTTTATGGATACAAATGGTGATGGAATTGGTGATCTCAAAGGCATTACGAGTAAATTGGATTATTTGCAAAAGTTAGGGGTTATGGCTATTTGGCTATCTCCAGTTTATGATAGCCCCATGGATGACAATGGCTATGACATTGCGAACTATGAAGCAATTACGGATATTTTTGGCAATATGGCTGATATGGATAATTTGCTGACGCAGGCAAAAATGCGCGGCATAAAAATCATTATGGATCTAGTGGTTAATCATACCTCAGATGAACACGCTTGGTTTATTGAAGCACGTGAGCATCCAGACAGTTCTGAACGCGATTATTATATTTGGTGTGACCAGCCAAATGATTTGGAATCTATTTTCGGTGGTTCTGCTTGGCAGTATGATGATAAGTCCGATCAATATTATTTGCATTTTTTTAGTAAGAAGCAGCCAGATCTAAACTGGGAAAACGCAAACTTACGTCAGAAGATTTATGATATGATGAATTTCTGGATTGATAAAGGTATTGGCGGCTTTCGGATGGACGTCATTGATATGATTGGGAAAATTCCTGCTCAGCATATTGTCAGTAACGGACCAAAATTGCATGCTTATCTTAAGGAGATGAATGCCGCTAGTTTTGGTCAACATGATCTGCTGACTGTGGGGGAAACTTGGGGAGCAACGCCTGAGATTGCGAAGCAATATTCAAATCCAGTCAATCACGAACTCTCTATGGTTTTTCAATTTGAACATATTGGTCTTCAGCATAAACCAGAAGCTCCTAAATGGGATTATGTGAAGGAACTTAATGTTCCTGCTTTAAAAACAATCTTTAATAAATGGCAGACTGAGTTGGAATTAGGACAGGGGTGGAATTCGTTATTCTGGAATAACCATGACCTGCCTCGTGTTTTATCAATCTGGGGAAATACGGGCAAATATCGTGAGAAGTCTGCTAAAGCACTGGCTATTCTTCTTCACCTTATGCGTGGGACACCTTATATTTATCAAGGTGAAGAGATTGGGATGACCAATTATCCCTTTAAAGATTTAAATGAACTTGATGATATTGAATCCCTTAATTATGCTAAGGAAGCTTTTACAAATGGTAAGTCTATGGAAACTATCATGGACAGTATTCGTATGATTGGCCGTGATAATGCCAGAACACCTATGCAATGGGATGCTTCTCAAAATGCCGGATTTTCAACAGCGGATAAAACATGGCTGCCAGTTAATCCAAACTATAAAGACATCAATGTTCAAGCAGCTCTGAAAAATTCCAATTCTATCTTTTACACCTATCAACAACTCATTCAGCTTCGAAAAGAAAATGATTGGCTAGTAGATGCCGATTTTGAATTGCTCCCTACAGCGGACAAAGTATTTGCCTATTTACGAAAGGTAAGAGAAGAAAGGTATCTTATAGTGGTCAATGTTTCAGATCAGGAAGAAGTTCTAGAGATTGATGTTGACAAACAAGAAACTCTCATTAGCAATACAAATGAAAGCGCTGCTCTTGCCAATCACAAACTCCAGCCTTGGGATGCTTTTTGTATTAAGATAAACTAG","4.90","-20.43","62021","MQKHWWHKATVYQIYPKSFMDTNGDGIGDLKGITSKLDYLQKLGVMAIWLSPVYDSPMDDNGYDIANYEAITDIFGNMADMDNLLTQAKMRGIKIIMDLVVNHTSDEHAWFIEAREHPDSSERDYYIWCDQPNDLESIFGGSAWQYDDKSDQYYLHFFSKKQPDLNWENANLRQKIYDMMNFWIDKGIGGFRMDVIDMIGKIPAQHIVSNGPKLHAYLKEMNAASFGQHDLLTVGETWGATPEIAKQYSNPVNHELSMVFQFEHIGLQHKPEAPKWDYVKELNVPALKTIFNKWQTELELGQGWNSLFWNNHDLPRVLSIWGNTGKYREKSAKALAILLHLMRGTPYIYQGEEIGMTNYPFKDLNELDDIESLNYAKEAFTNGKSMETIMDSIRMIGRDNARTPMQWDASQNAGFSTADKTWLPVNPNYKDINVQAALKNSNSIFYTYQQLIQLRKENDWLVDADFELLPTADKVFAYLRKVREERYLIVVNVSDQEEVLEIDVDKQETLISNTNESAALANHKLQPWDAFCIKIN","837973","For other 'dex' genes see SMu1854 (dexT) and SMu1851 (dexS). From Genbank: [gi:544151]The physiological substrates may be short isomaltosaccharides.","glucan 1,6-alpha-glucosidase","Cytoplasm","Matches in gapped BLAST to glucan 1,6-alpha-glucosidase: residues 1-536 are 99% similar to a previously published enzyme in S.mutans (gi|544151|).Residues 1-535 are 75% similar to the protein in S.pyogenes (gi|15675767|).Residues 1-536 are 75% similar to the enzyme from S.equisimilis (gi|1085813|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1924 (0.0).","

InterPro
IPR006047
Domain

Glycosyl hydrolase, family 13, catalytic region
PF00128	$\"[13-394]T$	Alpha-amylase

InterPro
IPR006589
Domain

Glycosyl hydrolase, family 13, subfamily, catalytic region
SM00642	$\"[13-402]T$	Aamy

InterPro
IPR013780
Domain

Glycosyl hydrolase, family 13, all-beta
G3DSA:2.60.40.1180	$\"[465-536]T$	Glyco_hydro_13_b

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[1-461]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
PTHR10357	$\"[1-271]T$ $\"[305-533]T$	PTHR10357
PTHR10357:SF11	$\"[1-271]T$ $\"[305-533]T$	PTHR10357:SF11
SSF51011	$\"[464-536]T$	SSF51011
SSF51445	$\"[1-461]T$	SSF51445

","BeTs to 6 clades of COG0366COG name: GlycosidasesFunctional Class: GThe phylogenetic pattern of COG0366 is ----Y-VcEBR----------Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 401-482 are 39% similar to a (H SLC3A1 AMINO LARVAL) protein domain (PD154013) which is seen in MAL2_DROME.Residues 305-357 are identical to a (HYDROLASE GLYCOSIDASE ALPHA-GLUCOSIDASE MALTASE PROTEOME) protein domain (PD201428) which is seen in DEXB_STRMU.Residues 302-531 are 28% similar to a (HYDROLASE GLUCOSIDASE MALTASE) protein domain (PD021736) which is seen in AGLA_RHIME.Residues 229-304 are 98% similar to a (HYDROLASE GLYCOSIDASE PROTEOME COMPLETE) protein domain (PD002863) which is seen in DEXB_STRMU.Residues 401-497 are identical to a (HYDROLASE GLYCOSIDASE MALTASE PROTEOME COMPLETE) protein domain (PD002991) which is seen in DEXB_STRMU.Residues 358-400 are 65% similar to a (HYDROLASE PROTEOME COMPLETE GLYCOSIDASE) protein domain (PD414490) which is seen in O84995_STRPN.Residues 305-357 are 73% similar to a (HYDROLASE GLYCOSIDASE ALPHA-AMYLASE) protein domain (PD082291) which is seen in O16G_BACCE.Residues 5-111 are 34% similar to a (ANTIGEN CHAIN HEAVY CD98) protein domain (PD187081) which is seen in 4F2_HUMAN.Residues 33-108 are 36% similar to a (HYDROLASE SYNTHASE PROTEOME COMPLETE) protein domain (PD011989) which is seen in Q55262_SULSO.Residues 61-199 are 24% similar to a (F26D10.9) protein domain (PD237548) which is seen in Q9XVU3_CAEEL.Residues 5-92 are 32% similar to a (C38C6.2) protein domain (PD273859) which is seen in O45298_CAEEL.Residues 358-400 are identical to a (16-ALPHA-GLUCOSIDASE GLUCODEXTRANASE) protein domain (PD410111) which is seen in DEXB_STRMU.Residues 5-57 are identical to a (HYDROLASE GLYCOSIDASE PRECURSOR ALPHA-AMYLASE SIGNAL) protein domain (PD001430) which is seen in DEXB_STRMU.Residues 97-221 are 99% similar to a (HYDROLASE ALPHA-AMYLASE GLYCOSIDASE PRECURSOR SIGNAL) protein domain (PD000173) which is seen in DEXB_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:19:41 2002","Wed Jan 2 15:21:45 2002","Thu Oct 10 18:26:59 2002","Wed Jan 2 15:21:45 2002","","Wed Jan 2 15:21:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0806 is paralogously related (blast p-value < 1e-3) to SMu1851,a predicted dextran glucosidase (probable trehalose-6-phosphate hydrolase), SMu1445; a predicted intracellular a-amylase; and SMu1401, a predicted thermostable pullulanase.","Fri Jan 25 12:51:50 2002","Wed Jan 2 15:21:45 2002","pdb|1UOK| Crystal Structure Of B. Cereus Oligo-1,6-Glucosidase 572 4e-164pdb|1BVZ|A Chain A, Alpha-Amylase Ii (Tvaii) From Thermoactinom... 127 3e-030pdb|1SMA|A Chain A, Crystal Structure Of A Maltogenic Amylase >... 92 1e-019","SMU.883","","Residues 13 to 394 (E-value = 3e-144) place SMu0806 in the Alpha-amylase family which is described as Alpha amylase, catalytic domain (PF00128)","Wed Jan 2 15:21:45 2002","24379337","","Russell,R.R. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136 (Pt 5), 803-810 (1990)PubMed: 90338976Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. and Ferretti,J.J. A binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism J. Biol. Chem. 267 (7), 4631-4637 (1992) PubMed: 1537846 Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B. Biochemical and genetic analysis of Streptococcus mutans alpha-galactosidase J. Gen. Microbiol. 137, 757-764 (1991) PubMed: 1649890 Ferretti,J.J., Huang,T.-T. and Russell,R.R.B. Sequence analysis of the glucosyltransferase A (gtfA) gene from Streptococcus mutans Ingbritt Infect. Immun. 56, 1585-1588 (1988) PubMed: 2967248 ","","Wed Mar 27 09:43:12 2002","","1","","","SMU.883","" "SMu0807","839132","838128","1005","GTGATAATGGCTACATTAAAAGACATTGCAAAATTAGCAAAAGTTTCTCAGGCAACGGTTTCCAGAGTATTGAACAAAGATGAAACCTTATCTGTCAGTCAAAAGACCAAGCATCGTATTTTAATGGTTGCTGATGAGCTTGGTTATCAGAAGCATTTAAAAACCACTAATTCTCCTCAGGTCAGACAAAAAATTGCTATCGTGCAATGGTACAGTCAGCAGGAAGAACTCAACGATCTTTATTACTATTCTATTCGTATCGGTATTGAAAAGCGTGCTCAGGAATTGGACTATGATATTGTCCGTTATTTTGATAACGATATCAGTAAAGTGTCTGCAGATATCGTCGGTCTCATTGCCATCGGTAAATTCAGTACTTATCAAATTGCAGAGCTGGAAAAATTATCCGATAAACTAATTTTTGTTGACAGTGACACTCTCAACGCTGGGTATCCTTGCGTAATGACTGACTTTGACAATGCTGTTGTTAAAGTTTTAGATTATTTTTTAGACCATGGCTTAACCAAAATTGGTATGATTGCTGGCGAAGAAAAAACGACAGATGGCAGAGAACTGCTCATTGATCAACGGTTTCGTACCTTTCGAAATTATGCCTATGAACAAGACATCTACAATCCAAACTATATCTTCATTGGGGACTTTTCAGCACAGACTGGTTATCATTTGATGAAAAAGGCCATCAAAGAACTCAAGGAAAACTTACCACAAGCATTTTTTATTGCTAATGATAGCTTAGCCATTGGAGCGCTTCGTGCTTTGCAAGAAGCAAACATTCCTGTCCCCAATCGTGTCAGTTTGATTTCTTTTAACGATACAGCCTTGACTAAACAGGTCTTCCCAGCACTCTCCAGCATTACTGTCTTTACCAAAGAAATGGGCCGTACTGCTGTTGATATCCTCAACAGACAAATCCTTAACCCTGATATTATTCCAAGCATGACCAGATTGACCACTCAGCTGACATTAAGAGAAAGCAGCATTTAG","6.50","-1.07","37902","MIMATLKDIAKLAKVSQATVSRVLNKDETLSVSQKTKHRILMVADELGYQKHLKTTNSPQVRQKIAIVQWYSQQEELNDLYYYSIRIGIEKRAQELDYDIVRYFDNDISKVSADIVGLIAIGKFSTYQIAELEKLSDKLIFVDSDTLNAGYPCVMTDFDNAVVKVLDYFLDHGLTKIGMIAGEEKTTDGRELLIDQRFRTFRNYAYEQDIYNPNYIFIGDFSAQTGYHLMKKAIKELKENLPQAFFIANDSLAIGALRALQEANIPVPNRVSLISFNDTALTKQVFPALSSITVFTKEMGRTAVDILNRQILNPDIIPSMTRLTTQLTLRESSI","838133","For other 'gal' genes see SMu0808 (galK); SMu0809 (galT); SMu0810 (galE); SMu1874 (galE) and SMu0289 (galU).From Genbank:[gi:7442856]This protein is a transcriptional regulator which binds as a dimerto the operator sequence and requires a specific carbohydrateeffector molecule for a proper regulatory function .","galactose repressor","Cytoplasm","Matches in gapped BLAST to galactose repressor: residues 3-334 are98% similar to a previously published enzyme in S.mutans (gi|7442856|).Residues 3-334 are 59% similar to the protein from S.pneumoniae (gi|15901682|).Residues 3-333 are 56% similar to the protein from S.thermophilus (gi|8928119|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0707 (6e-15).","

InterPro
IPR000843
Domain

Bacterial regulatory protein, LacI
PR00036	$\"[5-15]T$ $\"[15-25]T$	HTHLACI
PF00356	$\"[4-29]T$	LacI
SM00354	$\"[3-74]T$	HTH_LACI
PS50932	$\"[4-55]T$	HTH_LACI_2
PS00356	$\"[6-24]T$	HTH_LACI_1

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[4-62]T$	no description
G3DSA:3.40.50.2300	$\"[157-305]T$	no description

","BeTs to 4 clades of COG1609COG name: Transcriptional regulators of the LacI familyFunctional Class: KThe phylogenetic pattern of COG1609 is ------V-EBrH---------Number of proteins in this genome belonging to this COG is 5","***** IPB000843 (Bacterial regulatory protein, LacI family) with a combined E-value of 2.8e-17. IPB000843A 5-25 IPB000843B 32-70","Residues 144-278 are 53% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000591) which is seen in GALR_STRTR.Residues 69-135 are 53% similar to a (GALACTOSE REPRESSOR TRANSCRIPTION) protein domain (PD413070) which is seen in GALR_STRTR.Residues 4-53 are 48% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000947) which is seen in Q9RKF2_STRCO.Residues 5-49 are 75% similar to a (DNA-BINDING TRANSCRIPTION REGULATION) protein domain (PD407822) which is seen in GALR_STRTR.Residues 65-134 are 36% similar to a (PROTEOME DNA-BINDING REGULATION COMPLETE) protein domain (PD413629) which is seen in Q9KBB0_BACHD.Residues 65-169 are 25% similar to a (REPRESSOR REGULATION TRANSCRIPTION) protein domain (PD395348) which is seen in EBGR_ECOLI.Residues 279-333 are 63% similar to a (GALACTOSE REPRESSOR TRANSCRIPTION) protein domain (PD383487) which is seen in GALR_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:21:55 2002","Wed Jan 2 15:27:09 2002","Sat Oct 12 12:20:12 2002","Wed Jan 2 15:27:09 2002","Wed Jan 2 15:27:09 2002","Wed Jan 2 15:27:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0807 is paralogously related (blast p-value < 1e-3) to SMu1446, SMu1679, SMu1424, and SMu0094; all predicted lacI family and related sugar operon repressors.","Wed Mar 20 15:15:03 2002","Wed Jan 2 15:27:09 2002","pdb|1VPW|A Chain A, Structure Of The Purr Mutant, L54m, Bound T... 83 6e-017pdb|2PUE|A Chain A, Crystal Structure Of The Laci Family Member... 83 6e-017pdb|2PUA|A Chain A, Crystal Structure Of The Laci Family Member... 83 6e-017","SMU.885c","","Residues 4 to 29 (E-value = 1.9e-11) place SMu0807 in the LacI family which is described as Bacterial regulatory proteins, lacI family (PF00356)Residues 62 to 331 (E-value = 8.4e-05) place SMu0807 in the Peripla_BP_1 family which is described as Periplasmic binding proteins and sugar binding domain of the LacI family (PF00532)","Wed Jan 2 15:27:09 2002","","","Ajdic,D., Sutcliffe,I.C., Russell,R.R. and Ferretti,J.J.Organization and nucleotide sequence of the Streptococcus mutansgalactose operonGene 180 (1-2), 137-144 (1996)PubMed: 8973358","Bettenbrock,K. and Alpert,C.A.The gal genes for the Leloir pathway of Lactobacillus casei 64HAppl. Environ. Microbiol. 64 (6), 2013-2019 (1998)PubMed: 9603808","Fri Jan 25 12:57:03 2002","Fri Jan 25 13:00:46 2002","1","","","SMU.885c","" "SMu0808","839269","840441","1173","ATGAAAAAACAAGAATTAAACCAAGCCTTTACTCACGTTTTTGGAAGAGAAGCAGACGCTACTTTTTTCTCACCGGGACGTATCAATCTTATTGGAGAGCATACCGATTATAATGGCGGTCGTGTCTTTCCCGCAGCAATCACCTTGGGAACATACGGTGCAGCTCGTAAACGTGATGATAAATTACTCCGCTTTTACTCCGCTAACTTTGAAGAACTTGGTATTATTGAAATCAGTCTTGATCATCTTATATTTAATAAGAAGGATAGTTGGACGAATTATCCTAAAGGCGTCATCAAATACTTGCAAGAAGCAGGGCACTCGATTGACACTGGTATGGATGTCTATGTTTTTGGAAATATTCCAAATGGTTCTGGGCTATCTTCATCTTCATCTCTTGAATTGTTGATTGGGATTATGGCTGAAGAGTTGTTTGATCTTAAACTTGATCGTCTTGATTTAGTAAAAATTGGGAAAAGAACTGAAAATGACTTTATCGGTGTTAATTCAGGAATCATGGATCAATTTGCTATTGGTATGGGAGCTGAAAAGAAGGCTATTTATCTTGATACGAAGACTTTGGAATATGATCTTGTACCGCTTGACCTTGGTGACAATGTTATTGTTATTATGAATACCAACAAACGCCGTGAGTTGGCTGACTCGAAATATAATGAGCGCCGTACGGAATGTGAAAAAGCAGTCGAAGAATTGAATGTTCTTCTTGACATCAAGTCTCTTGGTGAATTGGATGAAGAAACTTTTGACGAATATGCTTATCTCATCAAGGATGCTAAGCGTATCAAACGCGCTCGCCATGCAGTTTCTGAAAATCAAAGAACTCTGAAAGCTAAGAAAGCCCTTGCAGCTGGTGATTTGGAGAAATTTGGACGGCTGGTCAATGCCTCGCATGTTTCTCTGGAACATGACTATGAAGTAACAGGGATTGAACTTGACACGCTGGCTCATACCGCTTGGGAACAAGAAGGTGTTCTGGGCGCTCGTATGACAGGAGCTGGTTTTGGCGGCTGCGGCATTGCTATTGTTGCCAAAGATAAGGTTGCAGCCTTAAAAGAAAATGTCGGTCGCATTTACACTGAAACAGTAGGTTACGCGCCAGCCTTTTATATCGCAGAAATCGCAGGCGGCAGTCGTGTTCTCTCAAGGAAATAA","5.60","-7.13","43223","MKKQELNQAFTHVFGREADATFFSPGRINLIGEHTDYNGGRVFPAAITLGTYGAARKRDDKLLRFYSANFEELGIIEISLDHLIFNKKDSWTNYPKGVIKYLQEAGHSIDTGMDVYVFGNIPNGSGLSSSSSLELLIGIMAEELFDLKLDRLDLVKIGKRTENDFIGVNSGIMDQFAIGMGAEKKAIYLDTKTLEYDLVPLDLGDNVIVIMNTNKRRELADSKYNERRTECEKAVEELNVLLDIKSLGELDEETFDEYAYLIKDAKRIKRARHAVSENQRTLKAKKALAAGDLEKFGRLVNASHVSLEHDYEVTGIELDTLAHTAWEQEGVLGARMTGAGFGGCGIAIVAKDKVAALKENVGRIYTETVGYAPAFYIAEIAGGSRVLSRK","840440","For other 'gal' genes see SMu0807 (galR); SMu0809 (galT); SMu0810 (galE); SMu1874 (galE) and SMu0289 (galU).","galactokinase","Cytoplasm","Matches in gapped BLAST to galactokinase: residues 1-390 are93% similar to the previously published enzyme in S.mutans (gi|2494673|).Residues 4-387 are 73% similar to the enzyme from S.pneumoniae (gi|15901681|).Residues 1-387 are 72% similar to the enzyme from S.thermophilus (gi|8928118|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1326 (5e-05).","

InterPro
IPR000705
Family

Galactokinase
PR00473	$\"[26-44]T$ $\"[91-102]T$ $\"[112-130]T$ $\"[269-283]T$	GALCTOKINASE
PIRSF000530	$\"[2-389]T$	Galactokinase
TIGR00131	$\"[3-387]T$	gal_kin
PS00106	$\"[26-37]T$	GALACTOKINASE

InterPro
IPR006203
Domain

GHMP kinase, ATP-binding region
PS00627	$\"[121-132]T$	GHMP_KINASES_ATP

InterPro
IPR006204
Domain

GHMP kinase
PF00288	$\"[114-182]T$	GHMP_kinases_N

InterPro
IPR006206
Family

Mevalonate and galactokinase
PR00959	$\"[24-48]T$ $\"[119-141]T$ $\"[162-181]T$ $\"[333-350]T$	MEVGALKINASE

InterPro
IPR013750
Domain

GHMP kinase, C-terminal
PF08544	$\"[284-367]T$	GHMP_kinases_C

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[1-213]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.890	$\"[248-378]T$	G3DSA:3.30.70.890
PTHR10457	$\"[78-367]T$	PTHR10457
PTHR10457:SF6	$\"[78-367]T$	PTHR10457:SF6
SSF54211	$\"[1-204]T$	SSF54211
SSF55060	$\"[205-387]T$	SSF55060

","BeTs to 7 clades of COG0153COG name: GalactokinaseFunctional Class: GThe phylogenetic pattern of COG0153 is ---kY-vcebrh-----l---Number of proteins in this genome belonging to this COG is 1","***** IPB000705 (Galactokinase) with a combined E-value of 1.9e-113. IPB000705A 24-47 IPB000705B 89-99 IPB000705C 112-133 IPB000705D 162-190 IPB000705E 208-238 IPB000705F 269-281 IPB000705G 296-322 IPB000705H 333-344***** PR00959 (Mevalonate kinase signature) with a combined E-value of 2.5e-52. PR00959A 24-48 PR00959B 119-141 PR00959C 162-181 PR00959D 333-350***** IPB001745 (GHMP kinases putative ATP-binding domain) with a combined E-value of 2.1e-26. IPB001745A 25-34 IPB001745B 121-132 IPB001745C 162-171 IPB001745D 333-344***** PR00960 (LmbP protein signature) with a combined E-value of 9.1e-06. PR00960A 24-39 PR00960B 120-141 PR00960C 162-181 PR00960E 327-346","Residues 273-361 are 88% similar to a (KINASE GALACTOSE GALACTOKINASE) protein domain (PD002375) which is seen in GAL1_STRMU.Residues 24-109 are 58% similar to a (KINASE GALACTOSE GALACTOKINASE) protein domain (PD003096) which is seen in GAL1_BACSU.Residues 1-236 are 21% similar to a (GALACTOSE KINASE ATP-BINDING TRANSFERASE) protein domain (PD306534) which is seen in GAL1_TREPA.Residues 6-251 are 22% similar to a (GALACTOKINASE-LIKE) protein domain (PD302657) which is seen in Q9SG76_ARATH.Residues 24-182 are 91% similar to a (KINASE GALACTOSE GALACTOKINASE) protein domain (PD017586) which is seen in GAL1_STRMU.Residues 186-222 are identical to a (KINASE GALACTOSE GALACTOKINASE) protein domain (PD365853) which is seen in GAL1_STRMU.Residues 223-258 are 97% similar to a (GALACTOSE KINASE ATP-BINDING TRANSFERASE) protein domain (PD347757) which is seen in GAL1_STRMU.Residues 223-280 are 44% similar to a (GALACTOSE KINASE ATP-BINDING TRANSFERASE) protein domain (PD386865) which is seen in GAL1_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:21:03 2002","Wed Jan 2 15:29:16 2002","Sat Oct 12 12:21:03 2002","Wed Jan 2 15:29:16 2002","Fri Dec 21 17:01:29 2001","Fri Dec 21 17:01:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu0808 is paralogously related (blast p-value < 1e-3) to SMu0163, a predicted mevalonate kinase.","Fri Jan 25 13:01:55 2002","","No significant hits to the NCBI PDB database.","SMU.886","","Residues 112 to 351 (E-value = 1.5e-56) place SMu0808 in the GHMP_kinases family which is described as GHMP kinases putative ATP-binding protein (PF00288)","Fri Dec 21 17:01:29 2001","24379339","","Ajdic,D., Sutcliffe,I.C., Russell,R.R. and Ferretti,J.J.Organization and nucleotide sequence of the Streptococcus mutansgalactose operonGene 180 (1-2), 137-144 (1996)PubMed: 8973358","Vaughan,E.E., Pridmore,R.D. and Mollet,B.Transcriptional regulation and evolution of lactose genes in thegalactose-lactose operon of Lactococcus lactis NCDO2054J. Bacteriol. 180 (18), 4893-4902 (1998)PubMed: 9733693","Fri Jan 25 13:01:55 2002","Wed Jan 2 15:31:49 2002","1","","","SMU.886","" "SMu0809","840446","841921","1476","ATGACAGCATTACTAGATACTTTTGTTAGTAAAATTATTGAAAATAGTGACTATGCTGAGTTGGATGCTACCTACCTTAGCAATCGTATTCTTGCTTTGGTCGGTGAAGACAATGCTCAGCAGGATACAAACCAAAGCAACCTCATTGCTCTTAAGGATGAATTGGTTGATTTGGCTGTTGTGAACGGTAAAGTTGGCGACTTAGCTGAAGAGAAAGATTGCTTGGGAGCGGAGTTAATGAACTTCATCACGCCAATTCCAAGTCAGGTCAATAAAGCTTTCTGGGATACTAATGCAAAATCTCCTCAGAAAGCTATCAAAGATTTCTATGAACTCAGTAAGCGTAACAACTATATTAAAGTGACCGCTATTGCTAAAAATATTGCTTTCACAACGTCATCAGTTTATGGGGATATTGACATTACTATCAATTTGTCAAAACCTGAAAAGGATCCTAAAGCTATTGCAGCAGCTAAGTTAGCTAAGACTTCCAATTATCCCAAGTGCCAACTTTGCATGGAAAATGAAGGCTATCAGGGTAGGATTAATTATCCTGCTCGTGCCAACCATCGCATTATCCGTATGAATTTGGGTGATGAGAAATGGGGCTTCCAGTATTCTCCTTACGCTTATTTCAACGAGCACTGCATTTTTCTCAACACTGAGCATGTACCTATGGTGATTAGCCAGAACACTTTTAGACAGCTCCTTGACATTGTAGACATCTTCCCGGGTTATTTTGCGGGTTCTAACTCAGATTTGCCTATTGTCGGTGGCTCTATCTTAAGTCACAATCATTATCAAGGCGGCCGTCACATTTTTCCTATGGAAATAGCAGAGTTGGATAGCGTGTTTCGTTTCAAAGACTTTCCAGATGTGACAGCAGGTATTGTCAAGTGGCCTATGTCAGTTATCAGACTGCGTGGAGCAAACAAGTATAGCTTGGTGGAATTGGCTGAAATCATTCGTCTGGCTTGGCGTAACTATTCTGATGATACGATGAACATTCTTGCATTTACAGGTGATACACCGCATCACACTGTGACACCGATTGCTCGAAAACGCGATGGACAATTTGAGCTGGATATTGTTTTACGTGACAATCATACGACAGCAGAGTATCCTGACGGAGTTTATCATCCTCATATTGATGTGCAGCATATTAAGAAAGAAAATATCGGGCTGATTGAGGTTATGGGCTTAGCCATTTTACCGCCAAGACTGAAAAAAGAGCTGGCAGAAGTTGAAAAATACGTGTTAAACCAGTATAATGAAATGGCCGATTACCACAAAGACTGGGCTGATGCCATTAAGGCCAGTCATCCAGAAACGAGTTCAGAAACCGTTTCAGAAATTGTCAAACAAGCTGTTGGGAGAACCTTTGTCCGTGTCTTGGAAGACGCAGGTGTCTACAAACGTAATAGACAGGGGCAAGCAGCTTTCATGCGGTTTGTAGAGAGTATTGGAGTGAAGTAA","6.20","-6.78","55435","MTALLDTFVSKIIENSDYAELDATYLSNRILALVGEDNAQQDTNQSNLIALKDELVDLAVVNGKVGDLAEEKDCLGAELMNFITPIPSQVNKAFWDTNAKSPQKAIKDFYELSKRNNYIKVTAIAKNIAFTTSSVYGDIDITINLSKPEKDPKAIAAAKLAKTSNYPKCQLCMENEGYQGRINYPARANHRIIRMNLGDEKWGFQYSPYAYFNEHCIFLNTEHVPMVISQNTFRQLLDIVDIFPGYFAGSNSDLPIVGGSILSHNHYQGGRHIFPMEIAELDSVFRFKDFPDVTAGIVKWPMSVIRLRGANKYSLVELAEIIRLAWRNYSDDTMNILAFTGDTPHHTVTPIARKRDGQFELDIVLRDNHTTAEYPDGVYHPHIDVQHIKKENIGLIEVMGLAILPPRLKKELAEVEKYVLNQYNEMADYHKDWADAIKASHPETSSETVSEIVKQAVGRTFVRVLEDAGVYKRNRQGQAAFMRFVESIGVK","841920","For other 'gal' genes see SMu0807 (galR); SMu0808 (galK); SMu0810 (galE); SMu1874 (galE) and SMu0289 (galU).","galactose-1-phosphate uridylyltransferase","Cytoplasm","Matches in gapped BLAST to galactose-1-phosphate uridylyltransferase: residues 1-491 are 98% similar to a previously published enzyme in S.mutans (gi|2494675|).Residues 1-490 are 65% similar to the enzyme from S.pneumoniae (gi|15903690|).Residues 4-490 are 61% similar to the enzyme from S.thermophilus (gi|8928117|). SMu0809 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000766
Family

Galactose-1-phosphate uridyl transferase, class II
PIRSF006005	$\"[2-491]T$	GalT_BS
TIGR01239	$\"[4-488]T$	galT_2
PS01163	$\"[253-270]T$	GAL_P_UDP_TRANSF_II

InterPro
IPR005849
Domain

Galactose-1-phosphate uridyl transferase, N-terminal
PF01087	$\"[16-225]T$	GalP_UDP_transf

InterPro
IPR005850
Domain

Galactose-1-phosphate uridyl transferase, C-terminal
PF02744	$\"[227-435]T$	GalP_UDP_tr_C

","No hits to the COGs database.","***** IPB000766 (Galactose-1-phosphate uridyl transferase, class II) with a combined E-value of 1.2e-199. IPB000766A 67-94 IPB000766B 136-188 IPB000766C 189-225 IPB000766D 227-270 IPB000766E 271-298 IPB000766F 331-366","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:23:27 2002","Wed Jan 2 15:33:58 2002","Sat Oct 12 12:23:27 2002","Wed Jan 2 15:33:58 2002","Wed Jan 2 15:33:58 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0809 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 15:34:43 2002","","No significant hits to the NCBI PDB database.","SMU.887","","Residues 16 to 225 (E-value = 3.4e-117) place SMu0809 in the GalP_UDP_transf family which is described as Galactose-1-phosphate uridyl transferase, N-terminal domain (PF01087)Residues 227 to 435 (E-value = 2.3e-125) place SMu0809 in the GalP_UDP_tr_C family which is described as Galactose-1-phosphate uridyl transferase, C-terminal domain (PF02744)","Wed Jan 2 15:33:58 2002","24379340","","Ajdic,D., Sutcliffe,I.C., Russell,R.R. and Ferretti,J.J.Organization and nucleotide sequence of the Streptococcus mutansgalactose operonGene 180 (1-2), 137-144 (1996)PubMed: 8973358","","Mon Mar 25 13:02:35 2002","","1","","","SMU.887","" "SMu0810","842007","843071","1065","ATGCAGGTGTCTGCGTCAAGTTTCCTTTTTTGCTCTGTCGTTTACGGGCTTGGTATCTTAATTATGGCTATTTTAGTTTTAGGTGGAGCTGGTTATATTGGTTCACACATGGTTGACCGTCTTATTGAAAAAGGTGAGGAAGAGGTTGTTGTCGTTGATAGTTTGGTGACGGGTCACCGTGCAGCAGTACACCCAGCTGCTAAGTTTTATCAAGGTGATTTAGCAGATCGAGAGTTTATGAGTATGGTTTTTAGAGAAAATCCTGATGTGGATGCCGTTATTCACTTTGCAGCTTATTCTTTGGTTGCAGAGTCCATGAAAAAGCCCCTCAAGTATTTTGACAACAACACCGCAGGCATGATTAAACTCTTGGAAGTCATGAGTGAATTTGGTGTCAAATATATCGTCTTTTCATCAACAGCAGCAACCTATGGTATTCCTGATGAAATTCCAATCAAGGAAACAACACCGCAGCGTCCGATTAATCCATACGGTGAGAGTAAACTCATGATGGAAACCATTATGAAATGGTCTGACCGGGCCTACGGTATCAAGTTTGTGCCACTTCGCTATTTCAATGTGGCTGGTGCAAAACCAGATGGCTCAATCGGTGAAGATCACAGTCCTGAAACACATCTACTGCCAATCATTTTGCAGGTTGCTCAAGGCGTGCGTGAGAAAATCATGATTTTTGGTGATGATTATAACACGCCAGATGGTACCAATGTGCGCGATTATGTACACCCTTTTGATTTGGCGGATGCTCACCTGCTTGCTCTTAACTATCTGCGCCAAGGCAATCCATCAACGGCCTTTAACTTGGGATCATCAACAGGATTTTCAAATCTTCAAATTTTAGAAGCCGCTCGTAAAGTTACGGGACAGAAAATCCCTGCAGAAAAAGCAGCTCGCCGTTCGGGAGATCCAGATACTTTGATTGCATCTTCAGAAAAAGCACGTGAGGTGCTTGGCTGGAAACCGCAATTTGATGACATTGAAAAAATCATTGCCTCCGCTTGGGCATGGCATTCCAGCTATCCAAAGGGTTATGATGACAGAGACTGA","5.50","-7.86","39125","MQVSASSFLFCSVVYGLGILIMAILVLGGAGYIGSHMVDRLIEKGEEEVVVVDSLVTGHRAAVHPAAKFYQGDLADREFMSMVFRENPDVDAVIHFAAYSLVAESMKKPLKYFDNNTAGMIKLLEVMSEFGVKYIVFSSTAATYGIPDEIPIKETTPQRPINPYGESKLMMETIMKWSDRAYGIKFVPLRYFNVAGAKPDGSIGEDHSPETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADAHLLALNYLRQGNPSTAFNLGSSTGFSNLQILEAARKVTGQKIPAEKAARRSGDPDTLIASSEKAREVLGWKPQFDDIEKIIASAWAWHSSYPKGYDDRD","843070","For other 'gal' genes see SMu0807 (galR); SMu0808 (galK); SMu0809 (galT); SMu1874 (galE) and SMu0289 (galU).From Genbank: [gi:7437233]This enzyme is involved in the Leloir pathway and cell wall synthesis.","UDP-glucose 4-epimerase","Cytoplasm","Matches in gapped BLAST to UDP-glucose 4-epimerase:residues 22-354 are 98% similar to the previously published enzyme in S.mutans (gi|2494665|). Residues 22-353 are 86% similar to the protein in S.thermophilus (gi|120925|).Residues 22-354 are 68% similar to the protein in Lactobacillus casei (gi|6225406|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1923 (1e-163).","

InterPro
IPR001509
Family

NAD-dependent epimerase/dehydratase
PF01370	$\"[24-275]T$	Epimerase

InterPro
IPR005886
Family

UDP-glucose 4-epimerase
PTHR10366:SF39	$\"[26-354]T$	UDP-GLUCOSE 4-EPIMERASE
TIGR01179	$\"[23-350]T$	galE: UDP-glucose 4-epimerase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[24-249]T$	no description
PTHR10366	$\"[26-354]T$	NAD DEPENDENT EPIMERASE/DEHYDRATASE
signalp	$\"[1-30]?$	signal-peptide
tmhmm	$\"[10-32]?$	transmembrane_regions

InterPro
IPR001466
Family

Beta-lactamase
PF00144	$\"[36-340]T$	Beta-lactamase

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[36-341]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[36-321]T$	G3DSA:3.40.710.10
PTHR22935	$\"[36-273]T$	PTHR22935
PTHR22935:SF15	$\"[36-273]T$	PTHR22935:SF15

","BeTs to 6 clades of COG1680COG name: Beta-lactamase class C and other penicillin binding proteinsFunctional Class: MThe phylogenetic pattern of COG1680 is ---k---CEBR---------xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 81-187 are 34% similar to a (PROTEOME YVDA COMPLETE) protein domain (PD401603) which is seen in Q9CE05_LACLA.Residues 56-133 are 38% similar to a (AMPH PENICILLIN-BINDING) protein domain (PD104423) which is seen in AMPH_ECOLI.Residues 48-133 are 36% similar to a (BETA-LACTAMASE PRECURSOR COMPLETE) protein domain (PD000806) which is seen in O24823_SERMA.Residues 36-148 are 30% similar to a (BETA-LACTAMASE CEPHALOSPORINASE HYDROLASE) protein domain (PD352454) which is seen in AMPC_PROST.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 10:52:27 2006","Sat Oct 12 12:25:07 2002","Thu Sep 28 10:52:27 2006","Wed Jan 2 15:51:46 2002","","Wed Jan 2 15:51:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0811 is paralogously related (blast p-value < 1e-3) to SMu0361, a predicted esterase.","Fri Jan 25 13:18:24 2002","","No significant hits to the NCBI PDB database.","SMU.889","","Residues 36 to 340 (E-value = 8.6e-12) place SMu0811 in the Beta-lactamase family which is described as Beta-lactamase (PF00144)","Wed Jan 2 15:51:46 2002","24379342","","","","","","1","","","SMU.889","" "SMu0812","844622","845164","543","ATGAAAGATTTGTGCTTTAAGAAGGTACATAGAGATAAGATGAAAAATTATGCAGAGTTTTATGAGAAACTGACAAAGCCAATCAAAACAAGAAGTAAATGGCTTTATTTTGTAAAAGCAGTTAATTCTGTAATAACCAGAATAATGCCCTTTATTTATCTGATACTTTTACTTTACCTTTTTTGGACTCGAAAGAATGGGATGGCTTTAATACCTTTTGTTTTCATTCCGGGAACATCCTTTATATTACTGTCATTATTTAGAAAGATGTTAAATCAGCCAAGACCTTATGAAAGGTGGACGATCAGTCCATTAATCATTAAGGACGCTAAGGGACAGTCCATGCCCAGCCGTCATGTCTTTTCGGCAGTGGTGATTAGTGTTTGTGTTCTACGTGTGACCACTTGGGCTGGAATCTTTTTATTAATCTTATCCGCCATACTAGCATTTTGCCGTGTTCTAGGCGGTGTTCATTACCCCAAAGATGTTGTAGTGGGCTACATCACTGGTCTTATGGCAGGAAGCCTGCTCTTTTTGGTTTAA","11.00","18.56","20757","MKDLCFKKVHRDKMKNYAEFYEKLTKPIKTRSKWLYFVKAVNSVITRIMPFIYLILLLYLFWTRKNGMALIPFVFIPGTSFILLSLFRKMLNQPRPYERWTISPLIIKDAKGQSMPSRHVFSAVVISVCVLRVTTWAGIFLLILSAILAFCRVLGGVHYPKDVVVGYITGLMAGSLLFLV","845163","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical protein: residues 14-179 are 40% similar to the protein in S.pyogenes (gi|15675663|) and are 42% similar to the protein from S.pneumoniae (gi|15903774|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1718 (9e-35).","

InterPro
IPR000326
Family

Phosphoesterase, PA-phosphatase related
PF01569	$\"[69-170]T$	PAP2
SM00014	$\"[70-178]T$	acidPPc

InterPro
IPR008934
Family

Acid phosphatase/vanadium-dependent haloperoxidase
SSF48317	$\"[17-180]T$	AcPase_VanPerase

noIPR
unintegrated

unintegrated
G3DSA:1.20.144.10	$\"[82-173]T$	G3DSA:1.20.144.10
PTHR14969	$\"[58-180]T$	PTHR14969
PTHR14969:SF3	$\"[58-180]T$	PTHR14969:SF3

","BeTs to 7 clades of COG0671COG name: Predicted phosphatasesFunctional Class: RThe phylogenetic pattern of COG0671 is -mtkYq-cEBrhUJ---l--xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:22:23 2002","Wed Jan 2 15:55:43 2002","Fri Jan 25 13:22:23 2002","Wed Jan 2 15:55:43 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0812 is paralogously related (blast p-value < 1e-3) to SMu1550, a predicted conserved hypothetical protein / possible phosphatase.","Fri Jan 25 13:22:23 2002","","No significant hits to the NCBI PDB database.","SMU.890","","Residues 55 to 180 (E-value = 3.2e-05) place SMu0812 in the PAP2 family which is described as PAP2 superfamily (PF01569)","Wed Jan 2 15:55:43 2002","24379343","","","","","","1","","","SMU.890","972" "SMu0813","845296","846900","1605","ATGTCGTTCAATAAGGAAAGTCAGCAAAGACAAGAATTGCATCAAAAAATATGGGCTATTGCTGACAATGTACGTGGTGCTGTAGATGGTTGGGATTTTAAGCAATATATCTTAGGGATTCTTTTTTATCGTTTTATTTCTGAAAATATGTCTGATTATTTTGATCGTGCTGAACATGAGGCCGGTGATCCAGACTTTCGTTATGCTGATCTCAGTGATGAAGAAGCTGAAGAAGATTTTAAACCCGATACAGTAGAAGAAAAAGGCTTTTTTATTTTGCCTTCACAACTCTTTGAAAATATAGTCAAAACAGCCTCAACAAATGAAAATTTAAACACGGACTTAGCAAAGATTTTCAAGAAAATTGAAGAATCCGCAATTGGTAAAGATTCAGAACATGCGATTAAGGGACTCTTTGATGATGTGGATACAACCTCAAATCGTTTGGGAGGTTCTGTTAAAGAAAAGAACAAACGATTATCAGATATTTTGACAGGAATAGCTGGGCTTGATTTTGGCACTTTTGAAGAAAATGATATTGATGCATTTGGTGATGCCTATGAGTATCTGATTTCTAACTATGCCTCTAATGCAGGAAAAAGTGGCGGAGAGTTTTTTACACCGCAAACTGTTTCGAAACTTCTTGCTCAACTTGTTATGGTTGGAAAAGAGCATATTAATAAAGTATATGATCCAACTTGTGGTTCGGGTTCACTATTACTTCAAATGAAGAAACAATTTGAAACCCATATTTTGGAAGAAGGTTTTTTTGGTCAAGAGATCAATATGACTAATTATAACTTAGCACGAATGAATATGTTTCTTCATAATATCAACTATAATAATTTTGATATTCGCCGTGGCGATACCTTGTTGAACCCTCAGCATCTATACGAACGACCTTTTGATGCCATTGTTTCTAATCCTCCTTATTCTATCAAGTGGATTGGGGATGCTGATCCAACCTTAATTAATGATGAGCGCTTTGCACCAGCTGGTAAATTAGCTCCTAAATCAAAAGCTGATTTTGCCTTTATTATGCACAGTCTTAGCCATTTATCCAATAAAGGTCGTGCAGCAATTGTTTGCTTTCCTGGAATTTTTTATCGCGGGGGTGCTGAGAAGACAATCCGTCAATACTTGATTGATAATAATTTTGTTGAAGCTGTTATTGCCTTGCCTGATAATCTTTTTTATGGAACAAGCATTGCAACCTATATTTTAGTTTTGGCAAAAAATAAACCTGAGGATAAAACACTTTTTATTGATGCTTCTTCAGATGAAAAATCTACGGTTTCTGGTAAGAATAAATTTTATGAGACAGTAACCAATGGCAAGATATTAAACCCGAAAAATATCGAAGCTATTGTTGAATTATTTAAGAATAAAAAAGATGTCGATTATGAGGCTAAACTTGTCGATAATAATCTGATTGCTGAAGAAAATGATTACAATTTATCTGTATCAACCTATGTCGAAAAGCGTGACACACGCGAAATTATCAATATTGATGAACTCAACAAAGAAATTGCTGAAACGGTTAAGAAGATTGATCATCTACGCAGTGAGATTGATAAAATTGTGGAGGAGCTGAGCCATGACTAA","4.70","-25.37","60583","MSFNKESQQRQELHQKIWAIADNVRGAVDGWDFKQYILGILFYRFISENMSDYFDRAEHEAGDPDFRYADLSDEEAEEDFKPDTVEEKGFFILPSQLFENIVKTASTNENLNTDLAKIFKKIEESAIGKDSEHAIKGLFDDVDTTSNRLGGSVKEKNKRLSDILTGIAGLDFGTFEENDIDAFGDAYEYLISNYASNAGKSGGEFFTPQTVSKLLAQLVMVGKEHINKVYDPTCGSGSLLLQMKKQFETHILEEGFFGQEINMTNYNLARMNMFLHNINYNNFDIRRGDTLLNPQHLYERPFDAIVSNPPYSIKWIGDADPTLINDERFAPAGKLAPKSKADFAFIMHSLSHLSNKGRAAIVCFPGIFYRGGAEKTIRQYLIDNNFVEAVIALPDNLFYGTSIATYILVLAKNKPEDKTLFIDASSDEKSTVSGKNKFYETVTNGKILNPKNIEAIVELFKNKKDVDYEAKLVDNNLIAEENDYNLSVSTYVEKRDTREIINIDELNKEIAETVKKIDHLRSEIDKIVEELSHD","846899","For other 'hsd' genes see SMu0814 (hsdS) and SMu0818 (hsdR). From Genbank:[gi:135199]This enzyme is involved in the methylation of specific adenine residues.It is required for both restriction and modification activities.","type I restriction-modification system DNA methylase","Cytoplasm","Several matches in gapped BLAST to type I restriction-modification system DNA methylase: residues 8-531 are 63% similar to the enzyme in E.coli (gi|2121159|). Residues 6-531 are 62% similar to the protein from Neisseria meningitidis (gi|15676726|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1280 (3e-05).","

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[305-311]?$	N6_MTASE

InterPro
IPR002296
Family

N6 adenine-specific DNA methyltransferase, N12 class
PR00507	$\"[203-219]T$ $\"[229-243]T$ $\"[302-314]T$ $\"[340-364]T$	N12N6MTFRASE

InterPro
IPR003356
Domain

N-6 DNA methylase
PF02384	$\"[178-500]T$	N6_Mtase

InterPro
IPR004546
Family

Type I restriction-modification system M subunit
TIGR00497	$\"[9-521]T$	hsdM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[205-417]T$	G3DSA:3.40.50.150
PTHR18895	$\"[212-311]T$	PTHR18895
SSF53335	$\"[205-510]T$	SSF53335

","BeTs to 6 clades of COG0286COG name: Type I restriction-modification system methyltransferase subunitFunctional Class: LThe phylogenetic pattern of COG0286 is -Mt-----e-rhUJ-p-----Number of proteins in this genome belonging to this COG is 1","***** PR00507 (N12 class N6 adenine-specific DNA methyltransferase signature) with a combined E-value of 5.1e-28. PR00507A 203-219 PR00507B 229-243 PR00507C 302-314 PR00507D 340-364","Residues 78-175 are 56% similar to a (TYPE PLASMID RESTRICTION SUBUNIT) protein domain (PD011415) which is seen in Q47163_ECOLI.Residues 27-249 are 24% similar to a (RESTRICTION ENZYME PROTEOME COMPLETE) protein domain (PD116700) which is seen in Q9ZM08_HELPJ.Residues 181-269 are 78% similar to a (RESTRICTION TYPE ENZYME PROTEOME) protein domain (PD002294) which is seen in Q9JV16_NEIMA.Residues 271-470 are 63% similar to a (RESTRICTION TYPE ENZYME METHYLTRANSFERASE) protein domain (PD002458) which is seen in Q47163_ECOLI.Residues 79-180 are 57% similar to a (I TYPE RESTRICTION SYSTEM) protein domain (PD404617) which is seen in Q9JV16_NEIMA.Residues 8-73 are 63% similar to a (RESTRICTION TYPE PROTEOME ENZYME) protein domain (PD004658) which is seen in Q9P9Z2_XYLFA.Residues 482-531 are 68% similar to a (RESTRICTION TYPE PROTEOME ENZYME) protein domain (PD036168) which is seen in Q47163_ECOLI.Residues 9-173 are 25% similar to a (SUBUNIT TYPE PLASMID MODIFICATION) protein domain (PD116698) which is seen in Q9ZJ91_HELPJ.Residues 11-176 are 23% similar to a (M SUBUNIT RESTRICTION-MODIFICATION) protein domain (PD355689) which is seen in Q50358_MYCPU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:27:04 2002","Fri Jan 25 13:22:57 2002","Sat Oct 12 12:27:04 2002","Wed Jan 2 15:58:25 2002","Wed Jan 2 15:58:25 2002","Wed Jan 2 15:58:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0813 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 16:00:53 2002","","No significant hits to the NCBI PDB database.","SMU.891","","Residues 9 to 262 (E-value = 9e-116) place SMu0813 in the Methylase_M family which is described as Type I restriction modification system, M protein (PF02506)Residues 313 to 485 (E-value = 6.4e-71) place SMu0813 in the N6_Mtase family which is described as N-6 DNA Methylase (PF02384)","Wed Jan 2 15:58:25 2002","24379344","","","Tyndall,C., Meister,J. and Bickle,T.A.The Escherichia coli prr region encodes a functional type IC DNArestriction system closely integrated with an anticodon nucleasegeneJ. Mol. Biol. 237 (3), 266-274 (1994)PubMed: 8145241Price,C., Lingner,J., Bickle,T.A., Firman,K. and Glover,S.W.Basis for changes in DNA recognition by the EcoR124 and EcoR124/3type I DNA restriction and modification enzymesJ. Mol. Biol. 205 (1), 115-125 (1989)PubMed: 2784505","","Wed Jan 2 16:02:19 2002","1","","","SMU.891","" "SMu0814","846893","848704","1812","ATGACTAAAATTGATGACATGATCAAAGACCTCTGTCCAGATGGTGTGGAATGGAAAAAGTTATGGGAAGTGACAATTTGGGATAAAAAATTTAATAGTGTTCCAAAATTTAAACAGCAATTAGTTGATAAATATGAGTATTTGCTTGCTAAAGACCTCTCTCAAATGGTGGTCTCAGGTGGGGATATTAAAATATTGACAACCAGTCCAAGTAATTTATGGACAACGGAGTATGTTGCAGGAGGGGAGTTTTTTGATAAAGAAATAGTTGCAATACCATGGGGAGGTAATCCCATTGTTCAGTATTACAAAGGTAAATTTATTACAGGTGACAACAGAATTGCCAGAGTAAAAAATGATGATGAATTGTTAACCAAATACTTATATTATTATTTACAAAATAATTTGAAATTAATTTCAAGTTTTTATAGAGGCTCTGGGATACAACATCCAGATATGTCGAAAGTTTTAGATACAAAGATTCCCATTCCACCCCTAGAAATTCAAGAAGAAGTCGTTAAAATACTTGACAAATTCACCGATTATGTCACAGAATTGACCTCAGAATTGACCTTACGCCAAAAGCAATATTCTTTTTATCGCGATAAACTGCTGTCTTTTGAAGATGAGATTTATCAAGTGGAGTGGAAGACGCTGGAGGAAATTTCTGTTCCTATAAAAAACATATCGTGGAAGGAAAACTCTGAAAGAACATATTCTTATATAGACCTTTCTTCTGTTGATAGAGAAAGTAAAAAAATAACAGACATAACAACAATCACGGCTGATAAAGCACCAAGTAGGGCGCAAAGAATTGTAAAAACTGATGATATTATTTTTGGAACGACGAGGCCAACTCTTAGAAGATTTGCTAAAGTTCCTGAAAATTTCAATAATCAGATTTGCAGTACAGGATTTTATGTGTTTCGTGCCTCTAACGAAGTTCTTCCGAGCTATATCTATCATATTTTTGCTTCCAATGATTTTAATAGCTATGTTGAAAAAAATCAGAGTGGAGCTAGCTACCCAGCAATAGCAGATAGTTTAGTTAAAAAGTACAAATTACCAGTTCCATCTCTCAAAATCCAATCTCGCATTGTCCAAGTCCTTGATAATTTTGATACGGTTTGTAATGACCTTAACATCGGACTTCCCAAAGAAATCGAACTTCGTCAAAAACAGTATGAATATTTTAGAGATAAACTCTTGACCTTCACCGCCGAAGGCGTGTACACTGACAGTACAGTACAGTACAGACAAGACCTGATTAGGCTCTTGCAGTGGGTCTTTGGACCAATTAAGGTTAGTCTGGGGAGTATTTGTAGTATTTCACGAGGTAAGAGACTTATTAGAAGTCAGCTAAATAAAAATGGCAAATATCCTGTTTATCAAAATAGTCTTATTCCTTTGGGTTACTTTAATGAAACGAATGAGGAAGCTAATACCACATTTGTTATTAGTGCAGGTGCTGCTGGTGAAATTGGATTTAGTAAACAACCTTTTTGGAAAGCTGATGATGTATGGACAATGAGTTCTGAATTTATCAATCAAAGATTTTTATATTATATGCTTTTGAGCAATCAATCTAAGATTAAAGGCCAAGTAAGAAAGGCTAGTATACCGAGATTATCTAAAAATGTAATTGAAAATTTAACAGTTTGTCTACCTGAAAGTGAAGGCCAATCCCGCATTGTTTCCGTTTTAGACAAATTTGACACTTTGATCAATTCTATCTCTGAGGGATTACCCAAGGAAATTGAATTAAGACAGAAACAATATGAGTATTTTAGAGATAAGTTGTTGAGTTTTTAG","8.50","4.30","69774","MTKIDDMIKDLCPDGVEWKKLWEVTIWDKKFNSVPKFKQQLVDKYEYLLAKDLSQMVVSGGDIKILTTSPSNLWTTEYVAGGEFFDKEIVAIPWGGNPIVQYYKGKFITGDNRIARVKNDDELLTKYLYYYLQNNLKLISSFYRGSGIQHPDMSKVLDTKIPIPPLEIQEEVVKILDKFTDYVTELTSELTLRQKQYSFYRDKLLSFEDEIYQVEWKTLEEISVPIKNISWKENSERTYSYIDLSSVDRESKKITDITTITADKAPSRAQRIVKTDDIIFGTTRPTLRRFAKVPENFNNQICSTGFYVFRASNEVLPSYIYHIFASNDFNSYVEKNQSGASYPAIADSLVKKYKLPVPSLKIQSRIVQVLDNFDTVCNDLNIGLPKEIELRQKQYEYFRDKLLTFTAEGVYTDSTVQYRQDLIRLLQWVFGPIKVSLGSICSISRGKRLIRSQLNKNGKYPVYQNSLIPLGYFNETNEEANTTFVISAGAAGEIGFSKQPFWKADDVWTMSSEFINQRFLYYMLLSNQSKIKGQVRKASIPRLSKNVIENLTVCLPESEGQSRIVSVLDKFDTLINSISEGLPKEIELRQKQYEYFRDKLLSF","848703","For other 'hsd' genes see SMu0813 (hsdM) and SMu0818 (hsdR). ","type I restriction-modification system specificity determinant","Cytoplasm","Several matches in gapped BLAST to type I restriction enzyme S protein: residues 1-405 are 27% and residues 267-603 are 28% similar to the enzyme in Xylella fastidiosa (gi|15839315|). Residues 324-603 are 30% and residues 145-405 are 29% similar to the protein from Helicobacter pylori (gi|15645467|).SMu0814 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000055
Domain

Restriction modification system DNA specificity domain
PF01420	$\"[16-181]T$ $\"[214-375]T$ $\"[432-573]T$	Methylase_S

","BeTs to 5 clades of COG0732COG name: Restriction endonuclease S subunitsFunctional Class: LThe phylogenetic pattern of COG0732 is aMt-----e-rHUJgP-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 173-209 are 58% similar to a (RESTRICTION TYPE SYSTEM SPECIFICITY) protein domain (PD301451) which is seen in T1S1_ECOLI.Residues 232-358 are 29% similar to a (I PROTEOME SYSTEM) protein domain (PD263112) which is seen in Q9P9Z8_XYLFA.Residues 181-222 are 57% similar to a (RESTRICTION SUBUNIT TYPE HSDS) protein domain (PD079114) which is seen in Q47280_ECOLI.Residues 541-592 are 45% similar to a (RESTRICTION ENZYME TYPE SPECIFICITY) protein domain (PD332753) which is seen in Q47280_ECOLI.Residues 50-197 are 26% similar to a (RESTRICTION ENZYME MODIFICATION PROTEOME) protein domain (PD358878) which is seen in Q9JN06_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:28:01 2002","Fri Jan 25 13:23:42 2002","Sat Oct 12 12:28:01 2002","Wed Jan 2 16:12:05 2002","","Wed Jan 2 16:12:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0814 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 16:15:16 2002","","No significant hits to the NCBI PDB database.","SMU.892","","Residues 16 to 181 (E-value = 1.5e-15) place SMu0814 in the Methylase_S family which is described as Type I restriction modification DNA specificity domain (PF01420)Residues 214 to 375 (E-value = 9.3e-13) place SMu0814 in the Methylase_S family which is described as Type I restriction modification DNA specificity domain (PF01420)Residues 432 to 573 (E-value = 2e-16) place SMu0814 in the Methylase_S family which is described as Type I restriction modification DNA specificity domain (PF01420)","Wed Jan 2 16:12:05 2002","24379345","","","Price,C., Lingner,J., Bickle,T.A., Firman,K. and Glover,S.W.Basis for changes in DNA recognition by the EcoR124 and EcoR124/3type I DNA restriction and modification enzymesJ. Mol. Biol. 205 (1), 115-125 (1989)PubMed: 2784505Meister,J., MacWilliams,M., Hubner,P., Jutte,H., Skrzypek,E.,Piekarowicz,A. and Bickle,T.A.Macroevolution by transposition: drastic modification of DNArecognition by a type I restriction enzyme following Tn5transpositionEMBO J. 12 (12), 4585-4591 (1993)PubMed: 8223468","","Wed Jan 2 16:15:16 2002","1","","","SMU.892","" "SMu0815","848735","849880","1146","ATGAAAGAATTGAATCGTTTAGAAGATGTTGCTGTTGAGTTAAGAGACTCAAGTAAAAATATTAAATTAGTTTATGCCTTTAATGGAACAGGAAAAACCAGACTATCTATGTTGTTTAAAAACTTGATTCAACCTCAAATAGATATTGAAGCTGGAGCAAATTTTTTAAAGAAAATTTTGTACTATAATGCTTTTACTGAAGATCTCTTTACCTGGGATAATGATCTTGAAAATGGAAGTGAACGAAAATTATTAATCAATGTGAATTCTGAATGGATTAAAAAAATTATTACAATAGAAGGAGATAGTGCCCGTATTGTAGAAAAATTTCAGGACTACGTTCTTGAAGACAAGGAAGATATTTCAGAAAAAATCGAGGCAGAATTCAATGCTGATGTAACAGCGGTCTCTTTTAGAAGAAGCTACCAAGGCAATCTTTCAGAAAATATAAAAATTTCGAGAGGGGAAGAGAGCAATTTTATTTGGTCTGTTTTCTACATCCTCATGGAATTTATCATTGAGCAACGTAGTTCAGAAGAAGATAGACGAACACATGAGTATGATGAACTGGAATATATCTTTATAGATGATCCTGTTTCTTCTTTAGATGATCGGAGAATCATTGATGTAGCTCTAGATCTAGCCTATCTTTTAAAAGAAAGTGATAAAAATGATACTGGATTAAAATTTATTATCACTACTCATCACGCTTTATTTTTTAACGTCCTTTTTAATGAATTGAAGAAAAGTAGTAGCAAATTTTTATTGAAAAAAACAAATCAGAAATACCTACTGAATTCTCAAGATAACGATGCTCCGTTTGCTTATCATTTGATGCTTGTAGATGAACTTAAAAAGGCTATTGCAGAGGATAGAGTTGAGAAATATCATTTCAACTTATTGCGTAACTTGTTAGAAAAAACTGCAACTTTTCTAGGTTATAAAAATTGGGGTGCTTGTGTCATTTTGAGGGATGAAGATGGAAATCTAGAAGAGCCCGCTCCTTATATTCGCCGTATTAATCTACATAGTCATAGTGCACACTCAGATTATGAAACTAGAGCATTAACAACTCAGGAAAAAAAGGTCTTAGAACGTGTCTTTAATCAATTTCTTCAGAATTTTAGCTTTAATAATGTAGAATAA","5.00","-14.07","44676","MKELNRLEDVAVELRDSSKNIKLVYAFNGTGKTRLSMLFKNLIQPQIDIEAGANFLKKILYYNAFTEDLFTWDNDLENGSERKLLINVNSEWIKKIITIEGDSARIVEKFQDYVLEDKEDISEKIEAEFNADVTAVSFRRSYQGNLSENIKISRGEESNFIWSVFYILMEFIIEQRSSEEDRRTHEYDELEYIFIDDPVSSLDDRRIIDVALDLAYLLKESDKNDTGLKFIITTHHALFFNVLFNELKKSSSKFLLKKTNQKYLLNSQDNDAPFAYHLMLVDELKKAIAEDRVEKYHFNLLRNLLEKTATFLGYKNWGACVILRDEDGNLEEPAPYIRRINLHSHSAHSDYETRALTTQEKKVLERVFNQFLQNFSFNNVE","849879","This enzyme triggers the cleavage ligation of tRNA (Lys).It is activated by T4 STP protein [gi:131023].","anticodon nuclease","Cytoplasm, Extracellular","Limited matches in gapped BLAST to anticodon nuclease: residues 12-365 are 42% similar to the enzyme in E.coli (gi131023). Residues 7-365 are 43% similar to the protein from Neisseria meningitidis (gi15676728).SMu0815 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF52540	$\"[7-332]T$	SSF52540

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 12-365 are 42% similar to a (NUCLEASE ANTICODON PROTEOME COMPLETE) protein domain (PD138764) which is seen in PRRC_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:24:16 2002","Fri Jan 25 13:24:16 2002","Thu Sep 28 14:16:40 2006","Wed Jan 2 16:18:41 2002","","Wed Jan 2 16:18:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0815 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 16:20:20 2002","","No significant hits to the NCBI PDB database.","SMU.893","","No significant hits to the Pfam 11.0 database","Wed Jan 2 16:18:41 2002","24379346","","","Levitz,R., Chapman,D., Amitsur,M., Green,R., Snyder,L. andKaufmann,G.The optional E. coli prr locus encodes a latent form of phageT4-induced anticodon nucleaseEMBO J. 9 (5), 1383-1389 (1990)PubMed: 1691706Jiang Y, Blanga S, Amitsur M, Meidler R, Krivosheyev E, Sundaram M, Bajji AC, Davis DR, Kaufmann G.Structural features of tRNALys favored by anticodon nuclease as inferred from reactivities of anticodon stemand loop substrate analogs.J Biol Chem. 2002 Feb 8;277(6):3836-41.PMID: 11723135","","Sat Oct 12 12:32:14 2002","1","","","SMU.893","" "SMu0816","849954","850226","273","ATGGTTGTAAAAAATAAAGCAAATATCAATATCAAAATTGATTTGGAAGATAAAGCAGCAGCGGATGCTATTTTTGCTCACATGGGTCTAACAACAAGTGCTGCTGTTAATATGTTTATTAAACGTGTCATTGATGATCAAGCTCTGCCATTTACTCCAAGAGTAAAAAATACTTTGGACATTGCTTTAGAGCAGGCTAAAAATGATGATGTTGAAACTTTTGATAGTTTTGATGATTGGAAATCAGAGATGAGTGCCTATGCTAAAGATTAA","4.50","-4.77","10035","MVVKNKANINIKIDLEDKAAADAIFAHMGLTTSAAVNMFIKRVIDDQALPFTPRVKNTLDIALEQAKNDDVETFDSFDDWKSEMSAYAKD","850225","SMu0816 is a possible DNA-damage-inducible protein.","conserved hypothetical protein","Periplasm, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins from S.pneumoniae: residues 5-86 are 28% similar to (gi|15900209|) and (gi|15902296|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0435 (1e-04).","

InterPro
IPR007337
Family

RelB antitoxin
PF04221	$\"[6-86]T$	RelB
TIGR02384	$\"[1-84]T$	RelB_DinJ

InterPro
IPR007712
Family

Plasmid stabilization system
PF05016	$\"[4-90]T$	Plasmid_stabil

InterPro
IPR012753
Family

Addiction module toxin, RelE/StbE
TIGR02385	$\"[3-90]T$	RelE_StbE

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:36:57 2002","Thu Jan 3 08:16:18 2002","Fri Jan 25 13:36:57 2002","Thu Jan 3 08:16:18 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0817 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 13:36:57 2002","","No significant hits to the NCBI PDB database.","SMU.896","","Residues 1 to 90 (E-value = 4.4e-19) place SMu0817 in the DUF332 family which is described as Domain of unknown function (DUF332) (PF03890)","Thu Jan 3 08:16:18 2002","24379348","","","","","","1","","","SMU.896","" "SMu0818","850494","853541","3048","ATGAAATCAGTAGATTACTCAAAGGTAGTTCTTCCTGTTGCAGAGTTAACCAATGGGATTATTTTAGAAGAATTTGTAAAAACAGAGCGTTATAATCGAGATGTCTATCAGACTGAAAATGAAATGGAAAAGAAACTGATAGAAGATCTGGTCCAAGGCCAGCATTACGAATTATTAACAATTCACACAGCAGAAGAATTAATGATTAATTTGCGTGAGCAAATAGAAAAGCTTAATAATGTAACGTTTACAAATGATGAATGGCAGCGTTTTTTAGATGAATATTTGGATCGTCCTAATGATGGGATGATTGAAAAAACTCGTAAAATTCAAGAGAATCATATTTATGATTTTATTTTTGATGATGGGCATATTAAAAATATTATATTGATTGATAAGAAAAATATTCATCAGAATCATTTACAAGTTGTAAGTCAAATTAGGCAAAAAGGAAGTCATTCTAACCGTTATGATGTGACAATTTTAGTCAATGGTCTGCCCCTAGTACAGATTGAATTAAAAAAACGTGGTATTCCAATGAAGGAGGCCTTTGAACAGATTCATCGTTATAGCAAAGAATCCTTTAACACTCAACATTCACTTTTTCAGTATATTCAAATTTTTGTTATTTCAAATGGGACGCGGACACGTTATTTTGCCAATACAACTGCTCAAAATAAAAATCATTTTGAATTTACCTGTGAATGGGCAGATAAAAAGAATAAAATTATTTATGATTTAGAAGATTTTGCACAAACTTTTTTAAATAAGCAAGTTCTTTTATCCGTTTTGACAAAGTATTGTGTTTTTGATACTAGTGATACTCTTTTGATCATGCGTCCCTATCAAATTGCAGCAACAGAAGCCATTATGCGTCAGATCCATGTTGCGCACGAAAATAAACTCTATGGTACAACTGAAGCAGGAGGATTTATTTGGCATACTACTGGTTCTGGTAAAACTCTGACAAGTTTTAAAGCTGCACGTTTAGCAACAGAATTAGATTATATTGACAAGGTTTTCTTTGTTGTTGACCGTAAAGATTTAGATTATCAGACCATGAAGGAATATCAGAAGTTTCAAAAGGATTCTGTTAATGGTAGTAAAAATACTAAAGAATTAAAAAGAGCTATTGAGAAGAATGATAGTAAAATTGTTGTGACAACAATTCAGAAATTAAATGAATTCGTCAAGAAAAATCCTGAACATCCTATCTTTGAAAAGCAATGTGTTTTAATTTATGATGAGTGCCATCGCTCTCAATTTGGAGATACTCAAAGAAAGGTTAGGTCTAGTTTTAGAGCACATTATCAGTTTGGTTTTACAGGTACACCAATCTTTGAAGATAATACTTTAACAGGTATGTTGACAAGTACTATTTTTGGTAAGCAGCTTCATTCCTATATTATCACAGATGCTATTCGTGATAACAAAGTGTTGAAATTTAAGGTGGATTATAATTATATTAAACCAGAACTAAATAAATTTAGAGAAGCCGAAGTAACATCTGGACAAGAAAATGATAAAAAGAAGCTTAAAAAAATTGAAAAAGAACTACTTTTACATCCGGAGCGTATTTCAACAATTTCAGAATATTTACTTAAAGTATTTGATGATAAAACCCATCGAAATGTGCATTATACTCATAAACAAAAACAACTTAAAGGCTTTAATGCTATGTTTGCGGTACAAAATGTTAAAGCGGCGAAAGCTTATTATGAAGAGATCAATAAGCAACAAAGACAATTGCCAGTAGATAAAAGAATCAAAATTGCTACTATTTATAGTTATGTGCCTAATGAAGAACAGTTAGCATACGGGGCTATAGATTCAGAAAACTTTGAACCAACGAAAATGGATCTTTCTTCAAAAGAATTCTTAGATTTGGCTATATCTGACTACAATAAACACTTTAAAACAAATTTCTCAACAGAAGGAAAGGATTTCCAAAATTATTATAAAGATTTAACCAAACGTGTAAAATCCAAAGAAGTAGATCTTTTGATTGTGGTAGGAATGTTTTTAACAGGCTTTGATGCTCCTACTTTGAATACACTCTTTGTAGATAAAAATTTACGATATCATGGGCTTATTCAAGCATTTTCTCGTACAAATCGTATTTTAAATAAAGAAAAGCCATTTGGGAATATTGTTTGCTTCCGTGATTTAGAAAAAGCTACTAATGATGCTTTGACACTTTATGGTGAATCACACAGTATTTCGGTAGTACTTGAGAAGAGTTACGAAGAATATATGTCTGGTTTTACAGATAAAGAAACTGGTATTACAGTAAAAGGTTATCAAGAGGTTTGTCAGGAAATACTTGAAAAATTTCCTGATCCAACAGAAATTACTCTAGAATCTGAAAAACGAGAATTTGTTAAATTGTTTGGGGAAGTCCTTAAGTTAGAGAATGTTTTAAGAAATTATGATGAATTTACGCCAGAAGAGCATCTCATTACACCAGGTCAAATGCAGGACATGAGAAGTGTATATGTAGATATTCGAGAAGAAGCATATGGAAATGGTCGAACTGGTAAAAATGAAGAAACTGGTATTGATTTATCCGATATAGAATTTGAAATTGAACTTTTAAAAACGGATGAGATTAACCTTGATTATATTATTAGTCTTATCTCTGCAAAAGCACAAGATAATGATTCTAAGGAAACATTAAAACGGGATATTAGTCGTGTTATTCGTTCAAGCATTGATATGCGAGCTAAAGAAGAACTAGTGATTGGATTTATTAATGAAACACACTTAGAACAATTAAAAGATAATCAGACAATATTAGAAGCTTTTTATGCTTATGGTAATCAGAAGAAAAAGAAAGCTATAGAGGATTTAGCTGAAGAGCTTACATTAAAGGGAGACTATCGTCGATTTATTAATCGTTCTATTGCTCAGGGATATGTATCGTCTTCTGGTACTGACATTAATAATCTAATGCCAGCTACCTCGCGTCGAAAGGGTGCCCGTGAACGTAAGAAACACGAAATTTTAGTAAAATTACAAAAACTAGTGGAGACTTATACAGGGATTTAA","7.00","0.00","118435","MKSVDYSKVVLPVAELTNGIILEEFVKTERYNRDVYQTENEMEKKLIEDLVQGQHYELLTIHTAEELMINLREQIEKLNNVTFTNDEWQRFLDEYLDRPNDGMIEKTRKIQENHIYDFIFDDGHIKNIILIDKKNIHQNHLQVVSQIRQKGSHSNRYDVTILVNGLPLVQIELKKRGIPMKEAFEQIHRYSKESFNTQHSLFQYIQIFVISNGTRTRYFANTTAQNKNHFEFTCEWADKKNKIIYDLEDFAQTFLNKQVLLSVLTKYCVFDTSDTLLIMRPYQIAATEAIMRQIHVAHENKLYGTTEAGGFIWHTTGSGKTLTSFKAARLATELDYIDKVFFVVDRKDLDYQTMKEYQKFQKDSVNGSKNTKELKRAIEKNDSKIVVTTIQKLNEFVKKNPEHPIFEKQCVLIYDECHRSQFGDTQRKVRSSFRAHYQFGFTGTPIFEDNTLTGMLTSTIFGKQLHSYIITDAIRDNKVLKFKVDYNYIKPELNKFREAEVTSGQENDKKKLKKIEKELLLHPERISTISEYLLKVFDDKTHRNVHYTHKQKQLKGFNAMFAVQNVKAAKAYYEEINKQQRQLPVDKRIKIATIYSYVPNEEQLAYGAIDSENFEPTKMDLSSKEFLDLAISDYNKHFKTNFSTEGKDFQNYYKDLTKRVKSKEVDLLIVVGMFLTGFDAPTLNTLFVDKNLRYHGLIQAFSRTNRILNKEKPFGNIVCFRDLEKATNDALTLYGESHSISVVLEKSYEEYMSGFTDKETGITVKGYQEVCQEILEKFPDPTEITLESEKREFVKLFGEVLKLENVLRNYDEFTPEEHLITPGQMQDMRSVYVDIREEAYGNGRTGKNEETGIDLSDIEFEIELLKTDEINLDYIISLISAKAQDNDSKETLKRDISRVIRSSIDMRAKEELVIGFINETHLEQLKDNQTILEAFYAYGNQKKKKAIEDLAEELTLKGDYRRFINRSIAQGYVSSSGTDINNLMPATSRRKGARERKKHEILVKLQKLVETYTGI","853540","For other 'hsd' genes see SMu0813 (hsdM) and SMu0814 (hsdS).","type I restriction-modification system,helicase subunits","Cytoplasm","Several matches in gapped BLAST to type I restriction-modification system,helicase subunits: residues 13-1015 are 52% similar to the enzyme in Haemophilus influenzae (gi|16273673|). Residues 142-881are 31% similar to the protein from S.pyogenes (gi|15675717|).SMu0818 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004473
Family

Type I restriction modification system site-specific deoxyribonuclease HsdR
TIGR00348	$\"[39-740]T$	hsdR

InterPro
IPR006935
Family

Type III restriction enzyme, res subunit
PF04851	$\"[276-447]T$	ResIII

InterPro
IPR007409
Domain

Type I restriction enzyme R protein N terminus
PF04313	$\"[36-227]T$	HSDR_N

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[275-485]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[301-463]T$	HELICASE_ATP_BIND_1

","BeTs to 6 clades of COG0610COG name: Restriction enzymes type I helicase subunits and related helicasesFunctional Class: LThe phylogenetic pattern of COG0610 is aMt-----e--HUJ-P-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 440-750 are 58% similar to a (RESTRICTION TYPE PROTEOME COMPLETE) protein domain (PD003073) which is seen in Q9JZZ7_NEIMB.Residues 138-295 are 66% similar to a (RESTRICTION TYPE ENZYME COMPLETE) protein domain (PD003712) which is seen in Q9JZZ7_NEIMB.Residues 767-971 are 21% similar to a (RESTRICTION ATP-BINDING SYSTEM TYPE) protein domain (PD132523) which is seen in T1RX_MYCPN.Residues 314-433 are 70% similar to a (RESTRICTION TYPE ENZYME COMPLETE) protein domain (PD003184) which is seen in T1R1_ECOLI.Residues 430-486 are 43% similar to a (RESTRICTION PROTEOME COMPLETE TYPE) protein domain (PD392155) which is seen in Q9PR49_UREPA.Residues 13-122 are 44% similar to a (RESTRICTION TYPE PROTEOME SYSTEM) protein domain (PD037177) which is seen in T1R1_ECOLI.Residues 772-838 are 41% similar to a (RESTRICTION TYPE PROTEOME COMPLETE) protein domain (PD337179) which is seen in Q9ZKZ8_HELPJ.Residues 857-1004 are 36% similar to a (RESTRICTION TYPE PROTEOME COMPLETE) protein domain (PD041103) which is seen in T1R1_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:33:44 2002","Fri Jan 25 13:38:05 2002","Sat Oct 12 12:33:44 2002","Thu Jan 3 08:21:13 2002","","Thu Jan 3 08:21:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0818 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 08:21:39 2002","","No significant hits to the NCBI PDB database.","SMU.897","","Residues 36 to 227 (E-value = 1.4e-52) place SMu0818 in the HSDR_N family which is described as Type I restriction enzyme R protein N terminus (HSDR_N) (PF04313)","Thu Jan 3 08:21:13 2002","24379349","","","Price,C., Lingner,J., Bickle,T.A., Firman,K. and Glover,S.W.Basis for changes in DNA recognition by the EcoR124 and EcoR124/3type I DNA restriction and modification enzymesJ. Mol. Biol. 205 (1), 115-125 (1989)PubMed: 2784505","","Thu Jan 3 08:22:58 2002","1","","","SMU.897","" "SMu0819","853755","854129","375","ATGGAAATTGTACGTCAAAAGGAATTTGTTAACCAATATCATTATGATGCCAGAAATTTAGAATGGGAAAAGGAAAACGGGACACCTGAAACAGATGTTGAAGTGACTTTTCAATTAGTTGAAAAAAATGAAGAGTTAAATGAAACGACTGTTGTGGCCGTTTTGCAATTCATGATTGTCCGTGATGAGTTTGTTCTAAGCGGTGTTCTTTCACAAATGGTTAAGATTAAAGACCGTTTGGTTAATCAGCCAAGTGAATTTTCACAAGAGGAAGTTGCGACTTTAGCGGCGCCTCTGCTTGATATTTTAAAACGCATGACCTATGAAGTGACTGAAATTGCGCTTGATAAAGAAGGCGTTAGCTTGGAGTTCTAA","4.20","-12.75","14382","MEIVRQKEFVNQYHYDARNLEWEKENGTPETDVEVTFQLVEKNEELNETTVVAVLQFMIVRDEFVLSGVLSQMVKIKDRLVNQPSEFSQEEVATLAAPLLDILKRMTYEVTEIALDKEGVSLEF","854128","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins:residues 1-124 are 73% similar to S.pyogenes (gi|15674892|) and 58%similar to S.pneumoniae (gi|15901401|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1343 (7e-50).","

InterPro
IPR009530
Family

Protein of unknown function DUF1149
PIRSF031568	$\"[1-124]T$	UCP031568
PF06619	$\"[1-124]T$	DUF1149

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-124 are 53% similar to a (PROTEOME COMPLETE) protein domain (PD397017) which is seen in Q9CFB8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 13:40:17 2002","Thu Jan 3 08:30:13 2002","Fri Jan 25 13:40:17 2002","Thu Jan 3 08:30:13 2002","","Thu Jan 3 08:30:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0819 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 13:40:17 2002","","No significant hits to the NCBI PDB database.","SMU.898","","Residues 1 to 124 (E-value = 4.9e-94) place SMu0819 in the DUF1149 family which is described as Protein of unknown function (DUF1149) (PF06619)","Thu Jan 3 08:30:13 2002","24379350","","","","","","1","","","SMU.898","823" "SMu0820","854135","854980","846","ATGAAATTAGCTGTAATTACTGATTCATCAGTCTACCTTCCTCAAGACTTTGTTCAAAGAGAAGATCTTTTTATCCTTGATATTGATATTACTATTGATGGAAAGACATATATTGAAGGTAAAAATCTATCTCTTGATGAATTCTATACTAAGATGGCTGCTTCCAAGGAATTACCCAAGACGAGCCAGCCTAATTTGGCTGAGTTAGATGATTTACTGACCAACTTGGAAGAAGAAGCCTATACCCATGTTATCGGTCTTTTTCTGTCTGGTGGCATTTCGGGATTTCACCAAAATATTCAATATCTAATTGCTGAACATGATAAGCTTGAAATTGCCTTTCCTGATACTAAAATCACTTCCAGTCCTATGGGATTAATGGTAATGGAGGCTTTGAAGTGGGGCAGGGAAGAAATAGCTTTTGAGCAGATTTTGGTCAATCTTCAAGTGATGATTGATAAAACCAATGCTTTTATTATGGTTGACGATCTGAATCATCTGGTTAAAGGCGGCCGTTTGTCAAATGGTTCGGCTCTCTTAGGTAATCTTTTGAGTATCAAGCCTATCCTTTATTTTACGAATGGCAGGATTGAAGTTTTTGAGAAAGTTAGAACTGAGAAAAAAGCGATTAAGCGTTTAATCTCTATTATAGATGAGGTTACTGCTGATGGGTCTTATATGGTCTATATTATTCATGCCAATGCTAGAGGTAAGGCAGAAGATTTGCAGAAGCGTTTAGTTGATCATGGTTATACAAAGAATCTTGCCATTGTTCCTTTCAATGGTGTTATTGCAACCCATCTGGGTGAGGGAGCTATTGCACTTGGTGCTATACCAATTATTTAA","5.00","-9.30","31222","MKLAVITDSSVYLPQDFVQREDLFILDIDITIDGKTYIEGKNLSLDEFYTKMAASKELPKTSQPNLAELDDLLTNLEEEAYTHVIGLFLSGGISGFHQNIQYLIAEHDKLEIAFPDTKITSSPMGLMVMEALKWGREEIAFEQILVNLQVMIDKTNAFIMVDDLNHLVKGGRLSNGSALLGNLLSIKPILYFTNGRIEVFEKVRTEKKAIKRLISIIDEVTADGSYMVYIIHANARGKAEDLQKRLVDHGYTKNLAIVPFNGVIATHLGEGAIALGAIPII","854979","","conserved hypothetical protein, DegV family","Cytoplasm, Membrane","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 1-279 are 52% similar to S.pyogenes (gi15674893).Residues 1-281 are 50% similar to S.pneumoniae (gi15903458).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1342 (6e-74).","

InterPro
IPR002035
Domain

von Willebrand factor, type A
PR00453	$\"[26-43]T$ $\"[188-196]T$	VWFADOMAIN

InterPro
IPR003797
Family

DegV
PF02645	$\"[72-280]T$	DegV
TIGR00762	$\"[3-280]T$	DegV

noIPR
unintegrated

unintegrated
G3DSA:3.30.1180.10	$\"[154-275]T$	G3DSA:3.30.1180.10
SSF82549	$\"[1-279]T$	SSF82549

","BeTs to 4 clades of COG1307COG name: Uncharacterized protein, DegV familyFunctional Class: SThe phylogenetic pattern of COG1307 is ------V--Br---GP-----Number of proteins in this genome belonging to this COG is 3","***** IPB003797 (DUF194) with a combined E-value of 2.2e-12. IPB003797A 61-97 IPB003797C 170-192 IPB003797D 259-269","Residues 200-269 are 40% similar to a (PROTEOME COMPLETE BH3627 DEGV) protein domain (PD400373) which is seen in Q9CFB9_LACLA.Residues 2-132 are 41% similar to a (PROTEOME COMPLETE PLASMID MG326) protein domain (PD007382) which is seen in Q9CFB9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 12 16:31:47 2006","Wed Jul 12 16:31:47 2006","Wed Jul 12 16:31:47 2006","Thu Jan 3 08:32:59 2002","Thu Jan 3 08:32:59 2002","Thu Jan 3 08:32:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0820 is paralogously related (blast p-value < 1e-3) to SMu0148, and SMu0533, both predicted conserved hypothetical proteins.","Fri Jan 25 13:41:13 2002","","No significant hits to the NCBI PDB database.","SMU.899","","Residues 72 to 280 (E-value = 2.2e-69) place SMu0820 in the DUF194 family which is described as Uncharacterized protein, DegV family COG1307 (PF02645)","Thu Jan 3 08:32:59 2002","24379351","","","","","","1","","","SMU.899","822" "SMu0821","854992","855759","768","ATGAGTATTAAAGTTATTGTTGCAGGTTTTAAAGGCAGAATGGGGTCAACGGCTGTTGATATGATTAAAAATGATAGCGAGCTTGAATTGGCAGCACTTTTGGATCCTTTTGCAGCTGAAAAAGAAATTGATGGAGTGCCTGTCTTTACGGATAAGAGTGACCTTGTTGGCCTTGATGCTGAGGTTTGGGTTGATTTTACTATCCCTAAAGTCGCTTATGAAAATACACATTTTGCCCTTGAAAATGGTTTTCGTCCAGTTGTGGGAACAACAGGTTTTACGCAAGAGCAGATTGCAGATTTAATGACTTTGTCTGCTGATAAAAAATTGGGCGGTTTGATTGCACCAAATTTTGCTATTGGAGCTGTTTTGCTGATGGAATTTGCTGCTAAGGCTTCTAAGTATTTCCCTGATCTTGAAATCATTGAATTGCATCATGATAAGAAAAAGGATGCTCCAAGCGGAACAGCAGTTAAAACAGCTGAGCTTATTCGAGAAGCACGTGCTTATAAAAAACAGGGGGCAGCAGATGAAGAAGAAACGCTAGTTGGTGCACGCGGTGCTGAATTTGATGGTTTTAGAATTCATAGTGTTCGTTTGCCGGGTCTTGTTGCTCACCAAGAGGTCATCTTTGGTGCCCAAGGAGAAGGTTTGACGCTGCGTCATGATTCTTATGATCGGATTTCTTTTATGAGTGGTGTTAATTTAGGAATCAAAGAAGTGGTACAGCGAGAGCAGCTCGTTTATGGTTTGGAACATTTACTATGA","4.90","-10.30","27791","MSIKVIVAGFKGRMGSTAVDMIKNDSELELAALLDPFAAEKEIDGVPVFTDKSDLVGLDAEVWVDFTIPKVAYENTHFALENGFRPVVGTTGFTQEQIADLMTLSADKKLGGLIAPNFAIGAVLLMEFAAKASKYFPDLEIIELHHDKKKDAPSGTAVKTAELIREARAYKKQGAADEEETLVGARGAEFDGFRIHSVRLPGLVAHQEVIFGAQGEGLTLRHDSYDRISFMSGVNLGIKEVVQREQLVYGLEHLL","855758","For other 'dap' genes see SMu0900 (dapA) and SMu1763 (dapE).","dihydrodipicolinate reductase","Cytoplasm","Several matches in gapped BLAST to dihydrodipicolinate reductase: residues 1-255 are 74% similar to the enzyme in S.pneumoniae (gi|15901398|). Residues 3-255 are 67% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673543|).SMu0821 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000846
Family

Dihydrodipicolinate reductase
PD004105	$\"[52-255]T$	DapB
PF01113	$\"[3-118]T$	DapB_N
PF05173	$\"[121-255]T$	DapB_C
PS01298	$\"[140-157]T$	DAPB

InterPro
IPR011770
Family

Dihydrodipicolinate reductase, bacterial and plant
PIRSF000161	$\"[3-255]T$	DHPR
TIGR00036	$\"[2-255]T$	dapB

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[3-151]T$	G3DSA:3.40.50.720
PTHR20836	$\"[2-255]T$	PTHR20836
SSF51735	$\"[2-147]T$	SSF51735
SSF55347	$\"[119-227]T$	SSF55347

","BeTs to 12 clades of COG0289COG name: Dihydrodipicolinate reductaseFunctional Class: EThe phylogenetic pattern of COG0289 is amt--qvcebrhuj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB000846 (Dihydrodipicolinate reductase) with a combined E-value of 8.5e-67. IPB000846A 4-15 IPB000846B 61-93 IPB000846C 110-125 IPB000846D 138-157 IPB000846E 197-234","Residues 182-255 are 72% similar to a (BIOSYNTHESIS DIHYDRODIPICOLINATE) protein domain (PD009584) which is seen in DAPB_LACLA.Residues 3-180 are 66% similar to a (BIOSYNTHESIS DIHYDRODIPICOLINATE) protein domain (PD004105) which is seen in DAPB_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:34:56 2002","Thu Jan 3 08:46:38 2002","Sat Oct 12 12:34:56 2002","Thu Jan 3 08:46:38 2002","Thu Jan 3 08:46:38 2002","Thu Jan 3 08:46:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0821 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 08:47:16 2002","Thu Jan 3 08:46:38 2002","pdb|1ARZ|D Chain D, Escherichia Coli Dihydrodipicolinate Reduct... 94 2e-020","SMU.900","","Residues 3 to 118 (E-value = 1.4e-41) place SMu0821 in the DapB_N family which is described as Dihydrodipicolinate reductase, N-terminus (PF01113)Residues 121 to 255 (E-value = 2.8e-61) place SMu0821 in the DapB_C family which is described as Dihydrodipicolinate reductase, C-terminus (PF05173)","Thu Jan 3 08:46:38 2002","24379352","","","Pavelka,M.S. Jr., Weisbrod,T.R. and Jacobs,W.R. Jr.Cloning of the dapB gene, encoding dihydrodipicolinate reductase,from Mycobacterium tuberculosisJ. Bacteriol. 179 (8), 2777-2782 (1997)PubMed: 9098082Bouvier,J., Richaud,C., Richaud,F., Patte,J.C. and Stragier,P.Nucleotide sequence and expression of the Escherichia coli dapBgeneJ. Biol. Chem. 259 (23), 14829-14834 (1984)PubMed: 6094578Scapin,G., Blanchard,J.S. and Sacchettini,J.C.Three-dimensional structure of Escherichia coli dihydrodipicolinate reductaseBiochemistry 34 (11), 3502-3512 (1995)PubMed: 7893645Scapin,G., Reddy,S.G., Zheng,R. and Blanchard,J.S.Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylateBiochemistry 36 (49), 15081-15088 (1997)PubMed: 9398235","","Thu Jan 3 08:55:37 2002","1","","","SMU.900","" "SMu0822","855756","856961","1206","ATGAGATTAAAACATTTGCCTTCTGAATTTCAGGAGGCTTTACCAGTATTAGAGAAAATTAAGGCAGCAGGATTTGAAGCTTATTTTGTTGGCGGCAGTGTTCGTGATGTCCTTTTAGGGCATCCTATTCATGATGTTGACATTGCCAGCAGCTCTTATCCTGAAGAGACGAAAAAAATTTTTCCTCGGACGGTTGATATTGGCATTGAACACGGAACTGTTTTGGTTTTAGAGAATGGTCATGACTATGAAGTGACAACTTTTCGTACCGAAGATCTTTATGTTGATTATCGCAGACCCAGTCAGGTCTCTTTTGTACGTTCTTTAGAAGAGGATCTCAAACGGCGTGACTTTACTATCAATGCTTTTGCGCTTGATGAAAAGGCTAATATTATTGATAAATTTAATGGTCTAGTGGACTTGGAGCAAAAGATTTTACGGGCAGTCGGCAATGCTGCTGAACGTTTCAATGAAGATGCCTTGCGTATTATGCGTGGTTTGCGCTTTGCTGCTCAATTAAATTTCGATATTGAGAAAAAAACGTTCATAGCTATGAGAGAACATGCGCCCTTGCTGGAAAAAATTTCTGTAGAGCGCTCTTTTATTGAGTTCGACAAGCTCTTACGGGCTCCTTATTGGCGTAAGGGAATAAATTGTTTAATTGCCAGTCAAGCTTATGATTATCTGCCTTTATTGCAAAGTACTGCGGATAAGTGGCAGCAGCTGTTGACGGATTTGCCAGAGGATTTCACTTTTTCAACCTCTGAACAAGCTTGGGCGGCAGTACTGTTGTATTTGAATGTTGAAAATCCTAGATCCTTCTTAAAAAGTTGGAAAACCTCTAATGATTTTCAAAAAACGGTGGAAAAACTTCTAGCTATTTATAGATTGCGCGAGGATAGACAAATCAAAAAAACTGATGTTTACCAATATAGTGCAACTTTGTTAACCCTTGTTGAAGAATTGCGTCAAGCTCAGGGTTTAGCAGTTGATTTTGAGCACATTAAAGAGCTGGATGAAGCGTTAACCATTCATGACAAGCATGAAATTGTGGTTAAGGGTGGCGATTTGATGGCGGCCTTTGATTTGAAACCAGGACCAGACTTAGGAAAAATCTTGAACCAAATTGAAAGTTTTATTGTTGCTGGAAATTTAGCCAATGAACGACAAGCAATTTTGGATTTTGTCAGAAAGGAAATCGACTAA","5.30","-10.83","46071","MRLKHLPSEFQEALPVLEKIKAAGFEAYFVGGSVRDVLLGHPIHDVDIASSSYPEETKKIFPRTVDIGIEHGTVLVLENGHDYEVTTFRTEDLYVDYRRPSQVSFVRSLEEDLKRRDFTINAFALDEKANIIDKFNGLVDLEQKILRAVGNAAERFNEDALRIMRGLRFAAQLNFDIEKKTFIAMREHAPLLEKISVERSFIEFDKLLRAPYWRKGINCLIASQAYDYLPLLQSTADKWQQLLTDLPEDFTFSTSEQAWAAVLLYLNVENPRSFLKSWKTSNDFQKTVEKLLAIYRLREDRQIKKTDVYQYSATLLTLVEELRQAQGLAVDFEHIKELDEALTIHDKHEIVVKGGDLMAAFDLKPGPDLGKILNQIESFIVAGNLANERQAILDFVRKEID","856960","This enzyme creates the 3' poly(A) tail found in some mRNAs.It seems to be involved in plasmid copy number control [gi:1709578].","CCA-adding enzyme; tRNA nucleotidyltransferase","Cytoplasm","Several matches in gapped BLAST to poly(A) polymerase: residues 6-400 are 66% similar to the enzyme in S.pyogenes (gi15674894). Residues 6-399 are 65% similar to the protein from S.pneumoniae (gi15901397).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1341 (1e-150).","

InterPro
IPR002646
Domain

Polynucleotide adenylyltransferase region
PF01743	$\"[27-147]T$	PolyA_pol

InterPro
IPR012222
Family

Poly-A polymerase/tRNA nucleotidyltransferase
PIRSF000814	$\"[1-400]T$	PolyA_pol

noIPR
unintegrated

unintegrated
G3DSA:1.10.3090.10	$\"[146-321]T$	G3DSA:1.10.3090.10
G3DSA:3.30.460.10	$\"[11-144]T$	G3DSA:3.30.460.10
PTHR13734	$\"[45-279]T$	PTHR13734
PTHR13734:SF5	$\"[45-279]T$	PTHR13734:SF5
SSF81301	$\"[6-144]T$	SSF81301
SSF81891	$\"[145-398]T$	SSF81891

","BeTs to 12 clades of COG0617COG name: tRNA nucleotidyltransferase/poly(A) polymeraseFunctional Class: JThe phylogenetic pattern of COG0617 is ----yQvCEbrHuj--oLINxNumber of proteins in this genome belonging to this COG is 1","***** IPB002646 (Poly A polymerase family) with a combined E-value of 9.2e-39. IPB002646A 28-47 IPB002646B 108-123 IPB002646C 147-173 IPB002646D 195-208","Residues 216-392 are 44% similar to a (POLYA POLYMERASE COMPLETE PROTEOME) protein domain (PD103772) which is seen in Q9CFC2_LACLA.Residues 30-208 are 70% similar to a (COMPLETE PROTEOME NUCLEOTIDYLTRANSFERASE) protein domain (PD003898) which is seen in Q9CFC2_LACLA.Residues 30-211 are 48% similar to a (PROTEOME COMPLETE TRNA TRANSFERASE) protein domain (PD377189) which is seen in O83294_TREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 14:38:20 2006","Wed Sep 13 17:01:58 2006","Wed Sep 13 17:01:58 2006","Thu Jan 3 09:09:33 2002","Thu Jan 3 09:09:33 2002","Thu Jan 3 09:09:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0822 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 09:09:48 2002","","No significant hits to the NCBI PDB database.","SMU.901","","Residues 85 to 238 (E-value = 1.8e-55) place SMu0822 in the PolyA_pol family which is described as Poly A polymerase family (PF01743)","Thu Jan 3 09:09:33 2002","24379353","","","","","","1","","","SMU.901","405" "SMu0823","856964","858832","1869","ATGAGTGATTTTATTGTTGAACGGTTAAGCAAAACAGTTGGCGATAAGACTGTCTTTCAGAATATTTCTTTTATTATCCATGATAAGGATCGTATTGGAATCATTGGTGTCAATGGGACTGGAAAGACCACTCTTCTTGATGTTATCTCTGGTAGATTAGGATTTGATGGCGACAACTCACCTTTTTCTGCTAAAAACGACTATAAGATGGCTTATCTAACGCAAGAACCTGTTTTTAATGAGACGAAGACAATTCTTGATACAGTCTTGTCATCAGATTTGCGGGAAATGCAGCTCATTCACACTTATGAATCGTTCATGGCCAATTATGATGAAGCTAATCAGGAGCAATTGGAAAAGGTTATGGCAGAAATGGATGCTCTAGATGTCTGGTCTATTGAAAGTGAAGTCAAAACTGTTTTGTCTAAATTAGGGATTTCTGATTTATCGCAAAAAGTTGGCAACCTGTCAGGCGGCTTGAAGCGGCGCGTGCAATTAGCTCAGGTTTTACTAAATGATGCAGACTTGCTTTTGCTGGATGAGCCGACCAATCACCTTGATATTGATACCATTGCTTGGCTGGCTAATTTTTTAAAAAACAGCAAAAAAACGGTTCTTTTTATTACGCATGATCGCTATTTCTTGGACAGTATTGCCAGCCGTATTTTTGAATTGGATAGGGCGCATTTGATTGAATATCAGGGCAATTATCAAGATTATGTGCGCCTGCGTGCAGAACAGGATGAACGCGACGCGGCAGCTTTACATAAGAAAAAGCAGCTCTACAAACAAGAACTGGCTTGGATGCGTAGGCAGCCACAGGCGCGTGCGACAAAACAAGAAGCGCGTATCAATCGTTTTAAGAATTTAAAATCAGACTTATCTGGTATGGATACTTCTTCTGATCTTGAAATCAATTTTCAAACCAGTCGTATCGGAAAAAAGGTTATCAATTTTGAACAGGTAGACTTTGCTTATCCCGATAAAACGATTTTGACACATTTTAATTTACTCATTCAAAACAAAGACCGAATTGGCATTGTTGGCGAAAATGGGGTTGGAAAATCAACTCTTTTACATTTAATGAATGGCGACTTGCAGCCAAATTCTGGAAAGCTGGATATTGGTGAGACGGTTCGTATTGGCTACTTCTCCCAGCAAATCAAAGATATGGACGAAAACAAGCGTGTGATTAACTATTTGCAGGAAGTGGCAGATGAGGTTACAACAGCTGTTGGGATAAGCAGTGTGACTAGTCTCTTAGAGCAATTTCTCTTCCCGCGCTCAACACACGGAACACTTATTTCTAAGTTGTCAGGCGGTGAGAAGAAACGTCTTTATTTACTCAAAATCCTAATTGAAAAGCCCAATGTCTTGCTCTTAGATGAGCCGACCAACGACCTTGATATTGCGACTTTGACAGTTCTTGAGAGTTTCTTGCAGGATTTTTCTGGTCCTGTCATTACGGTTAGTCATGACCGTTATTTTCTAGACAAAGTAGCCAATAAAATCCTCGCTTTTGAACATAATGCCATCCGTGAATTTTTTGGCAATTATACCGATTATTTAGATGAGAAAGCGTTTGAAAAAGACAGTTCTGCCATGGTAGTCAAAAAAGAAGCAGCAAAGGTTGAGAAAGAAAAGTCAGAGCGTAAACGTATGTCTTATTTTGAAAAGCAAGAATGGGCGACGATTGAAGATGATATAACAGCTTTAGAGGAAAGAATCGAAAACATTGAGGCGACCATGCAGGAACATGCTTCAGATTATGGTCAGCTGGCTGGTTTGCAGCGTGATTTAGATACTGCCAATGAGCAGCTCCTTGAAAAATATGAGCGTTATGAATACTTGAGCGAACTGGAGAAATAA","5.00","-21.02","71157","MSDFIVERLSKTVGDKTVFQNISFIIHDKDRIGIIGVNGTGKTTLLDVISGRLGFDGDNSPFSAKNDYKMAYLTQEPVFNETKTILDTVLSSDLREMQLIHTYESFMANYDEANQEQLEKVMAEMDALDVWSIESEVKTVLSKLGISDLSQKVGNLSGGLKRRVQLAQVLLNDADLLLLDEPTNHLDIDTIAWLANFLKNSKKTVLFITHDRYFLDSIASRIFELDRAHLIEYQGNYQDYVRLRAEQDERDAAALHKKKQLYKQELAWMRRQPQARATKQEARINRFKNLKSDLSGMDTSSDLEINFQTSRIGKKVINFEQVDFAYPDKTILTHFNLLIQNKDRIGIVGENGVGKSTLLHLMNGDLQPNSGKLDIGETVRIGYFSQQIKDMDENKRVINYLQEVADEVTTAVGISSVTSLLEQFLFPRSTHGTLISKLSGGEKKRLYLLKILIEKPNVLLLDEPTNDLDIATLTVLESFLQDFSGPVITVSHDRYFLDKVANKILAFEHNAIREFFGNYTDYLDEKAFEKDSSAMVVKKEAAKVEKEKSERKRMSYFEKQEWATIEDDITALEERIENIEATMQEHASDYGQLAGLQRDLDTANEQLLEKYERYEYLSELEK","858831","For other components see SMu0826 (MSD2). ","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several matches in gapped BLAST to ABC transporter, ATP-binding protein: residues 1-621 are 69% similar to the protein in S.pyogenes (gi|15674895|)and are 70% similar to the protein from S.pneumoniae (gi|15901396|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1340 (0.0).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[155-198]T$ $\"[438-480]T$	ABC_transporter
PF00005	$\"[29-228]T$ $\"[342-510]T$	ABC_tran
PS50893	$\"[4-252]T$ $\"[317-534]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-235]T$ $\"[341-516]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-233]T$ $\"[316-562]T$	G3DSA:3.40.50.300
PTHR19211	$\"[128-587]T$	PTHR19211
PTHR19211:SF7	$\"[128-587]T$	PTHR19211:SF7
SSF47655	$\"[566-616]T$	STAT
SSF52540	$\"[6-239]T$ $\"[317-577]T$	SSF52540

","BeTs to 10 clades of COG0488COG name: ATPase components of ABC transporters with duplicated ATPase domainsFunctional Class: RThe phylogenetic pattern of COG0488 is ----Y--CEBRHuj--olinxNumber of proteins in this genome belonging to this COG is 4","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.8e-21. IPB001140A 331-377 IPB001140B 435-473 IPB001140C 487-516","Residues 556-619 are 51% similar to a (ATP-BINDING ABC COMPLETE PROTEOME) protein domain (PD031335) which is seen in Q9CFC6_LACLA.Residues 414-477 are 43% similar to a (ABC TRANSPORTER ABC-TRANSPORTER) protein domain (PD330281) which is seen in Q9F901_STRPN.Residues 245-326 are 57% similar to a (ATP-BINDING ABC TRANSPORT TRANSPORTER) protein domain (PD331541) which is seen in Q9CFC6_LACLA.Residues 249-331 are 40% similar to a (ATP-BINDING ABC PROTEOME TRANSPORTER) protein domain (PD005562) which is seen in O06476_BACSU.Residues 381-437 are 63% similar to a (PROTEOME COMPLETE TRANSPORT TRANSPORTER) protein domain (PD019163) which is seen in Q9CFC6_LACLA.Residues 435-480 are 52% similar to a (PROTEOME BINDING ATP-BINDING COMPLETE) protein domain (PD335182) which is seen in Q9X7B1_MYCLE.Residues 327-380 are 53% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD382315) which is seen in Q9CFC6_LACLA.Residues 297-371 are 34% similar to a (FIS FLJ11198 EAKLY CDNA:) protein domain (PD060943) which is seen in Q9H7A8_HUMAN.Residues 483-526 are 61% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME COMPLETE REPEAT) protein domain (PD000796) which is seen in Q9CFC6_LACLA.Residues 331-398 are 33% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD220985) which is seen in Q9KFD1_BACHD.Residues 201-514 are 23% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 317-407 are 45% similar to a (PROTEOME TRANSPORTER ATP-BINDING COMPLETE) protein domain (PD245664) which is seen in Q9KBM6_BACHD.Residues 419-508 are 38% similar to a (ATP-BINDING) protein domain (PD397028) which is seen in Q53712_STRAT.Residues 69-144 are 48% similar to a (PROTEOME COMPLETE TRANSPORT TRANSPORTER) protein domain (PD337757) which is seen in Q9CFC6_LACLA.Residues 420-481 are 40% similar to a (ATP-BINDING RESISTANCE PLASMID COMPLETE) protein domain (PD019698) which is seen in Q9ZKZ3_HELPJ.Residues 1-68 are 66% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD387663) which is seen in Q9CFC6_LACLA.Residues 335-375 are 56% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9HZI7_PSEAE.Residues 438-480 are 90% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CFC6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 10:13:41 2002","Thu Jan 3 09:17:47 2002","Thu Oct 24 15:26:37 2002","Thu Jan 3 09:17:34 2002","Thu Jan 3 09:17:34 2002","Thu Jan 3 09:17:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0823 is paralogously related (blast p-value < 1e-3) to SMu1306, SMu1959, SMu0729, SMu1757, SMu0390, SMu0418, SMu0849, SMu1410, SMu1288, SMu0907, SMu1920, SMu0731, SMu1518, SMu0258, SMu1064, SMu1710, SMu1762, SMu1001, SMu1316, SMu0944, SMu0517, SMu1003, SMu1023, SMu0335, SMu0218, SMu1724, SMu0594, SMu0164, SMu0024, SMu0786, SMu1751, SMu1093, SMu0234, SMu1811, SMu1079, SMu1950, SMu0884, SMu1380, SMu1517, SMu1068, SMu1428, SMu0805, SMu0235, SMu0986, SMu0825, SMu1210, SMu0596, SMu1065, SMu1246, SMu1231, SMu0824, SMu0987, SMu0916, SMu1649, SMu0374, SMu0216, SMu1949, SMu0950, SMu1036, SMu0475, SMu1545, SMu0224, SMu0971, SMu0837, SMu0976, SMu0836, SMu1037, SMu1202, SMu0752, SMu0476, SMu0666, and SMu1050 all with ATP-binding capabilities.","Wed Mar 20 15:25:44 2002","","No significant hits to the NCBI PDB database.","SMU.902","","Residues 29 to 228 (E-value = 2.1e-37) place SMu0823 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 342 to 510 (E-value = 7.8e-30) place SMu0823 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Jan 3 09:17:34 2002","24379354","","","","","","1","","","SMU.902","144" "SMu0824","859289","861025","1737","ATGATATATATTTGGTCTTATTTAAAAAAATATCCCAAATGGTTACTATTGGACATTCTTGGTGCCCTTTTATTTGTTGTTGTCAATTTGGGCTTACCGACAGCTCTGGCACGAATGATTGATCAAGGGATCACACCGGCTGATAAACAAGCTCTTTATTTTTGGGCTTTTATTATGTTTATCATTGTTCTTTTAGGAATAGTCGGGCGTATTACCCTAGCCTATGCTTCTGGCAGATTAACCACGACCATGATTCGCGATATGCGCAATGATATGTATGATAAATTGCAAGAGTACTCCCATCACGAATATAAGAAAATTGGTGTCTCTTCCTTGGTTACACGTATGACCAGTGACGCCTTTGTACTTATGCAATTTGCAGAAATGTCCTTGCGGATGGGAATTGTTACCCCCTTGATGATGGTCTCAAGTGTTATTATGGTTTTGGTGACTAGCCCATCTTTGGCTTGGATTGTAGTATTTGCTATTCCTTTTTTGATACTGGTGATTTATTATGTTGCTGCAAAAACACGCCCTTTGTCTGAAAAGCAGCAAAATACGCTTGACAAGATTAATCAGTACGTTCGTGAAAACTTAACGGGTCTACGTGTTATTCGTGCCTTTGCGCGTGAAAATTTTCAAGAAGAACGCTTTGACTTAAAAAACAGAAGTTATGAAAAGACTTCTAACAGACTATTTAAATTAACCGGACTCACAGAAGCCCTGTTTGTTCAGATTATTATTATCATGATAGTAGCTATTGTTTGGTTTTCATTAGATCCGCTTAAGCAAGGGACTATTAAGATTGGTGATCTGGTTGCTTTTATTGAGTATAGTTTTCATGCTCTCTTTTCTTTTTTAATATTTGCTAATATTTTCACTATGTATCCGCGAATGGCTGTATCTAGCAAACGTATACAAGAGGTAATGGCTATGCCTATTTCCATTGATCCCAATATAAATGGCATTAAGGAGACTAAAACCAAAGGCTATTTGGAATTTGACAATGTGACCTTTGCCTATCCCGGTGAGACCGAAAGTCCTGTCTTGCATGATATTTCTTTTAAAGCTAGACCGGGAGAAACGATTGCTTTTATTGGCAGTACAGGTTCAGGAAAGTCGTCGCTTGTTAATTTGATTCCCCGTTTTTATGATGTAACTTTGGGTCGGATTCTGGTTGATGGTGTGGATGTCCGTGACTATAATCTTAAAGCTCTGCGTCAGAAAATTGGTTTTATTCCGCAAAAAGCGCTGCTATTTACTGGAACCATTGGAGAAAATCTTAAGTATGGGAAAAAGGATGCTAGTTTGGCTGAACTGCATTCAGCTGCTGATATTGCACAAGCTAAAGAATTCATCGAAAGTCGAGCTGAGAAATTTGATAGCCACTTAGCAGAAGGCGGCAGCAATCTTTCAGGAGGACAGAAGCAGCGCTTGTCTATTGCGCGTGCAGTTGTTAAGAAACCAGATATTTATATTTTTGATGATTCCTTTTCAGCCTTAGATTATAAGACAGATAGTCTCCTGCGTCAGCGTTTGAAAGAAGTGACAGGCAATTCAACAGTGCTCATTGTGGCCCAACGTGTCGGAACTATCATGAATGCTGACCAGATTATTGTACTGGATGAAGGAGAAATTGTTGGTCGCGGCAGCCATGATGAACTCATGAAGTCCAATGCCATTTATCGTGAAATTGCTAACTCACAACTCAATCAGCAAAGTTTAACGCAAGAGTAA","9.90","8.72","65158","MIYIWSYLKKYPKWLLLDILGALLFVVVNLGLPTALARMIDQGITPADKQALYFWAFIMFIIVLLGIVGRITLAYASGRLTTTMIRDMRNDMYDKLQEYSHHEYKKIGVSSLVTRMTSDAFVLMQFAEMSLRMGIVTPLMMVSSVIMVLVTSPSLAWIVVFAIPFLILVIYYVAAKTRPLSEKQQNTLDKINQYVRENLTGLRVIRAFARENFQEERFDLKNRSYEKTSNRLFKLTGLTEALFVQIIIIMIVAIVWFSLDPLKQGTIKIGDLVAFIEYSFHALFSFLIFANIFTMYPRMAVSSKRIQEVMAMPISIDPNINGIKETKTKGYLEFDNVTFAYPGETESPVLHDISFKARPGETIAFIGSTGSGKSSLVNLIPRFYDVTLGRILVDGVDVRDYNLKALRQKIGFIPQKALLFTGTIGENLKYGKKDASLAELHSAADIAQAKEFIESRAEKFDSHLAEGGSNLSGGQKQRLSIARAVVKKPDIYIFDDSFSALDYKTDSLLRQRLKEVTGNSTVLIVAQRVGTIMNADQIIVLDEGEIVGRGSHDELMKSNAIYREIANSQLNQQSLTQE","861024","For other components see SMu0825 (NBD1); SMu0824 (NBD2) and SMu0825 (MSD1).","ABC-type multidrug/protein/lipid transport system, ATPase component","Membrane, Cytoplasm","Matches in gapped BLAST to ABC transporter:residues 59-505 are 24% similar to the previously published protein in S.mutans (gi5918764) and (gi9802002). Several matches to ABC transporter, ATP-binding protein: residues 12-575 are 40% similar to the protein in Listeria innocua (gi16799691).Residues 13-573 are are 32% similar to the protein from S.pyogenes (gi15674417).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1338 (0.0).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[11-286]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[470-513]T$	ABC_transporter
PF00005	$\"[360-544]T$	ABC_tran
PS00211	$\"[471-485]T$	ABC_TRANSPORTER_1
PS50893	$\"[332-568]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[359-545]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[16-298]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[297-578]T$	G3DSA:3.40.50.300
PTHR19242	$\"[1-578]T$	PTHR19242
PTHR19242:SF91	$\"[1-578]T$	PTHR19242:SF91
SSF52540	$\"[332-573]T$	SSF52540
SSF90123	$\"[4-318]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 7.1e-62. IPB001140A 349-395 IPB001140B 468-506 IPB001140C 521-550","Residues 160-257 are 29% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD200980) which is seen in Q9CIU5_LACLA.Residues 152-342 are 23% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD168310) which is seen in Q9X144_THEMA.Residues 183-257 are 36% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD200991) which is seen in Q9WYC3_THEMA.Residues 131-339 are 23% similar to a (ATP-BINDING TRANSPORT MG014 TRANSMEMBRANE) protein domain (PD033674) which is seen in Y014_MYCGE.Residues 520-569 are 52% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD394504) which is seen in Q9ZIC8_LISMO.Residues 523-569 are 53% similar to a (ATP-BINDING ABC TRANSPORTER TRANSMEMBRANE) protein domain (PD405975) which is seen in Q9CIU5_LACLA.Residues 265-349 are 37% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in Q9L2F3_STRCO.Residues 406-468 are 41% similar to a (PROTEOME ATP-BINDING FUSION COMPLETE) protein domain (PD268678) which is seen in Q9I4M2_PSEAE.Residues 350-401 are 65% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in P71082_BACSU.Residues 470-513 are 68% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9L2F3_STRCO.Residues 320-430 are 26% similar to a (COMPLETE ORF MITOCHONDRION PROTEOME) protein domain (PD000146) which is seen in O77308_PLAFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:09:59 2005","Mon Oct 28 16:27:59 2002","Tue May 3 12:09:59 2005","Thu Jan 3 09:34:48 2002","Thu Jan 3 09:34:48 2002","Thu Jan 3 09:34:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0824 is paralogously related (blast p-value < 1e-3) to SMu0836, SMu0987, SMu0825, SMu0476, SMu0475, SMu0837, SMu0986, SMu0258, SMu1710, SMu1064, SMu1065, SMu1724, SMu0024, SMu1950, SMu1920, SMu1068, SMu1949, SMu1003, SMu0884, SMu1246, SMu1231, SMu0916, SMu1037, SMu0971, SMu1757, SMu0218, SMu0517, SMu0731, SMu1428, SMu0594, SMu0907, SMu0374, SMu0418, SMu1316, SMu0805, SMu0786, SMu1288, SMu1762, SMu0849, SMu1751, SMu1380, SMu1036, SMu0235, SMu1545, SMu1517, SMu1518, SMu1023, SMu0335, SMu0390, SMu0234, SMu1210, SMu1093, SMu1410, SMu0729, SMu0216, SMu0976, SMu0596, SMu0944, SMu1001, SMu1649, SMu0823, SMu0752, SMu1811, SMu1079, SMu0224, SMu1306, SMu0164, SMu1050, SMu1959, SMu1686, and SMu0666 all with ATP-binding capabilities.","Wed Mar 20 15:31:07 2002","Tue May 3 12:09:59 2005","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 82 2e-016pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 72 2e-013","SMU.905","","Residues 11 to 286 (E-value = 2.3e-40) place SMu0824 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 360 to 544 (E-value = 5.5e-51) place SMu0824 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue May 3 12:09:59 2005","24379355","","Qi,F., Chen,P. and Caufield,P.W.Purification of mutacin III from group III Streptococcus mutansUA787 and genetic analyses of mutacin III biosynthesis genesAppl. Environ. Microbiol. 65 (9), 3880-3887 (1999)PubMed: 10473390Qi,F., Chen,P. and Caufield,P.W.Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis GenesAppl. Environ. Microbiol. 66 (8), 3221-3229 (2000)PUBMED 10919773","","Wed Mar 20 15:30:40 2002","","1","","","SMU.905","143" "SMu0825","861036","862808","1773","ATGAAAAAGAAAACTGTCTTTTTACGCTTATGGTATTATTTGAAAACCTATAAAGGTTCACTCTTTTTGGCTATTTTTTTAAAAATACTTAGCAGTGTCATGAATGTCCTTGAGCCTTTTATTTTAGGACTGGTAATGACAGAATTAACGGCTAACTTAATTGATATGGCTCGCGGAGTTCAAGGCGCTCATCTCAATATCAGATATATTACCATGATTTTATTTCTTTATTTTTTACGTGGCTTGCTGTATAGTATTGGCTCTTACGGTTCTAATTACTTTATGACTAATGCAGTGCAAAAAAGCATTTACGATTTGCGTCATGATTTGAGTGAAAAGATTAATAAGATTCCCGTTTCTTATTTTGATAAACATCAATTTGGCGATATGTTAGGACGTTTCACTAATGACGTTGAAACAGTCTCCAACGCTTTACAGCAGAGCTTTCTGCAGATTATTAATGCTTTTTTGACAATTATCCTTGTTGTGGTTATGGTGCTTTACCTCAATTTGACTCTGGCGGCGATTATTCTTGTTTGTATTCCGCTGACTTATTTCAGTTCTCATTTTATTTTAAGGAAATCACAGCCTTATTTTAAAAAACAGGCTAATGCTTTAGGGGATATGAACAGTTTCGTTCAGGAAAACTTAACGGGCTTTAATGTCATAAAACTCTATGGACGTGAAGAAATATCTGCTGAAACCTTTCGAACTATCACAGAAAATTTACGAGATGTCGGCTTTAAAGCCAGTTTTATTTCTGGAATAATGATGCCAGTTCTTAATGCTATCTCAGACTTAGCTTATTTGATTGTTGCATTAGTTGGCGGCCTGCAGGTCTTAGCAGGGAGACTGACTATTGGTAATATGCAGGCCTTTGTTCAATACATTTGGCAAATCAATCAGCCTATTCAGACCATCACACAATTATCAAGTGTTCTTCAAAGTGCTAAATCTTCTCTAGAACGTATTTTTGAGGTTTTGGATGAAACAGATGAAGTCAATCAAGTCAAGGAAAAGCTGGAACATGATTTGACAGGGCAAGTGACCTTTCATAATGTCGCCTTTCAATATACTGAAGATAAGCCTTTAATTCGACATTTTGATTTAGATGTTAAACCGGGTCAGATGATTGCTGTTGTTGGTCCGACCGGGGCGGGTAAGACAACTCTTATCAATCTTTTGATGCGTTTTTATGATGTTACCCAAGGAGCGATTACAGTAGATAATCATGATATCCGTAACCTTTCCCGTCAGGAATATCGGAAACAATTTGGGATGGTTCTTCAAGATGCTTGGTTATATGAAGGGACGATCAAAGACAATTTGCGCTTTGGAAATTTGCAGGCAAGTGATGAGGAAATTGTCGAAGCAGCCAAGGCAGCTAATGTCGATCATTTTATCCGAACCCTTCCAGACGGTTATAATATGGAAGTCAATCAAGAATCTAATAATATTTCTTTGGGGCAAAAGCAATTGTTAACCATAGCACGAGCGCTGCTGGCTGATCCCAAAATTCTGATTCTGGATGAAGCGACTTCTTCAGTTGATACTCGTTTGGAACTTCTCATTCAAAAAGCTATGAGTAAGCTTATGGAAGGCCGCACTAGCTTTGTTATTGCTCATCGTCTTTCAACTATCCAAGAAGCCGATAAGATCCTTGTCCTTAAGGATGGTCAAATTATTGAACAGGGGAACCATCAAAGTCTCTTAGCTGACAAGGGCTTCTATTATGATTTGTATATGAGTCAGTTTAGCGCTAAAACCAATTAG","6.90","-0.37","66858","MKKKTVFLRLWYYLKTYKGSLFLAIFLKILSSVMNVLEPFILGLVMTELTANLIDMARGVQGAHLNIRYITMILFLYFLRGLLYSIGSYGSNYFMTNAVQKSIYDLRHDLSEKINKIPVSYFDKHQFGDMLGRFTNDVETVSNALQQSFLQIINAFLTIILVVVMVLYLNLTLAAIILVCIPLTYFSSHFILRKSQPYFKKQANALGDMNSFVQENLTGFNVIKLYGREEISAETFRTITENLRDVGFKASFISGIMMPVLNAISDLAYLIVALVGGLQVLAGRLTIGNMQAFVQYIWQINQPIQTITQLSSVLQSAKSSLERIFEVLDETDEVNQVKEKLEHDLTGQVTFHNVAFQYTEDKPLIRHFDLDVKPGQMIAVVGPTGAGKTTLINLLMRFYDVTQGAITVDNHDIRNLSRQEYRKQFGMVLQDAWLYEGTIKDNLRFGNLQASDEEIVEAAKAANVDHFIRTLPDGYNMEVNQESNNISLGQKQLLTIARALLADPKILILDEATSSVDTRLELLIQKAMSKLMEGRTSFVIAHRLSTIQEADKILVLKDGQIIEQGNHQSLLADKGFYYDLYMSQFSAKTN","862807","For other components see SMu0825 (NBD1); SMu0824 (NBD2) and SMu0824 (MSD2).","ABC transporter, ATP-binding / permease protein","Membrane, Cytoplasm","Matches in gapped BLAST to ABC transporter:residues 41-561 are 25% similar to the previously published protein in S.mutans (gi5918764) and (gi9802002).Several matches in gapped BLAST to ABC transporter, ATP-binding/permease protein: residues 85-590 are 49% similar to the protein in Clostridium acetobutylicum (gi15896526).Residues 1-580 are 38% similar to the protein from S.pneumoniae (gi15901211). This sequence is weakly similar to mutT from strain UA140 (see MI0008).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (0.0).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[21-304]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[485-528]T$	ABC_transporter
PF00005	$\"[375-559]T$	ABC_tran
PS00211	$\"[486-500]?$	ABC_TRANSPORTER_1
PS50893	$\"[349-583]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[374-546]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[22-316]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[314-584]T$	G3DSA:3.40.50.300
PTHR19242	$\"[7-586]T$	PTHR19242
PTHR19242:SF91	$\"[7-586]T$	PTHR19242:SF91
SSF52540	$\"[349-588]T$	SSF52540
SSF90123	$\"[1-363]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.1e-64. IPB001140A 364-410 IPB001140B 483-521 IPB001140C 536-565***** IPB001482 (Bacterial type II secretion system protein E) with a combined E-value of 2.4e-06. IPB001482B 374-396","Residues 530-563 are 73% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383) which is seen in Q9L2F2_STRCO.Residues 279-500 are 21% similar to a (ABC TRANSPORTER) protein domain (PD241124) which is seen in Q9U0N4_PLAF7.Residues 15-358 are 18% similar to a (TRANSPORT ATP-BINDING NIST PROTEOME) protein domain (PD018034) which is seen in SPAT_BACSU.Residues 70-361 are 21% similar to a (ATP-BINDING COMPONENT ABC TRANSPORT) protein domain (PD321417) which is seen in Q9L2K4_STRCO.Residues 173-280 are 25% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD200980) which is seen in Q9F6W3_CHLAU.Residues 161-358 are 25% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD168310) which is seen in Q9CAB3_ARATH.Residues 152-356 are 23% similar to a (ATP-BINDING TRANSPORT MG014 TRANSMEMBRANE) protein domain (PD033674) which is seen in Y014_MYCGE.Residues 162-264 are 25% similar to a (ATP-BINDING ABC PROTEOME TRANSPORTER) protein domain (PD260448) which is seen in Q9CG37_LACLA.Residues 13-342 are 20% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD401694) which is seen in Q9CFF6_LACLA.Residues 536-585 are 42% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD394504) which is seen in YFIB_BACSU.Residues 14-229 are 19% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD353690) which is seen in Q9KRY4_VIBCH.Residues 288-358 are 36% similar to a (ATP-BINDING TRANSPORT TRANSPORTER PEPTIDE) protein domain (PD168165) which is seen in Q9CC89_MYCLE.Residues 417-481 are 36% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760) which is seen in P73278_SYNY3.Residues 118-335 are 20% similar to a (ATP-BINDING TRANSPORT ABC COMPLETE) protein domain (PD009694) which is seen in Q9CKX7_PASMU.Residues 209-280 are 44% similar to a (ATP-BINDING ABC TRANSPORTER TRANSMEMBRANE) protein domain (PD348546) which is seen in Q9L2F2_STRCO.Residues 29-158 are 28% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348) which is seen in Q9KEN7_BACHD.Residues 283-362 are 38% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in P71082_BACSU.Residues 3-230 are 20% similar to a (ATP-BINDING PROTEOME PM1473 COMPLETE) protein domain (PD087458) which is seen in Q9CKX8_PASMU.Residues 417-479 are 38% similar to a (ABC PROTEOME BINDING COMPLETE) protein domain (PD387933) which is seen in Q9CG38_LACLA.Residues 3-365 are 19% similar to a (LTKB HOMOLOG) protein domain (PD168585) which is seen in O85327_SALTY.Residues 531-584 are 50% similar to a (ATP-BINDING TRANSPORT MULTIDRUG RESISTANCE-ASSOCIATED) protein domain (PD188719) which is seen in P73400_SYNY3.Residues 18-276 are 22% similar to a (BELONGS EXPORTER PRODUCT ABC) protein domain (PD119799) which is seen in Q48851_LACSK.Residues 365-414 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Y288_THEMA.Residues 170-281 are 27% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD396487) which is seen in Q9CIP5_LACLA.Residues 485-528 are 81% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CIU3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:10:27 2005","Mon Oct 28 11:45:44 2002","Thu May 5 11:30:36 2005","Thu Jan 3 09:37:07 2002","Thu Jan 3 09:37:07 2002","Thu Jan 3 09:37:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0825 is paralogously related (blast p-value < 1e-3) to SMu0837, SMu0986, SMu0476, SMu0475, SMu0824, SMu1710, SMu1065, SMu1064, SMu0258, SMu0836, SMu0987, SMu1724, SMu1950, SMu1380, SMu0024, SMu0418, SMu0971, SMu0517, SMu1762, SMu0731, SMu1210, SMu1920, SMu0805, SMu1079, SMu0916, SMu0235, SMu0390, SMu1003, SMu1023, SMu1949, SMu1246, SMu1231, SMu1316, SMu1545, SMu1410, SMu1757, SMu1037, SMu1036, SMu0849, SMu0335, SMu0594, SMu1428, SMu0786, SMu0218, SMu1288, SMu0216, SMu1518, SMu1068, SMu0224, SMu1649, SMu0884, SMu1751, SMu0374, SMu1517, SMu0596, SMu0907, SMu0976, SMu0234, SMu1001, SMu0164, SMu0944, SMu0950, SMu0823, SMu1306, SMu0752, SMu1811, SMu1093, SMu1050, SMu0666, SMu1959, SMu1202, SMu1725, SMu0729, and SMu1686 all with ATP-binding capabilities.See also MI0008, a mutacin I transporter in strain UA140.","Wed Apr 27 10:25:54 2005","Wed Apr 27 10:25:54 2005","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 74 4e-014pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 67 7e-012","SMU.906","","Residues 21 to 304 (E-value = 3.8e-47) place SMu0825 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 375 to 559 (E-value = 1.1e-57) place SMu0825 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Apr 27 10:25:54 2005","24379356","","Qi,F., Chen,P. and Caufield,P.W. Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes Appl. Environ. Microbiol. 65 (9), 3880-3887 (1999) PubMed: 10473390 Qi,F., Chen,P. and Caufield,P.W. Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis Genes Appl. Environ. Microbiol. 66 (8), 3221-3229 (2000) PUBMED 10919773 ","","Wed Mar 20 15:33:37 2002","","1","","","SMU.906","142" "SMu0826","862924","863844","921","ATGGCAATTGCAGGTTTAGTTTTTCAAAAGTTACTCGTTTTATTTTTGCTGATGCTAGCAGGATTATTTTTAGCGCAGCGGCAGATTTTAACCAAGGAGGTTACTTTACAGCTATCTAAACTGCTGACGCGTTTTGTTGCACCCAGTCTTTTTATTTCGTCTTTTATTTATCAAGCATTTACTTGGAAAAAAATGATTTTATTGTTTAGCATGATTGGGGCTGCTTTTTTTCTGCTTATTACTCGGATTGTTATTGTTTCATTTTTGCTTTCTAAAGAAAGGGCAACGGATAAATATGCTGTTCTTTTTGCTAACGTTGGTTTCATGGGAACTCCTTTGGCTTTTGCAGTTGGCGGTAAAGAAGCTGTTTTCTTTATTTCAGGATTCGTTGTAGCCAATCAAATTATGCAATGGACTTATGGCTTATACCTTATTGCTCAAGACAAAACTGTGATCAACTGGCGCTCTATTTTAGTCAATCCTGCTATGATAGCAACAGTCATTGGCCTCTTTCTTTTTATCCAGCCTTTTAAACTGCCTCTAGTAGCAAGAGATGCTATTGATGCTTTTGCTGATTTAAATACGCCTCTATCCACCATTGTCTTGGGTTCTTATTTCTATAAAGTAAAATTTAAAGAAGTTTTTCTTTACTGGCCCGCATATTATACTGCCTTTTTACGCTTGTTTGTTACGGCCTTAATCAGTATTTTAACGATCTGGTTATTGCCTATTCATTCGGATCCTGTAAAATTAGCCCTGTCAATTGCTGTTATTTCACCTGCTGCTTTAAACACGGCTCTCCTCAGTCAGGTTTATGGCGGAGAATATGAATATGGTTCGCGTCTGGTCTTGTTGACAACTGTTTTGTCTCTCCTGACCACTCCCTTAAATATGACTGTTGCTAGCTTATTGTATTTATAA","10.60","10.23","34138","MAIAGLVFQKLLVLFLLMLAGLFLAQRQILTKEVTLQLSKLLTRFVAPSLFISSFIYQAFTWKKMILLFSMIGAAFFLLITRIVIVSFLLSKERATDKYAVLFANVGFMGTPLAFAVGGKEAVFFISGFVVANQIMQWTYGLYLIAQDKTVINWRSILVNPAMIATVIGLFLFIQPFKLPLVARDAIDAFADLNTPLSTIVLGSYFYKVKFKEVFLYWPAYYTAFLRLFVTALISILTIWLLPIHSDPVKLALSIAVISPAALNTALLSQVYGGEYEYGSRLVLLTTVLSLLTTPLNMTVASLLYL","863843","For other components see SMu0823 (NBD1 and NBD2).","malate permease","Membrane, Cytoplasm","Limited matches in gapped BLAST to possible permease and hypotheticals: residues 30-275 are 26% similar to the protein in Clostridium acetobutylicum (gi|15896202|).Residues 38-280 are 21% similar to malate permease in Clostridium cellulovorans (gi|7363467|).SMu0826 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004776
Family

Auxin efflux carrier
PF03547	$\"[6-298]T$	Mem_trans

","BeTs to 5 clades of COG0679COG name: Predicted permeasesFunctional Class: RThe phylogenetic pattern of COG0679 is -mt-YqVceb----------xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 38-300 are 24% similar to a (PROTEOME COMPLETE PA0188 BH2670) protein domain (PD333104) which is seen in Q9K9H7_BACHD.Residues 38-280 are 22% similar to a (AUXIN TRANSPORT COMPLETE PROTEOME) protein domain (PD014028) which is seen in Q48797_OENOE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 16:29:28 2002","Mon Oct 28 16:30:22 2002","Mon Oct 28 16:29:28 2002","Thu Jan 3 09:43:13 2002","","Thu Jan 3 09:43:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0826 is paralogously related (blast p-value < 1e-3) to SMu0124, a predicted malate permease.","Fri Jan 25 13:45:37 2002","","No significant hits to the NCBI PDB database.","SMU.909","","Residues 6 to 298 (E-value = 4.8e-20) place SMu0826 in the Auxin_eff family which is described as Auxin Efflux Carrier (PF03547)","Thu Jan 3 09:43:13 2002","24379357","","","","","","1","","","SMU.909","" "SMu0827","864064","868452","4389","ATGGAAACCAAACGACGTTACAAAATGTACAAGGTTAAAAAGCACTGGGTAACCATTGCTGTCGCTTCTGGTTTGATTACCTTGGGCACCACAACACTGGGAAGCTCAGTTTCAGCAGAAACAGAACAGCAGACCTCAGATAAAGTGGTAACTCAGAAAAGTGAGGATGATAAGGCGGCATCTGAATCCAGCCAAACAGATGCACCTAAAACTAAGCAAGCACAAACAGAACAAACGCAGGCCCAAAGTCAGGCAAACGTTGCTGATACAAGCACTAGCATAACTAAGGAAACTCCTTCACAAAATATTACAACACAAGCCAACTCTGATGACAAAACAGTAACAAATACGAAATCAGAAGAAGCACAAACTTCTGAAGAGCGCACAAAGCAAGCAGAAGAAGCACAGGCTACTGCTTCCAGTCAGGCTTTAACACAGGCAAAAGCTGAATTAACAAAGCAAAGACAAACAGCAGCTCAAGAAAATAAAAATCCTGTTGACTTAGCGGCCATTCCAAATGTGAAACAAATTGATGGCAAATATTATTATATTGGTTCTGATGGTCAGCCTAAGAAAAATTTTGCTCTAACCGTTAATAACAAAGTACTCTACTTCGATAAAAATACAGGTGCCTTAACGGACACTTCTCAGTATCAATTTAAACAAGGGTTAACAAAATTAAACAACGATTATACTCCCCACAATCAAATTGTCAATTTTGAAAATACCAGTCTTGAAACGATTGATAACTATGTCACAGCTGATTCGTGGTATCGTCCTAAGGATATTTTAAAGAATGGCAAAACGTGGACAGCTTCATCTGAGTCTGATCTTCGTCCGCTTTTAATGTCTTGGTGGCCAGATAAACAAACGCAAATTGCTTATCTTAACTACATGAACCAGCAAGGACTTGGAACTGGTGAAAATTACACAGCAGACAGCAGCCAAGAAAGTCTCAACCTTGCTGCACAAACCGTTCAAGTTAAGATTGAAACTAAAATTTCTCAAACGCAGCAAACCCAGTGGCTGCGTGATATTATCAATAGTTTTGTTAAAACGCAACCAAATTGGAATAGTCAAACAGAATCGGATACTTCAGCTGGTGAAAAAGATCACTTGCAAGGCGGTGCTCTGCTTTACAGCAACAGCGATAAGACAGCCTATGCTAATTCCGATTACCGTCTTTTGAACCGCACACCAACCAGTCAAACGGGTAAACCAAAATATTTTGAAGACAATTCTTCTGGTGGCTATGACTTCCTCCTAGCTAATGATATTGATAATTCAAATCCAGTGGTTCAAGCTGAACAATTAAACTGGCTTCATTATCTGATGAATTATGGTTCTATTGTCGCTAATGATCCTGAGGCTAATTTTGACGGTGTTCGTGTTGATGCCGTTGATAATGTTAATGCCGACTTGCTGCAGATTGCTTCGGACTATTTGAAAGCCCATTATGGTGTTGATAAGAGTGAGAAAAATGCGATTAATCATCTTTCCATTTTAGAAGCTTGGTCAGATAATGATCCCCAATACAATAAAGATACTAAGGGTGCACAATTACCGATTGATAATAAACTGCGCCTATCGCTTTTATATGCTTTGACGCGTCCTCTTGAAAAAGATGCAAGCAATAAAAATGAAATTCGCAGCGGACTTGAGCCTGTCATAACAAATAGCTTGAATAACCGTTCAGCTGAAGGTAAAAATAGTGAACGTATGGCTAACTATATTTTTATCCGCGCTCACGACAGTGAAGTCCAAACGGTTATTGCTAAAATTATTAAAGCTCAGATTAATCCCAAAACAGATGGTTTGACCTTTACTTTGGATGAATTGAAGCAAGCCTTTAAGATCTACAATGAAGACATGCGTCAGGCTAAGAAAAAGTACACACAATCCAATATTCCGACAGCCTATGCTTTGATGCTGTCCAATAAAGATTCAATTACACGTCTTTATTATGGTGATATGTACAGTGATGACGGTCAATATATGGCGACTAAATCCCCTTATTATGATGCTATTGATACTTTATTAAAGGCACGTATTAAATATGCCGCCGGTGGTCAAGACATGAAGATCACCTATGTTGAAGGTGATAAAAGTCATATGGATTGGGATTATACAGGCGTTTTGACTTCTGTTCGTTATGGTACAGGAGCTAATGAAGCTACAGATCAAGGCAGTGAAGCAACCAAAACACAAGGAATGGCTGTCATTACCAGCAATAACCCTAGCCTTAAATTGAATCAAAATGATAAAGTAATTGTCAATATGGGGACTGCGCATAAAAATCAAGAGTACCGTCCGCTCCTCTTAACAACTAAAGATGGTTTGACAAGCTACACTTCTGATGCCGCTGCTAAATCCCTTTATCGCAAAACGAATGATAAAGGAGAATTAGTCTTTGATGCTAGTGACATTCAAGGTTACCTGAATCCGCAAGTATCAGGTTATTTAGCCGTTTGGGTTCCAGTAGGAGCTAGTGATAATCAAGATGTTCGTGTAGCAGCAAGCAATAAGGCAAATGCTACTGGTCAAGTCTACGAATCATCAAGTGCTCTTGATTCTCAATTGATTTATGAAGGCTTCTCAAACTTCCAAGATTTTGTGACGAAAGATTCAGACTATACTAATAAGAAGATTGCTCAAAATGTCCAACTCTTCAAATCTTGGGGTGTCACTTCCTTTGAAATGGCACCGCAATATGTCTCTTCTGAAGATGGTTCTTTTCTAGACTCTATTATTCAAAATGGTTATGCCTTTGAGGATCGTTATGATCTTGCTATGAGTAAGAATAACAAATACGGTTCTCAGCAAGACATGATTAATGCAGTTAAAGCTCTGCATAAAAGCGGTATTCAGGTTATTGCGGATTGGGTACCAGATCAAATCTATAATCTTCCGGGCAAAGAAGTCGTAACGGCTACACGTGTCAACGATTATGGTGAGTATCGCAAAGACTCTGAAATCAAAAATACACTCTATGCTGCCAACACTAAGAGTAATGGTAAGGATTATCAAGCGAAGTATGGCGGTGCTTTCCTTAGTGAACTCGCTGCTAAGTACCCTAGTATCTTTAACCGCACACAAATTTCAAATGGTAAGAAGATTGATCCAAGCGAAAAAATCACAGCATGGAAAGCAAAATACTTCAATGGGACAAATATTCTAGGCCGTGGTGTTGGTTATGTTCTTAAAGATAATGCTAGTGATAAATACTTTGAACTGAAAGGGAATCAAACCTATCTGCCAAAACAGATGACTAACAAAGAAGCTTCGACTGGTTTTGTTAATGATGGCAATGGGATGACTTTCTATTCAACTAGTGGTTATCAAGCCAAGAACAGCTTTGTTCAAGATGCCAAAGGAAACTGGTATTACTTTGATAATAATGGCCATATGGTTTATGGCTTGCAGCATCTAAATGGCGAAGTGCAATACTTTTTATCAAATGGTGTTCAATTGCGTGAATCTTTCTTGGAAAACGCTGATGGCAGCAAGAACTATTTTGGTCATCTAGGAAATAGATATAGTAATGGTTATTATTCATTTGATAATGATAGTAAGTGGCGTTATTTTGATGCCAGTGGAGTCATGGCTGTAGGTTTGAAAACAATTAACGGCAATACGCAGTACTTTGATCAAGATGGTTATCAAGTCAAAGGTGCTTGGATAACAGGCAGCGATGGCAAAAAGCGTTATTTTGATGACGGATCTGGAAATATGGCTGTTAATCGTTTTGCAAATGATAAAAACGGCGATTGGTACTATCTCAATTCAGATGGCATTGCCTTGGTTGGTGTCCAAACCATTAATGGTAAGACTTATTACTTTGGCCAAGATGGTAAGCAAATCAAAGGTAAAATTATTACAGACAATGGTAAGCTGAAATATTTCCTTGCCAATTCAGGAGAATTAGCACGCAATATCTTTGCAACAGACAGTCAAAACAATTGGTATTACTTTGGTTCAGACGGTGTTGCGGTTACAGGCAGTCAGACAATTGCTGGTAAAAAGCTCTATTTTGCAAGCGACGGAAAACAAGTCAAAGGCAGCTTTGTCACTTATAATGGTAAAGTTCATTATTATCATGCTGACTCAGGAGAATTACAAGTTAACCGCTTTGAAGCAGATAAGGATGGTAATTGGTATTATCTTGATTCAAATGGTGAAGCTCTGACAGGCAGCCAACGCATTAACGGTCAGCGTGTCTTCTTTACGCGAGAAGGAAAACAAGTTAAAGGTGATGTTGCTTATGATGAGCGAGGGCTTCTTCGTTATTATGATAAGAATAGTGGTAACATGGTTTACAACAAAGTCGTCACTTTAGCCAATGGAAGACGTATTGGCATTGACCGTTGGGGTATCGCTAGATATTATTAA","6.50","-4.25","163393","METKRRYKMYKVKKHWVTIAVASGLITLGTTTLGSSVSAETEQQTSDKVVTQKSEDDKAASESSQTDAPKTKQAQTEQTQAQSQANVADTSTSITKETPSQNITTQANSDDKTVTNTKSEEAQTSEERTKQAEEAQATASSQALTQAKAELTKQRQTAAQENKNPVDLAAIPNVKQIDGKYYYIGSDGQPKKNFALTVNNKVLYFDKNTGALTDTSQYQFKQGLTKLNNDYTPHNQIVNFENTSLETIDNYVTADSWYRPKDILKNGKTWTASSESDLRPLLMSWWPDKQTQIAYLNYMNQQGLGTGENYTADSSQESLNLAAQTVQVKIETKISQTQQTQWLRDIINSFVKTQPNWNSQTESDTSAGEKDHLQGGALLYSNSDKTAYANSDYRLLNRTPTSQTGKPKYFEDNSSGGYDFLLANDIDNSNPVVQAEQLNWLHYLMNYGSIVANDPEANFDGVRVDAVDNVNADLLQIASDYLKAHYGVDKSEKNAINHLSILEAWSDNDPQYNKDTKGAQLPIDNKLRLSLLYALTRPLEKDASNKNEIRSGLEPVITNSLNNRSAEGKNSERMANYIFIRAHDSEVQTVIAKIIKAQINPKTDGLTFTLDELKQAFKIYNEDMRQAKKKYTQSNIPTAYALMLSNKDSITRLYYGDMYSDDGQYMATKSPYYDAIDTLLKARIKYAAGGQDMKITYVEGDKSHMDWDYTGVLTSVRYGTGANEATDQGSEATKTQGMAVITSNNPSLKLNQNDKVIVNMGTAHKNQEYRPLLLTTKDGLTSYTSDAAAKSLYRKTNDKGELVFDASDIQGYLNPQVSGYLAVWVPVGASDNQDVRVAASNKANATGQVYESSSALDSQLIYEGFSNFQDFVTKDSDYTNKKIAQNVQLFKSWGVTSFEMAPQYVSSEDGSFLDSIIQNGYAFEDRYDLAMSKNNKYGSQQDMINAVKALHKSGIQVIADWVPDQIYNLPGKEVVTATRVNDYGEYRKDSEIKNTLYAANTKSNGKDYQAKYGGAFLSELAAKYPSIFNRTQISNGKKIDPSEKITAWKAKYFNGTNILGRGVGYVLKDNASDKYFELKGNQTYLPKQMTNKEASTGFVNDGNGMTFYSTSGYQAKNSFVQDAKGNWYYFDNNGHMVYGLQHLNGEVQYFLSNGVQLRESFLENADGSKNYFGHLGNRYSNGYYSFDNDSKWRYFDASGVMAVGLKTINGNTQYFDQDGYQVKGAWITGSDGKKRYFDDGSGNMAVNRFANDKNGDWYYLNSDGIALVGVQTINGKTYYFGQDGKQIKGKIITDNGKLKYFLANSGELARNIFATDSQNNWYYFGSDGVAVTGSQTIAGKKLYFASDGKQVKGSFVTYNGKVHYYHADSGELQVNRFEADKDGNWYYLDSNGEALTGSQRINGQRVFFTREGKQVKGDVAYDERGLLRYYDKNSGNMVYNKVVTLANGRRIGIDRWGIARYY","868451","For other 'gtf' genes see SMu0914 (gtfB) and SMu0915 (gtfC).From Genbank:[gi:6166192]This enzyme is involved in the production of extracellular glucans that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris. ","glucosyltransferase-S","Extracellular","Matches in gapped BLAST to glucosyltransferase-S: residues 1-1462 are 95% similar to the previously sequenced protein in S.mutans (gi3130076).Residues 1-1459 are 57% and residues 998-1392 are 38% similar to this protein from S.gordonii (gi1054877).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0708 (5e-04).","

InterPro
IPR002479
Repeat

Putative cell wall binding repeat
PF01473	$\"[1117-1136]T$ $\"[1247-1266]T$ $\"[1311-1330]T$ $\"[1375-1394]T$	CW_binding_1
PS51170	$\"[171-190]T$ $\"[192-211]T$ $\"[1095-1115]T$ $\"[1116-1136]T$ $\"[1137-1156]T$ $\"[1180-1201]T$ $\"[1202-1221]T$ $\"[1223-1244]T$ $\"[1246-1266]T$ $\"[1267-1286]T$ $\"[1310-1330]T$ $\"[1331-1350]T$ $\"[1352-1372]T$ $\"[1374-1394]T$	CW

InterPro
IPR003318
Domain

Glycoside hydrolase, family 70, catalytic core
PF02324	$\"[281-1103]T$	Glyco_hydro_70

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[409-688]T$ $\"[878-963]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
G3DSA:2.10.270.10	$\"[1091-1201]T$ $\"[1202-1325]T$ $\"[1327-1454]T$	G3DSA:2.10.270.10
PTHR10357	$\"[937-963]T$	PTHR10357
PTHR10357:SF13	$\"[937-963]T$	PTHR10357:SF13
SSF51445	$\"[393-685]T$ $\"[861-1018]T$	SSF51445
SSF69360	$\"[173-221]T$ $\"[1323-1459]T$	SSF69360

","BeTs to 3 clades of COG0296COG name: 1,4-alpha-glucan branching enzymeFunctional Class: GThe phylogenetic pattern of COG0296 is ----yq-cebRh------in-Number of proteins in this genome belonging to this COG is 4","***** IPB003318 (Glucosyltransferase S precursor) with a combined E-value of 0. IPB003318A 1-19 IPB003318B 244-295 IPB003318C 319-362 IPB003318D 371-382 IPB003318E 416-464 IPB003318F 487-531 IPB003318G 575-619 IPB003318H 647-691 IPB003318I 711-741 IPB003318J 744-789 IPB003318K 804-847 IPB003318L 855-880 IPB003318M 902-921 IPB003318N 922-963 IPB003318O 964-990 IPB003318P 994-1038 IPB003318Q 1039-1069 IPB003318R 1255-1288","Residues 1364-1457 are 45% similar to a (TRANSFERASE SURFACE PSPC DEXTRANSUCRASE) protein domain (PD000439) which is seen in Q54178_STRGC.Residues 2-92 are 65% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002249) which is seen in GTFD_STRMU.Residues 1232-1315 are 36% similar to a (GLUCAN-BINDING GBP PRECURSOR REPEAT) protein domain (PD236206) which is seen in Q54447_STRMU.Residues 1204-1301 are 31% similar to a (DEXTRANSUCRASE GLYCOSYLTRANSFERASE) protein domain (PD174018) which is seen in Q9EZH5_LEUME.Residues 1313-1357 are 55% similar to a (TRANSFERASE SIGNAL 6-GLUCOSYLTRANSFERASE) protein domain (PD016627) which is seen in Q00599_STRSL.Residues 1111-1164 are 53% similar to a (TRANSFERASE PRECURSOR GLUCOSYLTRANSFERASE) protein domain (PD149701) which is seen in Q9ZAR4_LEUME.Residues 1413-1462 are 98% similar to a (CARIES GLYCOSYLTRANSFERASE) protein domain (PD248174) which is seen in GTFD_STRMU.Residues 1352-1412 are 47% similar to a (TRANSFERASE SIGNAL PRECURSOR) protein domain (PD285093) which is seen in GTFD_STRMU.Residues 1167-1237 are 43% similar to a (S CARIES GLYCOSYLTRANSFERASE PRECURSOR) protein domain (PD242668) which is seen in Q9WXJ5_BBBBB.Residues 1155-1250 are 41% similar to a (TRANSFERASE PRECURSOR GLUCOSYLTRANSFERASE) protein domain (PD203969) which is seen in Q55265_STRSL.Residues 968-1030 are identical to a (TRANSFERASE DEXTRANSUCRASE) protein domain (PD149672) which is seen in GTFD_STRMU.Residues 1157-1216 are 51% similar to a (TRANSFERASE GLUCOSYLTRANSFERASE-SI) protein domain (PD186762) which is seen in Q59983_BBBBB.Residues 1072-1131 are 45% similar to a (CARIES GLYCOSYLTRANSFERASE) protein domain (PD268663) which is seen in GTFB_STRMU.Residues 1032-1071 are identical to a (TRANSFERASE DEXTRANSUCRASE) protein domain (PD341788) which is seen in GTFD_STRMU.Residues 93-188 are 79% similar to a (CARIES GLYCOSYLTRANSFERASE) protein domain (PD282938) which is seen in GTFD_STRMU.Residues 859-967 are 78% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002312) which is seen in Q00599_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 13:25:37 2007","Wed Sep 27 14:16:07 2006","Thu Feb 3 14:53:28 2005","Thu Jan 3 09:47:30 2002","Thu Jan 3 09:47:30 2002","Thu Jan 3 09:47:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0827 is paralogously related (blast p-value < 1e-3) to SMu0914, a predicted glucosyltransferase-I; SMu0915,a predicted glucosyltransferase-SI; SMu1916,a predicted glucan-binding protein; SMu0700,a predicted BglB-like protein; SMu1843,a predicted levansucrase (fructosyltransferase) (beta-D-fructofuranosyl transferase); SMu1445,a predicted intracellular alpha-amylase; SMu0018,a predicted immunodominant glycoprotein IDG-60; general stress protein GSP-781; glucan binding protein B; SMu0999, SMu1947,a predicted surface protein; SMu0057,a predicted conserved hypothetical protein; SMu0631,a predicted hypothetical protein and SMu0070,a predicted fructan hydrolase; exo-beta-D-fructosidase.","Mon Feb 4 15:17:20 2002","","No significant hits to the NCBI PDB database.","SMU.910","","Residues 1127 to 1146 (E-value = 5.1e-07) place SMu0827 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1192 to 1211 (E-value = 3e-08) place SMu0827 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1257 to 1276 (E-value = 3.2e-08) place SMu0827 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1321 to 1340 (E-value = 4.3e-09) place SMu0827 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1385 to 1404 (E-value = 2e-08) place SMu0827 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)","Thu Feb 3 14:53:28 2005","24379358",""," Shemesh M, Tam A, Feldman M, Steinberg D.,Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases.Carbohydr Res. 2006 Sep 4;341(12):2090-7. Epub 2006 Jun 9.PMID: 16764842Tamesada M, Kawabata S, Fujiwara T, Hamada S.Synergistic effects of streptococcal glucosyltransferases on adhesive biofilm formation.J Dent Res. 2004 Nov;83(11):874-9.PMID: 15505239Chia JS, Lien HT, Hsueh PR, Chen PM, Sun A, Chen JY.Induction of cytokines by glucosyltransferases of streptococcus mutans.Clin Diagn Lab Immunol. 2002 Jul;9(4):892-7.PMID: 12093691Fujiwara,T., Terao,Y., Hoshino,T., Kawabata,S., Ooshima,T.,Sobue,S., Kimura,S. and Hamada,S.Molecular analyses of glucosyltransferase genes among strains ofStreptococcus mutansFEMS Microbiol. Lett. 161 (2), 331-336 (1998)PubMed: 9570124Honda,O., Kato,C. and Kuramitsu,H.K.Nucleotide sequence of the Streptococcus mutans gtfD gene encodingthe glucosyltransferase-S enzymeJ. Gen. Microbiol. 136 (Pt 10), 2099-2105 (1990)PubMed: 2148600Shiroza,T., Ueda,S. and Kuramitsu,H.K.Sequence analysis of the gtfB gene from Streptococcus mutansJ. Bacteriol. 169 (9), 4263-4270 (1987)PubMed: 3040685Ueda,S., Shiroza,T. and Kuramitsu,H.K.Sequence analysis of the gtfC gene from Streptococcus mutans GS-5Gene 69 (1), 101-109 (1988)PubMed: 2976010Banas JA, Russell RR, Ferretti JJSequence analysis of the gene for the glucan-binding protein of Streptococcus mutans Ingbritt.Infect Immun 1990 Mar;58(3):667-73PubMed: 2307516PMID: 2307516","Fujiwara,T., Hoshino,T., Ooshima,T., Sobue,S. and Hamada,S.Purification, characterization, and molecular analysis of the geneencoding glucosyltransferase from streptococcus oralisInfect. Immun. 68 (5), 2475-2483 (2000)PubMed: 10768934Simpson,C.L., Giffard,P.M. and Jacques,N.A.Streptococcus salivarius ATCC 25975 possesses at least two genescoding for primer-independent glucosyltransferasesInfect. Immun. 63 (2), 609-621 (1995)PubMed: 7822030Ferretti,J.J., Gilpin,M.L. and Russell,R.R.Nucleotide sequence of a glucosyltransferase gene fromStreptococcus sobrinus MFe28J. Bacteriol. 169 (9), 4271-4278 (1987)PubMed: 3040686Koo H, Seils J, Abranches J, Burne RA, Bowen WH, Quivey RG.Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.Antimicrob Agents Chemother. 2006 Feb;50(2):542-6.PMID: 16436708Chen PM, Chen JY, Chia JS.Differential regulation of Streptococcus mutans gtfBCD genes in response to copper ions.Arch Microbiol. 2006 Mar;185(2):127-35.PMID: 16395551","Tue Apr 24 13:01:03 2007","Tue Apr 24 13:25:37 2007","1","","","SMU.910","" "SMu0828","869136","868627","510","ATGAAATGGTTTACACTTATCTCAGGAGTTTTAACATTTTTAATCGGGATTTGGATTTTTGCTAATCCGCTTGTTGTCACTGCTTCAATTGGTTGGCTGCTAGCGTTAATTATTTTTTTAGTTGGTATTACAGGATTTATTGATTATATGTCTAAATCGCGTGAAGAAAGAACCATCTGGAATCTTTTACAAAGTATCGTTTCTATCATTTTTGGATTCATCCTTCTAACGTCTTCCATCTTTTCTTTAACCACGGCGGTTGTTACCATTGCTGCTTACTGGATTATTTTAATCGGTATTCTAAGACTTATTTCCGGCTATCGTTTGCGTCAGATGGGCTTTCCACAAAGTAATCGGTTCTTTTGGACGGGTAGTTTTGCGCTTTTATTGGGACTCATTCTATTAGGTCAGCCTCTTCTTTCTTCAGCCATTATCGGTCGGTTTGTGGCTCTTCTTTTAATGGCAACAGGTATTTCCAGCTTCCTTGTTTTTTTGCGTTTACTGGAATAA","11.60","5.98","18853","MKWFTLISGVLTFLIGIWIFANPLVVTASIGWLLALIIFLVGITGFIDYMSKSREERTIWNLLQSIVSIIFGFILLTSSIFSLTTAVVTIAAYWIILIGILRLISGYRLRQMGFPQSNRFFWTGSFALLLGLILLGQPLLSSAIIGRFVALLLMATGISSFLVFLRLLE","868632","","hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical protein (gtfD 3' region): residues 1-169 are 81% similar to a previously published protein in S.mutans (gi|97991|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1336 (4e-31).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-45]?$	signal-peptide
tmhmm	$\"[2-22]?$ $\"[28-50]?$ $\"[59-81]?$ $\"[87-107]?$ $\"[122-142]?$ $\"[148-168]?$	transmembrane_regions

InterPro
IPR006095
Family

Glu/Leu/Phe/Val dehydrogenase
PR00082	$\"[115-129]T$ $\"[194-216]T$ $\"[236-256]T$ $\"[373-384]T$	GLFDHDRGNASE
PTHR11606:SF2	$\"[21-449]T$	GLFV_DH

InterPro
IPR006096
Domain

Glu/Leu/Phe/Val dehydrogenase, C-terminal
PF00208	$\"[203-447]T$	ELFV_dehydrog

InterPro
IPR006097
Domain

Glu/Leu/Phe/Val dehydrogenase, dimerisation region
PF02812	$\"[58-188]T$	ELFV_dehydrog_N

InterPro
IPR014362
Family

Glutamate dehydrogenase
PIRSF000185	$\"[20-449]T$	Glu_DH

noIPR
unintegrated

unintegrated
G3DSA:1.10.285.10	$\"[5-55]T$	G3DSA:1.10.285.10
G3DSA:3.40.192.10	$\"[60-202]T$	G3DSA:3.40.192.10
G3DSA:3.40.50.720	$\"[203-447]T$	G3DSA:3.40.50.720
PTHR11606	$\"[21-449]T$	PTHR11606
SSF51735	$\"[198-449]T$	SSF51735
SSF53223	$\"[5-197]T$	SSF53223

","BeTs to 8 clades of COG0334COG name: Glutamate dehydrogenase/leucine dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0334 is a--kY-vceBrhuj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB001625 (Glutamate/leucine/phenylalanine/valine dehydrogenase) with a combined E-value of 5.9e-109. IPB001625A 80-100 IPB001625B 110-146 IPB001625C 159-184 IPB001625D 195-215 IPB001625E 233-260 IPB001625F 344-356 IPB001625G 364-388","Residues 70-103 are 88% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE NADP) protein domain (PD000880) which is seen in DHE4_UNKP.Residues 189-294 are 65% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE NADP) protein domain (PD000883) which is seen in DHE4_HELPY.Residues 26-69 are 63% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE) protein domain (PD345316) which is seen in O87403_BACLI.Residues 317-379 are 69% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE NADP-SPECIFIC) protein domain (PD403279) which is seen in Q9K580_KLEPN.Residues 352-449 are 45% similar to a (NADP-GDH NADP-SPECIFIC DEHYDROGENASE) protein domain (PD244467) which is seen in DHE4_CORGL.Residues 380-443 are 75% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE NADP) protein domain (PD186465) which is seen in Q9KB34_BACHD.Residues 314-378 are 70% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE GDH NAD NADP) protein domain (PD397047) which is seen in Q9CPJ4_PASMU.Residues 145-187 are 90% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE) protein domain (PD328719) which is seen in DHE4_GIALA.Residues 105-144 are 92% similar to a (DEHYDROGENASE GLUTAMATE OXIDOREDUCTASE NADP-SPECIFIC) protein domain (PD328957) which is seen in Q9KB34_BACHD.Residues 24-68 are 57% similar to a (DEHYDROGENASE GLUTAMATE NADP-SPECIFIC) protein domain (PD356884) which is seen in DHE4_GIALA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 12:49:39 2002","Thu Jan 3 10:06:34 2002","Sat Oct 12 12:49:39 2002","Thu Jan 3 10:06:34 2002","Thu Jan 3 10:06:34 2002","Thu Jan 3 10:06:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0829 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 10:07:45 2002","Thu Jan 3 10:06:34 2002","pdb|1BGV|A Chain A, Glutamate Dehydrogenase >gi|1942184|pdb|1HR... 483 1e-137pdb|1K89| K89l Mutant Of Glutamate Dehydrogenase 480 2e-136pdb|1AUP| Glutamate Dehydrogenase 478 5e-136","SMU.913","","Residues 58 to 188 (E-value = 1.8e-77) place SMu0829 in the GLFV_dehydrog_N family which is described as Glu/Leu/Phe/Val dehydrogenase, dimerisation domain (PF02812)Residues 203 to 447 (E-value = 1.4e-126) place SMu0829 in the GLFV_dehydrog family which is described as Glutamate/Leucine/Phenylalanine/Valine dehydrogenase (PF00208)","Thu Jan 3 10:06:34 2002","24379360","","","Bormann,E.R., Eikmanns,B.J. and Sahm,H.Molecular analysis of the Corynebacterium glutamicum gdh geneencoding glutamate dehydrogenaseMol. Microbiol. 6 (3), 317-326 (1992)PubMed: 1552846Okwumabua,O., Persaud,J.S. and Reddy,P.G.Cloning and Characterization of the Gene Encoding the GlutamateDehydrogenase of Streptococcus suis Serotype 2Clin. Diagn. Lab. Immunol. 8 (2), 251-257 (2001)PubMed: 11238204","","Thu Jan 3 10:10:04 2002","1","","","SMU.913","141" "SMu0830","871616","871233","384","ATGATGAAAAATGAATTGAAAACTTTTCTTAAACCAACTCTTCGTAGAGTGATTGTTATCCTAAGTATCACCTTGCTGCTGTCGGCTTTCTTATACTGGGGACAAAGGGATCGCTTTAATGCCAGAAATGTTTTATGTACTGGAATAATCATTACCGCAATTGCTGGCGCTTGGAATATCTACGATCTTAACTCTCTGTCTCTCATTAAGCGCAGTCTTATTCATTTTTTATTAATGGCCATTACTATTTTACCCACACTTCTATTAAGCGGCTGGTTCCCAATAAAAACTTTCGGTGACATCGTTTTAATGATTGCTATCTTTTTGTTCAGCGGTCTGCTTTGCTGGACAATCGGATACCTTGCTTTTCGAAATAAAAAATAA","11.10","10.12","14521","MMKNELKTFLKPTLRRVIVILSITLLLSAFLYWGQRDRFNARNVLCTGIIITAIAGAWNIYDLNSLSLIKRSLIHFLLMAITILPTLLLSGWFPIKTFGDIVLMIAIFLFSGLLCWTIGYLAFRNKK","871238","","conserved hypothetical protein","Membrane, Cytoplasm","Only one hit in gapped BLAST to an unknown protein:residues 60-123 are 42% similar in S.aureus (gi|6690328|)SMu0830 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-28]?$	signal-peptide
tmhmm	$\"[12-32]?$ $\"[38-58]?$ $\"[73-93]?$ $\"[103-123]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 60-123 are 42% similar to a (PLASMID) protein domain (PD293529) which is seen in Q9RGP0_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 15:41:14 2002","Thu Jan 3 10:13:33 2002","Wed Mar 20 15:41:14 2002","Thu Jan 3 10:13:33 2002","","Thu Jan 3 10:13:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0830 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 14:23:24 2002","","No significant hits to the NCBI PDB database.","SMU.914c","","No significant hits to the Pfam 11.0 database","Thu Jan 3 10:13:33 2002","24379361","","","","","","1","","","SMU.914c","" "SMu0831","872213","871725","489","ATGTCACAAGAAGAAATAAAAGACTTAACTCTTTTGGGAAATCAAAAGACCAATTACAACTTTGATTATGATCTCAATATTTTGGAAGCTTTCGATAATCGCCATCAAGATAACGATTATTTTATCAAGTTTAACTGTCCAGAATTTACCTCTCTGTGTCCTATAACGGGGCAGCCTGATTTTGCAACTATCTATCTCTCTTATATTCCAGATAAAAAATGCGTTGAATCCAAATCACTCAAACTTTATCTCTTTAGTTACCGTAACCATGGTGATTTTCATGAGAATTGTATCAATACGATTGGTAAAGATCTCGTCGATCTATTACAGCCTCGTTATCTAGAAGTCTGGGGCAAATTTACACCGCGTGGCGGTATCTCTATTGATCCTTATTATAATTACGGACGCCCAAATACCAAATATGAAGAAATGGCAGCTTATCGTTTGATGAACCACGATCTTTACCCAGAAACAATTGATAATCGTTAA","4.90","-6.23","19155","MSQEEIKDLTLLGNQKTNYNFDYDLNILEAFDNRHQDNDYFIKFNCPEFTSLCPITGQPDFATIYLSYIPDKKCVESKSLKLYLFSYRNHGDFHENCINTIGKDLVDLLQPRYLEVWGKFTPRGGISIDPYYNYGRPNTKYEEMAAYRLMNHDLYPETIDNR","871730","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical protein: residues 3-162 are 76% similar to S.aureus (gi|15923718|) and 74% similar to B.halodurans (gi|15614804|).SMu0831 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001474
Family

GTP cyclohydrolase I
PF01227	$\"[40-139]T$	GTP_cyclohydroI

noIPR
unintegrated

unintegrated
SSF55620	$\"[26-157]T$	SSF55620

","BeTs to 7 clades of COG0780COG name: Uncharacterized BCR, YkvM familyFunctional Class: SThe phylogenetic pattern of COG0780 is -----qvceb-Huj------xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 28-118 are 75% similar to a (COMPLETE PROTEOME I BH2241) protein domain (PD010789) which is seen in O31678_BACSU.Residues 119-153 are 85% similar to a (PROTEOME COMPLETE BH2241 NMA2170) protein domain (PD329959) which is seen in Q9KAP6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 14:23:46 2002","Thu Jan 3 11:20:40 2002","Fri Jan 25 14:23:46 2002","Thu Jan 3 11:20:40 2002","","Thu Jan 3 11:20:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0831 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 14:23:46 2002","","No significant hits to the NCBI PDB database.","SMU.915c","","Residues 40 to 139 (E-value = 1.7e-56) place SMu0831 in the GTP_cyclohydroI family which is described as GTP cyclohydrolase I (PF01227)","Thu Jan 3 11:20:40 2002","24379362","","","","","","1","","","SMU.915c","" "SMu0832","872957","872226","732","ATGGGATTTACAAGCATGAAAAAACAACGTCTGTTAAAGTTACCCGTTTTAGAAATCTTTGGTCCAACTTTTCAAGGAGAAGGCAGGGCCATCGGTCAAAAAACTATGTTTGTTCGTACAGGTGGCTGTGATTATCACTGCGATTGGTGCGATTCTGCCTTTACTTGGGACGGTTCTGAAAAGCCAACTATGATGACCAGTGACCAAATTATTGAAGCATTAGATAAACTTGGTACTTATGATTATGTGACACTCTCTGGCGGCAATCCTTGCCTTCTGGCTGCTAATATGGCCCAGCTCGTTAGGAAACTCAAAAAAAGACAAGTCACTCTTGCTGTCGAAACTCAAGGTTCTCGCTGGCAAGAATGGCTAAAAGCCATTGATCAAGTAACTTTAAGCCCTAAACCGCCGTCCAGCAAAATGAAAGTAAACTTACAAACCCTTGATTTTATCGTATCAAATTTAGATCCACAAAAGGTAACTTACAAAATCCCTATCTTTGACGAAGACGATTTAAAATTCGCCCAAATGATCCAAGGACGCTATCAGCCAGATGTCCTTTATCTGTCTGTTGGAAATCCAGAGCCCAAAGCCAGTGGTGATATTGTCCAAAATCAGCTGAAACGTTTAAAAGAGTTATGGGAACACATTGCTCAAGATGATTCTTGGGGAAATGTCCGCGTCTTACCGCAATTGCATACACTTGTTTATGATAATAAACGTGGTGTCTAG","8.20","2.53","27557","MGFTSMKKQRLLKLPVLEIFGPTFQGEGRAIGQKTMFVRTGGCDYHCDWCDSAFTWDGSEKPTMMTSDQIIEALDKLGTYDYVTLSGGNPCLLAANMAQLVRKLKKRQVTLAVETQGSRWQEWLKAIDQVTLSPKPPSSKMKVNLQTLDFIVSNLDPQKVTYKIPIFDEDDLKFAQMIQGRYQPDVLYLSVGNPEPKASGDIVQNQLKRLKELWEHIAQDDSWGNVRVLPQLHTLVYDNKRGV","872231","","conserved hypothetical protein","Cytoplasm, Periplasm","Limited matches in gapped BLAST to conserved hypothetical protein and to coenzyme PQQ synthesis homologue: residues 13-243 are 47% similar to conserved hypothetical protein in B.halodurans (gi|15614805|) and residues 11-243 are also 47% similar to coenzyme PQQ synthesis homologue in S.aureus.SMu0832 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[37-178]T$	Radical_SAM

noIPR
unintegrated

unintegrated
SSF102114	$\"[22-141]T$	SSF102114

","BeTs to 10 clades of COG0602COG name: Organic radical activating enzymesFunctional Class: OThe phylogenetic pattern of COG0602 is amTK-q-cEB-Huj------xNumber of proteins in this genome belonging to this COG is 2","***** IPB001989 (Radical activating enzymes) with a combined E-value of 1.9e-13. IPB001989A 29-56 IPB001989B 82-93","Residues 13-71 are 76% similar to a (COMPLETE PROTEOME COENZYME III) protein domain (PD011038) which is seen in Q9KAP5_BACHD.Residues 74-133 are 41% similar to a (COMPLETE PROTEOME COFACTOR BIOSYNTHESIS MOLYBDENUM) protein domain (PD000790) which is seen in Q9KAP5_BACHD.Residues 134-243 are 42% similar to a (PROTEOME COMPLETE BH2242 EXSD) protein domain (PD034449) which is seen in O31677_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 15:44:41 2002","Thu Jan 3 11:23:07 2002","Wed Mar 20 15:44:41 2002","Thu Jan 3 11:23:07 2002","Thu Jan 3 11:23:07 2002","Thu Jan 3 11:23:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0832 is paralogously related (blast p-value < 1e-3) to SMu1879, a predicted anaerobic ribonucleoside-triphosphate reductase activating protein (NrdD activating enzyme,generating glycyl radical).","Fri Jan 25 14:25:06 2002","","No significant hits to the NCBI PDB database.","SMU.916c","","Residues 37 to 178 (E-value = 2.3e-06) place SMu0832 in the Radical_SAM family which is described as Radical SAM superfamily (PF04055)","Thu Jan 3 11:23:07 2002","24379363","","","","","","1","","","SMU.916c","" "SMu0833","873385","872939","447","ATGTTCTTAGCGCCAAAAGAAATTAAAAACGAGACAGGAGAATCACTTCTTTATTGTCCCAAACGCGTTCTTGTATCTAAAGAATTCACCTTTAATGCTGCCCACCATCTCTTCAATTATGAAGGGAAATGCAAAGCCTTACATGGACATACTTATCATTTACAAGTTGCTGTCAGTGCTTTTCTTGATGAACGCGGAATGACTTATGATTTTAGAGAGTTGAAAAGGATCTACCAAGAATATTTAGAACCAAAACTAGACCACCGCTACCTTAATGAAAGTCTGCCCTACATGAATACAACTGCTGAAAATATGGTTTATTGGATTTACAAAACAGTCGAGAAAGCTTTAACTGACGAGCGCGGTTTACAAATGGAACATGTTCGCCTTTATGAAACACCCTCAGCTTATGCTGAATTTAGAAGAGAATGGGATTTACAAGCATGA","6.60","-1.41","17695","MFLAPKEIKNETGESLLYCPKRVLVSKEFTFNAAHHLFNYEGKCKALHGHTYHLQVAVSAFLDERGMTYDFRELKRIYQEYLEPKLDHRYLNESLPYMNTTAENMVYWIYKTVEKALTDERGLQMEHVRLYETPSAYAEFRREWDLQA","872944","","6-pyruvoyl tetrahydropterin synthase, PTPS","Cytoplasm","Several matches in gapped BLAST to 6-pyruvoyl tetrahydrobiopterin synthase: residues 23-143 are 39% similar to the enzyme in Thermotoga maritima (gi|15642813|). Residues 25-141 are 31% similar to the protein from Haemophilus influenzae Rd (gi|16273112|).SMu0833 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007115
Family

6-pyruvoyl tetrahydropterin synthase and hypothetical protein
PD004049	$\"[27-59]T$	PTPS_hypoth
PIRSF006113	$\"[22-143]T$	PTP_syn
PTHR12589	$\"[1-144]T$	6_PTP_synth
PF01242	$\"[20-143]T$	PTPS

noIPR
unintegrated

unintegrated
G3DSA:3.30.479.10	$\"[17-143]T$	G3DSA:3.30.479.10
SSF55620	$\"[19-143]T$	SSF55620

","BeTs to 11 clades of COG0720COG name: 6-pyruvoyl-tetrahydropterin synthaseFunctional Class: HThe phylogenetic pattern of COG0720 is amtK-Qvceb-huj------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001914 (6-pyruvoyl tetrahydropterin synthase) with a combined E-value of 3.7e-18. IPB001914A 30-39 IPB001914B 42-56 IPB001914C 101-111 IPB001914D 125-142","Residues 28-136 are 41% similar to a (SYNTHASE TETRAHYDROBIOPTERIN PROTEOME) protein domain (PD004049) which is seen in Q9WXP5_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 15:51:35 2002","Sat Oct 12 12:59:40 2002","Sat Oct 12 12:59:40 2002","Thu Jan 3 11:24:14 2002","Thu Jan 3 11:24:14 2002","Thu Jan 3 11:24:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0833 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 11:26:11 2002","","No significant hits to the NCBI PDB database.","SMU.917c","","Residues 20 to 143 (E-value = 3.7e-08) place SMu0833 in the PTPS family which is described as 6-pyruvoyl tetrahydropterin synthase (PF01242)","Thu Jan 3 11:24:14 2002","24379364","","","Thony B, Auerbach G, Blau N.Tetrahydrobiopterin biosynthesis, regeneration and functions.Biochem J. 2000 Apr 1;347 Pt 1:1-16. Review.PMID: 10727395","","Sat Oct 12 12:59:40 2002","1","","","SMU.917c","" "SMu0834","874038","873385","654","ATGAAACGTCAATCAGCTCTTGTCGTCTTTAGCGGTGGTCAAGATTCAACTACCTGCCTTTTTTGGGCAATGAAGCATTATGAATATGTCGAAACAGTTACCTTTTCCTATGGCCAACGTCACAGTCAAGAATTAGAGGTTGCCAAGGAAATTGCTGCAGAACAAGGCGTGAAACACCATATCCTTGATATGTCTTTACTGGGACAAATAACAGAAAATGCCTTAACTTCTGACATAGCTATAGAAACAAAAGACGGTGAAGTCCCCAATACTTTTGTTGATGGCAGAAATCATCTCTTTCTTTCCTTTGCTGCAGTCCTTGCCAAACAGCGCAAGATAAGAGATATTGTCACCGGAGTCTGTCAAACAGATTTTTCAGGTTATCCTGACTGTCGTGATGTTTTTGTCAAGTCTCTCAATGTTACCTTAAATCTTGCTATGGATTATGAATTCGTCATTCAAACGCCTCTGATGTGGCTAGACAAGGCCGAAACATGGGAATTGGCAGATCAGCTAGGTAAATTTGATTATGTTCGTCAAAAGACTCTGACCTGCTACAATGGAATTCGAGGAACTGGCTGCAGACAATGCCCTGCCTGCCATTTACGTCAAGCTGGACTTGAAAAATATCTTAGTCAGAAAGGAAAAAATTAA","6.80","-0.89","24530","MKRQSALVVFSGGQDSTTCLFWAMKHYEYVETVTFSYGQRHSQELEVAKEIAAEQGVKHHILDMSLLGQITENALTSDIAIETKDGEVPNTFVDGRNHLFLSFAAVLAKQRKIRDIVTGVCQTDFSGYPDCRDVFVKSLNVTLNLAMDYEFVIQTPLMWLDKAETWELADQLGKFDYVRQKTLTCYNGIRGTGCRQCPACHLRQAGLEKYLSQKGKN","873390","","ATPase, confers aluminum resistance","Cytoplasm","Limited matches in gapped BLAST to aluminum resistance protein and to conserved hypotheticals: residues 2-214 are 68% similar to the aluminum resistance protein in B.halodurans (gi|15614807|). Residues 1-216 are 68% similar to the hypothetical proteins in B.subtilis (gi|16078436|)SMu0834 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004479
Family

ExsB
PIRSF006293	$\"[4-217]T$	ExsB
PF06508	$\"[5-173]T$	ExsB
TIGR00364	$\"[6-203]T$	ExsB

noIPR
unintegrated

unintegrated
SSF52402	$\"[1-182]T$	SSF52402

","BeTs to 10 clades of COG0603COG name: Predicted ATPase (PP-loop superfamily), confers aluminum resistanceFunctional Class: RThe phylogenetic pattern of COG0603 is amtk-Q-ceb-huj------xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-95 are 69% similar to a (PROTEOME COMPLETE EXSB REGULATOR) protein domain (PD342521) which is seen in O31675_BACSU.Residues 96-138 are 76% similar to a (PROTEOME COMPLETE EXSB REGULATOR) protein domain (PD005627) which is seen in Q9KAP3_BACHD.Residues 172-214 are 67% similar to a (PROTEOME COMPLETE ALUMINUM RESISTANCE) protein domain (PD283345) which is seen in Q9KAP3_BACHD.Residues 139-171 are 84% similar to a (PROTEOME COMPLETE ALUMINUM RESISTANCE) protein domain (PD323927) which is seen in Q9KAP3_BACHD.Residues 96-207 are 60% similar to a (PROTEOME HUPB-COF COMPLETE) protein domain (PD355184) which is seen in YBAX_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 20 15:53:58 2002","Fri Jan 25 14:26:13 2002","Sat Oct 12 13:04:10 2002","Thu Jan 3 11:36:02 2002","","Thu Jan 3 11:36:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0834 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 11:38:17 2002","","No significant hits to the NCBI PDB database.","SMU.919c","","Residues 70 to 139 (E-value = 3.1e-39) place SMu0834 in the ExsB family which is described as ExsB (PF06508)","Thu Jan 3 11:36:02 2002","24379365","","","Jo,J., Jang,Y.S., Kim,K.Y., Kim,M.H., Kim,I.J. and Chung,W.I.Isolation of ALU1-P gene encoding a protein with aluminum tolerance activity from Arthrobacter viscosusBiochem. Biophys. Res. Commun. 239 (3), 835-839 (1997)PubMed: 9367855","","Thu Jan 3 11:38:17 2002","1","","","SMU.919c","" "SMu0835","874590","875024","435","ATGAAGGAGCCTTTTAGTGAATTTAAAAACCTCATTACAGCAACAGAAAGATATATTCAAGAATTATCCAAAAGCCATGGTGTTGAACATCTGTCCGGACCTCAGGGATGGACAGTTATGTTTTTAAAGGATAATCAAGGAAAGGAAATTTTTATTAAAGATATTGAAAAAAGGTTAGATATCTCAAAATCTGTGACCAGTAATCTCATTAAACGAATGGAAAAAAATGGTTTTATTTCTGTTATTCCTTCCAGAAAAGACAGACGATACAAGCAAATTGTTTTAACGCCATTAGGTCAGGAAAAAGCTGGAAAAATAACTGTTTTTTTAACAGATCTTAAAAAGTTGCTTCTAAAAGATATTAGTCAGGAAGACTTATCAGTTGCTCGGAAGGTTTTTAAACAAATCAAACAAAATTTAGAAAAGAAGGAGTAA","10.60","10.48","16704","MKEPFSEFKNLITATERYIQELSKSHGVEHLSGPQGWTVMFLKDNQGKEIFIKDIEKRLDISKSVTSNLIKRMEKNGFISVIPSRKDRRYKQIVLTPLGQEKAGKITVFLTDLKKLLLKDISQEDLSVARKVFKQIKQNLEKKE","875023","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator: residues 1-137 are 33% similar to the protein in S.pneumoniae (gi|15901744|). Residues 9-106 are 31% similar to the protein from Clostridium acetobutylicum (gi|15896654|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1332 (8e-30).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PR00598	$\"[67-82]T$ $\"[86-102]T$ $\"[116-136]T$	HTHMARR
PF01047	$\"[52-102]T$	MarR
SM00347	$\"[24-126]T$	HTH_MARR
PS01117	$\"[64-99]?$	HTH_MARR_1
PS50995	$\"[1-138]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-113]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[10-143]T$	SSF46785

","BeTs to 3 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class: KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","***** IPB000835 (Bacterial regulatory protein, MarR family) with a combined E-value of 4.4e-09. IPB000835 66-99","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 15:26:33 2002","Thu Jan 3 11:41:58 2002","Sat Oct 12 13:05:03 2002","Thu Jan 3 11:40:47 2002","Thu Jan 3 11:40:47 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0835 is paralogously related (blast p-value < 1e-3) to SMu1004, and SMu1787, both predicted transcriptional regulators.","Fri Jan 25 15:26:22 2002","","No significant hits to the NCBI PDB database.","SMU.921","","Residues 31 to 136 (E-value = 9.4e-10) place SMu0835 in the MarR family which is described as MarR family (PF01047)","Thu Jan 3 11:40:47 2002","24379366","","","","","","1","","","SMU.921","939" "SMu0836","875028","876830","1803","ATGTTTAAAATTTTTAAACGTCTAAATGCTAAAGAATGGGGCATGGTTCTCCTTAGTACTGCCTTTATCTGTTTGGCTGTCTGGATGGATTTGAAGACGCCCGAATATATGTCCAACATTACAACCTTGCTGCAGACTAAGGGAACGACCGCCTCAGATATTATGGATCCGGGATCTAAGATGCTCATGTTTTCATTTGGGAGCTTTTTTATGGCCGTTCTAGTTGGTTTTTTAGCTTCAAGAACAGCTGCTAGCTTTACGACCCGTCTTCGATCTGATATTTTCAATCGGGTTATGGATTATTCAGAGGCGGAAATCAAGAAATTTTCCATTCCCAGCCTTCTAACGCGTACGACTAATGATTTGACACAGTTGCAAATCATGATCGTTATGGGAATGCAAGTGGTGACACGCGGTCCAATCATGGCTGTTTGGGCCTTGACTAAAATCTGGGGTAAAAGCGATGAATGGACAGGAGCAGTCGGTGTTGCCGTTTTAATTGTCTTTATTATGCTGTCTGTTTTGATGTTTGTCGCTTTTCCAAGACAGCGTCAGGTGCAGAGCTTGACGGATGCTCTAAATTCTACAACCCGTGAATCTCTGACTGGTGTTCGTGTTGTTCGGGCTTACAATGCAGAAGATTATCAGGACACTAAATTTAAGCGGGAAAATAAAAACCTGACGAAATTGAATTTATTGGTCTATCGTCTGATGTCGCTAATGAATCCTGTCATGACAGTTGTTTCCAGTGGTCTAACTTTAGCTATTTATTGGATTGGAGCTTACCTGCTCAATGATATTAAAATTCCTATGACGAGTGTGACAGCTGCTAAAGGAGCTATTGCTGATCGTATCAGTGTTTTTAGTGATATGGTTGTCTTTTCATCTTATGCCATGCAGGTTGTTGTCGGTTTTATGATGATGGTCGCTATCTTTATCATTTTACCGCGTGCTTTAGTTTCTGCCAAACGAATTAATGAAGTATTGGCGCTTAACTCATCTGTACACTTCAAAGAATATTCTAAAGCAGACAATGCTCGAAAAGGAGAAGTCGAATTTCATGATGTATCGTTTCGTTACAGTAAAAATTCTCGTGCGGTTATTGAGCATGTGTCTTTCAGTGCTAAAGCTGGTGAGACAGTTGCTTTTATTGGTTCCACTGGCTCAGGAAAATCAACTCTTGTTAATCTGATTCCTCGTTTTTATGATGCTACAGAAGGTTGGATTAAGATAGATGGAATCAAAGTGCAAGATTACAGCCATGATGACCTCAACAATAAAGTCGGCTATATTCCGCAAAGGGCAGTGCTTTTTAGTGGGACCATTCGTTCTAATATTGCATTTGGGCAAAGCGATCAAGCGCCGCTTGATGATGCTAAAATTTGGGAGGCTCTTGAACTAGCCCAAGCCAAAAACTTTGTTGAAGAAAAAGAAAAGGGTCTGGATACCGAGGTAGCTCAAGGCGGTACCAACTTCTCTGGCGGTCAAAAGCAGCGCTTAGCTATTGCCCGTGCACTTGCACGCAAACCAGAAATTCTTATTTTTGATGACTCCTTCTCAGCTCTTGATTATAAGACGGATCGCATTCTGCGAAATGATTTGGCAAAGAAAACCAAAGAAATGACTAAGTTGATTGTAGCCCAACGTATTTCAACTATTATGGATGCTGATCATATTTTGGTCTTAGATCAGGGAAAGGTTGTTGGTCAAGGAACACACAAGGAATTACTGGCTAATAACGATATTTATCAAGAAATTGCTTATTCACAACTATCTAAGGAGGAGTTAGAAAATGGAAAATAA","10.00","10.44","66961","MFKIFKRLNAKEWGMVLLSTAFICLAVWMDLKTPEYMSNITTLLQTKGTTASDIMDPGSKMLMFSFGSFFMAVLVGFLASRTAASFTTRLRSDIFNRVMDYSEAEIKKFSIPSLLTRTTNDLTQLQIMIVMGMQVVTRGPIMAVWALTKIWGKSDEWTGAVGVAVLIVFIMLSVLMFVAFPRQRQVQSLTDALNSTTRESLTGVRVVRAYNAEDYQDTKFKRENKNLTKLNLLVYRLMSLMNPVMTVVSSGLTLAIYWIGAYLLNDIKIPMTSVTAAKGAIADRISVFSDMVVFSSYAMQVVVGFMMMVAIFIILPRALVSAKRINEVLALNSSVHFKEYSKADNARKGEVEFHDVSFRYSKNSRAVIEHVSFSAKAGETVAFIGSTGSGKSTLVNLIPRFYDATEGWIKIDGIKVQDYSHDDLNNKVGYIPQRAVLFSGTIRSNIAFGQSDQAPLDDAKIWEALELAQAKNFVEEKEKGLDTEVAQGGTNFSGGQKQRLAIARALARKPEILIFDDSFSALDYKTDRILRNDLAKKTKEMTKLIVAQRISTIMDADHILVLDQGKVVGQGTHKELLANNDIYQEIAYSQLSKEELENGK","876829","For other components see SMu0836 (NBD1); SMu0837 (NBD2) and SMu0837 (MSD2).","ABC-type multidrug / protein/ lipid transport system, ATPase component","Membrane, Cytoplasm","Several matches in gapped BLAST to ABC-type multidrug / protein/ lipid transport system, ATPase component: residues 1-596 are 41% similar to the protein in Clostridium acetobutylicum (gi|15896527|). Residues 31-596 are 43% similar to the protein from Listeria monocytogenes (gi|16802649|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1338 (1e-109).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[16-277]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[491-532]T$	ABC_transporter
PF00005	$\"[378-565]T$	ABC_tran
PS00211	$\"[492-506]T$	ABC_TRANSPORTER_1
PS50893	$\"[351-589]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[377-566]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[17-317]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[316-598]T$	G3DSA:3.40.50.300
PTHR19242	$\"[1-266]T$ $\"[283-599]T$	PTHR19242
PTHR19242:SF91	$\"[1-266]T$ $\"[283-599]T$	PTHR19242:SF91
SSF52540	$\"[351-594]T$	SSF52540
SSF90123	$\"[5-327]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.8e-63. IPB001140A 367-413 IPB001140B 489-527 IPB001140C 542-571","Residues 332-506 are 25% similar to a (ABC TRANSPORTER) protein domain (PD241124) which is seen in Q9U0N4_PLAF7.Residues 163-264 are 32% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD200980) which is seen in Q9CIU5_LACLA.Residues 184-260 are 38% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD200991) which is seen in YC73_MYCTU.Residues 90-144 are 43% similar to a (ATP-BINDING PROTEOME COMPONENT COMPLETE) protein domain (PD412583) which is seen in Q9L4X5_BBBBB.Residues 542-593 are 55% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD394504) which is seen in Q9ZIC8_LISMO.Residues 78-144 are 41% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD384480) which is seen in Q9EW98_BBBBB.Residues 431-489 are 42% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD054667) which is seen in Q9CC88_MYCLE.Residues 544-590 are 51% similar to a (ATP-BINDING ABC TRANSPORTER TRANSMEMBRANE) protein domain (PD405975) which is seen in YC73_MYCTU.Residues 290-360 are 39% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in Q9L2F3_STRCO.Residues 433-489 are 52% similar to a (ATP-BINDING TRANSPORT TRANSMEMBRANE GLYCOPROTEIN) protein domain (PD000101) which is seen in Q9CIU5_LACLA.Residues 368-418 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9KDT5_BACHD.Residues 491-534 are 70% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9L2F3_STRCO.Residues 433-487 are 47% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD387938) which is seen in Q9PR86_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:00:15 2002","Mon Oct 28 13:00:15 2002","Mon Oct 28 13:00:15 2002","Thu Jan 3 11:43:18 2002","Thu Jan 3 11:43:18 2002","Thu Jan 3 11:43:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0836 is paralogously related (blast p-value < 1e-3) to SMu0824, SMu0987, SMu0825, SMu0476, SMu0475, SMu0986, SMu1710, SMu0837, SMu0258, SMu1064, SMu1065, SMu1724, SMu0024, SMu1950, SMu1920, SMu1246, SMu1231, SMu0517, SMu1762, SMu1003, SMu0731, SMu1949, SMu0884, SMu1068, SMu1757, SMu0971, SMu0235, SMu0418, SMu1545, SMu1288, SMu0218, SMu1751, SMu0805, SMu0916, SMu0849, SMu0786, SMu1036, SMu0390, SMu0907, SMu1518, SMu1428, SMu1037, SMu0944, SMu1517, SMu0594, SMu0374, SMu1210, SMu0335, SMu0950, SMu0596, SMu1380, SMu1079, SMu1023, SMu1316, SMu0234, SMu1093, SMu0216, SMu0224, SMu1649, SMu0976, SMu0729, SMu0752, SMu1410, SMu0164, SMu1001, SMu1811, SMu1959, SMu0823, SMu0666, SMu1306, SMu1050, SMu1686, and SMu1725 all with ATP-binding capabilities.","Thu Mar 21 08:16:32 2002","Thu Jan 3 11:43:18 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 83 6e-017pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 68 4e-012","SMU.922","","Residues 16 to 286 (E-value = 1.3e-10) place SMu0836 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 378 to 565 (E-value = 4.1e-46) place SMu0836 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Jan 3 11:43:18 2002","24379367","","Qi,F., Chen,P. and Caufield,P.W.Purification of mutacin III from group III streptococcus mutansUA787 and genetic analyses of mutacin III biosynthesis genesAppl. Environ. Microbiol. 65 (9), 3880-3887 (1999)PubMed: 10473390Pubmed:10473390","","Wed Mar 27 10:51:58 2002","","1","","","SMU.922","" "SMu0837","876820","878574","1755","ATGGAAAATAAGAAGAAATCATTATTAAGCCAAATGGCTCCTTACCTTAAAGGCTATAAGGCTTTATTTGGACTTGCTGTCATTTTTACTATCGTTTCAAGTACGATTACTGTTATTGGACCTGACCGGCTGAAAGAGATGACAGATACCATGACCAAAGGGCTGGCAGGAAAAATTGATTTAGATAAAATCGGTGAGATTGCTCTAACCTTGGCTCTCTTATACTTTGCTGGTGCTTTGGTTTCTTATACTGCTAGCTTTATTGTGTCCACTTTGATTCAAAAGTTTTCGCAACGTCTGCGCAATGCCATTGCAGATAAAATCAATAAGGTACCGCTCAAATATTTTGACAGCCATTCACAAGGAGATACCTTGTCTCGAGTGACCAATGATGTGGATTTAATGACACAGTCTTTCAACCAAAGTTTAGTTTCAATGGTAGCAGCTATAATTCTCCTGATTGGCTCTATTTTCATGATGATTAAAACCAATGGAGCTCTTGCAGCGACCGCTATTTTGTCTGTTTTTGCTGGTTTTGTGTTATCCACTGTTATCATGGCCAAGAGCCAGCCGCTTTTTAAAAAGCAACAAGCTAATCTAGCCGATGTCAGCGGTTATGTTGAAGAGGTCTATTCAGGTCATAATGTGGTTTCTAGTTACAATGCGATTCAGCAAAGCAAGAAGCAGTTTGAAAACTTGAATGACCAATTATTTGCAAGTATGTGGAAATCACAATTCTTTTCTGGAATTATGATGCCCCTTATGCAATTCATCGGAAATTTTGGGTATGTCATGGTCTGTATTGTCGGTGCTACCATGGCTATTAACGGCGATATTACTATGGGAACGATTGTTGCCTTTATGACTTACGTCCGTATTTTTACTCAGCCCATTGCGCAGATTGCTCAAGGAATCACTCAATTGCAATCAGCTAATGCTGCTATGGGACGTGTCTTTGAATTTCTTGATGAGGAAGAAATAGAAGACGAAAACCATAAAGTTAAACAACTTGAAAAAGTTGAAGGAAATGTTAATTTTGACAATGTTTTCTTTGGTTATAGTCCTGATAAAACTATTATTCATGATTTCTCGGCTCATGCTAAGGCTGGTCAAAAAATTGCTATTGTGGGACCGACTGGTGCGGGTAAGACAACGATTGTTAACTTACTTATGCGTTTCTATGAGGTTGATAGAGGGATGATTTCTATTGATGGAGTTAATATCCATGATATGACACGAAAAGAAGTGCATGATGCTTTTGCCATGGTACTCCAAGATACTTGGCTCTTTGAAGGTACAGTTAAGGAAAATCTGATTTATAATCAAAAACATATCACTGATGAGCAAGTGATTGCAGCAGCTAAGGCAGTTGGTGTTCATCATTTCATCAAGACTTTACCTAAGGGTTATGATACTGTTTTAGATGATTCGGTCACCTTATCAGTCGGTCAAAAACAACTCTTGACCATTGCACGTGCTCTTCTTAAAGATGCACCGCTTCTGATTCTTGATGAAGCAACTTCCTCTGTTGATACTCGTACGGAAGAACTTATTCAAAGGGCTATGGATCATTTGATGGAGGGGCGGACATCATTCGTTATTGCCCATCGTCTGTCAACTATTCGCAATGCTGATCTTATTCTTGTCATGAGAGATGGTAATATTATTGAACAAGGCAGCCATGACCAATTGATGGCAGAAAATGGCTTCTATGCCGATCTCTATAATAGTCAATTTACAGAAGAAGTGGCTTGA","6.10","-6.88","64583","MENKKKSLLSQMAPYLKGYKALFGLAVIFTIVSSTITVIGPDRLKEMTDTMTKGLAGKIDLDKIGEIALTLALLYFAGALVSYTASFIVSTLIQKFSQRLRNAIADKINKVPLKYFDSHSQGDTLSRVTNDVDLMTQSFNQSLVSMVAAIILLIGSIFMMIKTNGALAATAILSVFAGFVLSTVIMAKSQPLFKKQQANLADVSGYVEEVYSGHNVVSSYNAIQQSKKQFENLNDQLFASMWKSQFFSGIMMPLMQFIGNFGYVMVCIVGATMAINGDITMGTIVAFMTYVRIFTQPIAQIAQGITQLQSANAAMGRVFEFLDEEEIEDENHKVKQLEKVEGNVNFDNVFFGYSPDKTIIHDFSAHAKAGQKIAIVGPTGAGKTTIVNLLMRFYEVDRGMISIDGVNIHDMTRKEVHDAFAMVLQDTWLFEGTVKENLIYNQKHITDEQVIAAAKAVGVHHFIKTLPKGYDTVLDDSVTLSVGQKQLLTIARALLKDAPLLILDEATSSVDTRTEELIQRAMDHLMEGRTSFVIAHRLSTIRNADLILVMRDGNIIEQGSHDQLMAENGFYADLYNSQFTEEVA","878573","For other components see SMu0836 (NBD1 and MSD1) and SMu0837 (NBD2). ","ABC-type multidrug/protein/lipid transport system,ATPase component","Membrane, Cytoplasm","Several matches in gapped BLAST to ABC transporter, ATP-bindingprotein: residues 49-580 are 50% similar to the protein in Clostridium acetobutylicum (gi|15896526|). Residues 6-580 are 43% similar to the protein from Listeria monocytogenes(gi|16802650|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (1e-129).","

InterPro
IPR000362
Domain

Fumarate lyase
PS00163	$\"[155-164]?$	FUMARATE_LYASES

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[19-298]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[479-522]T$	ABC_transporter
PF00005	$\"[370-553]T$	ABC_tran
PS00211	$\"[480-494]?$	ABC_TRANSPORTER_1
PS50893	$\"[344-577]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[369-554]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[25-310]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[309-575]T$	G3DSA:3.40.50.300
PTHR19242	$\"[1-582]T$	PTHR19242
PTHR19242:SF91	$\"[1-582]T$	PTHR19242:SF91
SSF52540	$\"[344-582]T$	SSF52540
SSF90123	$\"[1-325]T$	SSF90123

InterPro
IPR002065
Family

Antioxidant Tpx
PTHR10681:SF3	$\"[7-161]T$	TPX
PS01265	$\"[81-92]T$	TPX

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[1-161]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[1-161]T$	IPR012336

InterPro
IPR013740
Domain

Redoxin
PF08534	$\"[17-160]T$	Redoxin

noIPR
unintegrated

unintegrated
PTHR10681	$\"[7-161]T$	PTHR10681

","BeTs to 5 clades of COG2077COG name: Thiol peroxidaseFunctional Class: OThe phylogenetic pattern of COG2077 is -----q--ebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002065 (Tpx family) with a combined E-value of 2.1e-86. IPB002065A 2-52 IPB002065B 58-106 IPB002065C 124-157***** IPB000866 (AhpC/TSA family) with a combined E-value of 5.3e-10. IPB000866A 46-61 IPB000866B 77-91 IPB000866C 111-120","Residues 80-160 are 45% similar to a (PEROXIDASE 1.11.1.- THIOL OXIDOREDUCTASE) protein domain (PD414026) which is seen in TPX_MYCTU.Residues 3-68 are 39% similar to a (PEROXIDASE 1.11.1.- THIOL OXIDOREDUCTASE) protein domain (PD407017) which is seen in Q9ZIQ5_HELPY.Residues 2-79 are 82% similar to a (PEROXIDASE OXIDOREDUCTASE THIOL 1.11.1.-) protein domain (PD006582) which is seen in TPX_STRSA.Residues 80-161 are 75% similar to a (PEROXIDASE ANTIOXIDANT PEROXIREDOXIN COMPLETE PROTEOME) protein domain (PD000721) which is seen in TPX_STRPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Mar 9 15:37:57 2003","Thu Jan 3 13:33:43 2002","Sun Oct 27 20:26:46 2002","Thu Jan 3 13:33:43 2002","Thu Jan 3 13:33:43 2002","Thu Jan 3 13:33:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0838 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 13:36:11 2002","","No significant hits to the NCBI PDB database.","SMU.924","","Residues 18 to 157 (E-value = 1.6e-36) place SMu0838 in the AhpC-TSA family which is described as AhpC/TSA family (PF00578)","Thu Jan 3 13:33:43 2002","24379369","","","Cha,M.K., Kim,H.K. and Kim,I.H.Thioredoxin-linked 'thiol peroxidase' from periplasmic space ofEscherichia coliJ. Biol. Chem. 270 (48), 28635-28641 (1995)PubMed: 7499381","","Sun Mar 9 15:37:57 2003","1","","","SMU.924","814" "SMu0839","879393","879863","471","ATGCTGTATTGTACAGCCAACTATATGAATATTATTTTAGGTGAGGAGAAAGATATGTCCAGAAAGAAAAGTCGGAAACTGAAGTTATTGAGACTTTTAACAGCACAGCTTATTGCTATTTGTTTGTTAATTATGGTTTTGACACAAGCTATTTTTAAATCTCCTCTGCTTGTTCAGGTTTGCTTTTTAATTATAACGCTTTGTACAGCTGGTCTGAATTATTATTTCATTAAAGAAGCTAGAGAGGCAAATGCACAAGAAAGTTCTGCTGCTACAGTTACTAGTCAAGTTATCTTTACTGTCGTGTTTTTGCTTTTGATGGTTTTAAGCGGTTATAAGGCCATTCAAGTAAGCGAATTTGCCAGTAAGATCATCTTCTCAGCTGCTGCTGTAATTAGTTTTATTGTCTCTCTTCTTTTATTATGGGGAATAAGATATGTCAAAAAAACCAGCTTTTTTAGAAAACGCTAA","10.60","11.79","17604","MLYCTANYMNIILGEEKDMSRKKSRKLKLLRLLTAQLIAICLLIMVLTQAIFKSPLLVQVCFLIITLCTAGLNYYFIKEAREANAQESSAATVTSQVIFTVVFLLLMVLSGYKAIQVSEFASKIIFSAAAVISFIVSLLLLWGIRYVKKTSFFRKR","879862","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu0839 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-48]?$	signal-peptide
tmhmm	$\"[29-47]?$ $\"[57-77]?$ $\"[92-110]?$ $\"[124-144]?$	transmembrane_regions

InterPro
IPR007685
Domain

RelA/SpoT
PF04607	$\"[46-171]T$	RelA_SpoT

noIPR
unintegrated

unintegrated
PTHR21262	$\"[42-202]T$	PTHR21262
SSF81301	$\"[4-193]T$	SSF81301

","BeTs to 8 clades of COG0317COG name: Guanosine polyphosphate pyrophosphohydrolases/synthetasesFunctional Class: T,KThe phylogenetic pattern of COG0317 is -----qvcEbrHujgpo----Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 42-202 are 40% similar to a (SYNTHETASE PROTEOME COMPLETE KINASE) protein domain (PD002902) which is seen in Q9CH66_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 15:30:32 2002","Tue Mar 27 12:42:41 2007","Tue Mar 27 12:42:41 2007","Thu Jan 3 13:47:55 2002","","Thu Jan 3 13:47:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0840 is paralogously related (blast p-value < 1e-3) to SMu0955, a predicted GTP pyrophosphokinase and SMu1856, a predicted GTP pyrophosphokinase (stringent response-like protein) (PPGPPsynthetase I).","Fri Jan 25 15:30:16 2002","","No significant hits to the NCBI PDB database.","SMU.926","","Residues 46 to 173 (E-value = 2.1e-42) place SMu0840 in the RelA_SpoT family which is described as Region found in RelA / SpoT proteins (PF04607)","Thu Jan 3 13:47:55 2002","24379371","","","","","","1","","","SMU.926","" "SMu0841","880715","881401","687","ATGTCTTTAACGATTTTACTAGCAGAAGACGAAGAGCAGTTGTCGCGTGTTTACACAGCAGCTTTAAAGCATCAAGGTTATCAAGTTGATCAAGTTTATAATGGACAAGATGCTATCGAAAAAGCACATGAAAATGCTTATGATGTTTTTATTTTAGATATCATGATGCCAATTAAAACCGGCTTGGAAGCTTTGCGTGAGATTCGTGCCAGTGGGGATCATACGCATGCTATTATGTTGACAGCTATGTCGGAAATTGAAGACAAAGTAACTGGTTTAGAGGCAGGTGCTGATGATTATTTAACCAAGCCTATTTCTTTAAAGGAACTTTTAGCGCGCTTGGCTTCCTTAGAACGGCGTCTGGATCGTTTTACGGATAAAGTTTTAACTTTTGGCAGTGTCAAACTTGATCTTGCCCAGCAAGAAATGGTGTCAGGCAATTCTATTCGTTTAGCAGGAAAAGAATCAAAATTGATGGCTTTTTTTATGCTTAATCCTAATAAATCTTTATCAACCAAAGAAATTTTTCAGCATGTTTGGGCAAAAGATGATGATCCTGAAATTGATGAAGGTTATGTCTTCATCTATATTTCTTATCTTAGACAAAAACTAAAATCTATTAAGGCAAATCTTGCTATCTTAGGAGAAGAGAATGGCGATTTTACCTTAGTTAGAATTGGCGGGTGA","4.90","-8.78","25618","MSLTILLAEDEEQLSRVYTAALKHQGYQVDQVYNGQDAIEKAHENAYDVFILDIMMPIKTGLEALREIRASGDHTHAIMLTAMSEIEDKVTGLEAGADDYLTKPISLKELLARLASLERRLDRFTDKVLTFGSVKLDLAQQEMVSGNSIRLAGKESKLMAFFMLNPNKSLSTKEIFQHVWAKDDDPEIDEGYVFIYISYLRQKLKSIKANLAILGEENGDFTLVRIGG","881400","For other 'llr' genes see SMu0918 (llrG).","response regulator","Cytoplasm","Matches to gcrR:residues 1-204 are 30% similar to the previously published protein in S.mutans (gi6174678). Several matches in gapped BLAST to response regulator: residues 3-224 are 55% similar to the protein in S.pyogenes (gi15674899). Residues 3-206 are 37% similar to the protein from Mycobacterium tuberculosis (gi15840463).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1328 (6e-72).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[4-105]T$	Response_reg
PF00072	$\"[3-115]T$	Response_reg
SM00448	$\"[3-114]T$	REC
PS50110	$\"[4-118]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[128-210]T$	Trans_reg_C
PF00486	$\"[146-213]T$	Trans_reg_C

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[2-189]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[3-154]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[4-123]T$	PTHR23283
PTHR23283:SF21	$\"[4-123]T$	PTHR23283:SF21

","BeTs to 8 clades of COG0745COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG0745 is -----QVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 10","***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 4.6e-36. IPB001867A 48-61 IPB001867B 76-120 IPB001867C 149-180***** IPB001789 (Response regulator receiver domain) with a combined E-value of 7.3e-11. IPB001789B 48-61 IPB001789C 96-105***** IPB000673 (CheB methylesterase) with a combined E-value of 5.1e-08. IPB000673B 20-73 IPB000673C 74-104","Residues 5-104 are 46% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in Q9KFU9_BACHD.Residues 129-205 are 34% similar to a (DNA-BINDING TRANSDUCTION SENSORY TRANSCRIPTION) protein domain (PD000329) which is seen in Q9CF06_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 31 17:22:13 2006","Tue Jan 8 11:43:11 2002","Mon Jul 31 17:22:13 2006","Thu Jan 3 13:51:46 2002","Thu Jan 3 13:51:46 2002","Thu Jan 3 13:51:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0841 is paralogously related (blast p-value < 1e-3) to SMu1032, SMu1748, SMu1379, SMu1048, SMu0601, SMu1653, SMu0947, SMu0918, SMu1406, SMu1782, and SMu0441 all predicted response regulators.","Fri Jan 25 15:32:22 2002","Mon Jul 31 17:22:13 2006","pdb1B00A Chain A, Phob Receiver Domain From Escherichia Coli ... 68 1e-012","SMU.927","","Residues 3 to 122 (E-value = 5.1e-34) place SMu0841 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 146 to 213 (E-value = 3.8e-09) place SMu0841 in the Trans_reg_C family which is described as Transcriptional regulatory protein, C terminal (PF00486)","Mon Jul 31 17:22:13 2006","24379372","","Sato,Y., Yamamoto,Y. and Kizaki,H.Construction of region-specific partial duplication mutants(merodiploid mutants) to identify the regulatory gene for theglucan-binding protein C gene in vivo in streptococcus mutansFEMS Microbiol. Lett. 186 (2), 187-191 (2000)PubMed: 10802169","","Thu Mar 21 08:22:08 2002","","1","","","SMU.927","" "SMu0842","881401","882639","1239","ATGAGCATGTTTCGTAAGATCAGATTCCGTTTTATCCTTGTCGCCTCTTTTGCTATCTTATGTATCCTCATTTCTTTTGTGGGTGTTTTTAATTCTGTTCGTTATGTTCAAAATAACGATGAGATCAATGCTATTTTGACCATTTTATCTAGAAATAAAGGAGAATTTCCTGATCCGATAGAAATTAACAAGGAGGTAGGAAATCGAGGATTGTCAGTAGCTGTTATTAATCAATACCAATATTACAGTTTTATAGTGGATAGGAAAAAAGATACCGTTTCTCTTAATCTAAGTCATATTTCTCATTTGACAGAAGAACAGGCAGAGTCTTATATGAGAAATATTAATCTCCATGAAAGAGACGGACGTTTTAGAAAAAACAATCATTTTTATTCTTACCGTGTGACAAAAATGAATCCATCTGGCCGCTATTTGGTTGTTGTCTTGGATGCTACTCGTTTTTTTGCTGATCGTTCTGAACTAATCAATCTTTCTATTCAAATGTCCTTTTACAGTTTGCTCTTTTTCATTTTAGTTGTTTCTGTTTTTTCAGGCTATGCTATTAAGCCTTACCTTGAAAATTATGAGAAACAAAAACGCTTTATTACTAATGCTGGACATGAATTAAAAACCCCTTTATCCATTATTTCTGCTAATAATGAATTGCAAGAATTAATGACTGGCGAAACAGAATGGACCAAAAGTACCAAGGATCAAGTTGAACGCTTGACCCATTTAATCAATCAATTAGTTACTTTGGCTAGGTTAGAAGAGCAGCCGAATATTGTTCTTGAAAGAGTTTGTTTTTCGGAAATTGTGCAAGATGCAGCAGAAGACTTTAAAGCTCCCATCATTAAAGATGGTAAAACGTTTGAGATGCAGATTGCTTCTGATATTTATGTCAAAGCAGAAGAAAAGTCCCTCTTTGAATTGGTCACTCTTTTAGTAGATAATGCTAATAAATATTGTGATGATAAGGGGACAGTAAGTGTCAAACTTAGCAGAACCAGTGGTCTTAAAAAGGCAAGACTAGAGGTTTCAAATACCTTTAAAGAAGGTACTGAAATTGATTATAGCCGTTTCTTTGACCGCTTTTATCGCGAAGATGAATCGCATAACAATCAGACATCAGGTTATGGCATCGGATTGTCAATGGCTCAGAGTATTGTTAAAATTTTTAAAGGAAAAATTTCGGTCTCCTATAAGAATGATGCCATTACTTTTAAGGTTATTTTATAA","8.70","4.58","47502","MSMFRKIRFRFILVASFAILCILISFVGVFNSVRYVQNNDEINAILTILSRNKGEFPDPIEINKEVGNRGLSVAVINQYQYYSFIVDRKKDTVSLNLSHISHLTEEQAESYMRNINLHERDGRFRKNNHFYSYRVTKMNPSGRYLVVVLDATRFFADRSELINLSIQMSFYSLLFFILVVSVFSGYAIKPYLENYEKQKRFITNAGHELKTPLSIISANNELQELMTGETEWTKSTKDQVERLTHLINQLVTLARLEEQPNIVLERVCFSEIVQDAAEDFKAPIIKDGKTFEMQIASDIYVKAEEKSLFELVTLLVDNANKYCDDKGTVSVKLSRTSGLKKARLEVSNTFKEGTEIDYSRFFDRFYREDESHNNQTSGYGIGLSMAQSIVKIFKGKISVSYKNDAITFKVIL","882638","For other 'kin' genes see SMu0919 (kinG) and SMu1031 (kinF).","sensor histidine kinase","Membrane, Cytoplasm","Several matches in gapped BLAST to two-component sensory transduction histidine kinase: residues 3-412 are 56% similar to the enzyme in S.pyogenes (gi15674900). Residues 174-399 are 29% similar to the protein from Lactococcus lactis subsp lactis (gi15673656).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1327 (1e-125).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[264-412]T$	ATP_bd_ATPase
PF02518	$\"[303-400]T$	HATPase_c
SM00387	$\"[303-412]T$	HATPase_c
SSF55874	$\"[248-412]T$	ATP_bd_ATPase

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[197-259]T$	HisKA
SM00388	$\"[197-259]T$	HisKA

InterPro
IPR004358
Domain

Histidine kinase related protein, C-terminal
PR00344	$\"[360-370]T$ $\"[377-395]T$	BCTRLSENSOR

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[204-412]T$	HIS_KIN

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[187-255]T$	His_kin_homodim

noIPR
unintegrated

unintegrated
PTHR23283	$\"[187-412]T$	PTHR23283
PTHR23283:SF34	$\"[187-412]T$	PTHR23283:SF34

","BeTs to 12 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 188-399 are 22% similar to a (KINASE PROTEOME COMPLETE TRANSFERASE) protein domain (PD113037) which is seen in O25917_HELPY.Residues 195-265 are 37% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD150714) which is seen in Q9I5H2_PSEAE.Residues 201-410 are 24% similar to a (KINASE PROTEOME COMPLETE HISTIDINE) protein domain (PD121357) which is seen in O24971_HELPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 31 17:22:42 2006","Mon Jul 31 17:15:12 2006","Mon Jul 31 17:15:12 2006","Thu Jan 3 13:58:15 2002","","Thu Jan 3 13:58:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0842 is paralogously related (blast p-value < 1e-3) to SMu1031, SMu1378, SMu0946, SMu0602, and SMu1652 all predicted histidine kinases.","Fri Jan 25 15:33:42 2002","","No significant hits to the NCBI PDB database.","SMU.928","","Residues 197 to 259 (E-value = 1.8e-11) place SMu0842 in the HisKA family which is described as His Kinase A (phosphoacceptor) domain (PF00512)Residues 303 to 406 (E-value = 1.9e-08) place SMu0842 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Mon Jul 31 17:15:12 2006","24379373","","","O'Connell-Motherway,M., van Sinderen,D., Morel-Deville,F.,Fitzgerald,G.F., Ehrlich,S.D. and Morel,P.Six putative two-component regulatory systems isolated fromLactococcus lactis subsp. cremoris MG1363Microbiology 146 (Pt 4), 935-947 (2000)PubMed: 10784052","","Mon Jul 31 17:22:42 2006","1","","","SMU.928","693" "SMu0843","883045","882695","351","ATGTCAATTATTAAAATGCTTATTATCATTCTGGTCGCTTTGGAATTCTTTTACATTATGTATTTGGAAACGTTAGCCACACAGTCTACAAAGACATCTCAAGTTTTTGGCATGACTCAAGAAACATTAGGTGAAAAAGAAATTGATGTCCTGTTTAAAAATCAAGGTATTTATAATGGCCTTCTTGGTTTAGGTCTGCTTTATGGCTTAGCTTTTAATACAGCTATCATTTTACCAATCTTGATTTACATTATTCTTGTTGCTGCGTATGGTGCTTATAGCAGCAATCCAAAAATTTTGCTGACACAGGGAGGGTTAGCCATTATCGCTGCACTGCTTTATCTCTTTTAA","4.90","-1.02","12743","MSIIKMLIIILVALEFFYIMYLETLATQSTKTSQVFGMTQETLGEKEIDVLFKNQGIYNGLLGLGLLYGLAFNTAIILPILIYIILVAAYGAYSSNPKILLTQGGLAIIAALLYLF","882700","","conserved hypothetical protein","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical protein: residues 1-59 are 59% similar to the protein in S.aureus (gi|15923410|).Residues 4-58 are 52% similar to the protein from S.pneumoniae (gi|15903914|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2133 (7e-14).","

InterPro
IPR009732
Family

Protein of unknown function DUF1304
PF06993	$\"[3-116]T$	DUF1304

noIPR
unintegrated

unintegrated
PD076489	$\"[4-98]T$	PD076489

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-59 are 59% similar to a (PROTEOME COMPLETE 5'REGION NMB0528) protein domain (PD076489) which is seen in YTRP_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 25 15:34:26 2002","Thu Jan 3 14:06:58 2002","Fri Jan 25 15:34:26 2002","Thu Jan 3 14:06:58 2002","","Fri Jan 25 15:34:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0843 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 25 15:34:26 2002","","No significant hits to the NCBI PDB database.","SMU.929c","","Residues 3 to 116 (E-value = 8.2e-65) place SMu0843 in the DUF1304 family which is described as Protein of unknown function (DUF1304) (PF06993)","Thu Jan 3 14:06:58 2002","24379374","","","","","","1","","","SMU.929c","988" "SMu0844","884103","883192","912","ATGAATTTTCAACAATGTCGTTATGTTGAGGCTATTGCCAATACAGGTTCTTTTAGTGAAGCTGCTAAAAAACTTTATGTCACACAGCCCAATCTTTCCTCTTCAATTAAAGAGTTAGAAAATGACTTAGGAGTACAGCTTTTTATTCGCTCTAATACGGGTGCTCGCCTAACAGATGATGGTTATGATTTTCTTAAGTATGCTAAACGCATTTTGGGAGAAGCTGATCTTCTTAAAAAACGCTACCAAGACAACTACAAAAAGAGCTTTACCATTAGTTCGCATCACTATGATTTTCTAGCCATTCCGCTTCTTGAAATAGCCGAAAAATTCAAAAAAGACTTTCAACATTTTCACCTGATTGAGACAACAACCAAAAAAATCTTAGAAAGCGTCTTAAATTTTGAAAGTGACTTGGGTATTCTTTATCTTAACGACGATAATCGTCATATTTTAGAACGTTATTTTAAACAGCATGATCTTGCTTTTACACCTCTCGGGGATTTTCCTACACGGATTTTCCTTAGAAAAGATCATCCGCTCGCCCAGCAAAAGGTCATTGAAAAAGTGCAATTAAAAGATTATAAGCAAGTCCGTTTCAGACAAGAAATTTCAGGACTTAACTTTGACGAAGATACCCTTGATATTCCTGAAAATCAATCTGTCTTTTACAGTAATGATCGCGGTACTATCATGAATATCCTCTGTGGTTCAGATGCTTATGCTTCAGGATTGGGTATTGTTAACAGTTTTATCAAGGATCAAATTGTTCTAATCCCTCTTAAAGACAGCAAAATGCATACCCTTGGTTTTGTTAGCAATAAACGTAAACAAGAAACTGATATTACTCAGCAATTCATTACTGCTGTTAAAAACAGTCTTAGAACATACGAAAGGGGAACACAATTGTGA","8.10","2.84","35090","MNFQQCRYVEAIANTGSFSEAAKKLYVTQPNLSSSIKELENDLGVQLFIRSNTGARLTDDGYDFLKYAKRILGEADLLKKRYQDNYKKSFTISSHHYDFLAIPLLEIAEKFKKDFQHFHLIETTTKKILESVLNFESDLGILYLNDDNRHILERYFKQHDLAFTPLGDFPTRIFLRKDHPLAQQKVIEKVQLKDYKQVRFRQEISGLNFDEDTLDIPENQSVFYSNDRGTIMNILCGSDAYASGLGIVNSFIKDQIVLIPLKDSKMHTLGFVSNKRKQETDITQQFITAVKNSLRTYERGTQL","883197","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator: residues 1-297 are 36% similar to the protein in Lactococcus lactis subsp. lactis (gi|15672313|). Residues 1-284are 36% similar to the protein from S.pneumoniae (gi|15900807|)The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1367 (2e-48).","

InterPro
IPR000847
Domain

Bacterial regulatory protein, LysR
PR00039	$\"[18-29]T$ $\"[29-39]T$ $\"[39-50]T$	HTHLYSR
PF00126	$\"[3-62]T$	HTH_1
PS50931	$\"[1-58]T$	HTH_LYSR

InterPro
IPR005119
Domain

LysR, substrate-binding
PF03466	$\"[117-201]T$	LysR_substrate

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-87]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[117-207]T$	G3DSA:3.40.190.10
SSF46785	$\"[1-84]T$	SSF46785
SSF53850	$\"[83-295]T$	SSF53850

InterPro
IPR000257
Family

Uroporphyrinogen decarboxylase (URO-D)
PD003225	$\"[106-310]T$	Uro_decarbxyls

InterPro
IPR002110
Repeat

Ankyrin
PR01415	$\"[223-235]T$ $\"[294-306]T$	ANKYRIN

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.210	$\"[5-334]T$	G3DSA:3.20.20.210
SSF51726	$\"[3-334]T$	SSF51726

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[38-276]T$	SBP_bac_3
SM00062	$\"[37-277]T$	PBPb

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[36-176]T$	G3DSA:3.40.190.10
SSF53850	$\"[33-282]T$	SSF53850

","BeTs to 8 clades of COG0834COG name: Periplasmic amino acid binding proteinsFunctional Class: EThe phylogenetic pattern of COG0834 is A-----VCEBrHUJ---LINxNumber of proteins in this genome belonging to this COG is 8","No significant hits to the Blocks database.","Residues 25-141 are 34% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT ABC TRANSPORTER) protein domain (PD245531) which is seen in YTMK_BACSU.Residues 189-278 are 36% similar to a (AMINO TRANSPORTER ABC PERIPLASMIC) protein domain (PD090480) which is seen in YCKK_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 13:11:21 2002","Thu Jan 3 14:55:33 2002","Sat Oct 12 13:11:21 2002","Thu Jan 3 14:48:40 2002","","Thu Jan 3 14:48:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0846 is paralogously related (blast p-value < 1e-3) to SMu1765, SMu0416, SMu1112, SMu1078, SMu0741, SMu0732, SMu0739, and SMu0219, all predicted permeases.","Fri Jan 25 15:38:06 2002","","No significant hits to the NCBI PDB database.","SMU.933","","Residues 38 to 276 (E-value = 2.9e-20) place SMu0846 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)","Thu Jan 3 14:48:40 2002","24379377","","","","","","1","","","SMU.933","" "SMu0847","886256","886948","693","ATGGTTTCTTATACACCATCTTATGTTTTTAAATTTTTGCCAACTATTTTAAATGCTCTTCCTTTAACGTTGTGGGTCATTTTTTTAACCGTTCTTTTAGGTTCTTTGTTGGGAGCAGGTCTGGCTTGGGCACAAGTGGATTCTAAAAACAGCTGGGCAGCCTTTGCTAAAGGATATGTTTTTATTTTGAGATGTACACCGCCAATTGTTTTGCTCTTTCTTGTTTTTTATGGTCTGCCAGAATTTTTGACTTGGTGGCTTCATTTGGATGTTGACGATTGGTCACGTGCTATTTTTGTCGTTGTAACTATGGTATTACTATTTGCGGCCTCAATTTCTGAAGTTTTCAAATCAGCTTATTTAGCTGTACCTAAGGGACAATTAGAAGCTGGTCTCAGTATTGGTCTAACTGGCTTTCAAACCTTTAGGCGTATTCTTTTGCCGCAGACCTTTCAAATCGCCTTACCCAATATAACAACTGCCATTTTAAATTTGATGAAAGATGCGGCTCTAGCCTATACAATCGGTTTAGTAGATGTCATGGGGGCAGGAAATCTGATTATTAGTCGGAATTTGGGGAACTATTCTCTGGAAACTTATACAGCTGTTGCCTTTATTTATTGGGGAATTGCCTTAGTTTTGTCACTGGTATCACATTTTATGGAACACAGTCTTAATAAAGGAAATACTTAG","8.40","1.66","25406","MVSYTPSYVFKFLPTILNALPLTLWVIFLTVLLGSLLGAGLAWAQVDSKNSWAAFAKGYVFILRCTPPIVLLFLVFYGLPEFLTWWLHLDVDDWSRAIFVVVTMVLLFAASISEVFKSAYLAVPKGQLEAGLSIGLTGFQTFRRILLPQTFQIALPNITTAILNLMKDAALAYTIGLVDVMGAGNLIISRNLGNYSLETYTAVAFIYWGIALVLSLVSHFMEHSLNKGNT","886947","For other components see SMu0849 (NBD1); SMu0848 (MSD1) and SMu0846 (SBP1).This protein is probably part of a binding-protein-dependent transport system for an amino acid.It probably is responsible for the translocation of the substrate across the membrane [gi:1175700].","amino acid ABC transporter, permease protein","Membrane, Cytoplasm","Several matches in gapped BLAST to amino acid ABC transporter, permease protein: residues 12-230 are 34% similar to the enzyme in Listeria innocua (gi|16801504|). Residues 9-225 are 26% similar to the protein from S.pyogenes (gi|15675528|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0291 (1e-22).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[16-227]T$	BPD_transp_1
PS50928	$\"[16-218]T$	ABC_TM1

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[12-118]T$	HEQRo_perm_3TM

","BeTs to 7 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","***** IPB000515 (Binding-protein-dependent transport systems inner membrane component) with a combined E-value of 9.4e-07. IPB000515 129-148","Residues 101-149 are 53% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in Q9JV45_NEIMA.Residues 154-230 are 31% similar to a (AMINO-ACID TRANSPORT YTML ABC) protein domain (PD392389) which is seen in YTML_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 13:12:03 2002","Thu Jan 3 14:57:50 2002","Sat Oct 12 13:12:03 2002","Thu Jan 3 14:57:50 2002","Thu Jan 3 14:57:50 2002","Thu Jan 3 14:57:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0847 is paralogously related (blast p-value < 1e-3) to SMu1111, SMu0848, SMu1080, SMu0417, SMu0732, SMu0516, SMu1382, SMu0219, SMu1383, SMu1039, and SMu1038, all predicted permeases.","Fri Jan 25 15:39:49 2002","","No significant hits to the NCBI PDB database.","SMU.934","","Residues 16 to 227 (E-value = 2.7e-16) place SMu0847 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Thu Jan 3 14:57:50 2002","24379378","","","Rodriguez,F. and Grandi,G.An operon encoding a novel ABC-type transport system in BacillussubtilisMicrobiology 141 (Pt 7), 1781-1784 (1995)PubMed: 7551042","","Thu Jan 3 15:02:32 2002","1","","","SMU.934","" "SMu0848","886957","887631","675","ATGGATTTTTCTTATATTTTTCATACATTTTTACTTTCCTTAAAGGGTGTTCCTGTGACCTTAGTCATCATGATAGTCTCTATACTGCTGAGCTTTTTACCGGCTTTGTTTTTGGCTTTGGGCAGAATTTACAAGGTAAAAGGTGTGACGACTTTTTCGATTGTTTATCTAGCTTTTATTAGAGCAACACCGCCTATTCTTTTGATTCTCTTTTTTTACAGTCTTTTACCCAGTGTTTTAAATACCATTTTAAAATCAAGCGGATTAGATATTTTTAAACTTAATCCTATTTATTATGCTTTTATTATCTTTAGTCTAATGACAACAGGGAGTCTATCAGAAATTTTACGCTCTGCTATTTTAACGGTTGATAAGGGACAGTTGGAAGCAGCTCAGTCTATTGGTTTAACAACGACACAAAGTTATCTCAGAATTATTTTTCCACAGGCTTTGAGGTCTGCTCTTCCCAATCTTTGTAATTTGGTGATTAATATTGTTAAAGGAACTTCGCTTGTTTTTGTCATGACAGTTAAGGATATTACAGCAATAGCTAAGGTTGAAGCGGCTCATGGTTACCAATATTTTGAATCTTATCTTGTGATTTTCATTATTTATATTATTATTTGTGGTTTGATTCAGTGGAGCTTTTCAACTTTAGAAAAGCGTTTTGCTTAA","10.20","7.37","25017","MDFSYIFHTFLLSLKGVPVTLVIMIVSILLSFLPALFLALGRIYKVKGVTTFSIVYLAFIRATPPILLILFFYSLLPSVLNTILKSSGLDIFKLNPIYYAFIIFSLMTTGSLSEILRSAILTVDKGQLEAAQSIGLTTTQSYLRIIFPQALRSALPNLCNLVINIVKGTSLVFVMTVKDITAIAKVEAAHGYQYFESYLVIFIIYIIICGLIQWSFSTLEKRFA","887630","For other components see SMu0849 (NBD1); SMu0847 (MSD2) and SMu0846 (SBP1).","amino acid ABC transporter, permease protein","Membrane, Cytoplasm","Several matches in gapped BLAST to amino acid ABC transporter,permease protein: residues 10-222 are 33% similar to the protein in Listeria monocytogenes (gi|16804386|). Residues 14-199 are 31% similar to the protein from S.pyogenes (gi|15675528||). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0291 (1e-24).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[13-224]T$	BPD_transp_1
PS50928	$\"[17-213]T$	ABC_TM1

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[10-118]T$	HEQRo_perm_3TM

","BeTs to 7 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 88-150 are 44% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in YTML_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 13:12:31 2002","Thu Jan 3 15:13:09 2002","Mon Oct 28 08:28:40 2002","Thu Jan 3 15:13:09 2002","","Thu Jan 3 15:13:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0848 is paralogously related (blast p-value < 1e-3) to SMu0417, SMu1111, SMu0847, SMu0732, SMu1383, SMu1080, SMu0219, SMu1382, SMu0516, and SMu1426, all predicted permeases.","Fri Jan 25 15:41:33 2002","","No significant hits to the NCBI PDB database.","SMU.935","","Residues 13 to 224 (E-value = 3.3e-07) place SMu0848 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Thu Jan 3 15:13:09 2002","24379379","","","","","","1","","","SMU.935","" "SMu0849","887641","888405","765","ATGTTAGAAATTAAAAATTTATCAAAACAATTTGGAGATAAACTTGTTCTTGACAATGTTAGCTTGACTGTTAACAAGGGAGATGTTGTCGTTATTTTGGGTCCTAGCGGTTCAGGAAAAACAACTTTTTTGCGCTGTCTTAATCATTTGGAAAAAGCAGATAAAGGACATCTAACTTTAGATGGACAATCTTATGATTTGGCAACACTTAATCGTAAAGAAATTTTGACCATTCGGCAAAAGACGGCCTTTGTTTTTCAACACTATAATCTTTTTGCTAATAAAACCGCTTTGGAGAATATTTTAGAAGGCTTAATGACTGCAAGAAAGATTCCCAAAGAACAAGCGATTCAAATTGCGGAGCAAGCCCTTGAAAAGGTAGGCTTATTGAGTTATAAAGATTATTATCCTAGTCAATTATCTGGTGGTCAGCAGCAAAGAATTGGGATTGCACGTGCCATTGCAGTCAAGCCAGATCTTATCTTTTTTGATGAACCAACATCGGCACTTGACCCTGAATTGATTGGTGATGTTTTGGGTGTCATGAAACAATTGGCTGAGGAAGGCGTTACCATGATTGTGGTCACGCATGAAATGAGTTTTGCCAAAGATGTGGCCAATCATGTCATTTTTATGGATGGTGGGCACATCATCGAAGAAGCTTCGCCAAAAGAATTTTTCTCGAAACCTAAAGAAGACAGGACGCGTCGCTTTTTAGCCCGGATTCTGTCTGATGATAGTTACTCAGTTGATTATATATTGTAA","6.30","-2.59","28343","MLEIKNLSKQFGDKLVLDNVSLTVNKGDVVVILGPSGSGKTTFLRCLNHLEKADKGHLTLDGQSYDLATLNRKEILTIRQKTAFVFQHYNLFANKTALENILEGLMTARKIPKEQAIQIAEQALEKVGLLSYKDYYPSQLSGGQQQRIGIARAIAVKPDLIFFDEPTSALDPELIGDVLGVMKQLAEEGVTMIVVTHEMSFAKDVANHVIFMDGGHIIEEASPKEFFSKPKEDRTRRFLARILSDDSYSVDYIL","888404","For other components see SMu0848 (MSD1); SMu0847 (MSD2) and SMu0846 (SBP1).","amino acid ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several matches in gapped BLAST to amino acid ABC transporter,permease protein: residues 1-250 are 57% similar to the protein inListeria monocytogenes (gi|16804384|).Residues 1-253 are 51% similar to the protein from S.pneumonia (gi|15901310|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0718 (1e-64).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[139-182]T$	ABC_transporter
PF00005	$\"[27-215]T$	ABC_tran
PS00211	$\"[140-154]T$	ABC_TRANSPORTER_1
PS50893	$\"[2-239]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-216]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-248]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-246]T$	PTHR19222
PTHR19222:SF33	$\"[2-246]T$	PTHR19222:SF33
SSF52540	$\"[1-242]T$	SSF52540

","BeTs to 7 clades of COG1126COG name: ABC-type polar amino acid transport system, ATPase componentFunctional Class: EThe phylogenetic pattern of COG1126 is a-----vcEB-Huj----inxNumber of proteins in this genome belonging to this COG is 7","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.5e-36. IPB001140A 16-62 IPB001140B 137-175 IPB001140C 191-220","Residues 1-226 are 20% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 183-223 are 65% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in GLNQ_BACST.Residues 2-226 are 23% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD313900) which is seen in Q9WZT4_THEMA.Residues 184-225 are 61% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174) which is seen in HISP_SALTY.Residues 130-226 are 27% similar to a (ABC TRANSPORTER) protein domain (PD058053) which is seen in O69995_STRCO.Residues 22-229 are 24% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 123-215 are 31% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 138-182 are 51% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD334824) which is seen in YRBF_HAEIN.Residues 1-52 are 51% similar to a (TRANSPORT ATP-BINDING IRON CHELATIN) protein domain (PD351726) which is seen in Y888_HELPY.Residues 184-239 are 50% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD255463) which is seen in Q9ZK44_HELPJ.Residues 140-219 are 35% similar to a (ATP-BINDING) protein domain (PD397028) which is seen in Q53712_STRAT.Residues 184-223 are 67% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9KGD1_BACHD.Residues 97-236 are 23% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 17-64 are 54% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9PP29_CAMJE.Residues 139-179 are 82% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in YA78_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 13:13:12 2002","Thu Jan 3 15:18:18 2002","Sat Oct 12 13:13:12 2002","Thu Jan 3 15:16:52 2002","Thu Jan 3 15:16:52 2002","Thu Jan 3 15:16:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0849 is paralogously related (blast p-value < 1e-3) to SMu0418, SMu0517, SMu1380, SMu0731, SMu0218, SMu1079, SMu0971, SMu1762, SMu1210, SMu1920, SMu1288, SMu1003, SMu0786, SMu0235, SMu1246, SMu1231, SMu1068, SMu1950, SMu0884, SMu1518, SMu1751, SMu0916, SMu1036, SMu1037, SMu1949, SMu0594, SMu0944, SMu1023, SMu1428, SMu0596, SMu1001, SMu0335, SMu0805, SMu0234, SMu0216, SMu0164, SMu0390, SMu1517, SMu1410, SMu0907, SMu1757, SMu0976, SMu0374, SMu1064, SMu0258, SMu0476, SMu1710, SMu1093, SMu0950, SMu1065, SMu1649, SMu1316, SMu0836, SMu0825, SMu0824, SMu0823, SMu1959, SMu1724, SMu0837, SMu1545, SMu0986, SMu0475, SMu0224, SMu1306, SMu0987, SMu1050, SMu0024, SMu0752, SMu1811, SMu0666, SMu1202, SMu0729, and SMu1686 all with ATP-binding capabilities.","Fri Jan 25 15:42:08 2002","Thu Jan 3 15:16:52 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 225 4e-060pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 124 1e-029","SMU.936","","Residues 27 to 215 (E-value = 2e-61) place SMu0849 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Jan 3 15:16:52 2002","24379380","","","","Tue Jan 15 10:58:55 2002","","1","","","SMU.936","" "SMu0850","888612","889544","933","GTGACCGTAAAATCTGTAAAAGTGAAGTCTTATGCAAATATTGCTATCATTAAATATTGGGGTAAGACAAATACTAAAAAGATGATTCCGGCAACCAGTAGTATTTCTTTGACTTTGGAAAATATGTATACGGAAACTAGACTGACTCTTTTAAGAAATGCAGAAGCTGATGAATTTTACATTGATCATATTTTACAAAATGAAGCAGAGCACCGAAAAATCAGTAAGGTTCTGGATTTTTTTAGAAAAGAGACTCCTTTTTTTGTTAAGGTAGAGACTTCCAACAATATGCCAACGGCAGCTGGTTTATCTTCAAGTTCTAGCGGTTTATCAGCTTTGGTTAAGGCTGCCAATATATTCTTTGAAACAAATGCAACTCAGGAAGAACTTGCCCAAATAGCCAAATTTGCTTCAGGTTCTTCTTCGCGTTCTTTTTTTGGACCCTTGACGGCATGGGATAAAGATTCAGGTGAGATTTATCCTGTACCGTCAGATTTAAAGTTAGCTATGATTATGTTGGTTTTGAACGATACCAGAAAACCTATTTCGAGCCGTCAAGGTATGCAGCGTTGTTCAGAGACCTCAACAAATTTTGCTGATTGGATTGCCCAATCTGAAAAGGATTATGTTGCTATGTTGGACTATTTAAAAGCTGCTGACTTTGAAAAAGTCGGCGATTTAACAGAAGCTAATGCTTTAGCTATGCATGCAACAACAAGAACCGCTAATCCTCCTTTTTCTTATTTAACTAAAGCTTCCTACCAAGCTATGGAAAGAGTAAAAGAACTGCGACGGCAAGGTGAAAGGTGTTATTTTACCATGGATGCAGGTCCTAATATCAAAGTTTTGTGTCTCGAGAAAGATTTGGAGCGTCTATCTCGTATTTTTGCGCAAGACTATCAGATTATTGTGTCTAAAACAAAGGAACTTTAA","8.70","3.60","34868","MTVKSVKVKSYANIAIIKYWGKTNTKKMIPATSSISLTLENMYTETRLTLLRNAEADEFYIDHILQNEAEHRKISKVLDFFRKETPFFVKVETSNNMPTAAGLSSSSSGLSALVKAANIFFETNATQEELAQIAKFASGSSSRSFFGPLTAWDKDSGEIYPVPSDLKLAMIMLVLNDTRKPISSRQGMQRCSETSTNFADWIAQSEKDYVAMLDYLKAADFEKVGDLTEANALAMHATTRTANPPFSYLTKASYQAMERVKELRRQGERCYFTMDAGPNIKVLCLEKDLERLSRIFAQDYQIIVSKTKEL","889543","For other 'mva' genes see SMu0163 (mvaK); SMu0851 (mvaK2) and SMu0855 (mvaA).","diphosphomevalonate decarboxylase","Periplasm, Membrane","Several matches in gapped BLAST to diphosphomevalonate decarboxylase:residues 6-310 are 62% similar to the enzyme inS.pneumoniae (gi15902383) and are 61% similar to the protein from S.pyogenes (gi9937401). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1325 (1e-108).","

InterPro
IPR005935
Family

Diphosphomevalonate decarboxylase
PIRSF015950	$\"[4-310]T$	Diphosphomevalonate decarboxylase
PTHR10977	$\"[81-305]T$	DIPHOSPHOMEVALONATE DECARBOXYLASE
TIGR01240	$\"[6-301]T$	mevDPdecarb: diphosphomevalonate decarboxyl

InterPro
IPR006203
Domain

GHMP kinase, ATP-binding region
PS00627	$\"[97-108]?$	GHMP_KINASES_ATP

InterPro
IPR006204
Domain

GHMP kinase
PF00288	$\"[90-148]T$	GHMP_kinases_N

InterPro
IPR013750
Domain

GHMP kinase, C-terminal
PF08544	$\"[212-302]T$	GHMP_kinases_C

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[3-177]T$	no description

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 37-293 are 60% similar to a (DECARBOXYLASE MEVALONATE) protein domain (PD011623) which is seen in Q9FD53_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 16:40:28 2006","Thu Jan 3 15:19:48 2002","Wed Sep 13 16:40:28 2006","Thu Jan 3 15:19:48 2002","","Thu Jan 3 15:19:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0850 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 15:22:01 2002","","No significant hits to the NCBI PDB database.","SMU.937","","Residues 88 to 288 (E-value = 5e-32) place SMu0850 in the GHMP_kinases family which is described as GHMP kinases putative ATP-binding protein (PF00288)","Thu Jan 3 15:19:48 2002","24379381","","","Wilding,E.I., Brown,J.R., Bryant,A.P., Chalker,A.F., Holmes,D.J.,Ingraham,K.A., Iordanescu,S., So,C.Y., Rosenberg,M. and Gwynn,M.N.Identification, evolution, and essentiality of the mevalonatepathway for isopentenyl diphosphate biosynthesis in gram-positivecocciJ. Bacteriol. 182 (15), 4319-4327 (2000)PubMed: 10894743Toth,M.J. and Huwyler,L.Molecular cloning and expression of the cDNAs encoding human andyeast mevalonate pyrophosphate decarboxylaseJ. Biol. Chem. 271 (14), 7895-7898 (1996)PubMed: 8626466Baba,T., Takeuchi,F., Kuroda,M., Yuzawa,H., Aoki,K., Oguchi,A.,Nagai,Y., Iwama,N., Asano,K., Naimi,T., Kuroda,H., Cui,L.,Yamamoto,K. and Hiramatsu,K.Genome and virulence determinants of high virulencecommunity-acquired MRSALancet 359 (9320), 1819-1827 (2002)PubMed: 12044370","","Sat Oct 12 13:20:36 2002","1","","","SMU.937","404" "SMu0851","889546","890544","999","ATGGATAATATCATTCAAGTAAAAACAGGCGGTAAACTATATATTGCTGGTGAATATGCTATCTTAACTCCCAGTCAGTCGGCCATTATTAAAAACATCCCCATTTATATGACAGCTACTATCAAATCTGCCAAAGAAATTTCAATTTGGTCTGATATGTTTGCTTATTGTGTGGGTATGGCGGCTGACTCTAATTATAGCCTGATCCAAGAGACAATTACGGTTTTAGCAAATTTTTTGGGAAAAGAAATTGCTGATTTATCCCCTTTTTCTTTAGAAATTAATGGAGAATTGGGACGCGATGGGAAAAAATTCGGGATTGGTTCTAGTGGTAGTGTTACTATTTTAACCTTAAAAGCACTCTCTCGTTTCTATCAATTGGATTTATCGACAGATACAATCTTTAAGCTGGCTGCCTATACCTTAATTAAGCGTGGTGATAATGGTTCCATGGGAGATTTGGCTTGCATTGCCTATGATAATTTGGTTTATTTTACAGCTTTTGACCGCCAATTAGTAAGGACTTGGATAGTATCTGATGACCTAAGAACTGTTTTAGAGAGGGATTGGGGTTATCGCATTTCAGTCTTATATCCTAAAATCGCTTGCGATTTTCTCGTTGGCTGGACCAAACAACCCTCTATTTCAAATAAGATGGTTAATCTTGTTAAATCTTCAATTACGCCATCCTTTTTAAAAGTCAGTCAGGAAAATGTCGAAAAACTTTCCCAAGGCTTGCTAAATGGTCAAAAAGATGTGATAAAAGAAAGTTTAGCAACTAGCAGCCAGCTCTTAGAAAATCTCAATCCAGCTATCTATACAGAACGTTTACGGCAATTAAAAGCAGCTGAGAAAGGTCTAGATGTCATTGCTAAGAGCAGTGGTTCTGGTGGCGGTGATTGTGGAATTGCTCTTTCTTTTAAAGACAGGGACAGTCACCTTTTAGTGGAACGCTGGCAAAAAGCTGGTATTGAATTGCTTTATCAAGAAAAATTATAG","7.80","1.06","36633","MDNIIQVKTGGKLYIAGEYAILTPSQSAIIKNIPIYMTATIKSAKEISIWSDMFAYCVGMAADSNYSLIQETITVLANFLGKEIADLSPFSLEINGELGRDGKKFGIGSSGSVTILTLKALSRFYQLDLSTDTIFKLAAYTLIKRGDNGSMGDLACIAYDNLVYFTAFDRQLVRTWIVSDDLRTVLERDWGYRISVLYPKIACDFLVGWTKQPSISNKMVNLVKSSITPSFLKVSQENVEKLSQGLLNGQKDVIKESLATSSQLLENLNPAIYTERLRQLKAAEKGLDVIAKSSGSGGGDCGIALSFKDRDSHLLVERWQKAGIELLYQEKL","890543","For other 'mva' genes see SMu0163 (mvaK); SMu0850 (mvaD) and SMu0855 (mvaA).","phosphomevalonate kinase","Cytoplasm, Membrane","Several matches in gapped BLAST to phosphomevalonate kinase: residues 7-331 are 55% similar to the enzyme in S.pyogenes (gi|15674903|).Residues 4-332 are 52% similar tothe protein from S.pneumoniae (gi|15902384|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1324 (1e-100).","

InterPro
IPR005917
Family

Gram positive phosphomevalonate kinase
PIRSF500057	$\"[4-332]T$	PMK_bact
TIGR01220	$\"[5-331]T$	Pmev_kin_Gr_pos

InterPro
IPR006204
Domain

GHMP kinase
PF00288	$\"[91-161]T$	GHMP_kinases_N

InterPro
IPR010916
Domain

TonB box, N-terminal
PS00430	$\"[1-78]?$	TONB_DEPENDENT_REC_1

InterPro
IPR012197
Family

Mevalonate kinase/phosphomevalonate kinase
PIRSF000546	$\"[4-332]T$	MVK_PMK

InterPro
IPR013750
Domain

GHMP kinase, C-terminal
PF08544	$\"[242-325]T$	GHMP_kinases_C

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[28-128]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.890	$\"[198-330]T$	G3DSA:3.30.70.890
SSF54211	$\"[4-197]T$	SSF54211
SSF55060	$\"[198-332]T$	SSF55060

","BeTs to 4 clades of COG1577COG name: Mevalonate kinaseFunctional Class: IThe phylogenetic pattern of COG1577 is amtky-----------o----Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 246-307 are 58% similar to a (KINASE GALACTOSE GALACTOKINASE) protein domain (PD002375) which is seen in Q9FD57_STRPY.Residues 4-138 are 33% similar to a (KINASE PHOSPHOMEVALONATE PROTEOME) protein domain (PD401486) which is seen in Q9FD62_ENTFC.Residues 4-138 are 33% similar to a (KINASE GALACTOSE GALACTOKINASE) protein domain (PD017586) which is seen in Q9FD72_STAEP.Residues 150-319 are 49% similar to a (KINASE PHOSPHOMEVALONATE) protein domain (PD263891) which is seen in Q9FD52_STRPN.Residues 7-149 are 60% similar to a (KINASE PHOSPHOMEVALONATE) protein domain (PD407697) which is seen in Q9FD57_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 08:12:48 2002","Thu Jan 3 15:29:08 2002","Tue Oct 29 08:12:48 2002","Thu Jan 3 15:29:08 2002","","Thu Jan 3 15:29:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0851 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 15:30:33 2002","","No significant hits to the NCBI PDB database.","SMU.938","","Residues 89 to 308 (E-value = 2.5e-20) place SMu0851 in the GHMP_kinases family which is described as GHMP kinases putative ATP-binding protein (PF00288)","Thu Jan 3 15:29:08 2002","24379382","","","Wilding,E.I., Brown,J.R., Bryant,A.P., Chalker,A.F., Holmes,D.J.,Ingraham,K.A., Iordanescu,S., So,C.Y., Rosenberg,M. and Gwynn,M.N.Identification, evolution, and essentiality of the mevalonatepathway for isopentenyl diphosphate biosynthesis in gram-positivecocciJ. Bacteriol. 182 (15), 4319-4327 (2000)PubMed: 10894743Takagi,M., Kuzuyama,T., Takahashi,S. and Seto,H.A gene cluster for the mevalonate pathway from Streptomyces sp.Strain CL190J. Bacteriol. 182 (15), 4153-4157 (2000)PubMed: 10894721","","Thu Jan 3 15:32:37 2002","1","","","SMU.938","579" "SMu0852","890554","891549","996","ATGACAAATAGAAAAGATGATCATATAAAATATGCCTTAGACTATCGTTCGCCATATAATAGTTTCGATGACATAGAACTCATTCATCATTCTTTACCAGATTATGATTTAGCCGAGATTGATTTGTCTACACATTTTGCTGGTCAGGATTTTGATTTTCCTTTTTATATCAACGCTATGACAGGCGGAAGCCAAAAAGGGAAAGAAGTTAATGAAAAATTAGCTCAGGTAGCGGACACCTGTGGTCTTCTTTTTGTAACAGGTTCTTACAGCACAGCTCTTAAAAATCCAGACGATACTTCTTATCAGGTAAAAAAATCCAGACCTCATTTATTACTAGCAACCAATATCGGCCTTGACAAACCTTATCAGGCTGGCTTACAGGCAGTTAGGGATTTACAGCCTTTATTTCTTCAAGTTCATATTAATCTTATGCAAGAGCTCCTTATGCCAGAGGGGGAACGCGAATTTAGGTCTTGGAAGAAACATTTATCTGACTATGCGAAGAAACTACAACTTCCTTTTATTTTAAAAGAAGTTGGTTTTGGTATGGACGTTAAAACAATCCAAACTGCTATTGACCTAGGGGTTAAAACTGTCGATATTTCTGGCCGAGGCGGAACTAGTTTTGCTTATATCGAAAATAGACGTGGCGGAAATCGTTCTTATCTTAATCAATGGGGACAAACCACAGCGCAAGTTCTATTAAATGCTCAGCCGCTTATGGATAAGGTAGAAATCCTGGCTAGCGGCGGGATTCGTCATCCATTGGACATAATAAAAGCTTTGGTCCTTGGAGCCAAAGCGGTCGGTTTATCTCGAACGATGTTAGAATTAGTTGAACAGCATTCTGTTCATGAAGTCATTGCTATTGTAAATGGTTGGAAAGAAGATTTGCGCCTGATCATGTGCGCCCTTAACTGTCAAACGATTGCAGAACTTCGAAATGTTGACTATCTTTTATATGGGCGCTTAAGAGAAGGACAGAGACAATAA","6.90","-0.72","37296","MTNRKDDHIKYALDYRSPYNSFDDIELIHHSLPDYDLAEIDLSTHFAGQDFDFPFYINAMTGGSQKGKEVNEKLAQVADTCGLLFVTGSYSTALKNPDDTSYQVKKSRPHLLLATNIGLDKPYQAGLQAVRDLQPLFLQVHINLMQELLMPEGEREFRSWKKHLSDYAKKLQLPFILKEVGFGMDVKTIQTAIDLGVKTVDISGRGGTSFAYIENRRGGNRSYLNQWGQTTAQVLLNAQPLMDKVEILASGGIRHPLDIIKALVLGAKAVGLSRTMLELVEQHSVHEVIAIVNGWKEDLRLIMCALNCQTIAELRNVDYLLYGRLREGQRQ","891548","","isopentenyl-diphosphate delta-isomerase","Cytoplasm","Matches in gapped BLAST to FMN-dependent dehydrogenase family protein and to isopentenyl diphosphate isomerase: residues 2-331 are 70% similar to the enzyme in S.pneumoniae (gi15900307). Residues 4-314 are 40% similar to isopentenyl diphosphate isomerase in S.aureus (gi13878549).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1323 (1e-136).","

InterPro
IPR002932
Domain

Glutamate synthase, central-C
PF01645	$\"[232-277]T$	Glu_synthase

InterPro
IPR011179
Family

Isopentenyl-diphosphate delta-isomerase, FMN-dependent
PIRSF003314	$\"[1-330]T$	IPP_isomerase
PTHR10578:SF3	$\"[6-324]T$	IPdP_isomerase
TIGR02151	$\"[3-323]T$	IPP_isom_2

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[18-327]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR10578	$\"[6-324]T$	PTHR10578
SSF51395	$\"[18-327]T$	SSF51395

","BeTs to 12 clades of COG1304COG name: L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenasesFunctional Class: CThe phylogenetic pattern of COG1304 is Amtky--cebRh----ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB000262 (FMN-dependent alpha-hydroxy acid dehydrogenases) with a combined E-value of 4.4e-08. IPB000262B 48-95 IPB000262F 243-295","Residues 159-314 are 40% similar to a (DEHYDROGENASE OXIDASE OXIDOREDUCTASE BIOSYNTHESIS FMN) protein domain (PD000662) which is seen in IDI2_STAAU.Residues 201-241 are 55% similar to a (ISOMERASE IPP NADP) protein domain (PD377202) which is seen in IDI2_STRC1.Residues 4-157 are 41% similar to a (ISOMERASE IPP NADP) protein domain (PD007378) which is seen in IDI2_STAAU.Residues 201-313 are 43% similar to a (ISOMERASE IPP NADP) protein domain (PD224777) which is seen in IDI2_KITGR.Residues 171-231 are 41% similar to a (ISOMERASE IPP NADP) protein domain (PD270587) which is seen in IDI2_RICPR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 21 08:30:19 2002","Wed Sep 13 16:34:20 2006","Wed Sep 13 16:32:30 2006","Thu Jan 3 16:34:31 2002","Thu Jan 3 16:34:31 2002","Thu Jan 3 16:34:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0852 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 16:34:58 2002","Wed Sep 13 16:32:30 2006","pdb1QCWA Chain A, Flavocytochrome B2, Arg289lys Mutant >gi51... 67 3e-012pdb1LCOA Chain A, Mol_id: 1; Molecule: L-Lactate Dehydrogenas... 66 5e-012pdb1LTDA Chain A, Flavocytochrome B2 (E.C.1.1.2.3) Complexed ... 66 5e-012","SMU.939","","Residues 10 to 322 (E-value = 1.5e-05) place SMu0852 in the FMN_dh family which is described as FMN-dependent dehydrogenase (PF01070)","Thu Jan 3 16:34:31 2002","24379383","","","Kaneda,K., Kuzuyama,T., Takagi,M., Hayakawa,Y. and Seto,H.An unusual isopentenyl diphosphate isomerase found in themevalonate pathway gene cluster from Streptomyces sp. strain CL190Proc. Natl. Acad. Sci. U.S.A. 98 (3), 932-937 (2001)PubMed: 11158573","","Thu Mar 21 08:30:19 2002","1","","","SMU.939","403" "SMu0853","892288","891632","657","ATGAGTCCAACACAAACTCTGAAACTAAGTAAACAATTGAGTTTTGGCGAAGAGGTTGCTAACAGTGTGACACATGCTGTTGGTGCAGCTATTATGCTTGTTCTGCTCCCTATTTCCGCCATTTACAGTTATCAACATTACGGAATAGCCGCTGCAATCGGAATGTCCATTTTTGTCATCAGTCTCTTTTTGATGTTTTTGTCATCAACTGTTTATCATGCTATGACTTATGATTCACCACAAAAATATGTTCTTCGTATTATTGATCACAGTATGATTTATATTGCTATTGCAGGAAGTTATACACCAGTTGCACTTTCACTGGTCGGAGGTTGGTTAGGCTACCTTATTATTGTTCTTCAGTGGGGCACTACTATTTTTGGTATTTTATATAAGATTTTTGCTAAGAAGATTAATGACAAATTCAGTCTTTTCCTTTATTTATTGATGGGATGGCTGGTTATCTTTATTATTCCAGCTATTGTCAGCAAGACTGGTCTAGCTTTTTGGCTTTTAATGTTAGGCGGTGGCTTATCTTATACTGTTGGAGCTTTCTTCTACGCTAAAAAGAAACCTTATTTTCACATGATTTGGCATCTCTTTATTTTACTGGCTTCTGCTTTGCAATATATCGCTATTGTCTACTATATGCTATAA","10.30","8.42","24404","MSPTQTLKLSKQLSFGEEVANSVTHAVGAAIMLVLLPISAIYSYQHYGIAAAIGMSIFVISLFLMFLSSTVYHAMTYDSPQKYVLRIIDHSMIYIAIAGSYTPVALSLVGGWLGYLIIVLQWGTTIFGILYKIFAKKINDKFSLFLYLLMGWLVIFIIPAIVSKTGLAFWLLMLGGGLSYTVGAFFYAKKKPYFHMIWHLFILLASALQYIAIVYYML","891637","","hemolysin III-related protein","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to hemolysin: residues 6-217 are 79% similar to the enzyme in S.pneumoniae (gi15903363).Residues 5-218 are 78% similar to the protein from S.pyogenes (gi15675135).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1319 (8e-98).","

InterPro
IPR004254
Family

Hly-III related proteins
PTHR20855	$\"[17-218]T$	HlyIII_related
PF03006	$\"[13-210]T$	HlyIII

InterPro
IPR005744
Family

HylII
PTHR20855:SF3	$\"[17-218]T$	HylIII
TIGR01065	$\"[17-217]T$	hlyIII

","BeTs to 5 clades of COG1272COG name: Predicted membrane proteins, hemolysin III homologsFunctional Class: RThe phylogenetic pattern of COG1272 is ----Y---ebr-----ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 18-216 are 39% similar to a (HEMOLYSIN PROTEOME COMPLETE TRANSMEMBRANE) protein domain (PD150356) which is seen in HLY3_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 21 08:31:45 2002","Wed Aug 30 16:43:55 2006","Wed Aug 30 16:41:44 2006","Thu Jan 3 16:45:35 2002","","Thu Jan 3 16:45:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0853 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 16:57:23 2002","","No significant hits to the NCBI PDB database.","SMU.940c","","Residues 13 to 214 (E-value = 2.9e-71) place SMu0853 in the UPF0073 family which is described as Uncharacterised protein family (Hly-III / UPF0073) (PF03006)","Thu Jan 3 16:45:35 2002","24379384","","","Baida,G.E. and Kuzmin,N.P.Cloning and primary structure of a new hemolysin gene from Bacillus cereusBiochim. Biophys. Acta 1264 (2), 151-154 (1995)PubMed: 7495855","","Thu Jan 3 16:57:23 2002","1","","","SMU.940c","578" "SMu0854","892598","892257","342","ATGATTAATAATTATGTCAAACATGGTCATATTGAAAAGCCAATCAAGAAAAAATATAATCGAAAACAGGTCGCTCGTTTGATTGTTATTACTGCTCTCAAAAATGTCTTCTCTATCCAAGAGATTAGCCAGACTTTGACCGTTTTAACAGCAAATAACTCTTCAAAAAACCTTTATAATGACTTTGTAACCTGTATGAACACCGATGAAAGACAAGATATTGCCCCTGTAGTGGTATCAGCTTGTCAAACTCTAAAACTTTATCTGCAAACACATCAGCTTGTCTTAGAACTAGAAAGAAGTGATATCAATGAGTCCAACACAAACTCTGAAACTAAGTAA","9.30","3.61","12934","MINNYVKHGHIEKPIKKKYNRKQVARLIVITALKNVFSIQEISQTLTVLTANNSSKNLYNDFVTCMNTDERQDIAPVVVSACQTLKLYLQTHQLVLELERSDINESNTNSETK","892262","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical protein: residues 1-98 are 54% similar to the protein in S.pyogenes (gi|15675136|). Residues 1-95 are 54% similar to the protein from S.pneumoniae (gi|15903362|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1318 (6e-36).","

InterPro
IPR014975
Family

Domain of unknown function DUF1836
PF08876	$\"[1-97]T$	DUF1836

InterPro
IPR002202
Domain

Hydroxymethylglutaryl-coenzyme A reductase
PR00071	$\"[55-76]T$ $\"[82-102]T$ $\"[174-192]T$	HMGCOARDTASE
G3DSA:3.90.770.10	$\"[6-376]T$	HMG-CoA_red
PTHR10572	$\"[57-117]T$	HMG-CoA_red
PS50065	$\"[53-385]T$	HMG_COA_REDUCTASE_4

InterPro
IPR004553
Family

Hydroxymethylglutaryl-CoA reductase, degradative
TIGR00532	$\"[1-387]T$	HMG_CoA_R_NAD

InterPro
IPR009023
Domain

Hydroxymethylglutaryl-CoA reductase, NAD-binding
SSF55035	$\"[116-220]T$	HMG_CoA_NAD_bind

InterPro
IPR009029
Domain

Hydroxymethylglutaryl-CoA reductase, substrate-binding
SSF56542	$\"[9-427]T$	HMG_CoA_sub_bind

","BeTs to 6 clades of COG1257COG name: Hydroxymethylglutaryl-CoA reductaseFunctional Class: IThe phylogenetic pattern of COG1257 is amtkY-----------o----Number of proteins in this genome belonging to this COG is 1","***** IPB002202 (Hydroxymethylglutaryl-coenzyme A reductase) with a combined E-value of 1e-08. IPB002202A 46-89 IPB002202B 169-195 IPB002202D 251-298 IPB002202E 347-387","Residues 117-427 are 66% similar to a (REDUCTASE HMG-COA) protein domain (PD024448) which is seen in Q9FD55_STRPN.Residues 15-115 are 54% similar to a (REDUCTASE HMG-COA) protein domain (PD375733) which is seen in Q9FD55_STRPN.Residues 52-110 are 61% similar to a (REDUCTASE OXIDOREDUCTASE) protein domain (PD001154) which is seen in HMDH_ARCFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 16:25:42 2006","Thu Jan 3 17:04:22 2002","Wed Sep 13 16:25:42 2006","Thu Jan 3 17:03:52 2002","Thu Jan 3 17:03:52 2002","Thu Jan 3 17:03:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0855 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 3 17:04:22 2002","Wed Sep 13 16:25:42 2006","pdb1QAXA Chain A, Ternary Complex Of Pseudomonas Mevalonii Hm... 315 8e-087pdb1DQ8A Chain A, Complex Of The Catalytic Portion Of Human H... 63 6e-011","SMU.942c","","Residues 14 to 418 (E-value = 1.4e-16) place SMu0855 in the HMG-CoA_red family which is described as Hydroxymethylglutaryl-coenzyme A reductase (PF00368)","Thu Jan 3 17:03:52 2002","","","","Wilding,E.I., Brown,J.R., Bryant,A.P., Chalker,A.F., Holmes,D.J.,Ingraham,K.A., Iordanescu,S., So,C.Y., Rosenberg,M. and Gwynn,M.N.Identification, evolution, and essentiality of the mevalonatepathway for isopentenyl diphosphate biosynthesis in gram-positivecocciJ. Bacteriol. 182 (15), 4319-4327 (2000)PubMed: 10894743","","Thu Jan 3 17:05:54 2002","1","","","SMU.942c","402" "SMu0856","895306","894131","1176","ATGAGAATTGGGATTGATAAAATTGGTTTTACAAGCAGCCAATATGTCCTGAATATGAAAGATTTAGCTGAGGCCCGTGGCGAAGATCCCCAAAAATTCAGTAAAGGACTTTTGCTGAATGCTCTTAGCATCGCTCCTATTACCGACGACGTTGTCACCCTAGCAGCCGGATCAGCCAATGAAATTCTGACTGCAGAGGATAAAGAAAAAATTGATATGGTCATTTTAGCTACCGAATCCAGCGTTGATCAAAGTAAGGCTGGAGCTGTTTATGTGCATTCCTTATTAGGTATTCAGCCTTTTGCGCGCAGCTTTGAGATGAAAGAGGCATGCTACAGTGCTACTGCAGCTCTCAACTATGCTAAACTGCATGTTGAAAAACATCCTGACACGCGTGTGCTTGTTCTTGCTAGCGATATTGCCAAATACGGAATTGGAACTCCCGGAGAATCTACTCAAGGAGCCGGCAGCATTGCCATGCTGGTCAAAAAAGATCCCCGTATTCTTATTCTTCATGATGAGACCTTAGCTCAGACACGTGATATTATGGATTTTTGGCGGCCAAATTATACAACAACACCTTATGTTAATGGTATGTATTCTACCAAACAATATTTGGATATGCTGAAAACGACTTGGGCAGAATATCAAAAACGTTTTGATGTTTCTTTAACTGATTTTGCAGCTTTTTGCTTTCATCTTCCTTTTCCTAAACTAGCTCTTAAAGGCTTTAACAAAATCATGGATAAGCAAGTCCCATCTGATTTGCAGGAAAAACTTAAGGTGAATTTTGAAGCTTCCATTCTTTATAGCAAGCAAATCGGAAATATCTATACAGGTTCACTCTTTTTAGGACTCCTTTCTCTTTTGGAAAATAGTCAAAATCTTGTGGCTGGTGATAAGATTGCTCTTTTTAGCTATGGTAGCGGGGCTGTTGCTGAAATTTTCACAGGAACACTGGTTAAAGGTTTCAAAGAACAGCTACAGACTAATCGTCTTGACAAACTCAAAAGACGGACTCCCTTATCTGTTGAGAATTACGAGAAAATCTTTTTTGAAGAGGCTCAACTTGATGACAAAGGAAATGCTTCTTTCAAAGAATATCAGACAGGACCTTTTGCCTTAAAAGAAATCCTTGAACACCAAAGAATCTATGGTAAAGTCAATGAATCCTAA","6.50","-1.62","43572","MRIGIDKIGFTSSQYVLNMKDLAEARGEDPQKFSKGLLLNALSIAPITDDVVTLAAGSANEILTAEDKEKIDMVILATESSVDQSKAGAVYVHSLLGIQPFARSFEMKEACYSATAALNYAKLHVEKHPDTRVLVLASDIAKYGIGTPGESTQGAGSIAMLVKKDPRILILHDETLAQTRDIMDFWRPNYTTTPYVNGMYSTKQYLDMLKTTWAEYQKRFDVSLTDFAAFCFHLPFPKLALKGFNKIMDKQVPSDLQEKLKVNFEASILYSKQIGNIYTGSLFLGLLSLLENSQNLVAGDKIALFSYGSGAVAEIFTGTLVKGFKEQLQTNRLDKLKRRTPLSVENYEKIFFEEAQLDDKGNASFKEYQTGPFALKEILEHQRIYGKVNES","894136","","hydroxymethylglutaryl-CoA synthase","Cytoplasm, Membrane","Several matches in gapped BLAST tohydroxymethylglutaryl-CoA synthase: residues 1-390 are 64% similar to the protein in S.pneumoniae (gi15901560). Residues 1-385 are 65% similar to the protein from S.pyogenes(gi9937397). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1316 (1e-156).","

InterPro
IPR008260
Family

Hydroxymethylglutaryl-coenzyme A synthase
PIRSF001368	$\"[1-389]T$	HMG_coA_syn

InterPro
IPR011554
Family

Hydroxymethylglutaryl-coenzyme A synthase, prokaryotic
PIRSF500082	$\"[1-389]T$	HMG_CoA_syn_bac
TIGR01835	$\"[3-385]T$	HMG-CoA-S_prok

InterPro
IPR013528
Domain

Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
PF01154	$\"[1-167]T$	HMG_CoA_synt_N

InterPro
IPR013746
Domain

Hydroxymethylglutaryl-coenzyme A synthase C-terminal
PF08540	$\"[170-388]T$	HMG_CoA_synt_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.47.10	$\"[67-173]T$	G3DSA:3.40.47.10
PTHR11877	$\"[13-316]T$	PTHR11877
SSF53901	$\"[2-167]T$ $\"[168-389]T$	SSF53901

","BeTs to 10 clades of COG0332COG name: 3-oxoacyl-[acyl-carrier-protein] synthase IIIFunctional Class: IThe phylogenetic pattern of COG0332 is Amtkyq-ceBRhuj--o-inxNumber of proteins in this genome belonging to this COG is 2","***** IPB000590 (Hydroxymethylglutaryl-coenzyme A synthase) with a combined E-value of 6.7e-13. IPB000590D 110-141 IPB000590E 158-211 IPB000590F 224-252 IPB000590G 252-306","Residues 66-170 are 33% similar to a (SYNTHASE CHALCONE TRANSFERASE ACYLTRANSFERASE) protein domain (PD000453) which is seen in CHSY_DIACA.Residues 3-279 are 68% similar to a (SYNTHASE HMG-COA PROTEOME COMPLETE) protein domain (PD004407) which is seen in Q9FD56_STRPN.Residues 265-317 are 56% similar to a (SYNTHASE HMG-COA) protein domain (PD246321) which is seen in Q9FD61_STRPY.Residues 38-253 are 71% similar to a (SYNTHASE COENZYME BIOSYNTHESIS) protein domain (PD005059) which is seen in Q9FD61_STRPY.Residues 336-385 are 62% similar to a (SYNTHASE HMG-COA) protein domain (PD347750) which is seen in Q9FD61_STRPY.Residues 296-332 are 64% similar to a (SYNTHASE HMG-COA COMPLETE) protein domain (PD388135) which is seen in Q9FD56_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 13:28:09 2002","Fri Jan 4 10:55:30 2002","Wed Sep 13 16:11:26 2006","Fri Jan 4 10:55:30 2002","Fri Jan 4 10:55:30 2002","Fri Jan 4 10:55:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0856 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 4 10:57:44 2002","","No significant hits to the NCBI PDB database.","SMU.943c","","Residues 3 to 388 (E-value = 3.4e-11) place SMu0856 in the HMG_CoA_synt family which is described as Hydroxymethylglutaryl-coenzyme A synthase (PF01154)","Fri Jan 4 10:55:30 2002","24379387","","","Wilding,E.I., Brown,J.R., Bryant,A.P., Chalker,A.F., Holmes,D.J.,Ingraham,K.A., Iordanescu,S., So,C.Y., Rosenberg,M. and Gwynn,M.N.Identification, evolution, and essentiality of the mevalonatepathway for isopentenyl diphosphate biosynthesis in gram-positivecocciJ. Bacteriol. 182 (15), 4319-4327 (2000)PubMed: 10894743","","Fri Jan 4 10:57:44 2002","1","","","SMU.943c","401" "SMu0857","895514","896353","840","ATGTCTAAGGCAGATTTTATTTTCAAAAAAAATATAAAAAAAATCTTAACTGATGGTGTCTGGAGCGAACAGGCTCGTCCTAAATATAAAAATGGCAAGACAGCCAATTCTAAATATATTACAGGCGCTTTTGCAGAATATGACCTTGCAAAAGGAGAATTTCCTATCACAACCCTTCGTCCGATTGCTATCAAGTCAGCTATCAAGGAAGTATTCTGGATCTATCAGGATCAGACCAACGAATTAGCCATCTTAAATGATAAGTACGGTGTTAGGTATTGGAATGATTGGGAAGTCAAGCAAACAGGAACCATCGGAGAACGTTATGGTGCCATTGTTAAGAAACATGATATTATGAATAAAATTCTCAAACAATTGGAAGAAAATCCTTGGAATCGACGCAATGTCATCTCTCTTTGGGATTATGAAGCCTTTGAAAAAACAGAAGGTCTCCTACCTTGTGCCTTTCAAATCATGTTCGATGTTCGTCGTGTGAAAGGCGAAATTTATTTAGATGCTACCTTAACACAGCGCTCCAACGATATGCTGGTTGCTCACCATATCAACGCCATGCAATATGTCGCTTTGCAGATGATGATCGCCAAACACTTTGGTTGGAAGGTTGGTAAATTCTTCTATTTTGTCAATAATCTCCATATTTATGATAATCAATTTGAACAAGCAGAGGAATTATTGCGGAGAGAGCCAGTGGTTTGTCAACCGCATTTGGTATTGAATGTCCCAAATAAAACTAATTTCTTTGATATTAAACCTGAAGATTTTGAATTATTGGATTATGAACCGGTTAAACCACAATTAAAATTTGATTTAGCTATTTAA","8.60","3.36","32817","MSKADFIFKKNIKKILTDGVWSEQARPKYKNGKTANSKYITGAFAEYDLAKGEFPITTLRPIAIKSAIKEVFWIYQDQTNELAILNDKYGVRYWNDWEVKQTGTIGERYGAIVKKHDIMNKILKQLEENPWNRRNVISLWDYEAFEKTEGLLPCAFQIMFDVRRVKGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFVNNLHIYDNQFEQAEELLRREPVVCQPHLVLNVPNKTNFFDIKPEDFELLDYEPVKPQLKFDLAI","896352","","thymidylate synthase","Cytoplasm","Several matches in gapped BLAST to thymidylate synthase: residues 1-279 are 84% similar to the protein in S.pneumoniae (gi|15900570|)and are 81% similar to the protein from S.pyogenes(gi|15674907|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1315 (1e-143).","

InterPro
IPR000398
Domain

Thymidylate synthase, C-terminal
PD001180	$\"[192-279]T$	Thymidylat_synth
PR00108	$\"[54-75]T$ $\"[122-141]T$ $\"[171-197]T$ $\"[209-226]T$	THYMDSNTHASE
G3DSA:3.30.572.10	$\"[2-279]T$	Thymidylat_synth_C
PF00303	$\"[3-279]T$	Thymidylat_synt
PS00091	$\"[133-162]T$	THYMIDYLATE_SYNTHASE

InterPro
IPR014370
Family

Thymidylate synthase
PIRSF000387	$\"[5-279]T$	TSase

noIPR
unintegrated

unintegrated
PTHR11549	$\"[97-279]T$	PTHR11549
PTHR11549:SF2	$\"[97-279]T$	PTHR11549:SF2
SSF55831	$\"[2-279]T$	SSF55831

","BeTs to 8 clades of COG0207COG name: Thymidylate synthaseFunctional Class: FThe phylogenetic pattern of COG0207 is amt-y---eBrh--gp-----Number of proteins in this genome belonging to this COG is 1","***** IPB000398 (Thymidylate synthase) with a combined E-value of 1.3e-18. IPB000398B 54-80 IPB000398D 116-157 IPB000398E 163-217 IPB000398F 255-278","Residues 4-279 are 76% similar to a (SYNTHASE THYMIDYLATE TRANSFERASE) protein domain (PD001180) which is seen in TYSY_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 13:31:56 2002","Fri Jan 4 11:14:57 2002","Sat Oct 12 13:31:56 2002","Fri Jan 4 11:14:36 2002","Fri Jan 4 11:14:36 2002","Fri Jan 4 11:14:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0857 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 4 11:14:57 2002","Fri Jan 4 11:14:36 2002","pdb|1B02|A Chain A, Crystal Structure Of Thymidylate Synthase A... 130 2e-031pdb|1BKP|B Chain B, Thermostable Thymidylate Synthase A From Ba... 128 7e-031pdb|2TSC|A Chain A, Thymidylate Synthase (E.C.2.1.1.45) Complex... 98 2e-021","SMU.944","","Residues 5 to 279 (E-value = 3.7e-103) place SMu0857 in the Thymidylat_synt family which is described as Thymidylate synthase (PF00303)","Fri Jan 4 11:14:36 2002","24379388","","","","","","1","","","SMU.944","400" "SMu0858","896470","897249","780","GTGTCTAGAAAAGCAAGCAATATCTGGGATAATTTTAAATGGCTGTGGCAAGAAGGTAAAAAATTAGGCTTTTGGGGGATATTACAAGCGCTATGGGAGGATTTGGTTAAAAATAGGAGCCTGTCGCAGTGGCTATACCTTTTAGCTCTTAGTTTTCCAACACTGGTTTTAGAATTTATCGGTGGAACACGGCACATTGCTGGTTTTGCGGCAGCACTGACAGGAATTCTATGTGTTATCTTTGTTGCTGAGGGGCGTATCAGTAATTATTTCATCGGTTTTATTCATGAAATGCTCTATCTTTATCTCAGTTTTGAAAATATGTATTATGGTGAAGTTTTAACAACCTTATTTTTCACTGTCATGCAATTTGTCGGTGCTTATTATTGGTTGATTGGACATCGTGAAGGACAGGGAAAGAAAGTTGAAGTAAAGGATGTTAAATCACGAAAACTGACACCCCTAGGCTGGTTGAAATCACTTGGAATTACAATTATTGTTTGGTTAGTTTTTGGCTTTATTTATCGATCAATCGGTTCGCATCGCCCTTTTTGGGATAGTTCAACAGATGGTACCAATTGGAGCGGTCAGTTTCTTCAAACAGGCATGTACAGTGAACAATGGCTCTTTTGGATTGCGACCAATGTTCTCAGCATTTTTCTTTGGTGGGGTGCAGAACCACATGTTATGCTCATGTATATTATTTATATGATTAATAGTATTGTTGGTTGGGTAAAATGGGAACGTGATCTTAGAATAACTCAAGAACAGTTAGCTTAA","9.60","4.15","30291","MSRKASNIWDNFKWLWQEGKKLGFWGILQALWEDLVKNRSLSQWLYLLALSFPTLVLEFIGGTRHIAGFAAALTGILCVIFVAEGRISNYFIGFIHEMLYLYLSFENMYYGEVLTTLFFTVMQFVGAYYWLIGHREGQGKKVEVKDVKSRKLTPLGWLKSLGITIIVWLVFGFIYRSIGSHRPFWDSSTDGTNWSGQFLQTGMYSEQWLFWIATNVLSIFLWWGAEPHVMLMYIIYMINSIVGWVKWERDLRITQEQLA","897248","This protein is involved in the transport of small molecules:Nucleosides, purines, pyrimidines [gi:15800460].","transporter for NMN","Membrane, Cytoplasm","Limited matches in gapped BLAST to possible nicotinamide mononucleotide transporter: residues 22-249 are 50% similar to the protein in S.pneumoniae (gi|15901687|). Residues 71-256are 24% similar to the protein from Lactococcus lactis subsp. lactis (gi|15672860|).SMu0858 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006419
Family

Nicotinamide mononucleotide transporter PnuC
PF04973	$\"[41-217]T$	NMN_transporter
TIGR01528	$\"[64-253]T$	NMN_trans_PnuC: nicotinamide mononucleotide

noIPR
unintegrated

unintegrated
tmhmm	$\"[21-39]?$ $\"[45-63]?$ $\"[68-90]?$ $\"[109-131]?$ $\"[155-175]?$ $\"[207-225]?$	transmembrane_regions

","BeTs to 3 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 74-180 are 45% similar to a (PROTEOME COMPLETE MONONUCLEOTIDE) protein domain (PD032505) which is seen in Q9K2Z5_STRPN.Residues 71-256 are 24% similar to a (PROTEOME COMPLETE MONONUCLEOTIDE) protein domain (PD400890) which is seen in Q9CH61_LACLA.Residues 1-64 are 42% similar to a (DOMAIN OF UNKNO N) protein domain (PD273058) which is seen in Q9K2Z5_STRPN.Residues 204-249 are 44% similar to a (PROTEOME COMPLETE PM1838) protein domain (PD384916) which is seen in Q9CK00_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 08:26:17 2002","Sat Oct 12 13:35:29 2002","Sat Oct 12 13:35:29 2002","Mon Jan 7 08:31:05 2002","","Mon Jan 7 08:31:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0858 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 08:34:10 2002","","No significant hits to the NCBI PDB database.","SMU.946","","Residues 41 to 217 (E-value = 7.6e-24) place SMu0858 in the NMN_transporter family which is described as Nicotinamide mononucleotide transporter (PF04973)","Mon Jan 7 08:31:05 2002","24379389","","","Flachmann,R., Kunz,N., Seifert,J., Gutlich,M., Wientjes,F.J.,Laufer,A. and Gassen,H.G.Molecular biology of pyridine nucleotide biosynthesis inEscherichia coli. Cloning and characterization of quinolinatesynthesis genes nadA and nadBEur. J. Biochem. 175 (2), 221-228 (1988)PubMed: 2841129Foster,J.W., Park,Y.K., Penfound,T., Fenger,T. and Spector,M.P.Regulation of NAD metabolism in Salmonella typhimurium: molecularsequence analysis of the bifunctional nadR regulator and thenadA-pnuC operonJ. Bacteriol. 172 (8), 4187-4196 (1990)PubMed: 2198247","","Mon Jan 7 08:40:12 2002","1","","","SMU.946","" "SMu0859","897334","897846","513","ATGAACAATAAGCGAGAAAAGAAAATTGTTGCCATTTGGGCAGAAGATGACAGACACTTAATTGGAGTTAAAGGCAGTCTTCCTTGGCATTTACCCAAAGAGTTGAACCATTTTAAAGAGATGACCATGGGGCAAGCTCTATTGATGGGACGCGTTACCTTTGATGGTATGAACCGCCGTGTGTTACCTGGACGTGACACCTTGATTTTAACTCATGATCCACAGTTTAAGGCAGAAGGTGTAAGCATTGTCCACAGTGTCCCAGAAGCTCTTTCTTGGTACAGGCAGCAAGACAAAAGTTTATTTATTGTTGGTGGTGCATCTATTTATAAAGCTTTTGAAAGTTATTATGATAAAATAATAAAAACATCAGTTCATGGACAGTTTGAAGGAGATACTTATTTTCCTCTAAGAGATTTTTCTAGTTTTCAGGAAATTTCTCAAGCTTTTTTTGAAAAAGATGAAAATAACAGTCATGACTTTACTGTTACTGTACTTGAGAAAAAGGAATGA","6.90","-0.32","19655","MNNKREKKIVAIWAEDDRHLIGVKGSLPWHLPKELNHFKEMTMGQALLMGRVTFDGMNRRVLPGRDTLILTHDPQFKAEGVSIVHSVPEALSWYRQQDKSLFIVGGASIYKAFESYYDKIIKTSVHGQFEGDTYFPLRDFSSFQEISQAFFEKDENNSHDFTVTVLEKKE","897845","","dihydrofolate reductase","Cytoplasm","Several matches in gapped BLAST to dihydrofolate reductase: residues 7-170 are 54% similar to the enzyme in S.pneumoniae (gi|15903472|). Residues 9-168 are 52% similar to the protein from Lactococcus lactis (gi|628943|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1314 (5e-63).","

InterPro
IPR001796
Domain

Dihydrofolate reductase region
PR00070	$\"[20-30]T$ $\"[34-42]T$ $\"[47-58]T$ $\"[100-114]T$	DHFR
PF00186	$\"[8-168]T$	DHFR_1
PS00075	$\"[20-42]T$	DHFR

InterPro
IPR012259
Family

Dihydrofolate reductase
PIRSF000194	$\"[8-168]T$	DHFR
PTHR11549:SF1	$\"[20-156]T$	DHFR

noIPR
unintegrated

unintegrated
G3DSA:3.40.430.10	$\"[9-170]T$	G3DSA:3.40.430.10
PTHR11549	$\"[20-156]T$	PTHR11549
SSF53597	$\"[4-170]T$	SSF53597

","BeTs to 6 clades of COG0262COG name: Dihydrofolate reductaseFunctional Class: HThe phylogenetic pattern of COG0262 is ----y-v-eBrh--GP--in-Number of proteins in this genome belonging to this COG is 1","***** IPB001796 (Dihydrofolate reductase) with a combined E-value of 4.7e-31. IPB001796A 12-23 IPB001796B 28-42 IPB001796C 45-57 IPB001796D 60-72 IPB001796E 101-110 IPB001796F 120-136","Residues 14-159 are 53% similar to a (DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE NADP ONE-CARBON) protein domain (PD000692) which is seen in O85263_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 12 13:36:54 2002","Mon Jan 7 08:56:47 2002","Sat Oct 12 13:36:54 2002","Mon Jan 7 08:56:47 2002","Mon Jan 7 08:56:47 2002","Mon Jan 7 08:56:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0859 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 08:57:17 2002","Mon Jan 7 08:56:47 2002","pdb|1AO8| Dihydrofolate Reductase Complexed With Methotrexate... 117 7e-028pdb|3DFR| Dihydrofolate Reductase (E.C.1.5.1.3) Complex With... 116 2e-027pdb|1DHJ|B Chain B, Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3... 91 9e-020","SMU.947","","Residues 8 to 168 (E-value = 2.9e-43) place SMu0859 in the DiHfolate_red family which is described as Dihydrofolate reductase (PF00186)","Mon Jan 7 08:56:47 2002","24379390","","","Pikis,A., Donkersloot,J.A., Rodriguez,W.J. and Keith,J.M.A conservative amino acid mutation in the chromosome-encodeddihydrofolate reductase confers trimethoprim resistance inStreptococcus pneumoniaeJ. Infect. Dis. 178 (3), 700-706 (1998)PubMed: 9728538Maskell,J.P., Sefton,A.M. and Hall,L.M.C.Multiple mutations modulate the function of dihydrofolate reductase in trimethoprim-resistant Streptococcus pneumoniaeAntimicrob. Agents Chemother. 45 (4), 1104-1108 (2001)Pubmed:11257022Adrian,P.V. and Klugman,K.P.Mutations in the dihydrofolate reductase gene oftrimethoprim-resistant isolates of Streptococcus pneumoniaeAntimicrob. Agents Chemother. 41 (11), 2406-2413 (1997)PubMed: 9371341Leszczynska,K., Bolhuis,A., Leenhouts,K., Venema,G. andCeglowski,P.Cloning and molecular analysis of the dihydrofolate reductase genefrom Lactococcus lactisAppl. Environ. Microbiol. 61 (2), 561-566 (1995)PubMed: 7574597","","Mon Jan 7 09:25:34 2002","1","","","SMU.947","820" "SMu0860","897864","898034","171","ATGCAAAGAAGTATTTTTGGTGTATTTACTGCTTTTTTATTTGTGATTTGTATTTTATGTGCTGTTCCTGCATTTAAGAAAAATCGTTATGGTTTAGGGGTGTTTTTCTTGTTAAATGCTCTGACTAATATTGTAAATACCATTCATGCTTTTTATGGAACCCTGTTTTAA","10.40","4.12","6305","MQRSIFGVFTAFLFVICILCAVPAFKKNRYGLGVFFLLNALTNIVNTIHAFYGTLF","898033","","conserved hypothetical protein","Cytoplasm, Extracellular","Limited matches in gapped BLAST to hypothetical protein: residues 1-56 are 83% similar to the protein in S.pyogenes (gi|15674909|) and are 62% similar to the protein from S.pneumoniae (gi|15901413|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1313 (1e-23).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[35-55]?$	transmembrane_regions

","BeTs to 3 clades of COG0554COG name: Glycerol kinaseFunctional Class: CThe phylogenetic pattern of COG0554 is a---yqVcebrh--gpo----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 00:11:12 2002","Mon Jan 7 09:28:20 2002","Mon Oct 28 00:11:12 2002","Mon Jan 7 09:28:20 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0860 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 28 00:11:12 2002","","No significant hits to the NCBI PDB database.","SMU.948","","No significant hits to the Pfam 11.0 database","Mon Jan 7 09:28:20 2002","24379391","","","","","","1","","","SMU.948","938" "SMu0861","898059","899291","1233","ATGGCTGGAAATAGAACCAATGATGTCACAGTGCATTGTTCATTCTGTGGCAAAAATCAAGATGAAGTTAAAAAAATTATTGCAGGTAATGGCGTTTTTATTTGCAATGAATGTGTTGAATTATCACAAGAAATTATCCGTGAAGAACTAGCAGAAGAGGTATTGGCTGATCTTTCAGAAGTTCCAAAACCAAAAGAATTGTTGGCAATACTAGACAGTTATGTTATCGGTCAGGACCGTGCCAAACGTGCTTTAGCAGTTGCTGTCTATAATCATTATAAGCGTATCAGTTTTACTGAGAGCCAAGACGACCAAGATGTTGACTTACAAAAATCAAATATTCTTATGATTGGACCGACAGGTTCTGGAAAAACTTTCTTAGCACAGACTTTGGCTAAGAGTCTCAATGTGCCCTTTGCTATTGCTGATGCAACAGCCTTGACTGAAGCGGGTTATGTAGGTGAAGATGTTGAAAACATTTTGCTTAAATTGATTCAGGCAGCTGATTATAATGTTGAACGCGCGGAGCGTGGCATCATTTATGTTGATGAAATTGATAAGATTGCTAAAAAAGGCGAAAATGTTTCCATCACACGTGATGTATCTGGTGAAGGTGTCCAACAAGCTCTGCTTAAGATTATTGAAGGAACAGTAGCTAGTGTGCCACCACAAGGTGGTCGGAAACATCCCCAACAGGAAATGATTCAAATTGATACGAAAAACATCCTCTTCATAGTTGGTGGCGCTTTTGATGGTATTGAAGATATCGTTAAACAGCGTTTGGGTGAGAAAATTATTGGCTTTGGTCAAAATAATAAGAAGATTGATGATCAATCTTCTTATATGCAAGAAATTATTTCAGAAGACATTCAAAAATTTGGTCTTATTCCAGAGTTTATTGGTCGTTTGCCAGTTTTAGCTGCGCTTGAGCAATTAACGGTTGATGATTTGGTTAAGATTTTGACAGAACCTAAAAATGCTTTAGTTAAACAATATCAGACGCTTTTATCTTATGATGGTGTTGAGCTTGAGTTTGATCAAGAGGCGCTTCAAGCGATTGCTCAAAAGGCGATTGAACGTAAGACAGGCGCACGCGGTCTTCGCTCTATTATTGAAGAAACGATGCTGGATCTGATGTTTGAAATTCCGAGTCAAGAGGATGTCACTTGCGTTCGCATTACTAAGAAAGCGGTAGAAGGGACCGACAAACCTATTCTTGAGACAGCTTCCTAA","4.50","-20.46","45170","MAGNRTNDVTVHCSFCGKNQDEVKKIIAGNGVFICNECVELSQEIIREELAEEVLADLSEVPKPKELLAILDSYVIGQDRAKRALAVAVYNHYKRISFTESQDDQDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQIDTKNILFIVGGAFDGIEDIVKQRLGEKIIGFGQNNKKIDDQSSYMQEIISEDIQKFGLIPEFIGRLPVLAALEQLTVDDLVKILTEPKNALVKQYQTLLSYDGVELEFDQEALQAIAQKAIERKTGARGLRSIIEETMLDLMFEIPSQEDVTCVRITKKAVEGTDKPILETAS","899290","For other 'clp' genes see SMu0511 (clpE); SMu0868 (clpL), (clpE); SMu1844 (clpC); SMu1524 (clpP) and SMu1300 (clpB).For ATP-dependent Clp protease,ATP-binding subunit see SMu0868. For ATP-dependent Clp protease,ATP-binding subunit ClpB see SMu1300. For ATP-dependent Clp protease, proteolytic subunit see SMu1524. For ATP-dependent Clp protease, ATP-binding subunit see SMu1844. From Genbank:[gi:13878442]ATP-dependent specificity component of the CLP protease directs the protease to specific substrates.It can perform chaperone functions in the absence of CLPP.","ATP-dependent Clp protease subunit X","Cytoplasm","Several matches in gapped BLAST to ATP-dependent Clp protease subunit X: residues 1-409 are 88% similar to the enzyme in S.pyogenes (gi15674910) and are 86% similar to the protein from S.pneumoniae (gi15901412).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1312 (0.0).","

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[110-260]T$	AAA

InterPro
IPR004487
Family

ClpX, ATPase regulatory subunit
PTHR11262:SF4	$\"[7-410]T$	ClpX
TIGR00382	$\"[1-407]T$	clpX

InterPro
IPR010603
Domain

Zinc finger, C4-type
PF06689	$\"[10-49]T$	zf-C4_ClpX

InterPro
IPR011593
Domain

Isopentenyl transferase-like
PD005388	$\"[114-144]T$	IPPtrans_like

InterPro
IPR013093
Domain

ATPase AAA-2
PF07724	$\"[109-306]T$	AAA_2

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.60	$\"[311-410]T$	G3DSA:1.10.8.60
G3DSA:3.40.50.300	$\"[53-310]T$	G3DSA:3.40.50.300
PTHR11262	$\"[7-410]T$	PTHR11262
SSF52540	$\"[57-407]T$	SSF52540
SSF57716	$\"[10-47]T$	SSF57716

","BeTs to 12 clades of COG1219COG name: ATP-dependent protease Clp, ATPase subunit ClpXFunctional Class: OThe phylogenetic pattern of COG1219 is ----yqvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000623 (Shikimate kinase) with a combined E-value of 3.5e-07. IPB000623A 114-143***** IPB001270 (Chaperonins clpA/B) with a combined E-value of 4.9e-06. IPB001270E 90-144 IPB001270G 295-309 IPB001270H 357-371","Residues 115-216 are 36% similar to a (REPLICATION ATP-BINDING DNA-BINDING INITIATOR) protein domain (PD002717) which is seen in YB56_METJA.Residues 188-320 are 30% similar to a (CHAPERONE MCX1 ATP-BINDING CLPX-LIKE) protein domain (PD259050) which is seen in MCX1_YEAST.Residues 325-406 are 60% similar to a (ATP-BINDING PROTEASE SUBUNIT) protein domain (PD257346) which is seen in Q9PIM0_CAMJE.Residues 176-250 are 96% similar to a (ATP-BINDING PROTEASE SUBUNIT) protein domain (PD338319) which is seen in CLPX_LACLA.Residues 61-139 are 74% similar to a (ATP-BINDING PROTEASE SUBUNIT CHAPERONE) protein domain (PD189825) which is seen in CLPX_LACLA.Residues 13-49 are 62% similar to a (ATP-BINDING PROTEASE SUBUNIT) protein domain (PD348828) which is seen in CLPX_RICPR.Residues 39-379 are 80% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9L6G2_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 10 09:39:19 2006","Mon Jan 7 09:31:25 2002","Thu Aug 10 09:39:19 2006","Mon Jan 7 09:31:25 2002","Mon Jan 7 09:31:25 2002","Mon Jan 7 09:31:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0861 is paralogously related (blast p-value < 1e-3) to SMu0868,a predicted ATP-dependent Clp protease, SMu1844,a predicted ATP-dependent Clp protease, ATP-binding subunit (Class III stress response-related ATPase) SMu0013,a predicted cell division protein FtsH and SMu0511,a predicted ATP-dependent protease Clp.","Mon Jan 14 11:26:37 2002","Thu Aug 10 09:39:19 2006","pdb1E94E Chain E, Hslv-Hslu From E.Coli >gi11513636pdb1E94... 97 3e-021pdb1DO2A Chain A, Trigonal Crystal Form Of Heat Shock Locus U... 97 3e-021pdb1G3IA Chain A, Crystal Structure Of The Hsluv Protease-Cha... 96 1e-020","SMU.949","","Residues 13 to 49 (E-value = 2.4e-23) place SMu0861 in the zf-C4_ClpX family which is described as ClpX C4-type zinc finger (PF06689)Residues 113 to 330 (E-value = 2.1e-23) place SMu0861 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)","Thu Aug 10 09:39:19 2006","24379392","","","Skinner,M.M. and Trempy,J.E.Expression of clpX, an ATPase subunit of the Clp protease, is heatand cold shock inducible in Lactococcus lactisJ. Dairy Sci. 84 (8), 1783-1785 (2001)PubMed: 11518300Gerth,U., Wipat,A., Harwood,C.R., Carter,N., Emmerson,P.T. andHecker,M.Sequence and transcriptional analysis of clpX, a class-IIIheat-shock gene of Bacillus subtilisGene 181 (1-2), 77-83 (1996)PubMed: 8973311Osteras,M., Stotz,A., Schmid Nuoffer,S. and Jenal,U.Identification and transcriptional control of the genes encodingthe Caulobacter crescentus ClpXP proteaseJ. Bacteriol. 181 (10), 3039-3050 (1999)PubMed: 10322004Gottesman,S., Clark,W.P., de Crecy-Lagard,V. and Maurizi,M.R.ClpX, an alternative subunit for the ATP-dependent Clp protease ofEscherichia coli. Sequence and in vivo activitiesJ. Biol. Chem. 268 (30), 22618-22626 (1993)PubMed: 8226770Wojtkowiak,D., Georgopoulos,C. and Zylicz,M.Isolation and characterization of ClpX, a new ATP-dependentspecificity component of the Clp protease of Escherichia coliJ. Biol. Chem. 268 (30), 22609-22617 (1993)PubMed: 8226769Wawrzynow,A., Wojtkowiak,D., Marszalek,J., Banecki,B., Jonsen,M.,Graves,B., Georgopoulos,C. and Zylicz,M.The ClpX heat-shock protein of Escherichia coli, the ATP-dependentsubstrate specificity component of the ClpP-ClpX protease, is anovel molecular chaperoneEMBO J. 14 (9), 1867-1877 (1995)PubMed: 7743994","Mon Mar 25 08:11:47 2002","Mon Jan 7 09:47:21 2002","1","","","SMU.949","140" "SMu0862","899307","899900","594","ATGAGTGAATTTTTAAATACCCACAATGCTTCTATTCTTCTTAGTGCGGTCAATAAATCGCATTACCCTCAAGATGACTTACCTGAAATTGCCCTAGCTGGCCGCTCTAATGTTGGTAAATCCAGTTTTATCAATACGCTGTTAGGCCGAAAAAATCTGGCTCGTACGTCTAGTAAGCCCGGAAAGACGCAATCGTTGAATTTTTATAATATCGACGATAAGCTTCGCTTTGTGGATGTGCCCGGTTATGGGTATGCCAAGGTTTCAAAGAAAGAACGCGCCAAGTGGGGCAAAATGATTGAAGAGTATTTAACTAGTCGTGAAAATTTACGAGCAGTCGTGAGTCTGGTTGATTTTCGTCATGATCCCAGTTCAGATGATGTACAGATGTATGATTTTTTGAAATACTATGAAATTCCTGTTATTTTAGTTGCGACAAAGGCTGATAAGGTTCCTCGTGGCAAATGGAATAAACAGGAATCTGCTATAAAAAAGAAACTTGATTTTGATTCCAATGATGCTTTTATCATCTTTTCGTCAGTTGATCGGACAGGTTTGGATACATCTTGGGATGCCATTTTAGAGTCTCTTTAA","9.70","3.72","22318","MSEFLNTHNASILLSAVNKSHYPQDDLPEIALAGRSNVGKSSFINTLLGRKNLARTSSKPGKTQSLNFYNIDDKLRFVDVPGYGYAKVSKKERAKWGKMIEEYLTSRENLRAVVSLVDFRHDPSSDDVQMYDFLKYYEIPVILVATKADKVPRGKWNKQESAIKKKLDFDSNDAFIIFSSVDRTGLDTSWDAILESL","899899","For other 'lep' genes see SMu1271 (lepA) and SMu1704 (lepC).From Genbank: [gi:13124218]This protein is necessary for normal cell division and for the maintenance of normal septation.","GTP-binding protein","Periplasm, Membrane","Several matches in gapped BLAST to possible GTP-binding protein: residues 3-197 are 84% similar to the protein in S.pyogenes (gi|15674911|). Residues 5-197 are 83% similar to the protein from S.pneumoniae (gi|15901411|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1311 (1e-100).","

InterPro
IPR001806
Family

Ras GTPase
PR00449	$\"[28-49]T$ $\"[137-150]T$ $\"[175-197]T$	RASTRNSFRMNG

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[28-149]T$	MMR_HSR1

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[25-195]T$	small_GTP

InterPro
IPR005289
Domain

GTP-binding
TIGR00650	$\"[33-82]T$	MG442

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-197]T$	G3DSA:3.40.50.300
PTHR11649	$\"[22-195]T$	PTHR11649
PTHR11649:SF13	$\"[22-195]T$	PTHR11649:SF13
SSF52540	$\"[5-197]T$	SSF52540

","BeTs to 11 clades of COG0218COG name: Predicted GTPasesFunctional Class: RThe phylogenetic pattern of COG0218 is am-kyqv-eb-hujgp----xNumber of proteins in this genome belonging to this COG is 1","***** IPB000765 (GTP1/OBG family) with a combined E-value of 8.7e-07. IPB000765 28-71","Residues 27-85 are 44% similar to a (DOMAIN OF UNKNO N) protein domain (PD310163) which is seen in Q9N9N5_LEIMA.Residues 83-194 are 77% similar to a (GTP-BINDING DIVISION CELL SEPTATION) protein domain (PD006719) which is seen in Q9CGE5_LACLA.Residues 28-82 are 87% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9CGE5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 10:00:07 2002","Mon Jan 28 10:05:51 2002","Mon Oct 14 10:00:07 2002","Mon Jan 7 09:49:23 2002","Mon Jan 7 09:49:23 2002","Mon Jan 7 09:49:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0862 is paralogously related (blast p-value < 1e-3) to SMu1471, and SMu0903,both predicted GTP-binding proteins; and SMu0519, a predicted ferrous ion transport protein B.","Mon Jan 28 10:07:54 2002","","No significant hits to the NCBI PDB database.","SMU.950","Mon Jan 7 09:51:39 2002","No significant hits to the Pfam 11.0 database","Mon Jan 7 09:49:23 2002","24379393","","","Dassain,M., Leroy,A., Colosetti,L., Carole,S. and Bouche,J.P.A new essential gene of the 'minimal genome' affecting celldivisionBiochimie 81 (8-9), 889-895 (1999)PubMed: 10572302Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL.Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels.Genes Dev. 2001 May 1;15(9):1093-103.PMID: 11331605 Kobayashi G, Moriya S, Wada C.Deficiency of essential GTP-binding protein ObgE in Escherichia coli inhibits chromosome partition.Mol Microbiol. 2001 Sep;41(5):1037-51.PMID: 11555285","","Mon Oct 14 10:00:07 2002","1","","","SMU.950","577" "SMu0863","900229","901605","1377","ATGGAAAACCACAATTTTGAAAATGAAGGTCAGTTTAAGCGAAAAATGACCAGTCGTCATCTCTTTATGTTGTCCTTAGGCGGTGTTATTGGAACAGGGCTTTTCTTAAGTTCAGGTTATACAATTGCTCAAGCTGGTCCCTTAGGAGCGGTAATTTCTTATTTAGTTGGTGCTATTGTTGTTTACCTTGTGATGCTTTCTTTGGGTGAATTAGCAGTAGCTATGCCTGTTACAGGTTCTTTTCATACCTATGCTACCAAATTCATCAGTCCTGGAACTGGTTTTACCATTGCTTGGCTTTATTGGATTTGTTGGACGGTTGCTTTAGGGACAGAGTTTCTTGGTGCAGGTATGTTGATGGGACGGTGGGTTCCTTATGTTCCCACTTGGGTCTTTGCAGCACTTTTTGCCTTGCTTATTTTTGGTCTCAATGCTCTCAGTGTTCGTTCTTTTGCTGAAGCAGAATCCTTCTTTTCTAGTATAAAGGTTTTAGCTATTCTTGTTTTTATTATTCTTGGTTTTGGAGCCATGCTTGGTTTGGTTTCTTTTAATGGTAAGCACGAAGTATTTCTTTTTAGTCATTTGACAGCTCATGGAGCTCTGCCAAAGGGACTTCCAGCATTAATGTCAGTCATGCTGGCAGTTAATTATGCCTTTTCTGGAACAGAGCTCATCGGGATTGCAGCGGGAGAAACGAACAATCCTAAAGAAGCTGTTCCCAAGGCTATTAAAACAACAATTGGTCGTTTAGTGATTTTCTTTGTATTGACAATTGTTGTCTTAGCATCGTTTTTACCAATGAAAGAAGCAGGTGTATCCAGTGCTCCTTTTGTTGATGTTTTTGATAAGATGGGCATTCCTTTTGCTGCTGATATCATGAATTTCGTTATTTTGACAGCTATTTTGTCTGCTGGTAATTCAGGACTTTATGCTTCCAGCCGCATGCTTTGGTCTTTGGCCAACGAAGGTATGATTAGTCCGAGGGTTGTTAAAATCAATGAACACGGTGTTCCTATGAGAGCTTTGCTCCTATCGATGGCAGGTGCTGTTTTATCCTTGTTTTCAAGTATCTATGCGGCAGATACCGTTTATTTGGCTCTGATGTCAATCGCTGGCTTTGCTGTTGTTGTAGTCTGGTTGTCCATTCCTATGGCACAAATTAATTTTCGTAAGGAATGGCTGAAAAGTCATGCCCAAGAAGACTTGTTTTATAAAACGCCTTTTACTCCAATTCTGCCTTACATTACGATTATGCTATTGTTGATTTCGATTATTGGTATTGCTTGGGATGCATCACAAAGAGCGGGTCTTTATTTCGGTATACCTTTTATTCTACTTTGTTATCTTTATTATTATTGGCGGCATAAGACATTGTAA","9.70","7.07","49932","MENHNFENEGQFKRKMTSRHLFMLSLGGVIGTGLFLSSGYTIAQAGPLGAVISYLVGAIVVYLVMLSLGELAVAMPVTGSFHTYATKFISPGTGFTIAWLYWICWTVALGTEFLGAGMLMGRWVPYVPTWVFAALFALLIFGLNALSVRSFAEAESFFSSIKVLAILVFIILGFGAMLGLVSFNGKHEVFLFSHLTAHGALPKGLPALMSVMLAVNYAFSGTELIGIAAGETNNPKEAVPKAIKTTIGRLVIFFVLTIVVLASFLPMKEAGVSSAPFVDVFDKMGIPFAADIMNFVILTAILSAGNSGLYASSRMLWSLANEGMISPRVVKINEHGVPMRALLLSMAGAVLSLFSSIYAADTVYLALMSIAGFAVVVVWLSIPMAQINFRKEWLKSHAQEDLFYKTPFTPILPYITIMLLLISIIGIAWDASQRAGLYFGIPFILLCYLYYYWRHKTL","901604","The amino acid permease ROCE is a possible transport protein involved in arginine degradative pathway.It transports arginine or ornithine [gi:730601].","amino acid permease","Membrane, Cytoplasm","Several matches in gapped BLAST to amino acid permease: residues 4-456 are 54% similar to the enzyme in B.subtilis (gi|16077309|). Residues 7-452 are 49% similar to the protein from E.coli (gi|16128245|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1306 (0.0).","

InterPro
IPR002293
Family

Amino acid/polyamine transporter I
PTHR11785	$\"[7-456]T$	AA/rel_permease1

InterPro
IPR004840
Family

Amino acid permease
PS00218	$\"[45-76]T$	AMINO_ACID_PERMEASE_1

InterPro
IPR004841
Domain

Amino acid permease-associated region
PF00324	$\"[20-457]T$	AA_permease

noIPR
unintegrated

unintegrated
PIRSF006060	$\"[10-458]T$	AA_transporter
PTHR11785:SF22	$\"[7-456]T$	PTHR11785:SF22

","BeTs to 4 clades of COG0833COG name: Amino acid transportersFunctional Class: EThe phylogenetic pattern of COG0833 is ----Y---EB--uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002027 (Amino acid permease) with a combined E-value of 4e-56. IPB002027A 19-47 IPB002027B 144-163 IPB002027C 217-255 IPB002027D 299-338","Residues 87-197 are 43% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME AMINO AMINO-ACID) protein domain (PD031626) which is seen in O31462_BACSU.Residues 11-76 are 50% similar to a (AMINO-ACID TRANSPORT BASIC PERMEASE) protein domain (PD078127) which is seen in ALP1_YEAST.Residues 78-131 are 57% similar to a (TRANSPORT AMINO-ACID PERMEASE) protein domain (PD362960) which is seen in ROCE_BACSU.Residues 386-456 are 40% similar to a (TRANSPORT PERMEASE AMINO-ACID COMPLETE) protein domain (PD095982) which is seen in O31462_BACSU.Residues 7-76 are 77% similar to a (TRANSPORT PERMEASE AMINO-ACID TRANSMEMBRANE PROTEOME) protein domain (PD284669) which is seen in O31462_BACSU.Residues 277-372 are 63% similar to a (TRANSPORT PERMEASE AMINO-ACID TRANSMEMBRANE COMPLETE) protein domain (PD000262) which is seen in O31462_BACSU.Residues 219-276 are 50% similar to a (TRANSPORT AMINO ACID AMINO-ACID PERMEASE TRANSMEMBRANE) protein domain (PD000442) which is seen in MMUP_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 11:53:23 2002","Mon Jan 28 11:53:23 2002","Mon Oct 14 10:01:27 2002","Mon Jan 7 10:30:19 2002","Mon Jan 7 10:30:19 2002","Mon Jan 7 10:30:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0863 is paralogously related (blast p-value < 1e-3) to SMu1320, SMu0014, and SMu0239, predicted amino acid permeases.","Mon Jan 28 11:53:23 2002","","No significant hits to the NCBI PDB database.","SMU.951","","Residues 20 to 458 (E-value = 4.6e-127) place SMu0863 in the AA_permease family which is described as Amino acid permease (PF00324)","Mon Jan 7 10:30:19 2002","24379394","","","Gardan,R., Rapoport,G. and Debarbouille,M.Expression of the rocDEF operon involved in arginine catabolism inBacillus subtilisJ. Mol. Biol. 249 (5), 843-856 (1995)PubMed: 7540694Calogero,S., Gardan,R., Glaser,P., Schweizer,J., Rapoport,G. andDebarbouille,M.RocR, a novel regulatory protein controlling arginine utilizationin Bacillus subtilis, belongs to the NtrC/NifA family oftranscriptional activatorsJ. Bacteriol. 176 (5), 1234-1241 (1994)PubMed: 8113162","","Mon Jan 7 10:38:23 2002","1","","","SMU.951","139" "SMu0864","901615","902565","951","ATGGGACGTTTCAAAACATTATTAAATCAAGAAGATTATCTTATTTTACATGGTGCTTTGGGAACAGAATTGGAATTTTTGGGTTATGATGTTTCAGGCAAACTATGGTCGGCCAAATACCTTTTGGAAAATCCAAGTATCATTCAAACGATTCATGAAACTTATTTACGTTCAGGTTCTGATATTGTAACTACATCTAGTTACCAAGCTAGTTACCAAGGTTTATGTGACTATGGTTTAAGTCAGGAAGAAGCTGAAAAAATGATAGCCTTGACAGTTAGTTTAGCTAAAAATGCTAGAGAGAAAGTCTGGCAGGAGCTGAGTGAAAAAGAAAAACAAGTTCGCCCCTATCCTTTAATCAGTGGTGATGTTGGCCCTTATGCGGCTTATTTAGCTGATGGTTCTGAATATACAGGGAATTATGGTCAGCTTGATAAGGAAGTTCTTAAAGATTTTCATAGGTCACGTATTAAAATCTTAGTTGATGAGGGTAGTGATTTATTAGCGCTTGAGACTATTCCAAATTTCTTAGAAGCACAGGCCTTGGTTGAACTCTTACAGGAAGAATTTCCGTCTGTAGAAGCTTACATGAGTTTTACAGCTCAAAATGGCACTACGATTTCTGACGGAACAGCCATAGAAGAAGTGGCTGAACTGATTGATAAGGCGTCGCAAATTCTGGCTTTAGGTATTAATTGCAGCTCACCGTCAGTGTACAGCAGTCTTTTGAAAAAGATTGCCGATATAACAGATAAACCTTTAGTGACTTACCCTAATTCTGGTGAAGTCTATGATGGCCAACACCAAATGTGGACACAATCTGCTGATATATCGCATACGCTTTTGGAAAATACTAAAATTTGGCATACATTCGGTGCCAAAGTAGTGGGCGGCTGCTGTCGTACGAGACCAAATGATATTGAAAGTTTAAGCAGAGGCCTGAGAGAATGA","4.60","-16.72","35070","MGRFKTLLNQEDYLILHGALGTELEFLGYDVSGKLWSAKYLLENPSIIQTIHETYLRSGSDIVTTSSYQASYQGLCDYGLSQEEAEKMIALTVSLAKNAREKVWQELSEKEKQVRPYPLISGDVGPYAAYLADGSEYTGNYGQLDKEVLKDFHRSRIKILVDEGSDLLALETIPNFLEAQALVELLQEEFPSVEAYMSFTAQNGTTISDGTAIEEVAELIDKASQILALGINCSSPSVYSSLLKKIADITDKPLVTYPNSGEVYDGQHQMWTQSADISHTLLENTKIWHTFGAKVVGGCCRTRPNDIESLSRGLRE","902564","This enzyme catalyzes methyl transfer from S-methylmethionine or S-adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [gi:2495491].","homocysteine S-methyltransferase","Cytoplasm","Several matches in gapped BLAST to homocysteine S-methyltransferase: residues 5-315 are 42% similar to the enzyme in Clostridium acetobutylicum (gi15896591). Residues 15-315 are 41% similar to the protein from Arabidopsis thaliana (gi15230929).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1305 (1e-113).","

InterPro
IPR003726
Domain

Homocysteine S-methyltransferase
G3DSA:3.20.20.330	$\"[8-316]T$	S_methyl_trans
PF02574	$\"[13-316]T$	S-methyl_trans
PS50970	$\"[2-314]T$	HCY
SSF82282	$\"[2-315]T$	S_methyl_trans

noIPR
unintegrated

unintegrated
PTHR21091	$\"[35-312]T$	PTHR21091
PTHR21091:SF4	$\"[35-312]T$	PTHR21091:SF4

","BeTs to 4 clades of COG2040COG name: Predicted methyltransferasesFunctional Class: RThe phylogenetic pattern of COG2040 is ----Y--cebr----------Number of proteins in this genome belonging to this COG is 1","***** IPB003726 (Homocysteine S-methyltransferase) with a combined E-value of 9.7e-19. IPB003726A 45-68 IPB003726B 228-249 IPB003726C 292-304","Residues 14-211 are 43% similar to a (METHYLTRANSFERASE METHIONINE PROTEOME COMPLETE SYNTHASE) protein domain (PD003711) which is seen in O31463_BACSU.Residues 226-315 are 45% similar to a (TRANSFERASE METHYLTRANSFERASE) protein domain (PD009874) which is seen in Q9SDL7_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 24 17:01:38 2002","Thu Jan 24 17:01:38 2002","Wed Aug 30 16:32:46 2006","Mon Jan 7 10:43:55 2002","Mon Jan 7 10:43:55 2002","Mon Jan 7 10:43:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0864 is paralogously related (blast p-value < 1e-3) to SMu0797, a predicted conserved hypothetical protein.","Mon Jan 28 14:04:53 2002","","No significant hits to the NCBI PDB database.","SMU.952","","Residues 13 to 316 (E-value = 4.3e-84) place SMu0864 in the S-methyl_trans family which is described as Homocysteine S-methyltransferase (PF02574)","Mon Jan 7 10:43:55 2002","24379395","","","Ranocha,P., Bourgis,F., Ziemak,M.J., Rhodes,D., Gage,D.A. andHanson,A.D.Characterization and functional expression of cDNAs encodingmethionine-sensitive and -insensitive homocysteineS-methyltransferases from ArabidopsisJ. Biol. Chem. 275 (21), 15962-15968 (2000)PubMed: 10747987Ranocha,P., McNeil,S.D., Ziemak,M.J., Li,C., Tarczynski,M.C. andHanson,A.D. The S-methylmethionine cycle in angiosperms: ubiquity, antiquityand activityPlant J. 25 (5), 575-584 (2001)PubMed: 11309147Thanbichler,M., Neuhierl,B. and Bock,A.S-methylmethionine metabolism in Escherichia coliJ. Bacteriol. 181 (2), 662-665 (1999)PubMed: 9882684Neuhierl,B., Thanbichler,M., Lottspeich,F. and Bock,A.A family of S-methylmethionine-dependent thiol/selenolmethyltransferases. Role in selenium tolerance and evolutionaryrelationJ. Biol. Chem. 274 (9), 5407-5414 (1999)PubMed: 10026151","","Mon Jan 7 10:53:21 2002","1","","","SMU.952","576" "SMu0865","903961","902699","1263","ATGGTTAGTAAATATCATGAAATTTTTTTAAATATTATACAGCAAATCGAAGATGGTCAACTAAAACGCGGCGATAAACTGCCTTCTATTCGTCAACTGAGCCAAGATTTTCACTGCAGCAAAGATACTGTTCAAAAAGCTTTGTCAGAATTGAAATATCAAAAATATATTTATCCTATTCTCAAAAGCGGTTATTACGTTTTTGAGGATAATCATGAAGAAGAAATCCTACCTCCAATCTCTCCTTCTAATTACCACAATATTGCTTACGAAGATTTTAGAACCTGCATGAATGAGACTTTAGTTGGGCGGGAAGATTATCTCTTCAACTACTATCATCAAGAAGAAGGATTGGAAGAGCTGACGCAATCTTTACAGGCGCTTTTCGTAGACGAAGCCATTTACAGCAAAAAAGAAAATATCGTTGTCACTTCTGGCAGCCAACAAGCCCTTTACATCCTATCACAGATGACCTTTCCCAATCAAAAAGAGATTATTTTACTGGAACAGCCGACCTACCATCGCATGAACACCTTGGTTAAATCGCAAAATCTTCCCTACTTAACTATTGAGCGAGGATTTGATGGACTTGATTTTAATCGACTAGAGGAGATTTTTAAACAAGAAAAGATTAAGTTCTTTTATACTATTCCGCGTCTATCTAACCCTTTGGGTTTGTCATACAGTCACAAAGAAAAACAAACTTTGGTAGAATTAGCTCATAAATACGATGTCTACATTATTGAAGATGACTATATGGCAGATTTTGACAGAGCCAGCAATGTTTCCTTACATTACTTAGATACCAACGATAGGATTATTTATTTAAAATCATTTTCTATGTCGCTTTTTCCTGCTTTACGTTTAGGAAGTTTAATCCTTCCTAAGAAACTCTTGAAAAAATTTCTTGATTATAAAAATCTGATTGATTACGATACTAATCTTATCATGCAAAAGGCACTCTCTTTGTATATTGATAATGGTATGTTCGCTAAAAATAAGAAACGTCTCAAGCAAATGTATTATCAAAAAACATCTGAGTTAGCAAAAGAATTTTCAACTTTTACTCTCAAGCTTCCTCATCATATTTTCCAAGATTCATTAATATTACAATTACCAACTAAAGTCAACCTTGCTCTTTTAAAGTATAGACTCAATTCGCCTAATTTTTTGGAAAAAAATTATATTAGTACTTGCCCCTACCACTTTATTCAACTGCAAGCAGGAGAAAACTGGCAGAATTTGCTAACTATTTTCGAGTAA","6.80","-1.22","49654","MVSKYHEIFLNIIQQIEDGQLKRGDKLPSIRQLSQDFHCSKDTVQKALSELKYQKYIYPILKSGYYVFEDNHEEEILPPISPSNYHNIAYEDFRTCMNETLVGREDYLFNYYHQEEGLEELTQSLQALFVDEAIYSKKENIVVTSGSQQALYILSQMTFPNQKEIILLEQPTYHRMNTLVKSQNLPYLTIERGFDGLDFNRLEEIFKQEKIKFFYTIPRLSNPLGLSYSHKEKQTLVELAHKYDVYIIEDDYMADFDRASNVSLHYLDTNDRIIYLKSFSMSLFPALRLGSLILPKKLLKKFLDYKNLIDYDTNLIMQKALSLYIDNGMFAKNKKRLKQMYYQKTSELAKEFSTFTLKLPHHIFQDSLILQLPTKVNLALLKYRLNSPNFLEKNYISTCPYHFIQLQAGENWQNLLTIFE","902704","","transcriptional regulator, GntR family","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein and to transcriptional regulator of MocR family: residues 3-416 are 48% similar to conserved hypothetical protein in S.pneumoniae (gi15901247). Residues 2-354 are 29% similar to the protein from Clostridium acetobutylicum (gi15895564).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0099 (1e-105).","

InterPro
IPR000524
Domain

Bacterial regulatory protein GntR, HTH
PF00392	$\"[4-67]T$	GntR
SM00345	$\"[8-67]T$	HTH_GNTR
PS50949	$\"[2-70]T$	HTH_GNTR

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[5-70]T$	Wing_hlx_DNA_bd

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[112-327]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[40-370]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[96-381]T$	PTHR11751
PTHR11751:SF11	$\"[96-381]T$	PTHR11751:SF11

","BeTs to 5 clades of COG1167COG name: Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologsFunctional Class: K,EThe phylogenetic pattern of COG1167 is ---kY-v-EB-----------Number of proteins in this genome belonging to this COG is 2","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 1e-11. IPB000524 27-67","Residues 117-285 are 44% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in YCXD_BACSU.Residues 8-67 are 43% similar to a (TRANSCRIPTIONAL REGULATOR DNA-BINDING) protein domain (PD000726) which is seen in Q9I4J3_PSEAE.Residues 2-67 are 42% similar to a (REGULATOR AMINOTRANSFERASE PROTEOME) protein domain (PD389999) which is seen in YCXD_BACSU.Residues 142-251 are 26% similar to a (AMINOTRANSFERASE UBP3-PET122 II 2.6.1.-) protein domain (PD202809) which is seen in Q9VTD9_DROME.Residues 2-67 are 59% similar to a (PROTEOME YYDK REGULATION TRANSCRIPTION) protein domain (PD412955) which is seen in Q9X4U3_STRSU.Residues 256-333 are 53% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD259563) which is seen in Q9X4U3_STRSU.Residues 88-131 are 65% similar to a (DOMAIN OF UNKNO N) protein domain (PD262787) which is seen in Q9X4U3_STRSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 10:16:28 2002","Tue Sep 5 10:47:19 2006","Tue Sep 5 10:47:19 2006","Mon Jan 7 11:02:43 2002","Mon Jan 7 11:02:43 2002","Mon Jan 7 11:02:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0865 is paralogously related (blast p-value < 1e-3) to SMu0582, a predicted transcriptional regulator; SMu0020,a predicted aspartate or aromatic amino acid aminotransferase; SMu1199,a predicted aspartate aminotransferase; SMu1853,a predicted trehalose operon transcriptional repressor (transcriptional regulator, GntR family); and SMu0973, a predicted transcriptional regulator, GntR family.","Mon Jan 28 14:09:14 2002","","No significant hits to the NCBI PDB database.","SMU.953c","","Residues 4 to 67 (E-value = 1.1e-09) place SMu0865 in the GntR family which is described as Bacterial regulatory proteins, gntR family (PF00392)","Mon Jan 7 11:02:43 2002","24379396","","","","","","1","","","SMU.953c","229" "SMu0866","904059","904910","852","ATGTTACCGCGTTTACTTATCGCCAATGATTTACCGGGACTTGGCAAGGTCGCTTTAGCCAGCAGTCTGCCTCTTATGGCTGCTTGCCAAGTAGAAACAGCTATTTTACCAACGGTGCTCTTATCATCACATACTGGTGGCTTCAAACAGCTTCGTATAGATGATTATACAGTAGGTATGACAGGCTTTTTAGAACAGTGGCAGAATTTAGGAATTGCTTTTGATGGTCTGGTAACTGGCTATCTCAAGAATAGTCAGCAAATAGACCTGATCTTAGAATTTGCAAATGCGAAACAGTTGCCTTTATTTGTAGATCCTATTATGGGAGATAAAGGCTGTTTTTATCAGGGATTTGATCAAGGCCATGCTAATCATATGCGACGACTATGCCAAAACGCTGACGTTATTATTCCCAATTTAACTGAAGCTGCTTTTTTAACAAAAACAGCTTATTTAGAGAAGGATTATCAGTCTAGTCAAGTCGAAAGACTGTTAAAAAAATTAGCAGCTTTAGGACCTTCTTATATTGTTTTAACAGGTGTTACTTTTGAAGCAGATAAGATTGGTTTAGCCATTTATGACCGTACAAAAGACAAGGTGGTTTACTTGATGGCTAAACATTATCCACAACATTTTTATGGTACAGGAGATATATTAACAGCAATCCTGTCTTCCGCTTATTTTAGAGGAATTTCTCTTGAGAAATCTGGTCGTCTTGCTTTGGATTTTTTGAATGAAGTCATGATGACGACCCTAGCATTAGAAAGAGATTTAAGATATGGTCTTTGTTATGAACCGCATTTACTTGATTTAATAAAGAATTATCAATTATTATTAGAGGAGAAAAAATGA","6.50","-1.74","31607","MLPRLLIANDLPGLGKVALASSLPLMAACQVETAILPTVLLSSHTGGFKQLRIDDYTVGMTGFLEQWQNLGIAFDGLVTGYLKNSQQIDLILEFANAKQLPLFVDPIMGDKGCFYQGFDQGHANHMRRLCQNADVIIPNLTEAAFLTKTAYLEKDYQSSQVERLLKKLAALGPSYIVLTGVTFEADKIGLAIYDRTKDKVVYLMAKHYPQHFYGTGDILTAILSSAYFRGISLEKSGRLALDFLNEVMMTTLALERDLRYGLCYEPHLLDLIKNYQLLLEEKK","904909","This protein phosphorylates B6 vitamins.It functions in a salvage pathway.It uses pyridoxal,pyridoxine and pyridoxamine as substrates [gi:2506917].","pyridoxal kinase","Cytoplasm, Extracellular","Several matches in gapped BLAST to pyridoxal kinase:residues 2-282 are 44% similar to the enzyme in S.pyogenes (gi|15675173|). Residues 4-268 are 29% similar to the protein from Clostridium acetobutylicum (gi|15894900|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0101 (2e-05).","

InterPro
IPR013749
Domain

Phosphomethylpyrimidine kinase type-1
PF08543	$\"[26-259]T$	Phos_pyr_kin

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.20	$\"[3-257]T$	G3DSA:3.40.1190.20
PTHR10534	$\"[2-260]T$	PTHR10534
PS51257	$\"[1-29]T$	PROKAR_LIPOPROTEIN
SSF53613	$\"[1-281]T$	SSF53613

","BeTs to 3 clades of COG2240COG name: Pyridoxal/pyridoxine/pyridoxamine kinaseFunctional Class: HThe phylogenetic pattern of COG2240 is ----Y---E--h----o----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 102-223 are 24% similar to a (PROTEOME PYRIDOXAL COMPLETE KINASE) protein domain (PD399034) which is seen in O51709_BORBU.Residues 4-91 are 34% similar to a (KINASE PYRIDOXAL PROTEOME TRANSFERASE) protein domain (PD100510) which is seen in Q9FAA3_DESVM.Residues 104-244 are 32% similar to a (KINASE TRANSFERASE PHOSPHOMETHYLPYRIMIDINE PROTEOME) protein domain (PD003501) which is seen in Q9FAA3_DESVM.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 14:09:50 2002","Mon Jan 7 14:20:48 2002","Mon Oct 14 10:17:46 2002","Mon Jan 7 14:04:31 2002","","Mon Jan 7 14:04:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0866 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 14:05:34 2002","","No significant hits to the NCBI PDB database.","SMU.954","","No significant hits to the Pfam 11.0 database","Mon Jan 7 14:04:31 2002","24379397","","","Yang,Y., Zhao,G. and Winkler,M.E.Identification of the pdxK gene that encodes pyridoxine (vitaminB6) kinase in Escherichia coli K-12FEMS Microbiol. Lett. 141 (1), 89-95 (1996)PubMed: 8764513Yang,Y., Tsui,H.C., Man,T.K. and Winkler,M.E.Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12J. Bacteriol. 180 (7), 1814-1821 (1998)PubMed: 9537380","","Mon Oct 14 10:17:46 2002","1","","","SMU.954","" "SMu0867","904907","905440","534","ATGAAAAAAGAAGAGTTACGTCGTTTGATAGAAGTGAGTTTATTTGCAGCCTTGATTTTAGTCAGTGTTCAATTTCTGCGTATTCAGGTGGGACCGCAGTTTGTTCATTTGGGCAATGCCTTAGTGGTTATCGCTGTTCTTGTTTTTGGTTCAGGTTTTGGTGCTTTAGCAGCTGCACTTGGTTTGGGACTTTTTGATATTTTCAACGGTTATGCGGCAGAAGTTTGGATAACTATTTTAGAATCACTGCTTGTTTGCTATGTTTTGCATTTAGTTTATGAGAAAGCGATGAAAGCCAATGATAAACCGGCAACTATTTTTACTGTTGGACTAGTTGCTGCGGTAACGAAGATTATTCTCAATCTTTTTAAATATACTCTGATTAACAGTTTCATTGGTGGCTTAGCTCTACTTCCAGCAATGGTAGGAGCCTTGGCTAAAATTACAGGTACTTTTGGAACTTCGATTGTTACCATTGTAGCTGTTCCTATACTTTATCCCATTTTTAAACGGATTGTCCAAGGTAAAAATTAA","10.40","6.42","19019","MKKEELRRLIEVSLFAALILVSVQFLRIQVGPQFVHLGNALVVIAVLVFGSGFGALAAALGLGLFDIFNGYAAEVWITILESLLVCYVLHLVYEKAMKANDKPATIFTVGLVAAVTKIILNLFKYTLINSFIGGLALLPAMVGALAKITGTFGTSIVTIVAVPILYPIFKRIVQGKN","905439","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypothetical protein:residues 1-172 are 51% similar to the protein in S.pyogenes (gi|15675172|). Residues 7-172 are 54% similar to the protein from S.gordonii (gi|15991792|). SMu0867 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-25]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[40-60]?$ $\"[75-93]?$ $\"[103-123]?$ $\"[125-145]?$ $\"[151-169]?$	transmembrane_regions

InterPro
IPR001270
Family

Chaperonin clpA/B
PR00300	$\"[449-467]T$ $\"[494-512]T$ $\"[524-542]T$ $\"[557-571]T$	CLPPROTEASEA
PS00871	$\"[479-497]T$	CLPAB_2

InterPro
IPR002078
Domain

RNA polymerase sigma factor 54, interaction
PS50045	$\"[418-671]T$	SIGMA54_INTERACT_4

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[114-260]T$ $\"[445-588]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[117-271]T$	AAA

InterPro
IPR013093
Domain

ATPase AAA-2
PF07724	$\"[444-605]T$	AAA_2

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.60	$\"[611-698]T$	G3DSA:1.10.8.60
G3DSA:3.40.50.300	$\"[73-269]T$ $\"[397-610]T$	G3DSA:3.40.50.300
PTHR11638	$\"[12-547]T$	PTHR11638
PTHR11638:SF19	$\"[12-547]T$	PTHR11638:SF19

","BeTs to 14 clades of COG0542COG name: ATPases with chaperone activity, ATP-binding domainFunctional Class: OThe phylogenetic pattern of COG0542 is --t-YQVCEBRhUJgpOLINxNumber of proteins in this genome belonging to this COG is 4","***** IPB001270 (Chaperonins clpA/B) with a combined E-value of 2.1e-180. IPB001270A 96-138 IPB001270B 139-187 IPB001270C 188-202 IPB001270D 231-285 IPB001270E 425-479 IPB001270F 507-561 IPB001270G 594-608 IPB001270H 652-666 IPB001270A 427-469***** IPB001943 (UvrB/uvrC motif) with a combined E-value of 8.5e-06. IPB001943B 109-118 IPB001943C 338-365 IPB001943C 252-279","Residues 229-306 are 67% similar to a (PROTEASE ATP-BINDING PROTEOME COMPLETE ATP-DEPENDENT) protein domain (PD001382) which is seen in CLPL_LACLA.Residues 444-548 are 62% similar to a (COMPLETE PROTEOME SECRETION TYPE PLASMID ATP-BINDING) protein domain (PD000739) which is seen in CLPB_HELPJ.Residues 144-196 are 73% similar to a (PROTEASE ATP-BINDING SHOCK HEAT COMPLETE PROTEOME) protein domain (PD187342) which is seen in CLPL_LACLA.Residues 336-437 are 33% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in CLPB_SYNY3.Residues 67-143 are 62% similar to a (PROTEASE ATP-BINDING COMPLETE SHOCK HEAT PROTEOME) protein domain (PD002024) which is seen in Q9S6T8_STRCO.Residues 380-673 are 52% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9PQ99_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 10:18:55 2002","Mon Jan 7 14:44:08 2002","Mon Oct 14 10:18:55 2002","Mon Jan 7 14:42:47 2002","Mon Jan 7 14:42:47 2002","Mon Jan 7 14:42:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0868 is paralogously related (blast p-value < 1e-3) to SMu0511,a predicted ATP-dependent protease ClpE, SMu1844,apredicted ATP-dependent Clp protease, ATP-binding subunit (Class III stress response-related ATPase) SMu1300,a predicted ATP-dependent Clp protease,ATP-binding chain B (ClpB), SMu0861,a predicted ATP-dependent Clp protease subunit X, SMu1866,a predicted chromosome segregation helicase and SMu0013, a predicted cell division protein FtsH.","Mon Jan 14 11:21:13 2002","","No significant hits to the NCBI PDB database.","SMU.956c","","Residues 117 to 322 (E-value = 4.8e-14) place SMu0868 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)Residues 448 to 671 (E-value = 1.8e-05) place SMu0868 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)","Mon Jan 7 14:42:47 2002","","","Gottesman S, Squires C, Pichersky E, Carrington M, Hobbs M, Mattick JS, Dalrymple B, Kuramitsu H, Shiroza T, Foster T, et alConservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.Proc Natl Acad Sci U S A. 1990 May;87(9):3513-7.PubMed: 2185473PMID: 2185473 ","Huang,D.C., Huang,X.F., Novel,G. and Novel,M.Two genes present on a transposon-like structure in Lactococcuslactis are involved in a Clp-family proteolytic activityMol. Microbiol. 7 (6), 957-965 (1993)PubMed: 8387149Ingmer,H., Vogensen,F.K., Hammer,K. and Kilstrup,M.Disruption and analysis of the clpB, clpC, and clpE genes inLactococcus lactis: ClpE, a new clp family in gram-positivebacteriaJ. Bacteriol. 181 (7), 2075-2083 (1999)PubMed: 10094684Steiner K, Malke H.relA-Independent amino acid starvation response network of Streptococcus pyogenes.J Bacteriol. 2001 Dec;183(24):7354-64.PMID: 11717294Chastanet A, Prudhomme M, Claverys JP, Msadek T.Regulation of Streptococcus pneumoniae clp genes and their role in competence development and stress survival.J Bacteriol. 2001 Dec;183(24):7295-307.PMID: 11717289 Skinner MM, Trempy JE.Expression of clpX, an ATPase subunit of the Clp protease, is heat and cold shock inducible in Lactococcus lactis.J Dairy Sci. 2001 Aug;84(8):1783-5.PMID: 11518300 Frees D, Varmanen P, Ingmer H.Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation of non-native proteins and concomitantly increases stress tolerance in Lactococcus lactis.Mol Microbiol. 2001 Jul;41(1):93-103.PMID: 11454203 ","Wed Mar 27 11:24:48 2002","Wed Mar 27 10:59:06 2002","1","","","SMU.956c","138" "SMu0869","907994","908497","504","ATGAGTGAAGCAAGTATTGCTAAAAAAGCAGAATTAGTTGATGCTGTTGCTGAGAAAATGAAAGCAGCTGTAAGTATCGTCGTTGTTGATTCACGTGGTCTTACTGTTGAACAAGATACTGTTCTTCGTCGTAACTTGCGTGAAAGTGCTGTTGAATTCAAAGTTATCAAGAATTCAATCTTACGTCGTGCTGCTGAAAAAGCTGGTCTTGAAGGATTTGATGATATCTTTACTGGACCATCAGCTGTTGCATTTTCAAATGAAGATGTTGTGGCACCAGCTAAAATTATTAACGATTTTGCTAAAGATGCTGAAGCACTTGAAATCAAAGGCGGTGCAATCGAAGGTGCTGTTTCTACAAAAGAAGAAATTCAAGCTCTCGCAGCACTTCCAAACAGAGAAGGACTTCTTTCTATGCTCTTGTCTGTACTTCAAGCGCCAGTCCGCAACGTTGCATATGCTGTCAAAGCTGTTGCAGAAAGCAAAGACGAAGACGCCGCTTAA","4.70","-5.99","17651","MSEASIAKKAELVDAVAEKMKAAVSIVVVDSRGLTVEQDTVLRRNLRESAVEFKVIKNSILRRAAEKAGLEGFDDIFTGPSAVAFSNEDVVAPAKIINDFAKDAEALEIKGGAIEGAVSTKEEIQALAALPNREGLLSMLLSVLQAPVRNVAYAVKAVAESKDEDAA","908496","For other 'rpl' genes see SMu0639 (rplT); SMu0771 (rplU); SMu0152 (rplM); SMu1941 (rplI); SMu0872 (rpl); SMu1175 (rplS); SMu1480 (rplA) and SMu1481 (rplK).Stated by ajdic et al., 2002, to be a cold-shock protein.","50S ribosomal protein L10","Cytoplasm","Several matches in gapped BLAST to 50S ribosomal protein L10:residues 1-167 are 85% similar to the protein in S.pneumoniae (gi|15901209|). Residues 1-163 are 83% similar to the protein from S.pyogenes (gi|15675064|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1302 (1e-67).","

InterPro
IPR001790
Family

Ribosomal protein L10
PF00466	$\"[4-102]T$	Ribosomal_L10

InterPro
IPR002363
Family

Eubacterial ribosomal protein L10
PS01109	$\"[9-43]T$	RIBOSOMAL_L10

","BeTs to 15 clades of COG0244COG name: Ribosomal protein L10Functional Class: JThe phylogenetic pattern of COG0244 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002363 (Eubacterial ribosomal protein L10) with a combined E-value of 4.2e-45. IPB002363A 16-66 IPB002363B 89-104 IPB002363C 109-147***** IPB001790 (Ribosomal protein L10) with a combined E-value of 6.1e-13. IPB001790A 33-64 IPB001790B 109-130 IPB001790C 137-152","Residues 9-111 are 33% similar to a (RIBOSOMAL 50S) protein domain (PD234102) which is seen in RL10_TREPA.Residues 7-121 are 80% similar to a (RIBOSOMAL 50S L8 REGULATION) protein domain (PD353016) which is seen in RL10_STRPY.Residues 122-163 are 90% similar to a (RIBOSOMAL 50S VEGETATIVE BL5) protein domain (PD402661) which is seen in RL10_STRPY.Residues 9-102 are 40% similar to a (RIBOSOMAL 50S) protein domain (PD235606) which is seen in RL10_UREPA.Residues 8-158 are 29% similar to a (RIBOSOMAL 50S) protein domain (PD407734) which is seen in RL10_CHLTR.Residues 5-163 are 25% similar to a (RIBOSOMAL 50S L10) protein domain (PD399036) which is seen in RL10_BUCAI.Residues 2-122 are 31% similar to a (RIBOSOMAL 50S) protein domain (PD094991) which is seen in RL10_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 20:16:18 2002","Wed Apr 24 11:35:14 2002","Mon Oct 14 10:20:13 2002","Mon Jan 7 14:57:04 2002","Mon Jan 7 14:57:04 2002","Mon Jan 7 14:57:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0869 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 14:57:17 2002","","No significant hits to the NCBI PDB database.","SMU.957","","Residues 4 to 102 (E-value = 2.8e-28) place SMu0869 in the Ribosomal_L10 family which is described as Ribosomal protein L10 (PF00466)","Mon Jan 7 14:57:04 2002","24379400","","","Dovgas,N.V., Vinokurov,L.M., Velmoga,I.S., Alakhov,Y.B. andOvchinnikov,Y.A.The primary structure of protein L10 from Escherichia coliribosomesFEBS Lett. 67 (1), 58-61 (1976)PubMed: 782920Heiland,I., Brauer,D. and Wittmann-Liebold,B.Primary structure of protein L10 from the large subunit ofEscherichia coli ribosomesHoppe-Seyler's Z. Physiol. Chem. 357 (12), 1751-1770 (1976)PubMed: 797648Post,L.E., Strycharz,G.D., Nomura,M., Lewis,H. and Dennis,P.P.Nucleotide sequence of the ribosomal protein gene cluster adjacentto the gene for RNA polymerase subunit beta in Escherichia coliProc. Natl. Acad. Sci. U.S.A. 76 (4), 1697-1701 (1979)PubMed: 377281Arnold,R.J. and Reilly,J.P.Observation of Escherichia coli ribosomal proteins and theirposttranslational modifications by mass spectrometryAnal. Biochem. 269 (1), 105-112 (1999)PubMed: 10094780","","Sun Oct 27 20:16:18 2002","1","","","SMU.957","692" "SMu0870","908214","908534","321","ATGATATCTTTACTGGACCATCAGCTGTTGCATTTTCAAATGAAGATGTTGTGGCACCAGCTAAAATTATTAACGATTTTGCTAAAGATGCTGAAGCACTTGAAATCAAAGGCGGTGCAATCGAAGGTGCTGTTTCTACAAAAGAAGAAATTCAAGCTCTCGCAGCACTTCCAAACAGAGAAGGACTTCTTTCTATGCTCTTGTCTGTACTTCAAGCGCCAGTCCGCAACGTTGCATATGCTGTCAAAGCTGTTGCAGAAAGCAAAGACGAAGACGCCGCTTAAGTCTTCAAACAGTAGCATAGTGCTACAAATTATTTAA","11.10","17.32","12524","MISLLDHQLLHFQMKMLWHQLKLLTILLKMLKHLKSKAVQSKVLFLQKKKFKLSQHFQTEKDFFLCSCLYFKRQSATLHMLSKLLQKAKTKTPLKSSNSSIVLQII","908533","","hypothetical protein","Cytoplasm","No hits in gapped BLAST found.SMu0870 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-36]?$	signal-peptide

noIPR
unintegrated

unintegrated
signalp	$\"[1-20]?$	signal-peptide

InterPro
IPR000206
Family

Ribosomal protein L7/L12
TIGR00855	$\"[1-122]T$	L12

InterPro
IPR008932
Domain

Ribosomal protein L7/L12, oligomerisation
SSF48300	$\"[3-58]T$	Ribosomal_L12/7

InterPro
IPR013823
Domain

Ribosomal protein L7/L12, C-terminal
PD001326	$\"[64-122]T$	Ribosomal_L12
PF00542	$\"[56-122]T$	Ribosomal_L12

InterPro
IPR014719
Domain

Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
G3DSA:3.30.1390.10	$\"[49-122]T$	Ribosomal_L7/12_C/ClpS-like

noIPR
unintegrated

unintegrated
PTHR11809	$\"[4-122]T$	PTHR11809
SSF54736	$\"[55-122]T$	SSF54736

","BeTs to 12 clades of COG0222COG name: Ribosomal protein L7/L12Functional Class: JThe phylogenetic pattern of COG0222 is ----yqvCebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000206 (Ribosomal protein L7/L12 C-terminal domain) with a combined E-value of 7.8e-54. IPB000206A 6-37 IPB000206B 51-66 IPB000206C 67-119","Residues 56-122 are 52% similar to a (RIBOSOMAL 50S L7/L12 CHLOROPLAST PEPTIDE TRANSIT) protein domain (PD001326) which is seen in RL7_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 10:21:08 2002","Mon Jan 7 15:12:29 2002","Mon Oct 14 10:21:08 2002","Mon Jan 7 15:11:24 2002","Mon Jan 7 15:11:24 2002","Mon Jan 7 15:11:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0872 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 15:12:29 2002","Mon Jan 7 15:11:24 2002","pdb|1DD3|A Chain A, Crystal Structure Of Ribosomal Protein L12 ... 86 2e-018","SMU.960","","Residues 56 to 122 (E-value = 9.6e-32) place SMu0872 in the Ribosomal_L12 family which is described as Ribosomal protein L7/L12 C-terminal domain (PF00542)","Mon Jan 7 15:11:24 2002","24379403","","","Terhorst,C., Moller,W., Laursen,R. and Wittmann-Liebold,B.The primary structure of an acidic protein from 50-S ribosomes ofEscherichia coli which is involved in GTP hydrolysis dependent onelongation factors G and TEur. J. Biochem. 34 (1), 138-152 (1973)PubMed: 4573678Post,L.E., Strycharz,G.D., Nomura,M., Lewis,H. and Dennis,P.P.Nucleotide sequence of the ribosomal protein gene cluster adjacentto the gene for RNA polymerase subunit beta in Escherichia coliProc. Natl. Acad. Sci. U.S.A. 76 (4), 1697-1701 (1979)PubMed: 377281Pettersson,I., Hardy,S.J. and Liljas,A.The ribosomal protein L8 is a complex L7/L12 and L10FEBS Lett. 64 (1), 135-138 (1976)PubMed: 773698","","Mon Jan 7 15:17:56 2002","1","","","SMU.960","819" "SMu0873","909198","909749","552","ATGTCTAAATTTACTATACATACAATTGAAACTGCACCCGAGAGAGTTAAAGAAACGTTGCGGACAGTTAAAAAGGACAATGGCGGCTATATACCTAATCTTATTGGCCTTTTGGCTAATGCCCCAACGGCTCTTGAGACTTATCGGACAGTAGGAGAAATTAATCGTCGTAATTCATTAACACCAACGGAGCGCGAAGTTGTTCAGATTACAGCTGCTGTAACCAATGGCTGTGCTTTTTGTGTAGCAGGTCATACAGCCTTTTCGATTAAGCAAATTCAAATGGCACCAGATTTATTAGAGGCCTTGCGCAATGCAACTCCGATCGATGATGATCCTAAGTTGGATACCTTGGCAAAATTTACTATTGCTGTTATTAACACCAAGGGACGTGTCGGAGATGAAGCTTTTGCTGATTTCTTGGAAGTTGGTTATACGCCTGAGAATGCGCTTGATGTGGTTTTGGGTGTTAGTTTAGCCTCGCTTTGCAATTATGCCAATAATATGGCAGACACACCAATTAACCCAGAGTTACAGCAGTATGTGAAATAG","4.90","-4.66","19895","MSKFTIHTIETAPERVKETLRTVKKDNGGYIPNLIGLLANAPTALETYRTVGEINRRNSLTPTEREVVQITAAVTNGCAFCVAGHTAFSIKQIQMAPDLLEALRNATPIDDDPKLDTLAKFTIAVINTKGRVGDEAFADFLEVGYTPENALDVVLGVSLASLCNYANNMADTPINPELQQYVK","909748","","macrophage infectivity potentiator-related protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical protein:residues 1-181 are 79% similar to the protein in S.pneumoniae (gi15900328).Residues 4-181 are 69% similar to the protein from S.suis (gi17154760). SMu0873 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003779
Domain

Carboxymuconolactone decarboxylase
PF02627	$\"[42-124]T$	CMD

InterPro
IPR004675
Domain

Alkylhydroperoxidase AhpD core
TIGR00778	$\"[58-108]T$	ahpD_dom

noIPR
unintegrated

unintegrated
SSF69118	$\"[1-115]T$	SSF69118

","BeTs to 3 clades of COG0599COG name: Uncharacterized ACR, homolog of gamma-carboxymuconolactone decarboxylase subunitFunctional Class: SThe phylogenetic pattern of COG0599 is AMT---Vc-brh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 38-167 are 27% similar to a (MACROPHAGE PROTEOME INFECTIVITY COMPLETE) protein domain (PD033852) which is seen in Q53427_LEGPN.Residues 1-181 are 50% similar to a (COMPLETE PROTEOME MACROPHAGE) protein domain (PD358447) which is seen in Q9JUP9_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 00:12:10 2002","Thu Feb 22 14:09:12 2007","Thu Feb 22 14:07:54 2007","Mon Jan 7 15:21:53 2002","","Mon Jan 7 15:21:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0873 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 28 00:12:10 2002","","No significant hits to the NCBI PDB database.","SMU.961","","No significant hits to the Pfam 11.0 database","Mon Jan 7 15:21:53 2002","24379404","","","","","","1","","","SMU.961","" "SMu0874","909770","910837","1068","ATGGCTTATTTTTCGGGAGAATTTATTGATTGGTTAGATACTCATGCTGATCAGATTGACCAAAAGTCTGGCGGAGCAGCTGACCAACTATTAGAAAAAGTAGCAGCGGAAGGTGTTTTTGGTCTTGCTGTTCCAGAGAAATCTGGGGGTAAGGGTGGTTCTCAAACAGAGGTTATTGGATTTTTGTCAGAATTAGCGCAGCATTCTTTAACGGCTTCCTTTATCTCATGGGGACATCGAACCTTTATCGAAAATATTCTTGCAAGCAGTAACGACTATGCTAGAAAGACTTGGCTGCCTGATTTGTTAACAGGGAAATTAGCAGCCGGGACAGCTCTGTCAAATGCGACAAAATTCTTATCTAAAATTGAAGAATTGAATGTTACTATCATTGAGCAAGAGGGACAGTATTACCTTAAAGGCAGATTACCTTGGGTGACTAATTTGCGTTCTGATAATTTCGTTACTATTTTTGCGGCTTCTTTTGAAGACGAAAATAAAAAACCTTTAATTTTGACAGTGCCATCAACAGCAGCACACCTATCACGCTCTGATGATTTAGAATTTGTTTCTTTGCAGGGTTCTAACACAGCAGCTCTCACATTTAATCGCGTTCCTTTGGATAATAACTGGATTTTATCAGATGATGCTGAAGACTTCTTGGCTCAGACGCGTCCGGAATTTCTAGGCTACCAATTTGGTCTTGCTTTTGGTTTAGCGGAGCGTTCCTTAAAAGAAGTTGCGCAAAATCTTAACAGCAATCGTTCAGTTCTGAGAACAGAATATGATAATGTTTTGAAAGATCTCAATACCATTAAGAGTGACTTGTTTGAAGGTCTAGGTGATCGTACCTACTTCATTAGAAATCCGCGGCAGCTTTTTCAGTTACGCATTGATATCGTAGATATTGTAGCCAATAGTTTGCTGCTGGAATTGCAGGCAAGCGGCGGTCGCGGGTATTTTAAACATTCAACATCAAGTTTTATTCGCCGTTGGAATGAAGGGGCTTTTCTGCCGATAGTTTCCCCAAGTGCAGTTCAGCTTCGACATATTTTGGAAACTGTTTAG","5.00","-9.53","39435","MAYFSGEFIDWLDTHADQIDQKSGGAADQLLEKVAAEGVFGLAVPEKSGGKGGSQTEVIGFLSELAQHSLTASFISWGHRTFIENILASSNDYARKTWLPDLLTGKLAAGTALSNATKFLSKIEELNVTIIEQEGQYYLKGRLPWVTNLRSDNFVTIFAASFEDENKKPLILTVPSTAAHLSRSDDLEFVSLQGSNTAALTFNRVPLDNNWILSDDAEDFLAQTRPEFLGYQFGLAFGLAERSLKEVAQNLNSNRSVLRTEYDNVLKDLNTIKSDLFEGLGDRTYFIRNPRQLFQLRIDIVDIVANSLLLELQASGGRGYFKHSTSSFIRRWNEGAFLPIVSPSAVQLRHILETV","910836","","acyl-CoA dehydrogenase","Cytoplasm","Limited matches in gapped BLAST to acyl-CoA dehydrogenase:residues 16-245 are 22% similar to the protein in B.subtilis (gi|16079471|). Residues 17-349 are 24% similar to the protein from N.meningitidis (gi|15676885|). SMu0874 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR009100
Domain

Acyl-CoA dehydrogenase/oxidase, middle and N-terminal
SSF56645	$\"[2-216]T$	AcylCoA_dehyd_NM

InterPro
IPR013786
Domain

Acyl-CoA dehydrogenase/oxidase, N-terminal
G3DSA:1.10.540.10	$\"[4-108]T$	AcylCoA_DH/ox_N

","BeTs to 3 clades of COG1960COG name: Acyl-CoA dehydrogenasesFunctional Class: IThe phylogenetic pattern of COG1960 is A-------EBR----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 30-353 are 44% similar to a (PROTEOME COMPLETE DEHYDROGENASE ACYL-COA) protein domain (PD333174) which is seen in Q9I1E8_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 10:26:24 2002","Mon Jan 28 14:16:18 2002","Mon Oct 14 10:26:24 2002","Mon Jan 7 15:23:23 2002","","Mon Jan 7 15:23:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0874 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 15:25:37 2002","Mon Jan 7 15:23:23 2002","pdb|1IVH|A Chain A, Structure Of Human Isovaleryl-Coa Dehydroge... 230 2e-061","SMU.962","","No significant hits to the Pfam 11.0 database","Mon Jan 7 15:23:23 2002","24379405","","","Zhang YX, Denoya CD, Skinner DD, Fedechko RW, McArthur HA,Morgenstern MR, Davies RA, Lobo S, Reynolds KA, Hutchinson CR.Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production.Microbiology. 1999 Sep;145 ( Pt 9):2323-34.PMID: 10517585 Mohsen AW, Navarette B, Vockley J.Identification of Caenorhabditis elegans isovaleryl-CoA dehydrogenase and structural comparison with other acyl-CoA dehydrogenases.Mol Genet Metab. 2001 Jun;73(2):126-37.PMID: 11386848 ","","Mon Jan 7 15:44:05 2002","1","","","SMU.962","" "SMu0875","912328","911429","900","ATGACTAAGAAAAAACATCAAAAGAAATCATTAACAGGTCTTAATGCCATTTTAATTTTTGCCTGTGCTTTAATATTAGGTTTTCTCCTTTTTGTAGTAACCTACCAAAAAAAGACAGCAACTAAAAGTAGAACTACAACTACTACTGTAACCAGCATTACTAAAAGCAGCCATCAAAAAAAAGAAAAAACAAACAGCAAATGGGCCAAACAAGATCAGCCAGTTAAAATCCCTATTTTAATGTATCACGCTATCCATAACATGGCTCCAGAGGAAGCAGGAAATGCCAATCTCATTGTTGCTCCCGATATTTTTGAAAGTCATATTAAACGTTTGAGCGACGAGGGTTACTACTTTTTAACTCCAGAAGAAGCTTACAAAGCTCTTACTCAAAACAGTCTGCCTGCTAAAAAAGTGATTTGGCTGACTTTTGATGACAGTCTTATTGACTTTTATAATATTGCCTTCCCTATCTTAAAAAAATATAAAGCCAAGGCCACCAATAATGTTATTACCAGTTTCACTCAGGAGGGAAGAGCTGGAAACCTAACGTTAAAGCAAATGAAAGAAATGAAAAAGGAAGGAATGTCTTTCCAATCTCATACTCTGACCCATCCTGATTTATCTGCTTCAGATCAAGAAACGCAGGCTGCAGAGCTAAAGCAATCTAAGGATTATCTCGATAAAGAATTAGATCAAACCACAACAGCAATAGCTTATCCAGCGGGACGTTACAATGATACAACGCTTAATTTAGCTAATCAATATAAGTTGGGAGTGACAACTAACGAAGGCCTAGCTAGTGCTAACGATGGACTTCTCTCCTTAAATCGTATCCGCATCCTACCAGATACAAGTGCAGATGTTTTAATAAATACTATCTCTCCTGCCATTCAGTAA","10.10","9.64","33353","MTKKKHQKKSLTGLNAILIFACALILGFLLFVVTYQKKTATKSRTTTTTVTSITKSSHQKKEKTNSKWAKQDQPVKIPILMYHAIHNMAPEEAGNANLIVAPDIFESHIKRLSDEGYYFLTPEEAYKALTQNSLPAKKVIWLTFDDSLIDFYNIAFPILKKYKAKATNNVITSFTQEGRAGNLTLKQMKEMKKEGMSFQSHTLTHPDLSASDQETQAAELKQSKDYLDKELDQTTTAIAYPAGRYNDTTLNLANQYKLGVTTNEGLASANDGLLSLNRIRILPDTSADVLINTISPAIQ","911434","","polysaccharide deacetylase family protein","Extracellular, Membrane","Limited matches in gapped BLAST to conserved hypothetical protein :residues 3-296 are 56% similar to the protein in S.pyogenes (gi15675078).Residues 66-297 are 41% similar to the protein from Lactococcus lactis subsp. lactis (gi15672087). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1121 (8e-88).","

InterPro
IPR002509
Domain

Polysaccharide deacetylase
PF01522	$\"[133-261]T$	Polysacc_deac_1

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.370	$\"[102-258]T$	G3DSA:3.20.20.370
PS51257	$\"[1-22]T$	PROKAR_LIPOPROTEIN
SSF88713	$\"[96-258]T$	SSF88713

","BeTs to 4 clades of COG0726COG name: Predicted xylanase/chitin deacetylaseFunctional Class: GThe phylogenetic pattern of COG0726 is ----Y-vcEBr-uj-------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 73-197 are 45% similar to a (COMPLETE PROTEOME ICAB PRECURSOR) protein domain (PD009376) which is seen in P94361_BACSU.Residues 200-281 are 51% similar to a (PROTEOME COMPLETE S ISSPROT:YADE_ECOLI) protein domain (PD081797) which is seen in Q9CJ95_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 00:12:43 2002","Wed Aug 30 15:16:14 2006","Wed Aug 30 15:16:14 2006","Mon Jan 7 15:51:44 2002","","Mon Jan 7 15:51:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0875 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 28 00:12:43 2002","","No significant hits to the NCBI PDB database.","SMU.963c","","Residues 133 to 261 (E-value = 5.2e-35) place SMu0875 in the Polysacc_deac_1 family which is described as Polysaccharide deacetylase (PF01522)","Mon Jan 7 15:51:44 2002","24379406","","","","","","1","","","SMU.963c","568" "SMu0876","912434","913720","1287","ATGTCTATAAAAATTGGTTTGCTTGGGTTTGGTACAGTAGCGAGCGGAATGCCGTTTTTATTGAAGGAAAACAAGGATAAAATTACAGCTGCTTCAGGGACTAAACTTGAAATTGCTAAAGTTTTGGTTAAAGACGACGATGAGAAAAAACGTCTTTTGGCAGCGGGCAATGATTTTAACTTTGTAACGAATGTTGATGATATTTTGTCCGATGACGATATTGCTATTGTTGTGGAATTGATGGGACGCATTGAACCAGCTAAGACTTTTATCACCAAGGCGCTTGAAGCTGGTAAGCATGTTGTTTCAGCTAATAAAGACTTAATTGCAACGCATGGTAAAGAACTCATCAGACTTGCTCAAGATAAAGGTGTAGCTTTTTATTATGAGGCTGCTGTTGCTGGTGGTATTCCGATTTTACGCACTTTAGCCAATTCATTGACTTCTGATAAGGTCACTCGTATTCTTGGAGTATTAAACGGAACCTCTAATTTTATGATGACCAAAATGGTCGATGAAGGCTGGACCTATGAAGCGGCTCTCAAAAAAGCTCAGGAATTAGGTTATGCTGAAAGCGATCCGACCAATGATGTTGAAGGAATTGATGCAGCTTATAAGGCTGTTATTCTCAGCCAATTTGGTTTTGGCATGACAATTGATTTTGATCAAGTAGTGCATCAAGGTATTTCAAGCATTACTCCTGATGATGTCGCTATGGCACAGCAACTAGGTTATGTTATCAAGCTGGTTGGTTCAGTTGAGGAAACACCTTCTGGTATTTTTGCAGAAGTGTCACCTACATTCCTTCCAAAATCTCATCCGCTTGCCAGTGTTAATGATGTGATGAATGCAGTCTTTGTGGAATCAATTGGTATTGGTGAGTCTATGTACTATGGACCGGGTGCCGGTCAAAAGCCAACAGCAACCTCTGTTGTAGCTGATGTGATTCGCATCGCTCGTCGCATCAAAGACGGTAATGTCGGTAAATGCTTCAATGAATTTATCCGTGAAACAAAAATTGCGCATCCTGATGATGTTAAAAGTCATTATTATTTTGCTATTAATACAGCAGATGAAAAAGGTAAAATGCTGCGCTTGGCGGAAATTTTCAATTCAGAAGATATCTCTTTTGAACAAGTTTTACAGCAAAAAGCTAATGGTGAACAAGCGCGTGTGGTGATAATTACGCATTCATTGAGTAAGAGCCAGTTAGTAAATGTCACTGAGAAATTACAAGCTGTGGCAGACTTTAAATTGCTCAACACTTTCAAAGTATTAGGGGAATAA","5.20","-9.33","46408","MSIKIGLLGFGTVASGMPFLLKENKDKITAASGTKLEIAKVLVKDDDEKKRLLAAGNDFNFVTNVDDILSDDDIAIVVELMGRIEPAKTFITKALEAGKHVVSANKDLIATHGKELIRLAQDKGVAFYYEAAVAGGIPILRTLANSLTSDKVTRILGVLNGTSNFMMTKMVDEGWTYEAALKKAQELGYAESDPTNDVEGIDAAYKAVILSQFGFGMTIDFDQVVHQGISSITPDDVAMAQQLGYVIKLVGSVEETPSGIFAEVSPTFLPKSHPLASVNDVMNAVFVESIGIGESMYYGPGAGQKPTATSVVADVIRIARRIKDGNVGKCFNEFIRETKIAHPDDVKSHYYFAINTADEKGKMLRLAEIFNSEDISFEQVLQQKANGEQARVVIITHSLSKSQLVNVTEKLQAVADFKLLNTFKVLGE","913719","This enzyme is involved in threonine biosynthesis and part ofmethionine biosynthetic pathway. It leads to reduction of aspartate semialdehyde to homoserine [gi:2117450].","homoserine dehydrogenase","Cytoplasm","Several matches in gapped BLAST to homoserine dehydrogenase: residues 1-428 are 73% similar to the protein in S.pneumoniae (gi|15903262|) and are 62% similar to the protein from Lactococcus lactis (gi|1706417|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1120 (1e-133).","

InterPro
IPR001342
Domain

Homoserine dehydrogenase, catalytic
PF00742	$\"[138-316]T$	Homoserine_dh
PS01042	$\"[184-206]T$	HOMOSER_DHGENASE

InterPro
IPR005106
Domain

Homoserine dehydrogenase, NAD-binding
PF03447	$\"[9-130]T$	NAD_binding_3

noIPR
unintegrated

unintegrated
G3DSA:3.30.360.10	$\"[148-289]T$	G3DSA:3.30.360.10
PIRSF000098	$\"[1-428]T$	Homoser_dehydrog
PTHR21499	$\"[66-414]T$	PTHR21499
PTHR21499:SF2	$\"[66-414]T$	PTHR21499:SF2
SSF51735	$\"[3-159]T$	SSF51735
SSF55021	$\"[339-423]T$	SSF55021
SSF55347	$\"[138-303]T$	SSF55347

","BeTs to 12 clades of COG0460COG name: Homoserine dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0460 is amTkyqvcEbrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001342 (Homoserine dehydrogenase) with a combined E-value of 6.6e-48. IPB001342A 3-24 IPB001342B 129-140 IPB001342C 157-167 IPB001342D 184-212 IPB001342E 296-315","Residues 324-428 are 54% similar to a (BIOSYNTHESIS NADP ISOLEUCINE HOMOSERINE) protein domain (PD131613) which is seen in DHOM_LACLA.Residues 337-411 are 28% similar to a (BIOSYNTHESIS DEHYDROGENASE OXIDOREDUCTASE) protein domain (PD005892) which is seen in DHOM_BACSU.Residues 3-162 are 60% similar to a (BIOSYNTHESIS DEHYDROGENASE HOMOSERINE OXIDOREDUCTASE) protein domain (PD002589) which is seen in DHOM_LACLC.Residues 164-323 are 70% similar to a (BIOSYNTHESIS DEHYDROGENASE HOMOSERINE OXIDOREDUCTASE) protein domain (PD328790) which is seen in DHOM_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 21 08:58:46 2002","Mon Jan 7 15:55:08 2002","Mon Oct 14 10:33:08 2002","Mon Jan 7 15:55:08 2002","Mon Jan 7 15:55:08 2002","Mon Jan 7 15:55:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0876 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 15:55:58 2002","Mon Jan 7 15:55:08 2002","pdb|1EBF|A Chain A, Homoserine Dehydrogenase From S. Cerevisiae... 77 4e-015","SMU.965","","Residues 2 to 136 (E-value = 8.8e-47) place SMu0876 in the NAD_binding_3 family which is described as Homoserine dehydrogenase, NAD binding domain (PF03447)Residues 138 to 316 (E-value = 1.9e-90) place SMu0876 in the Homoserine_dh family which is described as Homoserine dehydrogenase (PF00742)","Mon Jan 7 15:55:08 2002","24379407","","","Madsen,S.M., Albrechtsen,B., Hansen,E.B. and Israelsen,H.Cloning and transcriptional analysis of two threonine biosyntheticgenes from Lactococcus lactis MG1614J. Bacteriol. 178 (13), 3689-3694 (1996)PubMed: 8682767Parsot,C. and Cohen,G.N.Cloning and nucleotide sequence of the Bacillus subtilis hom genecoding for homoserine dehydrogenase. Structural and evolutionaryrelationships with Escherichia coli aspartokinases-homoserinedehydrogenases I and IIJ. Biol. Chem. 263 (29), 14654-14660 (1988)PubMed: 3139660","","Mon Jan 7 15:59:29 2002","1","","","SMU.965","380" "SMu0877","913722","914588","867","ATGAAAATTACAGTACCTGCAACATCAGCTAATATTGGACCCGGCTTTGACTCTGTCGGTGTTGCTCTTTCCAAATATCTTTCTATTGAAGTTTTAGAAGAAGCTGCTTCTTGGCATATTAGTCATGATTTGGGTGATATTCCAAGTGATGAGCATAATTTGTTGCTTGTAACAGCTTTAAAAGTGGCACCAGATCTCAGACCTCATCGCTTACGTATGGTTAGTGACATTCCTCTGGCAAGAGGATTAGGATCGTCAAGCTCTGTTATTGTTGCAGGTATTGAATTGGCTAATCAATTAGCAGATCTGAATTTGACAGACAGTGAAAAGTTAGACATTGCAACGGAAATTGAAGGACATCCAGACAATGTGGCACCGGCTTTATTTGGAAACCTCGTGATTTCCAGTTATATCAATCAAAAAGTTAATTATGTTGTTGCTGATTTTCCCAAAAGCTCTTTTATTGCTTTTATCCCTAATTATGAGTTAAAGACCAGTGACAGCCGTGATGTTTTACCAACAGATTTAACATATAAGGAAGCGGTGGCTGCTAGCTCAATTGCTAATGTTGCTATTGCCGGTCTTTTGACTGGTGATTTAAAGACAGCGGGTGAAGCTATTATGAATGACCGCTTTCATGAACGTTTTCGTCAATCCTTGGTAAGGGAATTTGCACAAATTAAGGAGATCGGTAAGCGAAACGGTGCTTATGCCAGCTACCTTTCTGGTGCAGGGCCGACGGTTATTGTCTTAACGGATCAAGATAAGGCTGATCAAATCAAGGCGGACATTGATGCTTTAGAGCTAAGTGGTAGTACTCATTTGCTTCGTATTGATGCTAAGGGTGTAAGGGTCGAGAAAAATTAA","5.00","-9.30","30960","MKITVPATSANIGPGFDSVGVALSKYLSIEVLEEAASWHISHDLGDIPSDEHNLLLVTALKVAPDLRPHRLRMVSDIPLARGLGSSSSVIVAGIELANQLADLNLTDSEKLDIATEIEGHPDNVAPALFGNLVISSYINQKVNYVVADFPKSSFIAFIPNYELKTSDSRDVLPTDLTYKEAVAASSIANVAIAGLLTGDLKTAGEAIMNDRFHERFRQSLVREFAQIKEIGKRNGAYASYLSGAGPTVIVLTDQDKADQIKADIDALELSGSTHLLRIDAKGVRVEKN","914587","For other 'thr' genes see SMu0063 (thrC); SMu1594 (thrA) and SMu1441 (thrS).","homoserine kinase","Cytoplasm","Several matches in gapped BLAST to homoserine kinase:residues 1-286 are 61% similar to the protein in S.pneumoniae (gi|2497513|).Residues 1-288 are 53% similar to the protein from Lactococcus lactis (gi|1730045|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1119 (1e-94).","

InterPro
IPR000870
Family

Homoserine kinase
PR00958	$\"[8-23]T$ $\"[84-99]T$ $\"[118-131]T$ $\"[156-173]T$ $\"[236-251]T$	HOMSERKINASE
PIRSF000676	$\"[1-288]T$	Homoser_kin
TIGR00191	$\"[1-288]T$	thrB

InterPro
IPR006203
Domain

GHMP kinase, ATP-binding region
PS00627	$\"[77-88]T$	GHMP_KINASES_ATP

InterPro
IPR006204
Domain

GHMP kinase
PF00288	$\"[70-131]T$	GHMP_kinases_N

InterPro
IPR013750
Domain

GHMP kinase, C-terminal
PF08544	$\"[191-270]T$	GHMP_kinases_C

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[1-101]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
PTHR20861	$\"[33-288]T$	PTHR20861
PTHR20861:SF1	$\"[33-288]T$	PTHR20861:SF1
SSF54211	$\"[1-147]T$	SSF54211
SSF55060	$\"[150-283]T$	SSF55060

","BeTs to 10 clades of COG0083COG name: Homoserine kinaseFunctional Class: EThe phylogenetic pattern of COG0083 is -m-kyqvcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** PR00958 (Homoserine kinase signature) with a combined E-value of 1.6e-50. PR00958A 8-23 PR00958B 84-99 PR00958C 118-131 PR00958D 156-173 PR00958E 236-251","Residues 39-133 are 32% similar to a (KINASE HOMOSERINE ATP-BINDING THREONINE) protein domain (PD124421) which is seen in O43056_SCHPO.Residues 120-252 are 31% similar to a (KINASE HOMOSERINE TRANSFERASE ATP-BINDING) protein domain (PD002374) which is seen in KHSE_BACSU.Residues 118-248 are 61% similar to a (KINASE ATP-BINDING THREONINE HOMOSERINE) protein domain (PD124414) which is seen in KHSE_STRPN.Residues 42-117 are 70% similar to a (KINASE ATP-BINDING THREONINE HOMOSERINE) protein domain (PD360117) which is seen in KHSE_STRPN.Residues 47-119 are 44% similar to a (KINASE TRANSFERASE ATP-BINDING) protein domain (PD008614) which is seen in KHSE_BACSU.Residues 3-40 are 76% similar to a (KINASE ATP-BINDING THREONINE HOMOSERINE) protein domain (PD039653) which is seen in KHSE_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 17:51:17 2002","Mon Jan 7 16:02:51 2002","Mon Oct 14 17:51:17 2002","Mon Jan 7 16:02:51 2002","Mon Jan 7 16:02:51 2002","Mon Jan 7 16:02:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0877 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 16:03:33 2002","Mon Jan 7 16:02:51 2002","pdb|1FWK|A Chain A, Crystal Structure Of Homoserine Kinase Comp... 97 2e-021","SMU.966","","Residues 68 to 256 (E-value = 3.3e-35) place SMu0877 in the GHMP_kinases family which is described as GHMP kinases putative ATP-binding protein (PF00288)","Mon Jan 7 16:02:51 2002","24379408","","","Madsen,S.M., Albrechtsen,B., Hansen,E.B. and Israelsen,H.Cloning and transcriptional analysis of two threonine biosyntheticgenes from Lactococcus lactis MG1614J. Bacteriol. 178 (13), 3689-3694 (1996)PubMed: 8682767Wizemann,T.M., Moskovitz,J., Pearce,B.J., Cundell,D.,Arvidson,C.G., So,M., Weissbach,H., Brot,N. and Masure,H.R.Peptide methionine sulfoxide reductase contributes to themaintenance of adhesins in three major pathogensProc. Natl. Acad. Sci. U.S.A. 93 (15), 7985-7990 (1996)PubMed: 8755589Parsot,C.Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydrataseEMBO J. 5 (11), 3013-3019 (1986)PubMed: 3098560","","Mon Jan 7 16:05:53 2002","1","","","SMU.966","379" "SMu0878","914758","916035","1278","ATGAATTATCAAGAAGCATTGACTTGGATACAGGATAGTTTAAAGTTTGGGATTAAACCGGGCTTGGAACGTATGACTTGGATGCTAGAAAAATTGGGCAATCCCCAACGGCATATTTGCGGCATCCATGTTGTCGGTACTAATGGTAAAGGATCCACTGTTAATGATTTACAAACTATTTTTAGTGAAGCAGGTTATCGGGTTGGGACTTTTATTTCACCTTATATTATTGATTTTAGAGAGCGAATCTCAATTAATGGTCGAATGATCAGTGAAAGGGATCTTGTTCATTTAGTTCAATTAGCCAAACCTGTGGTTGAACGTCTGCCTCTTGAGACTGATTTGGAAGCAGCGACAGAATTTGAAATTATCACGCTTTTAATGTTTCTTTATTTCGGGAAAGTGCATCCGGTTGATTTGGTTATTATTGAGGCAGGAATGGGCGGACTCTACGACTCAACCAATGTTTTTAAGGCGCAAGCCGTTATTTGTACCTCCATTGGACTGGACCATCAGGCTGTTTTGGGAGAGACTTATTCTGATATTGCTCAGCAAAAGGTCGGTGTTTTAAAAGAAGGAGTCCCTTTTATTTTTGCTGAAAAACGTCCTGATGTTAAAGCTGTTTTTTACCAAAAGGCCAAAGAAACTCAGAGCCCTATTTATGAGTTAGGGCAAACTTTTTATCTTGTAGATAAGGGTGAGAGGTTTGATTTTATTTGCGGTGATAAAAAGATTTCTGATATTAGATTGGCCATGCAAGGAAACCATCAAAGAGCTAATGCTGCTTTGGCTATTATGGCTACCCTTTTATTGCAAGAGCATTTTCCTAAGGTAACTGATACTGTTATTCAAAAAAGTCTGGTTCATAACTACTGGATAGGAAGGACAGAGTTTATCAAAGACAATCTTATGATTGATGGTGCTCATAATAATGAAAGTGTTGCCGCTTTAGTGGAACTTTTAAAAGAGCAGTATGCTGATAAAAAGATTCATATTCTTTTTGCAGCCATTAATACCAAACCAATTGACAGCATGTTAAAGCAATTAAATCAATTCACTGATTTGACTGTGACAACCTTTTCTTATCCTGATGCCCTTCCTTTGAAAGATTATCCACAGATTTACAAACAAGTCAGTAACTTTAAGCTTTGGCTCAAAAGATTAAGCAAGGCTCAAAGAGATGACTTTTATGTCATTACAGGATCGCTCTATTTTATTTCACAAGTCAGAAAAGTTCTTTTGAAAAATGAAGAAATAGGCTATAATAGATTGTATTAA","7.30","1.29","48408","MNYQEALTWIQDSLKFGIKPGLERMTWMLEKLGNPQRHICGIHVVGTNGKGSTVNDLQTIFSEAGYRVGTFISPYIIDFRERISINGRMISERDLVHLVQLAKPVVERLPLETDLEAATEFEIITLLMFLYFGKVHPVDLVIIEAGMGGLYDSTNVFKAQAVICTSIGLDHQAVLGETYSDIAQQKVGVLKEGVPFIFAEKRPDVKAVFYQKAKETQSPIYELGQTFYLVDKGERFDFICGDKKISDIRLAMQGNHQRANAALAIMATLLLQEHFPKVTDTVIQKSLVHNYWIGRTEFIKDNLMIDGAHNNESVAALVELLKEQYADKKIHILFAAINTKPIDSMLKQLNQFTDLTVTTFSYPDALPLKDYPQIYKQVSNFKLWLKRLSKAQRDDFYVITGSLYFISQVRKVLLKNEEIGYNRLY","916034","For other 'fol' genes see SMu0521 (folD); SMu0763 (folC);SMu0879 (folE); SMu0880 (folP); SMu0881 (folA) (folQ) and SMu0882 (folK). From Genbank: [gi:585155]This protein is involved in the conversion of folates to polyglutamate derivatives.It prefers 5,10-methylenetetrahydrofolate, rather than 10-formyltetrahydrofolate as folate substrate.","bifunctional protein: folylpolyglutamate synthase/dihydrofolate synthase","Cytoplasm","Several matches in gapped BLAST to folyl-polyglutamate synthetase :residues 1-418 are 57% similar to the protein in S.pyogenes (gi15675079).Residues 1-415 are 47% similar to the protein from S.suis (gi13345177). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1117 (1e-142).","

InterPro
IPR001645
Family

Folylpolyglutamate synthetase
TIGR01499	$\"[22-413]T$	folC

InterPro
IPR004101
Domain

Cytoplasmic peptidoglycan synthetases, C-terminal
PF02875	$\"[292-368]T$	Mur_ligase_C

InterPro
IPR013221
Domain

Mur ligase, middle region
PF08245	$\"[42-268]T$	Mur_ligase_M

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.10	$\"[2-289]T$	G3DSA:3.40.1190.10
G3DSA:3.90.190.20	$\"[294-424]T$	G3DSA:3.90.190.20
PTHR11136	$\"[26-352]T$	PTHR11136
SSF53244	$\"[294-413]T$	SSF53244
SSF53623	$\"[1-291]T$	SSF53623

","BeTs to 10 clades of COG0285COG name: Folylpolyglutamate synthaseFunctional Class: HThe phylogenetic pattern of COG0285 is ----Yqvcebrhuj---l--xNumber of proteins in this genome belonging to this COG is 2","***** IPB001645 (Folylpolyglutamate synthetase) with a combined E-value of 2e-46. IPB001645A 41-65 IPB001645B 68-88 IPB001645C 122-157 IPB001645D 162-195 IPB001645E 397-410","Residues 257-417 are 33% similar to a (SYNTHETASE PROTEOME DIHYDROFOLATE) protein domain (PD122331) which is seen in Q54614_STRPN.Residues 130-195 are 34% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS ENZYME) protein domain (PD212530) which is seen in Q9CN13_PASMU.Residues 213-413 are 35% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE PROTEOME) protein domain (PD122334) which is seen in Q9CGE0_LACLA.Residues 22-184 are 27% similar to a (FPGS ATP-BINDING SYNTHASE SYNTHETASE) protein domain (PD321109) which is seen in FOLC_YEAST.Residues 136-192 are 50% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE SYNTHETASE) protein domain (PD003937) which is seen in FOLC_BACSU.Residues 42-127 are 47% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE COMPLETE) protein domain (PD403087) which is seen in Q9CGE0_LACLA.Residues 42-92 are 47% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE PROTEOME) protein domain (PD413942) which is seen in O26070_HELPY.Residues 21-126 are 52% similar to a (SYNTHASE FOLYLPOLYGLUTAMATE SYNTHETASE) protein domain (PD164066) which is seen in Q9K8G9_BACHD.Residues 138-215 are 40% similar to a (SYNTHETASE PROTEOME FOLYL-POLYGLUTAMATE) protein domain (PD358647) which is seen in O13492_NEUCR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 10:34:43 2006","Wed Sep 13 10:34:43 2006","Wed Sep 13 10:34:43 2006","Mon Jan 7 16:08:46 2002","Mon Jan 7 16:08:46 2002","Mon Jan 7 16:08:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0878 is paralogously related (blast p-value < 1e-3) to SMu0763, a predicted folyl-polyglutamate synthetase.","Mon Jan 28 14:18:16 2002","Wed Sep 13 10:34:43 2006","pdb1FGS Folylpolyglutamate Synthetase From Lactobacillus C... 207 2e-054","SMU.967","","Residues 7 to 284 (E-value = 5.8e-09) place SMu0878 in the Mur_ligase family which is described as Mur ligase family, catalytic domain (PF01225)","Mon Jan 7 16:08:46 2002","24379409","","","Swedberg,G., Ringertz,S. and Skold,O.Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomaldihydropteroate synthaseAntimicrob. Agents Chemother. 42 (5), 1062-1067 (1998)PubMed: 9593127","","Mon Jan 7 16:11:09 2002","1","","","SMU.967","378" "SMu0879","916041","916619","579","ATGAATGAGAAAATAATGTCAGACCAAAAAAAGATTGAAGAAGCCGTTTATCAGTTGTTAGAAGCACTTGGTGAAGACCCTAATCGTGAGGGACTGTTGGATACGCCAAAGCGTGTTGCTAAGATGTATCAGGAAATGTTTGCAGGTCTTAATGAGGATCCTAAAGACCAGTTTACAGCTGTTTTTTCTGAAGAACATGAAGACGTTGTTTTAGTCAAGGATATCCCATTTTATTCTATGTGTGAGCATCATTTAGTCCCTTTTCACGGCTTAGCACATGTTGCCTATATTCCGAGTGACGGCTGCGTCACAGGACTTAGTAAATTAGCTCGTGCTGTTGAGGTGGTCAGCAAACGCCCGCAGCTGCAGGAGCGACTGACAGTTCAAATAGCTAATGCTCTTGAGGAAGCCTTAAAGCCTAAAGGTGTTCTTGTTATGATTGAAGCAGAGCACATGTGCATGACTATGAGAGGAATCAAAAAGCCTGGCAGCAAAACTGTAACCAGAGTTGTTAGAGGTATTTGCCAATCTGATAAAGAAACGCGTCAGGAAATTATAGCAATGATACATCATAACTAG","6.30","-3.26","21668","MNEKIMSDQKKIEEAVYQLLEALGEDPNREGLLDTPKRVAKMYQEMFAGLNEDPKDQFTAVFSEEHEDVVLVKDIPFYSMCEHHLVPFHGLAHVAYIPSDGCVTGLSKLARAVEVVSKRPQLQERLTVQIANALEEALKPKGVLVMIEAEHMCMTMRGIKKPGSKTVTRVVRGICQSDKETRQEIIAMIHHN","916618","For other 'fol' genes see SMu0521 (folD); SMu0763 (folC);SMu0878 (folC); SMu0880 (folP); SMu0881 (folA) (folQ) and SMu0882 (folK). ","GTP cyclohydrolase I","Cytoplasm","Several matches in gapped BLAST to GTP cyclohydrolase:residues 3-189 are 74% similar to the protein in S.pyogenes (gi14253168).Residues 8-189 are 67% similar to the protein from B.subtilis (gi16079335).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1116 (2e-82).","

InterPro
IPR001474
Family

GTP cyclohydrolase I
PD003330	$\"[32-192]T$	GTP_cyclohydroI
PF01227	$\"[68-173]T$	GTP_cyclohydroI
TIGR00063	$\"[12-191]T$	folE
PS00859	$\"[68-84]T$	GTP_CYCLOHYDROL_1_1
PS00860	$\"[117-127]T$	GTP_CYCLOHYDROL_1_2

noIPR
unintegrated

unintegrated
G3DSA:3.30.1130.10	$\"[57-191]T$	G3DSA:3.30.1130.10
PTHR11109	$\"[17-192]T$	PTHR11109
SSF55620	$\"[7-191]T$	SSF55620

","BeTs to 8 clades of COG0302COG name: GTP cyclohydrolase IFunctional Class: HThe phylogenetic pattern of COG0302 is ----yq-cebrhuJ------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001474 (GTP cyclohydrolase I) with a combined E-value of 2.6e-62. IPB001474A 23-40 IPB001474B 66-118 IPB001474C 138-158","Residues 10-189 are 74% similar to a (GTP CYCLOHYDROLASE I GTP-CH-I) protein domain (PD003330) which is seen in GCH1_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 15:06:39 2006","Wed Aug 30 15:06:39 2006","Wed Aug 30 15:06:39 2006","Mon Jan 7 16:21:22 2002","Mon Jan 7 16:21:22 2002","Mon Jan 7 16:21:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0879 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 16:21:55 2002","Wed Aug 30 15:06:39 2006","pdb1FB1A Chain A, Crystal Structure Of Human Gtp Cyclohydrola... 178 4e-046pdb1GTPA Chain A, Gtp Cyclohydrolase I >gi1943378pdb1GTPB... 125 3e-030pdb1A8RA Chain A, Gtp Cyclohydrolase I (H112s Mutant) In Comp... 122 3e-029","SMU.968","","Residues 68 to 173 (E-value = 1.2e-49) place SMu0879 in the GTP_cyclohydroI family which is described as GTP cyclohydrolase I (PF01227)","Mon Jan 7 16:21:22 2002","24379410","","","Swedberg,G., Ringertz,S. and Skold,O.Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomaldihydropteroate synthaseAntimicrob. Agents Chemother. 42 (5), 1062-1067 (1998)PubMed: 9593127Gollnick,P., Ishino,S., Kuroda,M.I., Henner,D.J. and Yanofsky,C.The mtr locus is a two-gene operon required for transcriptionattenuation in the trp operon of Bacillus subtilisProc. Natl. Acad. Sci. U.S.A. 87 (22), 8726-8730 (1990)PubMed: 2123343Babitzke,P., Gollnick,P. and Yanofsky,C.The mtrAB operon of Bacillus subtilis encodes GTP cyclohydrolase I(MtrA), an enzyme involved in folic acid biosynthesis, and MtrB, aregulator of tryptophan biosynthesisJ. Bacteriol. 174 (7), 2059-2064 (1992)PubMed: 1551827De Saizieu,A., Vankan,P. and van Loon,A.P.Enzymic characterization of Bacillus subtilis GTP cyclohydrolase I.Evidence for a chemical dephosphorylation of dihydroneopterintriphosphateBiochem. J. 306 (Pt 2), 371-377 (1995)PubMed: 7887891","","Mon Jan 7 16:27:24 2002","1","","","SMU.968","567" "SMu0880","916629","917429","801","ATGAAAATTGGTAAATATGATGTAGCTGGTAAAGCAGCTATTATGGGGATTCTCAATGTAACCCCAGATTCATTTTCAGATGGCGGACAATACGAAACAATCGATCAGGCTCTAAAACAGGTTGAAGCCATGTTGGCAGCAGGAGCGGCTATCATTGATATCGGCGGAGAATCCACACGTCCCGGCGCAGCATTTGTTTCTGCTGAGGATGAAATTAAACGGATTGTTCCAATTGTTGAAGCTATTAGCGAAAAGTTTAACTGCCTGATTAGCATTGATACCTATAAGACTGAGACTGCTCGAGTAGCCCTTGCTGCGGGAGCGCACATCTTAAATGATGTGTGGTCTGGTCTTTATGATGGGCAAATGTTTCAATTAGCAGCTGAAACTGGAGCGCCTATTATTTTGATGCACAATCAGTGTGAAGAAGTTTATGGCAATGTGACAGAAGATGTTTGCCAATTCTTGCTGGAACGTGCTGATTTAGCCCAAAAAACAGGAGTTAAAAAAGAAAATATTTGGCTTGATCCTGGTTTTGGTTTCGCTAAAAATGTCGAACAAAACATGGAACTTCTACGAGGCTTAGCGGAGGTGACTAAGCTTGGTTATCCTGTTTTATTTGGTATTTCTAGAAAACGTGTTGTTGATAGTTTGTTAGGCGGTCATACCAAGCCGCAAGAGCGAGACATGGCGACAGCGGCTCTTTCTGGCTATGCCATTAGTAAGGGCTGCAAAATTGTTAGAGTACATAACGTGGCTGCCAACAAAGACATTGTAAAGGTCAGCAGCCAGTTAGCATGA","5.30","-5.22","28605","MKIGKYDVAGKAAIMGILNVTPDSFSDGGQYETIDQALKQVEAMLAAGAAIIDIGGESTRPGAAFVSAEDEIKRIVPIVEAISEKFNCLISIDTYKTETARVALAAGAHILNDVWSGLYDGQMFQLAAETGAPIILMHNQCEEVYGNVTEDVCQFLLERADLAQKTGVKKENIWLDPGFGFAKNVEQNMELLRGLAEVTKLGYPVLFGISRKRVVDSLLGGHTKPQERDMATAALSGYAISKGCKIVRVHNVAANKDIVKVSSQLA","917428","For other 'fol' genes see SMu0521 (folD); SMu0763 (folC);SMu0878 (folC); SMu0879 (folE); SMu0881 (folA) (folQ) and SMu0882 (folK). ","dihydropteroate synthase","Cytoplasm","Several matches in gapped BLAST to dihydropteroate synthase :residues 1-265 are 69% similar to the protein in S.pyogenes (gi|2342547|).Residues 1-265 are 42% similar to the protein from Clostridium acetobutylicum (gi|15896179|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1115 (1e-98).","

InterPro
IPR000489
Domain

Dihydropteroate synthase, DHPS
G3DSA:3.20.20.20	$\"[7-265]T$	Dhdropt_synth
PF00809	$\"[17-219]T$	Pterin_bind
PS00792	$\"[14-29]T$	DHPS_1
PS00793	$\"[48-61]T$	DHPS_2
PS50972	$\"[12-260]T$	PTERIN_BINDING

InterPro
IPR006390
Domain

Dihydropteroate synthase
TIGR01496	$\"[13-265]T$	DHPS

InterPro
IPR011005
Domain

Dihydropteroate synthase-like
SSF51717	$\"[5-265]T$	DHP_synth_like

noIPR
unintegrated

unintegrated
PTHR20941	$\"[34-266]T$	PTHR20941
PTHR20941:SF1	$\"[34-266]T$	PTHR20941:SF1

","BeTs to 9 clades of COG0294COG name: Dihydropteroate synthaseFunctional Class: HThe phylogenetic pattern of COG0294 is amtkyqvCebRHuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB000489 (Dihydropteroate synthase) with a combined E-value of 3.7e-66. IPB000489A 14-29 IPB000489B 37-79 IPB000489C 166-183 IPB000489D 201-216 IPB000489E 243-252","Residues 15-263 are 69% similar to a (DIHYDROPTEROATE SYNTHASE FOLATE TRANSFERASE) protein domain (PD001976) which is seen in Q9R5Y1_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 17:55:39 2002","Mon Jan 7 16:33:16 2002","Mon Oct 14 17:55:39 2002","Mon Jan 7 16:33:16 2002","Mon Jan 7 16:33:16 2002","Mon Jan 7 16:33:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0880 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 16:33:54 2002","Mon Jan 7 16:33:16 2002","pdb|1AD1|A Chain A, Dihydropteroate Synthetase (Apo Form) From ... 212 4e-056pdb|1AJ0| Crystal Structure Of A Ternary Complex Of E. Coli D... 189 3e-049pdb|1EYE|A Chain A, 1.7 Angstrom Resolution Crystal Structure O... 165 6e-042","SMU.969","","Residues 17 to 219 (E-value = 3.4e-98) place SMu0880 in the Pterin_bind family which is described as Pterin binding enzyme (PF00809)","Mon Jan 7 16:33:16 2002","24379411","","","Swedberg,G., Ringertz,S. and Skold,O.Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomaldihydropteroate synthaseAntimicrob. Agents Chemother. 42 (5), 1062-1067 (1998)PubMed: 9593127Swedberg,G., Fermer,C. and Skold,O.Point mutations in the dihydropteroate synthase gene causingsulfonamide resistanceAdv. Exp. Med. Biol. 338, 555-558 (1993)PubMed: 8304179","","Mon Jan 7 16:34:57 2002","1","","","SMU.969","377" "SMu0881","917437","917799","363","ATGGATAAGATTATTTTAAAGGGTTGTCGTTTTTATGCTTATCATGGTGTTTTTTCTGAAGAAAAGACCTTGGGGCAGATTTTTACGGTTGACTTAGAACTCTCACTTGATTTAAAGGCAGCTTCAAAAACAGATAAATTGGAAGACACGGTGAATTACGGTCAAGTTTTTTCAGTACTTAAGAGTCGTATTGAAAACAGTCAATATACTCTGATCGAAAGATTGGCAGGGGTCATTTGTGAAGATATTTTTGAACAATTTTCACCAGTAAGGGCTATCAAAATTTGTATTACTAAAGAAAATCCGCCCATTGCTGGTCATTATGATAGGGTTGGTATTGAATTGAAACGAGAGCGCTCATGA","6.50","-0.67","13687","MDKIILKGCRFYAYHGVFSEEKTLGQIFTVDLELSLDLKAASKTDKLEDTVNYGQVFSVLKSRIENSQYTLIERLAGVICEDIFEQFSPVRAIKICITKENPPIAGHYDRVGIELKRERS","917798","For other 'fol' genes see SMu0521 (folD); SMu0763 (folC);SMu0878 (folC); SMu0879 (folE); SMu0880 (folP) and SMu0882 (folK). From Genbank:[gi:14195652]This protein catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.","dihydroneopterin aldolase","Cytoplasm","Several matches in gapped BLAST to dihydroneopterin aldolase :residues 1-119 are 64% similar to the protein in S.pyogenes (gi|15675082|) and are 44% similar to the protein from B.subtilis (gi|16077146|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1114 (8e-43).","

InterPro
IPR006156
Family

Dihydroneopterin aldolase family
TIGR00525	$\"[2-117]T$	folB

InterPro
IPR006157
Domain

Dihydroneopterin aldolase
PF02152	$\"[4-117]T$	FolB
TIGR00526	$\"[1-120]T$	folB_dom

noIPR
unintegrated

unintegrated
G3DSA:3.30.1130.10	$\"[2-120]T$	G3DSA:3.30.1130.10
PTHR20941	$\"[1-118]T$	PTHR20941
PTHR20941:SF3	$\"[1-118]T$	PTHR20941:SF3
SSF55620	$\"[2-119]T$	SSF55620

","BeTs to 5 clades of COG1539COG name: Dihydroneopterin aldolaseFunctional Class: HThe phylogenetic pattern of COG1539 is ----y--cEbrhuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB003098 (Dihydroneopterin aldolase) with a combined E-value of 8.1e-35. IPB003098A 2-46 IPB003098B 71-80 IPB003098C 90-117","Residues 11-119 are 63% similar to a (DIHYDRONEOPTERIN ALDOLASE DHNA LYASE) protein domain (PD004848) which is seen in FOLB_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 18:01:10 2002","Mon Jan 7 16:38:04 2002","Mon Oct 14 18:00:32 2002","Mon Jan 7 16:37:18 2002","Mon Jan 7 16:37:18 2002","Mon Jan 7 16:37:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0881 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 16:38:04 2002","Mon Jan 7 16:37:18 2002","pdb|1DHN| 1.65 Angstrom Resolution Structure Of 7,8-Dihydrone... 123 8e-030pdb|1DHN| 1.65 Angstrom Resolution Structure Of 7,8-Dihydrone... 211 3e-056","SMU.970","","Residues 4 to 117 (E-value = 2.9e-41) place SMu0881 in the FolB family which is described as Dihydroneopterin aldolase (PF02152)","Mon Jan 7 16:37:18 2002","24379412","","","Swedberg,G., Ringertz,S. and Skold,O.Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomaldihydropteroate synthaseAntimicrob. Agents Chemother. 42 (5), 1062-1067 (1998)PubMed: 9593127Hennig,M., D'Arcy,A., Hampele,I.C., Page,M.G., Oefner,C. andDale,G.E.Crystal structure and reaction mechanism of 7,8-dihydroneopterinaldolase from Staphylococcus aureusNat. Struct. Biol. 5 (5), 357-362 (1998)PubMed: 9586996Slock,J., Stahly,D.P., Han,C.Y., Six,E.W. and Crawford,I.P.An apparent Bacillus subtilis folic acid biosynthetic operoncontaining pab, an amphibolic trpG gene, a third gene required forsynthesis of para-aminobenzoic acid, and the dihydropteroatesynthase geneJ. Bacteriol. 172 (12), 7211-7226 (1990)PubMed: 2123867 Thomas MC, Ballantine SP, Bethell SS, Bains S, Kellam P, Delves CJ.Single amino acid substitutions disrupt tetramer formation in the dihydroneopterin aldolase enzyme of Pneumocystis carinii.Biochemistry. 1998 Aug 18;37(33):11629-36.PMID: 9709001 ","","Mon Oct 14 18:01:10 2002","1","","","SMU.970","813" "SMu0882","917796","918275","480","ATGACACTTGTTTATTTAAGTCTAGGCAGTAACATAGGAGAACGGCAGACTTATTTGCAGAGAGCTTTAGAGGAACTGGCTCATCTCTCTCATATTACTTTACAGGCAGTGTCCCCTATCTATGAAACAGCGGCCTGGGGAAAGACAGATCAAGCTGATTTTTTAAATATTGTTTGTCAACTCGAAACTGACTTATCACCATACGATTTACTAGAGGCTTGTCAAAAAATTGAAAAACATTTAAATCGTGTCCGTCATGAACATTGGGGTCCCAGAACAATTGATATTGATATCTTATTTTATGGAAATACTATTATTAAAGAGGATAACCTCAAAATCCCCCATCCCTATTTGCAGAATCGTGCTTTTGTTTTGGTTCCTCTTAATGATATTGCCAGTGAATTAGTTCATCCGGTTTTAAAGGAAACGGTAGCTGTTTTGCTGGAAAAAGTGGACAAATCAGGAGTTAAAATCTGGTAG","5.90","-4.41","18166","MTLVYLSLGSNIGERQTYLQRALEELAHLSHITLQAVSPIYETAAWGKTDQADFLNIVCQLETDLSPYDLLEACQKIEKHLNRVRHEHWGPRTIDIDILFYGNTIIKEDNLKIPHPYLQNRAFVLVPLNDIASELVHPVLKETVAVLLEKVDKSGVKIW","918274","For other 'fol' genes see SMu0521 (folD); SMu0763 (folC);SMu0878 (folC); SMu0879 (folE); SMu0880 (folP) and SMu0881 (folA),(folQ). "," 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase","Cytoplasm","Several matches in gapped BLAST to 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase:residues 1-159 are 52% similar to the protein in S.pyogenes (gi|15675083|).Residues 3-159 are 42% similar to the protein from B.subtilis (gi|16077147|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1113 (2e-49).","

InterPro
IPR000550
Domain

7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK
PF01288	$\"[5-132]T$	HPPK
TIGR01498	$\"[4-133]T$	folK
PS00794	$\"[88-99]T$	HPPK

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.560	$\"[2-158]T$	G3DSA:3.30.70.560
PTHR20941	$\"[40-145]T$	PTHR20941
PTHR20941:SF2	$\"[40-145]T$	PTHR20941:SF2
SSF55083	$\"[1-159]T$	SSF55083

","BeTs to 9 clades of COG0801COG name: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinaseFunctional Class: HThe phylogenetic pattern of COG0801 is ----yqvcebrhuj----in-Number of proteins in this genome belonging to this COG is 1","***** IPB000550 (7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase) with a combined E-value of 7.5e-44. IPB000550A 4-18 IPB000550B 51-74 IPB000550C 78-101 IPB000550D 111-128","Residues 1-115 are 60% similar to a (PYROPHOSPHOKINASE FOLATE) protein domain (PD003866) which is seen in HPPK_STRPY.Residues 4-128 are 34% similar to a (PYROPHOSPHOKINASE BIOSYN) protein domain (PD339029) which is seen in HPPK_HELPY.Residues 4-159 are 34% similar to a (PROTEOME COMPLETE PA0583) protein domain (PD339218) which is seen in Q9I5V4_PSEAE.Residues 1-99 are 41% similar to a (PYROPHOSPHOKINASE BIOSYN) protein domain (PD282817) which is seen in HPPK_MYCLE.Residues 4-116 are 39% similar to a (78- BIFUNCTIONAL SYNTHESIS 6-) protein domain (PD295797) which is seen in FOKP_CHLPN.Residues 3-132 are 28% similar to a (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE) protein domain (PD399687) which is seen in Q9EZA4_ZYMMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 18:01:36 2002","Mon Jan 7 16:44:43 2002","Mon Oct 14 18:01:36 2002","Mon Jan 7 16:44:43 2002","Mon Jan 7 16:44:43 2002","Mon Jan 7 16:44:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0882 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 16:47:12 2002","Mon Jan 7 16:44:43 2002","pdb|1CBK|A Chain A, 7,8-Dihydro-6-Hydroxymethylpterin-Pyrophosp... 126 2e-030pdb|1DY3|A Chain A, Ternary Complex Of 7,8-Dihydro-6-Hydroxymet... 114 6e-027","SMU.971","","Residues 5 to 132 (E-value = 2.4e-68) place SMu0882 in the HPPK family which is described as 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) (PF01288)","Mon Jan 7 16:44:43 2002","24379413","","","Slock,J., Stahly,D.P., Han,C.Y., Six,E.W. and Crawford,I.P.An apparent Bacillus subtilis folic acid biosynthetic operoncontaining pab, an amphibolic trpG gene, a third gene required forsynthesis of para-aminobenzoic acid, and the dihydropteroatesynthase geneJ. Bacteriol. 172 (12), 7211-7226 (1990)PubMed: 2123867Swedberg,G., Ringertz,S. and Skold,O.Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomaldihydropteroate synthaseAntimicrob. Agents Chemother. 42 (5), 1062-1067 (1998)PubMed: 9593127","","Mon Jan 7 16:49:18 2002","1","","","SMU.971","812" "SMu0883","918410","919330","921","ATGATGTTAAATGAAATGAACAAAAGTTTAGAAGGCGTTGATATCCGTATTAATGAACCCCTAAAAAAATATACCTATACAAAAGTGGGCGGTCCAGCTGATTTTTTAGCCTTTCCACGTAATCGTTATGAACTCGCTCGCATTGTTAAATTTGCTAATCAAAATAACCTACCTTGGATGGTTTTAGGAAATGCCAGTAATTTGATTGTGCGTGATGGTGGGATTCGTGGCTTTGTCATCATGTTTGACAAACTTAATGCTGTGACTGTTGATGGTTATGTAATTGAAGCAGAAGCAGGTTCTAATCTAATTGAAACAACTAAAGTTGCTCAATATCATAGCTTGACTGGCTTTGAATTTGCTTGTGGCATTCCGGGAAGTATTGGTGGTGCTGTTTTTATGAATGCTGGTGCTTACGGTGGTGAAATCTCTCATATTTTGATCTCAGCTCAGGTTTTAACTAGAGATGGTGAGATTAAAACAATTGAAGCGCGAGATATGCGCTTTGGTTATCGTCATTCTGTTTTACAAGATAATCAGGAAGTTGTTGTTTCAGCCAAGTTTTCTTTAAAACCAGGGGATTATACTATTATCAGTCAGGAAATGCAGCGTTTAAATCATTTACGAGCACTTAAACAACCTTTAGAGCATCCTTCTTGTGGTTCAGTCTTCAAGCGTCCCTTAGGACATTTTGCAGGTCAGTTGATTATGGAAGCTCAATTGATGGGACATCGCATTGGTGGTGTTGAAGTCAGCACAAAACATGCCGGTTTTATGGTCAATGTCGCCAACGGTTCAGCTAAAAATTACGAAGATCTAATTGCTGATGTTATTCATAGAGTTAAAGAAAATTCTGGTGTTACTCTTGAACCAGAGGTTCGAATTATTGGTGAAAAAGAAGTACAAATGGAGGACTCATAG","6.80","-0.91","33758","MMLNEMNKSLEGVDIRINEPLKKYTYTKVGGPADFLAFPRNRYELARIVKFANQNNLPWMVLGNASNLIVRDGGIRGFVIMFDKLNAVTVDGYVIEAEAGSNLIETTKVAQYHSLTGFEFACGIPGSIGGAVFMNAGAYGGEISHILISAQVLTRDGEIKTIEARDMRFGYRHSVLQDNQEVVVSAKFSLKPGDYTIISQEMQRLNHLRALKQPLEHPSCGSVFKRPLGHFAGQLIMEAQLMGHRIGGVEVSTKHAGFMVNVANGSAKNYEDLIADVIHRVKENSGVTLEPEVRIIGEKEVQMEDS","919329","For other 'mur' genes see SMu0549 (murF); SMu0653 (murN); SMu0654 (murM); SMu1529 (murE); SMu1566 (murI); SMu0498 (murD);SMu0499 (murG); SMu1577 (murC); SMu1304 (murC);SMu1386 (murA) and SMu1429 (murZ). From Genbank:[gi:140583] This protein is involved in cell wall formation.","UDP-N-acetylenolpyruvoylglucosamine reductase","Cytoplasm","Several matches in gapped BLAST to UDP-N-acetylenolpyruvoylglucosamine reductase:residues 6-298are 78% similar to the protein in S.pyogenes gi|15675084|.Residues 5-298 are 73% similar to the protein from S.pneumoniae gi|15901244|The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1112 (1e-136).","

InterPro
IPR003170
Family

UDP-N-acetylenolpyruvoylglucosamine reductase
PTHR21071	$\"[1-306]T$	MurB
TIGR00179	$\"[21-297]T$	murB

InterPro
IPR006094
Domain

FAD linked oxidase, N-terminal
PF01565	$\"[33-163]T$	FAD_binding_4

InterPro
IPR011601
Domain

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal
PF02873	$\"[195-297]T$	MurB_C

noIPR
unintegrated

unintegrated
G3DSA:3.30.43.10	$\"[1-86]T$	G3DSA:3.30.43.10
G3DSA:3.30.465.10	$\"[87-213]T$	G3DSA:3.30.465.10
G3DSA:3.90.78.10	$\"[214-297]T$	G3DSA:3.90.78.10
SSF56176	$\"[20-209]T$	SSF56176
SSF56194	$\"[193-301]T$	SSF56194

","BeTs to 11 clades of COG0812COG name: UDP-N-acetylmuramate dehydrogenaseFunctional Class: MThe phylogenetic pattern of COG0812 is -----Qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003170 (UDP-N-acetylenolpyruvoylglucosamine reductase) with a combined E-value of 1.3e-65. IPB003170A 61-70 IPB003170B 95-145 IPB003170C 157-177 IPB003170D 218-227 IPB003170E 233-287","Residues 18-90 are 61% similar to a (CELL FAD NADP ALL) protein domain (PD017080) which is seen in MURB_LACLA.Residues 19-80 are 43% similar to a (CELL REDUCTASE) protein domain (PD111572) which is seen in MURB_BACSU.Residues 95-296 are 72% similar to a (CELL REDUCTASE) protein domain (PD004983) which is seen in MURB_LACLA.Residues 14-80 are 38% similar to a (UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE CELL WALL) protein domain (PD209855) which is seen in Q9RNM8_ZYMMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 18:02:32 2002","Mon Jan 7 16:54:12 2002","Mon Oct 14 18:02:32 2002","Mon Jan 7 16:54:12 2002","Mon Jan 7 16:54:12 2002","Mon Jan 7 16:54:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0883 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 16:54:34 2002","Mon Jan 7 16:54:12 2002","pdb|1MBB| Oxidoreductase >gi|1827629|pdb|1MBT| Oxidoreductase 90 3e-019pdb|2MBR| Murb Wild Type, Complex With Enolpyruvyl-Udp-N-Ace... 88 2e-018pdb|1UXY| Murb Mutant With Ser 229 Replaced By Ala, Complex ... 87 4e-018","SMU.972","","Residues 33 to 181 (E-value = 5.1e-31) place SMu0883 in the FAD_binding_4 family which is described as FAD binding domain (PF01565)Residues 195 to 297 (E-value = 6.3e-34) place SMu0883 in the MurB_C family which is described as UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain (PF02873)","Mon Jan 7 16:54:12 2002","24379414","","","Beall,B. and Lutkenhaus,J.Nucleotide sequence and insertional inactivation of a Bacillussubtilis gene that affects cell division, sporulation, andtemperature sensitivityJ. Bacteriol. 171 (12), 6821-6834 (1989)PubMed: 2556375Miyao,A., Yoshimura,A., Sato,T., Yamamoto,T., Theeragool,G. andKobayashi,Y.Sequence of the Bacillus subtilis homolog of the Escherichia colicell-division gene murGGene 118 (1), 147-148 (1992)PubMed: 1387377Harry,E.J. and Wake,R.G.Cloning and expression of a Bacillus subtilis division initiationgene for which a homolog has not been identified in anotherorganismJ. Bacteriol. 171 (12), 6835-6839 (1989)PubMed: 2556376Rowland,S.L., Errington,J. and Wake,R.G.The Bacillus subtilis cell-division 135-137 degrees region contains an essential orf with significant similarity to murB and a dispensable sbp geneGene 164 (1), 113-116 (1995)PubMed: 7590298","","Thu Mar 21 09:02:25 2002","1","","","SMU.972","376" "SMu0884","919334","920488","1155","TTGACTAAGCCAATCATTGCATTTAAAAATGTGTCAAAGGTTTTTGAAGACAATGGTACTGTTGTTTTAAAAAATATTAACTTTGAATTAGAAGAAGGGAAGTTTTACACGCTTCTTGGAGCGTCCGGTTCAGGGAAATCAACCATTCTAAATCTAATCGCGGGTTTACTGGAAGCAAGCAGCGGTGGTATTTTTCTTGATGGAAAACGAATCAATGATATCCCTATCAATAAACGTGATGTACACACGGTCTTTCAGTCTTATGCTCTCTTTCCTCATATGACAGTTTTTGAAAATGTTGCCTTTCCGCTAAAATTACGAAAAGTAGCTAAGAAAGAAATTGAAAAACGTGTCACGGAAGCCTTAAACATGGTGCGTTTGGCTGGTTTTGAAAAGCGTTCGATTGGAAAATTATCAGGCGGTCAGAGACAGCGTGTTGCCATTGCTCGTGCCATTATCAATCAGCCTAAGGTTGTTTTACTGGATGAGCCTCTGTCAGCTTTGGATTTGAAATTGCGAACAGAAATGCAGTATGAATTGCGAGATCTGCAGCAGCGTTTAGGGATTACATTTGTCTTTGTAACGCACGATCAAGAAGAAGCGCTAGCCATGTCTGATTGGATTTTTGTCATGAATGATGGGGAAATTGTTCAATCAGGAACACCTGTTGATATTTATGATGAACCAATCAACCATTTTGTTGCTACTTTTATTGGAGAATCTAATATTCTGCCAGCTGTTATGATTGAGGATTACTTGGTTGAGTTCAATGGTAAGCGTTTCGAAGCTGTTGATGGTGGTATGCGGCCTAATGAAGCTGTTGAAGTGGTTATTCGACCGGAAGATTTGCAGATTACGTTGCCAGAAGAAGGCAAGCTTCAGGTCAAAGTTGAAACACAGCTTTTTCGTGGTGTTCATTATGAAATTATCGCTCATGATGAACTTGGCAATGAATGGATGATTCATTCAACGCATAAAGCTATTGAAGGTGAGATTATCGGACTTGACTTTACACCTGAAGATATTCATATCATGCGGCTCAATGAAACTGAAGCAGAATTTGATGCCCGTATTGAAGAATATGTGGAAACAGAAGAACATGAAGAAGGTCTAATAAATGCCATAGAGGAGGAGCGTCATGAAGAGGAAAGTTAA","4.60","-25.29","43503","MTKPIIAFKNVSKVFEDNGTVVLKNINFELEEGKFYTLLGASGSGKSTILNLIAGLLEASSGGIFLDGKRINDIPINKRDVHTVFQSYALFPHMTVFENVAFPLKLRKVAKKEIEKRVTEALNMVRLAGFEKRSIGKLSGGQRQRVAIARAIINQPKVVLLDEPLSALDLKLRTEMQYELRDLQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQSGTPVDIYDEPINHFVATFIGESNILPAVMIEDYLVEFNGKRFEAVDGGMRPNEAVEVVIRPEDLQITLPEEGKLQVKVETQLFRGVHYEIIAHDELGNEWMIHSTHKAIEGEIIGLDFTPEDIHIMRLNETEAEFDARIEEYVETEEHEEGLINAIEEERHEEES","920487","For other components see SMu0886 (MSD1); SMu0885 (MSD2) and SMu0887 (SBP1). For other 'pot' genes see SMu0885 (potB); SMu0886 (potC) and SMu0887 (potD).For other 'msm' genes see SMu0799 (msmR); SMu0801 (msmE); SMu0802 (msmF); SMu0803 (msmG); SMu0805 (msmK); SMu1079 (msmK); SMu1428 (msmK) and SMu0594 (msmK).From Genbank:[gi:130688]This protein is part of the binding-protein-dependent transport system for spermidine/putrescine.It is probably responsible for energy coupling to the transport system. ","ABC transporter ATP-binding protein - spermidine/putrescine transport","Cytoplasm, Membrane","Matches in gapped BLAST to ATP-binding protein :residues 10-322are 36% similar to the previously published enzyme in S.mutans(gi|153741|). Several matches in gapped BLAST to spermidine/putrescine ABC transporter, ATP-binding protein:residues 1-375 are 85% similar to the protein in S.pneumoniae (gi|15901243|) and are 74% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673145|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1111 (0.0).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[138-180]T$	Q8E554_STRA3_Q8E554;
PF00005	$\"[33-214]T$	ABC_tran
PS50893	$\"[6-238]T$	ABC_TRANSPORTER_2
PS00211	$\"[138-152]T$	ABC_TRANSPORTER_1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[32-215]T$	AAA

InterPro
IPR013611
Domain

Transport-associated OB
PF08402	$\"[276-345]T$	TOBE_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-241]T$	no description
PTHR19222	$\"[6-294]T$	ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF43	$\"[6-294]T$	SPERMIDINE/PUTRESCINE ABC TRANSPORTER

","BeTs to 9 clades of COG1130COG name: ABC-type sugar transport system, ATPase componentFunctional Class: GThe phylogenetic pattern of COG1130 is -mtK--VCEBRh--GP-L---Number of proteins in this genome belonging to this COG is 4","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 7.9e-39. IPB001140A 22-68 IPB001140B 135-173 IPB001140C 191-220","Residues 4-269 are 23% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 181-218 are 84% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9CGD4_LACLA.Residues 6-224 are 25% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD313900) which is seen in Q9WZT4_THEMA.Residues 118-201 are 36% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in Q9CCF9_MYCLE.Residues 310-375 are 63% similar to a (ATP-BINDING PROTEOME COMPLETE) protein domain (PD396201) which is seen in Q9CGD4_LACLA.Residues 30-214 are 27% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 121-220 are 33% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9Y979_AERPE.Residues 23-170 are 20% similar to a (TRANSMEMBRANE FROM YEAST SIMILAR) protein domain (PD244363) which is seen in Q9VC16_DROME.Residues 224-346 are 35% similar to a (ATP-BINDING TRANSPORT) protein domain (PD407534) which is seen in Q9PR37_UREPA.Residues 183-226 are 63% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472) which is seen in O57942_PYRHO.Residues 20-223 are 24% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 183-222 are 67% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9CP06_PASMU.Residues 78-112 are 74% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496) which is seen in Q9V293_PYRAB.Residues 89-233 are 23% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 23-74 are 78% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CGD4_LACLA.Residues 224-335 are 38% similar to a (ATP-BINDING PROTEOME COMPLETE TRANSPORT) protein domain (PD198794) which is seen in O51587_BORBU.Residues 137-180 are 77% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9HY19_PSEAE.Residues 225-309 are 81% similar to a (ATP-BINDING PROTEOME COMPLETE TRANSPORT) protein domain (PD021015) which is seen in Q9CGD4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 18:03:37 2002","Tue Jan 8 08:04:38 2002","Mon Oct 14 18:03:37 2002","Tue Jan 8 08:02:41 2002","Tue Jan 8 08:02:41 2002","Tue Jan 8 08:02:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0884 is paralogously related (blast p-value < 1e-3) to SMu1428, SMu0805, SMu0971, SMu1920, SMu1003, SMu0594, SMu1950, SMu0731, SMu1380, SMu0517, SMu1762, SMu1079, SMu0418, SMu1288, SMu1210, SMu0849, SMu0218, SMu0235, SMu1757, SMu1949, SMu0786, SMu0390, SMu1068, SMu0335, SMu0916, SMu1246, SMu1231, SMu1001, SMu1518, SMu1751, SMu0234, SMu1316, SMu0950, SMu0907, SMu0216, SMu1517, SMu1410, SMu0596, SMu1649, SMu1036, SMu0824, SMu0944, SMu0976, SMu1545, SMu0836, SMu1023, SMu1811, SMu1710, SMu1037, SMu0986, SMu0258, SMu0752, SMu0374, SMu0476, SMu0164, SMu1064, SMu1065, SMu0475, SMu0024, SMu0987, SMu0224, SMu1050, SMu0825, SMu0837, SMu0666, SMu1093, SMu1724, SMu1306, SMu1959, SMu0823, SMu0729, SMu1686, and SMu1202 all with ATP-binding capabilities.","Mon Jan 28 14:24:14 2002","Tue Jan 8 08:02:41 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 247 2e-066pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 121 1e-028","SMU.973","","Residues 33 to 214 (E-value = 2.7e-69) place SMu0884 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jan 8 08:02:41 2002","24379415","","A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 1537846Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene ofStreptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248","Furuchi,T., Kashiwagi,K., Kobayashi,H. and Igarashi,K.Characteristics of the gene for a spermidine and putrescinetransport system that maps at 15 min on the Escherichia colichromosomeThe Journal of biological chemistry. 266 (31), 20928-20933 (1991)PubMed: 1939142","Wed Mar 27 11:42:09 2002","Tue Jan 8 08:10:30 2002","1","","","SMU.973","126" "SMu0885","920472","921266","795","ATGAAGAGGAAAGTTAATTTCTTTTTCCTGCCTTATCTTCTTTGGATAGGTCTTTTTGTGTTAGCGCCGGTAGCACTTATTCTTTACAAATCTTTTTTTGATATTGAGGGACATGTCACTTTAAGCAATTATCAAACTTTTTTTGCCAACTGGACTTATTTGAAAATGAGTCTTAATTCTATTTTATATGCTGCTATTATTACGCTGGTGACACTTCTTATTTCTTATCCAACGGCACTTATCTTGACAAATCTTAAGCACAAACAATTGTGGTTAATGTTAGTTATCTTGCCCACTTGGATTAACCTTTTACTTAAAGCTTATGCTTTTATGGGGATTTTTGGTTATCATGGCGGTGTTAATAGTTTTTTACAGTTTATGGGATTGGCACCTAAGCAAATTCTTTTTACTGATTTTTCTTTTATTTTCGTGGCTTCTTATATTGAAATCCCCTTTATGATTTTGCCTATTTTTAATGCTCTTGATGATATTGATTCCAATCTTATCAATGCTAGTCGTGATTTAGGGGCAACTGATTGGCAGACCTTCACCAAGGTCATTTTCCCCTTGTCTTTAAATGGTGTTAGAAGTGGTGTTCAATCTGTTTTCATCCCTAGTCTCAGTCTTTTTATGCTGACACGTCTAATTGGTGGTAATCGCGTCATTACTTTAGGGACTGCTATTGAACAGCACTTTCTGACAACACAAAATTGGGGAATGGGTTCAACTATTGGTGTCATTTTGATTGTTACCATGCTTGTTATTATGTGGGTAACTAAGGAGAGAAAGAAATGA","10.50","7.94","30018","MKRKVNFFFLPYLLWIGLFVLAPVALILYKSFFDIEGHVTLSNYQTFFANWTYLKMSLNSILYAAIITLVTLLISYPTALILTNLKHKQLWLMLVILPTWINLLLKAYAFMGIFGYHGGVNSFLQFMGLAPKQILFTDFSFIFVASYIEIPFMILPIFNALDDIDSNLINASRDLGATDWQTFTKVIFPLSLNGVRSGVQSVFIPSLSLFMLTRLIGGNRVITLGTAIEQHFLTTQNWGMGSTIGVILIVTMLVIMWVTKERKK","921265","For other components see SMu0884 (NBD1); SMu0886 (MSD1) and SMu0887 (SBP1).For other 'pot' genes see SMu0886 (potC); SMu0887 (potD) and SMu0884 (potA).From Genbank: [gi:1172563]This protein is required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. ","spermidine / putrescine ABC transporter (permease protein)","Membrane, Cytoplasm","Several matches in gapped BLAST to spermidine/putrescine ABCtransporter (permease protein):residues 1-264 are 81% similar tothe protein in S.pyogenes (gi|15675086|).Residues 2-264 are 74% similar to the protein from S.pneumoniae (gi|15903288|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1110 (1e-120).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[57-264]T$	BPD_transp_1
PS50928	$\"[57-259]T$	ABC_TM1

","BeTs to 6 clades of COG1176COG name: ABC-type spermidine/putrescine transport system, permease component IFunctional Class: EThe phylogenetic pattern of COG1176 is a-----v-E--h--gpol---Number of proteins in this genome belonging to this COG is 1","***** IPB000515 (Binding-protein-dependent transport systems inner membrane component) with a combined E-value of 5.3e-06. IPB000515 170-189","Residues 63-148 are 39% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD002244) which is seen in Q9HY18_PSEAE.Residues 8-52 are 48% similar to a (PROTEOME COMPLETE SPERMIDINE/PUTRESCINE) protein domain (PD380310) which is seen in Q9CGD3_LACLA.Residues 53-148 are 71% similar to a (PROTEOME COMPLETE PERMEASE TRANSPORT) protein domain (PD034713) which is seen in Q9CGD3_LACLA.Residues 10-155 are 28% similar to a (PROTEOME PERMEASE COMPLETE ABC) protein domain (PD272208) which is seen in Q9PPH7_CAMJE.Residues 151-256 are 79% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in Q9CGD3_LACLA.Residues 150-261 are 28% similar to a (PROTEOME COMPLETE POTB) protein domain (PD168308) which is seen in O83659_TREPA.Residues 147-253 are 32% similar to a (TRANSPORT SPERMIDINE/PUTRESCINE SYSTEM) protein domain (PD027983) which is seen in POTB_MYCPN.Residues 150-240 are 31% similar to a (PROTEOME COMPLETE OF ABC) protein domain (PD392674) which is seen in Q9I5T3_PSEAE.Residues 13-131 are 25% similar to a (MEMBRANE INNER YDCU ABC) protein domain (PD079735) which is seen in YDCU_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 18:04:19 2002","Tue Jan 8 08:24:17 2002","Mon Oct 14 18:04:19 2002","Tue Jan 8 08:23:43 2002","Tue Jan 8 08:23:43 2002","Tue Jan 8 08:23:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0885 is paralogously related (blast p-value < 1e-3) to SMu1426 and SMu1427,both predicted maltose/maltodextrin ABC transporter; SMu0886, a predicted spermidine/putrescine ABC transporter (permease protein); SMu1002, SMu0802,and SMu0803, both predicted multiple sugar-binding transport system permease protein; SMu1923,a predicted betaine/carnitine/choline ABC transporter (membrane permease OpuCD); SMu0970,a predicted glycinebetaine-binding protein; SMu1039,a predicted phosphate ABC transporter.","Mon Jan 28 14:32:23 2002","","No significant hits to the NCBI PDB database.","SMU.974","","No significant hits to the Pfam 11.0 database","Tue Jan 8 08:23:43 2002","24379416","","","Furuchi,T., Kashiwagi,K., Kobayashi,H. and Igarashi,K.Characteristics of the gene for a spermidine and putrescinetransport system that maps at 15 min on the Escherichia colichromosomeJ. Biol. Chem. 266 (31), 20928-20933 (1991)PubMed: 1939142","","Tue Jan 8 08:32:39 2002","1","","","SMU.974","375" "SMu0886","921263","922039","777","ATGAAGAAAATAGGGCATTTATATTTAACGCTTGTATTTTTAATTCTTTATATTCCTATCTTTTATTTGATTTTTTATTCCTTTAATCAAGCAGGAGATATGAATCGTTTTACTGGTTTGACTTTAGAACATTATACAACTATGTTTAACGATCAGCGGTTAATGTTGATTCTTGTCGAAACCTTTCTGCTAGCATTTCTAAGCTCCTTATTGGCAACAGTTATTGGGACTTTTGGAGCGATTTTAATTTACCAAGTAAAAAAGAAGAATCAAAATACAATTTTGTCCATTAATAATGTCCTTATGGTAGCACCTGATGTGATGATTGGGGCCTCTTTCTTGATTCTCTTTACCTTTATTGGCTTTAAATTGGGCATGTTTTCCGTTCTTCTTAGTCACATCGCCTTTTCCATTCCTATTGTCGTTCTAATGGTTCTTCCCAGATTAAAAGAAATGAATGATGATATGGTTCATGCGGCTTATGACTTAGGAGCCAGCTACTTTCAAATGTTAAAAGAAGTGATGCTGCCTTATTTAACACCTAGCATTATTGCTGGGTATTTTATGGCTTTTACTTATTCTTTAGATGATTTTGCAGTAACTTTTTTTGTTACCGGAAATGGCTTTTCGACTCTTTCAGTTGAAATTTATTCCCGTGCTCGTAAGGGAATTTCTTTAGAAATCAATGCCTTGTCAACGGTTGTTTTCTTATTTAGCATTCTGCTTGTCATTGGTTATTATTTTATTTCGCAGGATAGGGAGGAAAAATATGCATAA","7.00","0.00","29299","MKKIGHLYLTLVFLILYIPIFYLIFYSFNQAGDMNRFTGLTLEHYTTMFNDQRLMLILVETFLLAFLSSLLATVIGTFGAILIYQVKKKNQNTILSINNVLMVAPDVMIGASFLILFTFIGFKLGMFSVLLSHIAFSIPIVVLMVLPRLKEMNDDMVHAAYDLGASYFQMLKEVMLPYLTPSIIAGYFMAFTYSLDDFAVTFFVTGNGFSTLSVEIYSRARKGISLEINALSTVVFLFSILLVIGYYFISQDREEKYA","922038","For other components see SMu0884 (NBD1); SMu0885 (MSD2) and SMu0887 (SBP1).For other 'pot' genes see SMu0885 (potB); SMu0887 (potD) and SMu0884 (potA).From Genbank:[gi:130690]This protein is required for the activity of the bacterialperiplasmic transport system of putrescine and spermidine.","spermidine/putrescine ABC transporter, permease","Membrane, Cytoplasm","Several matches in gapped BLAST to spermidine/putrescine ABCtransporter permease protein:residues 1-258 are 70% similar tothe protein in S.pyogenes (gi15675087) and residues 1-256 are 69% similar to the protein from S.pneumoniae (gi15903287)The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1109 (4e-98).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[58-256]T$	BPD_transp_1
PS50928	$\"[58-246]T$	ABC_TM1

","BeTs to 6 clades of COG1177COG name: ABC-type spermidine/putrescine transport system, permease component IIFunctional Class: EThe phylogenetic pattern of COG1177 is a-----v-E--h--gpol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 140-235 are 32% similar to a (ABC TRANSPORTER THIAMINE COMPLETE) protein domain (PD151368) which is seen in O86752_STRCO.Residues 139-244 are 76% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in Q9CGD2_LACLA.Residues 125-249 are 25% similar to a (TRANSPORT SPERMIDINE/PUTRESCINE SYSTEM) protein domain (PD027983) which is seen in Q9PR36_UREPA.Residues 74-136 are 65% similar to a (PERMEASE PROTEOME TRANSPORT COMPLETE) protein domain (PD095474) which is seen in Q9CGD2_LACLA.Residues 118-243 are 30% similar to a (ATTB) protein domain (PD057495) which is seen in O32731_AGRTU.Residues 4-60 are 40% similar to a (PROTEOME COMPLETE SPERMIDINE/PUTRESCINE) protein domain (PD387094) which is seen in Q9CGD2_LACLA.Residues 74-134 are 38% similar to a (TRANSPORT SPERMIDINE/PUTRESCINE PERMEASE) protein domain (PD079685) which is seen in O51585_BORBU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 10:18:56 2006","Wed Sep 13 10:18:56 2006","Wed Sep 13 10:18:56 2006","Tue Jan 8 08:33:42 2002","","Tue Jan 8 08:33:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0886 is paralogously related (blast p-value < 1e-3) to SMu0885,a predicted spermidine / putrescine ABC transporter (permease protein); SMu0802,a predicted multiple sugar-binding transport system permease protein; SMu1923, a predicted betaine/carnitine/choline ABC transporter (membrane permease OpuCD); SMu0970,a predicted glycinebetaine-binding protein; SMu1426 and SMu1427,both predicted maltose/maltodextrin ABC transporter;SMu1039, a predicted phosphate ABC transporter. ","Mon Jan 28 14:38:12 2002","","No significant hits to the NCBI PDB database.","SMU.975","","Residues 58 to 256 (E-value = 9.8e-10) place SMu0886 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Tue Jan 8 08:33:42 2002","24379417","","","Furuchi,T., Kashiwagi,K., Kobayashi,H. and Igarashi,K.Characteristics of the gene for a spermidine and putrescinetransport system that maps at 15 min on the Escherichia colichromosomeThe Journal of biological chemistry. 266 (31), 20928-20933 (1991)PubMed: 1939142","","Tue Jan 8 08:37:14 2002","1","","","SMU.975","374" "SMu0887","922032","923105","1074","ATGCATAAACTTTATTCCTTTATAGGAAGTATTTTCCTTATTATCCTGCTTTTGATTGGCTTAAACTTCTATATGAATCAACAGATAGAAGGGAAAGGAGCTTCTGATAAGCTGGTTATTTATAACTGGGGGGATTATATTGATCCCGAACTTCTGACAAAATTTACCAAAGAAACAGGCATTCAGGTTCAATATGAAACTTTTGATTCCAATGAAGCTATGTATACCAAAATCAAGCAAGGTGGAACAACTTATGATATTGCTGTTCCTAGCGATTACATGATTAGCAAAATGAAGGCAGAGCATCTTTTGGTTAAGCTTGATAAATCAAAAATTAAGGGTTTAACTAATCTTGATCAGCAATTTCTTGGTAAGAGTTTTGATAAAGACAACACCTATTCTATTCCTTATTTTTGGGGAACAGTAGGTATCGTTTACAATAGCAAAATGCTAACTAAAGTACCTCAGCATTGGAATGACCTTTGGAATAAAGCATATACCAATAAGATTATGCTTGTTGATGGTGCACGTGAGGTACTTGGTTTTAGTCTCAATAGTCTTACTTATAGCCTCAATACTAAAAATAGGGCAGAGTTGGAGCGAGCTGAAAGGAAGCTCAATCAGTTGACACCCAATATTAAAGCTATCGTTGGTGATGAGATGAAGGGTTATCTCATTCGAGGAGATGCTGCTCTTGGTGTGACATTTTCAGGAGAAGCTAGAGAAATGCTGGATACCAATAAAGATCTTCGTTACCTCGTTCCTGGCGAAGGTTCCAATCTTTGGTTTGATAATCTAGTTATTCCTAAAACAGTCAAACACAAAAAGTCTGCCTATACTTTCATTAATTTTATGCTAAAGCCAGAAAACGCGGCTCAAAATGCTGAATATATTGGCTACGCAACGCCAAATGCTAAGGCGAAAGATTTACTACCGGCTGATATAAAAAATAATAAATCTTTTTATCCAAGTAAGGAAACAATAGGTCATTTAGAAGTCTATGATAATCTTGGCAAGAAGTGGCTGGGTATTTATAATGATCTCTATTTGCAATTTAAAATGTATCGTAAATAA","9.90","8.22","40899","MHKLYSFIGSIFLIILLLIGLNFYMNQQIEGKGASDKLVIYNWGDYIDPELLTKFTKETGIQVQYETFDSNEAMYTKIKQGGTTYDIAVPSDYMISKMKAEHLLVKLDKSKIKGLTNLDQQFLGKSFDKDNTYSIPYFWGTVGIVYNSKMLTKVPQHWNDLWNKAYTNKIMLVDGAREVLGFSLNSLTYSLNTKNRAELERAERKLNQLTPNIKAIVGDEMKGYLIRGDAALGVTFSGEAREMLDTNKDLRYLVPGEGSNLWFDNLVIPKTVKHKKSAYTFINFMLKPENAAQNAEYIGYATPNAKAKDLLPADIKNNKSFYPSKETIGHLEVYDNLGKKWLGIYNDLYLQFKMYRK","923104","For other components see SMu0884 (NBD1); SMu0886 (MSD1) and SMu0885 (MSD2). For other 'pot' genes see SMu0885 (potB); SMu0886 (potC) and SMu0884 (potA).From Genbank:[gi:130691]This protein is required for the activity of the bacterialperiplasmic transport system of putrescine and spermidine.","spermidine/putrescine ABC transporter, spermidine/putrescine-binding protein","Cytoplasm, Extracellular","Several matches in gapped BLAST to spermidine/putrescine ABC transporter (periplasmic transport protein):residues 1-357 are 67% similar to the protein in S.pyogenes (gi15675088). Residues 35-264 are 69% similar to the protein from S.pneumoniae (gi15901240). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1108 (1e-146).","

InterPro
IPR001188
Family

Bacterial periplasmic spermidine/putrescine-binding protein
PR00909	$\"[41-57]T$ $\"[57-78]T$ $\"[84-98]T$ $\"[100-113]T$ $\"[131-147]T$ $\"[156-170]T$ $\"[174-193]T$ $\"[211-230]T$ $\"[255-274]T$ $\"[300-326]T$	SPERMDNBNDNG

InterPro
IPR006059
Family

Bacterial extracellular solute-binding protein, family 1
PF01547	$\"[12-292]T$	SBP_bac_1

InterPro
IPR011587
Domain

Prokaryotic extracellular metal-binding protein
PD008688	$\"[229-289]T$	MBP_prokaryotic

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[33-170]T$ $\"[243-322]T$	G3DSA:3.40.190.10
SSF53850	$\"[35-353]T$	SSF53850

","BeTs to 6 clades of COG0687COG name: Spermidine/putrescine-binding periplasmic proteinFunctional Class: EThe phylogenetic pattern of COG0687 is ------vcE--H--gpol---Number of proteins in this genome belonging to this COG is 1","***** PR00909 (Bacterial periplasmic spermidine/putrescine-binding protein signature) with a combined E-value of 4.8e-59. PR00909A 41-57 PR00909B 57-78 PR00909C 84-98 PR00909D 100-113 PR00909E 131-147 PR00909F 156-170 PR00909G 174-193 PR00909H 211-230 PR00909I 255-274 PR00909J 300-326","Residues 37-161 are 28% similar to a (PROTEOME PERIPLASMIC COMPLETE) protein domain (PD321171) which is seen in Q9KU25_VIBCH.Residues 32-156 are 63% similar to a (COMPLETE PROTEOME SUGAR TRANSPORT) protein domain (PD001485) which is seen in Q9CGD1_LACLA.Residues 158-314 are 53% similar to a (COMPLETE PROTEOME PERIPLASMIC ABC) protein domain (PD038035) which is seen in Q9CGD1_LACLA.Residues 37-160 are 28% similar to a (LIPOPROTEIN POLYAMINE-BINDING) protein domain (PD354915) which is seen in O86741_STRCO.Residues 128-316 are 25% similar to a (PROTEOME COMPLETE PERIPLASMIC) protein domain (PD350893) which is seen in Q9PPI0_CAMJE.Residues 47-111 are 53% similar to a (PROTEOME COMPLETE PERIPLASMIC TRANSPORTER) protein domain (PD178139) which is seen in Q9KS37_VIBCH.Residues 315-354 are 62% similar to a (PROTEOME BINDING COMPLETE SUBSTRATE) protein domain (PD375088) which is seen in Q9CGD1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 17:28:46 2006","Tue Sep 12 17:28:46 2006","Tue Sep 12 17:28:46 2006","Tue Jan 8 08:43:20 2002","Tue Jan 8 08:43:20 2002","Tue Jan 8 08:43:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0887 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 08:44:23 2002","Tue Sep 12 17:28:46 2006","pdb1POT SpermidinePUTRESCINE-Binding Protein Complexed Wit... 247 1e-066pdb1POY2 Chain 2, SpermidinePUTRESCINE-Binding Protein Comple... 247 1e-066pdb1A99A Chain A, Putrescine Receptor (Potf) From E. Coli >gi... 157 2e-039","SMU.976","","Residues 12 to 292 (E-value = 6.1e-13) place SMu0887 in the SBP_bac_1 family which is described as Bacterial extracellular solute-binding protein (PF01547)","Tue Jan 8 08:43:20 2002","24379418","","","Furuchi,T., Kashiwagi,K., Kobayashi,H. and Igarashi,K.Characteristics of the gene for a spermidine and putrescinetransport system that maps at 15 min on the Escherichia colichromosomeJ. Biol. Chem. 266 (31), 20928-20933 (1991)PubMed: 1939142Matsuo,Y. and Nishikawa,K.Prediction of the structural similarity betweenspermidine/putrescine-binding protein and maltose-binding proteinFEBS Lett. 345 (1), 23-26 (1994)PubMed: 8194593Sugiyama,S., Vassylyev,D.G., Matsushima,M., Kashiwagi,K.,Igarashi,K. and Morikawa,K.Crystal structure of PotD, the primary receptor of the polyaminetransport system in Escherichia coliJ. Biol. Chem. 271 (16), 9519-9525 (1996)PubMed: 8621624Sugiyama,S., Matsuo,Y., Maenaka,K., Vassylyev,D.G., Matsushima,M.,Kashiwagi,K., Igarashi,K. and Morikawa,K.The 1.8-A X-ray structure of the Escherichia coli PotD proteincomplexed with spermidine and the mechanism of polyamine bindingProtein Sci. 5 (10), 1984-1990 (1996)PubMed: 8897598","","Tue Jan 8 08:46:23 2002","1","","","SMU.976","373" "SMu0888","923185","923319","135","ATGAAAATTGAAAAAGTGTTTAATAACAATGTCGTTCAGATACTTGGTATCAACAACGAAGAGATTATTGTTATGGGGAAGGGGCTAGGTTTTCAAAAAAAGCCCGGTGATGAGGTCAATCAAGATTTAATCTAA","4.90","-1.02","4910","MKIEKVFNNNVVQILGINNEEIIVMGKGLGFQKKPGDEVNQDLI$","923318","For other 'lic' genes see SMu0889 (licT); SMu1453 (licA); SMu1454 (licR) and SMu1455 (licB).From Genbank:[gi:729940]This protein mediates positive regulation of the glucanase operon (LICST) by functioning as an antiterminator factor of transcription. It prevents termination at terminator LIC-T .","transcription antiterminator LicT (fragment)","Cytoplasm","Several matches in gapped BLAST to transcription antiterminator: residues 1-41 are 53% similar to the protein in B.subtilis (gi16080959).Residues 1-44 are 43% similar to the protein from Listeria monocytogenes (gi16804810). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0789 (2e-05).","

InterPro
IPR004341
Domain

CAT RNA-binding region
G3DSA:2.30.24.10	$\"[1-44]T$	no description
PF03123	$\"[1-44]T$	CAT_RBD

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","Tue Nov 20 13:01:39 2007","Tue Nov 20 13:01:39 2007","Tue Nov 20 13:01:39 2007","Tue Nov 20 13:01:39 2007","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","Tue Nov 20 13:01:39 2007","","Tue Nov 20 13:01:39 2007","Tue Nov 20 13:01:39 2007","Tue Nov 20 13:01:39 2007","Tue Jan 8 08:47:49 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0888 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 08:48:12 2002","","No significant hits to the NCBI PDB database.","SMU.977","","Residues 1 to 44 (E-value = 1.8e-10) place SMu0888 in the CAT_RBD family which is described as CAT RNA binding domain (PF03123)","Tue Jan 8 08:47:49 2002","24379419",""," Cote CK, Honeyman AL.Transcriptional analysis of the bglP gene from Streptococcus mutans.BMC Microbiol. 2006 Apr 21;6:37.PMID: 16630357","el Hassouni,M., Henrissat,B., Chippaux,M. and Barras,F.Nucleotide sequences of the arb genes, which control beta-glucoside utilization in Erwinia chrysanthemi: comparison with the Escherichia coli bgl operon and evidence for a newbeta-glycohydrolase family including enzymes from eubacteria,archeabacteria, and humansJ. Bacteriol. 174 (3), 765-777 (1992)PubMed: 1732212Schnetz,K., Stulke,J., Gertz,S., Kruger,S., Krieg,M., Hecker,M. and Rak,B.LicT, a Bacillus subtilis transcriptional antiterminator protein of the BglG familyJ. Bacteriol. 178 (7), 1971-1979 (1996)PubMed: 8606172Murphy,N., McConnell,D.J. and Cantwell,B.A.The DNA sequence of the gene and genetic control sites for theexcreted B. subtilis enzyme beta-glucanaseNucleic Acids Res. 12 (13), 5355-5367 (1984)PubMed: 6087283","Tue Nov 20 13:01:39 2007","Tue Nov 20 13:01:39 2007","1","","","SMU.977","" "SMu0890","924428","926362","1935","ATGGCTAAAGATTATACCGAATTAGCGCAAGATATTGTCTCCCATGTTGGTGGCAAAGATAATATCGTTAAGCTTGTTCACTGTGTTACTCGCTTGCGTTTTACTCTCAAAGATGAAAGCAAGGCTGATGATGATTACCTCAAACAACGTGAAGGTATTGTGACTGTTGTCAAAGCAGGTGGACAATATCAAGTTGTTATTGGAAATCATGTTCCTGATGTCTATGATACTGTCCTAAAAGTAAGCGGCATTACTGGAGAAGGCGGTATTGATGTGGATGAAGGAGATATTCCAAAGGGAAATCTTTTTGATCGTTTCATTGCTCTCGTTTCAGGACTGTTCCAACCAATGCTGGGAGCTCTTTCAGCAGCAGGTATGATTAAAGGTCTAGTTGCTATTTTAGCAGCAGTAGGGGTTTCGAAAACAGATGGTGCTTATGTTGTTCTCAATGCAGCAGGTGATGGCTTTTTCCAATTCTTGCCTTTGATTCTTGCACTTACAGCAGCTAAGCGTTTTAAAATGGAGCAATTTACAGCCTTAGCTATTGGTTTTGCTCTGGTTTATCCCAATATTGCAGCTAGTTTTACAGTAAAACACCCACTTTATACTTTGTTCCAAGGAACCTTAATTGAATCTCCTATTTATTCAACATTCTTTGGAATACCAATTATTTTCCCAGCCTCTAGTTATTTGCAGACTGTCTTACCAATCGTTGTAGCGATTTGGGCTGGTTCCAAAATAGAAACTTTCTTTAAAAAGATTATTCCAGATGTGGTTAAGGTATTCGTTGTTCCCTTCTTTACAATTTTAATAACTGTTCCCCTTTCCTTCTTAGTTATTGGTCCTGTGATGAGTTGGGCATCTGATCTTGTAGGTGCTATCTTTACAGGTATTTATGGCTTTAATCCAGTTATTTACGGCATCGTTCTTGGTGCTATGTGGCAAGTGCTTGTTATGTTTGGACTTCACTGGGGACTTGTTCCGCTTGCTATTTTGGAACTACAAAAAGGACCTGGTGTCATTCTTGTAGCGACTATCGCCATTTGTTTTGCTCAAGCTGGATCACTGCTTAATATTATGATGCGTACCAAAGAAAATAAGGTTAGACAATTATCTATTCCAGCCTTTATTTCTGCCCTTTTCGGTGTAACAGAACCAGCTATTTATGGTATTACACTTCCAATGCGTGTACCGTTTATCATGACCTGCGTTTCTGGAGCTATTTCAGGTGCTTATCTTGCTCTTTTTAATGTAAAAATGCAGGTTATGGGAGGTATGGGGCTCTTTGCTATTCCTTCTTTCATTGATCCTAAAAATTCAATGATCTTAATTCATTTCTTAATCGCTATTGCTATGAACTTTGTTCTTGGTTTTGTTTTAACACAATTTATTAAAATTCCTTATCTTTATGGTGAACCAACAAGTACAGATAGTGATGTTGATGATAAGGAAGAACCTGTAAAAGAACTCAAAGAAATTAAACAAGAAATCATTTCTAGCCCACTCATTGGTAAAGTAGTTAAATTGGAAAATGTTCCTGATGAAGTTTTTGCTTCAGGTGCTATGGGTAAAGGAATTGCTATTGATCCAGATGATGGTATTGTTGTTGCACCGACTAAAGGTGAAGTAACGCTTGTCTTTCCAACTAAACATGCTGTTGGCTTAAGGACTGAAAATGGTGCAGAAATTCTCATTCATATTGGTATGGATACTGTCTCTCTTGCAGGTAAAGGTTTCAAATCTTTTGTTAAAGTTGGTGATCATGTTGAAGCTGGCCAAACTTTACTTGAATTTGATGTTAATGCTATAAAGGCTGCTGGACTTCCGGTCATTACACCAGTTATTGTCACTAATTCAGATCAATTTGAAGATGTCTTGACGACTCAAGAACGGACTGTAGAAGCAGGAGATTACCTTCTTACAGCTGTTAAATAA","5.40","-8.94","69270","MAKDYTELAQDIVSHVGGKDNIVKLVHCVTRLRFTLKDESKADDDYLKQREGIVTVVKAGGQYQVVIGNHVPDVYDTVLKVSGITGEGGIDVDEGDIPKGNLFDRFIALVSGLFQPMLGALSAAGMIKGLVAILAAVGVSKTDGAYVVLNAAGDGFFQFLPLILALTAAKRFKMEQFTALAIGFALVYPNIAASFTVKHPLYTLFQGTLIESPIYSTFFGIPIIFPASSYLQTVLPIVVAIWAGSKIETFFKKIIPDVVKVFVVPFFTILITVPLSFLVIGPVMSWASDLVGAIFTGIYGFNPVIYGIVLGAMWQVLVMFGLHWGLVPLAILELQKGPGVILVATIAICFAQAGSLLNIMMRTKENKVRQLSIPAFISALFGVTEPAIYGITLPMRVPFIMTCVSGAISGAYLALFNVKMQVMGGMGLFAIPSFIDPKNSMILIHFLIAIAMNFVLGFVLTQFIKIPYLYGEPTSTDSDVDDKEEPVKELKEIKQEIISSPLIGKVVKLENVPDEVFASGAMGKGIAIDPDDGIVVAPTKGEVTLVFPTKHAVGLRTENGAEILIHIGMDTVSLAGKGFKSFVKVGDHVEAGQTLLEFDVNAIKAAGLPVITPVIVTNSDQFEDVLTTQERTVEAGDYLLTAVK","926361","For other 'bgl' genes see SMu0700 (bglB); SMu0891 (bglB); SMu0892 (bglB); SMu0893 (bglC); SMu0895 (bglA); SMu1007 (bglA); SMu1285 (bglC); SMu1454 (bglG) and SMu1456 (bglA).From Genbank:[gi:131487]This protein is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system. The IICD domains contain the sugar binding site and the transmembrane channel;the IIA domain contains the primary phosphorylation site (the donor is phospho-HPr);IIA transfers its phosphoryl group to the IIB domain which finally transfers it to sugar . ","beta-glucoside-specific EII permease","Membrane, Cytoplasm","Matches in gapped BLAST to beta-glucoside-specific EII permease:residues 1-644 are 93% similar to the previously published protein in S.mutans (gi|9622919|).Residues 5-643 are 47% similar to the enzyme from Clostridium acetobutylicum (gi|15894686|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0790 (2e-95).","

InterPro
IPR001127
Domain

Phosphotransferase system, sugar-specific permease EIIA 1 domain
PD002243	$\"[494-634]T$	PTS_EIIA
PF00358	$\"[493-625]T$	PTS_EIIA_1
TIGR00830	$\"[498-618]T$	PTBA
PS00371	$\"[560-572]?$	PTS_EIIA_TYPE_1_HIS
PS51093	$\"[514-618]T$	PTS_EIIA_TYPE_1

InterPro
IPR001996
Domain

Phosphotransferase system, EIIB
PD001476	$\"[36-74]T$	Ptrans_EIIB
PF00367	$\"[9-43]T$	PTS_EIIB
PS01035	$\"[21-38]T$	PTS_EIIB_TYPE_1_CYS
PS51098	$\"[6-88]T$	PTS_EIIB_TYPE_1

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[111-406]T$	PTS_EIIC

InterPro
IPR011055
Domain

Duplicated hybrid motif
SSF51261	$\"[489-643]T$	Dup_hybrid_motif

InterPro
IPR011297
Family

Phosphotransferase system, beta-glucoside-specific IIABC component
TIGR01995	$\"[5-643]T$	PTS-II-ABC-beta

InterPro
IPR013013
Domain

Phosphotransferase system, EIIC component, type 1
PS51103	$\"[108-476]T$	PTS_EIIC_TYPE_1

noIPR
unintegrated

unintegrated
G3DSA:2.70.70.10	$\"[484-640]T$	G3DSA:2.70.70.10
G3DSA:3.30.1360.60	$\"[2-95]T$	G3DSA:3.30.1360.60
SSF55604	$\"[8-86]T$	SSF55604

","No hits to the COGs database.","***** IPB001127 (Sugar-specific permease, EIIA 1 domain) with a combined E-value of 1.8e-48. IPB001127A 498-532 IPB001127B 537-579***** IPB001996 (PTS (phosphotransferase system) EIIB domain) with a combined E-value of 1.8e-30. IPB001996A 9-43 IPB001996B 59-71","Residues 62-288 are 85% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE II ENZYME IIBC) protein domain (PD003077) which is seen in Q9KJ80_STRMU.Residues 9-43 are 94% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIABC) protein domain (PD001476) which is seen in Q9KJ80_STRMU.Residues 394-512 are 31% similar to a (PROTEOME IIABC BETA-GLUCOSIDE-SPECIFIC) protein domain (PD395601) which is seen in Q9CFK9_LACLA.Residues 300-463 are 28% similar to a (COMPONENT PHOSPHOTRANSFERASE IIABC SUGAR) protein domain (PD337461) which is seen in O68468_CORAM.Residues 298-393 are 98% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIBC IIABC) protein domain (PD024747) which is seen in Q9KJ80_STRMU.Residues 398-463 are identical to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIBC) protein domain (PD229066) which is seen in Q9KJ80_STRMU.Residues 464-513 are identical to a (BETA-GLUCOSIDE-SPECIFIC PERMEASE EII) protein domain (PD380694) which is seen in Q9KJ80_STRMU.Residues 514-618 are 99% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE TRANSPORT PTS IIABC) protein domain (PD002243) which is seen in Q9KJ80_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 26 16:41:58 2002","Tue Jan 8 09:29:16 2002","Mon Oct 14 18:07:33 2002","Tue Jan 8 09:27:23 2002","Tue Jan 8 09:27:23 2002","Tue Jan 8 09:27:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0890 is paralogously related (blast p-value < 1e-3) to SMu1677, a predicted PTS system,sucrose specific IIABC component; SMu1852, a predicted phosphotransferase system, trehalose-specific IIBC component (EIIBC-tre); SMu1858, a predicted PTS system, enzyme II, A component; and SMu0061, a predicted acyltransferase.","Mon Jan 28 14:45:20 2002","Tue Jan 8 09:27:23 2002","pdb|1AX3| Solution Nmr Structure Of B. Subtilis Iiaglc, 16 S... 143 8e-035pdb|1GGR|A Chain A, Complex Of Enzyme Iiaglc And The Histidine-... 116 1e-026pdb|1F3G| Phosphocarrier Iiiglcfast >gi|2914331|pdb|1F3Z| ... 116 1e-026","SMU.980","","Residues 9 to 43 (E-value = 2.1e-16) place SMu0890 in the PTS_EIIB family which is described as phosphotransferase system, EIIB (PF00367)Residues 111 to 406 (E-value = 3.2e-28) place SMu0890 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)Residues 514 to 618 (E-value = 2.8e-62) place SMu0890 in the PTS_EIIA_1 family which is described as phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PF00358)","Tue Jan 8 09:27:23 2002","24379420",""," Cote CK, Honeyman AL.Transcriptional analysis of the bglP gene from Streptococcus mutans.BMC Microbiol. 2006 Apr 21;6:37. PMID: 16630357 Cote CK, Honeyman AL.The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549Cote,C.K., Cvitkovitch,D., Bleiweis,A.S. and Honeyman,A.L.A novel beta-glucoside-specific PTS locus from streptococcus mutans that is not inhibited by glucoseMicrobiology 146 (Pt 7), 1555-1563 (2000)PubMed: 10878120Sato Y, Poy F, Jacobson GR, Kuramitsu HKCharacterization and sequence analysis of the scrA gene encoding enzyme IIScr of the Streptococcus mutans phosphoenolpyruvate - dependent sucrose phosphotransferase system.J Bacteriol 1989 Jan;171(1):263-71PubMed: 2536656PMID: 2536656Sato Y, Yamamoto Y, Kizaki H, Kuramitsu HKIsolation, characterization and sequence analysis of the scrK gene encoding fructokinase of Streptococcus mutans.J Gen Microbiol 1993 May;139 ( Pt 5):921-7PubMed: 8336109PMID: 8336109 ","el Hassouni,M., Henrissat,B., Chippaux,M. and Barras,F.Nucleotide sequences of the arb genes, which control beta-glucoside utilization in Erwinia chrysanthemi: comparison with the Escherichia coli bgl operon and evidence for a newbeta-glycohydrolase family including enzymes from eubacteria,archeabacteria, and humansJ. Bacteriol. 174 (3), 765-777 (1992)PubMed: 1732212Brown,G.D. and Thomson,J.A.Isolation and characterisation of an aryl-beta-D-glucoside uptakeand utilisation system (abg) from the gram-positive ruminalClostridium species C. longisporumMol. Gen. Genet. 257 (2), 213-218 (1998)PubMed: 9491080","Sat Oct 26 16:41:58 2002","Tue Jan 8 10:08:51 2002","1","","","SMU.980","" "SMu0891","926535","927422","888","ATGCTGTTCTGGAGCACTGTCGATCTAGGTCTTACTTTTATGGCAACCAGTTCTACATTGGCTTTTGATTCAAGTAATCGTATCGATGATGTTAAAATTGTTATTAAAGGTTATGAATTCGGCCCTGCTGTACCTAAACTTGTTGTTAAATTGAATCAAAAAATTTCCAAGGTGTCTACTAAGGATCTCAAAGTAGAAACAGCAGGAGTAAAACGTCAGATTAAGAAAGTTTATCTATCTGATAAAAATAGTCAAAAATCTACAAAGAAAGAAGGCGATTACCTAACAATTCAAATGCCTGTCACATATAATGTTGATGACAGCAGTAAAAACGCATCCCCTTTTGTTTATAATACAGATGTTTTCCAAAATCAGTGGGTTAAGACTTACCCTGTTTCCATTAAAGGTTTAACAGTATCTTATAAAGGCAAATCAACCAACAATCTGACCTCTAAAAGTGATGCCATTAATAAGCGGGTATCGCCAGATTCAGAAGTCTTTACTAATCGAGGAAGTTTTTCAGGCAATTATACCAATCCTTTGACGAAGAAAAACGAAAAAGTTGACTTGCAATATGCGGCTTATGAACCTAAAAAATTACAATCAGGTAATAAAAACCCATTGATTATTTGGTTGCATGGACAAGGAGAGGGTGGAACAGATCCTGATATTACTCTTCTTGGGAATAAAGTAACCGCTTTGATCAAAGAGGATATTCAAAATCACTTTAAGTCTGGTAATCAAAAAGGTACTTATGTTTTGACTGTTCAAGCTCCAACTTATTGGATGGATGAAGGTGATGGTAGCAATGGTCAGGGAGCAGGAACTTCCCGTTATACAGAGGTGCTTATGGATGCTATCAAAAAATATGTGGCCAAAATAACCTAA","10.20","11.48","32673","MLFWSTVDLGLTFMATSSTLAFDSSNRIDDVKIVIKGYEFGPAVPKLVVKLNQKISKVSTKDLKVETAGVKRQIKKVYLSDKNSQKSTKKEGDYLTIQMPVTYNVDDSSKNASPFVYNTDVFQNQWVKTYPVSIKGLTVSYKGKSTNNLTSKSDAINKRVSPDSEVFTNRGSFSGNYTNPLTKKNEKVDLQYAAYEPKKLQSGNKNPLIIWLHGQGEGGTDPDITLLGNKVTALIKEDIQNHFKSGNQKGTYVLTVQAPTYWMDEGDGSNGQGAGTSRYTEVLMDAIKKYVAKIT","927421","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0892 (bglB); SMu0893 (bglC); SMu0895 (bglA); SMu1007 (bglA); SMu1285 (bglC); SMu1454 (bglG) and SMu1456 (bglA).SMu0891 and SMu0892 either represent one gene with a frameshift or a pseudogene.","beta-glucosidase, BglB protein","Periplasm, Extracellular","Matches in gapped BLAST to beta-glucoside:residues 1-292 are 98% similar to the previously published protein in S.mutans (gi|9622920|).Residues 13-230 are 23% similar to a hypothetical protein in Thermotoga maritima (gi|15642808|). SMu0891 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF53474	$\"[151-262]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-275 are 98% similar to a (BGLB) protein domain (PD316577) which is seen in Q9KJ79_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 26 16:42:35 2002","Mon Oct 14 18:09:23 2002","Mon Oct 14 18:09:23 2002","Tue Jan 8 10:13:34 2002","","Tue Jan 8 10:13:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0891 is paralogously related (blast p-value < 1e-3) to SMu0700, a predicted BglB-like protein.","Mon Jan 28 14:48:33 2002","","No significant hits to the NCBI PDB database.","SMU.981","","No significant hits to the Pfam 11.0 database","Tue Jan 8 10:13:34 2002","24379421","","Cote CK, Honeyman AL. The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549 Cote,C.K., Cvitkovitch,D., Bleiweis,A.S. and Honeyman,A.L. A novel beta-glucoside-specific PTS locus from streptococcus mutansthat is not inhibited by glucose Microbiology 146 (Pt 7), 1555-1563 (2000) PubMed: 10878120","el Hassouni,M., Henrissat,B., Chippaux,M. and Barras,F. Nucleotide sequences of the arb genes, which control beta-glucosideutilization in Erwinia chrysanthemi: comparison with the Escherichiacoli bgl operon and evidence for a new beta-glycohydrolase family including enzymes from eubacteria, archeabacteria, and humans J. Bacteriol. 174 (3), 765-777 (1992) PubMed: 1732212 Brown,G.D. and Thomson,J.A. Isolation and characterisation of an aryl-beta-D-glucoside uptake and utilisation system (abg) from the gram-positive ruminal Clostridium species C. longisporum Mol. Gen. Genet. 257 (2), 213-218 (1998) PubMed: 9491080 ","Sat Oct 26 16:42:35 2002","Tue Jan 8 10:17:58 2002","1","","","SMU.981","" "SMu0892","927460","928017","558","ATGACGATTAATATGGCTTTACATTATCCTAATTATTTCGCTGCTCTAGTTCCTCAAGCAACAGCCTATTCTTATTATCAATATGAAAGAAATAATGATGGCACCTATAAAATGATTGAGGATAAGAACAGTATTTCGGGCAAATCAAGTATTAGGACAAATAAAATATGGTTTGATAGTCAAAAAGTTAAAACCTTAAAGAATATTCCAATTTGGTTTATCCATTCGGCAGCAGATAAGGTTGTTAATCCAAAGACTTATTCATTGCCAATTTACAAATCTCTTCTTGATAGTGGTGCTAAGAATAAATGGTTTTCTTATTATGATAATGTTCAAGGAAAAGACCTGAAAGATACCACATATAATGGTCATTGGTCTTGGGTTTATTTCTTCAATAATCAAGTATCAAGTGTTCAAGATGTTAAAACCATTAAGAAATCTTCAAAATTGTCAGGATTTAAACCTAGCAATAAAAGTAAGGGAGGAGCGGCAACTGCCAAAGAAGGCAAGAAAAGTTATAACAATGTTTTTGATTGGTTGAACGATCAAAAAAAGTAA","10.50","14.70","21294","MTINMALHYPNYFAALVPQATAYSYYQYERNNDGTYKMIEDKNSISGKSSIRTNKIWFDSQKVKTLKNIPIWFIHSAADKVVNPKTYSLPIYKSLLDSGAKNKWFSYYDNVQGKDLKDTTYNGHWSWVYFFNNQVSSVQDVKTIKKSSKLSGFKPSNKSKGGAATAKEGKKSYNNVFDWLNDQKK","928016","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0891 (bglB); SMu0893 (bglC); SMu0895 (bglA); SMu1007 (bglA); SMu1285 (bglC); SMu1454 (bglG) and SMu1456 (bglA).SMu0891 and SMu0892 either represent one gene with a frameshift or a pseudogene.","beta-glucosidase, BglB protein","Extracellular","Matches in gapped BLAST only to beta-glucoside from S.mutans: residues 1-185 are 91% similar to the protein in (gi|9622920|). SMu0892 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF53474	$\"[1-109]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 21-185 are 90% similar to a (BGLB) protein domain (PD304507) which is seen in Q9KJ79_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 26 16:43:07 2002","Mon Oct 14 18:10:02 2002","Mon Oct 14 18:10:02 2002","Tue Jan 8 10:20:35 2002","","Tue Jan 8 10:20:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0892 is paralogously related (blast p-value < 1e-3) to SMu0700, a predicted BglB-like protein.","Thu Mar 21 09:16:23 2002","","No significant hits to the NCBI PDB database.","SMU.982","","No significant hits to the Pfam 11.0 database","Tue Jan 8 10:20:35 2002","24379422","","Cote CK, Honeyman AL. The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549 Cote,C.K., Cvitkovitch,D., Bleiweis,A.S. and Honeyman,A.L. A novel beta-glucoside-specific PTS locus from streptococcus mutans that is not inhibited by glucose Microbiology 146 (Pt 7), 1555-1563 (2000) PubMed: 10878120","","Sat Oct 26 16:43:07 2002","","1","","","SMU.982","" "SMu0893","929155","928250","906","ATGGAAAGAATGAAAGCATTTTTAACAGATGAAAATTTTAAGCATGAGATTAACTTTGATAATGATTTACTACCTTATAAAATTTATCAAACAACTATTGCTAATGGCTATCCAGATGCCCTTTTTCATTGGCATCCAGAATTAGAAATTTCTTATATTTATGAAGGTACAGCTCAATATCACATTGATTATGATTATTTTAATAGCCAAACTGATGATATTATTCTTGTCCGTCCCAATGGTATGCATTCTATTCACCCTATCAAAAATAAAATGCAAAAAGCTCAGACACTACTTTTCCATTTAGATTTGGTTGGCTATTCTCTTTTGGATCAAATTAGTCTTCGTTATTTGCAACCTTTGCAAAACTCTACTTTTAAACTTGTCCCTTGTATCAAGCCAGACATGTTAGGTTACCAGGATATCAAAAATTGTCTTTTTGCTATTTTCGATATTTATCAGCGACAAGGACGCCATTTTGAACTCTTACTCAAGGCAAAATTACAAGAATTAATCTATCTTCTCTACTTTCATCAATACGTCCTGCGAAAGCATTCTGATGATATGTATCGTAAAAATGAGAAAATTCGTGAATTGATTGATTATATTCATCAGCATTATCAAGAAAAATTGTTTATTATCTCTTTAGCTGATATTATCGGTTATAGCAAAACTCATTTTATGACAGTTTTTAAACAACATACTGGAACCTCCTGCACAGATTTTATTATTCAATTCCGACTGAGTAAAGCCTGTGATTTATTAGTCAATTCCATTAAACCAATTCTTGAAGTTGCTTCCGAAGTTGGCTTTACTAACCTCTCTAATTTTAATCGCCAATTTAAACGTTATTATCAAATTACTCCAAGTCAATATCGTAAACAGTTCAAAAAGACACAAAAATAG","8.80","7.18","36034","MERMKAFLTDENFKHEINFDNDLLPYKIYQTTIANGYPDALFHWHPELEISYIYEGTAQYHIDYDYFNSQTDDIILVRPNGMHSIHPIKNKMQKAQTLLFHLDLVGYSLLDQISLRYLQPLQNSTFKLVPCIKPDMLGYQDIKNCLFAIFDIYQRQGRHFELLLKAKLQELIYLLYFHQYVLRKHSDDMYRKNEKIRELIDYIHQHYQEKLFIISLADIIGYSKTHFMTVFKQHTGTSCTDFIIQFRLSKACDLLVNSIKPILEVASEVGFTNLSNFNRQFKRYYQITPSQYRKQFKKTQK","928255","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0891 (bglB); SMu0892 (bglB); SMu0895 (bglA); SMu1007 (bglA); SMu1285 (bglC); SMu1454 (bglG) and SMu1456 (bglA).","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulator:residues 1-301 are 99% similar to the previously published protein in S.mutans (gi9622921).Residues 23-294 are 26% similar to transcriptional regulator inB.halodurans (gi10174524).Residues 4-294 are 23% similar to theprotein in B.subtilis (gi16077582). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1106 (1e-121).","

InterPro
IPR000005
Domain

Helix-turn-helix, AraC type
PR00032	$\"[262-277]T$ $\"[277-293]T$	HTHARAC
PF00165	$\"[198-244]T$ $\"[250-294]T$	HTH_AraC
SM00342	$\"[210-293]T$	HTH_ARAC
PS00041	$\"[247-289]T$	HTH_ARAC_FAMILY_1
PS01124	$\"[197-295]T$	HTH_ARAC_FAMILY_2

InterPro
IPR003313
Domain

AraC protein, arabinose-binding/dimerisation
PF02311	$\"[27-178]T$	AraC_binding
SSF51215	$\"[9-179]T$	AraC_binding

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[192-245]T$ $\"[246-296]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[192-244]T$ $\"[246-294]T$	Homeodomain-rel

noIPR
unintegrated

unintegrated
PTHR11019	$\"[179-295]T$	PTHR11019
PTHR11019:SF11	$\"[179-295]T$	PTHR11019:SF11

","BeTs to 5 clades of COG2207COG name: AraC-type DNA-binding domain-containing proteinsFunctional Class: KThe phylogenetic pattern of COG2207 is ------vCEBRH---------Number of proteins in this genome belonging to this COG is 3","***** IPB000005 (AraC type helix-turn-helix) with a combined E-value of 4.8e-15. IPB000005 262-293 IPB000005 212-243","Residues 200-292 are 41% similar to a (TRANSCRIPTION DNA-BINDING REGULATION) protein domain (PD402035) which is seen in O52770_PSEFL.Residues 211-285 are 58% similar to a (TRANSCRIPTION REGULATION DNA-BINDING TRANSCRIPTIONAL) protein domain (PD000394) which is seen in Q9F4J7_STRMT.Residues 43-86 are 45% similar to a (GERMIN-LIKE PROTEOME COMPLETE PRECURSOR) protein domain (PD000728) which is seen in Q9F4J7_STRMT.Residues 101-195 are identical to a (TRANSCRIPTIONAL PBLR REGULATION REGULATOR) protein domain (PD310734) which is seen in Q9KJ78_STRMU.Residues 23-172 are 22% similar to a (PROTEOME TRANSCRIPTIONAL REGULATION) protein domain (PD103972) which is seen in Q9KBM0_BACHD.Residues 196-293 are 98% similar to a (DNA-BINDING TRANSCRIPTION REGULATION TRANSCRIPTIONAL) protein domain (PD385094) which is seen in Q9KJ78_STRMU.Residues 1-100 are 99% similar to a (TRANSCRIPTIONAL REGULATION REGULATOR) protein domain (PD393990) which is seen in Q9KJ78_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 31 15:59:12 2006","Tue Jan 8 10:22:58 2002","Mon Jul 31 15:59:12 2006","Tue Jan 8 10:22:58 2002","Tue Jan 8 10:22:58 2002","Tue Jan 8 10:22:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0893 is paralogously related (blast p-value < 1e-3) to SMu0799,a predicted MSM operon regulatory protein, and to SMu1285, a predicted transcription regulator.","Mon Jan 14 08:28:40 2002","Mon Jul 31 15:59:12 2006","pdb1D5YA Chain A, Crystal Structure Of The E. Coli Rob Transc... 64 3e-011pdb1BL0A Chain A, Multiple Antibiotic Resistance Protein (Mar... 64 3e-011","SMU.983c","","Residues 27 to 178 (E-value = 1.5e-24) place SMu0893 in the AraC_binding family which is described as AraC-like ligand binding domain (PF02311)Residues 198 to 244 (E-value = 9.5e-07) place SMu0893 in the HTH_AraC family which is described as Bacterial regulatory helix-turn-helix proteins, araC family (PF00165)Residues 250 to 294 (E-value = 1.2e-11) place SMu0893 in the HTH_AraC family which is described as Bacterial regulatory helix-turn-helix proteins, araC family (PF00165)","Mon Jul 31 15:59:12 2006","","","Cote CK, Honeyman AL. The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549 Cote,C.K., Cvitkovitch,D., Bleiweis,A.S. and Honeyman,A.L. A novel beta-glucoside-specific PTS locus from streptococcus mutans that is not inhibited by glucose Microbiology 146 (Pt 7), 1555-1563 (2000) PubMed: 10878120Cote CK, Honeyman AL.The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549","","Sat Oct 26 16:43:37 2002","","1","","","SMU.983c","684" "SMu0894","929340","929840","501","ATGATTAGCAGACAGCAAAAAATGACATTTAAAGAGATTAAGGATGGGGAAATGGAAGAAAGAGATATTCTTTTAACTGGTTTTTACAATGTTAGATTAAATAGCGTTCAAGAAGCTAGGTTGACTTACAATTTACCAAACGATCAAACCGTGAAATTTGGCTTTGATGGCAATGGTTATAGCTATGGAAGTGATTTTTGGTATATTTATAATAGAACAGCTCAGTTAGGTAAGGAAATTAGTTCTCATTTAGATGAAAACGCTAGTAAATGGATAGAAGAAGCAGGTCAGAAAGGCTATACAACGGGTAATCAGGCAAAAGTTGGAGCTATAGCCTGCTTACCTTCTTATCTATCTGATGCAGAGTCTTCTAGTCATCTTGCTTTTGTAGAATATCTTAATAGCGATGGCAGTTTTATTGTGAGTGAAATGCCCAGCCCCAATATTCTCAATTGGCGTCTTATACAGCCTCAATCAAAAATGACTTTTATTTATCTTTAA","4.90","-4.57","18896","MISRQQKMTFKEIKDGEMEERDILLTGFYNVRLNSVQEARLTYNLPNDQTVKFGFDGNGYSYGSDFWYIYNRTAQLGKEISSHLDENASKWIEEAGQKGYTTGNQAKVGAIACLPSYLSDAESSSHLAFVEYLNSDGSFIVSEMPSPNILNWRLIQPQSKMTFIYL","929839","","hypothetical protein","Extracellular, Cytoplasm","Matches in gapped BLAST to unknown protein:residues 1-137 are 98%similar to the previously published protein in S.mutans (gi|9622922|). Residues 14-166 are 30% similar to the protein from S.aureus (gi|15923455|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1286 (1e-09).","

InterPro
IPR007921
Domain

Cysteine, histidine-dependent amidohydrolase/peptidase
PF05257	$\"[46-165]T$	CHAP
PS50911	$\"[40-165]T$	CHAP

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 58-144 are 35% similar to a (PRECURSOR SIGNAL PLASMID SECRETED) protein domain (PD012961) which is seen in Q9CED5_LACLA.Residues 1-137 are 98% similar to a (DOMAIN OF UNKNO N) protein domain (PD298606) which is seen in Q9KJ77_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 14:51:15 2002","Tue Jan 8 10:37:52 2002","Mon Jan 28 14:52:41 2002","Tue Jan 8 10:37:52 2002","","Tue Jan 8 10:37:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0894 is paralogously related (blast p-value < 1e-3) to SMu0176, a predicted immunogenic secreted protein (transfer protein).","Mon Jan 28 14:50:10 2002","","No significant hits to the NCBI PDB database.","SMU.984","","Residues 46 to 165 (E-value = 6.4e-09) place SMu0894 in the CHAP family which is described as CHAP domain (PF05257)","Tue Jan 8 10:37:52 2002","24379424","","","","Thu Mar 21 09:18:06 2002","","1","","","SMU.984","" "SMu0895","929971","931410","1440","ATGATGTCATACACATTTCCAGAAAATTTTTTATGGGGTGGTGCAACAGCTGCCAATCAGTTTGAAGGTGCTTATAATCAAGATGGTAAGGGCTTATCCGTTCAAGATGTTACGCCAAAAGGAGGAGTTACTCAATCTGGTTCTTCAAGTCCATTGATTACTGAAAAACCAACGGAAGATAACCTTAAATTAGTTGGTATTGATTTTTATAATCGTTATAAAGAAGATATTGCTCTTTTTGCTGAAATGGGTTTTAAGGTATTTCGTCTTTCTATTGCCTGGACTCGTATCTTTCCAAATGGTGATGATCTAGAACCAAACGAAGCCGGACTTGCCTTTTATGATAAAGTTTTTGATGAACTGGCAAAATATGATATTGAACCATTGGTTACCTTATCGCATTATGAAACACCTCTTCATTTGGCTAGAAAATATAATGGGTGGGCAAATCGTGAGTTAATTGCTTTTTATGAACGTTATGCACGCACAGTATTCACACGTTATAAAGATAAGGTGAAATATTGGCTAACTTTTAATGAAGTCAATTCTGTTTTACATGCGCCGTTTATGTCAGGAGGTATCATTACCGATCCCGAACAATTAAGCAAACAAGATCTTTATCAAGCCGTTCATCATGAATTAGTGGCATCTGCTCTTGCAACTAAAGTTGGTCATGAAATCAATCCGGATTTTAAAATTGGCTGTATGGTTCTTGCTATGCCTGCTTATCCAATGCCTGCAGATCCATTAGATCAATTAGCTGTTCGAGAGTTTGAAAATCAAAATTATCTATTTAGTGACTTACATGCACGAGGGAAATACCCTAACTATATTAAACGTTATTTCAAGGACAATAATATTGACATTCAAATGGCTGAAGGTGACAAGGAGCTAATGCTCGAAAATACTGTTGATTTTATTTCTTTCTCTTACTATATGTCAGTAGCAGCAGCTCATAATCCTGAAGACTACAATTCAGGAAGAGGTAATGTCTTGGGAGGTCTTTCAAATCCTTATCTTCAAGCTTCAGAATGGGGTTGGCAAATTGATCCTGTTGGTTTACGTCTAGTTCTTAATGACTTTTATGATCGTTATCAATTACCACTCTTTATTGTAGAAAATGGTCTAGGTGCCAAAGATGTTCTTGTTCAAGGACCAGATGGACCGACCGTTGAAGACGATTACCGTATTGATTATCTTCAAAAACACTTGATGCAAGTAGGAGAAGCCCTGCAAGATGGTGTAGACTTACTTGGTTATACAACTTGGGGGCCAATAGATCTTGTTTCTGCATCAACTGCAGAACTTAGTAAACGCTATGGTTTTATCTATGTTGATCGCAACGATGATGGTTCTGGAAGTTTGGTACGCTATAAGAAAAAATCATTTGCTTGGTATAAAAAGGTTATTGAAACTAATGGTGCCAGCCTCTATGAATGA","4.70","-18.84","54352","MMSYTFPENFLWGGATAANQFEGAYNQDGKGLSVQDVTPKGGVTQSGSSSPLITEKPTEDNLKLVGIDFYNRYKEDIALFAEMGFKVFRLSIAWTRIFPNGDDLEPNEAGLAFYDKVFDELAKYDIEPLVTLSHYETPLHLARKYNGWANRELIAFYERYARTVFTRYKDKVKYWLTFNEVNSVLHAPFMSGGIITDPEQLSKQDLYQAVHHELVASALATKVGHEINPDFKIGCMVLAMPAYPMPADPLDQLAVREFENQNYLFSDLHARGKYPNYIKRYFKDNNIDIQMAEGDKELMLENTVDFISFSYYMSVAAAHNPEDYNSGRGNVLGGLSNPYLQASEWGWQIDPVGLRLVLNDFYDRYQLPLFIVENGLGAKDVLVQGPDGPTVEDDYRIDYLQKHLMQVGEALQDGVDLLGYTTWGPIDLVSASTAELSKRYGFIYVDRNDDGSGSLVRYKKKSFAWYKKVIETNGASLYE","931409","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0891 (bglB); SMu0892 (bglB); SMu0893 (bglC); SMu1007 (bglA); SMu1285 (bglC); SMu1454 (bglG) and SMu1456 (bglA).","6-phospho-beta-glucosidase","Cytoplasm, Extracellular","Matches in gapped BLAST to beta-glucoside:residues 1-479 are 97%similar to the previously published protein in S.mutans (gi9622923). Residues 6-477 are 72% similar to the enzyme from S.pyogenes (gi15674663).Residues 5-471 are 71% similar to phospho-beta-glucosidase from Clostridium longisporum (gi2494810).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0791 (0.0).","

InterPro
IPR001360
Family

Glycoside hydrolase, family 1
PR00131	$\"[303-317]T$ $\"[369-377]T$ $\"[393-404]T$ $\"[414-431]T$ $\"[439-451]T$	GLHYDRLASE1
PTHR10353	$\"[5-479]T$	Glyco_hydro_1
PF00232	$\"[2-475]T$	Glyco_hydro_1
PS00572	$\"[369-377]T$	GLYCOSYL_HYDROL_F1_1
PS00653	$\"[10-24]T$	GLYCOSYL_HYDROL_F1_2

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[3-474]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
PTHR10353:SF3	$\"[5-479]T$	PTHR10353:SF3
SSF51445	$\"[3-474]T$	SSF51445

","No hits to the COGs database.","***** IPB001360 (Glycoside hydrolase family 1) with a combined E-value of 9.2e-56. IPB001360A 6-24 IPB001360B 68-101 IPB001360C 264-275 IPB001360D 305-314 IPB001360E 413-440 IPB001360B 130-163","Residues 204-296 are 29% similar to a (BGLB PHOSPHO-BETA-GLUCOSIDASE) protein domain (PD295003) which is seen in Q9X564_ENTFC.Residues 40-185 are 23% similar to a (HYDROLASE LACTASE ZYMOGEN PRECURSOR) protein domain (PD018129) which is seen in LPH_RAT.Residues 113-180 are 50% similar to a (BGLB PHOSPHO-BETA-GLUCOSIDASE) protein domain (PD350257) which is seen in Q9X564_ENTFC.Residues 65-101 are 81% similar to a (BETA-GLUCOSIDASE HYDROLASE AMYGDALASE) protein domain (PD235643) which is seen in O50658_BBBBB.Residues 2-36 are 60% similar to a (BETA-GLUCOSIDASE PROTEOME AMYGDALASE) protein domain (PD409239) which is seen in BGLS_CALSA.Residues 5-43 are 71% similar to a (II PHOSPHO-BETA-GALACTOSIDASE) protein domain (PD246278) which is seen in O50658_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 13:29:48 2007","Thu Sep 28 11:11:56 2006","Thu Sep 28 11:11:56 2006","Tue Jan 8 10:40:55 2002","Tue Jan 8 10:40:55 2002","Tue Jan 8 10:40:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0895 is paralogously related (blast p-value < 1e-3) to SMu1007, SMu1456,and SMu1355, all predicted phospho-beta-glucosidases .","Mon Jan 28 14:57:01 2002","Thu Sep 28 11:11:56 2006","pdb1BGGA Chain A, Glucosidase A From Bacillus Polymyxa Comple... 240 4e-064pdb1TR1A Chain A, Crystal Structure Of E96k Mutated Beta-Gluc... 239 7e-064pdb1BGAA Chain A, Beta-Glucosidase A From Bacillus Polymyxa >... 239 7e-064","SMU.985","","Residues 2 to 475 (E-value = 2.5e-156) place SMu0895 in the Glyco_hydro_1 family which is described as Glycosyl hydrolase family 1 (PF00232)","Tue Jan 8 10:40:55 2002","24379425","","Cote CK, Honeyman AL. The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549 Cote,C.K., Cvitkovitch,D., Bleiweis,A.S. and Honeyman,A.L. A novel beta-glucoside-specific PTS locus from streptococcus mutans that is not inhibited by glucose Microbiology 146 (Pt 7), 1555-1563 (2000) PubMed: 10878120Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ.Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 93015655Honeyman,A.L. and Curtiss,R. III.Isolation, characterization and nucleotide sequence of theStreptococcus mutans lactose-specific enzyme II (lacE) gene of thePTS and the phospho-beta-galactosidase (lacG) geneJ. Gen. Microbiol. 139 (Pt 11), 2685-2694 (1993)PubMed: 8277252Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337","Brown,G.D. and Thomson,J.A.Isolation and characterisation of an aryl-beta-D-glucoside uptakeand utilisation system (abg) from the gram-positive ruminalClostridium species C. longisporumMol. Gen. Genet. 257 (2), 213-218 (1998)PubMed: 9491080Le Coq,D., Lindner,C., Kruger,S., Steinmetz,M. and Stulke,J.New beta-glucoside (bgl) genes in Bacillus subtilis: the bglP geneproduct has both transport and regulatory functions similar tothose of BglF, its Escherichia coli homologJ. Bacteriol. 177 (6), 1527-1535 (1995)PubMed: 7883710","Tue Apr 24 13:29:48 2007","Tue Jan 8 10:44:37 2002","1","","","SMU.985","" "SMu0896","932013","931498","516","ATGCCAAAAAGAATTCAATATTCAAATCAGAAATTTAAAATATTACAAGCAAATCTCTCATCTATTCGAAATATAGCTAATTGGACAGCTAAAGAGTTGGGAGCTAAAATTGGTGTTACCAAACAAACCATTAGTAATCTTGAAAATTCTAATGGACAAACAAATAATTTAAATTCCACACAATATCTTGCCATTCGTTCTGTCATTGATCATGAAATTACTATTACTGATAACCCTGTTTTAAAAAAAACAATGGACTACTTATTCAACCAAGAACAAGACAATATAGATTCAAACATAAAGTTGAAATCGGCTAAAGATATAAAAATCGCACAACTTGGAGCCGCATCAAAAGCTGCATATACTTCTCAGATAAAAAACAGTGAACAGACAAATCTAGAGAGAAAAACAATGGCTGTTTTCGCTTTGCTTCCTTTAACTACTTCTATTTTGGGTTCTACCACCTCTACTTATAAGCCCTTTTCCTTTTTTGATGACGTTATTCCTCCTTGCTAA","10.20","6.18","19047","MPKRIQYSNQKFKILQANLSSIRNIANWTAKELGAKIGVTKQTISNLENSNGQTNNLNSTQYLAIRSVIDHEITITDNPVLKKTMDYLFNQEQDNIDSNIKLKSAKDIKIAQLGAASKAAYTSQIKNSEQTNLERKTMAVFALLPLTTSILGSTTSTYKPFSFFDDVIPPC","931503","","conserved hypothetical protein","Periplasm, Extracellular","A weak match in gapped BLAST to Bifidobacterium longum NCC2705: residues 16-166 are 25% similar to a fragment of this bacterium.SMu0896 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[19-49]T$	HTH_3

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[12-49]T$	Lambda_like_DNA

InterPro
IPR001899
Domain

Surface protein from Gram-positive cocci, anchor region
PF00746	$\"[414-453]T$	Gram_pos_anchor
TIGR01167	$\"[421-453]T$	LPXTG_anchor
PS50847	$\"[422-453]T$	GRAM_POS_ANCHORING

InterPro
IPR008456
Domain

Collagen binding
PF05737	$\"[179-316]T$	Collagen_bind

InterPro
IPR008966
Domain

Bacterial adhesion
SSF49401	$\"[33-159]T$ $\"[177-331]T$	Adhes_bact

noIPR
unintegrated

unintegrated
G3DSA:2.60.40.1280	$\"[29-182]T$	G3DSA:2.60.40.1280

","No hits to the COGs database.","***** IPB002889 (WSC domain) with a combined E-value of 9.7e-06. IPB002889B 345-391 IPB002889B 353-399 IPB002889B 340-386 IPB002889B 338-384 IPB002889B 349-395 IPB002889B 364-410 IPB002889B 343-389 IPB002889B 332-378 IPB002889B 331-377 IPB002889B 339-385 IPB002889B 346-392 IPB002889B 347-393 IPB002889B 358-404 IPB002889B 350-396 IPB002889B 357-403 IPB002889B 368-414 IPB002889B 344-390 IPB002889B 334-380 IPB002889B 352-398 IPB002889B 336-382 IPB002889B 351-397 IPB002889B 348-394 IPB002889B 354-400 IPB002889B 362-408 IPB002889B 363-409 IPB002889B 342-388 IPB002889B 355-401 IPB002889B 333-379 IPB002889B 359-405 IPB002889B 365-411 IPB002889B 337-383 IPB002889B 325-371 IPB002889B 360-406 IPB002889B 366-412 IPB002889B 324-370 IPB002889B 330-376 IPB002889B 356-402 IPB002889B 367-413 IPB002889B 373-419 IPB002889B 320-366 IPB002889B 335-381 IPB002889B 378-424 IPB002889B 329-375 IPB002889B 317-363 IPB002889B 372-418 IPB002889B 382-428 IPB002889B 361-407 IPB002889B 369-415 IPB002889C 368-389 IPB002889C 367-388 IPB002889C 370-391 IPB002889C 348-369 IPB002889C 355-376 IPB002889C 354-375","Residues 83-315 are identical to a (PROTEOME COMPLETE BH0361 BH2014) protein domain (PD343571) which is seen in WAPA_STRMU.Residues 1-82 are 85% similar to a (ALL PRECURSOR ALL-ASSOCIATED SIGNAL) protein domain (PD049416) which is seen in WAPA_STRMU.Residues 316-453 are 31% similar to a (ALL PRECURSOR ALL-ASSOCIATED SIGNAL) protein domain (PD397082) which is seen in WAPA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 15:07:29 2002","Tue Mar 27 12:53:46 2007","Tue Mar 27 12:53:46 2007","Tue Jan 8 10:57:46 2002","Tue Jan 8 10:57:46 2002","Tue Jan 8 10:57:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0897 is paralogously related (blast p-value < 1e-3) to SMu1947, a predicted surface protein; SMu1843, a predicted levansucrase (fructosyltransferase) (beta-D-fructofuranosyl transferase); SMu0915, a predicted glucosyltransferase-SI; SMu0625 and SMu0057, both predicted conserved hypothetical proteins; SMu1935,a predicted conserved hypothetical protein (possible transmembrane protein); and SMu0827, a predicted glucosyltransferase-S.","Mon Jan 28 15:05:23 2002","","No significant hits to the NCBI PDB database.","SMU.987","","Residues 179 to 316 (E-value = 2.6e-45) place SMu0897 in the Collagen_bind family which is described as Collagen binding domain (PF05737)Residues 414 to 453 (E-value = 6.6e-09) place SMu0897 in the Gram_pos_anchor family which is described as Gram positive anchor (PF00746)","Tue Mar 27 12:53:46 2007","24379427",""," Zhu L, Kreth J, Cross SE, Gimzewski JK, Shi W, Qi F.,Functional characterization of cell-wall-associated protein WapA in Streptococcus mutans.Microbiology. 2006 Aug;152(Pt 8):2395-404.PMID: 16849803Han TK, Yoder S, Cao C, Ugen KE, Dao ML.Expression of Streptococcus mutans wall-associated protein A gene in Chinesehamster ovary cells: prospect for a dental caries DNA vaccine.DNA Cell Biol. 2001 Sep;20(9):595-601.PMID: 11747611Ferretti,J.J., Russell,R.R. and Dao,M.L.Sequence analysis of the wall-associated protein precursor ofStreptococcus mutans antigen AMol. Microbiol. 3 (4), 469-478 (1989)PubMed: 2761387","Freudl,R. and Cole,S.T.Cloning and molecular characterization of the ompA gene fromSalmonella typhimuriumEur. J. Biochem. 134 (3), 497-502 (1983)PubMed: 6349993","Tue Mar 27 12:53:46 2007","Mon Oct 14 18:15:19 2002","1","","","SMU.987","" "SMu0898","934040","935425","1386","ATGATAGGATCTGTTCTTTATCTTGTGAATAGTCAGATGGATACGCTTTCGATTATTACTTGGCTTTTGGTTATTTTGCCTTTTCCTATTTTAGGAACACTTTTTTTAATCTATACAAAGCAAGATTGGGGTTATCGTGAGTTGAAATCGCTTATCAAAAAATCAACACAAGCTATTAAACCTTATTTTCAGTATGATCAACGTATTTTGTATAAACTAAAAGAAAGTCACGCTAGAACTTATAATTTAGCCCAATATCTCCATAGAAGCGGAGGATTTCCTGTTTACAAAAACACCAAAGTCACGTACTTTCCGAATGGACAATCTAAATTTGAAGAGATGAAAAAACAGTTGCTAAAAGCTGAAAAATTCATCTTTTTAGAATATTTCATTATAGCTGAAGGATTGATGTGGGGTGAAATTCTTTCTATTTTAGAACAAAAAGTTCAAGAAGGAGTAGAAGTTAGGGTGATGTATGATGGCATGTTAGAATTATCAACGCTTTCTTTTGACTATGCTAAAAGACTGGAAAAAATTGGGATAAAAGCCAAGGTTTTTTCACCCATAACTCCATTTGTGTCTACCTATTACAATTACCGAGACCATCGTAAAATTTTAGTTATTGATAATAAGGTCGCTTTTAATGGGGGGATTAATCTTGCGGATGAATATATCAATCAAATTGAACGATTTGGTTACTGGAAAGATACTGCTGTTATGCTGGAAGGTGAAGGTGTCGCTTCTTTTACTTTAATGTTTTTACAAATGTGGTCTACTACCAATAAAGATTATGAATTTGCACCTTATTTAACCCAAAATTTTCATGAGATTGTTGCTAATGGTTATGTCATTCCCTACAGTGATTCACCGCTTGACCATGAAAAAGTAGGTGAAAATGTTTACATTGATATCCTCAATCAAGCGCGGGATTATGTTTACATTATGACGCCTTATTTAATTTTAGATAGTGAAATGGAGCATGCTTTACAATTTGCTGCTGAACGTGGTGTTGATGTTAAAATTATTATGCCAGGTATTCCTGATAAGAAGGTTCCCTTTGCCTTAGCTAAGCGCTATTTTCCTGCTCTTCTTGATGCGGGAGTCAAGATTTATGAATTCACGCCAGGATTTGTACATGCTAAAGTTTTTATAGCTGATGATATAAAAGCAGTAGTAGGGACAATAAACTTAGATTATCGTAGTCTTTATCATCATTTTGAATGTGCGACTTATATGTATCAGACGGATTGTCTTGTTGATATTAAAGCCGATTTTAAAGAAACTTTAAAACAATCAAGACGAGTAACACGATCAACTTTACAAAAAGAAAAAATTTCGACAAAATTAATTGGTTTGGTTGTTAAGTTGGTAGCCCCCCTCTTGTGA","8.50","4.10","53396","MIGSVLYLVNSQMDTLSIITWLLVILPFPILGTLFLIYTKQDWGYRELKSLIKKSTQAIKPYFQYDQRILYKLKESHARTYNLAQYLHRSGGFPVYKNTKVTYFPNGQSKFEEMKKQLLKAEKFIFLEYFIIAEGLMWGEILSILEQKVQEGVEVRVMYDGMLELSTLSFDYAKRLEKIGIKAKVFSPITPFVSTYYNYRDHRKILVIDNKVAFNGGINLADEYINQIERFGYWKDTAVMLEGEGVASFTLMFLQMWSTTNKDYEFAPYLTQNFHEIVANGYVIPYSDSPLDHEKVGENVYIDILNQARDYVYIMTPYLILDSEMEHALQFAAERGVDVKIIMPGIPDKKVPFALAKRYFPALLDAGVKIYEFTPGFVHAKVFIADDIKAVVGTINLDYRSLYHHFECATYMYQTDCLVDIKADFKETLKQSRRVTRSTLQKEKISTKLIGLVVKLVAPLL","935424","","cardiolipin synthase","Cytoplasm, Extracellular","Matches in gapped BLAST to hypothetical protein (wapA 3' region) :residues 1-373 are 100% similar to the previously published protein in S.mutans (gi466181).Residues 5-461 are 65% similar to cardiolipin synthetase from S.pyogenes (gi15675176).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1054 (1e-175).","

InterPro
IPR001736
Domain

Phospholipase D/Transphosphatidylase
PF00614	$\"[197-224]T$ $\"[374-401]T$	PLDc
SM00155	$\"[197-224]T$ $\"[374-401]T$	PLDc
PS50035	$\"[197-224]T$ $\"[374-401]T$	PLD

noIPR
unintegrated

unintegrated
G3DSA:3.30.870.10	$\"[96-258]T$ $\"[283-439]T$	G3DSA:3.30.870.10
PIRSF006046	$\"[1-461]T$	PLD_CLS
PTHR21248	$\"[233-449]T$	PTHR21248

","BeTs to 6 clades of COG1502COG name: Cardiolipin synthase, phoaphatidylserine synthase and related enzymes of the phospholipase D familyFunctional Class: IThe phylogenetic pattern of COG1502 is a---y-vcEB-hUJ----INxNumber of proteins in this genome belonging to this COG is 1","***** IPB001736 (Phospholipase D/Transphosphatidylase) with a combined E-value of 3.8e-06. IPB001736B 379-398 IPB001736B 202-221","Residues 118-449 are 36% similar to a (CARDIOLIPIN SYNTHASE PROTEOME COMPLETE) protein domain (PD404266) which is seen in CLS_BACFI.Residues 112-236 are 30% similar to a (PHOSPHOLIPASE) protein domain (PD323854) which is seen in PLD1_HUMAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 15:09:43 2002","Fri Apr 26 14:46:15 2002","Tue Sep 12 15:08:16 2006","Tue Jan 8 13:52:17 2002","Tue Jan 8 13:52:17 2002","Tue Jan 8 13:52:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0898 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 13:53:07 2002","","No significant hits to the NCBI PDB database.","SMU.988","","Residues 197 to 224 (E-value = 1.3e-09) place SMu0898 in the PLDc family which is described as Phospholipase D. Active site motif (PF00614)Residues 374 to 401 (E-value = 3.1e-06) place SMu0898 in the PLDc family which is described as Phospholipase D. Active site motif (PF00614)","Tue Sep 12 15:08:16 2006","24379428","","Ferretti,J.J., Russell,R.R. and Dao,M.L.Sequence analysis of the wall-associated protein precursor ofStreptococcus mutans antigen AMol. Microbiol. 3 (4), 469-478 (1989)PubMed: 2761387","","Mon Jan 28 15:08:08 2002","","1","","","SMU.988","364" "SMu0899","935710","936786","1077","ATGGGCTACACAGTTGCTATCGTTGGTGCTACAGGCGCCGTTGGAACTCGTATGATTCAACAATTGGAACAATCGACACTTCCAGTTGACAAGGTACGGCTTTTGTCATCTTCACGTTCTGCAGGTAAAGTTTTGCAATATAAAGATCAAGATGTCACGGTTGAATTAACTACGAAAGATTCCTTTGAAGGTGTTGATATTGCGCTTTTTTCAGCTGGCGGTTCTGTTTCGGCAAAATTTGCTCCCTATGCAGTCAAAGCTGGTGCAGTCGTTGTTGATAATACCTCTCATTTTCGTCAAAATCCAGATGTGCCTTTGGTTGTTCCTGAAGTCAATGCTTATGCTATGGATGCTCATAATGGGATTATTGCTTGTCCTAACTGCTCAACGATTCAAATGATGGTAGCCTTGGAACCTATTCGTCAAAAATGGGGATTAAGTCGTGTTATTGTTTCAACCTATCAAGCTGTTTCAGGAGCAGGTCAATCAGCTATTAATGAAACTGTTCGTGAAATTAAAGAAGTTGTTAATGATGGTGTGGATCCTAAAGCTGTTCATGCTGATATTTTGCCATCAGGTGGTGATAAAAAGCATTATCCAATTGCTTTCAATGCTTTGGCACAGATTGATGTCTTCACCGATAATGATTATACTTATGAAGAAATGAAGATGACTAACGAAACCAAGAAAATCATGGAAGAACCTGAACTTCCCGTTTCGGCCACTTGTGTTCGTGTTCCAATCCTTTTTTCACATTCTGAGGCTGTTTATATTGAAACTAAAGACGTTGCTCCAATTGAAGAAGTAAAAGCAGCTATTGCAGCATTTCCAGGTGCTGTTCTTGAAGATGATATTAAACATCAAATTTACCCACAAGCAGCGAATGCTGTTGGCAGTCGTGAAACTTTTGTCGGCCGTATTCGTAAGGATTTAGATATTGAAAATGGTATTCATATGTGGGTCGTTTCAGACAATCTTCTTAAAGGTGCTGCTTGGAATTCAGTTCAAATTGCTGAAAGTCTTCATGAACGTGGTCTTGTTCGTTCGACATCAGAATTGAAGTTTGAACTGAAATAA","5.10","-10.19","38891","MGYTVAIVGATGAVGTRMIQQLEQSTLPVDKVRLLSSSRSAGKVLQYKDQDVTVELTTKDSFEGVDIALFSAGGSVSAKFAPYAVKAGAVVVDNTSHFRQNPDVPLVVPEVNAYAMDAHNGIIACPNCSTIQMMVALEPIRQKWGLSRVIVSTYQAVSGAGQSAINETVREIKEVVNDGVDPKAVHADILPSGGDKKHYPIAFNALAQIDVFTDNDYTYEEMKMTNETKKIMEEPELPVSATCVRVPILFSHSEAVYIETKDVAPIEEVKAAIAAFPGAVLEDDIKHQIYPQAANAVGSRETFVGRIRKDLDIENGIHMWVVSDNLLKGAAWNSVQIAESLHERGLVRSTSELKFELK","936785","","aspartate-semialdehyde dehydrogenase","Cytoplasm","Matches in gapped BLAST to aspartate-semialdehyde dehydrogenase :residues 1-358 are 97% similar to the previously published protein in S.mutans (gi|118511|). Residues 1-358 are 82% similar to the enzyme from S.pneumoniae (gi|15900885|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1051 (1e-157).","

InterPro
IPR000319
Domain

Aspartate-semialdehyde dehydrogenase, conserved region
PS01103	$\"[239-253]T$	ASD

InterPro
IPR000534
Domain

Semialdehyde dehydrogenase, NAD - binding
PF01118	$\"[4-119]T$	Semialdhyde_dh

InterPro
IPR005986
Family

Aspartate-semialdehyde dehydrogenase, bacterial
TIGR01296	$\"[4-344]T$	asd_B

InterPro
IPR012080
Family

Aspartate-semialdehyde dehydrogenase
PIRSF000148	$\"[2-347]T$	ASA_dh

InterPro
IPR012280
Domain

Semialdehyde dehydrogenase, dimerisation region
PF02774	$\"[137-328]T$	Semialdhyde_dhC

noIPR
unintegrated

unintegrated
G3DSA:3.30.360.10	$\"[127-342]T$	G3DSA:3.30.360.10
PTHR10174	$\"[5-167]T$ $\"[199-346]T$	PTHR10174
PTHR10174:SF2	$\"[5-167]T$ $\"[199-346]T$	PTHR10174:SF2
SSF51735	$\"[3-142]T$	SSF51735
SSF55347	$\"[127-329]T$	SSF55347

","BeTs to 14 clades of COG0136COG name: Aspartate-semialdehyde dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0136 is amtkyqvcEbrHuj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB000319 (Aspartate-semialdehyde dehydrogenase) with a combined E-value of 5.5e-95. IPB000319A 5-16 IPB000319B 35-44 IPB000319C 63-79 IPB000319D 91-112 IPB000319E 151-161 IPB000319F 220-233 IPB000319G 239-259 IPB000319H 291-310 IPB000319I 324-338***** IPB000534 (Semialdehyde dehydrogenase) with a combined E-value of 1.8e-15. IPB000534A 123-140 IPB000534B 324-336***** IPB000706 (N-acetyl-gamma-glutamyl-phosphate reductase, active site) with a combined E-value of 1.1e-06. IPB000706A 5-26 IPB000706E 123-140 IPB000706F 153-165 IPB000706I 317-350","Residues 117-310 are 98% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD002095) which is seen in DHAS_STRMU.Residues 8-345 are 19% similar to a (PROTEOME COMPLETE USG1 USG-1) protein domain (PD131454) which is seen in USG_HAEIN.Residues 316-341 are 96% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD331389) which is seen in Q9KA89_BACHD.Residues 122-339 are 28% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD415865) which is seen in DHAS_METTH.Residues 127-274 are 29% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD376765) which is seen in Q9KQG2_VIBCH.Residues 5-113 are 38% similar to a (DEHYDROGENASE PROTEOME COMPLETE) protein domain (PD274979) which is seen in Q9HPX0_HALN1.Residues 5-113 are 99% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD001262) which is seen in DHAS_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jan 28 15:11:37 2002","Tue Jan 8 14:01:53 2002","Mon Oct 14 18:17:10 2002","Tue Jan 8 13:57:46 2002","Tue Jan 8 13:57:46 2002","Tue Jan 8 13:57:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0899 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 13:58:02 2002","Tue Jan 8 13:57:46 2002","pdb|1BRM|C Chain C, Aspartate Beta-Semialdehyde Dehydrogenase F... 77 4e-015","SMU.989","","Residues 2 to 124 (E-value = 7.5e-57) place SMu0899 in the Semialdhyde_dh family which is described as Semialdehyde dehydrogenase, NAD binding domain (PF01118)Residues 137 to 328 (E-value = 1.1e-87) place SMu0899 in the Semialdhyde_dhC family which is described as Semialdehyde dehydrogenase, dimerisation domain (PF02774)","Tue Jan 8 13:57:46 2002","24379429","","Cardineau,G.A. and Curtiss,R. III.Nucleotide sequence of the asd gene of Streptococcus mutans.Identification of the promoter region and evidence forattenuator-like sequences preceding the structural geneJ. Biol. Chem. 262 (7), 3344-3353 (1987)PubMed: 2434499","Chen,N.Y., Jiang,S.Q., Klein,D.A. and Paulus,H.Organization and nucleotide sequence of the Bacillus subtilisdiaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthaseJ. Biol. Chem. 268 (13), 9448-9465 (1993)PubMed: 8098035Daniel,R.A. and Errington,J.Cloning, DNA sequence, functional analysis and transcriptionalregulation of the genes encoding dipicolinic acid synthetaserequired for sporulation in Bacillus subtilisJ. Mol. Biol. 232 (2), 468-483 (1993)PubMed: 8345520","Mon Jan 28 15:10:10 2002","Tue Jan 8 14:01:13 2002","1","","","SMU.989","363" "SMu0900","936827","937708","882","ATGTCAATTCAAGATTTTAAAGACGTCAACATTATTACAGCTTTCATCACCCCATTTAAAGAAGACGGATCAATCAATTTTGCTGCTCTTCCAAAGCTTATTGAGCATTTACTGGCTCATCATACTCAAGGTTTGCTCTTAGCGGGAACAACTGCTGAGAGTCCTACTCTTACTCATGATGAAGAATTGGAGTTGTTTGCTGCCGTTCAAAAAATTGTTAATGGACGTGTTCCTTTAATTGCTGGTGTGGGGACAAATGATACACGTGATTCTGTCAACTTTGTTAAAGAAGTTGCTGACTTTGGTGGTTTTTCTGCTGGTTTAGCTATTGTTCCTTATTACAACAAACCGACACAAGAAGGGCTCTATCAGCATTTTATGACTCTTGCTGATGCTAGTGATCTGCCTATTATTATTTATAATATTCCGGGACGCGTTGTGACAACATTAGAAACTGATACCATGCTTCGTTTGGCTCAGCATCCTAATATTATTGGTGTTAAAGAGTGTACAAATCTTGATAATATTGCTTATTTAGTTGACAATAAGCCAGATGATTTCTTAATCTTTACGGGTGAAGATGGCGAGGCTTTTCATGCTCTTAGTTTAGGGGCTGATGGCGTTATTAGTGTAGCTTCACATACTAATGGCGATGAGTTATTTGCTATGGTGGAGGCTATTGAAAAGAGTGATATTAAAAAGGCTGCTGGGATTCAGCGTCAATTTCTTCCTAAAGTTCACGCGCTCTTCTCTGTTGCCAGTCCAGCTCCTGTCAAAGCAGTTCTTAATCATCAAGGTTTTGATGCAGGGCCTTTGCGCTTGCCATTAGTTGCTTGTACTGATGAAGAAGCTAGACGCATTATTGAAATTGTTGAGAAATGA","4.70","-14.67","31771","MSIQDFKDVNIITAFITPFKEDGSINFAALPKLIEHLLAHHTQGLLLAGTTAESPTLTHDEELELFAAVQKIVNGRVPLIAGVGTNDTRDSVNFVKEVADFGGFSAGLAIVPYYNKPTQEGLYQHFMTLADASDLPIIIYNIPGRVVTTLETDTMLRLAQHPNIIGVKECTNLDNIAYLVDNKPDDFLIFTGEDGEAFHALSLGADGVISVASHTNGDELFAMVEAIEKSDIKKAAGIQRQFLPKVHALFSVASPAPVKAVLNHQGFDAGPLRLPLVACTDEEARRIIEIVEK","937707","For other 'dap' genes see SMu0821 (dapB) and SMu1763 (dapE).","dihydrodipicolinate synthase","Cytoplasm","Several matches in gapped BLAST to dihydrodipicolinate synthase: residues 1-291 are 77% similar to the enzyme in S.pneumoniae (gi|15900886|). Residues 2-289 are 66% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673602|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0039 (1e-17).","

InterPro
IPR002220
Family

Dihydrodipicolinate synthetase
PD001859	$\"[11-78]T$	DHDPS
PR00146	$\"[41-62]T$ $\"[77-95]T$ $\"[110-126]T$ $\"[135-152]T$	DHPICSNTHASE
PIRSF001365	$\"[7-293]T$	DHDPS
PTHR12128	$\"[1-293]T$	DHDPS
PF00701	$\"[7-283]T$	DHDPS
PS00666	$\"[140-170]T$	DHDPS_2

InterPro
IPR005263
Family

Dihydrodipicolinate synthase subfamily
TIGR00674	$\"[10-291]T$	dapA

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[11-292]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51569	$\"[11-293]T$	SSF51569

","BeTs to 13 clades of COG0329COG name: Dihydrodipicolinate synthetase/N-acetylneuraminate lyaseFunctional Class: E,MThe phylogenetic pattern of COG0329 is amtk-qvcEBrHuj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB002220 (Dihydrodipicolinate synthetase) with a combined E-value of 6.5e-49. IPB002220A 14-26 IPB002220B 41-62 IPB002220C 82-129 IPB002220D 136-147 IPB002220E 185-199 IPB002220F 204-217 IPB002220G 242-266","Residues 16-102 are 80% similar to a (SYNTHASE DIHYDRODIPICOLINATE LYASE BIOSYNTHESIS PROTEOME) protein domain (PD001859) which is seen in Q9CF61_LACLA.Residues 108-285 are 62% similar to a (SYNTHASE DIHYDRODIPICOLINATE LYASE BIOSYNTHESIS PROTEOME) protein domain (PD213669) which is seen in Q9CF61_LACLA.Residues 25-102 are 46% similar to a (HYDRATASE-ALDOLASE PYRUVATE PLASMID) protein domain (PD367468) which is seen in Q9KC32_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 14 18:18:03 2002","Tue Jan 8 14:05:13 2002","Mon Oct 14 18:18:03 2002","Tue Jan 8 14:05:13 2002","Tue Jan 8 14:05:13 2002","Tue Jan 8 14:05:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0900 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 14:08:19 2002","Tue Jan 8 14:05:13 2002","pdb|1DHP|A Chain A, Dihydrodipicolinate Synthase >gi|1942362|pd... 188 9e-049pdb|1F6P|A Chain A, Crystal Structure Analysis Of N-Acetylneura... 97 2e-021pdb|1FDZ|A Chain A, N-Acetylneuraminate Lyase In Complex With P... 90 2e-019","SMU.990","","Residues 7 to 292 (E-value = 3.9e-80) place SMu0900 in the DHDPS family which is described as Dihydrodipicolinate synthetase family (PF00701)","Tue Jan 8 14:05:13 2002","24379430","","","Chen,N.Y., Jiang,S.Q., Klein,D.A. and Paulus,H.Organization and nucleotide sequence of the Bacillus subtilisdiaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthaseJ. Biol. Chem. 268 (13), 9448-9465 (1993)PubMed: 8098035Richaud,F., Richaud,C., Ratet,P. and Patte,J.C.Chromosomal location and nucleotide sequence of the Escherichiacoli dapA geneJ. Bacteriol. 166 (1), 297-300 (1986)PubMed: 3514578Laber,B., Gomis-Ruth,F.X., Romao,M.J. and Huber,R.Escherichia coli dihydrodipicolinate synthase. Identification ofthe active site and crystallizationBiochem. J. 288 (Pt 2), 691-695 (1992)PubMed: 1463470","","Tue Jan 8 14:13:04 2002","1","","","SMU.990","994" "SMu0901","937986","938354","369","ATGTTAGTAACATTTAGAAAAGAGGTTCTTATGCAAGTTATCAAACGTAGTGGTCAAGTTGTTGATTTTGATCCTGATAAGATATATCAAGCTATTCTTGGTGCAGCACAAACAGTTTATGTATTAGATGATGCCTTGCGTCAAGATTTGGCACAAGTTACCAAAAAGGTTGTTGTTGATTTAGAAGAGGCACAGACTGAACGGCCCACAATTAGCATGATTCAATCACAAGTGGAACATCGTTTGCTTGATGCCGGTTATATCACAATTGCTGAGCATTATATTTCTTACCGCCTTCAACGTGATCTTGAGCGCAATGGTTACGATGATCATATTAATGTACACTTGCATTTTGAACAAGTTAAATAA","5.60","-3.80","14167","MLVTFRKEVLMQVIKRSGQVVDFDPDKIYQAILGAAQTVYVLDDALRQDLAQVTKKVVVDLEEAQTERPTISMIQSQVEHRLLDAGYITIAEHYISYRLQRDLERNGYDDHINVHLHFEQVK","938353","","conserved hypothetical protein (similar to ribonucleotide reductase alpha subunit)","Cytoplasm","Limited matches in gapped BLAST to hypothetical protein sequences: residues 11-122 are 80% similar to the protein from S.pneumoniae (gi|15902732|).Residues 6-122 are 74% similar to the protein from S.pyogenes (gi|15675175|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2086 (2e-14).","

InterPro
IPR005144
Domain

ATP-cone
PF03477	$\"[11-105]T$	ATP-cone
PS51161	$\"[11-105]T$	ATP_CONE

","BeTs to 4 clades of COG0209COG name: Ribonucleotide reductase alpha subunitFunctional Class: FThe phylogenetic pattern of COG0209 is a-tKYqvcEBRhujgp-linxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 13-110 are 40% similar to a (REDUCTASE RIBONUCLEOTIDE PROTEOME) protein domain (PD010634) which is seen in Q9ZAX6_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Aug 19 14:13:55 2002","Tue Oct 15 09:30:40 2002","Tue Oct 15 09:30:40 2002","Tue Jan 8 14:18:59 2002","","Tue Jan 8 14:18:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0901 is paralogously related (blast p-value < 1e-3) to SMu1882,a predicted anaerobic ribonucleoside-triphosphate reductase (Ribonucleotide reductase, class III, anaerobic).","Mon Jan 28 16:35:32 2002","","No significant hits to the NCBI PDB database.","SMU.991","","Residues 11 to 105 (E-value = 7.9e-24) place SMu0901 in the ATP-cone family which is described as ATP cone domain (PF03477)","Tue Jan 8 14:18:59 2002","24379431","","","","","","1","","","SMU.991","" "SMu0902","938639","939604","966","ATGTTAAAGGAAAACCGTAATAAAGGGTTTGTTTTATATCTTGTTTTTGGAATTTTCTTTATCATTGGAGCCGTAGGGATTTTTCTAGCAGTTTCTTATAAGAACAATAGTCAAGCAGTTTCTTATAACGGCGAGTCTACAAAGGCCTCTTCGGGAGACAAGGTGACGCTTGAAATTCGTGATATTTATTCCAAACCTATAGCAGATATTGATGGTCACAAGACAGTTATTTGGCTTGTGAAATATAAAGACAATGGTTATGTTGGTTTAGAATCTAAAGAAGAGGATAAGGATATTGCTAGATTATTAAAAGCTGGCAGTTCACTAAGACAGCATCCTAAACGCATTGCAGTGAAGTATTATAACACCCATAGAAGTACCAGCCATGTTATTCGAAATTATTCTGGTGCAATGATTGGTATTTTACGATCACAGCCTGAGTTGAACAAATATTTTTCATTTTATACTTATGTTTCTCTCTATGATATAAAATCTGATCAGACTAGCCTACCAATTGTATGTGGCCTCTTAGGTTTGCTTGGCTTGCTTTTTATAGGTATCGCTTTCTATGTTAGATATAAGGTTAATCGAGCTTATGATGAGCTTTATGCTGCTTATCCTGAATTAAATGGTAATTTAGACCCTCTCATCTCTGAATCGCTTTATCATGATGATAAGCTTAAAATTATTATTTATAAAAATCATCTTATAACTTATCATAGAGGATTTGCTCTTGTAGATCTGCATCAAGTTGTGCAACTTTACCATCGCATTGTTAAGACCAGACGTTCTTTTATTGCTGTCAATCAACAATCTTTTCTCGTTGCAGTCAAAATGGATAATAAGAAAGTTAGTCTATTTATTTGCAATCGTGGTAAGAAAACAGATGAAGAACTTCAGCCATTATTTGCTGCTGTTACAAGTTACTTCCCTAATATAAAAATTGGTTATGATAAATTATTTTAA","10.30","16.07","36734","MLKENRNKGFVLYLVFGIFFIIGAVGIFLAVSYKNNSQAVSYNGESTKASSGDKVTLEIRDIYSKPIADIDGHKTVIWLVKYKDNGYVGLESKEEDKDIARLLKAGSSLRQHPKRIAVKYYNTHRSTSHVIRNYSGAMIGILRSQPELNKYFSFYTYVSLYDIKSDQTSLPIVCGLLGLLGLLFIGIAFYVRYKVNRAYDELYAAYPELNGNLDPLISESLYHDDKLKIIIYKNHLITYHRGFALVDLHQVVQLYHRIVKTRRSFIAVNQQSFLVAVKMDNKKVSLFICNRGKKTDEELQPLFAAVTSYFPNIKIGYDKLF","939603","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu0902 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-26]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[169-191]?$	transmembrane_regions

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[122-230]T$	MMR_HSR1

InterPro
IPR005289
Domain

GTP-binding
TIGR00650	$\"[127-175]T$	MG442

InterPro
IPR006073
Domain

GTP1/OBG
PR00326	$\"[124-144]T$ $\"[170-185]T$	GTP1OBG

noIPR
unintegrated

unintegrated
G3DSA:1.10.1580.10	$\"[181-274]T$	G3DSA:1.10.1580.10
G3DSA:3.40.50.300	$\"[2-180]T$	G3DSA:3.40.50.300
PIRSF006230	$\"[4-278]T$	MG442
PTHR11089	$\"[32-275]T$	PTHR11089
PTHR11089:SF4	$\"[32-275]T$	PTHR11089:SF4
SSF52540	$\"[10-257]T$	SSF52540

","BeTs to 8 clades of COG1161COG name: Predicted GTPasesFunctional Class: RThe phylogenetic pattern of COG1161 is -m-kY-Vc-B----gpo----Number of proteins in this genome belonging to this COG is 2","***** IPB000765 (GTP1/OBG family) with a combined E-value of 4.6e-13. IPB000765 122-165","Residues 4-80 are 75% similar to a (COMPLETE PROTEOME GTP-BINDING ATP-BINDING) protein domain (PD009264) which is seen in Q9CG16_LACLA.Residues 177-276 are 60% similar to a (PROTEOME COMPLETE GTP-BINDING YLQF) protein domain (PD328815) which is seen in Q9CG16_LACLA.Residues 180-269 are 40% similar to a (MG442 ATP-BINDING PROTEOME K05_ORF271) protein domain (PD353947) which is seen in O31743_BACSU.Residues 126-176 are 78% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9CG16_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 2 14:32:57 2002","Tue Jan 8 14:29:53 2002","Tue Oct 15 09:31:34 2002","Tue Jan 8 14:23:11 2002","Tue Jan 8 14:23:11 2002","Tue Jan 8 14:23:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0903 is paralogously related (blast p-value < 1e-3) to SMu1744, a predicted phosphoglycerate dehydrogenase; SMu1130, a predicted thiophene degradation protein F; SMu1639,a predicted conserved hypothetical protein / possible GTP-binding protein; SMu1471 and SMu0862, both predicted GTP-binding proteins; and SMu0519, a predicted ferrous ion transport protein B.","Mon Jan 28 16:44:37 2002","","No significant hits to the NCBI PDB database.","SMU.993","","Residues 14 to 274 (E-value = 3.3e-72) place SMu0903 in the MMR_HSR1 family which is described as GTPase of unknown function (PF01926)","Tue Jan 8 14:23:11 2002","24379433","","","Kobayashi G, Moriya S, Wada C.Deficiency of essential GTP-binding protein ObgE in Escherichia coli inhibits chromosome partition.Mol Microbiol. 2001 Sep;41(5):1037-51.PMID: 11555285Ratnayake-Lecamwasam M, Serror P, Wong KW, Sonenshein AL.Bacillus subtilis CodY represses early-stationary-phase genes by sensing GTP levels.Genes Dev. 2001 May 1;15(9):1093-103.PMID: 11331605 ","Tue Apr 2 14:32:57 2002","Tue Jan 8 14:29:53 2002","1","","","SMU.993","359" "SMu0904","940639","941421","783","ATGGCAACGATTAAGGAAATTAAAGAACAGCTGGCGGCCATTTCTGACCTCTTAGATCCACATTGGACAGAGTTTGAGGCAGATGCCCGTTCAGGCGTTCAGGCAGCTGTTAGGCAGCGTAAAAAAATCATTCAAGCAGATTTAGACGAAGAGGTACGTTTGGAAAACATGCTGCGCTATGAAAAAGATCTGTATTTGCAAGGCTACCAAGCTATTGCAGGTATTGATGAAGTTGGCAGGGGTCCCTTAGCAGGTCCTGTTGTGGCAGCTTGTGTTATTCTGCCTAAAAACTGTAAAATCAGACATCTTAATGATTCTAAAAAAATTCCCAAAAAGAAGCATGAAGAGATTTACAAACAGGTCGTAAAAGTTGCCCTAGCTATTGGTATTGGTCGTATTTCTAGTGAAATGATTGATCAAGTCAACATTTATGAAGCAACTAAAATGGCTATGTTGCAGGCTATTGACGATTTGCAAGGTCTAGTTAGCCGACCGGATTATCTCTTAATTGATGCTATGAATCTTGGTATTTCAATTCCTCAGTCTTCCATTATCAAAGGAGATGCTCATTCGCTTTCGATAGCAGCAGCCTCTATTGTTGCTAAGGTAACGCGAGATAGGATGATGATTGGATATGACGAGATTTATCCTGGTTATGGTTTTGCTCAAAATGTAGGTTATGGTACTAAACAACACTTAGAAGGTTTAGAAACCTTGGGCGTAACTCCTATTCATCGAAGAACTTTTGAACCGATTAAGTCAATGTTAAAAGAAAAGAACTAA","7.60","1.36","28899","MATIKEIKEQLAAISDLLDPHWTEFEADARSGVQAAVRQRKKIIQADLDEEVRLENMLRYEKDLYLQGYQAIAGIDEVGRGPLAGPVVAACVILPKNCKIRHLNDSKKIPKKKHEEIYKQVVKVALAIGIGRISSEMIDQVNIYEATKMAMLQAIDDLQGLVSRPDYLLIDAMNLGISIPQSSIIKGDAHSLSIAAASIVAKVTRDRMMIGYDEIYPGYGFAQNVGYGTKQHLEGLETLGVTPIHRRTFEPIKSMLKEKN","941420","For other 'rnh' genes see SMu1703 (rnh3).From Genbank: [gi:13878721]This enzyme is an endonuclease that degrades the RNA of RNA-DNA hybrids specifically.","ribonuclease HII","Cytoplasm","Several matches in gapped BLAST to ribonuclease HII: residues 3-255 are 69% similar to the enzyme in S.pyogenes (gi|15675138|). Residues 1-259 are 65% similar to the protein from S.pneumoniae (gi|15903088|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1012 (3e-95).","

InterPro
IPR001352
Family

Ribonuclease HII/HIII
PTHR10954	$\"[60-252]T$	RNase_HII/HIII
PF01351	$\"[73-252]T$	RNase_HII

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[70-257]T$	RNaseH_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.10	$\"[71-214]T$	G3DSA:3.30.420.10

","BeTs to 15 clades of COG0164COG name: Ribonuclease HIIFunctional Class: LThe phylogenetic pattern of COG0164 is amtkyqvcebrhuj--o-inxNumber of proteins in this genome belonging to this COG is 1","***** IPB001352 (Ribonuclease HII) with a combined E-value of 2.4e-32. IPB001352A 74-88 IPB001352B 105-114 IPB001352C 186-206 IPB001352D 226-240","Residues 3-70 are 57% similar to a (HII MANGANESE NUCLEASE RIBONUCLEASE) protein domain (PD388586) which is seen in RNH2_LACLA.Residues 74-206 are 29% similar to a (RNASE RIBONUCLEASE SUBUNIT HI) protein domain (PD003015) which is seen in RNH2_METTH.Residues 72-249 are 61% similar to a (HII RIBONUCLEASE HYDROLASE RNASE) protein domain (PD005501) which is seen in RNH2_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 12:34:08 2002","Tue Jan 8 14:34:56 2002","Tue Oct 15 09:33:47 2002","Tue Jan 8 14:34:28 2002","Tue Jan 8 14:34:28 2002","Tue Jan 8 14:34:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0904 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 14:34:56 2002","","No significant hits to the NCBI PDB database.","SMU.994","","Residues 73 to 252 (E-value = 1.4e-63) place SMu0904 in the RNase_HII family which is described as Ribonuclease HII (PF01351)","Tue Jan 8 14:34:28 2002","24379434","","","Itaya,M., Omori,A., Kanaya,S., Crouch,R.J., Tanaka,T. and Kondo,K.Isolation of RNase H genes that are essential for growth ofBacillus subtilis 168J. Bacteriol. 181 (7), 2118-2123 (1999)PubMed: 10094689Ohtani,N., Haruki,M., Morikawa,M., Crouch,R.J., Itaya,M. andKanaya,S.Identification of the genes encoding Mn2+-dependent RNase HII andMg2+-dependent RNase HIII from Bacillus subtilis: classification of RNases H into three familiesBiochemistry 38 (2), 605-618 (1999)PubMed: 9888800","","Tue Jan 8 14:38:47 2002","1","","","SMU.994","559" "SMu0905","941595","942557","963","ATGAAAAAAGTACTCACTGTTCCAGTGCTGGGTGCAGCTGCAGTCTTTCTTTCTCTCGTTTCAATATTTATCGGTGTTAAGAGTCTATCGCTTTTTGAACTGGGCTCTTTAGACGATTCACAACTTAACATTTTATTATCTAGTCGCATTCCTAGAACGGTTAGTATTTTAATTGCTGGCTCTAGTTTAGCCGTTTGTGGTTTAATTATGCAGCAATTAACGCAAAATAAATTTGTCTCACCGACAACGGCTGGGACAATGGATTGGGCAAAGCTAGGTGTTGTTGTCACTATTATCTTATTTAGTAAATCTTCTTTACTATTGCAGTTGATTATTTCATCGGTCTTTGTCATTTTTGGTTCTTTGTTTTTTATCTATCTTTTAAAGGTTATTAAATTTAAGGATGATGTTTTCATTCCTCTAGTAGGTCTGATGTTGGGGAAAGTTGTATCTGCAATCAGTACTTTTTTAGGAGTACAGTTTCAGATATTGCAGTCTGTAAACAGTTGGTTAGAAGGTCATTTTTCCATCATGACTTCTCATCGATATGAGATTTTATTTTTGGTGCTGCCTTGCATGGTATTAATTTACCTTTATGCTCATCAGTTTACTATAGCTGGCTTGGGAGAAGATTTTTCTAAAAATCTAGGTTTGAATTATCAATTTATTATTAATTTAGGCTTGGTTCTTGTTTCGGTTATGACAGCTATCATTGTAACAGTTGTTGGCAGTCTTCCTTTTTTAGGTTTGATTGTTCCTAATTCGATTTCTGCTATCAAGGGCGATAATATGAAGAACAACTTAATATTAACCTCTTTTTTAGGTGCTGTTATTGTGCTTATTTGTGATATTTTTGGACGTCTTATTATTTTTCCATATGAAGTTTCTATTGGATTGACTATGGGAATAATAGGAAGTATCTTTTTCCTTTATTTTTTAATGAAGGGAAGAAGGCGTTCATGA","10.20","8.56","34980","MKKVLTVPVLGAAAVFLSLVSIFIGVKSLSLFELGSLDDSQLNILLSSRIPRTVSILIAGSSLAVCGLIMQQLTQNKFVSPTTAGTMDWAKLGVVVTIILFSKSSLLLQLIISSVFVIFGSLFFIYLLKVIKFKDDVFIPLVGLMLGKVVSAISTFLGVQFQILQSVNSWLEGHFSIMTSHRYEILFLVLPCMVLIYLYAHQFTIAGLGEDFSKNLGLNYQFIINLGLVLVSVMTAIIVTVVGSLPFLGLIVPNSISAIKGDNMKNNLILTSFLGAVIVLICDIFGRLIIFPYEVSIGLTMGIIGSIFFLYFLMKGRRRS","942556","For other components see SMu0907 (NBD1); SMu0906 (MSD2) and SMu0908 (SBP1).","ferrichrome ABC transporter (permease)","Membrane, Cytoplasm","Limited matches in gapped BLAST to ferrichrome ABC transporter (permease): residues 15-315 are 49% similar to the enzyme in B.subtilis (gi|16077448|).Residues 1-315 are 48% similar to the enzyme in B.halodurans (gi|10173640|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1010 (1e-116).","

InterPro
IPR000522
Family

Bacterial transport system permease protein
PF01032	$\"[13-315]T$	FecCD

noIPR
unintegrated

unintegrated
SSF81345	$\"[2-316]T$	SSF81345

","BeTs to 8 clades of COG0609COG name: Iron, hemin, cobalamine permeasesFunctional Class: P,HThe phylogenetic pattern of COG0609 is AM-K--VCEB-Huj-------Number of proteins in this genome belonging to this COG is 2","***** IPB000522 (FecCD transport family) with a combined E-value of 8.4e-33. IPB000522A 49-90 IPB000522B 243-257 IPB000522C 292-315 IPB000522C 107-130","Residues 208-315 are 55% similar to a (PERMEASE TRANSPORT PROTEOME COMPLETE) protein domain (PD001557) which is seen in Q9KE33_BACHD.Residues 2-81 are 51% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME) protein domain (PD001584) which is seen in Q9PMU7_CAMJE.Residues 83-204 are 41% similar to a (PROTEOME COMPLETE PERMEASE TRANSPORT) protein domain (PD173656) which is seen in P94418_BACSU.Residues 188-319 are 20% similar to a (TRANSPORT SYSTEM FERRIC MEMBRANE) protein domain (PD198734) which is seen in FEPG_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 10:08:49 2002","Mon Jan 28 16:46:09 2002","Tue Oct 15 09:35:43 2002","Tue Jan 8 15:25:28 2002","Tue Jan 8 15:25:28 2002","Tue Jan 8 15:25:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0905 is paralogously related (blast p-value < 1e-3) to SMu0906, and SMu0165, both ABC transporter permeases.","Mon Jan 28 16:46:09 2002","","No significant hits to the NCBI PDB database.","SMU.995","","Residues 25 to 315 (E-value = 1.3e-42) place SMu0905 in the FecCD family which is described as FecCD transport family (PF01032)","Tue Jan 8 15:25:28 2002","24379435","","","Koster,W.L., Actis,L.A., Waldbeser,L.S., Tolmasky,M.E. andCrosa,J.H.Molecular characterization of the iron transport system mediated by the pJM1 plasmid in Vibrio anguillarum 775J. Biol. Chem. 266 (35), 23829-23833 (1991)PubMed: 1748657","","Tue Jan 8 15:29:35 2002","1","","","SMU.995","804" "SMu0906","942554","943525","972","ATGATATTAACTTTCAAACAAAAATTATGGTTAATCTTAGTTCTAGTTATTACTTTATCAGCTCTTTACCTACTTTATGGCATCGGTCCAGATGTTAATAAATTTTTAATAATCTATATGGTCAATTCACGTTATAAGCGGTTATTAGCAATTTTACTGACGGCTGTATGTGTTGGTGCTTCGACGCTTATTTTTCAAACGATTAGTAACAATCGTATCTTAACACCAAGTATTATTGGTTTAGATAGTGTTTACGTCTTTATTCAGACAATCATGCTGTTTTTCTTGGGAAGTCAGCAGACTCTTAAAATATCAGCATTGTCAAATTATTGCTTATCGTTATTGATTATGGTGGGCTTTGCATTTTTCCTGTTTAAGGTCCTATTTAAACAGCAGGAGTATTCTATTTATTTTGTACTTCTTTGTGGTTTAGTTTTAAATACCCTTTTTAGTTCTTTGTCATCTTTTTTTCAGATGCTCATTGATCCCAATGATTTTTTGATTTTGCAAACCAATTTGTTTGCTAGTTTTAATGCCATTAATACAAAATTATTGTGGGTATCCCTTATTATAGTCGTTTTTGTGCTTTTAATTAGTTGGACTTCCTTGAGGAAATTGGATGTACTTTTGTTGGGAAAAGATGTGGCGATTAGTTTGGGCTTGGATTATGATCTTCTGGTCATGAAATTTTTTATCTTAGTATCTATTTTGATTTCAGTTTCGACAGCACTTGTCGGTCCAATTACCTTTCTTGGCCTTTTAGTGGTTAATCTCGCCTATCATATTTTTCCAACTTATCGGCATAGTATTTTGCTACCAGCTAGCATTCTGATTGGCATGTTAGCACTTGTCGGTGGTCAAATTATTGTTCAATATGTCCTGACTTTAGAAACGCAACTGAGCGTTATTTTAAACTTTATTGGAGGAATTTACTTTATCCTCATTTTACTGAAAGAGAGTAAAGATAAATGA","10.00","7.32","36258","MILTFKQKLWLILVLVITLSALYLLYGIGPDVNKFLIIYMVNSRYKRLLAILLTAVCVGASTLIFQTISNNRILTPSIIGLDSVYVFIQTIMLFFLGSQQTLKISALSNYCLSLLIMVGFAFFLFKVLFKQQEYSIYFVLLCGLVLNTLFSSLSSFFQMLIDPNDFLILQTNLFASFNAINTKLLWVSLIIVVFVLLISWTSLRKLDVLLLGKDVAISLGLDYDLLVMKFFILVSILISVSTALVGPITFLGLLVVNLAYHIFPTYRHSILLPASILIGMLALVGGQIIVQYVLTLETQLSVILNFIGGIYFILILLKESKDK","943524","For other components see SMu0907 (NBD1); SMu0905 (MSD1) and SMu0908 (SBP1). ","ABC transporter, permease protein;possible ferrichrome transport system","Membrane, Cytoplasm","Limited matches in gapped BLAST to ferrichrome ABC transporter (permease): residues 6-321 are 42% similar to the enzyme in B.subtilis (gi|16077449|).Residues 5-321 are 41% similar to the enzyme in B.halodurans (gi|15613589|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1009 (9e-86).","

InterPro
IPR000522
Family

Bacterial transport system permease protein
PF01032	$\"[3-318]T$	FecCD

noIPR
unintegrated

unintegrated
SSF81345	$\"[1-319]T$	SSF81345

","BeTs to 8 clades of COG0609COG name: Iron, hemin, cobalamine permeasesFunctional Class: P,HThe phylogenetic pattern of COG0609 is AM-K--VCEB-Huj-------Number of proteins in this genome belonging to this COG is 2","***** IPB000522 (FecCD transport family) with a combined E-value of 5.1e-27. IPB000522A 44-85 IPB000522B 246-260 IPB000522C 295-318 IPB000522C 233-256","Residues 206-321 are 47% similar to a (PERMEASE TRANSPORT PROTEOME COMPLETE) protein domain (PD001557) which is seen in Q9KE32_BACHD.Residues 6-78 are 42% similar to a (COMPLETE PROTEOME TRANSPORT PERMEASE) protein domain (PD343354) which is seen in P94419_BACSU.Residues 79-182 are 41% similar to a (COMPLETE PROTEOME PERMEASE TRANSPORT) protein domain (PD100222) which is seen in P94419_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 10:34:53 2002","Mon Jan 28 16:50:57 2002","Tue Oct 15 09:36:12 2002","Tue Jan 8 15:31:09 2002","Tue Jan 8 15:31:09 2002","Tue Jan 8 15:31:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0906 is paralogously related (blast p-value < 1e-3) to SMu0905, and SMu1960, both predicted ABC transporter permeases.","Mon Jan 28 16:50:57 2002","","No significant hits to the NCBI PDB database.","SMU.996","","Residues 14 to 318 (E-value = 1.6e-33) place SMu0906 in the FecCD family which is described as FecCD transport family (PF01032)","Tue Jan 8 15:31:09 2002","24379436","","","Koster,W.L., Actis,L.A., Waldbeser,L.S., Tolmasky,M.E. and Crosa,J.H. Molecular characterization of the iron transport system mediated bythe pJM1 plasmid in Vibrio anguillarum 775 J. Biol. Chem. 266 (35), 23829-23833 (1991) PubMed: 1748657 ","","Tue Jan 8 15:33:52 2002","1","","","SMU.996","803" "SMu0907","943522","944328","807","ATGATTTCTGTTAAAAATATTATCAAACATTATCAACGAAAGCCCGTTCTTAACGATTTAACTGTGAATATTGAAAAAGGAAAAATCACAGCTATCATCGGATCAAATGGTTCAGGGAAAAGTACATTTTTATCTATTATGAGCCGTTTGATTGAAGGAGATAGTGGACAAGTCCTATTAGACAAAAAAGCATTAAAATCATTTAATAATAATGATTTGGCCAAAAGGCTGGCTATTTTAAGGCAAACAAACTATATTAATCTTAAAATTAGGGTAGCAGAATTGGTTGCTTTTGGAAGGTTCCCTCATCATCAAGGAAGATTGACCCAAAACGATCAAGATAAAATAACACAAGCGCTTGCTTATATGGAACTTGAGGAGATCAAAGATCGCTTTCTTGATGAATTAAGTGGCGGTCAATTACAACGAGCCTTTATTGCTATGATACTAGCTCAGGATACAGACTATATTTTACTAGATGAACCTTTAAATAATCTGGATATGAAACACTCTGTTCAGATTATGCAGATACTAAGGCGTTTGGTAAAAGATTTTAATAAAACGATTATACTTGTGATTCACGATATTAACTTTGCTTCTTGCTATGCTGACAATATTGTTGCTTTAAAAGAAGGAAAAATTATTGCCAATGGAAATGTGGATGAAGTGGTCAAAGAAGAAGTCTTGTCTAAAATCTACGATATGCCAATAAAAATTGAAACTTATCAAGGAAGAAAGATTTGTAACTATTTTGACCCTCAGGAGCAAATACATTGCGAAACAGCACATAAATTATTAAGCAAATAG","8.70","4.55","30554","MISVKNIIKHYQRKPVLNDLTVNIEKGKITAIIGSNGSGKSTFLSIMSRLIEGDSGQVLLDKKALKSFNNNDLAKRLAILRQTNYINLKIRVAELVAFGRFPHHQGRLTQNDQDKITQALAYMELEEIKDRFLDELSGGQLQRAFIAMILAQDTDYILLDEPLNNLDMKHSVQIMQILRRLVKDFNKTIILVIHDINFASCYADNIVALKEGKIIANGNVDEVVKEEVLSKIYDMPIKIETYQGRKICNYFDPQEQIHCETAHKLLSK","944327","For other components see SMu0905 (MSD1); SMu0906 (MSD2) and SMu0908 (SBP1). ","inorganic ion ABC transporter,ATP-binding protein; possible ferrichrome transport system","Cytoplasm, Membrane","Matches in gapped BLAST to a previously published protein from S.mutans:residues 1-233 are 30% similar to SloA (gi|8925937|).Limited matches in gapped BLAST to ferrichrome ABC transporter(permease): residues 1-251 are 56% similar to the enzyme inB.subtilis (gi|16077450|).Residues 2-250 are 50% similar to the protein in S.pneumoniae (gi|15903728|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1008 (2e-82).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[135-178]T$	ABC_transporter
PF00005	$\"[27-212]T$	ABC_tran
PS00211	$\"[136-150]T$	ABC_TRANSPORTER_1
PS50893	$\"[2-236]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-213]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-234]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-243]T$	PTHR19222
PTHR19222:SF31	$\"[2-243]T$	PTHR19222:SF31
SSF52540	$\"[1-227]T$	SSF52540

","BeTs to 8 clades of COG1120COG name: ABC-type iron (III) transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1120 is AM-K--VcEB-Hujgp-----Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.4e-25. IPB001140A 16-62 IPB001140B 133-171 IPB001140C 189-218","Residues 5-221 are 22% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 139-186 are 75% similar to a (GENES ORFA ORFB CEUB) protein domain (PD055560) which is seen in Q46005_CAMCO.Residues 22-228 are 25% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 73-130 are 58% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD001985) which is seen in Q9PMU5_CAMJE.Residues 27-214 are 30% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 1-127 are 27% similar to a (PROTEOME ATP-BINDING SYSTEM COMPLETE) protein domain (PD295227) which is seen in Q9PMD1_CAMJE.Residues 181-218 are 65% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9PMU5_CAMJE.Residues 17-68 are 50% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9PMU5_CAMJE.Residues 135-178 are 84% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9KE31_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 10:17:56 2002","Tue Jan 8 15:35:26 2002","Tue Oct 15 09:37:16 2002","Tue Jan 8 15:35:26 2002","Tue Jan 8 15:35:26 2002","Tue Jan 8 15:35:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0907 is paralogously related (blast p-value < 1e-3) to SMu0164, SMu1950, SMu0418, SMu0884, SMu0517, SMu1920, SMu0971, SMu1949, SMu1288, SMu0849, SMu1811, SMu1518, SMu1003, SMu0235, SMu1380, SMu0950, SMu0731, SMu0786, SMu1762, SMu0218, SMu1064, SMu0390, SMu1757, SMu1751, SMu1410, SMu1210, SMu1246, SMu1231, SMu0916, SMu1517, SMu1068, SMu0824, SMu1545, SMu0234, SMu0805, SMu0335, SMu1001, SMu0986, SMu0596, SMu1959, SMu1093, SMu1079, SMu0258, SMu1428, SMu1065, SMu1037, SMu0976, SMu0944, SMu1023, SMu0823, SMu0836, SMu0752, SMu1710, SMu0476, SMu0475, SMu1649, SMu0216, SMu1036, SMu1316, SMu0825, SMu0594, SMu0837, SMu0374, SMu0666, SMu0987, SMu1050, SMu0224, SMu1306, SMu0729, SMu1724, SMu0024, SMu1686, and SMu1202, all ABC-related ATP-binding proteins.","Thu Mar 21 09:24:42 2002","Tue Jan 8 15:35:26 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 92 5e-020pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 80 2e-016","SMU.997","","Residues 27 to 212 (E-value = 6.6e-48) place SMu0907 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jan 8 15:35:26 2002","24379437","","","Koster,W.L., Actis,L.A., Waldbeser,L.S., Tolmasky,M.E. and Crosa,J.H. Molecular characterization of the iron transport system mediated bythe pJM1 plasmid in Vibrio anguillarum 775 J. Biol. Chem. 266 (35), 23829-23833 (1991) PubMed: 1748657 ","","Tue Jan 8 15:40:22 2002","1","","","SMU.997","677" "SMu0908","944370","945392","1023","ATGAAAATGAAACCATTTAAAAACTTATTTGCAGCATTTTTACTTGTTATTTTTGCTTTTACTTTTACATCTAAAGCCTTTGCGGCGGATAAAACTGTAAAAGTGGAAAATAATTATGCCATTAAATCAGAAGATAAAAAATCAAATCCAAAAATGGTCAATGAGACGGTTACTGTCAAAAAGAACCCTCAAAAGGTTGTCGTTTACGACTTAGGAGCCTTGGATACTATCACCGCCTTAGGCAAAGAAAAAAATGTTGTTGCTATCCCAAAATCTCAACATGGCCTTAATATGTTGAATAAAGATATGAAAAAAATTTATTCAGCTAAGAAATATCAAAATGCAGGTTCACTTTTTGAACCTGACTTTGAAACAATTGCAAAACTGCAACCAGACTTAATTATTATCAGCGGGCGTTCCGCGACATCTAAAAACATCGAAGAGCTGAAAAAAGCTGCTCCAAAGGCTGCTATTGTTTACGGTTCAGCATCTATGGATGCTAATCTTATGACTGGTGTTAAAGAAAAAGCAATAACCTTTGGTAAAATTTTCGGTAAGGAAAAGAAGGCTAAAGCATATAATAAAGAGCTTGATCAGTCTCTTAAAAAATTGAAAACAAAAGTGAATCATTTAAAAAATCCGTCAGCATTATTCGTTATCGCTAACAGTGGTGAATTGTTAAGTCAATCGCCTAAAGGACGTTTTGGCTGGATTTTTAAGGAATTGGGATTTAAAGCTGTTAATGAAGGAGATAAAGTAAGCACCCATGGCTCGCCAGTTTCTTACGAGTATATTTCAGAAAAGAACCCTCAGTATCTCTTTGTTTTAGATAGAGGAGCAACAATTGGTCAGGATGCTTCTGCAGATAAGATTTTGCAGAATGATGTGATTAAGGATACGAATGCTATTAAAAACAATCATGTCCTTCAAGTTAATGGTAAAAATTGGTACCTTAATACAGGTGGTATTAGAACAACCAAAGCAATGATTAAAGAAGTTCAATCATTTATTGATAAAAAATAA","10.60","23.97","37671","MKMKPFKNLFAAFLLVIFAFTFTSKAFAADKTVKVENNYAIKSEDKKSNPKMVNETVTVKKNPQKVVVYDLGALDTITALGKEKNVVAIPKSQHGLNMLNKDMKKIYSAKKYQNAGSLFEPDFETIAKLQPDLIIISGRSATSKNIEELKKAAPKAAIVYGSASMDANLMTGVKEKAITFGKIFGKEKKAKAYNKELDQSLKKLKTKVNHLKNPSALFVIANSGELLSQSPKGRFGWIFKELGFKAVNEGDKVSTHGSPVSYEYISEKNPQYLFVLDRGATIGQDASADKILQNDVIKDTNAIKNNHVLQVNGKNWYLNTGGIRTTKAMIKEVQSFIDKK","945391","For other components see SMu0907 (NBD1); SMu0905 (MSD1) and SMu0906 (MSD2).For other 'fat' genes see SMu1292 (FatB2).","ABC transporter, ferrichrome-binding protein","Membrane, Periplasm","Limited matches in gapped BLAST to ferrichrome ABC transporter(binding protein): residues 59-339 are 41% similar to the enzyme in B.subtilis (gi16077451).Residues 37-334 are 36% similar to the protein in S.pneumoniae (gi15901700).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1007 (1e-100).","

InterPro
IPR002491
Family

Periplasmic binding protein
PF01497	$\"[63-315]T$	Peripla_BP_2
PS50983	$\"[65-340]T$	FE_B12_PBP

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1980	$\"[62-198]T$	G3DSA:3.40.50.1980
SSF53807	$\"[60-337]T$	SSF53807

","BeTs to 8 clades of COG0614COG name: Ferrichrome-binding periplasmic proteinsFunctional Class: PThe phylogenetic pattern of COG0614 is aM-K--VCEBRhUJ-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 59-203 are 30% similar to a (COMPLETE PROTEOME FERRICHROME ABC) protein domain (PD121624) which is seen in O07616_BACSU.Residues 33-207 are 44% similar to a (LIPOPROTEIN PROTEOME COMPLETE TRANSPORT) protein domain (PD121590) which is seen in O87828_STAAU.Residues 63-208 are 30% similar to a (PROTEOME COMPLETE TRANSPORT PERIPLASMIC) protein domain (PD344325) which is seen in O34348_BACSU.Residues 224-333 are 39% similar to a (PROTEOME COMPLETE TRANSPORTER ABC) protein domain (PD121594) which is seen in Q9JWB9_NEIMA.Residues 65-206 are 35% similar to a (PERIPLASMIC TRANSPORT FHUD LIPOPROTEIN) protein domain (PD128372) which is seen in Q9JXL2_NEIMB.Residues 65-209 are 40% similar to a (PROTEOME COMPLETE FERRIC PERIPLASMIC) protein domain (PD349516) which is seen in P94421_BACSU.Residues 65-308 are 27% similar to a (PROTEOME COMPLETE PERIPLASMIC UPTAKE) protein domain (PD415990) which is seen in Q9PM58_CAMJE.Residues 62-202 are 24% similar to a (SIGNAL HEMIN RECEPTOR PRECURSOR) protein domain (PD284489) which is seen in Q9RZU7_DEIRA.Residues 217-316 are 44% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD002027) which is seen in P94421_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 10:10:11 2006","Thu Sep 14 10:10:11 2006","Thu Sep 14 10:10:11 2006","Tue Jan 8 15:41:37 2002","","Tue Jan 8 15:41:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0908 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 15:42:53 2002","","No significant hits to the NCBI PDB database.","SMU.998","","Residues 63 to 315 (E-value = 2e-37) place SMu0908 in the Peripla_BP_2 family which is described as Periplasmic binding protein (PF01497)","Tue Jan 8 15:41:37 2002","24379438","","","Koster,W.L., Actis,L.A., Waldbeser,L.S., Tolmasky,M.E. and Crosa,J.H. Molecular characterization of the iron transport system mediated bythe pJM1 plasmid in Vibrio anguillarum 775 J. Biol. Chem. 266 (35), 23829-23833 (1991) PubMed: 1748657 ","","Tue Jan 8 15:43:35 2002","1","","","SMU.998","931" "SMu0909","945464","945745","282","ATGGTTAATATGTTATCGAGAAAAATTGCTAATAAAGCAGTAGAATCTTTGAATAAGACAAAACATCGAGATCTTTATTATATTCTAATCAGTTTTGGTTTAGGTTTACTGTTTACTTTGGTCGGAATTTATAACATTTTTACAGAGGCTACTAAAGACGTTACTACACGAATCATTGGTGTTATTTTATGCTTGGCATTAGGGATATTGTTTTTATTTTTGGGAGTCGCTCTGCTTAGAATTAAATTTAAACAAAATGAATCAGAAGATGGAAATAAATAG","10.40","5.17","10448","MVNMLSRKIANKAVESLNKTKHRDLYYILISFGLGLLFTLVGIYNIFTEATKDVTTRIIGVILCLALGILFLFLGVALLRIKFKQNESEDGNK","945744","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu0909 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-39]?$	signal-peptide
tmhmm	$\"[28-48]?$ $\"[58-78]?$	transmembrane_regions

InterPro
IPR003488
Family

SMF protein
PF02481	$\"[61-269]T$	SMF
TIGR00732	$\"[60-278]T$	dprA

noIPR
unintegrated

unintegrated
SSF102405	$\"[104-278]T$	SSF102405

","BeTs to 9 clades of COG0758COG name: Protein involved in DNA uptakeFunctional Class: NThe phylogenetic pattern of COG0758 is -----qvcebrhuj--ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 72-219 are 47% similar to a (COMPLETE PROTEOME DNA PROCESSING) protein domain (PD007421) which is seen in Q9WY92_THEMA.Residues 221-270 are 48% similar to a (PA0021 PROTEOME RV2896C COMPLETE) protein domain (PD033916) which is seen in Q9I7A6_PSEAE.Residues 221-277 are 54% similar to a (COMPLETE PROTEOME DNA PROCESSING) protein domain (PD394610) which is seen in Q9KA22_BACHD.Residues 221-280 are 48% similar to a (COMPLETE PROTEOME A CHAIN) protein domain (PD295569) which is seen in SMF_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 08:29:28 2002","Tue Sep 12 14:11:04 2006","Tue Sep 12 14:11:04 2006","Wed Jan 9 08:28:50 2002","","Wed Jan 9 08:28:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0911 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 08:29:28 2002","","No significant hits to the NCBI PDB database.","SMU.1001","","Residues 61 to 269 (E-value = 1.6e-89) place SMu0911 in the SMF family which is described as SMF family (PF02481)","Wed Jan 9 08:28:50 2002","24379441","","","Meinnel,T., Guillon,J.M., Mechulam,Y. and Blanquet,S.The Escherichia coli fmt gene, encoding methionyl-tRNA(fMet)formyltransferase, escapes metabolic controlJ. Bacteriol. 175 (4), 993-1000 (1993)PubMed: 8432722Mazel,D., Pochet,S. and Marliere,P.Genetic characterization of polypeptide deformylase, a distinctiveenzyme of eubacterial translationEMBO J. 13 (4), 914-923 (1994)PubMed: 8112305","","Wed Jan 9 08:32:38 2002","1","","","SMU.1001","358" "SMu0912","946849","948966","2118","TTGACAAGTAAAACAACGACAACAGTAAAAAAGACGAGTAAAAAGCGAGCGACTCCTAAGAAAAATTTAGTCATTGTCGAGTCACCTGCTAAGGCGAAAACCATTGAGAAATATCTAGGACGTTCATATAAAGTGGTGGCTTCTGTAGGGCATATTCGTGACTTAAAAAAGTCAAGCATGTCCATTGATTTTGATAATAATTATGAGCCGCAATATATTAATATTCGCGGCAAGGGTCCCTTAATCAATTCTCTAAAAAAAGAAGCTAAGAATGCCAAGCAAATCTTTTTAGCAAGTGACCCGGATCGTGAAGGGGAAGCGATTTCTTGGCATTTAGCTCATATTTTGGATTTAGATCTTAAAGGTAAAAACCGTGTTGTCTTTAATGAAATCACTAAAGATGCTGTCAAAAATGCCTTTGTCGAGCCGCGTCAAATTGACATGGATCTTGTTGATGCCCAACAAGCCCGTCGTGTTTTGGATAGAATTGTTGGTTATTCTATTTCTCCTATTCTTTGGAAAAAAGTTAAGAAAGGTCTTTCAGCTGGTCGTGTACAGTCTGTTGCTCTTAAACTTATTATTGACCGCGAAAATGAAATCAAAGCTTTTAAACCAGAGGAGTATTGGAGTATTGATGGTTTCTTTAAAAAAGGAAATAAGAAATTCCAAGCTAATTTTTATGGACTTGATAACAAAAAAACTAAGCTGAAAAGCAATGATGATGTTAAGAAAGTATTGACTCGCATTAAGAATGATGACTTTCTTGTTGACAAAGTAGAAAAGAAAGAACGAAAACGTAATGCACCGCTTCCTTATACGACATCTTCCTTGCAACAAGATGCCGCCAATAAGATTAATTTCAGAACACGAAAAACCATGATGGTTGCTCAGCAGCTTTATGAAGGAATAAGACTTGGCTCTAATGGCCAGCAAGGTCTAATTACCTATATGCGTACAGATTCAACTAGAATCAGCCCTGTGGCTCAAAATGATGCTGCTAATTATATTACTGAACATTTTGGTGCTGAATATTCTAAACACGGAAATCATGTTCGCAATGCCTCCGGTGCTCAAGATGCCCATGAAGCGATTCGTCCATCTAATGTTAATCATACACCTGAATCCATTGCTAAATATCTTGATAAAGATCAATTAAAACTTTATACTCTCATTTGGAATCGTTTTGTTGCTAGTCAGATGACCGCCGCAGTTTTTGATACTGTTAAGGTTAATTTGACGCAAAACGGTGTCTTATTTATCGCTAACGGCAGTCAGATTAAGTTCAAGGGCTATATGGCTGTTTACAACGATTCTGATAAGACCAAAGTACTTCCTGAAATGATCAAGGGAGAAACAGTTAAAAAGATTTCAGCTAATCCTGAGCAGCATTTCACGCAACCACCTGCTCGTTATTCAGAAGCAAGTCTTATTAAGACTTTGGAAGAAAATGGTGTTGGTCGTCCATCAACCTATGCACCGACTCTTGAGACGATCCAAAAGCGTTACTATGTACGTTTAGTATCTAAGCGTTTTGAGCCTACAGAACTTGGTGAAATTGTTAATTCTTTAATTATAGAATTTTTCCCCGACATTGTTGATGTGAAATTCACTGCTGAAATGGAAAGTAAACTGGACGAAGTTGAGATTGGCAAAGAGGAGTGGCAGAAGGTTATTGACCAATTTTATAAACCATTTGAAAAAGAGGTTATTAAAGCAGAGGAACAGATGGAAAAAATCCAAATTAAGGATGAACCTGCCGGTTTTGACTGTGATGTTTGTGGGCATCCAATGGTTATTAAATTAGGTCGCTATGGTAAATTTTACGCTTGCAGTAATTTTCCAGATTGCCATAATACCAAAGCTATTACTAAAGAAATTGGAGTGATATGTCCGATTTGTCAAAAAGGTCAAGTCATTGAGCGAAAAACAAAGCGTAATCGTATTTTCTATGGCTGTGATCGCTATCCTGATTGTGATTTTACTTCATGGAATAAACCTATAGGCCGCGATTGTCCAAAATCTGGAGATTTTCTCGTTGAGAAAAAAATCCGTGGCGGCGGCAAACAAGTTGTTTGTAGCAATGAGGAGTGTGACTATAAGGAAAAAGCTGTTAAATAA","10.10","31.19","80243","MTSKTTTTVKKTSKKRATPKKNLVIVESPAKAKTIEKYLGRSYKVVASVGHIRDLKKSSMSIDFDNNYEPQYINIRGKGPLINSLKKEAKNAKQIFLASDPDREGEAISWHLAHILDLDLKGKNRVVFNEITKDAVKNAFVEPRQIDMDLVDAQQARRVLDRIVGYSISPILWKKVKKGLSAGRVQSVALKLIIDRENEIKAFKPEEYWSIDGFFKKGNKKFQANFYGLDNKKTKLKSNDDVKKVLTRIKNDDFLVDKVEKKERKRNAPLPYTTSSLQQDAANKINFRTRKTMMVAQQLYEGIRLGSNGQQGLITYMRTDSTRISPVAQNDAANYITEHFGAEYSKHGNHVRNASGAQDAHEAIRPSNVNHTPESIAKYLDKDQLKLYTLIWNRFVASQMTAAVFDTVKVNLTQNGVLFIANGSQIKFKGYMAVYNDSDKTKVLPEMIKGETVKKISANPEQHFTQPPARYSEASLIKTLEENGVGRPSTYAPTLETIQKRYYVRLVSKRFEPTELGEIVNSLIIEFFPDIVDVKFTAEMESKLDEVEIGKEEWQKVIDQFYKPFEKEVIKAEEQMEKIQIKDEPAGFDCDVCGHPMVIKLGRYGKFYACSNFPDCHNTKAITKEIGVICPICQKGQVIERKTKRNRIFYGCDRYPDCDFTSWNKPIGRDCPKSGDFLVEKKIRGGGKQVVCSNEECDYKEKAVK","948965","For DNA topoisomerase IV subunit C see SMu1100.For DNA topoisomerase IV subunit B see SMu1106.From Genbank:[gi:14423965]The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. ","DNA topoisomerase I","Cytoplasm, Periplasm","Several matches in gapped BLAST to DNA topoisomerase I: residues 22-705 are 84% similar to the enzyme in S.pyogenes (gi|15675140|) and are 81% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673212|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1005 (0.0).","

InterPro
IPR000380
Family

DNA topoisomerase, type IA
PR00417	$\"[95-108]T$ $\"[180-198]T$ $\"[311-320]T$ $\"[387-403]T$ $\"[484-498]T$	PRTPISMRASEI
PTHR11390	$\"[30-622]T$	PROKARYOTIC DNA TOPOISOMERASE
PS00396	$\"[297-320]?$	TOPOISOMERASE_I_PROK

InterPro
IPR003601
Domain

DNA topoisomerase, type IA, domain 2
SM00436	$\"[122-210]T$	TOP1Bc

InterPro
IPR003602
Domain

DNA topoisomerase, type IA, DNA-binding
SM00437	$\"[260-521]T$	TOP1Ac

InterPro
IPR005733
Domain

DNA topoisomerase I, bacterial-type
TIGR01051	$\"[23-623]T$	topA_bact: DNA topoisomerase I

InterPro
IPR006154
Domain

Toprim subdomain
SM00493	$\"[21-121]T$	TOPRIM

InterPro
IPR006171
Domain

TOPRIM
PF01751	$\"[21-130]T$	Toprim

InterPro
IPR013497
Domain

DNA topoisomerase, type IA, central
PF01131	$\"[143-547]T$	Topoisom_bac

InterPro
IPR013498
Domain

DNA topoisomerase, type IA, zn finger
PF01396	$\"[587-625]T$ $\"[627-667]T$ $\"[668-704]T$	zf-C4_Topoisom

InterPro
IPR013824
Domain

DNA topoisomerase, type IA, central region, subdomain 1
G3DSA:1.10.460.10	$\"[153-218]T$ $\"[457-586]T$	no description

InterPro
IPR013826
Domain

DNA topoisomerase, type IA, central region, subdomain 3
G3DSA:1.10.290.10	$\"[268-401]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.140	$\"[19-152]T$	no description

","BeTs to 17 clades of COG0550COG name: Topoisomerase IAFunctional Class: LThe phylogenetic pattern of COG0550 is amtkyqvcEBrHUJgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000380 (Prokaryotic DNA topoisomerase I) with a combined E-value of 2e-170. IPB000380A 23-35 IPB000380B 38-55 IPB000380C 95-112 IPB000380D 125-136 IPB000380E 151-174 IPB000380F 180-211 IPB000380G 271-301 IPB000380H 312-328 IPB000380I 353-367 IPB000380J 386-403 IPB000380K 465-504 IPB000380L 528-546","Residues 323-380 are 74% similar to a (TOPOISOMERASE ENZYME DNA DNA-BINDING) protein domain (PD114071) which is seen in Q9CG80_LACLA.Residues 597-662 are 83% similar to a (TOPOISOMERASE DNA ENZYME COMPLETE PROTEOME DNA-BINDING) protein domain (PD003328) which is seen in Q9CG80_LACLA.Residues 92-138 are 85% similar to a (TOPOISOMERASE ENZYME DNA DNA-BINDING) protein domain (PD001285) which is seen in Q9CG80_LACLA.Residues 244-321 are 82% similar to a (TOPOISOMERASE DNA ENZYME DNA-BINDING PROTEOME COMPLETE) protein domain (PD001593) which is seen in Q9CG80_LACLA.Residues 139-176 are 57% similar to a (TOPOISOMERASE GYRASE REVERSE COMPLETE) protein domain (PD301358) which is seen in Q9HZJ5_PSEAE.Residues 23-74 are 88% similar to a (TOPOISOMERASE ENZYME DNA DNA-BINDING) protein domain (PD338116) which is seen in Q9CG80_LACLA.Residues 139-176 are 92% similar to a (TOPOISOMERASE ENZYME DNA DNA-BINDING) protein domain (PD329190) which is seen in Q9CG80_LACLA.Residues 82-177 are 36% similar to a (TOPOISOMERASE DNA DNA-BINDING III PROTEOME COMPLETE) protein domain (PD363138) which is seen in Q59046_METJA.Residues 23-90 are 40% similar to a (ENZYME TOPOISOMERASE UNT ISTING) protein domain (PD336546) which is seen in TOP1_BORBU.Residues 624-702 are 40% similar to a (TOPOISOMERASE PROTEOME COMPLETE DNA) protein domain (PD346735) which is seen in Q9JWZ5_NEIMA.Residues 82-136 are 50% similar to a (TOPOISOMERASE ENZYME PLASMID RELAXING) protein domain (PD379406) which is seen in TOP1_STRCO.Residues 382-428 are 89% similar to a (TOPOISOMERASE DNA ENZYME DNA-BINDING) protein domain (PD238848) which is seen in Q9CG80_LACLA.Residues 434-560 are 77% similar to a (TOPOISOMERASE DNA ENZYME DNA-BINDING PROTEOME COMPLETE) protein domain (PD001411) which is seen in Q9CG80_LACLA.Residues 181-223 are 83% similar to a (TOPOISOMERASE DNA ENZYME DNA-BINDING COMPLETE PROTEOME) protein domain (PD011342) which is seen in Q9CG80_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 2 09:26:26 2002","Wed Jan 9 08:38:31 2002","Tue Oct 15 09:39:42 2002","Wed Jan 9 08:36:37 2002","Wed Jan 9 08:36:37 2002","Wed Jan 9 08:36:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0912 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 08:38:12 2002","Wed Jan 9 08:36:37 2002","pdb|1CY7|A Chain A, Complex Of E.Coli Dna Topoisomerase I With ... 451 1e-127pdb|1ECL| Amino Terminal 67kda Domain Of Escherichia Coli Dn... 451 1e-127pdb|1CYY|B Chain B, Crystal Structure Of The 30 Kda Fragment Of... 160 6e-040","SMU.1002","","Residues 21 to 130 (E-value = 1e-31) place SMu0912 in the Toprim family which is described as Toprim domain (PF01751)Residues 143 to 547 (E-value = 4.8e-171) place SMu0912 in the Topoisom_bac family which is described as DNA topoisomerase (PF01131)Residues 587 to 625 (E-value = 5.4e-14) place SMu0912 in the zf-C4_Topoisom family which is described as Topoisomerase DNA binding C4 zinc finger (PF01396)Residues 627 to 667 (E-value = 7.9e-12) place SMu0912 in the zf-C4_Topoisom family which is described as Topoisomerase DNA binding C4 zinc finger (PF01396)","Wed Jan 9 08:36:37 2002","24379442","","","Tse-Dinh,Y.C. and Wang,J.C.Complete nucleotide sequence of the topA gene encoding Escherichiacoli DNA topoisomerase IJ. Mol. Biol. 191 (3), 321-331 (1986)PubMed: 3029379Yu,L., Zhu,C.X., Tse-Dinh,Y.C. and Fesik,S.W.Solution structure of the C-terminal single-stranded DNA-bindingdomain of Escherichia coli topoisomerase IBiochemistry 34 (23), 7622-7628 (1995)PubMed: 7779808","","Wed Jan 9 08:55:28 2002","1","","","SMU.1002","118" "SMu0913","949332","950666","1335","ATGTCTCAATCTTATATTAATGTTGTTGGGGCTGGTCTTGCTGGCTCTGAAGCTGCTTATCAGATCGCTAAACGCGGTATTCCTGTCAAGCTTTATGAAATGCGTGGAGTCAAAAGAACACCCCAGCATAAAACAAGTAATTTTGCGGAATTAGTTTGTTCGAATTCTTTTCGTGGTGACAGTTTAACGAATGCTGTCGGTCTTCTCAAAGAAGAGATGCGCCGCTTGGACTCTATTATCATGCGAACTGGTGAAGCCCATCGTGTACCTGCAGGTGGTGCTATGGCAGTTGACCGTAGCGGCTATGCTCAAGCCGTTACGGCAGAACTTGAAAATAACCCTCTCATTCAGGTTATTCGAAACGAAGTAACTGAAATTCCTGATGATGCTATTACAGTGATTGCGACTGGTCCACTGACAAGTGACAGTCTGGCTAAAAAAATTTATAAACTAAACGGCGGTGAAGGGTTTTATTTTTATGACGCGGCGGCGCCAATTGTCGATCAATCTTCCATTGATATGGATAAGGTTTATCTCAAGTCGCGTTACGATAAGGGAGAGGCTGCCTATCTCAATTGTCCTATGACTAAGGAGGAGTTTATACGTTTTTATGAAGCTTTGATCAATGCTGAAGAAGCTCCGTTCAACTCCTTTGAAAGGGAAAAATACTTTGAAGGTTGCATGCCTATTGAGGTTATGGCCAAGCGGGGCATTAAAACATTGCTTTATGGGCCCATGAAACCAGTTGGTCTGGAATACCCACAAGACTACAAGGGGCCGCGAGATGGTGATTATAAGGCTCCCTATGCTGTTGTGCAGCTTCGACAAGATAATGCAGCTGGCAGCCTTTACAATATTGTTGGTTTTCAGACCCATCTTAAGTGGAGTGAACAAAAACGTGTCTTTTCCATGATTCCAGGTCTGGAGCAAGCACATTTCGTTCGTTATGGCGTCATGCATCGCAACTCTTACATTGACTCCCCTAATCTTCTTGCTCCTACCTTTGCAACGTGTAAAAATCCAAATCTATTCTTTGCTGGACAAATGACAGGTGTAGAGGGTTATGTTGAATCTGCAGCTTCTGGGCTTGTTGCTGGAATCAATGCTGTTCGTCGTTTCAAAGATGAAGAAGCAGTAATCTTTCCGCAAACAACAGCTATTGGTGCTTTACCGTATTATATTACACATACAAAAAGTAAGCATTTTCAACCAATGAATATTAATTTTGGTATCATCAAAGATTTGGGTGGACCACGTATTCGTGATAAGAAGAAACGTTATGAGAAGATTGCTGAGCGATCACTTAAAGATCTACAGCAATTTTTAACTGTTTAA","9.10","6.53","49541","MSQSYINVVGAGLAGSEAAYQIAKRGIPVKLYEMRGVKRTPQHKTSNFAELVCSNSFRGDSLTNAVGLLKEEMRRLDSIIMRTGEAHRVPAGGAMAVDRSGYAQAVTAELENNPLIQVIRNEVTEIPDDAITVIATGPLTSDSLAKKIYKLNGGEGFYFYDAAAPIVDQSSIDMDKVYLKSRYDKGEAAYLNCPMTKEEFIRFYEALINAEEAPFNSFEREKYFEGCMPIEVMAKRGIKTLLYGPMKPVGLEYPQDYKGPRDGDYKAPYAVVQLRQDNAAGSLYNIVGFQTHLKWSEQKRVFSMIPGLEQAHFVRYGVMHRNSYIDSPNLLAPTFATCKNPNLFFAGQMTGVEGYVESAASGLVAGINAVRRFKDEEAVIFPQTTAIGALPYYITHTKSKHFQPMNINFGIIKDLGGPRIRDKKKRYEKIAERSLKDLQQFLTV","950665","For other 'gid' genes see SMu1943 (gidA) and SMu1755 (gidB).","glucose-inhibited division protein","Cytoplasm","Matches in gapped BLAST to a previously published protein in S.mutans:residues 228-444 are 100% similar to an unnamed protein product (gi|3130071|).Several matches in gapped BLAST to glucose-inhibited division protein: residues 1-442 are 84% similar to the protein in S.pyogenes (gi|15675145|). Residues 1-444 are 80% similar to the protein from S.pneumoniae (gi|15902888|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0969 (0.0).","

InterPro
IPR002218
Family

Glucose-inhibited division protein A
PD003738	$\"[304-374]T$	GIDA
PTHR11806	$\"[171-433]T$	GIDA
PF01134	$\"[5-377]T$	GIDA
PS01281	$\"[346-369]T$	GIDA_2

InterPro
IPR004417
Family

Gid protein
TIGR00137	$\"[4-444]T$	gid

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[6-33]T$	G3DSA:3.40.50.720
SSF51905	$\"[8-378]T$	SSF51905

","BeTs to 4 clades of COG1206COG name: NAD(FAD)-utilizing enzyme apparently involved in cell divisionFunctional Class: DThe phylogenetic pattern of COG1206 is -----qvc-b-----------Number of proteins in this genome belonging to this COG is 1","***** IPB002218 (Glucose inhibited division protein A family) with a combined E-value of 1.8e-09. IPB002218F 288-342 IPB002218G 349-369","Residues 392-439 are identical to a (COMPLETE DIVISION PROTEOME INHIBITED) protein domain (PD151911) which is seen in Q9R306_STRMU.Residues 288-390 are 73% similar to a (DIVISION INHIBITED GLUCOSE COMPLETE) protein domain (PD003738) which is seen in Q9CG79_LACLA.Residues 228-287 are identical to a (COMPLETE DIVISION PROTEOME OXIDOREDUCTASE) protein domain (PD151384) which is seen in Q9R306_STRMU.Residues 150-227 are 73% similar to a (DIVISION PROTEOME COMPLETE) protein domain (PD271904) which is seen in Q9KA24_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 09:40:31 2002","Wed Jan 9 08:58:49 2002","Tue Oct 15 09:40:31 2002","Wed Jan 9 08:58:49 2002","Wed Jan 9 08:58:49 2002","Wed Jan 9 08:58:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0913 is paralogously related (blast p-value < 1e-3) to SMu1943, a predicted glucose inhibited division protein.","Mon Jan 28 17:01:06 2002","","No significant hits to the NCBI PDB database.","SMU.1003","","Residues 5 to 384 (E-value = 2.2e-140) place SMu0913 in the GIDA family which is described as Glucose inhibited division protein A (PF01134)","Wed Jan 9 08:58:49 2002","24379443","","Fujiwara,T., Terao,Y., Hoshino,T., Kawabata,S., Ooshima,T.,Sobue,S., Kimura,S. and Hamada,S.Molecular analyses of glucosyltransferase genes among strains ofStreptococcus mutansFEMS Microbiol. Lett. 161 (2), 331-336 (1998)PubMed: 9570124Shiroza,T., Ueda,S. and Kuramitsu,H.K.Sequence analysis of the gtfB gene from Streptococcus mutansJ. Bacteriol. 169 (9), 4263-4270 (1987)PubMed: 3040685","White DJ, Merod R, Thomasson B, Hartzell PL.GidA is an FAD-binding protein involved in development of Myxococcus xanthus.Mol Microbiol. 2001 Oct;42(2):503-17.PMID: 11703671 ","Tue Apr 2 14:35:48 2002","Wed Jan 9 09:05:05 2002","1","","","SMU.1003","115" "SMu0914","951112","955542","4431","ATGGACAAGAAAGTGCGTTATAAACTGCGCAAAGTTAAAAAAAGATGGGTGACAGTATCTGTTGCATCTGCTGTGATGACTTTAACTACACTTTCGGGTGGCTTGGTTAAAGCAGATTCTAATGAATCGAAATCCCAAATTTCTAATGATTCTAATACTAGTGTTGTTACTGCTAATGAAGAATCTAATGTAACAACCGAAGTGACATCTAAGCAAGAAGCTGCTAGTAGTCAAACTAATCATACAGTAACGACAATCAGTAGCTCTACTTCAGTAGTTAATCCCAAAGAGGTTGTAAGTAATCCTTATACTGTTGGGGAAACAGCTTCTAATGGTGAAAAGCTTCAAAATCAAACAACTACAGTTGACAAAACTTCTGAAGCTGCTGCTAATAATATTAGTAAACAAACAACCGAAGCTGATACAGATGTTATTGATGATAGCAATGCAGCCAATCTACAAATATTGGAAAAACTTCCCAATGTAAAAGAAATTGATGGTAAGTATTATTATTATGACAATAACGGCAAAGTTCGTACTAATTTTACATTAATTGCTGATGGCAAAATTTTACATTTTGATGAAACTGGCGCTTATACTGATACATCAATTGACACTGTAAATAAAGATATCGTCACAACAAGAAGTAATCTATACAAAAAATATAATCAAGTTTATGATCGCTCTGCACAGAGCTTTGAGCATGTTGATCATTATTTGACAGCCGAAAGTTGGTATCGTCCTAAGTACATCTTGAAGGATGGCAAAACATGGACACAGTCAACAGAAAAAGATTTTCGTCCCTTACTGATGACATGGTGGCCGAGCCAAGAAACACAGCGTCAATATGTTAACTACATGAATGCACAGCTTGGCATTAACAAGACTTATGATGATACAAGTAATCAATTGCAATTAAATATTGCAGCTGCAACTATTCAAGCAAAAATTGAGGCCAAAATTACAACTTTAAAGAATACTGATTGGCTGCGTCAGACTATTTCCGCATTTGTTAAGACACAGTCAGCTTGGAACAGTGACAGCGAAAAACCGTTTGATGATCATTTACAAAATGGAGCAGTGCTTTACGATAATGAAGGAAAATTAACGCCTTATGCTAATTCCAACTACCGTATCTTAAATCGCACCCCGACCAATCAAACTGGGAAGAAGGATCCAAGATATACAGCTGATAACACTATCGGCGGTTACGAATTCCTTTTGGCCAACGATGTGGATAATTCCAATCCTGTCGTGCAGGCCGAACAATTGAACTGGCTGCATTTTCTCATGAACTTTGGCAACATTTATGCCAATGATCCGGATGCTAACTTTGATTCCATTCGTGTTGATGCGGTGGATAATGTGGATGCTGACTTGCTCCAAATTGCTGGGGATTACCTCAAAGCTGCTAAGGGGATCCATAAAAATGATAAGGCTGCTAATGATCATTTGTCTATTTTAGAGGCATGGAGTGACAACGACACTCCTTACCTTCATGATGATGGCGACAATATGATTAATATGGACAATAAGCTGCGTTTGTCTCTATTATTTTCATTAGCTAAACCCTTAAATCAACGTTCAGGCATGAATCCTCTGATCACTAACAGTTTGGTGAATCGAACTGATGATAATGCTGAAACTGCCGCAGTCCCTTCTTATTCCTTCATCCGTGCCCATGACAGTGAAGTGCAGGATTTGATTCGTGATATCATCAAGGCAGAAATCAATCCTAATGTTGTCGGGTATTCATTCACTATGGAGGAAATCAAGAAGGCTTTCGAGATTTACAACAAAGACTTATTAGCTACAGAGAAGAAATACACACACTATAATACGGCACTTTCTTATGCCCTGCTTTTAACCAACAAATCCAGTGTGCCGCGTGTCTATTATGGGGATATGTTTACAGATGACGGGCAATACATGGCTCATAAGACGATCAATTACGAAGCCATCGAAACCCTGCTTAAAGCTCGTATTAAGTATGTTTCAGGCGGTCAAGCCATGCGCAATCAACAGGTTGGCAATTCTGAAATTATTACGTCTGTCCGCTATGGTAAAGGTGCTTTGAAAGCAACGGATACAGGGGACCGCACCACACGAACTTCAGGAGTGGCCGTGATTGAAGGCAATAACCCTTCTTTACGTTTGAAGGCTTCTGATCGCGTGGTTGTCAATATGGGAGCAGCCCATAAGAACCAAGCTTACCGACCTTTACTCTTGACCACAGATAACGGTATCAAGGCTTATCATTCCGATCAAGAAGCGGCTGGTTTGGTGCGCTACACCAATGACAGAGGGGAATTGATCTTCACAGCGGCTGATATTAAAGGCTATGCCAACCCTCAAGTTTCTGGCTATTTAGGTGTTTGGGTTCCAGTAGGCGCTGCCGCTGATCAAGATGTTCGCGTTGCGGCTAGCACGGCCCCATCAACAGATGGCAAGTCTGTGCATCAAAATGCGGCCCTTGATTCACGCGTCATGTTTGAAGGTTTCTCTAATTTCCAAGCTTTCGCCACTAAAAAAGAGGAATATACCAATGTTGTGATTGCTAAGAATGTGGATAAGTTTGCGGAATGGGGTGTCACAGATTTTGAAATGGCACCGCAGTATGTGTCTTCAACAGATGGTTCTTTCTTGGATTCTGTGATCCAAAACGGCTATGCTTTTACGGACCGTTATGACTTAGGAATTTCCAAACCTAATAAATACGGGACAGCCGATGATTTGGTGAAAGCCATCAAAGCGTTACACAGCAAGGGCATTAAGGTAATGGCTGACTGGGTGCCTGATCAAATGTATGCTTTTCCTGAAAAAGAAGTGGTAACAGCAACCCGTGTTGATAAGTTTGGAAAACCGGTTGAAGGCTCACAAATTAAGAGTGTTCTTTATGTTGCTGACAGTAAGAGTTCTGGTAAAGATCAACAAGCCAAGTATGGGGGAGCTTTCTTAGAGGAGCTGCAAGCGAAGTATCCGGAGCTTTTTGCGAGAAAACAAATTTCCACAGGGGTTCCGATGGATCCTTCTGTTAAGATTAAGCAATGGTCTGCCAAGTACTTTAATGGGACAAATATTTTAGGGCGCGGAGCAGGCTATGTCTTAAAAGATCAGGCAACTAATACTTACTTTAATATTTCAGATAATAAAGAAATAAACTTCCTTCCTAAAACATTGTTAAACCAAGATAGTCAAGTTGGTTTCTCTTATGACGGTAAAGGTTATGTTTATTATTCAACGAGTGGTTACCAAGCCAAAAATACTTTCATCAGCGAAGGTGATAAATGGTATTATTTTGATAATAACGGTTATATGGTCACTGGTGCTCAATCAATTAACGGTGTTAATTATTATTTCTTATCAAATGGTCTACAGCTCAGAGATGCTATTCTTAAGAATGAAGATGGAACTTACGCTTATTATGGAAATGACGGTCGCCGTTATGAAAATGGTTATTATCAATTCATGAGTGGTGTATGGCGTCACTTCAATAATGGTGAAATGAGTGTTGGATTAACTGTAATTGATGGTCAGGTTCAATACTTTGATGAAATGGGCTATCAAGCCAAAGGAAAATTTGTAACAACTGCCGATGGTAAAATAAGATATTTTGATAAGCAATCTGGGAACATGTATCGTAATCGTTTTATTGAAAACGAAGAAGGTAAATGGCTGTATCTCGGTGAAGATGGTGCAGCAGTGACAGGATCTCAAACCATTAACGGTCAACACCTGTACTTTAGAGCAAACGGTGTTCAGGTCAAGGGTGAATTTGTCACTGACCGCTACGGCCGTATCAGCTATTACGACAGCAATTCAGGGGATCAAATCCGCAACCGCTTTGTCCGCAATGCTCAGGGTCAGTGGTTCTACTTTGATAACAATGGCTATGCCGTAACCGGTGCCAGAACCATTAACGGTCAACACCTATACTTTAGAGCAAACGGTGTTCAGGTCAAGGGTGAATTTGTCACTGACCGCCACGGTCGTATCAGCTATTACGACGGCAATTCAGGGGATCAAATCCGCAACCGCTTTGTCCGCAATGCTCAGGGTCAATGGTTCTACTTTGATAACAATGGCTATGCCGTAACCGGTGCCAGAACCATTAACGGTCAACACCTATACTTTAGAGCAAACGGTGTTCAGGTCAAGGGTGAATTTGTCACTGACCGCTACGGCCGTATCAGCTATTACGACAGCAATTCAGGGGATCAAATCCGCAACCGCTTTGTCCGCAATGCTCAGGGTCAGTGGTTCTACTTTGATAACAATGGCTATGCCGTAACCGGTGCCAGAACCATTAACGGTCAACACCTGTACTTTAGAGCAAACGGTGTTCAGGTCAAAGGTGAATTTGTCACTGACCGCTACGGCCGTATCAGTTATTACGATGCTAACTCTGGAGAACGAGTTCGGATTAACTAA","7.20","1.66","165733","MDKKVRYKLRKVKKRWVTVSVASAVMTLTTLSGGLVKADSNESKSQISNDSNTSVVTANEESNVTTEVTSKQEAASSQTNHTVTTISSSTSVVNPKEVVSNPYTVGETASNGEKLQNQTTTVDKTSEAAANNISKQTTEADTDVIDDSNAANLQILEKLPNVKEIDGKYYYYDNNGKVRTNFTLIADGKILHFDETGAYTDTSIDTVNKDIVTTRSNLYKKYNQVYDRSAQSFEHVDHYLTAESWYRPKYILKDGKTWTQSTEKDFRPLLMTWWPSQETQRQYVNYMNAQLGINKTYDDTSNQLQLNIAAATIQAKIEAKITTLKNTDWLRQTISAFVKTQSAWNSDSEKPFDDHLQNGAVLYDNEGKLTPYANSNYRILNRTPTNQTGKKDPRYTADNTIGGYEFLLANDVDNSNPVVQAEQLNWLHFLMNFGNIYANDPDANFDSIRVDAVDNVDADLLQIAGDYLKAAKGIHKNDKAANDHLSILEAWSDNDTPYLHDDGDNMINMDNKLRLSLLFSLAKPLNQRSGMNPLITNSLVNRTDDNAETAAVPSYSFIRAHDSEVQDLIRDIIKAEINPNVVGYSFTMEEIKKAFEIYNKDLLATEKKYTHYNTALSYALLLTNKSSVPRVYYGDMFTDDGQYMAHKTINYEAIETLLKARIKYVSGGQAMRNQQVGNSEIITSVRYGKGALKATDTGDRTTRTSGVAVIEGNNPSLRLKASDRVVVNMGAAHKNQAYRPLLLTTDNGIKAYHSDQEAAGLVRYTNDRGELIFTAADIKGYANPQVSGYLGVWVPVGAAADQDVRVAASTAPSTDGKSVHQNAALDSRVMFEGFSNFQAFATKKEEYTNVVIAKNVDKFAEWGVTDFEMAPQYVSSTDGSFLDSVIQNGYAFTDRYDLGISKPNKYGTADDLVKAIKALHSKGIKVMADWVPDQMYAFPEKEVVTATRVDKFGKPVEGSQIKSVLYVADSKSSGKDQQAKYGGAFLEELQAKYPELFARKQISTGVPMDPSVKIKQWSAKYFNGTNILGRGAGYVLKDQATNTYFNISDNKEINFLPKTLLNQDSQVGFSYDGKGYVYYSTSGYQAKNTFISEGDKWYYFDNNGYMVTGAQSINGVNYYFLSNGLQLRDAILKNEDGTYAYYGNDGRRYENGYYQFMSGVWRHFNNGEMSVGLTVIDGQVQYFDEMGYQAKGKFVTTADGKIRYFDKQSGNMYRNRFIENEEGKWLYLGEDGAAVTGSQTINGQHLYFRANGVQVKGEFVTDRYGRISYYDSNSGDQIRNRFVRNAQGQWFYFDNNGYAVTGARTINGQHLYFRANGVQVKGEFVTDRHGRISYYDGNSGDQIRNRFVRNAQGQWFYFDNNGYAVTGARTINGQHLYFRANGVQVKGEFVTDRYGRISYYDSNSGDQIRNRFVRNAQGQWFYFDNNGYAVTGARTINGQHLYFRANGVQVKGEFVTDRYGRISYYDANSGERVRIN","955550","For other 'gtf' genes see SMu0827 (gtfD) and SMu0915 (gtfC).From Genbank [gi:6166191]:This enzyme is believed to play a role in the production of extracellular glucans that are thought to play a key role in the development of dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.Note tandem repeats at 954839,955519. ","glucosyltransferase-I","Extracellular","Matches in gapped BLAST to glucosyltransferase-I: residues 18-1479 are 95% similar to a previously published enzyme in S.mutans (gi3130079).Residues 18-1476 are 55% similar, residues 1075-1368 are 31% similar and residues 952-1238 are 30% similar to to the enzyme in S.sobrinus (gi940427). SMu0914 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002479
Repeat

Putative cell wall binding repeat
PF01473	$\"[1091-1109]T$ $\"[1283-1302]T$ $\"[1348-1367]T$ $\"[1413-1432]T$	CW_binding_1
PS51170	$\"[159-178]T$ $\"[179-199]T$ $\"[1090-1109]T$ $\"[1110-1129]T$ $\"[1173-1192]T$ $\"[1217-1237]T$ $\"[1238-1257]T$ $\"[1282-1302]T$ $\"[1303-1322]T$ $\"[1347-1367]T$ $\"[1368-1387]T$ $\"[1412-1432]T$ $\"[1433-1452]T$	CW

InterPro
IPR003318
Domain

Glycoside hydrolase, family 70, catalytic core
PF02324	$\"[269-1077]T$	Glyco_hydro_70

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[370-638]T$ $\"[853-937]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:2.10.270.10	$\"[1070-1130]T$ $\"[1154-1238]T$ $\"[1239-1323]T$ $\"[1337-1388]T$ $\"[1397-1453]T$	no description
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[15-35]?$	transmembrane_regions

","BeTs to 4 clades of COG0296COG name: 1,4-alpha-glucan branching enzymeFunctional Class: GThe phylogenetic pattern of COG0296 is ----yq-cebRh------in-Number of proteins in this genome belonging to this COG is 4","***** IPB003318 (Glucosyltransferase S precursor) with a combined E-value of 0. IPB003318A 1-19 IPB003318B 232-283 IPB003318C 306-349 IPB003318D 354-365 IPB003318E 402-450 IPB003318F 473-517 IPB003318G 553-597 IPB003318H 625-669 IPB003318I 680-710 IPB003318J 713-758 IPB003318K 773-816 IPB003318L 824-849 IPB003318M 871-890 IPB003318N 891-932 IPB003318O 933-959 IPB003318P 963-1007 IPB003318Q 1008-1038 IPB003318R 1098-1131 IPB003318R 1161-1194 IPB003318R 167-200 IPB003318R 1078-1111","Residues 1340-1450 are 50% similar to a (TRANSFERASE SURFACE PSPC DEXTRANSUCRASE) protein domain (PD000439) which is seen in O69397_STRMU.Residues 18-79 are 96% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002249) which is seen in GTFB_STRMU.Residues 1328-1415 are 34% similar to a (GLUCAN-BINDING GBP PRECURSOR REPEAT) protein domain (PD236206) which is seen in Q54447_STRMU.Residues 80-176 are 87% similar to a (CARIES GLYCOSYLTRANSFERASE) protein domain (PD011936) which is seen in GTFB_STRMU.Residues 1367-1458 are 33% similar to a (DEXTRANSUCRASE GLYCOSYLTRANSFERASE) protein domain (PD174018) which is seen in Q9ZAR4_LEUME.Residues 1415-1460 are 56% similar to a (TRANSFERASE SIGNAL 6-GLUCOSYLTRANSFERASE) protein domain (PD016627) which is seen in Q00599_STRSL.Residues 1081-1138 are 48% similar to a (TRANSFERASE PRECURSOR GLUCOSYLTRANSFERASE) protein domain (PD149701) which is seen in Q9WXJ5_BBBBB.Residues 1389-1450 are 42% similar to a (TRANSFERASE SIGNAL PRECURSOR) protein domain (PD285093) which is seen in O69397_STRMU.Residues 1140-1208 are 44% similar to a (S CARIES GLYCOSYLTRANSFERASE PRECURSOR) protein domain (PD242668) which is seen in Q9WXJ5_BBBBB.Residues 1128-1222 are 42% similar to a (TRANSFERASE PRECURSOR GLUCOSYLTRANSFERASE) protein domain (PD203969) which is seen in Q55265_STRSL.Residues 939-999 are identical to a (TRANSFERASE DEXTRANSUCRASE) protein domain (PD149672) which is seen in O69388_STRMU.Residues 1130-1187 are 62% similar to a (TRANSFERASE GLUCOSYLTRANSFERASE-SI) protein domain (PD186762) which is seen in O69397_STRMU.Residues 1041-1104 are 61% similar to a (CARIES GLYCOSYLTRANSFERASE) protein domain (PD268663) which is seen in GTFB_STRMU.Residues 1001-1040 are identical to a (TRANSFERASE DEXTRANSUCRASE) protein domain (PD341788) which is seen in O69397_STRMU.Residues 828-936 are 64% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002312) which is seen in Q00599_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 13:26:00 2007","Wed Jan 9 09:08:56 2002","Thu Feb 3 14:02:32 2005","Wed Jan 9 09:08:56 2002","Wed Jan 9 09:08:56 2002","Wed Jan 9 09:08:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0914 is paralogously related (blast p-value < 1e-3) to SMu0915, a predicted glucosyltransferase-SI; SMu0827,a predicted glucosyltransferase-S; SMu1916, a predicted glucan-binding protein; SMu0700, a predicted BglB-like protein; SMu1843,a predicted evansucrase (fructosyltransferase) (beta-D-fructofuranosyl transferase); SMu0057,a predicted conserved hypothetical protein; and SMu1445, a predicted intracellular a-amylase.","Thu Mar 21 09:28:41 2002","","No significant hits to the NCBI PDB database.","SMU.1004","","Residues 1100 to 1119 (E-value = 4.3e-09) place SMu0914 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1228 to 1247 (E-value = 7.3e-08) place SMu0914 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1293 to 1312 (E-value = 2.1e-09) place SMu0914 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1358 to 1377 (E-value = 2.1e-09) place SMu0914 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1423 to 1442 (E-value = 2.1e-09) place SMu0914 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)","Thu Feb 3 14:02:32 2005","24379444",""," Shemesh M, Tam A, Feldman M, Steinberg D.,Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases.Carbohydr Res. 2006 Sep 4;341(12):2090-7. Epub 2006 Jun 9.PMID: 16764842 Senadheera MD, Lee AW, Hung DC, Spatafora GA, Goodman SD, Cvitkovitch DG.The Streptococcus mutans vicX gene product modulates gtfB/C Expression, Biofilm Formation, Genetic Competence and Oxidative Stress Tolerance.Bacteriol. 2006 Nov 17;PMID: 17114248Tagawa H, Hayakawa M, Shibata Y, Fukushima K, Lee MS, Shiroza T, Abiko Y.Production of functional ScFv inhibiting Streptococcus mutans glucosyltransferase activity from a hybridoma P126.Hybrid Hybridomics. 2004 Oct;23(5):305-10.PMID: 15672609Tamesada M, Kawabata S, Fujiwara T, Hamada S.Synergistic effects of streptococcal glucosyltransferases on adhesive biofilm formation.J Dent Res. 2004 Nov;83(11):874-9.PMID: 15505239Kopec LK, Vacca Smith AM, Wunder D, Ng-Evans L, Bowen WH.Influence of antibody on the structure of glucans.Caries Res. 2002 Mar-Apr;36(2):108-15.PMID: 12037367Nomura Y, Eto A, Hanada N, Senpuku H.Identification of the peptide motifs that interact with HLA-DR8 (DRB1*0802) in Streptococcus mutans proteins.Oral Microbiol Immunol. 2002 Aug;17(4):209-14.PMID: 12121470Fujiwara,T., Terao,Y., Hoshino,T., Kawabata,S., Ooshima,T.,Sobue,S., Kimura,S. and Hamada,S.Molecular analyses of glucosyltransferase genes among strains ofStreptococcus mutansFEMS Microbiol. Lett. 161 (2), 331-336 (1998)PubMed: 9570124Shiroza,T., Ueda,S. and Kuramitsu,H.K.Sequence analysis of the gtfB gene from Streptococcus mutansJ. Bacteriol. 169 (9), 4263-4270 (1987)PubMed: 3040685Ueda,S., Shiroza,T. and Kuramitsu,H.K.Sequence analysis of the gtfC gene from Streptococcus mutans GS-5Gene 69 (1), 101-109 (1988)PubMed: 2976010Honda O, Kato C, Kuramitsu HKNucleotide sequence of the Streptococcus mutans gtfD gene encoding the glucosyltransferase-S enzyme.J Gen Microbiol 1990 Oct;136 ( Pt 10):2099-105PubMed: 2148600PMID: 2148600","Abo,H., Matsumura,T., Kodama,T., Ohta,H., Fukui,K., Kato,K. andKagawa,H.Peptide sequences for sucrose splitting and glucan binding withinStreptococcus sobrinus glucosyltransferase (water-insoluble glucansynthetase)J. Bacteriol. 173 (3), 989-996 (1991)PubMed: 1704006Koo H, Seils J, Abranches J, Burne RA, Bowen WH, Quivey RG.Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.Antimicrob Agents Chemother. 2006 Feb;50(2):542-6.PMID: 16436708Biswas S, Biswas I.Regulation of the glucosyltransferase (gtfBC) operon by CovR in Streptococcus mutans.J Bacteriol. 2006 Feb;188(3):988-98.PMID: 16428403Chen PM, Chen JY, Chia JS.Differential regulation of Streptococcus mutans gtfBCD genes in response to copper ions.Arch Microbiol. 2006 Mar;185(2):127-35.PMID: 16395551","Fri Mar 16 12:20:33 2007","Tue Apr 24 13:26:00 2007","1","","","SMU.1004","" "SMu0915","955738","960105","4368","ATGGAAAAGAAAGTACGTTTTAAATTACGTAAAGTAAAGAAAAGATGGGTGACAGTATCTGTTGCTTCAGCTGTAGTGACTTTGACCTCTCTTTCAGGAAGTCTAGTAAAAGCAGATTCAACTGACGACCGTCAACAGGCGGTTACAGAATCTCAGGCTAGTCTTGTGACGACAAGTGAAGCAGCAAAAGAAACTCTGACTGCTACTGATACAAGTACAGCAACTTCAGCAACATCTCAACCAACCGCCACTGTTACTGATAATGTTTCTACAACAAACCAGTCTACAAATACTACTGCTAATACAGCTAATTTTGACGTTAAACCAACAACAACTTCGGAACAGTCTAAAACTGATAATAGTGACAAAATAATTGCTACATCAAAAGCGGTAAACCGTTTAACTGCGACTGGTAAATTTGTTCCTGCTAACAATAATACTGCACATTCAAGAACTGTCACTGATAAAATAGTTCCAATAAAACCAAAGATTGGTAAATTAAAACAGCCGTCATCACTTAGTCAAGATGATATTGCAGCCTTAGGTAATGTCAAAAATATCAGAAAAGTGAACGGTAAATATTATTATTATAAAGAAGATGGAACTCTTCAAAAGAATTATGCTTTAAATATTAATGGGAAAACTTTCTTCTTTGATGAAACAGGAGCATTATCAAATAATACTTTACCTAGTAAAAAGGGTAATATCACTAATAATGATAACACTAACAGCTTTGCTCAATATAATCAGGTCTATAGTACAGATGCTGCAAACTTCGAACATGTTGATCATTATTTGACAGCTGAGAGTTGGTATCGTCCTAAGTACATCTTGAAGGATGGTAAAACATGGACACAGTCAACAGAAAAAGATTTCCGTCCCTTATTGATGACATGGTGGCCTGACCAAGAAACGCAGCGTCAATATGTTAACTACATGAATGCACAGCTTGGTATTCATCAAACATACAATACAGCAACCAGTCCGCTTCAATTGAATTTAGCTGCTCAGACAATACAAACTAAGATCGAAGAAAAAATCACTGCAGAAAAGAATACCAATTGGCTGCGTCAGACTATTTCCGCATTTGTTAAGACACAGTCAGCTTGGAACAGTGACAGCGAAAAACCATTTGATGATCACTTACAAAAAGGGGCATTGCTTTACAGTAATAATAGCAAACTAACTTCACAGGCTAATTCCAACTACCGTATCTTAAATCGCACCCCGACCAATCAAACTGGGAAGAAGGATCCAAGGTATACAGCTGATCGCACCATTGGCGGTTACGAATTCCTTTTGGCCAACGATGTGGATAATTCCAATCCTGTCGTGCAGGCCGAACAATTGAACTGGCTCCACTTTCTCATGAACTTTGGCAACATTTATGCCAATGATCCGGATGCTAACTTTGATTCCATTCGTGTTGATGCGGTGGATAATGTGGATGCTGACTTGCTCCAAATTGCTGGGGATTACCTCAAAGCTGCTAAGGGGATCCATAAAAATGATAAGGCTGCTAATGATCATTTGTCTATTTTAGAGGCATGGAGTTATAATGATACTCCTTACCTTCATGATGATGGCGACAATATGATTAACATGGATAACAGGTTACGTCTTTCCTTGCTTTATTCATTAGCTAAACCTTTAAATCAACGTTCAGGCATGAATCCTCTGATCACTAACAGTTTGGTGAATCGAACTGATGATAATGCTGAAACTGCCGCAGTCCCTTCTTATTCCTTCATCCGTGCCCATGACAGTGAAGTGCAGGACTTGATTCGCAATATTATTAGAGCAGAAATCAATCCTAATGTTGTCGGGTATTCTTTCACCATGGAGGAAATTAAGAAGGCTTTCGAGATTTACAACAAAGACTTATTAGCTACAGAGAAGAAATACACACACTATAATACGGCACTTTCTTATGCCCTGCTTTTAACCAACAAATCCAGTGTGCCGCGTGTCTATTATGGGGATATGTTTACAGATGACGGGCAATACATGGCTCATAAGACGATCAATTACGAAGCCATCGAAACCCTGCTTAAAGCTCGTATTAAGTATGTTTCAGGCGGTCAAGCCATGCGCAATCAACAGGTTGGCAATTCTGAAATTATTACGTCTGTCCGCTATGGTAAAGGTGCTTTGAAAGCAACGGATACAGGGGACCGCACCACACGAACTTCAGGAGTGGCCGTGATTGAAGGCAATAACCCTTCTTTACGTTTGAAGGCTTCTGATCGCGTGGTTGTCAATATGGGAGCAGCCCATAAGAACCAAGCTTACCGACCTTTACTCTTGACCACAGATAACGGTATCAAGGCTTATCATTCCGATCAAGAAGCGGCTGGTTTGGTGCGCTACACCAATGACAGAGGGGAATTGATCTTCACAGCGGCTGATATTAAAGGCTATGCCAACCCTCAAGTTTCTGGCTATTTAGGTGTTTGGGTTCCAGTAGGCGCTGCCGCTGATCAAGATGTTCGCGTTGCGGCTAGCACGGCCCCATCAACAGATGGCAAGTCTGTGCATCAAAATGCGGCCCTTGATTCACGCGTCATGTTTGAAGGTTTCTCTAATTTCCAAGCTTTCGCCACTAAAAAAGAGGAATATACCAATGTTGTGATTGCTAAGAATGTGGATAAGTTTGCGGAATGGGGTGTCACAGATTTTGAAATGGCACCGCAGTATGTGTCTTCAACAGATGGTTCTTTCTTGGATTCTGTGATCCAAAACGGCTATGCTTTTACGGACCGTTATGATTTGGGAATTTCCAAACCTAATAAATACGGGACAGCCGATGATTTGGTGAAAGCCATCAAAGCGTTACACAGCAAGGGCATTAAGGTAATGGCTGACTGGGTGCCTGATCAAATGTATGCTCTCCCTGAAAAAGAAGTGGTAACAGCAACCCGTGTTGATAAGTATGGGACTCCTGTTGCAGGAAGTCAGATCAAAAACACCCTTTATGTAGTTGATGGTAAGAGTTCTGGTAAAGATCAACAAGCCAAGTATGGGGGAGCTTTCTTAGAGGAGCTGCAAGCTAAATATCCGGAGCTTTTTGCGAGAAAACAAATTTCCACAGGGGTTCCGATGGATCCTTCTGTTAAGATTAAGCAATGGTCTGCCAAGTACTTTAATGGGACAAATATTTTAGGGCGCGGAGCAGGCTATGTCTTAAAAGATCAGGCAACCAATACTTACTTCAGTCTTGTTTCAGACAACACCTTCCTTCCTAAATCGTTAGTTAACCCAAATCACGGAACAAGCAGTTCTGTAACTGGATTGGTATTTGATGGTAAAGGTTATGTTTATTATTCAACGAGTGGTAACCAAGCTAAAAATGCTTTCATTAGCTTAGGAAATAATTGGTATTATTTCGATAATAACGGTTATATGGTCACTGGTGCTCAATCAATTAACGGTGCTAATTATTATTTCTTATCAAATGGTATTCAATTAAGAAATGCTATTTATGATAATGGTAATAAAGTATTGTCTTATTATGGAAATGATGGCCGTCGTTATGAAAATGGTTACTATCTCTTTGGTCAACAATGGCGTTATTTCCAAAATGGTATTATGGCTGTCGGCTTAACACGTATTCATGGTGCTGTTCAATACTTTGATGCTTCTGGGTTCCAAGCTAAAGGACAGTTTATTACAACTGCTGATGGAAAGCTGCGTTACTTTGATAGAGACTCAGGAAATCAAATTTCAAATCGTTTTGTTAGAAATTCCAAGGGAGAATGGTTCTTATTTGATCACAATGGTGTCGCTGTAACCGGTACTGTAACGTTCAATGGACAACGTCTTTACTTTAAACCTAATGGTGTTCAAGCCAAAGGAGAATTTATCAGAGATGCAGATGGACATCTAAGATATTATGATCCTAATTCCGGAAATGAAGTTCGTAATCGCTTTGTTAGAAATTCCAAGGGAGAATGGTTCTTATTTGATCACAATGGTATCGCTGTAACTGGTACCAGAGTTGTTAATGGACAGCGCCTCTATTTTAAGTCTAATGGTGTTCAGGCTAAGGGAGAGCTCATTACAGAGCGTAAAGGTCGTATCAAATACTATGATCCTAATTCCGGAAATGAAGTTCGTAATCGTTATGTGAGAACGTCATCAGGAAACTGGTACTATTTTGGCAATGATGGCTATGCCTTAATTGGTTGGCATGTTGTTGAAGGAAGACGTGTTTACTTTGATGAAAATGGTGTTTATCGTTATGCCAGTCATGATCAAAGAAACCACTGGGATTATGATTACAGAAGAGACTTTGGTCGTGGCAGCAGCAGTGCTGTTCGTTTTAGACACTCTCGTAATGGATTCTTTGACAATTTCTTTAGATTTTAA","10.00","27.12","162970","MEKKVRFKLRKVKKRWVTVSVASAVVTLTSLSGSLVKADSTDDRQQAVTESQASLVTTSEAAKETLTATDTSTATSATSQPTATVTDNVSTTNQSTNTTANTANFDVKPTTTSEQSKTDNSDKIIATSKAVNRLTATGKFVPANNNTAHSRTVTDKIVPIKPKIGKLKQPSSLSQDDIAALGNVKNIRKVNGKYYYYKEDGTLQKNYALNINGKTFFFDETGALSNNTLPSKKGNITNNDNTNSFAQYNQVYSTDAANFEHVDHYLTAESWYRPKYILKDGKTWTQSTEKDFRPLLMTWWPDQETQRQYVNYMNAQLGIHQTYNTATSPLQLNLAAQTIQTKIEEKITAEKNTNWLRQTISAFVKTQSAWNSDSEKPFDDHLQKGALLYSNNSKLTSQANSNYRILNRTPTNQTGKKDPRYTADRTIGGYEFLLANDVDNSNPVVQAEQLNWLHFLMNFGNIYANDPDANFDSIRVDAVDNVDADLLQIAGDYLKAAKGIHKNDKAANDHLSILEAWSYNDTPYLHDDGDNMINMDNRLRLSLLYSLAKPLNQRSGMNPLITNSLVNRTDDNAETAAVPSYSFIRAHDSEVQDLIRNIIRAEINPNVVGYSFTMEEIKKAFEIYNKDLLATEKKYTHYNTALSYALLLTNKSSVPRVYYGDMFTDDGQYMAHKTINYEAIETLLKARIKYVSGGQAMRNQQVGNSEIITSVRYGKGALKATDTGDRTTRTSGVAVIEGNNPSLRLKASDRVVVNMGAAHKNQAYRPLLLTTDNGIKAYHSDQEAAGLVRYTNDRGELIFTAADIKGYANPQVSGYLGVWVPVGAAADQDVRVAASTAPSTDGKSVHQNAALDSRVMFEGFSNFQAFATKKEEYTNVVIAKNVDKFAEWGVTDFEMAPQYVSSTDGSFLDSVIQNGYAFTDRYDLGISKPNKYGTADDLVKAIKALHSKGIKVMADWVPDQMYALPEKEVVTATRVDKYGTPVAGSQIKNTLYVVDGKSSGKDQQAKYGGAFLEELQAKYPELFARKQISTGVPMDPSVKIKQWSAKYFNGTNILGRGAGYVLKDQATNTYFSLVSDNTFLPKSLVNPNHGTSSSVTGLVFDGKGYVYYSTSGNQAKNAFISLGNNWYYFDNNGYMVTGAQSINGANYYFLSNGIQLRNAIYDNGNKVLSYYGNDGRRYENGYYLFGQQWRYFQNGIMAVGLTRIHGAVQYFDASGFQAKGQFITTADGKLRYFDRDSGNQISNRFVRNSKGEWFLFDHNGVAVTGTVTFNGQRLYFKPNGVQAKGEFIRDADGHLRYYDPNSGNEVRNRFVRNSKGEWFLFDHNGIAVTGTRVVNGQRLYFKSNGVQAKGELITERKGRIKYYDPNSGNEVRNRYVRTSSGNWYYFGNDGYALIGWHVVEGRRVYFDENGVYRYASHDQRNHWDYDYRRDFGRGSSSAVRFRHSRNGFFDNFFRF","960113","For other 'gtf' genes see SMu0827 (gtfD) and SMu0914 (gtfB).Note tandem repeats at 959475,959869.","glucosyltransferase-SI","Extracellular","Matches in gapped BLAST to glucosyltransferase-SI:residues 33-1455 are 95% similar to previously published enzyme in S.mutans (gi3130095). Residues 107-1414 are 59% similar and residues 1101-1263 are 29% similar to the enzyme from S.sobrinus (gi450874).SMu0915 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002479
Repeat

Putative cell wall binding repeat
PF01473	$\"[1117-1135]T$ $\"[1373-1392]T$	CW_binding_1
PS51170	$\"[184-203]T$ $\"[205-224]T$ $\"[1116-1135]T$ $\"[1136-1155]T$ $\"[1219-1239]T$ $\"[1242-1262]T$ $\"[1263-1282]T$ $\"[1307-1327]T$ $\"[1328-1347]T$ $\"[1372-1392]T$ $\"[1393-1412]T$	CW

InterPro
IPR003318
Domain

Glycoside hydrolase, family 70, catalytic core
PF02324	$\"[295-1103]T$	Glyco_hydro_70

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[379-664]T$ $\"[877-978]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
G3DSA:2.10.270.10	$\"[1091-1193]T$ $\"[1194-1322]T$ $\"[1324-1430]T$	G3DSA:2.10.270.10
SSF51445	$\"[421-686]T$ $\"[850-1000]T$	SSF51445
SSF69360	$\"[184-263]T$ $\"[1047-1192]T$	SSF69360

","BeTs to 5 clades of COG0296COG name: 1,4-alpha-glucan branching enzymeFunctional Class: GThe phylogenetic pattern of COG0296 is ----yq-cebRh------in-Number of proteins in this genome belonging to this COG is 4","***** IPB003318 (Glucosyltransferase S precursor) with a combined E-value of 0. IPB003318A 1-19 IPB003318B 258-309 IPB003318C 332-375 IPB003318D 380-391 IPB003318E 428-476 IPB003318F 499-543 IPB003318G 579-623 IPB003318H 651-695 IPB003318I 706-736 IPB003318J 739-784 IPB003318K 799-842 IPB003318L 850-875 IPB003318M 897-916 IPB003318N 917-958 IPB003318O 959-985 IPB003318P 989-1033 IPB003318Q 1034-1064 IPB003318R 1124-1157 IPB003318R 1186-1219 IPB003318R 1104-1137","Residues 1411-1455 are identical to a (TRANSFERASE GLUCOSYLTRANSFERASE-SI) protein domain (PD013334) which is seen in O69397_STRMU.Residues 1350-1411 are 53% similar to a (TRANSFERASE SURFACE PSPC DEXTRANSUCRASE) protein domain (PD000439) which is seen in GTFB_STRMU.Residues 33-115 are 51% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002249) which is seen in O69388_STRMU.Residues 1293-1378 are 35% similar to a (GLUCAN-BINDING GBP PRECURSOR REPEAT) protein domain (PD236206) which is seen in Q54447_STRMU.Residues 1262-1349 are 38% similar to a (DEXTRANSUCRASE GLYCOSYLTRANSFERASE) protein domain (PD174018) which is seen in Q9EZH5_LEUME.Residues 116-202 are identical to a (TRANSFERASE GLUCOSYLTRANSFERASE-SI CARIES) protein domain (PD011937) which is seen in O69391_STRMU.Residues 1107-1163 are 47% similar to a (TRANSFERASE PRECURSOR GLUCOSYLTRANSFERASE) protein domain (PD149701) which is seen in Q9WXJ5_BBBBB.Residues 1348-1410 are 44% similar to a (TRANSFERASE SIGNAL PRECURSOR) protein domain (PD285093) which is seen in O69397_STRMU.Residues 1170-1233 are 45% similar to a (S CARIES GLYCOSYLTRANSFERASE PRECURSOR) protein domain (PD242668) which is seen in Q9WXJ5_BBBBB.Residues 1291-1377 are 34% similar to a (TRANSFERASE PRECURSOR GLUCOSYLTRANSFERASE) protein domain (PD203969) which is seen in Q55265_STRSL.Residues 964-1025 are identical to a (TRANSFERASE DEXTRANSUCRASE) protein domain (PD149672) which is seen in O69397_STRMU.Residues 1156-1212 are 98% similar to a (TRANSFERASE GLUCOSYLTRANSFERASE-SI) protein domain (PD186762) which is seen in O69397_STRMU.Residues 1067-1130 are 61% similar to a (CARIES GLYCOSYLTRANSFERASE) protein domain (PD268663) which is seen in GTFB_STRMU.Residues 1027-1066 are identical to a (TRANSFERASE DEXTRANSUCRASE) protein domain (PD341788) which is seen in O69397_STRMU.Residues 156-226 are 35% similar to a (TRANSFERASE PRECURSOR GLUCOSYLTRANSFERASE) protein domain (PD064867) which is seen in Q55264_STRSL.Residues 854-962 are 64% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002312) which is seen in Q00599_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 13:26:33 2007","Wed Jan 9 11:04:41 2002","Thu Feb 3 14:56:03 2005","Wed Jan 9 11:03:37 2002","Wed Jan 9 11:03:37 2002","Wed Jan 9 11:03:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0915 is paralogously related (blast p-value < 1e-3) to SMu0914, a predicted glucosyltransferase-I; SMu0827,a predicted glucosyltransferase-S; SMu1916, a predicted glucan-binding protein; SMu0700,a predicted BglB-like protein; SMu1843,a predicted evansucrase (fructosyltransferase) beta-D-fructofuranosyl transferase); SMu1445, a predicted intracellular a-amylase; SMu1947,a predicted surface protein; and SMu0897, a predicted wall-associated protein A precursor.","Mon Jan 28 17:17:18 2002","","No significant hits to the NCBI PDB database.","SMU.1005","","Residues 1126 to 1145 (E-value = 2.2e-09) place SMu0915 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1253 to 1272 (E-value = 4.3e-05) place SMu0915 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1318 to 1337 (E-value = 3.8e-05) place SMu0915 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 1383 to 1402 (E-value = 2.9e-06) place SMu0915 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)","Thu Feb 3 14:56:03 2005","24379445",""," Shemesh M, Tam A, Feldman M, Steinberg D.,Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases.Carbohydr Res. 2006 Sep 4;341(12):2090-7. Epub 2006 Jun 9.PMID: 16764842Senadheera MD, Lee AW, Hung DC, Spatafora GA, Goodman SD, Cvitkovitch DG.The Streptococcus mutans vicX gene product modulates gtfB/C Expression, Biofilm Formation, Genetic Competence and Oxidative Stress Tolerance.Bacteriol. 2006 Nov 17;PMID: 17114248Tamesada M, Kawabata S, Fujiwara T, Hamada S.Synergistic effects of streptococcal glucosyltransferases on adhesive biofilm formation.J Dent Res. 2004 Nov;83(11):874-9.PMID: 15505239Van Der Ploeg JR, Guggenheim B.Deletion of gtfC of Streptococcus mutans has no influence on the composition of a mixed-species in vitro biofilm model of supragingival plaque.Eur J Oral Sci. 2004 Oct;112(5):433-8.PMID: 15458503Chia JS, Lien HT, Hsueh PR, Chen PM, Sun A, Chen JY.Induction of cytokines by glucosyltransferases of streptococcus mutans.Clin Diagn Lab Immunol. 2002 Jul;9(4):892-7.PMID: 12093691Kopec LK, Vacca Smith AM, Wunder D, Ng-Evans L, Bowen WH.Influence of antibody on the structure of glucans.Caries Res. 2002 Mar-Apr;36(2):108-15.PMID: 12037367Nomura Y, Eto A, Hanada N, Senpuku H.Identification of the peptide motifs that interact with HLA-DR8 (DRB1*0802) in Streptococcus mutans proteins.Oral Microbiol Immunol. 2002 Aug;17(4):209-14.PMID: 12121470Fujiwara,T., Terao,Y., Hoshino,T., Kawabata,S., Ooshima,T.,Sobue,S., Kimura,S. and Hamada,S.Molecular analyses of glucosyltransferase genes among strains ofStreptococcus mutansFEMS Microbiol. Lett. 161 (2), 331-336 (1998)PubMed: 9570124Ueda,S., Shiroza,T. and Kuramitsu,H.K.Sequence analysis of the gtfC gene from Streptococcus mutans GS-5Gene 69 (1), 101-109 (1988)PubMed: 2976010Shiroza T, Ueda S, Kuramitsu HKSequence analysis of the gtfB gene from Streptococcus mutans.J Bacteriol 1987 Sep;169(9):4263-70PubMed: 3040685PMID: 3040685Honda O, Kato C, Kuramitsu HKNucleotide sequence of the Streptococcus mutans gtfD gene encoding the glucosyltransferase-S enzyme.J Gen Microbiol 1990 Oct;136 ( Pt 10):2099-105PubMed: 2148600PMID: 2148600Banas,J.A., Russell,R.R. and Ferretti,J.J.Sequence analysis of the gene for the glucan-binding protein ofStreptococcus mutans IngbrittInfect. Immun. 58 (3), 667-673 (1990)PubMed: 2307516","Abo,H., Matsumura,T., Kodama,T., Ohta,H., Fukui,K., Kato,K. andKagawa,H.Peptide sequences for sucrose splitting and glucan binding withinStreptococcus sobrinus glucosyltransferase (water-insoluble glucansynthetase)J. Bacteriol. 173 (3), 989-996 (1991)PubMed: 1704006Koo H, Seils J, Abranches J, Burne RA, Bowen WH, Quivey RG.Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.Antimicrob Agents Chemother. 2006 Feb;50(2):542-6.PMID: 16436708Biswas S, Biswas I.Regulation of the glucosyltransferase (gtfBC) operon by CovR in Streptococcus mutans.J Bacteriol. 2006 Feb;188(3):988-98.PMID: 16428403Chen PM, Chen JY, Chia JS.Differential regulation of Streptococcus mutans gtfBCD genes in response to copper ions.Arch Microbiol. 2006 Mar;185(2):127-35.PMID: 16395551","Tue Apr 24 13:01:53 2007","Tue Apr 24 13:26:33 2007","1","","","SMU.1005","" "SMu0916","960370","961122","753","ATGTTTTTAGAAATCAATCACTTAGAAAAAGTTTTTCGTACCCGTTTTTCAAAAGAAGAGACGCATGCCTTGCAAGACGTTGACTTCAAAGTGGACAAGGGAGAATTTATCGCTATTATGGGAGAATCAGGTTCTGGCAAGACAACTTTACTTAACATTTTAGCGACTTTAGAAAAGCCGACAAATGGGGCAGTTATTCTAAATGGCCAAGACATCACCAAAATCAGAGAAAACAATTTAGCAAAATTTCGTCTTAAAAACTTAGGCTTTGTCTTTCAAGAGTTTAATTTGTTGGATACACTTTCTGTCAAAGATAATATCTTTTTACCTTTAGTGCTTGCTCGTAAAGACTATAAGGAGATGGAAAAACATTTGTATCGCCTTGCTCCGAAATTACGGATTCAAAATTTATTAGAAAAGCGTCCCTTTGAACTTTCTGGTGGTCAAAAACAACGTGTTGCTATTGCTCGCAGTCTGATTACCAATCCGCAAATCCTTTTAGCAGATGAACCAACAGCAGCACTTGATTATCGTAATTCAGAAGACTTATTGAATTTATTTGAAGCTATTAACAATGATGACCAAACGATTCTGATGGTCACCCACTCAGCTAATGCTGCTAGTCATGCTAAACGTGTTCTTTTTATCAAAGATGGACGGATATTTCACCAACTCTATAGAGGAAATAAAAGCAATCAAGAATTTAGCAAAGAAATTTCTCTAAGTATGGCAGCGCTGTTAGGAGGTGAGTAA","9.50","3.46","28386","MFLEINHLEKVFRTRFSKEETHALQDVDFKVDKGEFIAIMGESGSGKTTLLNILATLEKPTNGAVILNGQDITKIRENNLAKFRLKNLGFVFQEFNLLDTLSVKDNIFLPLVLARKDYKEMEKHLYRLAPKLRIQNLLEKRPFELSGGQKQRVAIARSLITNPQILLADEPTAALDYRNSEDLLNLFEAINNDDQTILMVTHSANAASHAKRVLFIKDGRIFHQLYRGNKSNQEFSKEISLSMAALLGGE","961130","For other components see SMu0917 (MSD1 and MSD2).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to a previously published protein:residues 2-246 are 50% similar to the protein in S.mutans (gi|9802355|). Residues 1-248 are 69% similar to the protein in Lactococcus lactis subsp. lactis (gi|15673732|). Residues 3-246 are 57% similar to the protein from S.pneumoniae (gi|15900793|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0974 (1e-119).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[144-186]T$	ABC_transporter
PF00005	$\"[34-219]T$	ABC_tran
PS00211	$\"[145-159]T$	ABC_TRANSPORTER_1
PS50893	$\"[6-243]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[33-220]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-222]T$	G3DSA:3.40.50.300
PTHR19222	$\"[3-246]T$	PTHR19222
PTHR19222:SF32	$\"[3-246]T$	PTHR19222:SF32
SSF52540	$\"[3-224]T$	SSF52540

","BeTs to 14 clades of COG1136COG name: ABC-type (unclassified) transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1136 is AMt--QVCEBRHUJGPOLinxNumber of proteins in this genome belonging to this COG is 8","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.4e-43. IPB001140A 23-69 IPB001140B 142-180 IPB001140C 196-225","Residues 194-249 are 46% similar to a (PROTEOME ATP-BINDING COMPLETE ABC) protein domain (PD048511) which is seen in O06980_BACSU.Residues 127-218 are 34% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in YN26_MYCTU.Residues 190-242 are 73% similar to a (ATP-BINDING ABC TRANSPORTER COMPLETE) protein domain (PD346883) which is seen in Q9CET4_LACLA.Residues 78-116 are 66% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230) which is seen in Q9K9E9_BACHD.Residues 24-73 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CET4_LACLA.Residues 144-186 are 79% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CET4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 10:37:32 2002","Wed Jan 9 11:11:28 2002","Tue Oct 29 10:37:32 2002","Wed Jan 9 11:11:28 2002","Wed Jan 9 11:11:28 2002","Wed Jan 9 11:11:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0916 is paralogously related (blast p-value < 1e-3) to SMu0786, SMu1288, SMu1246, SMu1231, SMu1068, SMu0731, SMu1751, SMu0218, SMu0517, SMu1380, SMu1210, SMu0594, SMu0971, SMu0849, SMu1001, SMu1949, SMu1003, SMu1762, SMu0884, SMu1920, SMu0234, SMu0418, SMu1079, SMu0475, SMu0390, SMu1023, SMu1757, SMu1950, SMu0805, SMu1316, SMu1710, SMu0258, SMu1064, SMu0335, SMu0235, SMu0824, SMu1428, SMu0976, SMu0825, SMu1518, SMu1517, SMu0907, SMu1410, SMu1036, SMu0836, SMu0216, SMu1037, SMu0987, SMu0476, SMu0596, SMu1724, SMu0374, SMu1065, SMu1811, SMu0752, SMu1545, SMu0950, SMu0944, SMu0986, SMu1649, SMu0024, SMu1093, SMu0666, SMu0837, SMu1306, SMu1959, SMu0729, SMu0164, SMu0823, SMu0224, SMu1050, SMu1202, and SMu1686, all with ATP binding capabilities.","Tue Jan 29 07:56:46 2002","Wed Jan 9 11:11:28 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 125 5e-030pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 112 5e-026","SMU.1006","","Residues 34 to 219 (E-value = 2.1e-61) place SMu0916 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Jan 9 11:11:28 2002","24379446","","","","Tue Oct 29 10:37:32 2002","","1","","","SMU.1006","673" "SMu0917","961124","963127","2004","ATGTTCTATCTTAAACTTGCTCTTAATAATATTAAGCAGTCTTTTAAACATTTCACCCCTTTTTTTCTAGTCAGTGTGACAACTTTTATTTTTAGTACTATTACGGTACTCCTTATGACTAGTCCATCCGCTAAGTCTATGGGGGCAGGAGTTTATGCTCTAGGTTTGGCTACCATAGTACTTGATATCTTAGCAGCTATTCTTTGTTTGTATAGTTACAATTTCCTTCTTAAACAGCGTAATAAAGAGTTTGGTCTGTATAATATTTTAGGAATGAATAAGAAGCATATCATTTGGGTATCAACATTAGAGCTGATAGTTGCTTATTTAGTGACAATTATCCTAGGAACCTTTCTCAGTGCAGTTCTCTCAAATTTTTTCTACTTGATTTTTGTCAATATTATTCAGTATGAAGATCTAAATTTTCAATTAACACTACCAGCTTTTGTGATTAATCTTATTCTTTTTGCTGTCATCTTCTTATTTTTAGAACTAGTTAATATTATAAAGATCAGCAAAACATCAGCTCTTAATCTCTTTAGCAATCAAAGTCAAGGAGAACGTGAGCCAAGAGGAAATATTGTTTTAGCTTTTATTGCTATCTTAGCGATTGGTTATGGTTATTATTTATCTGTCACCTCTGGTAATGTTAATGCTATATTTGGTATTACACGCTTTTTCCAGGCTATTTTAGCAGTTATTTTAGGAACTTATCTCTTTTACATTAGTTTTACTACTTGGTATTTGAAACGTCGTCGTAAGAACAAATCTTATTTTTATCAACCAGAGCATTTTGTAACAACTTCGCAGATGATTTTTCGTATGAAGCAAAATGCTGTCGGTTTAGCTAACATTACTCTGCTAGCCATTATGGCTTTTGTAACTATATTTTCAACAGTGGCGCTCTATACAAGTAGTGAAAATATGGTTAAAATGGCTTATCCCAAAAATGCTCAGATTGAGATGAAACATATCAGTAATCGTCAACAGGCTGAGGAAATTTTTCAAAAGCAGGTCTTAGCACCGCTCAAAAGAGCCGGCTATAATAGTAAGGCAAAATTTTCAGCTTACCTTGATATCAGCTATCCTGTTCTTTTTACACAAAAGCAAAATTTAGTTCTTGATAAGTCTATTGCAACTAATAGAACATTCTATAAAAACAATCATGCTGGTACAATGGAAATCATAACGCAAGATGATTTCCGGTCTATAGGTAATAAAGTCCCTCAATTATCAGCAGGAGAAGTGGCCTTTTACAGTTATAGCCAAAATACCACTGTTAAACCCTTTAAAACTTTAACTTGGTTTGGTCAAACTTATAAGAATGTTTATCATATAAAATCTATTAAAAATATGGTGATTAGCAACTCAGCAACACCTGCGGGTATTCTCGTTGTTCCTGACGATGCAACTATGGAAGCTATGCGTAAACCTTATGATGATGCATCAAAATATGATTATACCTATACATTTTTAGCTTTTGCTAATCTAACAAATAAAGAAAAACAGGTTTTAAATAGAATGAGTCAGGCTAAGCATGGACTTCTCTATGGCGATGATGATATAGCTGTTCTTTACTCAACTGCTGCGAATTATCGTACTGAAGGGTTGAGAATGACTGGCGGTTTCCTCTTTACAGGATTTCTATTGGGAATTGCCTTCTTACTTGGTGCTGCTTTAATTATATATTATAAACAGCTTTCAGAAGGAACACAAGATAAGCGATCTTATAAAATTTTACAAGAAGTGGGGATGAGCTTAAAACAAATTAAAAAAACAATCAACTCGCAAATTATCCTAGTTTTCTTCCTGCCTTTACTTATGGCTATCGTACATTTTGTTTTTGCTTTGCCTATTCTTAAAAAGCTGCTCTTCCTGTTTGGTGTACAAGGTGATAAATTCCTTTATACTGTTAGCGCTCTAACTGTAGTTGGAATCTTGATTATTTATTTCATTATTTACAAGTTAACGAGCAGAACTTACTATAAAATTATTGAAAGATAA","10.50","31.88","75817","MFYLKLALNNIKQSFKHFTPFFLVSVTTFIFSTITVLLMTSPSAKSMGAGVYALGLATIVLDILAAILCLYSYNFLLKQRNKEFGLYNILGMNKKHIIWVSTLELIVAYLVTIILGTFLSAVLSNFFYLIFVNIIQYEDLNFQLTLPAFVINLILFAVIFLFLELVNIIKISKTSALNLFSNQSQGEREPRGNIVLAFIAILAIGYGYYLSVTSGNVNAIFGITRFFQAILAVILGTYLFYISFTTWYLKRRRKNKSYFYQPEHFVTTSQMIFRMKQNAVGLANITLLAIMAFVTIFSTVALYTSSENMVKMAYPKNAQIEMKHISNRQQAEEIFQKQVLAPLKRAGYNSKAKFSAYLDISYPVLFTQKQNLVLDKSIATNRTFYKNNHAGTMEIITQDDFRSIGNKVPQLSAGEVAFYSYSQNTTVKPFKTLTWFGQTYKNVYHIKSIKNMVISNSATPAGILVVPDDATMEAMRKPYDDASKYDYTYTFLAFANLTNKEKQVLNRMSQAKHGLLYGDDDIAVLYSTAANYRTEGLRMTGGFLFTGFLLGIAFLLGAALIIYYKQLSEGTQDKRSYKILQEVGMSLKQIKKTINSQIILVFFLPLLMAIVHFVFALPILKKLLFLFGVQGDKFLYTVSALTVVGILIIYFIIYKLTSRTYYKIIER","963135","For other components see SMu0916 (NBD1) and SMu0917 (MSD2).","ABC transporter permease","Membrane, Cytoplasm","Matches in gapped BLAST to previously published protein in S.mutans:residues 1-667 are 23% similar to ABC transporter permease and permease OrfY (gi|9802356|).Residues 1-667 are 36% similar to gi|15673731| from L.lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0975 (1e-144).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-37]?$	signal-peptide
tmhmm	$\"[21-41]?$ $\"[55-75]?$ $\"[96-130]?$ $\"[149-169]?$ $\"[190-210]?$ $\"[229-249]?$ $\"[280-302]?$ $\"[542-564]?$ $\"[598-620]?$ $\"[634-654]?$	transmembrane_regions

","BeTs to 4 clades of COG0577COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0577 is AMt--QVcEBRHuj--OLinxNumber of proteins in this genome belonging to this COG is 7","No significant hits to the Blocks database.","Residues 563-661 are 52% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD025514) which is seen in Q9CET5_LACLA.Residues 70-311 are 45% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD187482) which is seen in Q9CET5_LACLA.Residues 1-68 are 42% similar to a (PROTEOME BINDING COMPLETE SUBSTRATE) protein domain (PD388496) which is seen in Q9CET5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 10:42:48 2002","Mon Oct 28 10:42:48 2002","Tue Oct 15 09:45:31 2002","Wed Jan 9 12:43:58 2002","","Wed Jan 9 12:43:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0917 is paralogously related (blast p-value < 1e-3) to SMu1414,a predicted conserved hypothetical protein; SMu1288,a predicted ABC transporter membrane protein subunit; and SMu1752, a predicted protein secretion ABC transport permease.","Tue Jan 29 08:42:12 2002","","No significant hits to the NCBI PDB database.","SMU.1007","","No significant hits to the Pfam 11.0 database","Wed Jan 9 12:43:58 2002","24379447","","","","Mon Oct 28 10:42:48 2002","","1","","","SMU.1007","674" "SMu0918","963169","963840","672","ATGCTAAAGCAAGAAAAAATTTACTTGGTTGAAGATGATACAACCATTGTCAATCTTTTAAAGAATCATTTGGGACAACACTATCAAGTTAAAAGCGTTGATAACTTTAGGGCTATCTTGCAAGAAGTTAAAGAATTTAAACCCGATTTAATTCTGATGGATATTACTTTGCCCTATTTCAATGGCTTTTATTGGACTACTGAAATCAGAAAGAGCATGACCATGCCCATTATCTTTATTTCCAGTGCTGATGAAGAAATGAATGCAGTAATGGCTATGAATATGGGAGGTGATGATTTTTTGAGCAAGCCTTTCTCGCTGCCTATTTTGGATGCCAAAATCGCTGCTTTCTTGCGCCGTGCTAACGAGTTCACTAAGCAAGGCCATCAAATTGAAGAGTTTGAATTAACGTTAGATGGTGTATTCTCAAATTTAGAAAGACAAGAGACTATCCAATTGACTCCAACAGAAACGAAAATTCTTTCCTTACTTATTGATTATAAAGGAGAGGTTGTCACTAAGGAAGCTCTTCTCAACCGACTATGGGAGGGAGAGGAATTTATTGATCAAAACACGCTTAGTGTTAATATGACACGTCTTCGTAAAAAGGTTCTATCAGTAAGTTTTGATAAGATTCATACAGTAAGAGGAGTAGGGTATTTAATTAAATGA","5.30","-5.02","25788","MLKQEKIYLVEDDTTIVNLLKNHLGQHYQVKSVDNFRAILQEVKEFKPDLILMDITLPYFNGFYWTTEIRKSMTMPIIFISSADEEMNAVMAMNMGGDDFLSKPFSLPILDAKIAAFLRRANEFTKQGHQIEEFELTLDGVFSNLERQETIQLTPTETKILSLLIDYKGEVVTKEALLNRLWEGEEFIDQNTLSVNMTRLRKKVLSVSFDKIHTVRGVGYLIK","963848","For other 'llr' genes see SMu0841 (llrF).","response regulator","Cytoplasm","Matches in gapped BLAST to previously published protein from S.mutans (gi|14600271|):residues 5-223 are 32% similar to responder protein CovR (gi|14600271|).Residues 6-222 are 53% similar to two-component system regulator from L.lactis (gi|15673729|). Residues 6-223 are 40% similar to gi|15893516| from Clostridium acetobutylicum. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0976 (1e-76).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[6-119]T$	Response_reg
PF00072	$\"[5-115]T$	Response_reg
SM00448	$\"[5-114]T$	REC
PS50110	$\"[6-118]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[149-220]T$	Trans_reg_C
PF00486	$\"[148-222]T$	Trans_reg_C

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[3-129]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[6-154]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[3-120]T$	PTHR23283
PTHR23283:SF21	$\"[3-120]T$	PTHR23283:SF21
SSF46894	$\"[123-222]T$	SSF46894

","BeTs to 9 clades of COG0745COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG0745 is -----QVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 10","***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 1.2e-40. IPB001867A 49-62 IPB001867B 76-120 IPB001867C 151-182 IPB001867D 208-222***** IPB001789 (Response regulator receiver domain) with a combined E-value of 1.7e-08. IPB001789A 8-14 IPB001789B 49-62 IPB001789C 96-105","Residues 6-119 are 60% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in Q9CET7_LACLA.Residues 148-222 are 57% similar to a (DNA-BINDING TRANSDUCTION SENSORY TRANSCRIPTION) protein domain (PD000329) which is seen in Q9CET7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 10:55:29 2002","Tue Jan 8 11:47:48 2002","Tue Oct 15 09:46:21 2002","Wed Jan 9 13:06:13 2002","Tue Jan 8 11:47:48 2002","Tue Jan 8 11:47:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0918 is paralogously related (blast p-value < 1e-3) to SMu1379, SMu1653, SMu1032, SMu0601, SMu1748, SMu1048, SMu0947, SMu0841, SMu1782, and SMu0441, all predicted response regulators.","Tue Jan 29 08:50:04 2002","Tue Jan 8 11:47:48 2002","pdb|1B00|A Chain A, Phob Receiver Domain From Escherichia Coli ... 63 3e-011","SMU.1008","","Residues 5 to 122 (E-value = 1.1e-23) place SMu0918 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 148 to 222 (E-value = 1.5e-21) place SMu0918 in the Trans_reg_C family which is described as Transcriptional regulatory protein, C terminal (PF00486)","Tue Jan 8 11:47:48 2002","24379448","","","","Tue Apr 2 14:53:52 2002","","1","","","SMU.1008","799" "SMu0919","963837","964790","954","ATGATAAGATCTTATTTGAGAGAATATAGTATTTGGTATTTAAATTATGCGATTGTTAGTCTTGCTTTTTTACTGACTTTTTATCTTTATCATCTGCCTCTCGTCTATTTTATCAATAGTTTAATCCTCAGTTTAACAATTTTACTGATAACTAGTCTCATTTTATACTGGCGGTTCCACCAAAAATTAAAAAATTTGCATCATTTTATTTATGTAAAAGAACCAAGGAATTTAACTATGTTAACTGCACCAAGTGATCTTGTTTATAAAGAAATTCTTAAAAAACTGCTGCAGGAACAGTCTGACATTAATTTACAGCATAAAACGCAGGAAGAACAGCTGCAGCAGCTGATTAAATTGTGGTCCCATCAGATGAAAGTTCCTATTTCAGCACTATCTTTAATGGCTCAAACGGGGCATTTAGATAAAGAAGATGTTCAGAGACAATTGTTAAGGTTAGAAAACGATCTTTCTCGTCTTTTGAACTACCTTAAGTTCAGTCAAAATCAAAGCGATTTTCGTTTTGAAAAGTGTCAGATTCGTAATATTCTGATTGATTTGATTAAGAAAAATCAAGTTTTCTTCTTGCAAAAGGACCTTTCTTTGACAATTGATGGCGATTGGGAAATAAAATCCGATAAAAAATGGTTAAGTTTTGTCTTTTCTCAAATTCTTGATAATGCCATTAAATATAATAAAAAGGGTGGGCAGATCACCATTAAGATTAAGGAAAATCAAATACTTATCAGGGATACTGGCATAGGAATTCTAAAGGAAGATATTCCCAGACTTTTTGAAGAAGGCTTTACAGGATATAATGGTCATGAACACCAAAAAGCCACTGGTCTTGGTCTTTATATGGCTAAAAAGGTGCTTAATAATCTTGAGTTAGATATTAATATCGAAAGTCAGATTGATCAAGGAACACAGGTTTATGTTACTAAAAGAAGGTAA","10.10","10.13","37512","MIRSYLREYSIWYLNYAIVSLAFLLTFYLYHLPLVYFINSLILSLTILLITSLILYWRFHQKLKNLHHFIYVKEPRNLTMLTAPSDLVYKEILKKLLQEQSDINLQHKTQEEQLQQLIKLWSHQMKVPISALSLMAQTGHLDKEDVQRQLLRLENDLSRLLNYLKFSQNQSDFRFEKCQIRNILIDLIKKNQVFFLQKDLSLTIDGDWEIKSDKKWLSFVFSQILDNAIKYNKKGGQITIKIKENQILIRDTGIGILKEDIPRLFEEGFTGYNGHEHQKATGLGLYMAKKVLNNLELDINIESQIDQGTQVYVTKRR","964798","For other 'kin' genes see SMu0842 (kinF) and SMu1031 (kinF).","sensor histidine kinase","Cytoplasm, Membrane","Weakly matches in gapped BLAST to a previously published sequence from S.mutans:residues 209-309 are 33% similar to sensor protein CovS (gi14600272). Residues 16-315 are 38% similar to the protein in Lactococcus lactis subsp.lactis (gi15673728).Residues 92-313 are 35% similar to the protein in S.pneumoniae (gi15901468). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0977 (1e-77).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[175-314]T$	ATP_bd_ATPase
PF02518	$\"[212-314]T$	HATPase_c
SM00387	$\"[212-317]T$	HATPase_c
SSF55874	$\"[158-314]T$	ATP_bd_ATPase

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[113-169]T$	HisKA
SM00388	$\"[113-172]T$	HisKA

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[120-317]T$	HIS_KIN

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[103-172]T$	His_kin_homodim

noIPR
unintegrated

unintegrated
PTHR23283	$\"[104-317]T$	PTHR23283
PTHR23283:SF26	$\"[104-317]T$	PTHR23283:SF26

","BeTs to 10 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 113-304 are 25% similar to a (KINASE PROTEOME COMPLETE TRANSFERASE) protein domain (PD113037) which is seen in O25917_HELPY.Residues 83-223 are 27% similar to a (KINASE PROTEOME COMPLETE TRANSFERASE) protein domain (PD108479) which is seen in Q9KG42_BACHD.Residues 220-266 are 49% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD371767) which is seen in Q9S1J9_STRPN.Residues 200-313 are 57% similar to a (KINASE TRANSDUCTION TRANSFERASE SENSORY) protein domain (PD036888) which is seen in Q9CET8_LACLA.Residues 16-199 are 26% similar to a (KINASE PROTEOME COMPLETE SENSOR) protein domain (PD399435) which is seen in Q9CET8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 09:20:54 2006","Thu Sep 14 09:20:54 2006","Thu Sep 14 09:20:54 2006","Wed Jan 9 13:29:15 2002","","Tue Jan 8 11:48:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0919 is paralogously related (blast p-value < 1e-3) to SMu0602, SMu0946, SMu1031, and SMu1378, all predicted histidine kinases.","Tue Jan 29 08:53:48 2002","","No significant hits to the NCBI PDB database.","SMU.1009","","Residues 212 to 317 (E-value = 3.4e-23) place SMu0919 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Tue Jan 8 11:48:56 2002","24379449","",""," Lange,R., Wagner,C., de Saizieu,A., Flint,N., Molnos,J.,Stieger,M., Caspers,P., Kamber,M., Keck,W. and Amrein,K.E.Domain organization and molecular characterization of 13two-component systems identified by genome sequencing ofStreptococcus pneumoniaeGene 237 (1), 223-234 (1999)PubMed: 10524254","","Wed Jan 9 13:34:32 2002","1","","","SMU.1009","929" "SMu0920","965990","964941","1050","ATGTCAACTTCTCATCCCATTTCAAAAATTTATTTTTCTGATAAAAAAAGCCTTCAAAAAGTTGATATTTTATTAGAACAAGAAGGCATACGCCGTGATACTAACTTAGATTATATTTGTGCCATGTTTGATGATGACTTAAATATCATTGCGACAGGAAGTTGTTTTGGCAATACTCTTCGTTGTTTAAGTGTAGATCATCATTATCAAGGTGATGGTTTGCTTAATGAAATTGTCACGCATTTAATTAATATTCAATTTGAACGTGGCAATACACATCTTTTTCTTTATACTAAACCTGATACTGCAAAATTCTTTAAAGACTTGGGTTTTTACGAAATTGCCAGAGCCGATAAGCAAATTGTTTTTATGGAAAATAAAAAAGATGGTTTTAGTAATTATTTAAAAAATCTTGAAAAACCTGATAGCGAGTGCCAAACTACTGCTGCTCTCGTTATCAACGCCAATCCTTTTACTTTAGGCCATCAGTATTTGGTTGAAAAAGCCGCTGCTGAAAATGAACTCTTGCATCTTTTTATGGTCAGCGACGATAGTAGCCTCATCCCTTTTTCAGTTAGAAAACAATTGATTTTAGCTGGAACAGAGCATCTATCAAATATTTGCTATCATGAAACGGGTCCTTATATCATCAGCAAATCAATCTTTCCTAGCTATTTTCAAAAAGATCAGGCATCAGTCATTGAAAGTCAGGCACGCATTGATCTAGCTATTTTCATTCAAATTGCAAAATACCTTGGTATCAAAGGGCGTTATGTCGGTGAGGAACCAACAAGTCTGGTGACTGGTATTTATAATCAAATCATGCTTCAAGAGCTGCCTAAGCAAGCTATTGATTGCATAGTTGTTCCTCGTAAGACCTACAAAGACGGTCCTATTAGTGCTTCTACTGTCCGCAAGGCGCTTAAAGAAGGAAATGAGCAAATCTTAAGAGAACTGCTTCCATCAACAAGTTTGAATTATTTCCTAAGTCCTGAAGCACAGCCGCTTATTAAAAAAATTCAAAAAGCAGATAATGTCATTCATTATTAA","6.50","-2.86","39529","MSTSHPISKIYFSDKKSLQKVDILLEQEGIRRDTNLDYICAMFDDDLNIIATGSCFGNTLRCLSVDHHYQGDGLLNEIVTHLINIQFERGNTHLFLYTKPDTAKFFKDLGFYEIARADKQIVFMENKKDGFSNYLKNLEKPDSECQTTAALVINANPFTLGHQYLVEKAAAENELLHLFMVSDDSSLIPFSVRKQLILAGTEHLSNICYHETGPYIISKSIFPSYFQKDQASVIESQARIDLAIFIQIAKYLGIKGRYVGEEPTSLVTGIYNQIMLQELPKQAIDCIVVPRKTYKDGPISASTVRKALKEGNEQILRELLPSTSLNYFLSPEAQPLIKKIQKADNVIHY","964955","For other 'cit' genes see SMu0612 (citB);SMu0613 (citZ); SMu0614 (citC); SMu0921 (citG);SMu0929 (citD); SMu0930 (citE); SMu0931 (citF) and SMu0932 (citX2). From Genbank:[gi:1168960]This protein is involved in the acetylation of prosthetic group (2-(5''-PHOSPHORIBOSYL)-3'-DEPHOSPHOCOENZYME-A) of the gamma subunit of citrate lyase.","citrate lyase synthetase","Cytoplasm","Several matches in gapped BLAST to citrate lyase synthetase: residues 5-349 are 57% similar to the enzyme in S.pyogenes (gi|15675161|). Residues 13-327 are 38% similar to the protein from Haemophilus influenzae Rd (gi|16272000|).SMu0920 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PS51186	$\"[1-129]T$	GNAT

InterPro
IPR004821
Domain

Cytidyltransferase-related
TIGR00125	$\"[148-206]T$	cyt_tran_rel

InterPro
IPR005216
Family

Citrate lyase ligase
PIRSF005751	$\"[6-347]T$	Acet_citr_lig
TIGR00124	$\"[7-337]T$	cit_ly_ligase

InterPro
IPR013166
Domain

Citrate lyase ligase, C-terminal
PF08218	$\"[148-328]T$	Citrate_ly_lig
SM00764	$\"[148-328]T$	Citrate_ly_lig

noIPR
unintegrated

unintegrated
SSF52374	$\"[147-333]T$	SSF52374
SSF55729	$\"[1-138]T$	SSF55729

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 13-327 are 38% similar to a (LIGASE LYASE CITRATE PRO-3S-LYASE) protein domain (PD016147) which is seen in CITC_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 10:06:03 2002","Wed Jan 9 13:41:13 2002","Tue Oct 15 09:52:00 2002","Wed Jan 9 13:40:25 2002","","Wed Jan 9 13:40:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0920 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 13:41:13 2002","","No significant hits to the NCBI PDB database.","SMU.1010c","","No significant hits to the Pfam 11.0 database","Wed Jan 9 13:40:25 2002","","","","Ingmer,H., Miller,C.A. and Cohen,S.N.Destabilized inheritance of pSC101 and other Escherichia coliplasmids by DpiA, a novel two-component system regulatorMol. Microbiol. 29 (1), 49-59 (1998)PubMed: 9701802Bowien S, Gottschalk G.Purification and properties of citrate lyase ligase from Streptococcus diacetilactis.Eur J Biochem. 1977 Oct 17;80(1):305-11.PMID: 923578 ","","Wed Jan 9 13:45:46 2002","1","","","SMU.1010c","" "SMu0921","967056","966166","891","ATGCAGACTAAAGAAAAGCTTGCTTCTTTGAGCTATTTAGCAGTCAAATCACTGCTTTATGAATTGAATCTAACACCTAAACCTGGTTTAGTAGATTGTCATAATAACGGCGCTCACAATGACATGGATTTTTATACCTTTCTTGATAGTATATTATCCTTATCTCCGTTTTTTAAAAAATATATTGAAGTAGGGTGGCTCTATCATAATGAAAGTCCACAATATTTGTTTAATCAACTCAGAAAACTTGGCATAGAAGCTGAGGCTGCTATGTTTTCTGCAACTGAGAGAGTCAATACTCATAAAGGCATTAATTTCTCTTTTGCTCTGCTTTTAGGAGCAACCGGCAGTTATTTGGCTAAACACATTGAACTGATCCAAGAAAAAAGACGCTTTATGCCTCAAGATAGTCTGACTATCTGTCATTTGGCAGGGGAAATGAGTATGCATTTAATTCAAAATGATTTAAGCCATGTGGAGACTAAAAGAAACCTTACATATGGTGAGAAATTATTTTTACAATATGGTCTTAAAGGCCTTAGAGGTGAGGCATCCCAAGGTTATCCAAGCCTTACTCAAAAAGCCCTTCCTTTTTTTAGAAATGAATTACTGAAAAAACAGGATATCCAAATAAGCCAGCTTAAGCTCTTGCTCTATCTGATGACGTTTATTGAAGACAGCAATATTATTCATCGAGGGGGTATTAAGTCTTGGAAAAAAGTCCAACAAGAAGCTCAAACTTTATTAGAAAAAGATTTACCTCCTTATCAACTAAAAGAACAGCTTAATTCTTACAATCAAATATTAACTGATCGTCATTTAAGTCCCGGCGGTGCTGCTGATTTACTCTCACTAACACTTTATTTTTCCTTTTTAGAACAGCTGATTTAA","8.20","3.32","33928","MQTKEKLASLSYLAVKSLLYELNLTPKPGLVDCHNNGAHNDMDFYTFLDSILSLSPFFKKYIEVGWLYHNESPQYLFNQLRKLGIEAEAAMFSATERVNTHKGINFSFALLLGATGSYLAKHIELIQEKRRFMPQDSLTICHLAGEMSMHLIQNDLSHVETKRNLTYGEKLFLQYGLKGLRGEASQGYPSLTQKALPFFRNELLKKQDIQISQLKLLLYLMTFIEDSNIIHRGGIKSWKKVQQEAQTLLEKDLPPYQLKEQLNSYNQILTDRHLSPGGAADLLSLTLYFSFLEQLI","966180","For other 'cit' genes see SMu0612 (citB);SMu0613 (citZ); SMu0614 (citC); SMu0920 (citC);SMu0929 (citD); SMu0930 (citE); SMu0931 (citF) and SMu0932 (citX2). From Genbank:[gi:2498242]This enzyme catalyzes the formation of 2-(5''-TRIPHOSPHORIBOSYL)-3'-DEPHOSPHOCOENZYME-A,the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase from ATP and dephospho-CoA . ","citG protein","Cytoplasm","Several matches in gapped BLAST to citG protein: residues 3-296 are 56% similar to the protein in S.pyogenes (gi|15675150|).Residues 10-295 are 37% similar to the protein from Vibrio cholerae (gi|15640819|).SMu0921 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002736
Family

Triphosphoribosyl-dephospho-CoA protein
PF01874	$\"[16-287]T$	CitG

","No hits to the COGs database.","***** IPB002736 (CitG family) with a combined E-value of 1.6e-41. IPB002736A 24-41 IPB002736B 81-113 IPB002736C 208-249 IPB002736D 272-289","Residues 10-286 are 37% similar to a (PROTEOME MDCB COMPLETE MADG) protein domain (PD009887) which is seen in Q9KTT7_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 10:05:41 2002","Wed Jan 9 13:50:15 2002","Tue Oct 15 09:53:07 2002","Wed Jan 9 13:49:04 2002","Wed Jan 9 13:49:04 2002","Wed Jan 9 13:49:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0921 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 13:49:38 2002","","No significant hits to the NCBI PDB database.","SMU.1011c","","Residues 16 to 287 (E-value = 1.8e-62) place SMu0921 in the CitG family which is described as ATP:dephospho-CoA triphosphoribosyl transferase (PF01874)","Wed Jan 9 13:49:04 2002","","","","Bott,M. and Dimroth,P.Klebsiella pneumoniae genes for citrate lyase and citrate lyaseligase: localization, sequencing, and expressionMol. Microbiol. 14 (2), 347-356 (1994)PubMed: 7830578Schneider,K., Dimroth,P. and Bott,M.Identification of triphosphoribosyl-dephospho-CoA as precursor ofthe citrate lyase prosthetic groupFEBS Lett. 483 (2-3), 165-168 (2000)PubMed: 11042274Schneider,K., Dimroth,P. and Bott,M.Biosynthesis of the prosthetic group of citrate lyaseBiochemistry 39 (31), 9438-9450 (2000)PubMed: 10924139","","Wed Jan 9 13:53:50 2002","1","","","SMU.1011c","" "SMu0922","967751","967062","690","ATGAACGCATCAGTTATAACTGCTGTAAAAAATAATTTAGATTTATCACAAAATGTTCCTTTAAAAGTTGCTTTTTATGAAGCTTTAAGGAAGACCATCATTCTTAGTGAAATTCCAGCAGGCTGTCGCATTAACGAAAAAGAACTTGCTTCTGCTCTTAATATTAGTCGGACACCTATCCGCTATGCACTGGGGGTTTTAGAAGAAGAAAAACTTGTTGAACATATTCCCAAACGCGGCATTATTGTTCGTGGCATTTCTTTAAAAGATGCTATTGAAATTTTTGATATCCGAAAGGCTTTAGACACTCTGGCAGCTACCAAGGCAATGTATTTAATGACTGATAAAGATTTTGCAGATATGAAAAAAATTCTAACTGACTGTGAAGATTTTATTGAAGATGGTGATATCGAAACTATTTTAGATAATTTCAATCAATTTAACGATCTGATTTATCGAAAAAGTCAAATGTTGCGCCTACGAGAGATCGTTACCGAATTACAGACTTATTTGAGATATTTTCGAGAAATATCAATTGCTTCTGTAGAACGGCGTAAGCGAGCTTTGAAAGAACATTGGATTATCTATCGTGGTATGCGCAATAAGGATGTCGAGCAAATTACTCTTATCACCCATGAGCACTTGAATGCTTCTCTTGACTTTATTCTTCAACAAATGGAAAGTAAGTAA","6.90","-0.12","26576","MNASVITAVKNNLDLSQNVPLKVAFYEALRKTIILSEIPAGCRINEKELASALNISRTPIRYALGVLEEEKLVEHIPKRGIIVRGISLKDAIEIFDIRKALDTLAATKAMYLMTDKDFADMKKILTDCEDFIEDGDIETILDNFNQFNDLIYRKSQMLRLREIVTELQTYLRYFREISIASVERRKRALKEHWIIYRGMRNKDVEQITLITHEHLNASLDFILQQMESK","967076","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator: residues 5-226 are 71% similar to the protein in S.pyogenes (gi|15675151|).Residues 11-227 are 25% similar to the protein from Bacillus subtilis (gi|16077637|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2073 (2e-04).","

InterPro
IPR000524
Domain

Bacterial regulatory protein GntR, HTH
PR00035	$\"[43-57]T$ $\"[57-73]T$	HTHGNTR
PF00392	$\"[21-83]T$	GntR
SM00345	$\"[25-83]T$	HTH_GNTR
PS50949	$\"[19-86]T$	HTH_GNTR

InterPro
IPR011711
Domain

GntR, C-terminal
PF07729	$\"[93-217]T$	FCD

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[14-86]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[18-90]T$	SSF46785

","BeTs to 4 clades of COG1802COG name: Transcriptional regulators, GntR familyFunctional Class: KThe phylogenetic pattern of COG1802 is ------v-EBR----------Number of proteins in this genome belonging to this COG is 1","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 1.6e-11. IPB000524 43-83","Residues 26-93 are 44% similar to a (TRANSCRIPTIONAL REGULATOR DNA-BINDING) protein domain (PD000726) which is seen in Q9ZFL9_BACST.Residues 39-97 are 40% similar to a (REGULATOR TRANSCRIPTIONAL REGULATION) protein domain (PD202348) which is seen in YTUX_AGRVI.Residues 98-206 are 27% similar to a (TRANSCRIPTION DNA-BINDING REGULATOR) protein domain (PD006178) which is seen in Q9HIE6_THEAC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 14:03:36 2002","Wed Jan 9 14:03:56 2002","Tue Oct 15 09:54:18 2002","Wed Jan 9 13:58:05 2002","Wed Jan 9 13:58:05 2002","Wed Jan 9 13:58:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0922 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 14:03:36 2002","","No significant hits to the NCBI PDB database.","SMU.1012c","","Residues 21 to 83 (E-value = 1.3e-11) place SMu0922 in the GntR family which is described as Bacterial regulatory proteins, gntR family (PF00392)","Wed Jan 9 13:58:05 2002","24379452","","","","","","1","","","SMU.1012c","" "SMu0923","969384","967981","1404","ATGTTGCTAACAATTCTAGCTTATGCTATGATTATTGTCTTCATGTACGTTGTTATGAAGAAGAAAATGTCGCCTTTTACGGCACTGATTATAGTTCCTTTAGTAGCTGTCATTATTGTTATCTTAACAAATTCTGCAAACTTTACAGCTGATAAAAGTTTCGTTGAATTTTTGGGAGGCGATAAAATTTCCCATAATTTAACAGCTATTGGACCTATGGTATTATATGGAATTAATAATACCGCTCAAACAGGAATTATGCTTCTATTTGCTATCTTATATTTCTCATTAATGCTGGATGCAGGGCTGTTCGATCCGATTACTGAAAAAATGATTCGCTTTGCTAAGGGCGATCCAATGAAAGTTTTGATAGCTACCGCTATCGTTTCCGCTGCTGTTTCTCTTAATGGCGACGGAACTACAACTACTCTTATTTGCTGTTCTGCCTTTCTGCCAATCTATAAAAAACTTAATATGAAAATTATGAATCTTGGTGTTTTGATTATTCTTCAAAATACTATTATGAACCTACTTCCTTGGGGCGGACCAACTGCTCGGGCTATGTCTGTTTTAAACGTTGGTTCTGAAATATTAGGCTATCTAGCACCCGGTATGATTTTATCCCTACTTTATGTTATCTTCTTCGTCGCTAGAAGCATGGGTAAAAAAGAACGCAAACGTTTAGGTGTTACTGAATTATCTGACAAAGAAATAACAGAATTAATCACTGTTAACGATCCTGATACACTTAAAATTCGTCGACCTCAAAATTTTTGGTTTAATGGTATTTTGACACTTATCTTAATTGCTTGGTTAGTTGCCGGTTCTTTCATTTCGGCTATTGAAATGCCTTCACTTCTTCTCTTTGCATTAGGAACTTGTATTGCTTTAATGGTCAACTACCCTAATTTGAAAGAACAATCAAAACGAATTAGTGAAAATGCTGGTGATGCTGTTCAAGTTGTTATCCTTGTCTTCGCTGCAGGTATCTTCATGGGACTTTTCCAAGGTTCTGGTATGGCTGGGGCTCTAGCACAAAGCTTTACAACTATCATTCCTAAACAACTGGCTGGTTTCTGGGGCTTAGTCATCGCCTTTATCTCTGCTCCTGGTACATTTTTCCTTTCAAATGATGGCTTTTATTATGGTATTATGCCAGTCTTGGCGGAAGCTGGTGCTAAATATGGATTTGATAATGTTGCTATGGCTTTAGCCTCATTGATGGGACAAGCTTTTCACTTATTAAGTCCATTAGTTGCCTTTATTTATCTACTTCTTCGCTTAACGGGCTTAGACATGGGCGAATGGCAAAGAGAGTCTGCTAAATATGCACTGGTTGTCTTTATCATCTTTGTGGTGACAATTCTTATCGTGGGACGTCTACCATTTTATATTCCACAATAA","9.70","6.34","50912","MLLTILAYAMIIVFMYVVMKKKMSPFTALIIVPLVAVIIVILTNSANFTADKSFVEFLGGDKISHNLTAIGPMVLYGINNTAQTGIMLLFAILYFSLMLDAGLFDPITEKMIRFAKGDPMKVLIATAIVSAAVSLNGDGTTTTLICCSAFLPIYKKLNMKIMNLGVLIILQNTIMNLLPWGGPTARAMSVLNVGSEILGYLAPGMILSLLYVIFFVARSMGKKERKRLGVTELSDKEITELITVNDPDTLKIRRPQNFWFNGILTLILIAWLVAGSFISAIEMPSLLLFALGTCIALMVNYPNLKEQSKRISENAGDAVQVVILVFAAGIFMGLFQGSGMAGALAQSFTTIIPKQLAGFWGLVIAFISAPGTFFLSNDGFYYGIMPVLAEAGAKYGFDNVAMALASLMGQAFHLLSPLVAFIYLLLRLTGLDMGEWQRESAKYALVVFIIFVVTILIVGRLPFYIPQ","967995","","Mg2+/citrate complex transporter","Membrane, Cytoplasm","Matches in gapped BLAST to Mg2+/citrate complex transporter:residues 1-467 are 78% similar to the protein in S.pyogenes (gi|15675152|).Residues 2-463 are 40% similar to the protein from B.subtilis (gi|16080957|)SMu0923 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003439
Domain

ABC transporter related
PS00211	$\"[114-128]?$	ABC_TRANSPORTER_1

InterPro
IPR004680
Family

Divalent ion symporter
PF03600	$\"[6-410]T$	CitMHS

InterPro
IPR014738
Family

Citrate transporter
TIGR00784	$\"[2-464]T$	citMHS

noIPR
unintegrated

unintegrated
PTHR10283	$\"[8-56]T$ $\"[83-459]T$	PTHR10283
PTHR10283:SF44	$\"[8-56]T$ $\"[83-459]T$	PTHR10283:SF44

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-334 are 41% similar to a (CITRATE TRANSPORT TRANSPORTER) protein domain (PD025147) which is seen in CITN_BACSU.Residues 337-464 are 41% similar to a (COMPLETE PROTEOME TRANSMEMBRANE TRANSPORT) protein domain (PD009429) which is seen in Q9HTA2_PSEAE.Residues 337-444 are 45% similar to a (TRANSPORT CITRATE TRANSMEMBRANE) protein domain (PD391296) which is seen in YRAO_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 14:19:26 2002","Wed Jan 9 14:19:26 2002","Tue Oct 15 09:56:27 2002","Wed Jan 9 14:18:29 2002","","Wed Jan 9 14:18:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0923 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 14:19:26 2002","","No significant hits to the NCBI PDB database.","SMU.1013c","","Residues 2 to 463 (E-value = 2.9e-259) place SMu0923 in the CitMHS family which is described as Citrate transporter (PF03600)","Wed Jan 9 14:18:29 2002","24379453","","","Boorsma,A., van der Rest,M.E., Lolkema,J.S. and Konings,W.N.Secondary transporters for citrate and the Mg(2+)-citrate complexin Bacillus subtilis are homologous proteinsJ. Bacteriol. 178 (21), 6216-6222 (1996)PubMed: 8892821","","Wed Jan 9 14:22:57 2002","1","","","SMU.1013c","" "SMu0924","969627","970007","381","ATGACTTTTTATTTGTTATTATTATATTATAAGATAAGAAAGGGGAAGAGTATGGGAATTTTTACGCGATTTTTCAATAAATTACAGGATCCTATTGAAAAAAACAACGATAGTAAAAAGGAAAAGGCTGCAAATTCTTTTCAATCTGAATGGGAGCCTATTTCGGCTTTTATTCCTGCAGATGAAGTCGATTATCAAACAGTCAGTCTTATCGCAACAGCTATTGCAGCTGAAGATCACCCAAATAGGCAATTTGTTGTCAAAAAAATTTTACAGCGCAATCCTGAAAGCTTAAGGGTTTCATTGATTGCTGCCAGTATTGCGGCTGGAGAATCAACGGATTGTCAGTTAACGGTTAAACGTATTTATAAAAAGAAATAA","10.30","6.18","14403","MTFYLLLLYYKIRKGKSMGIFTRFFNKLQDPIEKNNDSKKEKAANSFQSEWEPISAFIPADEVDYQTVSLIATAIAAEDHPNRQFVVKKILQRNPESLRVSLIAASIAAGESTDCQLTVKRIYKKK","970015","","hypothetical protein","Periplasm, Membrane","No significant hits in gapped BLAST found.SMu0924 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 14:24:58 2002","Wed Jan 9 14:24:58 2002","Wed Jan 9 14:24:58 2002","Wed Jan 9 14:24:58 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0924 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 14:24:58 2002","","No significant hits to the NCBI PDB database.","SMU.1014","","No significant hits to the Pfam 11.0 database","Wed Jan 9 14:24:58 2002","24379454","","","","","","1","","","SMU.1014","" "SMu0926","970026","970418","393","ATGTTGCGTAAATTTAAAATCTCGATTGATGGTAAAGAATACTTAGTTGAAATGGAGGAAATCAGTGAAAGTTCAGTACCAGCAGCTACCCCCATCACTCCTACAACAGAAAACACGAGGGCAGCATCAGATCAAAAACAACAGTCCCAGACACCATCACCAGCTGCAACAGCCTCTGCTGCTAATACGATGCCAGCTCCAATGCCTGGAACTATTTTAAAGGTTCTTGTTAATGTTGGTGACACTGTTTCTGAAAATCAACCTTTGATGATTCTAGAAGCGATGAAAATGGAAAATGAAATTGTTGCTGGCATGGCAGGTACTGTTTCTGCTATTCATGTTAGTTCGGGGCAGACGGTTAATGCTGGTGATAACTTAATTACAATTGCTTAA","4.20","-3.78","6875","MLRKFKISIDGKEYLVEMEEISESSVPAATPITPTTENTRAASDQKQQSQTPSPAATASAANTMPAPMPGTILKVLVNVGDTVSENQPLMILEAMKMENEIVAGMAGTVSAIHVSSGQTVNAGDNLITIA","970426","","biotin carboxyl carrier protein","Cytoplasm","Matches in gapped BLAST to biotin carboxyl carrier protein: residues 1-67 are 98% similar to the previously published protein in S.mutans (gi|114848|).Residues 1-66 are 77% similar to decarboxylase, gamma chain in S.pyogenes (gi|15675154|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0350 (2e-07).","

InterPro
IPR000089
Domain

Biotin/lipoyl attachment
PF00364	$\"[1-66]T$	Biotin_lipoyl
PS50968	$\"[1-66]T$	BIOTINYL_LIPOYL

InterPro
IPR001882
Binding_site

Biotin-binding site
PS00188	$\"[23-40]T$	BIOTIN

noIPR
unintegrated

unintegrated
G3DSA:2.40.50.100	$\"[1-67]T$	no description
PTHR18866	$\"[4-67]T$	CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE
PTHR18866:SF13	$\"[4-67]T$	PROPIONYL-COENZYME A CARBOXYLASE, ALPHA POLYPEPTIDE

","BeTs to 15 clades of COG0511COG name: Biotin carboxyl carrier protein of acetyl-CoA carboxylaseFunctional Class: IThe phylogenetic pattern of COG0511 is AmtKYQvceBRhuj---linxNumber of proteins in this genome belonging to this COG is 2","***** IPB001882 (Biotin-requiring enzymes attachment site) with a combined E-value of 1.1e-20. IPB001882H 4-49***** PR01071 (Acetyl-CoA biotin carboxyl carrier protein signature) with a combined E-value of 1.1e-08. PR01071B 13-27 PR01071C 28-41","Residues 5-66 are 98% similar to a (BIOTIN DIHYDROLIPOAMIDE LIPOYL CARBOXYLASE TRANSFERASE) protein domain (PD000268) which is seen in BCCP_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 9 14:28:45 2002","Wed Jan 9 14:27:26 2002","Tue Oct 15 09:58:29 2002","Wed Jan 9 14:27:26 2002","Wed Jan 9 14:27:26 2002","Wed Jan 9 14:27:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0926 is paralogously related (blast p-value < 1e-3) to SMu1584,a predicted biotin carboxyl carrier protein; and SMu1296, a predicted acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase).","Tue Jan 29 09:29:17 2002","Wed Jan 9 14:27:26 2002","pdb|1DCZ|A Chain A, Biotin Carboxyl Carrier Domain Of Transcarb... 61 2e-011","SMU.1016","","Residues 1 to 66 (E-value = 3.7e-29) place SMu0926 in the Biotin_lipoyl family which is described as Biotin-requiring enzyme (PF00364)","Wed Jan 9 14:27:26 2002","24379455","","Wang,D., Waye,M.M., Taricani,M., Buckingham,K. and Sandham,H.J.Biotin-containing protein as a cause of false positive clones ingene probing with streptavidin/biotinBioTechniques 14 (2), 209-212 (1993)PubMed: 8431283","Marini P, Li SJ, Gardiol D, Cronan JE Jr, de Mendoza D.The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis.J Bacteriol. 1995 Dec;177(23):7003-6.PMID: 7592499 ","Tue Jan 29 09:29:17 2002","Wed Jan 9 14:32:29 2002","1","","","SMU.1016","" "SMu0927","970441","971562","1122","GTGGAAACTTTAATTTCAGGAATAATATCCATTACTATCCCTCAAATAATTATGATGGTCATCGGGGCTGTTTTAATGTATTTAGGAATTAAAAAAGAATATGAACCAACCTTATTGATACCTATGGGACTTGGTACACTTTTAGTGAATTTTCCCGGTACAGGTGTCCTAACTCAGGTTATTAACGGCGTTAAACAAGAGGGAATCTTTGATATTCTCTTCAAATTCGGAATCAATACAGAACTTTTTCCGCTTTTAATTTTTATCGGAATCGGTGCCATGATTGACTTTGGCCCTCTACTTCAAAATCCTTTTATGCTGCTCTTTGGTGCAGCAGCTCAATTTGGGATTTTCTTTGTCGTCGTCGTAGCTGTTATGGCTGGCTTTGATATCAAAGAAGCCGCTTCAATTGGTATTATCGGTGCAGCAGATGGTCCAACATCAATCTTTGTTGCTAACCAACTAGCACCAAAACTATTGGGTCCTATAACAGTTGCTGCCTATTCTTACATGGCTTTGGTACCAATTATTCAACCATTTGCTATTAAGTTGGTAACAACTAAAAAGGAACGTAAGATTCGTATGACTTATAAGGCAGAAAATGTTTCTAAAATGACGAAAATTCTGTTTCCTATTGTTATTACTATTGTAGCAGGATTTATTGCTCCAATTTCCTTGCCGCTGGTCGGTTTCTTAATGTTTGGTAATCTTTTACGTGAATGTGGTGTTTTGGATCGTCTATCGCAAACAGCACAAAATGAGTTAGTTAATATTGTTAGTATTTTGCTCGGTTTAACTATCTCTGTAAAAATGCGGGCCGACCTTTTTCTTAATGTGCAAACCTTACTTATTATCTTGTTTGGTTTAGTAGCATTCATTATGGACTCTGTTGGCGGTGTTGTTTTTGCTAAAATTATAAATCTTTTTCGTAAGGAAAAAATCAACCCAATGATTGGTGCAGCTGGGATTTCAGCTTTTCCAATGTCCAGTCGTGTTATCCAAAAGATGGCAACCGATGAAGATCCTCAAAACTTTGTTTTGATGTATGCAGTAGGTGCTAATGTTTCAGGACAGATTGCTTCTGTTATCGCAGGTGGCTTACTTCTGTCATTCTTTAGCTAA","9.80","3.95","40046","METLISGIISITIPQIIMMVIGAVLMYLGIKKEYEPTLLIPMGLGTLLVNFPGTGVLTQVINGVKQEGIFDILFKFGINTELFPLLIFIGIGAMIDFGPLLQNPFMLLFGAAAQFGIFFVVVVAVMAGFDIKEAASIGIIGAADGPTSIFVANQLAPKLLGPITVAAYSYMALVPIIQPFAIKLVTTKKERKIRMTYKAENVSKMTKILFPIVITIVAGFIAPISLPLVGFLMFGNLLRECGVLDRLSQTAQNELVNIVSILLGLTISVKMRADLFLNVQTLLIILFGLVAFIMDSVGGVVFAKIINLFRKEKINPMIGAAGISAFPMSSRVIQKMATDEDPQNFVLMYAVGANVSGQIASVIAGGLLLSFFS","971570","For other 'oad' genes see SMu0933 (oadA).For pyruvate carboxylase/oxaloacetate decarboxylase, alpha subunit see SMu0933. ","oxaloacetate decarboxylase, sodium ion pump subunit","Membrane, Cytoplasm, Extracellular","Limited matches in gapped BLAST to oxaloacetate decarboxylase, sodium ion pump subunit : residues 23-373 are 82% similar to the enzyme in S.pyogenes (gi|15675155|).Residues 24-369 are 49% similar to the protein from Archaeoglobus fulgidus (gi|11499666|).SMu0927 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005661
Family

Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit
PIRSF015658	$\"[2-373]T$	Na(+)-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit
PF03977	$\"[12-373]T$	OAD_beta
TIGR01109	$\"[14-367]T$	Na_pump_decarbB: sodium ion-translocating d

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[82-100]?$ $\"[105-125]?$ $\"[167-187]?$ $\"[208-228]?$ $\"[283-303]?$ $\"[313-333]?$ $\"[352-372]?$	transmembrane_regions

","BeTs to 4 clades of COG1883COG name: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunitFunctional Class: CThe phylogenetic pattern of COG1883 is a--k--v----------l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 259-369 are 54% similar to a (DECARBOXYLASE BETA PROTEOME SUBUNIT) protein domain (PD011639) which is seen in O28195_ARCFU.Residues 24-256 are 45% similar to a (DECARBOXYLASE BETA PROTEOME OXALOACETATE) protein domain (PD009982) which is seen in O28195_ARCFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 16:13:13 2002","Tue Jan 29 09:31:52 2002","Tue Oct 15 10:01:54 2002","Wed Jan 9 14:36:03 2002","","Wed Jan 9 14:36:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0927 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 14:36:31 2002","","No significant hits to the NCBI PDB database.","SMU.1017","","Residues 12 to 373 (E-value = 5.1e-258) place SMu0927 in the OAD_beta family which is described as Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit (PF03977)","Wed Jan 9 14:36:03 2002","24379456","","","Jockel P, Schmid M, Choinowski T, Dimroth P.Essential role of tyrosine 229 of the oxaloacetate decarboxylase beta-subunit in the energy coupling mechanism of the Na(+) pump.Biochemistry. 2000 Apr 18;39(15):4320-6.PMID: 10757980 Jockel P, Schmid M, Steuber J, Dimroth P.A molecular coupling mechanism for the oxaloacetate decarboxylase Na+ pump as inferred from mutational analysis.Biochemistry. 2000 Mar 7;39(9):2307-15.PMID: 10694397Di Berardino M, Dimroth P.Synthesis of the oxaloacetate decarboxylase Na+ pump and its individual subunits in Escherichia coli and analysis of their function.Eur J Biochem. 1995 Aug 1;231(3):790-801.PMID: 7649179 Woehlke G, Wifling K, Dimroth P.Sequence of the sodium ion pump oxaloacetate decarboxylase from Salmonella typhimurium.J Biol Chem. 1992 Nov 15;267(32):22798-803.PMID: 1331067","","Wed Jan 9 14:42:56 2002","1","","","SMU.1017","" "SMu0928","971596","971724","129","ATGAATACGAATGATCTCCTTCAAGCCTTTGAATTAATGGGCTTGGGTATGGCTGGTGTCTTTATTGTTTTAGGTATTTTATATATTGTTGCTGAACTTTTAATCAAAATTTTTCCAGTCAATAATTAA","4.00","-2.02","4592","MNTNDLLQAFELMGLGMAGVFIVLGILYIVAELLIKIFPVNN","971732","","hypothetical protein","Extracellular","No hits in gapped BLAST found.SMu0928 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-31]?$	signal-peptide
tmhmm	$\"[15-35]?$	transmembrane_regions

InterPro
IPR006495
Family

Citrate lyase acyl carrier protein CitD
PD015389	$\"[17-96]T$	CitD
PIRSF002736	$\"[1-98]T$	Citrt_lyas_gamma
PF04953	$\"[1-97]T$	CitD
TIGR01608	$\"[1-94]T$	citD

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-95 are 44% similar to a (LYASE CITRATE GAMMA ACYL) protein domain (PD015389) which is seen in Q9CGA9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 10:05:10 2002","Wed Jan 9 14:48:36 2002","Tue Oct 15 10:02:48 2002","Wed Jan 9 14:48:36 2002","","Wed Jan 9 14:48:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0929 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 14:49:10 2002","","No significant hits to the NCBI PDB database.","SMU.1019","","Residues 1 to 97 (E-value = 1.2e-58) place SMu0929 in the CitD family which is described as Citrate lyase, gamma subunit (PF04953)","Wed Jan 9 14:48:36 2002","24379458","","","Bott,M. and Dimroth,P.Klebsiella pneumoniae genes for citrate lyase and citrate lyaseligase: localization, sequencing, and expressionMol. Microbiol. 14 (2), 347-356 (1994)PubMed: 7830578Beyreuther,K., Bohmer,H. and Dimroth,P.Amino-acid sequence of citrate-lyase acyl-carrier protein fromKlebsiella aerogenesEur. J. Biochem. 87 (1), 101-110 (1978)PubMed: 352686","","Wed Jan 9 14:50:22 2002","1","","","SMU.1019","" "SMu0930","972105","973007","903","ATGGAACGCTTAAGAAGAACAATGATGTTTGTTCCCGGTGCCAATGCAGCTATGCTGCGAGATGCTCCTTTATATGGTGCGGACTCCATTATGTTTGATTTGGAAGATTCTGTTTCTCTTAAAGAAAAGGATGCTTCTAGAACATTAGTTCATTTTGCCTTAAAAACATTTGATTACAGCAAGGTGGAAACAGTTGTTCGTATCAATAGTTTAGATAGTTGCGGTGCTTTAGACATTGAAGCGGTTATTATAGCCGGTGTTGATGTTATTCGATTGCCAAAAACAGAAACTGCTAAAGATATTAGAGAAGTTGAAGATGTCATTGAAAGAGTAGAGCGTAACAATGACATCGAAATTGGGCGTACGAAAATGATGGCAGCAATTGAATCTGCCCAAGGAGTTTTGAATGCGCTTGCAATTGCTAAAGCATCAGATCGTTTAATTGGGATTGCTCTTGGAGCTGAAGATTATGTTACCAATATGAGAACGCGCCGTTATCCTGATGGTCAAGAACTTTTCTTTGCTCGCAATATGATTTTACATGCTGCTCGTGCCGCCGGTATCGCAGCAGTTGACACTGTTTATTCTGATGTTAATAATCCAGAAGGATTTCAAAATGAAGTACGTTTAATTAAGCAACTTGGATTTGATGGTAAATCTGTTATCAACCCTCGTCAAATTCCATTGGTTAACGCAATTTACGCTCCAAATGAAAAAGAAATTCAAAAGGCAAAAGAAGTTGTTTGGGCCATTCATGAGGCTGAAAGCAAAGGTTCTGGTGTTGTTTCGCTTCAGGGTAAAATGGTTGATAAACCAATTGTTGAGCGCGCTCAACGTGTTATTGCTTTAGCTAAGGCCGCTGGATTACTTACTGGGGAGGATATTTCAAATGGCAGAAAATAA","5.90","-2.30","32926","MERLRRTMMFVPGANAAMLRDAPLYGADSIMFDLEDSVSLKEKDASRTLVHFALKTFDYSKVETVVRINSLDSCGALDIEAVIIAGVDVIRLPKTETAKDIREVEDVIERVERNNDIEIGRTKMMAAIESAQGVLNALAIAKASDRLIGIALGAEDYVTNMRTRRYPDGQELFFARNMILHAARAAGIAAVDTVYSDVNNPEGFQNEVRLIKQLGFDGKSVINPRQIPLVNAIYAPNEKEIQKAKEVVWAIHEAESKGSGVVSLQGKMVDKPIVERAQRVIALAKAAGLLTGEDISNGRK","973015","For other 'cit' genes see SMu0612 (citB);SMu0613 (citZ); SMu0614 (citC); SMu0920 (citC);SMu0921 (citG); SMu0929 (citD); SMu0931 (citF) and SMu0932 (citX2). ","citrate lyase, beta subunit","Cytoplasm","Several matches in gapped BLAST to citrate lyase, beta subunit: residues 1-295 are 78% similar to the enzyme in S.pyogenes (gi|15675157|). Residues 2-290 are 55% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673172|).SMu0930 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005000
Family

HpcH/HpaI aldolase
PF03328	$\"[6-224]T$	HpcH_HpaI

InterPro
IPR006475
Family

Citrate lyase, bacterial beta subunit
TIGR01588	$\"[3-289]T$	citE

InterPro
IPR011076
Family

Malate synthase-like
SSF51645	$\"[4-288]T$	Malat_synth_like

InterPro
IPR011206
Family

Citrate lyase, beta subunit
PIRSF015582	$\"[3-291]T$	Cit_lyase_B

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.60	$\"[3-234]T$	G3DSA:3.20.20.60

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 168-286 are 58% similar to a (LYASE BETA CITRATE COMPLETE) protein domain (PD008620) which is seen in CILB_LEUMC.Residues 3-161 are 55% similar to a (LYASE BETA CITRATE COMPLETE) protein domain (PD341260) which is seen in CILB_HAEIN.Residues 5-157 are 24% similar to a (C01G10.7) protein domain (PD124872) which is seen in Q93167_CAEEL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 10:04:48 2002","Wed Jan 9 15:10:27 2002","Tue Oct 15 10:03:11 2002","Wed Jan 9 15:09:36 2002","","Wed Jan 9 15:09:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0930 is paralogously related (blast p-value < 1e-3) to SMu1089, a predicted pyruvate kinase.","Tue Jan 29 09:34:02 2002","","No significant hits to the NCBI PDB database.","SMU.1020","","No significant hits to the Pfam 11.0 database","Wed Jan 9 15:09:36 2002","24379459","","","Bekal,S., Van Beeumen,J., Samyn,B., Garmyn,D., Henini,S., Divies,C.and Prevost,H.Purification of Leuconostoc mesenteroides citrate lyase and cloning and characterization of the citCDEFG gene clusterJ. Bacteriol. 180 (3), 647-654 (1998)PubMed: 9457870","","Wed Jan 9 15:12:02 2002","1","","","SMU.1020","" "SMu0931","972994","974529","1536","ATGGCAGAAAATAAATTAGGACGTGATATTCCTCGAAAATATGCCAATCAATATGGTGTATTTGAAGGAGAACTTGCACATATTAAAAGCTATAAGGAATCCAGCCGACAAGTTAAACCGGTAAAACCTAGTGATGATAAACTTTTATCTTCTATTCATGAAGCAATTGAAAAAACAAGGCTCAAAGATGGTATGACTATTTCTTTCCATCATCATTTTCGTGAAGGGGACTATGTCATGAATATGGTGCTTGATGAAATCGCTAAGATGGGGATTAAGGATATCTCTATCGCTCCAAGTTCAATTGCCAATGTTCATGAACCACTGATTGATCATATTAAAAATGGTGTTGTTACTAATATTACTTCAAGTGGTTTGCGTGATAAAGTTGGTGCCGCCATTTCAGAAGGCATTATGGAAAATCCTGTTATTATTCGTTCTCATGGTGGACGTGCACGTGCTATTGCAACAGATGATATTCATATTGATGTTGCCTTTTTGGGAGCACCAAGTTCAGATGCCTATGGTAACGCTAACGGAACTAGAGGAAAAACAACCTGTGGTTCACTTGGTTATGCTATGATTGATGCCAAATATGCTGATCAGGTCGTCATTGTTACAGATACTTTGGTGCCATATCCTAATACACCTATTAGCATCCCGCAAACAGATGTTGATTATATTGTAGTAGTAGATGCTATTGGTGATCCAGAAGGCATTGCCAAAGGCGCTACACGTTATACTAAGAACCCTAAGGAATTACTTATTGCAGAGTATGCTGCTAAAGTGATTACAAGCTCTCCTTACTATAAGGAAGGTTTCTCTTTCCAGACAGGTACTGGAGGTGCTTCCCTTGCTGTGACACGTTTTATGCGTGAACAAATGATTAAAGATGACATCAAAGCTAATTTTGCACTCGGTGGTATTACCAATGCAATGGTTGAACTATTGGAAGAAGGTTTGGTTGATAAGATCCTCGATGTTCAAGATTTCGACCATCCATCTGCTGTATCTTTGGATCGTAATGCTGAAAAACATTATGAAATCGATGCTAATATGTATGCTTCGCCATTAAGTAAAGGTTCTGTTATCAATCAATTAGACATTTGCGTTCTCTCAGCTTTGGAGGTTGATACAAATTTTAATGTTAATGTTATGACAGGTTCGGATGGGGTTATTCGCGGAGCATCAGGTGGTCACTGCGATACAGCTTTTGCTGCTAAAATGAGTCTGGTTATCTCACCATTGGTTCGTGGACGCATTCCTACTTTTGTTGATAAGGTTAATACTGTTATTACACCAGGTACAAGTGTTGATGTTGTCGTAACAGAAGTCGGTATCGCTATCAATCCTAATCGTCCAGATTTGATTGAATATTTCAAAGATTTGAAAGTACCTCAATTGACCATTGAAGAGTTAAAAGAAAAAGCTTACGCTATTGTTGGTAATCCTCAACCTATTCAATATGGTGATAAGATTGTAGCGCTTATTGAATACCGTGATGGCAGCTTAATTGATGTTGTTCGCAATGTCTGA","5.30","-12.21","55445","MAENKLGRDIPRKYANQYGVFEGELAHIKSYKESSRQVKPVKPSDDKLLSSIHEAIEKTRLKDGMTISFHHHFREGDYVMNMVLDEIAKMGIKDISIAPSSIANVHEPLIDHIKNGVVTNITSSGLRDKVGAAISEGIMENPVIIRSHGGRARAIATDDIHIDVAFLGAPSSDAYGNANGTRGKTTCGSLGYAMIDAKYADQVVIVTDTLVPYPNTPISIPQTDVDYIVVVDAIGDPEGIAKGATRYTKNPKELLIAEYAAKVITSSPYYKEGFSFQTGTGGASLAVTRFMREQMIKDDIKANFALGGITNAMVELLEEGLVDKILDVQDFDHPSAVSLDRNAEKHYEIDANMYASPLSKGSVINQLDICVLSALEVDTNFNVNVMTGSDGVIRGASGGHCDTAFAAKMSLVISPLVRGRIPTFVDKVNTVITPGTSVDVVVTEVGIAINPNRPDLIEYFKDLKVPQLTIEELKEKAYAIVGNPQPIQYGDKIVALIEYRDGSLIDVVRNV","974537","For other 'cit' genes see SMu0612 (citB);SMu0613 (citZ); SMu0614 (citC); SMu0920 (citC);SMu0921 (citG); SMu0929 (citD); SMu0930 (citE) and SMu0932 (citX2). ","citrate lyase alpha chain","Cytoplasm","Several matches in gapped BLAST to citrate lyase, alpha subunit:residues 1-511 are 86% similar to the enzyme in S.pyogenes(gi|15675158|). Residues 3-511 are 57% similar to the protein fromLactococcus lactis subsp. lactis (gi|15673173|). SMu0931 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006472
Family

Citrate lyase, alpha subunit
PIRSF009451	$\"[2-511]T$	Citrt_lyas_alpha
PF04223	$\"[46-511]T$	CitF
TIGR01584	$\"[33-511]T$	citF

noIPR
unintegrated

unintegrated
G3DSA:3.40.1080.10	$\"[4-242]T$	G3DSA:3.40.1080.10
G3DSA:3.40.810.20	$\"[243-511]T$	G3DSA:3.40.810.20
SSF100950	$\"[45-233]T$ $\"[250-495]T$	SSF100950

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 48-511 are 60% similar to a (LYASE CITRATE TRANSFERASE ALPHA) protein domain (PD018369) which is seen in Q9RLT4_WEIPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 10:04:14 2002","Wed Jan 9 16:56:20 2002","Tue Oct 15 10:04:14 2002","Wed Jan 9 16:54:20 2002","","Wed Jan 9 16:54:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0931 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 16:55:55 2002","","No significant hits to the NCBI PDB database.","SMU.1021","","No significant hits to the Pfam 11.0 database","Wed Jan 9 16:54:20 2002","24379460","","","Bekal,S., Van Beeumen,J., Samyn,B., Garmyn,D., Henini,S., Divies,C.and Prevost,H.Purification of Leuconostoc mesenteroides citrate lyase and cloning and characterization of the citCDEFG gene clusterJ. Bacteriol. 180 (3), 647-654 (1998)PubMed: 9457870","","Wed Jan 9 16:55:55 2002","1","","","SMU.1021","" "SMu0932","974570","975058","489","ATGATGGCAGCTCGTGAACAACGTAGCTTTCGACAATTGTCTTTACTTCGACAATTTGAAGGTCAATCCTTGCTGTGTGCTAGCATGAACATCCCTGGCCCAATTAAATGCTCAGAAAGTTTAAATAAAACTTTTCAGTCAATTATTAATCTTGTCAAAGAAGATTTAAGGGGTCGTATTATTTTTGAAAGGGAAGTTCATCAAAAAACTGGCTGGGAATATTATTGTCTTTCTGACCTTCCTGTATCAGAATTGAAAACGAAGATGATTGCTATTGAGACAAAAATTAGCATTGGCCGTCTGATGGATTTGGATGTCTTACATCTAGTTAATGGTATACCGCAGCCAATCAGTCGTCAGGAACTCGGTTTTCCTAGACGTCAATGTTATATTTGCCAAAACGATGCTAAAGTTTGTAGCCGTTCTCGTAAACACAGTGTTATTGAAATGCAAGAAGCTATCGCAAAATTCATCAAAATCAATCACTAA","9.40","7.67","18706","MMAAREQRSFRQLSLLRQFEGQSLLCASMNIPGPIKCSESLNKTFQSIINLVKEDLRGRIIFEREVHQKTGWEYYCLSDLPVSELKTKMIAIETKISIGRLMDLDVLHLVNGIPQPISRQELGFPRRQCYICQNDAKVCSRSRKHSVIEMQEAIAKFIKINH","975066","For other 'cit' genes see SMu0612 (citB);SMu0613 (citZ); SMu0614 (citC); SMu0920 (citC);SMu0921 (citG); SMu0929 (citD); SMu0930 (citE) and SMu0931 (citF). ","conserved hypothetical protein (possible CitXG protein)","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein and to CitXG protein : residues 1-158 are 50% similar to the protein in S.pyogenes (gi|15675159|) and residues 1-162 are 30% similar to CitXG protein from Haemophilus influenzae (gi|14286109|). SMu0932 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005551
Family

Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
PF03802	$\"[1-161]T$	CitX

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-158 are 33% similar to a (CITX PROTEOME COMPLETE) protein domain (PD022557) which is seen in CITG_LEUMC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 10:07:06 2002","Tue Oct 15 10:07:06 2002","Tue Oct 15 10:07:06 2002","Wed Jan 9 16:59:32 2002","","Wed Jan 9 16:59:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0932 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 21 09:57:03 2002","","No significant hits to the NCBI PDB database.","SMU.1022","","Residues 1 to 161 (E-value = 2.7e-43) place SMu0932 in the CitX family which is described as Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (PF03802)","Wed Jan 9 16:59:32 2002","24379461","","","","","","1","","","SMU.1022","" "SMu0933","975071","976462","1392","ATGACAAAAATCCATATTATGGAGACGGTTTTAAGAGACGGGCAGCAAAGTCAAATTGCAACACGAATGACAACTAAAGAAATGTTACCTGTTCTTAAAACTTTGGATGAAGCTGGATATCGTGCTTTAGAGATGTGGGGTGGAGCGACCTTTGATTCCTGCCTTCGTTTTTTAAACGAGGATCCATGGGAAAGATTGCGTACTATTCGTAAACATGTTAAAAAGACAAAATTGCAGATGTTACTGCGTGGTCAAAATTTATTGGGCTATCGCAATTATGCTGATGATGTTGTTTGCTCTTTCATTCAAAAATCAGTTGAAAATGGTATTGATATCGTCCGTATTTTTGATGCTTTGAATGATCCGCGTAATCTACAAACGGCAGTTAGTGCTACTAAGGAAGCTGGCGGACATGCTCAAGTGGCTATTTCTTATACAACTAGTCCCGTTCATACAGTTGATTATTTTGTTCATTTATCTAAAGAATATGCTGAAATCGGAGCAGACTCCATTTGTATCAAGGATATGGCTGGTGTTTTAACACCTCAAACAGGTTATGACCTTGTAAAGCGTATCAAAGAAGCGGTTGATTTGCCACTAGAAGTACATACTCATGCGACAAGTGGTATCTCTGAAATGACTTATCTTAAAGTTGCAGAAGCTGGTGCTGATATTATTGATACTGCTGTATCTTCCTTTGCAGGCGGAACTAGTCAACCAGCGACAGAATCTATAGTTATCGCTTTAGAAGAACTTGGTTTTGAAACAGGTGTTGATCTACAGAAAGTTGAGACAGCAGCAGCTCACTTCAATACTATCCGTGATCATTATCGTGCAGAAGGTCTTTTAAATCCTAAGGTTAAGGATGTTGAGCCTAAAACTTTGATTTATCAAGTTCCAGGCGGTATGTTGTCTAATTTGCTTAGTCAATTAACAGAACAGGGATTGGCCAATCGCTATGAAGAAGTGTTGGCCGAAGTTCCTCGTGTTAGAGCCGATTTGGGTTATCCGCCATTGGTTACACCTTTATCGCAAATGGTTGGGACACAATCTCTACTGAACATTATCTCTGGTGAACGCTATAAAGTTGTTCCTAACGAAATTAAGGATTATGTTCGTGGACTTTATGGACGTCCACCTGCAGCCATTGCCGATGATATTAAAGAAAAAATCATTGGGGATGAAGAAGTGATTACTGTTCGTCCAGCAGATTTAATCGAGCCTCAATTACCTAAACTTAGACAGGAAATTGCTGAATATGCAAGAAGTGAAGAAGATGTTTTAAGTTACGCTTCTTTCCCGCAACAAGCAAAAGATTTCTTGGGGCGTCGTGAAGATCCTTTCTACGATGTACCTGTACAAAATGTTTCTGTTACCATTGATTTTGATTAA","4.90","-15.92","51476","MTKIHIMETVLRDGQQSQIATRMTTKEMLPVLKTLDEAGYRALEMWGGATFDSCLRFLNEDPWERLRTIRKHVKKTKLQMLLRGQNLLGYRNYADDVVCSFIQKSVENGIDIVRIFDALNDPRNLQTAVSATKEAGGHAQVAISYTTSPVHTVDYFVHLSKEYAEIGADSICIKDMAGVLTPQTGYDLVKRIKEAVDLPLEVHTHATSGISEMTYLKVAEAGADIIDTAVSSFAGGTSQPATESIVIALEELGFETGVDLQKVETAAAHFNTIRDHYRAEGLLNPKVKDVEPKTLIYQVPGGMLSNLLSQLTEQGLANRYEEVLAEVPRVRADLGYPPLVTPLSQMVGTQSLLNIISGERYKVVPNEIKDYVRGLYGRPPAAIADDIKEKIIGDEEVITVRPADLIEPQLPKLRQEIAEYARSEEDVLSYASFPQQAKDFLGRREDPFYDVPVQNVSVTIDFD","976470","For other 'oad' genes see SMu0927 (oadB).For oxaloacetate decarboxylase, sodium ion pump subunit see SMu0927.","pyruvate carboxylase/oxaloacetate decarboxylase, alpha subunit","Cytoplasm","Several matches in gapped BLAST to oxaloacetate decarboxylase alpha chain:residues 1-461 are 82% similar to the protein in S.pyogenes (gi|15675160|). Residues 4-441 are 55% similar to the protein from Methanococcus jannaschii (gi|15669416|). SMu0933 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000891
Domain

Pyruvate carboxyltransferase
PF00682	$\"[12-276]T$	HMGL-like
PS50991	$\"[4-264]T$	PYR_CT

InterPro
IPR003379
Domain

Conserved carboxylase region
PF02436	$\"[294-461]T$	PYC_OADA

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[2-267]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR18866	$\"[1-445]T$	PTHR18866
PTHR18866:SF1	$\"[1-445]T$	PTHR18866:SF1
SSF51569	$\"[1-303]T$	SSF51569
SSF89000	$\"[299-458]T$	SSF89000

","BeTs to 10 clades of COG1038COG name: Pyruvate carboxylase, C-terminal domain/oxaloacetate decarboxylase, alpha subunitFunctional Class: EThe phylogenetic pattern of COG1038 is amtkYQv--br------l---Number of proteins in this genome belonging to this COG is 2","***** IPB003379 (Conserved carboxylase domain) with a combined E-value of 1.2e-148. IPB003379A 6-28 IPB003379B 41-69 IPB003379C 70-96 IPB003379D 97-132 IPB003379E 152-195 IPB003379F 196-241 IPB003379G 287-331","Residues 4-117 are 65% similar to a (PYRUVATE CARBOXYLASE BIOTIN LIGASE) protein domain (PD002904) which is seen in Q9HH18_METBA.Residues 173-263 are 34% similar to a (ALDOLASE 4-HYDROXY-2-OXOVALERATE) protein domain (PD350071) which is seen in Q9X9Q0_STRTE.Residues 159-264 are 46% similar to a (CARBOXYLASE PYRUVATE BIOTIN LIGASE) protein domain (PD414942) which is seen in Q9CHQ7_LACLA.Residues 156-260 are 57% similar to a (PYRUVATE CARBOXYLASE BIOTIN PROTEOME) protein domain (PD414925) which is seen in O83095_TREPA.Residues 118-154 are 64% similar to a (SUBUNIT PROTEOME COMPLETE ALPHA) protein domain (PD378263) which is seen in Q9WXY2_THEMA.Residues 270-441 are 51% similar to a (PYRUVATE CARBOXYLASE BIOTIN LIGASE PROTEOME COMPLETE) protein domain (PD328972) which is seen in Q9HH18_METBA.Residues 162-249 are 53% similar to a (LYASE SYNTHASE HOMOCITRATE FIXATION) protein domain (PD344479) which is seen in O58564_PYRHO.Residues 118-276 are 57% similar to a (LYASE SYNTHASE 2-ISOPROPYLMALATE COMPLETE) protein domain (PD327958) which is seen in PYCB_METJA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 16:26:40 2002","Thu Jan 10 08:05:29 2002","Tue Oct 15 10:09:44 2002","Wed Jan 9 17:03:06 2002","Wed Jan 9 17:03:06 2002","Wed Jan 9 17:03:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0933 is paralogously related (blast p-value < 1e-3) to SMu1262, a predicted 2-isopropylmalate synthase.","Tue Jan 29 09:40:08 2002","","No significant hits to the NCBI PDB database.","SMU.1023","","Residues 12 to 276 (E-value = 3.4e-45) place SMu0933 in the HMGL-like family which is described as HMGL-like (PF00682)Residues 294 to 463 (E-value = 1.4e-57) place SMu0933 in the PYC_OADA family which is described as Conserved carboxylase domain (PF02436)","Wed Jan 9 17:03:06 2002","24379462","","","Schwarz,E., Oesterhelt,D., Reinke,H., Beyreuther,K. and Dimroth,P.The sodium ion translocating oxalacetate decarboxylase ofKlebsiella pneumoniae. Sequence of the biotin-containingalpha-subunit and relationship to other biotin-containing enzymesJ. Biol. Chem. 263 (20), 9640-9645 (1988)PubMed: 2454915","","Wed Jan 9 17:05:42 2002","1","","","SMU.1023","" "SMu0934","976691","976530","162","GTGTTTTTTGATGAAATTAACGTATATGAAAAGACTTTCAAATCACTTGACAAACTTGAAAAAGCCATCACTAATTACATTTTTTATTACAACAATAAACGAATCAAGACAAAACTAAAAGGACTCAGCCCTGTGCAATACAGGACTAAATCCTTTCAATAA","10.60","5.98","6442","MFFDEINVYEKTFKSLDKLEKAITNYIFYYNNKRIKTKLKGLSPVQYRTKSFQ","976544","","transposase fragment, IS861","Cytoplasm, Extracellular","Matches in gapped BLAST to a previously published sequence from S.mutans:residues 9-52 are 79% similar to transposase (gi|3873218|).Residues 10-53 are 86% similar to the enzyme in S.pyogenes(gi|15675275|). Residues 9-52 are 84% similar to the protein fromS.pneumoniae (gi|15673172|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (2e-17).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[9-49]T$	rve

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 9-48 are 82% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in Q9KK23_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 10 08:09:08 2002","Thu Jan 10 08:09:08 2002","Tue Oct 15 10:10:43 2002","Thu Jan 10 08:08:40 2002","","Thu Jan 10 08:08:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0934 is paralogously related (blast p-value < 1e-3) to SMu0537, SMu1719, SMu1283, SMu1258, SMu0695, SMu0514, SMu0395, and SMu1715, all predicted transposases.","Tue Jan 29 09:44:46 2002","","No significant hits to the NCBI PDB database.","SMU.1024c","","No significant hits to the Pfam 11.0 database","Thu Jan 10 08:08:40 2002","24379463","","","Rubens,C.E., Heggen,L.M. and Kuypers,J.M.IS861, a group B streptococcal insertion sequence related to IS150and IS3 of Escherichia coliJ. Bacteriol. 171 (10), 5531-5535 (1989)PubMed: 2477359","","Thu Jan 10 08:11:28 2002","1","","16","SMU.1024c","" "SMu0935","976838","977263","426","ATGGAAATTCAAAATTCGTTAGGATTTATTCTGAACACAAGTGCTAAATTGATGAAGAGGCGTTTAGATACGGAACTGAAAGCAGGATTTGATATTACTTCCTCGCAATGGGCAGTCTTGAAACTATTATCTTGTGAAGAGGATTTATCACAAGCAGAGATTTCAGATAAGCTGAATGCGGACAGAGCAACATGCGGAGCAGTGATTGAAAAACTCATGTCAAAGGGTTTTGTGACAAAAACGCTGTCAAAAGATGACCGCAGAAGCTATAAGGTAAAGATTTCTCCCAAGGCTTTAGCCATTTTAGAGAAAATGGCACAAAAGGCTGATGAAGTTAATGATTTAGCAATACAAGGATTAACCAGTGATGAACTAAAAATATTCATCAAATGCTTGCATACAATCACAGGAAATTTTGTAAAATAG","8.80","3.09","15666","MEIQNSLGFILNTSAKLMKRRLDTELKAGFDITSSQWAVLKLLSCEEDLSQAEISDKLNADRATCGAVIEKLMSKGFVTKTLSKDDRRSYKVKISPKALAILEKMAQKADEVNDLAIQGLTSDELKIFIKCLHTITGNFVK","977271","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator:residues 1-141 are 49% similar to the protein in S.criceti(gi|15383630|). Residues 1-138 are 30% similar to the protein fromClostridium acetobutylicum (gi|15896901|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1910 (5e-05).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PR00598	$\"[49-65]T$ $\"[66-81]T$ $\"[85-101]T$ $\"[115-135]T$	HTHMARR
PF01047	$\"[32-101]T$	MarR
SM00347	$\"[25-125]T$	HTH_MARR
PS50995	$\"[4-137]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[32-105]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[3-139]T$	SSF46785

","BeTs to 5 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class: KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","No significant hits to the Blocks database.","Residues 50-141 are 25% similar to a (TRANSCRIPTION DNA-BINDING REGULATION) protein domain (PD001097) which is seen in Q9ZFQ9_BURCE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 10 08:18:35 2002","Tue Jan 15 13:11:45 2002","Tue Oct 15 10:11:15 2002","Thu Jan 10 08:15:55 2002","","Thu Jan 10 08:15:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0935 is paralogously related (blast p-value < 1e-3) to SMu1787 and SMu0347,both predicted transcriptional regulators,and SMu0111,a predicted transcriptional regulator (MarR family).","Tue Jan 15 13:18:46 2002","","No significant hits to the NCBI PDB database.","SMU.1025","","Residues 32 to 135 (E-value = 1.5e-23) place SMu0935 in the MarR family which is described as MarR family (PF01047)","Thu Jan 10 08:15:55 2002","24379464","","","Libby,S.J., Goebel,W., Ludwig,A., Buchmeier,N., Bowe,F., Fang,F.C.,Guiney,D.G., Songer,J.G. and Heffron,F.A cytolysin encoded by Salmonella is required for survival withinmacrophagesProc. Natl. Acad. Sci. U.S.A. 91 (2), 489-493 (1994)PubMed: 8290552Ludwig,A., Tengel,C., Bauer,S., Bubert,A., Benz,R., Mollenkopf,H.J. and Goebel,W.SlyA, a regulatory protein from Salmonella typhimurium, induces ahaemolytic and pore-forming protein in Escherichia coliMol. Gen. Genet. 249 (5), 474-486 (1995)PubMed: 8544813Dehoux,P. and Cossart,P.Homologies between salmolysin and some bacterial regulatoryproteinsMol. Microbiol. 15 (3), 591 (1995)PubMed: 7783629","","Thu Jan 10 08:27:35 2002","1","","16","SMU.1025","" "SMu0936","977310","977690","381","ATGAAAATTACAATGTGGGTTATGCTAATCGTTGGAATAATTGAACTAACAGCAAATACATTTTTTTTAATCAGTTTAAGCAGAGGAAAAGACTTGAAAATTGCCAAAAAATTTCATGGTGATTTTCCTATGTATGCGACTGACAAGGCATGGCTTGTCAAAATAGTATCATCAGTAATCCTCGGAATAGTTGCTCTTCTTGCCAGCTACGCAATAAACAAAGATTTTTCCATAAAGATAATATTGTCCAATATGTTTTCCTTTGGAATGCTGATTATGTGTATAACTCAAGCCTTATTATATGGTAAAAAACATATACCTGCCCGAATAAGCATAGTTTTAGGAATTGTATTCGTTATGCTGACTATTTTAAAATTATAA","10.80","9.41","14081","MKITMWVMLIVGIIELTANTFFLISLSRGKDLKIAKKFHGDFPMYATDKAWLVKIVSSVILGIVALLASYAINKDFSIKIILSNMFSFGMLIMCITQALLYGKKHIPARISIVLGIVFVMLTILKL","977698","","conserved hypothetical protein","Membrane, Cytoplasm","Only a single significant hit in gapped BLAST to hypothetical protein: residues 1-121 are 38% similar to the protein in S.criceti (gi|15383631|).SMu0936 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[50-70]?$ $\"[80-102]?$ $\"[106-124]?$	transmembrane_regions

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[17-30]T$ $\"[38-61]T$	HTHTETR
PF00440	$\"[17-63]T$	TetR_N
PS50977	$\"[11-71]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[11-78]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[4-63]T$	Homeodomain-rel

","BeTs to 8 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 2.9e-07. IPB001647 29-59","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 10 08:34:41 2002","Thu Jan 10 08:31:57 2002","Tue Oct 15 10:11:45 2002","Thu Jan 10 08:31:57 2002","Thu Jan 10 08:31:57 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0937 is paralogously related (blast p-value < 1e-3) to SMu0214, a predicted transcriptional regulator.","Tue Jan 29 09:46:33 2002","","No significant hits to the NCBI PDB database.","SMU.1027","","Residues 17 to 63 (E-value = 1.6e-08) place SMu0937 in the TetR_N family which is described as Bacterial regulatory proteins, tetR family (PF00440)","Thu Jan 10 08:31:57 2002","24379466","","","","","","1","","16","SMU.1027","" "SMu0938","978482","979516","1035","GTGAATTATAAAAATCCATATGAACAATTGTCTGGAAAACTAAATAATCGGAAGCTGATAAATGCTGGTTTTTCAGAAAAAACTTATGATACAAGGAGTGTTAAACTGAACTATGTGGTTGGTCCTAACAATGGACCAAGTTTATTGTTGATTCCTGCTCAAATGGGCATATGGGAAAGTTATAAAAAAGTACTTTTACCATTGTCGAAACATTTTCAAGTATATGCCATAGATGTGAGAGGGCATGGAAAATCTTCTTGGACACCGGGACACTATTCATGGAAAATTGTTGGTGAGGATATAAAAACATTTATAGAAAATGTAATAAAACAGAAAGTGATAATTAGTGGAAACTCATCAGGCGGTATTGTTGCTCTATGGTGTTCTGCTAATATTCCTGAATATGTTTCCGGAATCATTATTGAGGACGCACCTATTTTTTCTGCTGAAATGCCACGTTTTAAAGAACGAGATAAATTTGTTTATAACGGACTAAAACACCTTGTTAATCAAATTGGAAATATACCAGATAGAGATTTAGCAAATTATTTTAAAGATATGGAAGTACCAGCCACTGATAAAAGAATTAAAAGAATTCCAGATTGGTTTGTCAGTTGGTTATCACAGAAGATAAAGAAGTTTCAAAATAAACACCCTGATAGTCCAGTTGAAATTGGATTTCCAAATAGCCTACGTTTACTCATTAAATCATTATCTATGTTTGACCCAGATTTTGCCAGAGCATTTGTAGATGGTAGATTTTATGATGGTATTGACCATGCAGAAGCTTTTAAGAAAGCAAAATGTCCTATATTACTTATTCAAGCCAATTGGAAACGATATGAAAATTACGGACTTGTAGGAGCATTTGATGATGATGACGCTCAGCACGCTATTTCCTTAGCTCCGCAAATAATATATAAAAAAGTTTCTGCTAATCATGTTATTCATGCTTTCAAGCCAAAAGAGTACATTAAACTATTGTTAGAATTCAAAAAAATAGTACCTGATAGTTCGATTTGTGATGGGAAGTGA","10.00","13.03","39167","MNYKNPYEQLSGKLNNRKLINAGFSEKTYDTRSVKLNYVVGPNNGPSLLLIPAQMGIWESYKKVLLPLSKHFQVYAIDVRGHGKSSWTPGHYSWKIVGEDIKTFIENVIKQKVIISGNSSGGIVALWCSANIPEYVSGIIIEDAPIFSAEMPRFKERDKFVYNGLKHLVNQIGNIPDRDLANYFKDMEVPATDKRIKRIPDWFVSWLSQKIKKFQNKHPDSPVEIGFPNSLRLLIKSLSMFDPDFARAFVDGRFYDGIDHAEAFKKAKCPILLIQANWKRYENYGLVGAFDDDDAQHAISLAPQIIYKKVSANHVIHAFKPKEYIKLLLEFKKIVPDSSICDGK","979524","","hydrolase or acyltransferase","Cytoplasm, Periplasm, Extracellular","Weak matches in gapped BLAST to hydrolase and acyltransferase. Residues 24-328 are 29% similar to gi|11061568| from S.coelicolor. Residues 19-186 are 27% similar to gi|16766380| from Salmonellatyphimurium The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2132 (3e-07).","

InterPro
IPR000073
Domain

Alpha/beta hydrolase fold-1
PF00561	$\"[72-330]T$	Abhydrolase_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[24-331]T$	no description
PTHR10992	$\"[46-151]T$	ALPHA/BETA HYDROLASE RELATED
PTHR10992:SF14	$\"[46-151]T$	HYDROLASE

","BeTs to 5 clades of COG0596COG name: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)Functional Class: RThe phylogenetic pattern of COG0596 is A---Yq-CEBR-ujgp----XNumber of proteins in this genome belonging to this COG is 2","***** PR00111 (Alpha/beta hydrolase fold signature) with a combined E-value of 2.2e-06. PR00111A 71-86 PR00111B 115-128","Residues 87-328 are 25% similar to a (HYDROLASE) protein domain (PD313836) which is seen in Q9EWL3_STRCO.Residues 41-86 are 50% similar to a (HYDROLASE COMPLETE PROTEOME EPOXIDE CATABOLISM) protein domain (PD363858) which is seen in Q9EWL3_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 10 08:56:39 2002","Tue Jan 29 09:47:05 2002","Tue Oct 15 10:12:04 2002","Thu Jan 10 08:56:12 2002","Thu Jan 10 08:56:12 2002","Thu Jan 10 08:56:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0938 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 10 08:56:39 2002","","No significant hits to the NCBI PDB database.","SMU.1028","","Residues 72 to 330 (E-value = 4.2e-09) place SMu0938 in the Abhydrolase_1 family which is described as alpha/beta hydrolase fold (PF00561)","Thu Jan 10 08:56:12 2002","24379467","","","","","","1","","16","SMU.1028","" "SMu0939","980040","980396","357","ATGAAACCGTCATCTTTTCAGGAAACGATAGAAAATCAGTTTGACTACATCTGCAAACAGGCTATGGAAGATGAGCGAAAGGACTATTTCAAACAGCTTTCCAGACTGGCAAAGCATGAGGTGTCCTTTTCGGAAATTGGCGATTATCTTGTCAGCCAGTTTGCCACAACAGACAGTTATTCAACGGATTTTCAGATTTTTATGTTGAATGGCATATCCATCGGGATTGAGAATGACCTGCTAAGCGAAGCACTGCGGAACTTGCCGAGCAACAAGCGTGAGATTCTGCTTCTGTTCTATTTTATGGATATGAGCGATTCAGAAATCGCAGACATGCTGAAATCGCAGACATGCTGA","4.30","-8.86","13724","MKPSSFQETIENQFDYICKQAMEDERKDYFKQLSRLAKHEVSFSEIGDYLVSQFATTDSYSTDFQIFMLNGISIGIENDLLSEALRNLPSNKREILLLFYFMDMSDSEIADMLKSQTC","980404","Note tandem repeats at 980372,980409.","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and ORF7. Residues 1-58 are 62% similar to gi|2467235| from Lactococcus lactis. Residues 1-113 are 69% similar to ORF7gi|13274512| from Clostridium perfringens. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0919 (2e-52).","

InterPro
IPR013249
Domain

RNA polymerase sigma factor 70, region 4 type 2
PF08281	$\"[78-113]T$	Sigma70_r4_2

InterPro
IPR013324
Domain

RNA polymerase sigma factor, regions 3 and 4
SSF88659	$\"[70-113]T$	Sigma_r3_r4

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 59-114 are 83% similar to a (COMPLETE XIS-TN INT-TN START) protein domain (PD028552) which is seen in Q47739_ENTFA.Residues 1-58 are 82% similar to a (COMPLETE XIS-TN INT-TN START) protein domain (PD019539) which is seen in Q47739_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 30 11:24:55 2002","Thu Jan 10 09:52:31 2002","Wed Oct 30 11:24:55 2002","Thu Jan 10 09:52:31 2002","","Thu Jan 10 09:52:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0939 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 10 09:55:02 2002","","No significant hits to the NCBI PDB database.","SMU.1029","","No significant hits to the Pfam 11.0 database","Thu Jan 10 09:52:31 2002","24379468","","","","","","1","","16","SMU.1029","" "SMu0940","980476","980706","231","ATGAAAAAGCATTACCCTCTTGTTCCCTTTCCTCTCATTGTAAAGGCTACTGACAGCAATGCGGAAGCAATCAATCAGATTATCCGGCACTATCGGGGATATATGACAAAACGTTCCCTGCGTCTGATGAAAGACGAGTACGGAAATCAAAGCATGGTTGTAGATGAAGTTTTGCGTGGACGAATGGAAACAAGACTGATTACAAAGATTCTGTCATTTGAAATCAAGTGA","10.70","6.46","8967","MKKHYPLVPFPLIVKATDSNAEAINQIIRHYRGYMTKRSLRLMKDEYGNQSMVVDEVLRGRMETRLITKILSFEIK","980714","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical proteins and ORF8. Residues 1-76 are 86% similar to gi|431129| from Enterococcus faecalis. Residues 1-76 are 76% similar to hypothetical protein gi|15923384| from Staphylococcus aureus. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0918 (6e-35).","

InterPro
IPR000048
Domain

IQ calmodulin-binding region
PS50096	$\"[20-49]T$	IQ

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 7-72 are 87% similar to a (XIS-TN COMPLETE INT-TN DS16) protein domain (PD057749) which is seen in Q57216_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 29 09:47:44 2002","Thu Jan 10 16:25:39 2002","Thu Jan 10 16:25:39 2002","Thu Jan 10 16:25:39 2002","","Thu Jan 10 16:25:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0940 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 09:47:44 2002","","No significant hits to the NCBI PDB database.","SMU.1030","","No significant hits to the Pfam 11.0 database","Thu Jan 10 16:25:39 2002","24379469","","","","","","1","","16","SMU.1030","" "SMu0941","981073","981276","204","ATGAATCAAGTTGATGTTCCTATCTGGGAACGCTACACGCTGACGATTGAAGAAGCTGCTAAGTATTTCCGTATCGGTGAAAATAAGTTACGCCGTTTAGCAGAGGAAAATAAAAACGCAGGCTGGCTGATTATGAATGGAAACAGGATTCAGATTAAGCGAAAACAATTTGAAAAAGTCATAGATACATTAGATGTCATATAG","10.00","1.99","8004","MNQVDVPIWERYTLTIEEAAKYFRIGENKLRRLAEENKNAGWLIMNGNRIQIKRKQFEKVIDTLDVI","981284","","excisionase","Cytoplasm","Limited matches in gapped BLAST to excisionase: residues 1-67 are 89% similar to the enzyme in S.pneumoniae (gi|139811|). Residues 5-67 are 84% similar to the protein from Enterococcus faecalis (gi|8100683|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0916 (3e-32).","

InterPro
IPR015122
Family

Excisionase from transposon Tn916
PF09035	$\"[1-67]T$	Tn916-Xis

noIPR
unintegrated

unintegrated
PD054970	$\"[5-53]T$	PD054970

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-53 are 93% similar to a (EXCISIONASE DNA ELEMENT EXCISASE) protein domain (PD054970) which is seen in XIS_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 10 10:24:07 2002","Thu Jan 10 10:24:07 2002","Tue Oct 15 10:39:31 2002","Thu Jan 10 10:23:33 2002","","Thu Jan 10 10:23:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0941 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 10 10:24:07 2002","","No significant hits to the NCBI PDB database.","SMU.1031","","No significant hits to the Pfam 11.0 database","Thu Jan 10 10:23:33 2002","24379470","","","Poyart-Salmeron,C., Trieu-Cuot,P., Carlier,C. and Courvalin,P.Molecular characterization of two proteins involved in the excision of the conjugative transposon Tn1545: homologies with other site-specific recombinasesEMBO J. 8 (8), 2425-2433 (1989)PubMed: 2551683","","Tue Oct 15 10:39:31 2002","1","","16","SMU.1031","" "SMu0942","981357","982523","1167","ATGTCAGAAAAAAGACGTGACCATAAAGATCGGATTTTGAGGACTGGAGAGAGCCAGAGAAAAGACGGAAGATACTTATATAAATATGTAGATTCATTTGGAGAAACACAATTTATCTATTCATGGAAACTTGTGGCTACGGACAGAGTTCCGGCAGGTAAACGGGATTGTATTGCACTGCGTGAAAAAATCGCAGAAATACAAAAAGATGTTCAAGATGGGATTGATGTTATCGGCAAGAAGATGACGCTTTGCCAGCTTTACGCTAAACAAAATGCCGTGCGTCCCAATGTAAAAGCAAACACAAAGAGCGGACGTAAATATCTGATGGAGATTTTGAAAAACGATAGGCTGGGAGCAAGAAGCATAGACAGCATTAAACCATCTGACGCTAAAGAATGGGCTATCAGAATGAGCGAAAACGGCTTTGCCTACTCAACCATCAATAACTATAAGCGGTCACTGCGAGCTTCATTTTACATTGCGATACAAGATGATTATGTGAGAAAGAATCCGTTTGATTTTCAGCTTAATACTGTTATTGATGATGATACTATTCCTAAAACAGTATTAACATCAGAACAGGAAGCAAGACTGCTTGATTTCGCAAAGTCCGATACGGTCTATCACAAGAATTATGATGAAATTCTGATATTGTTAAAAACCGGACTTCGCATTTCAGAGCTATGCGGTCTGACTGTTTCGGATTTGGATTTTGAAAATCATCTTATCTCGGTTGACCATCAGCTATTAAGAAACACGGAGCTTGGGTATTACATTGAAACGCCCAAAACCAAAAGCAGTGAGCGACAAATACCAATGGAAGCTACCTGTCAGGCATTAAAAAGGACACTGGCAAAGCGAGATGACAGAAAGTGTGTTGAGATTGACGGTTACAGCCATTTTCTTTTCCTCAATAGAAAGGGATATCCGAAAACCTCAGGTGACTTTGACAGAATATTGAGAAACCTCATTAAAAAGTACAACAAATACCATGAGGAAAAGTTGCCACATATCACACCGCACACACTTAGACATACATTCTGTACCAACTGTGCCAATGCCGGTATGAATCCAAAAGCCCTGCAATATATTATGGGACATGCAAACATAACTATGACACTAAACTATTATGCACATGCGACCTATAAATTCGGCTATGGATGA","10.00","17.33","45012","MSEKRRDHKDRILRTGESQRKDGRYLYKYVDSFGETQFIYSWKLVATDRVPAGKRDCIALREKIAEIQKDVQDGIDVIGKKMTLCQLYAKQNAVRPNVKANTKSGRKYLMEILKNDRLGARSIDSIKPSDAKEWAIRMSENGFAYSTINNYKRSLRASFYIAIQDDYVRKNPFDFQLNTVIDDDTIPKTVLTSEQEARLLDFAKSDTVYHKNYDEILILLKTGLRISELCGLTVSDLDFENHLISVDHQLLRNTELGYYIETPKTKSSERQIPMEATCQALKRTLAKRDDRKCVEIDGYSHFLFLNRKGYPKTSGDFDRILRNLIKKYNKYHEEKLPHITPHTLRHTFCTNCANAGMNPKALQYIMGHANITMTLNYYAHATYKFGYG","982531","","transposon/phage-related integrase","Cytoplasm","Matches in gapped BLAST to transposon integrase; Tn916 ORF3-like. Residues 1-383 are 79% similar to gi135951 from S.pneumoniae and to gi135952 from Enterococcus faecalis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0915 (0.0).","

InterPro
IPR002104
Domain

Integrase, catalytic core, phage
PF00589	$\"[199-388]T$	Phage_integrase

InterPro
IPR004191
Domain

Integrase, Tn916-type, N-terminal DNA binding
PF02920	$\"[3-69]T$	Integrase_DNA

InterPro
IPR010998
Domain

Integrase, Lamba-type, N-terminal
SSF47823	$\"[80-173]T$	L_intgrse_like_N

InterPro
IPR011010
Domain

DNA breaking-rejoining enzyme, catalytic core
SSF56349	$\"[189-383]T$	DNA_brk_join_enz

InterPro
IPR013762
Domain

Integrase-like, catalytic core, phage
G3DSA:1.10.443.10	$\"[190-384]T$	Phage_intgr_like

noIPR
unintegrated

unintegrated
G3DSA:3.30.160.60	$\"[3-71]T$	G3DSA:3.30.160.60
SSF54171	$\"[3-73]T$	SSF54171

","BeTs to 12 clades of COG0582COG name: IntegraseFunctional Class: LThe phylogenetic pattern of COG0582 is aMtK-qvcEBRHUJ---LINXNumber of proteins in this genome belonging to this COG is 4","***** IPB002104 (Phage integrase family) with a combined E-value of 2.2e-10. IPB002104A 342-356 IPB002104B 366-377","Residues 45-81 are 86% similar to a (TRANSPOSON TN916 FROM DNA) protein domain (PD012630) which is seen in Q56399_ENTFA.Residues 335-383 are 91% similar to a (INTEGRASE COMPLETE DNA PROTEOME) protein domain (PD000437) which is seen in Q47740_ENTFA.Residues 82-185 are 83% similar to a (TRANSPOSON TN916 FROM DS16) protein domain (PD010617) which is seen in Q56400_ENTFA.Residues 186-246 are 72% similar to a (COMPLETE PROTEOME INTEGRASE/RECOMBINASE) protein domain (PD000548) which is seen in Q47740_ENTFA.Residues 342-383 are 85% similar to a (DNA INTEGRASE PLASMID RECOMBINATION) protein domain (PD015483) which is seen in O85368_ENTFA.Residues 235-377 are 28% similar to a (INTEGRASE) protein domain (PD072755) which is seen in Q54877_STRPN.Residues 247-334 are 66% similar to a (TRANSPOSON TN916 FROM DS16) protein domain (PD395730) which is seen in Q47740_ENTFA.Residues 223-326 are 32% similar to a (INTEGRASE PROTEOME COMPLETE DNA) protein domain (PD009586) which is seen in O54477_STAAU.Residues 1-44 are 86% similar to a (DNA FROM TRANSPOSON INTEGRASE) protein domain (PD020410) which is seen in TNR5_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 08:17:33 2002","Tue Sep 26 12:29:17 2006","Tue Sep 26 12:29:17 2006","Fri Jan 11 08:16:48 2002","Wed Jan 2 16:15:41 2002","Wed Jan 2 16:15:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0942 is paralogously related (blast p-value < 1e-3) to SMu0172, SMu0200, and SMu0943, all suspected integrases.","Tue Jan 29 09:50:06 2002","Tue Sep 26 12:29:17 2006","pdb1BB8 N-Terminal Dna Binding Domain From Tn916 Integrase... 132 9e-032pdb1B69A Chain A, The Solution Structure Of Tn916 Integrase N... 126 5e-030","SMU.1032","","Residues 3 to 69 (E-value = 2.5e-41) place SMu0942 in the Integrase_DNA family which is described as DNA binding domain of tn916 integrase (PF02920)Residues 191 to 388 (E-value = 3e-48) place SMu0942 in the Phage_integrase family which is described as Phage integrase family (PF00589)","Tue Sep 26 12:29:17 2006","24379471","","","Poyart-Salmeron,C., Trieu-Cuot,P., Carlier,C. and Courvalin,P.Molecular characterization of two proteins involved in the excision of the conjugative transposon Tn1545: homologies with other site-specific recombinasesEMBO J. 8 (8), 2425-2433 (1989)PubMed: 2551683Flannagan,S.E., Zitzow,L.A., Su,Y.A. and Clewell,D.B.Nucleotide sequence of the 18-kb conjugative transposon Tn916 fromEnterococcus faecalisPlasmid 32 (3), 350-354 (1994)PubMed: 7899523Connolly,K.M., Wojciak,J.M. and Clubb,R.T.Site-specific DNA binding using a variation of the double strandedRNA binding motifNat. Struct. Biol. 5 (7), 546-550 (1998)PubMed: 9665166","","Fri Jan 11 08:19:12 2002","1","","16","SMU.1032","" "SMu0943","984043","982973","1071","ATGAGACGTGAACTCTTACTTGAAAAAATTGACGAACTTAAGGAACTTATGCCTTGGTATGTGCTAGAGTATTATCAATCTAAATTGACAGTTCCTTATAGTTTTACGACTTTATATGAATACTTAAAAGAATATCGGCGTTTCTTTGAATGGTTAATTGATTCTGGTGTCTCTAATGCGAATAAACTTGCTGATATTCCGCTGGAAACTTTGGAGCATCTTAGTAAAAAAGATATGGAATCCTTTATTCTCTATTTACGAGAACGAACTCTTTTAAACACTAAAAACAAACGTCAAGGTGTTTCTCAGACAACGATAAACCGCACACTTTCAGCCTTATCAAGCCTTTATAAATACTTGACTGAGGAAGTTGAAAATGCTGATGGTGAACCTTATTTTTATCGAAATGTCATGAAAAAGGTATCAACTAAAAAGAAAAAGGAAACATTGGCCGCACGAGCTGAGAATATTAAACAAAAGCTCTTTTTAGGCAATGAAACAATGGAATTTTTAGAATATGTGGATTGTGAATATGAACACAAACTTTCTAAACGCGCTCTTTCCTCTTTTCGAAAAAATAAAGAAAGAGATTTGGCAATTATTGCTTTGCTGCTAGCATCTGGAGTTCGTCTTTCAGAGGCTGTTAACCTTGATCTTAAGGATGTTAATCTCAATATGATGATTATTGAAGTTACCCGTAAGGGCGGCAAACACGATTCGGTTAATGTCGCTGGTTTCGCTAAACCTTATTTAGAAAACTACATTACTATCAGACGGGGGCGCTACAAGGCTAAAAAGACTGATCTAGCTTTCTTTTTATCCGAATATCGTGGTGTTCCTAATCGCATGGATGCTTCTTCTATTGAAAAAATGGTTGCTAAATATTCGCAAGATTTCAAAATCCGCGTCACTCCCCACAAACTAAGACACACGCTTGCAACTAGATTATACGATGCTACCAAATCACAAGTTTTGGTCAGTCATCAATTAGGTCATGCTTCTACTCAAGTAACAGACCTTTATACTCATATCGTTAATGATGAACAAAAAAATGCTTTAGATAAATTATAA","10.20","13.91","41579","MRRELLLEKIDELKELMPWYVLEYYQSKLTVPYSFTTLYEYLKEYRRFFEWLIDSGVSNANKLADIPLETLEHLSKKDMESFILYLRERTLLNTKNKRQGVSQTTINRTLSALSSLYKYLTEEVENADGEPYFYRNVMKKVSTKKKKETLAARAENIKQKLFLGNETMEFLEYVDCEYEHKLSKRALSSFRKNKERDLAIIALLLASGVRLSEAVNLDLKDVNLNMMIIEVTRKGGKHDSVNVAGFAKPYLENYITIRRGRYKAKKTDLAFFLSEYRGVPNRMDASSIEKMVAKYSQDFKIRVTPHKLRHTLATRLYDATKSQVLVSHQLGHASTQVTDLYTHIVNDEQKNALDKL","982987","","conserved hypothetical protein (possible integrase/recombinase)","Cytoplasm","Matches in gapped BLAST to an unknown and integrase/recombinase. Residues 1-356 are 93% similar to previously published sequence gi|15675163| from S.mutans.Residues 1-356 are 78% similar to integrase/recombinase gi|15675163| from Streptococcus pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0978 (1e-164).","

InterPro
IPR002104
Domain

Integrase, catalytic core, phage
PF00589	$\"[191-351]T$	Phage_integrase

InterPro
IPR004107
Domain

Integrase, N-terminal SAM-like, phage
PF02899	$\"[63-124]T$	Phage_integr_N

InterPro
IPR010998
Domain

Integrase, Lamba-type, N-terminal
SSF47823	$\"[17-123]T$	L_intgrse_like_N

InterPro
IPR011010
Domain

DNA breaking-rejoining enzyme, catalytic core
SSF56349	$\"[172-354]T$	DNA_brk_join_enz

InterPro
IPR013762
Domain

Integrase-like, catalytic core, phage
G3DSA:1.10.443.10	$\"[196-354]T$	Phage_intgr_like

","BeTs to 13 clades of COG0582COG name: IntegraseFunctional Class: LThe phylogenetic pattern of COG0582 is aMtK-qvcEBRHUJ---LINXNumber of proteins in this genome belonging to this COG is 4","***** IPB002104 (Phage integrase family) with a combined E-value of 7.9e-07. IPB002104A 306-320 IPB002104B 330-341","Residues 303-351 are 87% similar to a (INTEGRASE COMPLETE DNA PROTEOME) protein domain (PD000437) which is seen in Q9CG78_LACLA.Residues 239-302 are identical to a (PROTEOME COMPLETE INTEGRASE-RECOMBINASE) protein domain (PD412800) which is seen in O69155_STRMU.Residues 196-237 are identical to a (COMPLETE PROTEOME INTEGRASE/RECOMBINASE) protein domain (PD000548) which is seen in O69155_STRMU.Residues 17-195 are 94% similar to a (PROTEOME COMPLETE PXO1-132 PLASMID) protein domain (PD106382) which is seen in O69155_STRMU.Residues 303-356 are identical to a (DOMAIN OF UNKNO N) protein domain (PD382571) which is seen in O69155_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jan 10 16:30:43 2002","Fri Jan 3 15:33:29 2003","Tue Oct 15 10:41:00 2002","Thu Jan 10 16:27:24 2002","Thu Jan 10 16:27:24 2002","Thu Jan 10 16:27:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0943 is paralogously related (blast p-value < 1e-3) to SMu0942, a predicted integrase.","Tue Jan 29 09:52:53 2002","Thu Jan 10 16:27:24 2002","pdb|1A0P| Site-Specific Recombinase, Xerd 64 3e-011","SMU.1034c","","Residues 178 to 351 (E-value = 1.3e-16) place SMu0943 in the Phage_integrase family which is described as Phage integrase family (PF00589)","Fri Jan 3 15:33:29 2003","24379472","","Cvitkovitch,D.G., Gutierrez,J.A., Behari,J., Youngman,P.J.,Wetz,J.E., Crowley,P.J., Hillman,J.D., Brady,L.J. and Bleiweis,A.S.Tn917-lac mutagenesis of Streptococcus mutans to identifyenvironmentally regulated genesFEMS Microbiol. Lett. 182 (1), 149-154 (2000)PubMed: 10612747","","Tue Jan 29 10:04:57 2002","","1","","","SMU.1034c","349" "SMu0944","984162","985043","882","TTGTCCAAACGATATGGACAACAATTAGCACTTGATAATGTTAATCTTACCATTCAAAAAGGTGAGATTTATGGGCTAATTGGTAAAAATGGTGCAGGTAAGACAACTCTCATCAAAGTCATTACAAAGCTTATTCAACCAAGTCAGGGAAGTGTTTCAGTCTTTGGTTCTAGCACCCAGAGCGAATGGACACACGCTCTTAAGCGTGTCGGTTCTGTGATTGAGACACCTGTTGCACTTAATCATTTGACTGCCCGACAAAATCTGCACTACTACTGCAAGGCACGGCATGTTCCTAATGCTGACAAAGTGATTGACGAAAGTTTAACGCTGGTTGGCCTTACCAATACAGGTAAGAAAAAATTTCGTGGTTTTTCACTTGGTATGAAACAGCGTCTGGGTATAGCTATAGCTTTGATTGTCAAACCAGATTTTCTTATCTTAGACGAACCAATTAATGGCTTGGATCCCGTGGCGATCAAAGAATTTCGGCACATGATTAAGAAACTTAACGAAGAACACGACATGACAGTGATTATTTCCAGTCATATCCTATCTGAGCTTTATCAAGTGGCCACTAAGTTCGGTATTATTGAGAATGGTCGTATTATCAAGGAAATTAGCAAGGCTGATTTTGATACCCAAAGCGAAGACTATATCGTTTTAAAGACCAGTCATATCAATGAAGCCAGCCAAATTCTTCAGGATCAAATGAATTATCGTATTAAGGTCACTAACGCGGACAATGAAATTCATGTGTTCGGACAATCTCATAGTATCAAAGGCATTGTCAAAGAACTAGTTGCAAATGCTGTTGATATTGACGAAATCTACTACAAACGCCAAGATTTAGAAGATTACTTCACACAAATTGTAGAATAA","8.40","3.37","32888","MSKRYGQQLALDNVNLTIQKGEIYGLIGKNGAGKTTLIKVITKLIQPSQGSVSVFGSSTQSEWTHALKRVGSVIETPVALNHLTARQNLHYYCKARHVPNADKVIDESLTLVGLTNTGKKKFRGFSLGMKQRLGIAIALIVKPDFLILDEPINGLDPVAIKEFRHMIKKLNEEHDMTVIISSHILSELYQVATKFGIIENGRIIKEISKADFDTQSEDYIVLKTSHINEASQILQDQMNYRIKVTNADNEIHVFGQSHSIKGIVKELVANAVDIDEIYYKRQDLEDYFTQIVE","985051","For other components see SMu0945 (MSD1). ","ABC transporter ATP-binding protein homolog","Membrane, Cytoplasm","Matches in gapped BLAST to ABC transporter ATP-binding protein homolog. Residues 1-283 are 99% similar to a previously published sequence in S.mutans (gi3152919).Similar to a mutII mutF from another mutans strain (GI:4322366).Residues 1-292 are 43% similar to the protein from Clostridium acetobutylicum (gi15894148).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1980 (6e-30).","

InterPro
IPR003006
Family

Immunoglobulin/major histocompatibility complex
PS00290	$\"[91-97]?$	IG_MHC

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[125-167]T$	Q8DUA8_STRMU_Q8DUA8;
PF00005	$\"[21-201]T$	ABC_tran
PS50893	$\"[1-225]T$	ABC_TRANSPORTER_2
PS00211	$\"[125-139]?$	ABC_TRANSPORTER_1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[20-205]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-216]T$	no description
PTHR19222	$\"[1-215]T$	ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF16	$\"[1-215]T$	ABC TRANSPORTER

","BeTs to 11 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.3e-23. IPB001140A 10-56 IPB001140B 122-160 IPB001140C 177-206","Residues 1-204 are 23% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 11-212 are 26% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD313900) which is seen in Q9WZT4_THEMA.Residues 11-56 are 56% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in O66254_ACTAC.Residues 125-166 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9KEN4_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 13:24:17 2002","Fri Jan 11 08:26:00 2002","Tue May 3 12:43:56 2005","Fri Jan 11 08:26:00 2002","Fri Jan 11 08:26:00 2002","Fri Jan 11 08:26:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0944 is paralogously related (blast p-value < 1e-3) to SMu0596, SMu1649, SMu1050, SMu0950, SMu0390, SMu0335, SMu1003, SMu0216, SMu0976, SMu0849, SMu0418, SMu1920, SMu0374, SMu1762, SMu1518, SMu0235, SMu1093, SMu0971, SMu0666, SMu1023, SMu0218, SMu0884, SMu1380, SMu0594, SMu1288, SMu0517, SMu1949, SMu1517, SMu1036, SMu1950, SMu0752, SMu0731, SMu1545, SMu1757, SMu1210, SMu1410, SMu1001, SMu0907, SMu1246, SMu1231, SMu1068, SMu1811, SMu1079, SMu0916, SMu0786, SMu0164, SMu0258, SMu1959, SMu0836, SMu1037, SMu0475, SMu0823, SMu1710, SMu1316, SMu0234, SMu1428, SMu0805, SMu1751, SMu0476, SMu0987, SMu0825, SMu0224, SMu0824, SMu1724, SMu1306, SMu1064, SMu0837, SMu1202, SMu0729, SMu1065, SMu0986, and SMu0024 all with ATP-binding capabilities.","Tue Jan 29 10:07:39 2002","Tue May 3 12:43:56 2005","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 92 8e-020pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 79 6e-016","SMU.1035","","Residues 21 to 201 (E-value = 6.9e-49) place SMu0944 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Jan 11 08:26:00 2002","24379473","","Cvitkovitch,D.G., Gutierrez,J.A., Behari,J., Youngman,P.J.,Wetz,J.E.,Crowley,P.J., Hillman,J.D., Brady,L.J. Tn917-lac mutagenesis of Streptococcus mutans to identifyenvironmentally regulated genesFEMS Microbiol. Lett. 182 (1), 149-154 (2000)PubMed: 10612747Qi,F., Chen,P. and Caufield,P.W.Functional analyses of the promoters in the lantibiotic mutacin IIbiosynthetic locus in streptococcus mutansAppl. Environ. Microbiol. 65 (2), 652-658 (1999)PubMed: NOT_FOUND","Podlesek,Z., Comino,A., Herzog-Velikonja,B., Zgur-Bertok,D.,Komel,R. and Grabnar,M.Bacillus licheniformis bacitracin-resistance ABC transporter:relationship to mammalian multidrug resistanceMol. Microbiol. 16 (5), 969-976 (1995)PubMed: 7476193","Tue Apr 2 14:56:50 2002","Fri Jan 11 08:31:01 2002","1","","","SMU.1035","" "SMu0945","985064","985807","744","ATGTTACACACAATTCAAGCTGATTTCTATCGTCTATTTCACTCCAAAGGTTTTTGGATTTCAGAATTTTTTCTAATATTAAATATTATTTCTGGTGTTTTTTTTGGAGATACAGGGCACGTTGGTATCCAGCTTCCACAAAAAGTAAAAACTACTTGGACTGGTTTTAAAGCTCTTGTCAATTGCTCGAATAATATTTCTACTACAGTGTTGTTTATCTTAATTATTATTGCTATCGTTGTTGGTGTGGATTTAAATCAAAAATTATATAAAAATAGTATTACTTGCGGTGTGTCGCGAACCGGTTATTTCTTTGCGAAAGCTTCTGTCATTATTGCTATCTCATTTAGTCAGTTTATCCTCTCATATGCACTAGCTTTCATTTTGGGAACAATCGTTCATGGTCTGGGTACAGCACCTCATAATTTCGCTGCACATTTTGCGGTAACAGTCCTTATCCAACTACTATGCAGTATTGCATGGGCCAGCATCGCTACCTTTGCTCTTTATATGACTCACTCAATTGTAGCTATCTTTGTAAGTTTTATTCTTGGGACTGCCGTCTTGGGCCTCCCTACCGTTTTCTTCCCTAAAATAGAACTATTTAAGTACTTTGGCTTAAATTTCAACTTTGTCCTTGCAAGTGATGCAACTGTTGCACAAAATTCGGCTTTAGTTGCTCTCGGATTTATCGTCATCTTTGCATTATTTGGTTTAATTATTTTTAAAAAGCAAGACTTATAA","10.00","7.52","27084","MLHTIQADFYRLFHSKGFWISEFFLILNIISGVFFGDTGHVGIQLPQKVKTTWTGFKALVNCSNNISTTVLFILIIIAIVVGVDLNQKLYKNSITCGVSRTGYFFAKASVIIAISFSQFILSYALAFILGTIVHGLGTAPHNFAAHFAVTVLIQLLCSIAWASIATFALYMTHSIVAIFVSFILGTAVLGLPTVFFPKIELFKYFGLNFNFVLASDATVAQNSALVALGFIVIFALFGLIIFKKQDL","985815","For other components see SMu0944 (NBD1). ","conserved hypothetical protein ","Membrane, Cytoplasm","This is a potential membrane spanning permease. Similr to several Ssan proteins, e.g. Ssan0411.SMu0945 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001991
Family

Sodium:dicarboxylate symporter
PR00173	$\"[69-89]T$ $\"[222-244]T$	EDTRNSPORT

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[151-292]T$	ATP_bd_ATPase
PF02518	$\"[236-292]T$	HATPase_c
SM00387	$\"[190-292]T$	HATPase_c
SSF55874	$\"[151-292]T$	ATP_bd_ATPase

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[82-145]T$	HisKA
SM00388	$\"[82-145]T$	HisKA

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[89-292]T$	HIS_KIN

InterPro
IPR008358
Family

Lantibiotic regulatory protein
PR01780	$\"[91-107]T$ $\"[247-262]T$	LANTIREGPROT

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[17-84]T$	Homeodomain_like

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[72-141]T$	His_kin_homodim

noIPR
unintegrated

unintegrated
PTHR23283	$\"[87-292]T$	PTHR23283
PTHR23283:SF23	$\"[87-292]T$	PTHR23283:SF23

","BeTs to 12 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 10:57:30 2002","Tue Jan 8 11:51:23 2002","Tue Oct 15 10:42:29 2002","Fri Jan 11 08:36:16 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0946 is paralogously related (blast p-value < 1e-3) to SMu1047, SMu0919, SMu1652, SMu0602, SMu1031, SMu0842, SMu1378, SMu0440, and SMu1740, all predicted histidine kinases.","Thu Mar 21 10:04:22 2002","","No significant hits to the NCBI PDB database.","SMU.1037c","","Residues 82 to 145 (E-value = 7.6e-05) place SMu0946 in the HisKA family which is described as His Kinase A (phosphoacceptor) domain (PF00512)","Tue Jan 8 11:51:23 2002","24379475","","","Lau PC, Wang Y, Patel A, Labbe D, Bergeron H, Brousseau R,Konishi Y, Rawlings M.A bacterial basic region leucine zipper histidine kinase regulating toluene degradation.Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1453-8.PMID: 9037074 ","","Fri Jan 11 09:18:11 2002","1","","","SMU.1037c","" "SMu0947","987425","986733","693","ATGGCACGTATTTTACAAATTGAAGATAATAATGATATCCAGAAAATTTTACGAGACTTTTTTTCAGAAGAGCATGAGGTAATCCAAGCATACTCAGGAACCGAGGGCTTGCGGTTATTTGAATCGGAAAATATTGACCTAGTTCTTTTAGACATTATGCTGCCTGGAAAAAGCGGTGAACAAGTTCTTCAAGAAATTCGCAAAGTTAGCTCTGTTCCCATTATCATGCTGACTGCTCTTAGTGATAAGCAGATGATCAGTCAATATTTGCTTGCAGGTGCTAACGATTATATCGTCAAACCTTTTAATCTCGAAGAAGTTTATGCACGGGTGACAGTTCAACTACGTAGTGTAACAAAAAGCCACAATCCAGCAACTACTAAACAGACGGCTTTGTCAATTAAAAATATCACTGTCAATCCCGATACTTTTGAAATTTCTTATTTAGAAAAATCTGTACGATTAGGAAAGAAAGAATTTCAGATTTTACATGCCTTGCTTCAGTACCCTAAGAAAATATTTACCAAAGAAGACTTGTATGAATCGGTTTGGAAAGAGCCTTACTTACCCGGTGATAATACTTTAAATGCGCAGTTAAGCAATCTTCGCAGGAAACTCGCACAGGTTGATGATAGCACAGACTACATTGAAACAATCTGGGGATTAGGTGTTCGACTAAAAGGAGAAGATTGA","5.10","-5.26","26292","MARILQIEDNNDIQKILRDFFSEEHEVIQAYSGTEGLRLFESENIDLVLLDIMLPGKSGEQVLQEIRKVSSVPIIMLTALSDKQMISQYLLAGANDYIVKPFNLEEVYARVTVQLRSVTKSHNPATTKQTALSIKNITVNPDTFEISYLEKSVRLGKKEFQILHALLQYPKKIFTKEDLYESVWKEPYLPGDNTLNAQLSNLRRKLAQVDDSTDYIETIWGLGVRLKGED","986747","","response regulator","Cytoplasm","Several matches in gapped BLAST to response regulator.Residues 1-230 are 34% similar to a previously published sequence from S.mutans (gi|14600271|).Residues 4-227 are 39% similar to gi|15894147| from Clostridium acetobutylicum. Residues 3-226 are 37% similar to gi|15613383| from Bacillus halodurans. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0123 (4e-33).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[3-116]T$	Response_reg
PF00072	$\"[2-112]T$	Response_reg
SM00448	$\"[2-111]T$	REC
PS50110	$\"[3-115]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[151-228]T$	Trans_reg_C
PF00486	$\"[150-226]T$	Trans_reg_C

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-192]T$	CheY_like

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[132-226]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[3-128]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[3-120]T$	PTHR23283
PTHR23283:SF21	$\"[3-120]T$	PTHR23283:SF21

","BeTs to 8 clades of COG0745COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG0745 is -----QVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 10","***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 2.2e-43. IPB001867A 46-59 IPB001867B 73-117 IPB001867C 153-184 IPB001867D 212-226***** IPB001789 (Response regulator receiver domain) with a combined E-value of 2.6e-12. IPB001789B 46-59 IPB001789C 93-102","Residues 3-116 are 46% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in YRKP_BACSU.Residues 132-226 are 37% similar to a (DNA-BINDING TRANSDUCTION SENSORY TRANSCRIPTION) protein domain (PD000329) which is seen in Q9KEN2_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 09:23:18 2002","Tue Jan 8 11:52:23 2002","Tue Oct 15 10:42:53 2002","Fri Jan 11 09:21:13 2002","Tue Jan 8 11:52:23 2002","Tue Jan 8 11:52:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0947 is paralogously related (blast p-value < 1e-3) to SMu1379, SMu1048, SMu0601, SMu1032, SMu1748, SMu1653, SMu0918, SMu0841, SMu1406, SMu1782, and SMu0525, all predicted response regulators. ","Wed Feb 13 08:29:38 2002","Tue Jan 8 11:52:23 2002","pdb|1F51|E Chain E, A Transient Interaction Between Two Phospho... 67 2e-012pdb|1SRR|A Chain A, Crystal Structure Of A Phosphatase Resistan... 67 2e-012pdb|1FSP| Nmr Solution Structure Of Bacillus Subtilis Spo0f P... 66 5e-012","SMU.1038c","","Residues 2 to 119 (E-value = 6.1e-31) place SMu0947 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 150 to 226 (E-value = 1.5e-20) place SMu0947 in the Trans_reg_C family which is described as Transcriptional regulatory protein, C terminal (PF00486)","Tue Jan 8 11:52:23 2002","24379476","","","Casadewall,B. and Courvalin,P.Characterization of the vanD glycopeptide resistance gene clusterfrom enterococcus faecium BM4339J. Bacteriol. 181 (12), 3644-3648 (1999)PubMed: 10368136","Fri Jan 11 09:23:18 2002","Fri Jan 11 09:26:06 2002","1","","","SMU.1038c","" "SMu0948","988391","987558","834","ATGACAGAATCATCTATTAATCTTTTGTTTTCAATTGATAATCGCTTTGTTGAACAGTTCAAAGTCACCTTATATTCTTTGTATCAAAATACTTCCAATAAAAACTTAAAGATTTATATGTTACAAAAGGAGTTATTAGCCGATCATAAAGCAATTGAGCGTTTTTGTTATCAATTAGGACTGTCTTATAAACCAATTATTATTGGTGAGGAGGACTTCAAAGATGCTCCAGTTAGCGATCGTTATCCAGAAACCATTTATTACCGCCTCTTAGCTCAAGACTATCTTCCTAAAAGCCTAGATAAAATCCTTTATTTAGATGCCGATATTCTCTGTCTTAATGATATAGCCCCTCTCTATCAAATGGATATGAAAAATTATATTTATGCAGCCGCTAGTCATGTATCAGATAAAAGTATTACTGATATTGTCAACAAACTACGCTTGAATAATTTTGAAGCAGAGGGTTATTTCAATTCTGGTGTTCTTTTGATGAATTTAGAACAATGCCGGCAGAAGATTAAACCACAAGATATTATGAATTATATTTCTAGAAAAGGAAATACCCTATTATTACCGGATCAAGACGTTCTCAATGCACTGTATGGTACGAAAACGCATCTTATCCCTGATGAAATTTATAATTATGATGCTAGATATAATATCATCTATTTTACTCGTAGTCTTGGAGAATGGGATCTTGATTGGGTCATTGAAAATACGGTTTTCTTACATTTTTGTGGTAAAGATAAACCTTGGAGAAAAGACTACAAGGGACGCTATGCAGCTCTGTATAAACATTATCAGCATAGAGTTAAAATATTAGAAAAATAA","7.10","0.26","32766","MTESSINLLFSIDNRFVEQFKVTLYSLYQNTSNKNLKIYMLQKELLADHKAIERFCYQLGLSYKPIIIGEEDFKDAPVSDRYPETIYYRLLAQDYLPKSLDKILYLDADILCLNDIAPLYQMDMKNYIYAAASHVSDKSITDIVNKLRLNNFEAEGYFNSGVLLMNLEQCRQKIKPQDIMNYISRKGNTLLLPDQDVLNALYGTKTHLIPDEIYNYDARYNIIYFTRSLGEWDLDWVIENTVFLHFCGKDKPWRKDYKGRYAALYKHYQHRVKILEK","987572","","UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase","Cytoplasm","Matches in gapped BLAST to hypothetical protein and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Residues 4-269 are 56% similar to hypothetical protein gi14317885 from S.criceti. Residues 2-255 are 26% similar to UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferasegi3132871 from E.coli. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0812 (3e-88).","

InterPro
IPR002495
Family

Glycosyl transferase, family 8
PF01501	$\"[7-257]T$	Glyco_transf_8

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[6-270]T$	G3DSA:3.90.550.10
SSF53448	$\"[6-271]T$	SSF53448

","BeTs to 4 clades of COG1442COG name: Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferasesFunctional Class: MThe phylogenetic pattern of COG1442 is --------Eb-hUJ------xNumber of proteins in this genome belonging to this COG is 1","***** IPB002495 (Glycosyltransferase family 8) with a combined E-value of 1.8e-19. IPB002495A 108-119 IPB002495B 156-166 IPB002495C 194-209 IPB002495D 240-254","Residues 149-273 are 28% similar to a (TRANSFERASE LIPOPOLYSACCHARIDE) protein domain (PD002473) which is seen in GSPA_BACSU.Residues 58-133 are 36% similar to a (TRANSFERASE LPS GLYCOSYLTRANSFERASE) protein domain (PD186321) which is seen in Q9R9D1_ECOLI.Residues 66-131 are 40% similar to a (TRANSFERASE GLYCOSYL PROTEOME) protein domain (PD186166) which is seen in Q9CLS0_PASMU.Residues 3-128 are 26% similar to a (LIPOPOLYSACCHARIDE TRANSFERASE) protein domain (PD407656) which is seen in RFAJ_SALTY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 09:37:00 2002","Tue Jan 29 10:17:53 2002","Wed Sep 27 13:53:42 2006","Fri Jan 11 09:36:10 2002","Fri Jan 11 09:36:10 2002","Fri Jan 11 09:36:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0948 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 09:37:00 2002","","No significant hits to the NCBI PDB database.","SMU.1039c","","Residues 7 to 257 (E-value = 2.6e-28) place SMu0948 in the Glyco_transf_8 family which is described as Glycosyl transferase family 8 (PF01501)","Fri Jan 11 09:36:10 2002","24379477","","","Heinrichs,D.E., Monteiro,M.A., Perry,M.B. and Whitfield,C.The assembly system for the lipopolysaccharide R2 core-type ofEscherichia coli is a hybrid of those found in Escherichia coliK-12 and Salmonella enterica. Structure and function of the R2 Waak and Waal homologsJ. Biol. Chem. 273 (15), 8849-8859 (1998)PubMed: 9535865Heinrichs,D.E., Yethon,J.A. and Whitfield,C.Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella entericaMol. Microbiol. 30 (2), 221-232 (1998)PubMed: 9791168","","Fri Jan 11 09:38:14 2002","1","","","SMU.1039c","" "SMu0949","989162","988407","756","ATGGCAGAAACAGTATTGATTACAGGTGCTTCGGCGGGTTTTGGCAAGGCTATGACTGAAACTTTTATTCATTCTGGTTACCGTGTTATCGGAGCAGCCAGACGCTTAGAAAAACTTGGAAAACTTAGAGAAGCCTTAGGGGAACATTTTTATCCTTTGCAATTAGATATGACTGATACATCCTCTATTAACAAGGCTTTAGCGAATTTACCTAAAGAATGGTCAAAAATTGAACTCCTTGTTAACAATGCAGGACTGGCTTTAGGTCTTGATAAGGCTTATGAGGCTAATTTCAAGGATTGGGAAACCATGATTGCGACTAATATCATTGGTCTGACTTATTTAACCCGTCAAATTTTGCCTGATATGGTTGCAAGAAAATCAGGGCATATTATCAATATCGGCTCGACTGCAGGTACTTATCCTTATCCGGGCGGTAATGTTTATGGTGCCAGCAAAGCCTTTGTTAAGCAATTCAGTTTGAACCTACGAGCGGATTTGGCTGGTACTAAAGTGCGAGTGACCAACATTGAACCCGGACTTTGTGGTAGCACAGAATTCTCGACCATTCGTTTCAAAGGAGATAAGAAGCGTGCTGAACAGCTATATGAAGGTGCTCACAGCATTCAGCCGCAAGATATTGCCAATGCTGTTCTCTGGACTTTTCAACAACCTAAACACGTTAATATCAATCGTATTGAAATTATGCCAACATCGCAAAGTTTCGGTCCTCAGCCAGTTGAAAGGGACTATTAG","9.80","5.16","27652","MAETVLITGASAGFGKAMTETFIHSGYRVIGAARRLEKLGKLREALGEHFYPLQLDMTDTSSINKALANLPKEWSKIELLVNNAGLALGLDKAYEANFKDWETMIATNIIGLTYLTRQILPDMVARKSGHIINIGSTAGTYPYPGGNVYGASKAFVKQFSLNLRADLAGTKVRVTNIEPGLCGSTEFSTIRFKGDKKRAEQLYEGAHSIQPQDIANAVLWTFQQPKHVNINRIEIMPTSQSFGPQPVERDY","988421","","oxidoreductase, short-chain dehydrogenase/reductase","Cytoplasm","Matches in gapped BLAST to oxidoreductase, short-chain dehydrogenase/reductase. Residues 5-247 are 56% similar to gi|15676819| from N.meningitidis. Residues 1-243 are 37% similar to the protein gi|15901734| from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1091 (3e-79).","

InterPro
IPR002198
Family

Short-chain dehydrogenase/reductase SDR
PR00080	$\"[75-86]T$ $\"[129-137]T$ $\"[149-168]T$	SDRFAMILY
PTHR19410	$\"[4-239]T$	ADH_short_C2
PF00106	$\"[3-168]T$	adh_short
PS00061	$\"[136-164]T$	ADH_SHORT

InterPro
IPR002347
Family

Glucose/ribitol dehydrogenase
PR00081	$\"[4-21]T$ $\"[75-86]T$ $\"[123-139]T$ $\"[149-168]T$ $\"[170-187]T$ $\"[204-224]T$	GDHRDH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[3-237]T$	G3DSA:3.40.50.720
PTHR19410:SF42	$\"[4-239]T$	PTHR19410:SF42
SSF51735	$\"[1-246]T$	SSF51735

","BeTs to 6 clades of COG0300COG name: Short-chain dehydrogenases of various substrate specificitiesFunctional Class: RThe phylogenetic pattern of COG0300 is ----y--ceBRhuj-------Number of proteins in this genome belonging to this COG is 3","***** IPB002198 (Short-chain dehydrogenase/reductase (SDR) superfamily) with a combined E-value of 2.2e-15. IPB002198 129-164","Residues 56-126 are 45% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME) protein domain (PD126102) which is seen in Q9JUV3_NEIMA.Residues 129-176 are 89% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD003795) which is seen in Q9CN62_PASMU.Residues 5-51 are 63% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME) protein domain (PD058480) which is seen in Q9JUV3_NEIMA.Residues 179-241 are 68% similar to a (OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD006579) which is seen in YDFG_HAEIN.Residues 7-138 are 28% similar to a (COMPLETE PROTEOME 4-EPIMERASE REDUCTASE UDP-GLUCOSE NAD) protein domain (PD000038) which is seen in Q9X890_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 09:55:25 2002","Fri Jan 11 09:55:25 2002","Tue Oct 15 10:47:12 2002","Fri Jan 11 09:52:02 2002","Fri Jan 11 09:52:02 2002","Fri Jan 11 09:52:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0949 is paralogously related (blast p-value < 1e-3) to SMu1340, a predicted oxidoreductase, SMu0278, a predicted sorbitol-6-phosphate 2-dehydrogenase, SMu1586, a predicted beta-ketoacyl-ACP reductase, SMu1919, a predicted oxidoreductase (probable short-chain dehydrogenase) and SMu1207, a predicted acetoin reductase.","Mon Jan 14 09:29:56 2002","Fri Jan 11 09:52:02 2002","pdb|1I01|A Chain A, Crystal Structure Of Beta-Ketoacyl [acyl Ca... 85 6e-018","SMU.1040c","","Residues 5 to 239 (E-value = 5.9e-62) place SMu0949 in the adh_short family which is described as short chain dehydrogenase (PF00106)","Fri Jan 11 09:52:02 2002","24379478","","","","","","1","","","SMU.1040c","808" "SMu0950","989323","990069","747","ATGATTAGATTTGAGCATATTTCTAAAATTTATGGAACAACTGAGGCACTTAGTGACCTTAATTTGACTATAGAAAACGGTGAAATTTTTGGGTTGATTGGCCATAACGGTGCTGGGAAAACGACGACTATCAGTTTGTTGACATCAATTATTGAAGCGAGTTATGGCAATATCTTTATAGATGATTTCAAATTAACAGAACATCGTGATGCGATAAAAAAACGAATCGCTTATGTACCTGATTCTCCCGATATTTTCCTAAATCTAACAGCTTATGAATATTGGCATTTTCTATCAAAGATTTATGGCGTTGAAGAAGAAATTGCCCAAGAGCGAATGACTAAATTAGCTAACCTTTTTGATATTTCCGATAGACAATTTGAAACCATCGAGAGCTTTTCACATGGAATGCGACAAAAAGTTATTGTTATTGGTGCTCTCATTCCAAATCCAGATATTTGGATTTTAGATGAACCATTGACAGGACTTGACCCACAGGCCTCTTATGATTTGAAAGAAATGATGAAAAAGCATGCTCAAGATGGCAATACGGTCCTCTTTTCAACCCATGTTTTATCAGTTGCTGAACAATTGTGCGATCGTATTGGTATTCTTAGACATGGTAAACTTATTTTCGTTGGTACTTTAGAAGAATTAAAGGCCAATTATCCGAATCAAGATTTAGAAAGTATCTACCTTGAGTTAGCTGGACGAAAGGAAGAATCAAAGGTAGGTGATGAGGAATGA","4.70","-14.10","28096","MIRFEHISKIYGTTEALSDLNLTIENGEIFGLIGHNGAGKTTTISLLTSIIEASYGNIFIDDFKLTEHRDAIKKRIAYVPDSPDIFLNLTAYEYWHFLSKIYGVEEEIAQERMTKLANLFDISDRQFETIESFSHGMRQKVIVIGALIPNPDIWILDEPLTGLDPQASYDLKEMMKKHAQDGNTVLFSTHVLSVAEQLCDRIGILRHGKLIFVGTLEELKANYPNQDLESIYLELAGRKEESKVGDEE","990077","For other components see SMu0951 (MSD1 and MSD2).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Numerous matches in gapped BLAST to ABC transporter, ATP-bindingproteins.Residues 1-244 are 33% similar to a previously published sequence from S.mutans (gi|3152919|). Residues 1-243 are 69% similar to gi|15675537| fromS.pyogenes. Residues 1-241 are 58% similar to gi|15901235| fromS.pneumoniaeThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0280 (1e-99).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[133-175]T$	ABC_transporter
PF00005	$\"[27-208]T$	ABC_tran
PS00211	$\"[133-147]?$	ABC_TRANSPORTER_1
PS50893	$\"[2-232]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-208]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-223]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-235]T$	PTHR19222
PTHR19222:SF16	$\"[2-235]T$	PTHR19222:SF16
SSF52540	$\"[1-222]T$	SSF52540

","BeTs to 12 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.3e-21. IPB001140A 16-62 IPB001140B 130-168","Residues 17-220 are 18% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 177-218 are 50% similar to a (PROTEOME ATP-BINDING COMPLETE ABC) protein domain (PD403704) which is seen in Q9WZQ0_THEMA.Residues 182-223 are 57% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174) which is seen in Q9V0K9_PYRAB.Residues 73-202 are 21% similar to a (AS-48D PLASMID BACE) protein domain (PD034066) which is seen in O53027_ENTFA.Residues 85-211 are 25% similar to a (LACF) protein domain (PD194047) which is seen in Q9RAV2_LACLA.Residues 76-218 are 28% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD398054) which is seen in Q9CDL6_LACLA.Residues 132-175 are 50% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CE51_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 13:25:54 2002","Fri Jan 11 10:04:09 2002","Tue Oct 15 10:47:51 2002","Fri Jan 11 10:01:23 2002","Fri Jan 11 10:01:23 2002","Fri Jan 11 10:01:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0950 is paralogously related (blast p-value < 1e-3) to SMu0374, SMu1649, SMu0944, SMu0596, SMu1003, SMu0976, SMu0335, SMu1093, SMu0216, SMu1518, SMu0418, SMu0884, SMu1950, SMu0731, SMu1920, SMu0390, SMu1050, SMu1762, SMu1517, SMu1210, SMu0666, SMu0517, SMu1380, SMu0971, SMu0218, SMu0907, SMu1949, SMu1410, SMu0594, SMu1428, SMu0849, SMu0235, SMu1079, SMu1288, SMu0475, SMu1710, SMu0805, SMu1023, SMu0258, SMu1757, SMu0234, SMu0752, SMu0916, SMu1036, SMu0164, SMu0836, SMu0786, SMu1001, SMu1068, SMu1959, SMu1037, SMu1246, SMu1231, SMu0476, SMu1064, SMu1065, SMu1811, SMu0825, SMu0987, SMu1751, SMu0837, SMu1724, SMu0986, SMu0024, SMu1316, SMu1545, SMu0823, SMu0729, SMu0224, SMu1686, and SMu1306 all with ATP-binding capabilities.","Tue Jan 15 10:42:22 2002","Fri Jan 11 10:01:23 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 94 2e-020pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 76 4e-015","SMU.1041","","Residues 27 to 208 (E-value = 1.6e-41) place SMu0950 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Jan 11 10:01:23 2002","24379479","","Cvitkovitch,D.G., Gutierrez,J.A., Behari,J., Youngman,P.J.,Wetz,J.E., Crowley,P.J., Hillman,J.D., Brady,L.J.and Bleiweis,A.S.Tn917-lac mutagenesis of Streptococcus mutans to identifyenvironmentally regulated genesFEMS Microbiol. Lett. 182 (1), 149-154 (2000)PubMed: 10612747Qi,F., Chen,P. and Caufield,P.W.Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in streptococcus mutansAppl. Environ. Microbiol. 65 (2), 652-658 (1999)PubMed: 9925596","Yamamoto,H., Uchiyama,S. and Sekiguchi,J.The Bacillus subtilis chromosome region near 78 degrees containsthe genes encoding a new two-component system, three ABCtransporters and a lipaseGene 181 (1-2), 147-151 (1996)PubMed: 8973323","Tue Apr 2 14:58:25 2002","Fri Jan 11 10:06:23 2002","1","","","SMU.1041","631" "SMu0951","990066","991673","1608","ATGAGCTATAGAACTATTTGGGAATTGATAAAAATCAATATTCTCTATTCCAATCCTCAAGCTTTAACGACTGTTCAAAAAAAACGAGAGAAAAACCCTGATAAGCAGATTGCAGCCTATAAAACAGTTTTAAAACAGCAACTCTTCTTACTTATACTCTTTTTATTTGTTTACTCTACCATGTTTTTGGTAGTTGATTATTCCAAATCAAGTGGTTATTTTTCTTTCCAAGTCGCCCTTTTTAGTACTATTGCTATTGTTTCAGGTTTCACAACACTCTTTGCTGTATTTTATGATAGTAATGATACTAAACTCTACCTTCCTTTACCAGTTAAAGAAAAAGAAGTTTATTTAGCTAAATTGATTTCGTCTCAAGGAGGAAGTCTTCCTTTTCTTATGCCTATTATTTCACTTTTTGGAATTGCTTACTGGCAGATGACGCATTCTATTTTATTGGCTATTATAGCGACTATTATTAATTTCTTGCTGCTATTACTTGCTATCAATTGTATCAGCATTATTCTCATCTATTTGATTGGACAAGTTTTGGTCAAGAGTGTACACAAAAAACTGATCTCAACAATTCTAATGTTCTTTTCAACAGCTTTGGCTATCGGAGTACTGTTTTATGTTCAGTTTACTAATCAATCAGTAAATGAGAGTGGTCGGGTTAAAATGATGAGTCTACCTTATTTTAGAGGCTTTCATGATATCGTCATTAATCCCTTTTCAACCGCAAGTCTTTTAAATTTTTGGTTAGGAATCACCATAACTATCATTTTGTTAGTTTTTATTCAACGTACGATTATTTCTCACTATTTTGAACAATTTTTATCCATTCAAGAAGGACAGCCTACTAAGAAAAAGGTTAAATTAAGAAGAAAAGATGTTAGTTTAGCACAAACTCTTCGCAAGCATCATTTAGATACTCTCAAAGATGCGACACTTCTTATCCAAAGTTATTTGATGCCTTTGATTTTTATCATTGCATTTATAGGACCGATTCTTTCATCAGGAAGATCTCTTTTTCAACATATTTCATCTGACTTTTTCGGAATAGCTTTTATTATTGGCATTATTTTGGGAAGCTTTATTGCAACTCCTACTAGTTTTATGGGGGTCGGAATTTCTCTAGAAAAAGAAAATTATACCTTTTTAAAAACTTTACCAATTTCTTTTAAAACATTTTTGAAACAGAAATTCTATTATCTTTTAGCAGTACAAGCTGGTTTCTTAGTCTTTATTTATTTGATAATAGGCCTCTTTTTGTTAAATATTCCAATTATTCTATTAATCAGTTTTATCATTGGAATGGTACTTTCAACTTTTATCTTGGGGGAATTAATGTACTGGCGTGATTATCGTCTTTTAACACTTCATTGGCAAAATGTGGCGCAATTATTTTCAAGAGGTTCAGGCCAGTGGTTCCTTATGGCAGTAATTTTTGGAAATTTACTTATTGGTAGCTTTTTATTAGTATTAGCCATTATTGTTTCTCTTAAAACTTCAGTTTTAGGAGTTGGAATCGTTTTGGTTGTTATGGTGCTACTTCTCTTTGGAGGATTACATTGCTTTATTCAACAAAGATTTTGGAAAAAGTTGATTTAA","10.70","26.06","60847","MSYRTIWELIKINILYSNPQALTTVQKKREKNPDKQIAAYKTVLKQQLFLLILFLFVYSTMFLVVDYSKSSGYFSFQVALFSTIAIVSGFTTLFAVFYDSNDTKLYLPLPVKEKEVYLAKLISSQGGSLPFLMPIISLFGIAYWQMTHSILLAIIATIINFLLLLLAINCISIILIYLIGQVLVKSVHKKLISTILMFFSTALAIGVLFYVQFTNQSVNESGRVKMMSLPYFRGFHDIVINPFSTASLLNFWLGITITIILLVFIQRTIISHYFEQFLSIQEGQPTKKKVKLRRKDVSLAQTLRKHHLDTLKDATLLIQSYLMPLIFIIAFIGPILSSGRSLFQHISSDFFGIAFIIGIILGSFIATPTSFMGVGISLEKENYTFLKTLPISFKTFLKQKFYYLLAVQAGFLVFIYLIIGLFLLNIPIILLISFIIGMVLSTFILGELMYWRDYRLLTLHWQNVAQLFSRGSGQWFLMAVIFGNLLIGSFLLVLAIIVSLKTSVLGVGIVLVVMVLLLFGGLHCFIQQRFWKKLI","991681","For other components see SMu0950 (NBD1) and SMu0951 (MSD2).","conserved hypothetical protein; possible ABC transporter, permease","Membrane, Cytoplasm","This is a potential membrane spanning permease.Limited matches in gapped BLAST to hypothetical proteins:residues 1-534 are 39% similar to S.pyogenes gi15675536 and 23% similar to S.pneumoniae (gi15903280).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0281 (6e-98).","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[117-276]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[48-68]?$ $\"[78-98]?$ $\"[119-139]?$ $\"[145-179]?$ $\"[191-211]?$ $\"[245-265]?$ $\"[320-340]?$ $\"[346-366]?$ $\"[402-422]?$ $\"[428-450]?$ $\"[471-500]?$ $\"[506-526]?$	transmembrane_regions

InterPro
IPR002505
Domain

Phosphate acetyl/butaryl transferase
PF01515	$\"[5-323]T$	PTA_PTB

InterPro
IPR004614
Domain

Phosphate acetyltransferase
TIGR00651	$\"[21-323]T$	pta

InterPro
IPR012147
Family

Phosphate acetyl/butyryltransferase
PIRSF000428	$\"[4-329]T$	P_Ac_trans

noIPR
unintegrated

unintegrated
PTHR23406	$\"[72-325]T$	PTHR23406
PTHR23406:SF3	$\"[72-325]T$	PTHR23406:SF3
SSF53659	$\"[4-331]T$	SSF53659

","BeTs to 10 clades of COG0280COG name: PhosphotransacetylaseFunctional Class: CThe phylogenetic pattern of COG0280 is ------VcEBrH-jgpol--XNumber of proteins in this genome belonging to this COG is 1","***** IPB002505 (Phosphate acetyl/butaryl transferase) with a combined E-value of 1.9e-90. IPB002505A 123-157 IPB002505B 168-190 IPB002505C 200-209 IPB002505D 233-276 IPB002505E 293-325","Residues 28-110 are 39% similar to a (ACYLTRANSFERASE PHOSPHOTRANSACETYLASE) protein domain (PD230075) which is seen in Q9K6A6_BACHD.Residues 21-168 are 27% similar to a (TRANSFERASE ACETYLTRANSFERASE) protein domain (PD214254) which is seen in PTA_BORBU.Residues 114-308 are 71% similar to a (TRANSFERASE PHOSPHATE ACYLTRANSFERASE ACETYLTRANSFERASE) protein domain (PD002789) which is seen in Q9K6A6_BACHD.Residues 111-159 are 75% similar to a (PHOSPHOTRANSACETYLASE ACETYLTRANSFERASE) protein domain (PD334891) which is seen in PTA_BACSU.Residues 20-110 are 48% similar to a (TRANSFERASE PHOSPHATE ACETYLTRANSFERASE COMPLETE) protein domain (PD319787) which is seen in Q9CF22_LACLA.Residues 167-325 are 55% similar to a (ENZYME OXIDOREDUCTASE MALIC) protein domain (PD386668) which is seen in PTA_METTE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 10:15:36 2002","Tue Sep 12 15:22:43 2006","Tue Sep 12 15:22:43 2006","Fri Jan 11 10:13:43 2002","Fri Jan 11 10:13:43 2002","Fri Jan 11 10:13:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0952 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 10:15:36 2002","","No significant hits to the NCBI PDB database.","SMU.1043c","","Residues 5 to 323 (E-value = 4.4e-159) place SMu0952 in the PTA_PTB family which is described as Phosphate acetyl/butaryl transferase (PF01515)","Fri Jan 11 10:13:43 2002","24379481","","","Reinscheid,D.J., Schnicke,S., Rittmann,D., Zahnow,U., Sahm,H.andEikmanns,B.J.Cloning, sequence analysis, expression and inactivation of theCorynebacterium glutamicum pta-ack operon encodingphosphotransacetylase and acetate kinaseMicrobiology 145 (Pt 2), 503-513 (1999)PubMed: 10075432Kakuda,H., Hosono,K., Shiroishi,K. and Ichihara,S.Identification and characterization of the ackA (acetate kinaseA)-pta (phosphotransacetylase) operon and complementation analysisof acetate utilization by an ackA-pta deletion mutant ofEscherichia coliJ. Biochem. 116 (4), 916-922 (1994)PubMed: 7883769","","Fri Jan 11 10:20:57 2002","1","","","SMU.1043c","366" "SMu0953","993676","992786","891","ATGAGGTTTGAATTCATTGCTGATCGAAAAGTAAAAGTTAAAACTTTCTTAAAAAGCCATGATATTTCTAAGACTTTGTTAGCTAAAATCAAATTTAAAGGCGGTCAAATATTAGTAAATGATCAAGAAGAAAATGCTATTTATCTTCTTGATATAGGCGATCGGGTAACTATAATAATTCCCGACGAAGAAGCGCTTGAAACTTTACAGCCCATTAAGCATGATTTGAATATTGTTTATGAAGATGAACATTTTTTAATTTTGGATAAACCTGCTGGTTATGCTAGTATTCCTAGCATCTTACATACCAATACCATAGCCAATTTTGTTAAATATTATTATCTCAAAAAAGATTATCCCAATAAGCAAATCCATATTGTAACAAGGCTTGATAAGGATACTAGCGGTCTTATGCTTTTAGCCAAGCATGGTTATGCTCATGCTAGGCTGGATAAGCAGCTGCAAAAGAAGACCATTAAAAAACGGTATTATGCGCTTGTTTCTGGACAAGGGCAACTGCCTGATCAAGGAGAGATCATCGCTCCTATTGCAAGACCGGAAGATAGTATCATTACACGCTGTGTTCACCCTTCTGGTAAATATGCACATACAAGTTATAAAGTATTAGCTCGTTACGGTGATATCGCCTTGGTTGATATTCAACTTCATACCGGCCGAACTCACCAAATTCGCGTACACTTTGCTCATATTGGTTTTCCCCTTTTAGGAGATGATTTATATGGAGGAGAAATGGGGTATGGTTTAAAAAGACAAGCTCTTCACTGCCATTTTTTGTCTTTTGTGGATCCTTTTTCCAAAGAACATAAGCAGTACAATAGTTCCTTGACAGAAGACCTTGATAGCGTTATCATAGATTTACAAAAACATTAG","9.00","7.00","33831","MRFEFIADRKVKVKTFLKSHDISKTLLAKIKFKGGQILVNDQEENAIYLLDIGDRVTIIIPDEEALETLQPIKHDLNIVYEDEHFLILDKPAGYASIPSILHTNTIANFVKYYYLKKDYPNKQIHIVTRLDKDTSGLMLLAKHGYAHARLDKQLQKKTIKKRYYALVSGQGQLPDQGEIIAPIARPEDSIITRCVHPSGKYAHTSYKVLARYGDIALVDIQLHTGRTHQIRVHFAHIGFPLLGDDLYGGEMGYGLKRQALHCHFLSFVDPFSKEHKQYNSSLTEDLDSVIIDLQKH","992800","For other 'rlu' genes see SMu0580 (rluB); SMu0778 (rluD); SMu1559 (rluB) and SMu1772 (rluD).From Genbank:[gi:2507541]This enzyme is responsible for synthesis of pseudouridine from uracil at two positions in 23S ribosomal RNA .","ribosomal large subunit pseudouridine synthase","Cytoplasm","Several matches in gapped BLAST to pseudouridine synthase: residues 1-293 are 68% similar to the enzyme in S.pyogenes (gi15900967). Residues 13-290 are 51% similar to the protein from Lactococcus lactis (gi15672346).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1093 (1e-123).","

InterPro
IPR006145
Domain

Pseudouridine synthase
PD001819	$\"[124-169]T$	PseudoU_synth
PF00849	$\"[84-236]T$	PseudoU_synth_2

InterPro
IPR006224
Family

Pseudouridine synthase, Rlu
PS01129	$\"[127-141]?$	PSI_RLU

InterPro
IPR006225
Domain

Pseudouridine synthase, RluD
TIGR00005	$\"[4-294]T$	rluA_subfam

noIPR
unintegrated

unintegrated
PTHR10436	$\"[31-293]T$	PTHR10436
SSF55120	$\"[67-286]T$	SSF55120
SSF55174	$\"[7-95]T$	SSF55174

","BeTs to 13 clades of COG0564COG name: Predicted pseudouridylate synthase family 2Functional Class: JThe phylogenetic pattern of COG0564 is ----YqVCEBRHUJGPOLINXNumber of proteins in this genome belonging to this COG is 3","***** IPB000613 (Pseudouridine synthase) with a combined E-value of 8.5e-58. IPB000613A 78-98 IPB000613B 127-166 IPB000613C 224-248 IPB000613D 257-270***** IPB002990 (Pseudouridine synthase, Rlu family) with a combined E-value of 1.5e-51. IPB002990A 78-98 IPB002990B 127-165 IPB002990C 224-248","Residues 13-71 are 54% similar to a (PROTEOME COMPLETE MECA-TENA PSEUDOURIDINE) protein domain (PD112931) which is seen in Q9CIJ3_LACLA.Residues 77-185 are 43% similar to a (SYNTHASE PSEUDOURIDINE COMPLETE PROTEOME RIBOSOMAL) protein domain (PD001819) which is seen in Q9K905_BACHD.Residues 200-274 are 64% similar to a (SYNTHASE PROTEOME COMPLETE PSEUDOURIDINE RIBOSOMAL LARGE) protein domain (PD350148) which is seen in Q9CIJ3_LACLA.Residues 76-122 are 45% similar to a (PROTEOME COMPLETE PSEUDOURIDINE SYNTHASE) protein domain (PD380172) which is seen in Q9CIJ3_LACLA.Residues 63-193 are 27% similar to a (PROTEOME COMPLETE YABO/YCEC/SFHB NMA1085) protein domain (PD353037) which is seen in Q9JUY2_NEIMA.Residues 72-253 are 24% similar to a (PROTEINS COLI OF) protein domain (PD112927) which is seen in Q06244_YEAST.Residues 78-274 are 25% similar to a (L2759.7) protein domain (PD112947) which is seen in Q25346_LEIMA.Residues 77-170 are 36% similar to a (COMPLETE PROTEOME SYNTHASE PSEUDOURIDINE) protein domain (PD414934) which is seen in Q9K1F6_NEIMB.Residues 199-248 are 56% similar to a (SYNTHASE COMPLETE PROTEOME PSEUDOURIDINE RIBOSOMAL LARGE) protein domain (PD224882) which is seen in YBC5_CHLVI.Residues 78-170 are 32% similar to a (PROTEOME COMPLETE SYNTHASE) protein domain (PD398242) which is seen in Q9PAB2_XYLFA.Residues 124-185 are 56% similar to a (SYNTHASE PSEUDOURIDINE PROTEOME COMPLETE) protein domain (PD409890) which is seen in Q9CIJ3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 15:39:06 2006","Tue Sep 12 15:36:41 2006","Tue Sep 12 15:36:41 2006","Fri Jan 11 10:22:18 2002","Fri Jan 11 10:22:18 2002","Fri Jan 11 10:22:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0953 is paralogously related (blast p-value < 1e-3) to SMu0778, SMu1772, SMu1559 and SMu0580, all predicted 16S pseudouridylate synthases.","Tue Jan 29 10:23:53 2002","","No significant hits to the NCBI PDB database.","SMU.1044c","","Residues 84 to 236 (E-value = 3e-49) place SMu0953 in the PseudoU_synth_2 family which is described as RNA pseudouridylate synthase (PF00849)","Fri Jan 11 10:22:18 2002","24379482","","","Del Campo M, Kaya Y, Ofengand J.Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli.RNA. 2001 Nov;7(11):1603-15.PMID: 11720289Gutgsell NS, Del Campo MD, Raychaudhuri S, Ofengand J.A second function for pseudouridine synthases: A point mutant of RluD unable to form pseudouridines 1911, 1915, and 1917 in Escherichia coli 23S ribosomal RNA restores normal growth to an RluD-minus strain.RNA. 2001 Jul;7(7):990-8.PMID: 11453071 ","","Fri Jan 11 10:32:26 2002","1","","","SMU.1044c","367" "SMu0954","994506","993673","834","ATGACACAGATGAACTTTACCGATAAAATTAAAGTTGCTATTATAGCAAATGGAAAATATCAAAGTAAACGCCTAACAGCAAAACTTTTTGCAATATTAAGAAATGATGATAGATTTTATCTAACCAAAAAAAATCCTGATATTGTTATTACGATTGGTGGTGATGGTATGCTCTTGTCTGCCTTTCATATGTATGAAAAGTGCTTGGATCATGTTAGATTTGTTGGTATTCATACAGGACATTTAGGTTTTTATACTGATTATCGTGATTTTGAAGTCGATAAGTTATTAGAGAATTTACATTCTGATAAAGGCGAAAAGGCATCTTATCCTATCTTAAAAGTGACTGCTACGCTAGCTGATGGTCGTCAGTTAACATCCAGAGCTCTTAACGAAGCTACTATTAGAAGAATTGAAAAAACCATGGTAGCAGATGTCGTTATCAATAAGGTTCATTTTGAGCGTTTTCGAGGAGACGGCATTTCTGTTTCCACTCCAACTGGAAGCACCGCTTATAACAAATCATTAGGGGGGGCTGTTTTGCACCCGACCATTGAAGCCTTACAGTTAACAGAAATTTCAAGTCTTAACAATCGTGTCTTTAGAACATTAGGAAGCTCCATTATTGTTCCTAAAAAAGACAAAATTGAAATCGTTCCTAAACGCTTAGGGTCTTATGTTCTATCTATTGATAATAAAACTTATACGCATCGAAATGTTGCTAAAATTGAATATGAAATTGATCGTAAAAAAATTAGCTTTGTATCAACACCAAGCCACACTAGTTTTTGGGAACGCGTCAAGGATGCTTTTATCGGAGATTTCGATTCATGA","10.20","11.12","31309","MTQMNFTDKIKVAIIANGKYQSKRLTAKLFAILRNDDRFYLTKKNPDIVITIGGDGMLLSAFHMYEKCLDHVRFVGIHTGHLGFYTDYRDFEVDKLLENLHSDKGEKASYPILKVTATLADGRQLTSRALNEATIRRIEKTMVADVVINKVHFERFRGDGISVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVFRTLGSSIIVPKKDKIEIVPKRLGSYVLSIDNKTYTHRNVAKIEYEIDRKKISFVSTPSHTSFWERVKDAFIGDFDS","993687","","NAD(+) kinase (ATP-NAD kinase)","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins :residues 1-277 are 80% similar to S.pyogenes gi15675106 . Residues 3-276 are 66% similar to S.pneumoniae gi15903049.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1094 (1e-125).","

InterPro
IPR002504
Family

ATP-NAD/AcoX kinase
PF01513	$\"[11-257]T$	NAD_kinase

InterPro
IPR014425
Family

ATP-NAD(H) kinase
PIRSF004914	$\"[46-277]T$	ATP-NAD_NADH_kin

noIPR
unintegrated

unintegrated
G3DSA:2.60.200.30	$\"[118-248]T$	G3DSA:2.60.200.30
G3DSA:3.40.50.10330	$\"[10-115]T$	G3DSA:3.40.50.10330
PIRSF500155	$\"[10-277]T$	NAD_NADH_kin_pro
PTHR20275	$\"[32-271]T$	PTHR20275
SSF111331	$\"[11-271]T$	SSF111331

","BeTs to 16 clades of COG0061COG name: Predicted kinaseFunctional Class: RThe phylogenetic pattern of COG0061 is amtkYqvCeBrhujgpol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB002504 (Domain of unknown function DUF15) with a combined E-value of 4.4e-42. IPB002504A 47-59 IPB002504B 72-89 IPB002504C 129-135 IPB002504D 146-195","Residues 10-144 are 41% similar to a (KINASE NAD INORGANIC NADP) protein domain (PD120254) which is seen in PPNK_BACSU.Residues 195-272 are 46% similar to a (KINASE NAD INORGANIC NADP) protein domain (PD212073) which is seen in PPNK_LACLA.Residues 11-90 are 55% similar to a (KINASE NAD NADP TRANSFERASE) protein domain (PD120247) which is seen in PPNK_LACLA.Residues 145-194 are 68% similar to a (KINASE NAD TRANSFERASE NADP) protein domain (PD002781) which is seen in PPNK_LACLA.Residues 140-193 are 44% similar to a (KINASE NAD NADP POLYP/ATP) protein domain (PD311807) which is seen in PPNK_METJA.Residues 195-273 are 36% similar to a (KINASE NAD NADP TRANSFERASE) protein domain (PD120260) which is seen in PPNK_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 10:57:45 2002","Tue Sep 12 15:48:32 2006","Tue Sep 12 15:48:32 2006","Fri Jan 11 10:57:33 2002","Fri Jan 11 10:57:33 2002","Fri Jan 11 10:57:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0954 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 10:57:45 2002","","No significant hits to the NCBI PDB database.","SMU.1045c","","Residues 11 to 258 (E-value = 2.4e-43) place SMu0954 in the NAD_kinase family which is described as ATP-NAD kinase (PF01513)","Fri Jan 11 10:57:33 2002","24379483","","","","","","1","","","SMU.1045c","368" "SMu0955","995146","994481","666","ATGAATTGGGAAGAATTTCTGGACCCTTATATTCAGGCAGTAGGTGAATTAAAAATTAAGTTCAGAGGAATTCGTAAGCAATTTCGTAAGCAAAAACGCCATTCACCAATTGAATTTGTGACAGGACGTGTTAAACCAATCGAAAGTATCAAAGAAAAAATGGTTTTACGAGGAATTAAAAAGGAAAACCTCACTCAAGATATGCAGGATATTGCGGGATTAAGAATTATGGTTCAGTTTGTTGATGATGTCAACGATGTTTTAGAGCTTTTACGTCAACGCAAAGACATGAAAGTGATACAAGAACGTGATTATATCAATAATTTAAAACCCAGCGGTTATCGCTCTTATCACGTTATTGTTGAATATCCTGTTGATACTATCAGTGGACAAAGAATTATTATGGCTGAAATCCAAATTCGAACTCTGGCTATGAATTTTTGGGCAACAATTGAACACTCTCTCAATTACAAATACCATGGTGAATTTCCTGAAGATATTAAAAGACGTTTAGAATTAACCTCCAAAATTGCTTTTCAATTAGACGAGGAAATGCGGCAGATTCGCGATGACATTAAGGAAGCACAACTATTATTTGATGCTGAGACTAGAAAGCTAAACGATGGTGTAGGAAATAGTGATGACACAGATGAACTTTACCGATAA","7.00","0.00","26268","MNWEEFLDPYIQAVGELKIKFRGIRKQFRKQKRHSPIEFVTGRVKPIESIKEKMVLRGIKKENLTQDMQDIAGLRIMVQFVDDVNDVLELLRQRKDMKVIQERDYINNLKPSGYRSYHVIVEYPVDTISGQRIIMAEIQIRTLAMNFWATIEHSLNYKYHGEFPEDIKRRLELTSKIAFQLDEEMRQIRDDIKEAQLLFDAETRKLNDGVGNSDDTDELYR","994495","","GTP pyrophosphokinase","Cytoplasm","Matches in gapped BLAST to GTP pyrophosphokinase and to some conserved hypothetical proteins: residues 1-221 are78% similar to the enzyme in S.pyogenes (gi15675105). Residues 1-221 are 75% similar to the conserved hypothetical protein from S.pneumoniae (gi15900965).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1095 (1e-102).","

InterPro
IPR007685
Domain

RelA/SpoT
PF04607	$\"[42-161]T$	RelA_SpoT

noIPR
unintegrated

unintegrated
PTHR21262	$\"[1-192]T$	PTHR21262
SSF81301	$\"[4-188]T$	SSF81301

","BeTs to 7 clades of COG0317COG name: Guanosine polyphosphate pyrophosphohydrolases/synthetasesFunctional Class: T,KThe phylogenetic pattern of COG0317 is -----qvcEbrHujgpo----Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 10-192 are 71% similar to a (SYNTHETASE PROTEOME COMPLETE KINASE) protein domain (PD002902) which is seen in Q9CIJ5_LACLA.Residues 32-194 are 22% similar to a (PXO1-131 PLASMID) protein domain (PD320802) which is seen in Q9X388_BACAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 11:02:38 2002","Fri Jan 11 11:02:38 2002","Wed Aug 30 14:29:41 2006","Fri Jan 11 11:00:33 2002","","Fri Jan 11 11:00:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0955 is paralogously related (blast p-value < 1e-3) to SMu0840, a predicted conserved hypothetical protein and SMu1856, a predicted GTP pyrophosphokinase (stringent response-like protein) (PPGPP synthetase I). ","Tue Jan 29 10:26:06 2002","","No significant hits to the NCBI PDB database.","SMU.1046c","","Residues 42 to 163 (E-value = 6.6e-50) place SMu0955 in the RelA_SpoT family which is described as Region found in RelA / SpoT proteins (PF04607)","Fri Jan 11 11:00:33 2002","24379484","","","Svitil AL, Cashel M, Zyskind JW.Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli.J Biol Chem. 1993 Feb 5;268(4):2307-11.PMID: 8428905 ","","Fri Jan 11 11:04:32 2002","1","","","SMU.1046c","565" "SMu0956","995653","995546","108","ATGGTTCATCTTTTTTCCTTTGTTAAGCTTATTTATTATGATATAATGAAGTATTCAATTGAAGAAAAAGTCTTTTTTGAGTCGCCCGTAGGTGAAATTATCCAGTGA","4.80","-1.78","4226","MVHLFSFVKLIYYDIMKYSIEEKVFFESPVGEIIQ","995560","","hypothetical protein","Extracellular, Cytoplasm","No significant hits in gapped BLAST found.SMu0956 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 11:07:04 2002","Fri Jan 11 11:07:04 2002","Fri Jan 11 11:07:04 2002","Fri Jan 11 11:07:04 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu0956 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 11:07:04 2002","","No significant hits to the NCBI PDB database.","SMU.1047c","","No significant hits to the Pfam 11.0 database","Fri Jan 11 11:07:04 2002","24379485","","","","","","1","","","SMU.1047c","" "SMu0957","995645","996211","567","ATGAACCATATTGAAATTGAATACAAAACACTTTTGACTAAAGAAGAATTTAATCGTATCAAAGACTATCTGCAGCAGGTTGAACCAATTGTACAAACCAACTATTACTTTGATACAATTAATTTTGAGTTAAAGACCCATAAAATGTCTCTGCGCATCAGAACTTTTACTCATAGTGCAGAGTTAACTTTAAAGGTTCCAAAAAAGATTGGAAATTTAGAATACAATCATCAGTTAAGTCTGACAGAGGCTCAAGAGATTATAAAAAGCAAACAATTACCCAATATTGAGATAAAGCAATTCCTTATCCGAGCAGGAATTAACTTAAGCAAGTTAACAGTCTTGGGAAATCTGACAACAACACGTCGTGAAATTAATACGAAAATCGGACTTATGGCTCTTGACTATAATTGCTACGCAGGACGGCAAGATTATGAACTTGAATTAGAGGTTGCTGATGCTCAAAAAGGTAAGGCTGATTTTGAAGCTTTTTTAAAGGCGAACCATATTAAATTTAAATATGCTAGAAGTAAGGTAGCACGTTTTTCTGCTACTTTAACTGAATAA","9.90","6.16","21907","MNHIEIEYKTLLTKEEFNRIKDYLQQVEPIVQTNYYFDTINFELKTHKMSLRIRTFTHSAELTLKVPKKIGNLEYNHQLSLTEAQEIIKSKQLPNIEIKQFLIRAGINLSKLTVLGNLTTTRREINTKIGLMALDYNCYAGRQDYELELEVADAQKGKADFEAFLKANHIKFKYARSKVARFSATLTE","996219","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 1-186 are 58% similar to S.pyogenes (gi|15675104|) and residues 1-182 are 50% similar to S.pneumoniae (gi|15900964|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1096 (1e-62).","

InterPro
IPR008172
Domain

Adenylate cyclase
PF01928	$\"[3-188]T$	CYTH

InterPro
IPR009195
Family

Uncharacterised CYTH protein
PIRSF012526	$\"[1-188]T$	CYTH_UCP012526

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-182 are 47% similar to a (PROTEOME COMPLETE YJBK YDGF) protein domain (PD104930) which is seen in Q9CIJ7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 11:09:40 2002","Fri Jan 11 11:09:40 2002","Fri Jan 11 11:09:40 2002","Fri Jan 11 11:09:40 2002","","Fri Jan 11 11:09:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0957 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 11:09:40 2002","","No significant hits to the NCBI PDB database.","SMU.1048","","Residues 3 to 188 (E-value = 2.2e-33) place SMu0957 in the CYTH family which is described as CYTH domain (PF01928)","Fri Jan 11 11:09:40 2002","24379486","","","","","","1","","","SMU.1048","809" "SMu0958","996314","997294","981","ATGTCTAACGCTTATCCTGACAAACACTTAAAACTTTTTTCTTTGACTTCTAATACAGCCATTGCTGAAAAAATTGCAAAAGTTGTTGGTGTACCATTAGGAAAATTATCTTCTCGTCAATTCTCTGACGGTGAAATTATGATTAACATTGAAGAAAGTGTTCGCGGTAACGATATCTATGTCATCCAATCAACCAGTTATCCGGTTAATAATCACCTTTGGGAACTTTTAATTATGGTTGATGCTTGCAAACGCGCAAGTGCTAACAGTGTTAATGTTGTCATTCCTTATTTTGGCTATTCGCGTCAAGATCGCATCGCTGCTGCTCGTGAACCTATTACGGCAAAATTAGTTGCTAATATGCTGGTTAAAGCAGGTGTTGACCGTGTGCTAACCTTAGATTTACATGCTGTACAGGTGCAAGGTTTCTTTGATATTCCTGTTGACAATTTATTTACTACACCGCTATTTGCTGATCACTATACCAATCTTGGTTTGTATGGCGAAGATATTGTAGTTGTCAGCCCTAAAAATTCTGGTATTAAACGTGCTCGCAGTCTAGCACAATACCTTGATGCACCTATTGCTATTATTGACTATGCTCAGGATGATGATTCTTCACGTGAAGAAGGTTATATTATCGGTGAGGTAGCAGGCAAAAAAGCTATTTTAATTGATGATATTCTTAATACAGGAAAAACGTTTGCAGAGTCCGCCAAAATTGTTGAACGCGGGGGCGCTACTGAAATTTACGCTGTTGCTAGTCATGGATTGTTTGCCAGCGGTGCCACTGAAATTTTGCAAGCAGCTCCTATTAAAGATATCTTGATTACAGATTCTGTTTACACGGAACAAGAATTACCTAGCAATTTACATTATTTGTCTGCTAGCGAGTTAATTGGAGAGGCAATCATTCGCATTCATGAAAGACGACCGGTAAGTCCATTGTTTGCTTATAATCGTAAAGGAGATGAAGCTTAA","5.20","-8.34","35657","MSNAYPDKHLKLFSLTSNTAIAEKIAKVVGVPLGKLSSRQFSDGEIMINIEESVRGNDIYVIQSTSYPVNNHLWELLIMVDACKRASANSVNVVIPYFGYSRQDRIAAAREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTTPLFADHYTNLGLYGEDIVVVSPKNSGIKRARSLAQYLDAPIAIIDYAQDDDSSREEGYIIGEVAGKKAILIDDILNTGKTFAESAKIVERGGATEIYAVASHGLFASGATEILQAAPIKDILITDSVYTEQELPSNLHYLSASELIGEAIIRIHERRPVSPLFAYNRKGDEA","997302","For other 'prs' genes see SMu0019 (prs).","phosphoribosyl pyrophosphate synthetase","Cytoplasm","Several matches in gapped BLAST to phosphoribosyl pyrophosphate synthetase:residues 1-323 are 77% similar to the enzyme in S.pyogenes (gi|15675103|). Residues 8-322 are 77% similar to the protein from S.pneumoniae (gi|15673839|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1097 (1e-149).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[145-266]T$	Pribosyltran

InterPro
IPR000842
Family

Phosphoribosyl pyrophosphate synthetase
PS00114	$\"[134-149]N$	PRPP_SYNTHETASE

InterPro
IPR005946
Family

Ribose-phosphate pyrophosphokinase
TIGR01251	$\"[10-318]T$	ribP_PPkin

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2020	$\"[1-176]T$	G3DSA:3.40.50.2020
PTHR10210	$\"[10-318]T$	PTHR10210
PTHR10210:SF14	$\"[10-318]T$	PTHR10210:SF14

","BeTs to 15 clades of COG0462COG name: Phosphoribosylpyrophosphate synthetaseFunctional Class: F,EThe phylogenetic pattern of COG0462 is AmtkYqvcebrhujgpol---Number of proteins in this genome belonging to this COG is 2","***** IPB000842 (Phosphoribosyl pyrophosphate synthetase) with a combined E-value of 1.3e-91. IPB000842A 40-82 IPB000842B 110-155 IPB000842C 170-197 IPB000842D 198-252 IPB000842E 255-282 IPB000842F 294-317","Residues 24-220 are 29% similar to a (PROTEOME PHOSPHORIBOSYL TRANSFERASE) protein domain (PD102473) which is seen in O51494_BORBU.Residues 10-190 are 76% similar to a (TRANSFERASE PYROPHOSPHOKINASE RIBOSE-PHOSPHATE) protein domain (PD001439) which is seen in Q9CEI4_LACLA.Residues 9-222 are 40% similar to a (TRANSFERASE PHOSPHORIBOSYLPYROPHOSPHATE) protein domain (PD035825) which is seen in Q9VT33_DROME.Residues 8-144 are 26% similar to a (TRANSFERASE PHOSPHORIBOSYL SYNTHASE) protein domain (PD306086) which is seen in Q9XGA0_SPIOL.Residues 223-281 are 35% similar to a (TRANSFERASE SYNTHETASE PHOSPHORIBOSYL PYROPHOSPHOKINASE) protein domain (PD016748) which is seen in Q23166_CAEEL.Residues 223-304 are 28% similar to a (PROTEOME COMPLETE PYROPHOSPHOKINASE) protein domain (PD413639) which is seen in O29666_ARCFU.Residues 221-281 are 67% similar to a (PYROPHOSPHOKINASE RIBOSE-PHOSPHATE) protein domain (PD375317) which is seen in Q9CEI4_LACLA.Residues 283-324 are 52% similar to a (PROTEOME COMPLETE KINASE RIBOSE-PHOSPHATE) protein domain (PD375768) which is seen in Q9CEI4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 25 13:23:51 2002","Wed Apr 24 16:22:52 2002","Tue Oct 15 10:59:14 2002","Fri Jan 11 13:36:46 2002","Fri Jan 11 13:36:46 2002","Fri Jan 11 13:36:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0958 is paralogously related (blast p-value < 1e-3) to SMu0019, a predicted phosphoribosyl pyrophosphate synthetase (PRPP synthetase) and SMu1116, a predicted orotate phosphoribosyltransferase.","Tue Jan 29 10:28:49 2002","Fri Jan 11 13:36:46 2002","pdb|1DKR|B Chain B, Crystal Structures Of Bacillus Subtilis Pho... 321 7e-089","SMU.1050","","Residues 145 to 266 (E-value = 8.4e-16) place SMu0958 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Fri Jan 11 13:36:46 2002","24379487","","","Drouault S, Anba J, Bonneau S, Bolotin A, Ehrlich SD, Renault P. The peptidyl-prolyl isomerase motif is lacking in PmpA, the PrsA-like protein involved in the secretion machinery of Lactococcus lactis.Appl Environ Microbiol. 2002 Aug;68(8):3932-42.PMID: 12147493 Nilsson,D., Hove-Jensen,B. and Arnvig,K.Primary structure of the tms and prs genes of Bacillus subtilisMol. Gen. Genet. 218 (3), 565-571 (1989)PubMed: 2555671Eriksen,T.A., Kadziola,A., Bentsen,A.K., Harlow,K.W. and Larsen,S.Structural basis for the function of Bacillus subtilisphosphoribosyl-pyrophosphate synthetaseNat. Struct. Biol. 7 (4), 303-308 (2000)PubMed: 10742175","","Fri Oct 25 13:23:51 2002","1","","","SMU.1050","369" "SMu0959","997355","998416","1062","ATGACAGACACGATGACTTCTGTTTTTGGCAATCCTTCTAGTATTCATACTTATGGTAGAACGGCTAATAAGGTCTTAAGAGAGCGTCGTCAACAAGTTGCTCAGATTTTTGATGTAAAATCGCGAAATATTATTTTTACTTCTGGTGGAACTGAGAGCAATAATACTGCCATTAAAGGTTATGCTCTAGCAAATCAGTTCAAAGGTAAACACATTATCTCAACTAGCATTGAACATCATTCTGTTTTGCATACTCTTGATTACTTAGAACAACGTTTTGGTTTTGAAGTGACTTACCTTAATCCTATCAAAGGTAAAATTCTTATGCAACAAGTTAAAGACGCTTTGCGATCTGATACGATTTTAGTATCTATAATGTTTGCTAATAATGAAACAGGAGATATATTGCCAATTCAAGAAATCGGCAATGTGATTAAAGAACATCAGGCAGTTTTTCACGTTGATGCTGTTCAAACAGTTGGCAAACTGCCTATTCACCCTAAAGAACTAAACATTGATTTTCTTTCCGCTTCTGCTCATAAATTTCATGGTCCAAAAGGGGTAGGGATTCTGTATGTTGCTGATAATCTTCATTTTGATAATCTGCTTCATGGGGGTGAGCAAGAAGAAAAACGGCGTGCCAGTACAGAAAATCTCATCGGAATTGTTGGTCTTACTCAAGCTTTAAAGGATAGTTATCTTCATCAGGAAAATGTTTTAAACTATATTGACGGACTCAAAAAGTTATTCCTAGATGAATTGGAAGGTTTAGATTACTATCTTAATTCTAATGAAGATGCTCTTCCTCATGTTATTAATATTGGTTTCCCTAATTATAATAATAGTATTTTACTGACACAATTAGATCTAGCAGGATTTGCAATTTCAACTGGTTCCGCTTGTACGGCTGGTACTGTTGATCCCAGTCATGTCTTGATAGCAAAATATGGATTAGATTCTGTACGGCTTCAAGAGTCAATACGTATCAGTTTTTCAGACTTGAATACTCCAGATGAGGTTAAGGCATTAGCAGTAAAAATTAAAGAAATTATAGGAAAATAA","6.60","-3.42","39093","MTDTMTSVFGNPSSIHTYGRTANKVLRERRQQVAQIFDVKSRNIIFTSGGTESNNTAIKGYALANQFKGKHIISTSIEHHSVLHTLDYLEQRFGFEVTYLNPIKGKILMQQVKDALRSDTILVSIMFANNETGDILPIQEIGNVIKEHQAVFHVDAVQTVGKLPIHPKELNIDFLSASAHKFHGPKGVGILYVADNLHFDNLLHGGEQEEKRRASTENLIGIVGLTQALKDSYLHQENVLNYIDGLKKLFLDELEGLDYYLNSNEDALPHVINIGFPNYNNSILLTQLDLAGFAISTGSACTAGTVDPSHVLIAKYGLDSVRLQESIRISFSDLNTPDEVKALAVKIKEIIGK","998424","For other 'nif' genes see SMu0226 (nifS) and SMu0227 (nifU).","aminotransferase (class V); possible iron-sulfur cofactor synthesis protein;pyridoxal-phosphate dependent aminotransferase","Cytoplasm","Several matches in gapped BLAST to iron-sulfur cofactor synthesis protein and to pyridoxal-phosphate dependent aminotransferase: residues 1-352 are 64% similar to the protein in S.pyogenes (gi15675102) and are 59% similar to pyridoxal-phosphate dependent aminotransferase from S.pneumoniae (gi15903045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1098 (1e-136).","

InterPro
IPR000192
Family

Aminotransferase, class V
PF00266	$\"[9-343]T$	Aminotran_5
PS00595	$\"[172-191]T$	AA_TRANSFER_CLASS_5

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[1-230]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[1-353]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PIRSF005572	$\"[1-353]T$	NifS
PTHR11601	$\"[1-351]T$	PTHR11601

","BeTs to 13 clades of COG1104COG name: Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes (NifS family)Functional Class: EThe phylogenetic pattern of COG1104 is A--kYQvCeBRHuj---lINXNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 28-194 are 54% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in O34599_BACSU.Residues 19-85 are 47% similar to a (AMINOTRANSFERASE PROTEOME PYRIDOXAL LYASE) protein domain (PD311278) which is seen in ISCS_PSEAE.Residues 267-320 are 70% similar to a (LYASE PYRIDOXAL DESULFURASE PHOSPHATE 4.4.1.- CYSTEINE) protein domain (PD189309) which is seen in Q9CEI2_LACLA.Residues 94-187 are 41% similar to a (AMINOTRANSFERASE V PROTEOME COMPLETE) protein domain (PD393971) which is seen in Q9RXU1_DEIRA.Residues 189-228 are 60% similar to a (LYASE PHOSPHATE 4.4.1.- PYRIDOXAL) protein domain (PD001054) which is seen in ISCS_METTE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 16:58:10 2006","Tue Sep 12 16:58:10 2006","Tue Sep 12 16:58:10 2006","Fri Jan 11 14:14:53 2002","","Fri Jan 11 14:14:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0959 is paralogously related (blast p-value < 1e-3) to SMu0765, a predicted aminotransferase and SMu0226, a predicted NifS protein homolog, class-V aminotransferase.","Tue Jan 29 10:33:54 2002","Tue Sep 12 16:58:10 2006","pdb1ECXB Chain B, Nifs-Like Protein >gi7546479pdb1ECXA Ch... 228 1e-060pdb1EG5B Chain B, Nifs-Like Protein >gi7546280pdb1EG5A Ch... 221 1e-058pdb1C0NA Chain A, Csdb Protein, Nifs Homologue 95 1e-020","SMU.1051","","Residues 1 to 343 (E-value = 1.7e-81) place SMu0959 in the Aminotran_5 family which is described as Aminotransferase class-V (PF00266)","Fri Jan 11 14:14:53 2002","24379488","","","Flint,D.H.Escherichia coli contains a protein that is homologous in functionand N-terminal sequence to the protein encoded by the nifS gene ofAzotobacter vinelandii and that can participate in the synthesis of the Fe-S cluster of dihydroxy-acid dehydrataseJ. Biol. Chem. 271 (27), 16068-16074 (1996)PubMed: 8663056Kambampati,R. and Lauhon,C.T.IscS is a sulfurtransferase for the in vitro biosynthesis of4-thiouridine in Escherichia coli tRNABiochemistry 38 (50), 16561-16568 (1999)PubMed: 10600118Mihara,H., Kurihara,T., Yoshimura,T. and Esaki,N.Kinetic and mutational studies of three NifS homologs fromEscherichia coli: mechanistic difference between L-cysteinedesulfurase and L-selenocysteine lyase reactionsJ. Biochem. 127 (4), 559-567 (2000)PubMed: 10739946","","Fri Jan 11 14:39:58 2002","1","","","SMU.1051","370" "SMu0960","998418","998765","348","ATGGCTTTTGAAAAAACAATACAATTACCTGATTGTAAGTACAGTTATACAATCAGCTCTAAAGTAAAAAAATTTACCCTACAAGATACGACTTTTATGCAAAACAAATTAGGTAATTACGAATTAAATCGCCTATTAGAAAAGGTTCCTAATAGTGGGGAGGGTTTCCCATTAAAAATCACCATTAATAAAGACTTAACAGCCTTTAAACTGACCATTACAGATAAATCTGGACTTAGAGTTGTCAATATTTTCAAATCAGAAGAGAATCACATTATTCAGGATAAATTTTATTTTTTAATGGACAGTTTAGTTGAACGTGATATTTTTGAAAAGAAAGTTAGATAA","9.90","4.18","13462","MAFEKTIQLPDCKYSYTISSKVKKFTLQDTTFMQNKLGNYELNRLLEKVPNSGEGFPLKITINKDLTAFKLTITDKSGLRVVNIFKSEENHIIQDKFYFLMDSLVERDIFEKKVR","998773","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins:residues1-114 are 73% similar to the protein in S.pyogenes (gi|15675101|).Residues 1-115 are 70% similar to the protein in S.pneumoniae (gi|15900961|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1099 (4e-48).","

InterPro
IPR014965
Family

Domain of unknown function DUF1831
PF08866	$\"[1-113]T$	DUF1831

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-112 are 58% similar to a (PROTEOME COMPLETE) protein domain (PD395639) which is seen in Q9CEI1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 29 12:52:43 2002","Tue Jan 29 12:52:43 2002","Tue Jan 29 12:52:43 2002","Tue Jan 29 12:52:43 2002","","Tue Jan 29 12:52:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0960 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 12:52:43 2002","","No significant hits to the NCBI PDB database.","SMU.1052","","No significant hits to the Pfam 11.0 database","Tue Jan 29 12:52:43 2002","24379489","","","","","","1","","","SMU.1052","810" "SMu0961","999061","999702","642","GTGACTTTCGATAAAACTATCCCTAAGGCGACAATCAAGCGTTTATCACTTTATTACCGTATTTTTAAACGCTTCCATTCAGAAAATATAGAAAAGGCAAGTTCTAAGCAAATAGCGGAAGCCATTGGTATCGATTCAGCGACAGTTAGACGTGATTTTTCTTATTTTGGCGAGTTAGGCCGTCGTGGTTTTGGTTATGATGTTAAAAAACTAATGAACTTTTTTGCTGATATTCTCAATGATACATCAACTACGAATGTCCTTCTTGTGGGAGTTGGCAATATTGGTCGTGCTCTCCTGAATTATCGTTTTCATGAACGTAATAAAATGAAAATTGCTATGGCATTTGATACAGATGATAATGAACAGGTCGGTCAAACGACAAGTGACGGTATTCCTATTTACGGCATTTCTAGTATAAAAGAAAAATTGATTGGTACAGACGTTCAAACAGCTATTTTAACAGTTCCTAGCAGTAAAGCTCAAGAAGTCGCCAATATACTTATTGATGCTGGGATCAAAGGAATCTTGTGTTTTTCACCTGTTCATCTTTCCTTGCCAAAGGGAGTTGTTGCTCAATATGTCGATTTAACTAGCGAATTACAAACTCTATTGTATTTTATGAATCAAGAACAATTCTAA","9.10","2.67","23787","MTFDKTIPKATIKRLSLYYRIFKRFHSENIEKASSKQIAEAIGIDSATVRRDFSYFGELGRRGFGYDVKKLMNFFADILNDTSTTNVLLVGVGNIGRALLNYRFHERNKMKIAMAFDTDDNEQVGQTTSDGIPIYGISSIKEKLIGTDVQTAILTVPSSKAQEVANILIDAGIKGILCFSPVHLSLPKGVVAQYVDLTSELQTLLYFMNQEQF","999710","","possible redox-sensing transcriptional repressor Rex","Cytoplasm, Membrane","Limited matches in gapped BLAST to conserved hypothetical proteins : residues 7-211 are 80% similar to the protein in S.pneumoniae(gi15903042).Residues 1-210 are 77% similar to the protein in S.pyogenes (gi15675100).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1100 (1e-95).","

InterPro
IPR003781
Domain

CoA-binding
PF02629	$\"[80-186]T$	CoA_binding

InterPro
IPR009718
Domain

Rex DNA-binding, C-terminal
PF06971	$\"[5-54]T$	Put_DNA-bind_N

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[5-77]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[78-210]T$	no description

","BeTs to 4 clades of COG0074COG name: Succinyl-CoA synthetase, alpha subunitFunctional Class: CThe phylogenetic pattern of COG0074 is Amt-yQ-cEbrh------inxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 5-174 are 52% similar to a (PROTEOME COMPLETE DNA-BINDING YDIH) protein domain (PD112016) which is seen in Q9CGN6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 29 13:05:43 2002","Wed Aug 30 14:57:10 2006","Wed Aug 30 14:57:10 2006","Tue Jan 29 13:05:15 2002","","Tue Jan 29 13:05:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0961 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 13:05:43 2002","","No significant hits to the NCBI PDB database.","SMU.1053","","Residues 177 to 208 (E-value = 5.8e-16) place SMu0961 in the Put_DNA-bind_C family which is described as Putative DNA-binding protein C-terminus (PF06971)","Tue Jan 29 13:05:15 2002","24379490","","","","","","1","","","SMU.1053","566" "SMu0962","999726","1000421","696","ATGAATAAACCTATTATTGGTATTTCGGGTAATGAAAGGCCACATGCTAAATTTCCCGATATCACTTGGTCTTATACACCATCTGGTTATGTCAAGGGGGTTCAGGAAGCTGGCGGTCTACCGCTAGTTATCCCTATCAGTGATCCCAGTTTTGCCGAATATTATGTTTCAATGATTGATAAACTTATCTTAACCGGCGGTCAAAATGTTGACCCTGTTTTTTATGGTGAAGACAAAGATACAAGTGATAACGATTTTTATTTGGCGCGTGATTTATTTGAGTTTGCTCTCGTTGAAGAAACGATTAAGCAAGAAAAACCTATTTTTTCTGTTTGCCGCGGAACTCAATTAATGAATATTGCATTGGGTGGCTCACTTAATCAAGATATTGAACACCATTGGCAAGATGCTCCTACTGACTATCTCAGCCAAAATATGCTAATTAAGCCTGATACCGCTCTAGAAAAAATTTACGGCACCTCTACTTCGATTAATTCCTTCCATCATCAGAGCATTAAACGTCTTGCGGATGATTTGGAAATTATTGCTTATGATCCTACTGATGATACTATTGAAGCGGTGACGTCTCGTAATTCTGATATCACTTTTCTAGGTGTTCAATGGCACCCTGAACTGCTGCTTGAATCACGAAAAGAGGATCGAGAACTTTTCAATTATGTTGTTAGAGAACTTTAA","4.40","-16.59","26134","MNKPIIGISGNERPHAKFPDITWSYTPSGYVKGVQEAGGLPLVIPISDPSFAEYYVSMIDKLILTGGQNVDPVFYGEDKDTSDNDFYLARDLFEFALVEETIKQEKPIFSVCRGTQLMNIALGGSLNQDIEHHWQDAPTDYLSQNMLIKPDTALEKIYGTSTSINSFHHQSIKRLADDLEIIAYDPTDDTIEAVTSRNSDITFLGVQWHPELLLESRKEDRELFNYVVREL","1000429","For other 'gua' genes see SMu0974 (guaA) and SMu1957 (guaB). ","glutamine amidotransferase","Cytoplasm","Several matches in gapped BLAST to glutamine amidotransferase, class I and conserved hypothetical protein:residues 1-231 are 59% similar to the enzyme in S.pneumoniae (gi15674251). Residues 1-230 are 56% similar conserved hypothetical protein from S.pyogenes (gi15675099).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1643 (6e-58).","

InterPro
IPR011697
Domain

Peptidase C26
PF07722	$\"[4-211]T$	Peptidase_C26

InterPro
IPR011702
Domain

Glutamine amidotransferase superfamily
PR00096	$\"[107-118]T$ $\"[205-218]T$	GATASE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.880	$\"[1-211]T$	G3DSA:3.40.50.880
PTHR11922	$\"[99-211]T$	PTHR11922
PTHR11922:SF2	$\"[99-211]T$	PTHR11922:SF2
SSF52317	$\"[1-230]T$	SSF52317

","BeTs to 3 clades of COG2071COG name: Predicted glutamine amidotransferasesFunctional Class: RThe phylogenetic pattern of COG2071 is --------e-r---------XNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 3-130 are 27% similar to a (PROTEOME COMPLETE) protein domain (PD203637) which is seen in Q9ZDC7_RICPR.Residues 35-126 are 38% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE SMALL CHAIN) protein domain (PD105693) which is seen in YDP3_LACLC.Residues 44-211 are 27% similar to a (PROTEOME CJ1417C COMPLETE) protein domain (PD274638) which is seen in Q9PMP0_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 17 14:46:27 2006","Tue Jan 29 13:10:03 2002","Mon Jul 17 14:46:27 2006","Tue Jan 29 13:10:03 2002","","Tue Jan 29 13:10:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0962 is paralogously related (blast p-value < 1e-3) to SMu0484, a predicted anthranilate synthase component II.","Tue Jan 29 14:59:34 2002","","No significant hits to the NCBI PDB database.","SMU.1054","","No significant hits to the Pfam 11.0 database","Tue Jan 29 13:10:03 2002","24379491","","","","","","1","","","SMU.1054","847" "SMu0963","1001047","1000418","630","ATGACTTATGGTCCTGAAAGTTTGAGTAATCAAGAATTATTGGCTATATTATTGCGAACTGGTACTAAAAAGGAACATGTTCTCAATCTCTCAATAAAAATTTTAAATGGTCTAGATAGCTTGGCCGATTTTCGCAGCTTATCCTTAGAAGAACTGCAGGAAATTGAAGGAATCGGTCAAGTACGATCAGTAGAAATTAAAGCTATGCTGGAATTATCCAAAAGAATCAATCAAGCTGAATACAATTTTAAAGAACGTATTTTAAGCAGCGAACGTTTAGCTAAAATAATGATGAGTGAATTAGGCGATAAGAGACAGGAACACCTTATTGCTATATATCTTGACACTCAAAATCGTGTGATAAAAAAACAAGTCATTTTTATTGGCAGCGTCAGACGATCTGTTGCTGAACCCCGAGAAATCCTTCATTATGCTTGTAAAAGTATGGCAACATCACTTATTATTGTCCATAATCATCCTTCAGGTTCAACTTATCCAAGCGAGAATGACCTGCGATTTACAGAAAAAATAAAACGATCCTGTGATGATTTAGGAATCGTCTTTTTAGATCATATTATTGTCGGGAAAAAAGAATATTACAGTTTTCGTGAGGAAACAGATCTTGTTTAA","7.10","0.36","23938","MTYGPESLSNQELLAILLRTGTKKEHVLNLSIKILNGLDSLADFRSLSLEELQEIEGIGQVRSVEIKAMLELSKRINQAEYNFKERILSSERLAKIMMSELGDKRQEHLIAIYLDTQNRVIKKQVIFIGSVRRSVAEPREILHYACKSMATSLIIVHNHPSGSTYPSENDLRFTEKIKRSCDDLGIVFLDHIIVGKKEYYSFREETDLV","1000432","For other 'rad' genes see SMu0293 (radA). From Genbank:[gi:13878681]This protein is involved in DNA repair.","DNA repair protein RadC","Cytoplasm, Membrane","Several matches in gapped BLAST to DNA repair protein: residues1-208 are 63% similar to the protein in S.pyogenes (gi15675098). Residues 4-209 are 58% similar to the protein from S.pneumoniae (gi15900956).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1101 (3e-84).","

InterPro
IPR001405
Family

DNA repair protein RadC
PD007415	$\"[112-170]T$	RadC
PF04002	$\"[84-208]T$	RadC
TIGR00608	$\"[1-208]T$	radc
PS01302	$\"[157-162]?$	RADC

InterPro
IPR010994
Domain

RuvA domain 2-like
SSF47781	$\"[33-71]T$	RuvA_2_like

noIPR
unintegrated

unintegrated
SSF102712	$\"[84-209]T$	SSF102712

","BeTs to 5 clades of COG2003COG name: DNA repair proteins, RadC familyFunctional Class: LThe phylogenetic pattern of COG2003 is -----qvcEb-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB001405 (DNA repair protein radC family) with a combined E-value of 1.5e-14. IPB001405 130-170","Residues 4-59 are 57% similar to a (REPAIR DNA HOMOLOG) protein domain (PD013117) which is seen in RADC_LACLA.Residues 106-163 are 56% similar to a (REPAIR DNA HOMOLOG RADC-LIKE) protein domain (PD007415) which is seen in RADC_LACLA.Residues 166-204 are 64% similar to a (REPAIR DNA HOMOLOG RADC-LIKE) protein domain (PD253901) which is seen in RADC_LACLA.Residues 65-162 are 31% similar to a (REPAIR DNA HOMOLOG) protein domain (PD414563) which is seen in RADC_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 31 15:49:00 2006","Mon Jul 31 15:49:00 2006","Mon Jul 31 15:49:00 2006","Tue Jan 29 15:04:03 2002","Tue Jan 29 15:04:03 2002","Tue Jan 29 15:04:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0963 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 15:04:03 2002","","No significant hits to the NCBI PDB database.","SMU.1055c","","Residues 84 to 208 (E-value = 1.6e-70) place SMu0963 in the RadC family which is described as RadC, DNA repair protein (PF04002)","Tue Jan 29 15:04:03 2002","","","","Levin,P.A., Margolis,P.S., Setlow,P., Losick,R. and Sun,D.Identification of Bacillus subtilis genes for septum placement andshape determinationJ. Bacteriol. 174 (21), 6717-6728 (1992)PubMed: 1400224Butler,Y.X., Abhayawardhane,Y. and Stewart,G.C.Amplification of the Bacillus subtilis maf gene results in arrested septum formationJ. Bacteriol. 175 (10), 3139-3145 (1993)PubMed: 8387996","","Tue Jan 29 15:13:41 2002","1","","","SMU.1055c","683" "SMu0965","1001933","1001196","738","ATGACTAAACTAAATGTTATATCACAGTTTTTGTCAGGTAATCCTGTCTTAACGCTCCTTTTGATAGCTCATTTTTTGGCTGATTTTCAGTGGCAAAGCCAGAAAATGGCTGATTTAAAATCTTCCAACTGGACTTATCTTATCAGACATCTTATCATTGTTGCTTTACCTTTAATACTACTTAGTGTTGTGATTCCTCATTCTTTTTTGGTATTATCTTTGATTTTTCTTAGTCATGTTCTTATTGATAGTGGCAAATTACTGTTAAACTCGTTCTATAAGGATAGGTCATTTATCAAAACTAAAGCTGTTTTTCTTATTGATCAAAGTCTGCATATCATTATGATGATTATCTTTTATCAATTTTATACAAAAGTAAGTATAAACTGGCTTAGTGATTTTCAGTATTTTTTAAAGTTAATGCTGTTTCTTATTCTCATCACTAAACCAGTAAATATTATTTTTAAGCTTTTCTTTAGTAAATATCAAGTTAAAGATAATATTGAAGATGAAACCATTACAGGGGCTGGTGCGACGATTGGCTTATTAGAGCGATTGATTATGGGAATTTTTCTCTTATTTGGACAATTCGCTTCCATTGGTTTAGTGTTTACAGCGAAATCTATTGCTCGTTATGATAAAATTGCTAAGAATCAAGCTTTTGCAGAATACTATCTTATCGGTTCTCTATTTAGTATTATTTGTGTTTTAATCATTTATGCTATCTGTTTAATCTAA","10.10","8.09","28071","MTKLNVISQFLSGNPVLTLLLIAHFLADFQWQSQKMADLKSSNWTYLIRHLIIVALPLILLSVVIPHSFLVLSLIFLSHVLIDSGKLLLNSFYKDRSFIKTKAVFLIDQSLHIIMMIIFYQFYTKVSINWLSDFQYFLKLMLFLILITKPVNIIFKLFFSKYQVKDNIEDETITGAGATIGLLERLIMGIFLLFGQFASIGLVFTAKSIARYDKIAKNQAFAEYYLIGSLFSIICVLIIYAICLI","1001210","For other 'sat' genes see SMu0966 (satD) and SMu0967 (satC).","acid tolerance protein","Membrane, Cytoplasm","Matches in gapped BLAST to SatE and conserved hypothetical proteins:residues 1-108 are 100% similar to the previously published protein SatE in S.mutans (gi|11055965|). Residues 4-243 are 51% similar to conserved hypothetical protein in S.pyogenes (gi|15675144|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0980 (2e-64).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-33]?$	signal-peptide
tmhmm	$\"[10-28]?$ $\"[43-63]?$ $\"[69-89]?$ $\"[104-124]?$ $\"[134-154]?$ $\"[190-210]?$ $\"[224-244]?$	transmembrane_regions

InterPro
IPR002197
Domain

Helix-turn-helix, Fis-type
PR01590	$\"[39-56]T$ $\"[180-200]T$	HTHFIS

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-222 are identical to a (SATD) protein domain (PD312763) which is seen in Q9F2G1_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 11:12:49 2002","Tue Oct 15 11:12:49 2002","Tue Oct 15 11:12:49 2002","Tue Jan 29 15:30:21 2002","","Tue Jan 29 15:30:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0966 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 15:38:15 2002","","No significant hits to the NCBI PDB database.","SMU.1058c","","No significant hits to the Pfam 11.0 database","Tue Jan 29 15:30:21 2002","","","Kremer,B.H.A., van Der Kraan,M., Crowley,P.J., Hamilton,I.R.,Brady,L.J. and Bleiweis,A.S.Characterization of the sat Operon in Streptococcus mutans:Evidence for a Role of Ffh in Acid ToleranceJ. Bacteriol. 183 (8), 2543-2552 (2001)PubMed: 11274114Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P.and Bleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 8763945Gutierrez,J.A., Crowley,P.J., Cvitkovitch,D.G., Brady,L.J.,Hamilton,I.R., Hillman,J.D. and Bleiweis,A.S.Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved inresistance to acid stressMicrobiology 145 (Pt 2), 357-366 (1999)PubMed: 10075418","","Thu Mar 21 10:21:17 2002","","1","","10","SMU.1058c","" "SMu0967","1003222","1002695","528","ATGAATCATTTAAATCAAACCTATAATAGTATAAAATATCGTTATAATGGTCTTCCCAATAAAATACAAATTATAATCATTGCTTTATCAGTTAGCCTCATTTATATTTTACCTTTATTGACTATTAGTAATGGAGTCTTAAATGGCGATGACCTGCATTTTCGTATTGATAGAATGTTGGGTTTATCTAGCATATGGAAAAGTCCGGTTAATTTTAGGACTTTTTACAAAGTTGGGCAGGGAGTGAATTATTTTTATCCTTTTTACAGATATAAAGGACAAGTGGTAACAGTAGATAATCGGTTGGTATCTTCTGCTTTAAGCAAATCAGGATCAACTGCTATTCATTTACCTAATGGTATTCATGAAATTAGGGTTACTTATTATTATACTGCAGTAGCAAGAGTAGCATTTGTCACATCCATCATTGTCATTATCGTAACTATAATCTATGCTGTTTTGTATCATTTGATTGAAAAACATAGGATTACTTTTAAGATCAGACAAGGTTTATTTATCTATTATTAA","10.80","13.42","20186","MNHLNQTYNSIKYRYNGLPNKIQIIIIALSVSLIYILPLLTISNGVLNGDDLHFRIDRMLGLSSIWKSPVNFRTFYKVGQGVNYFYPFYRYKGQVVTVDNRLVSSALSKSGSTAIHLPNGIHEIRVTYYYTAVARVAFVTSIIVIIVTIIYAVLYHLIEKHRITFKIRQGLFIYY","1002709","For other 'sat' genes see SMu0965 (satE) and SMu0966 (satD).","acid tolerance protein","Membrane, Cytoplasm","Only matches in gapped BLAST to SatC:residues 1-175 are 92% similar to the previously published protein in S.mutans (gi|11055963|). SMu0967 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-49]?$	signal-peptide
tmhmm	$\"[22-42]?$ $\"[138-158]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-175 are 92% similar to a (SATC) protein domain (PD306304) which is seen in Q9F2G2_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 11:13:25 2002","Tue Oct 15 11:13:25 2002","Tue Oct 15 11:13:25 2002","Tue Jan 29 15:44:10 2002","","Tue Jan 29 15:44:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0967 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 15:45:13 2002","","No significant hits to the NCBI PDB database.","SMU.1059c","","No significant hits to the Pfam 11.0 database","Tue Jan 29 15:44:10 2002","","","Kremer,B.H.A., van Der Kraan,M., Crowley,P.J., Hamilton,I.R.,Brady,L.J. and Bleiweis,A.S.Characterization of the sat Operon in Streptococcus mutans:Evidence for a Role of Ffh in Acid ToleranceJ. Bacteriol. 183 (8), 2543-2552 (2001)PubMed: 21172871Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P.andBleiweis,A.S. Insertional mutagenesis and recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminary characterization of mutants displaying acid sensitivity and nutritional requirements J. Bacteriol. 178 (14), 4166-4175 (1996) PubMed: 8763945 Gutierrez,J.A., Crowley,P.J., Cvitkovitch,D.G., Brady,L.J., Hamilton,I.R., Hillman,J.D. and Bleiweis,A.S. Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit ofthe signal recognition particle, is involved in resistance to acid stress Microbiology 145 (Pt 2), 357-366 (1999) PubMed: 10075418 ","","Thu Mar 21 10:23:54 2002","","1","","10","SMU.1059c","" "SMu0968","1004792","1003242","1551","ATGGCTTTTGAAAGTTTAACCGAACGTTTACAAGGTGTCTTTAAAAATTTACGCGGCAAACGCAAACTCTCTGAAAAAGATGTACAGGAAGTCACCAAAGAAATCCGCCTCGCTTTATTAGAAGCTGATGTCGCCTTACCTGTCGTTAAAGAATTTATTAAGCGTGTTCGTAAACGCGCTGTTGGACATGAGGTTATTGATACCTTAGATCCTTCCCAACAAATCATTAAAATTGTTAACGAAGAACTGACAGCAGTCCTCGGCTCTGAAACGGCTGAAATTGAAAAATCGTCTAAAATTCCAACCATTATCATGATGGTCGGTCTTCAAGGGGCTGGTAAAACCACTTTTGCTGGCAAACTTGCTAATAAGTTAGTTAAAGAAGAAAATGCACGTCCTCTGATGATTGCTGCTGATATTTACCGACCGGCTGCTATTGACCAGTTAAAAACTTTGGGACAACAAATTAATGTACCTGTTTTTGACATGGGGACAGAGCATTCAGCAGTTGAGATTGTAAGTCAAGGTCTGGCTCAAGCCAAAGAAAATCGTAACGACTATGTTTTAATTGATACAGCCGGCCGTTTACAAATTGATGAGAAATTAATGACTGAGCTGCGTGATATCAAAGCTTTAGCCAATCCTAATGAAATTCTCTTGGTTGTTGATAGTATGATCGGTCAAGAAGCCGCAAATGTTGCACGCGAATTCAACCAACAATTAGAGGTCACTGGGGTTATCCTTACAAAAATTGATGGTGATACTCGCGGTGGTGCTGCGCTTTCCGTCCGTCAAATCACTGGAAAACCAATTAAATTCACTGGTACTGGCGAAAAGATTACCGATATTGAAACCTTCCATCCAGATCGCATGTCCTCTCGGATTTTGGGAATGGGAGACTTGCTTACCTTAATTGAGAAGGCTAGTCAGGATTACGATGAACAAAAATCAGCTGAATTAGCTGAAAAAATGCGCGAGAATTCCTTTGACTTCAATGATTTCATTGAACAATTAGATCAAGTTCAAAACATGGGATCAATGGAAGATATTCTTAAAATGATTCCTGGTATGGCTAACAATCCAGCTCTTGCCAATGTCAAAGTTGATGAAGGTGAAATTGCTAGAAAACGCGCCATCGTATCATCAATGACACCTGAAGAACGTGAGAATCCTGACCTCCTAACTCCGAGCCGCAGACGTCGTATTGCTTCTGGTTCTGGTAATACTTTTGTTAATGTCAATAAATTCATCAAAGATTTTAATCAGGCTAAGAAGATGATGCAAGGTGTCATGTCTGGTGATATGAATAAGGTCATGAAACAAATGGGGATTAATCCTAATAATATGCCTAAAAACATGGACTCATCAGCTCTTGAAGGAATGATGGGACAAGGCGGTATGCCAGATATGTCAGAGTTGAGCGGTACTAATATGGATGTGAGTCAAATGTTTGGTGGGGGACTTAAAGGTAAGGTCGGCGAATTTGCTATGAAACAATCTATGAAGAAAATGGCTAAAAGAATGAAAAAAGCCAAAAAACGTAAAAAATAA","9.60","4.78","57063","MAFESLTERLQGVFKNLRGKRKLSEKDVQEVTKEIRLALLEADVALPVVKEFIKRVRKRAVGHEVIDTLDPSQQIIKIVNEELTAVLGSETAEIEKSSKIPTIIMMVGLQGAGKTTFAGKLANKLVKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTEHSAVEIVSQGLAQAKENRNDYVLIDTAGRLQIDEKLMTELRDIKALANPNEILLVVDSMIGQEAANVAREFNQQLEVTGVILTKIDGDTRGGAALSVRQITGKPIKFTGTGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQDYDEQKSAELAEKMRENSFDFNDFIEQLDQVQNMGSMEDILKMIPGMANNPALANVKVDEGEIARKRAIVSSMTPEERENPDLLTPSRRRRIASGSGNTFVNVNKFIKDFNQAKKMMQGVMSGDMNKVMKQMGINPNNMPKNMDSSALEGMMGQGGMPDMSELSGTNMDVSQMFGGGLKGKVGEFAMKQSMKKMAKRMKKAKKRKK","1003256","From Genbank [gi:2500883]:This protein is necessary for efficient export of extra-cytoplasmic proteins.it binds to the signal sequence when it emerges from the ribosomes.See also the comments of Kremer et al., 2001, concerning acid tolerance; see 'sat' operon. ","signal recognition particle","Cytoplasm, Membrane","Matches in gapped BLAST to signal recognition particle protein :residues 1-500 are 99% similar to the previously published protein in S.mutans (gi2500883). See also GI:56968645.Residues 1-500 are 86% similar to the protein from S.pneumoniae (gi15901147).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0982 (0.0).","

InterPro
IPR000897
Domain

GTP-binding signal recognition particle SRP54, GTPase
PD000819	$\"[104-195]T$	SRP54
PF00448	$\"[100-297]T$	SRP54
PS00300	$\"[270-283]T$	SRP54

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[100-248]T$	AAA

InterPro
IPR004125
Domain

GTP-binding signal recognition particle SRP54, M-domain
G3DSA:1.10.260.30	$\"[328-432]T$	SRP54_M
PF02978	$\"[328-427]T$	SRP_SPB

InterPro
IPR004780
Family

Signal recognition particle protein
PTHR11564:SF7	$\"[75-500]T$	SRP_sub
TIGR00959	$\"[3-429]T$	ffh

InterPro
IPR013822
Domain

GTP-binding signal recognition particle SRP54, helical bundle
G3DSA:1.20.120.140	$\"[2-91]T$	SRP54_helical
PF02881	$\"[3-88]T$	SRP54_N
SSF47364	$\"[3-89]T$	SRP54

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[94-299]T$	G3DSA:3.40.50.300
PTHR11564	$\"[75-500]T$	PTHR11564
SSF47446	$\"[299-431]T$	SSF47446
SSF52540	$\"[96-297]T$	SSF52540

","BeTs to 17 clades of COG0541COG name: Signal recognition particle GTPase FfhFunctional Class: NThe phylogenetic pattern of COG0541 is amtkyqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000897 (GTP-binding signal recognition particle (SRP54) domain) with a combined E-value of 5.3e-73. IPB000897A 103-122 IPB000897B 135-149 IPB000897C 186-206 IPB000897D 215-257 IPB000897E 270-297","Residues 418-500 are 96% similar to a (RECOGNITION SIGNAL PARTICLE FFH) protein domain (PD106142) which is seen in SR54_STRMU.Residues 28-296 are 99% similar to a (SIGNAL RECOGNITION PARTICLE GTP-BINDING RNA-BINDING) protein domain (PD000819) which is seen in SR54_STRMU.Residues 297-417 are 99% similar to a (SIGNAL RECOGNITION PARTICLE GTP-BINDING) protein domain (PD001802) which is seen in SR54_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 10:28:14 2006","Thu Aug 3 10:28:14 2006","Tue Feb 1 10:40:50 2005","Tue Jan 29 15:50:19 2002","Tue Jan 29 15:50:19 2002","Tue Jan 29 15:50:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0968 is paralogously related (blast p-value < 1e-3) to SMu0676, a predicted cell division protein FtsY; signal recognition particle (docking protein).","Tue Jan 29 15:58:56 2002","Tue Feb 1 10:40:50 2005","pdb2FFHA Chain A, The Signal Sequence Binding Protein Ffh Fro... 346 4e-096pdb1FFH N And Gtpase Domains Of The Signal Sequence Recogn... 263 5e-071pdb2NG1 N And Gtpase Domains Of The Signal Sequence Recogn... 260 2e-070","SMU.1060c","","Residues 3 to 88 (E-value = 3.2e-33) place SMu0968 in the SRP54_N family which is described as SRP54-type protein, helical bundle domain (PF02881)Residues 100 to 297 (E-value = 1e-119) place SMu0968 in the SRP54 family which is described as SRP54-type protein, GTPase domain (PF00448)Residues 328 to 427 (E-value = 9.1e-54) place SMu0968 in the SRP_SPB family which is described as Signal peptide binding domain (PF02978)","Tue Feb 1 10:40:50 2005","",""," Hasona A, Zuobi-Hasona K, Crowley PJ, Abranches J, Ruelf MA, Bleiweis AS, Brady LJ.Membrane Composition Changes and Physiological Adaptation by Streptococcus mutans Signal Recognition Particle (SRP) Pathway Mutants.J Bacteriol. 2006 Nov 3;PMID: 17085548Crowley PJ, Svenster G, Snoep JL, Bleiweis AS, Brady LJ.An ffh mutant of Streptococcus mutans is viable and able to physiologically adapt to low pH in continuous culture.FEMS Microbiol Lett. 2004 May;234(2):315-24.PMID: 15135539Gutierrez,J.A., Crowley,P.J., Cvitkovitch,D.G., Brady,L.J.,Hamilton,I.R., Hillman,J.D. and Bleiweis,A.S.Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved inresistance to acid stressMicrobiology 145 (Pt 2), 357-366 (1999)PubMed: 8763945Kremer,B.H.A., van Der Kraan,M., Crowley,P.J., Hamilton,I.R.,Brady,L.J. and Bleiweis,A.S.Characterization of the sat Operon in Streptococcus mutans:Evidence for a Role of Ffh in Acid ToleranceJ. Bacteriol. 183 (8), 2543-2552 (2001)PubMed: 11274114Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P.andBleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 8763945 ","Nakamura,K., Nishiguchi,M., Honda,K. and Yamane,K.The Bacillus subtilis SRP54 homologue, Ffh, has an intrinsic GTPase activity and forms a ribonucleoprotein complex with smallcytoplasmic RNA in vivoBiochem. Biophys. Res. Commun. 199 (3), 1394-1399 (1994)PubMed: 7511896Dong HJ, Tao SM, Li YQ, Chan SH, Shen XL, Wang CX, Guan WJ.Analysis of the GTPase activity and active sites of the NG domains of FtsY and Ffh from Streptomyces coelicolor.Acta Biochim Biophys Sin (Shanghai). 2006 Jul;38(7):467-76.PMID: 16820862","Thu Aug 3 10:28:14 2006","Thu Aug 3 10:28:14 2006","1","","10","SMU.1060c","116" "SMu0969","1005237","1004905","333","ATGGAGATCGAAAAAACCAATCGAATGAATGCGCTTTTTGAATTTTATGCGGCGCTTTTGACAGATAAGCAAATGAATTATATTGAGCTATATTATGCAGATGATTATAGCTTAGCTGAAATTGCTGAAGAATTTGACGTTAGTCGCCAAGCTGTTTATGATAATATTAAGCGAACCGAAAAAATTTTAGAAGACTATGAAATGAAACTTCATATGTATTCTGACTACGTCGTCCGCAGTGAAATTTTTGATGCTATAATGAAAAAATATCCTAATGATCCTTATCTGCAGAACAAGATTTCCATATTGACGACTATTGATAATAGAGACTAA","4.30","-8.76","13236","MEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIAEEFDVSRQAVYDNIKRTEKILEDYEMKLHMYSDYVVRSEIFDAIMKKYPNDPYLQNKISILTTIDNRD","1004919","","DNA-binding protein","Cytoplasm","Matches in gapped BLAST to a previously published sequence in S.mutans:residues 1-110 are 100% similar to hypothetical,13.3 KDA protein in prox-ffh intergenic region (gi12643473).Residues 1-110 are 86% similar to conserved hypothetical protein from S.pneumoniae (gi15901148).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0983 (4e-51).","

InterPro
IPR007394
Family

Putative helix-turn-helix protein, YlxM/p13-like
PF04297	$\"[3-103]T$	UPF0122

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[2-110]T$	Wing_hlx_DNA_bd

InterPro
IPR013324
Domain

RNA polymerase sigma factor, regions 3 and 4
SSF88659	$\"[4-109]T$	Sigma_r3_r4

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 11-86 are identical to a (PROTEOME COMPLETE PROX-FFH A05_ORF102) protein domain (PD012592) which is seen in YLXM_STRMU.Residues 87-110 are identical to a (PROX-FFH) protein domain (PD218529) which is seen in YLXM_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 29 16:09:25 2002","Mon Jul 10 15:14:14 2006","Mon Jul 10 15:14:14 2006","Tue Jan 29 16:08:02 2002","","Tue Jan 29 16:08:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0969 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 29 16:09:25 2002","","No significant hits to the NCBI PDB database.","SMU.1061c","","Residues 3 to 103 (E-value = 8.7e-62) place SMu0969 in the UPF0122 family which is described as Putative helix-turn-helix protein, YlxM / p13 like (PF04297)","Tue Jan 29 16:08:02 2002","","","Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P. and Bleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 96312359Kremer,B.H.A., van Der Kraan,M., Crowley,P.J., Hamilton,I.R., Brady,L.J. and Bleiweis,A.S. Characterization of the sat Operon in Streptococcus mutans: Evidence for a Role of Ffh in Acid Tolerance J. Bacteriol. 183 (8), 2543-2552 (2001) PubMed: 11274114 Gutierrez,J.A., Crowley,P.J., Cvitkovitch,D.G., Brady,L.J., Hamilton,I.R., Hillman,J.D. and Bleiweis,A.S. Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit of the signal recognition particle, is involved in resistance to acid stress Microbiology 145 (Pt 2), 357-366 (1999) PubMed: 10075418 ","","Thu Mar 21 10:27:51 2002","","1","","10","SMU.1061c","800" "SMu0970","1007077","1005347","1731","TTGAATTTAATATTACAAGGAAAACTACCTGTTGCTGATTGGATTGAGGATTTGACCAACTGGTTGACACATACCTTTTCTGGTTTGTTTAATCTTATTCAGTCAGTCGGAAATTTTATTATGGATGGAATTACAAATACACTCTTATTTGTTAATCCTTTACTGTTAATTGTTCTAGTGACGCTTGCCGCCTTTTTCTTAGCTAGAAAAAAATGGACCTTACCAACTTTTACCTTATTGGGCTTGCTTTTTATCTATAATCAAAGTCTTTGGGATGATTTAGTCAACACTTTCACCTTAGTATTGGTATCTAGTTTTATTTCTATTGTGATTGGTATTCCTTTAGGAATTTGGATGGCAAAAAACAATACTGTCAAGCAAATTATCAATCCTATTTTGGATTTTATGCAAACTATGCCAGCCTTTGTTTATTTAATTCCTGCTGTCGCCTTCTTTGGTATCGGTATCGTACCTGGTGTTTTTGCATCTGTTATTTTTGCTTTGCCGCCTACCGTTCGTTTTACTAATCTTGCCATTCGTGAAATTCCAACGGAATTGATTGAGGCAGCTGATGCTTTTGGTAGTACTTCGCGCCAAAAATTATTTAAAGTTGAACTACCTCTTGCTAAAAATACAATTATGGCTGGTATCAATCAAACTATTATGCTGGCTCTCTCAATGGTAGTAACAGGATCTATGATCGGAGCCCCAGGGCTAGGTCGTGGTGTTTTATCTGCTTTACAACATGCTGATATCGGTTCAGGTTTTGTTAATGGACTTGCCTTGGTGATTTTAGCGATTGTTATTGACCGTTTTAGTCAGACCGCCAATCAAAGAACAAAAGATGCTAATCAAAAAAAGAACAAAACAAATACAATTATTGCTTTGGCTGCACTTGTTCTGTTTGTCTTTGCGGGAATTGCCCGACTCTTTGTTCAAGGACAATCAGCAGGTGGCGGTCAAAAAATTAAATTATCCTATGTAGAATGGGATTCCGAAGTTGCTTCCACAAATGTTTTAGCTCAGGTCTTGAAAGATCAAGGATACAAAGTAGAAATGACTCCCCTTGATAATGCCGTTATGTGGCAGTCAGTATCTAAGGGTGAAACTGATGCAATGGTCAGTGCTTGGCTACCAAACACTCATGGTGATCAATATAAAAAATATAAGAATAACATCGTTGATTTAGGACCTAATCTTAAGGGAGTTAAATTAGGTCTAGCTGTACCAACTTACATGAAGAACGTTAATCGTATTGAAGATTTGACTGATCAAGCTGATAAAAAGATTACTGGTATCGAACCTGGTGCAGGCATCATGAAAGCTGCTAACAAAGCATTGAAATCCTACAGCAATTTATCAGATTGGAAATTGGTTTCTGCTTCGACAGGTGCAATGACAACAGCTTTGGATCAAGCATATAAGAATAAAAAAGATATTGTTGTAACTGCTTGGTCTCCACACTGGATGTTTGCTAAATATAAACTGAAATATCTAAAAGATTCGAAAAAAGATTTTGGTAGTATTGAAAGCATTCATTCTATTACACGAAAAGGTCTGAAGAAAGATATACCAAAAGCAAATAAAATTATTGACAAGTTCAATTGGACGCAAAAAGACATGGAAGCAGTAATGCTTGACATCAATAATGGTATGTCTCCAGAAAAAGCAGCTAAAAAATGGATTAAAGAACATCCTAAGAAGGTTGCATCTTGGACAAGTAATAAATAA","10.40","20.45","63380","MNLILQGKLPVADWIEDLTNWLTHTFSGLFNLIQSVGNFIMDGITNTLLFVNPLLLIVLVTLAAFFLARKKWTLPTFTLLGLLFIYNQSLWDDLVNTFTLVLVSSFISIVIGIPLGIWMAKNNTVKQIINPILDFMQTMPAFVYLIPAVAFFGIGIVPGVFASVIFALPPTVRFTNLAIREIPTELIEAADAFGSTSRQKLFKVELPLAKNTIMAGINQTIMLALSMVVTGSMIGAPGLGRGVLSALQHADIGSGFVNGLALVILAIVIDRFSQTANQRTKDANQKKNKTNTIIALAALVLFVFAGIARLFVQGQSAGGGQKIKLSYVEWDSEVASTNVLAQVLKDQGYKVEMTPLDNAVMWQSVSKGETDAMVSAWLPNTHGDQYKKYKNNIVDLGPNLKGVKLGLAVPTYMKNVNRIEDLTDQADKKITGIEPGAGIMKAANKALKSYSNLSDWKLVSASTGAMTTALDQAYKNKKDIVVTAWSPHWMFAKYKLKYLKDSKKDFGSIESIHSITRKGLKKDIPKANKIIDKFNWTQKDMEAVMLDINNGMSPEKAAKKWIKEHPKKVASWTSNK","1005361","For other components see SMu0971 (NBD1).For other 'bus' genes see SMu0972 (busR). ","glycine-betaine binding ABC transporter permease","Membrane, Cytoplasm","Matches in gapped BLAST to glycinebetaine-binding protein:residues 440-576 are 89% similar to the previously published enzyme in S.mutans (gi1850605). Residues 1-573 are 66% similar to the protein from S.pyogenes (gi15674389).Residues 7-572 are 57% similar to the protein from Lactococcus lactis (gi15673433). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1796 (0.0).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[94-282]T$	BPD_transp_1
PS50928	$\"[94-273]T$	ABC_TM1

InterPro
IPR007210
Domain

Substrate-binding region of ABC-type glycine betaine transport system
PF04069	$\"[321-564]T$	OpuAC

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[314-572]T$	no description
tmhmm	$\"[47-67]?$ $\"[72-90]?$ $\"[100-120]?$ $\"[141-161]?$ $\"[220-240]?$ $\"[255-273]?$ $\"[292-312]?$	transmembrane_regions

","BeTs to 6 clades of COG1174COG name: Proline/glycine betaine ABC-type transport systems, permease componentsFunctional Class: EThe phylogenetic pattern of COG1174 is A-------EBR-uj--o----Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 169-240 are 80% similar to a (TRANSPORT PERMEASE COMPLETE TRANSMEMBRANE) protein domain (PD001159) which is seen in Q9KIF6_LACLA.Residues 330-572 are 60% similar to a (TRANSPORT GLYCINE BETAINE PROTEOME) protein domain (PD017714) which is seen in Q9KIF6_LACLA.Residues 226-271 are 56% similar to a (TRANSPORT SYSTEM GLYCINE PERMEASE) protein domain (PD057513) which is seen in Q9HTI7_PSEAE.Residues 7-94 are 34% similar to a (TRANSPORT TRANSMEMBRANE OPUABC BINDING) protein domain (PD407194) which is seen in Q9RQ05_BBBBB.Residues 100-168 are 79% similar to a (TRANSPORT PERMEASE ABC COMPLETE) protein domain (PD068741) which is seen in Q9KIF6_LACLA.Residues 178-270 are 32% similar to a (PROTEOME SYSTEM COMPLETE TRANSPORT) protein domain (PD057558) which is seen in O69723_MYCTU.Residues 241-289 are 58% similar to a (OPUABC BINDING TRANSPORT PERMEASE) protein domain (PD348396) which is seen in Q9RQ05_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 13 10:44:22 2007","Tue Mar 13 10:44:22 2007","Tue Mar 13 10:44:22 2007","Tue Jan 29 16:16:30 2002","","Tue Jan 29 16:16:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0970 is paralogously related (blast p-value < 1e-3) to SMu1002,a predicted amino acid ABC transport permease; SMu1921 and SMu1923,both predicted glycine betaine / carnitine / choline ABC transporter permease, SMu1038,a predicted phosphate ABC transporter (permease protein); SMu0595,a predicted ABC transporter, permease protein/possible taurine transport system permease protein; SMu1039,a predicted phosphate ABC transporter; SMu0886 and SMu0885, both predicted spermidine / putrescine ABC transporter (permease protein); and SMu0732, a predicted amino acid ABC transporter, permease protein-glutamine transport.","Tue Jan 29 16:33:18 2002","","No significant hits to the NCBI PDB database.","SMU.1062c","","Residues 94 to 282 (E-value = 4.9e-35) place SMu0970 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)Residues 322 to 574 (E-value = 3.4e-85) place SMu0970 in the OpuAC family which is described as Substrate binding domain of ABC-type glycine betaine transport system (PF04069)","Tue Mar 13 10:44:22 2007","","","Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P. and Bleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 96312359Kremer,B.H.A., van Der Kraan,M., Crowley,P.J., Hamilton,I.R., Brady,L.J. and Bleiweis,A.S. Characterization of the sat Operon in Streptococcus mutans: Evidence for a Role of Ffh in Acid Tolerance J. Bacteriol. 183 (8), 2543-2552 (2001) PubMed: 11274114 Gutierrez,J.A., Crowley,P.J., Cvitkovitch,D.G., Brady,L.J., Hamilton,I.R., Hillman,J.D. and Bleiweis,A.S. Streptococcus mutans ffh, a gene encoding a homologue of the 54 kDa subunit ofthe signal recognition particle, is involved in resistance to acid stress Microbiology 145 (Pt 2), 357-366 (1999) PubMed: 10075418 ","van der Heide,T. and Poolman,B.Osmoregulated ABC-transport system of Lactococcus lactis senseswater stress via changes in the physical state of the membraneProc. Natl. Acad. Sci. U.S.A. 97 (13), 7102-7106 (2000)PubMed: 10860977","Thu Mar 21 10:29:19 2002","Tue Jan 29 16:25:38 2002","1","","","SMU.1062c","" "SMu0971","1008294","1007080","1215","TTGAATAAACTTGAAATAAAACATCTCACCAAAATTTTTGGTAAAAAACAAAAAGCAGCACTTGAGATGATTAAAGAACAAAAAAGTAAAACGGAAATACTTGAAAAAACAGGAGCAACTGTTGGTGTCTATGATGTTAGTTTTGATGTCAAAGAAGGAGAAGTCTTTGTTATTATGGGGCTCTCTGGATCTGGGAAATCAACCCTGGTGCGTCTTTTGAATCGTTTGATTGAACCTTCTTCAGGAGATGTTTATATTAATGGTAAAGACATTGCTAAAATGAATACAGAAGAACTTCGTGAAGCGAGACGTCACACTCTTAACATGGTTTTTCAAAACTTTGGACTCTTTCCCCATAAAACAATCTTGGAAAATACAGAATTCGGTTTAGAATTAAGAGGAGTTCCTAAAGAAGAATGTATTGAATTAGCTGAACGTGCTCTTGATAATTCTAATCTTTTAGCTTTTAAAGATCAATATCCTAGTCAGCTGTCTGGAGGAATGCAGCAACGCGTCGGCTTAGCGCGCGCTCTTGCTAATGATCCAGAAATTCTATTGATGGATGAAGCTTTTTCCGCACTTGATCCTTTGATTCGTAAGGAAATGCAAGATGAGTTGTTAGACTTACAAGAAAAAGTGCAAAAAACGATCATTTTCATCACCCACGATTTAAACGAAGCACTTAGAATTGGTGATCGTATCGCTCTTATGAAAGATGGTCAAATCATGCAAATAGGTACCGGAGAAGAGATCCTAACGAAACCGGCCAATGATTTCGTTCGCGAATTCGTTGAAGATGTTGATCGTTCTAAAGTTCTAACAGCTCAGAATATTATGATTAAGCCTTTAACAACAGCTGTTGAAACAGATGGTCCCCAAGTCGCTCTCACAAGAATGCATAATGAGGAAGTTAGTATGTTAATGGCAACTAATCGTCGTCGTCAATTGATGGGGTCACTTTCAGCCGAAGCTGCTATTGAGGCCAGACGTAAGGGGCTTTCTTTAAAGGAGGCCGTTGATCCTAACGTTCGAACTGTTTCTAAAGATACAGTTATTACGGATATTATGCCTTTAATCTATGATTCTGCTGCACCGATTGCAGTGACAGATGATAATAATCGTCTATTAGGTGTTATCATTAAAGGTCGAGTTATTGAAGCTCTCGCTAATACAAAGGATGATACAGATACAGAAGCAGAAGGAGAGGAAGAATAG","4.90","-13.79","45022","MNKLEIKHLTKIFGKKQKAALEMIKEQKSKTEILEKTGATVGVYDVSFDVKEGEVFVIMGLSGSGKSTLVRLLNRLIEPSSGDVYINGKDIAKMNTEELREARRHTLNMVFQNFGLFPHKTILENTEFGLELRGVPKEECIELAERALDNSNLLAFKDQYPSQLSGGMQQRVGLARALANDPEILLMDEAFSALDPLIRKEMQDELLDLQEKVQKTIIFITHDLNEALRIGDRIALMKDGQIMQIGTGEEILTKPANDFVREFVEDVDRSKVLTAQNIMIKPLTTAVETDGPQVALTRMHNEEVSMLMATNRRRQLMGSLSAEAAIEARRKGLSLKEAVDPNVRTVSKDTVITDIMPLIYDSAAPIAVTDDNNRLLGVIIKGRVIEALANTKDDTDTEAEGEEE","1007094","For other components see SMu0970 (MSD1).For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762 (atmD); SMu1002 (atmE); SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA) ; SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).","amino acid ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to amino acid ABC transport ATP-binding protein:residues 35-283 are 34% similar to the previously published protein in S.mutans (gi|15625431|). Residues 4-390 are 83% similar to the protein from S.pyogenes (gi|15674388|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1797 (0.0).","

InterPro
IPR000644
Domain

Cystathionine-beta-synthase
PF00571	$\"[277-389]T$	CBS
SM00116	$\"[342-389]T$	CBS

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[163-206]T$	Q8DU84_STRMU_Q8DU84;
PF00005	$\"[53-240]T$	ABC_tran
PS50893	$\"[21-264]T$	ABC_TRANSPORTER_2
PS00211	$\"[164-178]T$	ABC_TRANSPORTER_1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[52-249]T$	AAA

InterPro
IPR005892
Family

Glycine betaine/L-proline transport ATP-binding subunit
TIGR01186	$\"[35-401]T$	proV: glycine betaine/L-proline transport A

InterPro
IPR013153
Domain

PrkA AAA
SM00763	$\"[9-306]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-273]T$	no description
PTHR19222	$\"[4-13]T$ $\"[38-285]T$	ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF48	$\"[4-13]T$ $\"[38-285]T$	GLYCINE BETAINE/L-PROLINE ABC TRANSPORTER

","BeTs to 5 clades of COG1125COG name: ABC-type proline/glycine betaine transport systems, ATPase componentsFunctional Class: EThe phylogenetic pattern of COG1125 is a-------EBr-uj--o----Number of proteins in this genome belonging to this COG is 3","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.3e-33. IPB001140A 42-88 IPB001140B 161-199 IPB001140C 217-246","Residues 248-390 are 55% similar to a (TRANSPORT ATP-BINDING OPUAA CBS) protein domain (PD021831) which is seen in Q9KIF7_LACLA.Residues 43-297 are 21% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 208-247 are 65% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9HU89_PSEAE.Residues 134-227 are 35% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in Q9CCF9_MYCLE.Residues 103-161 are 50% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9RR46_LISMO.Residues 35-250 are 29% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 109-161 are 47% similar to a (ATP-BINDING TRANSPORT TRANSPORTER) protein domain (PD052375) which is seen in Y412_METJA.Residues 208-243 are 55% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472) which is seen in Q9KHT9_LISMO.Residues 208-247 are 82% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9KIF7_LACLA.Residues 109-137 are 82% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496) which is seen in Q9KIF7_LACLA.Residues 43-94 are 67% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9RR46_LISMO.Residues 163-206 are 97% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9KIF7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 13:48:45 2002","Wed Oct 23 13:38:34 2002","Tue Oct 15 11:25:41 2002","Tue Jan 29 16:40:39 2002","Tue Jan 29 16:40:39 2002","Tue Jan 29 16:40:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0971 is paralogously related (blast p-value < 1e-3) to SMu1920, SMu1003, SMu0884, SMu0849, SMu1762, SMu0517, SMu0805, SMu1428, SMu1380, SMu1950, SMu0731, SMu0418, SMu0218, SMu0594, SMu1288, SMu1246, SMu1231, SMu1068, SMu1517, SMu0235, SMu0786, SMu1036, SMu0916, SMu0234, SMu1751, SMu1210, SMu1079, SMu0390, SMu0258, SMu0335, SMu1518, SMu1710, SMu1949, SMu1037, SMu1757, SMu1001, SMu0907, SMu0944, SMu1316, SMu0752, SMu0950, SMu0825, SMu0374, SMu0976, SMu1023, SMu1065, SMu1724, SMu0824, SMu0476, SMu0216, SMu1064, SMu0836, SMu0475, SMu0837, SMu0987, SMu1649, SMu0596, SMu0986, SMu0024, SMu0164, SMu1545, SMu1050, SMu1410, SMu0666, SMu1093, SMu1959, SMu1811, SMu0224, SMu0729, SMu1306, and SMu0823, all with ATP binding capabilities.","Tue Jan 29 16:43:56 2002","Tue Jan 29 16:40:39 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 176 3e-045pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 134 2e-032","SMU.1063c","","Residues 53 to 240 (E-value = 1.7e-68) place SMu0971 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jan 29 16:40:39 2002","",""," Abranches J, Lemos JA, Burne RA.,Osmotic stress responses of Streptococcus mutans UA159.FEMS Microbiol Lett. 2006 Feb;255(2):240-6. PMID: 16448501Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267, 4631-4637 (1992)PubMed: 1537846Russell RR, Ferretti JJNucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans.J Gen Microbiol 1990 May;136 ( Pt 5):803-10PubMed: 2380687PMID: 2380687Aduse-Opoku J, Tao L, Ferretti JJ, Russell RRBiochemical and genetic analysis of Streptococcus mutans alpha-galactosidase.J Gen Microbiol 1991 Apr;137 ( Pt 4):757-64PubMed: 1649890PMID: 1649890Ferretti JJ, Huang TT, Russell RRSequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.Infect Immun 1988 Jun;56(6):1585-8PubMed: 2967248PMID: 2967248","Obis,D., Guillot,A., Gripon,J.C., Renault,P., Bolotin,A. andMistou,M.Y.Genetic and biochemical characterization of a high-affinity betaine uptake system (BusA) in Lactococcus lactis reveals a new functional organization within bacterial ABC transportersJ. Bacteriol. 181 (20), 6238-6246 (1999)PubMed: 10515910Bouvier,J., Bordes,P., Romeo,Y., Fourcans,A., Bouvier,I. andGutierrez,C.Characterization of OpuA, a glycine-betaine uptake system ofLactococcus lactisJ. Mol. Microbiol. Biotechnol. 2 (2), 199-205 (2000)PubMed: 10939245","Tue Apr 2 17:19:05 2002","Tue Jan 29 16:49:22 2002","1","","","SMU.1063c","" "SMu0972","1009199","1008567","633","ATGGAAACAAAAGAAAGAATGATTAGCAGTCCTCGTTATCAAAAGGTGGCTATTGGGATTGCTCAGCGAATTGTTGATGGGAAATTTCCCTTAGGACAAAAAATAAAATCACGTTCAACTTTAGCCAGCTATTTTAATGTCTCGCCTGAAACAGCCAGAAAAGCCATTAATGTTTTAGCAGATTTAGATATTGTTTCAGTCAGGCAAGGCAGCGGCGTTATTGTTATCTCGAGAGATAAAGCAATAGAATATTTAGAAAAATTTGAAGCAACAGCAGGCTTAAAAGAAATGAAGCAGGATATTCAAAGAAGCCTGTTAAAACAAAAACAAGAGCTTGATGCTATGAATAAAATGATGGATACTTTTTTATCGCAAGCTAGCCTCATTCGTAAAAAGTTTCCTTTTGAACCTTTTGAACTTTTATTGGATCATGATAGTGCTAATCTTAATAAAAGTTTGGCAGATTTAAATTTATGGCATCAGACAGGAGCAACTGTTGTGGCTCTTAAAAGTAAGGGAGAATTACTTTTATCCCCCGGCCCATACGCGACTGTCAGAAAAGGAGATATCCTTTACTTTGTTGGAGATGACTTTGCTTTTTCACGGATGAAAAATCTTTTTGACATCTTATGA","10.20","6.48","23618","METKERMISSPRYQKVAIGIAQRIVDGKFPLGQKIKSRSTLASYFNVSPETARKAINVLADLDIVSVRQGSGVIVISRDKAIEYLEKFEATAGLKEMKQDIQRSLLKQKQELDAMNKMMDTFLSQASLIRKKFPFEPFELLLDHDSANLNKSLADLNLWHQTGATVVALKSKGELLLSPGPYATVRKGDILYFVGDDFAFSRMKNLFDIL","1008581","For other 'bus' genes see SMu0970 (busAB). ","transcriptional regulator","Periplasm, Cytoplasm","Several matches in gapped BLAST to transcriptional regulators: residues 1-209 are 44% similar to the protein in S.pyogenes (gi|15675218|). Residues 6-207 are 45% similar to the protein from Lactococcus lactis (gi|15081315|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1134 (5e-57).","

InterPro
IPR000524
Domain

Bacterial regulatory protein GntR, HTH
PF00392	$\"[12-75]T$	GntR
SM00345	$\"[16-75]T$	HTH_GNTR
PS50949	$\"[10-78]T$	HTH_GNTR

InterPro
IPR006037
Domain

TrkA-C
PF02080	$\"[137-208]T$	TrkA_C
PS51202	$\"[123-209]T$	RCK_C

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[5-75]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[9-79]T$	SSF46785
SSF51735	$\"[135-208]T$	SSF51735

","BeTs to 5 clades of COG1226COG name: Eukaryotic-type potassium channelsFunctional Class: PThe phylogenetic pattern of COG1226 is AMTKyQvCEbr-uj-------Number of proteins in this genome belonging to this COG is 2","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 3.1e-09. IPB000524 35-75","Residues 139-195 are 56% similar to a (COMPLETE PROTEOME CHANNEL POTASSIUM) protein domain (PD013953) which is seen in Q9CFL6_LACLA.Residues 13-77 are 40% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD371622) which is seen in EXUR_ERWCH.Residues 6-137 are 43% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD397327) which is seen in Q9CFL6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 11:26:19 2002","Wed Jan 30 08:16:47 2002","Tue Oct 15 11:26:19 2002","Wed Jan 30 08:16:47 2002","Wed Jan 30 08:16:47 2002","Wed Jan 30 08:16:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0972 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 30 08:17:31 2002","","No significant hits to the NCBI PDB database.","SMU.1064c","","Residues 12 to 75 (E-value = 9.4e-10) place SMu0972 in the GntR family which is described as Bacterial regulatory proteins, gntR family (PF00392)Residues 137 to 208 (E-value = 2.4e-11) place SMu0972 in the TrkA_C family which is described as TrkA-C domain (PF02080)","Wed Jan 30 08:16:47 2002","24379501","","","","","","1","","","SMU.1064c","" "SMu0973","1009901","1009203","699","ATGTTACCGGCTTATATTCGCATTCATGATCAAATCAAAAAAGAAATCGATGAAGGTCTTTGGAAAATCGGCGATCGTCTTCCTAGCGAACGTGATTTGGCAGAACGATTTGAAGTTAGCCGAATGACGCTTCGACAGGCTATAACACTCCTTGTTGAAGAAGGGATTTTAGAGCGTCGAGTGGGAAGCGGTACTTACATCGCTAGCAGTCGTGTTCAAGAAAAAATGCGTGGGACAACTAGTTTTACAGAAATTGTAAAATCACAAGGCAAAACACCTTCGACCAAATTAATTTCTTACCGGCGGGTTCATCCAAGCGAACAAGAAATAAAATTTTTAGATATTAAACCTAAATCTTATATTATCCGAATGGAGCGAGTTCGCTATGCAGATGATATTCCTGTTGTTTTTGAAGTGACAGCTATTCCTGAAAAGATTATTAAGAGTTTCAAAAAGGAAGCTATTACCAAGCATTTCTTTAAAACGTTGACAGATCATGGTTTTGTTATCGGAAAAAGTCAGCAAACCATTTCTGCCAGTAATGCTAATGAGATGACGGCTGATTATTTGGCGATCTCGCGTGGACATGCAGTACTAACCTTGGCTCAAGTTTCCTATTTTGAAAATGGTATGCCTTTTGAATATGTCCGCAGCCAATATGTCGGTGAGCGTTTTGAGTTTTATTTAGAAAATAAGTAA","10.10","6.22","26808","MLPAYIRIHDQIKKEIDEGLWKIGDRLPSERDLAERFEVSRMTLRQAITLLVEEGILERRVGSGTYIASSRVQEKMRGTTSFTEIVKSQGKTPSTKLISYRRVHPSEQEIKFLDIKPKSYIIRMERVRYADDIPVVFEVTAIPEKIIKSFKKEAITKHFFKTLTDHGFVIGKSQQTISASNANEMTADYLAISRGHAVLTLAQVSYFENGMPFEYVRSQYVGERFEFYLENK","1009217","","transcriptional regulator, GntR family","Cytoplasm","Several matches in gapped BLAST to transcriptional regulators, GntR family: residues 1-231 are 71% similar to the protein in S.pneumoniae (gi15901296) and are 66% similar to the protein from S.pyogenes (gi15675167).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0968 (1e-91).","

InterPro
IPR000524
Domain

Bacterial regulatory protein GntR, HTH
PR00035	$\"[27-41]T$ $\"[41-57]T$	HTHGNTR
PF00392	$\"[4-67]T$	GntR
SM00345	$\"[8-67]T$	HTH_GNTR
PS50949	$\"[2-70]T$	HTH_GNTR

InterPro
IPR011663
Domain

UbiC transcription regulator-associated
PF07702	$\"[88-226]T$	UTRA

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[5-70]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
PTHR11751	$\"[8-68]T$	PTHR11751
PTHR11751:SF1	$\"[8-68]T$	PTHR11751:SF1
SSF46785	$\"[1-74]T$	SSF46785

","BeTs to 3 clades of COG2188COG name: Transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG2188 is --------EBr----------Number of proteins in this genome belonging to this COG is 1","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 5.5e-24. IPB000524 27-67***** IPB001034 (Bacterial regulatory protein, DeoR family) with a combined E-value of 5.2e-06. IPB001034A 28-63","Residues 12-68 are 50% similar to a (TRANSCRIPTIONAL REGULATOR DNA-BINDING) protein domain (PD000726) which is seen in Q9RYU6_DEIRA.Residues 5-67 are 52% similar to a (REGULATOR AMINOTRANSFERASE PROTEOME) protein domain (PD389999) which is seen in Q9KFQ9_BACHD.Residues 89-227 are 53% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD004095) which is seen in Q9CFN0_LACLA.Residues 12-88 are 35% similar to a (TRANSCRIPTIONAL REGULATION REGULATOR) protein domain (PD173107) which is seen in O88047_STRCO.Residues 3-67 are 43% similar to a (PROTEOME TRANSCRIPTIONAL FAMILY REGULATOR) protein domain (PD407521) which is seen in Q9KA96_BACHD.Residues 2-67 are 46% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD371622) which is seen in O34817_BACSU.Residues 5-87 are 36% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD410995) which is seen in Q9HXN8_PSEAE.Residues 19-77 are 81% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD069824) which is seen in Q9CFN0_LACLA.Residues 12-71 are 41% similar to a (REPRESSOR DNA-BINDING REGULATION) protein domain (PD053669) which is seen in HUTC_KLEAE.Residues 12-67 are 42% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD389722) which is seen in UXUR_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 08:26:45 2002","Wed Jan 30 08:25:33 2002","Tue Aug 29 17:51:50 2006","Wed Jan 30 08:25:33 2002","Wed Jan 30 08:25:33 2002","Wed Jan 30 08:25:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0973 is paralogously related (blast p-value < 1e-3) to SMu1853,a predicted trehalose operon transcriptional repressor (transcriptional regulator,GntR family); SMu0582,a predicted transcriptional regulator;SMu0865,a predicted conserved hypothetical protein; possible transcriptional regulator, and SMu1092, also a predicted transcriptional regulator (GntR family).","Wed Jan 30 08:33:47 2002","","No significant hits to the NCBI PDB database.","SMU.1065c","","Residues 4 to 67 (E-value = 2.2e-24) place SMu0973 in the GntR family which is described as Bacterial regulatory proteins, gntR family (PF00392)","Wed Jan 30 08:25:33 2002","24379502","","","","","","1","","","SMU.1065c","554" "SMu0974","1010105","1011658","1554","ATGACTGATATTAAAGATATTCAAAAAATTATCGTACTTGACTACGGCAGTCAGTACAATCAGCTGATCGCACGCCGCATTCGTGAATTTGGTATTTTTTCTGAATTGAGAAGCCATAAGGTAACAGCCGACGAAGTCCGTGCTATCAATCCAATTGGTATTGTCCTTTCAGGAGGACCAAGTTCAGTTTATGCTGAAGATGCCTTTGACATTGATAAGGAAATCCTTGATCTTGGAATCCCCGTTTTAGGTATTTGTTATGGTATGCAGCTTCTTACAGAAAAACTTGGCGGTAAAGTTGTTCCTGCTGGACAAACTGGCAATAGTGAATATGGTCAGTCTACACTTCATTTGACAGAAAACTCAGAGCTTTTTAAGGAAACTCCTGCTGAACAAACTGTTTTGATGAGCCATGGCGATGCTGTTACTGAAATTCCCGAAGGCTTTCAATTGGTTGGCAAATCAAGCGACTGCCCTTATGCTGCCATTGAAAATGTCGAAAAGAAAATCTTTGGCATTCAATTTCACCCAGAAGTTCGTCATACGGAATATGGTAATGCGATTTTACGCAATTTTGCTTTTAATGTTTGTAAAGCCAAAGGTGATTGGTCAATGGACAGTTTCATTGATATGGAAATTGAAAAAATCCGTGAACAAGTTGGTAATCGTAAGGTTCTTCTGGGGCTTTCGGGCGGTGTGGACTCTTCTGTTGTTGGCGTGCTTTTGCAAAAAGCTATAGGTGACCAATTAACCTGTATCTTCGTTGATCATGGCCTTCTTCGTAAGGGTGAAGGCGATCAGGTTATGGAAATGTTGGGTGGTAGATTTGGACTCAATATTATTCGTGTTGATGCTTCCAAACGCTTTTTGGATCTTCTTGCTGGTATTGATGATCCTGAGAAAAAGCGTAAAATCATTGGGAATGAATTTGTCTATGTTTTTGATGATGAAGCCAGCAAACAAAAAGGCGTTGATTTCTTGGCACAAGGAACGCTTTATACAGATGTCATCGAATCCGGCACAGAAACAGCCCAAACCATTAAATCACACCACAATGTCGGTGGTCTTCCAGAAGACATGCAGTTTGAATTAATAGAGCCGTTAAACACACTGTTCAAGGATGAAGTTCGTACTCTGGGGACTGCTTTAGGAATGCCAGATGAAATCGTTTGGCGGCAACCATTTCCAGGACCTGGACTTGCCATTCGGGTGATGGGAGAAATTACTGCTGAAAAACTTGAAACGGTTCGTGAATCTGACGCTATTTTACGCGAAGAAATTGCTGCAGCAGGCCTGAATCGTGATATTTGGCAATATTTTACTGTCAATACTGGCGTTCGTTCAGTCGGAGTTATGGGAGATGGTCGTACCTATGACTATACCATCGCTATTCGCGCCATCACTTCTATTGACGGCATGACAGCAGACTTTGCCCGTATTCCTTGGGAGGTTCTCCAAAAGATCTCTGTTCGTATTGTCAACGAAGTGGAACACGTCAACCGCATCGTCTACGACATTACCAGCAAACCACCAGCAACTGTTGAGTGGGAATAA","4.70","-22.96","57253","MTDIKDIQKIIVLDYGSQYNQLIARRIREFGIFSELRSHKVTADEVRAINPIGIVLSGGPSSVYAEDAFDIDKEILDLGIPVLGICYGMQLLTEKLGGKVVPAGQTGNSEYGQSTLHLTENSELFKETPAEQTVLMSHGDAVTEIPEGFQLVGKSSDCPYAAIENVEKKIFGIQFHPEVRHTEYGNAILRNFAFNVCKAKGDWSMDSFIDMEIEKIREQVGNRKVLLGLSGGVDSSVVGVLLQKAIGDQLTCIFVDHGLLRKGEGDQVMEMLGGRFGLNIIRVDASKRFLDLLAGIDDPEKKRKIIGNEFVYVFDDEASKQKGVDFLAQGTLYTDVIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRTLGTALGMPDEIVWRQPFPGPGLAIRVMGEITAEKLETVRESDAILREEIAAAGLNRDIWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFARIPWEVLQKISVRIVNEVEHVNRIVYDITSKPPATVEWE","1011666","For other 'gua' genes see SMu0962 (guaA) and SMu1957 (guaB). ","GMP synthase","Cytoplasm","Several matches in gapped BLAST to GMP synthase: residues 4-517 are 82% similar to the enzyme in S.pyogenes (gi|15675169|). Residues 2-517 are 80% similar to the protein from S.pneumoniae (gi|15901295|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0967 (0.0).","

InterPro
IPR000991
Domain

Glutamine amidotransferase class-I
PF00117	$\"[11-196]T$	GATase

InterPro
IPR001317
Domain

Carbamoyl-phosphate synthase, GATase region
PR00099	$\"[10-24]T$ $\"[51-65]T$ $\"[81-97]T$	CPSGATASE

InterPro
IPR001674
Domain

GMP synthase, C-terminal
PF00958	$\"[424-516]T$	GMP_synt_C
TIGR00884	$\"[207-517]T$	guaA_Cterm

InterPro
IPR003694
Domain

NAD+ synthase
PF02540	$\"[221-249]T$	NAD_synthase

InterPro
IPR004739
Domain

GMP synthase, N-terminal
TIGR00888	$\"[10-200]T$	guaA_Nterm

InterPro
IPR006220
Domain

Anthranilate synthase component II/delta crystallin
PR00097	$\"[54-63]T$ $\"[81-92]T$ $\"[172-185]T$	ANTSNTHASEII

InterPro
IPR011702
Domain

Glutamine amidotransferase superfamily
PR00096	$\"[54-63]T$ $\"[81-92]T$ $\"[172-185]T$	GATASE

InterPro
IPR012998
Active_site

Glutamine amidotransferase, class I, active site
PS00442	$\"[81-92]T$	GATASE_TYPE_I

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[202-392]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.300.10	$\"[409-517]T$	G3DSA:3.30.300.10
G3DSA:3.40.50.880	$\"[8-201]T$	G3DSA:3.40.50.880
PTHR11922	$\"[9-517]T$	PTHR11922
PTHR11922:SF2	$\"[9-517]T$	PTHR11922:SF2
SSF52317	$\"[4-235]T$	SSF52317
SSF52402	$\"[188-439]T$	SSF52402

","BeTs to 14 clades of COG0519COG name: GMP synthase - PP-ATPase domainFunctional Class: FThe phylogenetic pattern of COG0519 is amtkyqvcebrhuj--o--n-Number of proteins in this genome belonging to this COG is 1","***** IPB001674 (GMP synthase C terminal domain) with a combined E-value of 2.5e-230. IPB001674A 10-36 IPB001674B 81-90 IPB001674C 134-146 IPB001674D 171-192 IPB001674E 224-264 IPB001674F 283-315 IPB001674G 326-339 IPB001674H 352-406 IPB001674I 438-477 IPB001674J 481-517***** IPB000991 (Glutamine amidotransferase class-I) with a combined E-value of 7.8e-11. IPB000991A 81-90 IPB000991B 170-180***** IPB003694 (NAD+ synthase) with a combined E-value of 2.4e-09. IPB003694A 226-245","Residues 243-305 are 77% similar to a (GMP BIOSYNTHESIS AMIDOTRANSFERASE) protein domain (PD034321) which is seen in GUAA_LACLA.Residues 162-197 are 61% similar to a (GLUTAMINE SYNTHASE AMIDOTRANSFERASE BIOSYNTHESIS GMP) protein domain (PD348302) which is seen in GUAA_LACLC.Residues 161-222 are 51% similar to a (GMP AMIDOTRANSFERASE GLUTAMINE) protein domain (PD253514) which is seen in GUAA_LACRH.Residues 53-161 are 63% similar to a (GMP GLUTAMINE AMIDOTRANSFERASE) protein domain (PD004928) which is seen in GUAA_LACLC.Residues 43-104 are 47% similar to a (CARBAMOYL-PHOSPHATE SYNTHASE SYNTHETASE SMALL CHAIN) protein domain (PD105693) which is seen in CARA_PSEAE.Residues 163-221 are 41% similar to a (GMP SYNTHASE AMIDOTRANSFERASE GLUTAMINE) protein domain (PD344914) which is seen in GUAA_CHLMU.Residues 7-51 are 82% similar to a (GMP AMIDOTRANSFERASE GLUTAMINE) protein domain (PD408681) which is seen in GUAA_LACLC.Residues 306-517 are 88% similar to a (GMP BIOSYNTHESIS AMIDOTRANSFERASE) protein domain (PD003340) which is seen in GUAA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 11:27:38 2002","Wed Jan 30 08:39:48 2002","Tue Oct 15 11:27:38 2002","Wed Jan 30 08:39:48 2002","Wed Jan 30 08:39:48 2002","Wed Jan 30 08:39:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0974 is paralogously related (blast p-value < 1e-3) to SMu0484, a predicted anthranilate synthase component II; SMu1158,a predicted amidotransferase and SMu0783, a predicted carbamoyl phosphate synthetase,small subunit.","Wed Feb 27 09:46:27 2002","Wed Jan 30 08:39:48 2002","pdb|1GPM|A Chain A, Escherichia Coli Gmp Synthetase Complexed W... 492 3e-140","SMU.1066","","Residues 11 to 196 (E-value = 1.7e-53) place SMu0974 in the GATase family which is described as Glutamine amidotransferase class-I (PF00117)Residues 397 to 516 (E-value = 1.1e-67) place SMu0974 in the GMP_synt_C family which is described as GMP synthase C terminal domain (PF00958)","Wed Jan 30 08:39:48 2002","24379503","","","Duwat,P., Ehrlich,S.D. and Gruss,A.Effects of metabolic flux on stress response pathways inLactococcus lactisMol. Microbiol. 31 (3), 845-858 (1999)PubMed: 10048028","","Wed Jan 30 08:56:35 2002","1","","","SMU.1066","114" "SMu0975","1012572","1011784","789","ATGACCATACTATATCATGAAATAAAATCAAATTGGCGTACCTTACTTATCTGGTCTCTCAGTATCGGCATCTTTTCTTGTGCTTGTATCCTGCTGTTTGATAATGTCGCTGATGGTATGAAAGATGTTGCAACTTCTTTTTCCAAAATGGGGAGTTTTTCGACAGCTTTTGGTATGAATAAACTCAATATTTCTACTTTAAATGGTTATTATGCAACACAAATCGCTATGATTGTTGCTATTGGCGGTGCTATGTTTGCTGGTATGACTGGAGCTCTCATGCTTTCTAAGGAAGAAGAAGGACACACAGCAGAGTTTCTCTACACCTTGCCACTTAGCAGGACCTCTATTGTTGTAAAGAAATATTTCAGTCTCTTTATATTAGTTGCCCTTTTTAATGTTATTGTCATGGGACTCGACTTATTAGCTCTTGTCTATCTAGGAAAATCATTTGATTTTGATGCTTACTATATCTATCATCTGTTTGCCTTTTTAATGCAACTTGAGATAGCTAGTATTTGCTTTATGATTTCTGCAATAAGTAAACGAAAACCAATCGGCTTAGCGTTAGGAATCGCTATTATGGCTTACTTATTGGATGTGATGTGCCGCATTATTCCCAAGATAAAATTTGTCAAATATGTCACTCCTTTTTATTATAGCAATGCCAGTGATATTTTTGTTAAGACTAAGCCAGCAGCTATCCATATAATAATCGCTTGTCTTGTTATTATATGCTCTTTTATCATCTCACTTTTAATCAATCAATCGCGTGATATTAGTAGTTAA","8.70","5.66","29128","MTILYHEIKSNWRTLLIWSLSIGIFSCACILLFDNVADGMKDVATSFSKMGSFSTAFGMNKLNISTLNGYYATQIAMIVAIGGAMFAGMTGALMLSKEEEGHTAEFLYTLPLSRTSIVVKKYFSLFILVALFNVIVMGLDLLALVYLGKSFDFDAYYIYHLFAFLMQLEIASICFMISAISKRKPIGLALGIAIMAYLLDVMCRIIPKIKFVKYVTPFYYSNASDIFVKTKPAAIHIIIACLVIICSFIISLLINQSRDISS","1011798","For other components see SMu0976 (NBD1).","ABC transporter, permease protein","Membrane, Cytoplasm","Limited weak matches in gapped BLAST to ABC transporter, permease proteins: residues 1-226 are 23% similar to the enzyme in Thermotoga maritima (gi|15643787|). Residues 1-229 are 26%similar to the protein from Listeria innocua (gi|16801143|).SMu0975 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-27]?$	signal-peptide
tmhmm	$\"[15-33]?$ $\"[67-87]?$ $\"[122-142]?$ $\"[156-176]?$ $\"[186-206]?$ $\"[234-254]?$	transmembrane_regions

","BeTs to 5 clades of COG1277COG name: Predicted membrane proteinFunctional Class: SThe phylogenetic pattern of COG1277 is a--K--vC-B-----Pol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 52-226 are 26% similar to a (PROTEOME TRANSPORTER COMPLETE ABC) protein domain (PD359681) which is seen in Q9X0B9_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:10:40 2002","Wed Jan 30 09:02:57 2002","Tue Oct 15 11:28:15 2002","Wed Jan 30 09:02:57 2002","","Wed Jan 30 09:02:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0975 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Apr 26 08:36:27 2002","","No significant hits to the NCBI PDB database.","SMU.1067c","","No significant hits to the Pfam 11.0 database","Wed Jan 30 09:02:57 2002","24379504","","","","","","1","","","SMU.1067c","" "SMu0976","1013413","1012553","861","ATGGAACATTCATCAAAAGCAACGGTTCTTGAAATAGAGCATCTGCAAAAATATTATAAGAAAAATATTGGGGTTAAAGATATTTCTTTATCTGTCAAAAAAGGAGAGATTTTTGGTTTTCTTGGATCAAATGGTGCAGGAAAGTCAACGACTATTCGCTGTCTCTTGGGGCTGATTAAGCCAAGTGGTGGTCAGATGACACTTTTCGGAGGTCGTTATGGATCGCTGACTGAAAGCCTCCATCATATTGGTTATATGCCATCGGAAGCCATGTTTTATCCAACCATGAAAGTTAAAGATGTTATCGCATTTGCAGCTAAAGTTCGTAAAAAAGACTGTAGCCAAGAGGCCAAACGCTTGTCTGAACTTTTAGAGGTTCCTTCAGATAAAAAAATAGAAGAACTATCTTTAGGAAATCGTAAAAAAGTTAGTATTGTCTGTGCCTTGCAGCATCAACCAGACCTTATTATTTTAGACGAACCAACATCAGGGTTAGACCCTTTAATGCAAGAGCGCTTTTTTAAATTGATTAAGGAAGCTTGTTCCAAAGGAGCTACTTGTTTCTTGTCCTCTCATGTTTTATCGGAAATTAAGAATTATTGTGATCGTGTTGCTATTCTTAAAAATGGTGAAATAGTAACTGTTGATGCTATTCATCATTTGACACACAGCATGTTGCGGAAAGTGTCTGTTTGGAAAGGCGGTAAGTTGAAGACTTTCAATTATAGCGGTTCTATGAAAGATTTGCTTAAACAGCTTGAGGAAATGAATCCTGATGATCTTTTGATAGAAGAACCATCACTGGAATCATTATTTTTACATTACTATGAGGAGAAAGACAATGACCATACTATATCATGA","8.00","4.38","32083","MEHSSKATVLEIEHLQKYYKKNIGVKDISLSVKKGEIFGFLGSNGAGKSTTIRCLLGLIKPSGGQMTLFGGRYGSLTESLHHIGYMPSEAMFYPTMKVKDVIAFAAKVRKKDCSQEAKRLSELLEVPSDKKIEELSLGNRKKVSIVCALQHQPDLIILDEPTSGLDPLMQERFFKLIKEACSKGATCFLSSHVLSEIKNYCDRVAILKNGEIVTVDAIHHLTHSMLRKVSVWKGGKLKTFNYSGSMKDLLKQLEEMNPDDLLIEEPSLESLFLHYYEEKDNDHTIS","1012567","For other components see SMu0975 (MSD1). ","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to ABC transporter, ATP-binding protein MutF :residues 9-219 are 31% similar to the previously published protein in S.mutans (gi9802352).Residues 8-278 are 41% similar to the protein from Thermotoga maritima (gi15643786). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0280 (5e-31).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[134-177]T$	ABC_transporter
PF00005	$\"[35-210]T$	ABC_tran
PS00211	$\"[135-149]?$	ABC_TRANSPORTER_1
PS50893	$\"[10-234]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[34-211]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-225]T$	G3DSA:3.40.50.300
PTHR19222	$\"[10-216]T$	PTHR19222
PTHR19222:SF16	$\"[10-216]T$	PTHR19222:SF16
SSF52540	$\"[9-224]T$	SSF52540

noIPR
unintegrated

unintegrated
tmhmm	$\"[15-37]?$ $\"[43-63]?$ $\"[83-101]?$ $\"[107-125]?$	transmembrane_regions

InterPro
IPR007492
Domain

LytTr DNA-binding region
PF04397	$\"[71-168]T$	LytTR
PS50930	$\"[65-169]T$	HTH_LYTTR

InterPro
IPR012360
Family

LytTR_ LMO transcriptional regulator, putative
PIRSF031486	$\"[24-171]T$	LMO_LytTR

InterPro
IPR010315
Family

Protein of unknown function DUF915, hydrolase-like
PF06028	$\"[31-283]T$	DUF915

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[41-280]T$	G3DSA:3.40.50.1820
SSF53474	$\"[41-282]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 43-281 are 23% similar to a (PROTEOME COMPLETE YUFC YRIC) protein domain (PD407861) which is seen in Q9CEV4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 10:27:06 2002","Wed Jan 30 10:25:08 2002","Wed Jan 30 10:27:06 2002","Wed Jan 30 10:25:08 2002","","Wed Jan 30 10:25:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0979 is paralogously related (blast p-value < 1e-3) to SMu0160, a conserved hypothetical.","Wed Jan 30 10:27:06 2002","","No significant hits to the NCBI PDB database.","SMU.1071c","","Residues 31 to 283 (E-value = 9.6e-138) place SMu0979 in the DUF915 family which is described as Bacterial protein of unknown function (DUF915) (PF06028)","Wed Jan 30 10:25:08 2002","24379508","","","","","","1","","","SMU.1071c","" "SMu0980","1015941","1015450","492","ATGAAAATAAGAAATGCTTGTAAAGAGGATGCCCAACAATTAATTGCTATTTATGCCTCCTATGTTGAAAAGACAGCTATTACCTTTGAATACCAAGTTCCTAGCCTAGAAGAATTTGAAGAACGTATCGAAAAAACAAAGCAAAAATTTCCTTATCTGGTTGCAGAAGAAGAGGGAATTCTGCAAGGTTATGCCTATGCTTCAGTTTATTATAATCATGCAGCTTATGATTGGACAGTTGAATTATCGATCTATATCAAAGAAGAAGCACGGGGTAAGCATATCGGCAGTCAACTTTATGCTAGTTTAGAAAGAAATTTGCAAGAAGCTGGTTTTGTTAATCTGTTGGTTTGCATTGCCTTACCCAACAACGCCAGCCTAACTTTTCATAAAAAGCACGGCTATGAACAAGTTGCCCATTTCAAAAAAGTCGGTTACAAATTTGATAAATGGTATGATATTGTTTGGATGCAAAAACGTTTGCTTGATTAA","6.70","-0.89","19105","MKIRNACKEDAQQLIAIYASYVEKTAITFEYQVPSLEEFEERIEKTKQKFPYLVAEEEGILQGYAYASVYYNHAAYDWTVELSIYIKEEARGKHIGSQLYASLERNLQEAGFVNLLVCIALPNNASLTFHKKHGYEQVAHFKKVGYKFDKWYDIVWMQKRLLD","1015464","","acyltransferase","Cytoplasm, Extracellular","Several matches in gapped BLAST to acyltransferase: residues 1-161 are 52% similar to the enzyme in Lactococcus lactis (gi15673759) . Residues 3-163 are 37% similar to the protein from Clostridium acetobutylicum (gi15894145).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1827 (3e-57).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[53-136]T$	Acetyltransf_1
PS51186	$\"[1-162]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[1-161]T$	G3DSA:3.40.630.30
SSF55729	$\"[1-161]T$	SSF55729

","BeTs to 3 clades of COG1247COG name: Sortase and related acyltransferasesFunctional Class: MThe phylogenetic pattern of COG1247 is -------ceb-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-51 are 58% similar to a (PROTEOME TRANSFERASE COMPLETE) protein domain (PD381026) which is seen in Q9CEQ9_LACLA.Residues 59-135 are 42% similar to a (RESISTANCE TRANSFERASE) protein domain (PD258150) which is seen in Q9KMG9_VIBCH.Residues 52-138 are 48% similar to a (COMPLETE PROTEOME TRANSFERASE) protein domain (PD350597) which is seen in Q9CEQ9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 10:32:55 2002","Wed Jan 30 10:30:41 2002","Mon Jul 17 17:12:44 2006","Wed Jan 30 10:30:41 2002","","Wed Jan 30 10:30:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0980 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 30 10:32:55 2002","","No significant hits to the NCBI PDB database.","SMU.1072c","","Residues 53 to 136 (E-value = 5.4e-12) place SMu0980 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Wed Jan 30 10:30:41 2002","24379509","","","Wohlleben,W., Arnold,W., Broer,I., Hillemann,D., Strauch,E. andPuhler,A.Nucleotide sequence of the phosphinothricin N-acetyltransferasegene from Streptomyces viridochromogenes Tu494 and its expressionin Nicotiana tabacumGene 70 (1), 25-37 (1988)PubMed: 3240868Schwartz,D., Alijah,R., Nussbaumer,B., Pelzer,S. and Wohlleben,W.The peptide synthetase gene phsA from Streptomycesviridochromogenes is not juxtaposed with other genes involved innonribosomal biosynthesis of peptidesAppl. Environ. Microbiol. 62 (2), 570-577 (1996)PubMed: 8593056","","Wed Jan 30 10:36:49 2002","1","","","SMU.1072c","859" "SMu0981","1017675","1016005","1671","ATGAAAACAGATATTGAAATTGCACAAAGTGTTGACTTGCGACCCATTACAAATGTTGTTAAAAAGTTAGGATTTGACTTTGATGATCTTGAACTTTATGGTAAATATAAGGCTAAATTGACTTTTGATAAGATTAAAGCGGTTGAAGAAAATGCACCCGGAAAACTTGTCTTAGTAACAGCTATTAATCCAACGCCGGCTGGTGAAGGGAAATCAACAATTACCATCGGGCTTGCAGATGCCCTTAATAAAATCGGCAAGAAAACAATGATTGCTATTCGTGAACCTTCCCTTGGTCCGGTTATGGGCATTAAAGGCGGCGCTGCTGGTGGTGGTTACGCTCAAGTTTTACCAATGGAAGATATCAATTTGCATTTTACAGGTGATATGCATGCTATTACGACAGCTAATAATGCTCTTTCAGCTCTTATTGACAACCATCTGCATCAGGGAAACGAATTGGGCATAGATCAACGTCGGATTATTTGGAAGCGCGTTGTCGATTTAAATGACCGTGCTCTTCGTCATGTTACAGTTGGTTTAGGCAGCCCTATAAATGGCATTCCACGTGAGGATGGTTTTGATATCACTGTAGCATCTGAAATCATGGCTATCCTTTGTTTGGCAACGAATGTTGAAGATCTAAAAGAACGCTTGGCCAACATCGTCATTGGTTATCGTTTTGATCGTAGTCCGGTTTACGTTCGTGATTTAGAAGTGCAAGGAGCACTGGCTCTTATCCTAAAAGAGGCTATCAAGCCTAACTTAGTACAAACGATTTATGGAACACCTGCTTTTGTCCACGGCGGTCCTTTCGCCAATATCGCTCATGGCTGCAATTCCGTCCTTGCAACTTCAACAGCTCTTCGTTTAGCGGATTATACTATAACAGAAGCTGGTTTCGGAGCTGATCTTGGTGCTGAAAAATTCCTTGATATCAAAGCACCAAACTTACCGACAAGCCCTGATGCGGTAGTTATCGTTGCAACTATTCGTGCCCTGAAGATGAATGGTGGTGTGGCTAAAGATGCTCTTAATCAAGAAAATGTTGAAGCGGTCAAGGCTGGTTTTGCCAATTTAGCACGTCATGTTGAAAATATGCGTAAATATGGCGTTCCTGTAGTAGTAGCTATCAATGAATTTATCACAGATACGAACGATGAAATTGCTGTTCTTCGTAACTTGTGTGCGGCTATCGATGTACCTGTTGAATTAGCCAGTGTCTGGGCTAACGGGGCTGATGGCGGTGTAGACTTGGCAAATACGCTTATCAATACCATTGAAAATAATCCATCCCATTATAAACGTCTTTATGATAATAATCTTTCAGTTGAAGAAAAAGTCACTGAGATTGCCAAGGAAATCTACCGTGCTGATAAAGTTATTTTTGAAAAGAAAGCTAAAACACAAATTGCCCAAATTGTTAAAAATGGTTGGGATAACTTACCAATTTGTATGGCTAAGACACAGTACAGTTTTTCAGACGATCCGAAATTACTGGGTGCCCCAACTGGCTTTGATATTACTATTCGTGAATTGGTTCCCAAGTTGGGTGCAGGTTTTATCGTTGCACTTACAGGAGATGTCATGACCATGCCTGGATTGCCAAAAAAACCAGCAGCTCTTAATATGGATGTTGCTGCAGATGGAACAGCCCTTGGCTTGTTCTAA","5.80","-6.98","59724","MKTDIEIAQSVDLRPITNVVKKLGFDFDDLELYGKYKAKLTFDKIKAVEENAPGKLVLVTAINPTPAGEGKSTITIGLADALNKIGKKTMIAIREPSLGPVMGIKGGAAGGGYAQVLPMEDINLHFTGDMHAITTANNALSALIDNHLHQGNELGIDQRRIIWKRVVDLNDRALRHVTVGLGSPINGIPREDGFDITVASEIMAILCLATNVEDLKERLANIVIGYRFDRSPVYVRDLEVQGALALILKEAIKPNLVQTIYGTPAFVHGGPFANIAHGCNSVLATSTALRLADYTITEAGFGADLGAEKFLDIKAPNLPTSPDAVVIVATIRALKMNGGVAKDALNQENVEAVKAGFANLARHVENMRKYGVPVVVAINEFITDTNDEIAVLRNLCAAIDVPVELASVWANGADGGVDLANTLINTIENNPSHYKRLYDNNLSVEEKVTEIAKEIYRADKVIFEKKAKTQIAQIVKNGWDNLPICMAKTQYSFSDDPKLLGAPTGFDITIRELVPKLGAGFIVALTGDVMTMPGLPKKPAALNMDVAADGTALGLF","1016019","From Genbank:[gi:1103865]This enzyme is involved in the formation of 10-formyl-tetrahydrofolate for purine, pyrimidine and amino acid biosynthesis.","formate--tetrahydrofolate ligase","Cytoplasm","Matches in gapped BLAST to formate--tetrahydrofolate ligase: residues 1-556 are 98% similar to the previously published enzyme in S.mutans (gi2501186). Residues 1-556 are 83% similar to the enzyme from S.pneumoniae R6(gi15458735) and are 76% similar to the enzyme from S.pyogenes (gi15675177).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1055 (0.0).","

InterPro
IPR000559
Domain

Formate-tetrahydrofolate ligase, FTHFS
PF01268	$\"[1-556]T$	FTHFS
PS00721	$\"[103-113]T$	FTHFS_1
PS00722	$\"[328-339]T$	FTHFS_2

noIPR
unintegrated

unintegrated
G3DSA:3.10.410.10	$\"[443-532]T$	G3DSA:3.10.410.10
G3DSA:3.40.50.300	$\"[2-442]T$	G3DSA:3.40.50.300
PTHR10025	$\"[1-556]T$	PTHR10025
SSF52540	$\"[4-554]T$	SSF52540

","BeTs to 3 clades of COG0630COG name: Predicted ATPases involved in pili biogenesisFunctional Class: NThe phylogenetic pattern of COG0630 is AMtK-QVCEbrhUJ----inxNumber of proteins in this genome belonging to this COG is 2","***** IPB000559 (Formate-tetrahydrofolate ligase) with a combined E-value of 0. IPB000559A 9-53 IPB000559B 54-82 IPB000559C 93-142 IPB000559D 143-183 IPB000559E 184-225 IPB000559F 242-292 IPB000559G 293-341 IPB000559H 348-388 IPB000559I 434-458 IPB000559J 478-510 IPB000559K 511-546","Residues 16-202 are 95% similar to a (LIGASE SYNTHASE SYNTHETASE) protein domain (PD003089) which is seen in FTHS_STRMU.Residues 476-535 are identical to a (LIGASE SYNTHETASE SYNTHASE) protein domain (PD186204) which is seen in FTHS_STRMU.Residues 203-471 are identical to a (LIGASE SYNTHASE SYNTHETASE) protein domain (PD341571) which is seen in FTHS_STRMU.Residues 154-201 are 56% similar to a (SYNTHASE SYNTHETASE) protein domain (PD371392) which is seen in Q9SPK5_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 10:48:33 2002","Wed Jan 30 10:46:01 2002","Thu Sep 28 10:34:47 2006","Wed Jan 30 10:44:42 2002","Wed Jan 30 10:44:42 2002","Wed Jan 30 10:44:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0981 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 30 10:46:01 2002","","No significant hits to the NCBI PDB database.","SMU.1073c","","No significant hits to the Pfam 11.0 database","Wed Jan 30 10:44:42 2002","","","Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P. and Bleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 8763945Crowley,P.J., Gutierrez,J.A., Hillman,J.D. and Bleiweis,A.S.Genetic and physiologic analysis of a formyl-tetrahydrofolatesynthetase mutant of Streptococcus mutansJ. Bacteriol. 179 (5), 1563-1572 (1997)PubMed: 9045814","Whitehead,T.R. and Rabinowitz,J.C.Nucleotide sequence of the Clostridium acidiurici ('Clostridiumacidi-urici') gene for 10-formyltetrahydrofolate synthetase showsextensive amino acid homology with the trifunctional enzymeC1-tetrahydrofolate synthase from Saccharomyces cerevisiaeJ. Bacteriol. 170 (7), 3255-3261 (1988)PubMed: 2838464","Wed Jan 30 10:47:20 2002","Fri Mar 16 12:27:15 2007","1","","","SMU.1073c","120" "SMu0982","1017842","1018528","687","ATGAAAATTTTGATTACATCTGGCGGGACGACTGAAAAGATCGATCAAGTAAGAGGAATCACTAATCATTCGTCAGGTCGCTTAGGAAAAAAAATAGCAGAGAAATTTTTGGCTGTCAATCATCAGGTTACTCTCGTTACCACAGCTTCTGCCATTAAACCAAAAAAACACGCTAATCTTTCAATTATAGAAATTACTGATGTTAACAACCTTATTGAGACTTTAGAGCCGCTGGTTAAATCTCATCATGTGCTGATTCATAGTATGGCAGTGTCCGATTATACACCACTTTACATGACTGATTTGGCAGAAATCGAAGAAACAAACGACCTTTCTCAGCTTCTAACTAAGACCAATAAAGAAAGAAAAATTTCATCACAGGCGGATTACCAAGTACTCTTTCTCAAAAAAACACCAAAGGTTATCAGTTTAGTCAAGCAATGGAACCCTAGCATACAATTAATCGCTTTTAAACTTCTGGTTAATGTCAGTAAAGAGGAGCTTTTTCAAGTCGCACGTAGCAGTTTAAAAAAGAATCAGGCGGATTATATTTTAGCTAATGATTTGACAATGATTTCAGCAGACAAACATCTGGCTTATCTTTTAGATGATACCAACGCCTACATGGCAGAAACAAAAGCTGAAATTGCCGATTTAATTTTTGAAAAGGTAAGAAAAAATGACTAA","9.40","3.69","25587","MKILITSGGTTEKIDQVRGITNHSSGRLGKKIAEKFLAVNHQVTLVTTASAIKPKKHANLSIIEITDVNNLIETLEPLVKSHHVLIHSMAVSDYTPLYMTDLAEIEETNDLSQLLTKTNKERKISSQADYQVLFLKKTPKVISLVKQWNPSIQLIAFKLLVNVSKEELFQVARSSLKKNQADYILANDLTMISADKHLAYLLDDTNAYMAETKAEIADLIFEKVRKND","1018536","","flavoprotein","Cytoplasm","Several matches in gapped BLAST to flavoprotein: residues 1-228 are 59% similar to the protein in S.pyogenes (gi|15675185|) and are 48% similar to the protein in Lactococcus lactis (gi|15672555|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1063 (4e-81).","

InterPro
IPR007085
Domain

DNA/pantothenate metabolism flavoprotein, C-terminal
PF04127	$\"[1-215]T$	DFP

InterPro
IPR011848
Family

Phosphopantothenate--cysteine ligase
TIGR02114	$\"[1-228]T$	coaB_strep

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10300	$\"[2-226]T$	G3DSA:3.40.50.10300
PTHR14359	$\"[2-96]T$ $\"[117-228]T$	PTHR14359
PTHR14359:SF6	$\"[2-96]T$ $\"[117-228]T$	PTHR14359:SF6
SSF102645	$\"[1-226]T$	SSF102645

","BeTs to 13 clades of COG0452COG name: Flavoprotein involved in panthothenate metabolismFunctional Class: HThe phylogenetic pattern of COG0452 is amtkYqvceBrhuj--o----Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 84-224 are 28% similar to a (FLAVOPROTEIN PROTEOME COMPLETE METABOLISM) protein domain (PD136292) which is seen in O27284_METTH.Residues 117-222 are 50% similar to a (FLAVOPROTEIN METABOLISM PROTEOME COMPLETE) protein domain (PD358418) which is seen in Q9CHZ5_LACLA.Residues 2-79 are 47% similar to a (FLAVOPROTEIN METABOLISM COMPLETE PROTEOME) protein domain (PD005411) which is seen in Q9CHZ5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 15:08:39 2002","Wed Jan 30 15:08:39 2002","Tue Oct 15 12:01:06 2002","Wed Jan 30 14:59:35 2002","","Wed Jan 30 14:59:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0982 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 30 14:59:35 2002","","No significant hits to the NCBI PDB database.","SMU.1074","","Residues 1 to 215 (E-value = 5.6e-54) place SMu0982 in the DFP family which is described as DNA / pantothenate metabolism flavoprotein (PF04127)","Wed Jan 30 14:59:35 2002","24379511","","","","","","1","","","SMU.1074","678" "SMu0983","1018521","1019060","540","ATGACTAAAAAAATTCTACTTGCTGTTTCTGGTAGCATTGCCGCTTATAAGGCTGCCGACCTAAGCCATCAATTAACCAAATTAGGCTATCATGTTAATGTCTTAATGACTAATGCCGCCAAACAGTTTATTCCCCCTTTAACCTTGCAAGTGCTTTCTAAAAATCCAGTTTATTCGAATGTTATGAAAGAGGATGATCCTCAAGTTATTAATCATATTGCATTGGCAAAACAAGCTGATCTATTTTTACTAGCACCTGCCTCTGCCAATACGCTTGCCCACCTTGCTCATGGTTTTGCAGATAATATAGTGACCAGTGTAGCTCTGGCTTTACCTTTAGAAGTTCCTAAATTTTTTGCCCCTGCTATGAATACTAAAATGTATGAGAATCCTATCACGCAAAGCAATATTGCCTTGCTAAAAAAATTCGGATATAAGGAAATCCAGCCCAAGTCAAGTGTACTAGCTTGCGGTGATGTCGGAAGCGGTGCTTTAGCAGATTTAGATACCATCATTCAAAAAATAGAAGAACAATTATAG","8.40","2.14","19266","MTKKILLAVSGSIAAYKAADLSHQLTKLGYHVNVLMTNAAKQFIPPLTLQVLSKNPVYSNVMKEDDPQVINHIALAKQADLFLLAPASANTLAHLAHGFADNIVTSVALALPLEVPKFFAPAMNTKMYENPITQSNIALLKKFGYKEIQPKSSVLACGDVGSGALADLDTIIQKIEEQL","1019068","","DNA/pantothenate metabolism flavoprotein","Membrane, Periplasm, Cytoplasm","Matches in gapped BLAST to DNA/pantothenate metabolism flavoprotein: residues 1-145 are 97% similar to the previously published protein in S.mutans (gi2833455). Residues 1-176 are 69% similar to the protein from S.pyogenes (gi15675186).Residues 5-179 are 62% similar to the protein from S.pneumoniae (gi15901093). This sequence is slightly similar to mutD, a bacteriocin modifying enzyme, from strain UA140 (see MI0006).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1064 (8e-68).","

InterPro
IPR003382
Domain

Flavoprotein
G3DSA:3.40.50.1950	$\"[1-179]T$	Flavoprotein
PF02441	$\"[3-122]T$	Flavoprotein
SSF52507	$\"[3-179]T$	Flavoprotein

InterPro
IPR011847
Family

Phosphopantothenoylcysteine decarboxylase
TIGR02113	$\"[3-179]T$	coaC_strep

noIPR
unintegrated

unintegrated
PTHR14359	$\"[9-179]T$	PTHR14359
PTHR14359:SF6	$\"[9-179]T$	PTHR14359:SF6

","BeTs to 13 clades of COG0452COG name: Flavoprotein involved in panthothenate metabolismFunctional Class: HThe phylogenetic pattern of COG0452 is amtkYqvceBrhuj--o----Number of proteins in this genome belonging to this COG is 2","***** IPB003382 (Flavoprotein) with a combined E-value of 2.5e-16. IPB003382 80-114","Residues 62-179 are 61% similar to a (FLAVOPROTEIN METABOLISM COMPLETE PROTEOME) protein domain (PD002847) which is seen in Q9CHZ6_LACLA.Residues 3-64 are 38% similar to a (FLAVOPROTEIN METABOLISM HOMOLOG) protein domain (PD389012) which is seen in DFP_MYCTU.Residues 5-58 are 72% similar to a (FLAVOPROTEIN METABOLISM PROTEOME COMPLETE) protein domain (PD005600) which is seen in Q9CHZ6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 15:15:15 2002","Wed Jan 30 15:20:03 2002","Thu May 5 11:28:32 2005","Wed Jan 30 15:14:06 2002","Wed Jan 30 15:14:06 2002","Wed Jan 30 15:14:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0983 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome. However it is similar to MI0006, a mutacin operon protease, in strain UA140.","Wed Apr 27 10:29:27 2005","Wed Apr 27 10:28:04 2005","pdb1E20A Chain A, The Fmn Binding Protein Athal3 109 3e-025","SMU.1075","","Residues 3 to 122 (E-value = 3.2e-54) place SMu0983 in the Flavoprotein family which is described as Flavoprotein (PF02441)","Wed Jan 30 15:14:06 2002","24379512","","Gutierrez,J.A., Crowley,P.J., Brown,D.P., Hillman,J.D., Youngman,P. and Bleiweis,A.S.Insertional mutagenesis and recovery of interrupted genes ofStreptococcus mutans by using transposon Tn917: preliminarycharacterization of mutants displaying acid sensitivity andnutritional requirementsJ. Bacteriol. 178 (14), 4166-4175 (1996)PubMed: 8763945","Spitzer ED, Jimenez-Billini HE, Weiss B.beta-Alanine auxotrophy associated with dfp, a locus affecting DNA synthesis in Escherichia coli.J Bacteriol. 1988 Feb;170(2):872-6.PMID: 3123465 ","Wed Jan 30 15:15:15 2002","Wed Jan 30 15:21:22 2002","1","","","SMU.1075","679" "SMu0984","1019135","1019707","573","ATGAAAAATCAAAAAAAGTCATCTAATATTGCTATTATTGCTGTTTTTTTCGCCGTAATGCTAGTTATTCATCTGCTTTCGAGTCTCATTTTTAACCTTTGGCCAGTCCCTATCAAACCAACAATTGTTCACATTCCTGTTATTGTTGCCTCTATTGTCTATGGTCCTCGTATTGGATCTGCCTTAGGAGGATTGATGGGAATCATCAGCCTTATTAATAATACTATTATTTTATTGCCGACAAGCTATCTGTTTTCTCCTTTTGTGCCGCATGGTAATTTCAACTCCTTACTCATAGCGCTTGTCCCTCGAATTTTAATTGGTATTTTTCCTTATTATATTTATAAATTAATGCAAAATCGCTTTGGACTTCTTTTAGCAGGCGCTATCGGTTCAGCGACTAATACTGTTTTTGTCCTCACAGGTATCTTTATTTTCTTTTCATCTGTTTACGGCGGCAATATCCAGACTATGTTGGCAACCATCATTTCTGCTAATTCTATTATTGAATTAATCATTTCAGCACTACTAACTTTCCTTATCGTTCCAAAATTGTTAAAACTTAAAAAATAA","11.10","11.69","20683","MKNQKKSSNIAIIAVFFAVMLVIHLLSSLIFNLWPVPIKPTIVHIPVIVASIVYGPRIGSALGGLMGIISLINNTIILLPTSYLFSPFVPHGNFNSLLIALVPRILIGIFPYYIYKLMQNRFGLLLAGAIGSATNTVFVLTGIFIFFSSVYGGNIQTMLATIISANSIIELIISALLTFLIVPKLLKLKK","1019715","","conserved hypothetical protein (possible membrane protein)","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypothetical and membrane protein: residues 3-190 are 55% similar to the protein in S.pyogenes (gi|15675187|). Residues 5-190 are 60% similar to the protein from S.pneumoniae (gi|15901094|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1065 (7e-63).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[40-58]?$ $\"[68-88]?$ $\"[94-114]?$ $\"[124-146]?$ $\"[162-182]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-183 are 41% similar to a (MEMBRANE PROTEOME YFGL COMPLETE) protein domain (PD103045) which is seen in Q9CHZ7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 12:03:57 2002","Tue Oct 15 12:03:57 2002","Tue Oct 15 12:03:57 2002","Wed Jan 30 16:09:56 2002","","Wed Jan 30 16:09:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0984 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 30 16:09:56 2002","","No significant hits to the NCBI PDB database.","SMU.1076","","No significant hits to the Pfam 11.0 database","Wed Jan 30 16:09:56 2002","24379513","","","","","","1","","","SMU.1076","805" "SMu0985","1019802","1021517","1716","ATGGTATATCAAGAAAATTATCAAAAATGGTTAGCTTATGCTAAACTTCCCGACTATCTTCATCAAGAATTATTAGCAATGGATGAAAAGACCAAGGAAGATGCTTTCTATACTAATCTTGAGTTTGGTACAGCGGGCATGCGTGGTTATATTGGCGCTGGAACTAATCGGATCAATATTTACGTCGTTCGTCAAGCAACTGAAGGACTTGCCCAATTGATTGAAACCAAAGGAGACGACGTCAAAAAACGCGGTGTTGCTATTGCTTACGATTCCCGTCATTTCTCTCAAGAATTCGCCTTTGAATCTGCTCAGGTTTTAGCAAAACACGGTATTAAAGCTTATGTCTTTGAATCTCTTCGTCCAACTCCAGAGTTATCATTTACTGTACGCCATTTAGGAACTTTTGCGGGTATTATGGTAACAGCCAGTCATAACCCTGCACCATTTAATGGTTACAAAGTTTATGGTGAAGATGGGGGACAAATGCCTCCTTTTGATGCGGATGCTCTAACAGATTTTATTCGTGCCATTAATGATCCATTTTCAATTGAATTAGCTGATTTAGAAGAAAGCAAAGCTTCTGGATTAATTGAAGTTATCGGTGAAGCTGTTGATACTGACTACCTCAAAGAAGTTAAAGATGTCAATATCAACCAAAAATTGATTGACGAGTACGGTAAAGACATGAAAATTGTCTACACCCCGCTTCATGGTACTGGTGAAATGCTGGCTCGTCGTGCTTTGGCACAAGCTGGTTTCGATTCTGTTCAAGTGGTTGAAGCTCAAGCAGTGCCAGACCCTGATTTTTCAACCGTTAAATCACCAAATCCAGAAAATCAAGAGGCTTTTCGTTTGGCTGAAGAATTAGGACGTCAGGTTGATGCTGATGTTCTCGTTGCAACCGATCCAGATGCGGATCGTCTTGGCGTTGAAATTCGCCAAGCTGATGGATCTTATAAGAATCTTTCTGGCAATCAAATCGGTGCTATCATCGCTAAGTACATTCTTGAAGCGCACAAAACGGCTGGAAGTTTACCTACTAATGCTGCTCTTTGTAAATCAATTGTATCAACTGAATTAGTTAGCAAAATTGCTGAAAGTTATGGCGCAACTATGTTTAATGTCTTGACTGGTTTCAAATTCATTGCTGAAAAGATTCAAGAATTCGAAGAAAAACACAACCACACTTACATGTTCGGCTTTGAAGAAAGCTTTGGTTACCTTATTAAACCTTTTGTTCGTGATAAAGACGCTATTCAAGCTGTGTTGATTGTTGCTGAAATCGCAGCCTACTATCGCTCACGCGGTTTAACACTTGCTGATGGCATTGATGAAATTTACAAAGAATACGGCTACTTCGCTGAAAAAACCATTTCAGTTACTCTGTCAGGTGTTGATGGCGCTACAGAGATTAAGAAAATCATGGATAAATTCCGTGGTGATGCTCCGAAACAATTTAACGCAACAGATGTCGTTAAATTAGAAGACTTCCAAGCTCAAACTGCTACAACTGCTGATGGTATTGAAAAATTAACGACTCCTCCAAGCAATGTTCTTAAATATATCCTATCAGATGCGTCTTGGATTGCTGTCCGTCCTTCAGGTACCGAGCCGAAAATCAAATTCTACATCGCAACTGTTGGTAATAATTCAGAAGATGCGCAAGTTAAAATTGCTAATATCGAAAAAGAAATCAATGATTTCGTCGGATAG","4.70","-23.81","63086","MVYQENYQKWLAYAKLPDYLHQELLAMDEKTKEDAFYTNLEFGTAGMRGYIGAGTNRINIYVVRQATEGLAQLIETKGDDVKKRGVAIAYDSRHFSQEFAFESAQVLAKHGIKAYVFESLRPTPELSFTVRHLGTFAGIMVTASHNPAPFNGYKVYGEDGGQMPPFDADALTDFIRAINDPFSIELADLEESKASGLIEVIGEAVDTDYLKEVKDVNINQKLIDEYGKDMKIVYTPLHGTGEMLARRALAQAGFDSVQVVEAQAVPDPDFSTVKSPNPENQEAFRLAEELGRQVDADVLVATDPDADRLGVEIRQADGSYKNLSGNQIGAIIAKYILEAHKTAGSLPTNAALCKSIVSTELVSKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMFGFEESFGYLIKPFVRDKDAIQAVLIVAEIAAYYRSRGLTLADGIDEIYKEYGYFAEKTISVTLSGVDGATEIKKIMDKFRGDAPKQFNATDVVKLEDFQAQTATTADGIEKLTTPPSNVLKYILSDASWIAVRPSGTEPKIKFYIATVGNNSEDAQVKIANIEKEINDFVG","1021525","","phosphoglucomutase","Cytoplasm","Several matches in gapped BLAST to phosphoglucomutase: residues 1-571 are 85% similar to the enzyme in S.thermophilus (gi|8920345|) and are 83% similar to the protein from S.pyogenes(gi|15675188|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1066 (0.0).","

InterPro
IPR005841
Family

Phosphoglucomutase/phosphomannomutase
PR00509	$\"[137-151]T$ $\"[296-311]T$	PGMPMM
PS00710	$\"[138-147]T$	PGM_PMM

InterPro
IPR005843
Domain

Phosphoglucomutase/phosphomannomutase C-terminal
PF00408	$\"[495-564]T$	PGM_PMM_IV

InterPro
IPR005844
Domain

Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I
PF02878	$\"[39-182]T$	PGM_PMM_I

InterPro
IPR005845
Domain

Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II
PF02879	$\"[207-322]T$	PGM_PMM_II

InterPro
IPR005846
Domain

Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III
PF02880	$\"[324-447]T$	PGM_PMM_III

noIPR
unintegrated

unintegrated
G3DSA:3.40.120.10	$\"[22-210]T$ $\"[322-456]T$	G3DSA:3.40.120.10
PTHR22573	$\"[103-567]T$	PTHR22573
PTHR22573:SF2	$\"[103-567]T$	PTHR22573:SF2
SSF55957	$\"[456-571]T$	SSF55957

","BeTs to 17 clades of COG1109COG name: PhosphomannomutaseFunctional Class: GThe phylogenetic pattern of COG1109 is aMTKYQVCEBRHUJgpOLINxNumber of proteins in this genome belonging to this COG is 2","***** IPB001485 (Phosphoglucomutase and phosphomannomutase family) with a combined E-value of 3.3e-06. IPB001485 138-147","Residues 156-197 are 80% similar to a (CPS3M PHOSPHOGLUCOMUTASE ISOMERASE PGM) protein domain (PD330119) which is seen in Q9K560_STRTR.Residues 33-78 are 91% similar to a (PROTEOME PHOSPHOMANNOMUTASE COMPLETE) protein domain (PD344043) which is seen in Q9RP94_STRPN.Residues 73-155 are 85% similar to a (PHOSPHOMANNOMUTASE PHOSPHOGLUCOMUTASE ISOMERASE COMPLETE) protein domain (PD000667) which is seen in P72553_STRPN.Residues 513-554 are 83% similar to a (PHOSPHOMANNOMUTASE PROTEOME COMPLETE) protein domain (PD006924) which is seen in Q9K560_STRTR.Residues 298-422 are 42% similar to a (PHOSPHOMANNOMUTASE PHOSPHORYLATION) protein domain (PD358212) which is seen in O51775_BORBU.Residues 276-418 are 29% similar to a (PHOSPHOMANNOMUTASE COMPLETE PROTEOME ISOMERASE) protein domain (PD000778) which is seen in Q9KUB2_VIBCH.Residues 198-286 are 86% similar to a (COMPLETE PROTEOME PHOSPHOMANNOMUTASE) protein domain (PD343822) which is seen in Q9RP94_STRPN.Residues 179-283 are 32% similar to a (PMMLP 4931406N15RIK PHOSPHOMANNOMUTASES) protein domain (PD235454) which is seen in Q9D4L5_MOUSE.Residues 422-494 are 86% similar to a (PHOSPHOMANNOMUTASE PROTEOME COMPLETE) protein domain (PD395118) which is seen in Q9K560_STRTR.Residues 181-289 are 29% similar to a (PHOSPHOMANNOMUTASE PHOSPHORYLATION) protein domain (PD348536) which is seen in MANB_MYCPI.Residues 292-420 are 89% similar to a (PHOSPHOGLUCOMUTASE COMPLETE PROTEOME ISOMERASE) protein domain (PD344757) which is seen in Q9RP94_STRPN.Residues 12-121 are 40% similar to a (PROTEOME PHOSPHOMANNOMUTASE COMPLETE CPSG) protein domain (PD097474) which is seen in O51775_BORBU.Residues 1-32 are 68% similar to a (CPS3M PHOSPHOGLUCOMUTASE ISOMERASE PGM) protein domain (PD034987) which is seen in Q9RP94_STRPN.Residues 178-281 are 34% similar to a (PHOSPHORYLATION PHOSPHOMANNOMUTASE) protein domain (PD241121) which is seen in Q9CLX5_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 30 16:15:05 2002","Wed Jan 30 16:15:05 2002","Tue Oct 15 12:05:57 2002","Wed Jan 30 16:13:56 2002","Wed Jan 30 16:13:56 2002","Wed Jan 30 16:13:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0985 is paralogously related (blast p-value < 1e-3) to SMu1301, a predicted phospho-sugar mutase.","Wed Jan 30 16:17:15 2002","Wed Jan 30 16:13:56 2002","pdb|3PMG|A Chain A, Phosphoglucomutase Mol_id: 1; Molecule: Alp... 69 1e-012pdb|1JDY|A Chain A, Rabbit Muscle Phosphoglucomutase >gi|194219... 68 3e-012","SMU.1077","","Residues 39 to 182 (E-value = 1.2e-53) place SMu0985 in the PGM_PMM_I family which is described as Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I (PF02878)","Wed Jan 30 16:13:56 2002","24379514","","","Levander,F. and Radstrom,P.Requirement for Phosphoglucomutase in ExopolysaccharideBiosynthesis in Glucose- and Lactose-Utilizing StreptococcusthermophilusAppl. Environ. Microbiol. 67 (6), 2734-2738 (2001)PubMed: 11375188Hardy,G.G., Caimano,M.J. and Yother,J.Capsule biosynthesis and basic metabolism in Streptococcuspneumoniae are linked through the cellular phosphoglucomutaseJ. Bacteriol. 182 (7), 1854-1863 (2000)PubMed: 10714989","","Wed Jan 30 16:16:02 2002","1","","","SMU.1077","121" "SMu0986","1023393","1021648","1746","ATGAAAGCTAGAAATAATAAAAATACCTTAAAGCGCTTGACTGCTGACTTTCTTAAGCAGAGAATTTTGGTTTTTCTTGCCTTATTGGGTACTTTGATTCAGGTCAGCCTAACGGTTTATCTCCCAGTTCTAATTGGGCGAGCAGTTGATGCTGTTCTTGCTAAAAATGTCCAGAAAATCTTACCGACAATCTTGATTAGCATGATTCTTGTTGTTGCCTTTAATACCATTATCCAATGGATTAATCCCTTGATTTACAATCGTTTGGTTTTCACTTATAGCCAGGAGCTTCGGCAGAATATCATTGAAAAACTTTATCGCCTCCCTTTATCTTATTTGGATAAGCATTCTTCAGGTGATTTAGTCAGTCGTATAACAACGGATGTTGAACAATTATCCAACGGACTTTTGATGGTTTTTAATCAGTTTTTCGTAGGTATTTTGACTATTTTGTTAACCATCATAACAATGGCGAAGCTAGACTTTTTTATGATGGTTTTGGTACTGGCCTTAACACCACTTTCCTTATTTGTTGCTCGTTTTATTGCTCAAAGGAGTTATCATCTTTATCAAAGACAAACCAGAGCCAGAGGGGCGTTTACTCAACATATTGAAGAGAGTCTTCGTCAGGAAAGTTTGATTCAAAGTTTCAATGCTCAAGATCAATTTATTCACACTTTTGATCATCTAAATAGCAAATATGCTAAGTATTCACAAGGGGCTATTTTCTATTCATCCACAGTCAACCCTGCGACTCGTTTTATCAATGCCTTAATTTATGCGCTCTTAGCTGGTATCGGAGCATTACGCATTATGAATGGGAATTTTACTGTGGGGCAATTGACCACTTTCTTGAATTATGTCATTCAATATACCAAACCCTTCAATGACATTTCAGCCGTTCTATCTGAATTACAAAGTGCTTTAGCATGTGCAGAACGTCTTTATATGATTCTCGATGAAAGAGATGCTAAGGATGATGGCAAGAAAGAATTAGTCAGTGAATCTGTTAAAGGTGCTATTACCTTTGATAAGATTAGTTTTGGTTATGATGAGAAACAAACTCTGATTAAGAATTTGTCTGTCAATATTCCACAAGGTTCCAAAGTGGCTATCGTTGGTCCTACAGGGGCTGGAAAATCAACTCTCATTAATTTGCTGATGCGATTTTATGATTTGCGAGAAGGGCAAATACTGCTAGATGGGCAAGCAATCACTGACTATAGTAAAGCTTCTTATCGTCAGCAGATTGGTATGGTCTTACAAGAAACTTGGCTGAAAACGGCTACTGTTTTGGAAAATATTGCCTTTGGTTATCCTGAAGCTAGCCGCGAGCAAGTGATTGCAGCGGCAAAAGCAGCTAATGCCGACTTTTTTATAAAACAACTTCCTCAAGGTTACGATACTTTTTTGGCCGATGCAGGAGAATCCCTATCACAAGGGCAAAGGCAATTGTTAACGATAGCACGAATTTTTGTTCATATTCCTAAAATATTAATCTTGGATGAAGCAACTTCCTCCATTGATACACGAACAGAAATCTTGGTCCAAGAAGCATTTGAAAAGCTTATGAAAGGACGGACCAGCTTTATTATTGCACATAGATTGTCAACTATTCAAAGCGCAGACCTTATCTTAGTTATGGTAGATGGCAATATTGTTGAACAAGGAAATCATAAAGACTTGATGCAGAAAAAAGGTGTCTATTATCAAATGCAGACAGCACAGGATAGCCTTGAAAGCTAA","9.90","8.90","65361","MKARNNKNTLKRLTADFLKQRILVFLALLGTLIQVSLTVYLPVLIGRAVDAVLAKNVQKILPTILISMILVVAFNTIIQWINPLIYNRLVFTYSQELRQNIIEKLYRLPLSYLDKHSSGDLVSRITTDVEQLSNGLLMVFNQFFVGILTILLTIITMAKLDFFMMVLVLALTPLSLFVARFIAQRSYHLYQRQTRARGAFTQHIEESLRQESLIQSFNAQDQFIHTFDHLNSKYAKYSQGAIFYSSTVNPATRFINALIYALLAGIGALRIMNGNFTVGQLTTFLNYVIQYTKPFNDISAVLSELQSALACAERLYMILDERDAKDDGKKELVSESVKGAITFDKISFGYDEKQTLIKNLSVNIPQGSKVAIVGPTGAGKSTLINLLMRFYDLREGQILLDGQAITDYSKASYRQQIGMVLQETWLKTATVLENIAFGYPEASREQVIAAAKAANADFFIKQLPQGYDTFLADAGESLSQGQRQLLTIARIFVHIPKILILDEATSSIDTRTEILVQEAFEKLMKGRTSFIIAHRLSTIQSADLILVMVDGNIVEQGNHKDLMQKKGVYYQMQTAQDSLES","1021662","For other components see SMu0986 (NBD1); SMu0987 (NBD2) and SMu0987 (MSD2).","multidrug ABC transporter, ATP-binding and permease protein","Membrane, Cytoplasm","Matches in gapped BLAST to Mut:residues 19-550 are 22% similar to the previously published protein in S.mutans (gi5918764). Residues 1-575 are 60% similar to ABC transporter, ATP-binding / permease protein from S.pneumoniae (gi15901211).Residues 4-573 are 53% similar to the protein from S.pyogenes (gi15675126). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1070 (0.0).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[24-295]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[478-519]T$	ABC_transporter
PF00005	$\"[367-551]T$	ABC_tran
PS00211	$\"[478-492]?$	ABC_TRANSPORTER_1
PS50893	$\"[341-575]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[366-558]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[25-307]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[306-576]T$	G3DSA:3.40.50.300
PTHR19242	$\"[2-576]T$	PTHR19242
PTHR19242:SF91	$\"[2-576]T$	PTHR19242:SF91
SSF52540	$\"[341-580]T$	SSF52540
SSF90123	$\"[5-323]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.9e-65. IPB001140A 356-402 IPB001140B 475-513 IPB001140C 528-557","Residues 523-555 are 78% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383) which is seen in Q9EW97_BBBBB.Residues 3-249 are 20% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD320911) which is seen in Q9X151_THEMA.Residues 25-225 are 20% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD353690) which is seen in Q9KRY4_VIBCH.Residues 37-143 are 29% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348) which is seen in Q9KDT6_BACHD.Residues 272-351 are 36% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in Q9KEN7_BACHD.Residues 357-405 are 69% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9ZIA7_BRUAB.Residues 477-519 are 74% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CIU3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:25:35 2005","Thu Aug 3 11:20:12 2006","Tue May 3 12:25:35 2005","Wed Jan 30 16:34:32 2002","Wed Jan 30 16:34:32 2002","Wed Jan 30 16:34:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0986 is paralogously related (blast p-value < 1e-3) to SMu0825, SMu0837, SMu0476, SMu0475, SMu0824, SMu1710, SMu1064, SMu0258, SMu1065, SMu0836, SMu0987, SMu1724, SMu1950, SMu1316, SMu0024, SMu1762, SMu1949, SMu0517, SMu1380, SMu1246, SMu1231, SMu1003, SMu0884, SMu0731, SMu0907, SMu1288, SMu1210, SMu1920, SMu1410, SMu1757, SMu1036, SMu0218, SMu1068, SMu0971, SMu1037, SMu0418, SMu0805, SMu0390, SMu0235, SMu0916, SMu0849, SMu0786, SMu1079, SMu1545, SMu1428, SMu1518, SMu0976, SMu0335, SMu1023, SMu0594, SMu0374, SMu1751, SMu0596, SMu0224, SMu1517, SMu1649, SMu0164, SMu0216, SMu1001, SMu0823, SMu0950, SMu0234, SMu1811, SMu1093, SMu0666, SMu1306, SMu0944, SMu0752, SMu0729, SMu1050, SMu1959, and SMu1202 all with ATP binding capabilities.","Wed Jan 30 16:36:49 2002","Tue May 3 12:25:35 2005","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 73 1e-013","SMU.1078c","","Residues 24 to 295 (E-value = 1.1e-36) place SMu0986 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 367 to 551 (E-value = 1.9e-58) place SMu0986 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue May 3 12:25:35 2005","24379515","","Qi,F., Chen,P. and Caufield,P.W.Purification of mutacin III from group III streptococcus mutansUA787 and genetic analyses of mutacin III biosynthesis genesAppl. Environ. Microbiol. 65 (9), 3880-3887 (1999)PubMed: 10473390Qi,F., Chen,P. and Caufield,P.W.Purification and Biochemical Characterization of Mutacin I from the Group I Strain of Streptococcus mutans, CH43, and Genetic Analysis of Mutacin I Biosynthesis GenesAppl. Environ. Microbiol. 66 (8), 3221-3229 (2000)Pubmed:10919773","","Thu Jan 31 08:35:30 2002","","1","","","SMU.1078c","122" "SMu0987","1025123","1023390","1734","ATGAAATCATTACTTATCTATTTTAAGGGGTATCTCAAAGAAACCATACTTGGCCCCGTCTTCAAACTTTTAGAGGCCTCTTTTGAATTGCTAGTTCCCTTGGTTATTGCCAAAATGGTTGATCGTTATATTCCTCATAATGATAAAAATCATCTTTATTTGATGATTTTCTTTCTGGTTTTATTAGCTTGTTCCAATATTACGGTGGCTCTTATTGCCCAATATTGTTCTGCTAAAGCAGCAGTGGGCTATACTAAACAGCTTAGTCAAAGTCTTTTTCAAAAAATCATGCGCTTGCCCAAGGAAAAACGCGATGAATTGACAACGTCAAGTTTAGTGACACGTTTGGTTAGTGATACCTTTCAAATTCAAACTGGCATTAATCAATTCTTGCGCCTTTTTCTTAGAGCACCAATTATTGTTTTTGGTTCAGTCTTGATGGCTTTTTTAATTAGTCCCAGAATTACCATTTGGTTTTTCCTGATGATTTTTGTCCTTTTTGCTTTAGTTTATCTCATGTCTGTTGTGGTCAATCCTCTCTATGATAAGATTCGCCGTCTAACTGATAAAATTGTTGGTTTAACTCGTGAACAATTAGAAGGAAGTCGTGTTATTCGTGCTTTTGGTCAAATAAAAGCAGAAGAGGAGAATTTTCAAAAAACGAATCAAGATTATACGGATTGGCAAATTAAAACAGGTTATATTTCAACCTTAATAACCCCTCTGACCTATTTAGCTGTCAATGTCACCTTGATTGTTGTCATTTGGCAGGGACAAATTGCTATTTCACATCATTATTTGAGTCAGGGAATACTAATTGCACTAGTCAATTATTTGCTGCAAATTCTGGTAGAGCTTTTAAAATTAACGATGTTGGTTTCTTCTTTGAATCAGAGTTTTATCAGCGCTAGACGAATCACTCAGGTTTTTGACCAAGAGGAAGAAGATGTTTTAGCGCCTTTGCAATCTCAACTCGTTTCGGATGATGTCCTTGTTAAAGTGACAGATATGACTTTTTCCTATCCTCAGGCTGCTAAATCAGCTCTTGAAAGAATTTCTTTTGCTGTTGGACAAGGAGAATTCTTTGGTATTATTGGCGGGACTGGTTCTGGAAAGTCTAGTTTAATTCAAGTTCTGTTGCGTCTTTATCTCCCTCAAAAGGGCAATGTCGCTATTTTTAAGGACAAAAGGAGTGCAAAAACCATCAAGGAATGGCGAAATTGGGTTAGTCTGGTTCCTCAAAAGGCAGAACTCTTCACAGGAACGATTCGTTCTAACTTGTTGCTTAGTACAGAAAAACAAGTCAGTGATGAGCAGCTTTGGCAAGTGCTTGATATAGCTCAGGCTAGCGATTTTGTTAATCAGAAGCCAGGAAAACTTGATGCCCAAGTAGAAGCCTTTGGAAGGAATTTTTCAGGCGGACAGAGACAGCGTTTGACTATTGCTAGAGCTTTATTAAAAGAAGCACCTTTGCTGATACTAGATGACGCCACTTCAGCTCTTGATTATTTAACAGAAGCAAAACTCTTACAGGCTATCAAGGATAATTTTAAGAAGACGACACTTATTATGGTATCTCAAAGGACTAACAGTCTTTCTAAGGCAGATAATATTTTGGTTTTGGATCAAGGAAAGCAAGTGGCATTAGCCGATCATGCTAAGCTTTTACAAACCTGTTCGCTTTATCAGGAAATTCATTACTCGCAACATCCGCAAGAGGAGGTTGTCAAATGA","10.00","12.57","65220","MKSLLIYFKGYLKETILGPVFKLLEASFELLVPLVIAKMVDRYIPHNDKNHLYLMIFFLVLLACSNITVALIAQYCSAKAAVGYTKQLSQSLFQKIMRLPKEKRDELTTSSLVTRLVSDTFQIQTGINQFLRLFLRAPIIVFGSVLMAFLISPRITIWFFLMIFVLFALVYLMSVVVNPLYDKIRRLTDKIVGLTREQLEGSRVIRAFGQIKAEEENFQKTNQDYTDWQIKTGYISTLITPLTYLAVNVTLIVVIWQGQIAISHHYLSQGILIALVNYLLQILVELLKLTMLVSSLNQSFISARRITQVFDQEEEDVLAPLQSQLVSDDVLVKVTDMTFSYPQAAKSALERISFAVGQGEFFGIIGGTGSGKSSLIQVLLRLYLPQKGNVAIFKDKRSAKTIKEWRNWVSLVPQKAELFTGTIRSNLLLSTEKQVSDEQLWQVLDIAQASDFVNQKPGKLDAQVEAFGRNFSGGQRQRLTIARALLKEAPLLILDDATSALDYLTEAKLLQAIKDNFKKTTLIMVSQRTNSLSKADNILVLDQGKQVALADHAKLLQTCSLYQEIHYSQHPQEEVVK","1023404","For other components see SMu0986 (NBD1 and MSD1) and SMu0987 (MSD2).","ABC transporter, ATP-binding / permease protein","Membrane, Cytoplasm","Matches in gapped BLAST to ABC transporter,MutT:residues 1-450 are 96% similar to the previously published protein in S.mutans(gi4587160). Residues 1-574 are 55% similar to ABC transporter, ATP-binding / permease protein from S.pneumoniae (gi15901212).Residues 1-565 49% similar to the protein in S.pyogenes (gi15675125).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1071 (0.0).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[15-286]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[470-513]T$	ABC_transporter
PF00005	$\"[359-544]T$	ABC_tran
PS00211	$\"[471-485]T$	ABC_TRANSPORTER_1
PS50893	$\"[332-568]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[358-545]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[16-298]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[297-570]T$	G3DSA:3.40.50.300
PTHR19242	$\"[1-575]T$	PTHR19242
PTHR19242:SF91	$\"[1-575]T$	PTHR19242:SF91
SSF52540	$\"[331-573]T$	SSF52540
SSF90123	$\"[2-320]T$	SSF90123

noIPR
unintegrated

unintegrated
PTHR21666	$\"[85-148]T$	PTHR21666
PTHR21666:SF9	$\"[85-148]T$	PTHR21666:SF9
SSF53955	$\"[32-149]T$	SSF53955

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 31-189 are 53% similar to a (PROTEOME COMPLETE PLASMID ORF14) protein domain (PD023142) which is seen in Q9CHW6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 10:31:07 2002","Mon Feb 4 10:31:07 2002","Mon Feb 4 10:31:07 2002","Thu Jan 31 09:05:22 2002","","Thu Jan 31 09:05:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0988 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Jan 31 09:05:22 2002","","No significant hits to the NCBI PDB database.","SMU.1080c","","No significant hits to the Pfam 11.0 database","Thu Jan 31 09:05:22 2002","24379517","","","","","","1","","","SMU.1080c","680" "SMu0989","1026726","1025749","978","ATGATGGATTTGTATTTAAAAAAGATTGTCATTCACCAATTTACTCCAGATGATACTGAGCTCATTCTTTCGGATAAATGCTTAACTATTACACCCAATTTAGATACTTATTTTCGAAAAAAAGTAGGTAAAGTTTTTTCTGACGAAGCTAGGCGTGGTCAGTTTGATAGTGGTAATGTCTTTCTTAGTTATTTGACAGATGACTTTTTAGAGTCCTCCAAGAAAATTGCCCACCTTTGGAAAGAAGAATTCGTTATCAGTGACAATCAAAAAACGAATGATTTAGTTTTTCTTCAGTTTGATAAAGAGGGCATTGAGCATTTTGCTTTCTTAAGACTAGCTCTAAAGGAGAGTTTAACGCATATTATTGATGGTGGCGATAGCCCCCTGCGCCTGACACAAAATAATTTGCCGTCTGCTGCACAAACACCAGATGAAGCTTTGATTATCAATCGTCAAAATCAGCAGTATTATCTTATTGAAAAGCGCATTAAGCATAATGGCTCTTTTGCTAATTATTTTTCAGAGAATCTTCTTCAAGTTAAGCCTGAACAATCGGTTAAAAAGTCCATTAAGATGATGGAACAGACAGCACAAAAAATTGCTGATAATTTCAATCAAGATGACTTTGCTTTTCATGCAAAGATGAAAACCGCCATTTATAAAAATTTGGAAGAAGATCAGGAATTATCACCAGAAAAATTAGCCGATCAGCTCTTTGATTCTAATCTGACAGCGCGTTTAAATTTTATTGATGACTTGAAAGAAACAATCCCAGAGTCAATCAAAGTTTCTGATATCGATCATTCTCGTCAAACTAAAAAATTGGAGAATCAAAAACTGTCTCTTTCCAATGGAATTGAGCTTTTAGTGCCCAATCATATCTATCAGGATGCAGAATCTGTTGAATTTATCCAAAACCAAAATGGAACTTATTCTATTTTGATCAAAAATATCGAAGACATACAAAGTAAATAA","5.10","-10.09","37550","MMDLYLKKIVIHQFTPDDTELILSDKCLTITPNLDTYFRKKVGKVFSDEARRGQFDSGNVFLSYLTDDFLESSKKIAHLWKEEFVISDNQKTNDLVFLQFDKEGIEHFAFLRLALKESLTHIIDGGDSPLRLTQNNLPSAAQTPDEALIINRQNQQYYLIEKRIKHNGSFANYFSENLLQVKPEQSVKKSIKMMEQTAQKIADNFNQDDFAFHAKMKTAIYKNLEEDQELSPEKLADQLFDSNLTARLNFIDDLKETIPESIKVSDIDHSRQTKKLENQKLSLSNGIELLVPNHIYQDAESVEFIQNQNGTYSILIKNIEDIQSK","1025763","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 1-325 are 70% similar to S.pyogenes (gi|15675123|) and residues 2-325 are 65% similar to S.pneumoniae (gi|15902973|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1073 (1e-145).","

InterPro
IPR013212
Domain

Mad3/BUB1 homology region 1
SM00777	$\"[112-198]T$	no description

InterPro
IPR001085
Family

Glycine hydroxymethyltransferase
PIRSF000412	$\"[6-418]T$	SHMT
PTHR11680	$\"[10-420]T$	Gly_HO-Metrfase
PF00464	$\"[8-386]T$	SHMT
PS00096	$\"[222-238]T$	SHMT

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[37-288]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[6-416]T$	PyrdxlP-dep_Trfase_major

","BeTs to 17 clades of COG0112COG name: Glycine hydroxymethyltransferaseFunctional Class: EThe phylogenetic pattern of COG0112 is amtkYqvcebRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001085 (Serine hydroxymethyltransferase (SHMT)) with a combined E-value of 6.5e-157. IPB001085A 37-86 IPB001085B 101-130 IPB001085C 183-233 IPB001085D 250-286 IPB001085E 330-352 IPB001085F 359-383","Residues 11-386 are 71% similar to a (SERINE HYDROXYMETHYLTRANSFERASE SHMT) protein domain (PD001547) which is seen in GLYA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 11:04:38 2002","Mon Feb 4 10:53:13 2002","Tue Oct 15 12:10:17 2002","Mon Feb 4 10:52:38 2002","Mon Feb 4 10:52:38 2002","Mon Feb 4 10:52:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0990 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 4 10:52:38 2002","Mon Feb 4 10:52:38 2002","pdb|1DFO|B Chain B, Crystal Structure At 2.4 Angstrom Resolutio... 474 6e-135pdb|1EQB|B Chain B, X-Ray Crystal Structure At 2.7 Angstroms Re... 473 2e-134pdb|1CJ0|A Chain A, Crystal Structure Of Rabbit Cytosolic Serin... 329 3e-091","SMU.1082c","","Residues 8 to 386 (E-value = 2.5e-237) place SMu0990 in the SHMT family which is described as Serine hydroxymethyltransferase (PF00464)","Mon Feb 4 10:52:38 2002","","","","Steiert,J.G., Urbanowski,M.L., Stauffer,L.T., Plamann,M.D. andStauffer,G.V.Nucleotide sequence of the Salmonella typhimurium glyA geneDNA Seq. 1 (2), 107-113 (1990)PubMed: 2134182Urbanowski,M.L., Plamann,M.D., Stauffer,L.T. and Stauffer,G.V.Cloning and characterization of the gene for Salmonella typhimurium serine hydroxymethyltransferaseGene 27 (1), 47-54 (1984)PubMed: 6325301","","Mon Feb 4 11:04:14 2002","1","","","SMU.1082c","124" "SMu0991","1028585","1027995","591","ATGGATAAAATTGAAGAAGCACTTAGAGAGGGACAGGCAGTTGTTCTGCCAACAGAAACCGTCTATGGTCTTTTTGCTCAAGCTTTGAGCAAAAGAGCTGTTGATAATGTTTATGATTTAAAAAAACGGCCACGCGAAAAAGCAATGAACTTAAACGTTGCCTCTTTAGAAGATATTTTGGCTTTTTCAAAAGAGGCACCAGCTTATTTGGCAGAACTCTATAAAGCTTTTTTACCGGGTCCCTTAACCATTGTCTTGAAAGCTAACGAAAAAGTGCCAGCTTGGATTAATGGCGGTTTATCAACTGTTGGTTTCAGGGTCCCCGCCCACCCTCAAACTCTAGCCTATATCAAACAGACTGGTCCTTTAATTGGTCCTTCTGCTAATTTATCTGGACAGGCAAGTGGTTTGGTTTATCGGGAAATTCAAGAGGCTTTTGCTAATCGTTTATTAGGTATTCAGGATGATAAGGCAATAAAAGGAAGAGACTCGACTATTTTAGATATTTCAAGTTCACGAGCAAAGATTCTGAGACAAGGAGCGCTTACACAGGACGCTATTCAAGCGCATGTGAAAAATATAAGATTTTAA","10.20","5.48","21383","MDKIEEALREGQAVVLPTETVYGLFAQALSKRAVDNVYDLKKRPREKAMNLNVASLEDILAFSKEAPAYLAELYKAFLPGPLTIVLKANEKVPAWINGGLSTVGFRVPAHPQTLAYIKQTGPLIGPSANLSGQASGLVYREIQEAFANRLLGIQDDKAIKGRDSTILDISSSRAKILRQGALTQDAIQAHVKNIRF","1028009","","conserved hypothetical protein","Cytoplasm, Periplasm","Several matches in gapped BLAST to conserved hypothetical protein and to several other proteins:residues 1-196 are 62% similar to S.pyogenes (gi|15675120|) and 58% similar to S.pneumoniae (gi|15902970|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1075 (6e-62).","

InterPro
IPR004388
Domain

Sua5/YciO/YrdC/YwlC
TIGR00057	$\"[2-192]T$	Sua5_YciO_YrdC

InterPro
IPR006070
Domain

SUA5/yciO/yrdC, N-terminal
PF01300	$\"[6-180]T$	Sua5_yciO_yrdC
PS51163	$\"[1-182]T$	YRDC

InterPro
IPR012200
Family

RNA-binding protein, YrdC
PIRSF004931	$\"[1-190]T$	RNA-binding_YrdC

noIPR
unintegrated

unintegrated
G3DSA:3.90.870.10	$\"[1-195]T$	G3DSA:3.90.870.10
PTHR17490	$\"[11-189]T$	PTHR17490
SSF55821	$\"[1-188]T$	SSF55821

","BeTs to 15 clades of COG0009COG name: Putative translation factor (SUA5)Functional Class: JThe phylogenetic pattern of COG0009 is amtkyqvCEbrH----olinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000666 (SUA5/yciO/yrdC family) with a combined E-value of 2.4e-11. IPB000666A 13-41 IPB000666B 163-180 IPB000666B 81-98","Residues 12-180 are 32% similar to a (PROTEOME COMPLETE) protein domain (PD103089) which is seen in P74144_SYNY3.Residues 87-180 are 36% similar to a (5 PROTEOME FLJ23476 FIS) protein domain (PD404671) which is seen in Q9WZV6_THEMA.Residues 6-85 are 55% similar to a (PROTEOME COMPLETE SUA5 RELATED) protein domain (PD413069) which is seen in Q9CHW8_LACLA.Residues 86-194 are 42% similar to a (PROTEOME YFJA COMPLETE) protein domain (PD395635) which is seen in Q9CHW8_LACLA.Residues 8-85 are 43% similar to a (PROTEOME COMPLETE PA0022 III) protein domain (PD337688) which is seen in O73972_PYRHO.Residues 86-188 are 33% similar to a (PROTEOME COMPLETE SUA5 RELATED) protein domain (PD375788) which is seen in Q9UX54_SULSO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 11:08:56 2002","Mon Feb 4 11:08:56 2002","Mon Feb 4 11:08:56 2002","Mon Feb 4 11:08:56 2002","Mon Feb 4 11:08:56 2002","Mon Feb 4 11:08:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0991 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 4 11:08:56 2002","Mon Feb 4 11:08:56 2002","pdb|1HRU|A Chain A, The Structure Of The Yrdc Gene Product From... 71 1e-013","SMU.1083c","","Residues 6 to 180 (E-value = 2.4e-38) place SMu0991 in the Sua5_yciO_yrdC family which is described as yrdC domain (PF01300)","Mon Feb 4 11:08:56 2002","24379520","","","","","","1","","","SMU.1083c","681" "SMu0992","1029414","1028578","837","ATGATGAATTATGGACAAGTTTTTGCCCAATATGAATCAGAACTTGAAGCTTTGGGAGAAGAAAAGGAAAGTTTGGCCTACGTTTTTAAAGATTGTAAGGGTTGGAATCAGACAGATTTTATCCTTCAACAGCCACAAGAAATTGCTGAAGCGGATCTGACTAAACTTGAAGAAATCATGCAACAATTAAGGCAGCATATCCCTGCTCAATATATCACAGGAAAAGCTTACTTTGCTGACTTAATCCTATCAGTTGATGAACGTGTTTTGATTCCAAGGCCAGAAACAGAAGAATTAGTCAAACTTATCTTAAAAGAAAATCAGCATAGAAGCTCTGCTAAACTTTTAGACATTGGTACAGGCAGCGGTGCTATTGCTTTGGCTCTTGCAAAAGCTCAGCCAGATTGGCAAGTATGGGCTAGCGATATTTCAGAAGATGCTCTTAATTTAGCACAGGAAAACGCTACTGTTAATCAAGCAGCTGTGACCTTTTTGCAGTCAGATATTTTTAGTCACATTTCAGATAAATACGATATTATTGTTTCTAACCCACCTTATATTTCTTTAAGGGATCAAGATGAAGTTGAACAGAATGTTTTGGCACACGAACCCCATTTAGCGCTTTTTGCTGATAATGATGGCTTAGCTTTCTATCAGAAGTTAGCTTTAGAAGCTGAGCATTATTTAAAACTTACAGGTAAAATTTACTTAGAAATTGGCTACAAGCAGGGAGAAGCAGTTTCTCAGCTTTTTGAAAGACAGTTCCCAAATAAGCGTGTTCGCCTTTTGCAGGATAGTTTTGGCAAGGATAGAATGGTTGTGGTTGACGATGGATAA","4.50","-18.58","31508","MMNYGQVFAQYESELEALGEEKESLAYVFKDCKGWNQTDFILQQPQEIAEADLTKLEEIMQQLRQHIPAQYITGKAYFADLILSVDERVLIPRPETEELVKLILKENQHRSSAKLLDIGTGSGAIALALAKAQPDWQVWASDISEDALNLAQENATVNQAAVTFLQSDIFSHISDKYDIIVSNPPYISLRDQDEVEQNVLAHEPHLALFADNDGLAFYQKLALEAEHYLKLTGKIYLEIGYKQGEAVSQLFERQFPNKRVRLLQDSFGKDRMVVVDDG","1028592","For other 'hem' genes see SMu1293 (hemN) and SMu1872 (hemZ). ","protoporphyrinogen oxidase","Cytoplasm","Several matches in gapped BLAST to HemK protein: residues 2-278are 55% similar to the protein in S.pneumoniae (gi|15900892|) and are 51% similar to the protein from S.pyogenes (gi|15675119|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1076 (3e-84).","

InterPro
IPR002052
Domain

N-6 Adenine-specific DNA methylase
PS00092	$\"[180-186]?$	N6_MTASE

InterPro
IPR004556
Family

Modification methylase HemK
TIGR00536	$\"[2-278]T$	hemK_fam

InterPro
IPR013216
Domain

Methyltransferase type 11
PF08241	$\"[116-183]T$	Methyltransf_11

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[76-274]T$	G3DSA:3.40.50.150
PTHR18895	$\"[94-274]T$	PTHR18895
PTHR18895:SF7	$\"[94-274]T$	PTHR18895:SF7
SSF53335	$\"[2-275]T$	SSF53335

","BeTs to 17 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","***** IPB000339 (ubiE/COQ5 methyltransferase family) with a combined E-value of 8.4e-06. IPB000339B 114-128 IPB000339C 137-154","Residues 177-275 are 56% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME METHYLASE HOMOLOG) protein domain (PD005237) which is seen in Q9CHX0_LACLA.Residues 115-186 are 40% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD015912) which is seen in Y928_METJA.Residues 106-169 are 60% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME ARGININE) protein domain (PD006760) which is seen in Q9CHX0_LACLA.Residues 107-273 are 32% similar to a (MAS5-GCD10) protein domain (PD303653) which is seen in YNG3_YEAST.Residues 177-240 are 40% similar to a (PROTEOME COMPLETE METHYLTRANSFERASE) protein domain (PD288544) which is seen in Q9KQ83_VIBCH.Residues 115-170 are 50% similar to a (TRANSFERASE PROTEOME COMPLETE METHYL) protein domain (PD189938) which is seen in HEMK_BUCAI.Residues 27-104 are 46% similar to a (COMPLETE PROTEOME METHYLTRANSFERASE) protein domain (PD001640) which is seen in Q9CHX0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 12:11:08 2002","Mon Feb 4 11:17:15 2002","Tue Oct 15 12:11:08 2002","Mon Feb 4 11:15:48 2002","Mon Feb 4 11:15:48 2002","Mon Feb 4 11:15:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0992 is paralogously related (blast p-value < 1e-3) to SMu1028, a predicted conserved hypothetical protein and SMu1861,a predicted ribosomal protein L11 methylase.","Mon Feb 4 11:15:48 2002","","No significant hits to the NCBI PDB database.","SMU.1084c","","No significant hits to the Pfam 11.0 database","Mon Feb 4 11:15:48 2002","","","","Dailey TA, Meissner P, Dailey HA.Expression of a cloned protoporphyrinogen oxidase.J Biol Chem. 1994 Jan 14;269(2):813-5.PMID: 8288631Corrigall AV, Siziba KB, Maneli MH, Shephard EG, Ziman M, Dailey TA, Dailey HA,Kirsch RE, Meissner PN.Purification of and kinetic studies on a cloned protoporphyrinogen oxidase from the aerobic bacterium Bacillus subtilis.Arch Biochem Biophys. 1998 Oct 15;358(2):251-6.PMID: 9784236 ","","Thu Mar 21 10:48:04 2002","1","","","SMU.1084c","562" "SMu0993","1030490","1029411","1080","ATGAATATTTATGATCAACTTCAGGCGGTTGAAGATCGTTATGAAGAATTAGGAGAATTGCTTTCAGATCCAGACGTCGTCAGTGATACCAAGCGTTTTATGGAATTATCGCGAGAAGAAGCCAATAGCCGCGAAACAGTTGCTGTCTATCGTGAGTACAAGCAAGTCGTTCAAAATATTGCTGATGCGCAAGAAATGATTAAAGATGCTAGTGGTGATCCTGAACTTGAGGAAATGGCCAAGGAAGAGTTGAAAAACTCCAAGGTAGCAAAGGAAGAATACGAAGAAAAACTGAGATTTCTCCTTTTACCAAAAGATCCCAACGATGATAAGAATATTATTTTAGAAATTCGTGGTGCTGCAGGCGGTGACGAAGCCGCTCTTTTTGCTGGTGATCTTTTGAATATGTACCAAAAATATGCTGAAAATCAAGGCTGGAAATTTGAGGTGATGGAGGCTTCTGCCAATGGTGTCGGCGGACTCAAGGAAGTCGTTGCTATGGTTTCAGGACAGTCTGTTTATTCTAAACTCAAATATGAATCGGGTGCCCATCGAGTTCAACGTGTTCCTGTAACAGAAAGTCAAGGTCGTGTCCATACCTCAACAGCAACAGTTCTCGTCATGCCCGAAGTTGAAGAAGTCGAATATGAAATAGATCCAAAAGACTTGCGTGTGGATATCTATCATGCTTCAGGTGCTGGTGGGCAAAATGTCAATAAAGTAGCAACTGCGGTTCGTATTATTCATTTGCCAACCAACATTAAAGTTGAAATGCAAGAAGAGCGCACCCAGCAGAAAAATCGTGATAAGGCTATGAAAATTATCCGTGCGCGTGTAGCAGACCACTTTGCGCAAATTGCTCAGGATGAACAAGATGCTGAACGAAAATCAACAGTTGGTACGGGAGACCGTTCAGAGCGTATTCGTACCTATAATTTTCCGCAAAACCGTGTTACAGATCACCGTATTGGGCTGACACTTCAAAAATTAGACAGTATTTTGTCAGGCAAGTTAGATGAAGTCATTGACGCTCTTATTCTTTATGATCAAACACAAAAATTAGAAGAGCTTAATAAATGA","4.80","-17.50","40638","MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANSRETVAVYREYKQVVQNIADAQEMIKDASGDPELEEMAKEELKNSKVAKEEYEEKLRFLLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLNMYQKYAENQGWKFEVMEASANGVGGLKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYEIDPKDLRVDIYHASGAGGQNVNKVATAVRIIHLPTNIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDSILSGKLDEVIDALILYDQTQKLEELNK","1029425","For other 'prf' genes see SMu0554 (prfC) and SMu1211 (prfB).From Genbank:[gi:13487345]:Peptide chain release factor 1 directs the termination of translation in response to termination codons UAG and UAA","peptide chain release factor 1","Cytoplasm","Several matches in gapped BLAST to peptide chain release factor 1: residues 1-358 are 91% similar to the protein in S.pyogenes (gi15675118). Residues 1-359 are 90% similar to the protein from S.pneumoniae (gi15902968).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1077 (0.0).","

InterPro
IPR000352
Domain

Class I peptide chain release factor
PF00472	$\"[209-322]T$	RF-1
PS00745	$\"[229-245]T$	RF_PROK_I

InterPro
IPR004373
Family

Peptide chain release factor 1
PTHR11075:SF9	$\"[3-359]T$	PrfA
TIGR00019	$\"[1-358]T$	prfA

InterPro
IPR005139
Domain

PCRF
PF03462	$\"[65-180]T$	PCRF

InterPro
IPR012086
Family

Protein chain release factor, RF-1/RF-2
PIRSF003056	$\"[4-359]T$	Release_factor

noIPR
unintegrated

unintegrated
PIRSF500105	$\"[3-359]T$	PrfA
PTHR11075	$\"[3-359]T$	PTHR11075
SSF75620	$\"[26-358]T$	SSF75620

","BeTs to 13 clades of COG0216COG name: Protein chain release factor AFunctional Class: JThe phylogenetic pattern of COG0216 is ----YqvcEbrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000352 (Class I peptide chain release factor) with a combined E-value of 9.8e-127. IPB000352A 106-152 IPB000352B 159-210 IPB000352C 222-268 IPB000352D 295-322","Residues 312-347 are 94% similar to a (PEPTIDE FACTOR CHAIN RELEASE) protein domain (PD002191) which is seen in RF1_LACLA.Residues 3-64 are 66% similar to a (RELEASE PEPTIDE FACTOR CHAIN) protein domain (PD004306) which is seen in RF1_LACLA.Residues 182-311 are 55% similar to a (PEPTIDE FACTOR RELEASE CHAIN BIOSYNTHESIS RF-1 RF-2) protein domain (PD002273) which is seen in Q9LYD0_ARATH.Residues 181-209 are 96% similar to a (PEPTIDE RELEASE CHAIN FACTOR) protein domain (PD337042) which is seen in RF1_LACLA.Residues 312-357 are 59% similar to a (PEPTIDE FACTOR CHAIN RELEASE) protein domain (PD346052) which is seen in RF1M_YEAST.Residues 73-180 are 60% similar to a (PEPTIDE FACTOR RELEASE CHAIN) protein domain (PD088320) which is seen in RF1_BACSU.Residues 312-352 are 56% similar to a (RELEASE PEPTIDE FACTOR CHAIN) protein domain (PD402655) which is seen in Q9JT75_NEIMA.Residues 182-214 are 84% similar to a (PEPTIDE FACTOR CHAIN RELEASE) protein domain (PD265533) which is seen in RF1_MYCTU.Residues 7-99 are 31% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in RF1_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 14:47:36 2006","Mon Feb 4 12:53:41 2002","Thu Sep 28 14:47:36 2006","Mon Feb 4 12:53:41 2002","Mon Feb 4 12:53:41 2002","Mon Feb 4 12:53:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0993 is paralogously related (blast p-value < 1e-3) to SMu1211, a predicted peptide chain release factor 2.","Mon Feb 4 12:53:41 2002","","No significant hits to the NCBI PDB database.","SMU.1085c","","Residues 65 to 180 (E-value = 2.5e-64) place SMu0993 in the PCRF family which is described as PCRF domain (PF03462)Residues 211 to 322 (E-value = 1.6e-58) place SMu0993 in the RF-1 family which is described as Peptidyl-tRNA hydrolase domain (PF00472)","Thu Sep 28 14:47:36 2006","","","","Elliott T.Cloning, genetic characterization, and nucleotide sequence of the hemA-prfA operon of Salmonella typhimurium.J Bacteriol. 1989 Jul;171(7):3948-60.PMID: 2544564 ","","Mon Feb 4 12:57:53 2002","1","","","SMU.1085c","125" "SMu0994","1031134","1030550","585","ATGACAGTCTTGGCGCAGTTATATTATAAATATGGGACCATGAATTCAGGTAAGACAATCGAAATTTTAAAGGTTGCTCATAATTATGAAGAACAAGGAAAGCCTGTTGTCATTATGACGAGCAGCTTGGACACGCGAGATGGATTTGGTGTGGTGGCTAGTAGAATTGGCATGCGACGTGAAGCAGTTACTATTACAGATGACATGGATATTTTTGCTTACATCGAAAACATGTTTAAGAAACCTTATTGTATTTTAATTGATGAAAGTCAGTTTTTAAGCCAAAAAAATGTTTATGATCTAGCAAGGATTGTTGATGAATTGGATGTTCCTGTTATGGCCTTTGGGCTCAAAAATGATTTTCAGAACCATCTCTTTGAAGGGTCACGTGAACTCTTGCTGTTAGCTGATAAGATTGAGGAAATTAAAACTATCTGTCAATTTTGCTCCAAAAAGGCAACTATGGTTTTAAGAACAGAAAATGGCAGGCCTGTCTATAAGGGCAATCAAATTCAAATCGGCGGTAATGAAACTTATATTCCTGTCTGTCGAAGACATTACTTCCATCCTCCAATCAAAGCCTGA","7.40","0.77","22216","MTVLAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSSLDTRDGFGVVASRIGMRREAVTITDDMDIFAYIENMFKKPYCILIDESQFLSQKNVYDLARIVDELDVPVMAFGLKNDFQNHLFEGSRELLLLADKIEEIKTICQFCSKKATMVLRTENGRPVYKGNQIQIGGNETYIPVCRRHYFHPPIKA","1030564","","thymidine kinase","Cytoplasm","Several matches in gapped BLAST to thymidine kinase: residues 4-192 are 83% similar to the enzyme in S.pyogenes (gi15675117). Residues 14-192 are 85% similar to the protein from S.agalactiae(gi13249163).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1078 (1e-95).","

InterPro
IPR001267
Family

Thymidine kinase
PTHR11441	$\"[5-188]T$	TK_cell
PF00265	$\"[5-187]T$	TK
PS00603	$\"[174-187]T$	TK_CELLULAR_TYPE

noIPR
unintegrated

unintegrated
SSF52540	$\"[11-167]T$	SSF52540

","BeTs to 4 clades of COG1435COG name: Thymidine kinaseFunctional Class: FThe phylogenetic pattern of COG1435 is ------v-eb-h--gpo----Number of proteins in this genome belonging to this COG is 1","***** IPB001267 (Thymidine kinase cellular-type) with a combined E-value of 5.6e-41. IPB001267A 12-24 IPB001267B 81-95 IPB001267C 105-149 IPB001267D 173-187","Residues 4-187 are 48% similar to a (KINASE DNA ATP-BINDING SYNTHESIS) protein domain (PD100754) which is seen in KITH_BPT4.Residues 12-188 are 79% similar to a (KINASE THYMIDINE TRANSFERASE ATP-BINDING) protein domain (PD002207) which is seen in KITH_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 13:01:58 2002","Mon Feb 4 13:00:33 2002","Mon Jul 31 15:42:08 2006","Mon Feb 4 13:00:33 2002","Mon Feb 4 13:00:33 2002","Mon Feb 4 13:00:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0994 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 4 13:01:58 2002","","No significant hits to the NCBI PDB database.","SMU.1086c","","Residues 5 to 187 (E-value = 1.2e-62) place SMu0994 in the TK family which is described as Thymidine kinase (PF00265)","Mon Feb 4 13:00:33 2002","","","","McNab,R.Cloning and sequence analysis of thymidine kinase from the oralbacterium Streptococcus gordoniiFEMS Microbiol. Lett. 135 (1), 103-110 (1996)PubMed: 8598265","","Mon Feb 4 13:01:58 2002","1","","","SMU.1086c","682" "SMu0995","1031284","1031469","186","ATGCCATTTGTTAAAATTGACCTTTTTGAAGGCCGTAGCCAAGAACAAAAAATCCAGCTTGCTCGTGAAGTAACTGAAGTAGTGTCTCGTGTTGCAAAAGCACCTAAAGAAGCGATTCACGTTTTTATTAACGACATGCCGGAAGGAACCTATTATCCTCACGGAGAAATGAAGAAAAAAGGTTAG","9.20","1.47","6986","MPFVKIDLFEGRSQEQKIQLAREVTEVVSRVAKAPKEAIHVFINDMPEGTYYPHGEMKKKG","1031477","","4-oxalocrotonate tautomerase","Cytoplasm","Several matches in gapped BLAST to 4-oxalocrotonate tautomerase: residues 1-60 are 96% similar to the enzyme in S.thermophilus (gi12054924) and are 90% similar to the protein from S.pyogenes(gi15675116).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1079 (1e-27).","

InterPro
IPR004370
Family

4-oxalocrotonate tautomerase
PD404143	$\"[2-59]T$	Taut
PF01361	$\"[2-61]T$	Tautomerase

noIPR
unintegrated

unintegrated
SSF55331	$\"[2-60]T$	SSF55331

","No hits to the COGs database.","***** IPB001603 (Tautomerase enzyme) with a combined E-value of 1.2e-13. IPB001603 2-43 IPB001603 12-53","Residues 1-60 are 96% similar to a (4-OXALOCROTONATE ISOMERASE TAUTOMERASE) protein domain (PD404143) which is seen in Q9EVV8_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 13:06:56 2002","Mon Feb 4 13:06:16 2002","Wed Sep 27 14:40:00 2006","Mon Feb 4 13:06:16 2002","Mon Feb 4 13:06:16 2002","Mon Feb 4 13:06:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0995 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 4 13:06:16 2002","","No significant hits to the NCBI PDB database.","SMU.1087","","Residues 1 to 61 (E-value = 6.2e-27) place SMu0995 in the Tautomerase family which is described as Tautomerase enzyme (PF01361)","Mon Feb 4 13:06:16 2002","24379524","","","Chen,L.H., Kenyon,G.L., Curtin,F., Harayama,S., Bembenek,M.E.,Hajipour,G. and Whitman,C.P.4-Oxalocrotonate tautomerase, an enzyme composed of 62 amino acidresidues per monomerJ. Biol. Chem. 267 (25), 17716-17721 (1992)PubMed: 1339435Taylor,A.B., Czerwinski,R.M., Johnson,W.H. Jr., Whitman,C.P. andHackert,M.L.Crystal structure of 4-oxalocrotonate tautomerase inactivated by2-oxo-3-pentynoate at 2.4 A resolution: analysis and implicationsfor the mechanism of inactivation and catalysisBiochemistry 37 (42), 14692-14700 (1998)PubMed: 9778344","","Mon Feb 4 14:29:32 2002","1","","","SMU.1087","932" "SMu0996","1031551","1032486","936","TTGCAGGCACAACAAACTTTACATCTGATGGGGACAACGATTGATCTTATGGTTGAAGCCGACAATGCTAAAGAACTTGTTGAGACTGCTTGCCAACTTTTAAAGACTTACGAACATCGTTTCAGTGCCAATAGTGATGACTCAGAACTGATGGCTGTCAATCATCTGGCAGGTATCAAACCTGTTCAAGTTCAAGAAGATTTGTTCCAATTAATTAAAATTGGGAAAAAACATAGCCTTGAGCAGCCAAGCAATCTCAATATCACTATCGGACCTTTGGTGCAAGCTTGGCGGATAGGTTTTGACGATGCCAATATCCCCAGTAAATCTCTGATTGAAAAAAAATTGAAACTGATCGATCCTCAAAATATCAGACTGGATGAGAAAAAACAAACTGTCTTTTTATCCCAAAAGGGAATGAAGATTGATTTGGGATCTTTGGCAAAAGGTTACATTGCTGATAGAGTCATTTCTTATTTAAAACAGCAAGGTGCGTCTTCTGCTATGATTAATTTGGGTGGCAATCTTTTGGTTTATGGTCCTAATAAAAAACGTTCAAATGGTTTATGGTATATTGGGATTCAAGATCCTAAAAAACCACGAAACCAAAATATTGGTATTGTGAAAATTCATGGTCAATCTGTTGTTACTTCTGGCATTTATGAACGTCACCTACAGATTAATGGGAAAGATTATCACCATATTTTTGATAAAAATACAGGCTATCCAATAGAAACTCAAATGGCTAGTCTCAGTATTATCTCAGACTTATCACTTGATGGTGAGATTTGGACAACACGTTTATTTGGTTTACCAATACCGTTTGTTATGGAAACAATTAATCAAATCAGTCATATTGAAGGAATTATTATCACTAGAGATAATCGACTTGCTGTTTCAGATGGTCTTAAAAACACTTTTTCTGCCTTCCATTAA","9.00","4.36","34753","MQAQQTLHLMGTTIDLMVEADNAKELVETACQLLKTYEHRFSANSDDSELMAVNHLAGIKPVQVQEDLFQLIKIGKKHSLEQPSNLNITIGPLVQAWRIGFDDANIPSKSLIEKKLKLIDPQNIRLDEKKQTVFLSQKGMKIDLGSLAKGYIADRVISYLKQQGASSAMINLGGNLLVYGPNKKRSNGLWYIGIQDPKKPRNQNIGIVKIHGQSVVTSGIYERHLQINGKDYHHIFDKNTGYPIETQMASLSIISDLSLDGEIWTTRLFGLPIPFVMETINQISHIEGIIITRDNRLAVSDGLKNTFSAFH","1032494","","thiamine biosynthesis lipoprotein","Cytoplasm, Extracellular","Several matches in gapped BLAST to thiamine biosynthesis lipoprotein precursor: residues 5-311 are 50% similar to the enzyme in S.pyogenes (gi|15675115|). Residues 9-303 are 48% similar to the protein from S.pneumoniae (gi|15901320|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1081 (1e-102).","

InterPro
IPR003374
Family

ApbE-like lipoprotein
PF02424	$\"[1-296]T$	ApbE

","BeTs to 5 clades of COG1477COG name: Membrane-associated lipoprotein ApbE involved in thiamine biosynthesisFunctional Class: HThe phylogenetic pattern of COG1477 is -----qv-e--h-----lin-Number of proteins in this genome belonging to this COG is 1","***** IPB003374 (ApbE family) with a combined E-value of 3.6e-40. IPB003374A 82-100 IPB003374B 131-174 IPB003374C 208-262","Residues 141-303 are 22% similar to a (LIPOPROTEIN PRECURSOR THIAMINE) protein domain (PD315033) which is seen in Q9L1A6_STRCO.Residues 152-297 are 38% similar to a (PROTEOME COMPLETE YDHC) protein domain (PD399051) which is seen in Q9CII9_LACLA.Residues 1-151 are 42% similar to a (LIPOPROTEIN PROTEOME COMPLETE THIAMINE) protein domain (PD404776) which is seen in Q9CII9_LACLA.Residues 154-271 are 26% similar to a (PROTEOME APBE LIPOPROTEIN COMPLETE) protein domain (PD271928) which is seen in Q9PFR3_XYLFA.Residues 152-243 are 37% similar to a (LIPOPROTEIN BIOSYNTHESIS THIAMINE) protein domain (PD009949) which is seen in Q9CGI4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 14:49:34 2002","Mon Feb 4 14:49:34 2002","Tue Oct 15 12:16:54 2002","Mon Feb 4 14:48:11 2002","Mon Feb 4 14:48:11 2002","Mon Feb 4 14:48:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0996 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 4 14:48:11 2002","","No significant hits to the NCBI PDB database.","SMU.1088","","Residues 1 to 296 (E-value = 9.8e-45) place SMu0996 in the ApbE family which is described as ApbE family (PF02424)","Mon Feb 4 14:48:11 2002","24379525","","","Beck BJ, Downs DM.A periplasmic location is essential for the role of the ApbE lipoprotein in thiamine synthesis in Salmonella typhimurium.J Bacteriol. 1999 Dec;181(23):7285-90.PMID: 10572132 Beck BJ, Downs DM.The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium.J Bacteriol. 1998 Feb;180(4):885-91.PMID: 9473043 ","","Thu Mar 21 10:51:04 2002","1","","","SMU.1088","563" "SMu0997","1032511","1033113","603","ATGAAACTCATTGGATTAGTTGGTACAAACTCAAAAAAATCCACCAACCGCCAATTACTGCAATACATGCAAAAACATTTTGCTGATAAAGCTGACATTGAATTGCTTGAAATTAAAGATATTCCTATTTTTAATAAACCAGCAGACAAAAAAGTTCCAGAGCAAATACTTAAGATAGCTGAGAAAATTGAAGCTGCAGATGGTGTAATTATTGGTACACCTGAATACGATCATTCTATTCCAGCTGTATTAATGAGTGCTCTGGCTTGGCTGTCATACGGTATTTACCCGCTTCTTAATAAACCTGTCATGATTACTGGGGCTTCTTACGGAACCCTTGGTTCATCTCGAGCTCAGCTGCAACTTCGTCAAATTCTTAATGCGCCAGAAATTAAAGCGAATGTCCTTCCTGATGAATTTTTACTCTCTCACTCTCTGCAAGCATTTGACAAAGAAGGTAATCTTAATGATTTAGATACTTTCCAAAAACTTGATGCTATCTTTGACGATTTCCGTCTTTTTGTTAAAATCACCGAGAAACTATCAAGTGCCCAAGAACTTTTACATAAAGAAGCTGAAAATTTCAATTGGGAAAGTCTGTAA","5.40","-4.03","22469","MKLIGLVGTNSKKSTNRQLLQYMQKHFADKADIELLEIKDIPIFNKPADKKVPEQILKIAEKIEAADGVIIGTPEYDHSIPAVLMSALAWLSYGIYPLLNKPVMITGASYGTLGSSRAQLQLRQILNAPEIKANVLPDEFLLSHSLQAFDKEGNLNDLDTFQKLDAIFDDFRLFVKITEKLSSAQELLHKEAENFNWESL","1033121","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypotheticals and putative oxidoreductases. Residues 1-200 are 84% similar to gi|15903368|, a conserved hypothetical from S.pneumoniae. Residues 1-139are 33% similar to gi|16767134| from Salmonella typhimurium. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1082 (1e-96).","

InterPro
IPR005025
Domain

NADPH-dependent FMN reductase
PF03358	$\"[1-123]T$	FMN_red

InterPro
IPR014479
Family

NAD(P)H-dependent FMN reductase
PIRSF016214	$\"[1-185]T$	SSUE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[1-186]T$	G3DSA:3.40.50.360
SSF52218	$\"[1-172]T$	SSF52218

","BeTs to 6 clades of COG0431COG name: Predicted flavoproteinFunctional Class: RThe phylogenetic pattern of COG0431 is ----y--cebr---gp-----Number of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 2-129 are 50% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH PHOSPHODIESTERASE) protein domain (PD009603) which is seen in Q9CIJ0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 15:02:43 2002","Mon Feb 4 15:02:43 2002","Mon Feb 4 15:02:08 2002","Mon Feb 4 15:02:08 2002","","Mon Feb 4 15:02:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0997 is paralogously related (blast p-value < 1e-3) to SMu0161, SMu0998, SMu1282, and SMu0112, all conserved hypotheticals except SMu0162, a predicted fumarate reductase.","Mon Feb 4 15:02:08 2002","","No significant hits to the NCBI PDB database.","SMU.1089","","Residues 1 to 166 (E-value = 3.6e-16) place SMu0997 in the FMN_red family which is described as NADPH-dependent FMN reductase (PF03358)","Mon Feb 4 15:02:08 2002","24379526","","","","","","1","","","SMU.1089","806" "SMu0998","1033133","1034392","1260","ATGAAATTTGTAGGACTTGTAGGCTCAAATGCAGAACAATCATACAATCGCAAACTGTTAGAATACATCAGAAAACAATTTAAATTAAAATTTGAACTAGAATTGTTGGAAATTGATGAAGTACCAATGTTCAATCAAGATCAGAGTTGGAAAGACAGTTTCCAATTGCGTCTCCTATACAATAAAATTATACGTGCTGACGGGGTAATTATCGCTACACCTGAACATAACCACACCATTACTGCCGCTTTAAAGAGTGTTTTGGAATGGTTATCCTGTGAAGTCCATCCCTTTGAAAACAAACCTGTTATGATTGTTGGTGCTTCTTATTATGATCAAGGGACATCCCGAGCTCAGGTTCATTTGAGAAAAATTTTAGACGCACCCGGCGTCAATGCCTACACTCTTCCTGGTAATGAATTTTTACTTGGAAAAGCTAAGGAAGCCTTTGATGACAATGGCAATATTATTAATCAAGGAACTGTTGATTTCCTTGAAACTTGTTTAGATAATTTTATGAGCTATGTTGGAGTAGTATCAAAATTGCAAAAACCAAAACCAATTGAACCAGAAGATTTGGATTGTAATCATCCTATTGCTACAACCATTACTGAGGTTGATCCCGACGATCCTGAATGGGTTGAAAAAGTCGCTGAAATCACAGGTGCAGTGTCAGGTGATGCTTATGTTAAACTTGATCATGGTATTTTGACAGTCGATCAAATCAATATGTTCTTAAAAGCTATGCCTTTTGAGTTGACTTATGCGGATGACAATAATCAATTCTTGTATTACAATAACGCCCATCAAGATCCTGATACCATGTATGCTAAGCGTATCCCGGAACAGTCTGGAAATCGTTTGTCTACTGTTCATAATTCGCTTCCTGCAGGGCGTATGAAAAATGTTGAATGGGTTATTGGAACATTGCGCAATGGCAATCAGGAGTATGTCCGTACCCTTATTCCAAGCCCAAATCCCGCTGTTTTGAATACGCATAATTATCAAGCCATGTACTATGATGATGGTTCTTTTGCGGGAATCAATGAAATTGTCTTCAATTTCAAACCTTGGCTAGATTGGTATCTACAAACAACAGGACAAAGACTTGTTGGTGGTGCAGGCGGTGCCGATGCCACATCTGGTGCTTCTGACAGTGGTCATGGTGGAGGTAGCGATACTACTTCCGGTGCCTCTGATAGCAGTAGTCATAGCAATGAAACAGCTGCTGATGCCACATCTGGTGCTTCCGAACATTGA","4.70","-20.22","46386","MKFVGLVGSNAEQSYNRKLLEYIRKQFKLKFELELLEIDEVPMFNQDQSWKDSFQLRLLYNKIIRADGVIIATPEHNHTITAALKSVLEWLSCEVHPFENKPVMIVGASYYDQGTSRAQVHLRKILDAPGVNAYTLPGNEFLLGKAKEAFDDNGNIINQGTVDFLETCLDNFMSYVGVVSKLQKPKPIEPEDLDCNHPIATTITEVDPDDPEWVEKVAEITGAVSGDAYVKLDHGILTVDQINMFLKAMPFELTYADDNNQFLYYNNAHQDPDTMYAKRIPEQSGNRLSTVHNSLPAGRMKNVEWVIGTLRNGNQEYVRTLIPSPNPAVLNTHNYQAMYYDDGSFAGINEIVFNFKPWLDWYLQTTGQRLVGGAGGADATSGASDSGHGGGSDTTSGASDSSSHSNETAADATSGASEH","1034400","","conserved hypothetical protein","Cytoplasm, Extracellular","Matches in gapped BLAST to hypotheticals and to putative oxidoreductases. Residues 1-371 are 83% similar to gi|15903369|, a hypothetical from S.pneumoniae. Residues 1-176 are 29% similar to gi|16767134| from Salmonella typhimurium. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1083 (1e-180).","

InterPro
IPR005025
Domain

NADPH-dependent FMN reductase
PF03358	$\"[1-106]T$	FMN_red

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[1-187]T$	G3DSA:3.40.50.360
SSF52218	$\"[1-173]T$	SSF52218

","BeTs to 6 clades of COG0431COG name: Predicted flavoproteinFunctional Class: RThe phylogenetic pattern of COG0431 is ----y--cebr---gp-----Number of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 2-131 are 42% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH PHOSPHODIESTERASE) protein domain (PD009603) which is seen in Q9CIJ0_LACLA.Residues 230-352 are 26% similar to a (PROTEOME COMPLETE YQFA) protein domain (PD339357) which is seen in O30067_ARCFU.Residues 132-185 are 40% similar to a (PROTEOME COMPLETE YDHB) protein domain (PD397642) which is seen in Q9CIJ0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 4 15:09:55 2002","Mon Feb 4 15:10:28 2002","Mon Feb 4 15:09:55 2002","Mon Feb 4 15:07:27 2002","","Mon Feb 4 15:07:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu0998 is paralogously related (blast p-value < 1e-3) to SMu1282, SMu0162, SMu0997, SMu0161, SMu1053, and SMu0112 all conserved hypotheticals except SMu0162 a predicted fumarate reductase.","Mon Feb 4 15:07:27 2002","","No significant hits to the NCBI PDB database.","SMU.1090","","Residues 1 to 167 (E-value = 6.5e-14) place SMu0998 in the FMN_red family which is described as NADPH-dependent FMN reductase (PF03358)","Mon Feb 4 15:07:27 2002","24379527","","","","","","1","","","SMU.1090","564" "SMu0999","1034634","1036157","1524","ATGGAACAGAAGATTTTTAGCAAACGAAAAAGTAAGATTGCTGGGCTTTGTGGAGCTATTTTAACGACTACAGTTGTTGCCCTTGCGTCAGGTACTGTAATCGAGGCTGATGAGACAATAGAACAGCCTGTCGCAGCTGAGACTGTCTCGCAAGCTGATGGGGACAATCCCGAACAAACAACAAGCGTTCAACAAGAAACTGCTCCTCAACAAACGAAAACTTCTCAAAGCTCAGACGCAACCGTAGATAGTGAAGAGTCAGCAACTTCCCCATCTGATGAACAGACCGTAAGTCAAAATGATTCAAACTCATCATCTCAAATTGATCAAACGATAGCTGATACGAATCGCTCTGACTCTGATCATATTTCAAAAACATCAGCCGCTACAACTGAAGATCAAGAAGAGAAAGTTAATTCTGCAAAAGCACAAACTGCTGCCGCAACCAACAATCAAGACACTCGTTATAGTGCGAAAGATGCTTATGGCAATTCCAATTTTAACAAGACATTAACTGAATTTGGAAAAAATGCTAATGTTGCTGATGTAACCTATAATGGCGTGAGGGATGAATATATTGTAGTTAACGATCCTAGTGCTCCTTACGTTCCTAATGCAAACGAAATTGCAAAATACTTAAAGGAATATTTAACAGAACTCCGCAACATCAATAATATTGCTATTCCTGTGCCTTCTGTTGATCAGGTTATGCAAAAATACGCACAAGATCGGGCTAACGAAGAAGCCAATGAAAAAAACGGCTTGGATCATGATACTAATTTACCTATCCCTAATAATTTAACTTGGGTTGCCGAAGATGGACATTTGGATATGGATAGCAGCATTCAATCCAAAAGTCAAGAAGGCTATACACTTGCTTCTGATAAAGCAACCGCCTACTATCTAGCGCTTAACTGGTTTTCTGACTATTTTAATATTTACGATGACCCCAACGATGGCCTCAAATCGTTTGGACACGCTGTCAGTATTTTGTCAGACGGGGGAACTGGAATGGGCTTAGGTCTTGCTTCAGGTCAAGATAATGAAAAGGGAATGTGGTACGCACAATTGGAATTTGGTGGTAACGATAACGAAGATAATACCAACGATTTTTCATCTTTAAAAAACGGCAAGGGAGAATGGGTATTATATTATAAAGGAAGTCCTGTTAAGTTTCTTCCTAACACTACCTTTTGGTATGTAAAAAAAGGCACTTCCCCTGATGCAGCTTCTACTCCTCACAACAGTGATAAACCTTCATTCCAGTCATCTAAAGATCTTGACCCTAATTTCAAGGCCGATAATAGATTCCAAGAAGGAAAGGAAGCCTCTGTTCATCAGGCTATTCCTGCAACATTTAAATCTCATCGCGATGAAGTTGGTAATAAAGACCAAAATTCTCTTTCTGCTCAACTACCTGATACAGGAGTTCAAAAAAATAATCAATTAGCCTTGATAGCTTTAGGAACAGGCTTGATTTTACTTTCCGGACTTCTTCTTTCAAAAAGAAAATCCTTAAAATAA","4.50","-26.31","55051","MEQKIFSKRKSKIAGLCGAILTTTVVALASGTVIEADETIEQPVAAETVSQADGDNPEQTTSVQQETAPQQTKTSQSSDATVDSEESATSPSDEQTVSQNDSNSSSQIDQTIADTNRSDSDHISKTSAATTEDQEEKVNSAKAQTAAATNNQDTRYSAKDAYGNSNFNKTLTEFGKNANVADVTYNGVRDEYIVVNDPSAPYVPNANEIAKYLKEYLTELRNINNIAIPVPSVDQVMQKYAQDRANEEANEKNGLDHDTNLPIPNNLTWVAEDGHLDMDSSIQSKSQEGYTLASDKATAYYLALNWFSDYFNIYDDPNDGLKSFGHAVSILSDGGTGMGLGLASGQDNEKGMWYAQLEFGGNDNEDNTNDFSSLKNGKGEWVLYYKGSPVKFLPNTTFWYVKKGTSPDAASTPHNSDKPSFQSSKDLDPNFKADNRFQEGKEASVHQAIPATFKSHRDEVGNKDQNSLSAQLPDTGVQKNNQLALIALGTGLILLSGLLLSKRKSLK","1036165","","hypothetical protein (possible cell wall protein)","Extracellular, Cellwall","Matches weakly in gapped BLAST to sr and to anchorage subunit of a-agglutinin:residues 3-142 are 22% similar to the previously published enzyme in S.mutans (gi|297829|). Residues 22-165 are 24% similar to anchorage subunit of a-agglutinin in Saccharomyces cerevisiae (gi|6324372|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0675 (2e-05).","

InterPro
IPR001899
Domain

Surface protein from Gram-positive cocci, anchor region
PF00746	$\"[464-504]T$	Gram_pos_anchor
TIGR01167	$\"[471-506]T$	LPXTG_anchor
PS50847	$\"[472-507]T$	GRAM_POS_ANCHORING

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[274-495]T$	FtsX

","BeTs to 6 clades of COG0577COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0577 is AMt--QVcEBRHuj--OLinxNumber of proteins in this genome belonging to this COG is 7","***** IPB003838 (DUF214) with a combined E-value of 1.2e-12. IPB003838A 341-388","Residues 92-400 are 38% similar to a (OF PROTEOME COMPLETE CLUSTER) protein domain (PD025026) which is seen in Q9CH68_LACLA.Residues 1-70 are 60% similar to a (COMPLETE PROTEOME OF A) protein domain (PD414447) which is seen in Q9CH68_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:02:47 2002","Mon Feb 4 15:51:35 2002","Thu Sep 28 10:49:43 2006","Mon Feb 4 15:47:32 2002","Mon Feb 4 15:47:32 2002","Mon Feb 4 15:47:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1000 is paralogously related (blast p-value < 1e-3) to SMu0787,a predicted conserved hypothetical protein; SMu1245 and SMu1230, both predicted secretion ABC transport permeases; SMu1752,a predicted PsaB; SMu0631,a predicted hypothetical protein and SMu1935, a predicted conserved hypothetical protein (possible transmembrane protein).","Mon Feb 4 15:50:20 2002","","No significant hits to the NCBI PDB database.","SMU.1093","","Residues 274 to 495 (E-value = 4e-28) place SMu1000 in the FtsX family which is described as Predicted permease (PF02687)","Mon Feb 4 15:47:32 2002","24379529","","","","","","1","","","SMU.1093","" "SMu1001","1038011","1038667","657","ATGACATTGAAAACAAATAACCTCAGTTACTGGTACAATAACAATCCTGATGATTATCTTTTCAAAGAAGTCAATCTTGAATTTGAAAAAGGGAAAGTCTATGCTATCCTCGGGCAATCAGGTAGCGGAAAAACTACTTTTCTATCTCTTCTAGCAGGACTTGACAGTCCTAAAAAAGGAAAAATCCTTCTTAATAATCAAAATATTAGTGAAAAAGGCTTAACTGATTATCGTAAAAATGCTGTCTCAACCATTTTCCAATCCTATAATCTTTTGCCTTATATGACAGCTCAACAAAATGTTGAAACCGCACTTGATATTTCATCTGTCAAGACAACAAGTGAAAAAATTGTAACATTATTTGATAATGTTGGTATTTCTGAAGATTTGATAGATAAACCTGTCTTACATCTCTCCGGAGGTCAGCAACAAAGAGTTGCTATCGTGAGGGCGCTCGCTAGCGAACACAATATCATTATTGCTGATGAACCAACTGGTAATCTAGACGAAACAACAACCAAAGATATTGTTACTATTTTTAAAAAGATTGCCCATGAGCAGAAGAAAACGGTGATTATTGTTACGCATGAACGAGAAGTTGCTGATAGTTCTGATATTATTTTCGAATTACGCAAAAAAGAATTTACATTAATTTAA","6.20","-2.03","24425","MTLKTNNLSYWYNNNPDDYLFKEVNLEFEKGKVYAILGQSGSGKTTFLSLLAGLDSPKKGKILLNNQNISEKGLTDYRKNAVSTIFQSYNLLPYMTAQQNVETALDISSVKTTSEKIVTLFDNVGISEDLIDKPVLHLSGGQQQRVAIVRALASEHNIIIADEPTGNLDETTTKDIVTIFKKIAHEQKKTVIIVTHEREVADSSDIIFELRKKEFTLI","1038675","For other components see SMu1000 (MSD1).For other 'psa' genes see SMu1067 (psaB); SMu1068 (psaA);SMu1069 (psaR); SMu1171 (psaR); SMu1231 (psaA); SMu1752 (psaB) ; SMu1750 (psaR) and SMu1751 (psaA). ","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to ABC transport ATP-binding protein : residues 12-210 are 38% similar to the previously published ABC transport ATP-binding protein, PsaA in S.mutans (gi15625442). Residues 3-215 are 51% similar to the protein from Lactobacillus sakei (gi15217132).Residues 3-217 are 49% similar to the protein from B.subtilis (gi16077441). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0614 (2e-50).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[138-176]T$	ABC_transporter
PF00005	$\"[31-213]T$	ABC_tran
PS00211	$\"[138-152]T$	ABC_TRANSPORTER_1
PS50893	$\"[3-218]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-214]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-212]T$	G3DSA:3.40.50.300
PTHR19222	$\"[3-213]T$	PTHR19222
PTHR19222:SF17	$\"[3-213]T$	PTHR19222:SF17
SSF52540	$\"[3-215]T$	SSF52540

","BeTs to 15 clades of COG1136COG name: ABC-type (unclassified) transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1136 is AMt--QVCEBRHUJGPOLinxNumber of proteins in this genome belonging to this COG is 8","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.8e-32. IPB001140A 20-66 IPB001140B 135-173 IPB001140C 190-218","Residues 113-205 are 31% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in YN26_MYCTU.Residues 26-205 are 28% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in O27709_METTH.Residues 27-214 are 23% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD316735) which is seen in Q9PPY0_UREPA.Residues 65-135 are 54% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD390374) which is seen in Q9CH67_LACLA.Residues 74-111 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230) which is seen in P94411_BACSU.Residues 21-71 are 54% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in P94411_BACSU.Residues 138-179 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CH67_LACLA.Residues 91-203 are 28% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD033004) which is seen in O29198_ARCFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 5 14:23:51 2007","Wed Oct 23 13:37:57 2002","Thu Apr 5 14:23:51 2007","Tue Feb 5 11:03:18 2002","Tue Feb 5 11:03:18 2002","Tue Feb 5 11:03:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1001 is paralogously related (blast p-value < 1e-3) to SMu1751, SMu1068, SMu1246, SMu1231, SMu1288, SMu0786, SMu0916, SMu1920, SMu1762, SMu0218, SMu0884, SMu0731, SMu1380, SMu0517, SMu1003, SMu1210, SMu0849, SMu1949, SMu0594, SMu0971, SMu0418, SMu0235, SMu1950, SMu1023, SMu1079, SMu0390, SMu1811, SMu0805, SMu1428, SMu0258, SMu1518, SMu1710, SMu1037, SMu0907, SMu1036, SMu0234, SMu1064, SMu1757, SMu1517, SMu0944, SMu1316, SMu0475, SMu0374, SMu1724, SMu1959, SMu1649, SMu0823, SMu0596, SMu0024, SMu0950, SMu0825, SMu0752, SMu1545, SMu1410, SMu0987, SMu0216, SMu1065, SMu0986, SMu0476, SMu1306, SMu0976, SMu1093, SMu0335, SMu0837, SMu0824, SMu0224, SMu1202, SMu0164, SMu1050, SMu0836, SMu0666, SMu0729, and SMu1686, all ABC-related ATP-binding proteins.","Thu Mar 21 12:28:39 2002","Thu Apr 5 14:23:51 2007","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 120 1e-028pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 106 3e-024","SMU.1094","","Residues 31 to 213 (E-value = 7.7e-47) place SMu1001 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Feb 5 11:03:18 2002","24379530","","","","Tue Oct 29 13:54:36 2002","","1","","","SMU.1094","" "SMu1002","1040306","1038786","1521","ATGACCGATTTAATGACAACCTTCCAAAATCGCTTTGCTGACTGGACACAGTCCTTGTTAGAGCATTTACAAATATCTTTATTGTCACTTTTAATAGCCATTATCCTTGCTGTTCCTCTGGCTATCTTTATCAGTCATCGAAAGAGAATAGCAGAGATTATTTTACAAATTTCAGGGATTTTCCAAACGATTCCTTCTCTGGCTCTTTTAGGCTTATTCATCCCTTTTATGGGGATTGGAACGGTGCCAGCCGTAGCGGCTCTGGTTATCTATGCCCTTTTTCCAATTTTGCAAAATACCATCACTGGTCTAACAACTATTGACCCAAGTTTGGTCGAAGCTGGTCAAGCTTTCGGTATGACCAAGTGGGAGCGACTGAAAAAATTTGAATTAGCGCTGGCTATGCCAGTTATCATTTCTGGAGTAAGGACAGCGGCTGTTATGATTATTGGGACAGCGACCTTGGCAGCCTTGATTGGAGCTGGAGGGTTGGGTTCCTTCATTCTTCTTGGAATTGATCGTAACAACACTTCTCTGATTTTAATAGGAGCTATTTCTTCAGCTCTTTTAGCTATTCTTTTTAATCTTGCTATTAAGTTTTTAGAAAAAGCTTCGCTGAAAAAGATTATGCTTGCCTTTTTTATCATGTTGATTGGTTTGGGCGCCTCTTATCTTCCAAATGTGATTAAAACCAGTCAGAGTCAGAAAGAAATTGTCATTGCTGGTAAAATGGGACCTGAACCAGAAGTCCTGATTAATATGTATAAAGAATTAATTGAGCAAGATAGTCACCTATCAGTAAAAGTCAAACCTAATTTTGGAAAAACAACCTTTCTTTATGAAGCCCTAAAAAAAGGTGATATTGATATTTACCCAGAGTTTACTGGAACAATTACAAGTAGTCTTCTAAAAAATCCACCTAAAACGTCCAATAATCCTCAAACAGTTTACGAAGAAGCACGTGATGGTATTTTAAAACAGGACAATCTTGTCTATCTAAAGCCCATGAAATATCAAAATACCTATGCTGTAGCTGTTAAGAAATCATTTGCTAAAGAAAAAGGATTAAAGTCTATTTCTGATTTGAAAAAGGTTGAAAATACAGCAAAAGCAGGATTTACTCTCGAATTTAATGACCGAAAAGATGGAAACAAAGGATTGAAGAGTCTTTATGGACTTAATTTACAGGTGAGTACAATGGAACCTGCTTTGCGCTATCAAGCAATTAAGAGTGGTGATATTGACATCACTGACGCCTATTCAACAGATTCAGAAATCAAGGAATACGACTTGGTTACTCTCAAGGATAACAAAAATCTTTTCCCACCCTATCAGGGAGCACCTTTATTCAAAAAGAAATTGTTACAAAAACATCCTGAACTAAAAAAGATTCTGAATCGCTTAGCTGGAAAAATTACAGAAAATCAAATGAGCGACATGAATTATCAGGTTAAAGTCAAAGGAAAATCTGCTAAAACAGTAGCTCATCATTATCTCAAAAAAACAGGTTTGCTGAAATAA","10.40","20.46","55778","MTDLMTTFQNRFADWTQSLLEHLQISLLSLLIAIILAVPLAIFISHRKRIAEIILQISGIFQTIPSLALLGLFIPFMGIGTVPAVAALVIYALFPILQNTITGLTTIDPSLVEAGQAFGMTKWERLKKFELALAMPVIISGVRTAAVMIIGTATLAALIGAGGLGSFILLGIDRNNTSLILIGAISSALLAILFNLAIKFLEKASLKKIMLAFFIMLIGLGASYLPNVIKTSQSQKEIVIAGKMGPEPEVLINMYKELIEQDSHLSVKVKPNFGKTTFLYEALKKGDIDIYPEFTGTITSSLLKNPPKTSNNPQTVYEEARDGILKQDNLVYLKPMKYQNTYAVAVKKSFAKEKGLKSISDLKKVENTAKAGFTLEFNDRKDGNKGLKSLYGLNLQVSTMEPALRYQAIKSGDIDITDAYSTDSEIKEYDLVTLKDNKNLFPPYQGAPLFKKKLLQKHPELKKILNRLAGKITENQMSDMNYQVKVKGKSAKTVAHHYLKKTGLLK","1038800","For other components see SMu1003 (NBD1)For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762 (atmD);SMu0971 (atmD); SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).For other 'pst' genes see SMu1037 (pstB) ; SMu1038 (pstC);SMu1039 (pstC); SMu1040 (pstS) and SMu1036 (pstB).","proline/glycine betaine ABC permease and solute binding protein ","Membrane, Cytoplasm","Matches in gapped BLAST to phosphate ABC transporter (permease protein):residues 48-129 are 28% similar to the previously published amino acid ABC transport permease,AtmE in S.mutans (gi15625432). Residues 1-294 are 88% similar to the enzyme in S.pyogenes (gi15675203) and are 86% similar to the protein from S.pneumoniae (gi15901252).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2130 (1e-161).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[19-211]T$	BPD_transp_1
PS50928	$\"[19-202]T$	ABC_TM1

InterPro
IPR007210
Domain

Substrate-binding region of ABC-type glycine betaine transport system
PF04069	$\"[236-501]T$	OpuAC

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[231-393]T$ $\"[406-506]T$	G3DSA:3.40.190.10
SSF53850	$\"[236-506]T$	SSF53850

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 96-148 are 79% similar to a (TRANSPORT PERMEASE COMPLETE TRANSMEMBRANE) protein domain (PD001159) which is seen in Q9XBN5_STRPN.Residues 233-506 are 70% similar to a (COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD009904) which is seen in Q9XBN5_STRPN.Residues 234-484 are 24% similar to a (PROTEOME COMPLETE) protein domain (PD129167) which is seen in O69725_MYCTU.Residues 46-94 are 71% similar to a (TRANSPORT PERMEASE PROTEOME COMPLETE) protein domain (PD388919) which is seen in Q9XBN5_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 13 14:15:51 2007","Tue Mar 13 14:15:27 2007","Thu Feb 22 14:23:05 2007","Tue Feb 5 11:20:07 2002","","Tue Feb 5 11:20:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1002 is paralogously related (blast p-value < 1e-3) to SMu1921, SMu1922 and SMu1923,all predicted glycine betaine / carnitine / choline ABC transporter permeases (membrane p); SMu0970, a predicted glycine-betaine binding permease protein; SMu1761,a predicted amino acid ABC transport permease; SMu1038,a predicted phosphate ABC transporter (permease protein); SMu0885,a predicted spermidine / putrescine ABC transporter (permease protein); and SMu0595, a predicted ABC transporter,permease protein/possible taurine transport system permease protein.","Tue Feb 5 11:21:29 2002","","No significant hits to the NCBI PDB database.","SMU.1095c","","Residues 19 to 211 (E-value = 7.9e-24) place SMu1002 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)Residues 237 to 506 (E-value = 8e-92) place SMu1002 in the OpuAC family which is described as Substrate binding domain of ABC-type glycine betaine transport system (PF04069)","Thu Feb 22 14:23:05 2007","","","","","","","1","","","SMU.1095c","" "SMu1003","1041028","1040306","723","ATGATTCGATTTGAAAATATTACTAAATCTTACGGGGATAACCGGGTCATTGCCGATCTTAACTTTGAAATTGCCAAGGGAGAATTCTTTGTTTTGATTGGTCCCAGTGGCAGCGGTAAAACGACTACCCTCAAGATGATTAATCGCTTAATCACTCCCAGTCAAGGAGATATTTATCTAAATGATAAAAACATCACTGACATTTCTTTAAGAGAATTACGTTTAGATATGGGTTATGTTCTTCAGCAAATTGCTCTTTTCCCCAATCTGACTGTCAGAGAAAATATTGAATTGATTCCTGAAATGAAGGCTTGGTCAAAAGCAGATCGACTCGAAAAAACGAAGAAATTACTTGATAAAGCTGGCTTGCCAGCAGATAAGTATTTGGAACGTTATCCACGTGACCTATCAGGTGGTGAGCAACAACGGGTAGGTATTCTACGTGCCATTATTGCAAATCCCCATATTCTTTTAATGGACGAGCCTTTTTCAGCCCTGGATCCTATTTCGAGAAAACAACTACAAGATTTGACACTCTCTTTACAAAAAGAATTAGGAATGACAGTTGTTTTTGTAACGCATGATATTGAAGAAGCCAAAAAGTTAGCAGATCGAATTGCTATTTTTCAAAAGGGGCGGATTATTCAATTGGCTAGTCCTAAAGATATGGCGCAAAATCCGGTCAATGATTTTGTGGCAGATTTATTTGGAGGTGATAACTAA","6.60","-0.51","27057","MIRFENITKSYGDNRVIADLNFEIAKGEFFVLIGPSGSGKTTTLKMINRLITPSQGDIYLNDKNITDISLRELRLDMGYVLQQIALFPNLTVRENIELIPEMKAWSKADRLEKTKKLLDKAGLPADKYLERYPRDLSGGEQQRVGILRAIIANPHILLMDEPFSALDPISRKQLQDLTLSLQKELGMTVVFVTHDIEEAKKLADRIAIFQKGRIIQLASPKDMAQNPVNDFVADLFGGDN","1040320","For other components see SMu1002 (MSD1).For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762 (atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).For other 'pro' genes see SMu1792 (proC); SMu0407 (proB);SMu0408 (proA) and SMu1623 (proS) . ","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to ABC transporter (ATP-binding protein) : residues 17-234 are 35% similar to the previously published amino acid ABC transport ATP-binding protein, AtmD in S.mutans (gi|15625431|).Residues 1-239 are 65% similar to the protein from S.pyogenes (gi|15675110|).Residues 1-238 are 62% similar to the protein from S.pneumoniae (gi|15903720|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2129 (2e-88).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[136-177]T$	ABC_transporter
PF00005	$\"[27-212]T$	ABC_tran
PS00211	$\"[136-150]T$	ABC_TRANSPORTER_1
PS50893	$\"[2-236]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-213]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-237]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-240]T$	PTHR19222
PTHR19222:SF48	$\"[2-240]T$	PTHR19222:SF48
SSF52540	$\"[1-237]T$	SSF52540

","BeTs to 5 clades of COG1125COG name: ABC-type proline/glycine betaine transport systems, ATPase componentsFunctional Class: EThe phylogenetic pattern of COG1125 is a-------EBr-uj--o----Number of proteins in this genome belonging to this COG is 3","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.2e-33. IPB001140A 16-62 IPB001140B 133-171 IPB001140C 189-218","Residues 181-220 are 57% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9CH91_LACLA.Residues 2-222 are 27% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD313900) which is seen in Q9WZT4_THEMA.Residues 74-133 are 63% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9CH91_LACLA.Residues 136-215 are 33% similar to a (ABC TRANSPORTER) protein domain (PD058053) which is seen in O69995_STRCO.Residues 116-214 are 37% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9Y979_AERPE.Residues 181-223 are 51% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472) which is seen in Q9V286_PYRAB.Residues 86-215 are 28% similar to a (LACF) protein domain (PD194047) which is seen in O97278_PLAFA.Residues 181-220 are 57% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in O29281_ARCFU.Residues 115-231 are 22% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 17-67 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9XBN6_STRPN.Residues 135-175 are 87% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CH91_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 23 13:39:17 2002","Wed Oct 23 13:39:17 2002","Tue Oct 15 12:22:19 2002","Tue Feb 5 12:50:19 2002","Tue Feb 5 12:50:19 2002","Tue Feb 5 12:50:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1003 is paralogously related (blast p-value < 1e-3) to SMu1920, SMu0971, SMu0517, SMu0884, SMu1428, SMu0594, SMu0731, SMu1380, SMu0849, SMu1762, SMu1079, SMu0805, SMu0418, SMu0218, SMu1751, SMu0235, SMu1649, SMu1068, SMu0950, SMu0786, SMu0390, SMu1246, SMu1231, SMu0374, SMu1949, SMu1210, SMu0916, SMu1517, SMu1288, SMu1036, SMu1950, SMu0234, SMu0944, SMu1023, SMu1518, SMu1037, SMu0596, SMu0216, SMu1001, SMu0335, SMu1710, SMu0976, SMu1316, SMu0752, SMu1410, SMu1757, SMu0258, SMu0907, SMu0824, SMu0836, SMu1050, SMu1064, SMu0987, SMu0475, SMu1093, SMu1724, SMu0164, SMu1545, SMu0476, SMu0986, SMu0825, SMu1811, SMu0666, SMu0837, SMu1065, SMu0224, SMu0024, SMu0823, SMu1959, SMu1306, SMu0729, and SMu1686, all with ATP-binding capabilities.","Tue Feb 5 12:55:51 2002","Tue Feb 5 12:50:19 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 174 8e-045pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 128 8e-031","SMU.1096c","","Residues 27 to 212 (E-value = 9.6e-63) place SMu1003 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Feb 5 12:50:19 2002","","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 1537846Russell RR, Ferretti JJNucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans.J Gen Microbiol 1990 May;136 ( Pt 5):803-10PubMed: 2380687 PMID: 2380687Aduse-Opoku J, Tao L, Ferretti JJ, Russell RRBiochemical and genetic analysis of Streptococcus mutans alpha-galactosidaseJ Gen Microbiol 1991 Apr;137 ( Pt 4):757-64PubMed: 1649890PMID: 1649890 Ferretti JJ, Huang TT, Russell RRSequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.Infect Immun 1988 Jun;56(6):1585-8PubMed: 2967248 PMID: 2967248","","Tue Apr 2 17:27:41 2002","","1","","","SMU.1096c","" "SMu1004","1041507","1041025","483","ATGACGAAATCACAAAAGCAGACAAAGCAATATTTACGTATCTTTGATCAGCAGATGTCTCTTTATGAGCATTACGCTCGAAAGAACAGTCTGCAAAGCAAATCTCTTTTTATCCTTCTTTGGCTTTATTATAATCCACAAGGAATCACACAAAAACAAATTGTTGAAAAAACTTATTCAACTAAACAAGTGGTTAACGCTACTTTAAAAAGATGGAATGAAAAAAATTATATCGTTTTTCTCAAGTCACAAACAGATCGTCGTGAAAAGAAAATAATTTTATCTTCTCAAGGTCAAGAATATGCTGCATCCATTATTGCTCCTTTAGAGAAAATGGAAGAAGCCGCCTTTAATAGTTTGTCTATTCAAGAGCAACAAACAATGATTCAATTGACGGGACATTATTATCAAGCTTTATTATCACAAATGCAGCTTTATTTTGTTCAAGGAGAAGGAGAAAAAGCTACAAAGGAGAAGTTATGA","10.40","8.47","18877","MTKSQKQTKQYLRIFDQQMSLYEHYARKNSLQSKSLFILLWLYYNPQGITQKQIVEKTYSTKQVVNATLKRWNEKNYIVFLKSQTDRREKKIILSSQGQEYAASIIAPLEKMEEAAFNSLSIQEQQTMIQLTGHYYQALLSQMQLYFVQGEGEKATKEKL","1041039","","transcriptional regulator","Membrane, Extracellular","Matches weakly in gapped BLAST to transcriptional regulators from E.coli: residues 1-131 are 22% similar to gi|15803257| of E.coli.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1332 (4e-07).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PF01047	$\"[31-101]T$	MarR
SM00347	$\"[24-125]T$	HTH_MARR
PS50995	$\"[1-137]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-122]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-124]T$	SSF46785

","BeTs to 4 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class: KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 13:01:53 2002","Tue Feb 5 13:02:56 2002","Tue Oct 15 12:23:43 2002","Tue Feb 5 12:58:32 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1004 is paralogously related (blast p-value < 1e-3) to SMu0835, SMu1787, and SMu0111, all predicted transcriptional regulators.","Tue Feb 5 12:58:32 2002","","No significant hits to the NCBI PDB database.","SMU.1097c","","Residues 31 to 135 (E-value = 3.6e-09) place SMu1004 in the MarR family which is described as MarR family (PF01047)","Tue Feb 5 12:58:32 2002","24379533","","","","","","1","","","SMU.1097c","" "SMu1005","1042469","1041507","963","ATGAAAGCAGTACTCGTTGAACAACCGGGCTCATCTGAACAATTAAAAGTTGTGGAAAGAGAGATTCCTAAAATTAAGGAAGGTTGGTCTCTGGTAAAAATTAAGGGATTCGGTATCAATCGTTCTGAAATTTTTACGCGTAAGGGTTACTCGCCGTCTGTTGTTTTTCCAAGGGTTTTAGGCATTGAATGTGTCGGTATTATTGAAGAAACATCGGATAAAAACCATTTCTTCCATGGACAGAAAGTTGTTTCCATTATGGGAGAGATGGGAAGAGCATTCGATGGCAGCTATGCTGAATATGTCCTTTTGCCAAATGAACAAATTTACCCTATAAAAACAAATCTAACTTGGGATAAGTTGGCAGCAGCTCCTGAGAGCTATTATACAGCTTACGGTGCCTATAAAAATTTGAAATTGAAAAAGCAGGATCTTGTTCTTGTTCGAGCAGGAGCAAGCGGTGTTGCTTTAGCTTTTCTCAATTTATTAAAGGCTTCCTTGCCTGAGATCAAGGTGACTGCCAGTGTACGTTCTCTTGCAAAAAAGCAACAACTTTTAGATAGCGGCTATGATGAGGTTATTATTGACCGAGATAGCTGTTTACAAACGAAGCAAAAATTTGATAAGGTTTTGGATTTGATAGGTCCTGCTTGTATTGATGATACTTTAAACCATGTTGCTGATGGTGGTATTATCTGTCTAGTTGGTTTATTAGGCGGTCAATGGACCTTGGACAATTTTGATCCCATCATGGCTCTGCAAAATAACATTTATCTAACAACTTTCTATTCTGGCAATATCAATTTAAACAAATTGCAAGAGCTCTTTGATTTTATTGCTAAATATGCTGTTCCTATTAAGGTGGAAAAGATTTTTACTATTGATCACATTAAAGAAGCACATGACTACTTAGAAAGTCCTCAAGCTTTTGGCAAAGTTATTGTATTGAACGGAGTTGCTTAA","7.00","0.00","35538","MKAVLVEQPGSSEQLKVVEREIPKIKEGWSLVKIKGFGINRSEIFTRKGYSPSVVFPRVLGIECVGIIEETSDKNHFFHGQKVVSIMGEMGRAFDGSYAEYVLLPNEQIYPIKTNLTWDKLAAAPESYYTAYGAYKNLKLKKQDLVLVRAGASGVALAFLNLLKASLPEIKVTASVRSLAKKQQLLDSGYDEVIIDRDSCLQTKQKFDKVLDLIGPACIDDTLNHVADGGIICLVGLLGGQWTLDNFDPIMALQNNIYLTTFYSGNINLNKLQELFDFIAKYAVPIKVEKIFTIDHIKEAHDYLESPQAFGKVIVLNGVA","1041521","","oxidoreductase","Cytoplasm","Matches in gapped BLAST to oxidoreductase and alcohol dehydrogenase: residues 2-315 are 28% similar to quinone oxidoreductase in Mesorhizobium loti (gi|13475965|). Residues 1-313 are 27% similar to the protein from Bacillus subtilis (gi|16078904|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0054 (3e-06).","

InterPro
IPR002085
Family

Alcohol dehydrogenase superfamily, zinc-containing
PTHR11695	$\"[14-319]T$	ADH_Sf_Zn

InterPro
IPR011032
Domain

GroES-like
SSF50129	$\"[1-148]T$	GroES_like

InterPro
IPR013149
Domain

Alcohol dehydrogenase, zinc-binding
PF00107	$\"[142-281]T$	ADH_zinc_N

InterPro
IPR013154
Domain

Alcohol dehydrogenase GroES-like
PF08240	$\"[27-112]T$	ADH_N

noIPR
unintegrated

unintegrated
G3DSA:3.90.180.10	$\"[1-165]T$	G3DSA:3.90.180.10
PTHR11695:SF21	$\"[14-319]T$	PTHR11695:SF21
SSF51735	$\"[115-283]T$	SSF51735

","BeTs to 4 clades of COG0604COG name: NADPH:quinone reductase and related Zn-dependent oxidoreductasesFunctional Class: C,RThe phylogenetic pattern of COG0604 is ----Yq--ebR----------Number of proteins in this genome belonging to this COG is 3","***** IPB002328 (Zinc-containing alcohol dehydrogenase) with a combined E-value of 5.3e-07. IPB002328A 14-45 IPB002328B 57-82 IPB002328D 109-156","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 13:31:23 2002","Tue Feb 5 13:08:30 2002","Tue Oct 15 12:24:34 2002","Tue Feb 5 13:08:30 2002","Tue Feb 5 13:08:30 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1005 is paralogously related (blast p-value < 1e-3) to SMu0583, and SMu0664,both predicted oxidoreductases and SMu0107, a predicted alcohol dehydrogenase class III.","Tue Feb 5 13:08:30 2002","","No significant hits to the NCBI PDB database.","SMU.1098c","","Residues 10 to 317 (E-value = 1.1e-35) place SMu1005 in the ADH_zinc_N family which is described as Zinc-binding dehydrogenase (PF00107)","Tue Feb 5 13:08:30 2002","24379534","","","","","","1","","","SMU.1098c","" "SMu1006","1043866","1042742","1125","ATGAAAATCAAAAAATCTTATGTTGCTTATCCTGTTTTGGTCTTTGTCATTTGTTATGCAATTTTGGCAAACTGGTCAGCAGGAGCTAAAATATTGAATACTTTTTTGTCTGCTCTATCTCCTTTTTTAACAGGGGCTGCCATTGGTTATATTGTTAACATTGTTATGAGTGCCTATGAAAGACTTTATGATAAATTGATTAAGTCACAAAGTCTTTTGAAGGCTAAACGGCCTTTGACTATGGTTTTAGCTTATGCAACTTTTGTGCTTGTTGTCGTTCTCATTTTTACCATTGTTCTACCAGATTTGATTGCCAGCCTTAAATCCTTGCTGTCTATTAACCCAAAGGATATTCAAAATATCATCAATGAAGTCCAACACAATAAATGGGTTTCCAAAATGTTAGCATCTTTTGGAGGAGATACACAAATTAGCAGCCTCATTTCTAATTACAGCCGACAAATTTTGAGTCAATTTTTGAGTGTTTTAACAAATGTACTAACTTCGGTTACTTCAATAGCATCAGCTTTAATTTCAATTTTTGTTAGTATTATCTTTTCCATGTATGTTCTAGCTAATAAAGAGAAATTAGGGCGTCAGTTTAATCTTCTAATTGATACTTACCTTGGTAAATATTCTGGGACAGTTCATTATCTTGTTGGTATTTTGCACAGTCGCTTTCATGGTTTTTTTGTTGGTCAGACTTTAGAAGCCATGATCTTAGGAACATTGACAGCTATTGGTATGATGCTATTTAACTTACCTTATGCAGCGACAATTGGGATCTTGATTGCTTTTACTGCTCTGATACCAGTTGTTGGTGCTTATATTGGTGTTACTATTGGAACTATTTTAATTTTGACACAGTCCTTCTCACAGGCAGTCGTCTTTCTTGTCTTTGTTATTTTGCTGCAACAGTTTGAAGGCAATGTGATTTATCCAAGAGTTGTTGGCAGCTCTATTGGTTTACCATCTATGTGGGTTCTGCTGGCCATTACTATTGGCGGTGCTTTAGCAGGTTTAGTTGGTATGCTGATGGCTGTACCTATTTTAGCCAGCCTTTATCAAATTATTAAAGATCATGTTTATCAAAAGCAAACACAAAAAGCTTCCCAAGAGAAATAA","10.50","14.14","40839","MKIKKSYVAYPVLVFVICYAILANWSAGAKILNTFLSALSPFLTGAAIGYIVNIVMSAYERLYDKLIKSQSLLKAKRPLTMVLAYATFVLVVVLIFTIVLPDLIASLKSLLSINPKDIQNIINEVQHNKWVSKMLASFGGDTQISSLISNYSRQILSQFLSVLTNVLTSVTSIASALISIFVSIIFSMYVLANKEKLGRQFNLLIDTYLGKYSGTVHYLVGILHSRFHGFFVGQTLEAMILGTLTAIGMMLFNLPYAATIGILIAFTALIPVVGAYIGVTIGTILILTQSFSQAVVFLVFVILLQQFEGNVIYPRVVGSSIGLPSMWVLLAITIGGALAGLVGMLMAVPILASLYQIIKDHVYQKQTQKASQEK","1042756","","permease","Membrane, Cytoplasm","Matches in gapped BLAST to permeases:residues 4-359 are 21% similar to the previously published enzyme in S.mutans (gi2952526). Residues 5-370 are 25% similar to the enzyme in Clostridium acetobutylicum (gi15894017). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1102 (1e-104).","

InterPro
IPR002549
Family

Protein of unknown function UPF0118
PTHR21716	$\"[111-363]T$	UPF0118
PF01594	$\"[15-362]T$	UPF0118

","BeTs to 9 clades of COG0628COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0628 is amtK-qVCEBRHuj--ol--xNumber of proteins in this genome belonging to this COG is 3","***** IPB002549 (Domain of unknown function DUF20) with a combined E-value of 3e-14. IPB002549A 87-99 IPB002549B 314-351","Residues 154-332 are 24% similar to a (TRANSMEMBRANE COMPLETE PROTEOME PERMEASE INTEGRAL) protein domain (PD002159) which is seen in YUEF_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 13:42:33 2002","Tue Feb 5 13:42:59 2002","Tue Sep 12 17:07:29 2006","Tue Feb 5 13:37:19 2002","Tue Feb 5 13:37:19 2002","Tue Feb 5 13:37:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1006 is paralogously related (blast p-value < 1e-3) to SMu1544, a predicted permease; SMu1324,a predicted membrane protein and SMu1021, a predicted sugar ABC transporter (permease protein).","Tue Feb 5 13:37:19 2002","","No significant hits to the NCBI PDB database.","SMU.1100c","","Residues 15 to 362 (E-value = 4.7e-38) place SMu1006 in the UPF0118 family which is described as Domain of unknown function DUF20 (PF01594)","Tue Feb 5 13:37:19 2002","24379535","","","","Tue Sep 12 17:07:29 2006","","1","","","SMU.1100c","371" "SMu1007","1045687","1044251","1437","ATGATAAAATTAAAACCGTTTCCACAGGGATTTTTATGGGGTGGTGCAACAGCTGCTAACCAATGCGAAGGCGCCTATAATGTTGATGGCCGTGGTTTAGCCAATGTTGACGTTGTGCCAATCGGTGAAGATCGCTTTCCGATTATTGCTGGTAAAAAGAAGATGTTTGACTTTGAAGAAGGTTATTTTTATCCAGCTAAAGATTCCATTGATATGTACCATCATTTCAAAGAAGATATCGCTCTTTTTGGAGAAATGGGCTTCAAAACTTATCGTCTTTCGATTGCTTGGACGCGTATTTTTCCACAGGGAGATGAGTTAGAACCTAATGAAGCTGGTTTGCAATTCTATGAGGATTTGTTTAAGGAATGTCATAAATACGGCATTGAACCATTGGTGACCATAACACATTTTGATTGCCCTATGCACTTGATTGAAGAATATGGTGGTTGGCGTAATCGTAAGATGTTAGAATTTTATGAGCGTCTTTGCCGTACACTTTTTACACGATTTAAGGGTCTTGTTAAATATTGGTTGACATTCAATGAAATCAATATGATTCTTCATGCACCATTTATGGGAGCAGGTTTGTATTTTGAAGAAGGTGAAAACGAAGAAGAGGTGAAGTATCAATCTGCTCATCATGAATTGGTCGCGTCAGCTATTGCTACTAAGCTAGCACATGAAATTGATGCAGAAAATCAAGTTGGCTGTATGTTGGCAGCTGGACAGTATTATCCAAATACTTGCAATCCTAATGATTATTGGAAAGCTATGAAGGAAGATCGTTCTAATTATTTCTTTATTGATGTCCAGGCGCGGGGAGAGTATCCTAATTATGCTAAAAAGCAATTTGAACGTGATGGTCTGAATATTATCATGACGCAAGAAGATTTACAGCTCTTAAAAGAAAATACAGTTGACTTTGTTTCTTTCTCTTATTATTCAAGCCGAGTGGCTTCTGCTGATCCAAAAATTAACGACGAAACGCAAGGGAATATCTTTGCCTCTATTAAAAATCCTTACTTGTCATCATCTGAATGGGGTTGGCAAATTGATCCGCTCGGTCTTCGGATTACTCTTAATACCATTTGGGATCGCTATCAAAAGCCAATGTTCATTGTTGAAAATGGTCTTGGAGCAATTGATAAGCCAGATAAAAATGGCTATGTTGAAGACGATTATCGGATTGATTACTTGCGCGAACACATTAAGGCTATGAATGCTGCGATTAATGAAGATGGTGTTCAGCTCCTAGGTTATACCACTTGGGGCTGTATTGACCTTGTTTCTGCAGGTACGGGTGAAATGAAAAAACGCTATGGCTTCATTTATGTTGACCGTGATAATGCTGGTAATGGCACTCTTAAGCGCTCTAAAAAGAAATCGTTTGACTGGTATAAGAAAGTCATTGCTTCTAATGGAACAGACTTGTAG","5.10","-13.87","55100","MIKLKPFPQGFLWGGATAANQCEGAYNVDGRGLANVDVVPIGEDRFPIIAGKKKMFDFEEGYFYPAKDSIDMYHHFKEDIALFGEMGFKTYRLSIAWTRIFPQGDELEPNEAGLQFYEDLFKECHKYGIEPLVTITHFDCPMHLIEEYGGWRNRKMLEFYERLCRTLFTRFKGLVKYWLTFNEINMILHAPFMGAGLYFEEGENEEEVKYQSAHHELVASAIATKLAHEIDAENQVGCMLAAGQYYPNTCNPNDYWKAMKEDRSNYFFIDVQARGEYPNYAKKQFERDGLNIIMTQEDLQLLKENTVDFVSFSYYSSRVASADPKINDETQGNIFASIKNPYLSSSEWGWQIDPLGLRITLNTIWDRYQKPMFIVENGLGAIDKPDKNGYVEDDYRIDYLREHIKAMNAAINEDGVQLLGYTTWGCIDLVSAGTGEMKKRYGFIYVDRDNAGNGTLKRSKKKSFDWYKKVIASNGTDL","1044265","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0891 (bglB); SMu0892 (bglB); SMu0893 (bglC); SMu0895 (bglA); SMu1285 (bglC); SMu1454 (bglG) and SMu1456 (bglA).","6-phospho-beta-glucosidase, required for arbutin uptake and metabolism","Cytoplasm, Extracellular","Matches in gapped BLAST to beta-glucosidase:residues 7-478 are 53% similar to the previously published enzyme in S.mutans (gi:9622923). Residues 6-478 are 70% similar to phospho-beta-glucosidase from Lactococcus lactis (gi:15673653).Residues 5-478 are 67% similar to the enzyme from Clostridium acetobutylicum (gi:15894687). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1103 (0.0).","

InterPro
IPR001360
Family

Glycoside hydrolase, family 1
PR00131	$\"[306-320]T$ $\"[372-380]T$ $\"[393-404]T$ $\"[415-432]T$ $\"[440-452]T$	GLHYDRLASE1
PTHR10353	$\"[7-477]T$	Glyco_hydro_1
PF00232	$\"[3-476]T$	Glyco_hydro_1
PS00572	$\"[372-380]?$	GLYCOSYL_HYDROL_F1_1
PS00653	$\"[11-25]T$	GLYCOSYL_HYDROL_F1_2

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[7-471]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
PTHR10353:SF3	$\"[7-477]T$	PTHR10353:SF3
SSF51445	$\"[6-477]T$	SSF51445

","No hits to the COGs database.","***** IPB001360 (Glycoside hydrolase family 1) with a combined E-value of 2.2e-53. IPB001360A 7-25 IPB001360B 71-104 IPB001360C 267-278 IPB001360D 308-317 IPB001360E 414-441","Residues 195-298 are 27% similar to a (BGLB PHOSPHO-BETA-GLUCOSIDASE) protein domain (PD295003) which is seen in Q9X564_ENTFC.Residues 116-183 are 47% similar to a (BGLB PHOSPHO-BETA-GLUCOSIDASE) protein domain (PD350257) which is seen in Q9X564_ENTFC.Residues 69-104 are 77% similar to a (BETA-GLUCOSIDASE HYDROLASE AMYGDALASE) protein domain (PD235643) which is seen in O50658_BBBBB.Residues 7-42 are 63% similar to a (II PHOSPHO-BETA-GALACTOSIDASE) protein domain (PD246278) which is seen in O50658_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 17:22:39 2006","Mon Feb 27 11:11:18 2006","Mon Feb 27 13:28:26 2006","Tue Feb 5 13:47:42 2002","Tue Feb 5 13:47:42 2002","Tue Feb 5 13:47:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1007 is paralogously related (blast p-value < 1e-3) to SMu0895, SMu1456, and SMu1355 all predicted phospho-beta-glucosidases.","Tue Feb 5 14:00:52 2002","Mon Feb 27 11:11:18 2006","pdb3PBGA Chain A, 6-Phospho-Beta-Galactosidase Form-C >gi239... 221 1e-058pdb2PBG 6-Phospho-Beta-D-Galactosidase Form-B 220 2e-058pdb1TR1A Chain A, Crystal Structure Of E96k Mutated Beta-Gluc... 220 3e-058","SMU.1102c","","Residues 3 to 476 (E-value = 3.3e-142) place SMu1007 in the Glyco_hydro_1 family which is described as Glycosyl hydrolase family 1 (PF00232)","Tue Feb 5 13:47:42 2002","","","Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337Cote CK, Honeyman AL.The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549Cote CK, Cvitkovitch D, Bleiweis AS, Honeyman AL.A novel beta-glucoside-specific PTS locus from Streptococcus mutans that is not inhibited by glucose.Microbiology. 2000 Jul;146 ( Pt 7):1555-63.PMID: 10878120","Hall,B.G. and Xu,L.Nucleotide sequence, function, activation, and evolution of thecryptic asc operon of Escherichia coli K12Mol. Biol. Evol. 9 (4), 688-706 (1992)PubMed: 1630307","Mon Feb 27 13:28:26 2006","Tue Feb 5 13:59:38 2002","1","","","SMU.1102c","372" "SMu1008","1046293","1045895","399","ATGACAACCATTTATTTGATGAGACATGGTCAGACCTTATTCAATGCCCAAAAACGTATTCAGGGCTGGTCGGATTCCCCTTTGACAGAAGTGGGAATTGAGCAGGCTAAACAAGCTGGCAACTATCTCAGGAAATTGGGTTTGACTTTTGATAGTCTCTACTGTTCAACCGCTGAACGTGCCAGCGATACCCTAGAATTAGTAACAGGACGGACAGTATATAAACGTCTCAAGGGATTGAAAGAGATGAACTTTGGAGCTTATGAAGGTCAACAAGAATACCTACATCCACCGCGTACAGTTCGTCGGGAAACAGCTAATTACTATGAAAAATTTGGCGGTGAAACAGACAGAGCTGTTCAAGAGCGCTTATTAAAAACAATGACAGCTATTGCTTAA","10.00","4.43","15103","MTTIYLMRHGQTLFNAQKRIQGWSDSPLTEVGIEQAKQAGNYLRKLGLTFDSLYCSTAERASDTLELVTGRTVYKRLKGLKEMNFGAYEGQQEYLHPPRTVRRETANYYEKFGGETDRAVQERLLKTMTAIA","1045909","For other 'gpm' genes see SMu0067 (gpm); SMu0543 (gpmA); SMu0640 (gpmB); SMu1009 (gpm) and SMu1010 (gpm).","phosphoglycerate mutase-like protein","Cytoplasm","Matches weakly in gapped BLAST to phosphoglycerate mutase sequences.Residues 3-131 are 53% similar to the predicted enzyme from Listeria innocua (gi|16800277|). Residues 1-131 are 35% similar to the enzyme of Listeria monocytogenes EGD-e (gi|16802314|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0092 (1e-11).","

InterPro
IPR001345
Active_site

Phosphoglycerate/bisphosphoglycerate mutase
PS00175	$\"[6-15]T$	PG_MUTASE

InterPro
IPR013078
Domain

Phosphoglycerate mutase
PF00300	$\"[3-132]T$	PGAM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1240	$\"[2-132]T$	G3DSA:3.40.50.1240
PIRSF001490	$\"[2-132]T$	DPGAM
PTHR23029	$\"[2-132]T$	PTHR23029
SSF53254	$\"[1-132]T$	SSF53254

","BeTs to 4 clades of COG0588COG name: Phosphoglycerate mutase 1Functional Class: GThe phylogenetic pattern of COG0588 is ----Y---e-rh----olin-Number of proteins in this genome belonging to this COG is 2","***** IPB001345 (Phosphoglycerate mutase family) with a combined E-value of 5.2e-17. IPB001345A 4-33 IPB001345B 53-65 IPB001345C 72-103 IPB001345D 112-130","Residues 7-65 are 42% similar to a (MUTASE PROTEOME COMPLETE PHOSPHOGLYCERATE) protein domain (PD000730) which is seen in PMG1_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 12:29:45 2002","Tue Feb 5 15:01:13 2002","Tue Oct 15 12:28:11 2002","Tue Feb 5 15:00:07 2002","Tue Feb 5 15:00:07 2002","Tue Feb 5 15:00:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1008 is paralogously related (blast p-value < 1e-3) to SMu1009, SMu1010, SMu0067, SMu0640, and SMu0543, all of which have properties of phosphoglycerate mutase.","Tue Feb 5 15:00:07 2002","","No significant hits to the NCBI PDB database.","SMU.1104c","","Residues 2 to 131 (E-value = 1e-09) place SMu1008 in the PGAM family which is described as Phosphoglycerate mutase family (PF00300)","Tue Feb 5 15:00:07 2002","24379537","","","","","","1","","","SMU.1104c","" "SMu1009","1046904","1046290","615","ATGAGTAAACATTTTTATTTGATGCGGCATGGGCAAACACGCTTTAATGAGCAGCGCAGAATCCAAGGAGTTTGTGATTCACCCCTGACCGAACTTGGTATTAAACAAGCTCAACAAGCAGCAGACTATTTTAAAGATAAGGGAATTGTTTTTGAAGAAATCTATTCTTCCACACAAGAACGTGCCTGTGACACTGCGGAAATCGTTTCAGGACGAAAAGATATTATTCGCTTGAAAGGCTTGAAAGAATGGGATTTTGGAACTTTTGAAGGGCAACAGGAATATCTCAATCCTCCTTTGCAAGCTGGTGGTGTTGGTTATGGCGATTATTTTGTTGTCCATGGTGGTGAATCAAATCAAGACGTACGTGAGCGTATGGGAGAGACTGTTAGAGACTTGCTAGAAAACAGCTCTGCCAAAACCATTCTTGCTGTCAGTCACGGTGGCGCCATTGCTCAGTTTTTTCGTCATATTCTAGCTGATCCACCACAAATTCGCGGTATGCACAACTGTGCTATCTTGCATTTTTACTATGACAATGGTGAATTTGATCTTTTATCTATTTACAATCCAGATGATGCCAGTTTTGTTTATAGAAAGGGAGACCAAAGATGA","5.90","-4.45","23208","MSKHFYLMRHGQTRFNEQRRIQGVCDSPLTELGIKQAQQAADYFKDKGIVFEEIYSSTQERACDTAEIVSGRKDIIRLKGLKEWDFGTFEGQQEYLNPPLQAGGVGYGDYFVVHGGESNQDVRERMGETVRDLLENSSAKTILAVSHGGAIAQFFRHILADPPQIRGMHNCAILHFYYDNGEFDLLSIYNPDDASFVYRKGDQR","1046304","For other 'gpm' genes see SMu0067 (gpm); SMu0543 (gpmA); SMu0640 (gpmB); SMu1008 (gpm) and SMu1010 (gpm).","phosphoglycerate mutase-like protein","Cytoplasm","Limited matches in gapped BLAST to phosphoglycerate mutase sequences.Residues 1-192 are 51% similar to phosphoglycerate mutase 1 from Listeria innocua (gi|16800277|).Residues 6-188 are 31% similar to the phosphoglycerate mutase from Listeria monocytogenes EGD-e (gi|16802314|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0752 (4e-12).","

InterPro
IPR001345
Active_site

Phosphoglycerate/bisphosphoglycerate mutase
PS00175	$\"[7-16]T$	PG_MUTASE

InterPro
IPR013078
Domain

Phosphoglycerate mutase
PF00300	$\"[4-154]T$	PGAM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1240	$\"[1-194]T$	G3DSA:3.40.50.1240
PIRSF001490	$\"[3-204]T$	DPGAM
PTHR23029	$\"[5-194]T$	PTHR23029
SSF53254	$\"[1-197]T$	SSF53254

","BeTs to 7 clades of COG0406COG name: Phosphoglycerate mutase/fructose-2,6-bisphosphataseFunctional Class: GThe phylogenetic pattern of COG0406 is ----YQvCEbR----------Number of proteins in this genome belonging to this COG is 4","***** IPB001345 (Phosphoglycerate mutase family) with a combined E-value of 1.6e-16. IPB001345A 5-34 IPB001345B 54-66 IPB001345C 73-104 IPB001345D 114-132","Residues 8-87 are 45% similar to a (MUTASE PROTEOME COMPLETE PHOSPHOGLYCERATE) protein domain (PD000730) which is seen in PMG2_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 12:29:07 2002","Tue Feb 5 15:37:09 2002","Tue Oct 15 12:29:07 2002","Tue Feb 5 15:32:58 2002","Tue Feb 5 15:32:58 2002","Tue Feb 5 15:32:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1009 is paralogously related (blast p-value < 1e-3) to SMu1010, SMu1008, SMu0640, and SMu0067 all of which have properties of phosphoglycerate mutase.","Tue Feb 5 15:32:58 2002","","No significant hits to the NCBI PDB database.","SMU.1105c","","Residues 3 to 189 (E-value = 5.1e-14) place SMu1009 in the PGAM family which is described as Phosphoglycerate mutase family (PF00300)","Tue Feb 5 15:32:58 2002","24379538","","","","","","1","","","SMU.1105c","" "SMu1010","1047512","1046916","597","ATGGTTCAAACGCTATATCTTATGCGCCATGGAGAAACCTTATTTAACACACAAAAGCGCGTTCAAGGGTGGTGTGATTCTCCCTTGACTGATCTGGGAATTACTCAAGCAAAATTAGTGAGAGATTATTTTCAAGAAAAAGGAATTACTTTTGATAAGGTCTATTCCTCAACACAGGAGCGGGCGACAGATACTTTGAAATTGATTACAAATCAATCTTATCAACAGTTGAAGGGATTGAAAGAAATGAATTTCGGGATTTTTGAAGCTCAACCAGAAAGCTTGCTGCCTCGTTTTAGACCTGGTTCGTCTTCTTTTGAAGACTTACTGGTTCCTTATGGTGGTGAAGATATTGCTCAAGTGGGTAAACGTATTTATGAAACAATTCTTACAACTTTGAAAAAACAGTCAGCCCAAACGCTGTTGATGGTCAGTCATGGTGCAGCATTATATGGATTGATACTTGAATTGAACATTCAATTGCCTCAGGATCTTCGTTTTGGAAATTGTGCTATTTGCAAGTACCAGTATGAGAATGGTCATCTGAACTTGCTTAGTGTTATTGATCCCTTGAAAAATATTTCTTTTGATATTTAG","6.80","-0.42","22490","MVQTLYLMRHGETLFNTQKRVQGWCDSPLTDLGITQAKLVRDYFQEKGITFDKVYSSTQERATDTLKLITNQSYQQLKGLKEMNFGIFEAQPESLLPRFRPGSSSFEDLLVPYGGEDIAQVGKRIYETILTTLKKQSAQTLLMVSHGAALYGLILELNIQLPQDLRFGNCAICKYQYENGHLNLLSVIDPLKNISFDI","1046930","For other 'gpm' genes see SMu0067 (gpm); SMu0543 (gpmA); SMu0640 (gpmB); SMu1008 (gpm) and SMu1009 (gpm).","phosphoglycerate mutase-like protein","Cytoplasm","Limited matches in gapped BLAST to phosphoglycerate mutase 1sequences.Residues 1-189 are 48% similar to the enzyme from Listeria innocua (gi|16800277|) and are 47% similar to the protein from Listeria monocytogenes EGD-e (gi|16803284|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0092 (7e-13).","

InterPro
IPR001345
Active_site

Phosphoglycerate/bisphosphoglycerate mutase
PS00175	$\"[7-16]T$	PG_MUTASE

InterPro
IPR013078
Domain

Phosphoglycerate mutase
PF00300	$\"[4-153]T$	PGAM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1240	$\"[1-180]T$	G3DSA:3.40.50.1240
PIRSF001490	$\"[3-193]T$	DPGAM
PTHR23029	$\"[3-198]T$	PTHR23029
SSF53254	$\"[1-182]T$	SSF53254

","BeTs to 7 clades of COG0406COG name: Phosphoglycerate mutase/fructose-2,6-bisphosphataseFunctional Class: GThe phylogenetic pattern of COG0406 is ----YQvCEbR----------Number of proteins in this genome belonging to this COG is 4","***** IPB001345 (Phosphoglycerate mutase family) with a combined E-value of 4.7e-16. IPB001345A 5-34 IPB001345B 54-66 IPB001345C 72-103 IPB001345D 113-131","Residues 8-86 are 41% similar to a (MUTASE PROTEOME COMPLETE PHOSPHOGLYCERATE PGAM) protein domain (PD000730) which is seen in Q9CGZ3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 12:30:27 2002","Tue Feb 5 15:45:56 2002","Tue Oct 15 12:30:27 2002","Tue Feb 5 15:45:56 2002","Tue Feb 5 15:45:56 2002","Tue Feb 5 15:45:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1010 is paralogously related (blast p-value < 1e-3) to SMu1009, SMu1008, SMu0640, SMu0067, and SMu0543, all of which have properties of phosphoglycerate mutase.","Tue Feb 5 15:48:39 2002","","No significant hits to the NCBI PDB database.","SMU.1106c","","Residues 3 to 185 (E-value = 6.7e-14) place SMu1010 in the PGAM family which is described as Phosphoglycerate mutase family (PF00300)","Tue Feb 5 15:45:56 2002","24379539","","","","","","1","","","SMU.1106c","" "SMu1011","1048644","1048069","576","ATGAAACGGCTGCAAACTTTTCAGAAAGCCAACAGTAAGGTTAAAGCGGATAGTATCGTATTTGCAGGAGATTCCATCACTGAGTTTTTCCCTTTGAAAAAATATCTAGGTCATGATTTGCCTTTAGTCAATAGAGGAATAGCTGGGACAGATTCTGTTTGGCTTTTGGAACATATAGAAGATCAAGTGTTGACTTTGAGTCCTGCTAAAGTTTTCTTGATGATTGGCATTAATGATATCGGTAGAGGTTATCCTCTGTCAGACATTGTCGCAAGGATCTCGAATATCATTGCTCAAATTAGAGCTAATCATATTTTGACAAAGATTTATGTATTGTCTGTATTACCAGTCAATGAATCTGATCAGTATGCTGGTAAGGTAAAAATCAGAAATAATGCACTTATTCAGGTGTTAAATCATCATTTACAGGTTTTATCTGGGGTTAACTATATTGATTTATATCCATTATTGTTAGATGAAAAAGGAGAATTAGCTGAGGATTATACGACGGACGGACTGCATTTGACTCAAACAGCCTATGATAAAATTGCTCAAACCATAAAAACAGACTTATAA","6.80","-0.56","21325","MKRLQTFQKANSKVKADSIVFAGDSITEFFPLKKYLGHDLPLVNRGIAGTDSVWLLEHIEDQVLTLSPAKVFLMIGINDIGRGYPLSDIVARISNIIAQIRANHILTKIYVLSVLPVNESDQYAGKVKIRNNALIQVLNHHLQVLSGVNYIDLYPLLLDEKGELAEDYTTDGLHLTQTAYDKIAQTIKTDL","1048083","","conserved hypothetical protein","Cytoplasm, Membrane","Several matches in gapped BLAST to hypothetical protein: residues 2-189 are 47% similar to the enzyme in S.pyogenes (gi|13622253|). Residues 4-191 are 30% similar to the protein from Lactococcus lactis (gi|15672692|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1104 (5e-61).","

InterPro
IPR001087
Family

Lipolytic enzyme, G-D-S-L
PF00657	$\"[19-187]T$	Lipase_GDSL

InterPro
IPR013830
Domain

Esterase, SGNH hydrolase-type
SSF52266	$\"[1-191]T$	Esterase_SGNH_hydro-type

InterPro
IPR013831
Domain

Esterase, SGNH hydrolase-type, subgroup
G3DSA:3.40.50.1110	$\"[10-188]T$	Esterase_SGNH_hydro-type_subgr

noIPR
unintegrated

unintegrated
PTHR11852	$\"[10-187]T$	PTHR11852

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-191 are 30% similar to a (PROTEOME COMPLETE YHBF) protein domain (PD400618) which is seen in Q9CHL9_LACLA.Residues 8-180 are 30% similar to a (SYNTHETASE ACID CYTIDYLYLTRANSFERASE) protein domain (PD114699) which is seen in NEUA_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 6 08:13:14 2002","Wed Feb 6 08:13:14 2002","Wed Feb 6 08:13:14 2002","Wed Feb 6 08:13:14 2002","","Wed Feb 6 08:13:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1011 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 6 08:13:14 2002","","No significant hits to the NCBI PDB database.","SMU.1107c","","Residues 19 to 187 (E-value = 3.2e-15) place SMu1011 in the Lipase_GDSL family which is described as GDSL-like Lipase/Acylhydrolase (PF00657)","Wed Feb 6 08:13:14 2002","24379540","","","","","","1","","","SMU.1107c","811" "SMu1012","1049588","1048776","813","ATGAGTGTGAAAGTTATTGCAACCGATATGGATGGAACCTTCTTAAATTCTAAAGGGAGTTACGATCATAACCGATTTCAGAGAATCTTAAAACAACTGCAAGAAAGAGATATTCGCTTTGTTGTCGCAAGCAGCAATCCATACCGTCAATTGCGCGAACACTTTCCTGATTGTCATGAGCAGTTAACTTTTGTCGGTGAAAATGGTGCTAATATTATTTCTAAAAATCAATCCTTGATTGAAGTTTTCCAGCAAAGAGAGGATATCGCCAGTATCATTTACTTTATTGAAGAGAAGTATCCTCAAGCTGTTATTGCCTTATCGGGAGAAAAGAAAGGCTATCTAAAAAAGGGCGTTTCTGAGAATATTGTCAAAATGCTTTCACCTTTCTTTCCTGTTTTAGAACTTGTGAACTCGTTTTCCCCTCTTCCTGATGAACGCTTTTTTAAGTTGACCCTGCAGGTCAAAGAAGAGGAGTCAGCTCAGATCATGAAGGCTATTGCTGATTATAAAACAAGTCAGCGTTTGGTAGGAACGGCCAGCGGTTTTGGTTATATTGATATTATTACAAAAGGACTGCACAAGGGATGGGCTTTACAGCAGTTATTGAAACGCTGGAATTTTACTAGTGATCATTTAATGGCTTTTGGTGATGGCGGAAATGATATTGAAATGCTAAAACTAGCTAAGTATTCTTATGCTATGGCTAATGCACCTAAAAATGTTAAGGCAGCTGCTAATTATCAAGCTAAGTCAAATGATGAATCTGGAGTCTTAGACGTTATTGATAATTATCTGGCTTCTATTGATTAG","7.10","0.17","30523","MSVKVIATDMDGTFLNSKGSYDHNRFQRILKQLQERDIRFVVASSNPYRQLREHFPDCHEQLTFVGENGANIISKNQSLIEVFQQREDIASIIYFIEEKYPQAVIALSGEKKGYLKKGVSENIVKMLSPFFPVLELVNSFSPLPDERFFKLTLQVKEEESAQIMKAIADYKTSQRLVGTASGFGYIDIITKGLHKGWALQQLLKRWNFTSDHLMAFGDGGNDIEMLKLAKYSYAMANAPKNVKAAANYQAKSNDESGVLDVIDNYLASID","1048790","","hydrolase","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 3-266 are 37% similar to Listeria innocua (gi16799517) and residues 1-266 are 37% similar to Salmonella enterica (gi16759777).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1105 (2e-50).","

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[5-262]T$	Cof-subfamily
PS01229	$\"[216-238]T$	COF_2

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[5-235]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[6-262]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[1-266]T$	G3DSA:3.40.50.1000
SSF56784	$\"[1-266]T$	SSF56784

","BeTs to 11 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","***** IPB000150 (Cof protein) with a combined E-value of 2.1e-24. IPB000150A 2-16 IPB000150B 37-46 IPB000150C 214-246","Residues 2-158 are 32% similar to a (YBJI PROTEOME COMPLETE OMPX-MOEB) protein domain (PD034657) which is seen in YBJI_ECOLI.Residues 189-249 are 37% similar to a (PROTEOME COMPLETE HYDROLASE ATPASE) protein domain (PD001342) which is seen in YBJI_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 6 08:36:46 2002","Tue Mar 27 13:19:40 2007","Tue Mar 27 13:19:40 2007","Wed Feb 6 08:32:19 2002","Wed Feb 6 08:32:19 2002","Wed Feb 6 08:32:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1012 is paralogously related (blast p-value < 1e-3) to SMu0674, SMu0388, SMu0461, SMu0367, SMu0675, SMu0655, SMu1666, and SMu0442, all predicted conserved hypothetical proteins.","Wed Feb 6 08:36:46 2002","","No significant hits to the NCBI PDB database.","SMU.1108c","","Residues 3 to 239 (E-value = 6.5e-07) place SMu1012 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Wed Feb 6 08:32:19 2002","24379541","","","","","","1","","","SMU.1108c","" "SMu1013","1051056","1049803","1254","ATGGCGGAAGAGGAACGCTCAACATGGAAAAGCAAATTTAAAGCTATGGGACCGGGGATCCTTATGGCATCAGCAGCTGTTGGTGGATCCCATATTGTATCATCAACGCAAGCAGGCGCTATTTACGGCTGGCAGTTGGCCATTATTGTTTTATTGGTTAACTTGTTTAAATATCCATTTTTTCGTTTTGGCTCGCAATACACACTGCAAAATAATAAAAGTCTGATTGAAGGCTACAAAGAAAAAGGGAAACTTTATTTGTGGGTATTTTTTATCATGAATATATTCTCAGCCGTTGTCAATACAGCAGCTGTTGGAATTTTAGCTGCGGCAATTCTTTATAATATCTTCCCGAATGGATTTGGCCTGTCTATCTCGCAATTAACAACAGCCCTTATCATAGTAACCTTGGCAATGCTTTTAATTGGAGGTTATCGTTTTCTTGATGGCTTGTCTAAGTGGGTGATGACAGCCTTGACTTTGGCGACAACCTTGGCTGTTGTTATTGCTCTCTTTAAACATAGAGAATATGCTCCAGATTTCACAGCATCATCACCGTGGCAACTAACAGCCCTGCCTTTTATTGTTTCTTTGATGGGCTGGATGCCAGCTCCGATTGAAATTTCGGCTATCAATTCTATGTGGACGGTTGAAAAGCGCAAGACAGCAAAAGTTTCTCTGACTGATGGTATTTTTGACTTTAACGTTGGTTATATCGGAACAGCGGTTCTTGCATTTATCTTCTTGGCACTGGGTGCTTTGATTCAATTTGGTTCAGGCCAACAAGTTAAGAGTGCTAGTGCAGCTTACATTGCCCAGTTTATCAATATGTATGAATCGTCCTTTGGTGCTTGGTCTCGTCTTTTGATTGCCTTCATTGCCTTTTTGTGCATCTTTGGTACAACCATTACAGTTATTGATGGCTATTCGCGTGCCAATAATGAAACCATGCGCTTACTGTTTGGACGAAAGGAAGCTTCACAAAAGGTGCTTAATGTTTGGATGGTCTTTACATCTATTATTGGGATTATTATTGTTCTTTTATTTGCAGGTGATGTTGCAACTCTAATGCGCTTTGCTATGATTGCGTCTTTCCTGACAACGCCAGTTTATGCTTATTTGAATTATTCATTGGTTAATAACAAGGAGCACAAGCTATCTGTTTGGCTGAATTGGTTATCAATTTTTGGTTTGATTTATCTGGCTGGTTTTGCTATTTTCTTCCTGGTTTATATAACTGGTCTACTCAGCTAA","10.30","10.67","46009","MAEEERSTWKSKFKAMGPGILMASAAVGGSHIVSSTQAGAIYGWQLAIIVLLVNLFKYPFFRFGSQYTLQNNKSLIEGYKEKGKLYLWVFFIMNIFSAVVNTAAVGILAAAILYNIFPNGFGLSISQLTTALIIVTLAMLLIGGYRFLDGLSKWVMTALTLATTLAVVIALFKHREYAPDFTASSPWQLTALPFIVSLMGWMPAPIEISAINSMWTVEKRKTAKVSLTDGIFDFNVGYIGTAVLAFIFLALGALIQFGSGQQVKSASAAYIAQFINMYESSFGAWSRLLIAFIAFLCIFGTTITVIDGYSRANNETMRLLFGRKEASQKVLNVWMVFTSIIGIIIVLLFAGDVATLMRFAMIASFLTTPVYAYLNYSLVNNKEHKLSVWLNWLSIFGLIYLAGFAIFFLVYITGLLS","1049817","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein and possible Mn transporter, NRAMR family: residues 6-409 are 59%similar to the protein in S.pneumoniae (gi|15900097|). Residues 13-238 are 23% similar to Mn transporter, NRAMR family from Clostridium acetobutylicum (gi|15893916|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0745 (0.001).","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[66-252]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[15-35]?$ $\"[41-61]?$ $\"[85-114]?$ $\"[124-144]?$ $\"[154-172]?$ $\"[191-213]?$ $\"[234-254]?$ $\"[289-309]?$ $\"[330-350]?$ $\"[356-374]?$ $\"[389-411]?$	transmembrane_regions

","BeTs to 3 clades of COG1914COG name: Putative Mn transporter, NRAMP familyFunctional Class: PThe phylogenetic pattern of COG1914 is ----Y---ebr----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 7-414 are 54% similar to a (MANGANESE MEMBRANE TRANSPORT PROTEOME) protein domain (PD322908) which is seen in MNTH_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 6 08:49:05 2002","Wed Feb 6 08:49:05 2002","Wed Feb 6 08:48:22 2002","Wed Feb 6 08:48:22 2002","","Wed Feb 6 08:48:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1013 is paralogously related (blast p-value < 1e-3) to SMu0698, a predicted manganese transporter.","Wed Feb 6 08:50:10 2002","","No significant hits to the NCBI PDB database.","SMU.1109c","","No significant hits to the Pfam 11.0 database","Wed Feb 6 08:48:22 2002","24379542","","","","","","1","","","SMU.1109c","" "SMu1014","1052172","1051336","837","ATGGGGTATTCTTTAAGTGAAGAGCAGCGCAGCCAAACATTGAATTTGTTGGGTTATAGTGCTGATAAGGATACCAATGTTAAAACACTAAATACAAGCAGCTATGCTAAAATTATGAATGTTGCTGATGATCCGAGTTTGCAGTTATATTCATCTGTTAAGATTCAAAAATTAGGTAATAAGGAAACACTTGATGTGCAGATTGTTACTCCTGAAAACATCACGAAAGTGACACAGGATATGTATCGAAATGCCGCTGTAACGCTTGGAATTGAACATGCTAAAATTACAGTTGCAGCACCAATTGCTGTAACGGGAGAATCAGCTTTAGCGGGTATTTATTACTCACTTGAAGAAAATGGTGCAAGCGTTTCTGAAGAAAGTAAAAATTTGGCTCAAGAAGAACTCAATACTCTCTCTGGAATTAATGAGGAAAATAAAGGAAAAGAAAGTTATGATGCTGATAAGCTTAATGTTGCTCTAACAGATATTAAATCTGCAGTGGCTGATTCAGGTGATAAATTAACAAAAGATCAAGTTCGAAAGATTGTTGAGAATACGTTGAAAAATTACAATTTAAATTCTTCAATGACTGACAAACAAATAACATTAATCGTTAATTTTGCATTTAAACTTTCAAAGAGTGAGGTTATTCACAATAAAGGGTTTAAATCAACTTTGAATTCTCTAAAAGACAGTATTGTTGCTAATGCTAAATCAACTTTTAAGGGACTCAACTTAAAGTTTAATGCTAACAAAGCTATTGAGTCCGGTAAAGGTTTTTTTGCTAAAATCTGGCAATGGCTTGTTAATTTTTTTACAGGATTATTTTCCTAA","7.70","0.49","30489","MGYSLSEEQRSQTLNLLGYSADKDTNVKTLNTSSYAKIMNVADDPSLQLYSSVKIQKLGNKETLDVQIVTPENITKVTQDMYRNAAVTLGIEHAKITVAAPIAVTGESALAGIYYSLEENGASVSEESKNLAQEELNTLSGINEENKGKESYDADKLNVALTDIKSAVADSGDKLTKDQVRKIVENTLKNYNLNSSMTDKQITLIVNFAFKLSKSEVIHNKGFKSTLNSLKDSIVANAKSTFKGLNLKFNANKAIESGKGFFAKIWQWLVNFFTGLFS","1051350","","conserved hypothetical protein","Membrane, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins:residues 1-273 are 63% similar to S.pneumoniae (gi|15900898|) and 27% similar to B.subtilis (gi|16079394|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0963 (1e-112).","

InterPro
IPR009343
Family

Protein of unknown function DUF1002
PF06207	$\"[1-231]T$	DUF1002

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-271 are 27% similar to a (PROTEOME COMPLETE ORFX19 LYSA-PPIB) protein domain (PD040180) which is seen in YPUA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 6 08:53:59 2002","Wed Feb 6 08:53:59 2002","Wed Feb 6 08:53:59 2002","Wed Feb 6 08:53:59 2002","","Wed Feb 6 08:53:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1014 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 6 08:53:59 2002","","No significant hits to the NCBI PDB database.","SMU.1111c","","Residues 1 to 231 (E-value = 8e-123) place SMu1014 in the DUF1002 family which is described as Protein of unknown function (DUF1002) (PF06207)","Wed Feb 6 08:53:59 2002","24379543","","","","","","1","","","SMU.1111c","348" "SMu1015","1052796","1052392","405","ATGAAATTAAAAGCAGTTCATCATGTTGCTTTGATAGTTTCGGATTATGATAAATCTTATGAGTTTTATGTTAATCAATTGGGTTTTGAAGTCATTCGAGAAAATCACAGGCCGAAACGTCATGATTACAAACTTGATTTGAAATGTGGTGATATTGAGTTAGAAATTTTTGGAAATAAGTTAACGGACTCTAATTACTGCGCCCCACCAGAGCGTATCAGTTGGCCGCGAGAAGCTTGTGGCTTGAGACATCTAGCTTTTTATGTAGAAGATGTTGAGGCATCTAGGCAAGAGTTGATAGCTTTAGGTATAAGAGTTGAAGAGGTTCGTTATGATGATTATACAGGTAAAAAAATGGCTTTCTTTTTTGATCCAGATGGTCTGCCTTTGGAATTACATGAATAG","5.40","-5.70","15720","MKLKAVHHVALIVSDYDKSYEFYVNQLGFEVIRENHRPKRHDYKLDLKCGDIELEIFGNKLTDSNYCAPPERISWPREACGLRHLAFYVEDVEASRQELIALGIRVEEVRYDDYTGKKMAFFFDPDGLPLELHE","1052406","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypotheticals and to Glyoxalase I: residues 1-134 are 67% similar to the protein in S.pyogenes (gi|15675131|) and are 55% similar to the protein from Clostridium acetobutylicum (gi|15893541|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0962 (1e-61).","

InterPro
IPR004360
Domain

Glyoxalase/bleomycin resistance protein/dioxygenase
PF00903	$\"[5-132]T$	Glyoxalase

InterPro
IPR004361
Family

Glyoxalase I
PS00934	$\"[8-29]?$	GLYOXALASE_I_1

InterPro
IPR011588
Domain

Glyoxalase/extradiol ring-cleavage dioxygenase
PD002334	$\"[8-134]T$	Gly_diox

noIPR
unintegrated

unintegrated
G3DSA:3.10.180.10	$\"[6-134]T$	G3DSA:3.10.180.10
PTHR10374	$\"[1-132]T$	PTHR10374
SSF54593	$\"[1-134]T$	SSF54593

","BeTs to 8 clades of COG0346COG name: Lactoylglutathione lyaseFunctional Class: EThe phylogenetic pattern of COG0346 is A-tky--CEBRh---------Number of proteins in this genome belonging to this COG is 2","***** IPB000325 (Glyoxalase I) with a combined E-value of 3.6e-13. IPB000325A 8-46 IPB000325C 80-114 IPB000325D 119-131 IPB000325C 4-38","Residues 6-134 are 50% similar to a (COMPLETE PROTEOME I PM0014) protein domain (PD021040) which is seen in Q9CIM1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 6 09:06:31 2002","Wed Feb 6 09:03:30 2002","Wed Feb 6 09:03:30 2002","Wed Feb 6 09:03:30 2002","Wed Feb 6 09:03:30 2002","Wed Feb 6 09:03:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1015 is paralogously related (blast p-value < 1e-3) to SMu1458, a predicted lactoylglutathione lyase.","Wed Feb 6 09:06:31 2002","","No significant hits to the NCBI PDB database.","SMU.1112c","","Residues 5 to 132 (E-value = 3e-20) place SMu1015 in the Glyoxalase family which is described as Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily (PF00903)","Wed Feb 6 09:03:30 2002","24379544","","","","","","1","","","SMU.1112c","928" "SMu1016","1053754","1053014","741","ATGAAAAAAGAACGTCAATCTAGGAAAAAACGAAGTTTTTTAAGGACCTTTCTGCCTATCCTTTTATTAGTGATTGGTTTAGCACTAATCTTCAATACTCCAATTAGAAATGCCCTAATTGCTTGGAATACCAATAGATATCAGGTTTCTAATGTTAGCAAGAAAGATATTGAACACAACAAGGCTGCCCATTCTTCCTTTGATTTTAAAAAGGTGGAATCCATCAGTACTCAATCGGTACTGGCAGCACAAATGGCTGCTCAGAAGCTTCCTGTAATTGGCGGAATTGCCATTCCAGACTTAAAAATCAACTTACCAATCTTCAAAGGATTAGATAATGTTGGCTTAACATATGGTGCTGGAACGATGAAAAATGACCAAGTCATGGGAGAAAATAATTATGCTCTTGCTAGCCATCATGTTTTTGGTATGACCGGATCTTCACAGATGCTCTTTTCACCTTTAGAACGTGCAAAAGAAGGCATGGAAATTTATCTGACTGATAAAAATAAGGTTTATACTTATGTTATTAGTGAAGTGAAAACTGTCACACCTGAACATGTAGAAGTTATTGACAATCGGCCGGGACAAAATGAAGTTACTTTGGTCACTTGTACAGATGCGGGGGCGACTGCCAGAACAATTGTTCATGGCACATATAAGGGGGAAAATGATTTTAATAAGACTTCCAAAAAGATAAAAAAAGCTTTTAGGCAGTCCTATAATCAAATATCATTTTAA","10.50","13.39","27458","MKKERQSRKKRSFLRTFLPILLLVIGLALIFNTPIRNALIAWNTNRYQVSNVSKKDIEHNKAAHSSFDFKKVESISTQSVLAAQMAAQKLPVIGGIAIPDLKINLPIFKGLDNVGLTYGAGTMKNDQVMGENNYALASHHVFGMTGSSQMLFSPLERAKEGMEIYLTDKNKVYTYVISEVKTVTPEHVEVIDNRPGQNEVTLVTCTDAGATARTIVHGTYKGENDFNKTSKKIKKAFRQSYNQISF","1053028","","sortase","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to hypotheticals and to sortase: residues 2-245 are 62% similar to the hypothetical protein in S.pyogenes (gi15675130).Residues 2-243 are 56% similar to sortase from S.pneumoniae (gi15903141).See GI:47077914.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0961 (2e-78).","

InterPro
IPR005754
Family

Peptidase C60, sortase A and B
PF04203	$\"[96-221]T$	Sortase
TIGR01076	$\"[94-226]T$	sortase_fam

noIPR
unintegrated

unintegrated
G3DSA:2.40.260.10	$\"[82-227]T$	G3DSA:2.40.260.10
SSF63817	$\"[25-222]T$	SSF63817

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-122 are 52% similar to a (PROTEOME COMPLETE SORTASE YLCC) protein domain (PD415145) which is seen in Q9F0P0_STRGN.Residues 123-218 are 67% similar to a (PROTEOME COMPLETE SORTASE MEMBRANE) protein domain (PD068544) which is seen in Q9F0P0_STRGN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 6 09:12:22 2002","Tue Oct 15 12:32:41 2002","Tue Feb 1 12:03:00 2005","Wed Feb 6 09:11:25 2002","","Wed Feb 6 09:11:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1016 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 6 09:12:22 2002","","No significant hits to the NCBI PDB database.","SMU.1113c","","Residues 96 to 221 (E-value = 2.4e-51) place SMu1016 in the Sortase family which is described as Sortase family (PF04203)","Wed Feb 6 09:11:25 2002","","","Lee SF, McGavin MK.Identification of a point mutation resulting in loss of cell wall anchoring activity of SrtA of Streptococcus mutans NG5.Infect Immun. 2004 Jul;72(7):4314-7.PMID: 15213182Lvesque CM, Voronejskaia E, Huang YC, Mair RW, Ellen RP, Cvitkovitch DG.Involvement of sortase anchoring of cell wall proteins in biofilm formation by Streptococcus mutans.Infect Immun. 2005 Jun;73(6):3773-7.PMID: 15908410","Bolken,T.C., Franke,C.A., Jones,K.F., Zeller,G.O., Jones,C.H.,Dutton,E.K. and Hruby,D.E.Inactivation of the srtA gene in Streptococcus gordonii inhibitscell wall anchoring of surface proteins and decreases in vitro andin vivo adhesionInfect. Immun. 69 (1), 75-80 (2001)PubMed: 11119491Osaki M, Takamatsu D, Shimoji Y, Sekizaki T. Characterization of Streptococcus suis genes encoding proteins homologous tosortase of gram-positive bacteria.J Bacteriol. 2002 Feb;184(4):971-82.PMID: 11807057 ","Mon Jul 10 14:58:37 2006","Sat Oct 26 16:48:11 2002","1","","","SMU.1113c","798" "SMu1017","1056238","1053761","2478","ATGAGGCATTTTTTAATGCAAGATAGAAATTTAGTAGATGTCAATTTAACAAGTGAAATGAAGACGAGTTTTATTGACTATGCTATGAGTGTTATTGTTGCTCGGGCTCTTCCAGATGTTCGCGATGGATTAAAACCTGTTCATCGTCGTATTTTATATGGCATGAATGAATTGGGGGTTACTCCTGACAAGCCGCATAAAAAATCAGCGCGTATTACAGGTGATGTCATGGGTAAATACCATCCGCATGGAGATTCATCTATTTACGAAGCCATGGTTCGGATGGCACAATGGTGGTCTTACCGTCACATGTTGGTTGATGGTCATGGAAATTTTGGTTCTATGGACGGAGATGGCGCTGCAGCGCAGCGTTATACAGAAGCGCGTATGAGCAAAATTGCTATGGAAATGCTTCGTGATATTAATAAAAATACAGTTGATTTTGCAGATAACTATGATGGTTCTGAACGTGAACCTTTAGTTTTACCGTCACGTTTTCCAAATCTTCTGGTTAATGGAGCGACAGGTATTGCTGTTGGAATGGCCACTAATATTCCACCTCATAATTTGGGAGAAACAATTGATGCGGTCAAATTAGTTATGGATAATCCTGACGTGACAACGCGTGACCTAATGGAAGTACTACCCGGCCCCGATTTTCCAACAGGAGCTCTTGTCATGGGAAAATCGGGTATACATCGCGCCTATGATACAGGAAAGGGTTCTATTGTTTTGCGTGCTCGCACTGAGATTGAGCAAACGAAGTCAGGACGTGAACGCATTGTTGTTACTGAATTTCCTTATATGGTCAATAAAACTAAAGTACATGAGCATATTGTTCGCTTAGCACAAGAAAAACGCATTGAAGGTATCACTGCTGTTCGAGATGAATCCAGCCGTGAAGGCGTTCGTTTTATTATTGAAGTCCGCCGTGATGCTAGTGCTAATGTTATTTTAAATAATCTTTTTAAGTTAACAAGTCTACAAACTAATTTTAGTTTTAACATGTTAGCTATTGAGAAGGGTGTCCCTAAAATTTTGTCCTTGAGACAGATTTTAGATAATTATATTGACCATCAAAAAGAAGTCATTGTTAGACGTACTAAGTTTGATAAGGCTAAAGCTGAAAGCCGGGCTCATATCTTAGAAGGTTTACTGATTGCTCTTGATCATCTGGATGAAGTTATTACCATTATCCGCAATAGTGAGACAGATACCATTGCTCAAGCTGAATTAATGAGTCGTTTTGATTTATCCGAAAGACAAAGTCAAGCCATTCTTGATATGCGCCTGCGTCGCTTGACCGGCTTGGAACGTGATAAAATTCAGTCAGAATATAATGACCTTTTAGCATTGATCGCTGATTTAGCTGATATTTTGGCTAAACCAGAACGTGTTATCACAATCATCAAGGATGAACTTGAAGATATCAAACGCAAATTTGCTGATCAACGCCGAACAGAATTAATGGTTGGTGAAGTCCTGTCACTCGAAGATGAAGACTTGATTGAAGAAGAAGATGTTCTGATTACTTTATCTAATAAGGGTTATATTAAACGTCTTGGTCAAGATGAGTTTCGTACACAAAAACGAGGCGGTCGTGGTGTCCAAGGAACAGGCGTCAATGATGATGACTTTGTTCGTGAACTGGTATCAACAAGTACGCATGATGCCATGCTCTTCTTTACTAATCAAGGGAGAGTTTATCGTCTCAAAGGTTATGAAATTCCTGAATACGGCCGAACTGCAAAGGGCTTACCTATCGTCAATTTACTGAAATTAGATGATGGTGAAACGATTCAAACCATAATCAATGTGAAATCAGATGATTTTCATGATAAGTATTTATTCTTTACGACTAGACAAGGAGTTGTCAAACGGACTAGTGTGTCTGCCTTTGGCAATATTCGTCAAAATGGTCTCAAAGCGCTGAGTCTGCGCGATAATGATGAATTGATCAACGTTCTTTTGACCAATGGTCAAGAGGATATCATTATTGGAACACATTTAGGTTATTCTGTTCGTTTCCAAGAATCTGCTGTCCGCAATATGGGACGTTTGGCAACTGGTGTGAAAGGTGTTAATCTCAGGAAAAATGATTATGTCATTGGTGCAGATCACATAGCAGATAGTCGCAATGTTTTAACCATTACAGAAAAAGGGTATGGTAAGCAAACACCTGCCAGTGAATACCCGACTAAAGGACGTGGTGGTAAAGGAATTAAAACTGCCAATATCACCGCTAAAAATGGTCCTCTCGCTGGACTTGTCACTGTCAATGATGATGAAGATATCATGATTATTACGGATACTGGTGTTATCATTCGTACAAGTGTTGCCGATATCTCTCAGACTGGGCGTTCAGCTATGGGTGTCAAAGTGATGCGCCTAGATGAAAATGCTAAGATTGTAACCTTTGCTTTGGTCAAGTCTGAAGTAATAGAAGGCACTTCACTAAATAATAATGAAAATGAGTAG","6.70","-2.56","92338","MRHFLMQDRNLVDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIAMEMLRDINKNTVDFADNYDGSEREPLVLPSRFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPDVTTRDLMEVLPGPDFPTGALVMGKSGIHRAYDTGKGSIVLRARTEIEQTKSGRERIVVTEFPYMVNKTKVHEHIVRLAQEKRIEGITAVRDESSREGVRFIIEVRRDASANVILNNLFKLTSLQTNFSFNMLAIEKGVPKILSLRQILDNYIDHQKEVIVRRTKFDKAKAESRAHILEGLLIALDHLDEVITIIRNSETDTIAQAELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYNDLLALIADLADILAKPERVITIIKDELEDIKRKFADQRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLGQDEFRTQKRGGRGVQGTGVNDDDFVRELVSTSTHDAMLFFTNQGRVYRLKGYEIPEYGRTAKGLPIVNLLKLDDGETIQTIINVKSDDFHDKYLFFTTRQGVVKRTSVSAFGNIRQNGLKALSLRDNDELINVLLTNGQEDIIIGTHLGYSVRFQESAVRNMGRLATGVKGVNLRKNDYVIGADHIADSRNVLTITEKGYGKQTPASEYPTKGRGGKGIKTANITAKNGPLAGLVTVNDDEDIMIITDTGVIIRTSVADISQTGRSAMGVKVMRLDENAKIVTFALVKSEVIEGTSLNNNENE","1053775","For other 'gyr' genes see SMu1167 (gyrB). For DNA gyrase B subunit see SMu1167.","DNA gyrase A subunit","Cytoplasm","Several matches in gapped BLAST to DNA gyrase A subunit : residues 6-812 are 80% similar to the enzyme in S.pyogenes (gi15675129). Residues 6-821 are also 80% similar to the protein from S.pneumoniae (gi9230555).This sequence corresponds to AY462103, a mutant sequence in GenBank.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0960 (0.0).","

InterPro
IPR002110
Repeat

Ankyrin
PR01415	$\"[228-240]T$ $\"[649-661]T$	ANKYRIN

InterPro
IPR002205
Domain

DNA topoisomerase, type IIA, subunit A or C-terminal
PD000742	$\"[50-125]T$	DNA_topoisoIV
PF00521	$\"[35-482]T$	DNA_topoisoIV
SM00434	$\"[14-467]T$	TOP4c

InterPro
IPR005743
Family

DNA gyrase, subunit A
TIGR01063	$\"[11-811]T$	gyrA

InterPro
IPR006691
Repeat

DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel
PF03989	$\"[506-555]T$ $\"[556-608]T$ $\"[613-660]T$ $\"[661-710]T$ $\"[711-761]T$ $\"[762-811]T$	DNA_gyraseA_C

InterPro
IPR013757
Domain

DNA topoisomerase, type IIA, subunit A, alpha-helical
G3DSA:1.10.268.10	$\"[372-461]T$	Topo_IIA_A_a

InterPro
IPR013758
Domain

DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta
G3DSA:3.90.199.10	$\"[33-299]T$	Topo_IIA_A/C_ab

InterPro
IPR013760
Domain

DNA topoisomerase, type IIA, central
SSF56719	$\"[33-490]T$	Topo_IIA_cen

noIPR
unintegrated

unintegrated
PTHR10169	$\"[35-202]T$	PTHR10169
PTHR10169:SF2	$\"[35-202]T$	PTHR10169:SF2
SSF101904	$\"[506-809]T$	SSF101904

","BeTs to 14 clades of COG0188COG name: DNA gyrase (topoisomerase II) A subunitFunctional Class: LThe phylogenetic pattern of COG0188 is a---yqvCEBrHujGPOlINXNumber of proteins in this genome belonging to this COG is 2","***** IPB002205 (DNA gyrase/topoisomerase IV, subunit A) with a combined E-value of 1e-90. IPB002205A 35-53 IPB002205B 68-103 IPB002205C 116-130 IPB002205D 172-193 IPB002205E 215-224 IPB002205F 234-243","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 09:56:15 2006","Wed Feb 6 09:20:11 2002","Tue Feb 1 11:51:29 2005","Wed Feb 6 09:19:24 2002","Wed Feb 6 09:19:24 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1017 is paralogously related (blast p-value < 1e-3) to SMu1100, a DNA topoisomerase IV subunit C.","Wed Feb 6 09:28:27 2002","Tue Feb 1 11:51:29 2005","pdb1AB4 59kda Fragment Of Gyrase A From E. Coli 478 1e-135pdb1BJT Topoisomerase Ii Residues 409 - 1201 >gi1633273p... 72 3e-013","SMU.1114c","","Residues 35 to 482 (E-value = 1.4e-304) place SMu1017 in the DNA_topoisoIV family which is described as DNA gyrase/topoisomerase IV, subunit A (PF00521)Residues 506 to 555 (E-value = 6.5e-13) place SMu1017 in the DNA_gyraseA_C family which is described as DNA gyrase C-terminal domain, beta-propeller (PF03989)Residues 556 to 608 (E-value = 2.6e-16) place SMu1017 in the DNA_gyraseA_C family which is described as DNA gyrase C-terminal domain, beta-propeller (PF03989)Residues 613 to 660 (E-value = 3.7e-12) place SMu1017 in the DNA_gyraseA_C family which is described as DNA gyrase C-terminal domain, beta-propeller (PF03989)Residues 661 to 710 (E-value = 7e-13) place SMu1017 in the DNA_gyraseA_C family which is described as DNA gyrase C-terminal domain, beta-propeller (PF03989)Residues 711 to 761 (E-value = 1.7e-12) place SMu1017 in the DNA_gyraseA_C family which is described as DNA gyrase C-terminal domain, beta-propeller (PF03989)Residues 762 to 811 (E-value = 2.1e-15) place SMu1017 in the DNA_gyraseA_C family which is described as DNA gyrase C-terminal domain, beta-propeller (PF03989)","Tue Feb 1 11:51:29 2005","","","Lee SF, McGavin MK.Identification of a point mutation resulting in loss of cell wall anchoring activity of SrtA of Streptococcus mutans NG5.Infect Immun. 2004 Jul;72(7):4314-7.PMID: 15213182","Yan,S.S., Fox,M.L., Holland,S.M., Stock,F., Gill,V.J. andFedorko,D.P.Resistance to multiple fluoroquinolones in a clinical isolate ofStreptococcus pyogenes: identification of gyrA and parC andspecification of point mutations associated with resistanceAntimicrob. Agents Chemother. 44 (11), 3196-3198 (2000)PubMed: 11036052Gonzalez,I., Georgiou,M., Alcaide,F., Balas,D., Linares,J. and dela Campa,A.G.Fluoroquinolone resistance mutations in the parC, parE, and gyrAgenes of clinical isolates of viridans group streptococciAntimicrob. Agents Chemother. 42 (11), 2792-2798 (1998)PubMed: 9797205Ferrandiz,M.J., Fenoll,A., Linares,J. and De La Campa,A.G.Horizontal transfer of parC and gyrA in fluoroquinolone-resistantclinical isolates of Streptococcus pneumoniaeAntimicrob. Agents Chemother. 44 (4), 840-847 (2000)PubMed: 10722479Pan,X.S. and Fisher,L.M.Streptococcus pneumoniae DNA gyrase and topoisomerase IV:overexpression, purification, and differential inhibition byfluoroquinolonesAntimicrob. Agents Chemother. 43 (5), 1129-1136 (1999)PubMed: 10223925","Thu Aug 3 09:56:15 2006","Wed Feb 6 09:24:03 2002","1","","","SMU.1114c","113" "SMu1018","1056409","1057395","987","ATGACTGCAACTAAACAACATAAAAAAGTCATCCTTGTTGGTGATGGTGCTGTAGGTTCATCTTACGCTTTCGCTCTCGTTAACCAAGGAATTGCTCAAGAACTTGGTATTATTGAAATTCCTCAATTATTTGAAAAAGCCGTTGGCGACGCTCTTGATCTTAGTCATGCACTTGCTTTTACTTCACCAAAAAAAATCTATGCAGCTAAATATGAAGACTGTGCGGATGCTGACCTTGTTGTTATCACTGCTGGTGCACCCCAAAAACCAGGCGAAACTCGCCTCGATCTCGTTGGTAAAAATCTTGCCATCAATAAATCAATTGTTACTCAAGTTATAGAATCAGGCTTTAATGGTATCTTCCTCGTTGCTGCTAACCCAGTTGATATCTTAACTTATGCTACATGGAAATTCTCAGGTTTCCCTGCCGAAAAAGTTATTGGCTCAGGTACTTCACTTGATACTGCTCGTTTCCGTCAAGCACTTGCTGAAAAACTTGATGTTGATGCGCGTTCAGTCCATGCTTACATTATGGGTGAACATGGTGACTCAGAATTTGCAGTATGGTCTCATGCCAATGTAGCTGGTGTTAACCTTGAAAACTATCTTCAAGATGTTCAAAATTTCAATGGCGAAGAATTGATTGACTTATTTGAAGGTGTTCGCGATGCTGCCTATACAATCATCAATAAAAAAGGTGCAACTTTCTATGGTATTGCTGTTGCCCTTGCTCGTATCACTAAGGCTATTCTTGATGACGAAAATGCCATATTGCCACTTTCAGTATTTCAAGATGGCCAATATGGTTTCAATGAAGTCTTTATCGGTCAGCCCGCTATCGTAGGTGCACATGGTATTGTTCGCCCAGTAAATATTCCTTTGAACGATGCTGAAAAACAAAAGATGCAAGCTTCTGCAAAAGAATTAAAAGCTATCATTGACGAAGCCTTCTCTAAAGAAGAATTTGCTGCTGCAGCTCGTAACTAA","4.90","-10.58","35231","MTATKQHKKVILVGDGAVGSSYAFALVNQGIAQELGIIEIPQLFEKAVGDALDLSHALAFTSPKKIYAAKYEDCADADLVVITAGAPQKPGETRLDLVGKNLAINKSIVTQVIESGFNGIFLVAANPVDILTYATWKFSGFPAEKVIGSGTSLDTARFRQALAEKLDVDARSVHAYIMGEHGDSEFAVWSHANVAGVNLENYLQDVQNFNGEELIDLFEGVRDAAYTIINKKGATFYGIAVALARITKAILDDENAILPLSVFQDGQYGFNEVFIGQPAIVGAHGIVRPVNIPLNDAEKQKMQASAKELKAIIDEAFSKEEFAAAARN","1057403","For other 'lct' genes see SMu1050 (lctF); SMu1051 (lctE) and SMu1052 (lctG) .","L-lactate dehydrogenase","Cytoplasm","Several matches in gapped BLAST to L-lactate dehydrogenase: residues 1-328 are 96% similar to the previously published enzyme in S.mutans (gi|126068|). Residues 1-314 are 90% similar to the enzyme from S.pneumoniae (gi|4138534|).Residues 1-328 are 78% similar to the enzyme from S.pyogenes (gi|15675128|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0959 (1e-154).","

InterPro
IPR001236
Family

Lactate/malate dehydrogenase
G3DSA:3.90.110.10	$\"[149-323]T$	lact_mal_DH
PF00056	$\"[8-149]T$	Ldh_1_N
PF02866	$\"[151-320]T$	Ldh_1_C

InterPro
IPR001557
Family

L-lactate/malate dehydrogenase
PR00086	$\"[9-33]T$ $\"[36-60]T$ $\"[122-142]T$ $\"[146-164]T$ $\"[176-189]T$	LLDHDRGNASE
PIRSF000102	$\"[9-320]T$	Lac_mal_DH

InterPro
IPR011304
Family

L-lactate dehydrogenase
TIGR01771	$\"[12-311]T$	L-LDH-NAD
PS00064	$\"[178-184]T$	L_LDH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[8-148]T$	G3DSA:3.40.50.720
PTHR11540	$\"[6-315]T$	PTHR11540
PTHR11540:SF3	$\"[6-315]T$	PTHR11540:SF3
SSF51735	$\"[3-150]T$	SSF51735
SSF56327	$\"[150-316]T$	SSF56327

","BeTs to 13 clades of COG0039COG name: Malate/lactate dehydrogenasesFunctional Class: CThe phylogenetic pattern of COG0039 is amt-YQvceBrh--gpo-inxNumber of proteins in this genome belonging to this COG is 1","***** IPB001557 (L-lactate dehydrogenase) with a combined E-value of 5.8e-145. IPB001557A 9-40 IPB001557B 70-119 IPB001557C 122-164 IPB001557D 172-197 IPB001557E 217-258 IPB001557F 272-310***** IPB001252 (Malate dehydrogenase active site) with a combined E-value of 1.1e-08. IPB001252 76-106","Residues 129-313 are identical to a (DEHYDROGENASE OXIDOREDUCTASE NAD L-LACTATE GLYCOLYSIS) protein domain (PD000436) which is seen in LDH_STRMU.Residues 9-128 are 36% similar to a (DEHYDROGENASE OXIDOREDUCTASE UDP-GLUCOSE NAD COMPLETE) protein domain (PD001278) which is seen in MDH_BACTC.Residues 129-190 are 37% similar to a (M CHAIN FIS EAKLY) protein domain (PD391427) which is seen in Q9NUX7_HUMAN.Residues 9-128 are 99% similar to a (DEHYDROGENASE OXIDOREDUCTASE NAD L-LACTATE GLYCOLYSIS) protein domain (PD000350) which is seen in LDH_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 25 12:54:14 2002","Wed Feb 6 09:50:07 2002","Tue Oct 15 12:34:37 2002","Wed Feb 6 09:49:05 2002","Wed Feb 6 09:49:05 2002","Wed Feb 6 09:49:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1018 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 6 09:49:05 2002","Wed Feb 6 09:49:05 2002","pdb|1LLC| L-Lactate Dehydrogenase (E.C.1.1.1.27) Complex Wit... 422 2e-119pdb|1LDN|A Chain A, L-Lactate Dehydrogenase (E.C.1.1.1.27) Comp... 328 6e-091pdb|2LDB| L-Lactate Dehydrogenase (E.C.1.1.1.27) Complex With... 328 6e-091","SMU.1115","","Residues 8 to 149 (E-value = 1.8e-78) place SMu1018 in the Ldh_1_N family which is described as lactate/malate dehydrogenase, NAD binding domain (PF00056)Residues 151 to 320 (E-value = 2e-90) place SMu1018 in the Ldh_1_C family which is described as lactate/malate dehydrogenase, alpha/beta C-terminal domain (PF02866)","Wed Feb 6 09:49:05 2002","24379547","","Hillman JD. Genetically modified Streptococcus mutans for the prevention of dental caries.Antonie Van Leeuwenhoek. 2002 Aug;82(1-4):361-6.PMID: 12369203Duncan,M.J. and Hillman,J.D.DNA sequence and in vitro mutagenesis of the gene encoding thefructose-1,6-diphosphate-dependent L-(+)-lactate dehydrogenase ofStreptococcus mutansInfect. Immun. 59 (11), 3930-3934 (1991)PubMed: 1937751","Jado,I., Fenoll,A., Casal,J. and Perez,A.Nucleotide sequence and chromosomal location of L-lactatedehydrogenase gene from Streptococcus pneumoniaeCurr. Microbiol. 37 (2), 77-79 (1998)PubMed: 9662606Ito,Y. and Sasaki,T.Cloning and nucleotide sequencing of L-lactate dehydrogenase genefrom Streptococcus thermophilus M-192Biosci. Biotechnol. Biochem. 58 (9), 1569-1573 (1994)PubMed: 7765475","Fri Oct 25 12:54:14 2002","Wed Feb 6 09:54:03 2002","1","","","SMU.1115","347" "SMu1019","1058593","1057457","1137","ATGGCGAATCAAGATTTCACTAGGAAAAATAAAAAACCGACGACACATGATAAACAAAAGAGATTGGCTGAAGAAGAATTAGAAAAAAGAATTTCTCGTCTTCAGTTAGCTATAAAAAAAGAAAAAGATCCTAAGTTGAAACAAGAAATTTCCCTTTTGCTACAACAGTACGAAACAGAGCATAAAAATTTATTGCAGAAAAATCGTTTTCGCACTTATTTAATAGCATCAGTATGTATTATAGGAGTAATCATAGCTATTCTCTTTCTTATGTTTTTAAAAGACAGCTCTCGACCTATCTCTAATACCTCAACTTCTAAGAGAACCACAGCAACGTCATCTCTCCAAAAGAAAGATAAAACTAACAAGACAAAATCTGATCGTAGTCAAAGCCAGAAAACTAGAGCTGTTTTTCCAGTAAAGTTAAGAGGAACGTGGTATGGTTATGTTGATAATCTCCAAAAAGATATTCAAATGACCTTTTCTAAAAATGGTGTGATAAAAACAGTTATTGGTTCAGAAAATTACACAAGTAGAATTAAAAATATAGAGAGAGTGGGCGTTAATACTTACTGTTATCATTTTGTTAAAGGGACACAGCCAAGTGGTTTGGTGGCAGGAGCACAACTAGGAGGAGTTTACGTTAGATATGCTTATGGTGTCTATATTGGAGATGGCTATATTAAACCTTTAGTTTGGCAAACAGGTGTTGACAGCGATTTTGATTATTCTCAACCTTTAACTAATATTGGGTTGGATTACCAGTTGCAAAAAGGAAGACCTTCATCACAGAAGTCTTCTCATAGAAAGAGTAGTGACAGTCAAGTAGATACAAAAAATCTTACTACTCAACAGGTTGAAGATTGGGTTATCGCAAATTATCTGGAGAATCGTAAAGATAGTCGTTTTACTAAAAAAGATTTCACTATTGAAAGTTGGAAATCTGATACGGATGGTTTGGTTTATGCTACTATTAAGGAAAATCATCAGTCTGATGCAATGAAGCAAGCAGGAGCAGATTCTAATACTAGTCCAACTGTTGCTCATTATCGTATTAATGCTAATGGAGAGTTGGAAAAGTCGTCGGATGGTCTTAACGGTTGGACTGTTGTTAGCAGGACTTACTACAGTGATTAA","10.40","20.36","43016","MANQDFTRKNKKPTTHDKQKRLAEEELEKRISRLQLAIKKEKDPKLKQEISLLLQQYETEHKNLLQKNRFRTYLIASVCIIGVIIAILFLMFLKDSSRPISNTSTSKRTTATSSLQKKDKTNKTKSDRSQSQKTRAVFPVKLRGTWYGYVDNLQKDIQMTFSKNGVIKTVIGSENYTSRIKNIERVGVNTYCYHFVKGTQPSGLVAGAQLGGVYVRYAYGVYIGDGYIKPLVWQTGVDSDFDYSQPLTNIGLDYQLQKGRPSSQKSSHRKSSDSQVDTKNLTTQQVEDWVIANYLENRKDSRFTKKDFTIESWKSDTDGLVYATIKENHQSDAMKQAGADSNTSPTVAHYRINANGELEKSSDGLNGWTVVSRTYYSD","1057471","","hypothetical protein","Extracellular, Membrane","Only one weak hit in gapped BLAST to a hypothetical protein: residues 115-255 are 26% similar to the protein from S.pyogenes (gi|15675830|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2068 (4e-10).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[73-93]?$	transmembrane_regions

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[3-25]T$ $\"[164-189]T$ $\"[249-263]T$ $\"[289-296]T$ $\"[412-427]T$	PNDRDTASEI

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[111-205]T$	FAD_pyr_redox
PF00070	$\"[164-256]T$	Pyr_redox

InterPro
IPR004099
Domain

Pyridine nucleotide-disulphide oxidoreductase dimerisation region
G3DSA:3.30.390.30	$\"[347-456]T$	Pyr_redox_dim
PF02852	$\"[340-447]T$	Pyr_redox_dim

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[3-25]T$ $\"[164-189]T$ $\"[249-263]T$ $\"[289-296]T$	FADPNR
PF07992	$\"[3-300]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[3-125]T$ $\"[163-339]T$	G3DSA:3.50.50.60
PTHR22912	$\"[5-453]T$	PTHR22912
PTHR22912:SF2	$\"[5-453]T$	PTHR22912:SF2
SSF51905	$\"[164-332]T$	SSF51905
SSF51971	$\"[1-235]T$	SSF51971
SSF55424	$\"[335-456]T$	SSF55424

","BeTs to 10 clades of COG0446COG name: Uncharacterized NAD(FAD)-dependent dehydrogenasesFunctional Class: RThe phylogenetic pattern of COG0446 is AmtKyQVCE-R---gpol---Number of proteins in this genome belonging to this COG is 1","***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 1.1e-27. PR00368A 3-25 PR00368B 107-116 PR00368C 164-189 PR00368D 249-263 PR00368E 289-296","Residues 164-432 are identical to a (OXIDOREDUCTASE FLAVOPROTEIN FAD CENTER REDOX-ACTIVE) protein domain (PD000139) which is seen in Q54453_STRMU.Residues 407-456 are 52% similar to a (NADH OXIDOREDUCTASE CENTER OXIDASE) protein domain (PD406103) which is seen in NAPE_ENTFA.Residues 30-86 are 54% similar to a (FLAVOPROTEIN OXIDOREDUCTASE FAD NADH) protein domain (PD237229) which is seen in Q59917_TREHY.Residues 203-294 are 34% similar to a (PROTEOME FAD NADH COMPLETE) protein domain (PD316559) which is seen in Q9RVN5_DEIRA.Residues 85-163 are identical to a (FAD NADH FLAVOPROTEIN OXIDOREDUCTASE) protein domain (PD348095) which is seen in Q54453_STRMU.Residues 331-457 are 25% similar to a (COENZYME A DISULFIDE FAD) protein domain (PD396653) which is seen in O52582_STAAU.Residues 3-84 are identical to a (NADH OXIDASE OXIDOREDUCTASE FLAVOPROTEIN) protein domain (PD328777) which is seen in Q54453_STRMU.Residues 296-405 are 69% similar to a (NADH OXIDASE FAD FLAVOPROTEIN) protein domain (PD414899) which is seen in O84925_STRPN.Residues 296-405 are 56% similar to a (NADH OXIDASE COMPLETE FLAVOPROTEIN) protein domain (PD159897) which is seen in Q9CIG9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 09:43:16 2006","Wed Feb 6 10:36:55 2002","Thu Aug 3 09:43:16 2006","Wed Feb 6 10:36:55 2002","Wed Feb 6 10:36:55 2002","Wed Feb 6 10:36:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1020 is paralogously related (blast p-value < 1e-3) to SMu1299 and SMu0116, both predicted dihydrolipoamide dehydrogenase; SMu0126 and SMu0762, both predicted glutathione reductases; SMu0693, a predicted NADH oxidase/alkyl hydroperoxidase reductase; and SMu0420, a predicted NADH oxidase.","Wed Feb 6 10:45:07 2002","Thu Aug 3 09:43:16 2006","pdb1F8WA Chain A, Crystal Structure Of Nadh Peroxidase Mutant... 295 6e-081pdb1NPX Nadh Peroxidase (E.C.1.11.1.1) Non-Active Form With... 294 2e-080pdb1NHS Nadh Peroxidase (Npx) (E.C.1.11.1.1) Mutant With S... 293 4e-080","SMU.1117c","","Residues 3 to 305 (E-value = 2.3e-79) place SMu1020 in the Pyr_redox family which is described as Pyridine nucleotide-disulphide oxidoreductase (PF00070)Residues 340 to 447 (E-value = 8.9e-07) place SMu1020 in the Pyr_redox_dim family which is described as Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (PF02852)","Thu Aug 3 09:43:16 2006","","","Abranches J, Lemos JA, Burne RA.,Osmotic stress responses of Streptococcus mutans UA159.FEMS Microbiol Lett. 2006 Feb;255(2):240-6.PMID: 16448501Matsumoto,J., Higuchi,M., Shimada,M., Yamamoto,Y. and Kamio,Y.Molecular cloning and sequence analysis of the gene encoding theH2O-forming NADH oxidase from Streptococcus mutansBiosci. Biotechnol. Biochem. 60 (1), 39-43 (1996)PubMed: 8824824","Auzat,I., Chapuy-Regaud,S., Le Bras,G., Dos Santos,D.,Ogunniyi,A.D., Le Thomas,I., Garel,J.R., Paton,J.C. and Trombe,M.C.The NADH oxidase of Streptococcus pneumoniae : its involvement incompetence and virulenceMol. Microbiol. 34 (5), 1018-1028 (1999)PubMed: 10594826Higuchi M, Yamamoto Y, Kamio Y.Molecular biology of oxygen tolerance in lactic acid bacteria: Functions of NADH oxidases and Dpr in oxidative stress.J Biosci Bioeng. 2000;90(5):484-93.PMID: 16232897","Wed Feb 6 10:39:13 2002","Thu Aug 3 09:43:16 2006","1","","","SMU.1117c","112" "SMu1021","1061329","1060373","957","ATGAGTTTAGAAAATATGTTAGCTCTTTTGATATCGTCAATGCTAGTTTATGCGACCCCTCTTATTTTTACAAGTATAGGTGGCGTCTTTTCTGAAAGATCAGGTGTTGTTAATGTAGGTCTTGAAGGTATTATGGTTATGGGAGCTTTTGCTGGTGTTGTTTTTAATATCGAATTTGCTCACTCTTTTGGCAAGGCTACTCCTTGGATTGCTGCTCTTGTAGGCGGTCTGGTTGGCTTACTTTTTTCTTTACTTCATGCTCTAGCAACAATTAATTTTCGAGCAGATCATATTGTTTCTGGTACTGTGCTTAATCTTTTAGCTCCTTCTTTAGCTGTTTTCTTTGTTAAAGCACTGTATAACAAGGGACAGACAGATAATATCAGTCAATCTTTTGGTAAATTTGATTTTCCAATTTTGTCACATATTCCTTTTTTGGGTCCTATCTTCTTTCAAGGGACTAGTTTAGTAGCCTATCTAGCTGTTCTCTTTTCAGTCTTTGCTTGGTTCATACTTACCAAAACGAAATTTGGTTTGCGATTGCGTTCAGTTGGTGAACACCCACAAGCTGCGGATACTTTAGGAATCAATGTTTATTTGATGCGTTATCTCGGTGTTATGATTTCAGGTCTTCTGGGTGGAATAGGCGGAGCGATTTATGCACAGTCCATCTCTGTGAACTTTGCAGGAACGACCATTTTGGGACCAGGTTTCATTGCTTTGGCAGCTATGATTTTTGGAAAATGGAATCCGATAGGAGCTATGTTATCAAGCCTTTTCTTTGGTCTTTCACAGAGTTTAGCAGTTATTGGCGGTCAATTACCTTTTTTATCAAAAATTCCTACAGTTTATCTGCAAATTGCACCTTATGCTTTAACGATTCTTGTATTAGCAGTCTTCTTTGGACAAGCAGTTGCTCCAAAAGCGGATGGTATTAATTATATTAAATCAAAATAA","10.40","7.18","33762","MSLENMLALLISSMLVYATPLIFTSIGGVFSERSGVVNVGLEGIMVMGAFAGVVFNIEFAHSFGKATPWIAALVGGLVGLLFSLLHALATINFRADHIVSGTVLNLLAPSLAVFFVKALYNKGQTDNISQSFGKFDFPILSHIPFLGPIFFQGTSLVAYLAVLFSVFAWFILTKTKFGLRLRSVGEHPQAADTLGINVYLMRYLGVMISGLLGGIGGAIYAQSISVNFAGTTILGPGFIALAAMIFGKWNPIGAMLSSLFFGLSQSLAVIGGQLPFLSKIPTVYLQIAPYALTILVLAVFFGQAVAPKADGINYIKSK","1060387","For other components see SMu1023 (NBD1 and NBD2); SMu1022 (MSD1) and SMu1024 (SBP1). ","ribonucleoside ABC transporter permease","Membrane, Extracellular","Several matches in gapped BLAST to sugar ABC transporter (permease protein): residues 1-318 are 71% similar to the enzyme in S.pyogenes (gi|15675189|) and are 68% similar to the protein from S.pneumoniae (gi|15900735|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0957 (1e-126).","

InterPro
IPR001851
Family

Bacterial inner-membrane translocator
PF02653	$\"[10-297]T$	BPD_transp_2

","BeTs to 7 clades of COG1079COG name: Uncharacterized ABC-type transport systems, permease componentsFunctional Class: RThe phylogenetic pattern of COG1079 is A--K--V--B----GPOL---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 270-318 are 63% similar to a (PROTEOME COMPLETE SUGAR ABC) protein domain (PD411193) which is seen in Q9CFY1_LACLA.Residues 2-255 are 55% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000838) which is seen in Q9CFY1_LACLA.Residues 7-57 are 50% similar to a (PROTEOME SYSTEM COMPLETE LONG) protein domain (PD329058) which is seen in Q9Y8P7_AERPE.Residues 227-318 are 37% similar to a (PROTEOME COMPLETE SUGAR ABC) protein domain (PD393791) which is seen in Q9WXW0_THEMA.Residues 91-245 are 28% similar to a (MG121 TRANSMEMBRANE) protein domain (PD399227) which is seen in Y121_MYCGE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 13:58:13 2002","Wed Feb 6 10:50:35 2002","Tue Oct 15 12:44:08 2002","Wed Feb 6 10:48:25 2002","","Wed Feb 6 10:48:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1021 is paralogously related (blast p-value < 1e-3) to SMu1022, SMu1519, SMu1520, SMu1006, and SMu1317, all predicted ABC transporter, permease protein.","Wed Feb 6 10:52:52 2002","","No significant hits to the NCBI PDB database.","SMU.1118c","","Residues 10 to 297 (E-value = 6.9e-42) place SMu1021 in the BPD_transp_2 family which is described as Branched-chain amino acid transport system / permease component (PF02653)","Wed Feb 6 10:48:25 2002","24379550",""," Webb AJ, Hosie AH.A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans.J Bacteriol. 2006 Dec;188(23):8005-12. Epub 2006 Sep 22.PMID: 16997965","","","","1","","","SMU.1118c","346" "SMu1022","1062407","1061331","1077","ATGTCTAAGAAAACACAAAAATTGGTAGTTCCTCTGATTTCAGTTATCTTGGGGATTATACTAGGTGCCATTATCATGATGATTTTTGGCTATGATCCTATTTGGGCCTATGAAGGGTTATTTCAAAAAGCATTTGGCAGTCTCAAGGATATTGGCGAAATTTTTCGCGCTATGAGCCCTTTGATTTTAATTGCTCTTGGTTTTGCTGTTGCAAGCCGTGCGGGCTTTTTCAATATTGGTTTATCTGGTCAAGCCTATGCTGGTTGGATTGCTGCTGGTTGGTTTGCTCTAGCTAATCCTAGCCTGCCTCGTCCCCTGATGATTCTAATGACAGTGCTTATTGGAGCAGCATCAGGAGGTGTTGTCGGTGCTATTCCTGGCTTCTTGCGAGCTTATTTAGGAACCAGTGAAGTCATTGTAACGATTATGATGAATTACATTGTTCTTTATATTGGCAATGCTATTATTCAAGACGGCTTTGCTAAGAATATTATGAGAAATTCAGACTCTAGTATCTATGTTGGTCATAATGCCAGCTATCAGACAGAATGGCTGCGTGCTTTGACAAATAATTCACGAATGAATATCGGCTTTTTCTTGGCAATCATTGCTATTGTAGTTGTCTGGTATTTACTCAATAAGACAACTCTGGGATTTGAAATCCGTTCAGTGGGGCTCAATCCGCATGCTAGTGAATATGCTGGTATGTCAGCTAAAAGAACCATCGTTCTTTCAATGATTATTTCAGGTGCTCTTGCTGGATTAGGTGGAGTTGTTGAAGGATTGGGAACCTTTGGCAATGTTTATGTGCAAACAAGTTCCTTGGCTATTGGTTTTGACGGAATGGCGGTCAGTCTTTTGGCGTCTAATTCTCCAATTGGTATCTTCCTTTCAGCCTTTTTATTTGGAGCACTCAGTGTTGGTGCACCGGGTATGAGTATTAGTGATGCTACTCATGTTGGCACACCGCCTGAATTGATAAAAGTAGTGACTGCTTTGATTATTTTCTTCGTTGGAGCTCACTATATTATTGAACATTACATTAAACCTAGAAAAAAAGTGGAAGGTGGTCAGTAA","10.30","7.19","38043","MSKKTQKLVVPLISVILGIILGAIIMMIFGYDPIWAYEGLFQKAFGSLKDIGEIFRAMSPLILIALGFAVASRAGFFNIGLSGQAYAGWIAAGWFALANPSLPRPLMILMTVLIGAASGGVVGAIPGFLRAYLGTSEVIVTIMMNYIVLYIGNAIIQDGFAKNIMRNSDSSIYVGHNASYQTEWLRALTNNSRMNIGFFLAIIAIVVVWYLLNKTTLGFEIRSVGLNPHASEYAGMSAKRTIVLSMIISGALAGLGGVVEGLGTFGNVYVQTSSLAIGFDGMAVSLLASNSPIGIFLSAFLFGALSVGAPGMSISDATHVGTPPELIKVVTALIIFFVGAHYIIEHYIKPRKKVEGGQ","1061345","For other components see SMu1023 (NBD1) and (NBD2), SMu1021 (MSD2) and SMu1024 (SBP1).Note tandem repeats at 1062131,1062161.","ribonucleoside ABC transporter permease","Membrane, Cytoplasm","Several matches in gapped BLAST to sugar ABC transporter (permease protein): residues 1-358 are 64% similar to the enzyme in S.pyogenes (gi|15675190|) and are 61% similar to the protein from S.pneumoniae (gi|15900734|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0956 (1e-133).","

InterPro
IPR001851
Family

Bacterial inner-membrane translocator
PF02653	$\"[50-339]T$	BPD_transp_2

","BeTs to 7 clades of COG1079COG name: Uncharacterized ABC-type transport systems, permease componentsFunctional Class: RThe phylogenetic pattern of COG1079 is A--K--V--B----GPOL---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 200-297 are 32% similar to a (PROTEOME RIBOSE/GALACTOSE DOMAIN COMPLETE) protein domain (PD415440) which is seen in Y120_MYCPN.Residues 62-303 are 36% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000838) which is seen in O05254_BACSU.Residues 61-156 are 52% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD118173) which is seen in Q9CFY2_LACLA.Residues 269-340 are 34% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD038573) which is seen in Q9WXV9_THEMA.Residues 185-249 are 32% similar to a (PROTEOME COMPLETE OF ABC) protein domain (PD292195) which is seen in Q9I6Z5_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 30 11:25:43 2002","Mon Oct 28 09:59:52 2002","Tue Oct 15 12:49:04 2002","Wed Feb 6 10:56:19 2002","","Wed Feb 6 10:56:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1022 is paralogously related (blast p-value < 1e-3) to SMu1021, and SMu1520, both predicted ABC transporter, permease protein. ","Wed Feb 6 10:56:19 2002","","No significant hits to the NCBI PDB database.","SMU.1119c","","Residues 50 to 339 (E-value = 5.3e-48) place SMu1022 in the BPD_transp_2 family which is described as Branched-chain amino acid transport system / permease component (PF02653)","Wed Feb 6 10:56:19 2002","24379551",""," Webb AJ, Hosie AH.A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans.J Bacteriol. 2006 Dec;188(23):8005-12. Epub 2006 Sep 22.PMID: 16997965","","","","1","","","SMU.1119c","345" "SMu1023","1063932","1062400","1533","ATGGCGCAACATGTCATTGAAATGAGAGAGATTACTAAAAAATTTGATGATTTTGTGGCTAATGATCACATCAATCTTGATCTCAGAAAAGGTGAGATTCATGCTTTGCTTGGTGAAAATGGAGCAGGGAAGTCAACTTTGATGAATATGCTTGCAGGTTTGCTTGAACCTACTAGTGGTAGCATTAAGATTAATGGTTCGGCTGTTACGATTGATTCGCCCTCTAAGTCAGCTCAATTAGGTATCGGGATGGTTCACCAACATTTTATGTTAGTTGAAGCATTTACGGTTACTGAAAATATCATTTTGGGAAATGAAGTTGTCAAAAATGGTATATTAGATCTTAAAAAAGCTGGCCAAGAAATTAAAGCACTTTCTGAAAAGTATGGTTTAGCTGTAGATCCCAATGCTAAGATTGCTGATATTTCTGTCGGTGCTCAGCAACGTGTTGAAATTCTTAAAACACTTTATCGTGGTGCTGATATTTTAATTTTTGATGAACCAACAGCTGTTTTGACACCTTCTGAAATTCAGGAATTGATGACTATCATGAAGAGTCTTGTCAAAGAAGGCAAATCTATTATTTTGATTACTCATAAGTTGGATGAAATTAGGTCAGTAGCTGATCGTGTTACTGTAATTCGTCGCGGTAAGAGTATTGAGACAGTTGAGGTCTCTGGCACCACTTCACAGGATTTAGCTGAGATGATGGTTGGGCGTTCTGTTTCATTTACAATAGAAAAAACGCCAACAAAACCTAAAGAAACCATTTTGTCTATCAAAGATCTTGTAGTCAATGAAAATAGAGGAATTCCTGCTATTAAAGGTTTGTCTTTAGAGGTTAAGGCTGGTGAAATTATCGGTATTGCTGGTATTGATGGCAATGGGCAAAGTGAATTAGTTCAAGCTATCACAGGATTACGTAAGATAAAATCTGGTCATTTAACAATCAAAGGACAAGATGTGACCAAACTTTCGACCCGTAAGATTACAGAGCTCAGTGTTGGTCATGTTCCTGAAGACCGTCATCGTGATGGTCTGATTCTTGAGTTAACTATGGCAGAAAACCTCGCTCTTCAAACATATTATAAGGCCCCCCTAAGTCACAATGGTGTTTTGAATTATAGTAAAATCAATGAACATGGTCGTCACTTAATGCAGGAATTTGATGTTCGCGGAGCTAATGAACTTATTCCAGCCAAAGGATTTTCAGGCGGCAATCAGCAAAAAGCTATCATTGCTCGTGAGGTTGACCGTGATCCAGACTTATTAATTGTTAGTCAGCCGACACGAGGTCTTGATGTTGGAGCTATTGAATATATTCATAAACGTTTAATTGCAGAGCGTGATGAAGGCAAGGCTGTTCTATTAGTCAGTTTTGAACTTGATGAAATTCTCAACCTGTCAGATCGTATTGCTGTTATTCATGATGGTCAAATCCAAGGTATTGTTACACCAGAAACAACTAATAAACAAGAACTAGGAATTTTAATGGCTGGTGGCAGTATTGAAAGGGAGGAAATAAATGTCTAA","6.10","-7.57","55599","MAQHVIEMREITKKFDDFVANDHINLDLRKGEIHALLGENGAGKSTLMNMLAGLLEPTSGSIKINGSAVTIDSPSKSAQLGIGMVHQHFMLVEAFTVTENIILGNEVVKNGILDLKKAGQEIKALSEKYGLAVDPNAKIADISVGAQQRVEILKTLYRGADILIFDEPTAVLTPSEIQELMTIMKSLVKEGKSIILITHKLDEIRSVADRVTVIRRGKSIETVEVSGTTSQDLAEMMVGRSVSFTIEKTPTKPKETILSIKDLVVNENRGIPAIKGLSLEVKAGEIIGIAGIDGNGQSELVQAITGLRKIKSGHLTIKGQDVTKLSTRKITELSVGHVPEDRHRDGLILELTMAENLALQTYYKAPLSHNGVLNYSKINEHGRHLMQEFDVRGANELIPAKGFSGGNQQKAIIAREVDRDPDLLIVSQPTRGLDVGAIEYIHKRLIAERDEGKAVLLVSFELDEILNLSDRIAVIHDGQIQGIVTPETTNKQELGILMAGGSIEREEINV","1062414","For other components see SMu1022 (MSD1);SMu1021 (MSD2) and SMu1024 (SBP1).","ribonucleoside ABC transporter, ATP-binding protein","Membrane, Cytoplasm","Matches in gapped BLAST to ABC transporter PsaA: residues 4-218 are 32% similar and residues 258-481 are 26% similar to the previously published protein in S.mutans (gi|15625442|).Residues 1-510 are 80% similar to the protein from S.pyogenes (gi|15675191|).Residues 3-510 are 75% similar to the protein from S.pneumoniae (gi|15900733|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0955 (0.0).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[143-184]T$ $\"[403-445]T$	ABC_transporter
PF00005	$\"[31-217]T$ $\"[284-478]T$	ABC_tran
PS00211	$\"[403-417]?$	ABC_TRANSPORTER_1
PS50893	$\"[6-241]T$ $\"[258-502]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-218]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-232]T$ $\"[251-506]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-306]T$	PTHR19222
PTHR19222:SF12	$\"[6-306]T$	PTHR19222:SF12
SSF52540	$\"[2-232]T$ $\"[252-493]T$	SSF52540

","BeTs to 8 clades of COG1129COG name: ABC-type sugar (aldose) transport system, ATPase componentFunctional Class: GThe phylogenetic pattern of COG1129 is a--k--V-EB-H--gpOL---Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.3e-25. IPB001140A 20-66 IPB001140B 139-177 IPB001140C 194-223","Residues 334-392 are 72% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE SUGAR) protein domain (PD003603) which is seen in Q9CFY3_LACLA.Residues 80-133 are 64% similar to a (PROTEOME COMPLETE ATP-BINDING TRANSPORT) protein domain (PD404313) which is seen in O05253_BACSU.Residues 74-181 are 27% similar to a (ATP-BINDING PROTEOME COMPLETE LONG) protein domain (PD292101) which is seen in Q9YG38_AERPE.Residues 449-483 are 62% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in O59404_PYRHO.Residues 74-139 are 54% similar to a (ATP-BINDING TRANSPORT SUGAR MEMBRANE) protein domain (PD416141) which is seen in Q9WXV8_THEMA.Residues 74-141 are 72% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD350414) which is seen in Q9CFY3_LACLA.Residues 404-446 are 72% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD022456) which is seen in Q9WXV8_THEMA.Residues 74-219 are 24% similar to a (ATP-BINDING PROTEOME RIBOSE/GALACTOSE) protein domain (PD215671) which is seen in O83322_TREPA.Residues 73-138 are 46% similar to a (ATP-BINDING TRANSPORT MGLA COMPLETE) protein domain (PD331438) which is seen in Q9X776_MYCAA.Residues 449-498 are 90% similar to a (ATP-BINDING PROTEOME TRANSPORT COMPLETE) protein domain (PD416084) which is seen in Q9CFY3_LACLA.Residues 185-225 are 82% similar to a (ATP-BINDING TRANSPORT PROTEOME SUGAR COMPLETE) protein domain (PD404861) which is seen in Q9CFY3_LACLA.Residues 446-484 are 61% similar to a (ATP-BINDING PROTEOME MGLA) protein domain (PD383394) which is seen in O51620_BORBU.Residues 449-500 are 50% similar to a (ATP-BINDING PROTEOME COMPLETE SUGAR) protein domain (PD384098) which is seen in Q9RVR5_DEIRA.Residues 336-445 are 33% similar to a (ATP-BINDING PROTEOME 498AA SYSTEM) protein domain (PD396384) which is seen in Q9Y8P5_AERPE.Residues 71-136 are 44% similar to a (ATPASE) protein domain (PD389663) which is seen in O06761_MYCFE.Residues 22-66 are 71% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CFY3_LACLA.Residues 404-445 are 90% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CFY3_LACLA.Residues 76-135 are 43% similar to a (ATP-BINDING TRANSPORT SUGAR PROTEOME) protein domain (PD002402) which is seen in Q9K7C3_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:03:07 2002","Wed Oct 23 14:52:22 2002","Tue Oct 15 12:50:17 2002","Thu Feb 7 09:09:18 2002","Thu Feb 7 09:09:18 2002","Thu Feb 7 09:09:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1023 is paralogously related (blast p-value < 1e-3) to SMu1380, SMu0418, SMu1518, SMu0517, SMu1920, SMu1003, SMu0731, SMu0390, SMu0849, SMu1751, SMu0218, SMu0976, SMu1079, SMu1649, SMu1757, SMu1762, SMu0596, SMu1517, SMu0916, SMu1093, SMu1949, SMu1288, SMu1001, SMu1316, SMu0786, SMu1068, SMu1246, SMu1231, SMu0944, SMu0971, SMu0884, SMu0374, SMu1210, SMu1950, SMu0805, SMu0594, SMu0335, SMu1428, SMu0825, SMu1064, SMu0950, SMu1410, SMu0666, SMu0216, SMu0837, SMu0476, SMu0907, SMu1065, SMu0234, SMu1811, SMu1710, SMu0258, SMu0235, SMu0164, SMu1545, SMu0986, SMu1050, SMu0824, SMu1959, SMu0823, SMu0752, SMu0836, SMu1306, SMu0224, SMu0475, SMu1036, SMu1037, SMu1724, SMu0987, SMu0024, SMu1202, SMu0729, and SMu1686, all with ATP binding capabilities.","Thu Feb 7 09:13:22 2002","Thu Feb 7 09:09:18 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 109 6e-025pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 92 2e-019","SMU.1120c","","Residues 31 to 217 (E-value = 3.8e-50) place SMu1023 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 284 to 478 (E-value = 3.2e-15) place SMu1023 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Feb 7 09:09:18 2002","",""," Webb AJ, Hosie AH.A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans.J Bacteriol. 2006 Dec;188(23):8005-12. Epub 2006 Sep 22.PMID: 16997965","","","","1","","","SMU.1120c","111" "SMu1024","1065099","1064050","1050","ATGAACAAGAAAATTATTGGTTTAGGGTTAACTGCAGTAGCAGTATTGGGACTTGCTGCTTGTGGAAATCGTGCAGCTAGGGAAAAGGGTAAGGCAAAGACAGACTTAAAAGTCGCTATTGTCACTGATACTGGCGGTGTTGATGACAAATCATTTAATCAATCAGCTTGGGAAGGTTTACAGGCTTGGGGCAAAGATAACGGTCTTAGCAAAGGAAATGGTTTTGATTACTTCCAATCAGCTAGTGAATCCGATTATGCTACTAACCTTGATACAGCTTCATCAAGCGGTTATAAATTAATATTTGGTATTGGCTATGCTTTGCATGATGCTATCGAAAAAACAGCAGCAGATAATAAGAATATCCATTACGTTATTATTGATGATGTTATCCAAAAGAAAAACAATGTCGCTAGTGTTACCTTTGCTGATAATGAAGCTGCTTACCTCGCAGGAATCGCTGCAGCAAAAACAACCAAATCAAAGAAGGTCGGCTTTGTAGGTGGTGTGAAATCTGAAGTGATCACTCGTTTTGAAAAAGGTTTTGAAGCTGGTGTGAAATCAGTTGATAGTTCTATTCAAATTCAAGTTGATTACGCTGGTTCGTTTGGAGATGCAGCCAAAGGTAAGACAATCGCTGCTGCACAATATGCCAGTGGTGCAGATGTTATTTATCAAGCTGCTGGTGGTACTGGTGCTGGGGTATTTAGTGAAGCCAAAGCTGTTAATGAAAAGAAAAAAGAAAATAAAAAAGTTTGGGTCATTGGAGTTGACCGAGATCAAGCTGCTGAAGGTAAATATACTTCTAAGGATGGTAAGAAATCTAACTTTGTTCTTGCTTCTTCTTTAAAAGAAGTTGGTAAGGCTGTTCAGTTGATTTCAACAAACACTTCTAAGAAAAAATTTCCGGGCGGTAAAGTGACAACTTATGGTCTTAAAGATAAAGGAGTTGATTTAGTACCAACACATTTATCTAAAGAGGGTAAAAAGGCTGTTGATGATGCTAAGAAGAAAATTGTATCTGGTGATGTTAAAGTTCCAGAAAAATAA","10.20","13.68","36628","MNKKIIGLGLTAVAVLGLAACGNRAAREKGKAKTDLKVAIVTDTGGVDDKSFNQSAWEGLQAWGKDNGLSKGNGFDYFQSASESDYATNLDTASSSGYKLIFGIGYALHDAIEKTAADNKNIHYVIIDDVIQKKNNVASVTFADNEAAYLAGIAAAKTTKSKKVGFVGGVKSEVITRFEKGFEAGVKSVDSSIQIQVDYAGSFGDAAKGKTIAAAQYASGADVIYQAAGGTGAGVFSEAKAVNEKKKENKKVWVIGVDRDQAAEGKYTSKDGKKSNFVLASSLKEVGKAVQLISTNTSKKKFPGGKVTTYGLKDKGVDLVPTHLSKEGKKAVDDAKKKIVSGDVKVPEK","1064064","For other components see SMu1023 (NBD1 and NBD2); SMu1022 (MSD1) and SMu1021 (MSD2).","ribonucleoside ABC transporter, solute-binding protein","Extracellular, Periplasm","Several matches in gapped BLAST to lipoprotein: residues 1-349 are 65% similar to the enzyme in S.pyogenes (gi15675192). Residues 23-349 are 60% similar to the protein from S.pneumoniae (gi15900732).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0954 (1e-130).","

InterPro
IPR000217
Family

Tubulin
PS00227	$\"[228-234]?$	TUBULIN

InterPro
IPR003760
Family

Basic membrane lipoprotein
PF02608	$\"[10-349]T$	Bmp

noIPR
unintegrated

unintegrated
PS51257	$\"[1-21]T$	PROKAR_LIPOPROTEIN
SSF53822	$\"[35-315]T$	SSF53822

","BeTs to 7 clades of COG1744COG name: Predicted lipoprotein, Med/BMP familyFunctional Class: NThe phylogenetic pattern of COG1744 is a--k--v--B----gpOL---Number of proteins in this genome belonging to this COG is 1","***** IPB003760 (Basic membrane lipoprotein) with a combined E-value of 5.1e-29. IPB003760A 45-56 IPB003760B 136-165 IPB003760C 216-229 IPB003760D 253-262","Residues 30-71 are 71% similar to a (LIPOPROTEIN PRECURSOR SIGNAL MACROPHAGE) protein domain (PD022289) which is seen in YUFN_BACSU.Residues 26-238 are 60% similar to a (MEMBRANE LIPOPROTEIN PRECURSOR SIGNAL) protein domain (PD004667) which is seen in Q9CFM9_LACLA.Residues 253-349 are 47% similar to a (LIPOPROTEIN MEMBRANE PRECURSOR SIGNAL) protein domain (PD009858) which is seen in Q9CFM9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:53:08 2002","Mon Sep 11 17:00:44 2006","Mon Sep 11 16:53:02 2006","Thu Feb 7 09:25:58 2002","Thu Feb 7 09:25:58 2002","Thu Feb 7 09:25:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1024 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 7 09:25:58 2002","","No significant hits to the NCBI PDB database.","SMU.1121c","","Residues 10 to 349 (E-value = 3.8e-80) place SMu1024 in the Bmp family which is described as Basic membrane protein (PF02608)","Thu Feb 7 09:25:58 2002","24379553",""," Webb AJ, Hosie AH.A member of the second carbohydrate uptake subfamily of ATP-binding cassette transporters is responsible for ribonucleoside uptake in Streptococcus mutans.J Bacteriol. 2006 Dec;188(23):8005-12. Epub 2006 Sep 22.PMID: 16997965","","Fri Mar 16 12:32:05 2007","","1","","","SMU.1121c","344" "SMu1025","1065575","1065189","387","GTGGTTATTGATTTAATCAGAACAGCTATTAAAGCTAGTAAAAATGCTTATGTTCCTTATTCACATTTTCCGATTGGAGCAGCACTTAAAACCAAGTCCGGTAAAATCTATCAAGGCTGTAACATTGAAAATGCCAGTTTTGGATTGACCAATTGCGGTGAACGAACAGCAATTTTTAAAGCTATTTCTGAAGGTTATCGTGACTTAGAAGAAATTGCTATTTATGGTGAGACGCAAAAGCCTATTTCGCCTTGTGGTGCTTGCCGTCAAGTAATGGCTGAATTTTTTGAACCATCTGCAAAAGTTACTTTAATTGCAAAGGGTGGTAAGACGGTCGTGATGACAGTCGAAGAGTTACTTCCTTATTCCTTTAGAGAGTTAAAGTAA","8.50","3.04","13997","MVIDLIRTAIKASKNAYVPYSHFPIGAALKTKSGKIYQGCNIENASFGLTNCGERTAIFKAISEGYRDLEEIAIYGETQKPISPCGACRQVMAEFFEPSAKVTLIAKGGKTVVMTVEELLPYSFRELK","1065203","","cytidine deaminase","Cytoplasm","Matches in gapped BLAST to cytidine deaminase: residues 4-127 are 75% similar to the protein in S.pyogenes (gi|15675193|).Residues 4-127 are 70% similar to the protein from S.pneumoniae (gi|15900731|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0953 (2e-51).","

InterPro
IPR002125
Domain

CMP/dCMP deaminase, zinc-binding
PF00383	$\"[1-106]T$	dCMP_cyt_deam_1
PS00903	$\"[52-92]?$	CYT_DCMP_DEAMINASES

InterPro
IPR006262
Family

Cytidine deaminase, homotetrameric
PIRSF001250	$\"[1-128]T$	Cytidine deaminase
PTHR11644:SF2	$\"[8-124]T$	CYTIDINE DEAMINASE
TIGR01354	$\"[3-127]T$	cyt_deam_tetra: cytidine deaminase

noIPR
unintegrated

unintegrated
G3DSA:3.40.140.10	$\"[4-124]T$	no description
PTHR11644	$\"[8-124]T$	CYTIDINE DEAMINASE

","BeTs to 7 clades of COG0295COG name: Cytidine deaminaseFunctional Class: FThe phylogenetic pattern of COG0295 is ----y-v-ebrh--gpo----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 25-124 are 28% similar to a (DEAMINASE CYTIDINE RESISTANCE ZINC) protein domain (PD415104) which is seen in Q9KYT5_STRCO.Residues 11-125 are 62% similar to a (CYTIDINE DEAMINASE HYDROLASE PROTEOME) protein domain (PD003466) which is seen in Q9CFM8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 09:30:37 2002","Thu Feb 7 09:29:36 2002","Tue Oct 15 12:56:29 2002","Thu Feb 7 09:29:36 2002","","Thu Feb 7 09:29:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1025 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 7 09:30:37 2002","","No significant hits to the NCBI PDB database.","SMU.1122c","","Residues 2 to 106 (E-value = 1.4e-21) place SMu1025 in the dCMP_cyt_deam family which is described as Cytidine and deoxycytidylate deaminase zinc-binding region (PF00383)","Thu Feb 7 09:29:36 2002","","","","Ireton GC, McDermott G, Black ME, Stoddard BL.The Structure of Escherichia coli Cytosine Deaminase.J Mol Biol. 2002 Jan 25;315(4):687-697.PMID: 11812140 Mejlhede N, Neuhard J.The role of zinc in Bacillus subtilis cytidine deaminase.Biochemistry. 2000 Jul 11;39(27):7984-9.PMID: 10891079Carlow DC, Carter CW Jr, Mejlhede N, Neuhard J, Wolfenden R.Cytidine deaminases from B. subtilis and E. coli: compensating effects of changing zinc coordination and quaternary structure.Biochemistry. 1999 Sep 21;38(38):12258-65.PMID: 10493793Song BH, Neuhard J.Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase.Mol Gen Genet. 1989 Apr;216(2-3):462-8.PMID: 2526291 ","","Thu Feb 7 09:38:37 2002","1","","","SMU.1122c","927" "SMu1026","1066227","1065565","663","ATGAAAATCAATCAATATATTGACCATACTTTATTAAAACCAGAAAGTAGGCAAGATCAGATTGATAAACTGATTCGAGAAGCTAAGACATATAATTTTGCCAGTGTCTGTATCAATCCAACTTGGGTTTCTTATGCGGCTAAAGCTCTTGAAGGAACAGACATTAAAGTTTGTACTGTTATTGGTTTTCCTTTAGGAGCAACGACTAGTGCTGTAAAAGCCTTTGAAACCAAGGATGCTATTAGTCATGGAGCTGACGAAGTTGATATGGTTATCAATATTGGTCAAGCTAAATCTGGTCATTTTGCTTTTGTTGAAGAAGATATTCGGGCAGTTGTTGAAGCCAGTGGTGACAAATTGGTGAAAGTTATTATTGAAACTTGTCTCCTTACAGATAAAGAAAAAATTAAAGCTTGTCAAGCTGCAGTAGCAGCAGGTGCTGATTTCGTTAAAACATCAACTGGTTTTTCAACTGCTGGAGCTAGGTTAGATGATGTTCGTCTTATGCGTCAAACGGTAGGACCTGATGTTGGAGTAAAGGCGGCAGGAGGAACGCGATCTTTAGAAGATGCGCAAGCTTTTATTGAAGCAGGTGCAACACGTATTGGGACATCTGCTGGAGTTACTATTATGGAAGGAAAGCAAACAAACAGTGGTTATTGA","5.80","-2.46","23349","MKINQYIDHTLLKPESRQDQIDKLIREAKTYNFASVCINPTWVSYAAKALEGTDIKVCTVIGFPLGATTSAVKAFETKDAISHGADEVDMVINIGQAKSGHFAFVEEDIRAVVEASGDKLVKVIIETCLLTDKEKIKACQAAVAAGADFVKTSTGFSTAGARLDDVRLMRQTVGPDVGVKAAGGTRSLEDAQAFIEAGATRIGTSAGVTIMEGKQTNSGY","1065579","For other 'deo' genes see SMu1122 (deod) and SMu1128 (deoB).","deoxyribose-phosphate aldolase","Cytoplasm","Matches in gapped BLAST to deoxyribose-phosphate aldolase:residues 1-220 are 96% similar to the previously published enzyme in S.mutans (gi13507049). Residues 1-220 are 72% similar to the enzyme in S.pneumoniae(gi15902789) and are 66% similar to the enzyme in Lactococcus lactis (gi15673422).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2070 (2e-53).","

InterPro
IPR002915
Family

Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase
PF01791	$\"[2-213]T$	DeoC

InterPro
IPR011343
Family

Deoxyribose-phosphate aldolase
PIRSF001357	$\"[1-220]T$	Deoxyribose-phosphate aldolase
PTHR10889	$\"[1-212]T$	DEOXYRIBOSE-PHOSPHATE ALDOLASE
TIGR00126	$\"[2-212]T$	deoC: deoxyribose-phosphate aldolase

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-220]T$	no description

","BeTs to 9 clades of COG0274COG name: Deoxyribose-phosphate aldolaseFunctional Class: FThe phylogenetic pattern of COG0274 is --t--qvcebrh--gp-l---Number of proteins in this genome belonging to this COG is 1","***** IPB002915 (Deoxyribose-phosphate aldolase) with a combined E-value of 5.2e-35. IPB002915A 8-28 IPB002915B 58-91 IPB002915C 179-205","Residues 27-213 are 71% similar to a (DEOXYRIBOSE-PHOSPHATE ALDOLASE LYASE) protein domain (PD005801) which is seen in DEOC_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 21 08:10:49 2006","Thu Feb 7 09:44:28 2002","Thu Sep 21 08:10:49 2006","Thu Feb 7 09:43:11 2002","Thu Feb 7 09:43:11 2002","Thu Feb 7 09:43:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1026 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 7 09:43:11 2002","","No significant hits to the NCBI PDB database.","SMU.1123c","","Residues 1 to 212 (E-value = 2e-109) place SMu1026 in the DeoC family which is described as Deoxyribose-phosphate aldolase (PF01791)","Thu Feb 7 09:43:11 2002","","","","","Thu Sep 21 08:10:49 2006","","1","","","SMU.1123c","983" "SMu1027","1067523","1066246","1278","ATGAGAGCAGTTGATTTAATTCAGAAAAAACGTGATGGGCTGACATTGACACAGGAAGAAATTTCTTGGCTTATTGAAGGATATGTTAATGGCCAAGTTCCTGATTATCAAATGTCAGCACTTGCTATGGCTATCTATTTTAAAGGAATGAGCACTAGAGAGACGCAAGATTTGACCATGGCTATGGTTAAGTCTGGTCAACAAATTGATTTATCAACTATTGCCGGAATAAAGGTTGATAAACATTCCACAGGTGGTGTTGGTGATAAGGTCACCTTAATTTTAGTACCGCTAGTAGCCAGTTTTGGAGTGCCGGTTGCTAAAATGAGCGGTCGCGGACTGGGACATACTGGCGGAACCCTTGATAAATTGGAATCAATCAAGGGTTATCAGGTCGAGCGTTCACAGGCAGATTTCATTAAGCAGGTCCAAGATATTGGCTTGGCGGTTATTGGTCAGTCTAATGATTTGGTCAAAGCCGATAAATTACTCTATGCCTTGCGTGACGTCACAGCAACAGTTGATACAATGCCCTTGATTGCTAGTTCGATTATGAGCAAGAAAATTGCCGCAGGGGCGGATCGTATTTTATTAGATGTGACAGTGGGTGATGGTGCTTTTATGAAAACTTTAAAAGAAGCTGAAGATTTATCTCAAACCATGGTTAATTTAGGTAAAGAAGTGGGGCGTCAGACCATTGCTGCCATTACAGATATGAGTCAACCTTTGGGACAAGCTATCGGCAATCGCTTAGAAGTTTTAGAAGCCTTACAAATTATGCAGGGGAAAGGCCGTAAGGATATTACTGATTTTATTTGTCAGCTGGCTCAATTACTTTTAGAATTGGCAGGACAAAAGAGAAGTCTGACTGAAATCAAGGAACATTTGATCAATGGACAGGCCCTTCAAAAATTTGAAGACATGGTTACTTATCAAGGTGGTGACTTAAACGATCTCTATCGTCCTTCAGCTGCAAAATTTGTGACCAAGATTCTTGCTGATAAAAATGGTTATATCAAGGAATTACCTGCTTTAGCTTTTGGACTTTTTGCTATGCGTCTGGGAGCTGGACGAGCAGTTAAAACGGATCAACTTGACTATGAGACAGGAATCGTTTTTTATAGAAAAGTCGGTGATCTAATCCAAAAGGGTGACTTACTAGCAGAGATTTATTCCAATGAAAAATTATCGGAAAACTTACTTACAGAATTCAAAAAAAATGTTAAAATAGATAAGGAAGAAATGAAAGTAACTGAAATTTTAAAAATCATTACTTGA","6.40","-1.29","46517","MRAVDLIQKKRDGLTLTQEEISWLIEGYVNGQVPDYQMSALAMAIYFKGMSTRETQDLTMAMVKSGQQIDLSTIAGIKVDKHSTGGVGDKVTLILVPLVASFGVPVAKMSGRGLGHTGGTLDKLESIKGYQVERSQADFIKQVQDIGLAVIGQSNDLVKADKLLYALRDVTATVDTMPLIASSIMSKKIAAGADRILLDVTVGDGAFMKTLKEAEDLSQTMVNLGKEVGRQTIAAITDMSQPLGQAIGNRLEVLEALQIMQGKGRKDITDFICQLAQLLLELAGQKRSLTEIKEHLINGQALQKFEDMVTYQGGDLNDLYRPSAAKFVTKILADKNGYIKELPALAFGLFAMRLGAGRAVKTDQLDYETGIVFYRKVGDLIQKGDLLAEIYSNEKLSENLLTEFKKNVKIDKEEMKVTEILKIIT","1066260","","pyrimidine-nucleoside phosphorylase","Cytoplasm","Several matches in gapped BLAST to pyrimidine nucleoside phosphorylase: residues 1-425 are 71% similar to the enzyme in S.pneumoniae (gi|15902788|) and residues 2-424 are 61% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673424|).SMu1027 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000053
Family

Pyrimidine-nucleoside phosphorylase
PIRSF000478	$\"[1-425]T$	TP_PyNP
PTHR10515	$\"[1-424]T$	Pyrmidine_PPase
TIGR02644	$\"[3-411]T$	Y_phosphoryl
PS00647	$\"[110-125]T$	THYMID_PHOSPHORYLASE

InterPro
IPR000312
Domain

Glycosyl transferase, family 3
PD001864	$\"[76-258]T$	Glyco_trans_3
G3DSA:3.40.1030.10	$\"[67-344]T$	Glyco_trans_3
PF00591	$\"[75-326]T$	Glycos_transf_3
PF02885	$\"[2-67]T$	Glycos_trans_3N

InterPro
IPR013102
Domain

Pyrimidine nucleoside phosphorylase, C-terminal
PF07831	$\"[338-411]T$	PYNP_C

noIPR
unintegrated

unintegrated
SSF47648	$\"[1-70]T$	SSF47648
SSF52418	$\"[68-327]T$	SSF52418
SSF54680	$\"[324-425]T$	SSF54680

","BeTs to 8 clades of COG0213COG name: Thymidine phosphorylaseFunctional Class: FThe phylogenetic pattern of COG0213 is Am-k--v-ebr---gp-----Number of proteins in this genome belonging to this COG is 1","***** IPB000053 (Thymidine/pyrimidine-nucleoside phosphorylase) with a combined E-value of 3.3e-148. IPB000053A 6-34 IPB000053B 37-67 IPB000053C 79-96 IPB000053D 97-127 IPB000053E 150-201 IPB000053F 236-257 IPB000053G 295-315 IPB000053H 354-363***** IPB000312 (Glycosyl transferase family) with a combined E-value of 2.4e-24. IPB000312A 83-129 IPB000312B 214-256 IPB000312B 221-263","Residues 7-151 are 24% similar to a (ANTHRANILATE TRANSFERASE) protein domain (PD001864) which is seen in TRPD_SYNY3.Residues 4-410 are 62% similar to a (PHOSPHORYLASE THYMIDINE PROTEOME COMPLETE) protein domain (PD005916) which is seen in Q9CFM5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 09:57:48 2002","Thu Feb 7 09:56:26 2002","Tue Oct 15 12:58:33 2002","Thu Feb 7 09:56:26 2002","Thu Feb 7 09:56:26 2002","Thu Feb 7 09:56:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1027 is paralogously related (blast p-value < 1e-3) to SMu0485, a predicted anthranilate phosphoribosyltransferase.","Thu Feb 7 10:31:53 2002","Thu Feb 7 09:56:26 2002","pdb|1BRW|B Chain B, The Crystal Structure Of Pyrimidine Nucleos... 440 2e-124pdb|2TPT| Structural And Theoretical Studies Suggest Domain ... 279 5e-076","SMU.1124c","","Residues 3 to 67 (E-value = 9.3e-22) place SMu1027 in the Glycos_trans_3N family which is described as Glycosyl transferase family, helical bundle domain (PF02885)Residues 75 to 302 (E-value = 2.4e-45) place SMu1027 in the Glycos_transf_3 family which is described as Glycosyl transferase family, a/b domain (PF00591)","Thu Feb 7 09:56:26 2002","","","","","","","1","","","SMU.1124c","" "SMu1028","1068228","1067632","597","ATGAATAATATGTACTATACAGAAAATCCCGATAGTAAACACGATATTAGAAAAATAAAGGTTGAATTACTGGGACAGTCTTTTCATTTTTTAACAGATTCAGGTGTTTTTAGTAAAAACATGATTGACTATGGCAGTCAGACTCTTTTAAACAGCCTTGATTTTGCTGAGGAAAAAACATTATTAGATCTCGGCTGTGGCTATGGACCGCTTGGCATTGCCTTGGCTAAGGTTCAAAAACTTGACGTTACTATGGTTGATATTAATAACCGTGCTCTTGATTTAACCCGTCAAAATGCTGAAAATAATGAAGTATCTGCTAATATTTTCCAATCTGATATTTATGAAAATGTTTTTGATAGTTTTGATTATATTATTAGCAATCCGCCCATTAGGGCTGGTAAGAAAGTTGTCCACACTATTATTGAGGGAAGTATTAATCATTTAAAAGAAAATGGCAGTTTGACTATTGTCATCCAAAAAAAGCAAGGTGCTCCTAGTGCTAAAAACAAGATGGAAAATGTTTTTGGCAATGCGATTGTTTTAAAAAGGGATAAGGGATATTATGTTCTTAGAAGTGTGAAAGAAGGAGATTGA","6.50","-1.09","22150","MNNMYYTENPDSKHDIRKIKVELLGQSFHFLTDSGVFSKNMIDYGSQTLLNSLDFAEEKTLLDLGCGYGPLGIALAKVQKLDVTMVDINNRALDLTRQNAENNEVSANIFQSDIYENVFDSFDYIISNPPIRAGKKVVHTIIEGSINHLKENGSLTIVIQKKQGAPSAKNKMENVFGNAIVLKRDKGYYVLRSVKEGD","1067646","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypotheticalproteins: residues 1-196 are 68% similar to S.pyogenes (gi|15675194|) and 65% similar to S.pneumoniae (gi|15902787|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0952 (9e-76).","

InterPro
IPR002296
Family

N6 adenine-specific DNA methyltransferase, N12 class
PR00507	$\"[61-75]T$ $\"[122-134]T$ $\"[136-160]T$	N12N6MTFRASE

InterPro
IPR007848
Domain

Methyltransferase small
PF05175	$\"[27-192]T$	MTS

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[6-196]T$	G3DSA:3.40.50.150
PTHR18895	$\"[44-195]T$	PTHR18895
PTHR18895:SF6	$\"[44-195]T$	PTHR18895:SF6
SSF53335	$\"[6-195]T$	SSF53335

","BeTs to 12 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","***** PR00507 (N12 class N6 adenine-specific DNA methyltransferase signature) with a combined E-value of 1.6e-07. PR00507B 61-75 PR00507C 122-134 PR00507D 136-160","Residues 57-130 are 41% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD015912) which is seen in Y928_METJA.Residues 62-105 are 68% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME ARGININE) protein domain (PD006760) which is seen in Q9CFM4_LACLA.Residues 3-52 are 62% similar to a (PROTEOME COMPLETE BH0124 YOGG) protein domain (PD009478) which is seen in Q9CFM4_LACLA.Residues 126-195 are 68% similar to a (PROTEOME COMPLETE METHYLTRANSFERASE) protein domain (PD088293) which is seen in Q9CFM4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 11 09:22:14 2002","Mon Feb 11 09:22:14 2002","Mon Feb 11 09:22:14 2002","Mon Feb 11 09:22:14 2002","Mon Feb 11 09:22:14 2002","Mon Feb 11 09:22:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1028 is paralogously related (blast p-value < 1e-3) to SMu0992, a predicted protoporphyrinogen oxidase; SMu1619,a predicted RNA methyltransferase (TrmA family); and SMu1497, a predicted tellurite resistance protein.","Mon Feb 11 09:22:14 2002","Mon Feb 11 09:22:14 2002","pdb|1DUS|A Chain A, Mj0882-A Hypothetical Protein From M. Janna... 151 5e-038","SMU.1125c","","Residues 142 to 195 (E-value = 1.7e-20) place SMu1028 in the MTS family which is described as Methyltransferase small domain (PF05175)","Mon Feb 11 09:22:14 2002","24379557","","","","","","1","","","SMU.1125c","672" "SMu1029","1068324","1069244","921","ATGGCAAACGAGTTTATTAATTTTGAAAAAATTTCCCGTAAAACTTGGCAGCACTTGCATCAAGAATCACAACCACCTTTAAATGAAAATGAATTAAATTCCATTAAAAGTCTCAACGATAGAATAAGCATTAAAGATGTGACTGACATTTATTTACCGCTTATTAGCTTGATTCAAATTTATAAAAAATCTCAAGAAAATCTTTCTTTTTCTAAAAGTATTTTCTTACAAAAAAATATCAGCAACCGCCCTTTCATCATCGGAGTATCTGGTTCCGTTGCTGTAGGAAAATCAACAACCAGTCGGCTTTTACAATTACTGTTAGCCAGAACTTTTAAGGACTCTAGTGTTGAATTGATGACAACAGATGGTTTTTTATATCCTAATGCTGTTTTATCTTCAAGGCATATGTTGAATAAAAAAGGTTTCCCTGAAAGTTATGATATGGAACGTCTATTAGACTTTTTAGATACTATTAAAAATGGCCAGTCTGCTGAAATTCCTGTTTATTCACACGAAATTTACGATATTGTACCGAACAAAAGTCAAATAATTGAAGTACCTGACTTTCTTATCATAGAAGGAATTAATGTTTTTCAAAACCCTCAGAATAATCGTCTTTATATGAGTGATTTTTTTGATTTCTCTATTTACATCGATGCTGACAGTGACTATATTGAGAATTGGTATCTAGAGCGCTTTGCAACCCTGCTTGATTTAGCTAAAAATGATAAGCAAAATTACTACAATCGTTTCTTAAAATTAGGGGAAAAAGGTGCTCTTGACTTTGCCAGAGACATTTGGAAAGATATTAATTTAGTTAATCTAGAAAAATATATTGAACCGACACGAAGCCGTGCTGAGCTTATTCTTCATAAGACTAAAAATCATAAAATAGATGAAATTTACCTTAAAAAGTGA","6.50","-1.54","35724","MANEFINFEKISRKTWQHLHQESQPPLNENELNSIKSLNDRISIKDVTDIYLPLISLIQIYKKSQENLSFSKSIFLQKNISNRPFIIGVSGSVAVGKSTTSRLLQLLLARTFKDSSVELMTTDGFLYPNAVLSSRHMLNKKGFPESYDMERLLDFLDTIKNGQSAEIPVYSHEIYDIVPNKSQIIEVPDFLIIEGINVFQNPQNNRLYMSDFFDFSIYIDADSDYIENWYLERFATLLDLAKNDKQNYYNRFLKLGEKGALDFARDIWKDINLVNLEKYIEPTRSRAELILHKTKNHKIDEIYLKK","1069252","","pantothenate kinase","Cytoplasm","Several matches in gapped BLAST to pantothenate kinase: residues 1-306 are 70% similar to the enzyme in S.pyogenes (gi15675195)and are 66% similar to the protein from S.pneumoniae(gi15902785).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0951 (1e-128).","

InterPro
IPR004566
Family

Bacterial pantothenate kinase
PIRSF000545	$\"[2-306]T$	Pantothenate_kin
TIGR00554	$\"[6-306]T$	panK_bact

InterPro
IPR006083
Family

Phosphoribulokinase/uridine kinase
PF00485	$\"[86-300]T$	PRK

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[5-306]T$	G3DSA:3.40.50.300
PTHR10285	$\"[92-297]T$	PTHR10285
PTHR10285:SF7	$\"[92-297]T$	PTHR10285:SF7
SSF52540	$\"[2-306]T$	SSF52540

","BeTs to 3 clades of COG1072COG name: Panthothenate kinaseFunctional Class: HThe phylogenetic pattern of COG1072 is --------Ebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001324 (Phosphoribulokinase family) with a combined E-value of 6.8e-06. IPB001324A 83-104 IPB001324C 186-197***** PR00988 (Uridine kinase signature) with a combined E-value of 9.5e-06. PR00988A 84-101 PR00988C 162-177 PR00988F 279-292","Residues 12-61 are 60% similar to a (KINASE PANTOTHENATE TRANSFERASE) protein domain (PD015802) which is seen in Q9CFM3_LACLA.Residues 203-306 are 62% similar to a (KINASE PANTOTHENATE TRANSFERASE) protein domain (PD015803) which is seen in Q9CFM3_LACLA.Residues 86-202 are 54% similar to a (KINASE URIDINE TRANSFERASE ATP-BINDING) protein domain (PD003288) which is seen in COAA_BACSU.Residues 86-200 are 65% similar to a (KINASE PANTOTHENATE TRANSFERASE) protein domain (PD117381) which is seen in Q9CFM3_LACLA.Residues 76-233 are 26% similar to a (PROTEOME COMPLETE FRCK BH0320) protein domain (PD310746) which is seen in Q9F9A9_RHIME.Residues 83-233 are 23% similar to a (ATP-BINDING TRANSFERASE F10O3.15 EPD-CMTA) protein domain (PD277535) which is seen in YGGC_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 11 09:26:12 2002","Mon Sep 11 16:07:20 2006","Tue Jul 5 10:33:12 2005","Mon Feb 11 09:25:01 2002","Mon Feb 11 09:25:01 2002","Mon Feb 11 09:25:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1029 is paralogously related (blast p-value < 1e-3) to SMu1263, a predicted uridine kinase.","Mon Feb 11 10:50:53 2002","Tue Jul 5 10:33:12 2005","pdb1ESMA Chain A, Structural Basis For The Feedback Regulatio... 255 5e-069","SMU.1126","","Residues 86 to 300 (E-value = 5.7e-07) place SMu1029 in the PRK family which is described as Phosphoribulokinase / Uridine kinase family (PF00485)","Mon Feb 11 09:25:01 2002","24379558","","Wang B, Kuramitsu HK.Inducible antisense RNA expression in the characterization of gene functions in Streptococcus mutans.Infect Immun. 2005 Jun;73(6):3568-76.PMID: 15908386","Yun M, Park CG, Kim JY, Rock CO, Jackowski S, Park HW.Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.J Biol Chem. 2000 Sep 8;275(36):28093-9.PMID: 10862768 Song WJ, Jackowski S.Kinetics and regulation of pantothenate kinase from Escherichia coli.J Biol Chem. 1994 Oct 28;269(43):27051-8.PMID: 7929447 Song WJ, Jackowski S.Kinetics and regulation of pantothenate kinase from Escherichia coli.J Biol Chem. 1994 Oct 28;269(43):27051-8.PMID: 7929447 ","Mon Sep 11 16:07:20 2006","Mon Feb 11 10:04:54 2002","1","","","SMU.1126","343" "SMu1030","1069298","1069552","255","ATGGAGGTAATAAAGACATTGGCAAATATTAAATCAGCTATTAAACGTGCTGAACTTAACGTTAAACAAAATAACCGCAATTCAGCTCAAAAATCAGCTATGCGTTCAGCTATTAAAGCTTTTGAAGCAAATCCTAATGAAGAGCTTTTCCGCGCTGCTTCTTCAAGTATCGACAAAGCTAAATCAAAAGGTTTGATTCACAAAAATAAGGCAAGCCGCGATAAAGCACGTCTTGCAAGCAAATTAGCCAAATAA","11.50","13.22","9220","MEVIKTLANIKSAIKRAELNVKQNNRNSAQKSAMRSAIKAFEANPNEELFRAASSSIDKAKSKGLIHKNKASRDKARLASKLAK","1069560","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1841 (rps10);SMu1838 (rps19); SMu0322 (rpsL); SMu0323 (rpsG); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).","30S ribosomal protein S20","Periplasm, Cytoplasm","Several matches in gapped BLAST to 30S ribosomal protein subunit S20: residues 4-84 are 75% similar to the protein in S.pneumoniae (gi|15902784|).Residues 7-82 are 75% similar to the protein from S.pyogenes (gi|15675196|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0950 (1e-28).","

InterPro
IPR002583
Family

Ribosomal protein S20
PD004231	$\"[23-84]T$	RS20_LISMO_Q92BN3;
G3DSA:1.20.58.110	$\"[2-83]T$	no description
PF01649	$\"[8-84]T$	Ribosomal_S20p
TIGR00029	$\"[7-84]T$	S20: ribosomal protein S20

","BeTs to 9 clades of COG0268COG name: Ribosomal protein S20Functional Class: JThe phylogenetic pattern of COG0268 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002583 (Ribosomal protein S20) with a combined E-value of 1.2e-28. IPB002583A 7-40 IPB002583B 57-78 IPB002583A 11-44","Residues 8-82 are 65% similar to a (RIBOSOMAL 30S RRNA-BINDING PROTEOME) protein domain (PD004231) which is seen in Q9CEU5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 13:01:33 2002","Mon Feb 11 10:10:45 2002","Tue Oct 15 13:01:33 2002","Mon Feb 11 10:10:45 2002","Mon Feb 11 10:10:45 2002","Mon Feb 11 10:10:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1030 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 11 10:10:45 2002","Mon Feb 11 10:10:45 2002","pdb|1FJF|T Chain T, Structure Of The Thermus Thermophilus 30s R... 85 1e-018","SMU.1127","","Residues 8 to 84 (E-value = 1.3e-20) place SMu1030 in the Ribosomal_S20p family which is described as Ribosomal protein S20 (PF01649)","Mon Feb 11 10:10:45 2002","161486822","","","Osawa S.Gene locus of a 30s ribosomal protein S20 of Bacillus subtilis.Mol Gen Genet. 1976 Feb 27;144(1):49-51.PMID: 817126 ","","Mon Feb 11 10:14:27 2002","1","","","SMU.1127","926" "SMu1031","1070949","1069642","1308","ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAATATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAGCAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCCTCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAATAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTAAGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTTGCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGTTTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGCAAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTTCGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCTGACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTGATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTATCAATAAGGTCAACCGTCAAATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGGGGAAATTTGGCTGGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACGAGGATAAGAAGAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGTTTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTTTGAAGCTCGCCTGCTTGCTAATAAATAA","10.00","9.71","49857","MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDASFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKFATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLFRKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHIINKVNRQIKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLGLSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK","1069656","For other 'kin' genes see SMu0842 (kinF) and SMu0919 (kinG).For other 'cov' genes see SMu1377 (covX); SMu1047 (covS); SMu1048 (covR); SMu1378 (covS) and SMu1379 (covR).For other 'cia' genes see SMu1032 (ciaR).","two-component sensor histidine kinase","Membrane, Cytoplasm","Matches in gapped BLAST to histidine kinase protein:residues 213-427 are 35% similar to the previously published sensor protein CovS in S.mutans (gi14600272). Residues 4-431 are 57% similar to histidine kinase protein inS.pyogenes (gi15675197) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0984 (1e-146).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[290-431]T$	ATP_bd_ATPase
PF02518	$\"[323-434]T$	HATPase_c
SM00387	$\"[323-435]T$	HATPase_c
SSF55874	$\"[269-431]T$	ATP_bd_ATPase

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[213-280]T$	HisKA
SM00388	$\"[213-280]T$	HisKA

InterPro
IPR004358
Domain

Histidine kinase related protein, C-terminal
PR00344	$\"[360-374]T$ $\"[378-388]T$ $\"[395-413]T$	BCTRLSENSOR

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[220-435]T$	HIS_KIN

InterPro
IPR008358
Family

Lantibiotic regulatory protein
PR01780	$\"[222-238]T$ $\"[362-378]T$ $\"[383-398]T$	LANTIREGPROT

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[203-276]T$	His_kin_homodim

noIPR
unintegrated

unintegrated
G3DSA:1.10.287.240	$\"[203-276]T$	G3DSA:1.10.287.240
PTHR23283	$\"[1-7]T$ $\"[203-431]T$	PTHR23283
PTHR23283:SF34	$\"[1-7]T$ $\"[203-431]T$	PTHR23283:SF34

","BeTs to 12 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","***** PR00344 (Bacterial sensor protein C-terminal signature) with a combined E-value of 1.9e-13. PR00344A 360-374 PR00344B 378-388 PR00344C 395-413***** IPB003661 (His Kinase A domain) with a combined E-value of 1.5e-08. IPB003661A 221-230 IPB003661B 334-343 IPB003661C 364-372","Residues 39-207 are 34% similar to a (KINASE TRANSDUCTION TRANSFERASE) protein domain (PD111118) which is seen in CIAH_STRPN.Residues 303-385 are 38% similar to a (TRANSFERASE PHOSPHORYLATION RPRX KINASE) protein domain (PD126133) which is seen in Q08408_BACFR.Residues 210-276 are 43% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD150714) which is seen in Q9RPY9_LISMO.Residues 327-415 are 34% similar to a (TRANSDUCTION TRANSFERASE PHOSPHORYLATION) protein domain (PD404615) which is seen in SPAK_BACSU.Residues 318-384 are 37% similar to a (TRANSFERASE PHOSPHORYLATION KINASE) protein domain (PD251328) which is seen in Q9KJN3_STAAU.Residues 328-384 are 68% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD371767) which is seen in Q9CF07_LACLA.Residues 324-424 are 31% similar to a (KINASE TRANSDUCTION TRANSFERASE SENSORY) protein domain (PD036888) which is seen in YXDK_BACSU.Residues 217-306 are 82% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD000142) which is seen in CIAH_STRPN.Residues 385-428 are 79% similar to a (KINASE SENSORY TRANSDUCTION) protein domain (PD000064) which is seen in CIAH_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 11:04:59 2006","Wed Aug 30 11:04:59 2006","Tue Feb 1 11:59:18 2005","Mon Feb 11 10:54:35 2002","Tue Jan 8 11:53:36 2002","Tue Jan 8 11:53:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1031 is paralogously related (blast p-value < 1e-3) to SMu1378, SMu0842, SMu1652, SMu0919, SMu0602, SMu0946, SMu1047,all predicted histidine kinases and SMu1752, a predicted protein secretion ABC transport permease.","Mon Feb 11 11:02:23 2002","","No significant hits to the NCBI PDB database.","SMU.1128c","","Residues 213 to 280 (E-value = 5.9e-11) place SMu1031 in the HisKA family which is described as His Kinase A (phosphoacceptor) domain (PF00512)Residues 323 to 434 (E-value = 3e-34) place SMu1031 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Tue Feb 1 11:59:18 2005","",""," Ahn SJ, Wen ZT, Burne RA.Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159.Infect Immun. 2006 Mar;74(3):1631-42.PMID: 16495534Lee SF, Delaney GD, Elkhateeb M.A two-component covRS regulatory system regulates expression of fructosyltransferase and a novel extracellular carbohydrate in Streptococcus mutans.Infect Immun. 2004 Jul;72(7):3968-73.PMID: 15213141Qi F, Merritt J, Lux R, Shi W.Inactivation of the ciaH Gene in Streptococcus mutans diminishes mutacin production and competence development, alters sucrose-dependent biofilm formation, and reduces stress tolerance.Infect Immun. 2004 Aug;72(8):4895-9.PMID: 15271957","Guenzi,E., Gasc,A.M., Sicard,M.A. and Hakenbeck,R.A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants ofStreptococcus pneumoniaeMol. Microbiol. 12 (3), 505-515 (1994)PubMed: 8065267","Thu Feb 3 15:26:04 2005","Mon Feb 11 10:57:15 2002","1","","","SMU.1128c","557" "SMu1032","1071613","1070939","675","ATGATAAAGTTATTATTAGTAGAAGACGATTTGAGTCTATCTAACTCTATCTTTGACTTTCTGGATGATTTTGCTGATGTCATGCAGGTTTTTGATGGTGAAGAAGGACTGTATGAAGCAGAGAGTGGCGTTTATGATTTGATTCTATTAGACTTAATGCTTCCTGAAAAAAATGGCTTCCAAGTTTTAAAAGAACTGCGTGAAAAAGGGATAACGACACCTGTTTTGATTATGACAGCTAAGGAAGGTTTGGATGACAAAGGACACGGTTTTGAATTAGGAGCTGATGATTATCTGACAAAACCATTTTATCTTGAAGAATTAAAAATGCGTATTCAGGCCCTCCTCAAACGTTCAGGCAAATTCAACGAAAATAATCTGACTTACGGTGAGTTAACCGTTGATACAGCAACTAATACAACAATGGTAAATGGAAAAGAAGTTGAACTGCTTGGCAAAGAGTTTGACTTATTAGTTTATTTCTTACAAAATCAAAATGTCATTTTACCTAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGCGATACGACAATTTCGGTTGTTGAAGTCTATGTTTCTAAAATAAGAAAGAAATTAAAAGACACCACATTTGGAAAGAATTTACAGACATTACGCAGTGTAGGATATATTTTGAAGGATGCTAATTAA","4.40","-12.74","25461","MIKLLLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLTYGELTVDTATNTTMVNGKEVELLGKEFDLLVYFLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFGKNLQTLRSVGYILKDAN","1070953","For other 'cia' genes see SMu1032 (ciaR).","two-component response regulator","Cytoplasm","Matches in gapped BLAST to DNA-binding response regulator:residues 4-224 are 34% similar to the previously published gcrR in S.mutans(gi6174678). Residues 1-222 are 89% similar to DNA-binding response regulator in S.pneumoniae (gi15902751) and are 85% similar to the protein from S.pyogenes (gi15675198). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0985 (1e-111).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[2-116]T$	Response_reg
PF00072	$\"[2-113]T$	Response_reg
SM00448	$\"[2-112]T$	REC
PS50110	$\"[3-116]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[143-218]T$	Trans_reg_C
PF00486	$\"[145-220]T$	Trans_reg_C

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-178]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[2-152]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[3-121]T$	PTHR23283
PTHR23283:SF21	$\"[3-121]T$	PTHR23283:SF21

","BeTs to 8 clades of COG0745COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG0745 is -----QVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 10","***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 6.8e-47. IPB001867A 46-59 IPB001867B 74-118 IPB001867C 148-179 IPB001867D 206-220***** IPB001789 (Response regulator receiver domain) with a combined E-value of 7.9e-15. IPB001789A 5-11 IPB001789B 46-59 IPB001789C 94-103","Residues 2-116 are 96% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in Q9S1K3_STRPN.Residues 127-220 are 79% similar to a (DNA-BINDING TRANSDUCTION SENSORY TRANSCRIPTION) protein domain (PD000329) which is seen in Q9S1K3_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 11:05:43 2006","Wed Aug 30 11:05:43 2006","Mon Jul 31 14:31:49 2006","Mon Feb 11 11:08:01 2002","Tue Jan 8 11:54:40 2002","Tue Jan 8 11:54:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1032 is paralogously related (blast p-value < 1e-3) to SMu1748, SMu0841, SMu1379, SMu1048, SMu1653, SMu0947, SMu0601, SMu0918, SMu1406, SMu1782, SMu0525, and SMu0441, all predicted response regulators.","Mon Feb 11 11:14:59 2002","Mon Jul 31 14:31:49 2006","pdb1B00A Chain A, Phob Receiver Domain From Escherichia Coli ... 74 2e-014pdb1A04A Chain A, The Structure Of The NitrateNITRITE RESPON... 69 4e-013","SMU.1129c","","Residues 2 to 120 (E-value = 2.5e-29) place SMu1032 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 145 to 220 (E-value = 1.3e-18) place SMu1032 in the Trans_reg_C family which is described as Transcriptional regulatory protein, C terminal (PF00486)","Mon Jul 31 14:31:49 2006","",""," Ahn SJ, Wen ZT, Burne RA.Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159.Infect Immun. 2006 Mar;74(3):1631-42.PMID: 16495534Sato,Y., Yamamoto,Y. and Kizaki,H.Construction of region-specific partial duplication mutants(merodiploid mutants) to identify the regulatory gene for theglucan-binding protein C gene in vivo in streptococcus mutansFEMS Microbiol. Lett. 186 (2), 187-191 (2000)PubMed: 10802169","Guenzi,E., Gasc,A.M., Sicard,M.A. and Hakenbeck,R.A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants ofStreptococcus pneumoniaeMol. Microbiol. 12 (3), 505-515 (1994)PubMed: 8065267Lange,R., Wagner,C., de Saizieu,A., Flint,N., Molnos,J.,Stieger,M., Caspers,P., Kamber,M., Keck,W. and Amrein,K.E.Domain organization and molecular characterization of 13two-component systems identified by genome sequencing ofStreptococcus pneumoniaeGene 237 (1), 223-234 (1999)PubMed: 10524254","Mon Feb 11 11:10:11 2002","Mon Feb 11 11:09:26 2002","1","","","SMU.1129c","675" "SMu1033","1071927","1071664","264","ATGAAAATTTTTAAATCAAAATGGATGATGGCTTTTTTAGCTATCCTAGGTATGGCACTTTGCTTTTCTGGAGGCTATGCAACAGCAAAATTAACTCAGACGAAGCCTACTATGCCTAAAAATGTCAAAAAAGGTACTCCGCCTAAAGGTGCTCCGGAAGATACTCCACCTAATGGCAATTCAAATGATTCATCGCAATCGGATAGTGATTCCGATTCTAATAGTAGCAATACGAATTCAAATTCTTCCATAACAAATGGCTAG","9.90","2.93","9117","MKIFKSKWMMAFLAILGMALCFSGGYATAKLTQTKPTMPKNVKKGTPPKGAPEDTPPNGNSNDSSQSDSDSDSNSSNTNSNSSITNG","1071678","","hypothetical protein","Extracellular, Periplasm","No significant hit in gapped BLAST found.SMu1033 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-27]?$	signal-peptide
tmhmm	$\"[9-29]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 11 11:20:24 2002","Mon Feb 11 11:20:24 2002","Mon Feb 11 11:20:24 2002","Mon Feb 11 11:20:24 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1033 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 11 11:20:24 2002","","No significant hits to the NCBI PDB database.","SMU.1131c","","No significant hits to the Pfam 11.0 database","Mon Feb 11 11:20:24 2002","24379562","","","","","","1","","","SMU.1131c","" "SMu1034","1074877","1072328","2550","ATGGAAACTGTAGAGCACCTTATTGAAAAGTTTGTACCTGAAAATTATAATATTTTCCTTGATATTAACCGTCAGGAGAAGTTTTTTTCAGGAAATGTTGCTATTAACGGAGAAGCGCTAGATAATGTTATTTCCTTCCATCAGAAGGATTTAACGATTCATTCGGTCCTTTTAGATAATAATGAATTAACTTATCATATTGATAATGAAAATGAGGCTGTTCGGATTGAACTGCCTGAGACAGGCAGTATGACCCTTGTTCTTGAATTTTCAGGTAAGATTACAGACAATATGACAGGAATATATCCTTCTTATTATACGGTTGAAAATGTTAAAAAAGAGATTATTTCAACACAATTTGAAAGTCACTTTGCCCGTGAAGTTTTTCCAAGTATTGATGAACCGGAAGCCAAGGCAACCTTTGATTTAGCTTTGAAATTTGATCAGGAAGAAGGAGACATTGCTCTTTCGAATATGCCAGAGATTAATGCTAATCGTCGTCAAGAAACAGGTGTCTGGACCTTTGAAACAACTCCAAGAATGTCTTCTTATCTGCTGGCTTTTGCCTTAGGTAATCTTCATGGTAAGACGGCCTATACAAAAGGTGGAACAGAAGTAGGTGTTTTTGCAACCTGTGCCCATAATATTGACTCAGTTGATTTTGCTTTAGATATTGCTGTTCGTGTTATTGATTTTTATGAAGATTATTATGGTATTAAGTATCCTATTGCACAGGCTTACCATGTTGCCTTACCGGATTTCTCAGCAGGTGCTATGGAGAACTGGGGATTAATCACTTATCGTGAGGTTTATCTTCTTGTTGATGAAAATTCTACCGTTAGCAGCCGCCAGCAGGTTGCACTTGTTGTTGCCCATGAACTGGCGCATCAATGGTTTGGTAATCTGGTAACTATGAAGTGGTGGGATGACCTTTGGCTGAATGAAAGTTTTGCCAATATGATGGAATATGTTGCTATTGATGCTATTAAACCAAACTGGCATATTTTTGAAGACTTTCAGACCAGCGGTGTTCCTCATGCTTTGAAGCGTGATGCAACTGACGGTGTTCAATCTGTCCATGTCGCAGTTAATCATCCTGATGAAATCAATACACTTTTTGATGCTGCTATTGTCTATGCTAAAGGAAGCCGATTGATGCATATGCTGCGTCGCTGGTTAGGTGACAAAGTTTTTGCTGCTGGACTGAAACTTTACTTTGAAAAGCATCAATACAATAACACTGTTGGGCGTGATCTGTGGAATGCTTTATCAACCGCTTCTGGTAAGGATGTTGCTAGTTTCATGGATGCTTGGCTTGAACAACCGGGCTACCCCTTAGTGACACTTAAACTTGAAGGAGATAGCCTGCAACTATCTCAAAAACAATTTTTCATCGGAGAATATGAGGATCAAGATCGTCTTTGGCCAATTCCTCTTAACAGCAATTGGTCAGGTTTACCGGAAATATTATCGGAAAAAACGATTGAAATTCCTAATTTCAGTCAATTAGCTGCTGTAAATAAAGAAAAAGGACCATTACGCTTAAATACAGATAATACAGCTCATTATATCAGTAATTATGAAGGTCAGCTGTTAAAATCAATTTTATCTGATTTTGAGAATCTTGATAAAACCTCCAAGCTGCAAATTATTCAGGAACGTCGTCTTCTAGCAGAAAGCGGTCAGATTTCTTATGCTGAATTAGTAAAATTGTTAACACAATTATCTCACGAAACGTCTTACATGGTCGCTTCAGCTAGCGATCAATTAATTGCTGGTTTAAAACGATTTTTAGATGAAGACAGCCAATCAGAATCAATGTTTAAAGTTCTTGTTCGTGATGTTTATCGTACGAATTATCAACGCCTAGGTTTTGAAAAGTCCGTGGAGGAAATGGATGAGGACGAAAAGGTTCGTCAAATTACTATTTCTAATATGATTTATGCTGATGATCCTGATGCCAATGAAAAAGCACAAGCGATTTTTGCAAATTATAAGGAAAATATTGAAGCCATTCCAGCCGCTATTCGTCTTGACGTTTTAACGAATCAAATAAAGCATGCCGAAACCGACGATTTAGTAAGTCTTTATTTAGATTCATACGTTAAAACGAATGACAGTAATTTTCGTAGGCAATTGGCCAGTGCTCTGGCAAATACGAAATCACAAATAACACTTGATCGTATTCTAGCTCAATTGCCTAATAGAGATGTTATTAAACCGCAAGATTTGTCATTATGGTATGGACTTTTCTTGAGAAAATCATTTGCACAAGAAACCTTTTGGGCTTGGGCGCGTGAGAATTGGGCTTGGATTAAAGCCACACTTGGTGGTGATATGAGTTTTGATAGTTTTGTAATTATTCCAGCAAATGTCTTTAAGACACCAGAACGTCTGGCAGAATACAAAGCTTTCTTTGAACCTCAATTGGATGATTTATCCATCAGCCGTAATATTACTATGGGAATTAAAGAAATAGCAGCTCGCATAACGCTAATTGAAAAAGAAAAAGCTGCTGTTGAACAAACTATTGTCAATACTTTTTTGTAA","4.70","-41.35","96826","METVEHLIEKFVPENYNIFLDINRQEKFFSGNVAINGEALDNVISFHQKDLTIHSVLLDNNELTYHIDNENEAVRIELPETGSMTLVLEFSGKITDNMTGIYPSYYTVENVKKEIISTQFESHFAREVFPSIDEPEAKATFDLALKFDQEEGDIALSNMPEINANRRQETGVWTFETTPRMSSYLLAFALGNLHGKTAYTKGGTEVGVFATCAHNIDSVDFALDIAVRVIDFYEDYYGIKYPIAQAYHVALPDFSAGAMENWGLITYREVYLLVDENSTVSSRQQVALVVAHELAHQWFGNLVTMKWWDDLWLNESFANMMEYVAIDAIKPNWHIFEDFQTSGVPHALKRDATDGVQSVHVAVNHPDEINTLFDAAIVYAKGSRLMHMLRRWLGDKVFAAGLKLYFEKHQYNNTVGRDLWNALSTASGKDVASFMDAWLEQPGYPLVTLKLEGDSLQLSQKQFFIGEYEDQDRLWPIPLNSNWSGLPEILSEKTIEIPNFSQLAAVNKEKGPLRLNTDNTAHYISNYEGQLLKSILSDFENLDKTSKLQIIQERRLLAESGQISYAELVKLLTQLSHETSYMVASASDQLIAGLKRFLDEDSQSESMFKVLVRDVYRTNYQRLGFEKSVEEMDEDEKVRQITISNMIYADDPDANEKAQAIFANYKENIEAIPAAIRLDVLTNQIKHAETDDLVSLYLDSYVKTNDSNFRRQLASALANTKSQITLDRILAQLPNRDVIKPQDLSLWYGLFLRKSFAQETFWAWARENWAWIKATLGGDMSFDSFVIIPANVFKTPERLAEYKAFFEPQLDDLSISRNITMGIKEIAARITLIEKEKAAVEQTIVNTFL","1072342","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). From Genbank:[gi:2499896]Aminopeptidase with broad substrate specificity to several peptides.It has more affinity for oligopeptides than for dipeptides.It plays an essential role in the metabolism, it may beinvolved in nitrogen supply or protein turnover. ","lysyl-aminopeptidase","Cytoplasm, Extracellular","Several matches in gapped BLAST to aminopeptidase N: residues 3-844 are 69% similar to the enzyme in S.thermophilus (gi5524752). Residues 1-840 are 68% similar to the protein from S.pyogenes (gi15675199).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0986 (0.0).","

InterPro
IPR001930
Family

Peptidase M1, membrane alanine aminopeptidase
PTHR11533	$\"[90-846]T$	Peptidase_M1

InterPro
IPR006025
Binding_site

Peptidase M, neutral zinc metallopeptidases, zinc-binding site
PS00142	$\"[289-298]?$	ZINC_PROTEASE

InterPro
IPR014782
Domain

Peptidase M1, membrane alanine aminopeptidase, N-terminal
PR00756	$\"[126-141]T$ $\"[175-190]T$ $\"[254-264]T$ $\"[289-304]T$ $\"[308-320]T$	ALADIPTASE
PF01433	$\"[7-382]T$	Peptidase_M1

noIPR
unintegrated

unintegrated
SSF55486	$\"[200-449]T$	SSF55486
SSF63737	$\"[11-192]T$	SSF63737

","BeTs to 4 clades of COG0308COG name: Aminopeptidase NFunctional Class: EThe phylogenetic pattern of COG0308 is ----Y--ce-rh---------Number of proteins in this genome belonging to this COG is 1","***** PR00756 (Membrane alanyl dipeptidase (M1) family signature) with a combined E-value of 6e-47. PR00756A 126-141 PR00756B 175-190 PR00756C 254-264 PR00756D 289-304 PR00756E 308-320","Residues 635-778 are 56% similar to a (AMINOPEPTIDASE HYDROLASE METALLOPROTEASE ZINC) protein domain (PD002091) which is seen in Q9X9P5_STRTR.Residues 117-251 are 78% similar to a (AMINOPEPTIDASE HYDROLASE METALLOPROTEASE ZINC) protein domain (PD147002) which is seen in Q9X9P5_STRTR.Residues 3-116 are 69% similar to a (AMINOPEPTIDASE LYS-AP HYDROLASE LYSYL) protein domain (PD401027) which is seen in Q9X9P5_STRTR.Residues 779-844 are 68% similar to a (AMINOPEPTIDASE LYS-AP HYDROLASE LYSYL) protein domain (PD143205) which is seen in Q9X9P5_STRTR.Residues 311-420 are 81% similar to a (AMINOPEPTIDASE HYDROLASE ZINC METALLOPROTEASE) protein domain (PD143214) which is seen in Q9X9P5_STRTR.Residues 430-479 are 60% similar to a (AMINOPEPTIDASE HYDROLASE ZINC METALLOPROTEASE) protein domain (PD342034) which is seen in Q9CIQ1_LACLA.Residues 38-302 are 23% similar to a (V AC3.5 CHROMOSOME TRANSMEMBRANE) protein domain (PD143215) which is seen in Q17405_CAEEL.Residues 513-624 are 27% similar to a (AMINOPEPTIDASE HYDROLASE METALLOPROTEASE ZINC) protein domain (PD312518) which is seen in Q9VD86_DROME.Residues 480-626 are 59% similar to a (AMINOPEPTIDASE LYS-AP HYDROLASE LYSYL) protein domain (PD328142) which is seen in Q9X9P5_STRTR.Residues 427-631 are 23% similar to a (AMINOPEPTIDASE) protein domain (PD312495) which is seen in Q9Z656_ZYMMO.Residues 249-449 are 25% similar to a (CG4467 CG6071) protein domain (PD317666) which is seen in Q9VCP4_DROME.Residues 118-191 are 43% similar to a (AMINOPEPTIDASE LYS-AP PROTEOME COMPLETE) protein domain (PD345792) which is seen in Q9L1Z2_STRCO.Residues 6-251 are 25% similar to a (AMINOPEPTIDASE HYDROLASE PROTEOME) protein domain (PD262965) which is seen in O96935_PLAFA.Residues 252-309 are 38% similar to a (AMINOPEPTIDASE ZINC 3.4.11.-) protein domain (PD385573) which is seen in YIN7_YEAST.Residues 428-563 are 25% similar to a (AMINOPEPTIDASE HYDROLASE 3.4.11.- ZINC) protein domain (PD188528) which is seen in TRF3_THEAC.Residues 118-243 are 26% similar to a (METALLOPROTEASE BG:DS00365.1 ZINC) protein domain (PD346689) which is seen in Q9NK76_DROME.Residues 252-310 are 93% similar to a (AMINOPEPTIDASE HYDROLASE METALLOPROTEASE ZINC) protein domain (PD001134) which is seen in AMPN_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 10:35:19 2006","Mon Feb 11 11:32:08 2002","Thu Aug 3 10:35:19 2006","Mon Feb 11 11:32:08 2002","Mon Feb 11 11:32:08 2002","Mon Feb 11 11:32:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1034 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 11 11:33:09 2002","","No significant hits to the NCBI PDB database.","SMU.1132c","","Residues 7 to 382 (E-value = 1.5e-160) place SMu1034 in the Peptidase_M1 family which is described as Peptidase family M1 (PF01433)","Mon Feb 11 11:32:08 2002","","","","Chavagnat,F., Casey,M.G. and Meyer,J.Purification, characterization, gene cloning, sequencing, andoverexpression of aminopeptidase N from streptococcus thermophilusAppl. Environ. Microbiol. 65 (7), 3001-3007 (1999)PubMed: 10388695","","Thu Mar 21 12:45:01 2002","1","","","SMU.1132c","117" "SMu1035","1075571","1074918","654","ATGTTAAGAACACAATTTGAGGAAGAGTTAGATAAGCTTCACAATCAATTCTACGCTATGGGAACAGAGGTGCTGGCACAGATTAATAAAACAGTTCGCGCTTTTGTCAGCCATGATCGTGATTTGGCAAAAGAAGTTATTGCTGAAGATGATGTTGTCAATGAGTATGAAACGAAACTTGAAAAGAAATCTCTTGAAATTATTGCACTGCAGCAACCTGTTTCTAATGACTTAAGAACAGTAATCACTGTCCTTAAGGCCTCAAGTGACATTGAACGTATGGGGGATCACGCCTCATCTATAGCTAAAGCGACTATTCGAATGAAGGGTGAGGAACGCCTTTTAGATGTTGAAAAGCAAATCAGTGAGATGGGGAAGGCTGTTAAACATATAGTAGAAGATGCTTTGAATGCCTATATTAATGGTGATGACAAAAAGGCTTATGAAATTGCAGCAACAGATGAGATTATTGATAATTACTTTAAAGATATTCAAAATTTAGCTGTTGAAGAAATTAAGAAAGCACCTAATGCGGCTTTTGCAGGAAAAGAATATTTCCAAGTTCTGATGTTTCTTGAACGTATTGGTGATTATGCAAGAAATATCTGTGAATGGATTGTTTATCTTAAAACTGGCAAAATCATTGAATTATGA","4.80","-10.06","24760","MLRTQFEEELDKLHNQFYAMGTEVLAQINKTVRAFVSHDRDLAKEVIAEDDVVNEYETKLEKKSLEIIALQQPVSNDLRTVITVLKASSDIERMGDHASSIAKATIRMKGEERLLDVEKQISEMGKAVKHIVEDALNAYINGDDKKAYEIAATDEIIDNYFKDIQNLAVEEIKKAPNAAFAGKEYFQVLMFLERIGDYARNICEWIVYLKTGKIIEL","1074932","For other 'pho' genes see SMu0946 (phoR) and SMu1474 (phoH).","phosphate uptake regulatory protein","Cytoplasm","Several matches in gapped BLAST to phosphate uptake regulatory protein: residues 1-217 are 85% similar to the protein in S.pyogenes (gi15675200) and are 69% similar to the protein from S.pneumoniae (gi15901249).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0987 (3e-94).","

InterPro
IPR008170
Family

PhoU
PF01895	$\"[17-105]T$ $\"[121-206]T$	PhoU
TIGR02135	$\"[4-215]T$	phoU_full

noIPR
unintegrated

unintegrated
G3DSA:1.20.58.220	$\"[4-114]T$ $\"[120-216]T$	G3DSA:1.20.58.220
PTHR10010	$\"[49-217]T$	PTHR10010
PTHR10010:SF10	$\"[49-217]T$	PTHR10010:SF10
SSF109755	$\"[3-217]T$	SSF109755

","BeTs to 10 clades of COG0704COG name: Phosphate uptake regulatorFunctional Class: PThe phylogenetic pattern of COG0704 is AMTk-qVce-R---gpo----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 5-109 are 73% similar to a (PHOSPHATE TRANSPORT SYSTEM HOMOLOG) protein domain (PD003838) which is seen in Q9CEW9_LACLA.Residues 138-212 are 33% similar to a (PHOSPHATE TRANSPORT SYSTEM HOMOLOG COMPLETE PROTEOME) protein domain (PD005667) which is seen in PHU1_THEMA.Residues 110-217 are 49% similar to a (PROTEOME SYSTEM COMPLETE REGULATOR) protein domain (PD395068) which is seen in Q9CEW9_LACLA.Residues 8-126 are 26% similar to a (TRANSPORT PHOSPHATE SYSTEM PHOU) protein domain (PD397436) which is seen in PHU2_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 11:22:18 2006","Mon Feb 11 11:48:16 2002","Wed Aug 30 11:22:18 2006","Mon Feb 11 11:43:03 2002","","Mon Feb 11 11:43:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1035 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 11 11:48:16 2002","","No significant hits to the NCBI PDB database.","SMU.1133c","","Residues 17 to 105 (E-value = 3.1e-29) place SMu1035 in the PhoU family which is described as PhoU family (PF01895)Residues 121 to 206 (E-value = 1.1e-15) place SMu1035 in the PhoU family which is described as PhoU family (PF01895)","Wed Aug 30 11:22:18 2006","","","","","","","1","","","SMU.1133c","558" "SMu1036","1076361","1075603","759","ATGACAGAACCTATTTTAAAAGTAAACGATCTTTCTGTTTACTATGGTAAAAAGAAGGCCCTTCATAGTGTATCTATTGATTTTTATCCTAATGAAATCACTTCGTTAATTGGGCCATCAGGATCTGGTAAGTCAACTTTGTTACGTGCTATCAATAGAATGGGTGATCTAAATCCCGAGGTGACAGTTACAGGTTCGATTATATATAATGGTCACAATATCTACAGCCGTCGAACAGATACAGTTGAATTACGTAAGGAAATTGGTATGGTTTTCCAGCAGCCTAACCCTTTTCCAATGACTATTTATGAAAATGTTGTTTACGGTCTTCGTTTAAAAGGTGTTAAAGATAAGAAAATTTTGGATGAAGCTGTTGAAAAATCTTTGGTAGGTGCTTCCATTTGGGATGAGGTTAAAGACCGTCTACATGATTCAGCAATTGGTTTATCAGGAGGACAGCAGCAACGTGTTTGTATTGCTAGAGTGTTAGCAACAAGCCCTAAGATTATTTTGTTAGATGAACCAACTTCAGCCTTAGATCCTATTTCAGCAGGAAAAATTGAGGATACACTTTATGGTTTGAAAGAAAAATATACAATGCTTGTGGTGACACGTTCAATGCAGCAAGCTTCACGTATTTCTAATCGTACGGGATTTTTCTTAGCTGGTGATTTGGTAGAATATGGAAATACCAAAGAAATGTTTATGAATCCGCAAAAGCAAGAAACCGAAGACTATATTACAGGTAAGTTTGGATAG","8.40","1.68","28046","MTEPILKVNDLSVYYGKKKALHSVSIDFYPNEITSLIGPSGSGKSTLLRAINRMGDLNPEVTVTGSIIYNGHNIYSRRTDTVELRKEIGMVFQQPNPFPMTIYENVVYGLRLKGVKDKKILDEAVEKSLVGASIWDEVKDRLHDSAIGLSGGQQQRVCIARVLATSPKIILLDEPTSALDPISAGKIEDTLYGLKEKYTMLVVTRSMQQASRISNRTGFFLAGDLVEYGNTKEMFMNPQKQETEDYITGKFG","1075617","For other components see SMu1037 (NBD1); SMu1038 (MSD1); SMu1039 (MSD2) and SMu1040 (SBP1).For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762 (atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE). For other 'pst' genes see SMu1002 (pstC) ; SMu1037 (pstB);SMu1038 (pstC); SMu1039 (pstC) and SMu1040 (pstS).","phosphate ABC transporter, ATP-binding protein","Membrane, Cytoplasm","Matches in gapped BLAST to phosphate ABC transporter, ATP-binding protein:residues 1-247 are 35% similar to the previously published AtmD in S.mutans (gi15625431). Residues 1-252 are 83% similar to phosphate ABC transporter, ATP-binding protein in S.pneumoniae (gi15901250).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0988 (1e-126).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[149-191]T$	ABC_transporter
PF00005	$\"[31-223]T$	ABC_tran
PS00211	$\"[149-163]T$	ABC_TRANSPORTER_1
PS50893	$\"[6-247]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-223]T$	AAA

InterPro
IPR005670
Family

Phosphate transport system permease protein 1
PTHR19222:SF24	$\"[6-250]T$	Phosp_transpt1
TIGR00972	$\"[5-252]T$	3a0107s01c2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-247]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-250]T$	PTHR19222
SSF52540	$\"[4-239]T$	SSF52540

","BeTs to 11 clades of COG1117COG name: ABC-type phosphate transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1117 is amt--qvCeBRh--gpo----Number of proteins in this genome belonging to this COG is 2","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.2e-30. IPB001140A 20-66 IPB001140B 146-184","Residues 194-250 are 64% similar to a (ATP-BINDING TRANSPORT PHOSPHATE PROTEOME) protein domain (PD006546) which is seen in Q9CEW8_LACLA.Residues 199-248 are 56% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD255463) which is seen in Q9X4T3_STRPN.Residues 149-198 are 48% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459) which is seen in MDR1_LEIEN.Residues 88-118 are 74% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496) which is seen in O67154_AQUAE.Residues 21-74 are 66% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CEW8_LACLA.Residues 149-191 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CEW8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 11:07:01 2006","Mon Feb 11 13:23:41 2002","Tue Sep 12 11:07:01 2006","Mon Feb 11 13:21:41 2002","Mon Feb 11 13:21:41 2002","Mon Feb 11 13:21:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1036 is paralogously related (blast p-value < 1e-3) to SMu1037, SMu0517, SMu0731, SMu0218, SMu1380, SMu1762, SMu0418, SMu1920, SMu0971, SMu0849, SMu1003, SMu0594, SMu0234, SMu1517, SMu0235, SMu1950, SMu1288, SMu1079, SMu1949, SMu1210, SMu0884, SMu0335, SMu1757, SMu1068, SMu1724, SMu1710, SMu0258, SMu0944, SMu0216, SMu0916, SMu1649, SMu1518, SMu0390, SMu0805, SMu0164, SMu0475, SMu1001, SMu0825, SMu1428, SMu1065, SMu0986, SMu1811, SMu1246, SMu1231, SMu0476, SMu1064, SMu0836, SMu0824, SMu1751, SMu0950, SMu0596, SMu1410, SMu0224, SMu1316, SMu0837, SMu0907, SMu0786, SMu0987, SMu0374, SMu1023, SMu1050, SMu1093, SMu1959, SMu1306, SMu0024, SMu0976, SMu0823, SMu0666, SMu0729, SMu1545, and SMu0752, all with ATP binding capabilities.","Mon Feb 11 13:24:59 2002","Tue Sep 12 11:07:01 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 128 8e-031pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 85 1e-017","SMU.1134c","","Residues 31 to 223 (E-value = 1.6e-54) place SMu1036 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Feb 11 13:21:41 2002","24379565","","Russell RR, Aduse-Opoku J, Sutcliffe IC, Tao L, Ferretti JJA binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism.J Biol Chem 1992 Mar 5;267(7):4631-7 PubMed: 1537846PMID: 1537846Novak,J., Caufield,P.W. and Miller,E.J.Isolation and biochemical characterization of a novel lantibioticmutacin from Streptococcus mutansJ. Bacteriol. 176 (14), 4316-4320 (1994)PubMed: 8021218Qi,F., Chen,P. and Caufield,P.W.Functional analyses of the promoters in the lantibiotic mutacin IIbiosynthetic locus in Streptococcus mutansAppl. Environ. Microbiol. 65 (2), 652-658 (1999)PubMed: 9925596Russell,R.R.B. and Ferretti,J.J.Nucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutansJ. Gen. Microbiol. 136, 803-810 (1990)PubMed: 2380687Ferretti,J.J., Huang,T.-T. and Russell,R.R.B.Sequence analysis of the glucosyltransferase A (gtfA) gene fromStreptococcus mutans IngbrittInfect. Immun. 56, 1585-1588 (1988)PubMed: 2967248Aduse-Opuko,J., Tao,L., Ferretti,J.J. and Russell,R.R.B.Biochemical and genetic analysis of Streptococcus mutansalpha-galactosidaseJ. Gen. Microbiol. 137, 757-764 (1991)PubMed: 1649890","","Tue Apr 2 17:41:07 2002","","1","","","SMU.1134c","350" "SMu1037","1077176","1076373","804","ATGACTGAATATAATTGGAATGAAAGACATATCATTACTTTTCCTGAAGAAATCTTGGCTTTGTCAACGAAAGATCTTCATGTTTATTACGGCGAAAAAGAAGCCATCAAAGGAATTGATATGCAATTTAAAAAAAAGAAGATCACTGCTTTAATTGGCCCTTCTGGCTGTGGGAAATCTACTTTTCTTCGTAGTTTAAATCGCATGAATGACACTATTGATATCGCTAAAGTGACTGGTCAAATCTTATTTGAAGGTATTGATGTCAATGCCGCTAATATTAATGTTTATGAAATGCGCAAACACATTGGCATGGTCTTTCAAAGACCAAATCCATTTGCGAAATCCATCTATAAAAATATTACTTTTGCTTATGAACGCGCTGGTGTTAAAGATAAACAATTTCTTGATGACATTGTCGAAACCTCTTTAAAACAAGCAGCTCTTTGGGAACAGGTGAAAGATGATCTTCATAAATCAGCTTTTACACTATCAGGTGGACAGCAACAACGGCTCTGTATTGCGCGTGCCATTGCTGTTAAGCCAGATATCCTTTTGATGGATGAACCGGCTTCTGCTTTGGATCCAATTGCAACTATGCAGCTAGAAGAAACTATGTCTGAACTTAAAGAAAACTATACTATTATTATCGTTACGCATAATATGCAGCAGGCAGCCCGGGCTAGTGATTATACCGCCTTCTTCTATTTAGGAGATTTGATTGAGTATGATAAGACAAATAATATTTTTCAAAATGCTAAATTGCAATCGACAAGTGACTATGTATCTGGACACTTTGGATAG","6.30","-2.64","30282","MTEYNWNERHIITFPEEILALSTKDLHVYYGEKEAIKGIDMQFKKKKITALIGPSGCGKSTFLRSLNRMNDTIDIAKVTGQILFEGIDVNAANINVYEMRKHIGMVFQRPNPFAKSIYKNITFAYERAGVKDKQFLDDIVETSLKQAALWEQVKDDLHKSAFTLSGGQQQRLCIARAIAVKPDILLMDEPASALDPIATMQLEETMSELKENYTIIIVTHNMQQAARASDYTAFFYLGDLIEYDKTNNIFQNAKLQSTSDYVSGHFG","1076387","For other components see SMu1036 (NBD2); SMu1038 (MSD1); SMu1039 (MSD2) and SMu1040 (SBP1).For other 'pst' genes see SMu1002 (pstC) ; SMu1038 (pstC);SMu1039 (pstC); SMu1040 (pstS) and SMu1036 (pstB).","phosphate ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to phosphate ABC transporter, ATP-bindingprotein:residues 34-262 are 32% similar to the previously published AtmD in S.mutans (gi15625431). Residues 1-267 are 89% similar to phosphate ABC transporter, ATP-binding protein in S.pyogenes (gi15675202) and are 86% similar to the protein from S.pneumoniae (gi15901251).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0989 (1e-142).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[163-206]T$	ABC_transporter
PF00005	$\"[46-238]T$	ABC_tran
PS00211	$\"[164-178]T$	ABC_TRANSPORTER_1
PS50893	$\"[21-262]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[45-239]T$	AAA

InterPro
IPR005670
Family

Phosphate transport system permease protein 1
PTHR19222:SF24	$\"[21-265]T$	Phosp_transpt1
TIGR00972	$\"[20-267]T$	3a0107s01c2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[15-262]T$	G3DSA:3.40.50.300
PTHR19222	$\"[21-265]T$	PTHR19222
SSF52540	$\"[21-254]T$	SSF52540

","BeTs to 11 clades of COG1117COG name: ABC-type phosphate transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1117 is amt--qvCeBRh--gpo----Number of proteins in this genome belonging to this COG is 2","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.5e-30. IPB001140A 35-81 IPB001140B 161-199 IPB001140C 215-244","Residues 208-242 are 60% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9UZU7_PYRAB.Residues 21-89 are 37% similar to a (NUCLEOTIDE BINDING ATP-BINDING SUBUNIT) protein domain (PD047081) which is seen in O68469_MYCSM.Residues 208-264 are 80% similar to a (ATP-BINDING TRANSPORT PHOSPHATE PROTEOME) protein domain (PD006546) which is seen in Q9CEW7_LACLA.Residues 208-261 are 60% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD255463) which is seen in Q9HML8_HALN1.Residues 155-252 are 29% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 36-90 are 67% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CEW7_LACLA.Residues 165-206 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CEW7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 11:06:34 2006","Mon Feb 11 13:32:49 2002","Tue Sep 12 11:06:34 2006","Mon Feb 11 13:32:49 2002","Mon Feb 11 13:32:49 2002","Mon Feb 11 13:32:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1037 is paralogously related (blast p-value < 1e-3) to SMu1036, SMu0517, SMu0731, SMu1380, SMu0218, SMu0849, SMu0418, SMu1920, SMu1003, SMu1762, SMu1949, SMu0971, SMu0234, SMu1950, SMu1288, SMu1210, SMu0824, SMu0335, SMu1246, SMu1231, SMu1079, SMu0805, SMu1068, SMu1757, SMu0884, SMu0596, SMu0235, SMu1001, SMu0825, SMu0786, SMu0475, SMu1517, SMu0916, SMu0390, SMu1428, SMu1518, SMu0986, SMu1065, SMu0907, SMu1064, SMu0594, SMu0476, SMu1751, SMu1710, SMu0164, SMu0836, SMu0944, SMu1410, SMu0258, SMu0216, SMu0224, SMu1959, SMu1811, SMu1649, SMu1724, SMu0837, SMu0950, SMu1023, SMu1093, SMu0987, SMu1316, SMu0976, SMu1306, SMu1050, SMu0374, SMu1545, SMu0729, SMu0024, SMu0752, SMu0823, SMu0666, SMu1202, SMu1433, and SMu1686, all with ATP binding capabilities.","Mon Feb 11 13:33:16 2002","Tue Sep 12 11:06:34 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 114 1e-026pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 85 7e-018","SMU.1135c","","Residues 46 to 238 (E-value = 3.5e-55) place SMu1037 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Feb 11 13:32:49 2002","","","","","","","1","","","SMU.1135c","351" "SMu1038","1078079","1077192","888","ATGAACGCTAAGAAACTTGATAAGTTAGCTACAGGTATTCTCTACACGATTGCGGGTATTATTGTTGCCATCTTGGCTTCGCTCTTGCTCTTTATTCTTGTACGAGGTTTACCTAATGTCAGTTGGCACTTTTTGACAGGCCGTTCCTCTTCTTATGAAGCTGGTGGCGGTATTGGTATTCAGCTTTACAATTCTTTCTTTCTTTTGGTCGTGACATTAATTATTTCCATACCTTTGTCTATGGGAGCAGGGATTTATTTATCTGAATATGCTAAAAAGGGACGTTTGACTGACTTTGTACGTACTTGTATTGAAATTCTATCGTCCCTTCCATCGGTTGTTGTTGGACTTTTTGGCTATTTGATTTTTGTTGTTCAATTTCAATATGGTTTTTCTATTATTTCAGGAGCTTTGGCCTTAACCGTCTTTAATCTGCCACAAATGACACGTAATATTGAAGATAGTTTACGCAATGTGCACCATACTCAGCGCGAGGCTGGTCTTGCTTTAGGTATTTCTCGTTGGGAAACTGTTTTACATGTTGTCATTCCCGAAGCACTTCCGGGGATTGTGACAGGAATTGTCTTGGCTTCTGGTCGGATTTTTGGTGAAGCAGCGGCACTTATTTATACGGCAGGTCAATCGGCACCTGCTCTTGATTGGGGTAATTGGAATCCACTTAGTGTTACCAGTCCGATTTCTATTTTTCGTCAATCTGAAACTCTTGCTGTTCATATTTGGAAAGTTAATAGTGAAGGCACTATTCCAGATGCGACCAAAGTATCAGAAGGAAGCGCAGCAGTCTTGCTTATCTTTATTTTGATTTTCAATCTGTCTGCTCGTTATATTGGTAAAAAATTACATGCTAAGTTGACATCAGCAGCTTAA","10.10","6.39","31759","MNAKKLDKLATGILYTIAGIIVAILASLLLFILVRGLPNVSWHFLTGRSSSYEAGGGIGIQLYNSFFLLVVTLIISIPLSMGAGIYLSEYAKKGRLTDFVRTCIEILSSLPSVVVGLFGYLIFVVQFQYGFSIISGALALTVFNLPQMTRNIEDSLRNVHHTQREAGLALGISRWETVLHVVIPEALPGIVTGIVLASGRIFGEAAALIYTAGQSAPALDWGNWNPLSVTSPISIFRQSETLAVHIWKVNSEGTIPDATKVSEGSAAVLLIFILIFNLSARYIGKKLHAKLTSAA","1077206","For other components see SMu1037 (NBD1); SMu1036 (NBD2); SMu1039 (MSD2) and SMu1040 (SBP1).For other 'pst' genes see SMu1002 (pstC) ; SMu1037 (pstB);SMu1039 (pstC); SMu1040 (pstS) and SMu1036 (pstB).","phosphate ABC transporter, permease","Membrane, Cytoplasm","Matches in gapped BLAST to phosphate ABC transporter:residues 1-294 are 88% similar to the protein in S.pyogenes (gi15675203)and are 86% similar to the protein in S.pneumoniae (gi15903298).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0990 (1e-149).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[62-293]T$	BPD_transp_1
PS50928	$\"[62-280]T$	ABC_TM1

InterPro
IPR005672
Family

Phosphate transport system permease protein 2
TIGR00974	$\"[7-289]T$	3a0107s02c

","BeTs to 10 clades of COG0581COG name: Phosphate permease component of ATP-dependent phosphate uptake systemFunctional Class: PThe phylogenetic pattern of COG0581 is amt--qvCEbRh----o----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 62-142 are 40% similar to a (PHOSPHATE PERMEASE PROTEOME COMPLETE) protein domain (PD409002) which is seen in Q9KN93_VIBCH.Residues 60-128 are 37% similar to a (TRANSPORT PHOSPHATE PERMEASE COMPLETE) protein domain (PD411162) which is seen in Q9CNJ5_PASMU.Residues 146-210 are 43% similar to a (TRANSPORT PERMEASE COMPLETE TRANSMEMBRANE) protein domain (PD001159) which is seen in Q9PBK1_XYLFA.Residues 145-215 are 67% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in Q9CEW6_LACLA.Residues 1-58 are 48% similar to a (ABC TRANSPORT TRANSPORTER PERMEASE) protein domain (PD266715) which is seen in YQGI_BACSU.Residues 219-294 are 59% similar to a (PERMEASE TRANSPORTER ABC PROTEOME) protein domain (PD059917) which is seen in Q9CEW6_LACLA.Residues 1-61 are 50% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD385808) which is seen in Q9CEW6_LACLA.Residues 62-142 are 73% similar to a (TRANSPORT PHOSPHATE PERMEASE COMPLETE) protein domain (PD002010) which is seen in Q9CEW6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 11:03:46 2006","Tue Sep 12 11:03:46 2006","Tue Sep 12 11:03:46 2006","Mon Feb 11 13:40:31 2002","","Mon Feb 11 13:40:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1038 is paralogously related (blast p-value < 1e-3) to SMu1039, SMu0970, SMu1002, SMu1921, SMu1383, SMu0595, SMu0847, SMu1923, and SMu1382, all predicted ABC transporter, permease protein.","Mon Feb 11 13:50:46 2002","","No significant hits to the NCBI PDB database.","SMU.1136c","","Residues 62 to 293 (E-value = 9.6e-34) place SMu1038 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Mon Feb 11 13:40:31 2002","","","","","","","1","","","SMU.1136c","352" "SMu1039","1079004","1078069","936","ATGAAAAATCAAGAACTTGCTAAAAAGCTGACATCTCCTTCCAAAAATTCTCGTTTGGAAAAATTCGGAAAGATGATTACGCTTTTCTGCTTAATCTTAATTGTTATTATTGTAGCAATGATTCTTATTTTTGTTGCCCAAAAGGGATTGTCAACCTTTTTTGTGAATAAAATCAATCCTCTTAAATTTTTGTTTGGGACAGAGTGGCAGCCAAATGTTAAAGGAGCTGATGGTAAACCATTACTTGGGGCTTTACCGATGATCTTAGGTTCCTTTATTGTAACTATTTTATCTGCTATTATTGCGACTCCTTTTGCTATTGGAGCAGCAGTCTTTATGACTGAAATTTCACCTAAGTACGGTGCCAAAATTTTACAGCCTGTCGTTGAGCTTTTGGTAGGAATTCCTTCAGTTGTTTATGGTTTTATTGGTTTGCAAATTGTGGTTCCTTTTGTGAGATCTATTTTTGGCGGTACTGGTTTTGGGATTTTATCAGGGGTTTTTGTTCTCTTTGTTATGATTTTACCAACAGTAACTTTTATGACAGTTGATAGTTTGAAGGCCGTTCCGAGGCATTATAAGGAAGCCAGTCTTGCTATGGGAGCTACTCGCTGGCAAACGATTTGGCGTGTGATTTTAAATGCTGCTAAGCCAGGTATTTTTACGGCCGTTGTTTTTGGGATGGCTCGAGCTTTTGGTGAAGCCTTAGCTATCCAAATGGTAGTTGGTAATTCAGCTGTTATTCCGACGTCATTGACCACACCTGCAGCAACTTTGACATCAGTCTTAACAATGGGAATCGGTAATACGGTTATGGGAACCGTTCAAAATAATGTCCTTTGGTCCTTAGCCTTAGTTCTTCTCATTATGAGTCTGGCCTTTAATATGCTGATGAGATTTATTACAAGGGAAGGTAAGAAAAATTATGAACGCTAA","11.00","16.18","33654","MKNQELAKKLTSPSKNSRLEKFGKMITLFCLILIVIIVAMILIFVAQKGLSTFFVNKINPLKFLFGTEWQPNVKGADGKPLLGALPMILGSFIVTILSAIIATPFAIGAAVFMTEISPKYGAKILQPVVELLVGIPSVVYGFIGLQIVVPFVRSIFGGTGFGILSGVFVLFVMILPTVTFMTVDSLKAVPRHYKEASLAMGATRWQTIWRVILNAAKPGIFTAVVFGMARAFGEALAIQMVVGNSAVIPTSLTTPAATLTSVLTMGIGNTVMGTVQNNVLWSLALVLLIMSLAFNMLMRFITREGKKNYER","1078083","For other components see SMu1037 (NBD1); SMu1036 (NBD2); SMu1038 (MSD1) and SMu1040 (SBP1).For other 'pst' genes see SMu1002 (pstC) ; SMu1037 (pstB);SMu1038 (pstC); SMu1040 (pstS) and SMu1036 (pstB).","phosphate ABC transporter, permease","Membrane, Cytoplasm","Matches in gapped BLAST to phosphate ABC transporter, ATP-bindingprotein:residues 76-233 are 24% similar to the previously published membrane protein in S.mutans (gi153738). Residues 1-311 are 77% similar to phosphate ABC transporter, ATP-binding protein in S.pyogenes (gi15675204) and are 72% similar to the protein in S.pneumoniae (gi15901253) .The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0991 (1e-132).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[88-307]T$	BPD_transp_1
PS50928	$\"[88-298]T$	ABC_TM1

InterPro
IPR011864
Family

Phosphate ABC transporter, permease protein PstC
TIGR02138	$\"[20-306]T$	phosphate_pstC

","BeTs to 11 clades of COG0573COG name: Phosphate permeaseFunctional Class: PThe phylogenetic pattern of COG0573 is amt--qvCebRh--gpo----Number of proteins in this genome belonging to this COG is 1","***** IPB000515 (Binding-protein-dependent transport systems inner membrane component) with a combined E-value of 1.6e-07. IPB000515 195-214","Residues 90-182 are 80% similar to a (PHOSPHATE PERMEASE PROTEOME COMPLETE) protein domain (PD409002) which is seen in Q9CEW5_LACLA.Residues 88-153 are 45% similar to a (TRANSPORT PHOSPHATE PERMEASE COMPLETE) protein domain (PD411162) which is seen in Q9KN94_VIBCH.Residues 176-242 are 41% similar to a (TRANSPORT PERMEASE COMPLETE TRANSMEMBRANE) protein domain (PD001159) which is seen in Q9HML6_HALN1.Residues 188-299 are 50% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in YQGH_BACSU.Residues 123-229 are 29% similar to a (PROTEOME COMPLETE MEMBRANE NITRATE) protein domain (PD298221) which is seen in Q9PG91_XYLFA.Residues 2-86 are 49% similar to a (PERMEASE TRANSPORTER ABC PROTEOME) protein domain (PD090708) which is seen in Q9CEW5_LACLA.Residues 262-305 are 59% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD386165) which is seen in Q9CEW5_LACLA.Residues 90-164 are 30% similar to a (TRANSPORT PHOSPHATE PERMEASE COMPLETE) protein domain (PD002010) which is seen in Q9HS12_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 15:05:23 2006","Thu Sep 28 15:05:23 2006","Tue Sep 12 11:27:48 2006","Mon Feb 11 13:55:21 2002","Mon Feb 11 13:55:21 2002","Mon Feb 11 13:55:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1039 is paralogously related (blast p-value < 1e-3) to SMu1038, SMu0970, SMu0886, SMu1921, SMu0885, SMu0847, and SMu0802, all predicted ABC transporters, permease protein.","Mon Feb 11 14:01:43 2002","","No significant hits to the NCBI PDB database.","SMU.1137c","","Residues 88 to 307 (E-value = 1e-22) place SMu1039 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Mon Feb 11 13:55:21 2002","","","","","Tue Apr 2 17:41:44 2002","","1","","","SMU.1137c","353" "SMu1040","1079940","1079077","864","ATGAAAAAGAAAAAAGTAACTTTATTCGCAATGCTAGCCCTGGCTAGTCTTGTCTTAGCGGCATGTTCCAATTGGATTGATAAAGGGCAGTCAATTACCAGTGTTGGTTCTACGGCTTTGCAGCCTTTAGTTGAAGCTTCTTCGGATGAATTTGGACATGCTAACATTGGCAAAACAGTTAATGTTCAAGGTGGAGGTTCTGGTACAGGACTTTCTCAAGTTCAATCAGGTGCCATTCAAATTGGAAATAGCGATCTTTTTGCTGAAGAAAAAGATGGTATTGATGCCAGTAAGTTAGTCGACCATAAAGTTGCTGTTGCAGGAATTGCTGTCATTACTAACAAAAAAGTTAAAGTATCAAATTTAACCCTTGATCAATTAAGAAAAATTTTCACGGGAGAATATACAAACTGGAAACAGCTTGGCGGGCAAGATTTGGAAATTTCGATCATCAATCGTGCTGCTAGTTCGGGTTCACGTGCTACCTTTGACAGTGTCGTCATGAAAGGAAAAAGTGCCAGACAAAGTCAAGAACAAGATTCAAATGGGATGGTGAAGTCAATTGTTTCACAGACACCGGGCGCTATTTCTTACCTCGCTTTTGCTTACGTTGATAAGTCAGTGAAAACTTTAAAGTTAAATGGTTATGAACCAACCGTTAAGAATGTCACAACTAATAATTGGCCGCTCTGGTCTTATGAACACATGTATACTAAAGGAAAAGCCAAAGGTTTAACCAAAGAATTTTTAAAGTTCATGATGAGTGACAAGATTCAAAAAGGTGTTGTGACCAGAATGGGTTATATTTCTGTTAATGATATGAAAGTGGTTAAGCGTGCAGATGGCACTGTAATTGCTAAGTAA","10.40","13.67","30882","MKKKKVTLFAMLALASLVLAACSNWIDKGQSITSVGSTALQPLVEASSDEFGHANIGKTVNVQGGGSGTGLSQVQSGAIQIGNSDLFAEEKDGIDASKLVDHKVAVAGIAVITNKKVKVSNLTLDQLRKIFTGEYTNWKQLGGQDLEISIINRAASSGSRATFDSVVMKGKSARQSQEQDSNGMVKSIVSQTPGAISYLAFAYVDKSVKTLKLNGYEPTVKNVTTNNWPLWSYEHMYTKGKAKGLTKEFLKFMMSDKIQKGVVTRMGYISVNDMKVVKRADGTVIAK","1079091","For other components see SMu1037 (NBD1); SMu1036 (NBD2); SMu1038 (MSD1) and SMu1039 (MSD2).For other 'pst' genes see SMu1002 (pstC) ; SMu1037 (pstB);SMu1038 (pstC); SMu1039 (pstC) and SMu1036 (pstB).","phosphate ABC transporter, periplasmic phosphate-binding protein","Membrane, Extracellular","Matches in gapped BLAST to phosphate ABC transporter, periplasmic phosphate-binding protein:residues 3-284 are 74% similar to the protein in S.pyogenes (gi|15675205|).Residues 2-284 are 65% similar to the protein in S.pneumoniae (gi|15675204|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0992 (1e-119).","

InterPro
IPR006059
Family

Bacterial extracellular solute-binding protein, family 1
PF01547	$\"[7-85]T$	SBP_bac_1

InterPro
IPR011862
Family

Phosphate binding protein
TIGR02136	$\"[1-271]T$	ptsS_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[108-232]T$	G3DSA:3.40.190.10
PS51257	$\"[1-22]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[17-287]T$	SSF53850

","BeTs to 10 clades of COG0226COG name: Periplasmic phosphate-binding proteinFunctional Class: PThe phylogenetic pattern of COG0226 is amT--qvCebRh--gpo----Number of proteins in this genome belonging to this COG is 1","***** IPB002370 (Phosphate-binding protein) with a combined E-value of 6.7e-19. IPB002370A 66-85 IPB002370B 120-143 IPB002370C 151-167","Residues 32-269 are 51% similar to a (COMPLETE PROTEOME PHOSPHATE BINDING) protein domain (PD002295) which is seen in YQGG_BACSU.Residues 31-163 are 27% similar to a (TRANSPORT PRECURSOR PHOSPHATE-BINDING) protein domain (PD120947) which is seen in Q49590_MYCIT.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:46:38 2002","Tue Feb 12 09:02:43 2002","Wed Oct 16 08:07:53 2002","Tue Feb 12 09:02:43 2002","Tue Feb 12 09:02:43 2002","Tue Feb 12 09:02:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1040 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 09:03:21 2002","","No significant hits to the NCBI PDB database.","SMU.1138c","","Residues 7 to 260 (E-value = 2.9e-07) place SMu1040 in the SBP_bac_1 family which is described as Bacterial extracellular solute-binding protein (PF01547)","Tue Feb 12 09:02:43 2002","","","","","","","1","","","SMU.1138c","354" "SMu1041","1081347","1080037","1311","ATGTTATTACCTGATAAATTTGTAGAAAAATATCAAACCATTTTAGGCTCTAAAGCTAAAACTTTTTTAAAGAGTTTTGATCAAGAACCCATTTGGGCTTTTCGGACAAATCCTTTAAAGAAAGAGCAGCTTCTTTTTGAAGATGCTATTCCCAATACCGTTTGGGGTCACTATGGCAAAGTTTTTGGGAAATCAGCAGAGCATGTTTCTGGTTTGGTTTATTCCCAAGAGCCTGCAGCTCAGATGGTTGTTCAAGCAGCAGCTCCTCAAAAAGGAATGAAGGTGCTTGATTTAGCAGCAGCACCGGGAGGCAAAACGACTCATCTTTTATCCTATCTTGATAATAGTGGTATTTTAGTCAGTAATGATATTTCAAAAAAGCGCAGTAAAATTCTTGTTGAAAATGTTGAACGTTTTGGTGCTCGAAATGTTGTTGTTACCAATGAAAGTCCTCAAAACTTAGCCAAGGTTTTTGGGAATTATTTTGATTTAATTGTTTTAGATGCTCCTTGTTCAGGTGAAGGCATGTTTCGGAAAGATCCAGCAGCTATTCAGTACTGGCATGAAGCATATCCAGTGGAATGTGCAGAGCTTCAAAAAAAAATCTTAGCAGAAGCCATGAAAATGTTAGCAGCTGGCGGCAACTTAGTTTATTCTACTTGTACTTGGGCGCCTGAAGAAAATGAAGCGGTTATCAGGTGGCTGCTTTCTCAATACGATTATTTAGAATTGGTGAATGTTCCTAAGTTAAATGGTATGGTTCAAGGCATTGATATGCCACAAGTGGCTCGTATGTATCCCCATCTTTTCAAGGGGGAAGGACAGTTTATTGCTAAATTACGCGATAGACGGTCGTCTAGAACAGTTCCTGTCAAGTCTGCTAGAAATCGGTTAAAAAGGGAACAAGAGCAGTTGTGGCAGGATTTTGCTCATAAACATCTTAACGTTAAATTAGATGGTTTTTATCAAACTTTTGGTGATAAACTTTATCTCTTGCCACATGGTTTACCCGATATGTCTCAATTAAAAATCGCTCGAAATGGTTTGCATTTGGGGACTTTTAAGAAAAATCGTTTCGAACCCTCCTTTGCTTTAGGACTTGCCTTAAGAAAGGATGAAGTTGTTCAATCAATAGAAATTGATATAGAACAGTTTAAAGTATATACCTCTGGAAATATTATTGCCCTTACTACAAATTATGAAAATGGATGGTATCAAATTCTTATAAATGGTAATGGTCTAGGTTTTGCAAAAGTAGTTGGAAATACTATTAAAAATTATTTTCCTAAAGGCCTTCGTTTTTTATCCTGA","9.90","12.05","49189","MLLPDKFVEKYQTILGSKAKTFLKSFDQEPIWAFRTNPLKKEQLLFEDAIPNTVWGHYGKVFGKSAEHVSGLVYSQEPAAQMVVQAAAPQKGMKVLDLAAAPGGKTTHLLSYLDNSGILVSNDISKKRSKILVENVERFGARNVVVTNESPQNLAKVFGNYFDLIVLDAPCSGEGMFRKDPAAIQYWHEAYPVECAELQKKILAEAMKMLAAGGNLVYSTCTWAPEENEAVIRWLLSQYDYLELVNVPKLNGMVQGIDMPQVARMYPHLFKGEGQFIAKLRDRRSSRTVPVKSARNRLKREQEQLWQDFAHKHLNVKLDGFYQTFGDKLYLLPHGLPDMSQLKIARNGLHLGTFKKNRFEPSFALGLALRKDEVVQSIEIDIEQFKVYTSGNIIALTTNYENGWYQILINGNGLGFAKVVGNTIKNYFPKGLRFLS","1080051","","rRNA methyltransferase, NOL1/NOP2/sun family","Cytoplasm, Extracellular","Matches in gapped BLAST to nucleolar protein and to NOL1/NOP2/sun family protein: residues 1-434 are 64% similar to the protein in S.pyogenes (gi15675206) and are 62% similar to NOL1/NOP2/sun family protein from S.pneumoniae (gi15901256). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0993 (0.0).","

InterPro
IPR001678
Domain

Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p
PF01189	$\"[71-281]T$	Nol1_Nop2_Fmu

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[76-283]T$	G3DSA:3.40.50.150
PTHR22807	$\"[62-281]T$	PTHR22807
PTHR22807:SF12	$\"[62-281]T$	PTHR22807:SF12
SSF53335	$\"[3-282]T$	SSF53335

","BeTs to 10 clades of COG0144COG name: Predicted rRNA methylaseFunctional Class: JThe phylogenetic pattern of COG0144 is Am-KY-vcEbrh------in-Number of proteins in this genome belonging to this COG is 2","***** IPB001678 (NOL1/NOP2/sun family) with a combined E-value of 8.9e-44. IPB001678B 95-109 IPB001678C 117-140 IPB001678D 162-179 IPB001678E 211-237 IPB001678F 266-282","Residues 265-432 are 24% similar to a (PROTEOME SUN/NUCLEOLAR PRC-PRPA COMPLETE) protein domain (PD115221) which is seen in Q9KRY1_VIBCH.Residues 198-281 are 39% similar to a (COMPLETE PROTEOME CG5558 NUCLEOLAR) protein domain (PD115214) which is seen in Q9V0L5_PYRAB.Residues 63-175 are 40% similar to a (PROTEOME COMPLETE NUCLEOLAR FMU) protein domain (PD003196) which is seen in Q9KRY1_VIBCH.Residues 198-280 are 39% similar to a (PROTEOME COMPLETE LONG ANTIGEN) protein domain (PD244371) which is seen in Q9HRX7_HALN1.Residues 176-281 are 35% similar to a (NUCLEOLAR P120 PROTEOME ANTIGEN) protein domain (PD300819) which is seen in O29405_ARCFU.Residues 178-234 are 47% similar to a (PROTEOME COMPLETE FMU NUCLEOLAR) protein domain (PD319848) which is seen in YEBU_ECOLI.Residues 199-252 are 47% similar to a (CG11109 F12K11.10) protein domain (PD268792) which is seen in Q9SHK0_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 12 09:13:21 2002","Tue Sep 12 11:55:20 2006","Tue Sep 12 11:55:20 2006","Tue Feb 12 09:10:46 2002","Tue Feb 12 09:10:46 2002","Tue Feb 12 09:10:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1041 is paralogously related (blast p-value < 1e-3) to SMu0436, a predicted RNA-binding Sun protein; possible rRNA methylase.","Tue Feb 12 09:19:21 2002","","No significant hits to the NCBI PDB database.","SMU.1139c","","Residues 22 to 281 (E-value = 5.4e-33) place SMu1041 in the Nol1_Nop2_Sun family which is described as NOL1/NOP2/sun family (PF01189)","Tue Feb 12 09:10:46 2002","24379570","","","","","","1","","","SMU.1139c","355" "SMu1042","1082103","1081411","693","ATGACAAAGGATCTTACCATTGAAGAAAAGTCGACTTTTGATGATCTGGTGACCGATTTAGATAAGGCTGTTCAATCGTTAATGGTTAAACGTATCAATAGTACTTATCCTCAGGATCATGTTTTTGCAGAAGAAAATGATCTTGTAGCGGATATTAATAATGGTGCTGTCTGGGTTTTGGATCCTATTGATGGAACCATTAATTTTGTTGTACAGGGCTGTGATTTTGCGGTTATGATTGCTTATTATGAAAATGGAATAGGACAATTTGGACTCATTTATGATGTCATGAATGATCTTCTTTACAATGGTGGCGGTCAGTTTGAGGTTAAGGTTAACGACAAAGTTTTAAAACCTTTTCAAGATAGACCCTTTAATCGTTCTTTGATTGGTGCTAATAATGGTATGTGTGCACAAAATGTTATGGGGATTGCCGATTTCGGTCGTCAAACCTTAGGTATTCGCGGAATTGGCAGTGCAGGTCTCAGTATCTGCCGAGTCTTAGAGGGACGTCTCATGGCTTATTTTTCTAATATTTCACCTTGGGACTATGCTGCTGGTAGTGTTATGGGAGAAAAATTAGGCTATGTTGCTCTTGACTTGTACGGGCAAAAGCCTAATTACAAAACAAGACAAAAAATCATGTTTATTCCTAAAATGAAGTTGAAAGAAATTCAAAGGTACATCAAGTAA","5.10","-2.90","25725","MTKDLTIEEKSTFDDLVTDLDKAVQSLMVKRINSTYPQDHVFAEENDLVADINNGAVWVLDPIDGTINFVVQGCDFAVMIAYYENGIGQFGLIYDVMNDLLYNGGGQFEVKVNDKVLKPFQDRPFNRSLIGANNGMCAQNVMGIADFGRQTLGIRGIGSAGLSICRVLEGRLMAYFSNISPWDYAAGSVMGEKLGYVALDLYGQKPNYKTRQKIMFIPKMKLKEIQRYIK","1081425","","conserved hypothetical protein (possible myo-inositol-1(or 4)-monophosphatase)","Cytoplasm","Matches in gapped BLAST to myo-inositol-1(or 4)-monophosphatase and to conserved hypothetical protein: residues 1-229 are 55% similar to gi15675207 from S.pyogenes and are 51% similar to gi15903303 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0994 (2e-76).","

InterPro
IPR000760
Family

Inositol monophosphatase
PD023420	$\"[17-70]T$	Inositol_P
PR00378	$\"[33-49]T$ $\"[53-72]T$ $\"[178-196]T$	INOSPHPHTASE
PTHR20854	$\"[37-190]T$	Inositol_P
PF00459	$\"[3-108]T$ $\"[153-189]T$	Inositol_P

noIPR
unintegrated

unintegrated
G3DSA:3.30.540.10	$\"[1-117]T$	G3DSA:3.30.540.10
G3DSA:3.40.190.80	$\"[140-229]T$	G3DSA:3.40.190.80
PTHR20854:SF4	$\"[37-190]T$	PTHR20854:SF4
SSF56655	$\"[3-230]T$	SSF56655

","BeTs to 11 clades of COG0483COG name: Inositol phosphatase family proteinsFunctional Class: GThe phylogenetic pattern of COG0483 is aMtkYqvCebRh----o---XNumber of proteins in this genome belonging to this COG is 1","***** IPB000760 (Inositol monophosphatase) with a combined E-value of 4.7e-21. IPB000760A 15-45 IPB000760B 58-69 IPB000760C 182-200","Residues 1-68 are 42% similar to a (MONOPHOSPHATASE COMPLETE PROTEOME INOSITOL EXTRAGENIC) protein domain (PD038058) which is seen in SUHB_BACSU.Residues 10-68 are 36% similar to a (MONOPHOSPHATASE INOSITOL MYO-INOSITOL-1OR LITHIUM IMP) protein domain (PD268345) which is seen in Q9VUW4_DROME.Residues 69-205 are 33% similar to a (PROTEOME COMPLETE MYO-INOSITOL-1OR) protein domain (PD237892) which is seen in Q9K9L0_BACHD.Residues 69-230 are 46% similar to a (YFDE PROTEOME COMPLETE) protein domain (PD398846) which is seen in Q9CI18_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:08:57 2002","Wed Oct 16 08:08:57 2002","Mon Jul 31 14:43:39 2006","Tue Feb 12 09:32:15 2002","Tue Feb 12 09:32:15 2002","Tue Feb 12 09:32:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1042 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 08:08:57 2002","Mon Jul 31 14:43:39 2006","pdb1IMBA Chain A, Inositol Monophosphatase (E.C.3.1.3.25) Com... 83 2e-017pdb2HHMA Chain A, Human Inositol Monophosphatase (E.C.3.1.3.2... 83 2e-017","SMU.1140c","","Residues 1 to 230 (E-value = 2.3e-17) place SMu1042 in the Inositol_P family which is described as Inositol monophosphatase family (PF00459)","Tue Feb 12 09:32:15 2002","24379571","","","","","","1","","","SMU.1140c","676" "SMu1043","1082437","1082159","279","ATGACTAAGAATTACGCTTACCCTTTGGATTTGTCGTGGAGCACTGAAGAGATAACCTCAGTGCTTTCTTTTTTAAATTTGGTAGAAAAAGCTTATGAAAACAGAGTTGAAGCTGCTCTTTTGTTAAAAAGTTATCAGAATTACAAAACGATTGTTAGCAGCAAGTTGCAAGAAAAGCAAATCGATCGTAATTTTGAAAGGGTTAGTGGTTATTCTACCTATCGAGCTGTTCAAGCCGCAAAAGCTAAAGAGAAAGGATTCATCTCTCTTGAAAACTAA","9.70","1.99","10605","MTKNYAYPLDLSWSTEEITSVLSFLNLVEKAYENRVEAALLLKSYQNYKTIVSSKLQEKQIDRNFERVSGYSTYRAVQAAKAKEKGFISLEN","1082173","","conserved hypothetical protein","Membrane, Extracellular","Matches in gapped BLAST to conserved hypothetical protein. Residues 1-92 are 70% similar to gi|15675208| from S.pyogenes. Residues 1-90 are 65% similar to gi|15901258| from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0995 (8e-29).","

InterPro
IPR007920
Family

Protein of unknown function UPF0223
PF05256	$\"[3-90]T$	UPF0223

noIPR
unintegrated

unintegrated
PD062738	$\"[4-90]T$	PD062738

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-82 are 61% similar to a (PROTEOME COMPLETE YFDD BH2638) protein domain (PD062738) which is seen in Q9CI19_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 12 09:40:27 2002","Tue Feb 12 09:40:27 2002","Tue Feb 12 09:40:27 2002","Tue Feb 12 09:40:27 2002","","Tue Feb 12 09:40:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1043 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 09:40:27 2002","","No significant hits to the NCBI PDB database.","SMU.1141c","","Residues 3 to 90 (E-value = 1.6e-51) place SMu1043 in the UPF0223 family which is described as Uncharacterised protein family (UPF0223) (PF05256)","Tue Feb 12 09:40:27 2002","24379572","","","","","","1","","","SMU.1141c","930" "SMu1044","1082843","1082430","414","ATGGTTACCTTATTTTTATCACCTAGCTGTACAAGCTGCCGTAAAGCGAGAGCTTGGCTGAATAGACATGATGTTGTTTTTCAGGAACACAATATTATGACTAGTCCCTTGAGTCGTGATGAACTATTAAAAATTTTATCCTATACAGAAAACGGGACAGAAGATATTATTTCGACACGTTCCAAGGTTTTTCAGAAATTAGACATTGATGTAGATGAATTGTCCGTCTCGGAATTAATCAATCTTATTTCCAAGAATCCAAGTTTGCTTCGCCGTCCTATTATCATGGATAATAAACGTATGCAAATTGGTTTTAATGAAGATGAGATTCGTGCCTTTTTACCACGAGACTATCGCAAACAAGAACTGCGTCAAGCAACTATCAGAGCGGAAGTTGAGGGAGAAGATGACTAA","5.40","-2.61","15952","MVTLFLSPSCTSCRKARAWLNRHDVVFQEHNIMTSPLSRDELLKILSYTENGTEDIISTRSKVFQKLDIDVDELSVSELINLISKNPSLLRRPIIMDNKRMQIGFNEDEIRAFLPRDYRKQELRQATIRAEVEGEDD","1082444","","conserved hypothetical protein (possible arsenate reductase)","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-134 are 87% similar to S.pyogenes (gi|15675209|) and residues 1-132 are 75% similar to S.pneumoniae (gi|15901259|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0996 (6e-64).","

InterPro
IPR006504
Family

Conserved hypothetical protein, ArsC related
TIGR01617	$\"[2-115]T$	arsC_related

InterPro
IPR006660
Family

Arsenate reductase and related
PF03960	$\"[5-115]T$	ArsC

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[1-115]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[1-125]T$	IPR012336

","BeTs to 3 clades of COG1393COG name: Arsenate reductase, E.coli typeFunctional Class: PThe phylogenetic pattern of COG1393 is --------EB-H--gp-----Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 2-95 are 29% similar to a (ARSENATE REDUCTASE ARSENICAL) protein domain (PD004262) which is seen in Q9K785_BACHD.Residues 97-123 are 74% similar to a (YFDC PROTEOME COMPLETE) protein domain (PD371151) which is seen in Q9CI20_LACLA.Residues 4-104 are 61% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE MG127) protein domain (PD030877) which is seen in Q9RGX0_LISMO.Residues 7-115 are 30% similar to a (PROTEOME YNEH COMPLETE) protein domain (PD396666) which is seen in Q9CFZ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 12 10:02:32 2002","Wed Oct 16 08:10:02 2002","Wed Oct 16 08:10:02 2002","Tue Feb 12 10:01:19 2002","","Tue Feb 12 10:01:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1044 is paralogously related (blast p-value < 1e-3) to SMu1891, a predicted conserved hypothetical protein (possible arsenate reductase) and SMu1503, a predicted arsenate reductase.","Tue Feb 12 10:02:32 2002","","No significant hits to the NCBI PDB database.","SMU.1142c","","Residues 5 to 115 (E-value = 1.9e-57) place SMu1044 in the ArsC family which is described as ArsC family (PF03960)","Tue Feb 12 10:01:19 2002","24379573","","","","","","1","","","SMU.1142c","801" "SMu1045","1083824","1082904","921","ATGGAAATTATAAAAATAGACAGTCATAAAGATATTGAGCAACAAGAAGATTCGGTCTTGGTTTTGGGCTATTTTGATGGGCTTCATAGAGGGCATAAGGAACTTTTTAATCAAGCTAGGGAAATAGCCCAAAAGATGCAACTGAAAATAGTTGTCTTGACCTTTCCAGAGTCTCCTCAATTAGCTTTCACGCGTTTTGAGCCCGATTTACTCAATCATATTAATTACCCAGAAAAACGCTATTGTAAGTTTGCAGAGTACGGAGTTGACTGTCTTTATTTGACAGATTTTACTTCTTCCTTTGCAAAGATCAGTTCTGATGATTTTATCAAAAACTATATTAAAGCTCTGAAAGCTAAGGCTGTTGTTATGGGGTTTGATTATAAATTCAGTCATAGTAAAGCAAATTCTGATTATCTTAAGCATCATTTTGCGGGGCAAGTCATTACCGTTCCTGAAGTACAGTATGAGGGGAAGAAGATTAGTTCAACGCGCGTGCGCCAGCTCATTAAACAAGGTGATATGACTCAAGTTAACCGTCTTTTAGGCTATGAGTTTTCAACACGAGGAATAGTGGTACACGGTGATGCCAGAGGACGTACAATTGGTTTTCCAACTGCTAATCTTGCACCGCTGGATCGGACTTATTTACCAGCCGATGGTGTTTATGTGGCTGATGTTATTGTCGGCAGGAAGCGTTATCGTTCCATGACCAGTATTGGTAAAAATATCACTTTTGGAGGAACGGAATTGCGTCTTGAAGCTAATATATTTGACTTTGACGATGATATTTACGGCGAGACAATTGAAATTTTCTGGCTAAATAAAATTCGTGAAATGGTTAAATTTAATAGCGTCAATGATTTGGTTGAACAATTAAAATCTGATAAAGAAATTGCGATAAATTGGGGAAAATCATAG","7.70","1.85","35095","MEIIKIDSHKDIEQQEDSVLVLGYFDGLHRGHKELFNQAREIAQKMQLKIVVLTFPESPQLAFTRFEPDLLNHINYPEKRYCKFAEYGVDCLYLTDFTSSFAKISSDDFIKNYIKALKAKAVVMGFDYKFSHSKANSDYLKHHFAGQVITVPEVQYEGKKISSTRVRQLIKQGDMTQVNRLLGYEFSTRGIVVHGDARGRTIGFPTANLAPLDRTYLPADGVYVADVIVGRKRYRSMTSIGKNITFGGTELRLEANIFDFDDDIYGETIEIFWLNKIREMVKFNSVNDLVEQLKSDKEIAINWGKS","1082918","For other 'mre' genes see SMu0016 (mreC) and SMu0017 (mreD).","bifunctional protein: riboflavin kinase/flavin adenine dinucleotide (FAD) synthase","Cytoplasm","Several matches in gapped BLAST to macrolide-efflux protein: residues 1-305 are 67% similar to the protein in S.agalactiae (gi2289231) and are 64% similar to the protein from S.pyogenes (gi15675210).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0997 (1e-120).","

InterPro
IPR002606
Family

Riboflavin kinase / FAD synthetase
PD003662	$\"[184-300]T$	FAD_Synth
PF01687	$\"[181-305]T$	Flavokinase
PF06574	$\"[16-165]T$	FAD_syn
TIGR00083	$\"[19-305]T$	ribF

InterPro
IPR006035
Family

Ureohydrolase
PS00148	$\"[3-11]?$	ARGINASE_2

noIPR
unintegrated

unintegrated
G3DSA:2.40.30.30	$\"[163-303]T$	G3DSA:2.40.30.30
PTHR22749	$\"[182-303]T$	PTHR22749
SSF52374	$\"[19-184]T$	SSF52374
SSF82114	$\"[171-305]T$	SSF82114

","BeTs to 10 clades of COG0196COG name: FAD synthaseFunctional Class: HThe phylogenetic pattern of COG0196 is ----yqvceBrhujgp-lin-Number of proteins in this genome belonging to this COG is 1","***** IPB002606 (Riboflavin kinase / FAD synthetase) with a combined E-value of 2.9e-51. IPB002606A 23-32 IPB002606B 55-69 IPB002606C 117-131 IPB002606D 190-211 IPB002606E 220-227 IPB002606F 236-248 IPB002606G 254-296","Residues 1-109 are 62% similar to a (KINASE MACROLIDE-EFFLUX PROTEOME) protein domain (PD202264) which is seen in O34127_STRAG.Residues 181-300 are 82% similar to a (RIBOFLAVIN KINASE FAD PROTEOME) protein domain (PD003662) which is seen in O34127_STRAG.Residues 117-179 are 50% similar to a (RIBOFLAVIN KINASE FAD COMPLETE) protein domain (PD004889) which is seen in O34127_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 12:07:04 2006","Tue Sep 12 12:07:04 2006","Tue Sep 12 12:07:04 2006","Tue Feb 12 10:05:59 2002","Tue Feb 12 10:05:59 2002","Tue Feb 12 10:05:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1045 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 10:05:59 2002","","No significant hits to the NCBI PDB database.","SMU.1143c","","Residues 16 to 165 (E-value = 3.9e-62) place SMu1045 in the Flavokinase family which is described as Riboflavin kinase (Flavokinase) (PF06574)Residues 181 to 305 (E-value = 4.7e-53) place SMu1045 in the FAD_Synth family which is described as Riboflavin kinase / FAD synthetase (PF01687)","Tue Sep 12 12:07:04 2006","24379574","","","Clancy,J., Dib-Hajj,F., Petitpas,J.W. and Yuan,W.Cloning and characterization of a novel macrolide efflux gene,mreA, from Streptococcus agalactiaeAntimicrob. Agents Chemother. 41 (12), 2719-2723 (1997)PubMed: 9420045Clarebout G, Villers C, Leclercq R.Macrolide resistance gene mreA of Streptococcus agalactiae encodes a flavokinase.Antimicrob Agents Chemother. 2001 Aug;45(8):2280-6.PMID: 11451686 Marchandin H, Jean-Pierre H, Jumas-Bilak E, Isson L, Drouillard B, Darbas H, Carriere C.Distribution of macrolide resistance genes erm(B) and mef(A) among 160 penicillin-intermediate clinical isolates of Streptococcus pneumoniae isolated in southern France.Pathol Biol (Paris). 2001 Sep;49(7):522-7.PMID: 11642013 ","","Tue Feb 12 10:12:11 2002","1","","","SMU.1143c","356" "SMu1046","1084736","1083855","882","ATGATTTCAGGAATTATCAATTTAAAAAAAGAAGCAGGGATGACCTCGCACGACGCAGTCTTCAAGCTTCGTAAAATACTAAAAGAAAAAAAAATTGGACACGGGGGAACCTTGGATCCTGATGTTATTGGCGTCCTTCCCATTGCAGTTGGCAAGGCCACACGGGTTCTGGAATACATGACAGAAGCTGGTAAGGTCTATGAAGGTCAAATAACGCTTGGTTTTTCAACAACAACTGAAGATGCTAGCGGTGAGCTTCTCCAATGGACACCAGTTGATGAAACCTTGTCTGTGGAGCTTATTGATCAGGCGATGACATGTTTTATGGGTCAAATCACACAAGTTCCGCCCATGTATTCAGCCGTCAAAGTCAATGGAAAAAAATTATACGAATATGCGCGTGCAGGTCAGGAAGTAGAACGTCCTCAGCGTCAAGTCAGGATTTATGATTTTAAACGGACTAGTGATTTGGTTTTTGAGGATGAATGCTGTCACTTTGATTTTAGGGTTTCTTGCAGCAAGGGAACTTATATCAGAACCTTGGCGGTTGATTTGGGTCAAAAACTTGGCTATGCCAGTCACATGTCCTTCCTAAAACGAACAGCATCAGCTGGTTTAGATTTAAGTCAAGCTTTAACATTAGCTGAAATTGCTGAAAAAGTTGAAGAGAAAGATTTCTCTTTTCTTTTGCCAATAGAATATGGTGTTCTTGATTTACCAAGAATAGACTTAAATCCAAAACAAACCAAAGAAGTTTCTTTTGGAAGACGCCTTAAACTGCTCCGTCAGGAAGAATTGTTAGCAGCTTTTTTTGAAAATCAGCTGGTTGCCGTTTTGGAAAAAAGAGATACCTCTTACAAACCTAAAAAGGTTTTTCTTTGA","7.40","0.79","32945","MISGIINLKKEAGMTSHDAVFKLRKILKEKKIGHGGTLDPDVIGVLPIAVGKATRVLEYMTEAGKVYEGQITLGFSTTTEDASGELLQWTPVDETLSVELIDQAMTCFMGQITQVPPMYSAVKVNGKKLYEYARAGQEVERPQRQVRIYDFKRTSDLVFEDECCHFDFRVSCSKGTYIRTLAVDLGQKLGYASHMSFLKRTASAGLDLSQALTLAEIAEKVEEKDFSFLLPIEYGVLDLPRIDLNPKQTKEVSFGRRLKLLRQEELLAAFFENQLVAVLEKRDTSYKPKKVFL","1083869","For other 'tru' genes see SMu0076 (truA).From Genbank:[gi:13959590]This enzyme is responsible for the formation of pseudouridine at position 55 in the psi GC loop of transfer RNAs","tRNA pseudouridine synthase B","Cytoplasm","Matches in gapped BLAST to tRNA pseudouridine 55 synthase. Residues 1-293 are 67% similar to gi15675211 from S.pyogenes. Residues 2-292 are 63% similar to gi15901075 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0998 (1e-115).","

InterPro
IPR002501
Domain

tRNA pseudouridine synthase B, N-terminal-2
PF01509	$\"[24-178]T$	TruB_N

InterPro
IPR004510
Family

tRNA pseudouridine synthase B
PIRSF004489	$\"[2-291]T$	PSU-B

InterPro
IPR014780
Domain

tRNA pseudouridine synthase B, N-terminal
TIGR00431	$\"[2-217]T$	TruB

noIPR
unintegrated

unintegrated
PTHR13767	$\"[97-264]T$	PTHR13767
SSF55120	$\"[1-238]T$	SSF55120
SSF88697	$\"[239-292]T$	SSF88697

","BeTs to 15 clades of COG0130COG name: Pseudouridine synthaseFunctional Class: JThe phylogenetic pattern of COG0130 is amtkYqvcebrh----olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002501 (Pseudouridylate synthase, TruB family, N-terminus) with a combined E-value of 1e-55. IPB002501A 13-67 IPB002501B 126-141 IPB002501C 172-204 IPB002501B 114-129***** IPB002478 (PUA domain) with a combined E-value of 5.1e-07. IPB002478A 29-43 IPB002478B 175-190","Residues 174-255 are 51% similar to a (SYNTHASE TRNA PSEUDOURIDINE URACIL) protein domain (PD101077) which is seen in TRUB_LACLA.Residues 4-40 are 75% similar to a (SYNTHASE TRNA PSEUDOURIDINE PROCESSING PSI55 URACIL) protein domain (PD006841) which is seen in O32785_BBBBB.Residues 174-217 are 56% similar to a (SYNTHASE TRNA PSEUDOURIDINE PSI55 PROCESSING) protein domain (PD002765) which is seen in TRUB_BACSU.Residues 175-255 are 36% similar to a (SYNTHASE TRNA PSEUDOURIDINE URACIL) protein domain (PD035638) which is seen in TRUB_BUCAI.Residues 44-173 are 69% similar to a (SYNTHASE TRNA PSEUDOURIDINE) protein domain (PD292997) which is seen in O32785_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 12 14:01:29 2006","Tue Sep 12 14:01:29 2006","Tue Sep 12 14:01:29 2006","Tue Feb 12 10:15:57 2002","Tue Feb 12 10:15:57 2002","Tue Feb 12 10:15:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1046 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 12 10:15:57 2002","","No significant hits to the NCBI PDB database.","SMU.1144c","","Residues 21 to 178 (E-value = 6.4e-80) place SMu1046 in the TruB_N family which is described as TruB family pseudouridylate synthase (N terminal domain) (PF01509)","Tue Feb 12 10:15:57 2002","","","","Wrzesinski J, Bakin A, Nurse K, Lane BG, Ofengand J.Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli.Biochemistry. 1995 Jul 11;34(27):8904-13.PMID: 7612632 Searles LL, Jones JW, Fournier MJ, Grambow N, Tyler B, Calvo JM.Escherichia coli B/r leuK mutant lacking pseudouridine synthase I activity.J Bacteriol. 1986 Apr;166(1):341-5.PMID: 3514581 Frendewey DA, Kladianos DM, Moore VG, Kaiser II.Loss of tRNA 5-methyluridine methyltransferase and pseudouridine synthetase activities in 5-fluorouracil and 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur)-treated Escherichia coli.Biochim Biophys Acta. 1982 Apr 26;697(1):31-40.PMID: 6805514","","Tue Feb 12 11:20:52 2002","1","","","SMU.1144c","357" "SMu1047","1086159","1084846","1314","ATGGATACCGTTAAATTTTTTACGAAGTTATTGACCAAGTATGTTCTATTAGTATTTGCCTTAATTGTAGGAGTTATTTTTGTTTATGGCTTGGTTTTCTTAACCTATCTTAATTATTATGGAAAGGAAAAACCAGAGCTAGTTTACACCAAAATCGCTCAATCGAGTCAACAAGATGCGTTCAATATTAGTAAAAGAAGTCAAAAAGAAATGGATAAACAAAAGACTTGGGCTATGGTATTAAATCAAGATGGTCAGATCGTCCAATCTTATCGTTTACCTCAACAGCTCAAAAGACATTATACCAATGCTGATATGGTGAAATTTTCGCGCTGGTATTTAGATGATTATCCTGTTTTTTCCTATGTACGTGGTCAGCAGATTTTAGTTTTTGGCTACCCTAAAAAGTATTCCCTAGCAAAGTTTAATTTTTATCTGAATACGCAATTTATTAAGAATTTTCTTCATTTAGGGTTTGTTTTCTTAGGCATCATCTTTTTATTTATCTTTGTTCTTTTTAGTCATTCAAAGCTGCGCATTAAAAAGGAAATAGAGCCGATTGTCTCTGCGCTCACTTTCTTGTCGCAAGGTCAAAGTGCTGCTCTTAATGAAAAAGGCAATTTTTCTGAAATTAAGACAGCTCTCAATGAAACTTCTCATATTTTAGAAGAAAGTAATATGATGAAAGAACAGTGGATTAGAGGAGTCAGTCACGATTTGCGCAACCCGCTGATGCTGATTTCAGGCTACACCAGTCAATTGGAACAACAATATGGTCATGGAAAGCAAACGGAGCAGATTGAAAATCAGATTCAAAATATGAAAGAAATGATTTCTAATCTTAATTTGAGCTACCTGTTGGATAATCAAAAGCGTCATTCCAAATTTTCAAGCCTTGATTTAGCTGTTGTTCTGCGATCCGTAATTGCTGATATTCTAAATAATTATGAAACAGTTATACTTCATTTTGATTTACCTACAGAGGCAGTATTGGTAAAGGGTGATGCCACTTTATTAGAAAGGGCTTTTAGAAATCTTCTGCTCAATAGTATTAAGCATAGTGGCTCTAATCAGATCGATTTGACTTATCAATTATTTGATAATAAAGTGATTATTATCATTGCAGATAAGGGAACTATTACAGCTCAGAAAATTGTAGAACTAAATCAAAAATCAACTAATTATGAGTCGCATGGCATGGGCACCGTTATCACTAAGCAAATCATAAAACTTCATCAAGGTGAGACTGTCTTTTCAGATAATCATCCAGGTTTGAAAGTGACGATTGTCTTGCCTGTAACGGATGAATTTTAA","9.90","9.90","50382","MDTVKFFTKLLTKYVLLVFALIVGVIFVYGLVFLTYLNYYGKEKPELVYTKIAQSSQQDAFNISKRSQKEMDKQKTWAMVLNQDGQIVQSYRLPQQLKRHYTNADMVKFSRWYLDDYPVFSYVRGQQILVFGYPKKYSLAKFNFYLNTQFIKNFLHLGFVFLGIIFLFIFVLFSHSKLRIKKEIEPIVSALTFLSQGQSAALNEKGNFSEIKTALNETSHILEESNMMKEQWIRGVSHDLRNPLMLISGYTSQLEQQYGHGKQTEQIENQIQNMKEMISNLNLSYLLDNQKRHSKFSSLDLAVVLRSVIADILNNYETVILHFDLPTEAVLVKGDATLLERAFRNLLLNSIKHSGSNQIDLTYQLFDNKVIIIIADKGTITAQKIVELNQKSTNYESHGMGTVITKQIIKLHQGETVFSDNHPGLKVTIVLPVTDEF","1084860","For other 'cov' genes see SMu1377 (covX); SMu1031 (covS); SMu1048 (covR); SMu1378 (covS) and SMu1379 (covR).","histidine kinase related to CovS","Membrane, Cytoplasm","Matches weakly in gapped BLAST to sensor protein : residues 201-436 are 23% similar to the previously published sensor protein CovS in S.mutans (gi14600272). Residues 4-433 are 25% similar to the histidine kinase homolog scnK in S.pyogenes (gi7474192).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2123 (1e-15).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[290-432]T$	ATP_bd_ATPase
PF02518	$\"[334-434]T$	HATPase_c
SM00387	$\"[334-435]T$	HATPase_c
SSF55874	$\"[290-433]T$	ATP_bd_ATPase

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[228-290]T$	HisKA
SM00388	$\"[228-290]T$	HisKA

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[235-435]T$	HIS_KIN

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[218-286]T$	His_kin_homodim

noIPR
unintegrated

unintegrated
PTHR23283	$\"[15-433]T$	PTHR23283
PTHR23283:SF26	$\"[15-433]T$	PTHR23283:SF26

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[7-121]T$	Response_reg
PF00072	$\"[6-118]T$	Response_reg
SM00448	$\"[6-117]T$	REC
PS50110	$\"[7-121]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[146-226]T$	Trans_reg_C
PF00486	$\"[149-226]T$	Trans_reg_C

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[3-192]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[3-157]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[4-123]T$	PTHR23283
PTHR23283:SF21	$\"[4-123]T$	PTHR23283:SF21

noIPR
unintegrated

unintegrated
tmhmm	$\"[33-53]?$	transmembrane_regions

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[85-128]T$	ABC_transporter
PF00005	$\"[1-162]T$	ABC_tran
PS00211	$\"[86-100]?$	ABC_TRANSPORTER_1
PS50893	$\"[1-186]T$	ABC_TRANSPORTER_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-176]T$	G3DSA:3.40.50.300
PTHR19222	$\"[1-176]T$	PTHR19222
PTHR19222:SF16	$\"[1-176]T$	PTHR19222:SF16
SSF52540	$\"[1-181]T$	SSF52540

","BeTs to 12 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.1e-10. IPB001140B 83-121 IPB001140C 138-167","Residues 129-175 are 70% similar to a (ATP-BINDING TRANSPORTER COMPLETE PROTEOME) protein domain (PD000174) which is seen in O34113_LACLA.Residues 42-165 are 27% similar to a (YDR061 ATP-BINDING METAL MEMBRANE) protein domain (PD133621) which is seen in Q9UT95_SCHPO.Residues 33-83 are 66% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD342138) which is seen in O34113_LACLA.Residues 43-165 are 33% similar to a (LACF) protein domain (PD194047) which is seen in Q9RAV2_LACLA.Residues 85-128 are 93% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O34113_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:41:47 2005","Wed Oct 16 08:15:13 2002","Tue May 3 12:41:47 2005","Wed Feb 13 08:37:47 2002","Wed Feb 13 08:37:47 2002","Wed Feb 13 08:37:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1050 is paralogously related (blast p-value < 1e-3) to SMu1649, SMu0596, SMu0944, SMu0950, SMu1920, SMu0374, SMu0216, SMu1003, SMu0335, SMu0666, SMu1518, SMu0976, SMu1762, SMu0390, SMu0884, SMu1093, SMu0418, SMu1949, SMu1517, SMu0971, SMu1023, SMu1380, SMu0849, SMu1068, SMu1751, SMu1410, SMu1950, SMu1036, SMu1210, SMu0218, SMu0907, SMu0235, SMu0234, SMu0517, SMu1811, SMu1079, SMu1246, SMu1231, SMu1037, SMu0594, SMu0731, SMu0786, SMu0805, SMu1428, SMu1710, SMu1757, SMu0258, SMu1064, SMu1001, SMu1288, SMu0476, SMu0825, SMu1545, SMu0987, SMu0916, SMu1306, SMu1316, SMu0164, SMu0824, SMu0752, SMu0986, SMu1959, SMu0836, SMu1065, SMu0837, SMu0823, SMu1724, SMu0475, SMu0729, and SMu0024, all having ATP binding capabilities.","Wed Feb 13 08:38:19 2002","Tue May 3 12:27:01 2005","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 74 2e-014","SMU.1148","","Residues 1 to 162 (E-value = 5.8e-27) place SMu1050 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Feb 13 08:37:47 2002","24379579","","Cvitkovitch,D.G., Gutierrez,J.A., Behari,J., Youngman,P.J.,Wetz,J.E., Crowley,P.J., Hillman,J.D., Brady,L.J. and Bleiweis,A.S.Tn917-lac mutagenesis of Streptococcus mutans to identifyenvironmentally regulated genesFEMS Microbiol. Lett. 182 (1), 149-154 (2000)PubMed: 10612747","Uguen,P., Le Pennec,J.P. and Dufour,A.Lantibiotic biosynthesis: interactions between prelacticin 481 andits putative modification enzyme, lctMJ. Bacteriol. 182 (18), 5262-5266 (2000)PubMed: 10960114PUBMED:10960114Dufour,A., Rince,A., Uguen,P. and Le Pennec,J.P.IS1675, a Novel Lactococcal Insertion Element, Forms aTransposon-Like Structure Including the Lacticin 481 LantibioticOperonJ. Bacteriol. 182 (19), 5600-5605 (2000)PUBMED:10986268","Tue May 3 12:41:47 2005","Wed Feb 13 08:39:49 2002","1","","","SMU.1148","" "SMu1051","1087932","1088672","741","ATGCTCAATTTAGGCTTAGAATTTACTAAATTAAAAAGACGCTCTTTCCTGCTGTCCTTGATTGTCATTATTATCGTGGAATTAGTCTGGATCAGTGTTGTTATCAATCATGAGCTGGCTAATACACATGAAGCCTACAATGCCATCTTTGACATGGCCTACATAAACGACCTTATCCTACCGCTTTTTATTTCTGTTTTGGCATCTAGACTACTGGAAATGGAACACTTGGGTAAGACTTTTAAACTGTTGCAAACCAGCAATGAAAGCCCTTGGCAACTTTTTAAGGCTAAACTAATCTTGATGACCATTTTTACCTTTGTGGTCAGTTGGCTACAAACCATCTTCTTAAAATTCATCATTCAAGCTGCGCAAGTCAAGGTAACACCTGCTCAATTAAGTCTCTCTTTGCTGACAACTTTTTTAGTCTGTATTTTCTTATCTTGCCTTCATCTTTGCTTGGCTTTTATCTACCAAAAAGCAAATGTGACCGTGGTGACAGGTCTAATTGGATCCTTCCTATCATTTGTCGGTATCAGTGCTCTACCCCTACCTATTCGTTTCTTTGTTCCTTGGCAATATTTCTCTATGATGGGAATCGCTAAGCGGATAACAGGGGCTCATACTTACCTTTTCCAATATGATAGTAGCTATCCCTTAAAATTAGTGGCTCTGCTGCTTATCATTCTTTTAGCTATTTTTGTCAGTAAAAAACTTATCGGAAAGGCGGATTTATTATGA","10.20","9.04","27880","MLNLGLEFTKLKRRSFLLSLIVIIIVELVWISVVINHELANTHEAYNAIFDMAYINDLILPLFISVLASRLLEMEHLGKTFKLLQTSNESPWQLFKAKLILMTIFTFVVSWLQTIFLKFIIQAAQVKVTPAQLSLSLLTTFLVCIFLSCLHLCLAFIYQKANVTVVTGLIGSFLSFVGISALPLPIRFFVPWQYFSMMGIAKRITGAHTYLFQYDSSYPLKLVALLLIILLAIFVSKKLIGKADLL","1088680","For other components see SMu1050 (NBD1) and SMu1052 (MSD2).For other 'lct' genes see SMu1018 (lct); SMu1050 (lctF) and SMu1052 (lctG) .","ABC transporter, membrane spanning","Membrane, Cytoplasm","Matches weakly in gapped BLAST to ABC transporters:residues 49-198 are 29% similar to the previously published membrane spanning protein MutE in S.mutans (gi4322368). Residues 49-218 are 31% similar to ABC transporter LctE in Lactococcus lactis subsp. lactis (gi2581773) SMu1051 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-31]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[54-74]?$ $\"[95-115]?$ $\"[134-154]?$ $\"[169-189]?$ $\"[216-236]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 49-198 are 29% similar to a (SUBUNIT EPIE MEMBRANE PLASMID) protein domain (PD115338) which is seen in Q9Z6D9_STRMU.Residues 49-152 are 34% similar to a (LCTE MEMBRANE SCND MUTG) protein domain (PD357441) which is seen in O34114_LACLA.Residues 4-174 are 26% similar to a (PROTEOME COMPLETE GENES CDD1) protein domain (PD232936) which is seen in P94626_CLODI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:49:17 2005","Wed Oct 16 08:17:38 2002","Tue May 3 12:49:17 2005","Wed Feb 13 09:07:16 2002","","Wed Feb 13 09:07:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1051 is paralogously related (blast p-value < 1e-3) to SMu1648, a predicted cdd3-like protein ScnG and SMu1647, a predicted cdd2-like protein ScnG.","Wed Feb 13 09:57:09 2002","","No significant hits to the NCBI PDB database.","SMU.1149","","No significant hits to the Pfam 11.0 database","Wed Feb 13 09:07:16 2002","24379580","","","Uguen,P., Le Pennec,J.P. and Dufour,A.Lantibiotic biosynthesis: interactions between prelacticin 481 andits putative modification enzyme, lctMJ. Bacteriol. 182 (18), 5262-5266 (2000)PubMed: 10960114","Mon Mar 25 13:59:57 2002","Wed Feb 13 09:10:00 2002","1","","","SMU.1149","" "SMu1052","1088669","1089397","729","ATGATAATATTTGAATTTAAAAAAATCAGGAAAAGCGCCATTCCGATAATTCTCATCTTTTTCAATCTTGTCGGAACCTCATTAGGAACAATGATGTTTGCCCTCAATCGCAACTACCTTGTTGATGGAACAGAAGCTTCTATCCTCTGGGGACAAACGGTTTTCTATGCCTCACAAATTTTCACCCCTATCCTCATTGGAACCATATGTTCCATCAGCTGTCAATTCGAAGAAAATAATAAAAACTGGCAGCGGCTCTTAACCATTCCTATCAAACCTAATCGCATCATTTTAACAAAAATCACCAGCTTATCGGTGGTTATGGCCATCAGTCAATTATTGCTGCTATTCTTTTACGTGCTTAGCGCTGTCCTTTTGAAAGTATCTTTTGTAGGTTTTCTGCCAGACTTTTTGCTCTGGTCTATTACAGGCTGGCTGGCGACTATTACTATTGTTACCATTCAAATTTTTATCAATATTCGCCTGAAAAACTTTGCAGTACCTATTCTCATCTCTGCTATTTTGGCAATGGCCGGGCTCATGACCCTTTTTATTGGGAACAGTGTATTTACGATCTTTCCATACGCACAAGTTGCTGTAGGTCTTCGAGCTCGCGCCTTAGTACCTTTTACCCTGCCAGAATTATCCTTGTTTCTAGGACTTAATGTCATCTACATTATTCTCTTTTATGGCTTAGCAGTCAGTCAGCTTAAAAAGAGATTTATCTGA","10.80","10.89","27185","MIIFEFKKIRKSAIPIILIFFNLVGTSLGTMMFALNRNYLVDGTEASILWGQTVFYASQIFTPILIGTICSISCQFEENNKNWQRLLTIPIKPNRIILTKITSLSVVMAISQLLLLFFYVLSAVLLKVSFVGFLPDFLLWSITGWLATITIVTIQIFINIRLKNFAVPILISAILAMAGLMTLFIGNSVFTIFPYAQVAVGLRARALVPFTLPELSLFLGLNVIYIILFYGLAVSQLKKRFI","1089405","For other components see SMu1050 (NBD1) and SMu1051 (MSD1). For other 'lct' genes see SMu1018 (lct); SMu1050 (lctF) and SMu1051 (lctE) .","ABC transporter, membrane spanning","Membrane, Cytoplasm","This sequence corresponds approximately to the previously sequenced gi4322369 in GenBank, a predicted MutG protein. Residues 1-237 are 29% similar to residues 5-240 of this protein.Matches weakly in gapped BLAST to ABC transporters:residues 49-198 are 29% similar to the previously published membrane spanning protein MutG in S.mutans (gi4322369). Residues 1-240 are 41% similar to ABC transporter LctG in Lactococcus lactis subsp. lactis (gi2581775) SMu1052 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[54-76]?$ $\"[96-130]?$ $\"[136-158]?$ $\"[165-185]?$ $\"[215-235]?$	transmembrane_regions

","BeTs to 3 clades of COG1668COG name: ATP-dependent Na+ efflux pump membrane component NatBFunctional Class: CThe phylogenetic pattern of COG1668 is amTk--v--B-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 161-239 are 46% similar to a (LCTG MEMBRANE SCND MUTG) protein domain (PD115336) which is seen in O34115_LACLA.Residues 7-146 are 30% similar to a (LCTE MEMBRANE SCND MUTG) protein domain (PD357441) which is seen in Q9Z6D8_STRMU.Residues 1-146 are 42% similar to a (PROTEOME COMPLETE GENES CDD1) protein domain (PD232936) which is seen in O34115_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:55:23 2005","Wed Oct 16 08:17:04 2002","Tue May 3 12:27:45 2005","Wed Feb 13 10:08:34 2002","","Wed Feb 13 10:08:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1052 is paralogously related (blast p-value < 1e-3) to SMu1647, a predicted cdd2-like protein ScnG.","Wed Feb 13 10:10:00 2002","","No significant hits to the NCBI PDB database.","SMU.1150","","No significant hits to the Pfam 11.0 database","Wed Feb 13 10:08:34 2002","24379581","","","Uguen,P., Le Pennec,J.P. and Dufour,A.Lantibiotic biosynthesis: interactions between prelacticin 481 andits putative modification enzyme, lctMJ. Bacteriol. 182 (18), 5262-5266 (2000)PubMed: 10960114PUBMED 10960114Dufour,A., Rince,A., Uguen,P. and Le Pennec,J.P.IS1675, a Novel Lactococcal Insertion Element, Forms aTransposon-Like Structure Including the Lacticin 481 LantibioticOperonJ. Bacteriol. 182 (19), 5600-5605 (2000)PUBMED 10986268","Tue May 3 12:27:45 2005","Wed Feb 13 10:08:34 2002","1","","","SMU.1150","" "SMu1053","1090883","1089516","1368","ATGATGGCAGATGAAAGAATTGAAGTTTTAAAAGACATTTTATTGGAACTCCATCATGGTGCCAGCGCAGAGTCTGTTCAAGAACGTTTTAATCAGCATTTTAAGGGTGTTTCCGCTATTGAGATTTCCATGATGGAGCATGAACTTATGAATGCTGACACAGGCATTACCTTTGAGGATGTTATGGGACTTTGCAATGTTCATGCCAATCTTTTTAAAGGTGCTATTGCCGATGTTGATGTACCAGATGCTGAGCAGGAAGGGCATCCTGTCAAGGTTTTCAAGGATGAGAATTTGGCTTTACGCGCAGCTATTATGCGTATCCGTCGCATTATTGAAAATTATACTAAACCCGAAAATGAGGACTTTCGTCAGGAAATTCTGAAAGGGCTTAAGCATCAATTTGATTTATTGGGACAATTTTATCATCATTATACTCGCAAGGAAAAACTCTTTTTCCCAATCATGGAACGCTATGGGCATGATTCACCACCTAAGGTGATGTGGGGTGTCGATGATGATATTCGTGATCTTTTCAAAGATGCCAAAGCGACTTTAGCTAAATTGCCTGATGGCTCTATTGAAGAACTTTCTCAAAAATTTGAAGCCTTTGCCAAGGAATTTGAAGAGATGATTTTCAAGGAAGAAGCTATTCTCCTTATGATTCTCTTGGAATCTTTCACTCAGGACGATTGGCTGCAGATTGCTAGCGAGAGTGACGCTTACGGTTATGCCATTCTCAAGCCGACTGAAAAATGGATTCCTCACCGTGAGTCTTTTGATAATGAAGCTGACGCGGACACTTCTGACAACCAACTGGCTGACGCTCTAAATCAAGTGCAAGATGCCAATTCACCTGAGGGGACCAATACAAAAGTTATCAACACACCAGAAGGTCAATTTACTATCACTTTTAAACCTAAGGAAAAAGAAGCAGCAGCAGATCGTACGACCCAACAGCCTTTTGGTAACGGTTATCTATCGGTAGAACAGGCTAATCTCATTCTCAATCATCTGCCACTGGAAATTACCTTTGTCAATAAAGATGATATTTTCCAATATTATAATGACAGTGTTCCTGCAGCAGAAATGGTTTTTAAACGCACACCAAGTCAAGTTGGCCGCAATGTGGAGCTTTGCCATCCACCAAAAGTCTTGGATAAGGTTAAGAAGGTTTTTGAACTCCTACGCAACGGTCAGCGCGATAAGGTTAACATGTGGTTTCAATCTGAACGCCTAGGCAAATTTGTCTATGTGACCTATGCAGCTGTCCGTGACCAAGCAGGAGACTTTCAAGGTGTCCTCGAATATGTACAAGACATCAAACCATTCTTTGAACTAGATAGTGAGTTCAATCGAGATATATAG","4.70","-26.90","52335","MMADERIEVLKDILLELHHGASAESVQERFNQHFKGVSAIEISMMEHELMNADTGITFEDVMGLCNVHANLFKGAIADVDVPDAEQEGHPVKVFKDENLALRAAIMRIRRIIENYTKPENEDFRQEILKGLKHQFDLLGQFYHHYTRKEKLFFPIMERYGHDSPPKVMWGVDDDIRDLFKDAKATLAKLPDGSIEELSQKFEAFAKEFEEMIFKEEAILLMILLESFTQDDWLQIASESDAYGYAILKPTEKWIPHRESFDNEADADTSDNQLADALNQVQDANSPEGTNTKVINTPEGQFTITFKPKEKEAAADRTTQQPFGNGYLSVEQANLILNHLPLEITFVNKDDIFQYYNDSVPAAEMVFKRTPSQVGRNVELCHPPKVLDKVKKVFELLRNGQRDKVNMWFQSERLGKFVYVTYAAVRDQAGDFQGVLEYVQDIKPFFELDSEFNRDI","1089530","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins : residues 2-455 are 62% similar to S.pneumoniae (gi|15900474|) and residues 6-450 are 34% similar to Clostridium acetobutylicum (gi|15894809|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1083 (3e-12).","

InterPro
IPR007380
Domain

Protein of unknown function DUF438
PF04282	$\"[4-89]T$	DUF438

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[112-174]T$	Homeodomain_like

InterPro
IPR012312
Domain

Hemerythrin HHE cation binding region
PF01814	$\"[90-155]T$ $\"[164-222]T$	Hemerythrin

noIPR
unintegrated

unintegrated
SSF55785	$\"[328-434]T$	SSF55785

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 144-259 are 34% similar to a (PROTEOME COMPLETE YQFA) protein domain (PD140902) which is seen in Q9CF71_LACLA.Residues 5-95 are 37% similar to a (PROTEOME COMPLETE BH0228 YQFA) protein domain (PD331943) which is seen in Q9CF71_LACLA.Residues 323-450 are 38% similar to a (PROTEOME COMPLETE YQFA) protein domain (PD339357) which is seen in Q9V002_PYRAB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 13 10:13:55 2002","Wed Feb 13 10:13:15 2002","Wed Feb 13 10:13:15 2002","Wed Feb 13 10:13:15 2002","","Wed Feb 13 10:13:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1053 is paralogously related (blast p-value < 1e-3) to SMu0998, a predicted conserved hypothetical protein.","Wed Feb 13 10:13:55 2002","","No significant hits to the NCBI PDB database.","SMU.1151c","","Residues 4 to 103 (E-value = 2.2e-53) place SMu1053 in the DUF438 family which is described as Family of unknown function (DUF438) (PF04282)","Wed Feb 13 10:13:15 2002","24379582","","","","","","1","","","SMU.1151c","" "SMu1054","1091113","1090880","234","ATGAATAATACAATAGATTTATCAAAACCAGTTGCACAAACGATCAAAGAACATCCCGAAGTTAAGGATATTCTGGTGGAGCTGGGCTTTAAACCTTTGGCAAATCCTGCCATGCTCAATACAGTCGGTAAAGTCACGACCTTGTTGGCTGGCTCTAAAATGGCACGAATTCCTTTGGAAAAGATTAAACAAACTCTAGAATTCAATGGCTATGAAGTGATTGGAGACGAATGA","5.90","-0.77","8446","MNNTIDLSKPVAQTIKEHPEVKDILVELGFKPLANPAMLNTVGKVTTLLAGSKMARIPLEKIKQTLEFNGYEVIGDE","1090894","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypotheticals: residues 1-75 are 64% similar to the protein from S.pneumoniae (gi|15900473|).Residues 5-72 are 33% similar to the protein from Lactococcus lactis subsp. lactis (gi|15673593|).SMu1054 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR015077
Domain

Domain of unknown function DUF1858
PF08984	$\"[5-66]T$	DUF1858

noIPR
unintegrated

unintegrated
SSF51445	$\"[122-281]T$	SSF51445

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[52-91]T$	Acetyltransf_1
PS51186	$\"[7-91]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[5-92]T$	G3DSA:3.40.630.30
SSF55729	$\"[1-91]T$	SSF55729

","BeTs to 3 clades of COG0454COG name: Predicted acetyltransferasesFunctional Class: RThe phylogenetic pattern of COG0454 is AmTKYqVCEBR-uj----in-Number of proteins in this genome belonging to this COG is 8","No significant hits to the Blocks database.","Residues 9-73 are 43% similar to a (PROTEOME COMPLETE BH2609) protein domain (PD283593) which is seen in Q9K9N6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 27 13:21:29 2007","Tue Mar 27 13:21:29 2007","Tue Mar 27 13:22:08 2007","Wed Feb 13 10:23:50 2002","","Wed Feb 13 10:23:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1056 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 13 10:23:50 2002","","No significant hits to the NCBI PDB database.","SMU.1154c","","No significant hits to the Pfam 11.0 database","Wed Feb 13 10:23:50 2002","24379585","","","","","","1","","","SMU.1154c","" "SMu1057","1092763","1093218","456","ATGGTAGTCTTCGTGAGACAGCAAGCCGGCCAGACGATCCCGCAGCTCATCAGTCCTTGTCGGATAGCCCAGTTGCTCATAAAGAGGAAGCAAGGCCTCCAAATCTTCCGGCCTGTATTCTCGAATAGTAAGCGGTTCTTTCACTGCCATCACTCACTTCCTGTCATAATATCTGTAGGACCCAAACGTTACTCCTATCGTTTTTTCCAAAAGTTTATGCAGTCTAGCTTGGCATCCAGGAGGTATATCTTTCTTGAAGACTGCCTCTTCGACTCCATAAGAGACCTCATCGTAACCATAATTATAATGCAAGGGCGCTTCATGATAATGAGAAGTCCCAAATTCGCGAGACTTCCAGTCCAGCAACCCCGATTCTTCCAAGGCACAGCGCAGCTCTTCCACCTTACGTCTGCGCAAAGGAAAGAATTCGTTGCCATTCTCGACCTTACCATTTAA","11.90","16.80","17752","MVVFVRQQAGQTIPQLISPCRIAQLLIKRKQGLQIFRPVFSNSKRFFHCHHSLPVIISVGPKRYSYRFFQKFMQSSLASRRYIFLEDCLFDSIRDLIVTIIIMQGRFMIMRSPKFARLPVQQPRFFQGTAQLFHLTSAQRKEFVAILDLTI","1093226","","hypothetical protein","Cytoplasm, Membrane","No significant hits in gapped BLAST found.SMu1057 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 13 10:25:29 2002","Wed Feb 13 10:25:29 2002","Wed Feb 13 10:25:29 2002","Wed Feb 13 10:25:29 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1057 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 13 10:25:29 2002","","No significant hits to the NCBI PDB database.","SMU.1155","","No significant hits to the Pfam 11.0 database","Wed Feb 13 10:25:29 2002","24379586","","","","","","1","","","SMU.1155","" "SMu1058","1093263","1092916","348","ATGGTGTCTCTTTTGGAAAGATCTTATAGTTTAGAGATTGTTGGTTTAAATGGTAAGGTCGAGAATGGCAACGAATTCTTTCCTTTGCGCAGACGTAAGGTGGAAGAGCTGCGCTGTGCCTTGGAAGAATCGGGGTTGCTGGACTGGAAGTCTCGCGAATTTGGGACTTCTCATTATCATGAAGCGCCCTTGCATTATAATTATGGTTACGATGAGGTCTCTTATGGAGTCGAAGAGGCAGTCTTCAAGAAAGATATACCTCCTGGATGCCAAGCTAGACTGCATAAACTTTTGGAAAAAACGATAGGAGTAACGTTTGGGTCCTACAGATATTATGACAGGAAGTGA","6.90","-0.14","13408","MVSLLERSYSLEIVGLNGKVENGNEFFPLRRRKVEELRCALEESGLLDWKSREFGTSHYHEAPLHYNYGYDEVSYGVEEAVFKKDIPPGCQARLHKLLEKTIGVTFGSYRYYDRK","1092930","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1058 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 13 10:26:40 2002","Wed Feb 13 10:26:40 2002","Wed Feb 13 10:26:40 2002","Wed Feb 13 10:26:40 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1058 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 13 10:26:40 2002","","No significant hits to the NCBI PDB database.","SMU.1156c","","No significant hits to the Pfam 11.0 database","Wed Feb 13 10:26:40 2002","24379587","","","","","","1","","","SMU.1156c","" "SMu1059","1096667","1093482","3186","ATGAAAGATAAAGACACTGAATATGCTAAAAAACTAGCAAAAGATTTAAGTAAATCCATAAAACAACAAAAATTAGTTATTTTTGTTGGTGCAGGAGTTTCTATTTCACAAGGATATCCCAACTGGGATAATTATATTGAACATCTTATTAAGTATTGGCAAGGGCAGATTTTAGCTGAAAGTGACGAGAAAAAGCTTGGTAGAGAGCATCATTTGATTTTTGATTTAATTAGTAAATCTGATATTAGTAATAAACGCAAAGTTGATTTGGTCAACTATGAACTAAAGAATGTTTTTGGTGAAGATTTTGAAAAAAGGCGGTTAGATTTTGAAAGGGGATATTTCAAAAATTTACTTCCCTATTCATTGGTTAATCCGGTATTAGAATCTTTAGCAAGTTTAGATGCAATATTTATAACTTCAAATTATGATTATGAAATTGAAAATCATGCTAAACGTTTAAAAAATACTGTAGTAACAATCAACGATCTAAATGAATTTCAGCATAACAAAAAAGGTAAACTACAATTTGGAGATGTTCTGCATATTCATGGTACCCCTGATTGTGATATAGAGTATTTTGTTAGTTCATCAGCAGATTATTCAAAAACGTATTTAAAAGGTAGAAATAACTTTAATAAATTAGTAAATTGGTTTAAAAAGACAAAACCGACAGTCTTATTTATTGGAGCTAGCCTTGAAGAAGATGAGATCTTATCATTACTTCATGAAGGTAGTCAGAATTATGCATTAATGAAATCAGAAAATACAGGCAATTCAAAAGTTGATGAACACTATAAAAAAATTGTTGAAGGATTTTTTAATTCTGAAAATCATACTCAGATTATATGGTACGGGGATAAATTTAAAGATTTACCGATCTTTGTAGAGAGATTGGTTTCAGATATAAATAAAGAATTGGGAGTACATGAATTTCATAGTGAGTGGAATAATCTTTTAAATCCTTCGAGAGAACAAGAGCAATACAATCAATCTTTAGACAATATTTCGAATGATTCTCATTATCTAACTTCTCTTGTCAATAAAGTTATTGAAATTAATAATAATGATCTAGACAATTTATTATTAAAAGGCATTCTCCAAGGAGAAACACTAGAGAAAATTAGATCTGGTTCATTTCCGGTGTTTTGGAAGTTTATCGCTGAAAATATTGAAAAGCTAAATGATGATGAATGGGAAACAATTTATGGTATTCTTATCCAAGGAAATCAAAGATGTTTCATGGATGATATGTACAAGGTCTATTGTCAAGCGATAGAAAATAACTTATTTGATAACAAGCAGGTGAATGAACTCAGAAAAGTTTTAGCAAGAGATAGAGATGTTATTAATTCTAGTTTCAATCAGGATAATACACTACTAGGCTACTGGTTTGTAAATAGTTTTGAATACAGTAACGACTATTTATATATTACAGATGATCAGGAAATAGAAGTTAATTTAAATTCAGATTGTGTTAAACAATTGAGTCAAATATTAAGTTCTTCTCAGCATTTTAACTATTATTCAATAACTGAATATTTAAAAGAAAATACTAATATTGAATTATTTTATAAACTTGTAAAATCTAACAAATTACTTATTGAAGGAAAAGATTTTATTGAAAATGTTCCTACGAAGCTATTAAAGACTCGATTAGTTCAAAAAATACTAGTTCAAATTGATAATGAAACTGATTTGAATATAGTTTTAGTAAATAGATTAATAGATTTTATTAATTTTTCTGACATTTGCTTTGGAGGAGAACTAAATACATTTGTTGAGAAACACCGAAGTATTATTAGAAATCAAAATAAAGAAATCTTAGAAAAACCTTATCTAAATATGACAATAGGGGAAGGTTTGGTTCCAATTCCACAATTTTCATTTTTAACTCAAGAAGACCTTGCAGGGTATGATGAACCTAAATTGTTAGAGATTTTAGTAAATACAAAAGATGAACAAAGACGTTCATCATTCTTAGAAGAAGAAACTATTTCAGAAACTGAAAACTTCTTAATGAGTATCTTAAAAACTTCAAATGAATTATCTGAAAAAGTTTCTAATCTGTTGGAAAATCATGTTGAAGATTTATATATAAAGTATAAACGACTTTATGTAGAAATTGCTATTTCATCAGAAATCTCGGATGATCTAAGAAATGTAGCCAAAAGAGAATGTTTAGAACGATTTGAAAAAGAGTCCTTTGATAGAAATGATGAAAACTTCTTTAATTACTTTGTGGCTCAGCAAAATGATGAAGAATCAATTTTTGAAAAATTACTTACTGTGGATCCAAATAAGCTATCAACTTTGAGTGATGATAGTGAGCAACTAGATATGTTTCATTTTATAAATAGTGAATTGGGATCATATTTGCAATGTTTGATATCTTTAATTATTCATCATCAGGATTATAGTCCTAAAGTTATTCAGAAAGTCGATGAGATTGAAGATTCAAGTTACAAAGAAATTGCACAAGGCGTCCTTATCAGTGAGTACGACGTTAAAGAAATTGATGTAACATACCATACTTTTTTAGGGTATGCATATTATCATTCCACAGTGACCTCAGAAGCTGCTGAAATTTTTACAGATATTATTAAAAAACTTCTAAAAGAAAAAATTGAAGATAATCAAATTCTAAATAAAGTCTATATGATTGCTTTGGAGTGCATTGACCCAATCAAAGAGCATCTTGAATTATCAAGGAATAATTATGGCATTATGATCAACACTATCTTTATGGAAAAATATGAATTTAAATATTATAAACAGTGGTTACAGGAATTATTTAAACATGATTCAACAGTAAACTATTTAGAAACAATTTCTAATTTGTTGTATCGAGATAACGTTAATAAAGATAGATTAATTCTATTCATTGAGGATCTCAAAAATTATGTATCAAACTATAAATTTAAATTATCTTTGCGTGGAATAAACTATATCTTGAATCAAGAAAACACAAAATATTTTTTTATCATAGGAAAATATTTCGTGTTGTTACTAGAGAATGATAAGTTAGAAAATGATTTCTTTTATTTTGAAACCATAAAAGCTATACTTCCTTTGTTATCTTTAGAGGAAAGGATAAGCGTATTACAAAATATTCAAAAACAAAAAAATTGCCCGCCTCCAGAGATTGAAGAATTACAAAAAATTATCAGTGAATTAAATTCATAA","4.80","-47.71","124709","MKDKDTEYAKKLAKDLSKSIKQQKLVIFVGAGVSISQGYPNWDNYIEHLIKYWQGQILAESDEKKLGREHHLIFDLISKSDISNKRKVDLVNYELKNVFGEDFEKRRLDFERGYFKNLLPYSLVNPVLESLASLDAIFITSNYDYEIENHAKRLKNTVVTINDLNEFQHNKKGKLQFGDVLHIHGTPDCDIEYFVSSSADYSKTYLKGRNNFNKLVNWFKKTKPTVLFIGASLEEDEILSLLHEGSQNYALMKSENTGNSKVDEHYKKIVEGFFNSENHTQIIWYGDKFKDLPIFVERLVSDINKELGVHEFHSEWNNLLNPSREQEQYNQSLDNISNDSHYLTSLVNKVIEINNNDLDNLLLKGILQGETLEKIRSGSFPVFWKFIAENIEKLNDDEWETIYGILIQGNQRCFMDDMYKVYCQAIENNLFDNKQVNELRKVLARDRDVINSSFNQDNTLLGYWFVNSFEYSNDYLYITDDQEIEVNLNSDCVKQLSQILSSSQHFNYYSITEYLKENTNIELFYKLVKSNKLLIEGKDFIENVPTKLLKTRLVQKILVQIDNETDLNIVLVNRLIDFINFSDICFGGELNTFVEKHRSIIRNQNKEILEKPYLNMTIGEGLVPIPQFSFLTQEDLAGYDEPKLLEILVNTKDEQRRSSFLEEETISETENFLMSILKTSNELSEKVSNLLENHVEDLYIKYKRLYVEIAISSEISDDLRNVAKRECLERFEKESFDRNDENFFNYFVAQQNDEESIFEKLLTVDPNKLSTLSDDSEQLDMFHFINSELGSYLQCLISLIIHHQDYSPKVIQKVDEIEDSSYKEIAQGVLISEYDVKEIDVTYHTFLGYAYYHSTVTSEAAEIFTDIIKKLLKEKIEDNQILNKVYMIALECIDPIKEHLELSRNNYGIMINTIFMEKYEFKYYKQWLQELFKHDSTVNYLETISNLLYRDNVNKDRLILFIEDLKNYVSNYKFKLSLRGINYILNQENTKYFFIIGKYFVLLLENDKLENDFFYFETIKAILPLLSLEERISVLQNIQKQKNCPPPEIEELQKIISELNS","1093496","","conserved hypothetical protein","Cytoplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical and to different kinds of proteins: residues 3-1056 are 60% similar to S.pneumoniae (gi|15903136|) and residues 14-273 are 24% similar to hypothetical protein pXO1-13 from B.anthracis (gi|10956260|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1992 (4e-06).","

noIPR
unintegrated

unintegrated
SSF52467	$\"[9-299]T$	SSF52467

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 14-273 are 24% similar to a (PXO1-13 PLASMID) protein domain (PD327657) which is seen in Q9X2Y4_BACAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 13 10:30:19 2002","Wed Feb 13 10:30:19 2002","Wed Feb 13 10:30:19 2002","Wed Feb 13 10:30:19 2002","","Wed Feb 13 10:30:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1059 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 13 10:30:19 2002","","No significant hits to the NCBI PDB database.","SMU.1157c","","No significant hits to the Pfam 11.0 database","Wed Feb 13 10:30:19 2002","24379588","","","","","","1","","","SMU.1157c","" "SMu1060","1097935","1096679","1257","ATGAACGAAATCAAATGTCCGCACTGTGGGACAGTTTTTACCATTAATGAAACGGAATATAGTCAGCTTTTGGCTCAGGTGCGTGGTCAGGAGTTTGAAAGGGAGATTCATGAGCGCCTGCAGCGAGAAACGGCGCTTTTGGAGGAAAAATCCAAGAATGAATTGCAGGTTAATCTCAATGATAAGGACAAGGAGATTGCTGATTTACGGGCGCAATTAGATAAGTTATCCGATAAGAATGCGCTGGAACTTGCTAATGCCTTATCAGAGAAAGACAAGGAAGTGCAGAGCCTGCGAAATCAAGTGGATAAATTACGTTTGGAGCATGAGAATCAGCTGCAAAAAACAGTGGCTCAGATCGAAAAGGAACGTGATGAGGCTCAAAATCAATTGGTGGTGCAGGAAAAAGAATCTGAACTGTCCTTAGCTGCGGTGCGTAGCGATTACGAGGTCCAATTAAAGGCTGCCAATGAACAAGTTGAATTTTATAAAAATTTCAAGGCGCAGCAATCCACCAAGGCCATTGGTGAGAGTCTGGAAGTTTATGCGGAAAGTGAGTTCAACAAAGTTCGCTCTTATGCCTTTCCTAATGCTTATTTTGGCAAGGATAATGAGGTGTCATCTGCTTCTGGTTCCAAGGGGGACTTTATCTTTCGTGAAGCTGATGAGAATGGGGTTGAGATTCTTTCCATCATGTTTGAAATGAAAAACGAGGCTGACACGACTAAAACCAAGCATAAAAACAGTGACTTTTATAAGGAATTGGACAAGGACCGCAGAGAGAAGAAGTGCGAATATGCTGTTTTGGTGACCATGTTAGAGGCTGATAATGATTACTTTAATACAGGCATTGTTGATGTTAGCCATGAGTATGAGAAAATGTACGTAGTGCGGCCGCAGTTCTTTATTCAGTTGATTGGACTTTTGCGCAATGCTGCGCTCAATTCGCTCAAGTACAAGCAGGAGTTGGCTTTAGTTCGTGAACAAAACATTGATATTACGCATTTTGAAGATGATTTGGAAACCTTTAAAAATGCTTTTGCCAAGAACTACAATTCTGCTAGTAAAAATTTCCAAAAGGCCATTGATGAAATTGATAAGGCCATTAAGCGTATGGAAGCGGTTAAGCAGGCACTTCAGACATCAGACAATCAACTGCGCTTGGCCAATAACAAACTTGATGACGTCTCCGTCAAAAAACTGATCCGCAAAAACCCAACCATGAAAGCTAAGTTTGAGGCTTTGAAGGAAGAATAA","5.10","-12.62","48379","MNEIKCPHCGTVFTINETEYSQLLAQVRGQEFEREIHERLQRETALLEEKSKNELQVNLNDKDKEIADLRAQLDKLSDKNALELANALSEKDKEVQSLRNQVDKLRLEHENQLQKTVAQIEKERDEAQNQLVVQEKESELSLAAVRSDYEVQLKAANEQVEFYKNFKAQQSTKAIGESLEVYAESEFNKVRSYAFPNAYFGKDNEVSSASGSKGDFIFREADENGVEILSIMFEMKNEADTTKTKHKNSDFYKELDKDRREKKCEYAVLVTMLEADNDYFNTGIVDVSHEYEKMYVVRPQFFIQLIGLLRNAALNSLKYKQELALVREQNIDITHFEDDLETFKNAFAKNYNSASKNFQKAIDEIDKAIKRMEAVKQALQTSDNQLRLANNKLDDVSVKKLIRKNPTMKAKFEALKEE","1096693","","conserved hypothetical protein","Cytoplasm, Membrane","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-418 are 76% similar to S.pneumoniae (gi|15901076|) and 73% similar to S.pyogenese (gi|15675212|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1000 (1e-178).","

InterPro
IPR003016
Binding_site

2-oxo acid dehydrogenase, lipoyl-binding site
PS00189	$\"[197-226]?$	LIPOYL

","BeTs to 3 clades of COG0419COG name: ATPase involved in DNA repairFunctional Class: LThe phylogenetic pattern of COG0419 is amtkyqvceb------ol---Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 45-189 are 24% similar to a (KINASE ATP-BINDING RHO-ASSOCIATED) protein domain (PD075247) which is seen in P92199_CAEEL.Residues 48-194 are 22% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in CENE_HUMAN.Residues 211-399 are 29% similar to a (MG148 PROTEOME VXPSPT7_ORF445 COMPLETE) protein domain (PD037998) which is seen in Q9PQC4_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 13 10:34:48 2002","Wed Feb 13 10:32:55 2002","Wed Feb 13 10:32:55 2002","Wed Feb 13 10:32:55 2002","","Wed Feb 13 10:32:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1060 is paralogously related (blast p-value < 1e-3) to SMu1375, a predicted chromosome segregation SMC protein and SMu1166, a predicted orotate phosphoribosyltransferase.","Wed Feb 13 10:34:48 2002","","No significant hits to the NCBI PDB database.","SMU.1158c","","No significant hits to the Pfam 11.0 database","Wed Feb 13 10:32:55 2002","24379589","","","","","","1","","","SMU.1158c","" "SMu1061","1098187","1098023","165","ATGTTGGAAGCTATTTTAGAGACCTTGCAGGAGTATTCGCTCAAGGAAGTGAGCGATAAAGAAGAAACAGTCTTTAAGCAGGTTCAGGAATATCTTGCTAGTCACGATTTTATTAAGGGTCAAAGATTTGCAAGGGCTGACAGCATTGAGTCCTGTCAGTTCTAG","4.40","-4.82","6312","MLEAILETLQEYSLKEVSDKEETVFKQVQEYLASHDFIKGQRFARADSIESCQF","1098037","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1061 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 09:47:18 2002","Thu Feb 14 09:47:18 2002","Thu Feb 14 09:47:18 2002","Thu Feb 14 09:47:18 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1061 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 14 09:47:18 2002","","No significant hits to the NCBI PDB database.","SMU.1159c","","No significant hits to the Pfam 11.0 database","Thu Feb 14 09:47:18 2002","24379590","","","","","","1","","","SMU.1159c","" "SMu1062","1099252","1098230","1023","ATGATATTTGACAGTCTTGAAAGTATATTTAATATTTTGGAAAAAATTAATGTTCGTAGGAAACATATTAAGATAGAGTCTATTAACATTACTGATGACAGGAGTAGTAAAGAATACGTTAAAACATTAGGTACTCCAAACGAGAATCATTATTCTAATTTAGTTCATAACATAGTCACTGTTCAAAATAATAGTGGCAAAACACAGGCTATTACAAGTGTTCAATTAAAAAATGTTCAACTTACTTCAAAATCGTTTCCGGTTATTCAATATGATGGTGGTTTTATAAATGACACCCAAGAGTTTTGCTTTATGTTAATTAATAACGGAAATAAAGCAGGACAGACAGCAGATTGTATGGTGAAATTTTACGCTACTGAACAGTCTCAAAAAAAGTATGAATTACTCTTAGAATATCCAATAGAAACACAGGAAATTGAGGAGGGACAAATTAAAGTTGTAGCTTTGGTTGACTATTTGAATAACTTTAAGCAATATTTTGAAGAGAATGATAATGTTAGAGGTATTAGGGTTGAAGTCATTAGAAATGAGAAAGTCTTATTTGACGATGGACAAGGCTATAATAGAGAACAAGGAAGATTTGTGAAACCATTAGGAGGGACTGGAATTCCTATAAATCTTAACAAGACTCTGTTCAGAGTACCCAGAGGATTTAAATTTGAAAAAGAATTAATTCAAAAATGTCATCAGCCCTTAAATATTGGTACAAACACAATTGATTTTTACATTCTAACAGAAGAAACAGCTTCTTTAAACTATGAAGTTGAATTAATAAGTGGAAATAAACGTATCTGTCCTCCTCAAAATGAAGGTAAGATTAAACTTGATGTTTTTGTTCCTTGTTACAAAGTTTTGGATAATCATACTTATGGAAAATTTTATGAGGTACTTGAAAAACAGGGAATTAGGTGTGATGATATATTTACAGTAACAGATATGAAATTAATTAAGGAAGACCTAGTATATAATATATACGAACCATTGGAAAAGATGGATTGGTGA","5.40","-6.05","39395","MIFDSLESIFNILEKINVRRKHIKIESINITDDRSSKEYVKTLGTPNENHYSNLVHNIVTVQNNSGKTQAITSVQLKNVQLTSKSFPVIQYDGGFINDTQEFCFMLINNGNKAGQTADCMVKFYATEQSQKKYELLLEYPIETQEIEEGQIKVVALVDYLNNFKQYFEENDNVRGIRVEVIRNEKVLFDDGQGYNREQGRFVKPLGGTGIPINLNKTLFRVPRGFKFEKELIQKCHQPLNIGTNTIDFYILTEETASLNYEVELISGNKRICPPQNEGKIKLDVFVPCYKVLDNHTYGKFYEVLEKQGIRCDDIFTVTDMKLIKEDLVYNIYEPLEKMDW","1098244","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1062 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 09:50:36 2002","Thu Feb 14 09:50:36 2002","Thu Feb 14 09:50:36 2002","Thu Feb 14 09:50:36 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1062 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 14 09:50:36 2002","","No significant hits to the NCBI PDB database.","SMU.1160c","","No significant hits to the Pfam 11.0 database","Thu Feb 14 09:50:36 2002","24379591","","","","","","1","","","SMU.1160c","" "SMu1063","1100071","1099325","747","ATGGAATACAAAATTTCCCCAGTTTACAGAATGAAATTATTAGAAAAAGTAGAAAAAGAAATTTGGAATCGGTATAAAAGTTATAAAGATGTTGAGCAGTATATGAAACTTAATCAGATATACGATGGGTTTGGGCAAGTTGATTTTGATATTTCTTATTTCAGTGAAGGGAAGAATAAGGAGAAAATTAACCTAATTGAAACATTAAGGGTGATTGCTAAAGATATACCAGATAAATTATTAAAAATGGCCATTGACTTAGGGATTGAAACACCAGACTACATTCCATCTATTCCTACTTTTCGAAATGAACTGAAAGCAGACTATAAAAATGCTTCGACAAGTTTTGAAAAAGCATTCCAAAATATAGAGGAAGACCCTGCTGAATCGGTAGGATATGCAAACTCGGTTCTTGAGAGCATTATCAAGGAAATTTTAAAAGATCAGAGATTTGATATTGATGCGACAAAATTAACAAATGGTAAATTAGTAAAAGCAATTTTAAAGGAATTTGGATTAAATCCTAATAGTCCTCAAATGCCTGATGAAATAAAGAGTATTGGAAGTTCTCTTACGACTGTTTCAAAAGCTATTGAGGATTTGCGGAGTGATAAGACATCATTTCATGGTCATGATTCGGAGAAGTATCTTATTGATGAACCTTTATATGCTTATTTTATTGTCAATGCCTGTGCAACTGTTGGGTTATTTTTGATAAATTTTTACGAAAAGAAATTTCCAAAATAA","5.20","-4.55","28563","MEYKISPVYRMKLLEKVEKEIWNRYKSYKDVEQYMKLNQIYDGFGQVDFDISYFSEGKNKEKINLIETLRVIAKDIPDKLLKMAIDLGIETPDYIPSIPTFRNELKADYKNASTSFEKAFQNIEEDPAESVGYANSVLESIIKEILKDQRFDIDATKLTNGKLVKAILKEFGLNPNSPQMPDEIKSIGSSLTTVSKAIEDLRSDKTSFHGHDSEKYLIDEPLYAYFIVNACATVGLFLINFYEKKFPK","1099339","","conserved hypothetical protein","Cytoplasm","This sequence isn similar to 55823286 in S. thermophilus (Str1374).SMu1063 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[222-242]?$	transmembrane_regions

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[100-219]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[471-513]T$	ABC_transporter
PF00005	$\"[360-544]T$	ABC_tran
PS00211	$\"[471-485]T$	ABC_TRANSPORTER_1
PS50893	$\"[335-568]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[359-545]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[23-304]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[297-566]T$	G3DSA:3.40.50.300
PTHR19242	$\"[5-575]T$	PTHR19242
PTHR19242:SF92	$\"[5-575]T$	PTHR19242:SF92
SSF52540	$\"[335-573]T$	SSF52540
SSF90123	$\"[6-490]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.2e-63. IPB001140A 349-395 IPB001140B 468-506 IPB001140C 521-550","Residues 514-548 are 54% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383) which is seen in Q9KQW9_VIBCH.Residues 471-518 are 45% similar to a (ATP-BINDING ABC TRANSPORT TRANSPORTER) protein domain (PD250423) which is seen in Q9ZNB0_STRCO.Residues 412-468 are 43% similar to a (ATP-BINDING TRANSPORT COMPLETE ABC) protein domain (PD333091) which is seen in Q9PNG4_CAMJE.Residues 415-468 are 48% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC) protein domain (PD054667) which is seen in CYDD_BACSU.Residues 405-468 are 41% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760) which is seen in Q47908_FRANO.Residues 471-553 are 32% similar to a (PYOVERDINE PROTEOME PVDE COMPLETE) protein domain (PD052796) which is seen in Q9I183_PSEAE.Residues 514-573 are 41% similar to a (ATP-BINDING TRANSPORT MULTIDRUG RESISTANCE-ASSOCIATED) protein domain (PD188719) which is seen in AARD_PROST.Residues 406-468 are 50% similar to a (PROTEOME ATP-BINDING FUSION COMPLETE) protein domain (PD268678) which is seen in Q9I4M2_PSEAE.Residues 350-401 are 50% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9KQW9_VIBCH.Residues 150-344 are 18% similar to a (ATP-BINDING TRANSPORT ABC LIPOPROTEIN) protein domain (PD201002) which is seen in Q9ZB57_PROMI.Residues 471-513 are 67% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9EWN7_STRCO.Residues 333-430 are 31% similar to a (COMPLETE ORF MITOCHONDRION PROTEOME) protein domain (PD000146) which is seen in O77308_PLAFA.Residues 56-275 are 24% similar to a (ATP-BINDING MEMBRANE INNER ABC) protein domain (PD310340) which is seen in Q9REN5_ZYMMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 16:04:28 2002","Wed Oct 16 08:19:33 2002","Wed Oct 16 08:19:33 2002","Thu Feb 14 10:14:52 2002","Thu Feb 14 10:14:52 2002","Thu Feb 14 10:14:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1064 is paralogously related (blast p-value < 1e-3) to SMu1065, SMu0825, SMu0986, SMu0837, SMu0475, SMu0258, SMu0476, SMu1710, SMu0824, SMu0836, SMu1724, SMu0987, SMu0024, SMu1950, SMu1949, SMu0418, SMu1920, SMu1757, SMu0731, SMu1288, SMu0907, SMu0916, SMu0849, SMu0390, SMu1316, SMu0218, SMu1003, SMu0517, SMu1079, SMu0971, SMu1428, SMu0805, SMu0786, SMu1380, SMu1518, SMu1246, SMu1231, SMu1762, SMu1023, SMu1210, SMu1001, SMu0884, SMu1068, SMu1036, SMu0235, SMu1751, SMu1037, SMu1093, SMu0234, SMu1545, SMu0596, SMu0823, SMu0164, SMu0594, SMu0374, SMu1410, SMu1517, SMu0335, SMu0216, SMu0950, SMu1649, SMu0224, SMu1686, SMu0976, SMu0944, SMu1811, SMu1306, SMu1050, SMu0729, SMu1959, SMu0752, SMu1202, SMu0666, and SMu1375, all with ATP binding capabilities .","Thu Feb 14 10:19:57 2002","Thu Feb 14 10:14:52 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 65 2e-011pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 64 3e-011","SMU.1163c","","Residues 360 to 544 (E-value = 8.2e-65) place SMu1064 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Feb 14 10:14:52 2002","24379593","","","","Tue Apr 2 17:45:28 2002","Thu Mar 21 13:01:11 2002","1","","","SMU.1163c","" "SMu1065","1103859","1102087","1773","ATGAAGAAAAAATCAACAATGGCTTGGATATCTGAGTTCATTGCACCCTATAGATTTCATTATATAGCAAGTGTGCTTTTAGCCTTTGCTTCCGTTATTTGTGGTTTTCTGCCTTATTTTTATATTGGACGGATTATTCGTGATTTGTTCAATGGTCTTAAAAATGGGCAGCTTTATTTACAAGCATGTCTGTGGATGGCTGTTTTTTGGTTGGCTTATGCCATTTGTCATGCTCTATCAACGGCTCTTTCGCATAGAGCTACTTTTATTGTTTTAGCGGACATTCGTTTTCGTTTAACAGAAAAATTAGCTAAGATTCCTTTAGGATCTGTCTTTGCGCAATCGTCTGGATCCTATAAAAATATTATCGTTGAGCGTGTGGATGAAGCTGAAACAACCCTAGCTCATATTATTCCAGAATTCACGGCGTCCTTATTTGGTCCTTTAATTGTTTTAATTTATATGATAAGATTGGATTGGCGTTTGACCCTTTTATCTCTTTTAACCTTGCCAATCGGCATTTTATTTTATGTCAATATGTTGCGTAAGAGTAAGGGAGATTTTGAAAATACAGTGGTTAAGACTAAGGCTTTAAATGATACAGCTGTTGAATATATCAATGGCATTGAAGTGATCAAGGTATTTGGAAAGGAAAAATTTTCCTATCAGAAATTTGTCACAGCAGCTAAAGAAGGAGCTGACTGTTTTATTGATTGGATGCGTAAGTGTCAATTTGATATGGCAGCAGTCATTGTTATCATGCCTTCGATCTTAGCTATCCTTTTACCTGTTGGTGCTTATTTTGTTTACAGTGGCAGTTTATCCCAAGACAATTTCATTTTACTAATGATTTTATCAATGGGATTGCTGACGCCTTTGATAACACTGGGAACTTATATGGATGACATTAGAAAAGTGGGGACCATTTTTGGTGAAATTACGGAAATTTTGGAACATCCTGATTTACAACGGCCACAAGAATTGGAGCAACCTTTACAAGGAAACGATATTCTTTTAGAAAAGGTTTCTTTTGCCTATGAAGAGGACAAGGATGTACTGCATGATATTTCTTTGACCATCAAATCTGGGACAGTTAATGCCTTGGTCGGTCCTTCTGGCTCTGGGAAGTCCACTTTAGCCAAATTAATTGCTTCTTTCTGGGATGTTAGAACAGGCAGCATTTCTTTTGGCGGACTTGATATCAGAAAGATTCCACTGGAAGAATACAGTCGGCTGATCGCCTATGTTTCTCAGGACAATTTTCTCTTTAATGATAGTATTTTAGAGAATATTCGTTTGGGCAAGCCATCTGCCAGTGATGAAGAGGTTTACCAAGTTGCTAAAGATTGCGGTTGTTATGATTTTATCATGAATCTTGAAAATGGCTTTGCAACGCAGGTTGGTAGTTCTGGCAGCAGCCTGTCTGGCGGTGAACGCCAAAGAATAGCCATTGCCAGAGCCATGCTAAAGGATGCCCCTGTGGTTATTTTGGATGAAGCGACTGCTTATACCGATCCTGAAAATGAAGCTCTGGTACAATCAAGCATTGCACAATTAGTGAAAGATAAAACCTTGATTGTGATTGCCCATCGCCTCTCAACCATTGCTGATGCAGATCAGATTATTTTAGTAAATGAGGGACATATAGAAGCAATTGGCAAGCAAGAAGACTTACTCAAGTCAAGCGACCTCTATCAAAAGATGTGGCAGGCACATTTGTCGGTCAAAGATGCAGACCGTGATGAAAAGATAGGAGGCCTGGCTCATGCTTAG","5.50","-9.88","65637","MKKKSTMAWISEFIAPYRFHYIASVLLAFASVICGFLPYFYIGRIIRDLFNGLKNGQLYLQACLWMAVFWLAYAICHALSTALSHRATFIVLADIRFRLTEKLAKIPLGSVFAQSSGSYKNIIVERVDEAETTLAHIIPEFTASLFGPLIVLIYMIRLDWRLTLLSLLTLPIGILFYVNMLRKSKGDFENTVVKTKALNDTAVEYINGIEVIKVFGKEKFSYQKFVTAAKEGADCFIDWMRKCQFDMAAVIVIMPSILAILLPVGAYFVYSGSLSQDNFILLMILSMGLLTPLITLGTYMDDIRKVGTIFGEITEILEHPDLQRPQELEQPLQGNDILLEKVSFAYEEDKDVLHDISLTIKSGTVNALVGPSGSGKSTLAKLIASFWDVRTGSISFGGLDIRKIPLEEYSRLIAYVSQDNFLFNDSILENIRLGKPSASDEEVYQVAKDCGCYDFIMNLENGFATQVGSSGSSLSGGERQRIAIARAMLKDAPVVILDEATAYTDPENEALVQSSIAQLVKDKTLIVIAHRLSTIADADQIILVNEGHIEAIGKQEDLLKSSDLYQKMWQAHLSVKDADRDEKIGGLAHA","1102101","For other components see SMu1065 (NBD1); SMu1064 (NBD2) and SMu1064 (MSD2).For other 'mut' genes see SMu0510 (mutT); SMu0596 (mutF); SMu0597 (mutE); SMu0598 (mutE);SMu0599 (mutG);SMu0099 (mutR);SMu0738 (mutT); SMu0024 (mutT); SMu0976 (mutF);SMu0986 (mutT);SMu0987 (mutT); SMu1050 (mutF); SMu1052 (mutG); SMu1064 (mutT); SMu1697 (mutY);SMu1700 (mutS2);SMu1291 (mutT); SMu1325 (mutX); SMu1371 (mutR); SMu1468 (mutM); SMu0824 (mutT) and SMu0825 (mutT).","ABC transporter, ATPase component","Membrane, Cytoplasm","Matches weakly in gapped BLAST to ABC transporters:residues 174-552 are 21% similar to the MutT in S.mutans (gi|5918764|). Residues 5-576 are 30% similar to ABC-transporter transmembrane protein in Y.pestis (gi|16121084|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (4e-53).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[131-293]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[478-516]T$	ABC_transporter
PF00005	$\"[363-547]T$	ABC_tran
PS00211	$\"[474-488]T$	ABC_TRANSPORTER_1
PS50893	$\"[337-571]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[362-548]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[22-305]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[300-569]T$	G3DSA:3.40.50.300
PTHR19242	$\"[1-586]T$	PTHR19242
PTHR19242:SF92	$\"[1-586]T$	PTHR19242:SF92
SSF52540	$\"[337-576]T$	SSF52540
SSF90123	$\"[1-493]T$	SSF90123

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[12-25]T$ $\"[33-56]T$	HTHTETR
PF00440	$\"[12-58]T$	TetR_N
PS50977	$\"[6-66]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[1-77]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[3-58]T$	Homeodomain-rel

","BeTs to 7 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 5.7e-11. IPB001647 24-54","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 10:34:46 2002","Thu Feb 14 10:34:46 2002","Wed Oct 16 08:20:48 2002","Thu Feb 14 10:34:29 2002","Thu Feb 14 10:34:29 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1066 is paralogously related (blast p-value < 1e-3) to SMu1294, a predicted transcriptional regulators, AcrR family.","Thu Feb 14 10:52:44 2002","","No significant hits to the NCBI PDB database.","SMU.1165c","","Residues 12 to 58 (E-value = 1e-12) place SMu1066 in the TetR_N family which is described as Bacterial regulatory proteins, tetR family (PF00440)","Thu Feb 14 10:34:29 2002","24379595","","","","","","1","","","SMU.1165c","" "SMu1067","1107307","1104674","2634","ATGAAAAAGAGAATCTATTGGAAAACGATTTATACGTCTTTGCTGCAATCTAAAGGACGTTTTATTTCCATCATGCTTTTGATGTTTCTAGGCTCCTTTACCTTTATTGGTTTGAAGGCAACTAAACCCAATATGCAAACTTTAGCAAGAAATTACCTGCAAACCCATAAAACGGCAGATTTGTTTGTCACAGCTAGCTCTGGTTTTAGTAAAGCCGATCAGACAGAACTGAATAATATCAAAAATGCCCAAATAGACTTTGGCCAAGTAACAGATATGACACTCGCAGGAAAAGATGACGCCATGCGTGTCTTTTCTAAGACTCAATCCCTCTCAACTTATCATGTGGAGTCAGGACGTTTACCCAAAAGGGCTGATGAAATTGCCTTAATTTCAACCTTGAAAAAAAGCTATAAAATAGGAGATACTTTGACTTTTCAATCTTCTGAGAAATCTCTTTTAAAGAGAAGAAAGTTCAAAGTGGTTGGCTTTATCAATTCATCGGAAATATGGTCAACTTTAAACTTAGGCTCATCAACAGCAGGTGATGGGACGCTATCAAGTTATGCTCTGGTCACCTCATCAGCCTTTGCTAACAAGACCAATACCTTAGCGCGCATTCGTTACAATACCTTAAAAAATAGGAATCCTTTTTCTGATGATTACAGCTCAAAAGTTAGTCGTTATCAAGATGACTTAGATAAATTGTTAGAAGATAATGGCAAGAATCGCTTAGCAGAGTTAAAGGAAGCACCACAGGCAAAAGTTAATCAAAGTAAACAAGCCTTAGCAGCAGTTAAAAAACAACTGCAAGAAAAGAAAGCAGCAATCAATAGCTTGCCGGCTTATCAACAAGAGCGGGCGCAAGCCTCTCTTCAAGAAGCAAGTCAGCAACTTGCCCAGAAAGAAAAGCAAGTTCAAAGTGCTCAGGCTAAAATTGACGCTATAGTGGAGCCTACTTACAGTACTTATACACGCTCCACCATGTTAGGTGGTGAGGGCTATACGGTTTACAATTCTAATGCCAATAGTATGGGAAATCTTGGCAATATCTTTCCTATTGTCTTATATGCTGTTGCGGCTTTGGTCACCTTTACGACCATGACACGTTTTGTTGATGAAGAAAGAACTAATTCCGGTGTTTTCAAAGCTTTAGGCTATTCTAATCAAGATGTGATTCGGAAATTTCTCGTCTACGGCTTTGTGGCTAGTTTGATAGGAACAATTCTTGGTATTTTCGGTGGTCATTACCTTTTGGCAAGGATTGTTGCTCAGATTTTTACAGGTAAAATGACCCTTGGTAATCTTCATCTTGCTTTTTATTGGTCCTATAGTCTTATTGCCATTCTCTTAGGTCTTGTTAGTGCTGTCTTGCCAGCCTACTTAATTGCCAGACGAGAATTAAGTGAAAAACCTGCTCAATTATTACTTCCCAAGCCACCAATGAGAGGGGCAAAAATTTTCCTAGAGCGCTTGGGATTTATTTGGAATCATTTGAGTTTTACTCATAAGGTGACAACACGAAATATTTTTCGCTATAAACAGCGGATGCTGATGACCGTCTTTGGTGTTGCGGGTTCTGTTGCTTTGCTCTTTGCAGGCCTTGGCATACAGTCTTCTTTAGGAACAGTTATTAAGGAGCAATTTACGCAGTTAACACCCTATCATCTAGTAGTAAGCAAGAAAGATGGGACTGAAAATGATCAGGAATTGACAGATTTCTTGAAATCAAAAGAGGTCTCTAGCTATCAAAGCCTTTATTATACCCATGTCATGGAAGAAATTCCCCATATTAAGGATCGTCAGTCTGTTGCCATTATGGTATCAGATAAAAAAGACTTTACGGATTTTGTCCATTTAAAAAATGTTGATTCTGGTCATTCGTTGACTTTACCGAAAGAAGGCGTCCTGATTTCTGAAAAATTAGCTCGTTTTTACAAGGTTAAGGCAGGCGATAGCTTTAAATTCAAAGATAGCAAGAGTAAAAAGCGGCAAGTCAAAGTAGCAGCAGTGGTTAAGATGAATGCTGGCCATTATCTCTTTATGACCAAGTCTGCTTATCAAAAGATTTTTGCGGAAAAGCCAGATAACAATGCTTATTTCATCAATCTAAAGAATGATTCTGTTTCTCATATTAAAGATACAGCAACAAAGCTTTTAGCCATGACTAGTGTTGCTTCTGTTACGCAAAATACAGCGCGCATGAAGACCATCAAGACCATTGTGACATCGCTAAATGCTGCTATGACTGTCTTAGTTGTTATTACCATTCTCTTAGCTCTTGTTATTCTTTATAATTTAACCAATATCAATATTGCAGAACGTATTAGAGAACTCTCAACTATTAAAGTTCTCGGATTTTATAATAGAGAAGTAACACTCTATATCTATCGAGAAACGATTGTTCTCTCCTTGGTAGGAATTGCTTTTGGATTATTAGCAGGGCGCTACCTGCATCAATTTATTATGGAAATGATTGGTTCGGATAATGTTATGTTTGGCACAACTGTTGCTGGCACTGTTTATCTTATTCCTGTTTTCTTTATCCTGCTGATTTTGCTCATTTTGGGTTGGCTGATTAATCGCCGTCTGAAAAATCTCGATATGCTAGAAGCTTTGAAGTCAGTGGATTGA","10.60","45.41","98164","MKKRIYWKTIYTSLLQSKGRFISIMLLMFLGSFTFIGLKATKPNMQTLARNYLQTHKTADLFVTASSGFSKADQTELNNIKNAQIDFGQVTDMTLAGKDDAMRVFSKTQSLSTYHVESGRLPKRADEIALISTLKKSYKIGDTLTFQSSEKSLLKRRKFKVVGFINSSEIWSTLNLGSSTAGDGTLSSYALVTSSAFANKTNTLARIRYNTLKNRNPFSDDYSSKVSRYQDDLDKLLEDNGKNRLAELKEAPQAKVNQSKQALAAVKKQLQEKKAAINSLPAYQQERAQASLQEASQQLAQKEKQVQSAQAKIDAIVEPTYSTYTRSTMLGGEGYTVYNSNANSMGNLGNIFPIVLYAVAALVTFTTMTRFVDEERTNSGVFKALGYSNQDVIRKFLVYGFVASLIGTILGIFGGHYLLARIVAQIFTGKMTLGNLHLAFYWSYSLIAILLGLVSAVLPAYLIARRELSEKPAQLLLPKPPMRGAKIFLERLGFIWNHLSFTHKVTTRNIFRYKQRMLMTVFGVAGSVALLFAGLGIQSSLGTVIKEQFTQLTPYHLVVSKKDGTENDQELTDFLKSKEVSSYQSLYYTHVMEEIPHIKDRQSVAIMVSDKKDFTDFVHLKNVDSGHSLTLPKEGVLISEKLARFYKVKAGDSFKFKDSKSKKRQVKVAAVVKMNAGHYLFMTKSAYQKIFAEKPDNNAYFINLKNDSVSHIKDTATKLLAMTSVASVTQNTARMKTIKTIVTSLNAAMTVLVVITILLALVILYNLTNINIAERIRELSTIKVLGFYNREVTLYIYRETIVLSLVGIAFGLLAGRYLHQFIMEMIGSDNVMFGTTVAGTVYLIPVFFILLILLILGWLINRRLKNLDMLEALKSVD","1104688","For other component see SMu1068 (NBD1).For other 'psa' genes see SMu1001 (psaA); SMu1068 (psaA);SMu1069 (psaR); SMu1171 (psaR); SMu1231 (psaA); SMu1752 (psaB) ; SMu1750 (psaR) and SMu1751 (psaA). ","ABC transporter permease","Membrane, Cytoplasm","Matches weakly in gapped BLAST to ABC transporters and to hypothetical protein :residues 8-877 are 30% similar to PsaB in S.mutans (gi15625441). Residues 1-877 are 45% similar to hypothetical protein inS.pyogenes (gi15675215).Residues 3-877 are 36% similar to ABC transporter permease protein from Lactococcus lactis subsp. lactis (gi15673086). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1003 (0.0).","

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[293-472]T$ $\"[699-869]T$	FtsX

noIPR
unintegrated

unintegrated
SSF103473	$\"[407-862]T$	SSF103473

","BeTs to 13 clades of COG0577COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0577 is AMt--QVcEBRHuj--OLinxNumber of proteins in this genome belonging to this COG is 7","***** IPB003838 (DUF214) with a combined E-value of 8.9e-09. IPB003838A 364-411 IPB003838A 764-811","Residues 3-274 are 37% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD401701) which is seen in Q9CGJ2_LACLA.Residues 331-833 are 39% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD147912) which is seen in Q9CGJ2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 10 15:56:13 2006","Mon Jul 10 15:56:13 2006","Mon Jul 10 15:56:13 2006","Thu Feb 14 10:59:33 2002","Thu Feb 14 10:59:33 2002","Thu Feb 14 10:59:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1067 is paralogously related (blast p-value < 1e-3) to SMu1752, SMu1245, SMu1230, SMu1288,all predicted ABC transporters; SMu0787,a predicted conserved hypothetical protein;and SMu1209, a predicted cell-division protein.","Thu Feb 14 11:05:02 2002","","No significant hits to the NCBI PDB database.","SMU.1166c","","Residues 293 to 472 (E-value = 2.1e-29) place SMu1067 in the FtsX family which is described as Predicted permease (PF02687)Residues 699 to 869 (E-value = 5.9e-24) place SMu1067 in the FtsX family which is described as Predicted permease (PF02687)","Mon Jul 10 15:56:13 2006","24379596","","","","Mon Oct 28 10:59:31 2002","","1","","","SMU.1166c","802" "SMu1068","1108024","1107323","702","ATGGCTTATATCGAAATGAAACATTCTTATAAACGTTATCAGATGGGTGAAACCCAAATCATTGCCAATGATGATATTAGTTTTGAAATTGAAAAGGGGGAACTTGTTATCATTTTAGGTGCATCAGGTGCTGGAAAATCAACGGTTCTGAATATTTTGGGTGGAATGGACAATAATGATGAAGGTCAGGTCGTGATTGATGGTGTCAATATTGCAGACTACAATCAAAAGCAGATGACCGCTTATCGCCGCAACGATGTTGGCTTTGTCTTCCAGTTTTATAATTTGGTACCTAATTTAACTGCTAAGGAAAATGTTGAATTGGCTTCGGAAATCGTTAGTCATGCTAAAAATGCAGAAGAGACCTTAAGAGAAGTAGGTTTGGGAGAGCGTTTAAATAACTTTCCTGCACAATTGTCTGGCGGCGAACAGCAACGAGTGTCCATTGCGCGTGCCCTTGCTAAAAATCCTAAATTACTTTTATGTGATGAACCAACAGGTGCTCTGGATTATCAGACTGGAAAGCAAATTCTTAAACTCTTACAAGATATGTCTCGCCAGAAGGACTCAACTGTTGTTATTGTAACCCATAATTCTGCCTTAGCACCACTAGCTAATAGAGTTATTTATCTGCACGACGCTAAGGTAAAAGATGTGAAAATCAATGATCAGCCTCAAGATATTAGAACTCTAGAATATTAA","5.20","-5.08","25911","MAYIEMKHSYKRYQMGETQIIANDDISFEIEKGELVIILGASGAGKSTVLNILGGMDNNDEGQVVIDGVNIADYNQKQMTAYRRNDVGFVFQFYNLVPNLTAKENVELASEIVSHAKNAEETLREVGLGERLNNFPAQLSGGEQQRVSIARALAKNPKLLLCDEPTGALDYQTGKQILKLLQDMSRQKDSTVVIVTHNSALAPLANRVIYLHDAKVKDVKINDQPQDIRTLEY","1107337","For other component see SMu1067 (MSD1). For other 'psa' genes see SMu1001 (psaA); SMu1067 (psaB);SMu1069 (psaR); SMu1171 (psaR); SMu1231 (psaA); SMu1752 (psaB) ; SMu1750 (psaR) and SMu1751 (psaA). ","ABC transporter ATP-binding protein","Cytoplasm, Membrane","Matches weakly in gapped BLAST to ABC transporter ATP-binding protein:residues 4-233 are 59% similar to PsaA in S.mutans (gi|15625442|). Residues 1-233 are 78% similar to ABC transporter ATP-binding protein in S.pneumoniae(gi|15903540|) and are 71% similar to the protein from S.pyogenes (gi|15675216|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1004 (1e-100).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[138-181]T$	ABC_transporter
PF00005	$\"[33-214]T$	ABC_tran
PS00211	$\"[139-153]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-233]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[32-215]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-216]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-213]T$	PTHR19222
PTHR19222:SF32	$\"[4-213]T$	PTHR19222:SF32
SSF52540	$\"[1-216]T$	SSF52540

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[27-60]T$	TetR_N
PS50977	$\"[7-68]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[9-72]T$	Homeodomain_like

InterPro
IPR006662
Domain

Thioredoxin-related
PR00421	$\"[66-74]T$ $\"[74-83]T$ $\"[150-161]T$	THIOREDOXIN

InterPro
IPR011594
Domain

Thioredoxin-like
PD003679	$\"[83-186]T$	Thioredoxin_like

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[4-180]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[1-186]T$	IPR012336

InterPro
IPR013740
Domain

Redoxin
PF08534	$\"[38-186]T$	Redoxin

InterPro
IPR015467
Domain

Thioredoxin family
PTHR10438	$\"[56-92]T$	Trx

noIPR
unintegrated

unintegrated
PTHR10438:SF17	$\"[56-92]T$	PTHR10438:SF17

","BeTs to 14 clades of COG0526COG name: Thiol-disulfide isomerase and thioredoxinsFunctional Class: O,CThe phylogenetic pattern of COG0526 is AMTkYQVCEBRHUJgpoLINXNumber of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 62-172 are 29% similar to a (PROTEOME COMPLETE CG12547 YBDE) protein domain (PD404711) which is seen in Q9C7X1_ARATH.Residues 40-93 are 42% similar to a (COMPLETE PROTEOME CENTER REDOX-ACTIVE) protein domain (PD027685) which is seen in RESA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 13:00:38 2002","Thu Feb 14 12:59:52 2002","Wed Oct 16 08:25:36 2002","Thu Feb 14 12:59:52 2002","","Thu Feb 14 12:59:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1070 is paralogously related (blast p-value < 1e-3) to SMu1699, a predicted thioredoxin.","Thu Mar 21 13:05:38 2002","","No significant hits to the NCBI PDB database.","SMU.1169c","","No significant hits to the Pfam 11.0 database","Thu Feb 14 12:59:52 2002","24379599","","","","","","1","","","SMU.1169c","" "SMu1071","1110099","1109386","714","ATGAATCTTCAACATATTACTATTTTGACACTGTTTATTGAAGGTCTTCTATCATTTTTCTCTCCTTGTGTTTTGCCTATTCTGCCAGTTTATATTGGCATCTTGGCTGGTCAAGGAGAGGAGAAGCAATCTGGAGAAATAATTTGGGATAGGCGAAAAGTCTTTACCAATACATTCTTATTTATTTCTGGCATAGCAGCGACCTTTTTTATTTTGGCTTTTGCTAGCAGCCTTATTAGTCAATTTCTTCAAAGTCATATTCAATTTCTTCAAAATTTGGGCGGAATCTTAATTCTTATTATGGGATTAGTGCAGGTAGGTCTCATTAAATCTCATTTTTTTAACAGGGAATATTCAGCTAAGAATAAAGTCTATCAAGCAGGACAAAAAGTAACCCCTCTCATCGCTTTTTTAATGGGTTTTACTTTTAGTTTTTCTTGGACACCTTGCATTGGTCCGATTTTAGCCAGTGTCTTCTTATATGCTAGCACCCATCAGGGCATTTACAGTGTTTTACTCATTTTGATCTACTGTTTAGGATTTGTTATTCCCTTTGCTTTGATTGCGCTCTTTTCGCAAAGGGTAATGAGCGTTTTTAAGAAACAAAAACGATTTTTAAAATATACCAAATTATTTTCAGGAATTCTTCTTATTCTCATTGGGATTTCTATCTTAACAGGATCATTTGCTAAAATAGCACACTTATTTAATTAA","10.60","12.04","26508","MNLQHITILTLFIEGLLSFFSPCVLPILPVYIGILAGQGEEKQSGEIIWDRRKVFTNTFLFISGIAATFFILAFASSLISQFLQSHIQFLQNLGGILILIMGLVQVGLIKSHFFNREYSAKNKVYQAGQKVTPLIAFLMGFTFSFSWTPCIGPILASVFLYASTHQGIYSVLLILIYCLGFVIPFALIALFSQRVMSVFKKQKRFLKYTKLFSGILLILIGISILTGSFAKIAHLFN","1109400","","cytochrome c-type biogenesis protein","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to cytochrome c-type biogenesis protein: residues 6-210 are 35% similar to the protein in S.pneumoniae (gi|15902947|). Residues 4-208 are 33% similar to the protein from Haemophilus influenzae (gi|16273360|).SMu1071 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003834
Domain

Cytochrome c biogenesis protein, transmembrane region
PF02683	$\"[11-226]T$	DsbD

","BeTs to 10 clades of COG0785COG name: Cytochrome c biogenesis proteinFunctional Class: OThe phylogenetic pattern of COG0785 is a-tk-qvC-brhuj---l---Number of proteins in this genome belonging to this COG is 1","***** IPB003834 (Cytochrome c biogenesis protein transmembrane region) with a combined E-value of 6.4e-08. IPB003834A 12-26 IPB003834B 92-101","Residues 13-197 are 26% similar to a (COMPLETE PROTEOME FROM MER) protein domain (PD254759) which is seen in Q49810_MYCLE.Residues 12-208 are 33% similar to a (CYTOCHROME BIOGENESIS COMPLETE C-TYPE) protein domain (PD003510) which is seen in YE54_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 13:06:39 2002","Thu Feb 14 13:06:20 2002","Wed Oct 16 08:26:39 2002","Thu Feb 14 13:06:20 2002","Thu Feb 14 13:06:20 2002","Thu Feb 14 13:06:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1071 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 14 13:06:20 2002","","No significant hits to the NCBI PDB database.","SMU.1170c","","Residues 11 to 226 (E-value = 5.8e-50) place SMu1071 in the DsbD family which is described as Cytochrome C biogenesis protein transmembrane region (PF02683)","Thu Feb 14 13:06:20 2002","","","","Schiott T, von Wachenfeldt C, Hederstedt L.Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.J Bacteriol. 1997 Mar;179(6):1962-73.PMID: 9068642 ","","Thu Feb 14 13:12:05 2002","1","","","SMU.1170c","" "SMu1072","1111066","1110296","771","ATGCAGTTTGTATTTGATATAGATGGGACGATTTGCTTTGATCGTTTTCAGATAGATGCAAGAATCAAAGCAATTTTAAAAGACGCTGCCAATTATGGGCATCAGATCAGCTTTGCTTCGGCACGCTCTTATCGCGATTGTATAGATGTGTTGGGTCAAGAATTAAGTCAAAAAACGGTCATTGGTTTAAATGGCGGTCTTGCCTATAAAGCTGGGGAATTAATTTTGGAAAAGCCCATGAATCATCGGGCTTTTGACTTGGCTCTTTACTACTGCCATCGCTATCAGCTTCCTTATTTTGTGGATGATGATTTTAATTATGCCCATCATTTGGAACAATTCATCCCTTTTATTCATAGTGTGGATCCTTTAAAACTAGCTAAAGAGGTAGGAGTTGAAGACTTGAAACATCCCATTAAAATGGTTGTTTTCTTTGGCAATCATCTTGATAAAATTGCAGAAGTTAGTCATCATTTAGCTAAACTAGAGCAGCTAGACATAACTTTTCATGATGATGAAAGCTGTCTCTATCTCAATCCTAAAGAAGTCACTAAATCTTCAACGATTCAAGAGCTCTTTGATCATGATTTCGTTGCTTTTGGTAATGATCGCAATGATATCGCTATGTTCCAAGCAGCAGTTTATAGTGTGCAAGTTGGTGATTTTGCAGATTTAAGCCCTTTTGCAGATACGCAAGTATTACTGAGACAAGATTATCATCAAGCAGTGGCAGATAAAATTCACGAAACGTTTGAAAAGTTTCGTGCTTAG","5.30","-11.81","29385","MQFVFDIDGTICFDRFQIDARIKAILKDAANYGHQISFASARSYRDCIDVLGQELSQKTVIGLNGGLAYKAGELILEKPMNHRAFDLALYYCHRYQLPYFVDDDFNYAHHLEQFIPFIHSVDPLKLAKEVGVEDLKHPIKMVVFFGNHLDKIAEVSHHLAKLEQLDITFHDDESCLYLNPKEVTKSSTIQELFDHDFVAFGNDRNDIAMFQAAVYSVQVGDFADLSPFADTQVLLRQDYHQAVADKIHETFEKFRA","1110310","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins:residues 1-220 are 35% similar to S.aureus (gi|15924367|) and residues 1-233 are 35% similar to Pasteurella multocida (gi|15602096|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1133 (8e-60).","

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[3-217]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[2-251]T$	G3DSA:3.40.50.1000
SSF56784	$\"[1-256]T$	SSF56784

","BeTs to 8 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","***** IPB000150 (Cof protein) with a combined E-value of 7.1e-07. IPB000150B 33-42 IPB000150C 198-230","Residues 1-233 are 35% similar to a (PROTEOME COMPLETE PM0231) protein domain (PD400978) which is seen in Q9CP34_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 13:21:30 2002","Thu Feb 14 13:20:14 2002","Thu Feb 14 13:20:14 2002","Thu Feb 14 13:20:14 2002","Thu Feb 14 13:20:14 2002","Thu Feb 14 13:20:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1072 is paralogously related (blast p-value < 1e-3) to SMu0388, SMu0367, and SMu0675, all predicted conserved hypotheticals.","Thu Feb 14 13:21:30 2002","","No significant hits to the NCBI PDB database.","SMU.1171c","","No significant hits to the Pfam 11.0 database","Thu Feb 14 13:20:14 2002","24379601","","","","","","1","","","SMU.1171c","" "SMu1073","1111903","1111163","741","ATGACAACACTTCAAGAAGCCTATCTTGCTTTTAAATCTGCCCAAATTATTGATCTAACACATCAAATAAATGAAAATAGTCCTCATTTTCCATTATTGCCTGCTCTAGAGAAAAAAGATCTCTTTACCTTAAAAGATGGTTTTCATATCCAACAATTTACGGTTGTTGGGCAATATGGCACGCATATTGATGCACCTATTCATTTTGTTGAAGGCGGTGCTTGGTTAGATGAACTTCCTCTGGAAGATCTCCTTTTACCGATGTATGTCATAGATAAGTCACAGGCTGTTGCTGATAATCCTAACTATGAATTGAGCAAGGCTGATATTCTTGCCTTTGAGGAAAAGTATGGTCAAATTGAAGAAGGGGCTTTTGTTGCTTTTCGCAGTGATTGGTCAAAACGCTGGCCTAGTCAAGAGGAATTTAGAAATCTTGATACTGCAGGTGCTCAACAGACACCTGGCTGGAGTCATGAAGCTTTGGAATTTCTGATTCATGAACGTCAAGTAAAAGCAGTAGGACACGAAACTTTTGATACAGACAGCGGCCAAGCAGTTGCTGAAAATGGAAAATTAGTTGAGGAATATTATCTGCTGGATCAGGGAATTTATCAATTGGAAGTTTTAAACAACCTTAATCTCCTACCTGCTACTGGTAGTTTCATTTCGATTGCTTATCCTCATTGGGAAAAAGCAACAGGTTCTCCTGTTAGAGCCATCGCTTACATTGCGCAGGAGTAA","4.50","-18.81","27752","MTTLQEAYLAFKSAQIIDLTHQINENSPHFPLLPALEKKDLFTLKDGFHIQQFTVVGQYGTHIDAPIHFVEGGAWLDELPLEDLLLPMYVIDKSQAVADNPNYELSKADILAFEEKYGQIEEGAFVAFRSDWSKRWPSQEEFRNLDTAGAQQTPGWSHEALEFLIHERQVKAVGHETFDTDSGQAVAENGKLVEEYYLLDQGIYQLEVLNNLNLLPATGSFISIAYPHWEKATGSPVRAIAYIAQE","1111177","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-246 are 48% similar to gi|15601962| from Pasteurella multocida residues 12-241 are 47% similar to gi|15923345| from S.aureus. SMu1073 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007325
Family

Putative cyclase
PF04199	$\"[16-229]T$	Cyclase

noIPR
unintegrated

unintegrated
SSF102198	$\"[12-244]T$	SSF102198

","BeTs to 6 clades of COG1878COG name: Uncharacterized ACR, predicted metal-dependent hydrolasesFunctional Class: RThe phylogenetic pattern of COG1878 is amT---vc--rh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-246 are 48% similar to a (PROTEOME COMPLETE PM0097) protein domain (PD400935) which is seen in Q9CPE7_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 13:31:33 2002","Thu Feb 14 13:31:33 2002","Thu Feb 14 13:31:33 2002","Thu Feb 14 13:31:33 2002","","Thu Feb 14 13:31:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1073 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 14 13:31:33 2002","","No significant hits to the NCBI PDB database.","SMU.1172c","","Residues 16 to 229 (E-value = 2e-53) place SMu1073 in the Cyclase family which is described as Putative cyclase (PF04199)","Thu Feb 14 13:31:33 2002","24379602","","","","","","1","","","SMU.1172c","" "SMu1074","1113230","1111917","1314","ATGGAGCTAATTAATAATAAAAGGAGAGCTTCCATGACTCGAGAATTTTCTTTTGAAACTTTACAATTACATGCGGGACAAAGTGTTGATCCTACAACAAAATCGCGTGCAGTACCAATCTATCAGACGACTTCCTATGTGTTTAATGATGCACAAGATGCTGAAGATTCTTTTGCACTTCGTACACCCGGCAATATTTATACGCGGATCACTAATCCGACTACAGCCGTTTTTGAAGAACGGATGGCCGCTCTTGAAGGTGGTGTCGGTGCACTGGCAACAGCTTCTGGTATGGCAGCAGTAACTTATATTGCCTTGGCTCTTGCTCATGCAGGTGATCATATTGTGTCAGCAGCGACAGTTTACGGTGGCACTTTTAATCTTCTTAAGGAAACTTTACCTCGCTATGGCATTACTACAAGTTTTGTTGATGTTGCTAATTTCGCTGAAATTGAAGCGGCTATTACAGACAAGACTAAGTTTATTATCGCTGAAACGTTAGGAAATCCTCTTGGAAATATCGCTGATCTTGAAAAATTAGCTGAGATTGCCCATCGACATGCTATTCCCTTGGTTATTGATAATACCTTTGGTACTCCTTATTTGCTTAATGTCTTCTCTTACGGTGTTGATATTGCTGTTCATTCTGCCACTAAATTTATCGGTGGACATGGGACATCTATTGGCGGTGTCATTGTTGATTCTGGAAACTTTGATTGGGAAAAATCTGGAAAATTCCCACAATTTGTAGAACCAGATCCTTCCTATCATGACATTAGTTATACACGTGATATTGGAAAAGCAGCTTTTGTAACTGCGGTGCGTACGCAACTGCTGCGTGATACAGGCGCCTGCCTTTCACCTTTCAATGCCTTTCTTTTGCTACAAGGTCTAGAAACCTTATCACTTCGTGTTGAGCGTCATGTGGAAAATGCTAAGAAAATTGCGTACTATCTGGAAAATCATCCTAAAGTCACAAAAGTTAATTATGCTAGTTTGCCATCAAGTCCTTATTATGACTTGGCTCAAAAATACTTGCCAAAAGGAGCTAGTTCTATCTTTACTTTTAATGTTGCAGGCAGTGCGAAAGCCGCTCGCGAGGTCATTGACAGTCTTGAAATCTTTTCTGATTTGGCGAATGTTGCTGATGCCAAATCACTAGTTGTTCATCCGGCAACAACCACTCATGGTCAAATGACTGAAGAAGATCTACGAGCTTGCGGTATTGAACCTGAGCAAATCCGTGTTTCTATTGGTTTGGAAAATGCTGATGACTTAATCGAAGATTTGCGCCTAGCACTTGAAAAAATATAA","5.20","-12.17","47448","MELINNKRRASMTREFSFETLQLHAGQSVDPTTKSRAVPIYQTTSYVFNDAQDAEDSFALRTPGNIYTRITNPTTAVFEERMAALEGGVGALATASGMAAVTYIALALAHAGDHIVSAATVYGGTFNLLKETLPRYGITTSFVDVANFAEIEAAITDKTKFIIAETLGNPLGNIADLEKLAEIAHRHAIPLVIDNTFGTPYLLNVFSYGVDIAVHSATKFIGGHGTSIGGVIVDSGNFDWEKSGKFPQFVEPDPSYHDISYTRDIGKAAFVTAVRTQLLRDTGACLSPFNAFLLLQGLETLSLRVERHVENAKKIAYYLENHPKVTKVNYASLPSSPYYDLAQKYLPKGASSIFTFNVAGSAKAAREVIDSLEIFSDLANVADAKSLVVHPATTTHGQMTEEDLRACGIEPEQIRVSIGLENADDLIEDLRLALEKI","1111931","For other 'cys' genes see SMu0141 (cysS) and SMu0449 (cysK).","O-acetylhomoserine sulfhydrylase","Cytoplasm","Several matches in gapped BLAST to O-acetylhomoserine sulfhydrylase : residues 60-437 are 74% similar to the enzyme in S.pneumoniae (gi:15903138). Residues 11-436 are 59% similar to the protein from Clostridium acetobutylicum (gi:15896038).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1098 (7e-04).","

InterPro
IPR000277
Family

Cys/Met metabolism pyridoxal-phosphate-dependent enzymes
PTHR11808	$\"[106-238]T$ $\"[273-437]T$	Cys_Met_Meta_PP
PF01053	$\"[19-435]T$	Cys_Met_Meta_PP
PS00868	$\"[211-225]T$	CYS_MET_METAB_PP

InterPro
IPR002197
Domain

Helix-turn-helix, Fis-type
PR01590	$\"[102-119]T$ $\"[119-139]T$	HTHFIS

InterPro
IPR006235
Family

O-acetylhomoserine/O-acetylserine sulfhydrylase
PTHR11808:SF12	$\"[106-238]T$ $\"[273-437]T$	OAH_OAS_sulfhy
TIGR01326	$\"[17-435]T$	OAH_OAS_sulfhy

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[9-301]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015422
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 2
G3DSA:3.90.1150.10	$\"[302-435]T$	PyrdxlP-dep_Trfase_major_sub2

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[7-437]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PIRSF001434	$\"[20-437]T$	CGS

","BeTs to 7 clades of COG0626COG name: Cystathionine beta-lyases/cystathionine gamma-synthasesFunctional Class: EThe phylogenetic pattern of COG0626 is ---kY-VcEBRHuj-------Number of proteins in this genome belonging to this COG is 2","***** IPB000277 (Cys/Met metabolism pyridoxal-phosphate-dependent enzymes) with a combined E-value of 2.3e-83. IPB000277A 64-85 IPB000277B 157-190 IPB000277C 194-229 IPB000277D 283-323 IPB000277E 380-396 IPB000277F 413-430","Residues 19-435 are 57% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9CJC4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon May 23 10:54:15 2005","Thu Feb 14 13:35:52 2002","Mon May 23 10:54:15 2005","Thu Feb 14 13:35:52 2002","Thu Feb 14 13:35:52 2002","Thu Feb 14 13:35:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1074 is paralogously related (blast p-value < 1e-3) to SMu1527, a predicted cystathionine gamma-synthase and SMu0226, a predicted NifS protein homolog, class-V aminotransferase.","Thu Feb 14 13:41:08 2002","Mon May 23 10:54:15 2005","pdb1QGNA Chain A, Cystathionine Gamma-Synthase From Nicotiana... 201 1e-052pdb1CS1A Chain A, Cystathionine Gamma-Synthase (Cgs) From Esc... 188 1e-048pdb1CL2A Chain A, Cystathionine Beta-Lyase (Cbl) From Escheri... 131 2e-031","SMU.1173c","","Residues 19 to 435 (E-value = 1e-198) place SMu1074 in the Cys_Met_Meta_PP family which is described as Cys/Met metabolism PLP-dependent enzyme (PF01053)Residues 49 to 393 (E-value = 8.4e-06) place SMu1074 in the DegT_DnrJ_EryC1 family which is described as DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041)","Mon May 23 10:54:15 2005","","","","","","","1","","","SMU.1173c","" "SMu1075","1115712","1113511","2202","ATGGCAGGTGCAGGGTCGGGTAAGACACGTGTTTTAACCCATCGCATTGCTTATTTGATTGATGAGAAGTTTATCAATCCTTGGAATATTTTAGCCATTACCTTTACCAATAAAGCTGCGCGTGAAATGAAAGAACGTGCTTTTGCTCTAAATGCTGCGACACAGGAGACTTTAATTGCGACTTTTCATTCTATGTGCGTACGGATTTTACGTCGTGATGCAGATCATATTGGTTACAACCGTAACTTTACTATTGTTGATCCCGGTGAACAACGCACGCTTATGAAGCGTATTTTTAAGAATTTTAATATAGACTCTAAAAAGTGGAATGAGCGTGCTGTCTTAGCTGCCATTTCCAATGCTAAAAACGATTTACTTGATGAAATCGCTTATGAAAATAGGGCGGGGGATTCATATACACAGCTTGTCGCTAAATGCTATAAGGCCTACCAAAGTGAACTGCGTCAATCGGAAGCTATGGACTTTGATGACCTCATTATGCTGACCTTGCGTCTTTTTGACCAAAATCCTGATGTTTTGGCTTATTATCAGCAGCGTTACCAGTATATTCATGTGGATGAGTATCAAGATACTAACCATGCCCAGTATCAGCTGGTTAAGCTTTTGGCTTCACGATTTAAAAATATTTGTGTGGTTGGGGATGCTGATCAGTCTATTTATGGTTGGCGTGGTGCTGATATGCAGAATATCCTTGATTTTGAAAAGGATTATCCTGAGGCTAAGGTAGTGCTCTTGGAGGAGAACTATCGCTCTTCCAAGAAGATTTTGCAAGCTGCCAATGATGTTATTAAAAATAATCGTAATCGCCGAGATAAGAAACTCTGGACGCAAAATGATGATGGAGAGCAGATCGTTTATTATCGGGCAGATGATGAACAGGATGAGGCTGTTTTTGTCGCCTCAACTATTGCTAATATTGTTCGTGAAATGGGGAAAAATTTTAAGGATTTCGCAGTTCTTTATCGTACCAATGCGCAGTCACGTACCATTGAAGAGGCTCTGCTTAAGTCCAATATTCCCTACACTATGGTTGGCGGGACTAAGTTTTACAGCCGCAAGGAAATTCGTGATATTATCGCTTATTTGAATGTAATTGCTAACACTGCCGACAATATCTCCTTTGAGCGTATTGTCAATGAACCCAAGCGCGGTGTTGGACCAGGGACTCTGGAAAAAATTCGTAACTTTGCTAATCTGCAGGGCATGAGTCTGTTAGAAGCTTCTGAAAATATCATGCTCTCTTCCATCAAGGGAAAGGCTGTACAAGCAGTTTATGAGCTGGCTAATATGATAATAGACTTGCGTTCTAAACTGGATCATTACAGCATTACAGAAGTTGTTGAAGCAGTTCTAGACAGTTCTGGTTACCTTGAGGTTTTAGAGATTCAAAAGACTCTGGAAAGTCAGACTCGGATTGAAAATATAGAAGAGTTTCTTTCTGTTACCAAAAATTTTGACGATACGACTGATGATGTTCCTGAAAATGAAACAGGTCTTGAAAGGTTAAGTCGCTTTCTTAATGATTTAGCTTTGATTGCTGATACAGATGAAGCTGAAAGTGAGTCAGCTGAAGTCACCCTGATGACGCTGCATGCTGCTAAGGGACTGGAATTTCCAATAGTCTTCCTTATTGGACTTGAAGAGGGTGTATTTCCTTTGTCGCGCTCCATGGAAGAAGAAAGCGAACTGGAAGAAGAGCGCCGTCTGGCTTATGTTGGAATCACGCGAGCGGAACAAATGCTTTTTATCACCAACGCTAATTCTCGCACACTTTATGGCCGTACTAGCTACAATCGCGAAAGTCGCTTTATTCAGGAAATTTCAGAAGATTTGCTGGTGCATCAGGGATTGGCGCGTCCAGCCAGAGCTTCCTTTAAAGTTAGTTATCAAGACAGCAATGAAACTAAATTTGGTCAAGGAATGAGTCTGGCTCAGGCTTTACAGGCTCGAAAAGTTGCTTCACAGCCTAAGAAGTCTCCTTTTTCAAATAGCAAGGATGATCAGAAAGAACACATTGATTGGCAAATTGGCGATACTGCTCATCATAAGAAATGGGGAGATGGCACTGTCTTAGAAGTTTCGGGCAGTGGAAGTGCTCAGGAACTGAAAATTAAATTCCCAGAAATTGGCTTGAAAAAAGTTTTGGCTAGTGTAGCACCCCTTGAGAAAAAGGAGACATAA","5.30","-15.39","83455","MAGAGSGKTRVLTHRIAYLIDEKFINPWNILAITFTNKAAREMKERAFALNAATQETLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRIFKNFNIDSKKWNERAVLAAISNAKNDLLDEIAYENRAGDSYTQLVAKCYKAYQSELRQSEAMDFDDLIMLTLRLFDQNPDVLAYYQQRYQYIHVDEYQDTNHAQYQLVKLLASRFKNICVVGDADQSIYGWRGADMQNILDFEKDYPEAKVVLLEENYRSSKKILQAANDVIKNNRNRRDKKLWTQNDDGEQIVYYRADDEQDEAVFVASTIANIVREMGKNFKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNVIANTADNISFERIVNEPKRGVGPGTLEKIRNFANLQGMSLLEASENIMLSSIKGKAVQAVYELANMIIDLRSKLDHYSITEVVEAVLDSSGYLEVLEIQKTLESQTRIENIEEFLSVTKNFDDTTDDVPENETGLERLSRFLNDLALIADTDEAESESAEVTLMTLHAAKGLEFPIVFLIGLEEGVFPLSRSMEEESELEEERRLAYVGITRAEQMLFITNANSRTLYGRTSYNRESRFIQEISEDLLVHQGLARPARASFKVSYQDSNETKFGQGMSLAQALQARKVASQPKKSPFSNSKDDQKEHIDWQIGDTAHHKKWGDGTVLEVSGSGSAQELKIKFPEIGLKKVLASVAPLEKKET","1113525","From Genbank:[gi:7674149]This enzyme is used for plasmid rolling-circle replication and also involved in UV repair.","ATP-dependent DNA helicase","Cytoplasm","Several matches in gapped BLAST to ATP-dependent DNA helicase: residues 1-731 are 73% similar to the enzyme in S.pyogenes (gi|15675225|) and are 75% similar to the protein from S.pneumoniae (gi|15900955|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1142 (0.0).","

InterPro
IPR000212
Family

UvrD/REP helicase
PTHR11070	$\"[1-444]T$ $\"[461-728]T$	UvrD_helicase
PF00580	$\"[1-463]T$	UvrD-helicase

InterPro
IPR005751
Family

ATP-dependent DNA helicase PcrA
TIGR01073	$\"[1-729]T$	pcrA

InterPro
IPR014016
Domain

Helicase superfamily 1, UvrD-related
PS51198	$\"[1-259]T$	UVRD_HELICASE_ATP_BIND

InterPro
IPR014017
Domain

UvrD-like DNA helicase, C terminal
PS51217	$\"[260-542]T$	UVRD_HELICASE_CTER

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-250]T$ $\"[253-623]T$	G3DSA:3.40.50.300
SSF52540	$\"[1-623]T$	SSF52540

","BeTs to 14 clades of COG0210COG name: Superfamily I DNA and RNA helicasesFunctional Class: LThe phylogenetic pattern of COG0210 is --T-YqvCEBRHUJgPOLinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000212 (UvrD/REP helicase) with a combined E-value of 4.4e-72. IPB000212A 2-12 IPB000212B 30-47 IPB000212C 192-203 IPB000212D 219-232 IPB000212E 252-270 IPB000212F 532-550 IPB000212G 572-584","Residues 683-730 are 64% similar to a (HELICASE DNA II PROTEOME) protein domain (PD011354) which is seen in Q9CGH6_LACLA.Residues 532-614 are 51% similar to a (HELICASE DNA COMPLETE PROTEOME ATP-DEPENDENT ATP-BINDING) protein domain (PD002094) which is seen in Q9KY67_STRCO.Residues 1-50 are 88% similar to a (HELICASE DNA PROTEOME COMPLETE ATP-BINDING DNA-BINDING) protein domain (PD000627) which is seen in Q9CGH6_LACLA.Residues 301-406 are 30% similar to a (HELICASE ATP-DEPENDENT DNA PROTEOME) protein domain (PD126511) which is seen in Q9FCK4_STRCO.Residues 346-494 are 63% similar to a (HELICASE DNA PROTEOME COMPLETE ATP-DEPENDENT 3.6.1.- II) protein domain (PD003735) which is seen in Q9CGH6_LACLA.Residues 150-247 are 38% similar to a (HELICASE COMPLETE PROTEOME DNA) protein domain (PD126505) which is seen in Q9FCK5_STRCO.Residues 61-124 are 39% similar to a (HELICASE DNA II PROTEOME) protein domain (PD310960) which is seen in Q9KVF6_VIBCH.Residues 55-331 are 73% similar to a (HELICASE DNA PROTEOME COMPLETE ATP-DEPENDENT ATP-BINDING) protein domain (PD001658) which is seen in Q9CGH6_LACLA.Residues 598-682 are 41% similar to a (HELICASE PROTEOME 3.6.1.- COMPLETE) protein domain (PD390704) which is seen in Q9CGH6_LACLA.Residues 1-114 are 30% similar to a (DOMAIN OF UNKNO N) protein domain (PD277160) which is seen in Q9SW14_ARATH.Residues 2-46 are 50% similar to a (HELICASE COMPLETE PROTEOME NUCLEASE) protein domain (PD366909) which is seen in Q9K8M6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 15:01:29 2002","Thu Feb 14 14:54:27 2002","Wed Oct 16 08:29:58 2002","Thu Feb 14 14:52:02 2002","Thu Feb 14 14:52:02 2002","Thu Feb 14 14:52:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1075 is paralogously related (blast p-value < 1e-3) to SMu1363, a predicted ATP-dependent exonuclease, subunit A.","Thu Feb 14 15:03:02 2002","Thu Feb 14 14:52:02 2002","pdb|3PJR|A Chain A, Helicase Substrate Complex >gi|2781090|pdb|... 724 0.0pdb|2PJR|A Chain A, Helicase Product Complex >gi|9257173|pdb|2P... 598 1e-171pdb|1UAA|B Chain B, Structure Of The Rep Helicase-Single Strand... 377 2e-105","SMU.1174c","","Residues 1 to 463 (E-value = 4.2e-193) place SMu1075 in the UvrD-helicase family which is described as UvrD/REP helicase (PF00580)","Thu Feb 14 14:52:02 2002","","","","Petit,M.A., Dervyn,E., Rose,M., Entian,K.D., McGovern,S.,Ehrlich,S.D. and Bruand,C.PcrA is an essential DNA helicase of Bacillus subtilis fulfillingfunctions both in repair and rolling-circle replicationMol. Microbiol. 29 (1), 261-273 (1998)PubMed: 9701819","","Thu Feb 14 14:58:49 2002","1","","","SMU.1174c","127" "SMu1076","1116158","1117522","1365","ATGTTAACATTTTTTAAAGCTCTAGACAGCCTTGTCTGGGGTGCTCCCCTATTAGTTCTTTTAGTCGGTACTGGAATTTATTTGAGTACTCGCTTAAGATTATTGCAGGTGTTGAAACTCCCTTTAGCCTTTAAACTCATCTTTGCCGAGGACAAAGGGGAAGGTGATATTTCGAGTTTTGCGGCTTTAGCTACCGCTCTTGCTGCCACTGTTGGAACTGGAAATATCGTTGGTGTTGCCACTGCAATCAAAGCTGGCGGTCCGGGAGCACTCTTTTGGATGTGGATAGCAGCTTTTTTTGGTATGGCAACTAAATATGCCGAAGGTCTTCTGGCTATAAAATACCGTACTAAGGATGCTAACGGAGAAGTCTCTGGCGGACCTATGTACTATATCATAAACGGTATGGGGAAAAAATGGAAACCTTTAGCTATCTTCTTTGCATTGGCAGGTATCTTAGTGGCATTTTTAGGAATTGGTACCTTTTCTCAGGTCAATTCAATTACTGCTTCCCTAAAAAATAGTTTTAATTGGTCACCGCAGATTGTCAGCATCTTAATTGCCATTGTTGTTGCTGTTATTATTTTCGGCGGTATCCAATCAATTGCAAAGGTTTCTGAGAAATTAGTTCCTTTCATGGCTGCAGCTTACATCATCGCAACCTTGATCGTCATTTTTATGCACTACAATCATATCATTCCTGCCATTGAACAAGTCTTCTCTGGAGCTTTCACAGGGACAGCCGCAGTTGGTGGCTTTGCTGGTGTTGTTGTGAAAGAAGCCATTCAAAATGGTATTGCTCGTGGTGTCTTCTCCAATGAATCTGGTCTAGGTTCTGCTCCAATCGCCGCTGCGGCTGCTAAAACTCATGAACCTGCTGAACAGGGCCTCATTTCAATGACAGGCACTTTTATTGATACTCTCGTCATTTGTACCTTAACTGGTCTTTCTATCTTGGTCACTGGAAAATGGACTGTCAAAGGACTTGAAGGTGCTCCACTGACACAATCAGCCTTTGCAACTGTTTTTGGCAATATAGGCGTTCTAGTGCTGACTTTGTGTTTGGTTCTGTTTGCTTTCACAACTATCTTAGGCTGGTCCTATTATGGTGAGCGTTGTTTTGAGTTTTTATTTGGGGTTAAACACATCAATATTTATCGCTCTATTTTCATTATCATGGTCGCCTTAGGTGGTTTCTTAGAATTAGATCTTATCTGGACAATTGCCGATATCGTTAATGGGCTAATGGCTATACCAAATCTTATTGCCTTATTAGCCTTATCACCAATTATTATTGCAGAAACAAGAAATTATTTTAAACGTAAAAACAAGAGCTTCATTAAAACTAAAACAAGGTTAGGATAA","10.20","11.82","48320","MLTFFKALDSLVWGAPLLVLLVGTGIYLSTRLRLLQVLKLPLAFKLIFAEDKGEGDISSFAALATALAATVGTGNIVGVATAIKAGGPGALFWMWIAAFFGMATKYAEGLLAIKYRTKDANGEVSGGPMYYIINGMGKKWKPLAIFFALAGILVAFLGIGTFSQVNSITASLKNSFNWSPQIVSILIAIVVAVIIFGGIQSIAKVSEKLVPFMAAAYIIATLIVIFMHYNHIIPAIEQVFSGAFTGTAAVGGFAGVVVKEAIQNGIARGVFSNESGLGSAPIAAAAAKTHEPAEQGLISMTGTFIDTLVICTLTGLSILVTGKWTVKGLEGAPLTQSAFATVFGNIGVLVLTLCLVLFAFTTILGWSYYGERCFEFLFGVKHINIYRSIFIIMVALGGFLELDLIWTIADIVNGLMAIPNLIALLALSPIIIAETRNYFKRKNKSFIKTKTRLG","1117531","","sodium:alanine (or glycine) symporter","Membrane, Cytoplasm","Several matches in gapped BLAST to amino acid symporter: residues 1-439 are 62% similar to the protein in S.pyogenes (gi15675226). Residues 1-441 are 57% similar to the protein from S.pneumoniae (gi15900327).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1145 (1e-159).","

InterPro
IPR001463
Family

Sodium:alanine symporter
PR00175	$\"[86-108]T$ $\"[180-198]T$ $\"[208-227]T$ $\"[303-321]T$ $\"[348-370]T$ $\"[407-427]T$	NAALASMPORT
PF01235	$\"[40-441]T$	Na_Ala_symp
TIGR00835	$\"[13-438]T$	agcS
PS00873	$\"[86-101]T$	NA_ALANINE_SYMP

","BeTs to 6 clades of COG1115COG name: Sodium-alanine symportersFunctional Class: EThe phylogenetic pattern of COG1115 is ---k----eB-Huj---LIN-Number of proteins in this genome belonging to this COG is 1","***** IPB001463 (Sodium:alanine symporter family) with a combined E-value of 6.1e-118. IPB001463A 58-108 IPB001463B 182-229 IPB001463C 265-296 IPB001463D 357-369 IPB001463E 405-445 IPB001463D 356-368","Residues 3-319 are 46% similar to a (PROTEOME COMPLETE TRANSPORT SYMPORTER) protein domain (PD005953) which is seen in Y883_HAEIN.Residues 322-439 are 46% similar to a (PROTEOME COMPLETE TRANSPORT SYMPORTER) protein domain (PD170825) which is seen in Q9KS39_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 14 15:37:10 2002","Wed Sep 13 11:08:02 2006","Wed Sep 13 11:08:02 2006","Thu Feb 14 15:06:29 2002","Thu Feb 14 15:06:29 2002","Thu Feb 14 15:06:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1076 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 14 15:06:29 2002","","No significant hits to the NCBI PDB database.","SMU.1175","","Residues 40 to 451 (E-value = 3.5e-175) place SMu1076 in the Na_Ala_symp family which is described as Sodium:alanine symporter family (PF01235)","Thu Feb 14 15:06:29 2002","24379605","","","","","","1","","","SMU.1175","383" "SMu1077","1117621","1118811","1191","ATGTCAACACCCGCTGATAACCTTAAACTTGCTCGGCGTGGTCCAACAATCGCTATTTCTGTTTATTTGACTTTGGCACTTGCTAAACTGATTTCAGGGCATTTATTGCATTCTGCTTCACTAACAGCCGATGGCTTTAACAATGTTTCTGATATTGTGGCCAATGTCACCATTTTAATTGGACTTTATCTGGCCAGCAAGCCTGCTGATAAGGATCATAAATTTGGCCATTGGAAAATTGAAGACCTAGCCAGTTTAATCACTTCATTTATCATGTTTACTGTCGGTTTTCAGGTTCTGCTGGAAACGATTAACGGCATTATTCACAACAGTCGTGCCCAAATTGATCCTTATGGCGCTCTGGTTGGAATAATTTCTGCTATTGTTATGTTTATCCTCTACCTCTACAATAAACAGTTGTCGAAAAAATTAAAATCAGGCGCCCTGATGGCTGCAGCAAAAGACAATCTCTCTGATGCCCTGACTTCTCTAGGAACATCTATTGCCATACTTGCCAGTACCTTTAATCTCTTAATCATTGATAAAATGACTGCGGTTATCATTACTCTTCTTATTTTGAAAACAGCTTATGACATCTTTATGACCAGCGCTTTTAGTCTTTCTGATGGTTTTGATGATAAGCAGCTGCAAGAATACGAAAAAGCTATTTTAGAGATTCCTAAAATTTCTGCCGTAAAATCTCAACGCGGACGGACTTATGGTAGCAATGTTTATTTAGATTTGGTTTTAGAAATGAACCCTGATTTATCTGTCTATGAAAGTCATGCTATTACAGAAAGAGTCGAAAAGCTCTTACATGAGCAGTTTAATGTTTATGATATTGATATCCATGTCGAGCCAGCAGCTATCCCGGAAGATGAAATTTTTGAAAATGTCTATCATAAACTTTATAAATATGAGAAAATCATTTTAACTAAGACTTCAGACTATGAACAGCTCCTAACAGATTCTTTTATCTTAATTGATGAGAAAGGACATGTTAATGCAAAAGCAGCATTCCTAAAAGGTCGCTCAAGTGAAGCAAAACATTTTAACTCTTTTAAGATGCTTTCCATCAGCCAAAAGACTAAACTCATTACTTACGAATTAGATAGCTACCGACATACCAGTCTTTGGCGTCGGCATGAGAGATGGCAGATTATTTACCATCAAGTCTCGCCTATTCTTTAA","7.10","0.38","44524","MSTPADNLKLARRGPTIAISVYLTLALAKLISGHLLHSASLTADGFNNVSDIVANVTILIGLYLASKPADKDHKFGHWKIEDLASLITSFIMFTVGFQVLLETINGIIHNSRAQIDPYGALVGIISAIVMFILYLYNKQLSKKLKSGALMAAAKDNLSDALTSLGTSIAILASTFNLLIIDKMTAVIITLLILKTAYDIFMTSAFSLSDGFDDKQLQEYEKAILEIPKISAVKSQRGRTYGSNVYLDLVLEMNPDLSVYESHAITERVEKLLHEQFNVYDIDIHVEPAAIPEDEIFENVYHKLYKYEKIILTKTSDYEQLLTDSFILIDEKGHVNAKAAFLKGRSSEAKHFNSFKMLSISQKTKLITYELDSYRHTSLWRRHERWQIIYHQVSPIL","1118820","","cation efflux protein","Membrane, Cytoplasm","Several matches in gapped BLAST to cation efflux system protein: residues 4-395 are 63% similar to the protein in S.pyogenes (gi15675227).Residues 1-391 are 62% similar to the protein from S.pneumoniae (gi15901395).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1146 (1e-149).","

InterPro
IPR002524
Family

Cation efflux protein
PTHR11562	$\"[8-300]T$	Cation_efflux
PF01545	$\"[15-292]T$	Cation_efflux
TIGR01297	$\"[11-290]T$	CDF

","BeTs to 12 clades of COG0053COG name: Predicted Co/Zn/Cd cation transportersFunctional Class: PThe phylogenetic pattern of COG0053 is AmT-YqvceBr-----o---xNumber of proteins in this genome belonging to this COG is 1","***** IPB002524 (Cation efflux family) with a combined E-value of 6.4e-23. IPB002524A 25-65 IPB002524B 67-106 IPB002524A 133-173","Residues 136-393 are 42% similar to a (PROTEOME COMPLETE CATION TRANSPORTER) protein domain (PD401347) which is seen in Q9CIP8_LACLA.Residues 136-269 are 27% similar to a (PROTEOME COMPLETE TRANSMEMBRANE) protein domain (PD415459) which is seen in O53471_MYCTU.Residues 136-286 are 46% similar to a (COMPLETE PROTEOME CATION EFFLUX) protein domain (PD186977) which is seen in YEAB_BACSU.Residues 2-135 are 51% similar to a (COMPLETE PROTEOME TRANSMEMBRANE ZINC) protein domain (PD001602) which is seen in Q9CIP8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:31:42 2002","Wed Sep 13 11:12:51 2006","Wed Sep 13 11:12:51 2006","Thu Feb 14 15:54:28 2002","Thu Feb 14 15:54:28 2002","Thu Feb 14 15:54:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1077 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 14 15:54:28 2002","","No significant hits to the NCBI PDB database.","SMU.1176","","Residues 15 to 292 (E-value = 8.2e-90) place SMu1077 in the Cation_efflux family which is described as Cation efflux family (PF01545)","Thu Feb 14 15:54:28 2002","24379606","","","","","","1","","","SMU.1176","384" "SMu1078","1119767","1118934","834","ATGACATTCAAAAAAGCAGTAACAGCTCTTATTACTTTTCTAGCAGTAGTAACTTTGACAGCCTGTGGTAAAAAAGGAGCTGATTCCCAAGATAATTGGAAAAAATTTGAGTCGAAAAAATCTGTTACTATTGGTTTTGATAATACTTTTGTTCCCATGGGATTTAAAGACAAGAATGGTAAAAATGTTGGCTTTGATATTGACTTAGCAAATGCTGTCTTTAATGAATACGGTATCAAGGTGAAATGGCAGCCAATCAATTGGGATTTGAAGGAAACGGAGCTGAAAAATGGTAAAATTGATTTGATTTGGAATGGCTATTCCAAAACTAGGGAACGTGCACGCAAGGTATCCTTTACCAAGCCTTATATGAAAAATGACCAAGTTCTTGTCACGAAGAAGTCATCTGGTATTACGAGCTTTGCTGATATGAAAGGCAAAGCTTTAGGTGCTCAGTCAGGTTCATCTGGCTATGATGCTTTCACAGCTAATCCTAAAATTTTAAAAGATATTGTTAAAGATAATGATGCCAGTCAATATGAAACCTTTACCCAAGCCTTCATTGACTTAAAAAATGATCGTATTAATGGTCTTTTAATTGATCGTGTTTATGCCAATTATTACCTTAAGCAGGAAAAGGAACTTGATAACTATAATATTATCAAAGGAAAATATGCCAGTGAAGATTTTTCAGTTGGAGTGCGCAAATCTGATAAAACCTTGAAGAAGAAAGTCAATCAAGCTTTCAAAAAGCTTTACAAAAATGGTAAATTCCAAGCAATCTCCCAAAAATGGTTTGGTCAAGATGTTGCTTCAAATGCGATTAAGAGGTAA","10.50","19.95","31331","MTFKKAVTALITFLAVVTLTACGKKGADSQDNWKKFESKKSVTIGFDNTFVPMGFKDKNGKNVGFDIDLANAVFNEYGIKVKWQPINWDLKETELKNGKIDLIWNGYSKTRERARKVSFTKPYMKNDQVLVTKKSSGITSFADMKGKALGAQSGSSGYDAFTANPKILKDIVKDNDASQYETFTQAFIDLKNDRINGLLIDRVYANYYLKQEKELDNYNIIKGKYASEDFSVGVRKSDKTLKKKVNQAFKKLYKNGKFQAISQKWFGQDVASNAIKR","1118949","For other components see SMu1079 (NBD1) and SMu1080 (MSD1)For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762 (atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1036 (atmD); SMu1112 (atmA); SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).","amino acid ABC transporter, amino acid-binding protein","Extracellular, Periplasm, Membrane","Matches in gapped BLAST to amino acid ABC transporter, amino acid-binding protein:residues 11-267 are 28% similar to the previously published AtmA in S.mutans (gi|15625428|). Residues 1-277 are 71% similar to amino acid-binding protein Abp in S.uberis (gi|3603430|).Residues 4-276 are 62% similar to the protein from S.pneumoniae (gi|5929889|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0949 (6e-99).","

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[42-268]T$	SBP_bac_3
SM00062	$\"[41-269]T$	PBPb

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[39-164]T$	G3DSA:3.40.190.10
PS51257	$\"[1-22]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[3-273]T$	SSF53850

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[134-176]T$	ABC_transporter
PF00005	$\"[27-209]T$	ABC_tran
PS00211	$\"[134-148]T$	ABC_TRANSPORTER_1
PS50893	$\"[2-208]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-200]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-207]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-204]T$	PTHR19222
PTHR19222:SF33	$\"[2-204]T$	PTHR19222:SF33
SSF52540	$\"[1-207]T$	SSF52540

","BeTs to 7 clades of COG1126COG name: ABC-type polar amino acid transport system, ATPase componentFunctional Class: EThe phylogenetic pattern of COG1126 is a-----vcEB-Huj----inxNumber of proteins in this genome belonging to this COG is 7","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.6e-32. IPB001140A 16-62 IPB001140B 131-169","Residues 22-207 are 27% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 118-195 are 33% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 1-52 are 46% similar to a (TRANSPORT ATP-BINDING IRON CHELATIN) protein domain (PD351726) which is seen in Y888_HELPY.Residues 18-65 are 58% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in POTA_HAEIN.Residues 134-176 are 69% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in P74888_SALTY.Residues 77-132 are 46% similar to a (ATP-BINDING PROTEOME AMINO COMPLETE) protein domain (PD194799) which is seen in O84132_CHLTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:46:14 2007","Wed Oct 16 08:33:15 2002","Tue Apr 24 10:46:14 2007","Thu Feb 14 17:09:51 2002","Thu Feb 14 17:09:51 2002","Thu Feb 14 17:09:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1079 is paralogously related (blast p-value < 1e-3) to SMu0849, SMu0517, SMu0731, SMu0218, SMu1380, SMu0418, SMu0594, SMu1920, SMu1003, SMu0884, SMu0805, SMu1428, SMu1288, SMu0216, SMu1762, SMu0971, SMu0390, SMu0786, SMu1210, SMu1246, SMu1231, SMu1068, SMu0235, SMu1949, SMu1518, SMu1751, SMu0335, SMu1517, SMu1023, SMu0916, SMu1950, SMu0596, SMu1036, SMu1001, SMu0234, SMu1093, SMu0374, SMu1649, SMu1757, SMu1037, SMu0825, SMu1064, SMu0950, SMu1065, SMu0258, SMu1316, SMu0976, SMu0907, SMu0164, SMu0024, SMu1410, SMu0944, SMu1710, SMu0986, SMu0476, SMu1306, SMu0475, SMu0224, SMu1959, SMu1545, SMu0837, SMu1724, SMu0836, SMu0752, SMu0987, SMu0823, SMu1811, SMu1050, SMu0729, SMu0824, SMu0666, SMu1202, and SMu1686, all with ATP binding capabilities.","Thu Feb 14 17:10:26 2002","Tue Apr 24 10:46:14 2007","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 146 3e-036pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 146 3e-036","SMU.1178c","","Residues 27 to 209 (E-value = 1.3e-59) place SMu1079 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Feb 14 17:09:51 2002","24379608","","Russell,R.R.B., Aduse-Opuko,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267, 4631-4637 (1992)PubMed: 1537846Russell RR, Ferretti JJNucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans.J Gen Microbiol 1990 May;136 ( Pt 5):803-10PubMed: 2380687PMID: 2380687Aduse-Opoku J, Tao L, Ferretti JJ, Russell RRBiochemical and genetic analysis of Streptococcus mutans alpha-galactosidase.J Gen Microbiol 1991 Apr;137 ( Pt 4):757-64PubMed: 1649890 PMID: 1649890Ferretti JJ, Huang TT, Russell RRSequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.Infect Immun 1988 Jun;56(6):1585-8PubMed: 2967248PMID: 2967248Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:46:14 2007","","1","","","SMU.1178c","552" "SMu1080","1121068","1120427","642","ATGTCTTATATATCAGAAGTTTTACCGAGTCTTTTAGATGGGGCGCTGATTACTTTACAAGTCTTTTTTATTGTTATTCTCTTTTCAATTCCTTTAGGAGCTATATTAGCTTTCCTTATGCAGGTACCTTTTAGACCTTTACGTTGGCTGTTAAATCTCTATGTTTGGATTATGCGTGGGACACCGCTCCTTTTACAACTGATTTTTATTTATTATGTTTTGCCAAGTGCAGGGATCACTTTTGATCGTATGCCAGCAGCTATTTTAGCTTTTACTCTCAACTATGCTGCCTATTTTGCGGAAATCTTCCGCGGCGGTATTGAGGCTATTCCTAAAGGGCAATATGAAGCTGCTAAGGTTCTTAAATTAAGTCAGATACAGACTGTTCGCTATATTATTTTGCCTCAGGTTGTCAAGATTGTTTTACCGAGTGTCTTTAATGAAATCATCAATCTTGTTAAAGATTCTTCTCTAGTCTATGTACTTGGTGTTGGTGATTTGCTTTTAGCCAGTAAGACAGCGGCCAATCGTGACGCTACATTAGCACCAATGTTTATTGCCGGCGGTATTTATTTGATTTTAATTGGTGTTGTTACCATTTTATCAAAATACGTTGAGAAAAAATTTAGTTATTATAAGTAA","10.30","5.99","23776","MSYISEVLPSLLDGALITLQVFFIVILFSIPLGAILAFLMQVPFRPLRWLLNLYVWIMRGTPLLLQLIFIYYVLPSAGITFDRMPAAILAFTLNYAAYFAEIFRGGIEAIPKGQYEAAKVLKLSQIQTVRYIILPQVVKIVLPSVFNEIINLVKDSSLVYVLGVGDLLLASKTAANRDATLAPMFIAGGIYLILIGVVTILSKYVEKKFSYYK","1120442","For other components see SMu1079 (NBD1) and SMu1078 (SBP1)For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0329 (glnA);SMu0741 (glnH);SMu1509 (glnB); SMu1380 (glnQ);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP).","amino acid ABC transporter, permease","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to amino acid ABC transporter (permease protein):residues 1-213 are 80% similar to the protein in S.pyogenes (gi15675231) and are 69% similar to the proteinin S.pyogenes (gi15903398) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0947 (3e-89).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[11-211]T$	BPD_transp_1
PS50928	$\"[15-202]T$	ABC_TM1

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[7-105]T$	HEQRo_perm_3TM

InterPro
IPR004624
Family

PhnA protein
TIGR00686	$\"[2-110]T$	phnA

InterPro
IPR013987
Domain

PhnA protein, N-terminal
PF08274	$\"[2-31]T$	PhnA_Zn_Ribbon

InterPro
IPR013988
Domain

PhnA protein, C-terminal
PF03831	$\"[42-96]T$	PhnA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-34 are 72% similar to a (PROTEOME COMPLETE UPTAKE ALKYLPHOSPHONATE) protein domain (PD015624) which is seen in Q9I704_PSEAE.Residues 42-109 are 80% similar to a (PROTEOME COMPLETE UPTAKE ALKYLPHOSPHONATE) protein domain (PD229332) which is seen in PHNA_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 19 10:01:22 2002","Mon Jul 10 14:20:45 2006","Mon Jul 10 14:20:45 2006","Tue Feb 19 09:58:02 2002","","Tue Feb 19 09:58:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1081 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 19 09:58:02 2002","","No significant hits to the NCBI PDB database.","SMU.1180c","","Residues 42 to 96 (E-value = 2.2e-35) place SMu1081 in the PhnA family which is described as PhnA protein (PF03831)","Tue Feb 19 09:58:02 2002","","","","Kulakova AN, Kulakov LA, Akulenko NV, Ksenzenko VN, Hamilton JT, Quinn JP.Structural and functional analysis of the phosphonoacetate hydrolase (phnA) gene region in Pseudomonas fluorescens 23F.J Bacteriol. 2001 Jun;183(11):3268-75.PMID: 11344133 ","","Tue Feb 19 10:05:15 2002","1","","","SMU.1180c","797" "SMu1082","1122914","1121766","1149","ATGAAAAAAGCAGTACATTTTGGAGCAGGCAATATTGGCCGTGGTTTTATTGGACAAATTTTATTTGAAAATGGCTTTGCTATTGATTTTGTCGATGTTAACGATAAAATTATTAATGCTCTTAATGAACGTCATTCTTATGATATTGAAATTGCAGAAGATGGGAAACGTCACATTACAGTTTCTAATGTTGCTGGCATTAATAACAAGGAAAATCCTCAAGCAGTCATTGATGCTGTGGCTGAAACAGAGTTGATTACAACCGCTATTGGCCCTAACATTTTGCCTTTTATTGCCCAATTAATTGCCAAAGGTATTGAAAAACGCCGTGAAAGTCAGAATCAAACGCCACTGGATATCATTGCCTGTGAAAATATGATTGGTGGCTCTGCCTTTCTCTGGCAGGAAGTGCAGAAATACCTCAGCGCTGATGGTTTAGCTTTTGCTAAAGATTATATTGGCTTTCCAAATGCTGCTGTTGACCGTATTGTTCCAGCTCAGGTTCATGAAGATCCCCTCTTTGTTGTGGTTGAGCCATTTTCAGAATGGGTAGTCGAAACTGCTGCTATGAAAAATCCTGATTTAAAATTGTCTTCAGTTCACTATGAAGAAAATTTGGAACCATTCATTGAAAGAAAGCTTTTCTCTGTTAATTCAGGTCATGCAACAACAGCTTATACAGGTGCTTATTTTGGTGCTAAGACGGTCCTAGAAGCACTTAAAGACCAACAAGTTAAAGAGCAAGTAAAGGCAGTTTTAGGTGAAATTCGCCAGCTTTTAATGGCTAAATGGCAATTCAAAGAGAATGATCTGAAAGTTTATCATGATATTATTATCAGTCGTTTTGAAAATCCTTATATTGTAGATGATGTTACTCGTGTTGCCAGAACACCAATTCGTAAGTTAGGTTATGATGAACGCTTTATCCGTCCCATTCGTGAGCTGAAAGATCGTGGTTTATCTTATGAATATCTTTTGCAAACAGTGGCTTATGTTTTCCATTACAAGGATTCAAATGATGAACAAAGTGTTCAACTTAAACTGCTTCTACAAGAAAAGTCTTTAAAAGCAGTTGTTAAAGAAGTAACAGGATTGACAGATGCCGCTTTGATTGAAGAAATTGTTACCAGTGTTGAATCTTTAGATTAA","5.00","-12.08","42959","MKKAVHFGAGNIGRGFIGQILFENGFAIDFVDVNDKIINALNERHSYDIEIAEDGKRHITVSNVAGINNKENPQAVIDAVAETELITTAIGPNILPFIAQLIAKGIEKRRESQNQTPLDIIACENMIGGSAFLWQEVQKYLSADGLAFAKDYIGFPNAAVDRIVPAQVHEDPLFVVVEPFSEWVVETAAMKNPDLKLSSVHYEENLEPFIERKLFSVNSGHATTAYTGAYFGAKTVLEALKDQQVKEQVKAVLGEIRQLLMAKWQFKENDLKVYHDIIISRFENPYIVDDVTRVARTPIRKLGYDERFIRPIRELKDRGLSYEYLLQTVAYVFHYKDSNDEQSVQLKLLLQEKSLKAVVKEVTGLTDAALIEEIVTSVESLD","1121781","For other 'mtl' genes see SMu1083 (mtlA2);SMu1084 (mtlR) and SMu1085 (mtlA). ","mannitol 1-phosphate 5-dehydrogenase","Cytoplasm","Matches in gapped BLAST to mannitol-1-phosphate 5-dehydrogenase:residues 1-382 are 91% similar to the previously published enzyme in S.mutans (gi|400286|). Residues 1-375 are 64% similar to mannitol-1-phosphate 5-dehydrogenase in S.pneumoniae (gi|15902403|).Residues 1-374 are 57% similar to the enzyme from Lactococcus lactis subsp. lactis (gi|15672006|).SMu1082 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000669
Domain

Mannitol dehydrogenase, core
PR00084	$\"[4-14]T$ $\"[117-130]T$ $\"[153-166]T$ $\"[171-186]T$	MTLDHDRGNASE
PS00974	$\"[153-165]T$	MANNITOL_DHGENASE

InterPro
IPR008927
Domain

6-phosphogluconate dehydrogenase, C-terminal-like
SSF48179	$\"[205-381]T$	6DGDH_C_like

InterPro
IPR013118
Domain

Mannitol dehydrogenase, C-terminal
PF08125	$\"[151-374]T$	Mannitol_dh_C

InterPro
IPR013131
Domain

Mannitol dehydrogenase rossman, N-terminal
PF01232	$\"[2-126]T$	Mannitol_dh

InterPro
IPR013328
Domain

Dehydrogenase, multihelical
G3DSA:1.10.1040.10	$\"[204-348]T$	Opine_DH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[5-203]T$	G3DSA:3.40.50.720
SSF51735	$\"[3-204]T$	SSF51735

","BeTs to 5 clades of COG0246COG name: Mannitol-1-phosphate/altronate dehydrogenasesFunctional Class: GThe phylogenetic pattern of COG0246 is ----Y-v-EB-----p-----Number of proteins in this genome belonging to this COG is 1","***** IPB000669 (Mannitol dehydrogenase) with a combined E-value of 4.6e-70. IPB000669A 5-16 IPB000669B 153-165 IPB000669C 171-192 IPB000669D 199-242 IPB000669E 274-302","Residues 239-336 are identical to a (MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE NAD) protein domain (PD009207) which is seen in MTLD_STRMU.Residues 337-382 are 65% similar to a (5-DEHYDROGENASE MANNITOL-1-PHOSPHATE NAD) protein domain (PD068531) which is seen in MTLD_STRMU.Residues 3-238 are 93% similar to a (OXIDOREDUCTASE NAD MANNITOL-1-PHOSPHATE) protein domain (PD004131) which is seen in MTLD_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:47:12 2002","Tue Feb 19 10:09:35 2002","Wed Oct 16 08:47:12 2002","Tue Feb 19 10:09:11 2002","Tue Feb 19 10:09:11 2002","Tue Feb 19 10:09:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1082 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 19 10:09:35 2002","","No significant hits to the NCBI PDB database.","SMU.1182c","","Residues 2 to 360 (E-value = 4.8e-191) place SMu1082 in the Mannitol_dh family which is described as Mannitol dehydrogenase (PF01232)","Tue Feb 19 10:09:11 2002","","","Honeyman,A.L. and Curtiss,R. III.Isolation, characterization, and nucleotide sequence of theStreptococcus mutans mannitol-phosphate dehydrogenase gene and themannitol-specific factor III gene of the phosphoenolpyruvatephosphotransferase systemInfect. Immun. 60 (8), 3369-3375 (1992)PubMed: 1322373","Fischer,R., von Strandmann,R.P. and Hengstenberg,W.Mannitol-specific phosphoenolpyruvate-dependent phosphotransferasesystem of Enterococcus faecalis: molecular cloning and nucleotidesequences of the enzyme IIIMtl gene and the mannitol-1-phosphatedehydrogenase gene, expression in Escherichia coli, and comparisonof the gene products with similar enzymesJ. Bacteriol. 173 (12), 3709-3715 (1991)PubMed: 1904856","Tue Feb 19 10:10:35 2002","Tue Feb 19 10:13:04 2002","1","","","SMU.1182c","" "SMu1083","1123367","1122930","438","ATGGAATTTCAAAAAGATTTAATTAAATTGAACCAACATTTTCCCGATAAGGAAGCTGCTATTCGTTTTTGTGGACAGCTCTTAGCTGATGGTGGTTACGTAGAACCAGCTTATATTGACGCCATGATTCAGCGCGATAAAGAACTCTCTGTTTATATGGGAAATTTCATTGCCATTCCTCATGGAACGGACGACGCTAAAAAGGATGTTCTCAAATCAGGTATCACAGTTGTTCAGGTACCAGACGGTGTTAATTTTGGAACAGAAGACGATCCGCAAGTTGCGACAGTTTTATTTGGCATCGCTGGAATTGGTGATGAACATTTGCAAATCATTCAAAATATTTCGATTTTCTGTGCAGATGTTGATAATGTTGTTAAGTTAGCTGATGCTCAAACAGAAGATGAGGTTGTCAAACTTTTAAGTCAAGTCAATTAA","4.20","-12.38","15862","MEFQKDLIKLNQHFPDKEAAIRFCGQLLADGGYVEPAYIDAMIQRDKELSVYMGNFIAIPHGTDDAKKDVLKSGITVVQVPDGVNFGTEDDPQVATVLFGIAGIGDEHLQIIQNISIFCADVDNVVKLADAQTEDEVVKLLSQVN","1122945","For other 'mtl' genes see SMu1082 (mtlD);SMu1084 (mtlR) and SMu1085 (mtlA). ","phosphotransferase system enzyme II","Cytoplasm","This sequence corresponds to the previously published gi|282316, gi|153745, gi|400897 in GenBank. Also there are similarities to this protein in other bacteria, e.g. residues 1-139 are 71% similar to gi|15672005 from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1346 (1e-05).","

InterPro
IPR002178
Domain

Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PD001689	$\"[8-136]T$	PTS_EIIA_2
G3DSA:3.40.930.10	$\"[3-141]T$	PTS_EIIA_2
PF00359	$\"[1-144]T$	PTS_EIIA_2
PS00372	$\"[46-62]T$	PTS_EIIA_TYPE_2_HIS
PS51094	$\"[1-144]T$	PTS_EIIA_TYPE_2

noIPR
unintegrated

unintegrated
SSF55804	$\"[1-143]T$	SSF55804

","BeTs to 6 clades of COG1762COG name: Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)Functional Class: G,TThe phylogenetic pattern of COG1762 is --------EB-H--gPOLIN-Number of proteins in this genome belonging to this COG is 4","***** IPB002178 (phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2) with a combined E-value of 5.9e-07. IPB002178 45-62","Residues 118-145 are identical to a (COMPONENT IIA SYSTEM PHOSPHOTRANSFERASE) protein domain (PD222309) which is seen in PTMA_STRMU.Residues 6-117 are identical to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIA) protein domain (PD001689) which is seen in PTMA_STRMU.Residues 1-145 are 25% similar to a (COMPONENT IIA SYSTEM PHOSPHOTRANSFERASE) protein domain (PD397868) which is seen in PTMA_MYCPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:48:12 2002","Fri Jan 11 13:06:44 2002","Wed Oct 16 08:48:12 2002","Tue Feb 19 10:14:16 2002","Fri Jan 11 13:06:44 2002","Fri Jan 11 13:06:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1083 is paralogously related (blast p-value < 1e-3) to SMu0103, a predicted PTS system, fructose-specific IIA component.","Fri Jan 11 13:10:27 2002","Fri Jan 11 13:06:44 2002","pdb|1A3A|C Chain C, Crystal Structure Of Iia Mannitol From Esch... 116 1e-027","SMU.1183c","","Residues 1 to 144 (E-value = 1.3e-81) place SMu1083 in the PTS_EIIA_2 family which is described as Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PF00359)","Fri Jan 11 13:06:44 2002","","","Honeyman,A.L. and Curtiss,R. III.Isolation, characterization, and nucleotide sequence of theStreptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvatephosphotransferase systemInfect. Immun. 60 (8), 3369-3375 (1992)PubMed: 1322373 ","Koning RI, Keegstra W, Oostergetel GT, Schuurman-Wolters G, Robillard GT, Brisson A.The 5 A projection structure of the transmembrane domain of the mannitol transporter enzyme II.J Mol Biol. 1999 Apr 16;287(5):845-51.PMID: 10222194","Tue Apr 2 17:52:51 2002","Fri Jan 11 13:06:44 2002","1","","","SMU.1183c","" "SMu1084","1125321","1123369","1953","ATGCTATTAACAAAGAGAGAAAAACACTTATTAGCAGCTTTCCAAAATTATGGGAAGCTGTCGCTTAAACAGATGATAGATTTGCTTAAGGTATCTCAGAGAACCGTTTATCGGACAATTTCTGATTTAACAGATAGCCTTAACACGATTAATATTAGCATCATCAAAGAAAATCAAAACTATTTTCTCGTAGGAGAATTAGCTAATCTGGCTAGTATTATTAGTCTAGATACTTATGAACAGTATGAACGTTTGAATCTCATTACCTATAAGTTATTGATGAGTTTTAGCAGTATCACAAATGAGCAGCTGCAGGAGGAATTTAATGTTTCTAATGTTACCATTATTCAAGATATTGCTGAAATTGAAAAGCGTTTGGCAGATTTTGACTTACGGTTAGATCGTAAAAAAGGTTACCGTTTAGTAGGAAATAAAAACACTTTACGACGTTTATTGGCTATTTTATTAACTAATAACCTTTCGATTTCTGATTTTGGGGCAGGAGCATATGGTCATTTTGAAGTCTTAGACAAGGCAAAATTAGAACTTGCGAAACAAATCTTTCAATCATCACAAGAAGATCTACCTGATTTAGATGCTAAGATGAGTGAGTTTTTCATCATTCTCTTAGCCTTATCAGGTTGGCGGGACAATGAAGCAGTTGGACACAGTATTAGCAAAGCAGCTCTTGATTTTTCACAGAAAGTTTATACTGAATTTTCACAGAAAACCAATCAATTTTACAGTATTCAAGAGATTCTTTATTATGCCAGTATTTTAGATGAACTGGTTATTAAGAGACAGGAAACGCCGCTTTTTCATGAAAAATTTGACAGTGCTTTTTTCTATAATATTTCAAATTTGATTGATAAAGTATCTCTTTATACTAAAATTAATTTTGCTAAGGATAAAACACTCTTTCATTTTCTGTTTAATCATATTCGCTTGAATTTGGCTGTCCCTCAAATTTTTGAAGACAAGTCAAATAATACGATTGCTCATGAGGTTGTTCAAGGCAATGAATATCTACATCGTGTTGTTAGTCTTCTGGTTCAGGATATTTTTCCGAAGTATTTGCAAAAGGAACCAGAGTATGAATTAATTACCTTACATTTTGCTTCAAGTCTGCGCCGCAGTCCAGATATTTATCCTATTAAGATTTTACTTTTAACAGATGAGCGTCCCTTAGCGAGAGAACTTCTCATCACACGTATTAAAACCATTGCACCTTTTGTTGATAAGGTAGTTGTCAAAGAATTGGCTCAGTATGAAACAAAGGATAAAGATTATTATAATTGTGTCTTGGCAACCAAGCCTTTAGTGGATAAGGCAGTCAAAATGGTTTCTACTTATCCTGATGCAAAAGAAATGCTGCAACTTCAAGATTATTTACAGAATGTACAGGCTCATCAAAAAATCATCATTCGCGATGAGCAGACAAATAAGCAAGGTTATAATCTTCAAAATTATTTTTTGGCTACACAACAACTTTTACAGGAATTTTCTTATCAAGAGATTGATAATCCTGCTGATTTTGAAACAAGTGTTCCAAAAATTATGGAGACTATTGCTGCAGTTTCAGATAAAACTTATCTGTCCAGTAAGTTATTAAAATGTTTTGCTGTCAGTCCCTTGGCTATTCCAGAGACTCATTTGGCTCTTTTGCATACACAGTCAAGTAAGGTTATAACGTCTTGTTTTAAAATTTATGATTTAAAAAGACCTGTAACAGCTCTGTCCATGAATTACGAAAAAGAGACAGTTACAAGAATTTTGGTTATGCTGACACGGTTAGATGAAACAAAAGAAATGAGAGATTTAATGACGGCCATCAGTCAATCTATCATCGAAAATCATCTTTATACAGAAATTTACAAGACAGGTAATAAAGATATTATTTATCAATTATTGAATCAAATATTTACAGAAAAAATAAAGAAATTGGAGACCTAA","6.70","-1.95","75330","MLLTKREKHLLAAFQNYGKLSLKQMIDLLKVSQRTVYRTISDLTDSLNTINISIIKENQNYFLVGELANLASIISLDTYEQYERLNLITYKLLMSFSSITNEQLQEEFNVSNVTIIQDIAEIEKRLADFDLRLDRKKGYRLVGNKNTLRRLLAILLTNNLSISDFGAGAYGHFEVLDKAKLELAKQIFQSSQEDLPDLDAKMSEFFIILLALSGWRDNEAVGHSISKAALDFSQKVYTEFSQKTNQFYSIQEILYYASILDELVIKRQETPLFHEKFDSAFFYNISNLIDKVSLYTKINFAKDKTLFHFLFNHIRLNLAVPQIFEDKSNNTIAHEVVQGNEYLHRVVSLLVQDIFPKYLQKEPEYELITLHFASSLRRSPDIYPIKILLLTDERPLARELLITRIKTIAPFVDKVVVKELAQYETKDKDYYNCVLATKPLVDKAVKMVSTYPDAKEMLQLQDYLQNVQAHQKIIIRDEQTNKQGYNLQNYFLATQQLLQEFSYQEIDNPADFETSVPKIMETIAAVSDKTYLSSKLLKCFAVSPLAIPETHLALLHTQSSKVITSCFKIYDLKRPVTALSMNYEKETVTRILVMLTRLDETKEMRDLMTAISQSIIENHLYTEIYKTGNKDIIYQLLNQIFTEKIKKLET","1123384","For other 'mtl' genes see SMu1083 (mtlA2);SMu1082 (mtlD) and SMu1085 (mtlA). ","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulator:residues 1-650 are 98% similar to the previously published enzyme in S.mutans (gi|9622945|). Residues 1-649 are 53% similar to transcriptional regulator in S.pneumoniae (gi|15900315|).Residues 1-646 are 29% similar to the protein from Lactococcus lactis subsp. lactis (gi|15672004|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1801 (5e-09).","

InterPro
IPR002178
Domain

Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PS51094	$\"[490-640]T$	PTS_EIIA_TYPE_2

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[6-62]T$ $\"[84-140]T$	HTH_11

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-66]T$ $\"[77-144]T$	SSF46785
SSF55804	$\"[492-641]T$	SSF55804
SSF63520	$\"[251-380]T$	SSF63520

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-330 are 31% similar to a (PROTEOME TRANSCRIPTIONAL LYSR COMPLETE) protein domain (PD401622) which is seen in Q9CJH3_LACLA.Residues 3-314 are 21% similar to a (REGULATOR DEOR) protein domain (PD321515) which is seen in Q9F8B7_STRAG.Residues 496-640 are 33% similar to a (TRANSCRIPTIONAL PROTEOME REGULATOR) protein domain (PD357610) which is seen in Q9CJH3_LACLA.Residues 79-165 are 34% similar to a (TRANSCRIPTIONAL PROTEOME COMPLETE) protein domain (PD338858) which is seen in P96574_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:49:05 2002","Tue Feb 19 10:18:28 2002","Wed Oct 16 08:49:05 2002","Tue Feb 19 10:18:28 2002","","Tue Feb 19 10:18:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1084 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 19 10:18:28 2002","","No significant hits to the NCBI PDB database.","SMU.1184c","","No significant hits to the Pfam 11.0 database","Tue Feb 19 10:18:28 2002","24379613","","Honeyman,A.L. and Curtiss,R. III.Isolation, characterization, and nucleotide sequence of theStreptococcus mutans mannitol-phosphate dehydrogenase gene and themannitol-specific factor III gene of the phosphoenolpyruvatephosphotransferase systemInfect. Immun. 60 (8), 3369-3375 (1992)PubMed: 1322373","","Tue Feb 19 10:21:49 2002","","1","","","SMU.1184c","" "SMu1085","1127060","1125351","1710","ATGGTTATGCCTAATATTGGTGCCTTTATTGCATGGGGGGTTGCAGCATCTCTGTTTATTGCAACAGGTTACTTACCCAATAAAGCTTTAGATACCAATGTTGTTGGACCAATGTTGAAGTATGTGTTACCTCTTTTAATTGGTTACACTGGTGGTTACAATATTCACAAACAGCGTGGTGGCGTTATCGGTGCTATTGCTTCCTTTGGTGCCATTGCAGGTTCTACAGTAACCATGTTCATTGGTGCTATGATTATGGGGCCATTATCGGCTTGGATTTTAAAGAAATTCGATGAAAAAGTTCAGCCAAAAATCAGAACTGGTTTTGAAATGTTGGTAAACAACTTTTCACTTGGTTTGATTGGTTTTGCTTTGATGGTCTTGGCTTTCTTTGTTATTGGACCAGTTGTGGCTCAGTTAACAGAATGGGTTGGTATTGGTGTAGAAGCGATTGTTAAAGTTCACCTTTTGCCTTTAGCAAACTTAATTATTGAACCAGCTAAGATTCTCTTCTTAAATAACGCTCTTAACCATGGTATCTTTACGCCATTAGGTACAGAGCAAGTGGCTAAAGTTGGTAAATCTGTTCTCTTCCTATTGGAAGCTAATCCTGGACCTGGTCTTGGTGTGCTGATTGCTTATGCTATGTTTGGCAAAGGTTCTGCTAAATCTTCATCTTGGGGTGCTATGATTATCCATTTCTTTGGTGGTATTCATGAAATCTATTTCCCATATGTTATGATGAAACCGGCTATGTTCCTTGCTGTTATTGCTGGTGGTTTGACTGGTACCTTTACTTTCCAAACACTGGGTGCAGGTTTGACAGCACCCGCTTCACCGGGTTCAATTATCGCTATCATGGGAATGTCTCCTAAAGGTTGGGGACCTCACTTAGTTGTTCTTGCTGGTGTCTTTGCAGCAGCAGTGGCTTCCTTCCTAGTCGCTTCCATTATCTTGAAATCTGATAATTCAGATGATGATTCTCTGGAAACTGCACAAGCAGTGACACAAGCAGCAAAGGCCGAGTCTAAAGGTCAAGCAGTTACTGAACCAAACCTCCATTCAGATATTACAACAGACAATATTCATCAAATTATCTTTGCTTGTGATGCTGGTATGGGAAGTTCAGCCATGGGCGCTTCCATCCTTCGAGATAAAGTGAAAAAGGCTGGTCTTGATATTTCTGTGAGTAACCAAGCTATTTCCAATCTGCAGGATACAGCTAATACTTTAATTGTGACTCAAGAAGAGCTGGCAGATCGCGCGGGACAAAAAACCCCACGAGCTGTTCATGTAGCGGTAGATAATTTCTTAGCTACTTCTAAGTATGATGATATTATTGCTAGTTTAACAAATGGCAAAGCTAGTGGTAGTGAAAATGCAGCGCATTCAACACAAGCAGATAGTGCAGAAATTGATCTTAACCAAATTGATGCGGTCGTTTTTGCTTATGGTATCGCTAAAGGTTCAGCAACGATGGGACAAGAAACCCTGCGTTCAATCTTTAAACAGAATAATGTTAAAATCCCTGTTTCAACTGCTTCTTATGCTCATTTAAGTGACTACAATGCTAAAAATATTCTACTTGTCACAACAATTGCTCAGCAAGGGCAGGCACAGCAAGCGGCTCCTAATGCACAAATACTTGTTGTGGATAGCCTTGTGACAACACCAGAGTATGATAAGTTAGTCGCCAGAATGCATAAGTAA","7.20","0.85","59783","MVMPNIGAFIAWGVAASLFIATGYLPNKALDTNVVGPMLKYVLPLLIGYTGGYNIHKQRGGVIGAIASFGAIAGSTVTMFIGAMIMGPLSAWILKKFDEKVQPKIRTGFEMLVNNFSLGLIGFALMVLAFFVIGPVVAQLTEWVGIGVEAIVKVHLLPLANLIIEPAKILFLNNALNHGIFTPLGTEQVAKVGKSVLFLLEANPGPGLGVLIAYAMFGKGSAKSSSWGAMIIHFFGGIHEIYFPYVMMKPAMFLAVIAGGLTGTFTFQTLGAGLTAPASPGSIIAIMGMSPKGWGPHLVVLAGVFAAAVASFLVASIILKSDNSDDDSLETAQAVTQAAKAESKGQAVTEPNLHSDITTDNIHQIIFACDAGMGSSAMGASILRDKVKKAGLDISVSNQAISNLQDTANTLIVTQEELADRAGQKTPRAVHVAVDNFLATSKYDDIIASLTNGKASGSENAAHSTQADSAEIDLNQIDAVVFAYGIAKGSATMGQETLRSIFKQNNVKIPVSTASYAHLSDYNAKNILLVTTIAQQGQAQQAAPNAQILVVDSLVTTPEYDKLVARMHK","1125366","For other 'mtl' genes see SMu1083 (mtlA2);SMu1082 (mtlD) and SMu1084 (mtlR). From Genbank:[gi:1709899]This is a component of the phosphenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system. the IICD domains contain the sugar binding site and the transmembrane channel; the IIA domain contains the primary phosphorylation site (the donor is phospho-HPR);IIA transfers its phosphoryl group to the IIB domain which finally transfers it to the sugar.","mannitol PTS EII","Membrane, Cytoplasm","Matches in gapped BLAST to mannitol PTS EII:residues 1-569 are 86% similar to the previously published enzyme in S.mutans (gi|9622944|). Residues 1-569 are 60% similar to mannitol PTS EII in S.pneumoniae (gi|15902400|) SMu1085 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[1-260]T$	PTS_EIIC

InterPro
IPR003501
Domain

Phosphotransferase system, lactose/cellobiose-specific IIB subunit
PF02302	$\"[364-451]T$	PTS_IIB

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[88-241]T$	no description

InterPro
IPR013011
Domain

Phosphotransferase system, EIIB component, type 2
PS51099	$\"[363-458]T$	PTS_EIIB_TYPE_2

InterPro
IPR013014
Domain

Phosphotransferase system, EIIC component, type 2
PS51104	$\"[1-327]T$	PTS_EIIC_TYPE_2

InterPro
IPR013166
Domain

Citrate lyase ligase, C-terminal
SM00764	$\"[447-517]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10370	$\"[350-456]T$ $\"[465-569]T$	no description
signalp	$\"[1-16]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[60-94]?$ $\"[118-138]?$ $\"[144-164]?$ $\"[226-246]?$ $\"[252-274]?$ $\"[295-315]?$	transmembrane_regions

","BeTs to 3 clades of COG2213COG name: Phosphotransferase system, mannitol-specific IIBC componentFunctional Class: CThe phylogenetic pattern of COG2213 is --------Eb-----p-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 455-569 are 30% similar to a (MANNITOL EII PTS) protein domain (PD290733) which is seen in Q9KJ75_STRMU.Residues 1-77 are 80% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD010040) which is seen in Q9KJ75_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:49:51 2002","Mon Feb 25 08:42:20 2002","Wed Oct 16 08:49:51 2002","Mon Feb 25 08:42:20 2002","","Mon Feb 25 08:42:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1085 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 08:49:37 2002","","No significant hits to the NCBI PDB database.","SMU.1185c","","Residues 1 to 260 (E-value = 1.4e-11) place SMu1085 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)Residues 364 to 451 (E-value = 8.9e-12) place SMu1085 in the PTS_IIB family which is described as PTS system, Lactose/Cellobiose specific IIB subunit (PF02302)","Mon Feb 25 08:42:20 2002","","","","Henstra,S.A., Tolner,B., ten Hoeve Duurkens,R.H., Konings,W.N. and Robillard,G.T.Cloning, expression, and isolation of the mannitol transportprotein from the thermophilic bacterium Bacillus stearothermophilusJ. Bacteriol. 178 (19), 5586-5591 (1996)PubMed: 8824601","Mon Feb 25 08:49:37 2002","Mon Feb 25 08:49:37 2002","1","","","SMU.1185c","" "SMu1086","1129422","1127608","1815","ATGTGTGGTATTGTAGGTGTTGTCGGCAATCGTAATGCAACCGATATCCTAATGCAAGGATTGGAAAAATTGGAATATAGAGGTTATGATTCAGCAGGAATATATGTTATTAATCAACCTGAAAATGGACGTTTAATTAAATCAGTAGGACGAATTGCTGATTTGCGAGCTAAGATTGGTATCGATGTTGCTGGTTCTACAGGGATTGGTCATACACGTTGGGCAACCCATGGGCAAGCGACGGAGGAAAATGCTCATCCACATGCATCGGCTACAGGTCGTCTTGTCTTGGTTCACAATGGTGTCATTGAAAATTATCTCCAAATTAAAGAAAATTATTTGGCAGGACATAACTTGAAAGGTGAAACAGACACAGAAATTGCAGTTCATTTGATCGGTCAATTTGTGACAGATGGTTTGTCTGTACTTGAATCTTTCAAGAAGGCCTTGCATATCATTGAAGGTTCTTATGCCTTTGCTTTAATTGATTCGCAAAATCCAGATATTATTTATGTGGCTAAAAATAAATCACCACTTCTAATCGGTCTAGGTGAAGGCTATAATATGGTTTGTTCAGATGCTATGGCTATGATTCGTGAAACCAATCAATTTATGGAAATTCATGATAAAGAACTTGTTGTTTTAACAAAAGATACGGCTCAAGTATCAGATTATGATGGCAATCCTGTTGAACGTCAAGCATATACAGCAGAACTTGATTTATCAGATATTGGTAAAGGAACCTATCCTTACTACATGCTTAAAGAAATTGATGAACAGCCAACAGTTATGCGTAAATTGATTTCAACTTATGCTAATGAAAATGGTAAGTTAACAGTTGATCCTGCTATTGTGAAATCTGTTCAAGAAGCTGATCGCATCTATATTTTAGCTGCTGGAACATCTTATAATGCCGGTTTTGCCTCAAAATCAATGATTGAGACCTTGACCGATACGCCTGTTGAATTAGGGATTGCATCGGAATGGGGCTATAACATGCCATTATTGAGTAAAAAGCCAATGTTCATCTTGTTAAGTCAGTCTGGAGAAACAGCTGATAGTCGTCAGGTCTTGGTTAAGGCTAATGCCATGGGAGTTCCAAGTTTGACAATCACAAATGTTCCTGGATCAACCTTGTCACGTGAAGCAACTTATACCATGTTACTACATGCTGGACCTGAAATTGCTGTGGCATCAACCAAGGCTTATACAGCGCAAATTGCTGCCCTTGCTTTCCTTTCAAAAGCAGTTGGAGAAGCCAATGGTAAAAAAGAAGCGCTAGAATTTGACTTGGTACATGAATTATCCATTGTCGCTCAGTCTATTGAAGCTAGTCTTTCGGAGCGAGAAGTTATTGAAAAGAAGGTTGCTAATCTTTTAGCAACATCACGTAATGCTTTTTATATTGGTCGTGGTAATGACTATTATGTGGCTATGGAAGCATCACTCAAATTAAAAGAAATTTCATATATTCAATGTGAAGGCTTTGCTGCTGGAGAATTAAAACATGGAACCATTTCCCTTATTGAAGAGGGCACACCTGTTCTTGCCTTGATTTCATCTAGTGAGACTGTTGCTGCTCATACGCGCGGAAATATCCAAGAAGTTGCTGCTCGAGGTGCCAATGTCTTAACTGTTGTTGAAGAAGGTTTAAATAAGGAAGAAGATGATGTGGTTGTCAATCAAGTCCATCCTTATCTTTCAAGTATTTCAATGGTTATTCCAACGCAATTGATCGCATACTATGCCTCACTTCAACGTGGTCTTGATGTTGATAAACCACGTAATTTGGCTAAAGCTGTTACTGTTGAATAG","5.00","-18.71","65413","MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIYVINQPENGRLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQATEENAHPHASATGRLVLVHNGVIENYLQIKENYLAGHNLKGETDTEIAVHLIGQFVTDGLSVLESFKKALHIIEGSYAFALIDSQNPDIIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQFMEIHDKELVVLTKDTAQVSDYDGNPVERQAYTAELDLSDIGKGTYPYYMLKEIDEQPTVMRKLISTYANENGKLTVDPAIVKSVQEADRIYILAAGTSYNAGFASKSMIETLTDTPVELGIASEWGYNMPLLSKKPMFILLSQSGETADSRQVLVKANAMGVPSLTITNVPGSTLSREATYTMLLHAGPEIAVASTKAYTAQIAALAFLSKAVGEANGKKEALEFDLVHELSIVAQSIEASLSEREVIEKKVANLLATSRNAFYIGRGNDYYVAMEASLKLKEISYIQCEGFAAGELKHGTISLIEEGTPVLALISSSETVAAHTRGNIQEVAARGANVLTVVEEGLNKEEDDVVVNQVHPYLSSISMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE","1127623","For other 'glm' genes see SMu1301 (glmM) and SMu1488 (glmU). From Genbank:[gi:13878506]This enzyme catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.","L-glutamine-D-fructose-6-phosphate amidotransferase","Cytoplasm","Several matches in gapped BLAST to L-glutamine-D-fructose-6-phosphate amidotransferase: residues 1-604 are 83% similar to the enzyme in S.pyogenes (gi15675233) and are 79% similar to the protein from S.pneumoniae (gi15902289).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0944 (0.0).","

InterPro
IPR000583
Domain

Glutamine amidotransferase, class-II
PF00310	$\"[2-194]T$	GATase_2
PS00443	$\"[1-6]?$	GATASE_TYPE_II

InterPro
IPR001347
Domain

Sugar isomerase (SIS)
PF01380	$\"[287-413]T$ $\"[459-590]T$	SIS

InterPro
IPR005855
Family

Glucosamine-fructose-6-phosphate aminotransferase, isomerising
TIGR01135	$\"[2-604]T$	glmS

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10490	$\"[242-458]T$	G3DSA:3.40.50.10490
G3DSA:3.60.20.10	$\"[2-241]T$	G3DSA:3.60.20.10
PTHR10937	$\"[2-604]T$	PTHR10937
SSF53697	$\"[244-604]T$	SSF53697
SSF56235	$\"[2-239]T$	SSF56235

","BeTs to 13 clades of COG0449COG name: Glucosamine-fructose-6-phosphate aminotransferase, contains aminotransferase and phosphosugar isomerase domainsFunctional Class: MThe phylogenetic pattern of COG0449 is -MtkYqvcebrhuj---lin-Number of proteins in this genome belonging to this COG is 1","***** IPB000583 (Glutamine amidotransferase class-II) with a combined E-value of 2.6e-23. IPB000583A 24-34 IPB000583B 69-78 IPB000583C 99-127 IPB000583D 588-603***** IPB001347 (SIS domain) with a combined E-value of 2.3e-09. IPB001347A 70-78 IPB001347B 340-365","Residues 468-603 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD305006) which is seen in Q9WZS0_THEMA.Residues 63-238 are 70% similar to a (AMIDOTRANSFERASE ASPARAGINE AMINOTRANSFERASE GLUTAMINE) protein domain (PD000635) which is seen in GLMS_LACLA.Residues 428-506 are 82% similar to a (AMINOTRANSFERASE AMIDOTRANSFERASE) protein domain (PD002268) which is seen in GLMS_LACLA.Residues 391-420 are 90% similar to a (AMINOTRANSFERASE AMIDOTRANSFERASE) protein domain (PD404634) which is seen in GLMS_LACLA.Residues 280-422 are 63% similar to a (PROTEOME COMPLETE AMINOTRANSFERASE ISOMERASE) protein domain (PD000868) which is seen in Q9KG45_BACHD.Residues 2-59 are 79% similar to a (AMIDOTRANSFERASE AMINOTRANSFERASE GLUTAMINE) protein domain (PD001242) which is seen in Q9JN50_LACLC.Residues 519-604 are 77% similar to a (AMINOTRANSFERASE AMIDOTRANSFERASE) protein domain (PD002422) which is seen in GLMS_LACLA.Residues 252-388 are 78% similar to a (AMINOTRANSFERASE AMIDOTRANSFERASE) protein domain (PD002531) which is seen in GLMS_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 09:25:33 2006","Mon Feb 25 08:54:08 2002","Thu Aug 3 09:23:24 2006","Mon Feb 25 08:53:22 2002","Mon Feb 25 08:53:22 2002","Mon Feb 25 08:53:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1086 is paralogously related (blast p-value < 1e-3) to SMu0028, a predicted phosphoribosylpyrophosphate amidotransferase.","Mon Feb 25 09:03:06 2002","Thu Aug 3 09:23:24 2006","pdb1MOSA Chain A, Isomerase Domain Of Glucosamine 6-Phosphate... 243 3e-065pdb1GDOB Chain B, Glutaminase Domain Of Glucosamine 6-Phospha... 185 9e-048pdb1AO0A Chain A, Glutamine Phosphoribosylpyrophosphate (Prpp... 85 3e-017","SMU.1187c","","Residues 2 to 134 (E-value = 2.3e-45) place SMu1086 in the GATase_2 family which is described as Glutamine amidotransferases class-II (PF00310)Residues 285 to 419 (E-value = 2e-30) place SMu1086 in the SIS family which is described as SIS domain (PF01380)Residues 457 to 590 (E-value = 4.1e-23) place SMu1086 in the SIS family which is described as SIS domain (PF01380)","Thu Aug 3 09:23:24 2006","","","","Fernandez-Herrero,L.A., Badet-Denisot,M.A., Badet,B. andBerenguer,J.glmS of Thermus thermophilus HB8: an essential gene for cell-wallsynthesis identified immediately upstream of the S-layer geneMol. Microbiol. 17 (1), 1-12 (1995)PubMed: 7476196","","Mon Feb 25 09:02:15 2002","1","","","SMU.1187c","110" "SMu1087","1130149","1129595","555","ATGGTTAAACGTGACTTTATCAGAAATATTCTTCTGGTTCTGCTAGCAGTTCTTGCTTTGCTTTTATTAAGAGTGTTTGTCTTTTCAAACTATCGGGTAAGGCAAGCAGATGCTAATAACTTTTTGAAATCGGGAGATCTCGTTACGATCACAAAGAATGAAAAGCCTAATTATAAGGATTTTGTTGTCTATAAGGTTGCTGGTAAGGATCGTATTGGCCGTATTATTGGTAAACCAAAAGATAGTGTTACTTATATGGATGATATTTTTTACCTTAATCATAAGGCTGAAGACCAATCTTATATTAATGATTTAAAAAATAAATATCATACAAAAAATGGAGAAAATCTTTTTACTTCTGATTTTTCAATTTCTAGTATTACAAAGGGAAAATACCAAAAAATTCCTAAGGGGCAATACTTGATTTTAAATGATAATAGGACAAATAAGAAAGATAGCCGAACATTTGGTTTAATTAAGAAATCTCAAATTAAAGGAGTTGTCACTTTTAGGATTTTGCCGCTCAAGAAATTTGGATTTGTTTCGAAAGAGTAG","10.80","18.47","21279","MVKRDFIRNILLVLLAVLALLLLRVFVFSNYRVRQADANNFLKSGDLVTITKNEKPNYKDFVVYKVAGKDRIGRIIGKPKDSVTYMDDIFYLNHKAEDQSYINDLKNKYHTKNGENLFTSDFSISSITKGKYQKIPKGQYLILNDNRTNKKDSRTFGLIKKSQIKGVVTFRILPLKKFGFVSKE","1129610","","signal peptidase I","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to signal peptidase I: residues 1-184 are 57% similar to the enzyme in S.pyogenes (gi|15675234|). Residues 24-180 are 37% similar to the protein from B.caldolyticus (gi|729934|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0942 (1e-49).","

InterPro
IPR000223
Family

Peptidase S26A, signal peptidase I
PR00727	$\"[71-83]T$ $\"[135-154]T$	LEADERPTASE
TIGR02227	$\"[9-176]T$	sigpep_I_bact

InterPro
IPR006198
Domain

Peptidase S24, S26A and S26B
PF00717	$\"[42-95]T$	Peptidase_S24

InterPro
IPR011056
Domain

Peptidase S24 and S26, C-terminal region
G3DSA:2.10.109.10	$\"[21-179]T$	Pept_S24_S26_C
SSF51306	$\"[24-181]T$	Pept_S24_S26_C

InterPro
IPR014037
Family

Peptidase S26A
PTHR12383	$\"[16-108]T$ $\"[133-179]T$	Peptidase_S26A

noIPR
unintegrated

unintegrated
PTHR12383:SF1	$\"[16-108]T$ $\"[133-179]T$	PTHR12383:SF1

","BeTs to 10 clades of COG0681COG name: Signal peptidase IFunctional Class: NThe phylogenetic pattern of COG0681 is AmTKYqvCeBrhuj--OLinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000508 (Signal peptidase) with a combined E-value of 2.3e-14. IPB000508A 20-50 IPB000508B 54-65 IPB000508C 71-81 IPB000508D 135-154","Residues 55-168 are 32% similar to a (I PEPTIDASE SIGNAL PROTEASE) protein domain (PD001438) which is seen in Q9KE28_BACHD.Residues 24-109 are 30% similar to a (I PEPTIDASE SIGNAL COMPLETE) protein domain (PD097105) which is seen in LEP_STRPN.Residues 24-169 are 28% similar to a (INACTIVE PEPTIDASE IA SIGNAL) protein domain (PD204539) which is seen in LEPH_STAAU.Residues 91-169 are 40% similar to a (I PEPTIDASE SIGNAL HYDROLASE) protein domain (PD343894) which is seen in LEP_STAAU.Residues 42-184 are 32% similar to a (TYPE-I SIPA PEPTIDASE SIGNAL) protein domain (PD342889) which is seen in Q9ZG06_STACA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 09:11:35 2002","Mon Feb 25 09:06:43 2002","Wed Oct 16 08:52:20 2002","Mon Feb 25 09:06:43 2002","Mon Feb 25 09:06:43 2002","Mon Feb 25 09:06:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1087 is paralogously related (blast p-value < 1e-3) to SMu1704, a predicted signal peptidase I.","Mon Feb 25 09:12:57 2002","","No significant hits to the NCBI PDB database.","SMU.1188c","","Residues 1 to 166 (E-value = 2.4e-06) place SMu1087 in the Peptidase_S26 family which is described as Signal peptidase I (PF00461)","Mon Feb 25 09:06:43 2002","","","","Meijer,W.J., de Jong,A., Bea,G., Wisman,A., Tjalsma,H., Venema,G.,Bron,S. and van Dijl,J.M.The endogenous Bacillus subtilis (natto) plasmids pTA1015 andpTA1040 contain signal peptidase-encoding genes: identification ofa new structural module on cryptic plasmidsMol. Microbiol. 17 (4), 621-631 (1995)PubMed: 8801417Cregg,K.M., Wilding,I. and Black,M.T.Molecular cloning and expression of the spsB gene encoding anessential type I signal peptidase from Staphylococcus aureusJ. Bacteriol. 178 (19), 5712-5718 (1996)PubMed: 8824617","","Mon Feb 25 09:11:35 2002","1","","","SMU.1188c","796" "SMu1088","1130470","1130228","243","ATGGGATTACTTTGGTCACTAATAGTAGGAGCACTTATTGGAGCAATTGCAGGTGCTATTACGAATAGAGGAAAAGCAATGGGTTGTATTGCTAATATTTTTGCAGGATTAGTTGGTTCTTGGGCAGGTCAAGCTTTGTTTGGCAGTTGGGGACCTAGTTTAGCTGGTATGGCTCTTCTTCCGTCTATTCTGGGAGCAGTAATTGTGGTAGCTGTTATTTCCTTCTTTTTTGGTGAAAATTAA","8.40","0.93","7961","MGLLWSLIVGALIGAIAGAITNRGKAMGCIANIFAGLVGSWAGQALFGSWGPSLAGMALLPSILGAVIVVAVISFFFGEN","1130243","","conserved hypothetical protein","Membrane, Extracellular","Limited matches in gapped BLAST to unknowns and conserved hypothetical proteins :residues 3-78 are 55% similar to Lactococcus lactis subsp. lactis (gi|15673874|) and residues 1-75 are 50% similar to S.pyogenes (gi|15675224|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1140 (5e-18).","

InterPro
IPR007341
Family

Transglycosylase-associated protein
PF04226	$\"[33-78]T$	Transgly_assoc

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 33-65 are 81% similar to a (PROTEOME COMPLETE YDAS Y) protein domain (PD026667) which is seen in Q9CEF0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 09:16:12 2002","Mon Feb 25 09:16:12 2002","Mon Feb 25 09:16:12 2002","Mon Feb 25 09:16:12 2002","","Mon Feb 25 09:16:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1088 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 09:16:12 2002","","No significant hits to the NCBI PDB database.","SMU.1189c","","Residues 33 to 78 (E-value = 2.7e-15) place SMu1088 in the Transgly_assoc family which is described as Transglycosylase associated protein (PF04226)","Mon Feb 25 09:16:12 2002","24379617","","","","","","1","","","SMU.1189c","934" "SMu1089","1132263","1130761","1503","ATGAATAAACGCGTAAAAATTGTTGCAACTTTAGGTCCAGCGGTAGAAATCCGTGGTGGTAAAAAATTTGGTGAAGATGGCTATTGGGGTGAAAAGCTTGATGTTGAAGCTTCAGCAGCAAAAATTGCTGAATTGATTACAGAAGGAGCCAATGTTTTTCGTTTTAACTTTTCACATGGTGACCATGCTGAGCAAGGTGAACGTATGGCGACTGTACGTCGCGCGGAAGAATTGGCACGTCAAAAGGTTGGATTCCTTCTTGATACTAAAGGACCTGAAATGCGTACAGAATTGTTTGCAGATGGTGTCAAAGAATATGAATATAAGACTGGTGATAAACTTCGTATAGCAACTAAACAAGGCATTGAATCAACTAAGGATGTCATTGCTTTAAATGTTGCAGGCGGTCTTGATATTTATGATGATGTTGCTGTCGGTCAGACTATTCTTATTGATGATGGGAAACTTGGCCTTACAGTAACCGCTAAAGATATTACAACTCGCGAGTTTGAAGTAACCGTTGAAAATGATGGCATTATTGCTAAACAAAAAGGTGTCAATATTCCTAATACTAAAATTCCTTTCCCAGCACTTGCTGAGCGTGATAATGCAGATATTCGCTTTGGTTTGGAACAAGGTCTTAACTTTATTGCTATTTCTTTTGTTCGTACTGCTAAGGATGTTAATGAAGTTCGTCAAATTTGTAAAGAAACAGGTAACGAGCACGTAAAACTTTTTGCTAAAATTGAAAATCAACAAGGTATTGATAACATTGATGAAATCATTGATGCAGCTGACGGTATCATGATTGCTCGCGGTGACATGGGTATTGAAGTGCCGTTTGAAATGGTTCCAGTTTATCAAAAAATGATTATCACGAAAGTTAATGCAGCAGGGAAGTCAGCTATCACAGCAACAAATATGCTTGAAACAATGACTGACAAACCACGTGCAACACGTTCCGAAGTCTCTGATGTCTTTAATGCTGTCATTGATGGTACTGATGCAACAATGCTTTCTGGTGAATCAGCTAATGGTAAGTATCCAGTTGAAGCTGTTCGTACCATGGCAACAATTGATAAGAATGCTCAAACACTTCTTAATGAATATGGCCGTTTGAATTCAGATAATTTGCCACGTACCAACAAGACTGAGGTTGTCGCTTCAGCTGTTAAAGATGCGACTAAATCAATGGATATTAAATTGGTTGTTACAATTACAGAATCTGGTAACACAGCTCGTTTAATTTCAAAATACCGTCCGGATGCAGATATCTTAGCTTTAACATTTGATGAAAAAGTCCAAAAATCATTGATGATTAACTGGGGAGTTATTCCAATCTTAACAGAAAAACCTGCATCTACTGATGATATGTTTGAAATTGCAGAAAAAGCAGCTCTTAAATCAGGTTTGGTAGAGTCTGGTGACAACATCGTTATTGTTGCTGGTGTACCGGTTGGATCTGGTGGTACCAATACTATGCGTGTTCGTACCGTTCAATAA","4.90","-12.26","54357","MNKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAAKIAELITEGANVFRFNFSHGDHAEQGERMATVRRAEELARQKVGFLLDTKGPEMRTELFADGVKEYEYKTGDKLRIATKQGIESTKDVIALNVAGGLDIYDDVAVGQTILIDDGKLGLTVTAKDITTREFEVTVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVNEVRQICKETGNEHVKLFAKIENQQGIDNIDEIIDAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKSAITATNMLETMTDKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPVEAVRTMATIDKNAQTLLNEYGRLNSDNLPRTNKTEVVASAVKDATKSMDIKLVVTITESGNTARLISKYRPDADILALTFDEKVQKSLMINWGVIPILTEKPASTDDMFEIAEKAALKSGLVESGDNIVIVAGVPVGSGGTNTMRVRTVQ","1130776","","pyruvate kinase","Cytoplasm","Several matches in gapped BLAST to pyruvate kinase: residues 1-500 are 82% similar to the enzyme in S.pyogenes (gi|15675235|) and are 78% similar to the protein from S.pneumoniae (gi|15900780|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0941 (0.0).","

InterPro
IPR001697
Family

Pyruvate kinase
PTHR11817	$\"[4-16]T$ $\"[38-499]T$	Pyruvate_kinase
TIGR01064	$\"[3-499]T$	pyruv_kin

InterPro
IPR011037
Domain

Pyruvate kinase, beta-barrel-like
SSF50800	$\"[93-195]T$	PK_B_barrel_like

InterPro
IPR015793
Domain

Pyruvate kinase, barrel
PD001009	$\"[191-368]T$	Pyruvate_kinase
PR01050	$\"[81-97]T$ $\"[214-228]T$ $\"[245-271]T$ $\"[272-296]T$ $\"[297-321]T$ $\"[322-340]T$ $\"[341-357]T$	PYRUVTKNASE
PF00224	$\"[2-373]T$	PK

InterPro
IPR015794
Domain

Pyruvate kinase, alpha/beta
G3DSA:3.40.1380.20	$\"[365-499]T$	Pyrv_Knase_a/b
PF02887	$\"[384-498]T$	PK_C

InterPro
IPR015795
Domain

Pyruvate kinase, C-terminal-like
SSF52935	$\"[351-500]T$	Pyruvate_kinase

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.60	$\"[2-363]T$	G3DSA:3.20.20.60
SSF51621	$\"[2-374]T$	SSF51621

","BeTs to 11 clades of COG0469COG name: Pyruvate kinaseFunctional Class: GThe phylogenetic pattern of COG0469 is -m-kY-vCEbrh--gpo-in-Number of proteins in this genome belonging to this COG is 1","***** IPB001697 (Pyruvate kinase family) with a combined E-value of 7.2e-138. IPB001697A 30-65 IPB001697B 83-97 IPB001697C 134-160 IPB001697D 180-228 IPB001697E 253-297 IPB001697F 298-320 IPB001697G 321-353 IPB001697H 402-429","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:37:25 2002","Mon Feb 25 10:37:25 2002","Wed Oct 16 08:53:53 2002","Mon Feb 25 10:36:39 2002","Mon Feb 25 10:36:39 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1089 is paralogously related (blast p-value < 1e-3) to SMu0930, a predicted citrate lyase, beta subunit.","Mon Feb 25 10:40:01 2002","Mon Feb 25 10:36:39 2002","pdb|1PKY|A Chain A, Pyruvate Kinase From E. Coli In The T-State... 347 1e-096pdb|1E0U|A Chain A, Structure R271l Mutant Of E. Coli Pyruvate ... 347 2e-096pdb|1E0T|A Chain A, R292d Mutant Of E. Coli Pyruvate Kinase >gi... 345 8e-096","SMU.1190c","","Residues 2 to 373 (E-value = 5.7e-204) place SMu1089 in the PK family which is described as Pyruvate kinase, barrel domain (PF00224)Residues 384 to 498 (E-value = 5.7e-55) place SMu1089 in the PK_C family which is described as Pyruvate kinase, alpha/beta domain (PF02887)","Mon Feb 25 10:36:39 2002","","","","Llanos,R.M., Harris,C.J., Hillier,A.J. and Davidson,B.E.Identification of a novel operon in Lactococcus lactis encodingthree enzymes for lactic acid synthesis: phosphofructokinase,pyruvate kinase, and lactate dehydrogenaseJ. Bacteriol. 175 (9), 2541-2551 (1993)PubMed: 8478320","","Mon Feb 25 10:39:01 2002","1","","","SMU.1190c","109" "SMu1090","1133350","1132337","1014","ATGAAACGTATTGCTGTTTTGACCAGTGGCGGAGACGCTCCTGGTATGAATGCTGCCGTTCGTGCAGTCGTTCGTAAAGCAATTTCTGAAGGAATGGAAGTTTGCGGAATCAATCGTGGTTATGCTGGTATGGTTGAAGGAGATATCTTCCCGCTTGACGCTAAAGGTGTATCAAACATCCTTTCTCGTGGAGGGACATTTCTCCAGTCCGCACGTTACCCTGAATTTGCAAAGCTTGAGGGGCAATTAAAGGGTATCGAGCAACTCAAAAAGCATGGCATTGAAGGAGTCGTTGTTATAGGTGGCGATGGTTCTTATCATGGTGCGATGCGCTTGACTGAGCATGGTTTTCCTGCTGTCGGTCTTCCGGGTACAATTGATAACGATATCGTAGGAACTGATTATACAATTGGTTTTGATACTGCAGTAAACACTGCTACGGATGCACTTGATAAAATTCGTGATACCTCATTTAGTCACGGCAGAACTTTTGTTGTTGAGGTTATGGGACGTAATGCAGGAGATATTGCTCTTTGGTCTGGTATTGCTGCCGGTGCTGACCAAATTATTATTCCTGAAGAGCCCTATGATATTAAAGAGGTTGTCGCCAATGTGAAAAATGGCTATCTTAGTAAGTCTAAAAACCACCATCTCATTGTTCTTGCCGAAGGCGTTATGCATGGTGAAGAGTTTGCTGCTCAGATGAAGGAAGCAGGAGATAATAGTGATCTTCGTGTTACCAACCTTGGGCATATCCTGCGCGGTGGTGCACCAACTCCTCGTGATCGTGTGATTGCTTCATGGATGGGAGCCCATGCCGTTGAATTGCTCAGGGAAGGAAAAGGCGGTCTTGCCATTGGTATTCAAAATGAGGAGTTGGTTGAGCATCCAATTCTTGGATCTGCGGAAGACGGTGCACTCTTTAGTTTAACAGAACAAGGCGAGATCGTTGTAAATAATCCGCATAAAGCACGTCTTGATTTTGCTGCTTTGAATCGTGATTTGTCCAACTAA","5.50","-9.38","35758","MKRIAVLTSGGDAPGMNAAVRAVVRKAISEGMEVCGINRGYAGMVEGDIFPLDAKGVSNILSRGGTFLQSARYPEFAKLEGQLKGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAVGLPGTIDNDIVGTDYTIGFDTAVNTATDALDKIRDTSFSHGRTFVVEVMGRNAGDIALWSGIAAGADQIIIPEEPYDIKEVVANVKNGYLSKSKNHHLIVLAEGVMHGEEFAAQMKEAGDNSDLRVTNLGHILRGGAPTPRDRVIASWMGAHAVELLREGKGGLAIGIQNEELVEHPILGSAEDGALFSLTEQGEIVVNNPHKARLDFAALNRDLSN","1132352","","6-phosphofructokinase","Cytoplasm","Several matches in gapped BLAST to 6-phosphofructokinase: residues 1-337 are 81% similar to the enzyme in S.thermophilus (gi|13629190|). Residues 1-336 are 78% similar to the protein from S.pyogenes (gi|15675236|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0940 (1e-147).","

InterPro
IPR000023
Family

Phosphofructokinase
PD000707	$\"[112-177]T$	Ppfruckinase
PR00476	$\"[6-25]T$ $\"[31-44]T$ $\"[93-109]T$ $\"[120-137]T$ $\"[138-156]T$ $\"[158-174]T$ $\"[176-193]T$ $\"[213-225]T$ $\"[241-263]T$	PHFRCTKINASE
PTHR13697	$\"[117-298]T$	Ppfruckinase
PF00365	$\"[2-279]T$	PFK
PS00433	$\"[245-263]N$	PHOSPHOFRUCTOKINASE

InterPro
IPR012003
Family

ATP-dependent phosphofructokinase, prokaryotic
PIRSF000532	$\"[2-320]T$	ATP_PFK_prok

InterPro
IPR012828
Family

6-phosphofructokinase
TIGR02482	$\"[3-302]T$	PFKA_ATP

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.450	$\"[2-215]T$	G3DSA:3.40.50.450
SSF53784	$\"[1-298]T$	SSF53784

","BeTs to 11 clades of COG0205COG name: 6-phosphofructokinaseFunctional Class: GThe phylogenetic pattern of COG0205 is ----YqVCebrh--gpOLIN-Number of proteins in this genome belonging to this COG is 1","***** IPB000023 (Phosphofructokinase) with a combined E-value of 5.3e-77. IPB000023A 2-20 IPB000023B 64-101 IPB000023C 137-191 IPB000023D 243-274","Residues 2-279 are 82% similar to a (KINASE TRANSFERASE PHOSPHOFRUCTOKINASE) protein domain (PD000707) which is seen in K6PF_STRTR.Residues 280-337 are 75% similar to a (PHOSPHOFRUCTOKINASE TRANSFERASE) protein domain (PD131569) which is seen in K6PF_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:43:17 2002","Mon Feb 25 10:43:17 2002","Wed Oct 16 08:54:47 2002","Mon Feb 25 10:42:26 2002","Mon Feb 25 10:42:26 2002","Mon Feb 25 10:42:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1090 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 10:42:26 2002","Mon Feb 25 10:42:26 2002","pdb|6PFK|D Chain D, Phosphofructokinase, Inhibited T-State >gi|... 360 2e-100pdb|4PFK| Phosphofructokinase (E.C.2.7.1.11) Complex With Fr... 360 2e-100pdb|2PFK|D Chain D, Phosphofructokinase (E.C.2.7.1.11) 296 2e-081","SMU.1191c","","Residues 2 to 279 (E-value = 2e-168) place SMu1090 in the PFK family which is described as Phosphofructokinase (PF00365)","Mon Feb 25 10:42:26 2002","","","","Llanos,R.M., Harris,C.J., Hillier,A.J. and Davidson,B.E.Identification of a novel operon in Lactococcus lactis encodingthree enzymes for lactic acid synthesis: phosphofructokinase,pyruvate kinase, and lactate dehydrogenaseJ. Bacteriol. 175 (9), 2541-2551 (1993)PubMed: 8478320Xiao,Q. and Moore,C.H.The primary structure of phosphofructokinase from LactococcuslactisBiochem. Biophys. Res. Commun. 194 (1), 65-71 (1993)PubMed: 8333872","","Mon Feb 25 10:45:12 2002","1","","","SMU.1191c","342" "SMu1091","1136537","1133433","3105","GTGTTTGCACAATTAGATACTAAAACCGTTTATAGTTTTATGGATAGCCTGATTGACTTAAAATCTTATATTAAGAAAGCTAAGGAGATGGGCTATTCGCATATTGGTATTATGGATGGAGATAATCTCTACGGAGCTTTTCATTTTATAAAAGAAGCTCAAAAAGAAAAACTAGTCCCTATTCTTGGTCTTGAACTGGATTTATTTTTATCTGATGATTTGACGACCGTATGTTTTATTGCTCAAAATACAATTGGCTACCACAATCTCTTAAAAATTTCGACAGCCAAGATGACAGGTCAACAGCTTTTCTCTGATATTGAAGAATTTATGGATGGTCTTGCTATAATTGTTCCTTATTTTGAAGGAATTGATCAAATGGATTTTCCCTTTTCTTTTTATATTGGCGTCAGAAAAGATACTCCTCAGCTGGATTTTAAAAGAGACATTTTACCTTTACATACAGTACGTTATTATGATAATGATGATACAGAGACCTTACAAATATTACATGCTATTAGAGATAATCTTCCTTTAAGGGAAGTGCCTCCTGTTTCTAAAGATCAGTATCTGTTTTCTCAGGAAGAGATGGAACAAATTTTTGAGGAACGTTTTCCACAGAGCTTGTTAAATTTAGAAAAGTTGGTTGCCAATGTTTCTTATCAGTTTGATACTGATTTGAAATTGCCTCGTTTTAGTCGAGATAAACCTGCTGTTGTGGAATTAAAAGAATTAGCGCAAAAGGGACTTGTAGAAAAGAAACTTTTGAGTGATGACTATCAAAAGCGATTATCTGATGAATTGGCTGTCATTCATCAAATGGGCTTTGATGATTATTTTTTGATTGTCTGGGACTTACTGCGCTTTGGCCGTTCCCAGCATTATTATATGGGAATGGGACGTGGTTCTGCAGCAGGGAGTCTTGTGGCTTATGCCCTTGATATTACAGGTATTGATCCTGTTAAGAATGATTTACTTTTTGAGCGTTTTCTTAATGAGGAACGCTACAGCATGCCAGATATTGATATTGATCTTCCTGATATTTATCGGAGTCAGTTTTTAAATTATGTCCGTGATCGTTATGGTTCAACACATTCAGCACAAATTGTGACCTTTTCGACCTTTGGTGCCAGACAGGCAATTCGTGATGTTTTTAAGCGTTTTGGAGCGACTGAATATGAACTCAGTCAAATCACTAAAAAAATTAGTTTCCGCGATAATTTGACAAGTGTTTATGACAAAAAGATTGCTTTTCGCCAACTCATTAATAGTAAAATCGAATATCAGCGTGCGTTCGAAATTGCGAAAAAAATTGAAGGAAATCCTCGTCAAACTTCCATTCATGCGGCTGGAATTGTGATGAGTGATGATAATTTAACAGATCACATTCCTCTCAAAACAGGTGAAGAAATGATGATCACGCAATATGATGCTCCAGCTGTTGAAGCTAATGGTCTTTTAAAAATGGACTTTCTCGGACTGCGTAATCTTACTTTTATTCAAAAAATGCAGGAAAAAGTAGCACAAGATTATGGTCATGCCATAGATATCAGAGCTATTGATTTAGAAGATAAAGAGACCTTAGCACTTTTTGCCGCTGGAGATACCAAAGGCATTTTTCAGTTTGAAGCAGCCGGAGCTATCAATCTTTTGAAAAGAATTAAACCTTCTCGTTTTGAAGAAGTTGTTGCAACTACCAGTCTCAATCGTCCTGGTGCTAGTGATTATACTGAAAATTTTATTCGCCGAAAATATGGGCAAGAAGAAGTGGATTTGATTGATTCATCAATTGCTTCTATTTTAAAATCGACTTATGGTATTATGCTTTATCAGGAACAAGTGATGCAAATTGCTCAGATTTTTGCTGGTTTTACATTAGGGAAAGCTGATTTATTACGCCGTGCTATGTCAAAAAAAAATACTGTTGAAATGCAAAAAATGGAAAAAGATTTTTTGCAGGGTGCTGATCAGTTAGGACGAGATCTAAAAGTTGCCCAAAACTTGTTTGCAAGAATGGCTAAGTTTGCTGGTTATGGCTTTAATCGCAGTCATGCCTACGCATACTCAGCTTTAGCATTCCAAATGGCTTATTTCAAAGTACACTATCCAGCGGTGTTCTTTGATGTCATGTTAAATTACTCTAGCGGTGATTATCTCAGCAATGCTTTAGAGACTCATTTTAAATTAGGACCTTTGTCCATTAATACGATTCCTTATTCTGATAAAATTAGTCATGGTCAGATTTACTTGGGTTTAAAAAACATCAAGGGTTTAAATCGTGATTTTGCCTATTGGATTATTGGAAACCGTCCTTTTTCTAGTATTGAAGATTTTTTAATCAGAATACCCGAAAAGTATCAGAAAACTGAGATTATCACTCCTTTAATTCAAGTAGGCCTTTTTGATCAGTTTGATAAAAACCGCCAGAAAATCGTTGTCAATCTAGAACACCTTTTTACTTTTGTCAATGAATTAGGGAGTTTGTTTGCTGATTCTTCCTATAATTGGATAGAAGCGCAAGATTATACCAATGCTGAAAAATATCAGCTGGAACAAGATATCATTGGTGCAGGAGTTAGTCCGCATCCTCTAATAGAAATTGCAAAGCACTCCAGCAGACATTTAATTGCTCTGACTGACCTCGTTGAAGGAAATGAAGCTACCATATTAGCTCAAATTGAGTCCATTAGAATTATTCGAACGAAATCCAGAGGCGAGCAAATGGCTTTTCTAAGTGTGACAGATACTAAGAAGAAATTGAATATCACTCTTTTTCCAGAGACTTATCAAAAGTACAAAAATTTCTTAACAGAAAAAACGATTTATTATTTTACTGGGAAAATACAGGAGCGTGATAATCAATTGCAAATGATTTTACATCAATTAGACTCTGCCTCAACAGAAAAATGCTGGATTAAGTTACAAAATCATGATTGTGATAGAGAGATATCAGAAATTTTAGCAGCTTACCCTGGAAATATTCCAGTAGTTTTACATTACTCAAATACTAAAGAAACTTTCCAAAGCAGCCGCTATTTTGTCGCTAAGGATCCAGAATTGCAGGAAAAGTTGGCTTATTATGCTCTGAAAACGCTTTTTCAATAA","5.90","-14.73","118887","MFAQLDTKTVYSFMDSLIDLKSYIKKAKEMGYSHIGIMDGDNLYGAFHFIKEAQKEKLVPILGLELDLFLSDDLTTVCFIAQNTIGYHNLLKISTAKMTGQQLFSDIEEFMDGLAIIVPYFEGIDQMDFPFSFYIGVRKDTPQLDFKRDILPLHTVRYYDNDDTETLQILHAIRDNLPLREVPPVSKDQYLFSQEEMEQIFEERFPQSLLNLEKLVANVSYQFDTDLKLPRFSRDKPAVVELKELAQKGLVEKKLLSDDYQKRLSDELAVIHQMGFDDYFLIVWDLLRFGRSQHYYMGMGRGSAAGSLVAYALDITGIDPVKNDLLFERFLNEERYSMPDIDIDLPDIYRSQFLNYVRDRYGSTHSAQIVTFSTFGARQAIRDVFKRFGATEYELSQITKKISFRDNLTSVYDKKIAFRQLINSKIEYQRAFEIAKKIEGNPRQTSIHAAGIVMSDDNLTDHIPLKTGEEMMITQYDAPAVEANGLLKMDFLGLRNLTFIQKMQEKVAQDYGHAIDIRAIDLEDKETLALFAAGDTKGIFQFEAAGAINLLKRIKPSRFEEVVATTSLNRPGASDYTENFIRRKYGQEEVDLIDSSIASILKSTYGIMLYQEQVMQIAQIFAGFTLGKADLLRRAMSKKNTVEMQKMEKDFLQGADQLGRDLKVAQNLFARMAKFAGYGFNRSHAYAYSALAFQMAYFKVHYPAVFFDVMLNYSSGDYLSNALETHFKLGPLSINTIPYSDKISHGQIYLGLKNIKGLNRDFAYWIIGNRPFSSIEDFLIRIPEKYQKTEIITPLIQVGLFDQFDKNRQKIVVNLEHLFTFVNELGSLFADSSYNWIEAQDYTNAEKYQLEQDIIGAGVSPHPLIEIAKHSSRHLIALTDLVEGNEATILAQIESIRIIRTKSRGEQMAFLSVTDTKKKLNITLFPETYQKYKNFLTEKTIYYFTGKIQERDNQLQMILHQLDSASTEKCWIKLQNHDCDREISEILAAYPGNIPVVLHYSNTKETFQSSRYFVAKDPELQEKLAYYALKTLFQ","1133448","For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0074 (dnaK);SMu075 (dnaJ); SMu0745 (dnaG); SMu1745 (dnaI); SMu1746 (dnaB);SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC). From Genbank:[gi:14194672]This enzyme is a complex,multichain enzyme responsible for most of the replicative synthesis in bacteria.It also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.","DNA-polymerase III subunit alpha","Cytoplasm","Several matches in gapped BLAST to DNA polymerase III (alpha subunit): residues 1-1034 are 64% similar to the enzyme in S.pyogenes (gi15675237) and are 58% similar to the protein from S.pneumoniae (gi15902839).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0939 (0.0).","

InterPro
IPR003141
Domain

Polymerase and histidinol phosphatase, N-terminal
SM00481	$\"[3-70]T$	POLIIIAc

InterPro
IPR004013
Domain

PHP, C-terminal
PF02811	$\"[9-123]T$	PHP

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[887-965]T$	tRNA_anti

InterPro
IPR004805
Family

DNA polymerase III, alpha subunit
TIGR00594	$\"[2-925]T$	polc: DNA polymerase III, alpha subunit

InterPro
IPR011708
Domain

Bacterial DNA polymerase III, alpha subunit
PF07733	$\"[189-659]T$	DNA_pol3_alpha

","BeTs to 12 clades of COG0587COG name: DNA-dependent DNA polymerase III alpha chainFunctional Class: LThe phylogenetic pattern of COG0587 is -----qvCeBRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003141 (PHP domain N-terminal region) with a combined E-value of 2.4e-24. IPB003141A 3-40 IPB003141B 327-342 IPB003141C 678-688","Residues 329-637 are 81% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD004180) which is seen in DP3A_STRPY.Residues 680-962 are 61% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD004426) which is seen in DP3A_STRPY.Residues 297-328 are 90% similar to a (DNA POLYMERASE SUBUNIT ALPHA) protein domain (PD005473) which is seen in DP3A_STRPY.Residues 2-66 are 72% similar to a (DNA POLYMERASE III DNA-DIRECTED) protein domain (PD001693) which is seen in DP3A_STRPY.Residues 638-679 are 61% similar to a (DNA POLYMERASE SUBUNIT TRANSFERASE) protein domain (PD374259) which is seen in DP3A_STRPY.Residues 965-1034 are 44% similar to a (DNA POLYMERASE SUBUNIT TRANSFERASE) protein domain (PD388633) which is seen in DP3A_STRPY.Residues 80-228 are 48% similar to a (DNA POLYMERASE SUBUNIT TRANSFERASE) protein domain (PD398982) which is seen in DP3A_STRPY.Residues 80-293 are 41% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD003212) which is seen in DP3A_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 09:11:30 2006","Thu Aug 3 09:11:30 2006","Thu Aug 3 09:11:30 2006","Mon Feb 25 10:48:02 2002","Mon Feb 25 10:48:02 2002","Mon Feb 25 10:48:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1091 is paralogously related (blast p-value < 1e-3) to SMu0110, a predicted DNA polymerase III, alpha subunit.","Mon Feb 25 10:53:43 2002","","No significant hits to the NCBI PDB database.","SMU.1192c","","Residues 3 to 68 (E-value = 1.3e-12) place SMu1091 in the PHP_N family which is described as PHP domain N-terminal region (PF02231)Residues 887 to 965 (E-value = 1.1e-06) place SMu1091 in the tRNA_anti family which is described as OB-fold nucleic acid binding domain (PF01336)","Thu Aug 3 09:11:30 2006","","","","Bruck,I. and O'Donnell,M.The DNA replication machine of a gram-positive organismJ. Biol. Chem. 275 (37), 28971-28983 (2000)PubMed: 10878011","","Thu Aug 3 09:11:30 2006","1","","","SMU.1192c","108" "SMu1092","1136715","1137086","372","ATGGCTTGGAAATTTAATGAGAAATCCCCTATTTATCTTCAAATTGCCAATCATATCAAAATGCAAATTATCAGTCAAGAAATCAAACCCGGCCAACAACTAGCCACAGTTAGAGATTTAGCAGAAGAAGCTGGCGTAAATCCTAATACTATGCAACGTGCTTTTACATCACTTGAACAAGAAGGGATGGTCTTTTCAGTTAGAACTTCGGGACGTTTCGTGACAAAGGACCAGCAGTTAATTGAAGAAGAAAGACACAAGTTAGCTCAAACAGAACTTGAAGACTTTATCAACAAGATGACAACAATTGGCTTTAGCAAAGATCGTTTAACTACTATACTGGACCAATATATTAAAGGAGAGACGAAATGA","6.60","-0.52","14176","MAWKFNEKSPIYLQIANHIKMQIISQEIKPGQQLATVRDLAEEAGVNPNTMQRAFTSLEQEGMVFSVRTSGRFVTKDQQLIEEERHKLAQTELEDFINKMTTIGFSKDRLTTILDQYIKGETK","1137095","","transcriptional regulator, GntR family","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator,GntR family: residues 1-123 are 62% similar to the enzyme in S.pyogenes (gi|15675238|). Residues 1-120 are 55% similar to the protein from S.pneumoniae (gi|15903601|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0938 (1e-42).","

InterPro
IPR000524
Domain

Bacterial regulatory protein GntR, HTH
PR00035	$\"[34-48]T$ $\"[48-64]T$	HTHGNTR
PF00392	$\"[11-74]T$	GntR
SM00345	$\"[15-74]T$	HTH_GNTR
PS50949	$\"[9-77]T$	HTH_GNTR

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[4-77]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[8-76]T$	SSF46785

","BeTs to 4 clades of COG1725COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1725 is ------vc-Br----------Number of proteins in this genome belonging to this COG is 1","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 1.4e-11. IPB000524 34-74","Residues 10-74 are 41% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD371622) which is seen in Q9CFH6_LACLA.Residues 27-120 are 31% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD069824) which is seen in YHCF_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 10:58:54 2002","Mon Feb 25 10:57:26 2002","Wed Oct 16 08:55:34 2002","Mon Feb 25 10:57:26 2002","Mon Feb 25 10:57:26 2002","Mon Feb 25 10:57:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1092 is paralogously related (blast p-value < 1e-3) to SMu0582, and SMu0973, both predicted transcriptional regulators.","Mon Feb 25 10:58:54 2002","","No significant hits to the NCBI PDB database.","SMU.1193","","Residues 11 to 74 (E-value = 1.8e-13) place SMu1092 in the GntR family which is described as Bacterial regulatory proteins, gntR family (PF00392)","Mon Feb 25 10:57:26 2002","24379621","","","","","","1","","","SMU.1193","925" "SMu1093","1137083","1137790","708","ATGACAGAACAACTGCCCTTATTACAATTACATCATATTACTAAGAAGTTTGGAAACAAGCTAGCTCTTGATGATATTTCTTTAAAATTACCAAAAGGTAAAATAATTGGACTGTTGGGACCAAATGGAAGCGGTAAGACGACACTGATTAAATTAGCTAATGGACTGTTACAACCTACTGCAGGTGAAATTGTGATTAACGGACTCAGACCTTGTCCTGAAACAAAATCGCTCATTTCCTATCTTCCCGATACCAGCTATTTAAGTGATAAAATGAAGGTCCATGACATTTTAAAACTATTTGAAGATTTCTATGTTGATTTTGATAGGCAAAAAGCCGAACAATTACTGGAAGATTTAGCCATTGCTCAAAGCGAAAAATTAAAAAATCTTTCTAAAGGAAACAAGGAAAAGGTTCAGCTTATTCTGGTTATGAGTCGCAAAGCAAAACTTTACATTTTGGATGAACCCATTGGTGGTGTTGATCCAGCTGCACGTGATTATATTTTAAAAACAATTATTAATAACTACTCAGAAGATGCATCTGTTCTTATTTCAACTCATTTAATTTCGGATATTGAGCAGGTTTTAGATGAAGTTATTTTTATCAACCAAGGAAAGATTGTTTTACAAGAAAATGTAGATGATTTGCGTGAACAATACGCACAATCAATCGATCACATTTTTAGAGAGAAATTTAGAGCCTAG","6.40","-1.84","26451","MTEQLPLLQLHHITKKFGNKLALDDISLKLPKGKIIGLLGPNGSGKTTLIKLANGLLQPTAGEIVINGLRPCPETKSLISYLPDTSYLSDKMKVHDILKLFEDFYVDFDRQKAEQLLEDLAIAQSEKLKNLSKGNKEKVQLILVMSRKAKLYILDEPIGGVDPAARDYILKTIINNYSEDASVLISTHLISDIEQVLDEVIFINQGKIVLQENVDDLREQYAQSIDHIFREKFRA","1137799","For other components see SMu1094 (MSD1).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Numerous matches in gapped BLAST to ABC transporter, ATP-binding proteins.Residues 7-234 are 64% similar to gi|15675239| from S.pyogenes. Residues 5-235 are 56% similar to gi|15903602| from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1980 (3e-25).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[131-173]T$	ABC_transporter
PF00005	$\"[33-206]T$	ABC_tran
PS50893	$\"[8-230]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[32-207]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[7-220]T$	G3DSA:3.40.50.300
PTHR19222	$\"[8-232]T$	PTHR19222
PTHR19222:SF16	$\"[8-232]T$	PTHR19222:SF16
SSF52540	$\"[6-222]T$	SSF52540

noIPR
unintegrated

unintegrated
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[63-85]?$ $\"[115-137]?$ $\"[169-189]?$ $\"[199-221]?$ $\"[240-260]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
PS51257	$\"[1-25]T$	PROKAR_LIPOPROTEIN

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 27-206 are 21% similar to a (DOMAIN OF UNKNO N) protein domain (PD180857) which is seen in O86209_ENTFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 12:55:15 2002","Mon Feb 25 12:55:15 2002","Mon Feb 25 12:55:15 2002","Mon Feb 25 12:55:15 2002","","Mon Feb 25 12:55:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1095 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 12:55:15 2002","","No significant hits to the NCBI PDB database.","SMU.1196c","","No significant hits to the Pfam 11.0 database","Mon Feb 25 12:55:15 2002","24379624","","","","","","1","","","SMU.1196c","1030" "SMu1096","1139764","1140378","615","ATGAAAGTGAAATTAAGCAAACGTTATATTTTAATGCAAAAAATCATTCAGGCTTTAGGAATTTTAGCCTTAATTGCTTCAGTCATTTTAGTTATCTGGTTTTATAAATTAGGCATTTTAAATGACAGCAACGCTTTGAAGGATCTTGTACACCATCACAAAGTTTTAGGTCCTTTAATCTTTATTCTCGTTCAGATTTTCCAAATTGTTTTCCCTGTTATCCCAGGCGGCGTCACTACTGTTGCTGGTTTTCTTATTTTTGGTACTTGGCTTGGTTTCATTTTAAATTACATCGGTATTATTATTGGGAGTGTCTTACTCTTCCTTCTGGTAAAGTGGTTAGGTCGTAAGTTTATTTTGCTTTTTATGAAAGAAGATACTTTTTACAAATACGAAGCCAAACTGGAAAGTGATACTTATGAAAAACTATTCATTTTTTGTATGCTTTCTCCTGTGTCGCCTGCTGATATTATGGTAATGATTACTGGTTTAACAAGCATGAGTCTTAAGCGCTTCACTGCTATTATGGTCATCACCAAACCATTGTCTATTATTTGTTATAGTTATTTCTGGATATACGGTAGTAAGTTACTAGAATTTTTATTTCATAAGTAA","10.40","10.85","23371","MKVKLSKRYILMQKIIQALGILALIASVILVIWFYKLGILNDSNALKDLVHHHKVLGPLIFILVQIFQIVFPVIPGGVTTVAGFLIFGTWLGFILNYIGIIIGSVLLFLLVKWLGRKFILLFMKEDTFYKYEAKLESDTYEKLFIFCMLSPVSPADIMVMITGLTSMSLKRFTAIMVITKPLSIICYSYFWIYGSKLLEFLFHK","1140387","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypotheticals:residues 92-203 are 70% similar to a hypothetical protein from S.pyogenes (gi|15675241|) and residues 33-193 are 33% similar to the protein from S.pneumoniae (gi|15903607|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0914 (2e-60).","

InterPro
IPR015414
Domain

SNARE associated Golgi protein
PF09335	$\"[74-191]T$	SNARE_assoc

noIPR
unintegrated

unintegrated
PTHR12677	$\"[8-178]T$	PTHR12677

","BeTs to 3 clades of COG0398COG name: Uncharacterized ACR, YdjX/UPF0043 familyFunctional Class: SThe phylogenetic pattern of COG0398 is ----y--cEBR----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 33-198 are 36% similar to a (PROTEOME YJBF COMPLETE) protein domain (PD400187) which is seen in Q9CH44_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 12:58:50 2002","Mon Feb 25 12:58:02 2002","Mon Feb 25 12:58:02 2002","Mon Feb 25 12:58:02 2002","","Mon Feb 25 12:58:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1096 is paralogously related (blast p-value < 1e-3) to SMu0779, and SMu1179, both predicted hypothetical proteins.","Mon Feb 25 12:58:50 2002","","No significant hits to the NCBI PDB database.","SMU.1197","","No significant hits to the Pfam 11.0 database","Mon Feb 25 12:58:02 2002","24379625","","","","","","1","","","SMU.1197","" "SMu1097","1142083","1140884","1200","ATGAATGAATTTGAAGATTTGCTAAACAGTGTTAGTGAAGTAAATCCAGGCGACGTTGTGACTGCAGAAGTCTTAACTGTAGATGGAGAACAAGCAAACCTTGTTATTGACGGGACAGGTGTTGAAGCTGTATTGACACTTCGCGAATTGACCAATGATCGTAATGCTGACATTAATGACTTTGTCAAAGCTGGTGATAAAGTCGAGGTGCTTGTTCTTCGCCAAGTTGTTGGTAAAGATACTGATACAGTAACTTTCCTTGTCTCTAAAAAACGCCTAGAAGCTCGCAAGGCTTGGGACAAACTTGTTGGTCGTGAAGGTGACGTTGTGACTGTTAAGGGCACACGTGCTGTTAAGGGTGGACTTTCTGTTGAATTTGAAGGACTTCGTGGTTTTATTCCAGCTTCAATGATTGATACCCGTTTTGTTCGCAATACTGAAAAATTTGTTGGTCAGCAATTCGAAGCAAAAATCAAAGAAATTGATCCTTCAGAAAATCGCTTTATCCTTTCTCGTCGTGATGTGGTTGAAGCTGCAGCTGCAAAGGCGCGTGAGGAAGTCTTCTCAAGACTTGCTGTTGGTGATATCGTGACTGGTACTGTTGCTCGTTTGACAAGTTTTGGTGCTTTTATTGACCTTGGTGGTGTTGACGGACTTGTTCATATTACTGAATTATCGCATGAACGTAATGTTTCACCAAAATCAGTCGTCACTGTTGGTGAAGAAATTCAAGTGAAGGTGCTTGCTATTGATGAAGAAGCAGGCCGAGTTTCACTGTCTCTTAAAGCAACAACTCCTGGACCATGGGATGGTGTTGAACAAAAACTTGCCGCTGGTGATGTTATCGAAGGCAAAGTAAAACGCTTGACAGACTTTGGCGCTTTTGTTGAAGTTCTTCCAGGTATTGATGGTTTGGTTCATATTTCACAAATTTCGCACAAACGTGTCGAAAATCCAAAGGATGTTCTTTCAGTCGGTCAAGATGTTACTGTTAAAGTTCTTGATGTTAATACTGCTGATGAACGTGTCTCACTTTCCATCAAAGCGCTTGAAGAACGTCCAGCTCAGGATGAAAGCAACGGAGAAAAACGTCAATCTCGTCCTCGTCGTCAAAAACGTCAAGATAAACGTGACTATGAACTTCCAGAAACTCAAACTGGATTCTCAATGGCTGACTTGTTTGGTGATATTGAATTATAA","4.80","-13.98","43674","MNEFEDLLNSVSEVNPGDVVTAEVLTVDGEQANLVIDGTGVEAVLTLRELTNDRNADINDFVKAGDKVEVLVLRQVVGKDTDTVTFLVSKKRLEARKAWDKLVGREGDVVTVKGTRAVKGGLSVEFEGLRGFIPASMIDTRFVRNTEKFVGQQFEAKIKEIDPSENRFILSRRDVVEAAAAKAREEVFSRLAVGDIVTGTVARLTSFGAFIDLGGVDGLVHITELSHERNVSPKSVVTVGEEIQVKVLAIDEEAGRVSLSLKATTPGPWDGVEQKLAAGDVIEGKVKRLTDFGAFVEVLPGIDGLVHISQISHKRVENPKDVLSVGQDVTVKVLDVNTADERVSLSIKALEERPAQDESNGEKRQSRPRRQKRQDKRDYELPETQTGFSMADLFGDIEL","1140899","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1841 (rps10);SMu1838 (rps19); SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1692 (rpsR) and SMu1694 (rpsF).","30S ribosomal protein S1","Cytoplasm","Several matches in gapped BLAST to ribosomal protein S1: residues 1-399 are 83% similar to the protein in S.pyogenes (gi15674934) and are 76% similar to the protein from S.pneumoniae (gi15902808).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1150 (0.0).","

InterPro
IPR000110
Family

Ribosomal protein S1
PR00681	$\"[17-35]T$ $\"[110-126]T$ $\"[128-145]T$ $\"[157-177]T$ $\"[214-235]T$ $\"[292-311]T$ $\"[331-349]T$	RIBOSOMALS1

InterPro
IPR003029
Domain

RNA binding S1
PF00575	$\"[103-173]T$ $\"[190-262]T$ $\"[275-348]T$	S1
SM00316	$\"[15-91]T$ $\"[105-173]T$ $\"[192-262]T$ $\"[277-348]T$	S1
PS50126	$\"[17-74]T$ $\"[107-173]T$ $\"[194-262]T$ $\"[279-348]T$	S1

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[92-175]T$ $\"[194-265]T$ $\"[279-374]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
PTHR10724	$\"[276-399]T$	PTHR10724
SSF50249	$\"[4-165]T$	Nucleic_acid_OB

","BeTs to 12 clades of COG0539COG name: Ribosomal protein S1Functional Class: JThe phylogenetic pattern of COG0539 is ----YqvCebrhuj--olinxNumber of proteins in this genome belonging to this COG is 2","***** PR00681 (Ribosomal protein S1 signature) with a combined E-value of 2.5e-35. PR00681D 110-126 PR00681E 128-145 PR00681F 157-177 PR00681G 214-235 PR00681H 292-311 PR00681I 331-349 PR00681A 194-212","Residues 13-197 are 26% similar to a (CHLOROPLAST RIBOSOMAL S1 30S) protein domain (PD400044) which is seen in RR1_PORPU.Residues 283-353 are 51% similar to a (RIBOSOMAL COMPLETE PROTEOME RNA-BINDING 30S REPEAT) protein domain (PD000709) which is seen in Q9LBD0_CORAM.Residues 97-196 are 56% similar to a (RIBOSOMAL 30S REPEAT RNA-BINDING) protein domain (PD002626) which is seen in Q9CHA0_LACLA.Residues 276-356 are 42% similar to a (PROTEOME COMPLETE RNA-BINDING) protein domain (PD337374) which is seen in YHGF_ECOLI.Residues 194-262 are 37% similar to a (RIBOSOMAL 30S RNA-BINDING REPEAT) protein domain (PD400698) which is seen in RS1_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 10 08:29:37 2006","Thu Aug 10 08:24:01 2006","Thu Aug 10 08:24:01 2006","Mon Feb 25 13:03:00 2002","Mon Feb 25 13:03:00 2002","Mon Feb 25 13:03:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1097 is paralogously related (blast p-value < 1e-3) to SMu0138, a predicted polyribonucleotide nucleotidyltransferase (PNPase) (alpha chain); SMu0682, a predicted a conserved hypothetical; SMu0443,a predicted polynucleotide nucleotidyltransferase and SMu1462,a predicted exoribonuclease R.","Mon Feb 25 13:03:00 2002","Thu Aug 10 08:24:01 2006","pdb1SRO S1 Rna Binding Domain, Nmr, 20 Structures 73 6e-014pdb1E3PA Chain A, Tungstate Derivative Of Streptomyces Antibi... 68 3e-012pdb1E3HA Chain A, Semet Derivative Of Streptomyces Antibiotic... 68 3e-012","SMU.1200c","","Residues 103 to 173 (E-value = 3.6e-14) place SMu1097 in the S1 family which is described as S1 RNA binding domain (PF00575)Residues 190 to 262 (E-value = 8.8e-28) place SMu1097 in the S1 family which is described as S1 RNA binding domain (PF00575)Residues 275 to 348 (E-value = 5.1e-30) place SMu1097 in the S1 family which is described as S1 RNA binding domain (PF00575)","Thu Aug 10 08:24:01 2006","","","","Yamit-Hezi,A., Levy,Z., Neuman,S. and Nudel,U.A Leuconostoc lactis protein with homology to ribosomal protein S1shares common epitopes and common DNA binding properties with amammalian DNA binding nuclear factorGene 185 (1), 99-103 (1997)PubMed: 9034319Eklund,E.A., Lee,S.W. and Skalnik,D.G.Cloning of a cDNA encoding a human DNA-binding protein similar toribosomal protein S1Gene 155 (2), 231-235 (1995)PubMed: 7721096Tsuzaka,K., Leu,A.K., Frank,M.B., Movafagh,B.F., Koscec,M.,Winkler,T.H., Kalden,J.R. and Reichlin,M.Lupus autoantibodies to double-stranded DNA cross-react withribosomal protein S1J. Immunol. 156 (4), 1668-1675 (1996)PubMed: 8568274","","Mon Feb 25 13:08:25 2002","1","","","SMU.1200c","128" "SMu1098","1142745","1142584","162","ATGGTTGGTTATCAATTAACAATTGGAAACAAACTTGTAGGTGAGATTGCTGAGATTGATGACAAGTTTGCTGTTATCAAAAATGCTGCAGTTGTTGATTTCCATAAAAATTTAGAAACTGCTGTTGAATCTATCATTCAAACCTATAATTTGAATCACTAA","4.50","-2.78","5831","MVGYQLTIGNKLVGEIAEIDDKFAVIKNAAVVDFHKNLETAVESIIQTYNLNH","1142599","","conserved hypothetical protein","Cytoplasm, Extracellular","Limited matches in gapped BLAST to hypotheticals:residues 3-52 are 66% similar to hypothetical protein from S.pyogenes (gi|15674933|) and residues 3-51 are 61% similar to hypothetical protein from S.pneumoniae (gi|15900745|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1151 (2e-13).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 25 13:11:50 2002","Mon Feb 25 13:11:36 2002","Mon Feb 25 13:11:36 2002","Mon Feb 25 13:11:36 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1098 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 13:11:36 2002","","No significant hits to the NCBI PDB database.","SMU.1201c","","No significant hits to the Pfam 11.0 database","Mon Feb 25 13:11:36 2002","24379627","","","","","","1","","","SMU.1201c","1016" "SMu1099","1143904","1142879","1026","ATGACAGTAGATTTAGATTGGAAAAATTTAGGATTTGAATATCACAAACTTCCATTTCGCTATATTTCTTACTACAAAGATGGGAAATGGGATGACGGTAAACTGACAGAAGATGCGACTCTCCACATTTCTGAAAGCTCACCAGCTCTTCATTATGGGCAAGAAGCTTTTGAAGGTTTGAAAGCCTACCGTACAAAAGATGGCTCTGTTCAGCTTTTCCGTCCTAATATGAATGCTGAGCGCTTACAACGTACAGCTGATCGTCTCTTGATGCCGCAAGTGCCAACTGACAAATTCATTGATGCTGCCAAACAAGTCGTTCGTGCCAATGAAGAGTATGTTCCACCATATGGTACAGGGGCAACGCTTTATCTTCGCCCACTTTTGATTGGTGTCGGCGATGTGATCGGTGTTCATCCAGCTGATGAATATATCTTTACCATCTTTGCTATGCCGGTAGGTAACTACTTTAAAGGTGGTTTGGCTCCGACGAATTTTCTTATTCAAGATGATTATGACCGCGCTGCGCCACATGGCACAGGAGCTGCCAAAGTTGGCGGGAACTACGCGGCGAGTCTTTTGCCAGGTAAGGTTGCCCATGAACGCCAGTTTTCAGATGTTATTTATCTTGACCCAGCAACACATACTAAGATTGAAGAAGTCGGTTCAGCTAACTTCTTTGGTATCACTAAAGATAATGAGTTTATTACACCTCTTAGTCCGTCCATTCTTCCTTCTGTTACCAAATATTCTCTGCTTTATTTAGCTGAACATCGTTTCGGCATGAAAGCCATTGAAGGCGATGTCTGCGTAGATGAATTAGATAAATTTGTTGAAGCAGGAGCCTGCGGTACAGCAGCTGTTATCTCACCAATCGGAGGTGTACAGCACGGTGATGATTTCCATGTCTTTTACAGTGAAACGGAAGTTGGTCCTGTAACGCATAAATTGTATGATGAGTTAACAGGTATCCAATTCGGCGATGTTAAAGCACCAGAGGGCTGGATATATAAAGTTGATGACTAA","4.90","-14.43","37718","MTVDLDWKNLGFEYHKLPFRYISYYKDGKWDDGKLTEDATLHISESSPALHYGQEAFEGLKAYRTKDGSVQLFRPNMNAERLQRTADRLLMPQVPTDKFIDAAKQVVRANEEYVPPYGTGATLYLRPLLIGVGDVIGVHPADEYIFTIFAMPVGNYFKGGLAPTNFLIQDDYDRAAPHGTGAAKVGGNYAASLLPGKVAHERQFSDVIYLDPATHTKIEEVGSANFFGITKDNEFITPLSPSILPSVTKYSLLYLAEHRFGMKAIEGDVCVDELDKFVEAGACGTAAVISPIGGVQHGDDFHVFYSETEVGPVTHKLYDELTGIQFGDVKAPEGWIYKVDD","1142894","For other 'ilv' genes see SMu1931 (ilvd); SMu0209 (ilvB); SMu0210 (ilvH); SMu0211 (ilvC) and SMu0212 (ilvA)","branched-chain amino acid aminotransferase","Cytoplasm","Several matches in gapped BLAST to branched-chain amino acid aminotransferase: residues 1-340 are 84% similar to the enzyme in S.pneumoniae (gi|15900741|). Residues 1-324 are 86% similar to the protein from S.agalactiae (gi|15186715|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1152 (1e-180).","

InterPro
IPR001544
Family

Aminotransferase, class IV
PD001961	$\"[204-320]T$	Aminotrans_IV
PTHR11825	$\"[21-340]T$	Aminotrans_IV
PF01063	$\"[32-322]T$	Aminotran_4
PS00770	$\"[220-249]?$	AA_TRANSFER_CLASS_4
SSF56752	$\"[4-337]T$	Aminotrans_IV

InterPro
IPR005786
Family

Branched-chain amino acid aminotransferase II
PIRSF006468	$\"[1-340]T$	BCAT1
PTHR11825:SF2	$\"[21-340]T$	B_amino_transII
TIGR01123	$\"[30-339]T$	ilvE_II

noIPR
unintegrated

unintegrated
G3DSA:3.20.10.10	$\"[188-319]T$	G3DSA:3.20.10.10
G3DSA:3.30.470.10	$\"[4-177]T$	G3DSA:3.30.470.10

","BeTs to 11 clades of COG0115COG name: Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyaseFunctional Class: E,HThe phylogenetic pattern of COG0115 is amt-YQvCEBRhUJ------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001544 (Aminotransferases class-IV) with a combined E-value of 7.4e-36. IPB001544A 50-61 IPB001544B 72-86 IPB001544C 124-138 IPB001544D 179-189 IPB001544E 243-258 IPB001544F 279-292","Residues 279-335 are 46% similar to a (AMINOTRANSFERASE BRANCHED-CHAIN ACID BCAT) protein domain (PD038213) which is seen in ILVE_MYCTU.Residues 57-321 are 46% similar to a (AMINOTRANSFERASE ACID BRANCHED-CHAIN PYRIDOXAL PHOSPHATE) protein domain (PD001961) which is seen in Q9SNY8_SOLTU.Residues 285-340 are 80% similar to a (AMINOTRANSFERASE BRANCHED-CHAIN ACID) protein domain (PD116145) which is seen in Q9CN73_PASMU.Residues 57-181 are 80% similar to a (AMINOTRANSFERASE BRANCHED-CHAIN ACID PYRIDOXAL) protein domain (PD330724) which is seen in Q9CG22_LACLA.Residues 184-339 are 29% similar to a (AMINOTRANSFERASE BRANCHED-CHAIN ACID) protein domain (PD247056) which is seen in Q9Y885_COCCA.Residues 277-339 are 47% similar to a (AMINOTRANSFERASE ACID BRANCHED-CHAIN) protein domain (PD343880) which is seen in ILVE_HELPJ.Residues 183-284 are 76% similar to a (AMINOTRANSFERASE BRANCHED-CHAIN ACID BIOSYNTHESIS) protein domain (PD331987) which is seen in Q9CG22_LACLA.Residues 52-292 are 24% similar to a (AMINOTRANSFERASE LYASE ACID) protein domain (PD338947) which is seen in ILVE_ARCFU.Residues 4-55 are 71% similar to a (AMINOTRANSFERASE BRANCHED-CHAIN ACID) protein domain (PD238689) which is seen in Q9CG22_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:57:55 2002","Mon Feb 25 13:15:32 2002","Wed Oct 16 08:57:55 2002","Mon Feb 25 13:15:32 2002","Mon Feb 25 13:15:32 2002","Mon Feb 25 13:15:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1099 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Feb 25 13:15:32 2002","Mon Feb 25 13:15:32 2002","pdb|1A3G|A Chain A, Branched-Chain Amino Acid Aminotransferase ... 112 8e-026","SMU.1203c","","Residues 32 to 322 (E-value = 3.4e-113) place SMu1099 in the Aminotran_4 family which is described as Aminotransferase class IV (PF01063)","Mon Feb 25 13:15:32 2002","","","","","","","1","","","SMU.1203c","385" "SMu1100","1146603","1144147","2457","ATGTCCAATATTCAAATCATGTCCCTTGAGGACATCATGGGAGAGCGTTTCGGTCGTTACTCCAAATACATCATTCAAGAACGGGCTTTGCCAGATATTCGCGATGGTCTCAAGCCCGTACAGCGCCGTATTCTTTATTCTATGAATAAAGATGGCAATACATATGATAAAGGTTACCGTAAATCAGCTAAGTCTGTCGGTAATGTTATGGGGAATTTCCACCCGCACGGGGATTCTTCAATTTATGATGCCATGGTTCGTATGAGTCAGGATTGGAAGAACCGCGAAACCCTGATTGAAATGCACGGGAACAACGGTTCTATGGACGGTGATCCGCCAGCAGCCATGCGTTATACAGAAGCGCGCCTATCAGAGATTGCAGATTATTTGCTCCAAGATATTGACAAGAATACGGTAGCTTGGGCTTGGAACTTTGATGATACCGAAAAAGAACCAACTGTTTTGCCAGCGGCCTTTCCTAATCTCTTGGTCAATGGTGCAACAGGGATTTCTGCGGGTTATGCGACCGATATTCCACCGCACAATTTAGCAGAAGTAATTGATACAGTTGTCTATCTTATTGATCACCCATCAGCTAAGCTCGATAAACTCATGGAATTTCTACCCGGACCCGATTTTCCAACAGGAGCCATTATTCAAGGTAAAGATGAAATTCGCAAAGCTTACGAAACAGGTAAAGGACGCGTTGTTGTTCGCTCTCGCACTGAAATTGAAAATCTTAAGGGTGGGAAGAAGCAGATTGTAGCGACAGAGATTCCTTATGAAGTCAATAAAGCAGCTCTAGTTAAGAAAATTGATGATGTTCGTCTTAACAATAAGGTTCCTGGAATTGCCGAAGTTCGTGACGAATCTGACCGTGAGGGCCTGCGCATTGCTATCGAGCTCAAGAAAGATGCTGATGAGCAAACGATTCTAAATTATCTTTTTAAATACACCGATTTGCAAATCAACTATAATTTTAATATGGTGGCTATCGATAATTATACGCCGCGGCAAGTTGGCATTATTCCAATGTTAACGAGCTATATCGCCCATCGTAAAGACATTATTGTTGCACGTTCTAAATTTGACAAGGAAAAAGCCGAAAAACGTCTCCATATTGTTGAAGGGCTTATTCGTGTTATTTCCATCCTGGACGAGGTCATTGCACTTATTCGGGCTTCGGAAAATAAAGCTGATGCCAAGGAAAATCTTAAGATTAGCTATGACTTTTCAGAAGAACAGGCAGAGGCTATTGTCACCTTGCAACTGTATCGTTTGACCAATACCGATATTGTTACTTTGGAAAATGAAGAAGCTGAATTGCGTGAACGTATTACAACTCTCAATGCTATTATTGGTGATGAGCGCACCATGTATAATGTTATGAAGCGTGAACTGCGTGAAGTCAAAAAGAAATTTGGCAATCCACGTTTGAGTGAATTACAGGCTGAGACACAAACCATTGAAATTGACACAGCCAGTCTGATTGTGGAAGAAGAAACCTATGTTAGTGTCACACGCGGCGGTTATATTAAACGAACAAGTCCACGTTCTTTCAATGCTTCAACAGTTGAAGAACTCGGTAAGCGTGATGATGATGATGTCATCTTCATTCAGAATGCTAAGACCACACAAGAACTGCTGATTTTTACTAATTTAGGCAATGTTATTTATCGGCCGATTCATGAATTAGCTGATATCCGCTGGAAGGAAATCGGTGAGCACCTCAGCCAAAACATTACCAATTTTGCAACGGATGAAGAAATTCTTTATGTTGATTTAGTGGATCATTTTGAAGAAGGTACCTATTATGCTGCAACTCGTCTGGGGCAAATTAAACGGTTTGAACGTCGCGATTTGACACCTTGGCGGAGTTATAAGTCTAAAGCAGCCAAATATGCTAAATTAAAAGGTGATGACGATCAAGTTATCAGAATTTCACCAATTAAATTAGATGATGTGATGCTAATTACTGCTAGAGGCTATGCGCTTCGTTTCAATATTGAAGAAGTACCTATTGTCGGTCCTAAAGCAGCAGGGATTAAGGCTATTAACCTCAAAGAGGGGGATTCTTTGGCTACTGCCTTTATTGCCAATACGGATAGTATTTATATTTTGACACAAAGAGGCAGTCTCAAACGGATGACAACCAATCTTATCCCAGTGACTAGCCGTGCTAAACGTGGGCTTCAAGTACTTCGTGAGCTTAAGAGTAAACCTCATCGTGTTTTTGCGGCAGGACCAGTCTTTTCCGAAGCAGCAGGGGAGATTGACCTATTTACCACTGTAGGTGAACAAGGACAAGAAGAAATTCTAGAAATTCAATCGCAAAGTTTAGAAAAATACGAAGTTAATCTGGCTGAACTCTTGCTATCAGAACGGACTAGCAACGGTTCCTTTATCTCAGATACTATCTCTGATCAAGGAGTCTATGCAGCAAAAATCAAAATTTAA","5.40","-13.23","92524","MSNIQIMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTYDKGYRKSAKSVGNVMGNFHPHGDSSIYDAMVRMSQDWKNRETLIEMHGNNGSMDGDPPAAMRYTEARLSEIADYLLQDIDKNTVAWAWNFDDTEKEPTVLPAAFPNLLVNGATGISAGYATDIPPHNLAEVIDTVVYLIDHPSAKLDKLMEFLPGPDFPTGAIIQGKDEIRKAYETGKGRVVVRSRTEIENLKGGKKQIVATEIPYEVNKAALVKKIDDVRLNNKVPGIAEVRDESDREGLRIAIELKKDADEQTILNYLFKYTDLQINYNFNMVAIDNYTPRQVGIIPMLTSYIAHRKDIIVARSKFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKISYDFSEEQAEAIVTLQLYRLTNTDIVTLENEEAELRERITTLNAIIGDERTMYNVMKRELREVKKKFGNPRLSELQAETQTIEIDTASLIVEEETYVSVTRGGYIKRTSPRSFNASTVEELGKRDDDDVIFIQNAKTTQELLIFTNLGNVIYRPIHELADIRWKEIGEHLSQNITNFATDEEILYVDLVDHFEEGTYYAATRLGQIKRFERRDLTPWRSYKSKAAKYAKLKGDDDQVIRISPIKLDDVMLITARGYALRFNIEEVPIVGPKAAGIKAINLKEGDSLATAFIANTDSIYILTQRGSLKRMTTNLIPVTSRAKRGLQVLRELKSKPHRVFAAGPVFSEAAGEIDLFTTVGEQGQEEILEIQSQSLEKYEVNLAELLLSERTSNGSFISDTISDQGVYAAKIKI","1144162","For other 'par' genes see SMu1106 (parE).For DNA topoisomerase IV subunit B see SMu1106.","DNA topoisomerase IV subunit A","Cytoplasm","Several matches in gapped BLAST to DNA topoisomerase IV subunit C: residues 1-817 are 78% similar to the enzyme in S.agalactiae (gi15186714) and are 77% similar to the protein from S.pneumoniae (gi9230565).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1153 (0.0).","

InterPro
IPR002205
Domain

DNA topoisomerase, type IIA, subunit A or C-terminal
PD000742	$\"[43-118]T$	DNA_topoisoIV
PF00521	$\"[28-475]T$	DNA_topoisoIV
SM00434	$\"[7-460]T$	TOP4c

InterPro
IPR005741
Family

DNA topoisomerase IV, subunit A, Gram-positive
TIGR01061	$\"[4-742]T$	parC_Gpos

InterPro
IPR006691
Repeat

DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel
PF03989	$\"[500-544]T$ $\"[545-598]T$ $\"[652-701]T$ $\"[702-752]T$	DNA_gyraseA_C

InterPro
IPR013757
Domain

DNA topoisomerase, type IIA, subunit A, alpha-helical
G3DSA:1.10.268.10	$\"[365-454]T$	Topo_IIA_A_a

InterPro
IPR013758
Domain

DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta
G3DSA:3.90.199.10	$\"[26-292]T$	Topo_IIA_A/C_ab

InterPro
IPR013760
Domain

DNA topoisomerase, type IIA, central
SSF56719	$\"[26-483]T$	Topo_IIA_cen

noIPR
unintegrated

unintegrated
PTHR10169	$\"[27-195]T$	PTHR10169
PTHR10169:SF2	$\"[27-195]T$	PTHR10169:SF2
SSF101904	$\"[500-816]T$	SSF101904

InterPro
IPR002073
Domain

3'5'-cyclic nucleotide phosphodiesterase
PS00126	$\"[66-77]?$	PDEASE_I

InterPro
IPR003615
Domain

HNH nuclease
SM00507	$\"[9-67]T$	HNHc

noIPR
unintegrated

unintegrated
SSF81301	$\"[36-164]T$	SSF81301

InterPro
IPR003812
Family

Filamentation induced by cAMP protein Fic
PF02661	$\"[47-158]T$	Fic

","BeTs to 3 clades of COG2184COG name: Fic protein involved in cell divisionFunctional Class: DThe phylogenetic pattern of COG2184 is --------e-rhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB003812 (Fic (filamentation induced by cAMP) protein) with a combined E-value of 3.3e-35. IPB003812A 50-81 IPB003812B 105-126","Residues 45-147 are 38% similar to a (PROTEOME FILAMENTATION COMPLETE CELL) protein domain (PD035636) which is seen in O06366_MYCTU.Residues 26-192 are 53% similar to a (CELL FILAMENTATION PROTEOME COMPLETE) protein domain (PD009618) which is seen in O54679_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 08:08:17 2002","Tue Feb 26 08:01:14 2002","Wed Sep 27 13:13:30 2006","Tue Feb 26 08:01:14 2002","Tue Feb 26 08:01:14 2002","Tue Feb 26 08:01:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1103 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 08:04:23 2002","","No significant hits to the NCBI PDB database.","SMU.1207c","","Residues 47 to 158 (E-value = 2.4e-34) place SMu1103 in the Fic family which is described as Fic protein family (PF02661)","Tue Feb 26 08:01:14 2002","","","","Kawamukai,M., Matsuda,H., Fujii,W., Utsumi,R. and Komano,T.Nucleotide sequences of fic and fic-1 genes involved in cellfilamentation induced by cyclic AMP in Escherichia coliJ. Bacteriol. 171 (8), 4525-4529 (1989)PubMed: 2546924Utsumi,R., Nakayama,T., Iwamoto,N., Kohda,K., Kawamukai,M.,Tanabe,H., Tanaka,K., Takahashi,H. and Noda,M.Mutational analysis of the fic promoter recognized by RpoS (sigma38) in Escherichia coliBiosci. Biotechnol. Biochem. 59 (8), 1573-1575 (1995)PubMed: 7549107","","Tue Feb 26 08:06:31 2002","1","","","SMU.1207c","" "SMu1104","1149467","1148712","756","ATGCTTATGTTAAATAAACGTTATCAATTAGAAAATATTGACCTCACACACTTGACACCTGAACAGGTGGATAAGATTTCGACCGATAGCTTGGCGAAAATTCAGCAGTTTGTGACCGCTCATAGCGAAGAAGTGCCCCTCGTTAAGGGCGCTAGCCTTTTGGCAGAGCATTTGGAAAAATTTCAAAATAGCTTGCGCACTAGCACTAAAAGCCAGCTGTCTGAAAAGCTAGCTGCTGCCGATGCAGCTAGAGACAGCTCTCTCTCCATCTTGAACCAGTTTGTAAGAACTTACAGTCAGATTGATGAGGCAGATATTCAAGAGGCTTATGCGAAAATAGCAGAGCAGTTTAGCCAATTTAAAAATATTGCCAATAAGAGCTATGAAGAAGAAAGCGCCGCACTTGTGCAGTTGCTTAAAAAACTGAAGTCTAGTGATTTCAAAGCCAGCGTAAAAACACTTGGACTTGACAGCCACATTGCTCGTCTCGCACAAGCTCAAGAAACCTTTGAGACAGTTTATCAAGCCCGTCTTAATGAAGGCAAAGGAAAAGTTAAGAGCCAAAGTAAGGCCTTGAAACAAACTTTAATCGACAGCTATGACAGCCTAGTTGATTATATCGCTGTCAACGCCTACCACCACACTGACAAATCTCACCTCAAAGACCTGCTTGCCGACATCAATGCCATCCGCAAATGCTATAAGAAACGTAAGGTTGTGAAGAAAGCAGAAGCAGTGACAGAAGAAAAGGAATAA","8.90","3.65","28265","MLMLNKRYQLENIDLTHLTPEQVDKISTDSLAKIQQFVTAHSEEVPLVKGASLLAEHLEKFQNSLRTSTKSQLSEKLAAADAARDSSLSILNQFVRTYSQIDEADIQEAYAKIAEQFSQFKNIANKSYEEESAALVQLLKKLKSSDFKASVKTLGLDSHIARLAQAQETFETVYQARLNEGKGKVKSQSKALKQTLIDSYDSLVDYIAVNAYHHTDKSHLKDLLADINAIRKCYKKRKVVKKAEAVTEEKE","1148727","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.SMu1104 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 11:47:49 2002","Thu Oct 17 11:47:49 2002","Thu Oct 17 11:47:49 2002","Tue Feb 26 08:10:01 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1104 is paralogously related (blast p-value < 1e-3) to SMu0556, a predicted cell surface antigen I/II, SpaP protein precursor, pac protein precursor; saliva-interacting protein;PAGS-5.","Thu Oct 17 11:47:49 2002","","No significant hits to the NCBI PDB database.","SMU.1208c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 08:10:01 2002","24379633","","","","","","1","","","SMU.1208c","" "SMu1105","1151083","1149743","1341","ATGAATGTTGATTTTGGAGTTGCATCATATCTATTTGGGAAAAGTGCAGATTTTTTATTTGATACTTTTTTCGCTAAACTAGGTTTTAAAAACGATAAAGATAGGAAAAAGCTGAAGAAAATTGTTAATGAGTTTAAAGTGTCTATCAATGCACAACACAAAGAAAATCCTGATTTTGAAAATATAATGAGTTTTTGGAAAGAAAATCATATTTTTGAAGAACTTCTCAAAATTCGTTATAGTTTAAATAGCGATTTCAATAGTTATGATGAGCTTAAAAAGCATCTTGAGAAACAAAAGATGCCTGTTGAACTCAATATAGAATTATCGGAACAGTTAATGGACGAACTTGAACAAGAACTCTCTAGAGCAGTTCAAGAAGTGTCAAGTCTCTCCCAAGCTGATGTAGCGACTTTGAAAAATAATATAGAACCATTGCTGAGTAACTCGTTATCAACTCCATCTCAACCTGTTGTAAAAGATAAGAATAAACTACTAAATAATAAGAAAAATGGGAGGGAACAGCTATCCTTGGAAGAAAGTTGGAATAAGGTTTCTACTGAAACTGCTGAAAACGAAAGCTCATCGGTAGATAAAGATACTTCTCAAAAGAAAAGGGAGTCTCATTTAGCTTCCTCGATCTTTTTTGGAGATAAATTTGATTTAGCATTTCCAGATGTAGGTTCAGATTTTAAAGTATATTCTAAGGAAGCAGTGATAGAGAATCGACTAAATGAATTTTTTAGAGATTTTAACTATACAAGCTCTTCACCGGTAAGAAAAGTCAGAGGTGGTGAATGGGAGGATATTAGCACTTTCAAATTTGGAAGTGAAAGATCACTTTTAAAGACTATTACGAATGGGACGTATGAGTTAATTATTGATAAGGTCGTTGCGTTTAATTCTCCTGCTTATTGGAACAAATTTATTTTGATTCAAGTCAGACCCGATAACTTAGCCGAGATTACCGGCGATGATTATAATTCGAAAAATAGCAAAGAAGCATTCTATGCTTTTTCTGATAATAGGTATTATGACTATAAAGTAGGTGAGTATAGAAAATATCTTGTTGATGGTATTCTACATAGTTTAAATGGTGAAATAGAAAACAGGATTCGTTATCTAGAAAAGGATAATTTTCTAATTGTTCCTCGTTATCATCCTTTAGCAATTGAGTATAAATACTATGATAAGGTAAAAATTTTTCTTGAAGAACTCTTAGTTGCAAAGAACAGTGATGAAGAGAATGAAATACATATAAAGATTTCACGGTTCTCAAGAAGTATGTATAGAACACTTGCAGATGATAGAGAAAATCGTTTTGTTTATGATTATTATTAA","5.40","-8.25","52287","MNVDFGVASYLFGKSADFLFDTFFAKLGFKNDKDRKKLKKIVNEFKVSINAQHKENPDFENIMSFWKENHIFEELLKIRYSLNSDFNSYDELKKHLEKQKMPVELNIELSEQLMDELEQELSRAVQEVSSLSQADVATLKNNIEPLLSNSLSTPSQPVVKDKNKLLNNKKNGREQLSLEESWNKVSTETAENESSSVDKDTSQKKRESHLASSIFFGDKFDLAFPDVGSDFKVYSKEAVIENRLNEFFRDFNYTSSSPVRKVRGGEWEDISTFKFGSERSLLKTITNGTYELIIDKVVAFNSPAYWNKFILIQVRPDNLAEITGDDYNSKNSKEAFYAFSDNRYYDYKVGEYRKYLVDGILHSLNGEIENRIRYLEKDNFLIVPRYHPLAIEYKYYDKVKIFLEELLVAKNSDEENEIHIKISRFSRSMYRTLADDRENRFVYDYY","1149758","","hypothetical protein","Cytoplasm, Extracellular","No significant hit in gapped BLAST found.SMu1105 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 08:11:14 2002","Tue Feb 26 08:11:14 2002","Tue Feb 26 08:11:14 2002","Tue Feb 26 08:11:14 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1105 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 08:11:14 2002","","No significant hits to the NCBI PDB database.","SMU.1209c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 08:11:14 2002","24379634","","","","","","1","","","SMU.1209c","" "SMu1106","1153048","1151099","1950","TTGGCTAAAAAGAAAATTAATATTAATAATTATAATGATGATGCCATTCAGGTTTTAGAAGGTTTGGATGCCGTTCGTAAACGTCCGGGAATGTACATTGGTTCAACAGATGGGACAGGCCTGCACCATTTGGTTTGGGAAATCGTTGATAATGCTGTTGATGAAGCTCTGTCTGGTTTTGGTAATCAAATTGATGTTATCATTAACAAAGATGGCAGTATAACGGTAGCTGACCATGGACGAGGGATGCCAACAGGTAAACATGCTATGGGTATTCCGACTGTTGAGGTTATCTTTACTGTTCTTCATGCGGGCGGTAAGTTTGGACAAGGCGGCTATAAGACTTCTGGAGGCTTGCATGGTGTGGGTTCTTCTGTTGTCAATGCACTGTCCAGTTGGTTGGAAGTTGAAATTACACGCGATGGTATAGTTTACAAACAACGTTTTGAAGATGGTGGCAAACCAGCAACAACCTTGGAGAAGGTTGGCAAGGCTCCCAAGTCAAAATCGGGAACCAAGGTCACCTTTATGCCAGATGCCGGCATTTTCTCCACGACTAATTTTGTTTATAATACTATTGCTGAAAGACTTAATGAGTCCGCTTTTCTGCTTAAGAATGTGACTTTGACCCTGACAGATGAAAGATCAGAAGAGATAGAACATGTTGCCTTTCATTATGAAAATGGGGTTCAAGACTTTGTAGAATATCTTAATGAAGACAAGGAAATCTTGACACCAGTTATTTATTTTGAAGGGGAAGAAGCTGATTTTCAGGTAGAAGTTGCTCTGCAATACAATGATGGTTTCTCAGACAATATTCTCTCTTTTGTCAATAATGTTCGTACCAAAGATGGCGGAACGCACGAAACTGGACTCAAATCTGCTATCACCAAGGCTATGAATGATTATGCCAGAAAGACAGGTTTGCTCAAGGAAAAAGATAAGAATTTGGAAGGGTCAGATTACCGTGAAGGTTTATCTGCCGTCCTTTCTATACTTGTTCCAGAAGAACACCTGCAATTTGAAGGGCAAACCAAGGATAAGTTGGGAAGTCCCTTAGCCCGTCCCATCGTTGATGGTTTGGTGTTAGAGCAATTGACCTATTTCTTAATGGAAAATGGTGAATTAGCTTCCAATCTTATCCGCAAAGCTATTAAAGCGCGTGAAGCGCGTGAAGCAGCCCGTAAAGCCAGAGACGATAGCAGAAATGGCAAGAAAAATAAGAAAGATAAAGGTCTTCTTTCAGGAAAACTCACACCAGCCCAATCTAAAAACCCTAAAAAAAATGAACTCTATCTGGTCGAAGGAGATTCTGCCGGCGGGTCAGCCAAACAAGGACGCGATCGGAAGTTTCAGGCTATTCTCCCTTTACGTGGTAAGGTACTCAATACCGCTAAGGCCAAAATGGATGATATTATTAAAAACGAAGAAATCAATACCATGATTTATACCATAGGCGCTGGTGCCGGTCCTGATTTCAAGGTTGACGATTCTAATTACGATAAAATCATTATCATGACCGATGCCGATACCGATGGAGCCCATATTCAGACCCTGCTCTTAACCTTTTTCTATCGTTACATGAGACCATTGGTGGAGACAGGACATGTTTACATCGCCTTACCACCTCTCTACAAGATGTCTAAAGGTAAAGGAGCCAAAGAAGTCGTAGAATACGCATGGACAGACGGTGAGTTAGAAGATCTCCGCAAAAAATTTGGTAAAGGAGCTATGCTCCAGCGCTACAAGGGTCTGGGGGAAATGAATGCCGACCAGCTCTGGGAAACAACCATGAATCCTGAAAATCGTACCCTTATCCGTGTGACTATTGAAGATCTGGCACGTGCCGAACGCCGCGTCAACGTCCTCATGGGCGACAAGGTTCCGCCCCGTCGCAAATGGATTGAAGATAACGTTAAGTTTACCTTGGAGGAGAGTGGGGTGTTTTAG","6.40","-4.03","71965","MAKKKININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNQIDVIINKDGSITVADHGRGMPTGKHAMGIPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGIVYKQRFEDGGKPATTLEKVGKAPKSKSGTKVTFMPDAGIFSTTNFVYNTIAERLNESAFLLKNVTLTLTDERSEEIEHVAFHYENGVQDFVEYLNEDKEILTPVIYFEGEEADFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKAMNDYARKTGLLKEKDKNLEGSDYREGLSAVLSILVPEEHLQFEGQTKDKLGSPLARPIVDGLVLEQLTYFLMENGELASNLIRKAIKAREAREAARKARDDSRNGKKNKKDKGLLSGKLTPAQSKNPKKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNTAKAKMDDIIKNEEINTMIYTIGAGAGPDFKVDDSNYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVETGHVYIALPPLYKMSKGKGAKEVVEYAWTDGELEDLRKKFGKGAMLQRYKGLGEMNADQLWETTMNPENRTLIRVTIEDLARAERRVNVLMGDKVPPRRKWIEDNVKFTLEESGVF","1151114","For other 'par'genes see SMu1100 (parC).For DNA topoisomerase IV subunit C see SMu1100. From Genbank:[gi:3914290]This enzyme is essential for chromosome segregation.It is involved in the relaxation of supercoiled DNA activity.It performs the decatenation events required during the replication of circular DNA molecule","DNA topoisomerase IV subunit B","Cytoplasm","Several matches in gapped BLAST to DNA topoisomerase IV: residues 11-649 are 82% similar to the enzyme in S.pneumoniae (gi6851037) . Residues 11-649 are 78% similar to the protein from S.pyogenes (gi15674930).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1154 (0.0).","

InterPro
IPR000565
Family

DNA topoisomerase, type IIA, subunit B
PR01159	$\"[11-21]T$ $\"[187-202]T$ $\"[202-215]T$ $\"[249-267]T$ $\"[319-335]T$ $\"[369-383]T$ $\"[383-403]T$ $\"[481-490]T$ $\"[600-612]T$ $\"[616-632]T$	DNAGYRASEB

InterPro
IPR001241
Domain

DNA topoisomerase, type IIA, subunit B or N-terminal
PR00418	$\"[40-55]T$ $\"[75-88]T$ $\"[117-131]T$ $\"[275-288]T$ $\"[431-445]T$ $\"[497-513]T$ $\"[515-532]T$ $\"[535-547]T$ $\"[579-595]T$	TPI2FAMILY
SM00433	$\"[40-640]T$	TOP2c
PS00177	$\"[433-441]T$	TOPOISOMERASE_II

InterPro
IPR002288
Domain

DNA topoisomerase, type IIA, subunit B, C-terminal
PF00986	$\"[571-636]T$	DNA_gyraseB_C

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[19-237]T$	no description
PF02518	$\"[36-181]T$	HATPase_c
SM00387	$\"[36-182]T$	HATPase_c

InterPro
IPR005740
Family

DNA topoisomerase IV, subunit B, Gram-positive
TIGR01058	$\"[1-649]T$	parE_Gpos: DNA topoisomerase IV, B subunit

InterPro
IPR006171
Domain

TOPRIM
PF01751	$\"[429-540]T$	Toprim

InterPro
IPR011558
Domain

DNA topoisomerase, type IIA, subunit B, conserved region
PD149633	$\"[436-551]T$	Q8DTW0_STRMU_Q8DTW0;

InterPro
IPR013506
Domain

DNA topoisomerase, type IIA, subunit B, region 2
PF00204	$\"[229-400]T$	DNA_gyraseB

InterPro
IPR013759
Domain

DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta
G3DSA:3.40.50.670	$\"[395-602]T$	no description

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[250-355]T$	no description

noIPR
unintegrated

unintegrated
PTHR10169	$\"[30-645]T$	DNA TOPOISOMERASE/GYRASE
PTHR10169:SF3	$\"[30-645]T$	DNA GYRASE SUBUNIT B

","BeTs to 14 clades of COG0187COG name: DNA gyrase (topoisomerase II) B subunitFunctional Class: LThe phylogenetic pattern of COG0187 is a---yqvCEBrHujGPOlINXNumber of proteins in this genome belonging to this COG is 2","***** IPB001241 (DNA topoisomerase II family) with a combined E-value of 1.4e-137. IPB001241A 16-37 IPB001241B 113-131 IPB001241C 171-183 IPB001241D 275-288 IPB001241E 323-349 IPB001241F 430-478 IPB001241G 498-524 IPB001241H 580-603","Residues 419-486 are 94% similar to a (TOPOISOMERASE ATP-BINDING DNA SUBUNIT GYRASE DNA-BINDING) protein domain (PD000714) which is seen in PARE_STRPN.Residues 138-193 are 55% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA) protein domain (PD242130) which is seen in PARE_BACSU.Residues 488-567 are 87% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA GYRASE PROTEOME IV) protein domain (PD000616) which is seen in PARE_STRPN.Residues 40-136 are 64% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING GYRASE) protein domain (PD404171) which is seen in PARE_BACSU.Residues 195-241 are 57% similar to a (TOPOISOMERASE B ATP-BINDING SUBUNIT) protein domain (PD402782) which is seen in PARE_BACSU.Residues 11-36 are identical to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA) protein domain (PD372606) which is seen in PARE_STRPN.Residues 574-636 are 95% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA) protein domain (PD149633) which is seen in PARE_STRPN.Residues 500-595 are 31% similar to a (TOPOISOMERASE II DNA-BINDING ATP-BINDING NUCLEAR ISOZYME) protein domain (PD335861) which is seen in O62199_CAEEL.Residues 244-367 are 82% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA GYRASE PROTEOME IV) protein domain (PD001260) which is seen in Q9CGW3_LACLA.Residues 40-238 are 79% similar to a (TOPOISOMERASE ATP-BINDING DNA SUBUNIT GYRASE II) protein domain (PD000740) which is seen in PARE_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 13:45:38 2006","Thu Aug 10 08:40:08 2006","Thu Aug 10 08:40:08 2006","Tue Feb 26 08:15:14 2002","Tue Feb 26 08:15:14 2002","Tue Feb 26 08:15:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1106 is paralogously related (blast p-value < 1e-3) to SMu1167, a predicted DNA gyrase subunit B.","Tue Feb 26 08:21:03 2002","Thu Aug 10 08:40:08 2006","pdb1EI1A Chain A, Dimerization Of E. Coli Dna Gyrase B Provid... 301 2e-082pdb1AJ6 Novobiocin-Resistant Mutant (R136h) Of The N-Termi... 185 2e-047pdb1BJT Topoisomerase Ii Residues 409 - 1201 >gi1633273p... 72 2e-013","SMU.1210c","","Residues 36 to 181 (E-value = 1.5e-30) place SMu1106 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)Residues 229 to 400 (E-value = 1.6e-89) place SMu1106 in the DNA_gyraseB family which is described as DNA gyrase B (PF00204)Residues 429 to 540 (E-value = 5.5e-06) place SMu1106 in the Toprim family which is described as Toprim domain (PF01751)Residues 571 to 636 (E-value = 8.8e-45) place SMu1106 in the DNA_gyraseB_C family which is described as DNA gyrase B subunit, carboxyl terminus (PF00986)","Thu Aug 10 08:40:08 2006","","","","Pan,X.S. and Fisher,L.M.Cloning and characterization of the parC and parE genes ofStreptococcus pneumoniae encoding DNA topoisomerase IV: role influoroquinolone resistanceJ. Bacteriol. 178 (14), 4060-4069 (1996)PubMed: 8763932Munoz,R. and De La Campa,A.G.ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotypeAntimicrob. Agents Chemother. 40 (10), 2252-2257 (1996)PubMed: 8891124","","Tue Feb 26 08:17:04 2002","1","","","SMU.1210c","130" "SMu1107","1153161","1153799","639","ATGAAACTAATTCTTTTGATAATTGCAGCCTATCTTCTAGGATCTATACCGACAGGACTTTGGATTGGCAAATATTTTTACGGTAAAAATTTACGAGACTATGGCAGCGGCAATATGGGAACCACTAATACTTTTCGTGTCTTAGGCCCAAAAGCTGGGTTATTAACGTTTACAGTTGACTTTTTAAAGGGAACGCTGGCAACTCTGCTGCCCATGTGGTTAGGAGTAACCCATATTTCTCCCTTGCTGTTTGGTTTTTTTGCTATTTTAGGACACACTTTCCCTATTTTTGCTAATTTTAAGGGTGGTAAGGCTGTGGCAACTTCAGCAGGTATTTTGTTAGGTTTTGCTCCTTTCTATCTTATTTTCCTTTTGTTCATTTTCTTCTTTACTCTTTATCTAACCAGCATGATTTCCTTATCAAGTGTCATTGCTGCCAGTATTGCTATTATTACCGTATTGATTTTTCCTGCTCTACACTTTCTTTTAAAAGACTATGATTTTCTGTTTGTCTTAATTGTTATTTCAGCAGGCAGTTTGATTATCATACGCCATCGTGAAAATTTGGTACGTATTAAAAATAAAACCGAAAGTTTAGTTCCTTTTGGTCTCAATATTACTAAACAAAAAACACATTAA","10.90","12.18","23402","MKLILLIIAAYLLGSIPTGLWIGKYFYGKNLRDYGSGNMGTTNTFRVLGPKAGLLTFTVDFLKGTLATLLPMWLGVTHISPLLFGFFAILGHTFPIFANFKGGKAVATSAGILLGFAPFYLIFLLFIFFFTLYLTSMISLSSVIAASIAIITVLIFPALHFLLKDYDFLFVLIVISAGSLIIIRHRENLVRIKNKTESLVPFGLNITKQKTH","1153808","","conserved hypothetical protein","Membrane, Cytoplasm","Several matches in gapped BLAST to hypotheticals and conserved hypothetical proteins:residues 14-209 are 54% similar to a hypothetical from S.pneumoniae (gi|6137269|) and residues 1-209 are 53% similar to gi|15674929| from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1155 (2e-61).","

InterPro
IPR003811
Family

Protein of unknown function DUF205
PF02660	$\"[7-195]T$	DUF205
TIGR00023	$\"[1-203]T$	DUF205

","BeTs to 7 clades of COG0344COG name: Predicted membrane protein, YgiH/UPF0078 familyFunctional Class: SThe phylogenetic pattern of COG0344 is -----qVceb-hujgp-----Number of proteins in this genome belonging to this COG is 1","***** IPB003811 (DUF205) with a combined E-value of 7e-47. IPB003811A 6-19 IPB003811B 30-66 IPB003811C 90-111 IPB003811D 180-200","Residues 156-209 are 61% similar to a (PROTEOME 5'REGION COMPLETE YKAC) protein domain (PD265034) which is seen in YPAE_STRPN.Residues 14-118 are 68% similar to a (PROTEOME COMPLETE TRANSMEMBRANE MG247) protein domain (PD007519) which is seen in YPAE_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 08:26:08 2002","Tue Feb 26 08:26:08 2002","Tue Feb 26 08:26:08 2002","Tue Feb 26 08:26:08 2002","Tue Feb 26 08:26:08 2002","Tue Feb 26 08:26:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1107 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 08:26:08 2002","","No significant hits to the NCBI PDB database.","SMU.1211","","Residues 7 to 195 (E-value = 3.2e-53) place SMu1107 in the DUF205 family which is described as Domain of unknown function DUF (PF02660)","Tue Feb 26 08:26:08 2002","24379636","","","","","","1","","","SMU.1211","685" "SMu1108","1156100","1153986","2115","ATGATGAAAAAGAAAGCAATTATTATACCGGTCTTATCAACTTTGCTTTTATCTGGTGCTATTTTAACAGCACACGTTTATGCAGACGATTTAACGACGGAACCATCTGCTGATAGCAGTACTCAATCAAGCAGTCTTTCCTTTTCTGAACAGACGGCTGACTCAGGACAAGAGACTAGTCAGGTCTCTGATGCAATTTCTTCTGTTGCAGCAGTAAAATCTGCTGATGATTCCAAATCAGTTTTTGAAGATAGTCATTCTGATGAAGTCTCATCATCTTCAGCAAGCAGCGGCCCTAAACCTGCTGTTAATTGCGTATCAGATGAAGCAACAACCACCATTCTCCACACCAATGATATGCATGGGCGTTTCTTAGAAGATAGCAGCAATGGTGTTATTGGCATGCCAAAATTAGCAGGAATTGCAGCTGAATCCAGAAAAAAAGGGACTACCTTGCTATTGGATTCCGGAGATGCTATCCAAGGTCTGCCAATTACCAATAACAGTAAGGGAGAAGATGCAGTAGCTCTCATGAATGCTACGGGTTATGATGCCATGACGGTGGGCAATCATGAATTTGATTTTGGCTTAGATCAATTAAAGACTTTGGTCAAGAAACTTGATTTTCCAATTATCAGTTCTAATATTTATGTCAATGGCGTCCGTCTTTTTCAAGCTTCTACAGTTATTGACAAAAATAAAAACATTGATGGGGATGAATATGTTGTTATTGGTGTCACGACACCTGAAACAGCCACTAAAACCCATCCGCGCAATGTTCTGGGTGTGACTTTTACTGATCCGATTACTGAGGTTAACAATGTTATTGCTCAAACCGAAGCACAGGCTAGATCGCAAGGAAAGACTTATAAAAATTATATTATTTTGGGACATCTAGGGGTAGATACAACAACCAAGGAAGAATGGCGCGGAGACAGCCTCGCTCAAGCACTGGCTAAGAATAGTCTGCTGGCTGGTAAAAATGTCATTGTACTTGATGGTCATTCGCATACAGCTAAAACGCAAACCTATGGCAATGTGACCTATAATCAAACAGGAAGTTATCTCAATAATGTTGGTCTGATTAAGCTCAATTCCAAGGAGATCCTAAGCAATGCGTTGATTTCTGATCAGGATGCCAAGACAGTAGCAGCTGACCCCAATGTGCAGATGATGGTTGATCAGATTGAGACTAAGTATAAAGCTGACAGTTCTACCATTTTAATTGCCAATAGTCCAGTTGAACTCAATGGCGATCGCATGAATGTGCGTGTTCGTGAGACAAATCTGGGGAATGCAGTGGCAGATGCCTTGCTTGATTATGGACAAACGGGCTTTTCACATAAGTCCAATTTAGCTGTTACTAATGGCGGTGGTCTTCGTGAAACAATTGCCAAGGATAAGCCTATTACCAAAGGAGATATTATTGCTGTTTTGCCTTTTGGTAATAGCGTTGCGCAAGTCGCCGCGACAGGGCAGAATATCAAAGATATGTTTACCAAATCTCTAGGTTCTATTTTACAAGCAGATGATAAAGGCAAGTCTGTTCTTGACGAAAATGGTCAGCCATTGCTTGAGCCAAGCGGCGGTTTCTTACAAATTGCTGGTGCTAAGGTTTACTATGATACTAGCCTAGAACCGAGAAAACGTATCCTTTATATTGCAATTTTAGACCCAGAAACAAAGACCTATCAGCCTCTGGATTTGACAAAAATTTACTATCTCGTCACGAATGACTTTTTAGCAGCAGGCGGTGATGGCTATACCATGTTGGGAGGTAGCCGCGAAGAAGGTCCATCTATGGACAGTATCTTCACTGATTATCTATCTCGTGCTGATTTGACGCAATATCGAGTGATTAACCCTAATTCGCGTAGCATTTCCATATCATCAACCAAGGACTCAGATGGTGATGGACAGCCTGATTATTTGCAATTAATTGCTGATAACAAGGCCACTGTTCCTCAAAAGGGGTTTGACTCTGGTCAAGACAAGTCAGAAGTTATTACCTTGTCTTATTCAAAAAATTGGAGAGCAGACCAATCCTTACTAATCTCTGCTCTTCATCAGACAGCTCCATTAGCAGAAAAATTTTCTTCCTATCAGGAAAAATAA","4.80","-20.34","75446","MMKKKAIIIPVLSTLLLSGAILTAHVYADDLTTEPSADSSTQSSSLSFSEQTADSGQETSQVSDAISSVAAVKSADDSKSVFEDSHSDEVSSSSASSGPKPAVNCVSDEATTTILHTNDMHGRFLEDSSNGVIGMPKLAGIAAESRKKGTTLLLDSGDAIQGLPITNNSKGEDAVALMNATGYDAMTVGNHEFDFGLDQLKTLVKKLDFPIISSNIYVNGVRLFQASTVIDKNKNIDGDEYVVIGVTTPETATKTHPRNVLGVTFTDPITEVNNVIAQTEAQARSQGKTYKNYIILGHLGVDTTTKEEWRGDSLAQALAKNSLLAGKNVIVLDGHSHTAKTQTYGNVTYNQTGSYLNNVGLIKLNSKEILSNALISDQDAKTVAADPNVQMMVDQIETKYKADSSTILIANSPVELNGDRMNVRVRETNLGNAVADALLDYGQTGFSHKSNLAVTNGGGLRETIAKDKPITKGDIIAVLPFGNSVAQVAATGQNIKDMFTKSLGSILQADDKGKSVLDENGQPLLEPSGGFLQIAGAKVYYDTSLEPRKRILYIAILDPETKTYQPLDLTKIYYLVTNDFLAAGGDGYTMLGGSREEGPSMDSIFTDYLSRADLTQYRVINPNSRSISISSTKDSDGDGQPDYLQLIADNKATVPQKGFDSGQDKSEVITLSYSKNWRADQSLLISALHQTAPLAEKFSSYQEK","1154001","","5'-nucleotidase/2',3'-cyclic-nucleotide 2'-phosphodiesterase","Periplasm, Membrane, Cellwall, Extracellular","Limited matches in gapped BLAST to hypotheticals and to nucleotidase precursor:residues 106-657 are 41% similar to hypothetical protein from S.aureus (gi15925728).Residues 113-591 are 34% similar to nucleotidase precursor from B.halodurans (gi15612589).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1941 (5e-20).","

InterPro
IPR004843
Domain

Metallophosphoesterase
PF00149	$\"[112-339]T$	Metallophos

InterPro
IPR006146
Domain

5'-Nucleotidase, N-terminal
PS00786	$\"[183-194]T$	5_NUCLEOTIDASE_2

InterPro
IPR006179
Family

5'-Nucleotidase and apyrase
PR01607	$\"[110-128]T$ $\"[321-344]T$ $\"[469-492]T$ $\"[566-585]T$	APYRASEFAMLY
PTHR11575	$\"[113-506]T$ $\"[523-613]T$	5_nucleotidase

InterPro
IPR008334
Domain

5'-Nucleotidase, C-terminal
G3DSA:3.90.780.10	$\"[408-629]T$	5'-Nucleotdase_C
PF02872	$\"[408-593]T$	5_nucleotid_C
SSF55816	$\"[408-626]T$	5'-Nucleotdase_C

InterPro
IPR014579
Family

Predicted 5'-nucleotidase, SA0022 type
PIRSF033095	$\"[2-704]T$	5NTD_SA0022

noIPR
unintegrated

unintegrated
G3DSA:3.60.21.10	$\"[107-402]T$	G3DSA:3.60.21.10
SSF56300	$\"[108-402]T$	SSF56300

","BeTs to 9 clades of COG0737COG name: 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterasesFunctional Class: FThe phylogenetic pattern of COG0737 is a-t-yqvCEB-Huj---l---Number of proteins in this genome belonging to this COG is 3","***** IPB002224 (5'-Nucleotidase) with a combined E-value of 2.7e-52. IPB002224A 110-128 IPB002224B 150-158 IPB002224C 181-200 IPB002224D 207-216 IPB002224E 328-337 IPB002224F 416-431 IPB002224G 453-464 IPB002224H 468-484 IPB002224I 565-588","Residues 113-185 are 47% similar to a (PROTEOME COMPLETE NUCLEOTIDASE PRECURSOR) protein domain (PD314073) which is seen in Q9KGN2_BACHD.Residues 409-590 are 32% similar to a (HYDROLASE PRECURSOR COMPLETE PROTEOME) protein domain (PD302725) which is seen in O34313_BACSU.Residues 186-314 are 30% similar to a (HYDROLASE COMPLETE PROTEOME PRECURSOR SIGNAL UDP-SUGAR) protein domain (PD002576) which is seen in Q9KGN2_BACHD.Residues 175-364 are 28% similar to a (PROTEOME COMPLETE HYDROLASE) protein domain (PD267733) which is seen in Q9KE43_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 08:34:44 2002","Tue Mar 13 13:40:59 2007","Tue Mar 13 13:40:59 2007","Tue Mar 13 13:40:59 2007","Tue Mar 13 13:40:59 2007","Tue Feb 26 08:31:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1108 is paralogously related (blast p-value < 1e-3) to SMu0471, a predicted conserved hypothetical protein.","Tue Feb 26 08:34:44 2002","Tue Mar 13 13:40:59 2007","pdb2USHB Chain B, 5'-Nucleotidase From E. Coli >gi5542500pd... 131 3e-031","SMU.1213c","","Residues 112 to 339 (E-value = 3.2e-10) place SMu1108 in the Metallophos family which is described as Calcineurin-like phosphoesterase (PF00149)Residues 408 to 593 (E-value = 9.2e-49) place SMu1108 in the 5_nucleotid_C family which is described as 5'-nucleotidase, C-terminal domain (PF02872)","Tue Mar 13 13:40:59 2007","24379637","","","","","","1","","","SMU.1213c","" "SMu1109","1157554","1156286","1269","ATGTTACTTATAAAAAATGGCCGTGTTCTTGATCCTAAGTCTGGTCTTGATCGGGTATTAGATGTTTTGCTTGATGGTAAAAAGGTCGTCAAGATTGCAGAAAATATTGAGTCTGTGGATGCTCAGGTTATCGATGCAGAAGGTCTTGTTGTAGCACCTGGTTTGGTTGATGTTCATGTTCATTTTCGTGAACCTGGCCAAACCCATAAGGAAGATATTCATACAGGAGCTTTGGCAGCAGCAGCTGGCGGAGTAACGACAGTTGTTATGATGGCTAATACCACACCGACTATTTCTGATGTGGCAACTCTGACAGAAGTTTTAGAAAGTGCCGCTAAAGAAAATATTCATATTAAAACAGTAGCTACCATTACGAAGCATTTTGATGGTCAGCATTTGACTGATTTTGAAACACTTTTAAAAGCAGGAGCAGTTGGATTTTCGGATGATGGCATTCCTTTGACAAGTTCTAAGGTTGTCAAGGAAGCTCTGGATTTGGCCAAGAAGAATGACACTTTTATTAGTCTGCATGAAGAAGATCCAGAGTTAAATGGCATTTTAGGTTTTAATGAAAAAATTGCCAAAGAACATTTTAAAATCTGTGGAGCAACAGGTGTTGCAGAATACAGTATGATTGCGCGTGATGTCATGATTGCTTACGATAGGCAGGCTCATATCCATATTCAGCATTTATCTAAGGCAGAGTCTGTCAAAGTGGTTGCATTTGCACAAAAATTAGGCGCTCAAGTAACAGCAGAAGCAGCACCGCAGCATTTTTCCAAAACAGAAAATCTTTTGTTGGAAAAGGGAGCCAATGCTAAGATGAATCCTCCTCTTCGTTTGGAGGCGGATCGTCTGGCTGTGATTGAAGGGCTCAAGTCAGGTGTTATTTCTGTCATCGCAACAGACCACGCTCCCCATCATGCGGATGAAAAAAATGTAGCAGATGTGACTAAGGCGCCATCAGGAATGACGGGCTTGGAAACTTCTTTATCATTAGGCTTGACTTATTTAGTAGAAGCAGGACATCTTAGTTTGATGGACTTCTTAGCCAAAATGACCATCAATCCAGCACAGCTTTATGATTTTGATGTTGGCTATTTAGCAGAAAATGGTCCTGCTGATCTTGTGATATTTGCGGATAAGGAGGACCGTCTGGTTTCTAATCATTTTGCCTCTAAGGCCGCCAATTCACCCTTTATTGGTGAAACCTTAAAGGGTCAAGTCAAATATACCATCTGTTCTGGTGAAGTGATTTATCAAGCATAA","5.60","-13.73","45221","MLLIKNGRVLDPKSGLDRVLDVLLDGKKVVKIAENIESVDAQVIDAEGLVVAPGLVDVHVHFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTTPTISDVATLTEVLESAAKENIHIKTVATITKHFDGQHLTDFETLLKAGAVGFSDDGIPLTSSKVVKEALDLAKKNDTFISLHEEDPELNGILGFNEKIAKEHFKICGATGVAEYSMIARDVMIAYDRQAHIHIQHLSKAESVKVVAFAQKLGAQVTAEAAPQHFSKTENLLLEKGANAKMNPPLRLEADRLAVIEGLKSGVISVIATDHAPHHADEKNVADVTKAPSGMTGLETSLSLGLTYLVEAGHLSLMDFLAKMTINPAQLYDFDVGYLAENGPADLVIFADKEDRLVSNHFASKAANSPFIGETLKGQVKYTICSGEVIYQA","1156301","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0782 (pyrB); SMu0783 (pyrA); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH).","dihydroorotase","Cytoplasm, Extracellular","Several matches in gapped BLAST to dihydroorotase: residues 1-422 are 68% similar to the enzyme in S.pneumoniae (gi|15901032|). Residues 1-420 are 67% similar to the protein from S.pyogenes (gi|15674928|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1045 (1e-138).","

InterPro
IPR002195
Domain

Dihydroorotase
PS00482	$\"[57-65]T$	DIHYDROOROTASE_1
PS00483	$\"[301-312]T$	DIHYDROOROTASE_2

InterPro
IPR004722
Domain

Dihydroorotase multifunctional complex type
TIGR00857	$\"[15-422]T$	pyrC_multi

InterPro
IPR006680
Domain

Amidohydrolase 1
PF01979	$\"[50-380]T$	Amidohydro_1

InterPro
IPR011059
Domain

Metal-dependent hydrolase, composite
SSF51338	$\"[2-418]T$	Metalo_hydrolase

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.140	$\"[54-406]T$	G3DSA:3.20.20.140
PTHR11647	$\"[43-421]T$	PTHR11647
PTHR11647:SF2	$\"[43-421]T$	PTHR11647:SF2
SSF51556	$\"[54-369]T$	SSF51556

","BeTs to 12 clades of COG0044COG name: DihydroorotaseFunctional Class: FThe phylogenetic pattern of COG0044 is amtkYqvcEBr-uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002195 (Dihydroorotase) with a combined E-value of 1.7e-26. IPB002195A 56-66 IPB002195B 75-100 IPB002195C 250-261 IPB002195D 297-308","Residues 218-418 are 56% similar to a (DIHYDROOROTASE PYRIMIDINE BIOSYNTHESIS HYDROLASE ZINC) protein domain (PD001085) which is seen in Q9CGM7_LACLA.Residues 2-74 are 56% similar to a (HYDROLASE UREASE AMIDOHYDROLASE METAL-BINDING NICKEL) protein domain (PD000518) which is seen in Q9CGM7_LACLA.Residues 93-217 are 55% similar to a (PROTEOME COMPLETE DIHYDROOROTASE) protein domain (PD397171) which is seen in Q9CGM7_LACLA.Residues 42-421 are 21% similar to a (PROTEOME COMPLETE DIHYDROOROTASE) protein domain (PD286905) which is seen in Q9PNA0_CAMJE.Residues 272-409 are 29% similar to a (CARBAMOYLTRANSFERASE CHAIN NON-CATALYTIC) protein domain (PD399336) which is seen in PYRX_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 15:54:56 2002","Tue Feb 26 08:38:52 2002","Thu Oct 17 11:59:03 2002","Tue Feb 26 08:38:52 2002","Tue Feb 26 08:38:52 2002","Tue Feb 26 08:38:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1109 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 08:43:30 2002","","No significant hits to the NCBI PDB database.","SMU.1214c","","Residues 50 to 380 (E-value = 4.2e-21) place SMu1109 in the Amidohydro_1 family which is described as Amidohydrolase family (PF01979)","Tue Feb 26 08:38:52 2002","","","","Ghim,S.Y., Nielsen,P. and Neuhard,J.Molecular characterization of pyrimidine biosynthesis genes fromthe thermophile Bacillus caldolyticusMicrobiology 140 (Pt 3), 479-491 (1994)PubMed: 7516791Quinn,C.L., Stephenson,B.T. and Switzer,R.L.Functional organization and nucleotide sequence of the Bacillussubtilis pyrimidine biosynthetic operonJ. Biol. Chem. 266 (14), 9113-9127 (1991)PubMed: 1709162","","Tue Feb 26 08:43:30 2002","1","","","SMU.1214c","362" "SMu1110","1158217","1157564","654","ATGGAACATTCAGCTTGGCATGATTTGATTAAGAAAGAACTTCCAGAAGGCTATTTTGCTCAGATTAATCATTTTATGAATGAAGTGTATGCGCAAGGTGTTATTTATCCACCTAGAGATAAGGTCTTTAATGCCATTCAGACCACACCTTTGGATAAGGTTAAGGTTGTTATTATTGGTCAGGATCCTTATCACGGACCCAATCAGGCACAGGGATTATCTTTTTCTGTACCTGATCAAGTGCCTGCTCCGCCATCTCTCCAAAATATTTTAAAGGAACTGGCAGATGATATTGGACAAAAACAAAGTCATGATTTGACCTCTTGGGCCAAGCAAGGTGTGCTTTTGTTAAATGCTAGCTTAACGGTTCCTGAACATCAGGCTAATGCTCATGCCAATGGTATCTGGGAACCTTTTACGGATGCCGTTATTAAGGTTGTTAATCAAAAAGAGACACCGGTTGTCTTTATTCTTTGGGGTGGTTTTGCACGTAAGAAAAAGGCACTTATTACCAATTCCATTCACCATATTATTGAATCGCCCCATCCTAGCCCCTTGTCTGCTCACCGAGGATTTTTTGGCAGTAAACCTTTCTCACAGACAAATCATTTTTTAGTGGCACAAGGTTTAGAACCCATTGATTGGCTTAAATAA","7.20","0.88","24197","MEHSAWHDLIKKELPEGYFAQINHFMNEVYAQGVIYPPRDKVFNAIQTTPLDKVKVVIIGQDPYHGPNQAQGLSFSVPDQVPAPPSLQNILKELADDIGQKQSHDLTSWAKQGVLLLNASLTVPEHQANAHANGIWEPFTDAVIKVVNQKETPVVFILWGGFARKKKALITNSIHHIIESPHPSPLSAHRGFFGSKPFSQTNHFLVAQGLEPIDWLK","1157579","From Genbank:[gi:137041]This enzyme excises uracil residues from the DNA which can arise as a result of misincorporation of dump residues by DNA polymerase or deamination of cytosine.","uracil-DNA glycosylase","Periplasm, Cytoplasm","Several matches in gapped BLAST to uracil DNA glycosylase:residues 1-216 are 79% similar to the enzyme in S.agalactiae (gi|8134775|). Residues 1-217 are 73% similar to the protein from S.pneumoniae (gi|15903099|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1156 (1e-104).","

InterPro
IPR002043
Family

Uracil-DNA glycosylase
PTHR11264	$\"[19-217]T$	UDNA_glycsylse
TIGR00628	$\"[3-210]T$	ung
PS00130	$\"[55-64]T$	U_DNA_GLYCOSYLASE

InterPro
IPR003249
Family

Uracil-DNA glycosylase, not poxvirus
PD001589	$\"[5-215]T$	U_glycsylse_notp

InterPro
IPR005122
Family

Uracil-DNA glycosylase superfamily
PF03167	$\"[47-206]T$	UDG

noIPR
unintegrated

unintegrated
G3DSA:3.40.470.10	$\"[3-215]T$	G3DSA:3.40.470.10
SSF52141	$\"[4-215]T$	UDNA_glycsylseSF

","BeTs to 8 clades of COG0692COG name: Uracil DNA glycosylaseFunctional Class: LThe phylogenetic pattern of COG0692 is ----y---ebrhujgpo-in-Number of proteins in this genome belonging to this COG is 1","***** IPB002043 (Uracil-DNA glycosylase) with a combined E-value of 2.7e-66. IPB002043A 53-77 IPB002043B 104-137 IPB002043C 155-165 IPB002043D 175-187 IPB002043E 192-215","Residues 1-34 are 67% similar to a (UDG 3.2.2.- GLYCOSYLASE URACIL-DNA) protein domain (PD409200) which is seen in UNG_STRPN.Residues 35-215 are 83% similar to a (GLYCOSYLASE URACIL-DNA GLYCOSIDASE) protein domain (PD001589) which is seen in UNG_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 08:51:03 2002","Tue Feb 26 08:47:51 2002","Thu Oct 17 11:59:45 2002","Tue Feb 26 08:47:17 2002","Tue Feb 26 08:47:17 2002","Tue Feb 26 08:47:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1110 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 08:47:17 2002","Tue Feb 26 08:47:17 2002","pdb|1EMH|A Chain A, Crystal Structure Of Human Uracil-Dna Glyco... 219 3e-058pdb|2SSP|E Chain E, Leucine-272-Alanine Uracil-Dna Glycosylase ... 217 1e-057pdb|4SKN|E Chain E, A Nucleotide-Flipping Mechanism From The St... 214 7e-057","SMU.1215c","","Residues 49 to 206 (E-value = 3.3e-71) place SMu1110 in the UDG family which is described as Uracil DNA glycosylase superfamily (PF03167)","Tue Feb 26 08:47:17 2002","","","","Mejean,V., Rives,I. and Claverys,J.P.Nucleotide sequence of the Streptococcus pneumoniae ung geneencoding uracil-DNA glycosylaseNucleic Acids Res. 18 (22), 6693 (1990)PubMed: 2251133","","Tue Feb 26 08:51:03 2002","1","","","SMU.1215c","570" "SMu1111","1158893","1158240","654","ATGTTTATTAATTTTCATCTGATCATCAAAAGTTTATCCTTTGTTTTGACAGGCATTCCATATACCTTAGGTATTTCAGTTCTTAGTTTTCTGACAGGCTGCCTCTTGGGAATCTTTATTTCTTTCTTGAGGATGTCTCAGAATTCTTGGCTTAGGTCCTTGGCGCGGATATATATTTCTATCATGCGTGGTGTTCCCATGCTTGTCGTTTTATTTGTCCTTTATTTTGGTCTGCCTTATTTTGAGGTGCAGCTGCCTGCCTTGCTTTGTGCCTATATTGGTTTTAGCGCAGTCAGTTCAGCCTACATATCTGAAATATTTCGAGCTTCTATCTCAGCAGTAGATAAAGGACAATGGGAAGCAGCAGGGGCTCTTGGTTTGCCTATGACATCCATTTTAAAAAGTATTATTTTACCGCAGGCTTTTCGGATTGCTATTGCGCCTTTGGGAAATGTTATGTTGGATATGCTCAAAAGCTCTTCATTAGCGGCTATGATTACAGTACCGGATATTTTTCAAAATGCGAAAATTATCGGTGGCCGCGAGTATGATTACATGTCTATGTATATTTTGATTGCTTTTATTTATTGGCTTCTTTGTTTTTTGTTTGAAATGTTTCAAAATCATTTGGAAGCAAAACTCAGTGTTTATTGA","8.80","3.32","24295","MFINFHLIIKSLSFVLTGIPYTLGISVLSFLTGCLLGIFISFLRMSQNSWLRSLARIYISIMRGVPMLVVLFVLYFGLPYFEVQLPALLCAYIGFSAVSSAYISEIFRASISAVDKGQWEAAGALGLPMTSILKSIILPQAFRIAIAPLGNVMLDMLKSSSLAAMITVPDIFQNAKIIGGREYDYMSMYILIAFIYWLLCFLFEMFQNHLEAKLSVY","1158255","For other components see SMu1112 (SBP1)","ABC transporter, amino acid permease","Membrane, Cytoplasm","Matches in gapped BLAST to ABC permeases. Residues 3-216 are 70% similar to gi|15674926| from S.pyogenes. Residues 4-217 are 56% similar to gi|16077406| from B.subtilis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1609 (4e-65).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[15-216]T$	BPD_transp_1
PS50928	$\"[19-207]T$	ABC_TM1

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[11-109]T$	HEQRo_perm_3TM

","BeTs to 7 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 144-200 are 70% similar to a (TRANSPORT PERMEASE ABC TRANSPORTER) protein domain (PD006016) which is seen in YCKA_BACSU.Residues 14-80 are 56% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC COMPLETE) protein domain (PD001196) which is seen in YCKA_BACSU.Residues 83-140 are 53% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in YCKA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 13:56:01 2002","Tue Feb 26 09:07:38 2002","Thu Oct 17 13:56:01 2002","Tue Feb 26 09:07:38 2002","","Tue Feb 26 09:07:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1111 is paralogously related (blast p-value < 1e-3) to SMu0732, SMu0417, SMu1382, SMu0219, SMu0848, SMu1080, SMu0847, SMu1383, and SMu0516, all ABC permeases.","Thu Apr 25 17:49:50 2002","","No significant hits to the NCBI PDB database.","SMU.1216c","","Residues 15 to 216 (E-value = 1.8e-26) place SMu1111 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Tue Feb 26 09:07:38 2002","24379640","","","","","","1","","","SMU.1216c","" "SMu1112","1159894","1159043","852","ATGAAAAAGCATTTTTTCATGACTTTTAGCCTCTTGCTAGCGGCTGTTTTTCTAGTTGCTTGTTCCAATCTTTCCGATTCTGGACAGAGGAATTGGGATAAGATAAATAAGAGAGGAATGCTTAAAATTGCTACTGCAGGAACGCTTTATCCGCAATCTTATCATGATGATCATAATAAATTGACGGGTTATGATGTTGAAATTCTAAAAGAAATAGGAAAACGTTTGGGATTGAAAGTTCAGTTTACTGAAATGGGTGTCGATGGTATGCTGACAGCCATCAAGAGCGGTCAGATCGATGTTGCTAATTATTCCCTAGAAGACGGCAACAAAAATATCAGTAAGTTTTTGAGAACCTCTCCCTATAAATATTCTTTTACGTCAATGGTTGTCCGCTCTAAAGATGATTCAGGTATTCATTCTTGGTCAGACCTTAAGGGAAAAAAAGCTGCCGGAGCTGCCAGCACTAATTATATGAAGATTGCTAAAAAATTAGGAGCAAAATTAGTTGTCTATGATAATGTCACCAACGATGTTTATATGAAAGATTTAGTTAATGGTCGTACAGATGTCATTATCAATGATTATTATCTGCAAAAGATAGCTGTTGCAGCAGTCAAAGACAAATACGCTATCAAAATAAACCAAGGACTTTATGCCAATCCTTACAGCACTAGTTTTACATTGTCTTTGAAAAACAAAGTACTGCAAAAGAAAATCAATAAGGCTGTGAAAGACATGCGCAAGGATGGCACCCTAACCAAGCTATCTAAGAAGTTTTTCCAAGGAGAAGACGTCACTAAAAAACATTATAATAGCTATAAAAAAATTGATATTTCTGACGTTGATTAA","10.50","20.15","31844","MKKHFFMTFSLLLAAVFLVACSNLSDSGQRNWDKINKRGMLKIATAGTLYPQSYHDDHNKLTGYDVEILKEIGKRLGLKVQFTEMGVDGMLTAIKSGQIDVANYSLEDGNKNISKFLRTSPYKYSFTSMVVRSKDDSGIHSWSDLKGKKAAGAASTNYMKIAKKLGAKLVVYDNVTNDVYMKDLVNGRTDVIINDYYLQKIAVAAVKDKYAIKINQGLYANPYSTSFTLSLKNKVLQKKINKAVKDMRKDGTLTKLSKKFFQGEDVTKKHYNSYKKIDISDVD","1159058","For other components see SMu1111 (MSD1) and (SBP2).For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762(atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE). ","amino acid ABC transporter, substrate binding protein","Membrane, Periplasm, Extracellular","Matches in gapped BLAST to amino acid ABC transporters. Residues 23-283 are 51% similar to gi16077407 from B.subtilis.Residues 43-269 are 29% similar to the previously sequenced AtmA gene from S.mutans (see Smu 1765). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1610 (1e-65).","

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[41-263]T$	SBP_bac_3
SM00062	$\"[40-264]T$	PBPb
PS01039	$\"[63-76]?$	SBP_BACTERIAL_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[36-174]T$	G3DSA:3.40.190.10
PS51257	$\"[1-21]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[1-268]T$	SSF53850

","BeTs to 10 clades of COG0834COG name: Periplasmic amino acid binding proteinsFunctional Class: EThe phylogenetic pattern of COG0834 is A-----VCEBrHUJ---LINxNumber of proteins in this genome belonging to this COG is 8","No significant hits to the Blocks database.","Residues 39-147 are 52% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT ABC TRANSPORTER) protein domain (PD245531) which is seen in YCKB_BACSU.Residues 172-266 are 52% similar to a (AMINO TRANSPORTER ABC PERIPLASMIC) protein domain (PD090480) which is seen in Q9R7U7_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 09:57:10 2006","Tue Sep 19 09:57:10 2006","Tue Sep 19 09:57:10 2006","Tue Feb 26 09:13:18 2002","","Tue Feb 26 09:13:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1112 is paralogously related (blast p-value < 1e-3) to SMu1078, SMu0739, SMu0846, SMu0732, SMu1765, SMu0416, SMu0741, SMu1381, SMu0219, and SMu0593, all involved in ABC transport. ","Tue Feb 26 09:15:45 2002","Tue Sep 19 09:57:10 2006","pdb1HSLA Chain A, Histidine-Binding Protein Complexed With L-... 72 7e-014","SMU.1217c","","Residues 41 to 263 (E-value = 1e-49) place SMu1112 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)","Tue Feb 26 09:13:18 2002","24379641","","","","","","1","","","SMU.1217c","965" "SMu1113","1161451","1160009","1443","ATGCAATTTCCAGATGCAACAGCTATGGCCAATGCAGTGAAGCAAAAAGATGTTTCTCCTAGAGAACTAGTAAAATGGACGATTGAAAAAGCTGAAAAGCATAATCCTTCCTTAAATGCTATCGTCAGTCAACGCTATGAAAGAGCTTTGCAAGAAGCGCGGGAACGCGATTTCACAGGAAAACCTTTTGCAGGTGTTCCTCTCTTTCTCAAAGATTTAGGACAGGAACAGGCTGGGGAATTATCAACATCAGGCTCTCGTCTACTGGCTAATTATCATGCCAGTCATTCTGACAACTATGTCAAAAGCTTAGAAGCCTTGGGTTTTATTATTCTTGGTCGCACCAATACACCAGAGTTTGGTTTTAAGAATATTAGTGACTCTAGTTTGCATGGTCAGGTCAATTTGCCTGATGATGTCAGCCGCAATGCGGGTGGCTCCAGTGGTGGCGCCGCAGCCTTGGTTAGCTCAGGTGTTGTGCCTTTAGCGGCTGCCAGCGATGGTGGTGGCTCCATTCGGATTCCTACTTCTTTTAATGGTCTTATTGGTCTGAAACCAACACGTGGTCGCATTCCAGTTGGCCCCACTTCTTTTAGAGGCTGGCAGGGCGCCTCTGTTCAGTTTGCCCTGACCAAGACGGTGCGTGATACCAAGCGGCTGCTTTATTATCTTCAGACCTGTCAGATGGAAAGTCCCTTTGTTTTGCCGACCTTATCCAAAGAATCGCTGGAACAGCCTTTGAAGAAAAAACTGAAAATAGCCGTATTGTTTGATTCACCTATTGCTAGTCGCGTTTCTCGCTCAGCTATTTCTGCCGTTCAGCAAACGGTTAAATTTCTGGAAGCAGCGGGTCATAGGGTAGAAGAAGTGTCACAACCTTTAAATGGTATAGAGGCCATGAAGTCCTACTATATTATGAATAGTGTCGAAACGGCTGCCATGTTTGACGGGCTTGCCGCTTCCTTGGGACGCCCTTTGACACTGGATGATATGGAGGTCATGTCTTGGGCACTCTATCAATCCGGTCAAAAGATTCCTGCCAAATCTTATTCTAAGATACTCAATCAATGGGATCAATACAGTCATCGCATGGCTGTCTTTCATGAAAAGTATGATCTTATTCTAACACCGACAACAGCTGAAGTTGCACCTAAACACGATCAATTTCAATTGTCAAGTACTTTAGAAAATAAATTAAAGCATATAACTGATTTTGATAGGAATTGCCAGCAAGAGCTCATTTGGGAGATGTTTGCTGACAGTTTAGCTTGGACGCCCTTTACACAGCAGGCCAATCTAACAGGACAGCCCGCCATCTCTCTACCGCTTTATCGAGATAAGCAGGGTCTGTCACTTGGTGTTCAATTGACAGCTGCTAAAGGCAGAGAAGATTTGCTTTTAGCTCTTGCACAGTCATTTGAGGAGCAGTCACTTTTTGTCTAA","8.20","3.10","52749","MQFPDATAMANAVKQKDVSPRELVKWTIEKAEKHNPSLNAIVSQRYERALQEARERDFTGKPFAGVPLFLKDLGQEQAGELSTSGSRLLANYHASHSDNYVKSLEALGFIILGRTNTPEFGFKNISDSSLHGQVNLPDDVSRNAGGSSGGAAALVSSGVVPLAAASDGGGSIRIPTSFNGLIGLKPTRGRIPVGPTSFRGWQGASVQFALTKTVRDTKRLLYYLQTCQMESPFVLPTLSKESLEQPLKKKLKIAVLFDSPIASRVSRSAISAVQQTVKFLEAAGHRVEEVSQPLNGIEAMKSYYIMNSVETAAMFDGLAASLGRPLTLDDMEVMSWALYQSGQKIPAKSYSKILNQWDQYSHRMAVFHEKYDLILTPTTAEVAPKHDQFQLSSTLENKLKHITDFDRNCQQELIWEMFADSLAWTPFTQQANLTGQPAISLPLYRDKQGLSLGVQLTAAKGREDLLLALAQSFEEQSLFV","1160024","","Gln-dependent amidotransferase, subunit A","Periplasm, Cytoplasm","Several matches in gapped BLAST to amidase: residues 1-478 are 56% similar to the enzyme in S.pyogenes (gi15674924). Residues 1-479 are 38% similar to the protein from Lactococcus lactis (gi15672148).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1611 (1e-158).","

InterPro
IPR000120
Family

Amidase
PTHR11895	$\"[14-389]T$ $\"[418-479]T$	Amidase
PF01425	$\"[22-467]T$	Amidase
PS00571	$\"[145-176]T$	AMIDASES

noIPR
unintegrated

unintegrated
G3DSA:3.90.1300.10	$\"[5-475]T$	G3DSA:3.90.1300.10
PTHR11895:SF7	$\"[14-389]T$ $\"[418-479]T$	PTHR11895:SF7
SSF75304	$\"[5-475]T$	SSF75304

","BeTs to 15 clades of COG0154COG name: Glu-tRNAGln amidotransferase A subunit (amidase)Functional Class: JThe phylogenetic pattern of COG0154 is Amt-YqvC-bR-ujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000120 (Amidase) with a combined E-value of 2.5e-26. IPB000120 136-189","Residues 363-470 are 34% similar to a (SUBUNIT AMIDOTRANSFERASE GLUTAMYL-TRNAGLN 6.3.5.-) protein domain (PD002554) which is seen in AMI3_MYCLE.Residues 275-388 are 40% similar to a (HYDROLASE PROTEOME AMIDASE COMPLETE) protein domain (PD282434) which is seen in Q9CJ40_LACLA.Residues 1-104 are 38% similar to a (PROTEOME COMPLETE AMIDASE) protein domain (PD394313) which is seen in Q9CJ40_LACLA.Residues 427-475 are 55% similar to a (HYDROLASE PROTEOME AMIB2) protein domain (PD119745) which is seen in Q9RXS1_DEIRA.Residues 104-219 are 52% similar to a (HYDROLASE SUBUNIT AMIDOTRANSFERASE BIOSYNTHESIS AMIDASE) protein domain (PD038838) which is seen in Q9CJ40_LACLA.Residues 363-462 are 32% similar to a (AMIC AMIDASE HYDROLASE) protein domain (PD309496) which is seen in AMI3_MYCTU.Residues 391-479 are 38% similar to a (PROTEOME COMPLETE AMIDASE) protein domain (PD393767) which is seen in Q9CJ40_LACLA.Residues 10-116 are 35% similar to a (HYDROLASE SUBUNIT AMIDOTRANSFERASE BIOSYNTHESIS) protein domain (PD001110) which is seen in NYLA_PSES8.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 09:20:11 2002","Thu Sep 28 14:47:11 2006","Thu Sep 28 14:47:11 2006","Tue Feb 26 09:17:38 2002","Tue Feb 26 09:17:38 2002","Tue Feb 26 09:17:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1113 is paralogously related (blast p-value < 1e-3) to SMu1658 ,a predicted glutamyl-tRNA(Gln) amidotransferase, A subunit .","Tue Feb 26 09:33:42 2002","","No significant hits to the NCBI PDB database.","SMU.1218c","","Residues 22 to 467 (E-value = 1.8e-56) place SMu1113 in the Amidase family which is described as Amidase (PF01425)","Tue Feb 26 09:17:38 2002","","","","Harpel MR, Horiuchi KY, Luo Y, Shen L, Jiang W, Nelson DJ, Rogers KC, Decicco CP, Copeland RA.Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate aserine-based glutaminase site.Biochemistry. 2002 May 21;41(20):6398-407.PMID: 12009902 Horiuchi KY, Harpel MR, Shen L, Luo Y, Rogers KC, Copeland RA.Mechanistic studies of reaction coupling in Glu-tRNAGln amidotransferase.Biochemistry. 2001 May 29;40(21):6450-7.PMID: 11371208","","Thu Oct 17 14:06:29 2002","1","","","SMU.1218c","843" "SMu1114","1161852","1161511","342","ATGAAATTCACAAAACGTCAGCTTTTAGATTGGCTGTTGGATGTAACGGGAGCTGAGGAAGTCTATCCTTTTACCCGAGAAAAAAGCAAGTACACGCCCGTCATTCGACATAGGCGTAATCAAAAGATGCTGGCTTTAGTAACAGAAAAAGATGGTAATCTCCTTCTAAATCTTAAGCTCAAACCAGAACAGGTAGAAAATATGCTGGAAACTAAAGGTGTGATTCCAGCCTATCATATGAATAAGAAACACTGGCTTACAGTTTTGGTTAACGAAACAGAATTAACGGAGAATGAATTGAAAAATATGGTATTGGAAAGCAGTCAATTGACGCAGGGCTAA","9.70","2.72","13250","MKFTKRQLLDWLLDVTGAEEVYPFTREKSKYTPVIRHRRNQKMLALVTEKDGNLLLNLKLKPEQVENMLETKGVIPAYHMNKKHWLTVLVNETELTENELKNMVLESSQLTQG","1161526","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypotheticals:residues 5-85 are 33% similar to hypothetical protein from Lactococcus lactis (gi|15674158|) and residues 27-85 are 35% similar to the protein from S.pneumoniae (gi|15903181|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0449 (0.001).","

InterPro
IPR007351
Family

Protein of unknown function DUF419
PF04237	$\"[12-112]T$	DUF419

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-85 are 33% similar to a (PROTEOME APHA-UVRA COMPLETE Y) protein domain (PD076121) which is seen in Q9CDP3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 09:40:52 2002","Tue Feb 26 09:37:30 2002","Tue Feb 26 09:37:30 2002","Tue Feb 26 09:37:30 2002","","Tue Feb 26 09:37:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1114 is paralogously related (blast p-value < 1e-3) to SMu0462, a predicted conserved hypothetical protein.","Tue Feb 26 09:40:52 2002","","No significant hits to the NCBI PDB database.","SMU.1219c","","Residues 12 to 112 (E-value = 1.2e-18) place SMu1114 in the DUF419 family which is described as Protein of unknown function (DUF419) (PF04237)","Tue Feb 26 09:37:30 2002","24379643","","","","","","1","","","SMU.1219c","" "SMu1115","1162526","1162026","501","ATGAAAATTCATGTGCCATTTAAAAATCATATTATCCCTGATGCTTATGCTAAAAAAGCAAGTGAAACTAATAAAGGTTATGCTGTTAAATCTTTTCCTTTTGAAATTGTAGACATTCCAGAGAATGCTAAAACCTTAGCTTGGACTTTGGTAGATTATGATTCTATTCCTGTTTGCGGTTTTGCCTATATTCATTGGACTGTTGCTAATGTACCAACAGATGTCACTGTTATTTCAGAGGATTTTGCAAGACAAGATCAAAAGCATTTAAAGGGGAAAAACAGTCTGGTCAGCAAGTTCCTAACAACTGATTATTCTGATATGTACGATGGTTACCTTGGCCCTTATCCGCCAGACAAAGATCATCACTACACCCTTACTGTCTATGCGCTTGATGATGACTTATCTCTTGATGCGGGTTTCTATCTTAATGAACTCTTACATGCAATTGAAGGTCATGTAATTGCCCAAGCTCAAATGGATTTGGTGGGCAGAGCATAA","5.20","-7.13","18681","MKIHVPFKNHIIPDAYAKKASETNKGYAVKSFPFEIVDIPENAKTLAWTLVDYDSIPVCGFAYIHWTVANVPTDVTVISEDFARQDQKHLKGKNSLVSKFLTTDYSDMYDGYLGPYPPDKDHHYTLTVYALDDDLSLDAGFYLNELLHAIEGHVIAQAQMDLVGRA","1162041","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-165 are 50% similar to gi|15923970| from S.aureus and are 44% similar to gi|16080938 from B.subtilis SMu1115 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005247
Family

YbhB and YbcL
TIGR00481	$\"[16-164]T$	YbhB_YbcL

InterPro
IPR008914
Family

PEBP
PF01161	$\"[4-166]T$	PBP

noIPR
unintegrated

unintegrated
G3DSA:3.90.280.10	$\"[1-160]T$	G3DSA:3.90.280.10
SSF49777	$\"[1-160]T$	SSF49777

","BeTs to 9 clades of COG1881COG name: Uncharacterized ACR, YbhB familyFunctional Class: SThe phylogenetic pattern of COG1881 is a-tkYq--EbR-uj----in-Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 33-155 are 47% similar to a (COMPLETE PROTEOME YBHB PH1269) protein domain (PD006154) which is seen in P94355_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 09:44:29 2002","Tue Feb 26 09:44:29 2002","Tue Feb 26 09:44:29 2002","Tue Feb 26 09:44:29 2002","","Tue Feb 26 09:44:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1115 is paralogously related (blast p-value < 1e-3) to SMu1531, a predicted conserved hypothetical protein.","Tue Feb 26 09:44:29 2002","","No significant hits to the NCBI PDB database.","SMU.1220c","","Residues 4 to 166 (E-value = 6.6e-06) place SMu1115 in the PBP family which is described as Phosphatidylethanolamine-binding protein (PF01161)","Tue Feb 26 09:44:29 2002","24379644","","","","","","1","","","SMU.1220c","" "SMu1116","1163487","1162858","630","ATGACATTAGCAAAAGACATCGCTCGTGATTTACTAGATATCAAGGCCGTATATCTTAAGCCAGAAGAACCTTTTACTTGGGCATCTGGCATTAAATCACCCATTTACACAGACAATCGCATCACGCTTTCCTATCCTGAAACACGTACTTTGATTGAAAATGGTTTTGTGGAAACCATCAAGGAAGCATTTCCTGAGGTAGAAGTTATTGCAGGAACAGCAACAGCAGGGATTCCTCATGGTGCTATTATTGCAGATAAGATGAATTTGCCCTTTGCTTATATTCGCAGCAAACCAAAAGATCATGGTGCAGGTAATCAAATTGAAGGTCGTGTGACTAAGGGACAAAAAATGGTCATCATTGAAGATTTGATTTCAACAGGTGGCTCTGTACTGGATGCCGTGGCAGCTGCGCAACGTGAAGGTGCTGACGTGCTTGGTGTGGTTGCCATTTTTACCTACGAATTACCAAAAGCAACAGCCAATTTTGAAAAGGCTAGTGTGAAATTGGTGACTTTGTCAAACTACAGCGAACTGATTAAAGTTGCTAAGGTACAAGGCTATATTGATGCAGACGGTTTAACCCTGCTCAAGAAATTTAAAGAAAACCAAGAGACTTGGCAAGACTAA","5.20","-3.51","22801","MTLAKDIARDLLDIKAVYLKPEEPFTWASGIKSPIYTDNRITLSYPETRTLIENGFVETIKEAFPEVEVIAGTATAGIPHGAIIADKMNLPFAYIRSKPKDHGAGNQIEGRVTKGQKMVIIEDLISTGGSVLDAVAAAQREGADVLGVVAIFTYELPKATANFEKASVKLVTLSNYSELIKVAKVQGYIDADGLTLLKKFKENQETWQD","1162873","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1117 (pyrF); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH).","orotate phosphoribosyltransferase","Cytoplasm","Several matches in gapped BLAST to orotate phosphoribosyltransferase: residues 1-208 are 85% similar to the enzyme in S.pyogenes (gi|15674923|). Residues 1-209 are 83% similar to the protein from S.pneumoniae (gi|400948|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1046 (4e-89).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[38-166]T$	Pribosyltran

InterPro
IPR002375
Family

Purine/pyrimidine phosphoribosyl transferase
PS00103	$\"[118-130]T$	PUR_PYR_PR_TRANSFER

InterPro
IPR004467
Domain

Orotate phosphoribosyl transferase
TIGR00336	$\"[9-179]T$	pyrE

noIPR
unintegrated

unintegrated
SSF53271	$\"[5-207]T$	SSF53271

","BeTs to 13 clades of COG0461COG name: Orotate phosphoribosyltransferaseFunctional Class: FThe phylogenetic pattern of COG0461 is amtkYqvcebrhuj-----n-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 118-208 are 74% similar to a (TRANSFERASE OROTATE GLYCOSYLTRANSFERASE) protein domain (PD061282) which is seen in Q9ZHA6_STRPN.Residues 11-117 are 92% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE OROTATE) protein domain (PD001420) which is seen in Q9ZHA6_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:12:33 2002","Tue Feb 26 09:55:55 2002","Thu Oct 17 14:12:33 2002","Tue Feb 26 09:55:55 2002","","Tue Feb 26 09:55:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1116 is paralogously related (blast p-value < 1e-3) to SMu0958, a predicted phosphoribosyl pyrophosphate.","Tue Feb 26 09:59:04 2002","","No significant hits to the NCBI PDB database.","SMU.1221c","","Residues 38 to 166 (E-value = 2.7e-31) place SMu1116 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Tue Feb 26 09:55:55 2002","","","","Quinn,C.L., Stephenson,B.T. and Switzer,R.L.Functional organization and nucleotide sequence of the Bacillussubtilis pyrimidine biosynthetic operonJ. Biol. Chem. 266 (14), 9113-9127 (1991)PubMed: 1709162","","Tue Feb 26 09:58:06 2002","1","","","SMU.1221c","560" "SMu1117","1164280","1163588","693","ATGCGTGAACCCCGTCCCTTAATTGCTCTTGATTTTCCTTCTTTTGATGATGTGAAATCCTTCTTAGCACAATTCCCACCAGAAGAGAAACTTTATGTTAAAATTGGTATGGAACTCTATTATGCTGTCGGTCCAGAGATTGTGCGCTATGTGAAAGGTCTTGGCCATTCGGTCTTTCTTGATTTAAAATTGCATGATATTCCCAATACGGTCAAATCAGCTATGAAGGTGCTATCTGATCTTGGTGTAGATATGACTAATGTTCATGCGGCTGGCGGTGTTGAAATGATGAAGGCAGCGCGTGAAGGTTTGGGAAAAGGTCCAAAACTGATCGCGGTGACCCAATTAACTTCAACGTCTGAAGAACAGATGCATGATTTCCAAAACATTCAAACCAGCTTAGCGGAGTCAGTTGTTCATTATGCCAAGAAGACTGCGGAAGCTGGTCTTGATGGAGTTGTCTGCTCTGCTCATGAAGTGGAAGCCATCAAATCAGCCACGTCGAATGATTTTGTCTGTCTAACACCGGGTATTCGTCCAGCGGGCTCTGCCATTGGTGACCAAAAACGCATCATGACACCAGCAGACGCACGTACCATTGGTTCAGACTATATCGTGCTAGGACGCCCTATCACGCGAGCAGAGGATCCAATAGCCGCCTATCAAGCGATTAAAGCTGAATGGAATGGCTAG","6.00","-3.65","24901","MREPRPLIALDFPSFDDVKSFLAQFPPEEKLYVKIGMELYYAVGPEIVRYVKGLGHSVFLDLKLHDIPNTVKSAMKVLSDLGVDMTNVHAAGGVEMMKAAREGLGKGPKLIAVTQLTSTSEEQMHDFQNIQTSLAESVVHYAKKTAEAGLDGVVCSAHEVEAIKSATSNDFVCLTPGIRPAGSAIGDQKRIMTPADARTIGSDYIVLGRPITRAEDPIAAYQAIKAEWNG","1163603","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1118 (pyrD); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH). ","orotidine 5'-phosphate decarboxylase","Cytoplasm","Several matches in gapped BLAST to orotidine-5'-decarboxylase: residues 1-228 are 82% similar to the enzyme in S.pneumoniae (gi7387625).Residues 1-230 are 74% similar to the protein from S.pyogenes (gi15674922).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1047 (9e-84).","

InterPro
IPR001754
Domain

Orotidine 5'-phosphate decarboxylase, core
PF00215	$\"[4-224]T$	OMPdecase
PS00156	$\"[58-71]T$	OMPDECASE

InterPro
IPR011060
Domain

Ribulose-phosphate binding barrel
SSF51366	$\"[1-229]T$	RibP_bind_barrel

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-228]T$	Aldolase_TIM

InterPro
IPR014732
Domain

Orotidine 5'-phosphate decarboxylase, subfamily 1, core
TIGR01740	$\"[6-225]T$	pyrF

","BeTs to 10 clades of COG0284COG name: Orotidine-5'-phosphate decarboxylaseFunctional Class: FThe phylogenetic pattern of COG0284 is amtkyqvceb-huj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 108-230 are 54% similar to a (DECARBOXYLASE BIOSYNTHESIS 5'-PHOSPHATE) protein domain (PD004586) which is seen in DCOP_BACCL.Residues 16-224 are 46% similar to a (DECARBOXYLASE OROTIDINE OMP 5'-PHOSPHATE) protein domain (PD277339) which is seen in DCOP_ECOLI.Residues 7-220 are 83% similar to a (DECARBOXYLASE LYASE SYNTHASE PYRIMIDINE BIOSYNTHESIS) protein domain (PD001042) which is seen in DCOP_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 11:29:35 2006","Wed Aug 30 11:29:35 2006","Wed Aug 30 11:29:35 2006","Wed Aug 30 11:29:35 2006","","Wed Aug 30 11:29:35 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1117 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 10:04:20 2002","Wed Aug 30 11:29:35 2006","pdb1DBTA Chain A, Crystal Structure Of Orotidine 5'-Monophosp... 249 2e-067pdb1EIXC Chain C, Structure Of Orotidine 5'-Monophosphate Dec... 184 7e-048","SMU.1222c","","Residues 4 to 224 (E-value = 6.9e-89) place SMu1117 in the OMPdecase family which is described as Orotidine 5'-phosphate decarboxylase / HUMPS family (PF00215)","Wed Aug 30 11:29:35 2006","","","","Andersen,P.S., Martinussen,J. and Hammer,K.Sequence analysis and identification of the pyrKDbF operon fromLactococcus lactis including a novel gene, pyrK, involved inpyrimidine biosynthesisJ. Bacteriol. 178 (16), 5005-5012 (1996)PubMed: 8759867","","Tue Feb 26 10:07:27 2002","1","","","SMU.1222c","561" "SMu1118","1165202","1164273","930","ATGACAAATAGACTTGCTCTTAAATTGCCGGGCTTGGATTTGAAAAATCCTATCATTCCAGCCTCAGGCTGTTTTGGCTTTGGTCAAGAATATGCTAAATATTATGACTTAAATAAATTGGGTTCTATCATGATTAAGGCAACGACCCAGCAGCCGCGCTTTGGAAATCCCACAGCACGTGTTGCAGAAACCCCTTCAGGAATGCTCAATGCCATTGGTCTGCAAAATCCGGGTGTTGATGCTGTCATTGCTCAAAAATTGCCTTGGCTGGCAGAGCATTACCCAGATTTACCAATTATTGCCAATGTTGCTGGTTTTTCCAATGAAGAATATGCTTATGTGTCTGAAAAAATCTCACAGGCACCAAATGTCAAGGCTATTGAGCTTAATATTTCCTGTCCTAACGTTGACCACGGGAATCATGGCCTGCTTATTGGACAGGTGCCAGAACTAACTTATGCTGCAGTTAAAGCTGCTGTTGAGGCTTCTCAGGTACCCGTTTATGTTAAGCTGACACCTAGTGTTGCCGATATTACAACTGTTGCTAAGGCAGTTGAAGCTGCTGGAGCGACTGGCTTTACCATGATCAACACTTTGGTTGGTATGCGTTTTGATTTAAAGACTAAAAAACCTATCATTGCCAATGGTACAGGTGGTATGAGTGGTCCAGCAGTCTTTCCAGTAGCTCTCAAATTAATTCATCAAGTGGCTCAGTCGTCTCAGTTGCCAATCATTGGTATGGGTGGTGTTGATTCAGCTGAAGCCGCCTTAGAAATGATGATAGCTGGTGCCTCGGCGATTGCTGTTGGGACAGCTAATTTTACAGACCCCTTTGCCTGTCCTAATATCATTGAAGACTTACCTAAGGTTATGGATAAATATGGTATTGAAACGCTTGAACAATTCAGAAAGGATGTTAGAAATGCGTGA","6.10","-2.18","32666","MTNRLALKLPGLDLKNPIIPASGCFGFGQEYAKYYDLNKLGSIMIKATTQQPRFGNPTARVAETPSGMLNAIGLQNPGVDAVIAQKLPWLAEHYPDLPIIANVAGFSNEEYAYVSEKISQAPNVKAIELNISCPNVDHGNHGLLIGQVPELTYAAVKAAVEASQVPVYVKLTPSVADITTVAKAVEAAGATGFTMINTLVGMRFDLKTKKPIIANGTGGMSGPAVFPVALKLIHQVAQSSQLPIIGMGGVDSAEAALEMMIAGASAIAVGTANFTDPFACPNIIEDLPKVMDKYGIETLEQFRKDVRNA","1164288","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1119 (pyrDII),(pyrZ) and SMu1479 (pyrH).For dihydroorotate dehydrogenase electron transfer subunit see SMu1119.","dihydroorotate dehydrogenase","Cytoplasm, Periplasm","Several matches in gapped BLAST to dihydroorotate dehydrogenase:residues 2-309 are 80% similar to the enzyme in S.pneumoniae (gi|15902910|).Residues 3-309 are 70% similar to the protein from Lactococcus lactis (gi|15673328|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0507 (7e-24).","

InterPro
IPR001295
Domain

Dihydroorotate dehydrogenase, core
PF01180	$\"[4-291]T$	DHO_dh
PS00912	$\"[244-264]T$	DHODEHASE_2

InterPro
IPR005720
Domain

Dihydroorotate dehydrogenase, class 1, core
TIGR01037	$\"[5-299]T$	pyrD_sub1_fam

InterPro
IPR012135
Family

Dihydroorotate dehydrogenase, classes 1 and 2
PIRSF000164	$\"[5-307]T$	DHO_oxidase

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[4-304]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR11938	$\"[15-303]T$	PTHR11938
PTHR11938:SF5	$\"[15-303]T$	PTHR11938:SF5
SSF51395	$\"[4-304]T$	SSF51395

","BeTs to 12 clades of COG0167COG name: Dihydroorotate dehydrogenaseFunctional Class: FThe phylogenetic pattern of COG0167 is amtkyqvCEbrhuj-------Number of proteins in this genome belonging to this COG is 2","***** IPB001295 (Dihydroorotate dehydrogenase) with a combined E-value of 1.4e-56. IPB001295A 11-22 IPB001295B 39-62 IPB001295C 69-78 IPB001295D 124-138 IPB001295E 166-176 IPB001295F 181-199 IPB001295G 218-231 IPB001295H 242-272","Residues 129-264 are 34% similar to a (DIHYDROOROTATE DEHYDROGENASE) protein domain (PD123513) which is seen in PYRD_DEIRA.Residues 12-290 are 71% similar to a (DIHYDROOROTATE DEHYDROGENASE OXIDOREDUCTASE FLAVOPROTEIN) protein domain (PD001761) which is seen in Q9CFW8_LACLA.Residues 15-110 are 34% similar to a (A DIHYDROOROTATE DEHYDROGENASE DHODEHASE) protein domain (PD407423) which is seen in PYRD_YEAST.Residues 119-272 are 38% similar to a (DIHYDROOROTATE DEHYDROGENASE) protein domain (PD415821) which is seen in DPYD_PIG.Residues 25-278 are 21% similar to a (PYRIMIDINE DEHYDROGENASE OXIDOREDUCTASE) protein domain (PD123494) which is seen in DHDO_DICDI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:14:01 2002","Tue Feb 26 10:39:27 2002","Thu Oct 17 14:14:01 2002","Tue Feb 26 10:38:08 2002","Tue Feb 26 10:38:08 2002","Tue Feb 26 10:38:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1118 is paralogously related (blast p-value < 1e-3) to SMu0542,a predicted dihydroorotate dehydrogenase;dihydroorotate oxidase; SMu1588,a predicted trans-2-enoyl-ACP reductase II; and SMu0169, a predicted conserved hypothetical protein, possible dehydrogenase.","Tue Feb 26 10:44:43 2002","Tue Feb 26 10:38:08 2002","pdb|1EP1|A Chain A, Crystal Structure Of Lactococcus Lactis Dih... 430 8e-122pdb|2DOR|A Chain A, Dihydroorotate Dehydrogenase A From Lactoco... 102 6e-023pdb|1D3G|A Chain A, Human Dihydroorotate Dehydrogenase Complexe... 70 3e-013","SMU.1223c","","Residues 4 to 291 (E-value = 1.4e-129) place SMu1118 in the DHO_dh family which is described as Dihydroorotate dehydrogenase (PF01180)","Tue Feb 26 10:38:08 2002","","","","Andersen,P.S., Jansen,P.J. and Hammer,K.Two different dihydroorotate dehydrogenases in Lactococcus lactisJ. Bacteriol. 176 (13), 3975-3982 (1994)PubMed: 8021180Marcinkeviciene,J., Tinney,L.M., Wang,K.H., Rogers,M.J. andCopeland,R.A.Dihydroorotate dehydrogenase B of Enterococcus faecalis.Characterization and insights into chemical mechanismBiochemistry 38 (40), 13129-13137 (1999)PubMed: 10529184","","Tue Feb 26 10:41:40 2002","1","","","SMU.1223c","" "SMu1119","1165988","1165212","777","ATGATTTTAAAAGAAAATCTAACGGTAGTTAGTCAACGTGAAATTGCTCCTCGTATTTTTGAAATGGTTTTAAAGGGTGATATGGTTGCGCAAATGCAGGCCGGTCAGTTCTTGCATATTCGTGTTCCTGATGCTAGTAAACTCTTGCGCCGACCAATTTCCATAGCTGACATTAACAAAGAAGCTCAAGAAGCTACCATTATTTACCGTATTGAAGGTCGGGGAACGGCTATCTTTTCTCAACTTAAAGCAGGAGATAAGCTTGATTGTTTAGGTCCTCAAGGCAATGGCTTTGACCTTTCTGTCATTGATAAAGGTCAAAAGGCTTTGATTATTGGCGGTGGTATTGGTGTTCCGCCTTTATTGGAAGTGGCTAAGCAACTTTGCAAAAAAGGCGTGGAAGCCTATGCTGTTTTGGGCTTTGCCAACAAAGATGCGGTGATTTTGGAAGAAAAGATGTCTCAATATGCAACTGTTGTGGTAACAACAGATGATGGTTCTTACGGTCAAAAGGGTTATGTATCAACGGTCGTTGATAATTTGGATTTTCTTGCTGACGCCATCTATGCTTGCGGCGCACCTGGAATGCTTAAATATGTTGATAAGAAATTTGAAAAGCACCCGCATGCTTATTTATCAACAGAGGAACGGATGGCTTGCGGTATGGGAGCATGTTATGCCTGCGTCGTTCATGTCAAAGGTCAAGAAGATGCTCAAAACCTGCGTGTTTGTGAAGATGGGCCTATATTTGAAACTGGTCAGATTATTCTAGATTAG","5.50","-4.36","28016","MILKENLTVVSQREIAPRIFEMVLKGDMVAQMQAGQFLHIRVPDASKLLRRPISIADINKEAQEATIIYRIEGRGTAIFSQLKAGDKLDCLGPQGNGFDLSVIDKGQKALIIGGGIGVPPLLEVAKQLCKKGVEAYAVLGFANKDAVILEEKMSQYATVVVTTDDGSYGQKGYVSTVVDNLDFLADAIYACGAPGMLKYVDKKFEKHPHAYLSTEERMACGMGACYACVVHVKGQEDAQNLRVCEDGPIFETGQIILD","1165227","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD) and SMu1479 (pyrH).From Genbank:[gi:141329]This enzyme is probably an electron carrier protein involved in the transfer of reducing equivalents from the flavoprotein subunit (PYRD) to the electron transport system in the cell membrane.","dihydroorotate dehydrogenase electron transfer subunit","Cytoplasm","Several matches in gapped BLAST to dihydroorotate dehydrogenase, electron transfer subunit: residues 1-257 are 60% similar to the enzyme in S.pneumoniae (gi|15902909|). Residues 3-257 are 50% similar to the protein from Lactococcus lactis (gi|15673329|).SMu1119 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000951
Domain

Phthalate dioxygenase reductase, FPNCR module
PR00409	$\"[26-36]T$ $\"[110-129]T$ $\"[187-195]T$	PHDIOXRDTASE

InterPro
IPR001433
Domain

Oxidoreductase FAD/NAD(P)-binding
PF00175	$\"[110-202]T$	NAD_binding_1

InterPro
IPR008333
Domain

Oxidoreductase FAD-binding region
PF00970	$\"[6-100]T$	FAD_binding_6

InterPro
IPR012165
Family

Cytochrome-c3 hydrogenase, gamma subunit
PIRSF006816	$\"[2-258]T$	Cyc3_hyd_g

noIPR
unintegrated

unintegrated
G3DSA:2.10.240.10	$\"[215-257]T$	G3DSA:2.10.240.10
G3DSA:2.40.30.10	$\"[4-96]T$	G3DSA:2.40.30.10
G3DSA:3.40.50.80	$\"[100-214]T$	G3DSA:3.40.50.80
PTHR11938	$\"[1-170]T$	PTHR11938
PTHR11938:SF7	$\"[1-170]T$	PTHR11938:SF7
SSF52343	$\"[99-257]T$	SSF52343
SSF63380	$\"[1-98]T$	SSF63380

","BeTs to 8 clades of COG0543COG name: 2-Octaprenylphenol hydroxylase and related flavodoxin oxidoreductasesFunctional Class: H,CThe phylogenetic pattern of COG0543 is amtKYQV-EbRh-----lin-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-132 are 49% similar to a (ELECTRON TRANSFER DEHYDROGENASE) protein domain (PD155021) which is seen in PYRK_BACCL.Residues 9-132 are 42% similar to a (PROTEOME COMPLETE GAMMA HYDROGENASE) protein domain (PD186942) which is seen in Q9K9W0_BACHD.Residues 211-250 are 62% similar to a (ELECTRON SUBUNIT DIHYDROOROTATE TRANSFER) protein domain (PD187885) which is seen in PYRK_LACLC.Residues 138-200 are 49% similar to a (ELECTRON SUBUNIT TRANSFER DEHYDROGENASE) protein domain (PD149798) which is seen in PYRK_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:15:07 2002","Tue Feb 26 10:50:29 2002","Thu Oct 17 14:15:07 2002","Tue Feb 26 10:50:29 2002","","Tue Feb 26 10:50:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1119 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 10:52:00 2002","Tue Feb 26 10:50:29 2002","pdb|1EP3|B Chain B, Crystal Structure Of Lactococcus Lactis Dih... 245 4e-066pdb|1EP1|B Chain B, Crystal Structure Of Lactococcus Lactis Dih... 245 4e-066","SMU.1224c","","Residues 6 to 100 (E-value = 6.1e-07) place SMu1119 in the FAD_binding_6 family which is described as Oxidoreductase FAD-binding domain (PF00970)","Tue Feb 26 10:50:29 2002","","","","Andersen,P.S., Martinussen,J. and Hammer,K.Sequence analysis and identification of the pyrKDbF operon fromLactococcus lactis including a novel gene, pyrK, involved inpyrimidine biosynthesisJ. Bacteriol. 178 (16), 5005-5012 (1996)PubMed: 8759867Ghim,S.Y., Nielsen,P. and Neuhard,J.Molecular characterization of pyrimidine biosynthesis genes fromthe thermophile Bacillus caldolyticusMicrobiology 140 (Pt 3), 479-491 (1994)PubMed: 7516791Quinn,C.L., Stephenson,B.T. and Switzer,R.L.Functional organization and nucleotide sequence of the Bacillussubtilis pyrimidine biosynthetic operonJ. Biol. Chem. 266 (14), 9113-9127 (1991)PubMed: 1709162Kahler,A.E. and Switzer,R.L.Identification of a novel gene of pyrimidine nucleotidebiosynthesis, pyrDII, that is required for dihydroorotatedehydrogenase activity in Bacillus subtilisJ. Bacteriol. 178 (16), 5013-5016 (1996)PubMed: 8759868Kahler,A.E., Nielsen,F.S. and Switzer,R.L.Biochemical characterization of the heteromeric Bacillus subtilisdihydroorotate dehydrogenase and its isolated subunitsArch. Biochem. Biophys. 371 (2), 191-201 (1999)PubMed: 10545205","","Tue Feb 26 10:55:25 2002","1","","","SMU.1224c","" "SMu1120","1166241","1167149","909","ATGCGTATTCAACAGTTACATTATATTATCAAAATTGTCGAAACTGGCAGCATGAATGAGGCTGCCAAACAACTATTTATTACTCAGCCTTCACTTTCAAACGCGGTTCGTGATTTGGAACGCGAAATGGGTATTGAAATCTTTATCCGCAACCCTAAAGGGATCACCCTGACTAAGGATGGTGTTGAATTCCTATCCTATGCCCGCCAAGTTGTTGAGCAGACAGCTCTTTTAGAGGAACGCTATAAAAGCCAAGGTCATACGCGTGAACTTTTTAGTGTTTCAGCTCAGCACTACGCCTTTGTGGTTAATGCCTTTGTCAGTCTGCTTAAGGAAACTGATATGACGCGTTATGAGCTTTTTTTACGTGAAACCAGAACCTACGAAATTATTGATGACGTGAAAAATTTCCGCTCTGAAATTGGGGTGCTTTTCCTAAATAGTTACAATCATGATGTTCTCACCAAAATGTTTGATGACAATCATTTGACTTATACCAGCCTTTTCAAAGCACATCCCCATATTTTTGTCAGTAAGGATAATCCTTTAGCTAAACATCAGTCCGTATCTCTCAGCGATTTAGAAGACTTTCCCTACCTCAGTTATGACCAGGGTATCCATAACTCCTTCTACTTTTCAGAGGAAATTATGTCACAGATTTCTCATAAAAAATCTATTGTTGTTTCCGACCGAGCGACTCTCTTCAATCTGATGATTGGTCTTGACGGCTATACCATTGCAACTGGGATTTTAAATAGTAACCTTAACGGCGACAATATCGTTTCGATTCCGCTTGAAGTAGACGATGAAATTGACATCATTTACCTTAAGCATGAAAAAGCTAATCTTTCCAAAATGGGGGAAAAATTTATCGACTATCTTCTTGAAGAAGTTAAATTTGATAAATAG","5.30","-10.33","34874","MRIQQLHYIIKIVETGSMNEAAKQLFITQPSLSNAVRDLEREMGIEIFIRNPKGITLTKDGVEFLSYARQVVEQTALLEERYKSQGHTRELFSVSAQHYAFVVNAFVSLLKETDMTRYELFLRETRTYEIIDDVKNFRSEIGVLFLNSYNHDVLTKMFDDNHLTYTSLFKAHPHIFVSKDNPLAKHQSVSLSDLEDFPYLSYDQGIHNSFYFSEEIMSQISHKKSIVVSDRATLFNLMIGLDGYTIATGILNSNLNGDNIVSIPLEVDDEIDIIYLKHEKANLSKMGEKFIDYLLEEVKFDK","1167158","","transcriptional regulator, LysR family; probable metCcysK operon transcriptional activator","Cytoplasm","Several matches in gapped BLAST to transcriptional regulator: residues 1-301 are 84% similar to the protein in S.pneumoniae (gi15900577) and are 83% similar to the protein from S.pyogenes (gi15674920).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1176 (1e-133).","

InterPro
IPR000847
Domain

Bacterial regulatory protein, LysR
PR00039	$\"[18-29]T$ $\"[29-39]T$ $\"[39-50]T$	HTHLYSR
PF00126	$\"[3-62]T$	HTH_1
PS50931	$\"[1-58]T$	HTH_LYSR

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-87]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-104]T$	SSF46785
SSF53850	$\"[119-299]T$	SSF53850

","BeTs to 7 clades of COG0583COG name: Transcriptional regulators, LysR familyFunctional Class: KThe phylogenetic pattern of COG0583 is aMt--Q-CEBRH---------Number of proteins in this genome belonging to this COG is 5","***** IPB000847 (Bacterial regulatory protein, LysR family) with a combined E-value of 2.7e-10. IPB000847 17-50","Residues 6-73 are 36% similar to a (DNA-BINDING REGULATION TRANSCRIPTION TRANSCRIPTIONAL) protein domain (PD254092) which is seen in Q9RHQ5_BBBBB.Residues 79-278 are 78% similar to a (REGULATION TRANSCRIPTION DNA-BINDING CPSY) protein domain (PD407814) which is seen in Q9R3E1_STRAG.Residues 1-71 are 88% similar to a (TRANSCRIPTIONAL DNA-BINDING REGULATION REGULATOR) protein domain (PD000161) which is seen in Q9R3E1_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 11:04:41 2002","Wed Sep 13 11:21:31 2006","Wed Sep 13 11:21:31 2006","Tue Feb 26 11:02:57 2002","Tue Feb 26 11:02:57 2002","Tue Feb 26 11:02:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1120 is paralogously related (blast p-value < 1e-3) to SMu0844, SMu0776, and SMu1870 all predicted transcriptional regulators.","Tue Feb 26 11:05:48 2002","Wed Sep 13 11:21:31 2006","pdb1AL3 Cofactor Binding Fragment Of Cysb From Klebsiella A... 68 1e-012","SMU.1225","","Residues 3 to 62 (E-value = 4.2e-20) place SMu1120 in the HTH_1 family which is described as Bacterial regulatory helix-turn-helix protein, lysR family (PF00126)Residues 85 to 299 (E-value = 7.2e-05) place SMu1120 in the LysR_substrate family which is described as LysR substrate binding domain (PF03466)","Wed Sep 13 11:21:31 2006","24379649","","","Koskiniemi,S., Sellin,M. and Norgren,M.Identification of two genes, cpsX and cpsY, with putativeregulatory function on capsule expression in group B streptococciFEMS Immunol. Med. Microbiol. 21 (2), 159-168 (1998)PubMed: 9685006","","Tue Feb 26 11:04:41 2002","1","","","SMU.1225","386" "SMu1121","1167982","1167215","768","ATGACTGAACAAGAAACCTTAACTATCCTTTTGGATGTCTATGCTTATTATCAGGCTTACCAAATTGTAAAAGCCAGTCAGTTTTTTTCAGATGATATTATCTTTCTCTTAGAATTGTTAAAGGAAAGACGCGAGCTTAATGTTGATTTTCTCTTTCAGAACCAAGTGCACCTGCAAGAATTGGAACTGACTTATCACATTTCTCTCTTGGATAATGCTTATGAAGAAGAGCTTTTGGCTAACTATATCATGGATTTAGAAGCCAAGTTGCGCAATGATCATATTATTGATTTTGTCAGAAGTGTCAGTCCCATTTTGTATCGTTTATTGATGCGACTGATGCAAAGTCAAGTAGCAGATATTAATGATTATATTTATGATGCTAAAAATGATCAATACGATACTTGGAAGTTTGACAAGATGCATGACTCTGCCAACCCCTTTGTTCAAAACTTTGTTGCTAAGGGAAGAGACAGCAAGATTACTTCAAGAAGTCTGGCGGATTTTATTCAGTTAACTGATTTGCCTCAGGCTATTAAAGACAACATTTTGCTTTTAAGAGATTTTGAAAAATCAGTACGAAATCCTCTGGCTCATCTTATCAAACCTTTTGATGAAGAAGAGCTTCATCGTACGACAGGCTTTTCTTCCCAAACCTTTTTGGAAAAAATCATTCAATTGGCTGTATTTTCTGGAATTCATTATGATAATGATAAGTTTTATTTTGACAAAGTGAATGAACTCATTAAGCGCATCTATCAGAATTAG","4.80","-12.30","30289","MTEQETLTILLDVYAYYQAYQIVKASQFFSDDIIFLLELLKERRELNVDFLFQNQVHLQELELTYHISLLDNAYEEELLANYIMDLEAKLRNDHIIDFVRSVSPILYRLLMRLMQSQVADINDYIYDAKNDQYDTWKFDKMHDSANPFVQNFVAKGRDSKITSRSLADFIQLTDLPQAIKDNILLLRDFEKSVRNPLAHLIKPFDEEELHRTTGFSSQTFLEKIIQLAVFSGIHYDNDKFYFDKVNELIKRIYQN","1167230","","histidine protein kinase ","Cytoplasm","Matches in gapped BLAST to histidine protein kinase and CpsIaS: residues 1-251 are 51% similar to histidine protein kinase from S.pyogenes (gi15674919) and residues 131-254 are 55% similar to CpsIaS from S.agalactiae (gi15186710).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1177 (9e-69).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 27 13:33:20 2007","Tue Mar 27 13:33:20 2007","Tue Mar 27 13:33:20 2007","Tue Feb 26 11:18:07 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1121 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 27 13:33:20 2007","","No significant hits to the NCBI PDB database.","SMU.1226c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 11:18:07 2002","24379650","","","","","","1","","","SMU.1226c","" "SMu1122","1168688","1167984","705","ATGTCTATTCATATTGGAGCCCAAGTGGGTCAAATTGCTGATAAAATTTTACTTCCGGGTGATCCTCTTCGTGCTAAATTCATTGCAGAAAATTTTCTTGAAGATGCGGTGTGTTTTAACGAAGTTCGTGGCATGCTTGGATTTACGGGAATTTATAAAGGTCATCGCGTTTCTGTTATGGGAACTGGCATGGGCATGCCTTCTATCTCAATTTATGTGAATGAGCTCATTCGTTCTTATGGTGTTAAAAAATTAATTCGTGTTGGAACAGCAGGTTCGCTTAACAAGGATGTCCATGTGCGTGATCTCGTTTTGGCGCAGGCTGCAGGGACAACTTCCAGCATGATTAAAAACGAATGGCCACAATACGATTTTCCGCAGATTGCTGATTTCTCAATGCTTGATAAGGCTTATCATATTGCTGAGGATATGGAGCTGACAACACATGTGGGAAGTGTTCTGTCTATTGATGCTTTTTATTCAGATTTTGCTGACAACAATATTAAGCTTGGACAAATTGGGGTTAAAGCCGTTGAAATGGAAGCGGCAGCTATTTATTATTTGGCTGCTAAACATGGTGTCCAAGCTTTGGGAATTATGACCATTTCAGACAGTTTAGTTGCTGACGAAGATACAACAGCTGAGGAACGCCAAACAACCTTTACTGACATGATGAAGGTAGGTTTAGAAACTTTAATTGCTTAA","4.90","-8.60","25460","MSIHIGAQVGQIADKILLPGDPLRAKFIAENFLEDAVCFNEVRGMLGFTGIYKGHRVSVMGTGMGMPSISIYVNELIRSYGVKKLIRVGTAGSLNKDVHVRDLVLAQAAGTTSSMIKNEWPQYDFPQIADFSMLDKAYHIAEDMELTTHVGSVLSIDAFYSDFADNNIKLGQIGVKAVEMEAAAIYYLAAKHGVQALGIMTISDSLVADEDTTAEERQTTFTDMMKVGLETLIA","1167999","For other 'deo' genes see SMu1026 (deoC) and SMu1128 (deoB).","purine-nucleotide phosphorylase","Cytoplasm","Several matches in gapped BLAST to purine-nucleotide phosphorylase :residues 1-234 are 79% similar to the enzyme in S.salivarius (gi11595686) and are 78% similar to the protein from S.pneumoniae (gi15902782).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1178 (1e-101).","

InterPro
IPR000845
Family

Nucleoside phosphorylase
PF01048	$\"[14-232]T$	PNP_UDP_1
PS01232	$\"[61-76]T$	PNP_UDP_1

InterPro
IPR004402
Family

Purine nucleoside phosphorylase
TIGR00107	$\"[4-234]T$	deoD

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1580	$\"[1-232]T$	G3DSA:3.40.50.1580
PTHR21234	$\"[1-234]T$	PTHR21234
PTHR21234:SF7	$\"[1-234]T$	PTHR21234:SF7
SSF53167	$\"[1-234]T$	SSF53167

","BeTs to 5 clades of COG0813COG name: Purine-nucleoside (and uridine) phosphorylaseFunctional Class: FThe phylogenetic pattern of COG0813 is --------Eb-HUJgp-L---Number of proteins in this genome belonging to this COG is 2","***** IPB000845 (Purine and other phosphorylases, family 1) with a combined E-value of 5.2e-59. IPB000845A 19-30 IPB000845B 43-77 IPB000845C 150-160 IPB000845D 174-210","Residues 48-109 are 85% similar to a (PHOSPHORYLASE NUCLEOSIDASE COMPLETE PROTEOME) protein domain (PD003928) which is seen in Q9ET99_STRSL.Residues 1-34 are 88% similar to a (PHOSPHORYLASE PURINE NUCLEOSIDE) protein domain (PD411638) which is seen in Q9ET99_STRSL.Residues 128-230 are 39% similar to a (PHOSPHORYLASE GLYCOSYLTRANSFERASE) protein domain (PD407575) which is seen in DEOD_MYCPN.Residues 111-234 are 74% similar to a (PHOSPHORYLASE NUCLEOSIDE PURINE) protein domain (PD414982) which is seen in Q9ET99_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 13:14:19 2006","Tue Feb 26 11:24:03 2002","Wed Sep 13 13:14:19 2006","Tue Feb 26 11:24:03 2002","Tue Feb 26 11:24:03 2002","Tue Feb 26 11:24:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1122 is paralogously related (blast p-value < 1e-3) to SMu1485, a predicted 5'-methylthioadenosine / S-adenosylhomocysteine and SMu1929, a predicted conserved hypothetical protein (possible phosphorylase).","Wed Sep 13 13:14:19 2006","Wed Sep 13 13:14:19 2006","pdb1ECPA Chain A, Purine Nucleoside Phosphorylase >gi1633414... 227 1e-060","SMU.1227c","","Residues 14 to 232 (E-value = 5.3e-98) place SMu1122 in the PNP_UDP_1 family which is described as Phosphorylase family (PF01048)","Tue Feb 26 11:24:03 2002","","","","","","","1","","","SMU.1227c","387" "SMu1123","1169612","1168902","711","ATGAGAATTCATTTTATCCTTCACGAAACATTTGAGGCACCCGGTGCCTACTTAGCTTGGGCAGCTCTTCGTGGTCACGACGTATCTATGACTAAGGTTTATCGTTATGAAAAGCTTCCTAAAGACATTGATGACTTTGATATGTTAATTCTTATGGGAGGACCTCAAAGTCCTTCCAGTACGAAAAAAGAATTTCCTTATTACGACGCCCAAGCAGAAGTTAAATTAATTCAAAAGGCTGCTAAGTCTGAGAAAATCATTGTTGGCGTCTGTCTGGGTGCTCAATTGATGGGAGTAGCTTATGGTGCAGATTATTTGCATAGTCCTAAAAAAGAAATTGGCAATTACTTGATTTCTTTGACAGAAGCTGGGAAAATGGATTCTTATTTAAGCGATTTTTCAGATGACTTGCTTGTTGGTCATTGGCATGGAGATATGCCTGGTTTGCCAGATAAGGCTCAAGTTTTGGCCATCAGTCAGGGCTGTCCTAGACAAATTATTAAATTTGGTCCTAAGCAATACGCTTTTCAATGTCATTTGGAATTTACACCTGAATTGGTCGCTGCCTTAATTGCGCAAGAAGATGATTTGGATACTCAAAGTCAAACAGAAACTTATGTACAGACAGCTGAGGAAATGCAGACCTTTGATTACTCGTCAATGAATCAAGCCTTGTATTCATTTTTGGATCGACTGACAGAAAGAAAATAA","4.90","-9.45","26579","MRIHFILHETFEAPGAYLAWAALRGHDVSMTKVYRYEKLPKDIDDFDMLILMGGPQSPSSTKKEFPYYDAQAEVKLIQKAAKSEKIIVGVCLGAQLMGVAYGADYLHSPKKEIGNYLISLTEAGKMDSYLSDFSDDLLVGHWHGDMPGLPDKAQVLAISQGCPRQIIKFGPKQYAFQCHLEFTPELVAALIAQEDDLDTQSQTETYVQTAEEMQTFDYSSMNQALYSFLDRLTERK","1168917","For other 'gat' genes see SMu1657 (gatB); SMu1658 (gatA); SMu1659 (gatC) and SMu1660 (gatA).","glutamine amidotransferase ","Cytoplasm","Matches in gapped BLAST to conserved hypotheticals: residues 1-155 are 52% similar to gi507928 Orf170 [Salmonella typhimurium]. Residues 1-191 are 36% similar to D64006, hypothetical protein [Synechocystis sp.]. SMu1123 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000991
Domain

Glutamine amidotransferase class-I
PF00117	$\"[12-197]T$	GATase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.880	$\"[1-231]T$	G3DSA:3.40.50.880
SSF52317	$\"[1-235]T$	SSF52317

","BeTs to 9 clades of COG0518COG name: GMP synthase - Glutamine amidotransferase domainFunctional Class: FThe phylogenetic pattern of COG0518 is AmtkYqVCebrHuj--o--n-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 140-234 are 57% similar to a (DOMAIN OF UNKNO N) protein domain (PD279105) which is seen in Q9EUP8_STRTR.Residues 1-124 are 60% similar to a (TRANSFERASE GLUTAMINE PROTEOME COMPLETE) protein domain (PD349562) which is seen in Q9EUP9_STRTR.Residues 139-191 are 43% similar to a (PROTEOME COMPLETE TRANSFERASE GMP) protein domain (PD095787) which is seen in Q55488_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 14:55:52 2007","Thu Mar 1 10:56:21 2007","Thu Mar 1 10:56:21 2007","Tue Feb 26 13:06:10 2002","","Tue Feb 26 13:06:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1123 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:06:10 2002","","No significant hits to the NCBI PDB database.","SMU.1228c","","Residues 12 to 197 (E-value = 1.1e-05) place SMu1123 in the GATase family which is described as Glutamine amidotransferase class-I (PF00117)","Tue Feb 26 13:06:10 2002","24379652","","","","","","1","","","SMU.1228c","" "SMu1124","1170431","1169622","810","ATGTCATTACTTAAAAAAATTTATGAAACACGTGATTTTCTAACAGCAAAAGGAGTCCAAAAGCCAGAATTCGGTCTCATTCTAGGTTCTGGTCTTGGTGAATTAGCTGAAGAAATTGAAAATGCTCTTGTCCTTAACTATGCTGACATCCCTAACTGGGGACGCTCGACAGTTTCCGGTCATGCTGGTAAACTTATTTATGGTGAATTAGCAGGTCGTAAAGTTTTGGCCTTGCAGGGACGTTTTCATTATTATGAAGGAAATTCTATGGAGCTTGTAACCTTCCCAATTCGTATTATGAAAGCACTTGGCTGTCAGGGACTTATCGTCACTAATGCGGCTGGCGGAATTGGCTTTGGTCCGGGAACTTTAATGGCTATTTCAGATCACATCAATCTGACAGGAGCCAATCCTTTGATGGGGGAAAATCTTGATGATTTTGGATTTCGTTTTCCTGATATGTCCAATGCTTATACAGCAGATTATCGTGAGGTTGCTCACCAAGTTGCAGATAAGATTGGGATCAAGTTAGATGAGGGTGTTTACATCGGTGTTTCTGGTCCATCCTATGAAACGCCTGCTGAAATCCGAGCTTTCAAGACTCTTGGAGCTGATGCAGTTGGTATGTCAACAGTACCAGAAGTTATCGTAGCTGTACATTCAGGTCTTAAGGTTTTGGGTATTTCTGCCATTACGAACTATGCAGCTGGTTTTCAATCGGAACTCAATCATGAAGAAGTTGTTGCAGTGACACAGCAGATAAAAGAAGATTTTAAGGGACTGGTAAAAGCTATTTTAGTAGAATTATAA","5.10","-7.59","28837","MSLLKKIYETRDFLTAKGVQKPEFGLILGSGLGELAEEIENALVLNYADIPNWGRSTVSGHAGKLIYGELAGRKVLALQGRFHYYEGNSMELVTFPIRIMKALGCQGLIVTNAAGGIGFGPGTLMAISDHINLTGANPLMGENLDDFGFRFPDMSNAYTADYREVAHQVADKIGIKLDEGVYIGVSGPSYETPAEIRAFKTLGADAVGMSTVPEVIVAVHSGLKVLGISAITNYAAGFQSELNHEEVVAVTQQIKEDFKGLVKAILVEL","1169637","From Genbank:[gi:2494052] This enzyme is involved in the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.","purine nucleoside phosphorylase","Cytoplasm","Several matches in gapped BLAST to purine nucleoside phosphorylase: residues 1-269 are 79% similar to the enzyme in S.pyogenes (gi|15674917|) and are 78% similar to the protein from S.thermophilus (gi|12054916|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1180 (1e-125).","

InterPro
IPR001369
Family

Purine phosphorylase, family 2
PTHR11904	$\"[6-269]T$	Mtap_PNP
PF00896	$\"[21-269]T$	Mtap_PNP

InterPro
IPR011268
Family

Inosine guanosine and xanthosine phosphorylase
PIRSF000477	$\"[3-269]T$	PurNPase
TIGR01697	$\"[23-267]T$	PNPH-PUNA-XAPA

InterPro
IPR011270
Family

Purine nucleoside phosphorylase I, inosine and guanosine-specific
TIGR01700	$\"[23-267]T$	PNPH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1580	$\"[5-269]T$	G3DSA:3.40.50.1580
PTHR11904:SF9	$\"[6-269]T$	PTHR11904:SF9
SSF53167	$\"[3-269]T$	SSF53167

","BeTs to 11 clades of COG0005COG name: Purine nucleoside phosphorylaseFunctional Class: FThe phylogenetic pattern of COG0005 is amtKYqVcebR----------Number of proteins in this genome belonging to this COG is 1","***** IPB001369 (Purine and other phosphorylases family 2) with a combined E-value of 3.6e-31. IPB001369A 22-35 IPB001369B 53-63 IPB001369C 179-219","Residues 3-184 are 76% similar to a (PHOSPHORYLASE PURINE NUCLEOSIDE) protein domain (PD006911) which is seen in Q9EUQ1_STRTR.Residues 185-248 are 84% similar to a (PHOSPHORYLASE GLYCOSYLTRANSFERASE PURINE NUCLEOSIDE) protein domain (PD003195) which is seen in Q9EUQ1_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 13:12:57 2002","Tue Feb 26 13:10:34 2002","Thu Oct 17 14:28:39 2002","Tue Feb 26 13:08:51 2002","Tue Feb 26 13:08:51 2002","Tue Feb 26 13:08:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1124 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:10:34 2002","Tue Feb 26 13:08:51 2002","pdb|1FXU|A Chain A, Purine Nucleoside Phosphorylase From Calf S... 233 3e-062pdb|1A9Q| Bovine Purine Nucleoside Phosphorylase Complexed W... 233 3e-062pdb|1A9P| Bovine Purine Nucleoside Phosphorylase Complexed W... 233 3e-062","SMU.1229c","","Residues 21 to 269 (E-value = 1.1e-101) place SMu1124 in the Mtap_PNP family which is described as Phosphorylase family 2 (PF00896)","Tue Feb 26 13:08:51 2002","","","","","","","1","","","SMU.1229c","388" "SMu1125","1170918","1170442","477","ATGGATAATAAAATGAAGTCAGAAGCAATTTTGTCAGTAGATAGGAAGTATCGTTACGTTCTTACTAGAACATGGGATGAAACTTTGCCTAATATTATGTTTGTTGGGCTAAATCCCTCTACAGCCGATGAAACAACAGATGATCCGACAATTAGGCGTTGTATCAACTTTGCTAAATCATGGGGATATGGTGGGCTATATATGGTTAATCTTTTTGCTTATCGTAGCACTAATCCCAACAATATACGAATAGTTGATAACCCTATTGGTGATAATAATGATAGTTATATCTCACATTACGCTAAATTATCAGATAAGGTTGTCGCTTGTTGGGGAAATCGTGGTTCTTACCAAAAGCGCTCAAAAGAAGTGACCAACTTACTAGAAGAAATATATTGTTTTGGGCAAAATAAGAGTGGCGAACCAAAGCATCCACTTTATTTGAAAAAAGAAATTTCACTCATTAAATATAAATAA","9.60","5.33","18261","MDNKMKSEAILSVDRKYRYVLTRTWDETLPNIMFVGLNPSTADETTDDPTIRRCINFAKSWGYGGLYMVNLFAYRSTNPNNIRIVDNPIGDNNDSYISHYAKLSDKVVACWGNRGSYQKRSKEVTNLLEEIYCFGQNKSGEPKHPLYLKKEISLIKYK","1170457","","conserved hypothetical protein","Periplasm, Extracellular","Matches in gapped BLAST to hypotheticals:residues 33-151 are 54% similar to hypothetical protein from S.thermophilus (gi|15485435|)Residues 5-155 are 51% similar to the protein from E.coli (gi|15804863|).SMu1125 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR012441
Family

Protein of unknown function DUF1643
PF07799	$\"[18-146]T$	DUF1643

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-120 are 33% similar to a (N043 ORF) protein domain (PD358013) which is seen in Q9KX75_STAAU.Residues 8-158 are 22% similar to a (PROTEOME COMPLETE NMB1020) protein domain (PD339487) which is seen in Q9JZJ8_NEIMB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 13:17:17 2002","Tue Feb 26 13:17:17 2002","Tue Feb 26 13:17:17 2002","Tue Feb 26 13:17:17 2002","","Tue Feb 26 13:17:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1125 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:17:17 2002","","No significant hits to the NCBI PDB database.","SMU.1230c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 13:17:17 2002","24379654","","","","","","1","","","SMU.1230c","" "SMu1126","1171132","1171037","96","ATGGATAAAAAAAGAGTTATTGAGCGTATCAAATCTTTTTCTCTGAGAGATGAAGTGATTCATTTTGGAGAATTGTGTATTTACTGGGGCAAATAA","9.40","2.17","3780","MDKKRVIERIKSFSLRDEVIHFGELCIYWGK","1171052","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.SMu1126 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 13:18:38 2002","Tue Feb 26 13:18:38 2002","Tue Feb 26 13:18:38 2002","Tue Feb 26 13:18:38 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1126 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:18:38 2002","","No significant hits to the NCBI PDB database.","SMU.1231c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 13:18:38 2002","24379655","","","","","","1","","","SMU.1231c","" "SMu1127","1171456","1171241","216","ATGGGAAATTATGTCGTCCTCTTAAGAGGTGTCAATGTTGGTGGCAAGAATAAGCTTGTGATGAGCGATCTTCGCCAGCAGGTAACCGATATGGGATTTGTCAATGTCAAAACCTATATCAATAGTGGCAATCTCTTCTTTCAGTCGGATTGTCCTCGTGCGAACATCAGTTCTCGGTTTGAACAATTCTTTGCAGACCATTATCCCTTTGTCTAG","9.40","2.17","8065","MGNYVVLLRGVNVGGKNKLVMSDLRQQVTDMGFVNVKTYINSGNLFFQSDCPRANISSRFEQFFADHYPFV","1171256","","conserved hypothetical protein","Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-71 are 53% similar to S.pneumoniae (gi|15902777|) and residues 4-65 are 48% similar to Sinorhizobium meliloti (gi|15964737|).SMu1127 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR012545
Family

Protein of unknown function DUF1697
PF08002	$\"[1-70]T$	DUF1697

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-70 are 37% similar to a (PROTEOME COMPLETE) protein domain (PD111523) which is seen in O06552_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 13:21:59 2002","Tue Feb 26 13:21:59 2002","Tue Feb 26 13:21:59 2002","Tue Feb 26 13:21:59 2002","","Tue Feb 26 13:21:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1127 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:21:59 2002","","No significant hits to the NCBI PDB database.","SMU.1232c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 13:21:59 2002","24379656","","","","","","1","","","SMU.1232c","" "SMu1128","1172669","1171458","1212","ATGTCAACTTTTAATCGTATTCATCTTGTTGTTTTAGACTCCGTTGGAATTGGGGCAGCACCCGATGCTAACAATTTCTCTAATGCTGGTGTTCCAGATGGTGCATCAGACACACTAGGACACATTTCAAAAACCGTTGGACTTAATGTGCCTAATATGGCTAAAATTGGTTTGGGAAATATCCCCCGTGATACGCCGCTTAAGACAGTTCCTGCGGAAAACCATCCAACTGGTTATGTTACAAAATTAGAAGAAGTCTCTTTAGGTAAAGATACGATGACCGGACACTGGGAAATCATGGGACTTAACATTACTGAACCTTTTGATACCTTCTGGAATGGTTTTCCCGAAGAAATCATCAGCAAAATTGAAAAATTTTCAGGGCGTAAGGTCATTCGTGAAGCTAATAAACCATACTCTGGTACAGCTGTTATTGATGACTTCGGTCCCCGTCAGATGGAGACTGGTGAATTGATTATCTATACGTCAGCTGACCCTGTTCTGCAAATTGCAGCACATGAGGATGTGATTCCACTTGATGAACTTTACCGTATTTGTGAATACGCGCGCAGCATTACCCTAGAACGTCCAGCTTTGCTTGGTCGTATCATTGCCCGTCCTTATGTCGGCAAGCCTAGGAATTTCACGCGGACAGCTAATCGTCATGATTATGCCCTATCGCCATTTGCACCAACAGTGTTGAATAAGTTAGCGGATGCGGGTGTTTCAACTTATGCTGTCGGTAAAATCAATGATATTTTCAATGGTTCAGGTATTACCAACGATATGGGACACAACAAATCAAACAGCCACGGTGTGGACACTTTGATTAAGACAATGGGCTTGTCTGCGTTCACCAAAGGTTTCTCGTTTACCAACTTGGTTGATTTTGATGCCCTTTATGGTCACCGTCGCAATGCACATGGTTATCGTGATTGTTTGCATGAGTTTGATGAACGCCTTCCAGAAATTATTGCAGCGATGAAAGTAGATGACTTGCTTTTGATTACAGCTGACCATGGTAATGACCCAACCTATGCGGGAACGGACCATACACGCGAATATGTTCCGCTTTTAGCTTACAGTCCATCATTTACTGGTAATGGAGTCCTACCTGTTGGTCATTACGCTGATATTTCAGCAACGATTGCTGATAACTTTGGTGTAGATACAGCTATGATTGGGGAGAGTTTCCTAGATAAATTAATATAA","5.40","-11.70","43944","MSTFNRIHLVVLDSVGIGAAPDANNFSNAGVPDGASDTLGHISKTVGLNVPNMAKIGLGNIPRDTPLKTVPAENHPTGYVTKLEEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEEIISKIEKFSGRKVIREANKPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEDVIPLDELYRICEYARSITLERPALLGRIIARPYVGKPRNFTRTANRHDYALSPFAPTVLNKLADAGVSTYAVGKINDIFNGSGITNDMGHNKSNSHGVDTLIKTMGLSAFTKGFSFTNLVDFDALYGHRRNAHGYRDCLHEFDERLPEIIAAMKVDDLLLITADHGNDPTYAGTDHTREYVPLLAYSPSFTGNGVLPVGHYADISATIADNFGVDTAMIGESFLDKLI","1171473","For other 'ppm' genes see SMu0590 (ppmA).For other 'deo' genes see SMu1026 (deoC) and SMu1122 (deod).","phosphopentomutase","Cytoplasm","Several matches in gapped BLAST to phosphopentomutase: residues 1-403 are 89% similar to the enzyme in S.pneumoniae (gi|15900716|) and are 85% similar to the protein from S.thermophilus (gi|12054915|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2069 (0.0).","

InterPro
IPR006124
Domain

Metalloenzyme
PF01676	$\"[266-377]T$	Metalloenzyme

InterPro
IPR010045
Family

Phosphopentomutase
PIRSF001491	$\"[4-403]T$	Ppentomutase
TIGR01696	$\"[6-397]T$	deoB

InterPro
IPR013553
Domain

Phosphopentomutase N-terminal
PF08342	$\"[6-101]T$	PPM_N

noIPR
unintegrated

unintegrated
PTHR21110	$\"[6-403]T$	PTHR21110
SSF53649	$\"[4-400]T$	SSF53649

","BeTs to 6 clades of COG1015COG name: Phosphopentomutase and related enzymesFunctional Class: GThe phylogenetic pattern of COG1015 is AMTk-qV-Eb--uj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002599 (Metalloenzyme superfamily) with a combined E-value of 7.9e-18. IPB002599B 255-265 IPB002599D 291-328 IPB002599E 331-344 IPB002599F 349-360","Residues 252-364 are 84% similar to a (MUTASE PHOSPHOGLYCERATE ISOMERASE) protein domain (PD004704) which is seen in Q9EUQ2_STRTR.Residues 244-299 are 64% similar to a (PHOSPHOPENTOMUTASE PROTEOME COMPLETE) protein domain (PD412191) which is seen in Q9CH12_LACLA.Residues 6-242 are 87% similar to a (PHOSPHOPENTOMUTASE PROTEOME ISOMERASE) protein domain (PD011687) which is seen in Q9EUQ2_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:29:45 2002","Tue Feb 26 13:24:20 2002","Thu Oct 17 14:29:45 2002","Tue Feb 26 13:24:20 2002","Tue Feb 26 13:24:20 2002","Tue Feb 26 13:24:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1128 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:24:44 2002","","No significant hits to the NCBI PDB database.","SMU.1233c","","Residues 266 to 377 (E-value = 2.4e-30) place SMu1128 in the Metalloenzyme family which is described as Metalloenzyme superfamily (PF01676)","Tue Feb 26 13:24:20 2002","","","","Hamamoto,T., Noguchi,T. and Midorikawa,Y.Phosphopentomutase of Bacillus stearothermophilus TH6-2: the enzyme and its gene ppmBiosci. Biotechnol. Biochem. 62 (6), 1103-1108 (1998)PubMed: 9692190","","Tue Feb 26 13:28:39 2002","1","","","SMU.1233c","195" "SMu1129","1173401","1172724","678","ATGGAAGAACTTAAAAAGATTGCTGGTGTTAGGGCAGCTCAATATGTTGAAGATGGTATGATTGTGGGACTTGGGACAGGTTCAACAGCCTATTATTTTGTTGAAGAAGTCGGTCGCCGTGTGCAAGAAGAGGGCTTGCAAGTGATTGGTGTGACGACGTCAAGTCGGACAACTGCTCAAGCTCAAGCTTTAGGTATTCCTCTCAAATCTATTGATGAGGTTGACTCTGTTGATGTGACAGTGGATGGAGCTGATGAGGTTGATCCTAATTTCAATGGTATTAAAGGCGGCGGTGGTGCTCTGCTGATGGAAAAGATAGTAGGAACATTGACAAAAGACTATATCTGGGTGGTTGATGAAAGCAAGATGGTTGATACTTTGGGAGCCTTTAGGTTACCCGTTGAAGTAGTTCAATATGGTGCTGAGCGTCTTTTTCGAGAGTTTGAGAAAAAAGGCTATAAACCTTCTTTTCGCGAATATGATGGTGTTCGCTTTGTGACTGACATGAAAAACTTTATCATTGATTTGGATTTGGGCTCTATCCCTGATCCTATTGCTTTTGGCAATATGTTAGATCATCAAGTCGGTGTTGTTGAACACGGCCTCTTCAATGGTATGGTTAATCGTGTGATTGTTGCAGGTAAAGATGGTGTTCGTATTTTGGAAGCTAATAAATAA","4.60","-10.50","24554","MEELKKIAGVRAAQYVEDGMIVGLGTGSTAYYFVEEVGRRVQEEGLQVIGVTTSSRTTAQAQALGIPLKSIDEVDSVDVTVDGADEVDPNFNGIKGGGGALLMEKIVGTLTKDYIWVVDESKMVDTLGAFRLPVEVVQYGAERLFREFEKKGYKPSFREYDGVRFVTDMKNFIIDLDLGSIPDPIAFGNMLDHQVGVVEHGLFNGMVNRVIVAGKDGVRILEANK","1172739","","ribose 5-phosphate isomerase A","Cytoplasm","Several matches in gapped BLAST to ribose 5-phosphate isomerase: residues 1-223 are 70% similar to the enzyme in S.pyogenes (gi15674914). Residues 1-225 are 66% similar to the protein from S.pneumoniae (gi15900715).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1183 (6e-85).","

InterPro
IPR004788
Family

Ribose 5-phosphate isomerase
PD005813	$\"[7-127]T$	RpiA
PTHR11934	$\"[2-225]T$	RpiA
PF06026	$\"[48-219]T$	Rib_5-P_isom_A
TIGR00021	$\"[4-219]T$	rpiA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1360	$\"[1-146]T$	G3DSA:3.40.50.1360
SSF100950	$\"[1-148]T$	SSF100950
SSF75445	$\"[128-203]T$	SSF75445

","BeTs to 10 clades of COG0120COG name: Ribose 5-phosphate isomeraseFunctional Class: GThe phylogenetic pattern of COG0120 is amtky--ce--h----olin-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-168 are 53% similar to a (ISOMERASE 5-PHOSPHATE RIBOSE) protein domain (PD005813) which is seen in RPIA_LACLA.Residues 169-221 are 73% similar to a (ISOMERASE 5-PHOSPHATE RIBOSE PROTEOME) protein domain (PD399429) which is seen in Q9EUQ3_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 13:41:22 2002","Wed Aug 30 15:34:32 2006","Wed Aug 30 15:34:32 2006","Tue Feb 26 13:38:14 2002","","Tue Feb 26 13:38:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1129 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:41:22 2002","","No significant hits to the NCBI PDB database.","SMU.1234c","","Residues 48 to 219 (E-value = 1.8e-98) place SMu1129 in the Rib_5-P_isom_A family which is described as Ribose 5-phosphate isomerase A (phosphoriboisomerase A) (PF06026)","Tue Feb 26 13:38:14 2002","","","","","","","1","","","SMU.1234c","571" "SMu1130","1173530","1174897","1368","ATGATAACAAATGAATTTGATACTATTACTGCTATCGCTACACCTCTTGGCGAAGGGGCAATCGGCATCGTCCGTATTTCAGGATCGAAAGCACTAGCTATTATTAAAAAGATTTTTAAGGGAAAAAATTTGGATGATGTTCCCTCCCATACCATTAATTACGGACATATTGTTGAGAATGGGGCAATCATTGATGAAGTGATGGTCTCAGTCATGCGCGCTCCAAAAACGTTCACACGTGAAGATGTGATTGAAATCAATACGCATGGCGGTGTGGCTGTCACCAATGAAATCCTGCAGTTGGTTCTCCGCTCTGGTGCTCGTATGGCAGATCCCGGTGAATTTACCAAGCGTGCCTTTCTCAATGGACGTGTTGATTTAGCGCAAGCTGAAGCTGTAATGGATCTCATTCGCGCCAAAACAGACAAAGCCATGGCTGTTGCCGTTCAACAACTGGATGGCTCCCTTTCAAATCTTATCAATAACACACGTCAGGAAATTCTCAATACTCTGGCCCAAGTTGAGGTTAACATTGACTATCCTGAGTATGATGATGTGGAAGAAATGACGACAGCACTCATGCGAGAGAAGACTCAGGAATTCGAAACCCTCTTAACCAATCTTTTAAAGACAGCCCGCCGCGGGAAAATTTTGCGTGAAGGCTTATCTACTGCTATCATTGGACGTCCCAATGTTGGCAAATCCAGTCTGCTCAACAATCTTTTACGAGAAGAAAAAGCTATCGTTACTGATATTGAAGGGACAACTCGCGATGTCATTGAAGAGTATGTCAATATCAAGGGTGTTCCTCTCAAACTGATTGATACGGCTGGTATTCGTGAAACTGATGATCTGGTTGAAAAAATTGGAGTGGAACGGTCTAAAAAAGCTTTAGAAGAAGCTGATCTGGTCTTACTCGTTCTCAACAGTGCTGAGAAACTGACTGATCAAGATCGAACTCTTTTAGAAATCAGCCAAAACAGCAACCGTCTTATCCTTCTTAATAAGACAGACCTCCCAGAGCAAATTGAAACGGATCAGCTTCCAGAAGATTGCATCAAAATCTCTGTCATCAAAAACCAGAATATTGATGTCATTGAAGAGCGCATCAATAAGCTTTTCTTTGATAATGCCGCCATTGTCGAAAAAGATGCCACCTATCTATCCAATGCCCGCCATATTTCCTTAATTGAAAAAGCTCTTAAAAGTCTACAGGCCGTTAATGACGGTCTGGAACTCGGCATGCCTGTTGATCTCTTGCAAGTTGATATGACGCGAACTTGGGAAATTCTTGGTGAGATTACTGGTGATGCAGCGCCAGATGAACTCATTACACAACTCTTTAGCCAGTTTTGTTTGGGGAAATAA","4.60","-21.07","50343","MITNEFDTITAIATPLGEGAIGIVRISGSKALAIIKKIFKGKNLDDVPSHTINYGHIVENGAIIDEVMVSVMRAPKTFTREDVIEINTHGGVAVTNEILQLVLRSGARMADPGEFTKRAFLNGRVDLAQAEAVMDLIRAKTDKAMAVAVQQLDGSLSNLINNTRQEILNTLAQVEVNIDYPEYDDVEEMTTALMREKTQEFETLLTNLLKTARRGKILREGLSTAIIGRPNVGKSSLLNNLLREEKAIVTDIEGTTRDVIEEYVNIKGVPLKLIDTAGIRETDDLVEKIGVERSKKALEEADLVLLVLNSAEKLTDQDRTLLEISQNSNRLILLNKTDLPEQIETDQLPEDCIKISVIKNQNIDVIEERINKLFFDNAAIVEKDATYLSNARHISLIEKALKSLQAVNDGLELGMPVDLLQVDMTRTWEILGEITGDAAPDELITQLFSQFCLGK","1174906","","thiophene and furan oxidation protein; tRNA modification GTPase","Cytoplasm","Matches in gapped BLAST to thiophene degradation protein F: residues 225-338 are 31% and residues 223-341 are 32% similar to the previously published enzyme phosphoglycerate dehydrogenase in S.mutans (gi6681650). Residues 1-450 are 71% similar to thiophene degradation protein in S.pyogenes (gi15675063).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0876 (0.0).","

InterPro
IPR001806
Family

Ras GTPase
PR00449	$\"[222-243]T$ $\"[262-284]T$ $\"[326-339]T$	RASTRNSFRMNG

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[222-338]T$	MMR_HSR1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[220-385]T$	AAA

InterPro
IPR004520
Family

tRNA modification GTPase TrmE
TIGR00450	$\"[13-455]T$	thdF

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[219-372]T$	small_GTP

InterPro
IPR005289
Domain

GTP-binding
TIGR00650	$\"[227-278]T$	MG442

noIPR
unintegrated

unintegrated
G3DSA:3.30.1360.120	$\"[6-124]T$	G3DSA:3.30.1360.120
G3DSA:3.40.50.300	$\"[215-379]T$	G3DSA:3.40.50.300
PTHR11649	$\"[47-455]T$	PTHR11649
PTHR11649:SF15	$\"[47-455]T$	PTHR11649:SF15
SSF52540	$\"[76-372]T$	SSF52540

","BeTs to 12 clades of COG0486COG name: Predicted GTPases, ThdF familyFunctional Class: RThe phylogenetic pattern of COG0486 is ----yqvceb-hujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000765 (GTP1/OBG family) with a combined E-value of 9.9e-14. IPB000765 222-265","Residues 309-374 are 65% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in TRME_STRAG.Residues 8-198 are 75% similar to a (GTP-BINDING TRNA GTPASE TRNA-PROCESSING) protein domain (PD004624) which is seen in TRME_LACLA.Residues 388-455 are 94% similar to a (GTP-BINDING TRNA GTPASE TRNA-PROCESSING) protein domain (PD006570) which is seen in TRME_STRAG.Residues 285-377 are 30% similar to a (GTP-BINDING TRME TRNA GTPASE) protein domain (PD394171) which is seen in TRME_BACHD.Residues 227-287 are 93% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in TRME_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 13:52:07 2002","Tue Aug 1 17:01:23 2006","Tue Aug 1 17:01:23 2006","Tue Feb 26 13:48:00 2002","Tue Feb 26 13:48:00 2002","Tue Feb 26 13:48:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1130 is paralogously related (blast p-value < 1e-3) to SMu1744, a predicted phosphoglycerate dehydrogenase; SMu1471 and SMu0903 both predicted GTP-binding proteins.","Tue Feb 26 13:53:39 2002","","No significant hits to the NCBI PDB database.","SMU.1235","","Residues 116 to 376 (E-value = 3.1e-08) place SMu1130 in the MMR_HSR1 family which is described as GTPase of unknown function (PF01926)","Tue Feb 26 13:48:00 2002","24379659","","","Zabel MD, Bunch PK, Clark DP.Regulation of the thdF gene, which is involved in thiophene oxidation by Escherichia coli K-12.Microbios. 2000;101(399):89-103.PMID: 10738982 Alam KY, Clark DP.Molecular cloning and sequence of the thdF gene, which is involved in thiophene and furan oxidation by Escherichia coli.J Bacteriol. 1991 Oct;173(19):6018-24.PMID: 1917835","Tue Apr 2 17:54:05 2002","Sun Nov 10 16:03:40 2002","1","","","SMU.1235","101" "SMu1131","1175848","1175045","804","ATGATTATTGATAATATCCAGCATGTTATGTTTCCAATAGCAGCGCAGGTTGAAAAACTGGAGAAAGCAAAAGTTGATAAAGCTATTTTATTTTGTACGACACCGCATCCTGAAAGAGCTCGTTCCTATAAAGAACTAAAAGAAGAGATGTCAATACTATTTAAAGTTCTAAGTGGAGATGGACTGCAGGTTGTTTCACTAGACAGAATGAAACAAAATAATCAAAAAGTTGTGCAAGCGATTCAAAAGTATCCGCAAAAGTTTTATGGCTTTGGTTCTGTTCCGCTTGGTTTATCTTTAAATGATACTATTGATTGGATCGAAGAACAAATTGTAAGAAATGGTTTGAAAGGCTTAGGAGAGTTTACTCCCGGTTCAGATGAACAGGTTGGACAATTAGAAACTATTTTCCAAGCGTTAGCTAAATTTCCTAGTTTACCTGTTTGGGTACATACTTTTAATCCAGTCAGTTTAAAAGGCATCCAAACTTTGATGAACTTAACAAAAAAATACCCTCATATTTCTGTAATCTTTGGACATATGGGAGGGTATTATTGGATGAATGTTATTGATTTTGTCAAAGAAACGCCAAATGCTTTTATTGACTTATCTGGAACCTTCTCTACTTTGGCTGTAAGGATGGCTATCACTGAAATTCCTCAAAAATGTTTATTTGGTTCTGACGCTCCTTATGGAGAACCCTTTATGAGTAAGGAATTGGTTGAATACTTGGCACCTACTGATACTATTAGAGATATGGTATTGGGAGGAAATATTCAAAAATTGTTAGAGCTGTCTAATTAA","6.40","-1.88","30021","MIIDNIQHVMFPIAAQVEKLEKAKVDKAILFCTTPHPERARSYKELKEEMSILFKVLSGDGLQVVSLDRMKQNNQKVVQAIQKYPQKFYGFGSVPLGLSLNDTIDWIEEQIVRNGLKGLGEFTPGSDEQVGQLETIFQALAKFPSLPVWVHTFNPVSLKGIQTLMNLTKKYPHISVIFGHMGGYYWMNVIDFVKETPNAFIDLSGTFSTLAVRMAITEIPQKCLFGSDAPYGEPFMSKELVEYLAPTDTIRDMVLGGNIQKLLELSN","1175060","","conserved hypothetical protein (possible dihydroorotase family)","Cytoplasm","Matches in gapped BLAST to amidohodrolase and hypothetical proteins:residues 1-265 are 40% similar to Clostridium acetobutylicum (gi|15896580|ref|NP_349929.1) residues 73-234 are 25% similar to Pyrococcus abyssi (gi|14520316|) and are 26% similar to Pyrococcus horikoshii (gi|14590044|).SMu1131 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006992
Family

Amidohydrolase 2
PF04909	$\"[31-265]T$	Amidohydro_2

noIPR
unintegrated

unintegrated
SSF51556	$\"[1-265]T$	SSF51556

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 73-234 are 25% similar to a (PROTEOME COMPLETE VNG0297H PH0093) protein domain (PD119883) which is seen in Q9V2H6_PYRAB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed May 1 15:22:55 2002","Thu Oct 17 14:46:43 2002","Thu Oct 17 14:32:45 2002","Tue Feb 26 14:04:44 2002","","Tue Feb 26 14:04:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1131 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 14:04:44 2002","","No significant hits to the NCBI PDB database.","SMU.1236c","","Residues 1 to 265 (E-value = 1.5e-20) place SMu1131 in the Amidohydro_2 family which is described as Amidohydrolase (PF04909)","Wed May 1 15:37:01 2002","24379660","","","","","","1","","","SMU.1236c","" "SMu1132","1176216","1175866","351","ATGACAATACTTGAACACTATTTTTATTTATCTGATTTGGCAGTAACTGATAAAAGAAGTCTCCAGAAATTGTGCTGTCTCTTCAAAGATGATGCGATTATAGAGGCTAATGATGGGCATAGATATTCTGGAAGAAGAGAGATCGATTCATTTTTTACAGAATTTTTTAGTAGGAATGCTGAAACAAGACATTTATATGATATCCGAGAATTATCGGATACTGTTCAACAGGCCAACTGGGGAGTTGTTTGCAGAAGAAAAAATGGAGCATATATTGCCTTGACTGGTACCGATATTGCCGAGGTTGAAGACGGGAAAATCAGTCATTTAACCATTACTAGTAATAATTAG","5.60","-3.19","13338","MTILEHYFYLSDLAVTDKRSLQKLCCLFKDDAIIEANDGHRYSGRREIDSFFTEFFSRNAETRHLYDIRELSDTVQQANWGVVCRRKNGAYIALTGTDIAEVEDGKISHLTITSNN","1175881","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1132 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF54427	$\"[13-112]T$	SSF54427

InterPro
IPR005122
Family

Uracil-DNA glycosylase superfamily
PF03167	$\"[28-189]T$	UDG

noIPR
unintegrated

unintegrated
G3DSA:3.40.470.10	$\"[2-191]T$	G3DSA:3.40.470.10
SSF52141	$\"[3-193]T$	UDNA_glycsylseSF

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 25-185 are 71% similar to a (PROTEOME COMPLETE HI0220.2 YSID) protein domain (PD179728) which is seen in Y22A_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 14:11:05 2002","Tue Feb 26 14:11:05 2002","Tue Feb 26 14:11:05 2002","Tue Feb 26 14:11:05 2002","","Tue Feb 26 14:11:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1133 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 14:11:05 2002","","No significant hits to the NCBI PDB database.","SMU.1238c","","Residues 30 to 189 (E-value = 1.2e-07) place SMu1133 in the UDG family which is described as Uracil DNA glycosylase superfamily (PF03167)","Tue Feb 26 14:11:05 2002","24379662","","","","","","1","","","SMU.1238c","691" "SMu1134","1178809","1177397","1413","ATGTTTGTAGATTTTCAAAAAGAGGTAGATAAACGCCGCGGAGATATTTTGGCCGATTTGTTTCGGATTTTACAGATTAATTCTGAGCGTGATGACAGTAAGGCTGATAAAAAACATCCTTTTGGGCCCGGCCCTGTTCAAGCTCTTGAACATTTTTTGAAAATGGCAGAGCGTGATGGTTATGAGACTAAAAATGTTAATAACTATGCCGGTCATTTTGAATACGGTCAAGGAGATGAGGTCTTAGGCATTTTTGCCCATCTGGATGTGGTGCCAGCGGGTAGTGGCTGGAAAACCTCTCCTTATTTGCCAGAAATCATCAATGGCAAACTCTATGCGCGTGGTGCTAGTGATGACAAAGGCCCAACGATTGCCTGTTATTATGGTTTAAAAATTATTAAGGAATTAGGTTTACCAGTCTCTAAGAAAGTTCGTTTTGTTGTTGGTACTGATGAAGAGTCTGGTTGGGCTGATATGGATTATTATTTTGAACATGTTGACATGCCAGAGCCAGATTTTGGTTTTTCACCAGATGCTTATTTTCCAATTATCAATGGAGAAAAAGGGAATATTACGGAATACCTTCATTTTGGCAATAGCAATGGTGGTTCTTTTATCCTTAAATCTTTCAAAGGTGGGCTGCGTGAAAACATGGTACCAGAATCAGCAACAGCTGTTTTTTCAGCAACGATTTGTTTAGCTGAATTGCAAGAATCTTTGACCGCTTTTACAGAACAACATGCTTTAACAGCGGATCTTAAGGAAGAAGCAGGGAATTTTGTCTTGACCTTGCATGGCAAGTCTGCTCACGGTTCAACACCAGAAGCAGGTATCAATGGAGCTACTTATTTGGCACGCTTCTTGTCACAGTTTGATTTTGCTGGTGATGCTAAAGCTTACTTGGATTTAGCTGCCAATGTTTTATTAGATGATCATGCGGGTGAAAAACTGGGAGTTGCCTATAAGGATGAGAAGATGGGTTCTGTTTCCATGAATCCTGGCGTCTTTAGTTTTGATTCTCAATCTGAAGACAATAGCATTGCGCTTAATTTCCGCTATCCTCAAGGGACAGATGCACAGACCATCAAGGCCAGCCTAGAACAATTATCAGTATCAGGTGTTAGAGAGGTTACTCTGTCTGAGCATGAACAAAAACCCCATTATGTGCCGATGGATGATCCGTTAGTAGCTACCTTGCTAGCGGTTTATGAAAAACATACAGGAGATAAAGGGCATGAATGGGTTATCGGTGGTGGTACCTTTGGACGTTTGCTCAAGCGCGGAGTTGCTTTTGGCGCTATGTTCCCCCATTCGACAGATACCATGCATCAAGCTAATGAATTTGTTGAAGTGAACGATCTGTATAAAGCAGCTGCTATTTATGCAGAAGCCATTTATGAATTGATCAAATAG","4.90","-22.19","51680","MFVDFQKEVDKRRGDILADLFRILQINSERDDSKADKKHPFGPGPVQALEHFLKMAERDGYETKNVNNYAGHFEYGQGDEVLGIFAHLDVVPAGSGWKTSPYLPEIINGKLYARGASDDKGPTIACYYGLKIIKELGLPVSKKVRFVVGTDEESGWADMDYYFEHVDMPEPDFGFSPDAYFPIINGEKGNITEYLHFGNSNGGSFILKSFKGGLRENMVPESATAVFSATICLAELQESLTAFTEQHALTADLKEEAGNFVLTLHGKSAHGSTPEAGINGATYLARFLSQFDFAGDAKAYLDLAANVLLDDHAGEKLGVAYKDEKMGSVSMNPGVFSFDSQSEDNSIALNFRYPQGTDAQTIKASLEQLSVSGVREVTLSEHEQKPHYVPMDDPLVATLLAVYEKHTGDKGHEWVIGGGTFGRLLKRGVAFGAMFPHSTDTMHQANEFVEVNDLYKAAAIYAEAIYELIK","1177412","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). ","dipeptidase","Cytoplasm, Extracellular","Matches in gapped BLAST to dipeptidase:residues 85-164 are 36% similar to the previously published enzyme AtmC in S.mutans (gi15625430). Residues 3-453 are 70% similar to dipeptidase in S.pneumoniae (gi15902591).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1219 (0.0).","

InterPro
IPR001261
Family

ArgE/dapE/ACY1/CPG2/yscS
PS00758	$\"[82-91]?$	ARGE_DAPE_CPG2_1
PS00759	$\"[116-155]?$	ARGE_DAPE_CPG2_2

InterPro
IPR002933
Family

Peptidase M20
PF01546	$\"[83-467]T$	Peptidase_M20

InterPro
IPR010964
Family

Peptidase M20A, peptidase V
PTHR11014:SF6	$\"[12-232]T$ $\"[319-470]T$	Pept_M20A_pepV
TIGR01887	$\"[13-465]T$	dipeptidaselike

InterPro
IPR011291
Family

Peptidase M20A, dipeptidase PepV
TIGR01886	$\"[3-470]T$	dipeptidase

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.10	$\"[1-468]T$	G3DSA:3.40.630.10
PTHR11014	$\"[12-232]T$ $\"[319-470]T$	PTHR11014
SSF53187	$\"[1-468]T$	SSF53187
SSF55031	$\"[188-394]T$	SSF55031

","BeTs to 12 clades of COG0624COG name: Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylasesFunctional Class: EThe phylogenetic pattern of COG0624 is AM-KYqV-EBRHuj-----nxNumber of proteins in this genome belonging to this COG is 2","***** IPB001261 (ArgE/dapE/ACY1/CPG2/yscS family) with a combined E-value of 2.3e-06. IPB001261A 117-129 IPB001261B 144-153 IPB001261C 256-272","Residues 23-139 are 51% similar to a (COMPLETE PROTEOME HYDROLASE DESUCCINYLASE) protein domain (PD001449) which is seen in Q45631_BACST.Residues 140-453 are 62% similar to a (DIPEPTIDASE PROTEOME COMPLETE CARNOSINASE) protein domain (PD017739) which is seen in Q9CH96_LACLA.Residues 3-55 are 49% similar to a (DIPEPTIDASE PROTEOME COMPLETE CARNOSINASE) protein domain (PD257767) which is seen in Q9CH96_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 10 09:10:12 2006","Tue Feb 26 14:17:26 2002","Thu Aug 10 09:10:12 2006","Tue Feb 26 14:17:26 2002","Tue Feb 26 14:17:26 2002","Tue Feb 26 14:17:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1134 is paralogously related (blast p-value < 1e-3) to SMu1763, a predicted AtmC.","Tue Feb 26 14:22:12 2002","","No significant hits to the NCBI PDB database.","SMU.1239c","","Residues 20 to 470 (E-value = 7.8e-74) place SMu1134 in the Peptidase_M20 family which is described as Peptidase family M20/M25/M40 (PF01546)","Tue Feb 26 14:17:26 2002","","","","Hellendoorn,M.A., Franke-Fayard,B.M., Mierau,I., Venema,G. andKok,J.Cloning and analysis of the pepV dipeptidase gene of Lactococcuslactis MG1363J. Bacteriol. 179 (11), 3410-3415 (1997)PubMed: 9171382","","Tue Feb 26 14:20:29 2002","1","","","SMU.1239c","136" "SMu1135","1179426","1178824","603","ATGAAATTTTTAGAACTGAATAAAAAGCGCCATGCAACTAAGCATTTTAATGAAAAAGCAGTTGATTTTAAAGATGTTAGAACAGCCATTGAGATTGCCCAATTAGCTCCTAGTGCTCATAATATACAGCCTTGGAAGTTTGTCCTTGTTAAAGATAAAAAGGCAGCCTTGGCTGAAGACCTGCCTGCTTTAAATAAGGATCAGGTTGAAGGCGCACAGTATGTCATTGCTTTGTTTACCGACACCGACTTAGTTCAGCGTGCGCGCAAAATTGCACGTATTGGCAGCAAAAACCTGCCTGATGATATGATTGGTTATTTCATGGAAACTTTACCAGCTCGGTTTGCGGATTTTGATGAACAAACCAAAGGAGAATATTTGGCTTTAAATGCAGGTTTAGTAGCTATGAATCTGGTCTTGGCTCTAACTGACCAGGGCATTTCGTCTAATATTATTCTTGGTTTTGATAAGACGAAAACCAATACTATTTTAGATATTGATGAGCGTTTTCGCCCAGAACTCTTGATTACAGTTGGTTATACAGATGAGAAGATAGAACCAAGTTATCGTTTGCCGGTTGATGAAATTATTGAAGAAAGATAG","5.20","-4.27","22665","MKFLELNKKRHATKHFNEKAVDFKDVRTAIEIAQLAPSAHNIQPWKFVLVKDKKAALAEDLPALNKDQVEGAQYVIALFTDTDLVQRARKIARIGSKNLPDDMIGYFMETLPARFADFDEQTKGEYLALNAGLVAMNLVLALTDQGISSNIILGFDKTKTNTILDIDERFRPELLITVGYTDEKIEPSYRLPVDEIIEER","1178839","Many other 'nrd' genes have an unrelated function to nitroreductase.","nitroreductase family protein","Cytoplasm","Matches in gapped BLAST to NADH dehydrogenase and nitroreductase family protein: residues 1-200 are 76% similar to the NADH dehydrogenase in S.pyogenes (gi|15675061|) and are 71% similar to the protein from S.pneumoniae (gi|15900530|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1220 (2e-87).","

InterPro
IPR000415
Family

Nitroreductase
PF00881	$\"[7-180]T$	Nitroreductase

noIPR
unintegrated

unintegrated
G3DSA:3.40.109.10	$\"[1-200]T$	G3DSA:3.40.109.10
PIRSF000232	$\"[1-200]T$	NADHdh_nitroRD
PTHR23026	$\"[32-199]T$	PTHR23026
PTHR23026:SF43	$\"[32-199]T$	PTHR23026:SF43
SSF55469	$\"[1-200]T$	SSF55469

","BeTs to 7 clades of COG0778COG name: Nitroreductase family proteinsFunctional Class: CThe phylogenetic pattern of COG0778 is AmT--qVcEBRHUJ-------Number of proteins in this genome belonging to this COG is 3","***** IPB000415 (Nitroreductase family) with a combined E-value of 1.9e-10. IPB000415A 37-49 IPB000415B 137-155","Residues 8-51 are 52% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE NITROREDUCTASE RDXA) protein domain (PD001645) which is seen in Q9CJ26_LACLA.Residues 129-196 are 53% similar to a (OXIDOREDUCTASE COMPLETE PROTEOME) protein domain (PD036524) which is seen in Q9CJ26_LACLA.Residues 51-128 are 37% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD390463) which is seen in Q9CJ26_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:56:03 2002","Tue Feb 26 14:29:05 2002","Thu Oct 17 14:51:23 2002","Tue Feb 26 14:28:14 2002","Tue Feb 26 14:28:14 2002","Tue Feb 26 14:28:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1135 is paralogously related (blast p-value < 1e-3) to SMu0312, and SMu1457, both predicted nitroreductases.","Thu Mar 21 14:16:12 2002","Tue Feb 26 14:28:14 2002","pdb|1NOX| Nadh Oxidase From Thermus Thermophilus 74 1e-014","SMU.1240c","","Residues 7 to 180 (E-value = 1.5e-24) place SMu1135 in the Nitroreductase family which is described as Nitroreductase family (PF00881)","Tue Feb 26 14:28:14 2002","24379664","","","","","","1","","","SMU.1240c","" "SMu1136","1181360","1179573","1788","ATGAACGAACTGATTAAACATAAGCTGGAATTGCTGCCAGATAGTCCTGGCTGTTATATTCACAAGGATAAAAACGGCACCATTATCTATGTCGGTAAGGCCAAGAACTTAAAAAACCGTGTGCGCAGCTATTTTCACGGCAGCCATAATACCAAGACAGAATTGTTGGTTTCGGAAATTGAGGATTTTGAATACATTGTTACTGGGTCAAATACAGAAGCTTTACTTCTTGAGATTAATCTCATTCAGGAAAATAAGCCCAAGTACAATATCAGACTCAAAGATGATAAGTCTTATCCTTTTATTAAAATTACCAATGAACCTTATCCGCGTTTATTGATTACCCGTCAGGTGAAAAAGGATGGCGGTCTTTATTTTGGTCCCTACCCTGATTCGGGAGCTGCTACTGAAATTAAGCGACTTTTAGATCGTCTCTTTCCCTTTAAAAAATGCACCAACCCAGCCAACAAGGTCTGTTTTTATTATCATCTCGGGCAATGCAAGGCGCATACCATTTGTCAGACCGACCAAACCTATTGGGATAGTCTTAAAGAAGATGTGAAAAACTTTCTCAATGGCAGGGACGATAAGATTGTCAATGAACTGCGCGATAAAATGACCAAAGCTTCTGAGCTCATGGAATTTGAACGTGCAGCTGAATACCGAGATCTTATTGAGGGCATTGGTCTGTTGCGAACTAAGCAGCGCGTCATGAATCAGGATATGCAGGATCGTGATATTTTTGGTTATTATGTTGATAAAGGCTGGATGTGTGTGCAGGTTTTCTTTATTCGTCAGGGAAAGCTTATTCAGCGCGATGTCAATATGTTTCCTTATTACAATGAGTCTGAGGAAGATTTTCTGACCTATGTAGGACAGTTCTATCAGGATAACCGTCACTTTATTCCAAAGGAGATTTTTATTCCTAGAAATATTGATGAAACTTTGGTTAAAGCGGTGGTCAATACTAAGATTATCAAACCGCAGCGCGGCGAGAAGAAGCAGTTAGTCAATCTGGCAACGAAAAATGCTCGTGTTAGCCTGCAGCAGAAATTTGATCTCTTGGAAAAAGATATTCGAAAAACGCATGGTGCGATTGAAAATATTGGAGATTTACTTAATATTCCTAAGCCAGTGCGCATTGAAGCCTTTGATAATTCCAACATTCAAGGAACCAGTCCTGTTGCAGCTATGGTTGTTTTTGTGGACGGCAAGCCAAGTAAGAAGGATTATCGTAAATTTAAAATCAAAACCGTTATCGGACCTGATGACTATGCCAGCATGCGTGAGGTTATTTATCGCAGATATAGCCGTGTCATGCGAGATGGACTGACACCACCAGACCTGATTATTATTGATGGGGGACAAGGTCAGGTTAATGTAGCGCGTGACGTTATCGAAAATAAATTGGGACTCGATATTCCTATCGCTGGTTTGCAAAAAAATGATAAGCACCAAACCCATGAGCTGCTCTTTGGTGATCCGCTGGAAGTGATTCCTCTGCCTAGAAATTCAGAAGAGTTCTTTCTCTTGCAGCGCATTCAAGACGAAGTGCATCGCTTTGCCATTACATTTCATAGGCAGCTGCGCGGTAAAAACACCTTCTCATCAAAGTTGAACGGTATTGCAGGGCTCGGCCCTAAGCGCAAGCAATTGCTGATGAAACACTTTAAGAATCTTCCTAATATTCAAAAGGCCAGCCTAGATGATATTATCAACTGCGGCATTCCAAAAAATGTCGCAGAGAACATTCAAGAGAGCTTGCGAGAGGAAAGAGAAAAAGGTTAA","9.80","16.85","68883","MNELIKHKLELLPDSPGCYIHKDKNGTIIYVGKAKNLKNRVRSYFHGSHNTKTELLVSEIEDFEYIVTGSNTEALLLEINLIQENKPKYNIRLKDDKSYPFIKITNEPYPRLLITRQVKKDGGLYFGPYPDSGAATEIKRLLDRLFPFKKCTNPANKVCFYYHLGQCKAHTICQTDQTYWDSLKEDVKNFLNGRDDKIVNELRDKMTKASELMEFERAAEYRDLIEGIGLLRTKQRVMNQDMQDRDIFGYYVDKGWMCVQVFFIRQGKLIQRDVNMFPYYNESEEDFLTYVGQFYQDNRHFIPKEIFIPRNIDETLVKAVVNTKIIKPQRGEKKQLVNLATKNARVSLQQKFDLLEKDIRKTHGAIENIGDLLNIPKPVRIEAFDNSNIQGTSPVAAMVVFVDGKPSKKDYRKFKIKTVIGPDDYASMREVIYRRYSRVMRDGLTPPDLIIIDGGQGQVNVARDVIENKLGLDIPIAGLQKNDKHQTHELLFGDPLEVIPLPRNSEEFFLLQRIQDEVHRFAITFHRQLRGKNTFSSKLNGIAGLGPKRKQLLMKHFKNLPNIQKASLDDIINCGIPKNVAENIQESLREEREKG","1179588","For other 'uvr' genes see SMu0734 (uvrB) and SMu1686 (uvrA).For the subunit A sequence (uvrA) see SMu1686. For the subunit B sequence (uvrB) see SMu0734.From Genbank.[gi:13878835]This is a DNA repair enzyme that catalyzes the excision reaction of uv-damaged nucleotide segments producing oligomers having the modified bases.It attaches to the UVRA-UVRB complex, displacing UVRA, and the damaged DNA strand is nicked on both sides of the damaged site.","excinuclease ABC, subunit C","Cytoplasm","Several matches in gapped BLAST to excinuclease ABC (subunit C): residues 1-592 are 78% similar to the enzyme in S.pyogenes (gi15675060). Residues 1-593 are 76% similar to the protein from S.pneumoniae (gi15900526).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1222 (0.0).","

InterPro
IPR000305
Domain

Excinuclease ABC, C subunit, N-terminal
PF01541	$\"[15-96]T$	GIY-YIG
SM00465	$\"[15-95]T$	GIYc
PS50164	$\"[16-91]T$	UVRC_1

InterPro
IPR001162
Domain

Excinuclease ABC, C subunit, C-terminal
PD005870	$\"[365-537]T$	UvrC_C
PF08459	$\"[369-523]T$	UvrC_HhH_N
PS50165	$\"[247-466]T$	UVRC_2

InterPro
IPR001943
Domain

UvrB/UvrC protein
PF02151	$\"[196-231]T$	UVR
PS50151	$\"[196-231]T$	UVR

InterPro
IPR004791
Family

Excinuclease ABC, C subunit
TIGR00194	$\"[5-570]T$	uvrC

InterPro
IPR009055
Domain

UvrB, C-terminal UvrC-binding
SSF46600	$\"[181-236]T$	UvrB_C

InterPro
IPR010994
Domain

RuvA domain 2-like
SSF47781	$\"[498-592]T$	RuvA_2_like

noIPR
unintegrated

unintegrated
G3DSA:1.10.150.20	$\"[536-590]T$	G3DSA:1.10.150.20
SSF82771	$\"[14-97]T$	SSF82771

","BeTs to 13 clades of COG0322COG name: Nuclease subunit of the excinuclease complexFunctional Class: LThe phylogenetic pattern of COG0322 is --t--qvCEBRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000305 (UvrC homology region 1) with a combined E-value of 1.3e-14. IPB000305A 17-44 IPB000305B 78-90***** IPB001943 (UvrB/uvrC motif) with a combined E-value of 5.7e-08. IPB001943B 91-100 IPB001943C 202-229","Residues 234-550 are 63% similar to a (ABC SUBUNIT EXCINUCLEASE EXCISION) protein domain (PD005870) which is seen in UVRC_BACSU.Residues 14-91 are 87% similar to a (ABC SUBUNIT EXCINUCLEASE EXCISION) protein domain (PD013358) which is seen in UVRC_LACLA.Residues 93-193 are 57% similar to a (ABC SUBUNIT EXCINUCLEASE EXCISION) protein domain (PD005749) which is seen in UVRC_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 10 09:24:04 2006","Tue Feb 26 14:38:47 2002","Thu Aug 10 09:24:04 2006","Tue Feb 26 14:38:47 2002","Tue Feb 26 14:38:47 2002","Tue Feb 26 14:38:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1136 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 14:38:47 2002","","No significant hits to the NCBI PDB database.","SMU.1241c","","Residues 15 to 96 (E-value = 1.3e-33) place SMu1136 in the GIY-YIG family which is described as GIY-YIG catalytic domain (PF01541)Residues 196 to 231 (E-value = 7.9e-07) place SMu1136 in the UVR family which is described as UvrB/uvrC motif (PF02151)","Thu Aug 10 09:24:04 2006","","","","Chen,N.Y., Zhang,J.J. and Paulus,H.Chromosomal location of the Bacillus subtilis aspartokinase II gene and nucleotide sequence of the adjacent genes homologous to uvrC and trx of Escherichia coliJ. Gen. Microbiol. 135 (Pt 11), 2931-2940 (1989)PubMed: 2559145","","Tue Feb 26 15:03:42 2002","1","","","SMU.1241c","137" "SMu1137","1181478","1182548","1071","ATGTCTCAGTTTTTATCAAAACGTGTCTCCAACTATGAACTCTTTTTCGATCTTACTGTTGTTTTGGCTATTGGTCAGCTGACTTCTGCTATTCATCTCAACCACATTGGTCTTCAAGAAGTTTTAGCTTTTATTACGACTAATATTATTATCTTTAATATCTGGCATAATGAAGTGCTTTATTTTAATAAATACGGAGATTCTAGACTGCAGGATATTTACACGATTATTGCTCTCATGTTTATAGTGGGCAATATTTCGCTCAACTTCAGTCTCAATATTAAGGGCTACTATGCTGGAAATCCTCAGCTGATGCTCTTTAATTTCCTGCTGATGCTAGCCTATGCTTTTATTGCTCTGCAATATTTTTTAAAAGGGAAAAAATTAGGTTTTAGTCATAATATTAAGCTCAGCATACTATCGCAGCTGAGTTACAGTCTGCCTTTGGCGGGTTTAGCACTAGGTTTGCTACCTCTCAATATCTGGACGGCTCTTATTTATCTCCTGCCCAATCTTCTTCCTATCTTCAGCAGAAAATTTTACAATCATCAGCTGCTCAACTTCCCGCATATCGTTGAACGTCTGCATTTGGTAACTCTTTTAACCTTTGGAGAATCCGTTATTGCTATTATCAAAACCTATCCTTTAAAAGATCAGCCTTTAACTGGGTTCATGCTCTTTTTTGGAATGGCAACACTTTTTGTTTTTTATATGGGACAAACTTTTTTAAATATCAATCATCACCAAGAAACAACTGCTAGTATTCTCTTTTATGCTCACCTACCAATCTTTGCTGGTATTAATATTTTCACTGTAGGTATCGAATTTCTGGCTGAATCCCACCATGCTAATATTGGTTTTATACTGTTTCTTGCTGGTATTATTAGCTTTTATCTGGGTGTTCTAGCGACTTCCCGCTATAACAAAGACCTTTATCGCTTTGACCTAAAAGCTTGGCTGCACTATCTTAACAGGTTTTATACTAATGATTTTACTGAAATCCCATCTCATTTTCTTAGCTTTGATTTTAGTCCTGCAAAATCGGCTTATGATGCGCATCAATATGGCTAA","9.40","5.60","40861","MSQFLSKRVSNYELFFDLTVVLAIGQLTSAIHLNHIGLQEVLAFITTNIIIFNIWHNEVLYFNKYGDSRLQDIYTIIALMFIVGNISLNFSLNIKGYYAGNPQLMLFNFLLMLAYAFIALQYFLKGKKLGFSHNIKLSILSQLSYSLPLAGLALGLLPLNIWTALIYLLPNLLPIFSRKFYNHQLLNFPHIVERLHLVTLLTFGESVIAIIKTYPLKDQPLTGFMLFFGMATLFVFYMGQTFLNINHHQETTASILFYAHLPIFAGINIFTVGIEFLAESHHANIGFILFLAGIISFYLGVLATSRYNKDLYRFDLKAWLHYLNRFYTNDFTEIPSHFLSFDFSPAKSAYDAHQYG","1182557","","conserved hypothetical protein (possible low temperature requirement protein A)","Membrane, Cytoplasm, Extracellular","Matches weakly in gapped BLAST to low temperature requirement protein A:residues 7-341 are 25% similar to the protein from Listeria innocua (gi|16799484|) and are 22% similar to the protein from Listeria monocytogenes EGD-e (gi|16802434|).SMu1137 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010640
Family

Bacterial low temperature requirement A
PF06772	$\"[6-346]T$	LtrA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 55-267 are 24% similar to a (A PROTEOME 5'REGION COMPLETE) protein domain (PD191439) which is seen in Q9ZIM4_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 15:09:36 2002","Thu Oct 17 14:57:51 2002","Thu Oct 17 14:57:51 2002","Tue Feb 26 15:08:34 2002","","Thu Oct 17 14:57:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1137 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 15:08:34 2002","","No significant hits to the NCBI PDB database.","SMU.1243","","Residues 6 to 346 (E-value = 1.7e-158) place SMu1137 in the LtrA family which is described as Bacterial low temperature requirement A protein (LtrA) (PF06772)","Tue Feb 26 15:08:34 2002","24379666","","","","","","1","","","SMU.1243","" "SMu1138","1183222","1182665","558","ATGAATCAGCAACTTTGGCAGGATTTGACCTTGAATAAAATCAGCAAAAAAGAATTGGTCAACACACGTTTTGCTAAGCTTTTTGCCCATTTTGGTCAGAAAGTGGATGGTCGTACCCTTGCGAATCGTTATCAGAATTTTCTAAGCCAGCAAGGGCAGACTTTGACTGGTGCTGAGACTTTGTTAGAAAAACTAACTGATGAGGGTTATCGTATTTTTGGAGCAACCAATGGTATCGCCAATATTCAGACAGGGCGTATGGCTAATTCCAACATTGCATCTTATTTTGAACAAGTCTTTATCTCAGATAGGATTGGTTTTCAAAAACCTGACAAGGCTTTTTACGATTATATTGCTGATGATATTGCTTATTTTGATTATAGCAGAGCACTGATGATTGGCGATAGTCTCTTAGCTGATATTCAAGGCGGCAATAATGCAGGAATTGATACTGTTTGGTACAACCCTTATATCAAAACCAATGAGACCGGTATAAGACCGACTTATGAAGTCAATGATTACAAGCAACTCCTTGCCTTATTAGTACGAAAAAGCTGA","7.50","0.23","21034","MNQQLWQDLTLNKISKKELVNTRFAKLFAHFGQKVDGRTLANRYQNFLSQQGQTLTGAETLLEKLTDEGYRIFGATNGIANIQTGRMANSNIASYFEQVFISDRIGFQKPDKAFYDYIADDIAYFDYSRALMIGDSLLADIQGGNNAGIDTVWYNPYIKTNETGIRPTYEVNDYKQLLALLVRKS","1182680","","hydrolase, haloacid dehalogenase-like family ","Cytoplasm, Extracellular","Matches in gapped BLAST to hydrolase and to conserved hypothetical protein: residues 1-181 are 57% similar to hydrolase in S.pneumoniae (gi15901036).Residues 1-178 are 53% similar to conserved hypothetical protein from S.pyogenes (gi15675058).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0751 (7e-08).","

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[57-157]T$	Hydrolase

InterPro
IPR006439
Family

HAD-superfamily hydrolase, subfamily IA, variant 1
TIGR01549	$\"[6-148]T$	HAD-SF-IA-v1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[54-181]T$	G3DSA:3.40.50.1000
PTHR12725	$\"[20-184]T$	PTHR12725
PTHR12725:SF4	$\"[20-184]T$	PTHR12725:SF4
SSF56784	$\"[1-181]T$	SSF56784

","BeTs to 5 clades of COG1011COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG1011 is -mtKY-V-EB---j--o----Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 58-173 are 30% similar to a (PROTEOME COMPLETE HYDROLASE PHOSPHATASE DEHALOGENASE) protein domain (PD000816) which is seen in Q9CFG1_LACLA.Residues 1-58 are 37% similar to a (PROTEOME COMPLETE YFNB) protein domain (PD414548) which is seen in O06480_BACSU.Residues 130-181 are 44% similar to a (COMPLETE PROTEOME) protein domain (PD202150) which is seen in P94512_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 15:18:58 2002","Thu Mar 1 11:06:22 2007","Thu Mar 1 11:06:22 2007","Tue Feb 26 15:15:34 2002","","Tue Feb 26 15:15:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1138 is paralogously related (blast p-value < 1e-3) to SMu0702, and SMu1168, both predicted conserved hypothetical proteins ; possible hydrolase.","Thu Mar 21 14:17:46 2002","","No significant hits to the NCBI PDB database.","SMU.1245c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 15:15:34 2002","24379667","","","","","","1","","","SMU.1245c","" "SMu1139","1183870","1183574","297","ATGGATAAATCAAAAAAGAAAACGGACTCTCGAGTGATTAAAACTCGCTGCTGTATTGAAGAAACTTTCTTGAAGCTGTTAACCGAGGTTCCTTTTGAGAAATTAACGACGACTCGTTTGATTAAGGAGTGCATAATTAGTAAAGGGACCTTTTATGCCCATTATTTAGATAAATATGATTTAGCGGAGCAACTGATTGACCGAGAACTAAAGTTTTTTGAAAATCTCCTCCTTCAGCGCTTTCAAAGTTTTTATGTCTTATTAATCAGTGACACAGATTGCGTTTTTAATGATTAG","7.00","0.00","11684","MDKSKKKTDSRVIKTRCCIEETFLKLLTEVPFEKLTTTRLIKECIISKGTFYAHYLDKYDLAEQLIDRELKFFENLLLQRFQSFYVLLISDTDCVFND","1183589","","transcriptional regulator (TetR/AcrR family)","Cytoplasm","Matches in gapped BLAST to transcriptional regulator:residues 15-65 are 37% similar to the previously published enzyme PsaR in S.mutans (gi|15625443|). Residues 5-81 are 44% similar to transcriptional regulator in Clostridium acetobutylicm (gi|15893494|) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2135 (1e-08).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[24-65]T$	TetR_N

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[4-83]T$	Homeodomain_like

","BeTs to 4 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","No significant hits to the Blocks database.","Residues 6-77 are 41% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD106875) which is seen in Q9CDI1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 15:26:06 2002","Tue Feb 26 15:23:09 2002","Thu Oct 17 14:58:50 2002","Tue Feb 26 15:23:09 2002","","Tue Feb 26 15:23:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1139 is paralogously related (blast p-value < 1e-3) to SMu1171, SMu0398, SMu1069, SMu1936, SMu1750, SMu0466, SMu1440, and SMu0120, all predicted transcriptional regulators.","Tue Feb 26 15:23:09 2002","","No significant hits to the NCBI PDB database.","SMU.1246c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 15:23:09 2002","24379668","","","","","","1","","","SMU.1246c","" "SMu1140","1185232","1183934","1299","ATGTCAATTATTACTGATGTTTACGCTCGCGAAGTCCTTGACTCACGCGGTAACCCAACACTTGAAGTAGAAGTTTACACTGAATCAGGTGCATTCGGACGTGGTATGGTTCCTTCAGGAGCTTCTACTGGTGAACACGAAGCAGTTGAACTTCGCGATGGAGATAAATCACGTTATGGTGGTCTTGGTACTCAAAAAGCTGTTGATAATGTAAACAATATTATTGCTGAAGCACTTATCGGATATGATGTTCGTGATCAACAAGCTATTGATAAAGCAATGATCGCACTTGACGGTACTCCAAACAAAGGTAAACTTGGTGCTAATGCTATTCTTGGTGTTTCTATTGCTGTAGCTCGTGCTGCTGCTGATTTCCTTGAAATTCCACTTTACAGCTACCTTGGTGGATTTAACACTAAAGTTCTGCCAACTCCAATGATGAACATCATCAACGGTGGTTCTCACTCAGATGCTCCAATCGCTTTCCAAGAATTTATGATTGTACCTGCTGGTGCACCTACATTCAAAGAAGCTCTTCGTTGGGGTGCTGAAATCTTCCATGCACTTAAGAAAATTCTTAAGGAACGCGGACTTGAAACAGCTGTTGGTGACGAAGGTGGATTCGCTCCTAAGTTTGATGGAACTGAAGACGCTGTAGAAACAATTATCAAAGCTATTGAAACAGCTGGTTACAAACCAGGTGAAGAAGTCTTCCTTGGATTTGACTGTGCGTCATCAGAATTCTATGATAATGGTGTTTATGACTACACTAAATTCGAAGGTGAAAAAGGTGCTAAGCGTTCAGCTGCAGAACAAATTGATTATATTGAAGAATTGGTTAACAAATACCCAATTATCACAATTGAAGATGCTATGGACGAAAATGACTGGGATGGCTGGAAAGCATTGACTGCTCGCCTTGGTGACCGTGTACAATTGGTTGGTGACGACTTCTTCGTTACAAATACGGACTACCTTGCTCGTGGTATCAAAGAAGGTGCTGCAAACTCAATCCTTATCAAAGTTAACCAAATCGGTACTTTGACTGAAACATTTGAAGCTATCGAAATGGCTAAAGAAGCTGGTTATACTGCCGTTGTATCACACCGTTCAGGTGAAACTGAAGATTCAACAATCGCTGATATTTCAGTTGCAACCAACGCTGGACAAATCAAGACTGGTTCATTGTCACGTACAGATCGTATTGCTAAATACAACCAATTGCTTCGTATCGAAGATCAACTTGGTGAAGTCGCTGAATACCGTGGTCTTAAATCATTCTACAACTTGAAAAAATAA","4.50","-23.03","46846","MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEALIGYDVRDQQAIDKAMIALDGTPNKGKLGANAILGVSIAVARAAADFLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIVPAGAPTFKEALRWGAEIFHALKKILKERGLETAVGDEGGFAPKFDGTEDAVETIIKAIETAGYKPGEEVFLGFDCASSEFYDNGVYDYTKFEGEKGAKRSAAEQIDYIEELVNKYPIITIEDAMDENDWDGWKALTARLGDRVQLVGDDFFVTNTDYLARGIKEGAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADISVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK","1183949","","enolase","Cytoplasm","Several matches in gapped BLAST to enolase: residues 1-432 are 92% similar to the enzyme in S.pneumoniae (gi15903080) and are 90% similar to the enzyme in S.pyogenes (gi15674785). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0628 (0.0).","

InterPro
IPR000941
Family

Enolase
PD000902	$\"[145-430]T$	Enolase
PR00148	$\"[37-51]T$ $\"[107-123]T$ $\"[161-174]T$ $\"[315-326]T$ $\"[338-352]T$ $\"[367-384]T$	ENOLASE
PTHR11902	$\"[1-210]T$	Enolase
PF00113	$\"[139-430]T$	Enolase_C
PF03952	$\"[3-134]T$	Enolase_N
TIGR01060	$\"[4-430]T$	eno
PS00164	$\"[338-351]T$	ENOLASE

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.120	$\"[128-432]T$	G3DSA:3.20.20.120
G3DSA:3.30.390.10	$\"[3-127]T$	G3DSA:3.30.390.10
PIRSF001400	$\"[2-432]T$	Enolase
SSF51604	$\"[137-430]T$	SSF51604
SSF54826	$\"[2-140]T$	SSF54826

","BeTs to 16 clades of COG0148COG name: EnolaseFunctional Class: GThe phylogenetic pattern of COG0148 is aMtKYqvcebrhujgpolin-Number of proteins in this genome belonging to this COG is 1","***** IPB000941 (Enolase) with a combined E-value of 1.2e-172. IPB000941A 9-22 IPB000941B 34-55 IPB000941C 90-135 IPB000941D 142-178 IPB000941E 200-231 IPB000941F 283-300 IPB000941G 311-346 IPB000941H 379-416","Residues 65-286 are 27% similar to a (MJ0198) protein domain (PD040858) which is seen in Y198_METJA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 15:30:23 2002","Tue Feb 26 15:30:00 2002","Thu Feb 3 14:58:41 2005","Tue Feb 26 15:30:00 2002","Tue Feb 26 15:30:00 2002","Tue Feb 26 15:30:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1140 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 15:30:23 2002","Thu Feb 3 14:58:41 2005","pdb1ONEA Chain A, Yeast Enolase Complexed With An Equilibrium... 402 5e-113pdb4ENL Enolase (E.C.4.2.1.11) (2-Phospho-D-Glycerate Hydr... 400 1e-112pdb1PDZ Mol_id: 1; Molecule: Enolase; Chain: Null; Synonym... 391 8e-110","SMU.1247c","","Residues 3 to 134 (E-value = 8.7e-69) place SMu1140 in the Enolase_N family which is described as Enolase, N-terminal domain (PF03952)Residues 139 to 430 (E-value = 8.8e-165) place SMu1140 in the Enolase_C family which is described as Enolase, C-terminal TIM barrel domain (PF00113)","Thu Feb 3 14:58:41 2005","","","Ge J, Catt DM, Gregory RL.Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen.Infect Immun. 2004 Nov;72(11):6748-52.PMID: 15501816","Leyva-Vazquez,M.A. and Setlow,P.Cloning and nucleotide sequences of the genes encoding triosephosphate isomerase, phosphoglycerate mutase, and enolase fromBacillus subtilisJ. Bacteriol. 176 (13), 3903-3910 (1994)PubMed: 8021172Bergmann S, Rohde M, Preissner KT, Hammerschmidt S.The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigration.Thromb Haemost. 2005 Aug;94(2):304-11.PMID: 16113819","Thu Jul 27 11:00:43 2006","Thu Apr 26 09:21:02 2007","1","","","SMU.1247c","70" "SMu1141","1186270","1185629","642","ATGGAAAATAAAACCAATGTTTGGAAAGTCCTTGGCATTATTTTTATAGTGACAGCCAGTATCTTTTTCATTGCTACGATTGTTATGACGGCTTTGTATGCGACATCAAGACAGGATTTTAATAAGTGGACAGCGACAAATAGCATGCAAGATCGGACCATTACTAATAAGAAAAAGGCCATAAAAAATCTTAAAATTCGAGAAAAAATTAGAGATAATTATTATGGTGATGACTATGAGTCTACTGACAAGGTGACCAAATATATTTTTGGAGAGAGTGCTAAAATGAGTACAGGAGAAGAAGTCACGGTAACAGGAGTCAAAGAAGATTCTAAAGTCAAGATGAAAGGTGTTTCTAAAAAGGATAAGAAAATCGTCCTTACTGTTAGTGTTAAGAATACGACTGATAAAATGATCCAATTTAGTCCGGATGATTTCTTTATCTATGATAGAAACTATGATATTGCTGAGCCAAGTAATTATACAGGTAAGCAAAAAATTCCTGATATTATTGAAGCAGGAAAGACAATTGAGGTTAAGCTTTATTATACTATTCCCAAGTCTTCTCCTTATATAGTAAACTTTGAAAATGCTTACTGGATACCACAAACACAGACGCAAAAGAAATCAAGGACTGTCTAA","10.30","10.00","24519","MENKTNVWKVLGIIFIVTASIFFIATIVMTALYATSRQDFNKWTATNSMQDRTITNKKKAIKNLKIREKIRDNYYGDDYESTDKVTKYIFGESAKMSTGEEVTVTGVKEDSKVKMKGVSKKDKKIVLTVSVKNTTDKMIQFSPDDFFIYDRNYDIAEPSNYTGKQKIPDIIEAGKTIEVKLYYTIPKSSPYIVNFENAYWIPQTQTQKKSRTV","1185644","","hypothetical protein","Membrane, Extracellular","No significant hits in gapped BLAST found.SMu1141 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-26]?$	signal-peptide
tmhmm	$\"[14-34]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-27]?$	signal-peptide
tmhmm	$\"[10-30]?$	transmembrane_regions

InterPro
IPR012543
Family

Protein of unknown function DUF1694
PF07997	$\"[1-122]T$	DUF1694

InterPro
IPR004381
Family

Glycerate kinase
PF02595	$\"[1-369]T$	Gly_kinase
TIGR00045	$\"[2-369]T$	Glyc_kinase

noIPR
unintegrated

unintegrated
G3DSA:3.90.1510.10	$\"[42-270]T$	G3DSA:3.90.1510.10
PTHR21599	$\"[2-370]T$	PTHR21599
SSF110738	$\"[1-368]T$	SSF110738

","BeTs to 4 clades of COG1929COG name: Uncharacterized BCRFunctional Class: SThe phylogenetic pattern of COG1929 is -------cEbrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB003747 (Glycerate kinase/DUF168) with a combined E-value of 6.6e-77. IPB003747A 1-26 IPB003747B 40-49 IPB003747C 104-148 IPB003747D 186-228 IPB003747E 278-318","Residues 1-362 are 41% similar to a (KINASE TRANSFERASE GLYCERATE COMPLETE) protein domain (PD011710) which is seen in GRK_NEIMB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 15:46:50 2002","Thu Oct 17 15:07:10 2002","Fri Jul 7 16:58:30 2006","Tue Feb 26 15:46:19 2002","Tue Feb 26 15:46:19 2002","Tue Feb 26 15:46:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1144 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 15:46:19 2002","","No significant hits to the NCBI PDB database.","SMU.1252c","","Residues 1 to 369 (E-value = 8.5e-80) place SMu1144 in the Gly_kinase family which is described as Glycerate kinase family (PF02595)","Tue Feb 26 15:46:19 2002","","","","","","","1","","","SMU.1252c","785" "SMu1145","1188803","1188378","426","ATGATCGTTCATTTTTCAGAAACAAGTGAAGAGTTAACATCTTTTTTTAATCAGATTTTTGAAGAACAATATGTTCAGTACTTTCAAGAAGCAAAACCTAAAAATCAGAAAAAACAAGTACAGTTTGTGGTCAAAGATGATGCTGCGCGCATTTTGGCAGCAGCTTCTTGTCAGCAACTTTACCAAACGCTGAAGATTGAAAATTTGGCAGTGGACAGTGTCTTTCAAAAGCAAAAATTTGGCAGTCAGTTATTGGATTATATCAAAGACTATGCGCGTGCTCATAACATTTTGACTCTGACCTTAAGCACGCGCTCCTATCAGGCCAAGGATTTTTATCTCAAGCAGGGTTTTCATATCTATGGCCAGTTAGCAGATGTGCCTTTTGAGGGTGTGACGACTTATTATTTTGTCTATAAGTTATAA","7.50","0.66","16524","MIVHFSETSEELTSFFNQIFEEQYVQYFQEAKPKNQKKQVQFVVKDDAARILAAASCQQLYQTLKIENLAVDSVFQKQKFGSQLLDYIKDYARAHNILTLTLSTRSYQAKDFYLKQGFHIYGQLADVPFEGVTTYYFVYKL","1188393","","hypothetical protein","Cytoplasm","Weakly matches in gapped BLAST to blasticidin S-acetyltransferase: residues 50-138 are 33% similar to gi|16799490| from Listeria innocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0909 (4e-06).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[43-119]T$	Acetyltransf_1
PS51186	$\"[1-141]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[39-140]T$	G3DSA:3.40.630.30
SSF55729	$\"[1-141]T$	SSF55729

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[2-187]T$	Hydrolase

InterPro
IPR006439
Family

HAD-superfamily hydrolase, subfamily IA, variant 1
TIGR01549	$\"[4-178]T$	HAD-SF-IA-v1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[2-213]T$	G3DSA:3.40.50.1000
PTHR18901	$\"[2-214]T$	PTHR18901
SSF56784	$\"[1-213]T$	SSF56784

","BeTs to 8 clades of COG0546COG name: Predicted phosphatasesFunctional Class: RThe phylogenetic pattern of COG0546 is a-TkyQ-CEBRhuj--oL---Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 92-192 are 46% similar to a (PROTEOME COMPLETE HYDROLASE PHOSPHATASE) protein domain (PD000816) which is seen in YM33_MYCTU.Residues 2-90 are 50% similar to a (PROTEOME PA0065 COMPLETE) protein domain (PD393329) which is seen in Q9I767_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:07:38 2002","Thu Mar 1 11:08:36 2007","Thu Mar 1 11:08:36 2007","Tue Feb 26 16:00:23 2002","","Tue Feb 26 16:00:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1146 is paralogously related (blast p-value < 1e-3) to SMu1593, a predicted conserved hypothetical protein, possible phosphatase .","Tue Feb 26 16:00:23 2002","","No significant hits to the NCBI PDB database.","SMU.1254","","Residues 2 to 187 (E-value = 8.4e-24) place SMu1146 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Tue Feb 26 16:00:23 2002","24379675","","","","","","1","","","SMU.1254","" "SMu1147","1189788","1189531","258","GTGACGGTTTCTTTTGAAGGTGTTTCCTATGTCAGCACTTCTTTTGTCAATTCAGCTTTTATTCATTTACTAGAGAACTTTATCTTTAACACCATTAAAGCAAAACTCTCTTTCATTAAATCAACTATTCAAATTAATAAGTTGATAAAAGAACGCTTCGTCTTTGAATCATTGCCATCCTGCCTTCGGAACTTCCCTATATCTCTTTATTGCAAAAACTCTGAGCAGATAGGAGCTGCTCAGAGTTTTTTGTTATAA","9.40","3.13","9612","MTVSFEGVSYVSTSFVNSAFIHLLENFIFNTIKAKLSFIKSTIQINKLIKERFVFESLPSCLRNFPISLYCKNSEQIGAAQSFLL","1189546","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu1147 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 16:01:57 2002","Tue Feb 26 16:01:57 2002","Tue Feb 26 16:01:57 2002","Tue Feb 26 16:01:57 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1147 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 16:01:57 2002","","No significant hits to the NCBI PDB database.","SMU.1255c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 16:01:57 2002","24379676","","","","","","1","","","SMU.1255c","" "SMu1148","1190163","1189999","165","ATGAGTGAAAAAGAAACAGTTGACCAAATTGTTGCTAAGTATAACTACAGCATATCAGACTTATCTGATAATGCCACTGCTAAAGAATTTAAGACTGTCCTGACCTATATTGCTAAGGAAGCCAATAAGACTCAGAGGAAATTAGTTGGTCTGGATGCAGAATAG","5.00","-1.02","6052","MSEKETVDQIVAKYNYSISDLSDNATAKEFKTVLTYIAKEANKTQRKLVGLDAE","1190014","","hypothetical protein","Extracellular","No significant hits in gapped BLAST found.SMu1148 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 16:03:03 2002","Tue Feb 26 16:03:03 2002","Tue Feb 26 16:03:03 2002","Tue Feb 26 16:03:03 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1148 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 16:03:03 2002","","No significant hits to the NCBI PDB database.","SMU.1256c","","No significant hits to the Pfam 11.0 database","Tue Feb 26 16:03:03 2002","24379677","","","","","","1","","","SMU.1256c","" "SMu1149","1190827","1190156","672","GTGTCTGCTGATAAGTATTTAGATTATTCTAAGGAGCACTTGGACAGCATTCTATCGGATTTGTTTGGAAATAAGCAACCGAGTTCTAAGAAGGATGCTATCTTTATGGCAGGAAGTCCTGGGGCTGGTAAGTCGGAGGTTGCACATTTGCTAGCTGATAGTTACAAGAATATGATTGTGTTGGATACAGACGATTTTCGTTGTCTCTTTCCAGACTATGATGGTAGTAATTCCAGCAACTTTCAAAAGGCCTGTTCTTGGCTAACTGAACAAGCTTTTCAGTATCTGACAGAGAAAGGCTACTCATTTATTTACGATACAACTTTTGCTGTGCCGAGTACAGAAAAGAAGATAAAACGTGTCTTGAAGAATGGTTACAGGCCTGTGATTTTCTACGTATATCAAGAACCGAAAATTGCTTGGCAGTTTACCAAAGATAGGGAAAGAGTAGAAGGAAGAAAAGTCCCTAAAGAAACCTTTATCAATGCGTTTTTACATGCAAGAGAAAATGTTGAAAAAGTTAAAGTTCGTCACCCAGAGACCTTAGTACATCTTATCATTAAGGATTATCAGAATACCATTGAAGAAGTCCATTTTGATATGGAAAACATCAATCTGATATTACCAAATAACAACACAAGAGAAACTTTAGAGGAGGAACTTTATGAGTGA","5.70","-4.64","25926","MSADKYLDYSKEHLDSILSDLFGNKQPSSKKDAIFMAGSPGAGKSEVAHLLADSYKNMIVLDTDDFRCLFPDYDGSNSSNFQKACSWLTEQAFQYLTEKGYSFIYDTTFAVPSTEKKIKRVLKNGYRPVIFYVYQEPKIAWQFTKDRERVEGRKVPKETFINAFLHARENVEKVKVRHPETLVHLIIKDYQNTIEEVHFDMENINLILPNNNTRETLEEELYE","1190171","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein only from S.pneumoniae: residues 6-203 are 25% similar to gi|15902996|.SMu1149 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010488
Family

Zeta toxin
PF06414	$\"[6-196]T$	Zeta_toxin

InterPro
IPR013716
Domain

Adenylate cyclase G-alpha binding
SM00789	$\"[3-43]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-174]T$	no description

InterPro
IPR011639
Domain

Restriction endonuclease, Eco57I
PF07669	$\"[5-100]T$	Eco57I

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-97 are 60% similar to a (ENDONUCLEASE RESTRICTION PLASMID) protein domain (PD139246) which is seen in O53070_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:09:03 2002","Wed Feb 27 08:24:46 2002","Thu Oct 17 15:09:03 2002","Wed Feb 27 08:24:46 2002","","Wed Feb 27 08:24:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1151 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 15:09:03 2002","","No significant hits to the NCBI PDB database.","SMU.1259","","No significant hits to the Pfam 11.0 database","Wed Feb 27 08:24:46 2002","24379680","","","","","","1","","","SMU.1259","" "SMu1152","1192534","1192355","180","ATGATAACAGCAGAAGACATTGTAGAAAAACAGTTTTCTGCCACGTTTCGAGGTTATAATCAGGAAGAAGTTGATGAGTTTCTTGATGACATTACAGAAACTTTGAAGACCCTAGAAAAAGAAAAACAATCTCTTAAGCGACAAGTAAAAAGACTGAAAGAAGACCAGCGGGATTTATAA","4.60","-4.01","7060","MITAEDIVEKQFSATFRGYNQEEVDEFLDDITETLKTLEKEKQSLKRQVKRLKEDQRDL","1192370","","conserved hypothetical protein","Cytoplasm","Matches weakly in gapped BLAST to conserved hypothetical proteins: residues 1-55 are 41% similar to S.pneumoniae (gi|15902376|) and residues 2-54 are 39% similar to B.subtilis (gi|16079276|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0484 (3e-07).","

InterPro
IPR007793
Family

DivIVA
PF05103	$\"[1-54]T$	DivIVA

InterPro
IPR008179
Domain

Phosphoribosyl-ATP pyrophosphohydrolase
PD002611	$\"[2-45]T$	Q8DTR6_STRMU_Q8DTR6;
PF01503	$\"[1-47]T$	PRA-PH

noIPR
unintegrated

unintegrated
PTHR21256	$\"[1-45]T$	HISTIDINOL DEHYDROGENASE (HDH)

","BeTs to 7 clades of COG0140COG name: Phosphoribosyl-ATP pyrophosphohydrolaseFunctional Class: EThe phylogenetic pattern of COG0140 is -mt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-47 are 59% similar to a (BIOSYNTHESIS HISTIDINE PHOSPHORIBOSYL-ATP) protein domain (PD002611) which is seen in Q9RWD6_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:15:58 2002","Wed Feb 27 08:34:41 2002","Thu Oct 17 15:15:58 2002","Wed Feb 27 08:34:41 2002","","Wed Feb 27 08:34:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1153 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 08:35:28 2002","","No significant hits to the NCBI PDB database.","SMU.1261c","","Residues 1 to 47 (E-value = 9.4e-05) place SMu1153 in the PRA-PH family which is described as Phosphoribosyl-ATP pyrophosphohydrolase (PF01503)","Wed Feb 27 08:34:41 2002","24379682","","","Oriol,E., Mendez-Alvarez,S., Barbe,J. and Gibert,I.Cloning of the Rhodobacter sphaeroides hisL gene: unifunctionalityof the encoded protein and lack of linkage to other his genesMicrobiology 142 (Pt 8), 2071-2078 (1996)PubMed: 8760919","","Wed Feb 27 08:37:13 2002","1","","11","SMU.1261c","" "SMu1154","1194152","1192812","1341","ATGAGATTTGCTAGGATTATAAAATCTGTTTGGAATTGTATGCAACGTTTAATAGTACTTTTACCAATGTTGACTGTAATTTCTTTACTTATTTTAGGAAGTTTATTATTCTTAGTTTCTTTGATTCCATCATTACTTCTTAAAGGTAGAGATATAGTTGAATTTTTTATAATAATTATATTGCTAGTATATTTTGTGCATCTACTAAGAAATCAATTATTGATTAGATATGGAATATTATATACAATTTTAACCATATCAAGTGTTTCAATATTTTGCTTACCTCAATATAGGTCAATCATATTATTGCAGCCGACTATTTTATTTATTTATGCTATATATCAAGAATCAAGATTGATTCAGATTAAGAACTTTTTTGAAAAAAATAAAAGTGTATTAACATGGTTTAATATATTTGATGCAATTTATCTTTTGGCTTTTCTTTATAGAAAAAATTTAGATAAAACTTACGTAATAAATAAGATTTGGAGCATTTTTAATGATTTACATTTACCATTACTATTGACATCTATTGGACTCTTGGTAATCGTTCCAATGCTCATTCGTACAGTAATTGCAATTACTATATATAAGAAACAATATCATATTGAAGTTCCACCTAATAAAACTTTAGGAATGGTTTGGTTATCAAATTGTATTTGCTCTTTTTCTCAACTATTTATCATAATAGCACTTGTTGAACAAATAAAAACTGTTCAATTTGAAAGTATTGCTTTAACATTTTGCTTTATCTCATTTTTGAGTGTTCTTTTTTGGAATGTATCCTATGAGTCATTGAAAGATAATGGTGATGATAAAACTGAATTAATGTTAAGATTAACTGCAATATCTTTTGTTTTTATCATAATTGCTTTACTAAGTCAAAAAGAGAATGAAACAATTAGTATTTTAATGTGGTTGCTACCTATTGTAATTCCAATGTTTATTGGTGGGTTAGGTAAATTAGAACCACAATTTGTCTCAACTCAAAAACTAGATCGTCATGTGTATCAGTTGACGATGTTTAGTTTTAATACGTTACTGATTTATAGACTTCAATCTGTCTGTTCCGTTGAAATTAATGAGAATCAATATACATTAAAATCGTTAATAGTTTATGTATTAAAAGATAAATTTGAACAAGATAATTCTGGTTTCGTTGCAACATTAATTTTATTATTGCTATCATTAGGGGCAGGATATGAATTAAGTAAATTTTTAATATTATTATTGAAAAGAGTATATTTAAACTCAGACAATGGCTATTTTATAAAAAAAGGAGAAAAAAACAATGCTAGAAACACTTTACAAAGAAGCGCTAGATCGCAAAGAAAACCCTAA","10.30","17.68","51732","MRFARIIKSVWNCMQRLIVLLPMLTVISLLILGSLLFLVSLIPSLLLKGRDIVEFFIIIILLVYFVHLLRNQLLIRYGILYTILTISSVSIFCLPQYRSIILLQPTILFIYAIYQESRLIQIKNFFEKNKSVLTWFNIFDAIYLLAFLYRKNLDKTYVINKIWSIFNDLHLPLLLTSIGLLVIVPMLIRTVIAITIYKKQYHIEVPPNKTLGMVWLSNCICSFSQLFIIIALVEQIKTVQFESIALTFCFISFLSVLFWNVSYESLKDNGDDKTELMLRLTAISFVFIIIALLSQKENETISILMWLLPIVIPMFIGGLGKLEPQFVSTQKLDRHVYQLTMFSFNTLLIYRLQSVCSVEINENQYTLKSLIVYVLKDKFEQDNSGFVATLILLLLSLGAGYELSKFLILLLKRVYLNSDNGYFIKKGEKNNARNTLQRSARSQRKP","1192827","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu1154 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-36]?$	signal-peptide
tmhmm	$\"[21-43]?$ $\"[49-69]?$ $\"[74-94]?$ $\"[131-149]?$ $\"[170-192]?$ $\"[211-233]?$ $\"[243-263]?$ $\"[277-295]?$ $\"[300-320]?$ $\"[383-403]?$	transmembrane_regions

InterPro
IPR002496
Family

Phosphoribosyl-AMP cyclohydrolase
PD002610	$\"[52-105]T$	PRA_cyclohydro
PF01502	$\"[29-103]T$	PRA-CH

noIPR
unintegrated

unintegrated
PTHR21256	$\"[18-106]T$	PTHR21256

","BeTs to 10 clades of COG0139COG name: Phosphoribosyl-AMP cyclohydrolaseFunctional Class: EThe phylogenetic pattern of COG0139 is amt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 29-105 are 61% similar to a (BIOSYNTHESIS HISTIDINE PHOSPHORIBOSYL-AMP) protein domain (PD002610) which is seen in HIS2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:16:31 2002","Wed May 8 13:10:06 2002","Thu Oct 17 15:16:31 2002","Wed Feb 27 08:42:45 2002","","Wed Feb 27 08:42:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1155 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 08:42:45 2002","","No significant hits to the NCBI PDB database.","SMU.1263c","","Residues 29 to 103 (E-value = 2.9e-48) place SMu1155 in the PRA-CH family which is described as Phosphoribosyl-AMP cyclohydrolase (PF01502)","Wed Feb 27 08:42:45 2002","","","","Delorme,C., Ehrlich,S.D. and Renault,P.Histidine biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6571-6579 (1992)PubMed: 1400209","","Wed Feb 27 08:43:34 2002","1","","11","SMU.1263c","" "SMu1156","1195350","1194595","756","ATGTTAAAAAAACGGATTATTCCTTGCCTAGATGTCAAGGATGGACGCGTCGTTAAGGGTGTTAATTTTGTTAATCTGACTGATGTTGGTGATCCTGTTGATGCTGCGCGTGCTTATTATGAAGCGGGTTGTGATGAACTGGTCTTTTTAGATATTACAGCAACCTCGGACAATCGAGAAACGACAGTGGATATGGTAAGGCATGTAGCGGACCAAGTCTTTATTCCCTTTACTGTTGGCGGTGGTATTCGTTCAGTTGATGATATGAATAAAATGCTCAAGGCTGGTGCCGATAAGGTCGCTGTTAATTCATCGGCTATCGCCAATCCCCAGTTAATCAAGGATTGTGCTGAGAAATTTGGCAGCCAATGTGTGGTCGTTGCCATTGATGCGCGCAAAGAAGCAGATGATTCTTGGCATGTTTACGTTGCAGGTGGCCGAAAAGATACAGGCATTGATCTCTTGGCTTGGGTTAAAGAAGCCGTCCAGCTGGGTGCTGGCGAAATTCTCCTGACAAGCATGGATAAGGATGGCACCAAGTCTGGTTTTGACTTGGACATGTTGAATGCCGTTGCCCAGTTGGCTGATATTCCCATCATTGCCTCAGGTGGTGCCGGAAATATGGAGCATATGGTGGAAATTTTTGAAAAGACCCCAGCAACAGGTGCCTTAGCAGCATCCATTTTCCATTATGGCGAGGTTTCTATCGCAGATACTAAAAAAGCCATGAAAGAGCATGGAATCGAGGTGAGATAA","4.80","-9.98","26860","MLKKRIIPCLDVKDGRVVKGVNFVNLTDVGDPVDAARAYYEAGCDELVFLDITATSDNRETTVDMVRHVADQVFIPFTVGGGIRSVDDMNKMLKAGADKVAVNSSAIANPQLIKDCAEKFGSQCVVVAIDARKEADDSWHVYVAGGRKDTGIDLLAWVKEAVQLGAGEILLTSMDKDGTKSGFDLDMLNAVAQLADIPIIASGGAGNMEHMVEIFEKTPATGALAASIFHYGEVSIADTKKAMKEHGIEVR","1194610","For other 'his' genes see SMu1153 (hisE); SMu1155 (hisE),(hisI); SMu1157 (hisA);SMu1158 (hisH);SMu1160 (hisB); SMu1162 (hisD); SMu1163 (hisG); SMu1164 (hisZ) and SMu1165 (hisC). ","cyclase HisF/ imidazoleglycerol-phosphate synthase","Cytoplasm","Several matches in gapped BLAST to cyclase HisF/ Imidazoleglycerol -phosphate synthase: residues 1-251 are 63% similar to gi|16799647| from Listeria innocua and are 58% similar to gi|15894228| from Clostridium acetobutylicum. SMu1156 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004651
Domain

Histidine biosynthesis, HisF
TIGR00735	$\"[1-251]T$	hisF

InterPro
IPR006062
Domain

Histidine biosynthesis
PF00977	$\"[5-235]T$	His_biosynth

InterPro
IPR011060
Domain

Ribulose-phosphate binding barrel
SSF51366	$\"[1-251]T$	RibP_bind_barrel

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[4-251]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR21235	$\"[100-251]T$	PTHR21235
PTHR21235:SF2	$\"[100-251]T$	PTHR21235:SF2

","BeTs to 10 clades of COG0107COG name: Imidazoleglycerol-phosphate synthaseFunctional Class: EThe phylogenetic pattern of COG0107 is amt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000570 (Histidine biosynthesis protein) with a combined E-value of 3.5e-64. IPB000570A 5-19 IPB000570B 30-55 IPB000570C 75-85 IPB000570D 96-106 IPB000570E 165-206","Residues 4-241 are 58% similar to a (ISOMERASE HISTIDINE BIOSYNTHESIS CARBOXAMIDE) protein domain (PD000434) which is seen in HIS6_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:18:54 2002","Wed Apr 24 16:24:03 2002","Thu Oct 17 15:18:54 2002","Wed Feb 27 08:52:01 2002","Wed Feb 27 08:52:01 2002","Wed Feb 27 08:52:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1156 is paralogously related (blast p-value < 1e-3) to SMu1157, a predicted phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.","Wed Feb 27 09:06:19 2002","Thu Oct 17 15:18:54 2002","pdb|1THF|D Chain D, Cyclase Subunit Of Imidazoleglycerolphospha... 274 9e-075pdb|1QO2|A Chain A, Crystal Structure Of N-((5'-Phosphoribosyl)... 66 5e-012","SMU.1264c","","Residues 4 to 243 (E-value = 5.7e-127) place SMu1156 in the His_biosynth family which is described as Histidine biosynthesis protein (PF00977)","Wed Feb 27 08:52:01 2002","","","","","","","1","","11","SMU.1264c","" "SMu1157","1196072","1195353","720","ATGCAAATTCTTCCAGCTATCGATATTAAAAACGGTCATGCTGTCCGCCTTGTCAAGGGGGATTTTGAGCAAGAGACGGTTGTTAATGATAATGTTCTCGACCAAGCTAGTATTTTCATGGAAGCAGGTATCCAATACATCCATGTTGTCGATTTGGATGGTGCACTTGAAGGTCGGGCTGCTAATCGTGATTTAATTGCTAAGATTAAAGAAATGACAGGCTTGGCTATTGAAGTCGGCGGTGGTATTCGCACCATTGAACAAATTGAAGATTATTTATCTGTCGGTATTAATCGTGTGATTATTGGTTCTATGGCAGTTAAGCATCCCCAATTTGTCAAGGAAGCTCTGGATAAATTTGGCAGCGATAAAATTGTTGTTGGTATTGATGCTAAAAATGGGATGGTAGCTACAGAAGGTTGGCTGGAGACTAGCACCGTTGATTACATCAGCCTAGCTTTAGAGATGGAAAAGATGGGTGTCAGACTCCTTATCTATACCGATGTTGACCGTGATGGCACATTGACAGGCCCCAATTTTGAGCATTATGAGAAACTAATTGCTCACTTGACAAGTGCCAAGGTTATTGCCTCAGGTGGTATCCATGCCCTGTCAGATTTGCAACAATTAGAAAAGATTGGTGTTGCCGGAACCATTGTCGGCAAAGCTTATTATAATGGCGATATTAGTCTAAAAGAATTAAGAGAATTTGAGGGTTAG","4.70","-11.54","25998","MQILPAIDIKNGHAVRLVKGDFEQETVVNDNVLDQASIFMEAGIQYIHVVDLDGALEGRAANRDLIAKIKEMTGLAIEVGGGIRTIEQIEDYLSVGINRVIIGSMAVKHPQFVKEALDKFGSDKIVVGIDAKNGMVATEGWLETSTVDYISLALEMEKMGVRLLIYTDVDRDGTLTGPNFEHYEKLIAHLTSAKVIASGGIHALSDLQQLEKIGVAGTIVGKAYYNGDISLKELREFEG","1195368","For other 'his' genes see SMu1153 (hisE); SMu1155 (hisE),(hisI); SMu1156 (hisF);SMu1158 (hisH);SMu1160 (hisB); SMu1162 (hisD); SMu1163 (hisG); SMu1164 (hisZ) and SMu1165 (hisC). ","phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase","Cytoplasm","Several matches in gapped BLAST to phosphoribosylformimino - 5 - aminoimidazole carboxamide - ribotide isomeras: residues 1-238 are 51% similar to gi|16799648| from Listeria innocua and residues 1-235 are 48% similar to gi|477064| from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0033 (0.001).","

InterPro
IPR006062
Domain

Histidine biosynthesis
PF00977	$\"[2-230]T$	His_biosynth

InterPro
IPR006063
Family

Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
TIGR00007	$\"[3-234]T$	His4

InterPro
IPR011060
Domain

Ribulose-phosphate binding barrel
SSF51366	$\"[1-239]T$	RibP_bind_barrel

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-239]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR21235	$\"[100-239]T$	PTHR21235
PTHR21235:SF15	$\"[100-239]T$	PTHR21235:SF15

","BeTs to 9 clades of COG0106COG name: Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomeraseFunctional Class: EThe phylogenetic pattern of COG0106 is amt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000570 (Histidine biosynthesis protein) with a combined E-value of 4.4e-33. IPB000570A 2-16 IPB000570B 30-55 IPB000570C 75-85 IPB000570D 121-131 IPB000570E 160-201 IPB000570D 96-106","Residues 1-233 are 48% similar to a (ISOMERASE HISTIDINE BIOSYNTHESIS CARBOXAMIDE) protein domain (PD000434) which is seen in Q9RPQ5_THEET.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:19:15 2002","Wed Feb 27 09:12:02 2002","Thu Oct 17 15:19:15 2002","Wed Feb 27 09:12:02 2002","Wed Feb 27 09:12:02 2002","Wed Feb 27 09:12:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1157 is paralogously related (blast p-value < 1e-3) to SMu1156, a predicted cyclase HisF/ Imidazoleglycerol-phosphate synthase.","Wed Feb 27 09:38:06 2002","Thu Oct 17 15:19:15 2002","pdb|1QO2|A Chain A, Crystal Structure Of N-((5'-Phosphoribosyl)... 123 2e-029pdb|1THF|D Chain D, Cyclase Subunit Of Imidazoleglycerolphospha... 105 5e-024","SMU.1265c","","Residues 1 to 238 (E-value = 1.2e-78) place SMu1157 in the His_biosynth family which is described as Histidine biosynthesis protein (PF00977)","Wed Feb 27 09:12:02 2002","","","","Delorme,C., Ehrlich,S.D. and Renault,P.Histidine biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6571-6579 (1992)PubMed: 1400209Delorme,C., Godon,J.J., Ehrlich,S.D. and Renault,P.Gene inactivation in Lactococcus lactis: histidine biosynthesisJ. Bacteriol. 175 (14), 4391-4399 (1993)PubMed: 7687248","","Wed Feb 27 09:13:26 2002","1","","11","SMU.1265c","" "SMu1158","1197117","1196512","606","ATGATTATAGTTATTGATTACGACGCAGGCAATACCGCTAATGTCCTGCGGGCTTTGGATAAACTTGGTGTCAAGGCAGAACTATCAGCGGATCCGCAAAAGATTGTGGCAGCTTCAGGTTTGATTTTGCCAGGAGTTGGTGCCTTTCCAGCTGCCATGGCTGAACTTGAAAAAAGAGGCCTTGTGGCTGTTATCAAAGAAGCTGTTGCCAAAGGAATACCCCTTTTAGGCATTTGTCTGGGTATGCAATTATTAGTGGAAAAAGGTTTGGAACACTGTGAGACAGCTGGTTTTGGCTTTATTTCTGGTATTTGTCAAGAAATTTCAGCTAAAGCTGGTTTTCCTGTTCCCCATATGGGCTGGAATGATTTGCAGGTCAAGCAGAAGTCAGCTTTGACAGCCGGTTTGCAAGGTCAGGCTGTCTATTTCGTGCATAGCTACTTTACAGATGTCCCCCAAGAATACATTGATGTGACAGTTGACTATTCTATTGAAGTACCAGCCATGATTCACAAGGATAATGTCTACGGCGCTCAATTCCACCCTGAAAAATCGGGTGATGTCGGACTAGGTATTCTCAAAAAATTTGTGGATTTGTGTGACTGA","5.10","-5.99","21399","MIIVIDYDAGNTANVLRALDKLGVKAELSADPQKIVAASGLILPGVGAFPAAMAELEKRGLVAVIKEAVAKGIPLLGICLGMQLLVEKGLEHCETAGFGFISGICQEISAKAGFPVPHMGWNDLQVKQKSALTAGLQGQAVYFVHSYFTDVPQEYIDVTVDYSIEVPAMIHKDNVYGAQFHPEKSGDVGLGILKKFVDLCD","1196527","For other 'his' genes see SMu1153 (hisE); SMu1155 (hisE),(hisI); SMu1156 (hisF);SMu1157 (hisA);SMu1160 (hisB); SMu1162 (hisD); SMu1163 (hisG); SMu1164 (hisZ) and SMu1165 (hisC). ","amidotransferase; possible imidazoleglycerol-phosphate synthase","Cytoplasm","Several matches in gapped BLAST to amidotransferases / imidazoleglycerol-phosphate synthase:residues 1-201 are 52% similar to amidotransferase from Listeria innocua gi|16799649|and residues 2-198 are 47% similar to imidazoleglycerol-phosphate synthase from Lactococcus lactis (gi|478258|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0967 (1e-10).","

InterPro
IPR000991
Domain

Glutamine amidotransferase class-I
PF00117	$\"[3-199]T$	GATase

InterPro
IPR006220
Domain

Anthranilate synthase component II/delta crystallin
PR00097	$\"[74-85]T$ $\"[177-190]T$	ANTSNTHASEII

InterPro
IPR010139
Domain

Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit H
TIGR01855	$\"[2-199]T$	IMP_synth_hisH

InterPro
IPR011702
Domain

Glutamine amidotransferase superfamily
PR00096	$\"[74-85]T$ $\"[177-190]T$	GATASE

InterPro
IPR012998
Active_site

Glutamine amidotransferase, class I, active site
PS00442	$\"[74-85]T$	GATASE_TYPE_I

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.880	$\"[2-198]T$	G3DSA:3.40.50.880
PIRSF000495	$\"[1-201]T$	Amidotransf_hisH
PTHR21235	$\"[52-200]T$	PTHR21235
PTHR21235:SF1	$\"[52-200]T$	PTHR21235:SF1
SSF52317	$\"[2-200]T$	SSF52317

","BeTs to 10 clades of COG0118COG name: Glutamine amidotransferase (HisH)Functional Class: EThe phylogenetic pattern of COG0118 is amt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000991 (Glutamine amidotransferase class-I) with a combined E-value of 3.2e-11. IPB000991A 74-83 IPB000991B 175-185***** IPB001674 (GMP synthase C terminal domain) with a combined E-value of 6.5e-09. IPB001674A 2-28 IPB001674B 74-83 IPB001674D 176-197","Residues 21-103 are 53% similar to a (AMIDOTRANSFERASE BIOSYNTHESIS COMPLETE PROTEOME) protein domain (PD006254) which is seen in HIS5_LACLA.Residues 35-103 are 53% similar to a (CTP AMIDOTRANSFERASE LIGASE BIOSYNTHESIS) protein domain (PD137961) which is seen in HIS5_SYNY3.Residues 116-199 are 44% similar to a (AMIDOTRANSFERASE BIOSYNTHESIS HISTIDINE) protein domain (PD329941) which is seen in HIS5_METTH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 16:22:01 2002","Wed Apr 24 15:02:07 2002","Thu Oct 17 15:22:28 2002","Wed Feb 27 09:43:56 2002","Wed Feb 27 09:43:56 2002","Wed Feb 27 09:43:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1158 is paralogously related (blast p-value < 1e-3) to SMu0974,a predicted GMP synthase and SMu0484, a predicted anthranilate synthase component II .","Wed Feb 27 09:46:36 2002","","No significant hits to the NCBI PDB database.","SMU.1266c","","Residues 3 to 200 (E-value = 9.2e-42) place SMu1158 in the GATase family which is described as Glutamine amidotransferase class-I (PF00117)","Wed Feb 27 09:43:56 2002","","","","Delorme,C., Ehrlich,S.D. and Renault,P.Histidine biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6571-6579 (1992)PubMed: 1400209","","Wed Feb 27 09:43:56 2002","1","","11","SMU.1266c","" "SMu1159","1197476","1197114","363","GTGAATTCCGTGAGAAAAATTTTTTCAAGTTTGACACTTCTTTTTCGTTTTGTCTTGGAGGTTTCGGCAATAATTGGTTTAGCCGCAGCAGCATTTTGTGAGTACAGTCTGGTGGTCAGAGTTTTATATCCTTTCTTGGGACTGATTATTGCTCTCGTTTGGTCTCGCTATGGTGCTCCGAAATCTACCAATAGCCTGAAAGGAAGAGCTAAATTCGCTCTGGAATGTTTCGTCTACGGTCTGACCATTTTCTGTTTTGCGATGATTTATGATCAAACTTTTACTCTTATTTTTGCGCTGATAGTAGTCATTGATTTAACTGCTATGTATGCTTTGGATTTAGAGAGAAAGGAGACCTTATGA","8.80","2.84","13462","MNSVRKIFSSLTLLFRFVLEVSAIIGLAAAAFCEYSLVVRVLYPFLGLIIALVWSRYGAPKSTNSLKGRAKFALECFVYGLTIFCFAMIYDQTFTLIFALIVVIDLTAMYALDLERKETL","1197129","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu1159 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PD355181	$\"[16-107]T$	Q73A70_BACC1_Q73A70;
signalp	$\"[1-30]?$	signal-peptide
tmhmm	$\"[13-33]?$ $\"[37-55]?$ $\"[70-90]?$ $\"[96-114]?$	transmembrane_regions

InterPro
IPR000807
Domain

Imidazole glycerol-phosphate dehydratase
PD002282	$\"[8-194]T$	IGPD
PF00475	$\"[31-175]T$	IGPD
PS00954	$\"[61-74]T$	IGP_DEHYDRATASE_1
PS00955	$\"[156-168]T$	IGP_DEHYDRATASE_2

noIPR
unintegrated

unintegrated
G3DSA:3.30.230.40	$\"[2-89]T$ $\"[90-194]T$	G3DSA:3.30.230.40
PTHR23133	$\"[1-194]T$	PTHR23133
PTHR23133:SF2	$\"[1-194]T$	PTHR23133:SF2
SSF54211	$\"[1-86]T$ $\"[87-180]T$	SSF54211

","BeTs to 10 clades of COG0131COG name: Imidazoleglycerol-phosphate dehydrataseFunctional Class: EThe phylogenetic pattern of COG0131 is amt-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000807 (Imidazoleglycerol-phosphate dehydratase) with a combined E-value of 1.8e-65. IPB000807A 2-18 IPB000807B 29-63 IPB000807C 81-114 IPB000807D 148-177 IPB000807E 183-194","Residues 80-175 are 54% similar to a (HISTIDINE BIOSYNTHESIS) protein domain (PD002282) which is seen in HIS7_LACLA.Residues 80-193 are 33% similar to a (IGPD LYASE IMIDAZOLEGLYCEROL-PHOSPHATE) protein domain (PD239061) which is seen in Q9SMA0_ORYSA.Residues 6-80 are 39% similar to a (IGPD LYASE IMIDAZOLEGLYCEROL-PHOSPHATE) protein domain (PD392340) which is seen in HIS7_THEMA.Residues 38-77 are 67% similar to a (BIOSYNTHESIS HISTIDINE) protein domain (PD402968) which is seen in HIS7_CANGA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:25:00 2002","Wed Feb 27 09:53:35 2002","Thu Oct 17 15:25:00 2002","Wed Feb 27 09:49:32 2002","Wed Feb 27 09:49:32 2002","Wed Feb 27 09:49:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1160 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 09:53:35 2002","","No significant hits to the NCBI PDB database.","SMU.1268c","","Residues 31 to 175 (E-value = 2.4e-90) place SMu1160 in the IGPD family which is described as Imidazoleglycerol-phosphate dehydratase (PF00475)","Wed Feb 27 09:49:32 2002","","","","Fani,R., Bazzicalupo,M., Damiani,G., Bianchi,A., Schipani,C.,Sgaramella,V. and Polsinelli,M.Cloning of histidine genes of Azospirillum brasilense: organization of the ABFH gene cluster and nucleotide sequence of the hisB geneMol. Gen. Genet. 216 (2-3), 224-229 (1989)PubMed: 2664449","","Wed Feb 27 09:56:13 2002","1","","11","SMU.1268c","" "SMu1161","1198711","1198064","648","ATGACAAAAACTAAGGGACTTTTGGTCATGGATGTTGACTCTACCCTTGTTCAGGAAGAAGTCATTGATCTTCTTGGAGATGAGGCTGGAGTTGGTCAGCAAGTTGCCGATATTACCGAGCGGGCCATGCGAGGGGAGTTGGACTTTCGTCAGGCACTTGAGGAGCGTGTGGCAACCTTGGAAGGATTACCAGAATCTATTTTTGACAAGGTTTATGCCCGCATTCATTTCAATAAAAATGCCAAGGAATTGGTGGCGGAATTGCATGCGCGTGGTTACAAAGTCGGTCTGGTTTCAGGTGGCTTTCATGAGACAGTCGACAGATTAGCAGCAGAAGCTGGCATTGATTATGTTAAGGCTAACCATTTAGAAGTTGTTGATGGTGTCCTGACTGGCAAAACATACGGAGATATTGTGACCAAGGAAATCAAAGTACAAAAGCTCCGCGATTGGGCAGCAGAAAATGAACTTGTCCTTTCACAAACCATTGCCATGGGTGATGGTGCCAATGACTTGCCCATGATTCATGAGGCAGGAATCGGTATTGCCTTTTGTGCCAAACCAATTGTCCGCCAACAAGCACCCTACCAAATCAATGAACCAGATTTGTACAAAGTGATTGAAATATTAGATGAGGTGAAAAAATGA","4.70","-11.83","23687","MTKTKGLLVMDVDSTLVQEEVIDLLGDEAGVGQQVADITERAMRGELDFRQALEERVATLEGLPESIFDKVYARIHFNKNAKELVAELHARGYKVGLVSGGFHETVDRLAAEAGIDYVKANHLEVVDGVLTGKTYGDIVTKEIKVQKLRDWAAENELVLSQTIAMGDGANDLPMIHEAGIGIAFCAKPIVRQQAPYQINEPDLYKVIEILDEVKK","1198079","For other 'ser' genes see SMu1505 (serA); SMu1508 (serC) and SMu1714 (serS).","phosphoserine phosphatase","Cytoplasm","Several matches in gapped BLAST to phosphoserine phosphatase: residues 5-213 are 58% similar to the enzyme in Lactococcus lactis (gi|15672587|). Residues 3-210 are 49% similar to the protein from S.coelicolor (gi|7481185|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0625 (1e-73).","

InterPro
IPR001757
Family

ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119	$\"[91-101]T$ $\"[165-184]T$	CATATPASE

InterPro
IPR004469
Domain

Phosphoserine phosphatase SerB
TIGR00338	$\"[1-210]T$	serB

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[5-188]T$	Hydrolase

InterPro
IPR006383
Domain

HAD-superfamily hydrolase, subfamily IB, PSPase-like
TIGR01488	$\"[7-178]T$	HAD-SF-IB

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[62-211]T$	G3DSA:3.40.50.1000
PTHR10000	$\"[7-210]T$	PTHR10000
SSF56784	$\"[4-209]T$	SSF56784

","BeTs to 8 clades of COG0560COG name: Phosphoserine phosphataseFunctional Class: EThe phylogenetic pattern of COG0560 is amtky---e-Rhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000150 (Cof protein) with a combined E-value of 3.8e-07. IPB000150A 4-18 IPB000150C 163-195","Residues 81-201 are 42% similar to a (PROTEOME COMPLETE HYDROLASE PHOSPHATASE DEHALOGENASE) protein domain (PD000816) which is seen in Q9CBQ6_MYCLE.Residues 8-79 are 62% similar to a (PHOSPHATASE PHOSPHOSERINE PROTEOME) protein domain (PD005736) which is seen in Q9CHW3_LACLA.Residues 85-191 are 62% similar to a (PROTEOME COMPLETE HYDROLASE ATPASE) protein domain (PD001342) which is seen in Q9CHW3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:25:46 2002","Wed Feb 27 09:59:56 2002","Thu Oct 17 15:25:46 2002","Wed Feb 27 09:59:56 2002","Wed Feb 27 09:59:56 2002","Wed Feb 27 09:59:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1161 is paralogously related (blast p-value < 1e-3) to SMu0461,a predicted conserved hypothetical protein, possible hydrolase; SMu0386, a predicted copper-transporting ATPase; and SMu1012, a predicted conserved hypothetical protein.","Thu Mar 21 14:28:23 2002","","No significant hits to the NCBI PDB database.","SMU.1269c","","Residues 5 to 188 (E-value = 5.5e-18) place SMu1161 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Wed Feb 27 09:59:56 2002","","","","Neuwald,A.F. and Stauffer,G.V.DNA sequence and characterization of the Escherichia coli serB geneNucleic Acids Res. 13 (19), 7025-7039 (1985)PubMed: 2997734Neuwald,A.F. and Stauffer,G.V.An Escherichia coli membrane protein with a unique signal sequenceGene 82 (2), 219-228 (1989)PubMed: 2684780","","Wed Feb 27 10:04:50 2002","1","","11","SMU.1269c","658" "SMu1162","1199981","1198698","1284","ATGAAACGTTTAACAGGAACAAATGAAAAGATTTCTAACATTTTATATCAAGAGCAGCTGGAACTCAGCAAGGAAAATTTAGATGTTGAAGCGACTGTTCGTGAGATTATCGAAAAAGTTAAAGAAGAAGGTGATGAGGCTTTACGAGCTTATTCTGAAAAATTTGATCATGTTGTATTATCCGAATTGCACGTTTCGGATCAAGTTGTCAATGAAGCTTTTGACAAGATTGATAAAGATGTTCTCACAGCACTTGAAAATGCAAAAGCTAATATTGAATCCTACCATAAGCAACAATTAAAAGGAGGTTTTGAAGATCAGCCCTCTCAAGGGGTGCTTCGCGGACAGCTGATTCGTCCCATTGAGCGCGTTGGTGTCTATGTTCCCGGTGGAACAGCAGCTTATCCATCATCTGTACTCATGAATGTTATTCCAGCTAAAATTGCTGGTGTGAAAGAAATCATTATGATTACACCGCCGCAGGAACATTTTGTCCCAGCTATTTTGGTTGCTGCCAAACTGGCCGGTGTTGATAAAATTTATCAGGTTGGCGGTGCCCAAGGAATTGCAGCTTTGGCTTATGGCACACAAACACTGCCTAAAGTGGATAAGATTACAGGCCCGGGCAATATCTTTGTAGCAACTGCTAAAAAGTTGGTTTATGGTGTGGTAGGCATTGATATGATTGCTGGACCATCGGAAATTGGTGTCATCGCAGATAGTACAGCCAATCCTGTTTATGTGGCTGCTGATTTGCTGTCTCAAGCAGAACATGATGTCCATGCCCGTGCTATTCTCGTGACTAACTCAGCTGAATTGGCTGATGCGGTTGAATTAGAAATTGAAAAGCAGTTGCAAACCTTGCCACGTCAGGCTATCGCTCGTCCTTCAATTGAAAATAATGGTCGAATTATTATTGCCCAAGATGTGGAGAGCATGTTTGAACTCATGAATTTAGTGGCGCCAGAGCACTTAGAAATTGCTATAGATAAAGCTTATGATTATTTGGAACGAGTGCAAAATGCTGGTTCGATTTTCCTTGGACATTACACCAGTGAACCAATTGGTGATTATTATGCTGGTGCCAACCATGTGCTGCCGACAACAGCTACCAGTCGTTTTTCATCAGCACTTGGTGTGCATGACTTTGTCAAACGCATCCAATACACGCAATACAGTAAGGCTGCCGTTAATGCAGCTGAAAAAGACATTACAACCCTTGCCTATGCCGAAGGTTTGCAGGCACATGCCAGAGCAATTGAGGTGAGAAATGACAAAAACTAA","5.00","-14.31","46439","MKRLTGTNEKISNILYQEQLELSKENLDVEATVREIIEKVKEEGDEALRAYSEKFDHVVLSELHVSDQVVNEAFDKIDKDVLTALENAKANIESYHKQQLKGGFEDQPSQGVLRGQLIRPIERVGVYVPGGTAAYPSSVLMNVIPAKIAGVKEIIMITPPQEHFVPAILVAAKLAGVDKIYQVGGAQGIAALAYGTQTLPKVDKITGPGNIFVATAKKLVYGVVGIDMIAGPSEIGVIADSTANPVYVAADLLSQAEHDVHARAILVTNSAELADAVELEIEKQLQTLPRQAIARPSIENNGRIIIAQDVESMFELMNLVAPEHLEIAIDKAYDYLERVQNAGSIFLGHYTSEPIGDYYAGANHVLPTTATSRFSSALGVHDFVKRIQYTQYSKAAVNAAEKDITTLAYAEGLQAHARAIEVRNDKN","1198713","For other 'his' genes see SMu1153 (hisE); SMu1155 (hisE),(hisI); SMu1156 (hisF);SMu1157 (hisA);SMu1158 (hisH); SMu1160 (hisB); SMu1163 (hisG); SMu1164 (hisZ) and SMu1165 (hisC). From Genbank:[gi:13432185]This protein is considered a bifunctional enzyme, possessing two active sites, one an alcohol dehydrogenase and the other an aldehyde dehydrogenase.","histidinol dehydrogenase","Cytoplasm","Several matches in gapped BLAST to histidinol dehydrogenases: residues 1-423 are 59% similar to the enzyme in Listeria monocytogenes (gi|16802610|). Residues 6-426 are 50% similar to the protein from Lactococcus lactis (gi|15673191|).SMu1162 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001692
Domain

Histidinol dehydrogenase
PD002680	$\"[29-423]T$	Histidinol_dh
PR00083	$\"[33-57]T$ $\"[134-160]T$ $\"[167-193]T$ $\"[197-222]T$ $\"[226-247]T$ $\"[248-267]T$ $\"[317-342]T$ $\"[358-376]T$	HOLDHDRGNASE
PF00815	$\"[11-425]T$	Histidinol_dh
TIGR00069	$\"[11-427]T$	hisD
PS00611	$\"[226-258]T$	HISOL_DEHYDROGENASE

InterPro
IPR012131
Family

Histidinol dehydrogenase, prokaryotic
PIRSF000099	$\"[1-427]T$	Histidinol_dh
PTHR21256:SF2	$\"[31-424]T$	Hstdl_DH_prok

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.10270	$\"[25-236]T$	G3DSA:3.40.50.10270
PTHR21256	$\"[31-424]T$	PTHR21256
SSF53720	$\"[1-426]T$	SSF53720

","BeTs to 10 clades of COG0141COG name: Histidinol dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0141 is amt-yqvCebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001692 (Histidinol dehydrogenase) with a combined E-value of 3.5e-147. IPB001692A 33-58 IPB001692B 77-99 IPB001692C 120-160 IPB001692D 180-217 IPB001692E 226-268 IPB001692F 341-385 IPB001692G 388-423","Residues 21-425 are 51% similar to a (DEHYDROGENASE HISTIDINOL HISTIDINE) protein domain (PD002680) which is seen in HISX_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:26:27 2002","Wed Feb 27 10:10:24 2002","Thu Oct 17 15:26:27 2002","Wed Feb 27 10:10:24 2002","Wed Feb 27 10:10:24 2002","Wed Feb 27 10:10:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1162 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 10:10:50 2002","","No significant hits to the NCBI PDB database.","SMU.1270c","","Residues 17 to 425 (E-value = 2.1e-204) place SMu1162 in the Histidinol_dh family which is described as Histidinol dehydrogenase (PF00815)","Wed Feb 27 10:10:24 2002","","","","Delorme,C., Ehrlich,S.D. and Renault,P.Histidine biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6571-6579 (1992)PubMed: 1400209","","Wed Feb 27 10:10:24 2002","1","","11","SMU.1270c","" "SMu1163","1200625","1199978","648","ATGACAAAACAATTAACCATTGCCTTGACAAAAGGGCGAATTGAAAAGGATACGGTCAAATTACTTGAAAGAGCGGGTTTTGACATGTCCTTCATGGCTGATAAGGGCCGTAATCTGATTTTTGAAAGTCCAGATAAAAGCTTTCGTTTTCTGCTTGTTAAGGCACCAGATGTCACAACCTATGTTCGTCATGGTGTAGCTGATATTGGTGTTGTGGGAAAAGATGTTCTGATCGAACATCCGACAGGTTACTTGGAAATGCTGGATCTCAATTTTGGACTTTGCAAATTTTCAGTAGCCTCCACACCAGATTATAATCCTAGTGATCATAAACGCAAGCGGATTGCAACCAAATATCCAACAGTTGCCAGAGACTTTTTCAATCAAAAAGGGGAGGATGTTGAGATTATTTCTATTCAAGGAAGTGTGGAAATTGCCCCTGTTATTGGTTTAGCGGATGCCATTGTCGATATTGTTGAGACAGGCAATACACTAGTCGCTAATGGCTTGGAAGTCTTTGAAGATATTTGTCGTATTTCAGCTCGCATGATTGTCAATAAGGCCAGTTTAAAAAATAAACCAGAATTATTGGCTTTCATCAAGAAAATGGAAAACCTTGTCGGTGATAGAGAGGTGGCTTTTAAATGA","7.40","0.63","23894","MTKQLTIALTKGRIEKDTVKLLERAGFDMSFMADKGRNLIFESPDKSFRFLLVKAPDVTTYVRHGVADIGVVGKDVLIEHPTGYLEMLDLNFGLCKFSVASTPDYNPSDHKRKRIATKYPTVARDFFNQKGEDVEIISIQGSVEIAPVIGLADAIVDIVETGNTLVANGLEVFEDICRISARMIVNKASLKNKPELLAFIKKMENLVGDREVAFK","1199993","For other 'his' genes see SMu1153 (hisE); SMu1155 (hisE),(hisI); SMu1156 (hisF);SMu1157 (hisA);SMu1158 (hisH); SMu1160 (hisB); SMu1162 (hisD); SMu1164 (hisZ) and SMu1165 (hisC). ","ATP phosphoribosyltransferase","Cytoplasm","Several matches in gapped BLAST to ATP phosphoribosyltransferase: residues 3-207 are 63% similar to the enzyme in Listeria monocytogenes (gi|16802611|) and are 57% similar to the protein from Clostridium acetobutylicum (gi|15894223|).SMu1163 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001348
Family

Histidine biosynthesis HisG: ATP phosphoribosyltransferase
PTHR21403	$\"[9-207]T$	ATP_phspho_trans
TIGR00070	$\"[4-215]T$	hisG

InterPro
IPR013820
Domain

ATP phosphoribosyltransferase, catalytic region
PD003516	$\"[86-208]T$	ATP_phspho_trans
PF01634	$\"[53-207]T$	HisG
PS01316	$\"[144-165]T$	ATP_P_PHORIBOSYLTR

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[3-208]T$	G3DSA:3.40.190.10
SSF53850	$\"[5-213]T$	SSF53850

","BeTs to 10 clades of COG0040COG name: ATP phosphoribosyltransferase (histidine biosynthesis)Functional Class: EThe phylogenetic pattern of COG0040 is amT-yqvcebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001348 (ATP phosphoribosyltransferase) with a combined E-value of 7e-38. IPB001348A 4-27 IPB001348B 57-79 IPB001348C 90-102 IPB001348D 139-170 IPB001348E 173-190","Residues 54-205 are 56% similar to a (TRANSFERASE ATP PHOSPHORIBOSYLTRANSFERASE) protein domain (PD003516) which is seen in HIS1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:26:55 2002","Wed Feb 27 10:14:23 2002","Thu Oct 17 15:26:55 2002","Wed Feb 27 10:14:23 2002","Wed Feb 27 10:14:23 2002","Wed Feb 27 10:14:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1163 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 10:14:23 2002","","No significant hits to the NCBI PDB database.","SMU.1271c","","Residues 53 to 207 (E-value = 3.4e-63) place SMu1163 in the HisG family which is described as ATP phosphoribosyltransferase (PF01634)","Wed Feb 27 10:14:23 2002","","","","Delorme,C., Ehrlich,S.D. and Renault,P.Histidine biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6571-6579 (1992)PubMed: 1400209Sissler,M., Delorme,C., Bond,J., Ehrlich,S.D., Renault,P. andFrancklyn,C.An aminoacyl-tRNA synthetase paralog with a catalytic role inhistidine biosynthesisProc. Natl. Acad. Sci. U.S.A. 96 (16), 8985-8990 (1999)PubMed: 10430882","","Wed Feb 27 10:15:55 2002","1","","11","SMU.1271c","" "SMu1164","1201597","1200635","963","ATGAAGAAAACAAGTTTACCAGTTGGCATGCACGATAAGCTCTTCAAGCGAGCACGTGTCATGTATGAGATTGAGCGAGATATTAGTAATCTTTTAATTAAACAAGGTTTTAATCGCATTGAGACGCCTACTTTGGAACATTTTGAAGTTTTTGCGGATGACGTTTCTTCTGAGCATTACCACCTTTTTGATAAGAAAGGAAATCTCCTCAGTCTGCGTCCCGACATTACCAGCCAAATCGGTCGCGTCATTGCTTCGACACGTGTTGAAACACCGATTAAGTTCTCTTATTCGGGCAAGGTTTTCAAGTATAATGAGGAGCTGCGCGGTTTGGCCAATGAGCACACACAAGCAGGTATTGAAATTGTTGGCTACAAGACTCAAGATGCCATTAAAGATGCTCTGCTTTCAGCTAAAGATGCTTTGAAAGCCAGTGGTTTAAAAGATTATAAATTTGAATTTTCTCATGCACATATCTTGCAGACCATTTTTGCAAATTTAGACATTCCTGAAACTGCTAAGAAAGAGTTAACAACTTTCATTCAAGATAAAAATATCACAGGTCTTAACGAATTTACCCATCGTTACCCTAGTGAATTTAATGCTCTTATCAGACAGCTTCCTTTTCTTTTTGGGGAGAGTCATCAGGTCTTGAAAAAAGCTCGCCAGTTAACTAATCATCAGACAATCTTATCAGCCCTGACTGATTTGGAAGACTTGTTGCAAGAACTGGCGGTTTCATTGGCAGAGATTACTTTGGATTTGGCACAAATTGCTAGTATGCCTTATTATACGGGACTTATGTTCAAGGTATTTGGCGATAAGATTCCAGATGCTTTTGTATCAGGTGGTCGCTATGATAAGCTGTTTGAGCGTTTTGGTGCTAAAGAATTAACAGCCATCGGTTGGGCACTTGATATTGATAGTGTTTATCAGGCTATCCATGATCACATTCGCTTTTAG","6.80","-1.09","36435","MKKTSLPVGMHDKLFKRARVMYEIERDISNLLIKQGFNRIETPTLEHFEVFADDVSSEHYHLFDKKGNLLSLRPDITSQIGRVIASTRVETPIKFSYSGKVFKYNEELRGLANEHTQAGIEIVGYKTQDAIKDALLSAKDALKASGLKDYKFEFSHAHILQTIFANLDIPETAKKELTTFIQDKNITGLNEFTHRYPSEFNALIRQLPFLFGESHQVLKKARQLTNHQTILSALTDLEDLLQELAVSLAEITLDLAQIASMPYYTGLMFKVFGDKIPDAFVSGGRYDKLFERFGAKELTAIGWALDIDSVYQAIHDHIRF","1200650","For other 'his' genes see SMu1153 (hisE); SMu1155 (hisE),(hisI); SMu1156 (hisF);SMu1157 (hisA);SMu1158 (hisH); SMu1160 (hisB); SMu1162 (hisD); SMu1163 (hisG) and SMu1165 (hisC). From Genbank:[gi:7674068]This protein may allow the regulation of ATP phosphoribosyltransferase activity by histidine.","histidyl-tRNA synthetase","Cytoplasm","Several matches in gapped BLAST to histidyl-tRNA synthetase: residues 5-310 are 39% similar to the enzyme in Listeria innocua (gi|16799653|) and are 31% similar to the protein from Clostridium acetobutylicum (gi|15894222|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2108 (6e-12).","

InterPro
IPR002314
Domain

tRNA synthetase, class II (G, H, P and S)
PF00587	$\"[20-177]T$	tRNA-synt_2b

InterPro
IPR004516
Family

Histidyl-tRNA synthetase, class IIa
PIRSF001549	$\"[2-318]T$	His-tRNA_synth

InterPro
IPR015805
Family

Histidyl-tRNA synthetase
PTHR11476	$\"[7-319]T$	His-tRNA_synth

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[2-314]T$	G3DSA:3.30.930.10
SSF55681	$\"[3-316]T$	SSF55681

InterPro
IPR004839
Domain

Aminotransferase, class I and II
PF00155	$\"[20-344]T$	Aminotran_1_2

InterPro
IPR005861
Family

Histidinol-phosphate aminotransferase
TIGR01141	$\"[2-347]T$	hisC

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[44-253]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015422
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 2
G3DSA:3.90.1150.10	$\"[254-349]T$	PyrdxlP-dep_Trfase_major_sub2

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[7-348]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[36-348]T$	PTHR11751
PTHR11751:SF3	$\"[36-348]T$	PTHR11751:SF3

","BeTs to 10 clades of COG0079COG name: Histidinol-phosphate aminotransferaseFunctional Class: EThe phylogenetic pattern of COG0079 is AmtkyqvCebRH---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 61-251 are 48% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9HVX0_PSEAE.Residues 71-331 are 24% similar to a (Y4RO ERYTHROCYTE HEMOLYSIN PLASMID) protein domain (PD040058) which is seen in O68622_PREIN.Residues 187-252 are 42% similar to a (AMINOTRANSFERASE PHOSPHATE) protein domain (PD306181) which is seen in HIS8_HAEIN.Residues 5-53 are 48% similar to a (AMINOTRANSFERASE PHOSPHATE) protein domain (PD090127) which is seen in HIS8_ACEPA.Residues 191-254 are 46% similar to a (AMINOTRANSFERASE PHOSPHATE) protein domain (PD256540) which is seen in HIS8_BACSU.Residues 263-333 are 47% similar to a (AMINOTRANSFERASE HISTIDINOL-PHOSPHATE) protein domain (PD164716) which is seen in HIS8_SYNY3.Residues 231-333 are 42% similar to a (AMINOTRANSFERASE PHOSPHATE ACETOL-) protein domain (PD167560) which is seen in HIS8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 24 09:27:05 2005","Wed Feb 27 10:29:15 2002","Tue May 24 09:27:05 2005","Wed Feb 27 10:29:15 2002","","Wed Feb 27 10:29:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1165 is paralogously related (blast p-value < 1e-3) to SMu1199,a predicted aspartate aminotransferase; SMu1663,a predicted aminotransferase, class I; and SMu0582, a predicted transcriptional regulator.","Wed Feb 27 10:31:28 2002","","No significant hits to the NCBI PDB database.","SMU.1273c","","Residues 64 to 348 (E-value = 1.2e-38) place SMu1165 in the Aminotran_1_2 family which is described as Aminotransferase class I and II (PF00155)","Wed Feb 27 10:29:15 2002","","","","Delorme,C., Ehrlich,S.D. and Renault,P. Histidine biosynthesis genes in Lactococcus lactis subsp. lactis J. Bacteriol. 174 (20), 6571-6579 (1992) PubMed: 1400209 Sissler,M., Delorme,C., Bond,J., Ehrlich,S.D., Renault,P. and Francklyn,C. An aminoacyl-tRNA synthetase paralog with a catalytic role in histidine biosynthesis Proc. Natl. Acad. Sci. U.S.A. 96 (16), 8985-8990 (1999) PubMed: 10430882 ","","Wed Feb 27 10:31:28 2002","1","","11","SMU.1273c","" "SMu1166","1205541","1203817","1725","ATGTCTAGCGGAATTGTATTGCTGATAGTGGCAATTGTATTGGTAGTGATTATTGCCTATCTTATTGCTATTATTATCAGAAAACGAAATGATTCGTTAATCACAAAATTGGAAGAACGCAAACAAAATCTTTTTGATTTGCCCGTCAATGATGAAATTGAAGAAGTAAAAAAACTGCATTTGATTGGTCAAAGTCAAACGACTTTTCGTGAATGGAATCAAAAATGGGTTGATTTGTCACTCAATTCATTTAGTGATATTGAAAATCATATTTTTGAAGCAGAAAACCTTAATGATACCTTTAATTTCATTCGTGCTCATAGTCAAATTAATAATATTGAAAGCCAGTTAAATCTAGCAGAAGAAGATATTAAGGCAATCAGAGAAGCACTTGCTGTTTTGAAAGAGCAGGAAGAAAAAAACAGTGCTCGTGTTTTACATGCGCTTGAAATGTATGAAAGTTTGCAAGCTTCTATTGAAGAAGGAGATAGCAATTTTGGTATTACCATGCCTGAAATCGAAAAGCAGCTCAAAAATATTGAAGCTGAATTCTCGCAATTTGTAACTTTAAATTCATCTGGAGATCCTGTTGAAGCATCGGAAATTCTTGATCGTGCTGAAGAACATACCATTGCTCTTGGGCAAATGACGGAGAAAATTCCTGCTATTGTGGCTAAATTGGAAGATGATTTCCCAGATCAATTGGATGATTTGGAATCAGGCTACCGCCGTCTTTTGGAAGAAAATTATCATTTCCCTGAAAAGAATATTGAGGAACGTTTTCAAGAAGTTCGTGAAGCTATTGGCAATAACTCCAATGAACTTGTCTCCCTAGATCTTGATAAGGCTGAGTCTGAAAATGAAGCGATTCAGGAAAAAATTGATTCTCTTTATGATATTTTTGAACGTGAAATTCGTGCGCATAAGAATATTGTCAAAAGCAAAAAGATTATCCCGGCTTACTTGGAACATGCCAAGAAAAATAATGAGCAGTTAGAAGCGGAAATTGAGCGTCTCAATCACAGATATATCTTAAATGAAAAAGAAGAACTCAATGTGCGTGACTTTAATGAAGAAATAGCTAGTGTAGAAAAAGATGTCTTGCCGATTATTGAGAATTTTGATACTCAAGAAAAACCATTCTCTGTTTTGGAAGACAAATTTGATCGTGCTATTAAGAAACTTGACCTTGTTGAAGAAGGTCAGCTGGATGTTTTTAATAGCTTAAAAAACATTGAAAATGTTGAAAAGACGGCACGTCAGAAATTAGATAGCTATATTAATCGGCTTCATGCCATTAAACGTTTTATGGAAAAACGCAATTTGCCTGGTATTCCGCAAGATTTTCTCAGTGTTTTCTTTACAACAAGTGCTCAGTTAGAAGCCTTAATGGATGAGTTGAATCGTGCTCGTATTCATATTGAAACTGTTAATCGGATGACAGAAGCAGCGACAGCAGCTGTAGAAAATTTGGAAGAAACGGCTTATCGTGTTGTTCAAAATGCAACACTGACAGAGCAATTGCTGCAATATTCAAACCGTTACCGCAGTTTTGAACCAAGTGTTCAAGAAAGCTTTGATATTGCCCTTAAGCTCTTTGAAACTGATTATGACTACCAAGGTTCTTTTGATGAAATTTCTTATTCTTTAGAGACAGTAGAACCCGGCGTTACTGATCGTTTTGTTTCTTCTTATGAAAAAACGCGTGAAACCATTCGATTTTAA","4.50","-45.22","66574","MSSGIVLLIVAIVLVVIIAYLIAIIIRKRNDSLITKLEERKQNLFDLPVNDEIEEVKKLHLIGQSQTTFREWNQKWVDLSLNSFSDIENHIFEAENLNDTFNFIRAHSQINNIESQLNLAEEDIKAIREALAVLKEQEEKNSARVLHALEMYESLQASIEEGDSNFGITMPEIEKQLKNIEAEFSQFVTLNSSGDPVEASEILDRAEEHTIALGQMTEKIPAIVAKLEDDFPDQLDDLESGYRRLLEENYHFPEKNIEERFQEVREAIGNNSNELVSLDLDKAESENEAIQEKIDSLYDIFEREIRAHKNIVKSKKIIPAYLEHAKKNNEQLEAEIERLNHRYILNEKEELNVRDFNEEIASVEKDVLPIIENFDTQEKPFSVLEDKFDRAIKKLDLVEEGQLDVFNSLKNIENVEKTARQKLDSYINRLHAIKRFMEKRNLPGIPQDFLSVFFTTSAQLEALMDELNRARIHIETVNRMTEAATAAVENLEETAYRVVQNATLTEQLLQYSNRYRSFEPSVQESFDIALKLFETDYDYQGSFDEISYSLETVEPGVTDRFVSSYEKTRETIRF","1203832","From Genbank:[gi:7674023]This protein is a negative regulator of FTSZ ring formation;it modulates the frequency and position of FTSZ ring formation.It inhibits FTSZ ring formation at polar sites.It interacts either with FTSZ or with one of its binding partners to promote depolymerization.","cell division regulator","Cytoplasm, Membrane, Extracellular","Matches in gapped BLAST to conserved hypothetical protein / and to cell division regulator: residues 27-574 are 73% similar to the conserved hypothetical protein in S.pyogenes (gi15674783) and are 54% similar to the protein from S.pneumoniae (gi15902760). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0624 (0.0).","

InterPro
IPR010379
Family

Septation ring formation regulator, EzrA
PF06160	$\"[6-567]T$	EzrA

noIPR
unintegrated

unintegrated
SSF46966	$\"[84-229]T$	Spectrin

","BeTs to 3 clades of COG0419COG name: ATPase involved in DNA repairFunctional Class: LThe phylogenetic pattern of COG0419 is amtkyqvceb------ol---Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 256-571 are 37% similar to a (PROTEOME COMPLETE REGULATOR DIVISION) protein domain (PD401585) which is seen in Q9CDR6_LACLA.Residues 27-250 are 52% similar to a (SEPTATION CELL REGULATOR DIVISION) protein domain (PD131909) which is seen in Q9CDR6_LACLA.Residues 275-482 are 24% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in EZRA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 11:02:01 2002","Wed Feb 27 10:52:40 2002","Thu Jul 27 10:49:42 2006","Wed Feb 27 10:52:40 2002","","Wed Feb 27 10:52:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1166 is paralogously related (blast p-value < 1e-3) to SMu1375, a predicted chromosome segregation SMC protein.","Wed Feb 27 11:03:31 2002","","No significant hits to the NCBI PDB database.","SMU.1276c","","No significant hits to the Pfam 11.0 database","Wed Feb 27 10:52:40 2002","24379695","","","Levin,P.A., Kurtser,I.G. and Grossman,A.D.Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilisProc. Natl. Acad. Sci. U.S.A. 96 (17), 9642-9647 (1999)PubMed: 10449747","","Wed Feb 27 11:02:01 2002","1","","","SMU.1276c","69" "SMu1167","1207589","1205637","1953","ATGACAGAAGAAAATAAAAATTTAGATCAATTAGCACAAGAGTACGATGCCAGTCAAATTCAGGTTTTGGAAGGACTTGAAGCTGTTCGTATGCGTCCAGGGATGTACATTGGTTCAACTTCAAAAGAAGGGCTGCATCATCTTGTTTGGGAAATTGTTGACAACTCCATTGATGAAGCTTTGGCAGGCTTTGCCAGTCACATTCAAGTTTTCATTGAAGAGGACAATTCTATTACGGTTATTGATGATGGTCGCGGCATTCCAGTTGATATTCAGCAAAAAACAGGTCGTCCAGCTGTAGAAACCGTCTTTACTGTTCTCCATGCAGGAGGGAAATTCGGCGGCGGCGGTTATAAGGTATCTGGAGGCCTTCACGGTGTTGGTTCTTCTGTCGTTAATGCTCTTTCAACACAGTTGGATGTTCGTGTCCATAAGAATGGCAAGATTCATTATCAAGAGTATCATCGCGGAGTGGTTGCTGAAGATTTAAAAGTCATTGGTGATACAGATATTACTGGAACGATTGTTCACTTCACACCAGATCCTGAGATTTTTACGGAAACAACTGAATTTGATTTTGATAAATTAGCCAAACGTATTCAAGAGCTTGCTTTCTTGAATAAGGGTTTGAAAATTTCAATTACCGATAAACGCTCTGGACAAGAAAGAAAAGAAGAATTTCACTATGAGGGCGGTATTGTCAGTTATGTAGAATTCATCAATGAAAATAAAGAAGTTATTTTTGATAAACCGATTTATACGGATGGTTCTTTGGATGGTATTTCTGTCGAAGTAGCCATGCAATACACAACTGGTTTTCATGAAAATATCATGAGTTTTGCCAATAATATTCACACTCATGAAGGTGGAACGCATGAACAAGGATTCCGTACGGCTCTGACACGTGTTATCAATGATTACGCCAAGAAAAATAAAATCCTTAAAGAAAATGAGGATAATTTAAACGGTGACGATGTTCGTGAAGGTTTGACAGCCATCATTTCGGTTAAGCATCCCAATCCGCAGTTTGAAGGACAAACCAAGACCAAACTGGGAAATTCAGAAGTTGTTAAAATTACCAATCGACTTTTCAGTGATGCTCTCAATCGTTTCTTGTTAGAAAACCCCCAAATCGCTAAAAAGATTGTTGAAAAAGGGATACTAGCATCTAAAGCTCGTATTGCGGCTAAAAGAGCGCGTGAAGTGACTCGGAAGAAATCCGGACTTGAAATCTCAAATTTACCGGGCAAATTGGCAGACTGTTCCTCTAATGATCCCATTCAGAATGAACTCTTTATCGTGGAGGGAGATTCAGCTGGCGGTTCTGCTAAGTCTGGCCGTAACCGTGAATTTCAAGCAATCTTGCCTATCCGCGGTAAAATTCTAAATGTTGAAAAAGCTACCATGGATAAGATTTTGGCCAATGAAGAAATCAGAAGTCTCTTCACAGCAATGGGAACAGGTTTTGGGGCAGAATTTGATGTTTCTAAATCGCGCTATCAAAAATTGGTGATTATGACTGATGCTGATGTTGATGGGGCTCATATTAGAACCTTACTTTTGACACTTATTTATCGTTTCATGCGTCCGGTGCTTGAAGCAGGCTATGTCTATATCGCGCAACCGCCTATTTATGGTATTAAGGTTGGCAGTGATATTAAAGAATACATTCAGCCCGGAAATGATCAAGAAGAAAAATTGCAGGAAGCTTTAGAAAAGTACAGTCAAGGACGTTCAAAACCGACCGTTCAGCGCTATAAGGGGCTTGGGGAAATGGATGATCATCAGCTTTGGGAAACAACCATGAATCCGGATAATCGCTTGATGGCACGCGTTTCATTGGACGATGCTGCTGAGGCTGACAAGATATTTGATATGCTTATGGGAGATCGTGTTGAACCTCGTCGTGGTTTTATTGAAGAAAATGCGGTTTATAGTACGCTTGACGTTTAA","5.40","-16.87","72426","MTEENKNLDQLAQEYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLHHLVWEIVDNSIDEALAGFASHIQVFIEEDNSITVIDDGRGIPVDIQQKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVRVHKNGKIHYQEYHRGVVAEDLKVIGDTDITGTIVHFTPDPEIFTETTEFDFDKLAKRIQELAFLNKGLKISITDKRSGQERKEEFHYEGGIVSYVEFINENKEVIFDKPIYTDGSLDGISVEVAMQYTTGFHENIMSFANNIHTHEGGTHEQGFRTALTRVINDYAKKNKILKENEDNLNGDDVREGLTAIISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSDALNRFLLENPQIAKKIVEKGILASKARIAAKRAREVTRKKSGLEISNLPGKLADCSSNDPIQNELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKATMDKILANEEIRSLFTAMGTGFGAEFDVSKSRYQKLVIMTDADVDGAHIRTLLLTLIYRFMRPVLEAGYVYIAQPPIYGIKVGSDIKEYIQPGNDQEEKLQEALEKYSQGRSKPTVQRYKGLGEMDDHQLWETTMNPDNRLMARVSLDDAAEADKIFDMLMGDRVEPRRGFIEENAVYSTLDV","1205652","For other 'gyr' genes see SMu1017 (gyrA). For DNA gyrase A subunit see SMu1017.From Genbank:[gi:1346245]DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catananes and knotted rings.","DNA gyrase subunit B","Cytoplasm","Several matches in gapped BLAST to DNA gyrase subunit B: residues 1-650 are 83% similar to the enzyme in S.pneumoniae (gi1490397) and are 82% similar to the protein from S.pyogenes (gi15674782).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0623 (0.0).","

InterPro
IPR000565
Family

DNA topoisomerase, type IIA, subunit B
PR01159	$\"[15-25]T$ $\"[190-205]T$ $\"[205-218]T$ $\"[231-253]T$ $\"[323-339]T$ $\"[371-385]T$ $\"[385-405]T$ $\"[481-490]T$ $\"[604-616]T$ $\"[620-636]T$	DNAGYRASEB

InterPro
IPR001241
Domain

DNA topoisomerase, type IIA, subunit B or N-terminal
PR00418	$\"[44-59]T$ $\"[79-92]T$ $\"[122-136]T$ $\"[279-292]T$ $\"[431-445]T$ $\"[497-513]T$ $\"[515-532]T$ $\"[535-547]T$ $\"[583-599]T$	TPI2FAMILY
SM00433	$\"[44-644]T$	TOP2c
PS00177	$\"[433-441]T$	TOPOISOMERASE_II

InterPro
IPR002288
Domain

DNA topoisomerase, type IIA, subunit B, C-terminal
PF00986	$\"[574-640]T$	DNA_gyraseB_C

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[12-231]T$	ATP_bd_ATPase
PF02518	$\"[40-183]T$	HATPase_c
SM00387	$\"[40-184]T$	HATPase_c
SSF55874	$\"[14-228]T$	ATP_bd_ATPase

InterPro
IPR006171
Domain

TOPRIM
PF01751	$\"[429-540]T$	Toprim

InterPro
IPR011557
Family

DNA gyrase, subunit B
TIGR01059	$\"[15-650]T$	gyrB

InterPro
IPR011558
Domain

DNA topoisomerase, type IIA, subunit B, conserved region
PD149633	$\"[436-553]T$	DNA_gyrase_B

InterPro
IPR013506
Domain

DNA topoisomerase, type IIA, subunit B, region 2
PF00204	$\"[232-402]T$	DNA_gyraseB

InterPro
IPR013759
Domain

DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta
G3DSA:3.40.50.670	$\"[395-623]T$	Topo_IIA_B/N_ab

InterPro
IPR013760
Domain

DNA topoisomerase, type IIA, central
SSF56719	$\"[405-649]T$	Topo_IIA_cen

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[262-395]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
PTHR10169	$\"[34-645]T$	PTHR10169
PTHR10169:SF3	$\"[34-645]T$	PTHR10169:SF3
SSF54211	$\"[232-403]T$	SSF54211

","BeTs to 14 clades of COG0187COG name: DNA gyrase (topoisomerase II) B subunitFunctional Class: LThe phylogenetic pattern of COG0187 is a---yqvCEBrHujGPOlINXNumber of proteins in this genome belonging to this COG is 2","***** IPB001241 (DNA topoisomerase II family) with a combined E-value of 3.1e-145. IPB001241A 20-41 IPB001241B 118-136 IPB001241C 173-185 IPB001241D 279-292 IPB001241E 325-351 IPB001241F 430-478 IPB001241G 498-524 IPB001241H 584-607","Residues 372-486 are 84% similar to a (TOPOISOMERASE ATP-BINDING DNA SUBUNIT GYRASE DNA-BINDING) protein domain (PD000714) which is seen in Q9CH36_LACLA.Residues 143-216 are 55% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA GYRASE IV COMPLETE) protein domain (PD242130) which is seen in Q9RP84_ACHLA.Residues 488-554 are 85% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA GYRASE PROTEOME IV) protein domain (PD000616) which is seen in Q9CH36_LACLA.Residues 221-256 are 58% similar to a (GYRASE SUBUNIT DNA TOPOISOMERASE) protein domain (PD410611) which is seen in Q9CH36_LACLA.Residues 187-242 are 76% similar to a (GYRASE DNA ATP-BINDING TOPOISOMERASE) protein domain (PD412132) which is seen in Q59957_STRPN.Residues 44-109 are 93% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING GYRASE) protein domain (PD404171) which is seen in Q59957_STRPN.Residues 374-430 are 43% similar to a (GYRASE B PROTEOME ATP-BINDING) protein domain (PD384252) which is seen in Q9RVW5_DEIRA.Residues 15-41 are identical to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA GYRASE IV) protein domain (PD372606) which is seen in Q9CH36_LACLA.Residues 573-640 are 86% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA GYRASE IV PROTEOME) protein domain (PD149633) which is seen in Q59957_STRPN.Residues 375-426 are 73% similar to a (GYRASE DNA ISOMERASE ATP-BINDING) protein domain (PD336367) which is seen in Q59957_STRPN.Residues 243-366 are 87% similar to a (TOPOISOMERASE SUBUNIT ATP-BINDING DNA GYRASE PROTEOME IV) protein domain (PD001260) which is seen in Q59957_STRPN.Residues 44-227 are 72% similar to a (TOPOISOMERASE ATP-BINDING DNA SUBUNIT GYRASE II) protein domain (PD000740) which is seen in GYRB_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jul 27 10:42:01 2006","Thu Jul 27 10:42:01 2006","Thu Jul 27 10:42:01 2006","Wed Feb 27 11:10:21 2002","Wed Feb 27 11:10:21 2002","Wed Feb 27 11:10:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1167 is paralogously related (blast p-value < 1e-3) to SMu1106, a predicted DNA topoisomerase IV.","Wed Feb 27 11:12:53 2002","Thu Jul 27 10:42:01 2006","pdb1EI1A Chain A, Dimerization Of E. Coli Dna Gyrase B Provid... 337 3e-093pdb1AJ6 Novobiocin-Resistant Mutant (R136h) Of The N-Termi... 204 2e-053pdb1BJT Topoisomerase Ii Residues 409 - 1201 >gi1633273p... 80 6e-016","SMU.1277c","","Residues 40 to 183 (E-value = 2.8e-27) place SMu1167 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)Residues 232 to 402 (E-value = 9.6e-96) place SMu1167 in the DNA_gyraseB family which is described as DNA gyrase B (PF00204)Residues 429 to 540 (E-value = 5.5e-09) place SMu1167 in the Toprim family which is described as Toprim domain (PF01751)Residues 574 to 640 (E-value = 5.3e-45) place SMu1167 in the DNA_gyraseB_C family which is described as DNA gyrase B subunit, carboxyl terminus (PF00986)","Thu Jul 27 10:42:01 2006","","","","Munoz,R., Bustamante,M. and de la Campa,A.G.Ser-127-to-Leu substitution in the DNA gyrase B subunit ofStreptococcus pneumoniae is implicated in novobiocin resistanceJ. Bacteriol. 177 (14), 4166-4170 (1995)PubMed: 7608096Holmes,M.L. and Dyall-Smith,M.L.Mutations in DNA gyrase result in novobiocin resistance in halophilic archaebacteriaJ. Bacteriol. 173 (2), 642-648 (1991)PubMed: 1846146","","Wed Feb 27 11:12:08 2002","1","","","SMU.1277c","68" "SMu1168","1208173","1207589","585","ATGAAAGGCATGAATTATCATGATTACATCTGGGATTTAGGCGGAACATTACTGGATAACTATGGTATGTCAACCAAAGCGTTTGTTGCGACTTTAGCTGATTTTGGGCTTACTGCAACTTATAAGCAGGTTTATGATAAACTTCGGGAGTCGACGGATACTGCCATTTCTTATTTTGTTCCAAATTGTCCAGCATTTCGAGAGGCATATAAGAAAAATGAAGCTGCATTTTTAGAAAAGCCTATTCTTTTTGCAGGAGCTAGGGAAGTTCTTGAGAAGATTGTTGCTGGTGGAGGACGGAATTTTTTGGTCTCTCACCGCGATAATCAAGTTTTGGAAATTTTAGATAAAACAAAGATTGCTTCTCTTTTTACAGAAGTTGTTACTGCCAGTAATGGCTTTGCCAGAAAACCAGATCCAGCCAGTATGCTCTATTTAAAGAAAAAATACGCCCTTACAAATGCTCTTGTCATTGGTGATCGAAAGATTGATGTTCAAGCAGGTCAGGCAGCTGGTTTTGATACTGTTTTAGTAGATGGGTCAAAGTCTTTGATAGCAATCATAAATGAAGGTAAAATGAAATAA","9.50","3.43","21346","MKGMNYHDYIWDLGGTLLDNYGMSTKAFVATLADFGLTATYKQVYDKLRESTDTAISYFVPNCPAFREAYKKNEAAFLEKPILFAGAREVLEKIVAGGGRNFLVSHRDNQVLEILDKTKIASLFTEVVTASNGFARKPDPASMLYLKKKYALTNALVIGDRKIDVQAGQAAGFDTVLVDGSKSLIAIINEGKMK","1207604","","phosphoglycolate phosphatase","Cytoplasm","Matches in gapped BLAST to phosphoglycolate phosphatase/ hydrolase, haloacid dehalogenase-like family and to some conserved hypotheticals:residues 1-189 are 60% similar to phosphoglycolate phosphatase from S.pneumoniae (gi|15902758|) and residues 4-188 are 59% similar to conserved hypothetical protein from S.pyogenes (gi|15674781|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0622 (7e-68).","

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[10-181]T$	Hydrolase

InterPro
IPR006439
Family

HAD-superfamily hydrolase, subfamily IA, variant 1
TIGR01549	$\"[8-172]T$	HAD-SF-IA-v1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[79-178]T$	G3DSA:3.40.50.1000
SSF56784	$\"[5-180]T$	SSF56784

","BeTs to 6 clades of COG0546COG name: Predicted phosphatasesFunctional Class: RThe phylogenetic pattern of COG0546 is a-TkyQ-CEBRhuj--oL---Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 9-136 are 52% similar to a (PROTEOME COMPLETE YJCF YSBA) protein domain (PD415277) which is seen in Q9CH37_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 11:19:47 2002","Wed Feb 27 11:19:20 2002","Thu Oct 17 16:15:37 2002","Wed Feb 27 11:19:20 2002","","Wed Feb 27 11:19:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1168 is paralogously related (blast p-value < 1e-3) to SMu0588, a predicted hydrolase and SMu1138, a predicted conserved hypothetical protein;possible hydrolase.","Wed Feb 27 11:23:50 2002","","No significant hits to the NCBI PDB database.","SMU.1278c","","Residues 6 to 181 (E-value = 1.7e-14) place SMu1168 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Wed Feb 27 11:19:20 2002","24379697","","","","","","1","","","SMU.1278c","657" "SMu1169","1209821","1208595","1227","ATGGCAAGCAAAAAAAAGCCGATTGATAGTCGGGTGGATTATTCTCTTATTTTACCAGTTTTCTTTTTAGTTTTGATAGGACTTTTCTCTGTTTATACAGCGACAATTCACGACTATCCTAGTAAAATTATGGTCGTGATGGGACAACAGTTGATTTGGTTGATTATGGGAGCTGCTATTAGTTTTGTTGTCATGCTCTTTAGTACAGAATTCCTTTGGAAAATCACTCCTTATTTATATGGCTTAGGGTTAATTTTAATGATTTTTCCTTTGATCTTTTACAGTCCTGAATTAGTTGCTTCGACGGGTGCTAAAAACTGGGTTTCCATTGGTTCAGTGACCTTATTTCAGCCTTCGGAGTTTATGAAAATTTCCTATATCTTAATTTTAGCACGCTTAACGGTCACTTTTAAACAAAAGTATAAAGAAAAGAATTTGCAAGAAGATGGGAAACTTTTACTCTGGTTTGCATTGTTAACACTGCCTATTATGATTCTTTTAGCTTTGCAAAAAGATTTGGGAACTGCTATGGTTTTTATGGCTATTTTAGCTGGTCTGGTATTAATCGCAGGTATCTCTTGGCAGATTATTTTGCCAGTCGTCGGTGCTGTTGCCTTGATAGTTGCTCTTTTTATGGTTGTTTTTTTAATTCCTGGTGGTAAGGAATTTCTCTATCATCATATGGGAGTAGATACCTATCAAATTAATCGTCTCTCAGCTTGGCTAAATCCCTTTGATTATGCTGGTAGCATTGCTTACCAACAAACTCAAGGCATGATTTCGATTGGTAGTGGTGGCTTATTTGGAAAGGGCTTTAACATTGTTGAACTTCCTGTTCCTGTCCGTGAAAGTGATATGATTTTTACAGTCATTGCTGAGAATTTTGGCTTTATTGGCGGCAGTATTGTGTTAGCCCTCTATTTAATTCTTATTTATCGTATGCTGCGTGTCACTTTTGCGTCAAACAATCTGTTTTATACTTATATTTCAACTGGTTTTATTATGATGATTCTTTTCCATATTTTTGAGAACATTGGAGCAGCAGTTGGTATCTTACCTTTAACAGGTATTCCGCTTCCTTTTATTTCCCAAGGAGGAAGTTCCTTGATTTCCAATTTGATTGGTGTTGGATTGGTCTTGTCTATGTCTTATCAAAATAGTCTCAATCAGGAAAAAGCCACAGAACGCTATTTTGCTCATATCAAAAAGGAGAGTCTTACAAGTTAA","9.80","5.20","45300","MASKKKPIDSRVDYSLILPVFFLVLIGLFSVYTATIHDYPSKIMVVMGQQLIWLIMGAAISFVVMLFSTEFLWKITPYLYGLGLILMIFPLIFYSPELVASTGAKNWVSIGSVTLFQPSEFMKISYILILARLTVTFKQKYKEKNLQEDGKLLLWFALLTLPIMILLALQKDLGTAMVFMAILAGLVLIAGISWQIILPVVGAVALIVALFMVVFLIPGGKEFLYHHMGVDTYQINRLSAWLNPFDYAGSIAYQQTQGMISIGSGGLFGKGFNIVELPVPVRESDMIFTVIAENFGFIGGSIVLALYLILIYRMLRVTFASNNLFYTYISTGFIMMILFHIFENIGAAVGILPLTGIPLPFISQGGSSLISNLIGVGLVLSMSYQNSLNQEKATERYFAHIKKESLTS","1208610","For other 'rod' genes see SMu0017 (rodB).","cell division protein; shape-determining protein","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to rod shape determining protein: residues 5-393 are 62% similar to the protein in S.pneumoniae (gi15902756). Residues 9-384 are 53% similar to the protein from Lactococcus lactis (gi15672878).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0621 (1e-159).","

InterPro
IPR001182
Family

Cell cycle protein
PF01098	$\"[13-388]T$	FTSW_RODA_SPOVE
PS00428	$\"[344-368]T$	FTSW_RODA_SPOVE

","BeTs to 11 clades of COG0772COG name: Bacterial cell division membrane protein FtsW/MrdB/SpoVEFunctional Class: DThe phylogenetic pattern of COG0772 is -----QVcEBRHUJ--OLINXNumber of proteins in this genome belonging to this COG is 2","***** IPB001182 (Cell cycle proteins) with a combined E-value of 3.2e-40. IPB001182A 103-120 IPB001182B 252-273 IPB001182C 278-299 IPB001182D 343-368","Residues 1-47 are 51% similar to a (3'REGION GTFK) protein domain (PD244500) which is seen in Q00605_STRSL.Residues 16-381 are 53% similar to a (CELL DIVISION COMPLETE PROTEOME) protein domain (PD003242) which is seen in Q9CH43_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 17:50:05 2006","Thu Sep 7 17:50:05 2006","Thu Sep 7 17:48:46 2006","Wed Feb 27 11:28:55 2002","Wed Feb 27 11:28:55 2002","Thu Sep 7 17:50:05 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1169 is paralogously related (blast p-value < 1e-3) to SMu0650, a predicted cell division protein FtsW.","Wed Feb 27 11:31:08 2002","","No significant hits to the NCBI PDB database.","SMU.1279c","","Residues 13 to 388 (E-value = 2.6e-71) place SMu1169 in the FTSW_RODA_SPOVE family which is described as Cell cycle protein (PF01098)","Wed Feb 27 11:28:55 2002","24379698","","","","","","1","","","SMU.1279c","301" "SMu1170","1211146","1210028","1119","ATGTTTTATCGCTATACAGGAAATCAACAATTTGATTTACAAATTAATCGTCTTTGTTTCCCTTTTGAAGGTAACGAAAAAGTGGAAGAAGATCTCAAGCTAATTGTTCCTCAATTAAAAGATATCTCCTCTTGGAACAAGGTTTGGAAAGAGTTTGCTTTGATGCGAGAAGCCAAGGGAGATTATGCATTGGCAGCGTCTTATTTTTTTGGAGCCAGCTTTTATCTTCTAGAGGATGATACAGATAGAGAATTAATCCAAGAGCATCGTTTGCAAAATTTTTATCGTGCCTATGGAGATCTTGGCTTTGAACGACACGAAATCCCTTATGATAATACAAGTTTGCCAGCAGTCACTTTTATGCAACCTTCTGCTAAGAAAAATTTACTCATCTTTGGAGGTTATGACAGCAATCTGGAAGAACTCATTCTATGGTTTTCACCTTTAAGAAATAATGGTTATAATCTCATTATTTTTGATGGTCCGGGTCAAGGAAATATGCTTTTTAAAAAAGAGAAAAGTCATTTCATAATGAATTTTGAAAAGCCGGTGGCAGCTGTTTTAGATTATTTTTCTTTGGATAGGGTGGCAGCTTTGGGACTCTCCTGGGGAGGTTTCTTTGTCATGCGAGCAGCTGCTTTTGAAAAGAGAATTGAGAAGATTATTGCTTTAGACATTTTTTATCAAGGATTGGATGCTCTGACCATTGCTATGAACCCAGTTTTAGCTTTTATTTTTAAAACTTTAGTCAATTTTAAGTGTAAGACATGGATTGATGTTTTGCTTACGCATGCTATGACAAGAGATTTGGATTTAAATTGGAAAATAAAGCGAGGTTATCAATTGACTGGGACAAAAACACCTTATGATTTGATTCAAAATATTAAAAAACACAATATGAAGGGCTTGGGACCTCTGATTAATCAAGAAGTCCTCCTATTAGCTGGAGAAAAGGATCAATATGTGCCAGTTAAACGTCTTGGGCAAATCAAAAAAGAACTCAGCAATGCAGCAGAAATAAAAACGCATCTTTTTACGCAGGAAAGTGGTGGCGAACAACATTGTCAGGCTGGCAGTAATTTAGCTTTGCTGGCTATTAAAGACTTTTTGAAAATTTAA","7.60","1.56","42781","MFYRYTGNQQFDLQINRLCFPFEGNEKVEEDLKLIVPQLKDISSWNKVWKEFALMREAKGDYALAASYFFGASFYLLEDDTDRELIQEHRLQNFYRAYGDLGFERHEIPYDNTSLPAVTFMQPSAKKNLLIFGGYDSNLEELILWFSPLRNNGYNLIIFDGPGQGNMLFKKEKSHFIMNFEKPVAAVLDYFSLDRVAALGLSWGGFFVMRAAAFEKRIEKIIALDIFYQGLDALTIAMNPVLAFIFKTLVNFKCKTWIDVLLTHAMTRDLDLNWKIKRGYQLTGTKTPYDLIQNIKKHNMKGLGPLINQEVLLLAGEKDQYVPVKRLGQIKKELSNAAEIKTHLFTQESGGEQHCQAGSNLALLAIKDFLKI","1210043","","conserved hypothetical protein (possible alpha/beta superfamily hydrolase)","Cytoplasm, Extracellular","Matches in gapped BLAST to different kinds of proteins: residues 1-370 are 42% similar to the alpha/beta superfamily hydrolase in Clostridium acetobutylicum (gi|15896673|).Residues 41-359 are 26% similar to hypothetical protein from S.hygroscopicus (gi|7481878|).SMu1170 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000073
Domain

Alpha/beta hydrolase fold-1
PF00561	$\"[154-231]T$	Abhydrolase_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[129-371]T$	G3DSA:3.40.50.1820
PTHR10992	$\"[118-342]T$	PTHR10992
SSF53474	$\"[104-371]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 65-218 are 34% similar to a (PROTEOME FOR COMPLETE VC2276) protein domain (PD140883) which is seen in Q54287_STRHY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 11:39:44 2002","Thu Oct 17 16:16:48 2002","Thu Oct 17 16:16:48 2002","Wed Feb 27 11:38:56 2002","","Wed Feb 27 11:38:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1170 is paralogously related (blast p-value < 1e-3) to SMu0670, a predicted conserved hypothetical protein; possible alpha/beta superfamily hydrolase.","Wed Feb 27 11:39:44 2002","","No significant hits to the NCBI PDB database.","SMU.1280c","","No significant hits to the Pfam 11.0 database","Wed Feb 27 11:38:56 2002","24379699","","","","","","1","","","SMU.1280c","" "SMu1171","1211285","1211851","567","ATGGCACAAGATATCCGCGTTTTTAAGAGTAAACGCGACATTGAAACAGCGGTCATCCAACTCATTTTAGAAGAAGATTTTAGTAAATTAACTATCCAGCAAATTTGTCAGAAAGCGCTTGTCAGCCGTTCAACATTCTACAGTCACTACTTAGACAAATATGATGTTGTGGAGCAATTAGTAGCCAAGACAATTACCCAATTAGAAACCATATTTTCTCAAAAATACCAGTCACAGGTTAGCCCAGAAAACTTAAAAGATTATCTAGCAGATATTTATCAATTTTATCAAGAAAATGCCCGCTTACTAAAAGCCCTTCTCAAAACACCATTAACAGGAACGGGTAATTTCGAAGAGGCCTTCAGTAAACTTTGTCAAACCTATATTAACCATCTGGCAGCCACCACCAAAGATAATGACCATTTACCACCACAACTCTTAGCAGAAATTTTTACGGCAAATGTGGTCACTCTTATGAAATGGATTATTGAGCATGGTCCTTCAGAAAATGTCACTCATTTTGCGGATTGGTTGCATGATCTTTTTCTACAATACCTGCAAGAATGA","5.30","-5.65","21837","MAQDIRVFKSKRDIETAVIQLILEEDFSKLTIQQICQKALVSRSTFYSHYLDKYDVVEQLVAKTITQLETIFSQKYQSQVSPENLKDYLADIYQFYQENARLLKALLKTPLTGTGNFEEAFSKLCQTYINHLAATTKDNDHLPPQLLAEIFTANVVTLMKWIIEHGPSENVTHFADWLHDLFLQYLQE","1211860","For other 'psa' genes see SMu1001 (psaA); SMu1067 (psaB);SMu1068 (psaA); SMu1069 (psaR); SMu1231 (psaA); SMu1752 (psaB) ; SMu1750 (psaR) and SMu1751 (psaA). ","transcriptional regulator, AcrR family","Cytoplasm","Matches in gapped BLAST to transcriptional regulators, AcrR family : residues 17-167 are 27% similar to the previously published protein PsaR in S.mutans (gi|15625443|). Residues 4-180 are 26% similar to transcriptional regulators, AcrR family from Clostridium acetobutylicum (gi|15893494|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2135 (4e-12).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[20-60]T$	TetR_N
PS50977	$\"[8-68]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[9-79]T$	Homeodomain_like

","BeTs to 3 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","No significant hits to the Blocks database.","Residues 2-106 are 25% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD106875) which is seen in Q9CDI1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:43:53 2002","Thu Oct 24 14:43:53 2002","Thu Oct 17 16:17:17 2002","Wed Feb 27 13:12:37 2002","","Fri Jan 4 12:52:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1171 is paralogously related (blast p-value < 1e-3) to SMu1139, SMu0398, SMu1069, SMu1750, SMu1936, SMu0214, SMu0466, and SMu1440, all predicted transcription regulators.","Wed Feb 27 13:15:12 2002","","No significant hits to the NCBI PDB database.","SMU.1282","","No significant hits to the Pfam 11.0 database","Fri Jan 4 12:52:07 2002","24379700","","","","","","1","","","SMU.1282","" "SMu1172","1212772","1212113","660","ATGAAGAGAGTACTGGTATTAGGAGCAACTGGCAGGACAGGAAATTTTGTCATAAAAGAATTGTCCAAATACAAATCTATTCAGTTAATTGCTGGCTTAAGAAGTCAAAAAGATAAAGAAAGACTGCCCAAGATAAATGCAGCCATAGAGACAGTAGTGATTGATATTGCTGACGTCTGCAGTTTACGTAAGGCTCTTACTGACAGTGACATAGTTGTTCAAGCCATTCGTTTACGGGGAGATATATCAGAGAATGCTTTAATTCAACTGGATCAACGGATCCATCAGGCCTTTAATCCATCAAGGAAAACTCATCTTGTTACGGTTGGAGGCGCAGGGGCTTTAAAATTAGAAGCAAATCAGCGTTTTTGGGAGAATGAATATTTTCCAAGACAAACTCTGCCTAGAGGAATTGCTCATGCTAGGCTTAGAGACTATTTGGAAAAGTCATTTTTTAACCACACTTGGACCTATTTGATTCCTCCGCCAGTTTATGTTGCTGAAGGGGCAAGAACTGGCAGTTATAACCGCTACAGTTCGGCTCAAAAAGAAGACTTTTTTCTCAGTAAATCCATTTCTTATGCAGACTTTGCTTTGGCGATAGGAAATGCTGTAATGGAAGAGTGGCAGGGTGTTTACTTGATTGCAGAAAAGGAATGA","10.20","6.92","24732","MKRVLVLGATGRTGNFVIKELSKYKSIQLIAGLRSQKDKERLPKINAAIETVVIDIADVCSLRKALTDSDIVVQAIRLRGDISENALIQLDQRIHQAFNPSRKTHLVTVGGAGALKLEANQRFWENEYFPRQTLPRGIAHARLRDYLEKSFFNHTWTYLIPPPVYVAEGARTGSYNRYSSAQKEDFFLSKSISYADFALAIGNAVMEEWQGVYLIAEKE","1212128","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to hypotheticals and conserved hypotheticals:residues 3-201 are 25% similar to gi|7475515| from B.subtilis.Residues 3-206 are 25% similar to gi|15792862| from Campylobacter jejuni.SMu1172 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005097
Family

Saccharopine dehydrogenase
PF03435	$\"[4-76]T$	Saccharop_dh

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[3-208]T$	G3DSA:3.40.50.720
PTHR15020	$\"[1-201]T$	PTHR15020
SSF51735	$\"[1-165]T$	SSF51735

InterPro
IPR005829
Family

Sugar transporter superfamily
PS00216	$\"[67-83]T$	SUGAR_TRANSPORT_1

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[7-391]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[17-361]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[2-386]T$	PTHR10074
PTHR10074:SF29	$\"[2-386]T$	PTHR10074:SF29
SSF103473	$\"[1-386]T$	SSF103473

","BeTs to 13 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","***** IPB002897 (Monocarboxylate transporter) with a combined E-value of 4.2e-08. IPB002897B 58-112 IPB002897D 217-269 IPB002897E 323-374 IPB002897B 302-356***** IPB003662 (General substrate transporters) with a combined E-value of 5.9e-07. IPB003662A 103-135***** IPB000849 (GlpT family of transporters) with a combined E-value of 1.7e-06. IPB000849B 48-88","Residues 46-206 are 26% similar to a (PROTEOME COMPLETE NITRATE TRANSPORTER) protein domain (PD189326) which is seen in O66589_AQUAE.Residues 42-143 are 29% similar to a (GLUCOSE CARRIER FACILITATED SOLUTE) protein domain (PD278178) which is seen in O95528_HUMAN.Residues 14-157 are 27% similar to a (PROTEOME MFS COMPLETE TRANSPORTER) protein domain (PD275577) which is seen in Q9HTS2_PSEAE.Residues 91-166 are 26% similar to a (COMPLETE TRANSMEMBRANE PROTEOME TRANSPORT) protein domain (PD000036) which is seen in YWFA_BACSU.Residues 13-86 are 33% similar to a (TRANSMEMBRANE TRANSPORT TRANSPORTER COMPLETE PROTEOME) protein domain (PD000082) which is seen in Q9KD16_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 14:28:05 2002","Wed Oct 23 12:26:53 2002","Thu Oct 17 16:18:07 2002","Wed Feb 27 13:26:19 2002","Wed Feb 27 13:26:19 2002","Wed Feb 27 13:26:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1173 is paralogously related (blast p-value < 1e-3) to SMu1465, SMu1914, SMu0119, SMu1460, SMu0677, SMu0130, all permease-related proteins and SMu1287, a predicted conserved hypothetical protein.","Wed Feb 27 14:37:08 2002","","No significant hits to the NCBI PDB database.","SMU.1286c","","No significant hits to the Pfam 11.0 database","Wed Feb 27 13:26:19 2002","24379702","","","","","","1","","","SMU.1286c","" "SMu1174","1214103","1214453","351","ATGGAAAAAAGAAACGAAGATTATTCGGCATTATTAGATGTCAAACTCCTAAAAAAATTAGTTGTCGGTATCGGTGAGGTTTCTAAAATCACTGGTATCCCTATTCGAAAAATCCGTTATTGGGAAGAAAAAGGAATCATCCACTCTCAAAACAATAAAGGGGGAACAACCAGAAGATATGATTATATGAATATCAAAAAAATACTTTTAATTCAAGAAATGCTAGAAGAAGGTTTCACCTTAGAAGCTTCTGTTAAAAAAGTTGAAAAACGTCTGTCTACTTTGAATGATATGTTCAAAAATTTATCCAATCATTTGGAAGACAGGCCATTGAATTCTGAAGACAAATAA","10.10","4.48","13520","MEKRNEDYSALLDVKLLKKLVVGIGEVSKITGIPIRKIRYWEEKGIIHSQNNKGGTTRRYDYMNIKKILLIQEMLEEGFTLEASVKKVEKRLSTLNDMFKNLSNHLEDRPLNSEDK","1214462","","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Residues 24-91 are 36% similar to gi|15614057| from B.halodurans.Residues 24-97 are 32% similar to gi|16078396| from B.subtilisThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1764 (1e-05).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PR00040	$\"[23-34]T$ $\"[34-47]T$ $\"[58-78]T$	HTHMERR
PF00376	$\"[23-60]T$	MerR
SM00422	$\"[24-91]T$	HTH_MERR
PS50937	$\"[21-91]T$	HTH_MERR_2

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[21-109]T$	Putativ_DNA_bind

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[22-82]T$	G3DSA:1.10.1660.10

","BeTs to 4 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 8.8e-16. IPB000551A 24-45 IPB000551B 47-88","Residues 24-91 are 36% similar to a (PROTEOME DNA-BINDING REGULATION) protein domain (PD167972) which is seen in Q9KCS5_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 14:43:04 2002","Wed Feb 27 14:42:36 2002","Thu Oct 17 16:19:06 2002","Wed Feb 27 14:42:36 2002","Wed Feb 27 14:42:36 2002","Wed Feb 27 14:42:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1174 is paralogously related (blast p-value < 1e-3) to SMu0663, SMu0328, SMu0477, and SMu1918 all predicted transcriptional regulators.","Wed Feb 27 14:42:36 2002","","No significant hits to the NCBI PDB database.","SMU.1287","","No significant hits to the Pfam 11.0 database","Wed Feb 27 14:42:36 2002","24379703","","","","","","1","","","SMU.1287","" "SMu1175","1214979","1214632","348","ATGAATCCATTAATCCAAAGTTTGACCGAAAGTCAACTCCGTACAGACATTCCTAACTTCCGCCCTGGTGACACTGTTCGTGTTCACGCAAAGGTTGTTGAAGGAAACCGTGAACGTGTCCAAATTTTTGAAGGTGTTGTCATTTCCCGTAAAGGTCAAGGTATCTCAGAAATGTATACTGTTCGTAAGATTTCAAGCGGTGTTGGTGTTGAACGTACTTTTCCAACTCATACACCACGTGTTGAAAAAATCGAAGTGACTCGTCATGGTAAAGTTCGTCGCGCTAAATTGTATTATCTTCGTGCATTGCAAGGTAAAGCTGCACGTATCAAGGAAGTCCGTCAATAG","11.60","12.71","13136","MNPLIQSLTESQLRTDIPNFRPGDTVRVHAKVVEGNRERVQIFEGVVISRKGQGISEMYTVRKISSGVGVERTFPTHTPRVEKIEVTRHGKVRRAKLYYLRALQGKAARIKEVRQ","1214647","For other 'rpl' genes see SMu0639 (rplT); SMu0771 (rplU); SMu0152 (rplM); SMu1941 (rplI); SMu0869 (rplJ); SMu0872 (rpl); SMu1480 (rplA) and SMu1481 (rplK).From Genbank:[gi:3122696]This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.","50S ribosomal protein L19","Cytoplasm, Extracellular","Several matches in gapped BLAST to 50S ribosomal protein L19: residues 1-115 are 90% similar to the protein in S.pyogenes (gi|15674780|) and are 88% similar to the protein from S.pneumoniae (gi|15901153|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0544 (6e-55).","

InterPro
IPR001857
Family

Ribosomal protein L19
PD002979	$\"[23-101]T$	Ribosomal_L19
PR00061	$\"[4-33]T$ $\"[34-63]T$ $\"[88-113]T$	RIBOSOMALL19
PTHR15680	$\"[5-115]T$	Ribosomal_L19
PF01245	$\"[2-114]T$	Ribosomal_L19
TIGR01024	$\"[2-114]T$	rplS_bact
PS01015	$\"[86-101]T$	RIBOSOMAL_L19

","BeTs to 12 clades of COG0335COG name: Ribosomal protein L19Functional Class: JThe phylogenetic pattern of COG0335 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001857 (Ribosomal protein L19) with a combined E-value of 1e-59. IPB001857A 17-63 IPB001857B 74-112","Residues 4-114 are 90% similar to a (RIBOSOMAL 50S CHLOROPLAST PROTEOME) protein domain (PD002979) which is seen in RL19_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:20:02 2002","Wed Feb 27 14:46:54 2002","Thu Oct 17 16:20:02 2002","Wed Feb 27 14:46:54 2002","Wed Feb 27 14:46:54 2002","Wed Feb 27 14:46:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1175 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 14:46:54 2002","","No significant hits to the NCBI PDB database.","SMU.1288c","","Residues 2 to 114 (E-value = 3.9e-65) place SMu1175 in the Ribosomal_L19 family which is described as Ribosomal protein L19 (PF01245)","Wed Feb 27 14:46:54 2002","","","","","","","1","","","SMU.1288c","781" "SMu1176","1216388","1215168","1221","ATGATTGAAAAAAAGATTAAAGAAGCAAATGAACTGTCTTACTCTATTTTGCTTTACTTAGCTTTTATGGGATTGCTAATTGGTGCCCTTGTAGGTCTTGTTGATACTATCTTTGGACGAGTTTTAATCTATTTGAGTGCTGTTAGAGATGCTAATCCTTGGTACTGGCTTCCCTTTTTGGGAATCGCTGGTTTAATAATTGTTTATTTATATCAAAAGTGGGGTGCTAAAAGCAGTAAGGGGATGGGTTTAATATTTCAAGTAGGTTTTGAAGAGGAAGACCATATCCCTAAACGCCTCATTCCCATGGTTATTGTCACAACATGGTTGACTCATCTTTGTGGCGGCAGCGCTGGCCGTGAAGGTGTCGCTGTCCAACTAGGTGCGACAGTTTCTCACTGGTTTAGCCGATTATTCCATTTTCCCAATAAATCGCGTATTTTTCTGCTTTCAGGAATGGCTGCAGGTTTTGCAGGTTTGTATCAGACGCCCATGGCAGCTATACTATTTGCTTTAGAAGTATTAGTTCTTGGTAATCTAGGACTTTCTGCTTTGGTTCCAATGACCATTGCTTCTTTTACGGCTAGTTTGACCTCTCATAGTCTTGGTTTAGAAAAATTTGCACATACCCTGTCAAGGACAATTTCTTTGACACCGACTGTTTTTATTCAGTTGCTTATTTTAGGACTTATCTTTGGTTTAGCAGGCAATTTATTTGCTTTTTTATTAGCTTGGTGCAAGCAAGTGCAAGCACGCCTGCTTCCTAATCTTTATAGACGTATTTTTATTGTCGGCTTGCTGCTTAGTTTACTTTTTCTAGTCCTTTATCAAGGACGTTATTCTGGTTTGGGGACTAATCTGATTTCTGCTAGCTTTTCTGATGGGAAAATTTATGTCTATGATTGGCTACTAAAGCTTTTTCTAACAGTTATAACTCTGGCAGCAGGTTTTCAAGGTGGAGAAGTGACGCCTTTATTTGCTATCGGTTCTTCTTTGGGCGTTGTTTTAGCAGGCATTTTTCATCTGCCTTTAGAATTTGTGGCAGCTCTGGGCTATATTTCTGTCTTTGGCAGTGCAACTAATACCTTCTTAGCTCCAATTTTAATTGGTGGTGAAGTCTTTGGTTATCAGAATTTACCAGCTTATTTTATCGCGGTGACCTTTGCTTATGTTGTTAATCGTAAGCAGTCTATTTACTCGCTTCAAAAAATTAGAGATTAG","10.30","10.58","44421","MIEKKIKEANELSYSILLYLAFMGLLIGALVGLVDTIFGRVLIYLSAVRDANPWYWLPFLGIAGLIIVYLYQKWGAKSSKGMGLIFQVGFEEEDHIPKRLIPMVIVTTWLTHLCGGSAGREGVAVQLGATVSHWFSRLFHFPNKSRIFLLSGMAAGFAGLYQTPMAAILFALEVLVLGNLGLSALVPMTIASFTASLTSHSLGLEKFAHTLSRTISLTPTVFIQLLILGLIFGLAGNLFAFLLAWCKQVQARLLPNLYRRIFIVGLLLSLLFLVLYQGRYSGLGTNLISASFSDGKIYVYDWLLKLFLTVITLAAGFQGGEVTPLFAIGSSLGVVLAGIFHLPLEFVAALGYISVFGSATNTFLAPILIGGEVFGYQNLPAYFIAVTFAYVVNRKQSIYSLQKIRD","1215183","","voltage-gated chloride channel family","Membrane, Cytoplasm","Matches in gapped BLAST to hypotheticals and some different kinds of proteins:residues 4-390 are 56% similar to TM protein from S.thermophilus (gi13346817).Residues 4-404 are 51% similar to a transposase from S.pyogenes.Residues 12-400 are 47% similar to a hypothetical from Lactococcus lactis (gi15673080). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0541 (1e-116).","

InterPro
IPR001807
Family

Chloride channel, voltage gated
PR00762	$\"[154-173]T$ $\"[317-337]T$ $\"[345-361]T$	CLCHANNEL
PTHR11689	$\"[16-342]T$	Cl-channel_volt

InterPro
IPR014743
Domain

Chloride channel, core
PF00654	$\"[56-397]T$	Voltage_CLC

noIPR
unintegrated

unintegrated
G3DSA:1.10.3080.10	$\"[2-405]T$	G3DSA:1.10.3080.10
PTHR11689:SF14	$\"[16-342]T$	PTHR11689:SF14
SSF81340	$\"[11-405]T$	SSF81340

","BeTs to 7 clades of COG0038COG name: Permease, putative chloride channelFunctional Class: PThe phylogenetic pattern of COG0038 is am-kyQ-CE-r----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 282-400 are 58% similar to a (CHANNEL CHLORIDE VOLTAGE-GATED TRANSMEMBRANE IONIC CBS) protein domain (PD001079) which is seen in Q9CGJ8_LACLA.Residues 161-221 are 47% similar to a (PROTEOME COMPLETE YLAD TRANSPOSASE) protein domain (PD213056) which is seen in Q9CGJ8_LACLA.Residues 45-221 are 28% similar to a (OF SECTION COMPLETE BASES) protein domain (PD039356) which is seen in P77195_ECOLI.Residues 55-158 are 50% similar to a (CHANNEL CHLORIDE VOLTAGE-GATED TRANSMEMBRANE TRANSPORT) protein domain (PD001036) which is seen in Q9CGJ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 15:00:45 2002","Thu Feb 8 14:21:18 2007","Thu Sep 7 17:42:32 2006","Wed Feb 27 14:59:01 2002","","Wed Feb 27 14:59:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1176 is paralogously related (blast p-value < 1e-3) to SMu1177, a predicted conserved hypothetical protein.","Wed Feb 27 15:00:45 2002","","No significant hits to the NCBI PDB database.","SMU.1289c","","Residues 56 to 397 (E-value = 1.9e-13) place SMu1176 in the Voltage_CLC family which is described as Voltage gated chloride channel (PF00654)","Wed Feb 27 14:59:01 2002","24379705","","","","","","1","","","SMU.1289c","300" "SMu1177","1217694","1216474","1221","ATGGGGATTAAGATCAAGTCTTTTCTTGATTTAAAGAAAAACAGTCATCTGTTACTCATCTCGGGTGCAGCTATTTTAGTTGGTTTGTTGGTTGGCATCGTTGATATGATTTTTGGAATTGTCTTAAATACTCTGACTGCTTTTCGAGAAACGCATTTTTTATATTTGATTCCTTTTCTTTTTCTAGCAGGTCTTTTGATTGTTTTTATATATGATCATTTTGGCGGTAAAAGTATCAAAGGAATGAGTTTGGTTTTTGATGTTGCTGATGAAAGAGAAGTGACTATTCCTAAAAGATTGGTTCCATTAGCTATTTTTTCCACTTGGTTAACTCATCTTTTTGGTGGCAGCGCTGGTCGAGAAGGAGTGGCTATTCAGGTAGGAGCAGCTTTGTCTCATGCGTTCTCACCTGTTTTTAAATTTGAAGAGTCTTCTAGAAGTTTTTTGATTATTGGAATCGCTGCTGGCTTTGCAGGTTTATTTCAAACGCCCATGGCAGCCATATTATTTGCCCTTGAGGTTCTTGTTATTGGCCGATTGGAATTATCAACCTTATTACCCACCAGCCTAGCTGCTTATACTGCCAGCTATACCTCTCAATTATTGGGGTTAAAAAATTTTACCCATCTTATTAAAGTTCACATGACGTTAAATCCTGTCTTATTTGTGAAATTTGCTTTATTAGGCATTATCTTTGGTTTAGTTGGAACATCATTTGCTTACTTACTGAGAAGAACAAAATTAAGTTTAATATTACGCTTTAAAAGACCCTATCAACGTATTATGATCGTAGGGCTTTTACTAAGTGTTTTGTTTACTGCTGCTGGTATGGGGCGTTACTCAGGGCTGAGTACTGATTTGGTTACTGCTAGTTTTGCTAAAGGAACAGTCTATCCTTTTGATTGGCTGTTTAAATTAATTCTAACAGTATTAACCTTATCAGCAGGTTATCAAGGCGGTGAGGTGATGCCTATGTTTACCATTGGTGCAACACTTGGTGCGGTATTAGCCCCCCTATTTCATTTACCAATAGCTTTTGTTGCAGCTTTGGGTTATGCTAGTGTATTTGGCAGTGGAACCAGTACCTTTTTAGCACCAATTTTTATCGGTGGTGAAATTTTTGGCTTTGAAAACATTCCTTACTTTTTTATTGTGGTTTGTTTTGCCAGCATTGTTAAAAAACAAATCAGTGTTTATGGTGCACAAAAGGTTACTGCTTAA","10.50","13.87","43947","MGIKIKSFLDLKKNSHLLLISGAAILVGLLVGIVDMIFGIVLNTLTAFRETHFLYLIPFLFLAGLLIVFIYDHFGGKSIKGMSLVFDVADEREVTIPKRLVPLAIFSTWLTHLFGGSAGREGVAIQVGAALSHAFSPVFKFEESSRSFLIIGIAAGFAGLFQTPMAAILFALEVLVIGRLELSTLLPTSLAAYTASYTSQLLGLKNFTHLIKVHMTLNPVLFVKFALLGIIFGLVGTSFAYLLRRTKLSLILRFKRPYQRIMIVGLLLSVLFTAAGMGRYSGLSTDLVTASFAKGTVYPFDWLFKLILTVLTLSAGYQGGEVMPMFTIGATLGAVLAPLFHLPIAFVAALGYASVFGSGTSTFLAPIFIGGEIFGFENIPYFFIVVCFASIVKKQISVYGAQKVTA","1216489","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to hypotheticals and some different kinds of proteins:residues 3-389 are 54% similar to TM protein from S.thermophilus (gi|13346817|).Residues 5-404 are 52% similar to a transposase from S.pyogenes.Residues 24-404 are 48% similar to ahypothetical from Lactococcus lactis (gi|15673080|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0541 (1e-122).","

InterPro
IPR001807
Family

Chloride channel, voltage gated
PR00762	$\"[154-173]T$ $\"[317-337]T$ $\"[345-361]T$	CLCHANNEL
PTHR11689	$\"[24-335]T$	Cl-channel_volt

InterPro
IPR014743
Domain

Chloride channel, core
PF00654	$\"[55-397]T$	Voltage_CLC

noIPR
unintegrated

unintegrated
G3DSA:1.10.3080.10	$\"[2-398]T$	G3DSA:1.10.3080.10
PTHR11689:SF14	$\"[24-335]T$	PTHR11689:SF14
SSF81340	$\"[3-402]T$	SSF81340

","BeTs to 7 clades of COG0038COG name: Permease, putative chloride channelFunctional Class: PThe phylogenetic pattern of COG0038 is am-kyQ-CE-r----------Number of proteins in this genome belonging to this COG is 2","***** PR00762 (Chloride channel signature) with a combined E-value of 1.1e-06. PR00762C 154-173 PR00762D 317-337","Residues 282-404 are 49% similar to a (CHANNEL CHLORIDE VOLTAGE-GATED TRANSMEMBRANE IONIC CBS) protein domain (PD001079) which is seen in Q9CGJ8_LACLA.Residues 161-240 are 42% similar to a (PROTEOME COMPLETE YLAD TRANSPOSASE) protein domain (PD213056) which is seen in Q9CGJ8_LACLA.Residues 115-259 are 25% similar to a (OF SECTION COMPLETE BASES) protein domain (PD039356) which is seen in P77195_ECOLI.Residues 55-158 are 57% similar to a (CHANNEL CHLORIDE VOLTAGE-GATED TRANSMEMBRANE TRANSPORT) protein domain (PD001036) which is seen in Q9CGJ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 21 14:36:14 2002","Wed Feb 27 15:03:09 2002","Wed Feb 27 15:03:09 2002","Wed Feb 27 15:03:09 2002","Wed Feb 27 15:03:09 2002","Wed Feb 27 15:03:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1177 is paralogously related (blast p-value < 1e-3) to SMu1176, a predicted conserved hypothetical protein.","Thu Mar 21 14:36:14 2002","","No significant hits to the NCBI PDB database.","SMU.1290c","","Residues 55 to 397 (E-value = 2.3e-13) place SMu1177 in the Voltage_CLC family which is described as Voltage gated chloride channel (PF00654)","Wed Feb 27 15:03:09 2002","24379706","","","","","","1","","","SMU.1290c","" "SMu1178","1217956","1217684","273","ATGGACTTACAAGAAATTAGGTCACAAATTGATGATGTGGATAAAGAATTGGTGCAGTGTTTAGAAAGACGAATGACTTTGGTTAGTCAGGTTGCTGATTATAAAAAAGCAACTGGTAAATCGGTCTTAGATACAAAGCGTGAACAAATCTTGTTGGAAAAAGTAGCAGGCCTTGTTGTCAATGATACATATCGCTCCACCATTTCAGCTATCTTTGCTGATATTTTAAAACATTCTAGGAATTATCAAAGGAGAGCATTAGATGGGGATTAA","7.30","0.18","10310","MDLQEIRSQIDDVDKELVQCLERRMTLVSQVADYKKATGKSVLDTKREQILLEKVAGLVVNDTYRSTISAIFADILKHSRNYQRRALDGD","1217699","For other 'phe' genes see SMu0713 (pheA); SMu1788 (pheT); SMu1367 (pheT); SMu1372 (pheT) and SMu1374 (pheS).","chorismate mutase","Cytoplasm","Several matches in gapped BLAST to chorismate mutase: residues 1-88 are 54% similar to the enzyme in S.thermophilus (gi13346816).Residues 1-83 are 54% similar to the protein from S.pneumoniae (gi15901156).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0540 (1e-14).","

InterPro
IPR002701
Domain

Chorismate mutase
PF01817	$\"[7-86]T$	CM_2
PS51168	$\"[1-87]T$	CHORISMATE_MUT_2
SSF48600	$\"[1-89]T$	Chorismate_mut

InterPro
IPR008239
Family

Chorismate mutase of the AroQ class, prokaryotic type
PIRSF001501	$\"[1-90]T$	Chor_mut_AroQ_pr

InterPro
IPR011279
Domain

Chorismate mutase, Gram-positive
TIGR01805	$\"[3-83]T$	CM_mono_grmpos

noIPR
unintegrated

unintegrated
G3DSA:1.20.59.10	$\"[3-55]T$	G3DSA:1.20.59.10

","BeTs to 6 clades of COG1605COG name: Chorismate mutaseFunctional Class: EThe phylogenetic pattern of COG1605 is amt--qv-EbrHuj-------Number of proteins in this genome belonging to this COG is 2","***** IPB002701 (Chorismate mutase) with a combined E-value of 2.7e-10. IPB002701 3-35","Residues 3-84 are 45% similar to a (CHORISMATE PROTEOME COMPLETE MUTASE) protein domain (PD005194) which is seen in Q9CDM2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 08:43:13 2006","Wed Feb 27 15:07:20 2002","Thu Aug 31 08:43:13 2006","Wed Feb 27 15:07:20 2002","Wed Feb 27 15:07:20 2002","Wed Feb 27 15:07:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1178 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 15:10:45 2002","","No significant hits to the NCBI PDB database.","SMU.1291c","","No significant hits to the Pfam 11.0 database","Wed Feb 27 15:07:20 2002","24379707","","","Mattei P, Kast P, Hilvert D.Bacillus subtilis chorismate mutase is partially diffusion- controlled.Eur J Biochem. 1999 Apr;261(1):25-32.PMID: 10103029 Kast P, Asif-Ullah M, Jiang N, Hilvert D.Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis.Proc Natl Acad Sci U S A. 1996 May 14;93(10):5043-8.PMID: 8643526 ","","Wed Feb 27 15:10:45 2002","1","","","SMU.1291c","1010" "SMu1179","1218679","1218002","678","ATGAAGAGAATACATGTAAGATATAAGCAAATTAGACGCTTTTTTCTTTTACTGGGACTTGTGATTATTGCTGCCTATGTAGCCTTTGTCCTCTATCGCTATTGGGATCATTGGCTTCTTTTAAGTAATCCCCAAAAAGCGATAGAGAATTTTGAGCAGCAATTTCGTTCGGAAAATCTCTTTAATTTTCTCGTTTTAACTGTTTTAACGAGTTTAACAGCCGCCATTCCTTTTTTATCTAGTTCTGTTTTATCTGTTTTTAATGGGGTAGTTTTTGGACCGTGGATTGGCGTTTTGATGAATACCATAGGGAATATCTTAGGACATTTTTTTCTGATTCAGATGATGTCACGTGTTGATTTGACTGAAAGAGACAGTAAATTTAATCATCATCTTGAAAGACTCTCTCAAATAAAAAATCCTTATCTTGCTCTGACATTGGGCTATATGATACCTTTTATTCCCTCTTTTTTAGTTGATTATATGGTTCTGGATACAAAAATACCTTGGCACCGTTGGCTGCCTTGCCTCACCTTAGGTGTTATACCAACCAGTATCCTTTATGCATTTGGAGGCCACGCCATTATAGCTGGAAATATGAAACAATTAATACTGATTGTTTTACTTGCATTGATATTACTGGCTATTTATAAACGATTTGAAAAAAAGAAAGGCTAG","10.80","12.62","26032","MKRIHVRYKQIRRFFLLLGLVIIAAYVAFVLYRYWDHWLLLSNPQKAIENFEQQFRSENLFNFLVLTVLTSLTAAIPFLSSSVLSVFNGVVFGPWIGVLMNTIGNILGHFFLIQMMSRVDLTERDSKFNHHLERLSQIKNPYLALTLGYMIPFIPSFLVDYMVLDTKIPWHRWLPCLTLGVIPTSILYAFGGHAIIAGNMKQLILIVLLALILLAIYKRFEKKKG","1218017","","conserved hypothetical protein","Membrane, Cytoplasm","Matches very weakly in gapped BLAST to conserved hypothetical proteins: residues 11-195 are 20% similar to the protein in Clostridium acetobutylicum (gi|15895963|).Residues 77-192 are 26% similar to the protein from B.subtilis (gi|16079625|). SMu1179 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR015414
Domain

SNARE associated Golgi protein
PF09335	$\"[79-194]T$	SNARE_assoc

noIPR
unintegrated

unintegrated
PTHR12677	$\"[3-223]T$	PTHR12677

","BeTs to 3 clades of COG0398COG name: Uncharacterized ACR, YdjX/UPF0043 familyFunctional Class: SThe phylogenetic pattern of COG0398 is ----y--cEBR----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 15:18:04 2002","Wed Feb 27 15:17:22 2002","Wed Feb 27 15:17:22 2002","Wed Feb 27 15:17:22 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1179 is paralogously related (blast p-value < 1e-3) to SMu1096, and SMu0779 both predicted hypothetical proteins.","Wed Feb 27 15:18:04 2002","","No significant hits to the NCBI PDB database.","SMU.1292c","","No significant hits to the Pfam 11.0 database","Wed Feb 27 15:17:22 2002","24379708","","","","","","1","","","SMU.1292c","" "SMu1180","1220483","1219101","1383","TTGAAGAATAGAGATTATGCTTTCGGTTTTCACGATGATGTCAAGCCTCTTTACTCAACAGGTAAGGGGTTGACAGAAGAAGTTGTTAGAGATATTTCCGAAATCAAAAACGAACCTCAGTGGATGCTGGATTATCGTTTACGTTGTTTGGAACTTTTTTACAAATTGCCCATGCCTAAATGGGGTCCAGATTTGTCTGGTATCAATTTTAATGATGTTATTTATTATCAGAAACTTAGCGGTCAGCCTTCTAGAAGCTGGGATGATGTGCCTGACGATATCAAAAAAACGTTTGAGCGTTTAGGTATTCCCAATGCAGAGCGTCAGTTTTTATCTGGTGCAGTAGCCCAATATGAGTCAGAAGTGGTTTACCACAATATGAAAGAAGAATTTGAAAAAATGGGCATTATTTTTACTGATACGGATACGGCCTTGCAGGAGTATCCTGACCTTGTGAAAAAGTATTTTGCGTCAGTTGTTTCGCCTGCTGAACATAAATTTGCAGCTTTAAATGGCGCTGTCTGGTCAGGCGGAACGTTTATTTATGTTCCCAAAGGGGTTCAATGTCAGATTCCTGTGCAGACTTATTTTCGTATTAATGGAGAGAATGCTGGTCAATTTGAACGTTCGCTCATGATCATTGAAGAAGGAGCTTCTATTCAATATATTGAAGGTTGTACGGCTCCAACTTACTCAACCAATAGTTTGCATGCAGCGACTGTTGAAATTATTGTCAAACGTGATGCTTCTTTTCGTTACACCACTATTCAAAATTGGTCTGATAATGTCTATAATCTTGTTACTGAAAGAGGTACGGTAGAAGAAAACGGAACCTTAGAATGGATTGATGGTAACTTAGGCAGCAAAGTTAATATGAAATATCCTTGTTCGATTTTAAATGGCAGGCAGGCTAGAACCTCTGTTTTATCTATGTCTTTTGCTAATTATGGTCAGCATTTGGATGCAGGCTGCAAGGTTTATCACAATGCTCCGCGGACTTCAAGTACGTTGATTTCTAAATCAGTTGCCAAAGATGGCGGTAAAACCGATTATCGAGGTTCTGTTACTTTTGGAAAAAACAGTGCTGGTTCTAAATCACATATTGAATGTGATACGATTTTAATGGATGGCGAGTCTAGTTCAGATACGATCCCTTTCAATGAAATCCACAATTCAGATGTTTCTTTGGAGCATGAAGCAAAGGTTTCTAAAGTATCTGAAGAACAACTTTATTATATTATGAGCCGTGGGATTAGTGAGGAAGAGGCAACTGCTATGATTATCAATGGTTTCATGGATCCTATTACTAAAGAACTTCCGATGGAATACGCTGTAGAATTAAATGCACTTATTAATATGAGTATGGAAGGTTCGGTTGGTTAG","4.90","-17.07","51573","MKNRDYAFGFHDDVKPLYSTGKGLTEEVVRDISEIKNEPQWMLDYRLRCLELFYKLPMPKWGPDLSGINFNDVIYYQKLSGQPSRSWDDVPDDIKKTFERLGIPNAERQFLSGAVAQYESEVVYHNMKEEFEKMGIIFTDTDTALQEYPDLVKKYFASVVSPAEHKFAALNGAVWSGGTFIYVPKGVQCQIPVQTYFRINGENAGQFERSLMIIEEGASIQYIEGCTAPTYSTNSLHAATVEIIVKRDASFRYTTIQNWSDNVYNLVTERGTVEENGTLEWIDGNLGSKVNMKYPCSILNGRQARTSVLSMSFANYGQHLDAGCKVYHNAPRTSSTLISKSVAKDGGKTDYRGSVTFGKNSAGSKSHIECDTILMDGESSSDTIPFNEIHNSDVSLEHEAKVSKVSEEQLYYIMSRGISEEEATAMIINGFMDPITKELPMEYAVELNALINMSMEGSVG","1219116","","conserved hypothetical protein","Cytoplasm, Extracellular","Several matches in gapped BLAST to conserved hypothetical protein: residues 5-460 are 70% similar to gi|15674464| from S.pyogenes and are 68% similar to gi|15673770| from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0145 (0.0).","

InterPro
IPR000825
Family

SufBD
PF01458	$\"[199-431]T$	UPF0051

InterPro
IPR010231
Family

FeS assembly protein SufB
TIGR01980	$\"[4-451]T$	sufB: FeS assembly protein SufB

","BeTs to 11 clades of COG0719COG name: Predicted membrane components of an uncharacterized iron-regulated ABC-type transporter SufBFunctional Class: RThe phylogenetic pattern of COG0719 is amtK--VCEBR------LIN-Number of proteins in this genome belonging to this COG is 3","***** IPB000825 (Uncharacterized protein family UPF0051) with a combined E-value of 1.4e-29. IPB000825 382-432","Residues 173-456 are 70% similar to a (PROTEOME COMPLETE YCF24 CHLOROPLAST INTEIN ABC) protein domain (PD003219) which is seen in Q9CEP8_LACLA.Residues 181-432 are 23% similar to a (PROTEOME MJ0034 COMPLETE PH0883) protein domain (PD131349) which is seen in Y034_METJA.Residues 117-171 are 58% similar to a (PROTEOME COMPLETE YURX YSFA) protein domain (PD353460) which is seen in Q9XAD1_STRCO.Residues 5-116 are 63% similar to a (PROTEOME COMPLETE YCF24 CHLOROPLAST) protein domain (PD005891) which is seen in Q9CEP8_LACLA.Residues 116-171 are 46% similar to a (YCF24 PROTEOME TRANSPORTER ABC) protein domain (PD228408) which is seen in YC24_CYAPA.Residues 163-435 are 25% similar to a (PROTEOME COMPLETE MEMBRANE SUFD) protein domain (PD040896) which is seen in YE62_MYCTU.Residues 117-171 are 69% similar to a (PROTEOME COMPLETE INTEIN CLEAVAGE) protein domain (PD282952) which is seen in Q9CEP8_LACLA.Residues 326-432 are 29% similar to a (PROTEOME COMPLETE SLR0076 TC0058) protein domain (PD328727) which is seen in Q9PLP1_CHLMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 15:22:21 2002","Wed Feb 27 15:22:21 2002","Wed Feb 27 15:22:21 2002","Wed Feb 27 15:22:21 2002","Wed Feb 27 15:22:21 2002","Wed Feb 27 15:22:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1180 is paralogously related (blast p-value < 1e-3) to SMu0228, and SMu0225 both conserved hypotheticals.","Wed Feb 27 15:22:21 2002","","No significant hits to the NCBI PDB database.","SMU.1293c","","Residues 199 to 431 (E-value = 2.2e-101) place SMu1180 in the UPF0051 family which is described as Uncharacterized protein family (UPF0051) (PF01458)","Wed Feb 27 15:22:21 2002","24379709","","","","","","1","","","SMU.1293c","" "SMu1181","1221086","1220643","444","ATGGCTTTCGCTAAGATTGTTTTTGCTAGTATGACAGGAAATACGGAGGAAATTGCTGATATTGTTGCTCAGAAACTTGAGGAGCTAGGACATACGGTTGATGTTGATGAATGCACCACTGTTGATGCTGATGAATTTCAAGATGCTGATATTGCTATTGTAGCAAGCTATACTTATGGTGATGGCGAGCTTCCTGATGAAATTGTCGATTTTTATGAAGATTTGCAAGACTTAGATTTATCTGGGAAAATCTATGGTGTTGTTGGTTCAGGAGATACCTTCTATGATTATTTTTGTAAGGCTGTTGATGATTTTGAAATGGCTTTCGAAGGAACAGGGGCGACAAAGGGAGCAGAATCTGTTAAGGTTGACTTAGCAGCGGAAGATGAAGACATTGAAAATCTCGAAAAATTTGCCCAAGAAATTGCTGAAAAGGCAGAATAA","3.60","-30.83","16026","MAFAKIVFASMTGNTEEIADIVAQKLEELGHTVDVDECTTVDADEFQDADIAIVASYTYGDGELPDEIVDFYEDLQDLDLSGKIYGVVGSGDTFYDYFCKAVDDFEMAFEGTGATKGAESVKVDLAAEDEDIENLEKFAQEIAEKAE","1220658","","flavodoxin","Cytoplasm","Several matches in gapped BLAST to flavodoxin: residues 1-144 are 79% similar to the protein in S.pyogenes (gi|15674777|). Residues 1-145 are 77% similar to the protein from S.pneumoniae (gi|15901157|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0539 (3e-63).","

InterPro
IPR001094
Domain

Flavodoxin-like
PR00369	$\"[5-18]T$ $\"[53-64]T$ $\"[82-92]T$	FLAVODOXIN

InterPro
IPR001226
Domain

Flavodoxin, N-terminal
PS00201	$\"[6-22]T$	FLAVODOXIN

InterPro
IPR008254
Domain

Flavodoxin/nitric oxide synthase
PF00258	$\"[6-138]T$	Flavodoxin_1
PS50902	$\"[4-143]T$	FLAVODOXIN_LIKE

InterPro
IPR010087
Family

Flavodoxin, short chain
TIGR01753	$\"[4-143]T$	flav_short

InterPro
IPR014357
Family

Flavodoxin
PIRSF000088	$\"[1-145]T$	Flavodoxin

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[4-145]T$	G3DSA:3.40.50.360
PTHR19384	$\"[11-147]T$	PTHR19384
PTHR19384:SF18	$\"[11-147]T$	PTHR19384:SF18
SSF52218	$\"[1-146]T$	SSF52218

","BeTs to 5 clades of COG0716COG name: FlavodoxinsFunctional Class: CThe phylogenetic pattern of COG0716 is amT----cEB-huj---l---Number of proteins in this genome belonging to this COG is 1","***** IPB001226 (Flavodoxin) with a combined E-value of 4.3e-11. IPB001226A 6-22 IPB001226C 82-93***** PR00369 (Flavodoxin signature) with a combined E-value of 8.5e-07. PR00369A 5-18 PR00369B 53-64 PR00369C 82-92","Residues 12-115 are 73% similar to a (FMN FLAVOPROTEIN OXIDOREDUCTASE NADP) protein domain (PD000452) which is seen in Q9CHW0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 09:22:35 2002","Wed Feb 27 15:26:22 2002","Tue Oct 22 09:22:35 2002","Wed Feb 27 15:26:22 2002","Wed Feb 27 15:26:22 2002","Wed Feb 27 15:26:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1181 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 22 09:22:35 2002","Wed Feb 27 15:26:22 2002","pdb|2FX2| Flavodoxin >gi|443463|pdb|3FX2| Flavodoxin (Low ... 80 2e-016pdb|1BU5|A Chain A, X-Ray Crystal Structure Of The Desulfovibri... 79 2e-016pdb|1FX1| Flavodoxin 79 3e-016","SMU.1294c","","Residues 6 to 138 (E-value = 4.2e-26) place SMu1181 in the Flavodoxin_1 family which is described as Flavodoxin (PF00258)","Wed Feb 27 15:26:22 2002","","","","","","","1","","","SMU.1294c","656" "SMu1182","1222194","1221145","1050","ATGATAGATAGCAATAGAAAGTGGAGTCTGATAATGAAAAATACTTTACATAATTTAGTAAAGACCGAATTACATTGCCATTTGGATGGGTCTCTATCATTTGAGACTATTCGAGAATTAGCTGAAATGGCGAATATAGCGCTGCCTGAATCAGATAGTGAACTTGCAAAATTGGTCACTGTTCCTGAGGATTCTGAGACCTTGCTTGATTATTTAAAAACTTTTGACTTTATTCGACCACTGTTACAGACACAAAAAGCGCTTAGTTTAGCAGCTTATGATGTGGCCAAGCAGGCTGCTGCTGAACATGTGCTTTATATTGAAATTCGCTTTGCTCCCGAATTATCTATGGATAAGGGATTGAGTGCTGTTCAGGTAGTTGAGGCGGTTGAAAAAGGTCTGCAAAAGGCTCAAAGGGATTTTAATATTGTTGCCAAGGTTTTAATTTGTGGGATGAGACAGTCCTCAAAACAGTTGACAAAAGAGATTTTTCGTCAAATTAACCAAGCCAAAAGTTTAGAATTTGCAGGCTTTGACTTTGCAGGAAATGAACATGATTTTCCGCCACAAGAAATAGCAGATCTCATTCGTTTTACGCAAAGATTGGATCGTCCTATGACTTTTCATGCTGGTGAATGTGGCTGTCCTAGCCATATTGCCCAATCAATTGCCTTAGGAATCAAACGTTTGGGGCATGTCACAGCTATCCATGACCATCCGGAATTGATAGCAGACTTTGTTGAGAATAAAGTGACAGCAGAACTTTGCCTAACCAGTAACCTTCAAACTAAGGCAGCCAAATCTCTAGCGGAATTTCCCTATCAAGAGCTCTATGAAGCTGGTGCTAAGATAACAATTAACACGGATAACCGTACTGTCTCCAATACCAATTTAACGAAGGAATATCAGTTATTTGTGGATTATTTCGGAACCAGTTTGGCAGATTTTTATCACTTTAATCAAAATGCGATTGAGGCATCTTTTGCCTCTGAAGCTGAAAAGGCAGAACTTTTGGCTGAACTGAAAAAGGCCTATGGACAGACTGATTAA","5.20","-11.56","39093","MIDSNRKWSLIMKNTLHNLVKTELHCHLDGSLSFETIRELAEMANIALPESDSELAKLVTVPEDSETLLDYLKTFDFIRPLLQTQKALSLAAYDVAKQAAAEHVLYIEIRFAPELSMDKGLSAVQVVEAVEKGLQKAQRDFNIVAKVLICGMRQSSKQLTKEIFRQINQAKSLEFAGFDFAGNEHDFPPQEIADLIRFTQRLDRPMTFHAGECGCPSHIAQSIALGIKRLGHVTAIHDHPELIADFVENKVTAELCLTSNLQTKAAKSLAEFPYQELYEAGAKITINTDNRTVSNTNLTKEYQLFVDYFGTSLADFYHFNQNAIEASFASEAEKAELLAELKKAYGQTD","1221160","","adenosine deaminase","Cytoplasm","Several matches in gapped BLAST to adenosine deaminase: residues 6-324 are 42% similar to the enzyme in Lactococcus lactis (gi|15672269|). Residues 15-324 are 36% similar to the protein from S.coelicolor (gi|7480424|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0538 (1e-110).","

InterPro
IPR001365
Domain

Adenosine/AMP deaminase
PTHR11409	$\"[125-347]T$	A/AMP_deaminase
PF00962	$\"[18-340]T$	A_deaminase

InterPro
IPR006330
Family

Adenosine deaminase
TIGR01430	$\"[19-341]T$	aden_deam

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.140	$\"[14-346]T$	G3DSA:3.20.20.140
PTHR11409:SF21	$\"[125-347]T$	PTHR11409:SF21
SSF51556	$\"[14-346]T$	SSF51556

","BeTs to 4 clades of COG1816COG name: Adenosine deaminaseFunctional Class: FThe phylogenetic pattern of COG1816 is ----y---e-r------l---Number of proteins in this genome belonging to this COG is 1","***** IPB001365 (Adenosine and AMP deaminase) with a combined E-value of 3.7e-07. IPB001365A 17-39 IPB001365F 310-337","Residues 21-274 are 42% similar to a (ADENOSINE DEAMINASE HYDROLASE PROTEOME) protein domain (PD008716) which is seen in Q9CIR9_LACLA.Residues 22-143 are 33% similar to a (ADENOSINE NUCLEOTIDE METABOLISM DEAMINASE) protein domain (PD397165) which is seen in ADD_ECOLI.Residues 176-260 are 31% similar to a (ANTIGEN GRO TH ATRIAL) protein domain (PD191499) which is seen in Q9NC65_LUTLO.Residues 275-324 are 50% similar to a (PROTEOME ADENOSINE COMPLETE DEAMINASE) protein domain (PD389992) which is seen in Q9CIR9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 08:48:38 2002","Thu Feb 28 08:43:57 2002","Thu Oct 17 16:29:00 2002","Thu Feb 28 08:43:57 2002","Thu Feb 28 08:43:57 2002","Thu Feb 28 08:43:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1182 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 08:48:38 2002","Thu Feb 28 08:43:57 2002","pdb|2ADA| Adenosine Deaminase (E.C.3.5.4.4) Complexed With 6-... 100 2e-022pdb|1A4M|A Chain A, Ada Structure Complexed With Purine Ribosid... 100 2e-022pdb|1FKX| Murine Adenosine Deaminase (D296a) 99 6e-022","SMU.1295c","","Residues 18 to 340 (E-value = 3.5e-58) place SMu1182 in the A_deaminase family which is described as Adenosine/AMP deaminase (PF00962)","Thu Feb 28 08:43:57 2002","","","","Chang,Z.Y., Nygaard,P., Chinault,A.C. and Kellems,R.E.Deduced amino acid sequence of Escherichia coli adenosine deaminase reveals evolutionarily conserved amino acid residues: implications for catalytic functionBiochemistry 30 (8), 2273-2280 (1991)PubMed: 1998686","","Thu Feb 28 08:48:38 2002","1","","","SMU.1295c","537" "SMu1183","1222269","1223060","792","ATGTCTTACTATATTCCACCAAAAGTTTGGTCAGCTGAGGAAAGCAACCAAGGAAAATTTTCTGCTATCAATCGTCCAACTGCTGGCAGTCGTTTTGACCAAAAACTACCCCAAGGTGATAAACCATTACAGGTTTATTCATTAGGAACTCCTAACGGACTCAAAGTAGCCGTAATGTTGGAAGAGTTACGCGAACTTGGTGTCAAAGAAGCAGATTATGACCTCTTCAAAATTTCAATCATGGATGGCGACCAATTTGGTTCTGATTTTGTTGCCATTAACCCCAATTCTAAAATTCCTTCTCTTTTGGATAAGTCTAATAGAGAAGCTATTCGCGTCTTTGAATCTGGTTCTATCTTACTTTATTTGGCTGATAAATTTAACCATCTTATTCCTGTAGATTGGGCACAAAGAACAGAAGTTCTTAACTGGCTCTTCTGGCAAATGGGGGCTGCTCCCTTTGTTGGCGGCGGTTTCGGTCACTTTTTCAGCTATGCTCCTGAAAAATTAGAATATCCTATCAATCGTTTTACCATGGAAACCAAGCGCCAATTGGACTTATTGAATAAAGAATTAGCTAATAAGCCCTACATTGCAGGTGAAGATTATACCATTGCCGATATAGCTATCTGGTCTTGGTATGGACGTTTAGCACAAGATGCCCTTTATGAAGGAGCTTATAAATTTCTCGCTTTAGGCACCTATCAACACTTATTAGACTGGACTGAAAGAATCGCTCAGCGTCCAGCTGTCAAGCGAGCATTGGAAGTTGATTATAAAGCTATCAAATAA","5.90","-2.27","29978","MSYYIPPKVWSAEESNQGKFSAINRPTAGSRFDQKLPQGDKPLQVYSLGTPNGLKVAVMLEELRELGVKEADYDLFKISIMDGDQFGSDFVAINPNSKIPSLLDKSNREAIRVFESGSILLYLADKFNHLIPVDWAQRTEVLNWLFWQMGAAPFVGGGFGHFFSYAPEKLEYPINRFTMETKRQLDLLNKELANKPYIAGEDYTIADIAIWSWYGRLAQDALYEGAYKFLALGTYQHLLDWTERIAQRPAVKRALEVDYKAIK","1223069","","glutathione S-transferase","Cytoplasm","Several matches in gapped BLAST to glutathione S-transferase: residues 1-263 are 69% similar to the enzyme in S.pneumoniae (gi15901393). Residues 4-253 are 61% similar to the protein from Yersinia pestis (gi16123781).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0800 (4e-07).","

InterPro
IPR004046
Domain

Glutathione S-transferase, C-terminal
PF00043	$\"[180-249]T$	GST_C

InterPro
IPR010987
Domain

Glutathione S-transferase, C-terminal-like
G3DSA:1.20.1050.10	$\"[126-258]T$	GST_C_like
SSF47616	$\"[122-256]T$	GST_C_like

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[28-133]T$	IPR012336

noIPR
unintegrated

unintegrated
PTHR11260	$\"[43-255]T$	PTHR11260
PTHR11260:SF8	$\"[43-255]T$	PTHR11260:SF8

","BeTs to 4 clades of COG0625COG name: Glutathione-S-transferasesFunctional Class: OThe phylogenetic pattern of COG0625 is ----Y--cE--H--------xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 129-253 are 56% similar to a (TRANSFERASE GLUTATHIONE S-TRANSFERASE GST FAMILY) protein domain (PD319906) which is seen in YGHU_ECOLI.Residues 43-125 are 39% similar to a (PROTEOME COMPLETE TRANSFERASE) protein domain (PD287188) which is seen in Q9I4F3_PSEAE.Residues 45-94 are 64% similar to a (GLUTATHIONE TRANSFERASE S-TRANSFERASE ISOMERASE) protein domain (PD000443) which is seen in YGHU_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:35:36 2002","Thu Feb 28 08:53:45 2002","Thu Mar 1 11:21:07 2007","Thu Feb 28 08:53:45 2002","","Thu Feb 28 08:53:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1183 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 16:35:36 2002","Thu Mar 1 11:21:07 2007","pdb1F2EA Chain A, Structure Of Sphingomonad, Glutathione S-Tr... 67 3e-012pdb1AW9 Structure Of Glutathione S-Transferase Iii In Apo ... 64 3e-011","SMU.1296","","No significant hits to the Pfam 11.0 database","Thu Feb 28 08:53:45 2002","24379712","","","","","","1","","","SMU.1296","" "SMu1184","1223132","1224064","933","ATGACTGCTTTTAAAACTATTCTAGCTAAAATCAAAGCTTATGACACCATTATTATTCACCGCCATATGAAACCAGACCCTGACGCATTAGGCAGTCAGGTCGGCTTGAAAGAAATGATTACAAGCAATTTCCCCCAAAAGACGGTGAAAGTAACAGGTTATAATGAACCTAGCCTTTCTTGGCTGGCTCAAATGGATGACGTATCTGATAAGGATTACGAAGGAGCTTTGGTCATCGTTGTTGACACAGCTAATCGTCCGCGTATTGATGATCAACGCTATTTAAATGGTAACTTTCTTATTAAAATTGATCACCATCCTGATGAAGACCATTATGGTGACTTATCTTATGTTGATACCAAGGCTTCTAGTGCTAGTGAAATTATCACTGACTTTGCCCTGCAAAATCAACTGAAACTTTCAGATCAAGCAGCCCGTTTGCTTTATGCAGGGATTCTTGGTGATACAGGGCGCTTTCTTTATCCAGCAACAACGTCAAAAACATTTATCATTGCCAGTGAGCTCCTCAAATATGACTTTGATTTTGCTGCCTTAGCACGTCAAATGGATTCTTTCCCTTATAAAATTGCCAAATTACAAGCTTACGTTTTTGAAAATCTTGAAATTGATAAAAACGGTGCAGCACGTATTATTTTAAGCCAGAAAATCCTGAAAAAATTTAATTTGACTGACGCCGAAACATCTGCTATCGTTTCTAGCCCAGGGAAAATTGATACTGTCCAAGTTTGGGCCATTTTTGTGGAACAAGCAGATGGCCATTACCGCGTACGCCTACGCAGCAAGTCCACTGTCATCAATGAAGTTGCCAAAAGACATGCTGGTGGCGGCCATCCATTAGCAAGTGGTGCCAATTCTTATAGTTTGGCAGAAAATGAGGACATTTATCAGGAATTAAAAAATCTGCTAAAATAG","6.50","-2.06","34672","MTAFKTILAKIKAYDTIIIHRHMKPDPDALGSQVGLKEMITSNFPQKTVKVTGYNEPSLSWLAQMDDVSDKDYEGALVIVVDTANRPRIDDQRYLNGNFLIKIDHHPDEDHYGDLSYVDTKASSASEIITDFALQNQLKLSDQAARLLYAGILGDTGRFLYPATTSKTFIIASELLKYDFDFAALARQMDSFPYKIAKLQAYVFENLEIDKNGAARIILSQKILKKFNLTDAETSAIVSSPGKIDTVQVWAIFVEQADGHYRVRLRSKSTVINEVAKRHAGGGHPLASGANSYSLAENEDIYQELKNLLK","1224073","","conserved hypothetical protein, DHH family","Cytoplasm","Limited matches in gapped BLAST to conserved hypotheticals: residues 1-305 are 67% similar to gi15674776 from S.pyogenes and residues 7-310 are 61% similar to gi15672717 from Lactococcus lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0537 (1e-129).","

InterPro
IPR001667
Domain

Phosphoesterase, RecJ-like
PF01368	$\"[10-153]T$	DHH

InterPro
IPR003156
Domain

Phosphoesterase, DHHA1
PF02272	$\"[248-307]T$	DHHA1

noIPR
unintegrated

unintegrated
G3DSA:3.90.1640.10	$\"[14-178]T$	no description
PTHR13734	$\"[7-300]T$	TRNA-NUCLEOTIDYLTRANSFERASE/POLY(A) POLYMERASE FAMILY MEMBER
PTHR13734:SF4	$\"[7-300]T$	POLYA POLYMERASE

","BeTs to 11 clades of COG0618COG name: Exopolyphosphatase-related proteinsFunctional Class: RThe phylogenetic pattern of COG0618 is aM-K-QVC-Br---GPoL---Number of proteins in this genome belonging to this COG is 2","***** IPB001667 (DHH family) with a combined E-value of 1.5e-09. IPB001667A 24-37 IPB001667B 100-107 IPB001667C 281-289","Residues 100-175 are 41% similar to a (COMPLETE PROTEOME HYDROLASE MANGANESE) protein domain (PD003055) which is seen in Q9CHI7_LACLA.Residues 7-75 are 57% similar to a (PROTEOME COMPLETE MGPA YHEB) protein domain (PD023652) which is seen in Q9K834_BACHD.Residues 11-62 are 44% similar to a (MGPA) protein domain (PD118480) which is seen in MGPA_MYCGE.Residues 100-309 are 63% similar to a (COMPLETE PROTEOME MG371 UU417) protein domain (PD370564) which is seen in Q9CHJ6_LACLA.Residues 22-289 are 24% similar to a (PROTEOME COMPLETE) protein domain (PD118484) which is seen in P71615_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 08:59:32 2002","Thu Sep 7 16:56:35 2006","Thu Sep 7 16:56:35 2006","Thu Feb 28 08:58:45 2002","Thu Feb 28 08:58:45 2002","Thu Feb 28 08:58:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1184 is paralogously related (blast p-value < 1e-3) to SMu1942, a predicted conserved hypothetical protein.","Thu Feb 28 08:59:32 2002","","No significant hits to the NCBI PDB database.","SMU.1297","","Residues 10 to 153 (E-value = 2.3e-42) place SMu1184 in the DHH family which is described as DHH family (PF01368)Residues 248 to 307 (E-value = 6e-06) place SMu1184 in the DHHA1 family which is described as DHHA1 domain (PF02272)","Thu Sep 7 16:56:35 2006","24379713","","","","","","1","","","SMU.1297","299" "SMu1185","1224161","1224403","243","ATGAAAAAAGATATTCATCCAGAATACCGTCCAGTTGTCTTTATGGATACTTCAACGGGTTACCAATTCCTCAGCGGTTCAACTAAGACGTCAAAAGAAACCGTTGAATTTGAAGGCGAAACTTATCCACTTATCCGCGTTGAAATTTCATCAGACTCACATCCATTCTATACAGGACGTCAAAAATTCACACAAGCAGATGGACGTGTCGACCGTTTCAACAAAAAATACGGCCTCAAATAA","9.80","2.47","9286","MKKDIHPEYRPVVFMDTSTGYQFLSGSTKTSKETVEFEGETYPLIRVEISSDSHPFYTGRQKFTQADGRVDRFNKKYGLK","1224412","For other 'rpm' genes see SMu0638 (rpmI);SMu0108 (rpmB);SMu0773 (rpmA); SMu0306 (rpmH) and SMu1464 (rpmG). ","50S ribosomal protein L31","Cytoplasm, Extracellular","Several matches in gapped BLAST to 50S ribosomal protein L31: residues 1-80 are 96% similar to the protein in S.pneumoniae (gi|15901159|) and are 93% similar to the protein from S.pyogenes (gi|15674775|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0536 (9e-42).","

InterPro
IPR002150
Family

Ribosomal protein L31
PR01249	$\"[2-19]T$ $\"[44-59]T$ $\"[59-77]T$	RIBOSOMALL31
PF01197	$\"[1-80]T$	Ribosomal_L31
TIGR00105	$\"[1-80]T$	L31
PS01143	$\"[48-69]T$	RIBOSOMAL_L31

","BeTs to 11 clades of COG0254COG name: Ribosomal protein L31Functional Class: JThe phylogenetic pattern of COG0254 is -----qvcEBrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002150 (Ribosomal protein L31) with a combined E-value of 7.8e-20. IPB002150 47-77","Residues 1-78 are 78% similar to a (RIBOSOMAL 50S PROTEOME COMPLETE) protein domain (PD003785) which is seen in Q9CF85_LACLA.Residues 1-77 are 38% similar to a (PROTEOME COMPLETE RIBOSOMAL ADDITIONAL) protein domain (PD413791) which is seen in Q9JUT8_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:37:41 2002","Thu Feb 28 09:05:08 2002","Thu Oct 17 16:37:41 2002","Thu Feb 28 09:02:22 2002","Thu Feb 28 09:02:22 2002","Thu Feb 28 09:02:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1185 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 09:02:22 2002","","No significant hits to the NCBI PDB database.","SMU.1298","","Residues 1 to 80 (E-value = 3.9e-24) place SMu1185 in the Ribosomal_L31 family which is described as Ribosomal protein L31 (PF01197)","Thu Feb 28 09:02:22 2002","24379714","","","","","","1","","","SMU.1298","780" "SMu1186","1224766","1224443","324","ATGATTGATAATCTTTTAGACTTGATAAAATACCATGATGGACAAATTGCCAGTCGCTCATTGAATAAAAAGTTGGAAATAGAAAACCCTATTACTCTCTATGCTATGCCAGCTGGTGAGTCTATTAGCAATGAAAGCAGCAAATTAGCCAAATTGATTCAGGTTTTAGAAGGCAGCCTGCAAGTGGAAATAGCGGGAGAAAAGCATATTATTAATCATCAAGGATTGATTAGCATTGCTGCCAATCAGGTGCATAATCTCTATGCCCTTAAAGACAGTAAAGTGTTGCAAATAGAAGTGGAGTCACAAAAGAAGCTTATATAA","6.50","-1.05","11855","MIDNLLDLIKYHDGQIASRSLNKKLEIENPITLYAMPAGESISNESSKLAKLIQVLEGSLQVEIAGEKHIINHQGLISIAANQVHNLYALKDSKVLQIEVESQKKLI","1224458","","methyltransferase, possible acetate kinase","Cytoplasm","Limited matches in gapped BLAST to acetate kinase: residues 1-101 are 48% similar to gi9965180 from S.agalactiae.Residues 1-98 are 47% similar to gi15675469 from S.pyogenes.SMu1186 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR011051
Domain

Cupin, RmlC-type
SSF51182	$\"[31-100]T$	RmlC_like_cupin

","BeTs to 3 clades of COG1917COG name: Uncharacterized ACR, double-stranded beta-helix domainFunctional Class: SThe phylogenetic pattern of COG1917 is --tk-qvc--r-uj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 7-96 are 31% similar to a (PROTEOME COMPLETE) protein domain (PD067066) which is seen in O27501_METTH.Residues 1-101 are 48% similar to a (KINASE ACETATE) protein domain (PD284756) which is seen in Q9F8C0_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:38:33 2002","Thu Sep 28 10:37:51 2006","Thu Sep 28 10:37:51 2006","Thu Feb 28 09:36:07 2002","","Thu Feb 28 09:36:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1186 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 09:36:07 2002","","No significant hits to the NCBI PDB database.","SMU.1299c","","No significant hits to the Pfam 11.0 database","Thu Feb 28 09:36:07 2002","24379715","","","","","","1","","","SMU.1299c","" "SMu1187","1225106","1224759","348","ATGGTTTATATTGACAAGATTCAGCACAGTCAGGTATTAGACTTAAAAACAGAAGTCCCAATTGAAGAAGAGCAAATGCTCAGTAAAACCTTGGTTCAACGAAAAGACTTGGGCATGACTATTTTTTCTTTAGATAAAGATCAAGAAATTGGTCGACATTGCTCACCCGGTGATGCTATGGTTAATATTTTGAGTGGTTTAGCTGAAATCACCATTGATGAAGAAGTCTTTGAAGTAGCAGCTGGTCAGACCGTTGTTATGCCAGCCAATATTCCGCATAGTCTGTATGCAAAAGAGGCTTTTCAAATGCTTCTAGTCGTTGTGAAACCAGAGGTAGACCATGATTGA","4.40","-10.09","12848","MVYIDKIQHSQVLDLKTEVPIEEEQMLSKTLVQRKDLGMTIFSLDKDQEIGRHCSPGDAMVNILSGLAEITIDEEVFEVAAGQTVVMPANIPHSLYAKEAFQMLLVVVKPEVDHD","1224774","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 1-112 are 83% similar to S.agalactiae (gi|9965181|) and residues 1-111 are 75% similar to S.pyogenes (gi|15675470|).SMu1187 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003439
Domain

ABC transporter related
PS00211	$\"[54-68]?$	ABC_TRANSPORTER_1

InterPro
IPR011051
Domain

Cupin, RmlC-type
SSF51182	$\"[17-110]T$	RmlC_like_cupin

InterPro
IPR013096
Domain

Cupin 2, conserved barrel
PF07883	$\"[40-107]T$	Cupin_2

InterPro
IPR014710
Domain

RmlC-like jelly roll fold
G3DSA:2.60.120.10	$\"[26-108]T$	RmlC-like_jellyroll

","BeTs to 4 clades of COG0662COG name: Mannose-6-phosphate isomeraseFunctional Class: GThe phylogenetic pattern of COG0662 is amTK-qvCebr-uj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 12-109 are 86% similar to a (PROTEOME COMPLETE) protein domain (PD067066) which is seen in Q9F8B9_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 09:43:17 2002","Thu Feb 28 09:43:17 2002","Thu Feb 28 09:43:17 2002","Thu Feb 28 09:43:17 2002","","Thu Feb 28 09:43:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1187 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 09:43:17 2002","","No significant hits to the NCBI PDB database.","SMU.1300c","","No significant hits to the Pfam 11.0 database","Thu Feb 28 09:43:17 2002","24379716","","","","","","1","","","SMU.1300c","" "SMu1188","1225915","1225160","756","ATGACAAAAAAAGAAGTTGGCCATAACTTTCTGGCTCGTTTAGGCAAGAAACGTTTACGTCCCGGTGGAATTACAGCCACCAATTGGTTAATAGAACAAGGACAGTTCAGTAAGGACAGCCACGTGTTGGAAGTCGCTTGCAATATGTGTACAACCTCGATAGAACTGGCGCAAACTTACGGTTGTTCAATTGAAGGTGTAGATAGGGATCCTAAGGCCTTGGAAAAAGCGCGTGCTAATATCTGTGAAGCAGGCTTGGATGAATTGGTTCATGTGCAGCAAGCTAACGCTATGAAACTGCCTTTTCCCGATGATTCTTTTGATATTATTATTAATGAAGCCATGTTGACCATGTTAGGCGATGAAGCCAAGATTAAGGCTATTAAGGAATATTTGCGTGTTTTGAAACCCGGCGGACGTCTCTTAACGCATGATGTTTCTTTTACAGAAGAAAGGATGGAAGAACAATTAGCAAGTTTACGGCAAACCATCAATGCTAATGTTGAACCTCTGCATGTTGCTGATTGGCAAAAGTTGTTTGAAGAGCAGGGCTTCTCATCTGTCAAACTGAACTATGGTAAAATGACCCTCATGTCTATTTTGGGAATGATTAAGGATGAAGGGTTTTGGGGAACTCTAAGAATTACTTACAGAGGTTTGAAGAAAGAAAACCGTCAGCAATTTCTGAAAATGTACCGCTTCTTTAACAAAGCAGGAAAAGATTTGATCTATATTGCAGTTTGCAGTACAAAATAA","8.30","3.98","28470","MTKKEVGHNFLARLGKKRLRPGGITATNWLIEQGQFSKDSHVLEVACNMCTTSIELAQTYGCSIEGVDRDPKALEKARANICEAGLDELVHVQQANAMKLPFPDDSFDIIINEAMLTMLGDEAKIKAIKEYLRVLKPGGRLLTHDVSFTEERMEEQLASLRQTINANVEPLHVADWQKLFEEQGFSSVKLNYGKMTLMSILGMIKDEGFWGTLRITYRGLKKENRQQFLKMYRFFNKAGKDLIYIAVCSTK","1225175","","methyltransferase related segment","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins and to methyltransferase: residues 1-251 are 64% similar to S.agalactiae (gi9965182) and 63% similar to conserved hypothetical protein from S.pyogenes (gi15675471).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0952 (5e-04).","

InterPro
IPR013216
Domain

Methyltransferase type 11
PF08241	$\"[43-143]T$	Methyltransf_11

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[28-237]T$	G3DSA:3.40.50.150
PTHR10108	$\"[28-208]T$	PTHR10108
PTHR10108:SF36	$\"[28-208]T$	PTHR10108:SF36
SSF53335	$\"[24-251]T$	SSF53335

","BeTs to 9 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 42-110 are 71% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME SYNTHASE ACID) protein domain (PD000198) which is seen in Q9CLQ7_PASMU.Residues 42-110 are 68% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME ARGININE) protein domain (PD006760) which is seen in Y095_HAEIN.Residues 160-251 are 65% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD074534) which is seen in Q9F8B8_STRAG.Residues 7-251 are 32% similar to a (PROTEOME COMPLETE) protein domain (PD074508) which is seen in O06190_MYCTU.Residues 62-151 are 66% similar to a (METHYLTRANSFERASE) protein domain (PD074356) which is seen in Q9F8B8_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:38:58 2002","Thu Sep 28 10:45:42 2006","Thu Sep 28 10:45:42 2006","Thu Feb 28 09:46:49 2002","","Thu Feb 28 09:46:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1188 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 09:46:49 2002","","No significant hits to the NCBI PDB database.","SMU.1301c","","No significant hits to the Pfam 11.0 database","Thu Feb 28 09:46:49 2002","24379717","","","","","","1","","","SMU.1301c","" "SMu1189","1227596","1226076","1521","ATGCGGAAAAAACCTTTTATTATCGTTTCTCTTCTGTTAGTCATTTTAGCGGTTGTGATAGCTTTTCTATTGGCAAAAGATGGAGAGAAGAGAAGTAATGGTAAACTTAATGTGGTCACAACCTTTTATCCTATGTATGAATTTACAAAAAATGTTGTTGGTGATCAAGGCAAGGTGTCTCTATTGATTAAGGCAGGAACGGAAGTTCATGATTTTGAACCTTCAACCAAAGATGTGACAAGGATTCAAGAGGCAGATACTTTTGTTTATGATTCTGACAGTATGGAAACTTGGGTTAAATCTGTTAAAAAATCTGTTGATACCCAAAAAGTGCCATTTGTAAAAGCAACAGGTAATATGATTTTAGCACCAGGAGTAACAGAAGAAGAAGGACATGGTCACAAAGGGCATCACCATGCTTATGATCCTCACGTTTGGCTGTCACCAAAACGTGCTATTAAGTTGGTGGAAAATATCCGTGACGCTCTTTCTAAAAAATTTCCTCGCCGTGCCAAAATCTTCAAGAAAAATGCAGCAAACTATATTGACAAACTTCAGACCTTGGACAAGGAATACGCAGAAGGTCTTGCAAATGCCAAGCAAAAATCTTTTGTTACGCAGCATGCGGCCTTTGGCTATTTAGCGCTTGATTATGGCTTGACTCAAATTCCAATTACAGGTTTAACAGCTGAGTCTGAACCTTCAGCTAAACGTTTGGCAGAACTTTCTAAATATGTTAAAGAGTATGGCATTAACTATATTTACTTTGAGGAAAACGCTTCATCAGCTGTTTCTAAAACTTTAGCTGATGAAGCTGGTGTTAAAACAGCTGTGCTTAGTCCGCTTGAAAGTTTAACACAAAAGCAAATGGATGCAGGGGAAAATTATTTCTCCGTAATGCGTGCTAATCTAAAAGCTTTGAAAAAAACAACAGATTCTGCCGGTAAAGAAATCAAACCTGAAATGGATAGCGACAAGACAGTTGCTAATGGATATTTTAAAGATAAGAGTATCAAGAATCGCAAATTATCTGATTGGTCAGGAAAATGGCAATCTATTTATCCTTATTTAGAAAATGGAACCCTTGATAGTGTCTGGGATTATAAGGCCAAATCTAAAAAAGACATGACAGCTCAAGAGTACAAAGAATACTATACTAAGGGTTACAAGACAGATGTTGAAAAAATTACGATTGATGGTAAGAAGAACACTATTACTTTTGTGCAAAAGGGTAAGGAGCACAAATATACTTACAAATATGTAGGTTATAAAATCCTTACTTATAAAAAAGGAAATCGTGGTGTACGTTATCTCTTTGAAACTAAGGATAAAGGGGCTGGAGAATTCAAATATGTTCAGTTTAGTGACCATGGCATTAAATCACAAAAAGCAGAACACTTCCATCTTTTCTGGGGCAGCGAAAATCAAGATAAGTTATTGGAAGAAATGGAAAATTGGCCAACCTATTATCCAGCTAATTTGACAGGCCGACAAATTGCTCAAGAAATTGTAGCTCATTAA","10.10","18.17","57512","MRKKPFIIVSLLLVILAVVIAFLLAKDGEKRSNGKLNVVTTFYPMYEFTKNVVGDQGKVSLLIKAGTEVHDFEPSTKDVTRIQEADTFVYDSDSMETWVKSVKKSVDTQKVPFVKATGNMILAPGVTEEEGHGHKGHHHAYDPHVWLSPKRAIKLVENIRDALSKKFPRRAKIFKKNAANYIDKLQTLDKEYAEGLANAKQKSFVTQHAAFGYLALDYGLTQIPITGLTAESEPSAKRLAELSKYVKEYGINYIYFEENASSAVSKTLADEAGVKTAVLSPLESLTQKQMDAGENYFSVMRANLKALKKTTDSAGKEIKPEMDSDKTVANGYFKDKSIKNRKLSDWSGKWQSIYPYLENGTLDSVWDYKAKSKKDMTAQEYKEYYTKGYKTDVEKITIDGKKNTITFVQKGKEHKYTYKYVGYKILTYKKGNRGVRYLFETKDKGAGEFKYVQFSDHGIKSQKAEHFHLFWGSENQDKLLEEMENWPTYYPANLTGRQIAQEIVAH","1226091","For other components see SMu1811 (NBD1) and SMu1810 (MSD1).For other 'slo' genes see SMu0164 (sloA); SMu0165 (sloB); SMu0166 (sloC) and SMu0168 (sloR). For other'adc' genes see SMu1812 (adcR); SMu1811 (adcC) and SMu1810 (adcB). ","zinc ABC transporter, substrate-binding protein","Periplasm, Membrane, Extracellular","Matches in gapped BLAST to adhesion protein and to zinc ABC transporter:residues 29-304 are 24% similar to the previously published SloC in S.mutans (gi8925939). Residues 32-506 are 62% similar to adhesion protein in S.pyogenes (gi15674772).Residues 29-506 are 60% similar to zinc ABC transporter, zinc-binding lipoprotein in S.pneumoniae (gi15904016).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0535 (0.0).","

InterPro
IPR006127
Family

Periplasmic solute binding protein
PF01297	$\"[12-312]T$	SBP_bac_9

InterPro
IPR006128
Family

Adhesion lipoprotein
PR00690	$\"[35-53]T$ $\"[66-79]T$ $\"[79-96]T$ $\"[197-218]T$	ADHESNFAMILY

InterPro
IPR006129
Family

Adhesin B
PR00691	$\"[35-56]T$ $\"[60-78]T$ $\"[79-98]T$ $\"[141-160]T$ $\"[197-214]T$ $\"[290-308]T$	ADHESINB

InterPro
IPR011038
Domain

Calycin-like
SSF50814	$\"[318-506]T$	Calycin

InterPro
IPR012674
Domain

Calycin
G3DSA:2.40.128.20	$\"[312-506]T$	Calycin

InterPro
IPR015304
Domain

YodA
PF09223	$\"[323-506]T$	YodA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1980	$\"[34-197]T$ $\"[198-304]T$	G3DSA:3.40.50.1980
SSF53807	$\"[34-313]T$	SSF53807

","BeTs to 10 clades of COG0803COG name: Zn-binding (lipo)protein of the ABC-type Zn transport system (surface adhesin A)Functional Class: PThe phylogenetic pattern of COG0803 is a-tK-QvCeBrH-----LINxNumber of proteins in this genome belonging to this COG is 2","***** PR00691 (Adhesin B signature) with a combined E-value of 1.2e-14. PR00691A 35-56 PR00691B 60-78 PR00691C 79-98 PR00691D 141-160 PR00691E 197-214 PR00691I 290-308***** PR00690 (Adhesin family signature) with a combined E-value of 6.3e-12. PR00690A 35-53 PR00690B 66-79 PR00690C 79-96 PR00690D 197-218","Residues 28-125 are 53% similar to a (COMPLETE PERIPLASMIC PROTEOME PRECURSOR) protein domain (PD002751) which is seen in O34966_BACSU.Residues 142-225 are 52% similar to a (COMPLETE PROTEOME PERIPLASMIC) protein domain (PD002761) which is seen in O34966_BACSU.Residues 225-310 are 59% similar to a (PROTEOME COMPLETE BINDING LIPOPROTEIN) protein domain (PD404478) which is seen in Q9CG08_LACLA.Residues 315-506 are 57% similar to a (PROTEOME BINDING METAL COMPLETE) protein domain (PD037568) which is seen in Q9CG08_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 16:50:42 2006","Thu Sep 7 16:50:42 2006","Thu Sep 7 16:50:42 2006","Thu Feb 28 09:50:42 2002","Thu Feb 28 09:50:42 2002","Thu Feb 28 09:50:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1189 is paralogously related (blast p-value < 1e-3) to SMu0166, a predicted LraI protein and ABC transporter element.","Sun Oct 27 20:49:31 2002","Thu Sep 7 16:50:42 2006","pdb1PSZA Chain A, Pneumococcal Surface Antigen Psaa 110 3e-025pdb1TOAA Chain A, Periplasmic Zinc Binding Protein Troa From ... 80 8e-016","SMU.1302c","","Residues 12 to 312 (E-value = 2.9e-83) place SMu1189 in the SBP_bac_9 family which is described as Periplasmic solute binding protein family (PF01297)","Thu Feb 28 09:50:42 2002","","","Kitten T, Munro CL, Michalek SM, Macrina FL.Genetic characterization of a Streptococcus mutans LraI family operon and role in virulence.Infect Immun. 2000 Aug;68(8):4441-51.PMID: 10899841","Dintilhac,A. and Claverys,J.P.The adc locus, which affects competence for genetic transformationin Streptococcus pneumoniae, encodes an ABC transporter with aputative lipoprotein homologous to a family of streptococcaladhesinsRes. Microbiol. 148 (2), 119-131 (1997)PubMed: 9765793Dintilhac,A., Alloing,G., Granadel,C. and Claverys,J.P.Competence and virulence of Streptococcus pneumoniae: Adc and PsaAmutants exhibit a requirement for Zn and Mn resulting frominactivation of putative ABC metal permeasesMol. Microbiol. 25 (4), 727-739 (1997)PubMed: 9379902","Thu Oct 17 16:43:40 2002","Thu Feb 28 10:01:04 2002","1","","","SMU.1302c","298" "SMu1190","1229223","1227823","1401","ATGATGACTTGTACAACCATTCTTGTTGGAAAAAAGGCCAGTTATGATGGTTCTACCATTATTGCCAGAACAGAAGATTCACAAAATGGTGTCTTTTGTCCTAAAAAATTTGAAGTGATAAAATCAGAAGCTCAACCAAAGCATTATCGATCGGTTTTATCAAATTTTGAAATAGATTTACCTGATAACCCTTTATCCTATACTTCCGTTCCCAATGCTTTAGACAATGAAGGTATTTGGGCTGAAGCTGGTATTAATGCTGCTAATGTTGCTATGAGTGCCACAGAGACCATCACAACTAATGCACGTGTGTTGGGAGCAGATCCTTTAGTAGCATCAGGTATTGGGGAAGAAGATATGCTGACTTTGGTTTTGCCTTATATTCAGTCAGCGCGTGAGGGTGTTGAGCGTCTGGGCAAACTTCTGGAAGAATATGGTACATATGAATCCAATGGTATAGCTTTTTCAGATATCAATGAAATTTGGTGGTTGGAAACAATTGGAGGACATCATTGGATTGCTCGCCGTGTTCCCGATGATGCTTATGTTACTAATCCTAATCAGTTAGGGATTGATCATTTTGAGTTTAATAATCCCGATGATTATCGCTATTCCAATGATTTAAAAGATTTCATAGCTGACAATCATCTTGATTTGACTTATTCAAATGAGCACTTTAATCCTCGTTATGCTTTTGGCAGTCAAAAAGATAAGGATAGACATTACAATACACCACGTTCTTGGGCTATACAGCGCTTTTTAAATCCAGAAATCGAACAAGATCCACGGAGTTTCTTTATTCCTTGGTGTCAAAAGCCTTATCGCAAGATTACGGTAGAAGACATTAAGTATGTTTTGAGCAATCACTATCAAGATACAAATTTTGATCCTTATGGATCAGAAGGAGACCGCCTTAGTCAAACAACTTTTAGAACCATTGGTATTAATCGAACCAGCCAGACAGCTCTTTTGCAATTACGTCCTAATCAAACACCAGAAACTAGGGGGATTCAATGGCTTTCCTATGGTTCCATGCCTTTTAATACGATGGTGCCTTTCTTTACGCAAGTTTCAAAAACACCAGCCTATTTTGCCAATACCAGTGCAAGGGTGACAACAGATAATTTTTATTGGACTAACCGTTTAATTGCAGCCCTTGCCGATTCACATTATCATAGACACGAAGGAAATTTAGAAGCCTATGTTGAGAAAACAATGGCAGCAGGGCATGCTATGATCCACCGTGTTGATGAAGCTTTAGCAAAAGGAGAAAAAGTTGATTTTGAGGGGGAAAATCAAGCCATGAGTGATTTTATTGAGGAACAGACACAGGTTCTTCTGGAACAAATTCTCTTTGATGCTAGTAATCTGATGACCAATCGCTATGGTGTTAGTGATTAG","4.80","-19.97","53026","MMTCTTILVGKKASYDGSTIIARTEDSQNGVFCPKKFEVIKSEAQPKHYRSVLSNFEIDLPDNPLSYTSVPNALDNEGIWAEAGINAANVAMSATETITTNARVLGADPLVASGIGEEDMLTLVLPYIQSAREGVERLGKLLEEYGTYESNGIAFSDINEIWWLETIGGHHWIARRVPDDAYVTNPNQLGIDHFEFNNPDDYRYSNDLKDFIADNHLDLTYSNEHFNPRYAFGSQKDKDRHYNTPRSWAIQRFLNPEIEQDPRSFFIPWCQKPYRKITVEDIKYVLSNHYQDTNFDPYGSEGDRLSQTTFRTIGINRTSQTALLQLRPNQTPETRGIQWLSYGSMPFNTMVPFFTQVSKTPAYFANTSARVTTDNFYWTNRLIAALADSHYHRHEGNLEAYVEKTMAAGHAMIHRVDEALAKGEKVDFEGENQAMSDFIEEQTQVLLEQILFDASNLMTNRYGVSD","1227838","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). ","dipeptidase","Cytoplasm, Extracellular","Several matches in gapped BLAST to dipeptidase: residues 3-466 are 75% similar to the enzyme in S.pyogenes (gi15674771). Residues 3-457 are 49% similar to the protein from Lactococcus lactis (gi15673540).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0534 (0.0).","

InterPro
IPR005322
Family

Peptidase C69, dipeptidase A
PF03577	$\"[3-404]T$	Peptidase_C69

noIPR
unintegrated

unintegrated
PTHR12994	$\"[129-200]T$	PTHR12994
PTHR12994:SF3	$\"[129-200]T$	PTHR12994:SF3
SSF51658	$\"[165-241]T$	SSF51658

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 357-466 are 27% similar to a (DIPEPTIDASE PROTEOME COMPLETE 3.4.-.-) protein domain (PD184300) which is seen in Q48558_LACHE.Residues 3-354 are 57% similar to a (DIPEPTIDASE PROTEOME COMPLETE CLUSTER) protein domain (PD042986) which is seen in Q9CFC3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 26 16:24:33 2006","Thu Feb 28 10:02:55 2002","Wed Jul 26 16:24:33 2006","Thu Feb 28 10:02:55 2002","","Thu Feb 28 10:02:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1190 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 10:06:07 2002","","No significant hits to the NCBI PDB database.","SMU.1303c","","Residues 3 to 404 (E-value = 8.6e-275) place SMu1190 in the Peptidase_U34 family which is described as Peptidase family U34 (PF03577)","Thu Feb 28 10:02:55 2002","24379719","","","Vesanto,E., Peltoniemi,K., Purtsi,T., Steele,J.L. and Palva,A.Molecular characterization, over-expression and purification of anovel dipeptidase from Lactobacillus helveticusAppl. Microbiol. Biotechnol. 45 (5), 638-645 (1996)PubMed: 8766699Dudley,E.G., Husgen,A.C., He,W. and Steele,J.L.Sequencing, distribution, and inactivation of the dipeptidase Agene (pepDA) from Lactobacillus helveticus CNRZ32J. Bacteriol. 178 (3), 701-704 (1996)PubMed: 8550503","","Thu Feb 28 10:06:07 2002","1","","","SMU.1303c","655" "SMu1191","1230497","1229586","912","ATGAGTTTTACCACACAGGTGAAAGAAGAAATCTTAAATTTGGATTCAGCTGACAAAAATGAATTGTCGGCTATTATTAAAATGTCAGGGAGTTTAGGCTTGGCAGATAAAAAGCTCAGTTTATCCATCATTACTGAAAATGCTAAAATTGCTCGCCATATTTACGCATTATTGGAACGACTCTATCGGATTAATCCTGAGATAAAGTACCATCACAAAACCAACTTGCGAAAAAACCGTGTTTATACTGTTTTTTTAGATGACAATGTTGAACAAATATTAGCCGATTTACAGCTTTCGGATTCTTTTTTTGGAATTGAAACTGGCATTGAACAGCAAATTTTATCTGATGATAATGCTGGCCGTTCTTATTTGAAAGGAGCCTTCCTTTCCACTGGATCCATCCGAGATCCTGAATCGGGCAAATATCAGCTGGAGATTTTCTCTGTTTATCTTGATCATGCTGAAGATTTAGCAAAACTAATGCAAAAGTTTATGTTAGATACCAAGGTGATTGAACATAAGCATGGTGCAGTTACTTATTTGCAAAAAGCAGAAGATATCATGGATTTTCTGATTATTATCGGCAGTATGGAAGGTATGGAAGCTTTTGAAAATATTAAGGTTATGCGCGAAACAAGAAATGATGTCAACCGTACCAGTAATGCCGAAACAGCTAATATTGCTAAGACGATTAATGCTAGTATCAAAACGATTAATAATATCAACAAAATAAAAGAAACTGTTGGTTTGGAAAGTTTGCCTATAGAATTGCAGCGGATTGCCCAAATCAGAGCAGCCCATCCTGACTTTTCTATCCAGCAGATTGCTGATAGCTTAGCTGTACCCTTAACCAAGAGCGGCGTTAATCATAGGTTAAGAAAAATTAATAAAATTGCTGAAGATTTATAA","6.50","-2.05","34178","MSFTTQVKEEILNLDSADKNELSAIIKMSGSLGLADKKLSLSIITENAKIARHIYALLERLYRINPEIKYHHKTNLRKNRVYTVFLDDNVEQILADLQLSDSFFGIETGIEQQILSDDNAGRSYLKGAFLSTGSIRDPESGKYQLEIFSVYLDHAEDLAKLMQKFMLDTKVIEHKHGAVTYLQKAEDIMDFLIIIGSMEGMEAFENIKVMRETRNDVNRTSNAETANIAKTINASIKTINNINKIKETVGLESLPIELQRIAQIRAAHPDFSIQQIADSLAVPLTKSGVNHRLRKINKIAEDL","1229601","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins : residues 1-303 are 71% similar to the protein in S.pyogenes (gi|15674722|) and are 62% similar to the protein from S.pneumoniae (gi|8953584|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0533 (1e-119).","

InterPro
IPR003802
Family

Protein of unknown function DUF199
PF02650	$\"[3-301]T$	DUF199
TIGR00647	$\"[1-301]T$	MG103

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[223-293]T$	Homeodomain_like

noIPR
unintegrated

unintegrated
SSF55608	$\"[110-218]T$	SSF55608
SSF75217	$\"[35-71]T$	SSF75217

","BeTs to 4 clades of COG1481COG name: Uncharacterized BCRFunctional Class: SThe phylogenetic pattern of COG1481 is ------v--br---gp-----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 95-299 are 64% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL MG103) protein domain (PD024150) which is seen in Q9JRK5_BBBBB.Residues 1-94 are 57% similar to a (PROTEOME COMPLETE YJJA ORF314) protein domain (PD337884) which is seen in Q9JRK5_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 10:18:14 2002","Thu Feb 28 10:18:14 2002","Thu Feb 28 10:18:14 2002","Thu Feb 28 10:18:14 2002","","Thu Feb 28 10:18:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1191 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 10:18:14 2002","","No significant hits to the NCBI PDB database.","SMU.1304c","","Residues 3 to 301 (E-value = 2e-72) place SMu1191 in the DUF199 family which is described as Uncharacterized BCR, COG1481 (PF02650)","Thu Feb 28 10:18:14 2002","24379720","","","","","","1","","","SMU.1304c","297" "SMu1192","1231471","1230494","978","ATGAGAAAACCTAAAATAACTGTTATTGGCGGTGGAACTGGGATACCTGTTATTCTCAACAGTCTGCGTCATGAAGAGGTAGATATCACAGCAATCGTTACTGTAGCAGATGATGGCGGCAGTTCTGGTGCTATCCGTCATGTTATGCAATTAACACCTCCAGGAGATCTTAGAAATGTCTTAGTTGCTATGAGTGATATGCCAAAATTTTATGAGAGAATCTTTCAATATCGCTTTAACGCTGAAGACGGGGCATTAGCTGGTCATCCTTTGGGAAATTTAATCATTGCAGGTATTTCTGAGATGCAGGGTTCCACTTACAATGCTATGCAGATATTGTCAAAATTTTTCCATACAACAGGTAAGATTTATCCTTCAAGTGAAAAGGCTTTAACGCTTCATGCTGTTTTTCAGGATGGGCAAGAAGTGGTTGGTGAAAGTCAGATTGCCAAGCATAAAGGAATGATTGATCATGTCTATGTGGCTAATAGCTATGACGATGCTAAGCCGACTGCCAGTCGTAAGGTTGTTGATGCTATTATGGAAAGTGATATGATTGTTCTAGGTCCGGGTTCGCTCTTCACTTCTATTCTCCCAAACTTAGTCATTGATGAAATTGGAAAAGCACTCTGTGAGACCGAGGCAGAAGTAGCCTATGTCTGCAATATTATGACTCAATATGGTGAAACGGAACACTTTACAGATGCTGATCATGTGCGAGTTCTCAATCGTCATTTGGGACAAAACTTTATTGATACCGTTTTGGTTAATGTAGAAAAAGTTCCTCAAGATTATATGAATTCTAATCAATTTGATGAATACCTCATTCAAGTAGAGCATGACTTTGCTGGACTTCAAGAGCAGGTACCCCGAGTGGTTTCTTCTAATTTTCTTTGTTTGGAAAATGGCGGTGCTTTTCACAATGGTAAAAGTGTTGTGGATGAATTGATGAATTTAATCAAGGTGAAAGAGCTATGA","5.00","-14.23","35755","MRKPKITVIGGGTGIPVILNSLRHEEVDITAIVTVADDGGSSGAIRHVMQLTPPGDLRNVLVAMSDMPKFYERIFQYRFNAEDGALAGHPLGNLIIAGISEMQGSTYNAMQILSKFFHTTGKIYPSSEKALTLHAVFQDGQEVVGESQIAKHKGMIDHVYVANSYDDAKPTASRKVVDAIMESDMIVLGPGSLFTSILPNLVIDEIGKALCETEAEVAYVCNIMTQYGETEHFTDADHVRVLNRHLGQNFIDTVLVNVEKVPQDYMNSNQFDEYLIQVEHDFAGLQEQVPRVVSSNFLCLENGGAFHNGKSVVDELMNLIKVKEL","1230509","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical protein: residues 19-322 are 78% similar to the protein in S.pyogenes (gi|15674721|). Residues 19-324 are 76% similar to the protein from S.pneumoniae (gi|15901408|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0532 (1e-137).","

InterPro
IPR002882
Family

Protein of unknown function UPF0052 and CofD
PF01933	$\"[6-301]T$	UPF0052

InterPro
IPR010119
Family

Conserved hypothetical protein, CofD related
TIGR01826	$\"[6-321]T$	CofD_related

","BeTs to 9 clades of COG0391COG name: Uncharacterized ACR, YbhK/UPF0052 familyFunctional Class: SThe phylogenetic pattern of COG0391 is amt-yqvcebr----------Number of proteins in this genome belonging to this COG is 1","***** IPB002882 (Uncharacterised protein family) with a combined E-value of 6.8e-41. IPB002882A 6-43 IPB002882B 114-125 IPB002882C 180-203","Residues 174-210 are 72% similar to a (PROTEOME YJIF 5'REGION COMPLETE) protein domain (PD405409) which is seen in Q9CGY0_LACLA.Residues 25-210 are 38% similar to a (PROTEOME COMPLETE VNG1429C ML0759) protein domain (PD382235) which is seen in Q9X235_THEMA.Residues 215-321 are 77% similar to a (PROTEOME YJIF COMPLETE) protein domain (PD414816) which is seen in Q9JRL1_BBBBB.Residues 19-152 are 78% similar to a (PROTEOME COMPLETE CRH-TRXB VC1023) protein domain (PD006387) which is seen in Q9JRL1_BBBBB.Residues 172-213 are 80% similar to a (PROTEOME COMPLETE CRH-TRXB SLL0154) protein domain (PD383083) which is seen in Q9JRL1_BBBBB.Residues 215-316 are 37% similar to a (PROTEOME COMPLETE CRH-TRXB SLL0154) protein domain (PD014042) which is seen in YVCK_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 10:24:57 2002","Thu Feb 28 10:20:46 2002","Thu Feb 28 10:20:46 2002","Thu Feb 28 10:20:46 2002","Thu Feb 28 10:20:46 2002","Thu Feb 28 10:24:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1192 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 10:24:57 2002","","No significant hits to the NCBI PDB database.","SMU.1305c","","Residues 6 to 301 (E-value = 6.2e-138) place SMu1192 in the UPF0052 family which is described as Uncharacterised protein family UPF0052 (PF01933)","Thu Feb 28 10:20:46 2002","24379721","","","","","","1","","","SMU.1305c","296" "SMu1193","1232358","1231468","891","ATGAGTGAGAAAAAAATTGATTTGGTTATTGTGACCGGTATGAGTGGGGCCGGTAAGACAGTTGCCATTCAGTCTTTTGAAGACTTGGGTTATTTTACCATTGACAATATGCCGCCAGCATTGGTTCCCAAATTTTTGGAATTAGTTGAAAGCAGCGGTGAAAATGATAAAGTGGCTTTGGTAGTTGATATGCGTAGCCGTCTCTTTTTTAAGGAAGTCAGTTCTATTTTAGATAAGATTGACTTAAATGAGACAATTAATTTTCGCATTCTATTTTTGGATGCAACAGATAGCGAATTGGTTTCACGGTATAAGGAAACACGTCGCAGTCATCCTTTGGCTACAACTGGCCGTGTTCTAGATGGAATTGCTCTTGAGAGGGAATTGTTAGCTCCTTTAAAGAATCTCAGCCAAAATGTTGTTGATACGACCGATTTAACACCGCGTCAACTCCGTAAAACCATTTCCGATCAATTTTCTGTTGAGAAGAGTCAAACGAGTTTTCGCTTAGAAGTTGTCAGCTTTGGATTCAAATATGGTTTACCTTTGGATGCAGATCTAGTTTTTGATGTGCGTTTTCTGCCTAATCCGTACTATAAACCAGAACTGCGAGATAAAACAGGACTGGATAAAGATGTCTCGGATTATGTCATGCAGCATCAGGAGTCAGAAGAATTTTATCAACACTTATTGGCTTTGCTAGCGCCTATTTTACCGGGTTATCAAAAGGAAGGGAAATCTGTTCTGACTATTGCTATTGGCTGTACAGGCGGTCAGCACCGCAGTGTAGCTTTTGCTCATCGGCTGGCTCAAGATTTAGGACAAAATTGGACGGTTAATGAGAGCCATCGTGATAAAAATCGGCGTAAAGAGACGGTGAATCGTTCATGA","6.30","-2.58","33486","MSEKKIDLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALVPKFLELVESSGENDKVALVVDMRSRLFFKEVSSILDKIDLNETINFRILFLDATDSELVSRYKETRRSHPLATTGRVLDGIALERELLAPLKNLSQNVVDTTDLTPRQLRKTISDQFSVEKSQTSFRLEVVSFGFKYGLPLDADLVFDVRFLPNPYYKPELRDKTGLDKDVSDYVMQHQESEEFYQHLLALLAPILPGYQKEGKSVLTIAIGCTGGQHRSVAFAHRLAQDLGQNWTVNESHRDKNRRKETVNRS","1231483","","conserved hypothetical protein, ATP-binding domain","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical protein: residues 1-296 are 80% similar to the protein in S.pyogenes (gi15674720) and are 75% similar to the protein from S.pneumoniae (gi15901409). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0531 (1e-139).","

InterPro
IPR005337
Family

P-loop ATPase protein
PIRSF005052	$\"[6-292]T$	P-loopkin
PF03668	$\"[6-289]T$	ATP_bind_2

InterPro
IPR014756
Domain

Immunoglobulin E-set
SSF81296	$\"[234-285]T$	Ig_E-set

noIPR
unintegrated

unintegrated
SSF52540	$\"[5-186]T$	SSF52540

","BeTs to 3 clades of COG1660COG name: Uncharacterized BCR, YhbJ/UPF0042 familyFunctional Class: SThe phylogenetic pattern of COG1660 is --------ebrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 3-263 are 67% similar to a (COMPLETE PROTEOME ATP-BINDING ORF4) protein domain (PD013996) which is seen in Q9CGY1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 16:37:59 2006","Thu Sep 7 16:37:59 2006","Thu Sep 7 16:37:59 2006","Thu Feb 28 10:23:26 2002","","Thu Feb 28 10:23:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1193 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 10:23:26 2002","","No significant hits to the NCBI PDB database.","SMU.1306c","","Residues 6 to 289 (E-value = 1.5e-128) place SMu1193 in the ATP_bind_2 family which is described as P-loop ATPase protein family (PF03668)","Thu Feb 28 10:23:26 2002","24379722","","","","","","1","","","SMU.1306c","295" "SMu1194","1233109","1232351","759","ATGACGACGGTTTTGAATAAGAAACAAACTTATAAAGATATTTTTGATGGCCGCAGTTATCAAAAAGTAGATGGTGCCTTATTTAAAAATTTAGATCAAGGGATTAAAAATGAGTTATTAGAGGATTATCCTAAGCTTAAGGATGATGATTTTATTGCTTATGTGCATTTAACAAAGTATAGTCTTAGATATATGGGTAAAATTATTGTTCGGGCTCAGGAAAAAAATGAGAGCATCAAAGGTTATGTAACAGCTCTCAGTCAGGAAAAAGACAATATTAATGTTGATGAGCAACTGCAGGCAAAGATTACCTTTGGACAAAAAATTGCCGATGCTGTGGCTAAATTTGGCGGTTCTTGGACCTTTATTATTTCTTTTATTTTATTGATGGCAGCTTGGATGCTAATCAATCAGTTGCGACTGTTTGGTCTGCATTTTGATGTCTATCCTTTTATTTTACTCAACCTTGCTCTATCCACTCTAGCAGCAGTGCAGGCTCCGCTCATTATGATGAGTCAAAATCGGGCGGCAGAATATGACCGTTTGCAAGCTTTGAATGATTTTAATGTTAATAAGAAATCTGAAGAAGAAATCCGTTTTCTGCATGCTAAATTGGATCATATTGTTCAGCAAGACCAAAGTGAGCTGTTAGAAATACAAAAACTACAGACAGAAATGCTGGCAGCTATTAGCCGTCAGTTGACACGTTTAGAAAGCATGCAAAATCAAATGGAGGGAGTGAAGGAAGAAAATGAGTGA","5.80","-3.02","29063","MTTVLNKKQTYKDIFDGRSYQKVDGALFKNLDQGIKNELLEDYPKLKDDDFIAYVHLTKYSLRYMGKIIVRAQEKNESIKGYVTALSQEKDNINVDEQLQAKITFGQKIADAVAKFGGSWTFIISFILLMAAWMLINQLRLFGLHFDVYPFILLNLALSTLAAVQAPLIMMSQNRAAEYDRLQALNDFNVNKKSEEEIRFLHAKLDHIVQQDQSELLEIQKLQTEMLAAISRQLTRLESMQNQMEGVKEENE","1232366","","conserved hypothetical protein","Cytoplasm, Membrane","Several matches in gapped BLAST to hypothetical proteins: residues 3-249 are 39% similar to the protein in Lactococcus lactis (gi|15672474|). Residues 17-227 are 36% similar to the protein from Mesorhizobium loti (gi|13474144|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2047 (7e-74).","

InterPro
IPR010406
Family

Protein of unknown function DUF1003
PF06210	$\"[94-224]T$	DUF1003

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 104-187 are 57% similar to a (PROTEOME COMPLETE MEMBRANE INTEGRAL) protein domain (PD178092) which is seen in Q9CI74_LACLA.Residues 188-249 are 38% similar to a (PROTEOME COMPLETE YEJC) protein domain (PD394069) which is seen in Q9CI74_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 10:26:19 2002","Thu Feb 28 10:26:19 2002","Thu Feb 28 10:26:19 2002","Thu Feb 28 10:26:19 2002","","Thu Feb 28 10:26:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1194 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 10:26:19 2002","","No significant hits to the NCBI PDB database.","SMU.1307c","","Residues 94 to 224 (E-value = 3e-83) place SMu1194 in the DUF1003 family which is described as Protein of unknown function (DUF1003) (PF06210)","Thu Feb 28 10:26:19 2002","24379723","","","","","","1","","","SMU.1307c","734" "SMu1195","1233617","1233240","378","ATGAAAAAAATTCATACTGATAAAGCACCCGCAGCAATTGGACCTTATGTTCAAGGAAAAATTGTGGGAAATTTACTTTTTGCTTCTGGTCAGGTTCCCTTGTCACCAGAAACCGGTCAAGTGATTGGGACAACTATTGAAGAACAGACCCAACAGGTCTTAAAAAATATTTCAGCTATTTTAACTGAGGCTGGAACAGACTTTGATCATGTCGTCAAGACAACATGCTTCTTGAGTGATATTGATGATTTTGTCCCTTTTAATGAGGTATATGCAACAGCTTTTAAATCTGATTTTCCAGCGCGTTCAGCCGTTGAAGTGGCGCGTTTGCCCAAAGATGTTAAGATTGAAATTGAGGTTATTGCTGAACTTATTTAA","4.60","-5.57","13544","MKKIHTDKAPAAIGPYVQGKIVGNLLFASGQVPLSPETGQVIGTTIEEQTQQVLKNISAILTEAGTDFDHVVKTTCFLSDIDDFVPFNEVYATAFKSDFPARSAVEVARLPKDVKIEIEVIAELI","1233255","For other 'ald' genes see SMu1321 (aldB), a predicted alpha-acetolactate decarboxylase.","AldR-related regulatory protein: translation initiation inhibitor","Cytoplasm","Several matches in gapped BLAST to regulatory protein AldR: residues 2-124 are 84% similar to the protein in S.pneumoniae (gi15903468). Residues 1-124 are 66% similar to the protein from Lactococcus lactis (gi15673211).SMu1195 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006056
Family

YjgF-like protein
TIGR00004	$\"[1-124]T$	YjgF-like
PS01094	$\"[100-118]T$	UPF0076

InterPro
IPR006175
Domain

Endoribonuclease L-PSP
PF01042	$\"[6-124]T$	Ribonuc_L-PSP

InterPro
IPR013813
Domain

Endoribonuclease L-PSP/chorismate mutase-like
G3DSA:3.30.1330.40	$\"[2-122]T$	Endoribo_LPSP/chorism_mut-like
SSF55298	$\"[1-122]T$	YjgF/chorismate_mutase-like

InterPro
IPR014420
Family

Translation initiation inhibitor, TdcF type
PIRSF004689	$\"[1-125]T$	TdcF

noIPR
unintegrated

unintegrated
PTHR11803	$\"[4-125]T$	PTHR11803

","BeTs to 9 clades of COG0251COG name: Putative translation initiation inhibitorFunctional Class: JThe phylogenetic pattern of COG0251 is ---kYqvCEbRHuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000543 (YER057c/YjgF/UK114 family) with a combined E-value of 7.1e-55. IPB000543A 9-36 IPB000543B 49-95 IPB000543C 100-122","Residues 49-122 are 41% similar to a (PROTEOME COMPLETE PA1568 PM0366) protein domain (PD332122) which is seen in Q9KWS2_PSESP.Residues 88-122 are 71% similar to a (COMPLETE PROTEOME INHIBITOR TRANSLATION INITIATION) protein domain (PD002429) which is seen in Q9KGJ8_BACHD.Residues 39-84 are 65% similar to a (PROTEOME COMPLETE INHIBITOR REGULATOR) protein domain (PD412735) which is seen in ALDR_LACLA.Residues 2-84 are 50% similar to a (INHIBITOR TRANSLATIONAL COMPLETE PROTEOME) protein domain (PD253166) which is seen in HR12_MOUSE.Residues 34-84 are 54% similar to a (PROTEOME COMPLETE INHIBITOR TRANSLATION) protein domain (PD366227) which is seen in Q9PMR2_CAMJE.Residues 2-33 are 68% similar to a (PROTEOME COMPLETE INHIBITOR TRANSLATION) protein domain (PD074584) which is seen in Q9L6B5_PASMU.Residues 1-33 are 75% similar to a (PROTEOME COMPLETE APE1501 VNG2099C) protein domain (PD227488) which is seen in ALDR_LACLA.Residues 22-122 are 31% similar to a (PLASMID) protein domain (PD200009) which is seen in O85956_SPHAR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 12:39:12 2007","Fri Mar 16 12:39:12 2007","Thu Mar 1 11:27:16 2007","Thu Feb 28 10:32:40 2002","Thu Feb 28 10:32:40 2002","Thu Feb 28 10:32:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1195 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 11 10:02:41 2002","Thu Mar 1 11:27:16 2007","pdb1QD9A Chain A, Bacillus Subtilis Yabj >gi6573366pdb1QD9... 137 6e-034pdb1QU9A Chain A, 1.2 A Crystal Structure Of Yjgf Gene Produc... 123 6e-030","SMU.1308c","","Residues 6 to 124 (E-value = 2.2e-60) place SMu1195 in the Ribonuc_L-PSP family which is described as Endoribonuclease L-PSP (PF01042)","Thu Feb 28 10:32:40 2002","","","","Goupil-Feuillerat,N., Cocaign-Bousquet,M., Godon,J.J., Ehrlich,S.D.and Renault,P.Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp. lactisJ. Bacteriol. 179 (20), 6285-6293 (1997)PubMed: 9335274","","Thu Feb 28 10:32:40 2002","1","","","SMU.1308c","" "SMu1196","1234738","1233647","1092","ATGACAACTACTATAATGGCAAGCTATAGTTATGGTGAGGACTGCTATCAAGAAATTCCCGAAGTCTTAAAACCTTATCATATTAAGCGGGTGGTCTTAATTGGGGGAGAGAGAGCCTTGGCCAGCAGTGAGGATGAGGTTCGCAGTATTTTGGTGCAGGCAGGTATCGAAGTGACGGGCAGCTTTGTCTACGGCGTTGATTCGACACAAACAAACATTGATAAACTGGTAGCTAATCCAGATGTACAGAGAGCGGAAGCTATTTTTGGTTTTGGAGGCGGAAAAGCACTTGATACAGCTAAAATGGTTGCTAAAGAATTGGATAAACCTACCTTTACTTTCCCGACAATTTGCTCTAATTGTTCGGCTGGGACAGCGATTGCAGTCGTTTACAATGATGATCATTCTCTTTTAAAATATGGCTATCCTGATTCGCCGCTTCATATTTTTATTAATACGCGTGTTATTGCACAAGCACCTGAGAAGTATTTTTGGGCAGGTATTGGCGATGGTATTTCAAAAGCTCCTGAAGTTGAGCATGCTATCTTGGAAGCAAAGAAAAAAGGGACAGCAGAGTTTCCTCATACCGCAAGATTAGGTGAGGCTGTGGCACTATCTTCAAAAGAGGCCTTTTATCGTTATGGTCAACAAGGGCTGGAAGATGTACGAAATAACAAAGTATCTCGGGCAGTTGAAGAAATTGCACTTGATATTGTGGTATCAACTGGTTATGCTTCTAACTTGGTCAATCAGCCTGATTTTTACTACAACTCTTGTCATGCCCATGCTTTTTATAATGGCACAACTGCCATCAGGCGCGAAGGAGAATACCTTCATGGTATGGTTGTTTCTTATGGTGTGTTAGTCTTGCATGCATATTTTGATGAACAAGAAGAACTGGAACGTGTGGCTAATTTCAACAAGGCATTAGGATTGCCAATCAGATTGCAGGAACTAGGATTGACTAAGGAAGATATTCCTAAAATTGTTGAAGTTGCCTTAACAACTAATGAATACCGCAATACACCTTTTGACCCTGAAAAATTTGCTCAAGCTATCCGTACGGTTGATTATCTCGGTCAGCAATTATAA","5.10","-11.99","40114","MTTTIMASYSYGEDCYQEIPEVLKPYHIKRVVLIGGERALASSEDEVRSILVQAGIEVTGSFVYGVDSTQTNIDKLVANPDVQRAEAIFGFGGGKALDTAKMVAKELDKPTFTFPTICSNCSAGTAIAVVYNDDHSLLKYGYPDSPLHIFINTRVIAQAPEKYFWAGIGDGISKAPEVEHAILEAKKKGTAEFPHTARLGEAVALSSKEAFYRYGQQGLEDVRNNKVSRAVEEIALDIVVSTGYASNLVNQPDFYYNSCHAHAFYNGTTAIRREGEYLHGMVVSYGVLVLHAYFDEQEELERVANFNKALGLPIRLQELGLTKEDIPKIVEVALTTNEYRNTPFDPEKFAQAIRTVDYLGQQL","1233662","For other 'gld' genes see SMu0448 (gldA) ","glycerol dehydrogenase","Cytoplasm","Several matches in gapped BLAST to glycerol dehydrogenase: residues 7-336 are 27% similar to the enzyme in Salmonella typhimurium (gi|16763979|). Residues 7-357 are 26% similar to the enzyme from E.coli (gi|7427673|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2046 (1e-161).","

InterPro
IPR002658
Domain

3-dehydroquinate synthase AroB
PF01761	$\"[12-357]T$	DHQ_synthase

noIPR
unintegrated

unintegrated
G3DSA:1.20.1090.10	$\"[159-362]T$	G3DSA:1.20.1090.10
G3DSA:3.40.50.1970	$\"[9-158]T$	G3DSA:3.40.50.1970
PTHR11496	$\"[125-345]T$	PTHR11496
SSF56796	$\"[1-355]T$	SSF56796

","BeTs to 7 clades of COG0371COG name: Glycerol dehydrogenaseFunctional Class: CThe phylogenetic pattern of COG0371 is amtk--VcEb-----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 63-318 are 29% similar to a (SYNTHASE 3-DEHYDROQUINATE DEHYDROGENASE LYASE PROTEOME) protein domain (PD002227) which is seen in GLDA_BACST.Residues 117-230 are 30% similar to a (OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD414961) which is seen in YBDH_ECOLI.Residues 196-338 are 32% similar to a (GLYCEROL OXIDOREDUCTASE DEHYDROGENASE) protein domain (PD133020) which is seen in Q9WYQ4_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 07:42:15 2002","Thu Feb 28 10:39:23 2002","Fri Oct 18 07:42:15 2002","Thu Feb 28 10:39:23 2002","","Tue Feb 12 12:52:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1196 is paralogously related (blast p-value < 1e-3) to SMu0448, also a predicted glycerol dehydrogenase.","Thu Feb 28 10:39:23 2002","","No significant hits to the NCBI PDB database.","SMU.1309c","","Residues 7 to 353 (E-value = 2.2e-10) place SMu1196 in the Fe-ADH family which is described as Iron-containing alcohol dehydrogenase (PF00465)","Tue Feb 12 12:52:08 2002","24379725","","","Truniger V, Boos W.Mapping and cloning of gldA, the structural gene of the Escherichia coli glycerol dehydrogenase.J Bacteriol. 1994 Mar;176(6):1796-800.PMID: 8132480 ","","Tue Feb 12 12:52:08 2002","1","","","SMU.1309c","" "SMu1197","1234816","1234953","138","ATGATTTTCAAGCTATTTGAAGAGCACCTTTTGTATCTGCTTGATGCTTTTTATTATAGCAAAATATTCAGAAGATTAAAACAAGGACTTTACAGAAGAAAAGAACAGCCTTATACTCAGGACTTGTTTAGAATGTAA","10.60","4.22","5792","MIFKLFEEHLLYLLDAFYYSKIFRRLKQGLYRRKEQPYTQDLFRM","1234962","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.SMu1197 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 10:40:50 2002","Thu Feb 28 10:40:50 2002","Thu Feb 28 10:40:50 2002","Thu Feb 28 10:40:50 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1197 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 10:40:50 2002","","No significant hits to the NCBI PDB database.","SMU.1310","","No significant hits to the Pfam 11.0 database","Thu Feb 28 10:40:50 2002","24379726","","","","","","1","","","SMU.1310","" "SMu1198","1236596","1235250","1347","GTGTCTAAAGACTATATATCTATTATTGATGTGAAAAATCATGTCGGTGAGGAAGTTACTATCGGTGCCTGGGTTGCTAATAAATCAGGCAAAGGGAAAATCGCTTTCTTACAGTTGCGTGATGGAACAGCTTTTTTCCAAGCGGTTGCTTTTAAGCCTAATTTTATCGAAAAATTTGGTGAAGAAGCAGGACTTGAAAAATTCAATACTATTAAACATCTTAATCAAGAAACAGCAATTGAAATTAAGGGAATTGTCAAAGAAGACAAACGTTCGAAATTTGGTTATGAGTTGGATGCGACTGACTTAAAAGTCATTGGGACATCTGACAATTATCCTATTACGCCAAAAGAACATGGAACTGATTTTTTGATGGATCATCGCCACCTTTGGCTGCGCTCACGAAAGCAGATGGCCATTATGCAGATTCGTAATGCTGTCATCTATGCTTCTTATGAGTTTTTTGACCAAAACGGCTTTGTCAAATTTGACAGTCCAATCTTATCGGGCAATGCAGCAGAAAACACAACGGATCTTTTTGAGACAGACTATTTTGGTGAGCCTGCTTTTCTCAGTCAGTCAGGTCAGCTCTATTTGGAAGCAGGTGCTATGGCATTTGGCCGCGTCTTTGATTTCGGACCTGTTTTCCGTGCTGAAAAGTCAAAAACACGCCGCCATTTGACAGAGTTTTGGATGATGGATGCAGAATACCCATTCATGTCGCATGAACAGTCCCTTGATTTGCAAGAAGCTTATGTCAAAACGCTCATTCAGGGTGTTCTTGATCGGGCGCCGCAGGCTCTTGGTATCTTAGAACGCGATACGGATTTACTTAGGAAGTATATTGCCCAACCGTTTAAGCGTGTCTCTTATGATGATGCGATTACACTTCTTCAAGAGCATGAAGAAGATGAGGATACTGATTATGAGCATATTGAGCATGGAGATGATTTTGGATCGCCTCATGAAACTTGGATTTCCAATTACTTTGGAATACCAACTTTTGTTGTCAACTATCCAGCTAGCTTGAAAGCCTTTTACATGAAACCGGTACCGGGCAATCCGGATCGTGTTCTCTGTGCTGATTTGCTTGCTCCGGAGGGTTATGGTGAAATCATTGGCGGCTCTGAGCGTGAAACAGATTATAATACTTTACTTGCGAAAATCAAAGAGAATGGACTTAATCCGGATGATTATGCCTTTTATCTCGACCTGCGTCAATATGGTTCTGTTCCGCACTGTGGGTTCGGTCTTGGTTTGGAGCGTATGGTGACTTTTGTAGCAGGAACGAAACACATCCGTGAAGCCATTCCTTTCCCGCGGATGCTCCATAGAATTGAACCATAG","5.00","-17.67","51005","MSKDYISIIDVKNHVGEEVTIGAWVANKSGKGKIAFLQLRDGTAFFQAVAFKPNFIEKFGEEAGLEKFNTIKHLNQETAIEIKGIVKEDKRSKFGYELDATDLKVIGTSDNYPITPKEHGTDFLMDHRHLWLRSRKQMAIMQIRNAVIYASYEFFDQNGFVKFDSPILSGNAAENTTDLFETDYFGEPAFLSQSGQLYLEAGAMAFGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYPFMSHEQSLDLQEAYVKTLIQGVLDRAPQALGILERDTDLLRKYIAQPFKRVSYDDAITLLQEHEEDEDTDYEHIEHGDDFGSPHETWISNYFGIPTFVVNYPASLKAFYMKPVPGNPDRVLCADLLAPEGYGEIIGGSERETDYNTLLAKIKENGLNPDDYAFYLDLRQYGSVPHCGFGLGLERMVTFVAGTKHIREAIPFPRMLHRIEP","1235265","","asparaginyl-tRNA synthetase","Cytoplasm","Several matches in gapped BLAST to asparaginyl-tRNA synthetase: residues 1-448 are 80% similar to the enzyme in S.pyogenes (gi|15674719|). Residues 6-448 are 77% similar to the protein from S.pneumoniae (gi|15902045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0526 (0.0).","

InterPro
IPR002312
Family

Aspartyl-tRNA synthetase, class IIb
PR01042	$\"[191-203]T$ $\"[207-220]T$ $\"[363-379]T$ $\"[403-417]T$	TRNASYNTHASP

InterPro
IPR004364
Domain

tRNA synthetase, class II (D, K and N)
PF00152	$\"[120-444]T$	tRNA-synt_2

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[19-106]T$	tRNA_anti

InterPro
IPR004522
Family

Asparaginyl-tRNA synthetase, class IIb
TIGR00457	$\"[5-448]T$	asnS: asparaginyl-tRNA synthetase

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[143-438]T$	AA_TRNA_LIGASE_II

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[110-448]T$	no description
PTHR22594	$\"[93-448]T$	ASPARTYL/LYSYL-TRNA SYNTHETASE
PTHR22594:SF6	$\"[93-448]T$	ASPARTYL-TRNA SYNTHETASE

","BeTs to 11 clades of COG0017COG name: Aspartyl/asparaginyl-tRNA synthetasesFunctional Class: JThe phylogenetic pattern of COG0017 is amtKY--ceb-h--gpol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 399-448 are 46% similar to a (SYNTHETASE LIGASE ATP-BINDING ASNRS) protein domain (PD406040) which is seen in SYN_HUMAN.Residues 315-396 are 85% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD110921) which is seen in Q9CEK9_LACLA.Residues 18-130 are 29% similar to a (LIGASE SYNTHETASE BIOSYNTHESIS) protein domain (PD023126) which is seen in Q9KSF9_VIBCH.Residues 135-205 are 83% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD190230) which is seen in Q9CEK9_LACLA.Residues 207-272 are 83% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD000871) which is seen in Q9CEK9_LACLA.Residues 401-446 are 82% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000848) which is seen in Q9CEK9_LACLA.Residues 139-198 are 66% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD330536) which is seen in Q9KC78_BACHD.Residues 7-136 are 61% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD190154) which is seen in SYN_BACSU.Residues 140-200 are 37% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD206445) which is seen in Q9HKS7_THEAC.Residues 7-134 are 75% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD381092) which is seen in Q9CEK9_LACLA.Residues 401-441 are 51% similar to a (LIGASE SYNTHETASE ATP-BINDING ASNRS) protein domain (PD374631) which is seen in SYNM_YEAST.Residues 6-133 are 30% similar to a (SYNTHETASE LIGASE CYTOPLASMIC) protein domain (PD407537) which is seen in SYN_BRUMA.Residues 401-441 are 48% similar to a (SYNTHETASE SYNC2 ASPARAGINYL-TRNA) protein domain (PD411211) which is seen in Q9SRS4_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 12:56:11 2002","Thu Feb 28 10:42:08 2002","Fri Oct 18 07:43:34 2002","Thu Feb 28 10:42:08 2002","","Thu Feb 28 10:42:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1198 is paralogously related (blast p-value < 1e-3) to SMu1660 and SMu1907, both predicted aspartyl-tRNA synthetases, and SMu0701, a predicted lysyl-tRNA synthetase.","Thu Feb 28 12:56:11 2002","Thu Feb 28 10:42:08 2002","pdb|1B8A|A Chain A, Aspartyl-Trna Synthetase >gi|4388837|pdb|1B... 208 9e-055pdb|1EOV|A Chain A, Free Aspartyl-Trna Synthetase (Asprs) (E.C.... 142 7e-035pdb|1ASZ|A Chain A, Aspartyl Trna Synthetase (Asprs) (E.C.6.1.1... 142 7e-035","SMU.1311c","","Residues 19 to 106 (E-value = 1.2e-16) place SMu1198 in the tRNA_anti family which is described as OB-fold nucleic acid binding domain (PF01336)Residues 120 to 444 (E-value = 1.4e-70) place SMu1198 in the tRNA-synt_2 family which is described as tRNA synthetases class II (D, K and N) (PF00152)","Thu Feb 28 10:42:08 2002","","","","","","","1","","","SMU.1311c","67" "SMu1199","1237824","1236643","1182","ATGACTAAATTATCAAGACGCGTTTTAGAAATGGAAGAGTCTGTTACTTTGGCAACAAGTGCTCGCGCTAAAACACTTAAGGCTCAGGGACGAGATGTTTTAGAACTTTCTTTAGGACAGCCTGATTTTGTAACACCTAAGAATATTCAAGAAGCTGCTATGAAATCAATTAGAGATGGACGTGCTTCTTTTTACACAATTGCTTCAGGTCTTCCTGAACTTAAGGATGCCATTAGTCAATATTTTGAAAAATTTTATGGATACTCTGTAGAGCGCAAACAGATTGTGGTTGGCACTGGAGCTAAGTTTATTCTTTATGCTTTGTTTGCAGCTGTTATTAATCCAAAAGATGAGGTGATTATTCCAACTCCATTTTGGGTGTCTTACGCAGATCAGATCAAGATGAATGATGGTGTACCTGTGTTTATCAGGACAAGTGAAGAAAATCATTTTAAAGCAACAGTCGAACAATTGGAAGCTGCAAGAACTAACAAGACCAAAATGATTGTGCTCAATAGTCCATCTAATCCAACAGGAATGATTTACAGTAAGAAAGAATTGGAAGCTATTGGTAATTGGGCTGTTAAGCATGATATCTTGATTTTATCTGATGATATTTATGGCCGTCTGGTTTATAATGGTGCAAGATTTACGCCTATTTCAACAATTTCACAGCCTATTTGCCAGCAAACAATTGTTATTAATGGGGTATCTAAAACCTATTCCATGACAGGCTGGCGTGTTGGCTATGCTGTTGGTGACCCTGAAATTATTGGAGCTATGTCTAAAATTGTTAGCCAAACAACTTCTAATCTAACAACAGCGGCACAATATGCAGCTATCGAAGCTTTAATAGGTAATCAAGATACAGTTGAAGTGATGCGTCAAGCTTTTGAAGAACGCTTGAATACTATTTATCCTTTGTTGGCAAAAGTTCCGGGATTTCATGTTGTTAAGCCAGAAGGTGCCTTCTACTTTTTCCCTAATGTTAAAAAAGCTATGGAAATGAAGGGGTATACCGATGTAACAGAATTTACGACAGCTCTTTTGGAAGAAACAGGTGTCGCTTTGGTAACAGGTGCTGGCTTTGGTGCACCAGAAAATGTTCGTTTGAGTTATGCAACAGATATGGTCACTCTTAAGGAAGCTATCAATCGCATACAAGCTTTTATGGAAAAATAG","7.60","0.70","43489","MTKLSRRVLEMEESVTLATSARAKTLKAQGRDVLELSLGQPDFVTPKNIQEAAMKSIRDGRASFYTIASGLPELKDAISQYFEKFYGYSVERKQIVVGTGAKFILYALFAAVINPKDEVIIPTPFWVSYADQIKMNDGVPVFIRTSEENHFKATVEQLEAARTNKTKMIVLNSPSNPTGMIYSKKELEAIGNWAVKHDILILSDDIYGRLVYNGARFTPISTISQPICQQTIVINGVSKTYSMTGWRVGYAVGDPEIIGAMSKIVSQTTSNLTTAAQYAAIEALIGNQDTVEVMRQAFEERLNTIYPLLAKVPGFHVVKPEGAFYFFPNVKKAMEMKGYTDVTEFTTALLEETGVALVTGAGFGAPENVRLSYATDMVTLKEAINRIQAFMEK","1236658","For other 'asp' genes see SMu1907 (aspS); SMu1660 (aspS) and SMu1667 (aspG).Note tandem repeats at 1236745,1236781.","aspartate aminotransferase","Cytoplasm, Membrane","Several matches in gapped BLAST to aspartate aminotransferase: residues 3-391 are 75% similar to the enzyme in S.pneumoniae (gi|15903442|)and residues 1-392 are 69% similar to the protein from S.pyogenes (gi|15674718|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0525 (1e-170).","

InterPro
IPR001176
Family

1-aminocyclopropane-1-carboxylate synthase
PR00753	$\"[116-137]T$ $\"[163-187]T$ $\"[199-222]T$ $\"[230-254]T$	ACCSYNTHASE

InterPro
IPR004838
Binding_site

Aminotransferases class-I pyridoxal-phosphate-binding site
PS00105	$\"[236-249]T$	AA_TRANSFER_CLASS_1

InterPro
IPR004839
Domain

Aminotransferase, class I and II
PF00155	$\"[31-387]T$	Aminotran_1_2

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[45-287]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[1-393]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[48-393]T$	PTHR11751
PTHR11751:SF35	$\"[48-393]T$	PTHR11751:SF35

","BeTs to 15 clades of COG0436COG name: PLP-dependent aminotransferasesFunctional Class: EThe phylogenetic pattern of COG0436 is AMTKYQVCEBRhUJ---linxNumber of proteins in this genome belonging to this COG is 4","***** IPB001511 (Aminotransferases class-I) with a combined E-value of 6.7e-17. IPB001511A 65-75 IPB001511B 169-183 IPB001511C 236-249","Residues 105-207 are 68% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9R6Q3_BBBBB.Residues 15-100 are 33% similar to a (PROTEOME COMPLETE) protein domain (PD090141) which is seen in P96847_MYCTU.Residues 13-49 are 72% similar to a (AMINOTRANSFERASE ASPARTATE COMPLETE) protein domain (PD021714) which is seen in Q9R6Q3_BBBBB.Residues 61-357 are 22% similar to a (Y4RO ERYTHROCYTE HEMOLYSIN PLASMID) protein domain (PD040058) which is seen in O68622_PREIN.Residues 322-388 are 74% similar to a (AMINOTRANSFERASE ASPARTATE PROTEOME COMPLETE PYRIDOXAL) protein domain (PD000894) which is seen in Q9R6Q3_BBBBB.Residues 14-390 are 19% similar to a (METHYLTRANSFERASE S-METHYLTRANSFERASE) protein domain (PD329530) which is seen in Q9LTB2_ARATH.Residues 319-392 are 40% similar to a (AMINOTRANSFERASE PROTEOME COMPLETE) protein domain (PD164903) which is seen in Q9ZLG5_HELPJ.Residues 198-328 are 25% similar to a (PROTEOME COMPLETE AMINOTRANSFERASE) protein domain (PD356437) which is seen in Q9KAU1_BACHD.Residues 99-216 are 28% similar to a (AMINOTRANSFERASE TRANSAMINASE ALANINE) protein domain (PD358273) which is seen in Q9N8G6_EEEEE.Residues 298-390 are 36% similar to a (AMINOTRANSFERASE PROTEOME COMPLETE) protein domain (PD093784) which is seen in O30304_ARCFU.Residues 51-103 are 49% similar to a (AMINOTRANSFERASE ASPARTATE PROTEOME) protein domain (PD252868) which is seen in Q9CEK7_LACLA.Residues 210-283 are 72% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL ASPARTATE COMPLETE) protein domain (PD188985) which is seen in Q9CEK7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 30 11:26:34 2002","Thu Feb 28 12:59:31 2002","Fri Oct 18 07:44:25 2002","Thu Feb 28 12:59:31 2002","Thu Feb 28 12:59:31 2002","Thu Feb 28 12:59:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1199 is paralogously related (blast p-value < 1e-3) to SMu0020, SMu1663, SMu1526, SMu0740, SMu1165, SMu0582, and SMu0865, predicted aminotransferases.","Thu Feb 28 13:03:04 2002","Thu Feb 28 12:59:31 2002","pdb|1BKG|A Chain A, Aspartate Aminotransferase From Thermus The... 277 2e-075pdb|1BJW|A Chain A, Aspartate Aminotransferase From Thermus The... 275 8e-075pdb|1BW0|B Chain B, Crystal Structure Of Tyrosine Aminotransfer... 120 2e-028","SMU.1312c","","Residues 84 to 391 (E-value = 4.1e-71) place SMu1199 in the Aminotran_1_2 family which is described as Aminotransferase class I and II (PF00155)","Thu Feb 28 12:59:31 2002","","","","Sung,M.H., Tanizawa,K., Tanaka,H., Kuramitsu,S., Kagamiyama,H.,Hirotsu,K., Okamoto,A., Higuchi,T. and Soda,K.Thermostable aspartate aminotransferase from a thermophilicBacillus species. Gene cloning, sequence determination, andpreliminary x-ray characterizationJ. Biol. Chem. 266 (4), 2567-2572 (1991)PubMed: 1990006","","Thu Feb 28 13:01:38 2002","1","","","SMU.1312c","294" "SMu1200","1240352","1237890","2463","ATGACGGAGAAAAAAACAAGAAAGTATGCTGTGGTTGATTTGGAGGCAACAGGTGCTAGCCACTCAGCTTCCATCATTCAAGTTGGGATTGTGATTATTGAAAATGAACAAATTATTCAAACTTATACCACGGATGTCAATCCCCATAAGCCGCTTTCTAAAGCTATTATTAGATTGACAGGAATTACAGATGCTCAATTGCAGCAGGCGCCTGATTTTTCCGAAGTAGCAGCTGACATCTATCATCTCATTGATGATTGTGTTTTTGTTGCTCACAATGTTAAATTTGATGCCAATCTTTTGGCAGAACATCTTTTTTTAGAAGGATTTGAGCTGCTAACACCTCGTGTTGATACGGTTGAATTGGCACAAGTTTTTTACCCAACTTTTGAAAAATATTCATTAGGAAATTTGACAGAGCTTTTAAAGATTGACTTGTCAGATGCTCATACGGCCATTGCCGATGCGAAAGCAACAGCAGAACTTTTTTTGAAATTAAAACAGAAAATGACAGATCTTCCTAAGTTGACTTTAGAAAGAATCTTGCAATTCTCAGACAGTCTTCTGTATGAATCCAAATTACCTATTGAAGAAGCTTTTGCAGCAGCTTCCAATCACTTGTCATCAGATTATCAGGAAGTGGCAGGAATTGTCCTAAAAAAAGAAGAGCCTTTTTTAAAAGAACGGCAGTTATCACAGGATTTTGCGACTAATATCGCCTTGTTAGACCTTGAAGAAAGAACTCAGCAGCTTAAATTTGCCCAAGTTATTGAAGCGAAATTTGAAGATAGTAGGGCTAGTTTTATTGAGGCTCAATCAGGCATTGGTAAAACCTATGGTTACCTCTTACCACTTCTTAATCAGCATGGGGAGGAACAGATTATCGTCAGTGTTTCAACCAAAATTCTTCAAGATCAAATCATGGCTAATGAGGCACAGGCTTTAAGAGAAGCTTTTCATATCAATAGTCACAGCTTAAAGAGTCCTCAAAATTACCTCAAATTAGATAGCTTTTATAAGACTTTGATGAGAAAAGATGATAATCGTTTGCTCAATCGTTATAAGATGCAGCTTTTGGTTTGGTTGTTGGAAACAAGAACTGGCGATCTTGATGAGATCAAACAAAAACAACGCTATGCTGCTTATTTTGACGAAATCAGACATGATGGCACTTTGAGTAAGCAATCCCTTTTTTATCATCTTGATTTCTGGCAGAAAAGTTATCAAAGAGCAAAATCAAGCCGTTTGCTTATTACTAATCACGCCTATCTCTTAACGCGTATAGAAGATGATCAGGCCTTTGTTGAAAATCAGATTTTGGTTATTGATGAGGCGCAGAGACTTTTTTTGACCTTGGAGCAGTTTTCAAGGCGCCAAATCAACATGACTGAGACTTTACAGACTCTTAATCAGCTTTTGGAGAATTCTCAAAATATTTTAGAAAAACGGTTGTTAGAAAGCATTCAGTTTGAATTAAATCATTTGTTATATCTTTTTAATAAGGAAAAGCGACAGTTATTTAAGAAAGAAACTATTGAACGCTTGCGGCAACATTTATCAGAATTAAGTCTGACCGAGTTAGCGGATTTACAGGCTTTATTTGAAGAACCTTATTCAGACTTTTGGTTTGAAGAAGATTTCTTTTGGGATCATCGAACAGTTCTTCTAAAGTCAGCCCGTCTTGATTTTACTGACTTTACACAATTTTTACCGGCTACCAAAAAGACTTACTTGGTTTCAGCCACTCTTCAAATTAGTCCCAAAGTGAGTTTAGCGAACCTTCTTGGCTTTGAACAGTTTACTTTTGATAGTATTTCGGGAGAAAAGTCACATCAGCAGGCTATTTGGGTTGATAAGACAATGCCTAGAGTAAATGATATATCAGATTCAGAGTATGAAACATTGCTTACCAAACGGCTGTTGCAATTGGCTCAGCTAAAGCAGCCCATGTTGGTTCTTTTTAACTCTAAAAAAACGATGTTTGCTGTTTCTGATTTGCTGGATGAAGCGAAACTTACTCATTTGACTCAGGAGAAAAATGGAAGTCCCTTTAATATTAAGCGGCGTTTTGATCGTGGAGAAGCTGATATATTGCTTGGAACAGGAGGTTTTTGGGAAGGTGTTGATTTTGTTGAGCAAGACCGCTTAATTGAGGTCATCACGCGTTTGCCGTTTGATAATCCGGAGGATTTGTTTGTTAAGAAATTAAATCGTCAATTACGGCAGGAAGGTAAAAATCCTTTTTATGACTATACTTTACCAACAAGCATTTTACGCTTGCGACAGGCTATTGGCCGAACAAGGCGCAATAACAGGCAGTTTTCAGCAATTGTTATTTTAGATAGCCGAGTTGTCAATAAAAACTATGGAAAAATAATTTATCAGGCTCTAGCTAGTCATTTCTCCGTTTCGAGTCAACATTTTCAGAAGATTCTCGTTGAAGTGACTCATTTTTTGATATAA","6.10","-10.89","95025","MTEKKTRKYAVVDLEATGASHSASIIQVGIVIIENEQIIQTYTTDVNPHKPLSKAIIRLTGITDAQLQQAPDFSEVAADIYHLIDDCVFVAHNVKFDANLLAEHLFLEGFELLTPRVDTVELAQVFYPTFEKYSLGNLTELLKIDLSDAHTAIADAKATAELFLKLKQKMTDLPKLTLERILQFSDSLLYESKLPIEEAFAAASNHLSSDYQEVAGIVLKKEEPFLKERQLSQDFATNIALLDLEERTQQLKFAQVIEAKFEDSRASFIEAQSGIGKTYGYLLPLLNQHGEEQIIVSVSTKILQDQIMANEAQALREAFHINSHSLKSPQNYLKLDSFYKTLMRKDDNRLLNRYKMQLLVWLLETRTGDLDEIKQKQRYAAYFDEIRHDGTLSKQSLFYHLDFWQKSYQRAKSSRLLITNHAYLLTRIEDDQAFVENQILVIDEAQRLFLTLEQFSRRQINMTETLQTLNQLLENSQNILEKRLLESIQFELNHLLYLFNKEKRQLFKKETIERLRQHLSELSLTELADLQALFEEPYSDFWFEEDFFWDHRTVLLKSARLDFTDFTQFLPATKKTYLVSATLQISPKVSLANLLGFEQFTFDSISGEKSHQQAIWVDKTMPRVNDISDSEYETLLTKRLLQLAQLKQPMLVLFNSKKTMFAVSDLLDEAKLTHLTQEKNGSPFNIKRRFDRGEADILLGTGGFWEGVDFVEQDRLIEVITRLPFDNPEDLFVKKLNRQLRQEGKNPFYDYTLPTSILRLRQAIGRTRRNNRQFSAIVILDSRVVNKNYGKIIYQALASHFSVSSQHFQKILVEVTHFLI","1237905","For other 'din' genes see SMu0109 (dinF) and SMu0364 (dinP). ","ATP-dependent DNA helicase","Cytoplasm","Several matches in gapped BLAST to ATP-dependent DNA helicase: residues 1-820 are 53% similar to the enzyme in S.pyogenes (gi|15674717|). Residues 8-805 are 46% similar to the protein from S.pneumoniae (gi|15900695|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0524 (0.0).","

InterPro
IPR001650
Domain

Helicase, C-terminal
PS51194	$\"[635-809]T$	HELICASE_CTER

InterPro
IPR006054
Domain

DNA polymerase III, epsilon subunit
TIGR00573	$\"[1-210]T$	dnaq

InterPro
IPR006055
Domain

Exonuclease
SM00479	$\"[8-172]T$	EXOIII

InterPro
IPR006310
Family

DnaQ exonuclease/DinG helicase
TIGR01407	$\"[8-819]T$	dinG_rel

InterPro
IPR006555
Domain

Helicase c2
SM00491	$\"[650-786]T$	HELICc2

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[6-191]T$	RNaseH_fold

InterPro
IPR013520
Domain

Exonuclease, RNase T and DNA polymerase III
PF00929	$\"[9-163]T$	Exonuc_X-T

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[242-506]T$	DEXDc

InterPro
IPR014013
Domain

Helicase superfamily 1 and 2 ATP-binding, DinG/Rad3-type
PS51193	$\"[236-494]T$	HELICASE_ATP_BIND_2

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[258-484]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.10	$\"[2-174]T$	G3DSA:3.30.420.10

","BeTs to 6 clades of COG0847COG name: DNA polymerase III epsilon subunit (3'-5' exonuclease)Functional Class: LThe phylogenetic pattern of COG0847 is a---YQvcEbRHuj---lINxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 86-147 are 55% similar to a (DNA POLYMERASE III EPSILON) protein domain (PD006730) which is seen in Q9CEK5_LACLA.Residues 8-84 are 55% similar to a (DNA POLYMERASE III COMPLETE) protein domain (PD002851) which is seen in Q9CEK5_LACLA.Residues 745-789 are 53% similar to a (HELICASE ATP-DEPENDENT PROTEOME) protein domain (PD018408) which is seen in Q9CEK5_LACLA.Residues 327-445 are 36% similar to a (HELICASE ATP-DEPENDENT ATP-BINDING DNA) protein domain (PD329182) which is seen in DING_BACSU.Residues 624-729 are 41% similar to a (HELICASE ATP-DEPENDENT DING DNA) protein domain (PD414953) which is seen in Q9CEK5_LACLA.Residues 88-145 are 50% similar to a (DNA POLYMERASE III REPLICATION) protein domain (PD369841) which is seen in Q9KC83_BACHD.Residues 235-319 are 43% similar to a (HELICASE ATP-BINDING DNA ATP-DEPENDENT PROTEOME COMPLETE) protein domain (PD009997) which is seen in Q9CEK5_LACLA.Residues 330-615 are 31% similar to a (HELICASE PROTEOME COMPLETE ATP-DEPENDENT) protein domain (PD401240) which is seen in Q9CEK5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 12:08:28 2002","Thu Feb 28 13:09:00 2002","Fri Oct 18 07:46:48 2002","Thu Oct 24 12:08:28 2002","","Thu Feb 28 13:09:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1200 is paralogously related (blast p-value < 1e-3) to SMu0110, a predicted DNA polymerase III, alpha subunit.","Thu Feb 28 13:10:05 2002","","No significant hits to the NCBI PDB database.","SMU.1313c","","Residues 9 to 163 (E-value = 3e-34) place SMu1200 in the Exonuc_X-T family which is described as Exonuclease (PF00929)","Thu Feb 28 13:09:00 2002","24379729","","","","","Thu Oct 24 12:08:28 2002","1","","","SMU.1313c","66" "SMu1201","1240761","1241444","684","ATGCACGATGGGCAAAATATTTTTTACAGTAAGGAATCCTTTTCAGGCTACTCTTGGAAAATTATTCCGACCATCAAACAACACAAGGAATTGCCTAAGTTAATTATTGTTGGTATTGACAATTCCGGTGACAACCGCCTCAATGAATATGCTCCTTGGATGACCGATGTTGGAACGACACCTGAAACTGCCAGCAGTGGTGGAGATGGTATGGCTTATGGTGAATGGGTTGTTAATACTGTTAAACCCTTTATTGACCAAACCTATCGTAGCAAGACTGATCCTGCCAATACGCTCTTAGCTGGATCTTCCATGGGTGGTATCATTACGGCCTATATGGGAGCTGCCTATCCTCATATTTTTGGAAATCTCGGCGTTTTTTCTCTAGCCTCTTGGTTCAGCGAACGCGATTTCCTTCGTTTCTTGAATCACCATCCTCTGGATAAAAACAGCAAGGTCTTTATCCAAGTTGGTACCAAAGAAGGTGATGCTGTTGACGATGAATTTGCTCCTAATATGAATCAGGCCTATATTGACTGTACGCTCCACTACTATCAGTCCCTCCTACGCACTGGTCATCCTATGGAGCATATTGATTTACATATCATGGCCAACGAAATTCATCACGAAAAATATTGGGCTAATCATTTTATTGAATTTCTGAAATTCACATTGAAAGGATAA","6.20","-5.16","25700","MHDGQNIFYSKESFSGYSWKIIPTIKQHKELPKLIIVGIDNSGDNRLNEYAPWMTDVGTTPETASSGGDGMAYGEWVVNTVKPFIDQTYRSKTDPANTLLAGSSMGGIITAYMGAAYPHIFGNLGVFSLASWFSERDFLRFLNHHPLDKNSKVFIQVGTKEGDAVDDEFAPNMNQAYIDCTLHYYQSLLRTGHPMEHIDLHIMANEIHHEKYWANHFIEFLKFTLKG","1241453","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 2-223 are 43% similar to S.pyogenes (gi|15900765|) and residues 2-227 are 31% similar to Deinococcus radiodurans (gi|15805805|).SMu1201 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000801
Family

Putative esterase
PF00756	$\"[1-224]T$	Esterase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[1-223]T$	G3DSA:3.40.50.1820
PTHR10907	$\"[19-166]T$	PTHR10907
SSF53474	$\"[1-226]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 72-225 are 30% similar to a (ESTERASE PROTEOME COMPLETE TRANSPORT) protein domain (PD018028) which is seen in Q9RW90_DEIRA.Residues 100-223 are 25% similar to a (PROTEOME COMPLETE RRNG-FEUC YBBA) protein domain (PD079609) which is seen in Q9S6X7_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 13:17:27 2002","Thu Feb 28 13:17:27 2002","Thu Feb 28 13:17:27 2002","Thu Feb 28 13:17:27 2002","","Thu Feb 28 13:17:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1201 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 13:17:27 2002","","No significant hits to the NCBI PDB database.","SMU.1314","","No significant hits to the Pfam 11.0 database","Thu Feb 28 13:17:27 2002","24379730","","","","","","1","","","SMU.1314","" "SMu1202","1242309","1241656","654","ATGCAGATCAAAGATTTTAATTTAAAAATAAATCAGCAGTTATTATTGGATAATGTCAGTATGTCCTTTGCCAATCAAAAATTAAATCTTATTATCGGTAGAAATGGTGTAGGAAAGACACTGTTATTGGATTTAATTTCTGACTTAGACCATAATAGACCTGAAAATTTTCACGATTTTCCTAAGAATAGTCGAATTATTTATCATAGTCAAGGCTTACCCTTTATTGCAGAGGCCACTGTAAAAGATACAATAACTTTAATTGGAGATTTGTCCGAGGATAGTGCTATCACAATGGAGCACCTTCCTCAAAAAATTAGAAATAATTTGAATAAACCTTTTGGTTCCTTGTCTATGGGAGAGCGCAGGTATTTGACCATCTGGTTATTTTTGCAAATCGAAAGAGACTTATATATTTTCGACGAACCGTTTGCTAATTTGGATCTCAGTGTTATCTCTGATATCTTGAGTCTCTTTTATGATAAACTTGATCAAGGAAAGCAGTTAATCATCACCTCTCATCAATTTGACTTTTTGGTTCCTGAAAAAACACAAATCATTTTTATTGAGGACAAACAAATCAAATTTAATGATAGTCTTACAGCTTTTTTAGCCTATTATCATTCATTTGGTCAAGCTTTTGATATACAATAG","5.10","-6.56","25102","MQIKDFNLKINQQLLLDNVSMSFANQKLNLIIGRNGVGKTLLLDLISDLDHNRPENFHDFPKNSRIIYHSQGLPFIAEATVKDTITLIGDLSEDSAITMEHLPQKIRNNLNKPFGSLSMGERRYLTIWLFLQIERDLYIFDEPFANLDLSVISDILSLFYDKLDQGKQLIITSHQFDFLVPEKTQIIFIEDKQIKFNDSLTAFLAYYHSFGQAFDIQ","1241671","For other components see SMu1203 (MSD1). ","ABC transporter, ATP-binding protein","Cytoplasm","This sequence corresponds to the previously sequenced gi|5918764| in GenBank, predicted MutT from S.mutansMatches in gapped BLAST to ABC transporter (ATP-binding protein) : residues 1-199 are 26% similar to gi|15926900| from S.aureus.Residues 1-195 are 23% similar to gi|16804811| from Listeria monocytogenes The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2027 (1e-08).","

InterPro
IPR003439
Domain

ABC transporter related
PF00005	$\"[25-192]T$	ABC_tran
PS50893	$\"[1-216]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[25-200]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-207]T$	G3DSA:3.40.50.300
PTHR19222	$\"[1-204]T$	PTHR19222
PTHR19222:SF4	$\"[1-204]T$	PTHR19222:SF4
SSF52540	$\"[3-202]T$	SSF52540

","BeTs to 6 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.6e-07. IPB001140A 15-61 IPB001140B 114-152 IPB001140C 169-198","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:14:57 2002","Thu Feb 28 13:25:44 2002","Fri Oct 18 14:38:49 2002","Thu Feb 28 13:21:11 2002","Thu Feb 28 13:21:11 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1202 is paralogously related (blast p-value < 1e-3) to SMu0849, SMu1068, SMu1001, SMu1093, SMu1023, SMu0731, SMu1410, SMu1288, SMu0944, SMu0218, SMu0164, SMu1920, SMu1380, SMu0517, SMu0418, SMu0390, SMu0374, SMu1751, SMu1757, SMu0823, SMu0825, SMu1949, SMu0916, SMu0976, SMu1064, SMu0752, SMu1079, SMu1959, SMu1037, SMu0884, SMu0596, SMu0476, SMu0666, SMu1517, SMu1316, SMu0729, SMu0235, SMu0907, SMu0986, and SMu1545, all ATP-binding proteins.","Thu Feb 28 13:25:44 2002","","No significant hits to the NCBI PDB database.","SMU.1315c","","Residues 25 to 192 (E-value = 4.3e-13) place SMu1202 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Feb 28 13:21:11 2002","24379731","","","","","","1","","","SMU.1315c","" "SMu1203","1243042","1242311","732","ATGTTAAAGAAAATACTGGCACTGTTTAAATTTCAGATAAATATAACTCTGTCCAATAAATTCTTTTTGGTTTATACCCTGCTTTTACCAGCTGTCAATTTGTTTTTAGCTTTAAGCAAAAGAGGAATCGGCTTAGATGCTCAAGAGAAATTTGTCTTTTTGACTCCCTATATTTCTTATATTATTGTTATTGCCATGTTATTTGGCTGGGCAGGAAATATTGTTTCTCTTAGAGAAAATAACTATCTCAAAGTTTTTTCTAGTCTAACGGGTTCAAAATTTTATATTTTTGCTGTTAATTTATTAGTCAATTTTCTTTTAACAAGCGTACAAATTAATATTCTGCTCTTTATTTTTGAATTAATAACTAAAAGTGTTGATTTAGAATTATTTGTGTTTTTTAATATTTTAACCTTTTTAGGAGTAGCAATTTGTTTTTTTGCTTTTGCTATCTTTTTAAAGCTTTCTGTAAATGCAGTAACCTTGCAGGCTATCTTAACATCTTATTTGTTGCTTTCTTTGCTATCATTGGAGTATACGTCTAAAAATATTATTTTAAGTGGCTTGTTTCATTTTATGAATATTTTTTCTTTGGTTAATGAAATTAGCTTAACTATAAGTGGTAAGCTTGTGGATGCAGCTCCTTTATACCTGCCAATATTTGCTTGGCTTATTGTGGGCAGTTACTGTCTGAAAGAGTCATCGGTATTTTCCATAAAAGATAGGAATTAA","10.00","6.13","27447","MLKKILALFKFQINITLSNKFFLVYTLLLPAVNLFLALSKRGIGLDAQEKFVFLTPYISYIIVIAMLFGWAGNIVSLRENNYLKVFSSLTGSKFYIFAVNLLVNFLLTSVQINILLFIFELITKSVDLELFVFFNILTFLGVAICFFAFAIFLKLSVNAVTLQAILTSYLLLSLLSLEYTSKNIILSGLFHFMNIFSLVNEISLTISGKLVDAAPLYLPIFAWLIVGSYCLKESSVFSIKDRN","1242326","For other components see SMu1202 (NBD1).","hypothetical protein ","Membrane, Cytoplasm","This is a potential ABC transporter membrane spanning permease.No significant hits in gapped BLAST found.SMu1203 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[31-204]T$	no description

noIPR
unintegrated

unintegrated
signalp	$\"[1-34]?$	signal-peptide
tmhmm	$\"[21-39]?$ $\"[53-73]?$ $\"[94-114]?$ $\"[133-153]?$ $\"[155-177]?$ $\"[183-203]?$ $\"[213-231]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[7-225]T$	G3DSA:3.40.50.1820
PTHR10907	$\"[74-134]T$	PTHR10907
PTHR10907:SF3	$\"[74-134]T$	PTHR10907:SF3
SSF53474	$\"[1-230]T$	SSF53474

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[121-312]T$	ATP_GRASP

InterPro
IPR013650
Domain

ATP-grasp fold, succinyl-CoA synthetase-type
PF08442	$\"[121-157]T$	ATP-grasp_2

InterPro
IPR013815
Domain

ATP-grasp fold, subdomain 1
G3DSA:3.30.1490.20	$\"[129-195]T$	ATP_grasp_subdomain_1

noIPR
unintegrated

unintegrated
PTHR23047	$\"[114-248]T$	PTHR23047
SSF56059	$\"[116-330]T$	SSF56059

","BeTs to 5 clades of COG0439COG name: Biotin carboxylaseFunctional Class: IThe phylogenetic pattern of COG0439 is amt-YQ-CeBRhuj----inxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 117-213 are 32% similar to a (LIGASE SYNTHETASE CARBOXYLASE COMPLETE PROTEOME) protein domain (PD000180) which is seen in O67483_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 14:05:20 2002","Thu Feb 28 14:05:20 2002","Thu Feb 28 14:05:20 2002","Thu Feb 28 14:05:20 2002","","Thu Feb 28 14:05:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1206 is paralogously related (blast p-value < 1e-3) to SMu0784, a predicted carbamoyl-phosphate synthase, large subunit and SMu0044 a predicted phosphoribosylamine-glycine ligase.","Thu Feb 28 14:05:20 2002","","No significant hits to the NCBI PDB database.","SMU.1321c","","No significant hits to the Pfam 11.0 database","Thu Feb 28 14:05:20 2002","24379735","","","","","","1","","","SMU.1321c","" "SMu1207","1247118","1246354","765","ATGACAAAAGTTGCAATTGTTACTGGTGCAGGTCAGGGAATTGGCCTTGCTATTGCTAAACGTCTTCATGCCGATGGTTTTAAAATTGGCATGCTTGATTACAATACTCAAGCAGTTCAAGAAGCTGCTGCTAGTATTTCCAAGGAAGATGCCCTAGCAGTAACAGTAGATGTTTCAAAACGTGAGGCTGTTTTTGATGCTTTTGATCAAATTGTTAAAAAATTTGGAGATTTGTCAGTTGTGGTCAACAATGCAGGCCTTGGACCAACGACTCCAGTTGAAACAATTACTGAAGAACAATTTAAACAGGTCTACGGTGTTAATGTCGGAGGTGTCATTTGGGGAACGCAAGCTGCTTATAAGCATTTTAAAGCTTTGGGACATGGCGGAAAGATTATCAATGCCAGTTCACAAGCTGGGGTTGTCGGAAATCCAGAGTTGACACTCTATTCAGGAACTAAATTTGCTGTACGCGGAATCACTCAGGTAACAGCGCGTGACTTAGCTAAAGATGGCATTACAGTTAATGCTTTTGCGCCTGGTATTGTTAAAACACCGATGATGTATGATATTGCTCATAAGGTCGGTCAAAATGCTGGAAAAGATGATGAGTGGGGCATGCAACAATTTGCCAAAGACATCACTTTGCAGCGTTTATCAAAACCAGAAGATGTTGCCAATGTCGTTTCTTTCTTGGCTAGCCCTGATTCAGATTATGTTACTGGTCAAACTATATTGGTTGATGGTGGCATGCAGTTTCATTAA","6.40","-1.80","26889","MTKVAIVTGAGQGIGLAIAKRLHADGFKIGMLDYNTQAVQEAAASISKEDALAVTVDVSKREAVFDAFDQIVKKFGDLSVVVNNAGLGPTTPVETITEEQFKQVYGVNVGGVIWGTQAAYKHFKALGHGGKIINASSQAGVVGNPELTLYSGTKFAVRGITQVTARDLAKDGITVNAFAPGIVKTPMMYDIAHKVGQNAGKDDEWGMQQFAKDITLQRLSKPEDVANVVSFLASPDSDYVTGQTILVDGGMQFH","1246369","For other 'srl' genes see SMu0278 (srlD); SMu0280 (srlM); SMu0281 (srlA); SMu0282 (srlE) and SMu0283 (srlB).","acetoin reductase","Cytoplasm","Several matches in gapped BLAST to acetoin reductase:residues 1-254 are 70% similar to gi15672880 from Lactococcus lactis. Residues 3-253 are 62% similar to gi15923116 from S.aureus The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0523 (1e-112).","

InterPro
IPR002198
Family

Short-chain dehydrogenase/reductase SDR
PR00080	$\"[76-87]T$ $\"[130-138]T$ $\"[150-169]T$	SDRFAMILY
PTHR19410	$\"[3-249]T$	ADH_short_C2
PF00106	$\"[3-169]T$	adh_short
PS00061	$\"[137-165]?$	ADH_SHORT

InterPro
IPR002347
Family

Glucose/ribitol dehydrogenase
PR00081	$\"[4-21]T$ $\"[76-87]T$ $\"[124-140]T$ $\"[150-169]T$ $\"[171-188]T$ $\"[215-235]T$	GDHRDH

InterPro
IPR014007
Family

Acetoin reductase
TIGR02415	$\"[3-254]T$	23BDH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[2-254]T$	G3DSA:3.40.50.720
PTHR19410:SF95	$\"[3-249]T$	PTHR19410:SF95
SSF51735	$\"[1-251]T$	SSF51735

","BeTs to 12 clades of COG1028COG name: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)Functional Class: RThe phylogenetic pattern of COG1028 is a--KYQVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 4","***** IPB002198 (Short-chain dehydrogenase/reductase (SDR) superfamily) with a combined E-value of 5.1e-10. IPB002198 130-165","Residues 54-124 are 60% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME) protein domain (PD126102) which is seen in Q9CH41_LACLA.Residues 175-251 are 83% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD000197) which is seen in Q9CH41_LACLA.Residues 5-173 are 26% similar to a (OXIDOREDUCTASE R119.3) protein domain (PD260605) which is seen in O61709_CAEEL.Residues 127-173 are 78% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD003795) which is seen in Q9CH41_LACLA.Residues 3-48 are 58% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME) protein domain (PD058480) which is seen in Q9CH41_LACLA.Residues 3-153 are 28% similar to a (OXIDOREDUCTASE FLAGELLIN MODIFICATION) protein domain (PD356435) which is seen in Q9PMW7_CAMJE.Residues 3-119 are 29% similar to a (PROTEOME CHAIN COMPLETE SHORT) protein domain (PD295418) which is seen in Q9I715_PSEAE.Residues 7-137 are 34% similar to a (COMPLETE PROTEOME 4-EPIMERASE REDUCTASE UDP-GLUCOSE NAD) protein domain (PD000038) which is seen in Q9X890_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 11:19:54 2006","Thu Feb 28 14:19:58 2002","Thu Sep 7 11:19:54 2006","Thu Feb 28 14:19:58 2002","Thu Feb 28 14:19:58 2002","Thu Feb 28 14:19:58 2002","no","Fri Oct 18 14:38:04 2002","SMu1207 is paralogously related (blast p-value < 1e-3) to SMu1586, a predicted 3-oxoacyl-acyl-carrier-protein; SMu0278, a predicted sorbitol-6-phosphate 2-dehydrogenase; SMu1919,a predicted oxidoreductase (probable short-chain dehydrogenase); SMu0949 and SMu1340, both predicted oxidoreductases; and SMu0339, a predicted oxidoreductase / dehydrogenase.","Thu Feb 28 14:19:58 2002","Thu Sep 7 11:19:54 2006","pdb1YBVA Chain A, Structure Of Trihydroxynaphthalene Reductas... 141 8e-035pdb1EDOA Chain A, The X-Ray Structure Of Beta-Keto Acyl Carri... 122 5e-029pdb1I01A Chain A, Crystal Structure Of Beta-Ketoacyl [acyl Ca... 118 9e-028","SMU.1322c","","Residues 5 to 251 (E-value = 6.2e-81) place SMu1207 in the adh_short family which is described as short chain dehydrogenase (PF00106)","Thu Feb 28 14:19:58 2002","","","","","Tue Apr 2 17:55:04 2002","","1","","","SMU.1322c","908" "SMu1208","1247243","1247881","639","ATGAAAATCTTAAGAACTTTAAACGATGCTGCTCGTGAAAACACCTATTACCTTGTTAATGAAGAGGCAGTCCTCTTGATAGACCCTGGAAGCAATGGTGATGATATCCTTGCTCAATTAAAGGAAATCAATAAACCTATTGCTGCTATTTTACTGACCCATACCCATTACGACCACATTATGAGTCTTGATTTGGTACGGCAGCATTTTAATTATCCGCCAGTCTATGTTTCTGAAAAAGAGGCTTCTTGGCTGGGCAGCCCTATTGACAATTTATCAGGATTGAGTCGTCACAGTGATATGGAAGATGTGGTTGCTGCTCCTGCTGACTTTTTCTTTAATGATAATATGGATTACCATATAGCTGGCTTTCATTTCAAAGTTGTTCCAACACCCGGACATTCTTGGGGAAGTGTTTCCTTTATTTTTATAGATGAAGAAATAGTTTTTTCGGGAGATGCTCTCTTTAAAGAAAGTATTGGGCGTACAGATTTGCCTACTGGAAATTTTGATGAGCTCATTAACAGTATCAAAGAAAACCTTTTTAGCCTGCCAAATCATTTTAAAGTTTTCCCAGGGCATGGCTTTGATACAACAATTGGGCATGAAAAGAACTTCAACCCTTTCTTTAACCAGTAA","4.80","-13.35","23943","MKILRTLNDAARENTYYLVNEEAVLLIDPGSNGDDILAQLKEINKPIAAILLTHTHYDHIMSLDLVRQHFNYPPVYVSEKEASWLGSPIDNLSGLSRHSDMEDVVAAPADFFFNDNMDYHIAGFHFKVVPTPGHSWGSVSFIFIDEEIVFSGDALFKESIGRTDLPTGNFDELINSIKENLFSLPNHFKVFPGHGFDTTIGHEKNFNPFFNQ","1247890","","conserved hypothetical protein (possible hydrolase)","Cytoplasm","Residues 14-69 are 33% similar to previously published CovX from S.mutans gi|14600273|.Matches in gapped BLAST to conserved hypothetical protein:residues 1-211 are 64% similar to gi|15674716| from S.pyogenes and residues 1-210 are 59% similar to gi|15903533| from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0522 (4e-84).","

InterPro
IPR001279
Domain

Beta-lactamase-like
PF00753	$\"[12-194]T$	Lactamase_B

noIPR
unintegrated

unintegrated
PD177909	$\"[1-207]T$	PD177909
G3DSA:3.60.15.10	$\"[3-210]T$	G3DSA:3.60.15.10
PTHR11935	$\"[110-212]T$	PTHR11935
PTHR11935:SF8	$\"[110-212]T$	PTHR11935:SF8
SSF56281	$\"[1-211]T$	SSF56281

","BeTs to 12 clades of COG0491COG name: Zn-dependent hydrolases, including glyoxylasesFunctional Class: RThe phylogenetic pattern of COG0491 is AMtKYQVCEBRHuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB001587 (Uncharacterized protein family UPF0036) with a combined E-value of 3.6e-06. IPB001587B 30-78","Residues 14-81 are 48% similar to a (COMPLETE PROTEOME HYDROLASE FACTOR POLYADENYLATION) protein domain (PD000482) which is seen in Q9CI24_LACLA.Residues 159-209 are 52% similar to a (AQ_2135 ZINC HYDROLASE) protein domain (PD384102) which is seen in YL35_AQUAE.Residues 149-203 are 63% similar to a (HYDROLASE COMPLETE PROTEOME ZINC) protein domain (PD328215) which is seen in Q9CI24_LACLA.Residues 106-204 are 35% similar to a (PROTEOME COMPLETE HYDROLASE) protein domain (PD407524) which is seen in Q9PPB1_CAMJE.Residues 14-82 are 38% similar to a (PROTEOME COMPLETE BH1837) protein domain (PD308148) which is seen in O34910_BACSU.Residues 158-210 are 58% similar to a (PROTEOME COMPLETE HYDROLASE II) protein domain (PD394562) which is seen in Q9JWG2_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 14:26:40 2002","Fri Jan 3 15:36:01 2003","Fri Jan 3 15:36:01 2003","Thu Feb 28 14:24:52 2002","Thu Feb 28 14:24:52 2002","Thu Feb 28 14:24:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1208 is paralogously related (blast p-value < 1e-3) to SMu1377, a predicted CovX protein.","Thu Feb 28 14:26:40 2002","","No significant hits to the NCBI PDB database.","SMU.1323","","Residues 12 to 194 (E-value = 6.2e-35) place SMu1208 in the Lactamase_B family which is described as Metallo-beta-lactamase superfamily (PF00753)","Thu Feb 28 14:24:52 2002","24379737","","","","","","1","","","SMU.1323","654" "SMu1209","1248939","1248004","936","ATGATTAGAAGATTTTTCCGTCATTTATGGCAATCCATTAAAAATTTAAAACGTAATGGCTGGATGACTGTTGCAGCGGTTAGCTCTGTAACTATTACCTTGATCTTGGTCGGTATCTTTGCAGCCTTTCTCTTAAATACTGAAAAGTTAGCATCTGGTATTGAAAAAAATGTTCAGATTAATACTTATTTGCAAGTTGATTCTAAGGATAATGTTAAATCTTATGTAGATTCAAATGATGCCAATAAAACAGTTAACAATCCTGATTATCATAAGGTATATGATCAAATTAAAAAAATTGAACACGTTAAATCAATTACCTTTTCAAGTAAGGATGAACAATTAGAGAAACTTAAGAAAACCATGGGAGACGATTGGAACTTGTTTGATGGGGATTCCAATCCTTTATATGATGTATACATTGTGCAGACAACTTCACCTAGTGAAGTCAAAACAGTAGCTAAAGCTATTGGGAAAATTTCTGGTGTTGATTCAGTTGCTTATGGCGGCACAGATACTGATCGTATTTTTGGTTTGGCTAACTTTGTTCGGACATGGGGACTTGCAGGAACTGGCCTCCTAGTTTTGGTTGCTATCTTTTTGATTTCCAATACGATTCGTATAACTATTTTGTCACGTCGTAATGAAATTCAAATCATGCGTTTAGTTGGTGCCAAAAATGGCTATATCAGAACGCCATTCTTCTTTGAAGGAGCTTGGGTTGGTCTTATTGGAGCGATTATTCCAGCGGTTGTTGTAGGTTACTTATATATCTTTGCATTTGAGCAATTCAATCCAAATCTTGCTGCTCAAAATCTCTCTCTTTATGAACCAAGTCCTTTCATCTTTTACCTTATTGGTGCCATGTTTATCGTTGGTATTTTGATTGGGGCTTTAGGCTCAATTTTATCAATGAGACGATTCTTGAAGATATAA","10.30","8.72","34758","MIRRFFRHLWQSIKNLKRNGWMTVAAVSSVTITLILVGIFAAFLLNTEKLASGIEKNVQINTYLQVDSKDNVKSYVDSNDANKTVNNPDYHKVYDQIKKIEHVKSITFSSKDEQLEKLKKTMGDDWNLFDGDSNPLYDVYIVQTTSPSEVKTVAKAIGKISGVDSVAYGGTDTDRIFGLANFVRTWGLAGTGLLVLVAIFLISNTIRITILSRRNEIQIMRLVGAKNGYIRTPFFFEGAWVGLIGAIIPAVVVGYLYIFAFEQFNPNLAAQNLSLYEPSPFIFYLIGAMFIVGILIGALGSILSMRRFLKI","1248019","For other components see SMu1210 (NBD1)For other 'fts' genes, see SMu0013 (ftsH); SMu0501 (ftsA);SMu0502(ftsZ);SMu0500 (ftsQ); SMu0650 (ftsW); SMu0676 (ftsY); SMu0411 (ftsL); SMu1210 (ftsE) and SMu1483 (ftsK). ","cell division ABC transporter, permease","Membrane, Cytoplasm, Extracellular","Several matches in gapped BLAST to cell division ABC transporter, permease protein: residues 1-310 are 56% similar to the protein in S.pyogenes (gi15674715). Residues 1-311 are 55% similar to the protein from Lactococcus lactis (gi15672955).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0520 (6e-83).","

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[137-309]T$	FtsX

","BeTs to 3 clades of COG2177COG name: Cell division protein FtsXFunctional Class: DThe phylogenetic pattern of COG2177 is --------ebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB003838 (DUF214) with a combined E-value of 7.3e-11. IPB003838A 202-249","Residues 106-246 are 31% similar to a (CELL DIVISION PROTEOME COMPLETE) protein domain (PD011562) which is seen in Q9K1R2_NEIMB.Residues 176-231 are 62% similar to a (PROTEOME COMPLETE MEMBRANE TRANSMEMBRANE) protein domain (PD003665) which is seen in Q9CGW9_LACLA.Residues 233-311 are 53% similar to a (CELL DIVISION PROTEOME COMPLETE) protein domain (PD261437) which is seen in Q9CGW9_LACLA.Residues 106-246 are 31% similar to a (PROTEOME COMPLETE MEMBRANE FTSX) protein domain (PD123909) which is seen in Q9JWT0_NEIMA.Residues 25-311 are 20% similar to a (FTSX) protein domain (PD318129) which is seen in Q9RB39_CYTJO.Residues 1-169 are 56% similar to a (CELL DIVISION PROTEOME COMPLETE) protein domain (PD179467) which is seen in Q9CGW9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 26 16:14:59 2006","Wed Jul 26 16:14:59 2006","Wed Jul 26 16:14:59 2006","Thu Feb 28 14:34:53 2002","Thu Feb 28 14:34:53 2002","Thu Feb 28 14:34:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1209 is paralogously related (blast p-value < 1e-3) to SMu1067, a predicted ABC transporter permease protein.","Thu Feb 28 14:38:43 2002","","No significant hits to the NCBI PDB database.","SMU.1324c","","Residues 137 to 309 (E-value = 2.8e-29) place SMu1209 in the FtsX family which is described as Predicted permease (PF02687)","Thu Feb 28 14:34:53 2002","","","","Scheffers DJ, de Wit JG, den Blaauwen T, Driessen AJ.GTP hydrolysis of cell division protein FtsZ: evidence that the active site is formed by the association of monomers.Biochemistry. 2002 Jan 15;41(2):521-9.PMID: 11781090 Scheffers D, Driessen AJ.The polymerization mechanism of the bacterial cell division protein FtsZ.FEBS Lett. 2001 Sep 28;506(1):6-10. Review.PMID: 11591361 ","","Thu Feb 28 14:38:43 2002","1","","","SMU.1324c","653" "SMu1210","1249624","1248932","693","ATGGCATTAATTCAAATGAAGGGTGTTACGAAAAAATATAACCGCGGTGTAACTGCTCTGCGAAATATAACAATTTCAGTTAATCAAGGTGAATTTGTTTATTTAGTTGGTCCATCAGGTGCTGGAAAGTCAACCTTTATTAGATTGCTTTATCGTGAAGAAAGAACGACTAAAGGGGCTCTTAAAGTTGGGAAATTTAATTTAGCTAAGATGAAGAAAAGAGAAATTCCCATCCTGCGTCGTAGTATTGGGGTTGTCTTCCAAGATTATAAACTCTTGCCTAACAAAACGGTCTTTGAAAATATTGCTTTTGCCATGGAAGTTATCGGTGAAAAACCGCGTGTTATTAAAAAGCGTGTAACAGAAGTTCTTGATTTAGTCGGGCTGAAACACAAAATGCGCTCTTTTCCAGATCAATTATCAGGTGGTGAACAGCAACGGGTGGCAATCGCACGTGCCATTGTCAATAATCCGCAGGTTTTGATTGCCGATGAACCTACAGGTAACTTGGATCCTGAAATTTCATGGGAAATTATGCAGTTGCTTGAACGTATTAATCTTCAAGGGACGACTGTTTTGATGGCAACTCATAATCGCCAAATTGTAGATACACTTCGTCATCGTGTTGTTGCCATTGAAGATGGTCGTATTGTTCGTGATGAAGAGGAAGGAGAGTATGGATATAATGATTAG","10.50","9.73","26045","MALIQMKGVTKKYNRGVTALRNITISVNQGEFVYLVGPSGAGKSTFIRLLYREERTTKGALKVGKFNLAKMKKREIPILRRSIGVVFQDYKLLPNKTVFENIAFAMEVIGEKPRVIKKRVTEVLDLVGLKHKMRSFPDQLSGGEQQRVAIARAIVNNPQVLIADEPTGNLDPEISWEIMQLLERINLQGTTVLMATHNRQIVDTLRHRVVAIEDGRIVRDEEEGEYGYND","1248947","For other components see SMu1209 (MSD1).For other 'fts' genes, see SMu0013 (ftsH); SMu0501 (ftsA);SMu0502(ftsZ);SMu0500 (ftsQ); SMu0650 (ftsW); SMu0676 (ftsY); SMu0411 (ftsL); SMu1209 (ftsX) and SMu1483 (ftsK).For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762(atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).","cell-division ABC transporter, ATP-binding protein","Membrane, Cytoplasm","Matches in gapped BLAST to cell-division ATP-binding protein : residues 15-220 are 38% similar to the previously published protein AtmD in S.mutans (gi15625431). Residues 1-230 are 82% similar to cell-division ATP-binding protein in S.pyogenes (gi15674714) and are 74% similar to gi15900650 from S.pneumoniaeThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0519 (1e-105).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[139-182]T$	ABC_transporter
PF00005	$\"[30-215]T$	ABC_tran
PS00211	$\"[140-154]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-230]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[29-223]T$	AAA

InterPro
IPR005286
Family

Cell division ATP-binding protein FtsE
TIGR02673	$\"[3-216]T$	FtsE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-229]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-225]T$	PTHR19222
PTHR19222:SF36	$\"[4-225]T$	PTHR19222:SF36
SSF52540	$\"[3-226]T$	SSF52540

","BeTs to 4 clades of COG1135COG name: Uncharacterized ABC-type transport system ATPase component/cell division protein FtsEFunctional Class: D,RThe phylogenetic pattern of COG1135 is -------cEBrHuj---l-n-Number of proteins in this genome belonging to this COG is 2","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.6e-33. IPB001140A 19-65 IPB001140B 137-175 IPB001140C 191-220","Residues 183-229 are 78% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD019005) which is seen in Q9CGX0_LACLA.Residues 73-137 are 38% similar to a (ATP-BINDING PROTEOME COMPLETE TRANSPORTER) protein domain (PD406711) which is seen in Q9ZL95_HELPJ.Residues 80-131 are 48% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9RU44_DEIRA.Residues 140-226 are 33% similar to a (ABC TRANSPORTER) protein domain (PD058053) which is seen in O69995_STRCO.Residues 23-107 are 30% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD220985) which is seen in Q9KFD1_BACHD.Residues 69-137 are 34% similar to a (ATP-BINDING TRANSPORT PROTEOME SYSTEM) protein domain (PD239735) which is seen in Q9PPE5_CAMJE.Residues 73-103 are 70% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230) which is seen in O34814_BACSU.Residues 25-71 are 57% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9K6X2_BACHD.Residues 139-182 are 79% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O34814_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 16:34:29 2006","Thu Sep 7 16:34:29 2006","Thu Sep 7 16:34:29 2006","Thu Feb 28 15:38:46 2002","Thu Feb 28 15:38:46 2002","Thu Feb 28 15:38:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1210 is paralogously related (blast p-value < 1e-3) to SMu0786, SMu1762, SMu1751, SMu1288, SMu1380, SMu1246, SMu1231, SMu0517, SMu1068, SMu0731, SMu0849, SMu0418, SMu0884, SMu0916, SMu0218, SMu1428, SMu0805, SMu1003, SMu0971, SMu0594, SMu1079, SMu1949, SMu1920, SMu1950, SMu1518, SMu0235, SMu1001, SMu0335, SMu1757, SMu1649, SMu1316, SMu0390, SMu0950, SMu1517, SMu0596, SMu1036, SMu0234, SMu0216, SMu1037, SMu0825, SMu1023, SMu1545, SMu1410, SMu0907, SMu0374, SMu0986, SMu0476, SMu1064, SMu0944, SMu1065, SMu1710, SMu0976, SMu0258, SMu0837, SMu0475, SMu1306, SMu0987, SMu0836, SMu1724, SMu0824, SMu1093, SMu1050, SMu0666, SMu1959, SMu0224, SMu0024, SMu0823, SMu0752, SMu1811, SMu0164, SMu0729, SMu1686, and SMu1639 all with ATP-binding capabilities.","Wed Apr 3 08:41:24 2002","Thu Sep 7 16:34:29 2006","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 140 2e-034pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 128 6e-031","SMU.1325c","","Residues 30 to 215 (E-value = 1.3e-65) place SMu1210 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Feb 28 15:38:46 2002","","","","","Thu Sep 7 16:34:29 2006","","1","","","SMU.1325c","293" "SMu1211","1250623","1249646","978","ATGACAGAACCAGACTTCTGGGATGACAATATTGCTGCCCAAAAGACATCACAAGAGTTAAACGAACTTAAGCTCAAATATGAAACCTTCAACAGCATGCAGGAACTGTCGGATGAGACAGAATTGTTGCAAGAAATGTTAGAAGAAGATGATAGTTTGCAAGGCGAACTTGAAGAAGACCTTGTCAAGCTTGATAAGATTATGACCAGTTATGAGATGACGCTTCTTTTATCAGAACCCTATGATGCTAACAATGCTATTTTGGAGATCCATCCGGGTTCTGGCGGTACAGAAGCCCAAGACTGGGGTGATATGCTGCTGAGAATGTATACCCGCTTTGGGAATGCCAAGGGGTTCAAAGTAGACGTTTTGGATTATCAAGCTGGTGATGAGGCTGGTATTAAATCAGTCGCTTTATCTTTTGAAGGCCAAAATGCTTATGGTCTTTTAAAATCAGAAATGGGTGTTCACCGTTTGGTCAGAATCTCACCATTTGATTCAGCCAAACGTCGCCACACTTCCTTTGCCTCTGTTGAGGTCATGCCAGAGCTTGATGATACCATAGAAGTAGATATTAGAGATGAAGATATCAAGATGGATACTTTCCGTTCTGGTGGTGCTGGCGGACAAAATGTGAATAAAGTGTCAACTGGAGTTCGCTTAACCCATATTCCTAGCGGCATTGTTGTTGCTTCGACGGTAGATCGTACCCAATATGGAAATCGCGATCGAGCCATGAAAATGCTTCAGGCTAAACTTTATCAAATGGAGCAGGAAAAAAAGGCTCAAGAAGTGGATGCTCTCAAAGGTGACAAAAAGGAAATCACTTGGGGCAGTCAAATTCGTTCTTATGTTTTCACCCCTTATACTATGGTGAAAGATCATCGGACAAACTATGAAGTTTCTCAGGTAGATAGGGTCATGGATGGTGAACTAGATGGTTTTATTGACGCCTTTCTCAAATGGCGTATGGAATAA","4.40","-22.75","36940","MTEPDFWDDNIAAQKTSQELNELKLKYETFNSMQELSDETELLQEMLEEDDSLQGELEEDLVKLDKIMTSYEMTLLLSEPYDANNAILEIHPGSGGTEAQDWGDMLLRMYTRFGNAKGFKVDVLDYQAGDEAGIKSVALSFEGQNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFASVEVMPELDDTIEVDIRDEDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPSGIVVASTVDRTQYGNRDRAMKMLQAKLYQMEQEKKAQEVDALKGDKKEITWGSQIRSYVFTPYTMVKDHRTNYEVSQVDRVMDGELDGFIDAFLKWRME","1249661","For other 'prf' genes see SMu0554 (prfC) and SMu0933 (prfA).","peptide chain release factor","Cytoplasm","Several matches in gapped BLAST to peptide chain release factor 2: residues 1-325 are 89% similar to the enzyme in S.pyogenes (gi15674713) and 85% similar to the protein from S.pneumoniae (gi15902709).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1077 (3e-48).","

InterPro
IPR000352
Domain

Class I peptide chain release factor
PF00472	$\"[183-296]T$	RF-1
PS00745	$\"[203-219]T$	RF_PROK_I

InterPro
IPR004374
Family

Peptide chain release factor 2
PIRSF500106	$\"[1-325]T$	PrfB
PTHR11075:SF6	$\"[1-325]T$	PrfB
TIGR00020	$\"[1-324]T$	prfB

InterPro
IPR005139
Domain

PCRF
PF03462	$\"[45-153]T$	PCRF

InterPro
IPR012086
Family

Protein chain release factor, RF-1/RF-2
PIRSF003056	$\"[1-325]T$	Release_factor

noIPR
unintegrated

unintegrated
PTHR11075	$\"[1-325]T$	PTHR11075
SSF75620	$\"[1-324]T$	SSF75620

","BeTs to 11 clades of COG1186COG name: Protein chain release factor BFunctional Class: JThe phylogenetic pattern of COG1186 is -----qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000352 (Class I peptide chain release factor) with a combined E-value of 2.1e-105. IPB000352A 79-125 IPB000352B 132-183 IPB000352C 196-242 IPB000352D 282-309","Residues 155-238 are 88% similar to a (PEPTIDE FACTOR RELEASE CHAIN BIOSYNTHESIS RF-1 RF-2) protein domain (PD002273) which is seen in Q9CGX1_LACLA.Residues 155-182 are 85% similar to a (PEPTIDE FACTOR RELEASE CHAIN) protein domain (PD253052) which is seen in RF2_THEMA.Residues 41-153 are 61% similar to a (PEPTIDE FACTOR RELEASE CHAIN BIOSYNTHESIS RF-1 RF-2) protein domain (PD088320) which is seen in Q9CGX1_LACLA.Residues 155-323 are 26% similar to a (DOMAIN OF UNKNO N) protein domain (PD399013) which is seen in Q9M2M8_ARATH.Residues 241-320 are 67% similar to a (FACTOR RELEASE CHAIN PEPTIDE) protein domain (PD337383) which is seen in Q9CGX1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 16:16:09 2006","Thu Sep 7 16:16:09 2006","Thu Sep 7 16:16:09 2006","Thu Feb 28 15:50:48 2002","Thu Feb 28 15:50:48 2002","Thu Feb 28 15:50:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1211 is paralogously related (blast p-value < 1e-3) to SMu0993, a predicted peptide chain release factor 1.","Thu Feb 28 16:24:15 2002","","No significant hits to the NCBI PDB database.","SMU.1326c","","Residues 45 to 153 (E-value = 1.6e-53) place SMu1211 in the PCRF family which is described as PCRF domain (PF03462)Residues 185 to 296 (E-value = 2.2e-61) place SMu1211 in the RF-1 family which is described as Peptidyl-tRNA hydrolase domain (PF00472)","Thu Sep 7 16:16:09 2006","","","","Pel,H.J., Rep,M. and Grivell,L.A.Sequence comparison of new prokaryotic and mitochondrial members of the polypeptide chain release factor family predicts a five-domain model for release factor structure.Nucleic Acids Res. 20 (17), 4423-4428 (1992)PubMed: 1408743","","Thu Feb 28 15:51:10 2002","1","","","SMU.1326c","292" "SMu1212","1251912","1250791","1122","ATGATTAAGGAAGCAATCAAACAATTAGCTCAAGATATTGGGATTTCAAAAATAGGATTTACAACAGCTGATGATTTTGATTATTTAGAAAAATCATTACGTGCTTCTGTTGAAGAAGGGCGTTCTTCAGGTTTTGAACATAAAAATATTGAAGAGCGCATCAAGCCCAGACTTTCTTTAGCTAGTGCTAAAACCATTATTTCAATAGCAATTGCTTATCCCCATAAATTGCCTGTTAAACCACCTAAAACTCAGTATAAACGCGGCAAAATTACGCCAAATTCTTGGGGCTTGGACTATCATTATGTTTTGGAGGAAAAATTACAGCGTTTGGCGCAGGGTATTGAAAGTTTATGTCAAGATTTTCCTTTAGAGCATAAAATTATGGTAGATACGGGTGCTTTGGTTGATACAGCCGTTGCCCAGCGCTCTGGAATAGGTTTTATTGGCAAGAATGGCTTAGTCATCTCAAAAGAGTTTGGCTCTTACATGTACTTAGGTGAACTTATTACGAATTTAGAAATTGAGCCTGACAGTCCTGTTGATTATGATTGCGGTGATTGTCACAGATGCTTAGATGCTTGTCCGACTTCCTGTCTTCTTGGTGACGGCAGTATGAATGCTAAGCGCTGTCTTTCCTTTCAAACGCAGGATAAGGGCATGATGGACTTAGAATTTCGTAAAAAAATCAAAACTGTTATTTATGGCTGCGATATTTGCCAAATTTGCTGTCCTTACAATAAAGGAATTCATAATCCTTTGGCCAGTGAAATCGATCCTGAACTTGCAGAGCCGGAACTGCTGCCGTTTTTAGAACTGTCTAATAGTCAATTTAAGAAAAAATTTGGTATGATTGCTGGTTCTTGGCGGGGAAAAAATACTTTACAGCGCAATGCCATTATTGCCCTAGCTAATGGTCATGATAAAAGTGCTCTTGTAAAACTTATGGAAATCATTGACAAGAATAACAATCCCATTCATACTGCAACAGCTATCTGGGCTTTGGGTGAAATTGTTAAAAAGCCAACTCAAGAATTGTATGATTTCATTTTAAGCATTCATTCAGATAATGATGCTATTATAAAAGAGCGAACTGCTCTGCTTAATAGATGGCAATTTTAA","6.90","-0.33","41757","MIKEAIKQLAQDIGISKIGFTTADDFDYLEKSLRASVEEGRSSGFEHKNIEERIKPRLSLASAKTIISIAIAYPHKLPVKPPKTQYKRGKITPNSWGLDYHYVLEEKLQRLAQGIESLCQDFPLEHKIMVDTGALVDTAVAQRSGIGFIGKNGLVISKEFGSYMYLGELITNLEIEPDSPVDYDCGDCHRCLDACPTSCLLGDGSMNAKRCLSFQTQDKGMMDLEFRKKIKTVIYGCDICQICCPYNKGIHNPLASEIDPELAEPELLPFLELSNSQFKKKFGMIAGSWRGKNTLQRNAIIALANGHDKSALVKLMEIIDKNNNPIHTATAIWALGEIVKKPTQELYDFILSIHSDNDAIIKERTALLNRWQF","1250806","","conserved hypothetical protein, 4Fe-4S binding domain","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein:residues2-373 are 72% similar to gi15674712 from S.pyogenes.Residues 2-359 are 43% similar to gi16077956 from B.subtilis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0517 (1e-163).","

InterPro
IPR001450
Domain

4Fe-4S ferredoxin, iron-sulfur binding
PF00037	$\"[179-201]T$	Fer4
PS00198	$\"[185-196]?$	4FE4S_FERREDOXIN

InterPro
IPR009051
Domain

Alpha-helical ferredoxin
SSF46548	$\"[141-247]T$	Helical_ferredxn

InterPro
IPR013542
Domain

Domain of unknown function DUF1730
PF08331	$\"[53-132]T$	DUF1730

noIPR
unintegrated

unintegrated
SSF48371	$\"[295-368]T$	SSF48371

","BeTs to 5 clades of COG1600COG name: Uncharacterized Fe-S proteinFunctional Class: CThe phylogenetic pattern of COG1600 is a-t----ceb-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 135-248 are 39% similar to a (PROTEOME COMPLETE IRON-SULFUR) protein domain (PD013736) which is seen in Q9KV16_VIBCH.Residues 204-359 are 42% similar to a (PROTEOME COMPLETE BH1020) protein domain (PD116734) which is seen in P97030_BACSU.Residues 132-249 are 28% similar to a (PROTEOME COMPLETE IRON-SULFUR) protein domain (PD105297) which is seen in O26323_METTH.Residues 2-111 are 40% similar to a (PROTEOME COMPLETE BH1020) protein domain (PD355665) which is seen in P97030_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 16:28:59 2002","Thu Sep 7 16:07:50 2006","Thu Sep 7 16:07:50 2006","Thu Feb 28 16:26:07 2002","","Thu Feb 28 16:26:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1212 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 16:26:07 2002","","No significant hits to the NCBI PDB database.","SMU.1327c","","No significant hits to the Pfam 11.0 database","Thu Feb 28 16:26:07 2002","24379741","","","","","","1","","","SMU.1327c","291" "SMu1213","1253145","1252672","474","GTGCAACTGATTCGCCAAGCTATGAACAAGCAACTATTACCTGATACTATCGTCATCATGGACAGTTTTCCTTTAGTTCTTTGTCAGTCTGTTCGCAACTGTAGAGCAAGAATTTTTGAAGGGTTAGCAGACATTGGTTACAATGCGTCTAAGCACTTATGGTTCTACGGTTTCAAAGTTCACATGCTCGTTACCTTATCTGGCTCCATTCTGAACGATGTTGTTACGTCAGCATCTGTTCCTGATATCAAAGTGGTAGATGACTTATTGGAAGGTTGCCAGCAATCTGTGATTTTAGCAGACTTAGGCTATCTCAGTCAGGAGCTCAAAGATAGCTTGGAACGAAGAGGGTATCGCTTATGGACACCACGGCGTCAAAACATGGAAGGGGCTAGCCAGCATAACAATTGGAGATTGCTAGCTATGAGACGAACTGTTGAAACACGTTTTTCTGAATTATGTACTTCTGTTTGA","8.20","2.52","17915","MQLIRQAMNKQLLPDTIVIMDSFPLVLCQSVRNCRARIFEGLADIGYNASKHLWFYGFKVHMLVTLSGSILNDVVTSASVPDIKVVDDLLEGCQQSVILADLGYLSQELKDSLERRGYRLWTPRRQNMEGASQHNNWRLLAMRRTVETRFSELCTSV","1252687","","transposase fragment","Cytoplasm","Matches in gapped BLAST to transposase:residues 4-155 are 57% similar to the previously published transposase in S.mutans (gi13897502). Residues 1-154 are 77% similar to transposase in S.criceti (gi15383627) SMu1213 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002559
Domain

Transposase, IS4-like
PF01609	$\"[17-157]T$	Transposase_11

noIPR
unintegrated

unintegrated
signalp	$\"[1-28]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 20-155 are 75% similar to a (TRANSPOSASE PLASMID PROTEASE TRASNPOSASE) protein domain (PD013353) which is seen in Q9L9Q9_STRAG.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 16:34:37 2002","Tue Sep 26 17:05:37 2006","Mon Feb 14 11:29:28 2005","Thu Feb 28 16:34:09 2002","","Thu Feb 28 16:34:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1213 is paralogously related (blast p-value < 1e-3) to SMu0205, SMu0095, and SMu0084, transposase fragments.","Thu Mar 21 15:03:08 2002","","No significant hits to the NCBI PDB database.","SMU.1329c","","Residues 17 to 157 (E-value = 3.6e-06) place SMu1213 in the Transposase_11 family which is described as Transposase DDE domain (PF01609)","Thu Feb 28 16:34:09 2002","24379742","","","Spellerberg,B., Martin,S., Franken,C., Berner,R. and Lutticken,R.Identification of a novel insertion sequence element inStreptococcus agalactiae.Gene 241 (1), 51-56 (2000)PubMed: NOT_FOUND","Mon Feb 14 11:29:28 2005","Mon Feb 14 11:29:28 2005","1","","12","SMU.1329c","" "SMu1214","1253331","1253191","141","TTGGAAGCTACCAACAAGCTCATCAAAGATATCAAGCGCCAAGCTTTTGGCTTTCGAAACTTCAAAAACTTTAAAACTAAAATTCTCATCGCTTTGAACATCACAAAAGAGAGAACCAATCTGATTCTCTCTCGTGCTTAG","11.80","7.98","5374","MEATNKLIKDIKRQAFGFRNFKNFKTKILIALNITKERTNLILSRA","1253206","","transposase, IS1167, fragment","Extracellular, Cytoplasm","Matches in gapped BLAST to IS1167, transposase: residues 1-46 are 78% similar to the enzyme in S.pneumoniae (gi15900376).Residues1-45 are 71% similar to the enzyme in S.thermophilus (gi14389024) SMu1214 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 28 16:41:00 2002","Tue Sep 26 17:08:36 2006","Tue Sep 26 17:08:36 2006","Thu Feb 28 16:37:47 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1214 is paralogously related (blast p-value < 1e-3) to SMu1650, a predicted transposase.","Thu Feb 28 16:41:00 2002","","No significant hits to the NCBI PDB database.","SMU.1330c","","No significant hits to the Pfam 11.0 database","Thu Feb 28 16:37:47 2002","24379743","","","","","","1","","12","SMU.1330c","" "SMu1215","1253951","1253406","546","TTGGCCTTCATTGCACAAGATTTTGAGACGAGAAAGATTGTCACTGTCCTTGAGAACAACAAGCAATCAACCATTAAAAACTACTTCTACAACTACCCTAGAATGGTTCGAGAACGGGTTAAAGTCGTGACTGTGGACATGTCTGCTAGCTACATTCCCATCATCAAACAATTGTTTCCAAATGCTCAGATTGTTTTGGACCGGTTTCACATTATCCAACATCTGAGTCGCGCTATGATGAGTACTCGGGTAGCCATCATGAAGAGTTTTGACATCAAGTCTCTACCCTATCGAGCTATGAAAAATCATTGGCGTATTCTCCACAAGGATAGTCGGAAACTTTCTGATAAAGCCTTCTATTCACGAACTTTCAGGCAAACCTTAACACCCCGTGAGATTGTCGACAAGACGCTGGCTTTCTCTGATGAACTTCGCTATTATGACAATCTTTATCAGCTCCTGCTTTTCCATTTTCAAGAAAAGCGAGCAACTCAATTTTTTGAACTGATTGAAGACCATTTGAACCTAGTCAATCATCGTTTTTAA","10.80","12.67","21871","MAFIAQDFETRKIVTVLENNKQSTIKNYFYNYPRMVRERVKVVTVDMSASYIPIIKQLFPNAQIVLDRFHIIQHLSRAMMSTRVAIMKSFDIKSLPYRAMKNHWRILHKDSRKLSDKAFYSRTFRQTLTPREIVDKTLAFSDELRYYDNLYQLLLFHFQEKRATQFFELIEDHLNLVNHRF","1253421","","transposase","Cytoplasm","Matches in gapped BLAST to transposase: residues 1-181 are 62% similar to the enzyme in S.thermophilus (gi|2687821|) and are 61% similar to the enzyme in S.pneumoniae (gi|15900376|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2022 (1e-04).","

InterPro
IPR002560
Family

Transposase, IS204/IS1001/IS1096/IS1165
PF01610	$\"[1-86]T$	Transposase_12

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-78 are 57% similar to a (TRANSPOSASE COMPLETE PROTEOME PLASMID) protein domain (PD003298) which is seen in O86927_STRTR.Residues 80-115 are 72% similar to a (TRANSPOSASE ATCC PLASMID) protein domain (PD327821) which is seen in O86927_STRTR.Residues 118-181 are 65% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD079423) which is seen in O86927_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 4 08:32:37 2002","Mon Mar 4 08:31:40 2002","Fri Oct 18 14:29:12 2002","Mon Mar 4 08:31:40 2002","","Mon Mar 4 08:31:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1215 is paralogously related (blast p-value < 1e-3) to SMu1650, a predicted transposase, IS1167.","Mon Mar 4 08:32:37 2002","","No significant hits to the NCBI PDB database.","SMU.1331c","","Residues 1 to 177 (E-value = 8.5e-05) place SMu1215 in the Transposase_12 family which is described as Transposase (PF01610)","Mon Mar 4 08:31:40 2002","24379744","","","","","","1","","12","SMU.1331c","" "SMu1216","1254302","1254039","264","TTGTCAGGCAAATATGATTTTCAGAAAGCTTCATCCATTCCTATCCTTGACAGTCAAAGAATGCCTACTGTCCTTAAGCTCAAGAAACGACGTTTTCAGTGCAAGGCTTGTCGTAGAGTCTCTGTGTCCGAGACACCTCTCGTTCAGAAAAATTGTCAGATTTCCAAGGCTATCTGGGCTAAAATCACGCAATTACACACCGAAAAGTTGACCAACTCGGCTATCGCTAAAAGATTGCACATTTCTGTTTCTGTCGTTCAATGA","11.20","13.31","9863","MSGKYDFQKASSIPILDSQRMPTVLKLKKRRFQCKACRRVSVSETPLVQKNCQISKAIWAKITQLHTEKLTNSAIAKRLHISVSVVQ","1254054","","transposase","Periplasm, Membrane","Matches in gapped BLAST to transposase: residues 4-86 are 60% similar to the enzyme in S.thermophilus (gi|14389024|) and residues 4-84 are 54% similar to the enzyme in S.pneumoniae (gi|15900376|). SMu1216 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-86 are 60% similar to a (TRANSPOSASE ATCC INSERTION PLASMID) protein domain (PD007476) which is seen in Q9EVW8_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 14:28:45 2002","Mon Mar 4 08:36:16 2002","Fri Oct 18 14:28:45 2002","Mon Mar 4 08:36:16 2002","","Mon Mar 4 08:36:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1216 is paralogously related (blast p-value < 1e-3) to SMu1650, a predicted transposase, IS1167.","Fri Oct 18 14:28:45 2002","","No significant hits to the NCBI PDB database.","SMU.1332c","","No significant hits to the Pfam 11.0 database","Mon Mar 4 08:36:16 2002","24379745","","","","","","1","","12","SMU.1332c","" "SMu1217","1255776","1255084","693","ATGAATATTTTAATGATTAATAGTAAAAGGTTGATGAAATATGATCTGTTTTCGAGATTATTAACTTTAATTGAGGAAAGATATCAAAAAAAAATTTTACGCTATCATTTTTGGGAAGATAGGCAACGTTCTCTTTTAGGGCACCTTTTATCACGATATGCAATTATGCAACAATTTCATTTAAATAATGATAAGATTAAACTTGTCGAAAATCCTTATGGAAAACCTCATATAAAAGGATATAGGGCAATTCATTATAATATTTCTCACTCAGGTGATTGGGTTGTATGTGCCATTAGCCAATCAGTTATTGGAATAGATATTCAAAAATTTGAAGGTATGAAATTTGGAATTGTTGAACATTGTTTTTCAAAGGATGAGAGGAAGTATTTATTTTCTTTAGGAAAAGCACAACAATTAATATCTTTTTATGATATGTGGACTTTAAAAGAAGCTTATATCAAAGCTATAGGTAAGGGATTATTTCAGCAATTAAGTGAATTTTCTGTTCTTAAAGATGGAAAGGATTTTAGATTATTTACAAAAGAACCTTTGAATAAAAAATTCTTTTTCAAAAAGTATAGTATAGAGAAAGGATACAGCCTTTCTGTTTGTTCACAAGAAAATAATTTTTGTGCTAAATTAGAAGAATTATTTATTGATGATTTAATAAAAAGATTCAATTTATACTGA","10.20","13.49","27436","MNILMINSKRLMKYDLFSRLLTLIEERYQKKILRYHFWEDRQRSLLGHLLSRYAIMQQFHLNNDKIKLVENPYGKPHIKGYRAIHYNISHSGDWVVCAISQSVIGIDIQKFEGMKFGIVEHCFSKDERKYLFSLGKAQQLISFYDMWTLKEAYIKAIGKGLFQQLSEFSVLKDGKDFRLFTKEPLNKKFFFKKYSIEKGYSLSVCSQENNFCAKLEELFIDDLIKRFNLY","1255099","","phosphopantetheinyl transferase","Cytoplasm","Several matches in gapped BLAST to phosphopantetheinyl transferase : residues 1-211 are 36% similar to the enzyme in B.subtilis (gi|10954339|). Residues 1-205 are 37% similar to the protein from Clostridium acetobutylicum (gi|15894608|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1685 (7e-06).","

InterPro
IPR004568
Domain

Phosphopantethiene-protein transferase
PD004282	$\"[147-190]T$	ACPS
TIGR00556	$\"[100-227]T$	pantethn_trn

InterPro
IPR008278
Domain

4'-phosphopantetheinyl transferase
PF01648	$\"[104-166]T$	ACPS

noIPR
unintegrated

unintegrated
G3DSA:3.90.470.20	$\"[104-212]T$	G3DSA:3.90.470.20
PTHR12215	$\"[43-205]T$	PTHR12215

","BeTs to 4 clades of COG2091COG name: Yeast alpha-aminoadipate reductase small subunit and related enzymes of siderophore/surfactin biosynthesisFunctional Class: E,NThe phylogenetic pattern of COG2091 is ----y--ceb-h---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-155 are 38% similar to a (TRANSFERASE BIOSYNTHESIS SURFACTIN) protein domain (PD005299) which is seen in Q9F4F7_BACSU.Residues 43-161 are 28% similar to a (GRA-ORF32 PROTEOME COMPLETE HETI) protein domain (PD309644) which is seen in Q9ZA27_STRVN.Residues 74-169 are 34% similar to a (DOMAIN OF UNKNO N) protein domain (PD096562) which is seen in O33901_BBBBB.Residues 74-161 are 35% similar to a (PROTEOME HI0152 COMPLETE PM0116) protein domain (PD096555) which is seen in Y152_HAEIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 4 08:41:43 2002","Mon Mar 4 08:39:44 2002","Fri Oct 18 13:50:57 2002","Mon Mar 4 08:39:44 2002","","Mon Mar 4 08:39:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1217 is paralogously related (blast p-value < 1e-3) to SMu1671, a predicted acyl carrier protein synthase.","Mon Mar 4 08:42:58 2002","Fri Oct 18 14:24:16 2002","pdb|1QR0|A Chain A, Crystal Structure Of The 4'-Phosphopantethe... 128 6e-031","SMU.1334c","","Residues 104 to 166 (E-value = 3.4e-13) place SMu1217 in the ACPS family which is described as 4'-phosphopantetheinyl transferase superfamily (PF01648)","Fri Oct 18 14:24:16 2002","","","","Nakano,M.M., Corbell,N., Besson,J. and Zuber,P.Isolation and characterization of sfp: a gene that functions in the production of the lipopeptide biosurfactant, surfactin, in Bacillus subtilisMol. Gen. Genet. 232 (2), 313-321 (1992)PubMed: 1557038Grossman,T.H., Tuckman,M., Ellestad,S. and Osburne,M.S.Isolation and characterization of Bacillus subtilis genes involvedin siderophore biosynthesis: relationship between B. subtilis sfpoand Escherichia coli entD genesJ. Bacteriol. 175 (19), 6203-6211 (1993)PubMed: 8407792Reuter,K., Mofid,M.R., Marahiel,M.A. and Ficner,R.Crystal structure of the surfactin synthetase-activating enzymesfp: a prototype of the 4'-phosphopantetheinyl transferasesuperfamilyEMBO J. 18 (23), 6823-6831 (1999)PubMed: 10581256","","Fri Oct 18 14:24:16 2002","1","","12","SMU.1334c","" "SMu1218","1256787","1255804","984","ATGAGAAATAAACAAACTTTGGAAAGTATTTTAAAAATAAATTATCCAATTTTACAAGGAGCAATGGCTAATATTTCAGATTCTTCATTAGTTTCAGCTGTTAGCGAAGCTGGGGGGCTGGGAATTCTTGCGTCTGGTAATATGAAACCTGAGGAAGTCAGAGAAGAAATTCGTAAAACAAAATCAAAGACTAGTTACCCATTTGGAGTTAATATTATTATTTCTAATAAATTTTGTGACCAAATCATTGATGTTCTTCATGAAGAGAAGGTTGATATTGTTATTACAGGAAATGGGGATCCGGGTAAGTTTTTTCCAAAATTCAATGCATGGAATATGAAAGTTATTCCTGTAGTTTCTTCATATATGATGGCAAAACGTATGGAAAAGTTAGGAGCAATAGCCGTTATTGCTGAGGGAATGGAAGCGGGTGGACATATTGGTTCTATCACAACAATGTGTTTATTACCTAACATCACTAAAGATATTTCTATACCTGTAATAGCAGCAGGTGGAATTGCTAGTGGATATAGTATGATGGCTGCTTTTAACCTAGGTGCACAGGGAGTACAAATAGGAACACGTTTTTTATTAGCAAAAGAATGTAACATCCATACTAATTATAAAAAAAGAGTGATTGATTCTAATGACTTTGATTCTGTTGTTATAAAAAATATGATAAATAAACCTATTCGAAGTCTTCGAAACAAATTAACTAATTTAATTGGAAGGTTGGAATTAGAATATTTAAAAAATAGAAGTACATCTATTGAAGACATTGATTTAAAAACTATAAATGCGCTTTCAAATGCCGTTAAAAATGGAGATGTTCAAAATGGTTTAGTTATGGCAGGTCAGATATCAGCAGTGTTAACTAAAGAGGAGACTTGCAAAGAAATCATGTGCTCTATACTAAATGAATGGAATAGCTGTACAGAAAAGACCTACAGTAAATATGATTTACCACAGGTTGGCAATACTTAA","8.40","4.45","35749","MRNKQTLESILKINYPILQGAMANISDSSLVSAVSEAGGLGILASGNMKPEEVREEIRKTKSKTSYPFGVNIIISNKFCDQIIDVLHEEKVDIVITGNGDPGKFFPKFNAWNMKVIPVVSSYMMAKRMEKLGAIAVIAEGMEAGGHIGSITTMCLLPNITKDISIPVIAAGGIASGYSMMAAFNLGAQGVQIGTRFLLAKECNIHTNYKKRVIDSNDFDSVVIKNMINKPIRSLRNKLTNLIGRLELEYLKNRSTSIEDIDLKTINALSNAVKNGDVQNGLVMAGQISAVLTKEETCKEIMCSILNEWNSCTEKTYSKYDLPQVGNT","1255819","For other 'fab' genes see SMu1583 (fabZ); SMu1585 (fabF); SMu1586 (fabG); SMu1587 (fabD); SMu1588 (fabK); SMu1590 (fabH) and SMu1227 (fabD).","enoyl-acyl carrier protein(ACP) reductase; dioxygenase related to 2-nitropropane dioxygenase","Cytoplasm, Membrane","Several matches in gapped BLAST to enoyl-acyl carrier protein(ACP) reductase and to dioxygenase related to 2-nitropropane dioxygenase : residues 4-304 are 48% similar to ACP reductase in S.pyogenes (gi|15675600|). Residues 10-307 are 48% similar to the protein from Clostridium acetobutylicum (gi|15896810|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0346 (2e-80).","

InterPro
IPR004136
Domain

2-nitropropane dioxygenase, NPD
PF03060	$\"[4-307]T$	NPD

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[9-288]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51412	$\"[11-308]T$	SSF51412

","BeTs to 7 clades of COG2070COG name: Dioxygenases related to 2-nitropropane dioxygenaseFunctional Class: RThe phylogenetic pattern of COG2070 is a---yqv--bR-uj-------Number of proteins in this genome belonging to this COG is 2","***** IPB001295 (Dihydroorotate dehydrogenase) with a combined E-value of 2.1e-06. IPB001295F 82-100 IPB001295H 165-195***** IPB001093 (IMP dehydrogenase / GMP reductase) with a combined E-value of 3.7e-06. IPB001093B 8-50 IPB001093D 166-205","Residues 115-197 are 47% similar to a (DEHYDROGENASE OXIDASE OXIDOREDUCTASE BIOSYNTHESIS FMN) protein domain (PD000662) which is seen in Q9FMG0_ARATH.Residues 10-109 are 49% similar to a (PROTEOME COMPLETE DIOXYGENASE) protein domain (PD010873) which is seen in Q9FBC5_STRPN.Residues 193-301 are 37% similar to a (PROTEOME COMPLETE DIOXYGENASE) protein domain (PD032844) which is seen in Q9FBC5_STRPN.Residues 115-192 are 66% similar to a (PROTEOME COMPLETE DIOXYGENASE) protein domain (PD024891) which is seen in Q9FBC5_STRPN.Residues 193-314 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD407583) which is seen in Q9WZQ7_THEMA.Residues 193-307 are 30% similar to a (TRANS-2-ENOYL-ACP II REDUCTASE) protein domain (PD397509) which is seen in Q9EZA7_ZYMMO.Residues 165-286 are 29% similar to a (PROTEOME COMPLETE NMB1452 NMA1666) protein domain (PD358387) which is seen in Q9JTR4_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 13:49:32 2002","Mon Mar 4 09:16:05 2002","Fri Oct 18 13:49:32 2002","Mon Mar 4 09:16:05 2002","Mon Mar 4 09:16:05 2002","Mon Mar 4 09:16:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1218 is paralogously related (blast p-value < 1e-3) to SMu1588,a predicted trans-2-enoyl-ACP reductase II and SMu1957, a predicted inosine monophosphate dehydrogenase.","Mon Mar 4 09:17:40 2002","","No significant hits to the NCBI PDB database.","SMU.1335c","","Residues 4 to 307 (E-value = 7.1e-77) place SMu1218 in the NPD family which is described as 2-nitropropane dioxygenase (PF03060)","Mon Mar 4 09:16:05 2002","24379747","","","Heath RJ, Su N, Murphy CK, Rock CO. The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillussubtilis. J Biol Chem. 2000 Dec 22;275(51):40128-33. PMID: 11007778","","Mon Mar 4 09:17:40 2002","1","","12","SMU.1335c","" "SMu1219","1257738","1256800","939","ATGAAGACAGTTTATTTGTTAAATGGACAAGGATCTCAATATTATCATATGGGAAAATCTTTTTATAAAAAAAACCTTTTCTTTCGAAATACATTGAATAATTTAAATAACAAAGTAAAGGAATTATTTAATATCTCTGTTTTAGAAAATATTATGGACGATTCAAAAAAAATAAATACTCCTTTTGAAGATTTAACTTTATCAAACTTAGGTATCTTTTTTATTCAATATGGACTTTTTAAAGTCTTGGAAAAAGAAGGCATTTTACCGGATATTTTAGTAGGAGTTAGCTTCGGAGAATGCTCTTGTGCAATCATTTCTAAAAAAATTTCACTTGAAGATGGTTTAAAAACCATTGTGACTCAATCAGAATTTCTTAAAAATGCAACAAATAGTGGTTATTTAATAAATATTAATAAGGATCCTGAACAAAGTATTTTGAAAATTAGTAATGCCGAATTTGCAGGAAAATTTTCGCCAGGGAATTATCTAGTTTTTATTGAGAAGTTTGAAAAAGCTCAAGAAATAGTGGATTATGCTTCGTTCGTGAATAAGACAGCGGTAATTTTACCAGTCAAAATTCCATTTCATTCAAGGTTAATAGATGATCTAAATAAAGAGTATCTAAAAATAGTTAAGCAAAACTGTATTCAGTATTCAAGTTCTGAATATGAAATTTATTCATCAGGGAGATTGAAGACTGATAATAATTTTTCTGATCAATCATTTTGGGATATGATCCGAGAACCGATAAATTTTGAAGAAGTTATTAGTATTTTAGAGAGAAACAGTTGTCGGTATATTGAACTAGGTGCTACAAATACACTTGCAAATTCAGTCAGAGACATAATTTCAGATGTTTCAACTTCGGAAGTTTATGAATTGATGGGGGTATTTATTAATACTCAAAGAGTAATCAAAAATTTATCAAAAGAATAG","5.60","-2.69","35659","MKTVYLLNGQGSQYYHMGKSFYKKNLFFRNTLNNLNNKVKELFNISVLENIMDDSKKINTPFEDLTLSNLGIFFIQYGLFKVLEKEGILPDILVGVSFGECSCAIISKKISLEDGLKTIVTQSEFLKNATNSGYLININKDPEQSILKISNAEFAGKFSPGNYLVFIEKFEKAQEIVDYASFVNKTAVILPVKIPFHSRLIDDLNKEYLKIVKQNCIQYSSSEYEIYSSGRLKTDNNFSDQSFWDMIREPINFEEVISILERNSCRYIELGATNTLANSVRDIISDVSTSEVYELMGVFINTQRVIKNLSKE","1256815","For other 'pks' genes see SMu1226 (pksC), (pksL). From Genbank:[gi:16078773], this protein is involved in polyketide synthesis.","conserved hypothetical protein","Cytoplasm, Extracellular","Matches in gapped BLAST to pksD:residues 4-310 are 27% similar to the protein from B.subtilis (gi|16078773|).Residues 2-286 are 20% similar to the protein from Mycobacterium tuberculosis (gi|15608802|) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0347 (1e-06).","

InterPro
IPR000794
Domain

Beta-ketoacyl synthase
PTHR11712	$\"[2-292]T$	Ketoacyl_synth

InterPro
IPR001227
Domain

Acyl transferase region
G3DSA:3.40.366.10	$\"[2-304]T$	Ac_transferase_reg

noIPR
unintegrated

unintegrated
SSF52151	$\"[2-289]T$	SSF52151

","BeTs to 9 clades of COG0331COG name: (acyl-carrier-protein) S-malonyltransferaseFunctional Class: IThe phylogenetic pattern of COG0331 is ----YqvceBRhuj----inxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 5-150 are 23% similar to a (PHOSPHOPANTETHEINE TRANSFERASE SYNTHASE) protein domain (PD000287) which is seen in Q49624_MYCLE.Residues 4-148 are 31% similar to a (PROTEOME COMPLETE PKSD) protein domain (PD265212) which is seen in O34877_BACSU.Residues 190-281 are 33% similar to a (PHOSPHOPANTETHEINE TRANSFERASE SYNTHASE) protein domain (PD338968) which is seen in O34877_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 3 15:15:15 2003","Fri Jan 3 15:15:15 2003","Fri Jan 3 15:15:15 2003","Mon Mar 4 09:34:21 2002","","Mon Mar 4 09:34:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1219 is paralogously related (blast p-value < 1e-3) to SMu1587, and SMu1227, both predicted malonyl CoA-acyl carrier protein transacylases.","Fri Jan 3 15:15:15 2003","","No significant hits to the NCBI PDB database.","SMU.1336c","","Residues 4 to 300 (E-value = 3.4e-07) place SMu1219 in the Acyl_transf_1 family which is described as Acyl transferase domain (PF00698)","Fri Apr 26 17:31:55 2002","","","","","","","1","","12","SMU.1336c","" "SMu1220","1258516","1257767","750","ATGATTACTAGTAAAGATAACTTAACTTTAATTTTTGTGCATGCTTGTGGAGTTGGAAACTGGATGTGGTATAAACAAAAGGATTATTTTTCAAATTTTTCTTGTATGTTTATAGAACTTCCAGAACATGGAGATAATTATAATATTCAACCATTTAGTGTTAAAAGTGCTATTAAAATGATTGATAAAACTGTCAGAAGTGCTTCTGGAGAAGTTGTTTTAATCGGTCATGAAATGGGAGCAAGACTTATTTTAAACTATTTAGCAGAATATACAAATGATAAAGTTAAAAAAATTGTTTTGTCTAGTACTATGATAAAAACTGTTAAAGAAGGCTTATTTCATAAAATTTTACCTGCTAAAATAATTGAAAAAGAATTCGAAAAAAAGAATAAAAATTTGCAAAATATAGACTTTATAAAAAAAACTCTTGATTATTATGGAGTTGAAGAAGAATATAAAGATTATTATTTAAATGATATGAAAAGATATAAACCTAGGCAACTGATAAAAATTATTCAAGAAGGCTTGCTAAAAAAACTTCCTTTAAATTTATTTATTGACAATGATATCCCAGCTTTAATTTTAGTTGGTGAGAAGGAGACAAATGCTAACAGATTGTCCGCAAAGTTATTAAGTGAGTATTTTTCAAATAGTGAGTTAATTATAGTTGATAATTCGACAGATAATCATATTAGAACGAATTCTATGGTATTTAATGATAGAGTTAAAAATTTTATTTTAACTTGA","9.40","5.12","28937","MITSKDNLTLIFVHACGVGNWMWYKQKDYFSNFSCMFIELPEHGDNYNIQPFSVKSAIKMIDKTVRSASGEVVLIGHEMGARLILNYLAEYTNDKVKKIVLSSTMIKTVKEGLFHKILPAKIIEKEFEKKNKNLQNIDFIKKTLDYYGVEEEYKDYYLNDMKRYKPRQLIKIIQEGLLKKLPLNLFIDNDIPALILVGEKETNANRLSAKLLSEYFSNSELIIVDNSTDNHIRTNSMVFNDRVKNFILT","1257782","","alpha/beta superfamily hydrolases","Cytoplasm","Matches in gapped BLAST to alpha/beta superfamily hydrolase: residues 4-232 are 23% similar to the protein from Clostridium acetobutylicum (gi|15895737|).Residues 1-231 are 24% similar to the protein from Synechocystis sp.(gi|16805118|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2132 (3e-04).","

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[4-247]T$	G3DSA:3.40.50.1820
PTHR10992	$\"[1-247]T$	PTHR10992
SSF53474	$\"[9-247]T$	SSF53474

","BeTs to 3 clades of COG0596COG name: Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)Functional Class: RThe phylogenetic pattern of COG0596 is A---Yq-CEBR-ujgp----XNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 13:48:22 2002","Mon Mar 4 13:52:11 2002","Fri Oct 18 13:48:22 2002","Mon Mar 4 13:52:11 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1220 is paralogously related (blast p-value < 1e-3) to SMu1347, a predicted conserved hypothetical protein.","Mon Mar 4 13:52:11 2002","","No significant hits to the NCBI PDB database.","SMU.1337c","","No significant hits to the Pfam 11.0 database","Mon Mar 4 13:52:11 2002","24379749","","","","","","1","","12","SMU.1337c","" "SMu1221","1259699","1258545","1155","ATGCAAAGCACAGCTTTTTCACTTTATATTATTGATACGCTCCATGATAGCCTCATTTTTGCTACTATATTAATGAGTGCCTTACTTCCCAAAATAATTCTTGGTCCACTTGGTGGCGTTTTTGTTGATTGGTTTGATAGAAAAAAATTTCTAGTTGTCATTGATCTTATAAGTGGTGTTCTTCTACTTATATCAGCATTGGTATATGGAAATAATTTATCTTTACCAATAATTTATTTTATTTGTATTAGTTTGGGAATAATGAATTCCGTTGATGAGCCTTTGGTAGTTGCTTTAATACCATCATTGGTAGAAAAGGAAAAACTTGTTACTGCTAATTCTATTAATATGTTTAGTACAGCGCTGGGTAACATTATTGGTCCAATTTTAGGAGCAGTAGTGTACTCAAGTTTTGGAATTGATACAATTTTATATATTAATGCTTCTAGTTTTATTATTGGGGCTATCCTGGAATTTATGATTAATATAGAAAATAAAAAGAAGATTAGTCAATCTAAAACCATCTTTAATTTTCTTGAAGACTTTAAAGCAGGATTGATATATATTGTACGGAATAGAATTATTTTAGTCATTGTTGTATCTATATTTTTTCAAAATTTCTTTTTTAACGGTGCAACAACTGTAGGAGTCCCGTTTTTGGCAAAACAGATATTGAAAGTAAGTAATGCTGAGTTTGCTATTTTAGAAACTACATTGATTGTAGGTTCTATATTTGGTCTTCTGGTAGCATCAAATCTTATTAAAGATAAGCCTCTGGCTAGCCTCTTCCCCAAATTACTTTTTGTAATTTCAGTTTGCTTTTTGATGATAGGTTTAATTTGTATTTTCCTTTTAAAAAAGCAACTAATGGCTTATGTGTTCATTGCTATTATTTATATTTGTTTAGGTATGTTGTCAATGAACGTTAATGTTTTGTTTCAAACAGAAATGCAAAAAATTGTTGATGAGTCAATGTTTGGTCGAGTATCGTCATTAATATTATCTCTTATTATGTCTTCTATTCCTCTTGGACAACTGGTATATGGTTACTTATTTAAGGTTGTTAGTCCAAGTATTCCATTTTTAGTAACATTTATAGCAATTTGTTGTGTTTCAACATTATTTAGTTTATCTTTAAGAAATTCAGAATTATAA","8.20","2.95","42310","MQSTAFSLYIIDTLHDSLIFATILMSALLPKIILGPLGGVFVDWFDRKKFLVVIDLISGVLLLISALVYGNNLSLPIIYFICISLGIMNSVDEPLVVALIPSLVEKEKLVTANSINMFSTALGNIIGPILGAVVYSSFGIDTILYINASSFIIGAILEFMINIENKKKISQSKTIFNFLEDFKAGLIYIVRNRIILVIVVSIFFQNFFFNGATTVGVPFLAKQILKVSNAEFAILETTLIVGSIFGLLVASNLIKDKPLASLFPKLLFVISVCFLMIGLICIFLLKKQLMAYVFIAIIYICLGMLSMNVNVLFQTEMQKIVDESMFGRVSSLILSLIMSSIPLGQLVYGYLFKVVSPSIPFLVTFIAICCVSTLFSLSLRNSEL","1258560","SMu1221 also contains MSD2","ABC transport macrolide permease","Membrane, Cytoplasm","Matches in gapped BLAST to permease and to multidrug resistance protein: residues 1-384 are 26% similar to the enzyme in Thermotoga maritima (gi15643110). Residues 1-355 are 25% similar to the protein from Pyrococcus abyssi (gi14521293).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0240 (7e-19).","

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[1-384]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[1-353]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[1-380]T$	PTHR10074
PTHR10074:SF7	$\"[1-380]T$	PTHR10074:SF7
SSF103473	$\"[1-379]T$	SSF103473

","BeTs to 10 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 94-184 are 38% similar to a (COMPLETE PROTEOME MEMBRANE TRANSMEMBRANE) protein domain (PD004129) which is seen in Q9X158_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:40:07 2002","Thu Sep 28 09:50:16 2006","Thu Sep 28 09:50:16 2006","Mon Mar 4 13:59:00 2002","","Fri Dec 14 13:38:29 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1221 is paralogously related (blast p-value < 1e-3) to SMu0098, a predicted conserved hypothetical protein and SMu1465, a predicted multi-drug resistance efflux pump.","Mon Mar 4 13:59:00 2002","","No significant hits to the NCBI PDB database.","SMU.1338c","","No significant hits to the Pfam 11.0 database","Fri Dec 14 13:38:29 2001","24379750","","","","","","1","","12","SMU.1338c","" "SMu1222","1264157","1259790","4368","ATGATTTGGGATAAAGTGTTAGATCACAAAATTGATTCTACACAGACAAACTTCTTTTCAGAAGGAGGCAATTCATTAATAGCAACTTTAGTTATTAGTGAAATAAAAAATACTTATCATGTTGATGTATCTTTTGAAGATCTTTTAAAAAATGACTCAATAGAAAAACTTGCGAATTTTATTGTTAACCAATTATGGTTATCGAAACAAGTAATTAACAATAAAACTTTAGAAAAAGAAAGTAAATCTATAGATACTTTAGAAGAAGAAAGTGGGCCTGTGGATTCATTGAAAGCTTCTCCTCAACAAAGTAGAATGGTATTAAATCAGCTATTTAATCCTTCTTCCACAGCTTTTAATATTCCAGTTATTTTCCAATTAACTGATCAATTTGATAAAAATGAATTTGAAGATTGCTTAAAAGAAATAATAAAGAAACATCAAACTTTAAATATCAATTTTAGTATTAATGAAGACGGCATATTTCAAAAAGTGCAAAATCAAATTATTGATGTTAGAGAGATAAAAATAGCAGCATTTGATGAGACTCTTAGTAGTATTATAAGTCCTTTTGAAATTGGTAAGGATTCCTTAATCAGATTAATCTATGCCGATGCCCCTTCAGAAAAATACTTGATTCTTGATTTTCATCACAGTATTATAGATGGTTATTCAATTGTTTTGTTACACAATGAACTTTTTAAAAAACTTTCTGATGAAAAGATCTATTTTGAAAATGTGGACTATTTTGATTATTGTATTTGGATGGAAAAATATATTCACTCACCGAGCTATAAAAAACAAGAAAAATTTTGGTTGAAAATTTTTGAGAATTATCAATTAATTCAACATTTAAAGCAAAAATCAAATTCTACTTTTGAGGGAGATTCCATTGAATTCTCGTTCTCAAAGGATTTAAATAAAAAGATTCGTGAAACAACTAAAGAATGGGGGATAAGTATATATTCATTTTTGTTATCTATGTACGCTCAACTTATACATAAAGAACATAATTTATACGATTTTATCATTGGAACTCCAGTTTCTGGTAGAACAAACCCGAGGTTTATAAAAACTATTGGGATGTTTATAAATACTTTACCAATTAGAGTAAAGATTAATGATTCAGAAAATTACGAGCAATATAGCCAACGAATGAATTCTAATATAAGAAAAATGTTAGAAAATCAAGACTATCAATTTGATCATTTGGTAGAGCAATTAAAAAAAATCAATCCTCAACTACCTCGTTTGGAATTTGAAACAATGTTCAATTATCAAAATTATAGTCGTAATTGGAAATCTCTAGAGAAATTTGGCTTAAATCATATTACAGTCCGACAAAATTCAGAAAAATTCAATTTTTCAATGACACTTGAAGAACGGGAAGACGAGATATTAGGATGCTTTAGTTTTAATGTTGAAGTTTTAACAAGGAATGAAGCAAAATGGTATGTTGAGCAGTTTATAAATATTTGTGAAGAGGCTGTAGTTCAGAAAGATATTAATACTGTCACAACATTACAAAATATTGAAGATACTAATATTTATTATAAAATAATGGAAAACCTTAGTGACTTTAATGGAAAAACTGCTTTAGTCTCTTATAAAAGTAAGGTAGAGTATGCAGAACTAGATCAATTTGTGGATAATTATGTTCAAAGATTCAAACAAGAAGGAATAAGAAAATCTGATAGAATTGCTATTATGATGGATCGTTCCATTGAAAATGTTTTAGTTATATTAGCGATATTAAAAATTGGTGCGTGTTATATACCTATAGATTCAAAATTCCCTGAGTCAAGGAAAAAATTTATACTGAAGGATGCTAACTGTAAATATATTGTTAACAATAAACAGGTGATTAAAAATGTTGAGTATGAAGCAAAAGAATTAGATAGTTCTGAGTTAAATTTAGCTTATATTATTTATACTTCTGGTTCTACAGGACAACCTAAGGGAGTAAAGATAACGCAAAGTAATCTTTATAGCTTTTTAAAAGCTATTTCTAACAGATTCAGTCAGTATAATTATTCTTCTATTTTGTGTGTGACATCAATTTCCTTTGATATATTTATTCTTGAAACCCTTTTCCCAATATTTATGGGGAAAACATGTGTTTTTGCAAGCGATGAAGAAATTGAAGATATATCAAAGTTGACTCAGTTAATAAGAATATACCAAGTTGATACAATTCAAAGTACACCATCCAGATGGGGAATTTTTACAGAAGATGAGCAGCTTATGACACTTTTGAAAGAGCGACTAAAACTTGTTTTAGTTGGGGGTGAAAAGCTGACAAAAAATATTGCTGAGAAATTACTTTCGATTGGTGGAAAGCTTATTAATTTATATGGACCAACGGAAGCAACGGTTTGGGCCTTTGCTAGTGAGGTAACGGATCCTAATCAAATTTATCTAGGTGAGCCTTTAAATAATACAACAGCTTATATTTTAGACGAGAATGGAAAAGAAAGTCCAAAAGGTGAGTTGTGTTTACAAGGTTCAGGAGTTTCACCTGGCTACCAAAATAGACCAGAACTGACAGAAAAAAGTTTTGTAAAATCTTTAAAACATGGCAACAATATCTTATATCATACGGGAGATATTGTAGAATATACTAATGATCAAGATTATCTGTTTATTGGAAGAAAAGATGATCAAGTTAAGGTAAATGGATATAGGGTTGAACTAGGGGAAATAGATTCAATAATATCAAAAATGTCAAAAATAAAAAGAGCAAAAACTATTTATCAGGAAGAAACAGGGAATCTAATAGCTTTTTGTGAGTCAAAAGAGCATTGTAGTGATATTGAAACTAGAAAAGAATTATCTAAAATTTTGCCCAAATATATGCTTCCTAATTCCATTATCTTTCTTTCTGAAATGCCGTTGATGATCAATGGAAAAATAGATACTTCCAAATTAAAAAATAAATATCTTCAAATCGCTAAAAAATCACTTGTTCTGTCTGAAAATGTCGAAGAATTATCGGCGACACAACAGCACTTAATTAAAATATTTAAATCAGTTACTGGCTATGCTTTGGATCGTGACGAAAATTTTTTTGAAGTCGGAATATCTTCATTGAATATTTTAAGAGTGATTCAGCATTTGAAAAAGACTTATTCTGTTGATTATTCTAATCTTGTAGATTATCCTACTATCAGTAGCTTGTCTTCCTATTTAGATAATTTGAGTGAAAAAAAATTGGTTCGAAAAGTTAATTCGGATAAAGATAGAACGCAAATTTCGAAAATAAATGAGCGAGAGGTATTAAATGTTGGAAGAAAAGGCATACTGCTAACAGGTTCGACAGGATTTTTAGGTTGTCATCTTTTGAAGGAACTTCTCAAACAGAAAAGACCGATTCATTTATTGATTAGAGGAAAAAATGTAGAAGATATTTATAAAAGATTAGCAGAGAAATTCTATTATTACTTCTCAGAGGATTTAGCAATTTATAGTTCTCAACTCCATTTTTACTGTGGGGATTTGGAAAAAGTTTACTGTGGACTTGAAGAATCTGAGTTTAAAAAGCTATGTACCCAAGTTAGTGATGTTATCAATAGTGCAGCAAGTGTTAAACACTTTGGGAAATATGAAGATTTTTATAAAAGTAATGTCATTTCTGTTAAAAATCTCATTACATTTTGTAAAGAATCACAATCAGCTCTATTTCATATATCAACTATATCTTTAGCAAATATCTGTGATTTAAAGGCAAATCAAAGTTTTTCTGAAGAAATTATTTTGACTAATGCTTCAACATCAAATGTTTATTTGCAAACAAAATATGAAGCAGAAAAAACCATTTTTGAAGCAATTTCAGAAGGGTTAAAAGCTAACATATTAAGAGTTGGTAATATTGTTGGAAGCAGTAAAACTGGAATTTTTCAAATGAATATAGAAGAGAATGCCTTTTATCAGATTTTAAGATCATTTTTTAAATTAAAAATGATACCTGATAGTAATGAAAAATCACTTGAATTCACTTTCGTAGACGAATGTGCTTTAGCAATAAGTGAAATAATTAATAATAAACATTTAACAGGTGTTTATCATATATTTAATCAGAATAAAATTTCATTTAATGAATTGTTTGATTTTATAAAAACTCAATATCCATATTTAAAAAAGATGACTTTTTCAAAAATTGAAGAGACACAAGGACTAAAGGGGACAGATGCTGAAGAGTATTTTGATATTATAAAAATTCATTCAAGTACTGCTAATAAAAATGTCGCAAAGATTGATAATATTTTTACAAATCAGTTGCTTGATAAATACAATTTTTGTTGGAGCCGTGTTGATAAAAAGACCATATTGCTATTACTAGAATATTGTAAGGAAATTAATTTTATTTAA","6.20","-12.73","168262","MIWDKVLDHKIDSTQTNFFSEGGNSLIATLVISEIKNTYHVDVSFEDLLKNDSIEKLANFIVNQLWLSKQVINNKTLEKESKSIDTLEEESGPVDSLKASPQQSRMVLNQLFNPSSTAFNIPVIFQLTDQFDKNEFEDCLKEIIKKHQTLNINFSINEDGIFQKVQNQIIDVREIKIAAFDETLSSIISPFEIGKDSLIRLIYADAPSEKYLILDFHHSIIDGYSIVLLHNELFKKLSDEKIYFENVDYFDYCIWMEKYIHSPSYKKQEKFWLKIFENYQLIQHLKQKSNSTFEGDSIEFSFSKDLNKKIRETTKEWGISIYSFLLSMYAQLIHKEHNLYDFIIGTPVSGRTNPRFIKTIGMFINTLPIRVKINDSENYEQYSQRMNSNIRKMLENQDYQFDHLVEQLKKINPQLPRLEFETMFNYQNYSRNWKSLEKFGLNHITVRQNSEKFNFSMTLEEREDEILGCFSFNVEVLTRNEAKWYVEQFINICEEAVVQKDINTVTTLQNIEDTNIYYKIMENLSDFNGKTALVSYKSKVEYAELDQFVDNYVQRFKQEGIRKSDRIAIMMDRSIENVLVILAILKIGACYIPIDSKFPESRKKFILKDANCKYIVNNKQVIKNVEYEAKELDSSELNLAYIIYTSGSTGQPKGVKITQSNLYSFLKAISNRFSQYNYSSILCVTSISFDIFILETLFPIFMGKTCVFASDEEIEDISKLTQLIRIYQVDTIQSTPSRWGIFTEDEQLMTLLKERLKLVLVGGEKLTKNIAEKLLSIGGKLINLYGPTEATVWAFASEVTDPNQIYLGEPLNNTTAYILDENGKESPKGELCLQGSGVSPGYQNRPELTEKSFVKSLKHGNNILYHTGDIVEYTNDQDYLFIGRKDDQVKVNGYRVELGEIDSIISKMSKIKRAKTIYQEETGNLIAFCESKEHCSDIETRKELSKILPKYMLPNSIIFLSEMPLMINGKIDTSKLKNKYLQIAKKSLVLSENVEELSATQQHLIKIFKSVTGYALDRDENFFEVGISSLNILRVIQHLKKTYSVDYSNLVDYPTISSLSSYLDNLSEKKLVRKVNSDKDRTQISKINEREVLNVGRKGILLTGSTGFLGCHLLKELLKQKRPIHLLIRGKNVEDIYKRLAEKFYYYFSEDLAIYSSQLHFYCGDLEKVYCGLEESEFKKLCTQVSDVINSAASVKHFGKYEDFYKSNVISVKNLITFCKESQSALFHISTISLANICDLKANQSFSEEIILTNASTSNVYLQTKYEAEKTIFEAISEGLKANILRVGNIVGSSKTGIFQMNIEENAFYQILRSFFKLKMIPDSNEKSLEFTFVDECALAISEIINNKHLTGVYHIFNQNKISFNELFDFIKTQYPYLKKMTFSKIEETQGLKGTDAEEYFDIIKIHSSTANKNVAKIDNIFTNQLLDKYNFCWSRVDKKTILLLLEYCKEINFI","1259805","For other 'bac' genes see SMu0221 (bacA); SMu1225 (bacA) and SMu1229 (bacT).","bacitracin synthetase; surfactin synthetase","Cytoplasm, Extracellular","Residues 17-1452 are 26% similar to residues 933-2388 of gi|21281882 hypothetical protein, similar to surfactinsynthetase [Staphylococcus aureus subsp. aureus MW2]. Residues 2-1108 are 27% similar to residues 973-2112 of gi|5915762 BACC_BACLI Bacitracin synthetase 3 (BA3) [Includes: ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); ATP-dependentD-phenylalanine adenylase (D-PheA) (D-phenylalanineactivase); ATP-dependent histidine adenylase (HisA)(Histidine activase); ATP-de>Significant hits in gapped BLAST to bacitracin synthetase: residues 2-1108 are 27% similar, residues 2-1069 are 26% similar and residues 50-1068 are 25% similar to gi|5915762| from B.licheniformisThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1790 (2e-40).","

InterPro
IPR000873
Domain

AMP-dependent synthetase and ligase
PR00154	$\"[637-648]T$ $\"[649-657]T$	AMPBINDING
PF00501	$\"[541-916]T$	AMP-binding
PS00455	$\"[642-653]T$	AMP_BINDING

InterPro
IPR001242
Domain

Condensation domain
PF00668	$\"[93-374]T$	Condensation

InterPro
IPR006162
PTM

Phosphopantetheine attachment site
PS00012	$\"[1024-1039]?$	PHOSPHOPANTETHEINE

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[1-61]T$ $\"[1002-1063]T$	PP-binding
PS50075	$\"[1-62]T$ $\"[993-1064]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[2-61]T$ $\"[986-1073]T$	ACP_like
SSF47336	$\"[2-63]T$ $\"[993-1065]T$	ACP_like

InterPro
IPR013120
Domain

Male sterility C-terminal
PF07993	$\"[1102-1341]T$	NAD_binding_4

noIPR
unintegrated

unintegrated
G3DSA:2.30.38.10	$\"[805-882]T$	G3DSA:2.30.38.10
G3DSA:3.30.300.30	$\"[891-976]T$	G3DSA:3.30.300.30
G3DSA:3.40.50.720	$\"[1098-1385]T$	G3DSA:3.40.50.720
G3DSA:3.40.50.980	$\"[511-660]T$ $\"[661-801]T$	G3DSA:3.40.50.980
PTHR11968	$\"[542-1026]T$	PTHR11968
PTHR11968:SF36	$\"[542-1026]T$	PTHR11968:SF36
SSF51735	$\"[1098-1408]T$	SSF51735
SSF56801	$\"[515-1009]T$	SSF56801

","BeTs to 4 clades of COG1020COG name: Acyl-CoA synthetases (AMP-forming)/AMP-(fatty) acid ligases IFunctional Class: IThe phylogenetic pattern of COG1020 is ----y---eBR----------Number of proteins in this genome belonging to this COG is 4","***** IPB000873 (AMP-dependent synthetase and ligase) with a combined E-value of 7.7e-07. IPB000873A 644-659","Residues 770-820 are 47% similar to a (PHOSPHOPANTETHEINE SYNTHETASE PEPTIDE CDA) protein domain (PD204223) which is seen in Q9Z4X5_STRCO.Residues 292-408 are 37% similar to a (SYNTHETASE PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD000924) which is seen in BACB_BACLI.Residues 864-1076 are 23% similar to a (PHOSPHOPANTETHEINE G01D9.5 C41A3.1 09D6.1) protein domain (PD360048) which is seen in Q18559_CAEEL.Residues 1100-1227 are 32% similar to a (PHOSPHOPANTETHEINE STERILITY MALE) protein domain (PD350279) which is seen in O74298_PENCH.Residues 641-742 are 28% similar to a (MCYB PHOSPHOPANTETHEINE) protein domain (PD396892) which is seen in Q9S1A8_MICAE.Residues 780-845 are 50% similar to a (SYNTHETASE PHOSPHOPANTETHEINE LIGASE) protein domain (PD000107) which is seen in BACA_BACLI.Residues 881-951 are 39% similar to a (LIGASE SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD000081) which is seen in Q45295_BACLI.Residues 409-720 are 20% similar to a (PHOSPHOPANTETHEINE G01D9.5 C41A3.1) protein domain (PD034003) which is seen in Q17301_CAEBR.Residues 1103-1298 are 27% similar to a (COMPLETE PROTEOME 4-EPIMERASE REDUCTASE UDP-GLUCOSE NAD) protein domain (PD000038) which is seen in Q9P3Q7_NEUCR.Residues 641-742 are 28% similar to a (PHOSPHOPANTETHEINE REDUCTASE) protein domain (PD034004) which is seen in Q9RNB0_MICAE.Residues 587-773 are 26% similar to a (PHOSPHOPANTETHEINE PEPTIDE SIDEROPHORE) protein domain (PD204212) which is seen in SID2_USTMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 17:29:24 2002","Tue Oct 22 11:33:58 2002","Tue Oct 22 16:46:56 2002","Mon Mar 4 14:16:35 2002","Mon Mar 4 14:16:35 2002","Mon Mar 4 14:16:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1222 is paralogously related (blast p-value < 1e-3) to SMu1225, to SMu1223, a predicted D-Ala-D-Ala carrier; and to SMu1224, SMu1541, SMu1226, SMu1228.","Tue Oct 22 16:59:07 2002","Mon Mar 4 14:16:35 2002","pdb|1AMU|B Chain B, Phenylalanine Activating Domain Of Gramicid... 221 5e-058pdb|1BA3| Firefly Luciferase In Complex With Bromoform >gi|20... 83 3e-016","SMU.1339c","","Residues 1 to 61 (E-value = 4.5e-05) place SMu1222 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)Residues 93 to 374 (E-value = 4.7e-36) place SMu1222 in the Condensation family which is described as Condensation domain (PF00668)Residues 541 to 916 (E-value = 7e-105) place SMu1222 in the AMP-binding family which is described as AMP-binding enzyme (PF00501)Residues 1002 to 1063 (E-value = 9.8e-06) place SMu1222 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)","Mon Mar 4 14:16:35 2002","","","","Cosmina,P., Rodriguez,F., de Ferra,F., Grandi,G., Perego,M., Venema,G. and van Sinderen,D.,Sequence and analysis of the genetic locus responsible for surfactin synthesis in Bacillus subtilis,Mol. Microbiol. 8 (5), 821-831 (1993)PMID: 93360813.,","Tue Oct 22 16:32:31 2002","Tue Oct 22 16:32:31 2002","1","","12","SMU.1339c","" "SMu1223","1269141","1264255","4887","ATGGAGCAGCAAAAGAAATTTAAAAATAATCAATTTGATTATGATAATTATCTCACTATAATTAACGAGTTCGAAAAACAGGTAGAACGATTTCCAGATAAGATTGCAATTATTCATAATGATACAAGAATAACTTATAAGGAGCTTAATATACTAGCAAATAAAGTTGGAAATATTTTAATTTCTTCTGGGGTTGATAATGGTGATAAAGTCGCAATTGACATGAAACGAGGAATTTCTTATATTGCTGCAATTTTGGGAATTTTAAAAATAGGAGCTATCTATGTCCCACTAGATTTTGATTTTCCTCAATCAAGAAAAGAATATATCCTGAACGATTGCCGGTCGAAAATTATTATCACAGAATCAGATATTGAATATAAAAATTATAAAAAAGTAAATTGGAACCAAATTATAGAAGGATCTTCCTCAAAGGATTTAGTAACAGATCATTATGTCAAAGAAAGTTTAGATGAAATTGTTTATATTATGTATACTTCTGGGACTACGGGTTTTCCTAAGGGAGTGCAGGTTGGCGGAAGAGGAATTATTCGTTTGATAAAGGACAATAAAAGCTTAACAATGAAAAATACAGAAGTTATGCTACATGGTTCTTCTTTAGCATTTGATGCGTCAACATTAGAAATATATGCAGCTCTTTTAAATGGTGCATGCCTATCTATCATTGATAAGGAGGATTTAATTGATAGTCAAACATTAAAAGAAAAGTTGAAAAATGATCATGTCAATCGAGCCTTTTTTACAACCCCTTTATTTAATTCATTGTGTGAGCAAGATCCAAGTGTATTCAATGAGCTTGAACAAGTAATTATAGGTGGAGATAGAGCATCTAATAAACACCTAAAAATAGTAATGAAGAATAGCAAGAAAACTCAATTTTATAATGGATACGGACCAACAGAAAACACTGTTTTTACGACCATGCATAATATTCAATACTCAGAGTTAGAAGGTGATATTCCGATCGGTAAAGCAATTAATGATACTGGAATTCTTATCGTTAATGAAAATTTTGAAGAAGTAAAAAAAGGGGAAGTTGGAGAATTAGTTGTAACAGGTGGAGGTCTTGCTATTGGTTATCTAAATCAAAAAGATGCTTCTCAAGGTTCCTTTATTTCTCTTCCAAATCTAGGGATCAAACGTGCTTATAAAACAGGAGATTATGTTAGAGAAAATAATGATGGGGATCTCATTTTTATTGGCCGCAGAGATAGTCAAATTAAGTATCGAGGTTTTCGAATAGAACTTAGAGAAATTGAAAGTATTGCAAAAAAGATTGATCATATTAGAGAAGCTATTTGTCTCCTAATTGGTGAAAAATCTAATTCTAAATTAGTTCTTTTTGCTGAGTCTAATTCTTCTGTGTCAGAAGCTTCTATTATTGAAACACTTCATGTTGAGCTTCCAGAATATATGGTGCCCAATGATCTTATTTTGCTAGATAATATGCCATTAAAACTTAATGGGAAAGTTGATTCTGACAAGCTTAAACAAATCTATTTGGAAAAAATACAAAGTCAGGTTGAAAAACCTAGCGAAAGTAACACAGAGAGATTTTTCATAGAAATTTTGGAAGATGTGTTAAAAAAGCCAAACCTTAATTTAGAGATGAATTTTTTTGAAATTGGTGGACATTCTTTAAATGCAACAATTATATCAACAAGACTATCAGAAGCATTTCATAAAAAAATTTCTGTCAGAGATGTTATGTTAAATCCAAATTTGAAAGATTTGTTTCATTTGACTAAGGTGACAGAAGATGACGCTGGCTCTAATTTAGAAGTGCTATCAAAAGCTGATAATTATGATTGTTCTCCTACTCAGTCTAGACTTTTTCTGTTAAACAAGAGCCGAAGTGACACATCTTATAATATTCCATATTTCATTAAGGTAAGTAGCAATATTGATATGGAACAACTAAAAAAGGCTATTTGGAAAGAACTAAAAGAAAATGAAATTTTAAGAACAATTTATACATTTAACAATTCCAAAATTGTCCAAAAAGTTCTTCCGTTTGAGAAAAAACTACTTAATATTTCTGTAGAATATGAACCAATAATTGATTTTGAGTATTTGCAAAAGTATTTGATTCAACCATTTGATTTGGAAAAATCAATTCCCTTTAGGGCTTCTATCATAAAATCCAATAGTGATATCATCCTTTTTCTAGACATTCATCATATTGCCATAGATGGTTTTTCATTAAATCAATTATTAAAAAATATTGAAAAAAACTATTTTGAAATTAAATTTACGCGTCCTAAATTTACTTATAAAGATTACTCTAATTGGATAAATAAACAGATTAGTAATGGTAAGTATATGCAAAAGAAGCAGTATTGGCAAGAACAGCTTAAAGGTTATCAGGAGAATATATTTTTAGGAATTGAAAAAACTATAAAACCCAATTCTAAACGAACGATTTACTATAATAGAGAAATATCTTCACAATTATATGAACAATTGAGAGATTATATAGTTACAAATAATATTAGTCTAAATATACTTTTTATGACTGCACTTTACATTCTTATAGCTAAATATTCCTCAATTAATGATATAGTTATTGGTTCCCCTGTTTCAGGAAAAGTATTAGCGGATTTGGAAGAAATGATTGGTTCTTTTATTAATAGCTTACCAATTAGATATAAAGTAGATCCATCAAAAACTATCTTGGAAACGATTGAGGATGTAAAAAAGCAAGTGATGGATGCATTAGAAAATCAAGAATATCCGATTGATTCGATAGTTAGTGATAAGAATAAAGAAAATACGGAAATTGCTTCTTTGTTTGATATTATGTTTGTTATGCAGACCAATTTCAAGCAAGGTGAACAAGAAAAATCAAATCAGATATTTTTAGACTATCAAGAGATTCCGATTGATTCTAAAATGAATTTAATTGTTGAAGGAATTGATTTTGGAAATACGGTAAAGTTTCAAATAACTTACCCTGTTGAACTGTATGATGATGACAGTATTATTCAGCTTATGGATTCATTTTTACAAGTTATTGAGTCAATTATTCAAAATGATAGAAGGTGTGTAAAGGAAATAGAAATTATTTCTCAAGATCAAAAAGATTTTATTGATTTAAATTATAATAAAACAGCTAAGGATTTTAAATTTGATAATCAGTGTTTGAAACAATTGATCGAAAGAAATGTAGCGAAGATGCCTAATAAAATTGCTATTGCCTGTGATGAAGAAAATATTAGTTTTGAACAATTAAATATGAGATCTAATTTTATGGCCAATAAATTAAAAGATTTAGGCTTACAAGTGGGCGATGTAGTTGGTGTCATGAAAGATAGAAATATTGAGGCAATAATCATTATACTAGCTTTAATTAAACTAGGAGTAACATATGTTCCCTTGGATTCGGGAACGCCAATTGAAAGAGTTAAAAAGATTTTTGTTAAATCTGGAATGAAATTTGTAATAACTGATTTGGTACCTTTGCAGAAAGATATACTAATTATTGATACTAATGCTCCAGACTTTCAAGGTTTGTCTAAACAAAATCCAAAAACAGAGATCAATTTAGATCAGATGCTATATATCATATTTACTTCGGGAAGTACTGGTGAGCCCAAAGGAGTAGCTATTTCAAATAAACAGTGTATTAATACTATTTTGGATATTAATCATAAGTTTACACTATCTCCAAAAGATAATATTCTATTGATTTCATCTTTTGCATTTGATCTTTCAGTGTATGACATATTTGGTGCATTAGTTTCTGGGGCAACTTTAACTATTGCTAGTCAAAATAAAGACACAAATTATTTGAAAAAAGTCGTTCAAAATAACCCGATTACAGTTTGGAATTCCGTACCAGCGTATATGGAATTAATTTGTAATGTATTAGCAGACCAGAAGCCAATATTAAGTATTAGAAATATTATTCTGAGTGGTGATTGGATACCATTAGAATTGCCTTTGAAAATAAAAAAAATCTTTCCTAATGCTAATCTTTTTAGTGCAGGAGGTGCTACTGAAGGATCAATATGGTCAATTTATTACCCAATTGTTAAAGTTGAACCAGAATGGAAATCAATACCTTATGGAATGCCTTTGGCTAATCAACAGATGTATATTCTGAATAATATGGGAAATGAACTTCCTATTGGAGTTATGGGAAATATATATATTGGAGGAGTAGGAGTTGCAATGGGCTACATTAATGATATTGAGAAAACTAATGATAGTTTCATTAATCATCCTAAATTAGGCAGAATTTATAAGACAGGTGATTTGGGACGCTTAACTTCCCAAGGATACATGGAATTTTGTGGAAGAAAAGATATTCAAGTAAAAGTTAACGGAAATAGAATAGAGTTAGGAGAAATTCAAGCAATTCTTCAATCTTTTGAGACCATTCAAAATGCGATAGTAACTGTAGGACAGAATGATTATCAAAAACAATTGCTGGCATATTATAAATCTGATAATGAAATTGAAAAAGATGTACTGAATCAGTTTATGAAACAATATTTACCAAATTATATGATTCCTAGCCATTATATTTATATGTCAGAGTTCCCATTAACTTCAAATGGTAAAATTGATAAAAAACAATTACCGGATCCTAAAAAAATAGAATCTATTAAAGAGGTAAAAGATGTAAAACCTAAAAATCAGTTAGAAGAGACCGTTTTGACAATTTGGGAGAATGTATTGGAACATCAAGTTCTTTCTGTAACAGACAGTTTCTTCTCAGAAGGAGGCAATTCATTAATGGCCACGGTCATTATAGGTCAGATAAAGGATCAATGTAATGTTGATTTATCTCTAGAGGAATTCTATGAAAATGACTCAATAGAGGCTTTAGGAAATTTAATAATAGATAAGTTACTTTTTTAA","5.20","-28.26","185510","MEQQKKFKNNQFDYDNYLTIINEFEKQVERFPDKIAIIHNDTRITYKELNILANKVGNILISSGVDNGDKVAIDMKRGISYIAAILGILKIGAIYVPLDFDFPQSRKEYILNDCRSKIIITESDIEYKNYKKVNWNQIIEGSSSKDLVTDHYVKESLDEIVYIMYTSGTTGFPKGVQVGGRGIIRLIKDNKSLTMKNTEVMLHGSSLAFDASTLEIYAALLNGACLSIIDKEDLIDSQTLKEKLKNDHVNRAFFTTPLFNSLCEQDPSVFNELEQVIIGGDRASNKHLKIVMKNSKKTQFYNGYGPTENTVFTTMHNIQYSELEGDIPIGKAINDTGILIVNENFEEVKKGEVGELVVTGGGLAIGYLNQKDASQGSFISLPNLGIKRAYKTGDYVRENNDGDLIFIGRRDSQIKYRGFRIELREIESIAKKIDHIREAICLLIGEKSNSKLVLFAESNSSVSEASIIETLHVELPEYMVPNDLILLDNMPLKLNGKVDSDKLKQIYLEKIQSQVEKPSESNTERFFIEILEDVLKKPNLNLEMNFFEIGGHSLNATIISTRLSEAFHKKISVRDVMLNPNLKDLFHLTKVTEDDAGSNLEVLSKADNYDCSPTQSRLFLLNKSRSDTSYNIPYFIKVSSNIDMEQLKKAIWKELKENEILRTIYTFNNSKIVQKVLPFEKKLLNISVEYEPIIDFEYLQKYLIQPFDLEKSIPFRASIIKSNSDIILFLDIHHIAIDGFSLNQLLKNIEKNYFEIKFTRPKFTYKDYSNWINKQISNGKYMQKKQYWQEQLKGYQENIFLGIEKTIKPNSKRTIYYNREISSQLYEQLRDYIVTNNISLNILFMTALYILIAKYSSINDIVIGSPVSGKVLADLEEMIGSFINSLPIRYKVDPSKTILETIEDVKKQVMDALENQEYPIDSIVSDKNKENTEIASLFDIMFVMQTNFKQGEQEKSNQIFLDYQEIPIDSKMNLIVEGIDFGNTVKFQITYPVELYDDDSIIQLMDSFLQVIESIIQNDRRCVKEIEIISQDQKDFIDLNYNKTAKDFKFDNQCLKQLIERNVAKMPNKIAIACDEENISFEQLNMRSNFMANKLKDLGLQVGDVVGVMKDRNIEAIIIILALIKLGVTYVPLDSGTPIERVKKIFVKSGMKFVITDLVPLQKDILIIDTNAPDFQGLSKQNPKTEINLDQMLYIIFTSGSTGEPKGVAISNKQCINTILDINHKFTLSPKDNILLISSFAFDLSVYDIFGALVSGATLTIASQNKDTNYLKKVVQNNPITVWNSVPAYMELICNVLADQKPILSIRNIILSGDWIPLELPLKIKKIFPNANLFSAGGATEGSIWSIYYPIVKVEPEWKSIPYGMPLANQQMYILNNMGNELPIGVMGNIYIGGVGVAMGYINDIEKTNDSFINHPKLGRIYKTGDLGRLTSQGYMEFCGRKDIQVKVNGNRIELGEIQAILQSFETIQNAIVTVGQNDYQKQLLAYYKSDNEIEKDVLNQFMKQYLPNYMIPSHYIYMSEFPLTSNGKIDKKQLPDPKKIESIKEVKDVKPKNQLEETVLTIWENVLEHQVLSVTDSFFSEGGNSLMATVIIGQIKDQCNVDLSLEEFYENDSIEALGNLIIDKLLF","1264270","","bacitracin synthetase 1/ tyrocidin synthetase III","Cytoplasm, Extracellular","Residues 7-1618 are 30% similar to residues 26-1647 of gi5915760 BACA_BACLI Bacitracin synthetase 1 (BA1) [Includes: ATP-dependent isoleucine adenylase (IleA) (Isoleucine activase); ATP-dependentcysteine adenylase (CysA) (Cysteine activase);ATP-dependent leucine adenylase (LeuA) (Leucineactivase); ATP-dependent glutamate ad>. Other stretches display significant similarities with both proteins being greater than 1600 amino acids.Residues 7-1622 are 28% similar to residues 3564-5190 of gi6136084 TYCC_BACBR Tyrocidine synthetase III [Includes: ATP-dependent asparagine adenylase (AsnA) (Asparagine activase); ATP-dependent glutamine adenylase (GlnA) (Glutamine activase);ATP-dependent tyrosine adenylase (TyrA) (Tyrosineactivase); ATP-dependent valine adeny> and again other stretches sho significant similarities. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1790 (3e-46).","

InterPro
IPR000873
Domain

AMP-dependent synthetase and ligase
PR00154	$\"[158-169]T$ $\"[170-178]T$	AMPBINDING
PF00501	$\"[45-441]T$ $\"[1080-1473]T$	AMP-binding
PS00455	$\"[163-174]T$ $\"[1195-1206]T$	AMP_BINDING

InterPro
IPR001242
Domain

Condensation domain
PF00668	$\"[605-893]T$	Condensation

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[525-589]T$ $\"[1558-1622]T$	PP-binding
PS50075	$\"[519-590]T$ $\"[1556-1623]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
SSF47336	$\"[516-587]T$ $\"[1549-1624]T$	ACP_like

InterPro
IPR010071
Domain

Amino acid adenylation
TIGR01733	$\"[45-441]T$ $\"[1080-1473]T$	AA-adenyl-dom

noIPR
unintegrated

unintegrated
G3DSA:2.30.38.10	$\"[327-407]T$ $\"[1361-1439]T$	G3DSA:2.30.38.10
G3DSA:3.30.300.30	$\"[411-517]T$ $\"[1448-1542]T$	G3DSA:3.30.300.30
G3DSA:3.40.50.980	$\"[15-181]T$ $\"[185-326]T$ $\"[1050-1213]T$ $\"[1214-1351]T$	G3DSA:3.40.50.980
PTHR11968	$\"[9-155]T$ $\"[1154-1583]T$	PTHR11968
PTHR11968:SF36	$\"[9-155]T$ $\"[1154-1583]T$	PTHR11968:SF36
SSF56801	$\"[19-532]T$ $\"[1015-1565]T$	SSF56801

InterPro
IPR000873
Domain

AMP-dependent synthetase and ligase
PR00154	$\"[371-382]T$ $\"[383-391]T$	AMPBINDING
PF00501	$\"[256-654]T$	AMP-binding
PS00455	$\"[376-387]T$	AMP_BINDING

InterPro
IPR001242
Domain

Condensation domain
PF00668	$\"[820-1104]T$	Condensation

InterPro
IPR006162
PTM

Phosphopantetheine attachment site
PS00012	$\"[761-776]T$	PHOSPHOPANTETHEINE

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[738-802]T$	PP-binding
PS50075	$\"[736-803]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[734-812]T$	ACP_like
SSF47336	$\"[734-838]T$	ACP_like

InterPro
IPR010071
Domain

Amino acid adenylation
TIGR01733	$\"[256-654]T$	AA-adenyl-dom

noIPR
unintegrated

unintegrated
G3DSA:2.30.38.10	$\"[539-620]T$	G3DSA:2.30.38.10
G3DSA:3.30.300.30	$\"[629-714]T$	G3DSA:3.30.300.30
G3DSA:3.40.50.980	$\"[226-394]T$ $\"[395-531]T$	G3DSA:3.40.50.980
PTHR11968	$\"[220-763]T$	PTHR11968
PTHR11968:SF36	$\"[220-763]T$	PTHR11968:SF36
SSF52777	$\"[29-213]T$	SSF52777
SSF56801	$\"[230-742]T$	SSF56801

","BeTs to 4 clades of COG1020COG name: Acyl-CoA synthetases (AMP-forming)/AMP-(fatty) acid ligases IFunctional Class: IThe phylogenetic pattern of COG1020 is ----y---eBR----------Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 1022-1133 are 33% similar to a (SYNTHETASE PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD000924) which is seen in BACA_BACLI.Residues 602-853 are 28% similar to a (PHOSPHOPANTETHEINE G01D9.5 C41A3.1 09D6.1) protein domain (PD360048) which is seen in Q18559_CAEEL.Residues 423-500 are 41% similar to a (SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD414840) which is seen in P94459_BACSU.Residues 242-389 are 25% similar to a (PROTEOME COMPONENT F-RELATED COMPLETE) protein domain (PD313684) which is seen in Q9KRQ7_VIBCH.Residues 740-804 are 32% similar to a (ATP-DEPENDENT ACTIVASE ADENYLASE) protein domain (PD394292) which is seen in BACA_BACLI.Residues 415-476 are 50% similar to a (SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD299811) which is seen in Q9R9J0_BACSU.Residues 415-503 are 41% similar to a (SYNTHETASE PHOSPHOPANTETHEINE ADENYLASE) protein domain (PD396086) which is seen in O30980_BACSU.Residues 244-294 are 43% similar to a (LIGASE SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD000102) which is seen in O52819_BBBBB.Residues 739-804 are 45% similar to a (PHOSPHOPANTETHEINE SYNTHETASE PEPTIDE ATP-DEPENDENT) protein domain (PD000113) which is seen in Q44928_BACBR.Residues 369-450 are 30% similar to a (MCYB PHOSPHOPANTETHEINE) protein domain (PD396892) which is seen in Q9S1A8_MICAE.Residues 400-514 are 26% similar to a (ATP-DEPENDENT ACTIVASE ADENYLASE VALINE) protein domain (PD395777) which is seen in GRSB_BACBR.Residues 511-580 are 45% similar to a (SYNTHETASE PHOSPHOPANTETHEINE LIGASE) protein domain (PD000107) which is seen in P94459_BACSU.Residues 619-689 are 40% similar to a (LIGASE SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD000081) which is seen in BACA_BACLI.Residues 234-501 are 23% similar to a (PHOSPHOPANTETHEINE G01D9.5 C41A3.1) protein domain (PD034003) which is seen in Q17301_CAEBR.Residues 826-898 are 36% similar to a (SYNTHETASE PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD000236) which is seen in Q45675_BACSU.Residues 369-450 are 30% similar to a (PHOSPHOPANTETHEINE REDUCTASE) protein domain (PD034004) which is seen in Q9RNB0_MICAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 4 14:52:54 2002","Tue Oct 22 16:22:46 2002","Tue Oct 22 16:22:46 2002","Mon Mar 4 14:52:29 2002","","Mon Mar 4 14:52:29 2002","yes","Tue Oct 22 09:18:04 2002","SMu1224 is paralogously related (blast p-value < 1e-3) to SMu1225, a predicted bacA sequence, to SMu1223, also a predicted bacA sequence; and to SMu1222, SMu1226, SMu1541, and SMu1228.","Wed Oct 23 10:01:45 2002","Mon Mar 4 14:52:29 2002","pdb|1AMU|B Chain B, Phenylalanine Activating Domain Of Gramicid... 254 5e-068","SMU.1341c","","Residues 256 to 654 (E-value = 2.9e-98) place SMu1224 in the AMP-binding family which is described as AMP-binding enzyme (PF00501)Residues 738 to 802 (E-value = 2e-16) place SMu1224 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)Residues 820 to 1104 (E-value = 2.8e-55) place SMu1224 in the Condensation family which is described as Condensation domain (PF00668)","Mon Mar 4 14:52:29 2002","24379753","","","Saito,F., Hori,K., Kanda,M., Kurotsu,T. and Saito,Y.Entire nucleotide sequence for Bacillus brevis Nagano Grs2 geneencoding gramicidin S synthetase 2: a multifunctional peptidesynthetaseJ. Biochem. 116 (2), 357-367 (1994)PubMed: 7822255","Wed Oct 23 10:01:45 2002","Mon Mar 4 14:52:29 2002","1","","12","SMU.1341c","" "SMu1225","1281023","1272849","8175","ATGGAAATTTTATTTGAGCAAAATGAAACGAGAAATATTGAAAAAATAACAAAAAAAGATCCTTTATTGACGCAGATTCTTTTTTCATCGCTCATAAAAATGATAACTTTTAAAAGATATGGAGAAATAGGATTTGATACGGGTATTGTAATGGACGGTCAGAAGCTGGTACTTTTAGAGTCGGAAAACATGGATCCACAACAAACCCTTAAACAAATTATTTTGGAAGAAAGGGAGATTATACTAAAGAATAATCAATCATTTCTTAGGAAAAATGTTACAAATGATATTTTTCAAAGGTATATCATTGATTTTAGAAAAAAGAAAGCTAGTTCTATTAATGATGAACATAGCAAGAATAATGTATATTTAAATTTTTATTATCAATTAGACATGCTGAATTGTAGTATAACTAATTCAGAAAATGAAGAGAATGGTCTTTCTGAAATGTTTCATTTGATAAAAACAGTTATATCTGAACTCCCTCAAAATATTAATCAGAAGATTAAGGATATTGCTTTAATCACAAATGAAGAAAAAGAAAGTATTTTAAAGATATCAAGGGGCAAAGAATTATCAATTGAAGCTCCAACCTTTTTAAAGTTATTTCAAAAAGTTACTGATAGATTAAAAAACAAAGTAGCTATTTCGTCAGATGATTGGTATTTAACTTATGAACAACTTAATCAGGAATCAGAGAAACTTTCTCTTTATTTAAGTAAACTCTTTGAGCCAAAAAGTATTGTTCCCTTGGTGATGGATAATAGTTCAGAAATGTTTATTGTTATTTTTGCCATATTGAAAAGTGGTTTTGCTTTCTCACCCATTTCTTTAGATTATCCTCCAGAAAGAATAGAGCATATTATAAAAGAAACTCATTTAAATAGTGTTATTGTTCCAGAAGAAGCTAATCTTCAAATTTCTAAGGAAATAAAACAATATGTAGCTAAAGATTTGTTAAATAAAGCTCCAGTTGAAGTAGATCAATTTTCAAATGCTGTAAATGTAAGAGGAGACGACATTGCTTATGTTATTTTTACATCAGGGACAACAGGAACACCTAAAGGAGTAAAAGTTTCTCATCAATCATTGATGAATCTCATTACTTGGCATAATGATAATTTCTCAATAACTTCTGAAACTATAGCTGCTAAATACGCTGGTGTGGCTTTTGATGCAAGTATTTGGGAATTATTTCCTTATTTATCAATTGGAGCAAAAGTTTATGTTGTTTCAGAAAAAGATCGTTTTGATGTTAAAAAATTAAATCAAAAATTTATTGAAAATAAGGTTAGTATTGCTTTTTTACCCACAGTAGTCTTTGAAAAATTTAGCAAGGTGCAAAATCCATATTTGAAAATTCTTTTAACCGGTGCAGAAAAGCTACACTATTTTTCAGAACAAGCTTACGAACAATATAATAATTACGGTCCAACAGAGTATACTGTTGTAGCCACATCTTTCAAGTTAGAAAAACACATGGATAATATACCAATTGGTAAACCTATCGCCAATACAACTGCTTTAGTAATGTCAAATGATCGTCACTTTCTCCCCATTGGTTTTAAAGGTGAACTATATTTGGGAGGAGATAGTTTATCTTCTGGTTATTTAAATGATTCTAAAAAGACAAAAAATAGTTTTATTGAATTAGAACAAATTATGGGACAAGTTTTTTACAAAACAGGAGACTTAGTTGCATATACTGATAGTGGTGAGTTACTTTATTATGGAAGAATTGATAATCAAATTAAAATTAATGGATATAGAATAGAACTTCAGGATATCGAAAAAAATATATTAGAAATAATAGGACAGGATTCAGATTGTTCTGTTGTTGTTATTCCAGTCTCTATTAATGGCTTAATATCTCTTCATGCATTTTATGAAGGAGTTACGGGATTTGACTCTAATCCTAATCAAGTCTTAAAACAACTTACAAATAAATTACCTTCATATATGGTTCCTAGTACTATTGAGTCTTTGTCACAATTTCCTTTAACTTCTAACGGAAAGGTTGATCGAAAATATTTGGAAAAAATAGTACTAAATAAATCGACATCTGTTAAAGAAATTAATAATGATAATCCTTTATTAGTTAAAGTAATGAAAATTATTACTGAGATTTTAAAAGGTAGACAAATTAATCCTGATGAAGATTTTTTCCAAATGGGTGGAAATTCTTTAACTGCTATTGAATTAGCCAATAAATTACAAGAAGAACTAAATAAAAAAGTAACAATTGATGATATATTTAAATTTAGAAATGCTATTAACCTTGTTGATAATTTAACAAATAGGGAAAACTTAAAACCGCTAGAAACTAGTATCCAATCTTCGGAGGAGATTTCTTATGAATCAAGTCCAAGTCAAAAAGCAATTTTTATTGAACAAAAGATTGATGAGAAGTCTTTGGCATATAATATGCCAATTGTTTACAAAATTAATGGAGAAATAGATTTTGAAAAATTGGAATCTAGTTTGGACAAAGTAGTAAAAAATAATGAATTATTAAGATCTCACTTTTATTTAAAAGATGAGCGTGTTATGGTAAAAACCCCTAAGGTAAAAGATTATTATCATGTTATGGAAAGGAAAGAGCTTAGTGAAAAATCTTTTGATTTAACAAAGGAATTTAAAAAATTTGTACGCCCATTTAATCTTGAAAAAGATGTTCTTATCAGAGCGAAAATAATAAAAACTTCGTCTCAAAAATATCTCTTTTTAGATAGCCATCATATTTCTTTTGATGGGGGAAGCTTGAATCCCTTTATTAATGATTTTAAAAAGGCATATGCAGGAGTAGAACTTGAAAGAAAAGCTTCGTATAGTCAATATGCTTTACAAACACTATCTCCTCATTTCTTAAAAGCAAGTCATTCACATTTTGAAAAGGAATTTGGAACACTTGTGGAGCCACTAAAATTATCTGATTTTGGAACTATTGATCATCAAAAAAAGGCTGGTGTGAGTTTCGATAGTGAATTTTCTTATAAGATAAGAAATATCGCTTTGAAAAATAAGGTAACAGTATTTAATCTGTTGTTTTCAATTGTTGGATATTTACTCAGTTGTTTTTCAAATCAAAAAGATATTTGTATAGGTGTTCCAGTAACAAATAGAAATAGAAGTCAGTATAAAAATATTATTGGTATGTTTGTTAATACTCTACCTGTTAGATTGAATTATGAAAATTTACATACAGTTGAGGAAATGAATAAATATGTAAATAATCAATTTATCGAAGCTTTAAAATATAAAGAATTTTCTTTAGAAGAAATTATTAAAATTAGTAGAGACAAAACAGAAAATGATATTAGCCAATTATTTAATGTACTATTTGTAATGAATGAAATTGAAGATTTTAATTTTTCTATTGATAATACAACTTTCGAGAAAATGTCTGCTGATAATAAAGATGTGAAATACGATTTGTTATTTGAAGTTTTAGATAATACAAAGGATAATACTTTTTCAATTTCTTTAGAATATGATAATAAAAAATATTCGAACCAATTAGCAAATAGACTATTACAAAGTTTGCAAAAGATTTTGATGGAAGTAGTTGACAAGCAAAAAAATAATTTATCGGATATTAAAATTATTTCTGAAATAGAGGAACAGACACTACAATCATTTCTAACGTGGAAGCAATTTACAGGAAAACAGCAAAAACTCCATGAACCCTTTGAAAATTTAGTCAAGCAATTTCCTAATAAGATTGTTGTTAAAGATAAAAATACTTCAATGACTACAACCGAACTTATGCAGAAATCGAATATTGTTGGTAATTTTTTACAAAGACAAGGAGTGAATAACAATAAAAAAGTTGCTATTATTGTTAATAAATCAGTAAATATGATGGTAACTATACTAGGTGTTCTAAAATCTGGTGCAGCTTATGTTCCTATTGAACCGTCTTTACCAGAGGAGAGAGTGAAATACATTTTAGATGACTCCTGTTGTGACTTCATTATTAGTGAGGAACCATTTTATAATGGAAAGATTAATTCTGAAACAATATCAAATATTCTAAATGAAGAACCAGATATTTCTAAAGTTGAATCAGACAGTACCTATAAAGATCTGTGTTATATCATCTATACCTCTGGTTCGACAGGAGATCCTAAAGGAGTTATGCTAACCCATGAAGCTGTTATGAATCGATTGCTATGGATGCAAAATGCTTATCCAATTACAAAGAATGATATAATTTTGCAAAAAACTTCATTTGGTTTTGATGTATCTATTTGGGAATTATTTGGCTGGACTTTTGAAGGTGCAGTATTATATTTTTTAGAAAATGGAGAGGAAAAAGATCCTCAAAGGATTATTGAGTTAATAAATAGCCAAAATATTTCAAAACTTCATTTTGTTCCATCAATGTTAAATGTATTTCTTGAATTTTGTGAGAGAGAAAACAAAGATTCTTTAAAAAGTCTTAGCATAGTTTTTTCGAGTGGAGAAGCACTGACAAAAGAACAAGTAATCAAGTTTTATAGTATTTTTGACAACGACAAGCCTCAATTAATTAATTTATATGGCCCAACTGAAACAGCAATTGAAGTAACTTATTTTGATTGTAGTAATCTTGATTATAAATCTGAAGATGTTCCAATTGGAGAACCTTTGGATAATGTTGAAGCTTATGTTCTTAATGATAAAAAACAAAAATGTCCTATCGGTGTTGTTGGGGAACTGTATATAGGAGGAATACAGGTAGCTCAAGGATATATTAACAAAGAAGATGCTACAAAGAAATCTTTTGTGAGACTACCGAAAATTTCAAATTCAAGATTATATGCTACAGGTGATTTAGTAAAATGGACTTCAGAAGGGAAGTTAATATTCATTGGTCGTTCTGATGATCAAGTTAAAATTCGAGGTTATCGAATTGAATTGGGTGAAATTGAAAAATATTTGAAGAAAGTAAGCCAAAAGAACTGCTTGGTAAGCCTTCAAAATAAACTTTCAAAAAATAATAAGAGCCTCATTGCTTATATTGAAAGTTCAACAACTATTGATGAAAGCAAGATCAAAGAAGAACTTAAGACTTTATTACCTCAATATATGGTTCCAAGTCACATTTATATTGTCCCAGAATTTCCTATAAATAAAAGTGGTAAAGTGGATAGGAAGTTACTTGATAGTATGTATTCGTCAAAACATATTGCTCCTAAGGAAGGTCTTATTAAATCAAGTAATTTAACAGAAGATATTAAATCTGTTTGGAGTAATATATTAGATTATTCCATTGATTCTTTTTCAGAAGATGATAATTTTTTCTCTCTTGGAGGAGACTCTATTAAAGCTATTAGTATGGCTTCGAAACTCATTTCCAAAGGGTATAAAGTTTCAGTTAAAGAAATTTTGAAAAATCCAACGATAGCTCAACTTACAAAAATAGTAGTTAAGTCTAATCAAATCGAAGAAGATTCGGAACTTGATAATAGTGTCCCATTAACTCCGATTAGTCAATGGTTTTGGAAACAAAATTTTCAAGTGCGAACTCATTGGAATCAAGCTGTAGTACTTGTGAGTAAAGATAAAATAAATGATGAATTTTTAAGAATAGCTATAGAAAAAATCATTGATGAGCATACTATATTAAGGAGTCAACTTGACAATAATTCGTTATCAATTGACAATCAAAAAGACGCTCAACGATTTTATGATTATCAAGAAATTGATATTTGTGGATGGGATGATAAAGCAAAGATCATTAATAGCTATGTATATAATATTTTATCTAAATCTTCAAAGTTAATAAATATTGTTAAATTCATTTGTGATGATTGTGAAAGAATCGTGCTTTCAATTCATCATCTTTTGATAGATACAATTTCGTGGAAAATACTTATAGAAGATTTTTGTAGTTATTATGGACAACTTAGAAATGGACAGTCATTAAATTCAAGTTTTAAAACAACTTCATTTATTACTTGGGCTAATAGAATAAACACGTTATCTGTTAAGTTTTCTGAAAGTAATATGGAAAAGAAGTATTGGGATAATATTGTGCAAACGCCTGTCGATTTAATTAATCAAGATGGTGTTATTAATCCAGGAAGTATCAAGGATAGAAAACATTCTAGAATAAAATTGGAAAAAGAAATCAGCTCTCAACTATCAGATATATCAGTATCAAATTCCCATGTTACCCAGGAGCATATTCTTTTGACAAGTGTTTTAATGGCTTTAAAGAAAAGTTATTCTATTTCAAATATTCCTATTTTAATGGAAGGATATGGTCGTGAAGAGTACCTTACTCAAACCACTTTAGCGAGAAGTATAGGATGGTTTACTAATACTTATCCGCTTGTTTTTAAAGTCAAGGATGATGTTTTACAAACATTAATTCAAGTTAAAGATATCATTAATAGGGTGCCTCATAATGGTATTGGCTATGGATTACTCCATTTGGTAAATAGTAATTTACAAGATTTAGATCCTGAAATTAGTTTTAACTTTTTGGGAGAAATAAGTAGTGAATCAAGTACACAATTCATGACTTTGGACAATATTGAGTTAGATTGTTTAATAAATAAGTCAAATAGTAATCCATATCTTATTGAATTTTCAGTATTTTTCTTAAAGGGAGAACTATTCGTAGATGTTTATTTTGACAGCACGTTAATTAGTCAAGAAGATGTGGAAATAATGAATCAGAATTTTGTGCAAACAATAAATGAGCTGATAAATTGTTCAGAAGATATATCAACAATGCGAAGTATTTCTGATGTTACAAATGAAACATTTAAATATGAAAGTAACAATTTACCTATTGTTAATGATAAAAATATTGATAAAATTAGAAAAACATTACCAATGCAAAGTAATATTTTGTTTCTTGAACAATTTCAAAAAAATAGAAATATTTATCATGAACAATTTAAAGTAGACTTTAAAGGTAGACTGAATAAAAAAATTTTTGATAAAGCTGTGCAATTTGTAGTAGATCAGTACGAAGCTCTAAGGACTAGTTTCGATTTAACTACATTTGGTGAGCCTGCTCAAATTATTAAACAAAATAATACAATTAGTATAGACGCTTATACATTTGAAAGCCCAAGACAGGATAGTGAAGCTGCTGTTAAGAAATTAGAAAATGAATTCTTAGATATCCCATTTGATACTCAGGAATCAGATCTGTTTAGAATTACTATTTTAGAATTTAAAGACCAAGAAGTCAGTTTAATTTTTGACTATCACCATATAATTTTGGACGGTTGGTCAATGTTGATTGTTTTACGTAAAATATTCACCTGTTATACTAAGCTTTTGAAGGATGCAACCTATATAAATGAAGAAGAAAACATAAATATAGATGATTACTTTGATTATAAAGATTTATTTGAAACTGAATCAGCTAAAAGATATTGGAAAAATTTCTTAGAAAACATTGGTGAGAATTTAAATTTAGAAAATTACTTTGATAGAAATCTTGAGGGAAAAACGATTGAACATAATATTGGTGAATATAGATTCTCAATATCAAAACAACAAGATAAACAAATCAGACAATTTTGTGAAAATTTAAACTGTACTACAAATGATTTTGCTCATTTAATTTGGTCAACCATATTATATAAATATTTAAAGAGTCAATCACAAGTATTTTTCTATACTGTTTCAGGTCGAGATGGAGATATTAATATTGAAAATGAAGTTGGACTTTTTATAAATACTATTCCTCAAGTGACTAATATCAATGATGATAGTAGTATATCAAGTATAGTCGAAAGTATTCATTTAAATATTTCTAATGCATTTGGCTATTCACAATTGCCTCTAAGTGAGATTTTACAACAATCACAAGTTTCTCATGATCAGATTAATACACTTTTGGTTTATGAAAATTTTCCTATCCATAAAGATGATTTTATAGCAGAATTGTCAGATTCTCAATTGGAATTTCAAACTTATAAAGCAACTGAAGCTACAACGTATGACTTGACTCTTATCTTTTCTGAGGAAGAAGAGAAGATTTCTATTCGTATACTCTATAATCCTCATAAATATAGTAATCAGTATATTTCGATTCTAGGAAAAAATATCCAAGGAATTATTGATGATTTAGTCACTAAAAATTATTTCCGTGAGATTACTCTTCCAGATAATACTTTCAATGAGGCTTTACAGTCGGTAGAAGATAAACTAGACTTTAATTTTTAA","5.20","-61.43","313658","MEILFEQNETRNIEKITKKDPLLTQILFSSLIKMITFKRYGEIGFDTGIVMDGQKLVLLESENMDPQQTLKQIILEEREIILKNNQSFLRKNVTNDIFQRYIIDFRKKKASSINDEHSKNNVYLNFYYQLDMLNCSITNSENEENGLSEMFHLIKTVISELPQNINQKIKDIALITNEEKESILKISRGKELSIEAPTFLKLFQKVTDRLKNKVAISSDDWYLTYEQLNQESEKLSLYLSKLFEPKSIVPLVMDNSSEMFIVIFAILKSGFAFSPISLDYPPERIEHIIKETHLNSVIVPEEANLQISKEIKQYVAKDLLNKAPVEVDQFSNAVNVRGDDIAYVIFTSGTTGTPKGVKVSHQSLMNLITWHNDNFSITSETIAAKYAGVAFDASIWELFPYLSIGAKVYVVSEKDRFDVKKLNQKFIENKVSIAFLPTVVFEKFSKVQNPYLKILLTGAEKLHYFSEQAYEQYNNYGPTEYTVVATSFKLEKHMDNIPIGKPIANTTALVMSNDRHFLPIGFKGELYLGGDSLSSGYLNDSKKTKNSFIELEQIMGQVFYKTGDLVAYTDSGELLYYGRIDNQIKINGYRIELQDIEKNILEIIGQDSDCSVVVIPVSINGLISLHAFYEGVTGFDSNPNQVLKQLTNKLPSYMVPSTIESLSQFPLTSNGKVDRKYLEKIVLNKSTSVKEINNDNPLLVKVMKIITEILKGRQINPDEDFFQMGGNSLTAIELANKLQEELNKKVTIDDIFKFRNAINLVDNLTNRENLKPLETSIQSSEEISYESSPSQKAIFIEQKIDEKSLAYNMPIVYKINGEIDFEKLESSLDKVVKNNELLRSHFYLKDERVMVKTPKVKDYYHVMERKELSEKSFDLTKEFKKFVRPFNLEKDVLIRAKIIKTSSQKYLFLDSHHISFDGGSLNPFINDFKKAYAGVELERKASYSQYALQTLSPHFLKASHSHFEKEFGTLVEPLKLSDFGTIDHQKKAGVSFDSEFSYKIRNIALKNKVTVFNLLFSIVGYLLSCFSNQKDICIGVPVTNRNRSQYKNIIGMFVNTLPVRLNYENLHTVEEMNKYVNNQFIEALKYKEFSLEEIIKISRDKTENDISQLFNVLFVMNEIEDFNFSIDNTTFEKMSADNKDVKYDLLFEVLDNTKDNTFSISLEYDNKKYSNQLANRLLQSLQKILMEVVDKQKNNLSDIKIISEIEEQTLQSFLTWKQFTGKQQKLHEPFENLVKQFPNKIVVKDKNTSMTTTELMQKSNIVGNFLQRQGVNNNKKVAIIVNKSVNMMVTILGVLKSGAAYVPIEPSLPEERVKYILDDSCCDFIISEEPFYNGKINSETISNILNEEPDISKVESDSTYKDLCYIIYTSGSTGDPKGVMLTHEAVMNRLLWMQNAYPITKNDIILQKTSFGFDVSIWELFGWTFEGAVLYFLENGEEKDPQRIIELINSQNISKLHFVPSMLNVFLEFCERENKDSLKSLSIVFSSGEALTKEQVIKFYSIFDNDKPQLINLYGPTETAIEVTYFDCSNLDYKSEDVPIGEPLDNVEAYVLNDKKQKCPIGVVGELYIGGIQVAQGYINKEDATKKSFVRLPKISNSRLYATGDLVKWTSEGKLIFIGRSDDQVKIRGYRIELGEIEKYLKKVSQKNCLVSLQNKLSKNNKSLIAYIESSTTIDESKIKEELKTLLPQYMVPSHIYIVPEFPINKSGKVDRKLLDSMYSSKHIAPKEGLIKSSNLTEDIKSVWSNILDYSIDSFSEDDNFFSLGGDSIKAISMASKLISKGYKVSVKEILKNPTIAQLTKIVVKSNQIEEDSELDNSVPLTPISQWFWKQNFQVRTHWNQAVVLVSKDKINDEFLRIAIEKIIDEHTILRSQLDNNSLSIDNQKDAQRFYDYQEIDICGWDDKAKIINSYVYNILSKSSKLINIVKFICDDCERIVLSIHHLLIDTISWKILIEDFCSYYGQLRNGQSLNSSFKTTSFITWANRINTLSVKFSESNMEKKYWDNIVQTPVDLINQDGVINPGSIKDRKHSRIKLEKEISSQLSDISVSNSHVTQEHILLTSVLMALKKSYSISNIPILMEGYGREEYLTQTTLARSIGWFTNTYPLVFKVKDDVLQTLIQVKDIINRVPHNGIGYGLLHLVNSNLQDLDPEISFNFLGEISSESSTQFMTLDNIELDCLINKSNSNPYLIEFSVFFLKGELFVDVYFDSTLISQEDVEIMNQNFVQTINELINCSEDISTMRSISDVTNETFKYESNNLPIVNDKNIDKIRKTLPMQSNILFLEQFQKNRNIYHEQFKVDFKGRLNKKIFDKAVQFVVDQYEALRTSFDLTTFGEPAQIIKQNNTISIDAYTFESPRQDSEAAVKKLENEFLDIPFDTQESDLFRITILEFKDQEVSLIFDYHHIILDGWSMLIVLRKIFTCYTKLLKDATYINEEENINIDDYFDYKDLFETESAKRYWKNFLENIGENLNLENYFDRNLEGKTIEHNIGEYRFSISKQQDKQIRQFCENLNCTTNDFAHLIWSTILYKYLKSQSQVFFYTVSGRDGDINIENEVGLFINTIPQVTNINDDSSISSIVESIHLNISNAFGYSQLPLSEILQQSQVSHDQINTLLVYENFPIHKDDFIAELSDSQLEFQTYKATEATTYDLTLIFSEEEEKISIRILYNPHKYSNQYISILGKNIQGIIDDLVTKNYFREITLPDNTFNEALQSVEDKLDFNF","1272864","For other 'bac' genes see SMu0221 (bacA); SMu1223 (bacA2); SMu1222 (bacD) and SMu1229 (bacT).","bacitracin synthetase","Cytoplasm","Significant hits in gapped BLAST to gi|5915760 BACA_BACLI Bacitracin synthetase 1 (BA1) [Includes: ATP-dependent isoleucineadenylase (IleA) (Isoleucine activase); ATP-dependentcysteine adenylase (CysA) (Cysteine activase);ATP-dependent leucine adenylase (LeuA) (Leucineactivase); ATP-dependent glutamate ad>: Residues 127-2107 are 28% similar to residues 2054-4622. Residues 19-2702 are 27% similar to residues 303-2971 of BACC_BACLI.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1790 (7e-47).","

InterPro
IPR000873
Domain

AMP-dependent synthetase and ligase
PR00154	$\"[1361-1372]T$ $\"[1373-1381]T$	AMPBINDING
PF00501	$\"[224-612]T$ $\"[1251-1651]T$	AMP-binding
PS00455	$\"[344-355]T$ $\"[1366-1377]T$	AMP_BINDING

InterPro
IPR001242
Domain

Condensation domain
PF00668	$\"[781-1064]T$ $\"[1815-2112]T$ $\"[2276-2571]T$	Condensation

InterPro
IPR006162
PTM

Phosphopantetheine attachment site
PS00012	$\"[723-738]?$	PHOSPHOPANTETHEINE

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[700-764]T$ $\"[1738-1803]T$	PP-binding
PS50075	$\"[698-765]T$ $\"[1736-1804]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[696-774]T$ $\"[1722-1813]T$	ACP_like
SSF47336	$\"[691-766]T$ $\"[1729-1805]T$	ACP_like

InterPro
IPR010071
Domain

Amino acid adenylation
TIGR01733	$\"[1251-1651]T$	AA-adenyl-dom

noIPR
unintegrated

unintegrated
G3DSA:2.30.38.10	$\"[499-579]T$ $\"[1538-1618]T$	G3DSA:2.30.38.10
G3DSA:3.30.300.30	$\"[581-692]T$ $\"[1627-1715]T$	G3DSA:3.30.300.30
G3DSA:3.40.50.980	$\"[194-362]T$ $\"[363-498]T$ $\"[1221-1384]T$ $\"[1385-1536]T$	G3DSA:3.40.50.980
PTHR11968	$\"[1222-1765]T$	PTHR11968
PTHR11968:SF36	$\"[1222-1765]T$	PTHR11968:SF36
SSF56801	$\"[161-685]T$ $\"[1188-1745]T$	SSF56801

","BeTs to 4 clades of COG1020COG name: Acyl-CoA synthetases (AMP-forming)/AMP-(fatty) acid ligases IFunctional Class: IThe phylogenetic pattern of COG1020 is ----y---eBR----------Number of proteins in this genome belonging to this COG is 4","***** IPB000873 (AMP-dependent synthetase and ligase) with a combined E-value of 1.4e-09. IPB000873A 1368-1383 IPB000873A 346-361","Residues 1064-1259 are 27% similar to a (MEROZOITE SURFACE PRECURSOR SIGNAL) protein domain (PD005070) which is seen in MSP1_PLAFW.Residues 1510-1718 are 21% similar to a (U26 PEPTIDE SYNTHETASE) protein domain (PD361102) which is seen in Q9VLL0_DROME.Residues 2496-2607 are 34% similar to a (SYNTHETASE PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD000924) which is seen in O30980_BACSU.Residues 403-470 are 41% similar to a (PHOSPHOPANTETHEINE SYNTHETASE SURFACTIN) protein domain (PD400086) which is seen in Q45675_BACSU.Residues 1297-1388 are 30% similar to a (SIX-DOMAIN PEPTIDE NONRIBOSOMAL) protein domain (PD291056) which is seen in Q9FDB0_VIBCH.Residues 1936-2003 are 39% similar to a (PHOSPHOPANTETHEINE SYNTHETASE PEPTIDE) protein domain (PD190717) which is seen in Q9R9J0_BACSU.Residues 1291-1329 are 56% similar to a (SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD091375) which is seen in BACC_BACLI.Residues 1399-1491 are 30% similar to a (SYNTHETASE PROTEOME NON-RIBOSOMAL) protein domain (PD414629) which is seen in Q9I157_PSEAE.Residues 2058-2161 are 38% similar to a (SYNTHETASE PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD365049) which is seen in BACB_BACLI.Residues 1583-1683 are 28% similar to a (PHOSPHOPANTETHEINE) protein domain (PD198495) which is seen in O94205_CLAPU.Residues 1740-1803 are 43% similar to a (PHOSPHOPANTETHEINE SYNTHETASE PEPTIDE) protein domain (PD000113) which is seen in O66069_BACLI.Residues 1362-1468 are 31% similar to a (MCYB PHOSPHOPANTETHEINE) protein domain (PD396892) which is seen in Q9S1A8_MICAE.Residues 1503-1553 are 50% similar to a (PHOSPHOPANTETHEINE SYNTHETASE ADENYLASE) protein domain (PD366599) which is seen in TYCC_BACBR.Residues 1397-1491 are 45% similar to a (LIGASE SYNTHETASE COMPLETE PROTEOME ACETYL-COENZYME) protein domain (PD000070) which is seen in Q9I179_PSEAE.Residues 1363-1420 are 41% similar to a (PHOSPHOPANTETHEINE PEPTIDE SIDEROPHORE) protein domain (PD204212) which is seen in SID2_USTMA.Residues 1811-1871 are 33% similar to a (SYNTHETASE PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD000236) which is seen in BACB_BACLI.Residues 197-441 are 22% similar to a (AMINO ACID-ADENYLATING ENZYME) protein domain (PD204214) which is seen in Q52379_PSESG.Residues 1936-2004 are 40% similar to a (ATP-DEPENDENT ADENYLASE ACTIVASE) protein domain (PD331154) which is seen in PPS2_BACSU.Residues 1427-1499 are 41% similar to a (PHOSPHOPANTETHEINE SYNTHETASE PEPTIDE) protein domain (PD403805) which is seen in Q9HYR8_PSEAE.Residues 519-572 are 46% similar to a (LIGASE SYNTHETASE COMPLETE PROTEOME) protein domain (PD007428) which is seen in BACA_BACLI.Residues 1598-1808 are 31% similar to a (PHOSPHOPANTETHEINE G01D9.5 C41A3.1 09D6.1) protein domain (PD360048) which is seen in Q18559_CAEEL.Residues 1365-1397 are 69% similar to a (PHOSPHOPANTETHEINE SYNTHETASE ATP-DEPENDENT ADENYLASE) protein domain (PD265446) which is seen in Q9FB23_BBBBB.Residues 1235-1521 are 20% similar to a (F25C8.4) protein domain (PD279081) which is seen in Q9XV68_CAEEL.Residues 1679-1810 are 25% similar to a (DOMAIN OF UNKNO N) protein domain (PD323793) which is seen in Q9GM05_MACFA.Residues 1690-1890 are 24% similar to a (ATTACHMENT PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD295480) which is seen in Q9P7T1_SCHPO.Residues 519-681 are 26% similar to a (AM-TOXIN PHOSPHOPANTETHEINE SYNTHETASE) protein domain (PD316667) which is seen in Q9UVN5_ALTAL.Residues 405-462 are 46% similar to a (SYNTHETASE ATP-DEPENDENT) protein domain (PD186447) which is seen in O69246_BACLI.Residues 1691-1814 are 31% similar to a (PHOSPHOPANTETHEINE PEPTIDE SYNTHETASE) protein domain (PD187474) which is seen in O94116_AURPU.Residues 337-368 are 75% similar to a (SYNTHETASE PHOSPHOPANTETHEINE LIGASE) protein domain (PD296195) which is seen in Q9RLP6_MYCSM.Residues 2076-2131 are 41% similar to a (PHOSPHOPANTETHEINE SYNTHETASE) protein domain (PD038697) which is seen in SRF1_BACSU.Residues 2076-2130 are 42% similar to a (SYNTHETASE PHOSPHOPANTETHEINE LIGASE) protein domain (PD297982) which is seen in GRSA_BACBR.Residues 1496-1581 are 48% similar to a (SYNTHETASE PHOSPHOPANTETHEINE LIGASE) protein domain (PD000107) which is seen in O31827_BACSU.Residues 1617-1690 are 44% similar to a (LIGASE SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD000081) which is seen in Q9R9I9_BACSU.Residues 1160-1430 are 23% similar to a (PHOSPHOPANTETHEINE G01D9.5 C41A3.1) protein domain (PD034003) which is seen in Q17301_CAEBR.Residues 1392-1491 are 29% similar to a (LIGASE CARRIER D-ALANINE-D-ALANYL ENZYME) protein domain (PD204220) which is seen in Q9PMZ2_CAMJE.Residues 1931-2015 are 36% similar to a (SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD313120) which is seen in ACVT_PENCH.Residues 1362-1468 are 28% similar to a (PHOSPHOPANTETHEINE REDUCTASE) protein domain (PD034004) which is seen in O74298_PENCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 23 09:55:01 2002","Mon Mar 4 14:58:39 2002","Tue Oct 22 17:06:11 2002","Mon Mar 4 14:58:39 2002","Mon Mar 4 14:58:39 2002","Mon Mar 4 14:58:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1225 is paralogously related (blast p-value < 1e-3) to SMu1223, a predicted bacA; to SMu1224, a predicted gramicidin S synthase; and to SMu1222, Smu1541, Smu1226, Smu1228.Residues 198-1804 of Smu1225 are 28% similar to residues 19-1623of Smu1223. ","Wed Oct 23 09:55:01 2002","Mon Mar 4 14:58:39 2002","pdb|1AMU|B Chain B, Phenylalanine Activating Domain Of Gramicid... 272 5e-073pdb|1BA3| Firefly Luciferase In Complex With Bromoform >gi|20... 71 1e-012","SMU.1342c","","Residues 224 to 615 (E-value = 3.7e-92) place SMu1225 in the AMP-binding family which is described as AMP-binding enzyme (PF00501)Residues 700 to 764 (E-value = 1.3e-12) place SMu1225 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)Residues 781 to 1064 (E-value = 4.1e-31) place SMu1225 in the Condensation family which is described as Condensation domain (PF00668)Residues 1251 to 1651 (E-value = 7.2e-127) place SMu1225 in the AMP-binding family which is described as AMP-binding enzyme (PF00501)Residues 1738 to 1803 (E-value = 1.1e-11) place SMu1225 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)Residues 1815 to 2112 (E-value = 8.5e-10) place SMu1225 in the Condensation family which is described as Condensation domain (PF00668)Residues 2271 to 2571 (E-value = 6e-38) place SMu1225 in the Condensation family which is described as Condensation domain (PF00668)","Mon Mar 4 14:58:39 2002","","","","","Wed Oct 23 09:55:01 2002","","1","","12","SMU.1342c","" "SMu1226","1284383","1281069","3315","ATGTCAATAAAAGTTGCACAAGCAGAAAACTTGGAAGAATTCTGGGATCTATTGAAAGAAGGAAAAGAAACTATATCTTCTTTCCCACAACAAAGAAGTAAAGATGTACATATATTGGAGAATAATAATATGAAATTTGAAGTGGGTTCTTATTTAGAAGATATTGCTTCTTTTGATCCTTATTTTTTTAATATAACTCCTAGAGAAGCAGAATTGATGAGCCCTATTCAAAGATTAACTTTGGAAAAATGTCTAGAAGCTCTAGATGATGCGGGTATTAGCAAAAAGACTTTAAATGATTCTAAAACAGGAATTTATCTCGGCCATATTGGAGATTTAGAGGGCTATAAATATAAAAACTGGGTTAACAAATTTTATAATAACGATCCAATGGCCATTCCAGGAAATTTGAATTCAATTATTCCTAGTCGAATATCGTATGTCCTCAATTTAAAAGGTCCAGCTGTTTTAATTGATACAGCATGTTCTTCTTCACTCGTAGCGATTAGTGAAGCGTGTAAGAGCATCACCAATAAAGAATGCGATATGGCTATTGCTGGGGGAATTCGCATCTCTTTTTGTCCAGAAACAAGTTCAGAAAAATTAGGAATAGAATCTAGCAATAGGCAGACTAGGCCATTTGATTCTGAAGCAGATGGTACAGTCCTTGGTGAAGGAGTAGGAATTGTCGTTTTAAAACGATTGGCAGATGCAATAAAAGATGAAGATCACATCTATTCGGTAATAAAAGGAGTAAATGTAAACCAAGACGGCTCATCTGCAGGAATTACTGCACCAAATGGTAAAGCACAGGTGGATTTACTGACAGAATTATGGAAAAAGTATGATATTAACCCACAAGATATTGATTATATTGAAGCACATGGAACAGGAACAAAGCTTGGAGATCCTATCGAAATAAAAGCATTAACTCAAGCAGTATCTAAATTTACACGTAGGAAACAATTTTGTGGTATTGGATCAGTAAAATCAAATATTGGTCATTTATTTGAAGCCGCAGGTGTTATTTCAGTAATTAAAACAGCCTTAATGATTGAGAAACAGCATTTAGTTCCTTCAATTAACTTTTCAAGACCAAATAGAAATATTTCGTTTGTCAATAGCCCATTTTATTTAGTAAATGAATTTCAAAAGTGGGATGTAGAAAAAAATAAATTGAGAACAGCTGGGGTTAGCTCTTTTGGTTTTTCAGGTACGAATTGTCATATTATTCTACAAGAATTTTATCCTCCAGAAAATTTTTCCGATACTTCCAATACACATCAATCTGAACTGTGTTTTTGTTTTTCTAATCCAACAAAAAAGGGTTTAATTGCTTCATTAGAAGCGATGCACCAATTTTTACTCTTAAATAAAAAGATTAATTTAGAAAAATTATCGTTAAATCTTCTGTATAGAAAAAGTCATTATAAGAATCGGTTGGTAATCATTTCAGAAAATAAAGTGGAAAAACTTATTGAGAAAATTAATTTTACAATTAATAATTTGATTACTAAAAATAATGATACTTTTGTAAAAGATGAAAAAATATTTTTTTCATCAGAAGTTGGAAATAAAGCTTTAGAAGAAAAAGTGTTGACAGATTTGGAAAATTTGGCCACTAACTTTTGTAAAGGAATAGAGTTTGAAAAAAGAGTTCCAAAGTTAGTTCCAATGCCTTCAATCAAATTTTCAAAAAGCAAATTTTGGATTAACGCTGAAAACCGAAAAAATATGAGTCTTATTGTTGATGAAAAAGACAGTCGAAAAACATTAGAGATTATCATACAAAATACTTTTGGATATACAGATGTTAATTATCATGAAAGTTTTTTAGATCTAGGAATTGATTCTATTGGAATGATGAAAATCATTAATGAAGTTTCGGAATACTTTTCAAAACAATTAACTATAAGAGATCTTTATAAGTATAATACTATAAATGATTTGTCGGAATTTTTAAACTCTTCTAATGAATCCTCGAAGTTAAATAAAGAAAGTATTTCTAAGATTAAAAAAAATGATTTAAATGAATACACTACTTCCCCTCAACAAAAAAGAATGTACATTCACCAAATAAGATATCCAGAAAGTACTTCTAATAATGTGACTGCTCTATTGGAAATGAAAGGTAATATTCAGAGGGAAAATCTTGAAGAATCCATAAGAAAAGTTTTACAGAATCATGAAATTTTTCAAACAGTCTTCATGAATCACAATGAAATTAAGCAAAAAATTTTACCAAAAGAATCAGTAAATTTTTCATTAGAAACGATTTATTTAAATGATCCTAAGACAGAAGTTACCAATTTAATTGAGCCTTTTAAGTTATCTGATTTGCCTTTATTTCGAATTTATCACTTAGTATCTCTCTTGGATGCCTCAGAATATTTATTTATTGATTTTCATCATATTATTTGTGATGTTACTTCAATGGATATTTTTGTTAGAGAATTAATTACTGCTTATGAAGGAGGAGAAGCAGACCATTTCGATACAGAATATAAAGACTATGCACAGTGGTTAGATGATCATTTATTAAATACCATTTCTTATAAAAATCAAGAAAATTATTGGAAAAAAGAATTTATTGATTATACCTCCTATAATAATAGAGAAAGAATAAGTGAACGAGCTCAACAAAGGGAGGTAATCTTTGAAGCAGAGAAATATCAAAAAATCAAGACATTTTGCCAGAAAAATAGAATAACAGAGCATGTATTTTTGAATACAATGTTTGCATTGACATTGTATTATCTGGAGGAGCAAAATGATCAAATAATTGGGAATCCGGTCAGTGGTCGAGTGTCAACAAGTGTTGATCATGTTATTGGAATTTTTACCAATACTATTGCAACACGAACAAGAATTACAAAAGAAGATTCAATTATTCACTTACTGAAGCATACTCAAAGCAAAATGCTTGATTATTTAGATAATCAGGATTATCAGATTAATGATTTTGTTTCAGAAGTAAGAGATAAAAATGGAAACAGAATAAATATCAGTAAAATTTTTGCATTTCAAATTTTACCTAAAATAGTAATTTCTGATGGTGAGTTTATAGATATACCAATAAAAAATATAGAATCGAATTTTGAACTTGCTTTAGTTGCCTCACTAATTGGTGAGCAATTAGCTTTTAGAATAAAATATTTAATTTCTATTTATGATGAAAGCGATATTACTTTGCTATTTGAAACTTTTAATTCATTTATCGATGAGTCAATAAAAAATCCTGAATTGAAAATTTATCAATTGAAAGAAAAGTTTCAAAAGCAAGAAACAAAAGAAATAGCACAATTTGATTTTTAA","5.80","-17.88","126824","MSIKVAQAENLEEFWDLLKEGKETISSFPQQRSKDVHILENNNMKFEVGSYLEDIASFDPYFFNITPREAELMSPIQRLTLEKCLEALDDAGISKKTLNDSKTGIYLGHIGDLEGYKYKNWVNKFYNNDPMAIPGNLNSIIPSRISYVLNLKGPAVLIDTACSSSLVAISEACKSITNKECDMAIAGGIRISFCPETSSEKLGIESSNRQTRPFDSEADGTVLGEGVGIVVLKRLADAIKDEDHIYSVIKGVNVNQDGSSAGITAPNGKAQVDLLTELWKKYDINPQDIDYIEAHGTGTKLGDPIEIKALTQAVSKFTRRKQFCGIGSVKSNIGHLFEAAGVISVIKTALMIEKQHLVPSINFSRPNRNISFVNSPFYLVNEFQKWDVEKNKLRTAGVSSFGFSGTNCHIILQEFYPPENFSDTSNTHQSELCFCFSNPTKKGLIASLEAMHQFLLLNKKINLEKLSLNLLYRKSHYKNRLVIISENKVEKLIEKINFTINNLITKNNDTFVKDEKIFFSSEVGNKALEEKVLTDLENLATNFCKGIEFEKRVPKLVPMPSIKFSKSKFWINAENRKNMSLIVDEKDSRKTLEIIIQNTFGYTDVNYHESFLDLGIDSIGMMKIINEVSEYFSKQLTIRDLYKYNTINDLSEFLNSSNESSKLNKESISKIKKNDLNEYTTSPQQKRMYIHQIRYPESTSNNVTALLEMKGNIQRENLEESIRKVLQNHEIFQTVFMNHNEIKQKILPKESVNFSLETIYLNDPKTEVTNLIEPFKLSDLPLFRIYHLVSLLDASEYLFIDFHHIICDVTSMDIFVRELITAYEGGEADHFDTEYKDYAQWLDDHLLNTISYKNQENYWKKEFIDYTSYNNRERISERAQQREVIFEAEKYQKIKTFCQKNRITEHVFLNTMFALTLYYLEEQNDQIIGNPVSGRVSTSVDHVIGIFTNTIATRTRITKEDSIIHLLKHTQSKMLDYLDNQDYQINDFVSEVRDKNGNRINISKIFAFQILPKIVISDGEFIDIPIKNIESNFELALVASLIGEQLAFRIKYLISIYDESDITLLFETFNSFIDESIKNPELKIYQLKEKFQKQETKEIAQFDF","1281084","From Genbank:[gi:730336] This enzyme is potentially involved in some intermediate steps for the synthesis of a polyketide molecule which may be involved in secondary metabolism.","polyketide synthase","Cytoplasm","Matches in gapped BLAST to poliketide synthase:residues 131-242 are 100% similar to the previously published enzyme in S.mutans (gi|1661177|). Residues 1-571 are 37% similar to poliketide synthase in B.subtilis (gi|16078781|) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0349 (7e-22).","

InterPro
IPR000794
Domain

Beta-ketoacyl synthase
PTHR11712	$\"[1-509]T$ $\"[1086-1104]T$	Ketoacyl_synth

InterPro
IPR001242
Domain

Condensation domain
PF00668	$\"[675-958]T$	Condensation

InterPro
IPR006162
PTM

Phosphopantetheine attachment site
PS00012	$\"[613-628]?$	PHOSPHOPANTETHEINE

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[590-654]T$	PP-binding
PS50075	$\"[588-655]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[574-664]T$	ACP_like
SSF47336	$\"[581-657]T$	ACP_like

InterPro
IPR014030
Domain

Beta-ketoacyl synthase, N-terminal
PF00109	$\"[1-238]T$	ketoacyl-synt
PS00606	$\"[153-169]T$	B_KETOACYL_SYNTHASE

InterPro
IPR014031
Domain

Beta-ketoacyl synthase, C-terminal
PF02801	$\"[246-364]T$	Ketoacyl-synt_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.47.10	$\"[1-251]T$ $\"[252-418]T$	G3DSA:3.40.47.10
PTHR11712:SF4	$\"[1-509]T$ $\"[1086-1104]T$	PTHR11712:SF4

","BeTs to 10 clades of COG0304COG name: 3-oxoacyl-(acyl-carrier-protein) synthase IFunctional Class: IThe phylogenetic pattern of COG0304 is ----YqvCEBRhuj----inxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 873-990 are 27% similar to a (SYNTHETASE PHOSPHOPANTETHEINE PEPTIDE) protein domain (PD000924) which is seen in Q09164_EEEEE.Residues 209-292 are 34% similar to a (SYNTHASE POLYKETIDE CHAIN LENGTH) protein domain (PD063697) which is seen in Q9ZCH8_RICPR.Residues 274-311 are 55% similar to a (PHOSPHOPANTETHEINE TRANSFERASE SYNTHASE) protein domain (PD000237) which is seen in Q9RNB2_MICAE.Residues 274-313 are 57% similar to a (TRANSFERASE PHOSPHOPANTETHEINE SYNTHASE POLYKETIDE) protein domain (PD243863) which is seen in PKSK_BACSU.Residues 6-550 are 22% similar to a (C41A3.1) protein domain (PD067861) which is seen in Q18559_CAEEL.Residues 1-70 are 38% similar to a (PHOSPHOPANTETHEINE SYNTHASE TRANSFERASE) protein domain (PD028639) which is seen in Q9R9J1_BACSU.Residues 210-271 are 58% similar to a (SYNTHASE TRANSFERASE PHOSPHOPANTETHEINE) protein domain (PD000224) which is seen in Q9RNB2_MICAE.Residues 321-372 are 51% similar to a (SYNTHASE TRANSFERASE PHOSPHOPANTETHEINE) protein domain (PD000208) which is seen in Q9L8C8_BBBBB.Residues 145-197 are 60% similar to a (TRANSFERASE SYNTHASE PHOSPHOPANTETHEINE POLYKETIDE) protein domain (PD000145) which is seen in PPSB_MYCTU.Residues 12-70 are 43% similar to a (TRANSFERASE SYNTHASE PHOSPHOPANTETHEINE) protein domain (PD000325) which is seen in Q9L4W3_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 08:11:16 2002","Wed Apr 24 16:25:49 2002","Fri Oct 18 11:24:05 2002","Tue Mar 5 08:08:49 2002","","Tue Mar 5 08:08:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1226 is paralogously related (blast p-value < 1e-3) to SMu1223, SMu1224, SMu1222, SMu1225,all predicted bacitracin synthetases; and SMu1585, a predicted 3-oxoacyl-(acyl-carrier-protein) synthase.","Tue Mar 5 08:13:05 2002","","No significant hits to the NCBI PDB database.","SMU.1343c","","Residues 1 to 238 (E-value = 3.3e-63) place SMu1226 in the ketoacyl-synt family which is described as Beta-ketoacyl synthase, N-terminal domain (PF00109)Residues 246 to 416 (E-value = 2.3e-74) place SMu1226 in the Ketoacyl-synt_C family which is described as Beta-ketoacyl synthase, C-terminal domain (PF02801)Residues 590 to 654 (E-value = 1.6e-10) place SMu1226 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)Residues 675 to 958 (E-value = 3.6e-38) place SMu1226 in the Condensation family which is described as Condensation domain (PF00668)","Tue Mar 5 08:08:49 2002","24379755","","","Scotti,C., Piatti,M., Cuzzoni,A., Perani,P., Tognoni,A., Grandi,G.,Galizzi,A. and Albertini,A.M.A Bacillus subtilis large ORF coding for a polypeptide highlysimilar to polyketide synthasesGene 130 (1), 65-71 (1993)PubMed: 8344529","Tue Mar 5 08:09:38 2002","Tue Mar 5 08:09:38 2002","1","","12","SMU.1343c","" "SMu1227","1285645","1284428","1218","ATGGAGCAGATTATGAGATTAGTAGCATTATTTTCTGGTCAAGGAGTCAAAAAATTAGATTTTTCTTCTTTTTTTTTAAGTGAAAAGAACTTAAAAGAAATAATTGACAAAGGGAGTTCTGTTTTAGGAATAAATTTGAGAACAGAGATTATTTCCGAAGAACCAAAAACTATTTTGAATGATCCCTATCTTTCTCAAATTGCAGTTTTTTTATATAGTTTATTGGAGTTTAAAGATTTTGAAAGAAGAAAAGATATTGATCCAATTTATTTTGCAGGACAAAGTCTTGGTGAACTAACAGCTTTAGTATGTTCTAGAAAAGTTGATGTTGAAACAGGTTTTTATTTAGTAAAAAATCGGGCAAAATTTATGCAAGAGTGTATTGCTAAAGATGAAGGGAGTATGTATTCTCTCAAAAATGTGCCTATCAGTCGAATTGAAAGGTATATAAAAGAAATTAAATTAGAACAAAATATTTTTATTTCTAATATTAATTCGAGTAAACAAGTAATTGTTTCAGGAGAAAAACATTGTGTTGAGGAATTTATCTCTTATTTAGCATCTAAGAATGTTTATTATATGAAATTGAATACATTAGGAGCTTTTCATACAAAATTGATGGCTCCTGCTGCCAAAAAACTATTTAATCTATTGGGAGAGATTAATTTTGTACATAATGATAAAGTGTTATTCTCTAATGTTACAGGTTCGATATATGATAAAAGTAATTATAGAGAATTGCTTTCTCGCCAAATCTGCGAACCAGTTCAATGGCAAAAGATTATTGAAAATCTTCAATCTTATGGTCTCTCTAACTTTATTGAAATTGGAGGAAATCGGATTATAGCTAATTTATTAAAAGAATCAAGAATGAGTTTTAATAAATTAATTCCAGAAAATATTGATCCGAATGATCGGTTACAAGCATCGAGAGAAGTCATTTTATCATTTTGTCATTTTGGTATTAATCAAATGGTTATTAATAAAAATAGTAACCATTTATATGATCAAGAAATTATTAAAATTTACAAATATTTAGAACAAGCAAAAGAAAAGTTTTCAATTGAAGAGGAGATAGCTTTTTTAATTGAACTAGATGAAATTTATAATGAAGTCAAAAAAGCTTTAGTTTTAAAAGAAGTTAGTAATACCCAATTAGAACGATTTGATGAATGCTATTATACTTTTAAAAATGAAATTAATCACTATTTGAGGTAA","6.80","-0.80","47074","MEQIMRLVALFSGQGVKKLDFSSFFLSEKNLKEIIDKGSSVLGINLRTEIISEEPKTILNDPYLSQIAVFLYSLLEFKDFERRKDIDPIYFAGQSLGELTALVCSRKVDVETGFYLVKNRAKFMQECIAKDEGSMYSLKNVPISRIERYIKEIKLEQNIFISNINSSKQVIVSGEKHCVEEFISYLASKNVYYMKLNTLGAFHTKLMAPAAKKLFNLLGEINFVHNDKVLFSNVTGSIYDKSNYRELLSRQICEPVQWQKIIENLQSYGLSNFIEIGGNRIIANLLKESRMSFNKLIPENIDPNDRLQASREVILSFCHFGINQMVINKNSNHLYDQEIIKIYKYLEQAKEKFSIEEEIAFLIELDEIYNEVKKALVLKEVSNTQLERFDECYYTFKNEINHYLR","1284443","For other 'fab' genes see SMu1583 (fabZ); SMu1585 (fabF); SMu1586 (fabG); SMu1587 (fabD); SMu1588 (fabK); SMu1590 (fabH) and SMu1218 (fabK).","malonyl CoA-acyl carrier protein transacylase","Cytoplasm, Membrane","Matches in gapped BLAST to malonyl CoA-acyl carrier protein transacylases.Residues 10-288 are 32% similar to gi|15902424| from S.pneumoniae and 30% similar to gi|15672755| from L.lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0347 (7e-33).","

InterPro
IPR001227
Domain

Acyl transferase region
G3DSA:3.40.366.10	$\"[4-310]T$	Ac_transferase_reg

noIPR
unintegrated

unintegrated
PTHR10982	$\"[7-384]T$	PTHR10982
PTHR10982:SF4	$\"[7-384]T$	PTHR10982:SF4
SSF52151	$\"[6-308]T$	SSF52151
SSF55048	$\"[131-199]T$	SSF55048

","BeTs to 10 clades of COG0331COG name: (acyl-carrier-protein) S-malonyltransferaseFunctional Class: IThe phylogenetic pattern of COG0331 is ----YqvceBRhuj----inxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 5-133 are 30% similar to a (MDCG MALONYL-COAACP TRANSACYLASE) protein domain (PD301323) which is seen in Q9RGM2_ACICA.Residues 10-183 are 34% similar to a (PHOSPHOPANTETHEINE TRANSFERASE SYNTHASE) protein domain (PD000287) which is seen in Q9JSG5_CHLPN.Residues 196-283 are 36% similar to a (PHOSPHOPANTETHEINE TRANSFERASE SYNTHASE) protein domain (PD338968) which is seen in Q9FBC4_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 11:13:20 2002","Tue Mar 5 08:15:07 2002","Fri Oct 18 11:13:20 2002","Tue Mar 5 08:15:07 2002","","Tue Mar 5 08:15:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1227 is paralogously related (blast p-value < 1e-3) to SMu1587, and SMu1219, also predicted malonyl-CoA acyl-carrier transacetylase proteins.","Tue Mar 5 08:17:56 2002","Tue Mar 5 08:15:07 2002","pdb|1MLA| Mol_id: 1; Molecule: Malonyl-Coenzyme A Acyl Carrie... 106 5e-024","SMU.1344c","","Residues 8 to 324 (E-value = 6.9e-05) place SMu1227 in the Acyl_transf_1 family which is described as Acyl transferase domain (PF00698)","Tue Mar 5 08:15:07 2002","24379756","","","Morbidoni HR, de Mendoza D, Cronan JE Jr. Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes. J Bacteriol. 1996 Aug;178(16):4794-800. PMID: 8759840","","Tue Mar 5 08:17:56 2002","1","","12","SMU.1344c","" "SMu1228","1287561","1285660","1902","ATGATGTTAATACAATGCCTTAATGAAACTATTTTGAGAGAACCAGAAAAAGGGATTTATTATTTAGAAAATGGTAAATATAAGTTTGAAACCTATGAACATTTACGAACTAATGCTCTTAACTATTTAGGTGCACTGCAAGAATTAGGAATTGAAGAAGGACAGGAAGTTGTTTTTCAGACTACACATAATAATAAATTCTTATATTTGTTGTGGGCCTGTTTCTTAGGGGGATATATTGCCATACCAACTGGGTTTGATTCCATAGAATATATTCAAGGAACAAATAAAGTTATTAATAAGTTAAAAAAGCCAGTCCTTATAACAGAGTTAGAGAAGCAGTGTGAAAATATAGTATTGAAAGATAAATTTTCTTTATCTTCACTTGATACTAAAAAAATAACAGGTAGGGTAACCCAAAATAATTCAAAAGATAGAATTGTTATGGTTCAATTTTCTTCAGGTTCAACTGGGGAACCAAAAGGGGTTATTTATACTGATAATACATTATCTACTAATATGTTTTCTATTTTAAAATCAACCGAATGGAAAACTGAAGAGAGGATTCTAACTTGGTTAACATTAACTCATAATATGGGACTTGCTTCAGGACATTTGGCTCCTTTAATAAAGGGAATGAATCAATATTTAATGCCGACACGTGAATTTATTGTACATCCAATAAATTGGCTATATCAAATTGATAAATACAAAATTAATATTGTTTCTTGTCCTAATTTTGCCTCAAAATTATTGATAAAAACATTAAATACAACCAAAATTAATGACGTAGATTTATCTAGTATTAATATGATTATTAATGGTTCAGAACCAATAGATTATGGATTATGTGAGGAACTTACTAAGCATTTGTCTAAATATAAGTTGAGGGAAAATTGTATTTACCCAGTGTATGGATTAGCAGAAAATACAGTAGCAGCTTGTTTGCCTAAAGCTCAATCACCATTAAAAACAATAACAATAGGACATGAAGGGGTGACAGTCGGGGAACCTGCTATTATAAGAAAAGAGTCAGAAGGTTATAGAGTTGTTTCTGTAGGAAAAGCCATATCGGAAACAGACATCCGAATTGTTGATAATGATAATAAAATTCTTCCCGAAGGATATTATGGAAATATTGAGTTAAATGGATTGAGTGTTACACCAGGTTATTACAATAATGAGAAAGAGTCAGAAAAAATATTTAGTGATGATGGGTGGTTAAAAACAGGAGATCAAGGTTTAATTTTTGATAATGAATTATATATATTTGGTAGGGAAAAAGAAATTATCATTATATATGGACATAATTATTATCCAAATGATATAGAACAAACTATTGTTCAAAAAATTCCAGAGTTATCAGGAAGAGTTGTAATTATTGGTGTCAACAATTCTAATTCAAATGAAGAAGTTTTTTGTTTTATTGAAAAAAGGCAAAGTGAAAATATTTTTGATTTATACAAATATGGTAAAAAAATAAAGAAAATTGTAAATAAATTTAAGAAATTACAAATTAATGAGGTATATCCAATTTCTGTAATTCCTAAGACACGAAGTCAGAAATTGAAAAGAGTTGAGTTAAGACAAAGAATACAAGGTGGCGAGTTCCTTGAATATAATGAGTTGTTCGAATTATTAAATCTTTTCGAAGAACAAACGATAGAAAATACAATAGAAAATTTTATTATTTTATTTACAGAATACCAACTTGGCCTGAAAAATATTGAACTAAATACAAATTTTTTTGAACTCGGGTTCTCCTCAATTACTATTATGAAATTTGTTGAAATGATTAATCTTGCATTTGATACTGAAATTAGTGAAACTGATATTTTCTTTTATGAAACTCCTAAATTGTTAGCAGAGTATATTGAAGAGCAAATAAGACTATTGAGTTAA","5.30","-12.37","72792","MMLIQCLNETILREPEKGIYYLENGKYKFETYEHLRTNALNYLGALQELGIEEGQEVVFQTTHNNKFLYLLWACFLGGYIAIPTGFDSIEYIQGTNKVINKLKKPVLITELEKQCENIVLKDKFSLSSLDTKKITGRVTQNNSKDRIVMVQFSSGSTGEPKGVIYTDNTLSTNMFSILKSTEWKTEERILTWLTLTHNMGLASGHLAPLIKGMNQYLMPTREFIVHPINWLYQIDKYKINIVSCPNFASKLLIKTLNTTKINDVDLSSINMIINGSEPIDYGLCEELTKHLSKYKLRENCIYPVYGLAENTVAACLPKAQSPLKTITIGHEGVTVGEPAIIRKESEGYRVVSVGKAISETDIRIVDNDNKILPEGYYGNIELNGLSVTPGYYNNEKESEKIFSDDGWLKTGDQGLIFDNELYIFGREKEIIIIYGHNYYPNDIEQTIVQKIPELSGRVVIIGVNNSNSNEEVFCFIEKRQSENIFDLYKYGKKIKKIVNKFKKLQINEVYPISVIPKTRSQKLKRVELRQRIQGGEFLEYNELFELLNLFEEQTIENTIENFIILFTEYQLGLKNIELNTNFFELGFSSITIMKFVEMINLAFDTEISETDIFFYETPKLLAEYIEEQIRLLS","1285675","","peptide synthetase similar to mycA","Cytoplasm, Membrane, Extracellular","This sequence corresponds to the previously published GI:2952529, a predicted D-alanine-D-alanyl carrier protein ligase.Significant hits in gapped BLAST to different types of synthetases .Residues 16-627 are 31% similar to gi|16040970| and gi|11356524| as seen in B.subtilis. Residues 9-628 are 26% similar to gi|6007550| as seen in Microcystis aeruginosa. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1790 (2e-15).","

InterPro
IPR000873
Domain

AMP-dependent synthetase and ligase
PR00154	$\"[145-156]T$ $\"[157-165]T$	AMPBINDING
PF00501	$\"[142-459]T$	AMP-binding
PS00455	$\"[150-161]T$	AMP_BINDING

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[561-625]T$	PP-binding
PS50075	$\"[551-626]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[557-628]T$	ACP_like
SSF47336	$\"[552-627]T$	ACP_like

noIPR
unintegrated

unintegrated
G3DSA:2.30.38.10	$\"[352-424]T$	G3DSA:2.30.38.10
G3DSA:3.30.300.30	$\"[428-542]T$	G3DSA:3.30.300.30
G3DSA:3.40.50.980	$\"[143-328]T$	G3DSA:3.40.50.980
PTHR22754	$\"[143-536]T$	PTHR22754
PTHR22754:SF4	$\"[143-536]T$	PTHR22754:SF4
SSF56801	$\"[2-535]T$	SSF56801

","BeTs to 8 clades of COG0318COG name: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases IIFunctional Class: IThe phylogenetic pattern of COG0318 is A-t-Y---EBRh------inxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 9-113 are 33% similar to a (PHOSPHOPANTETHEINE TRANSFERASE POLYKETIDE) protein domain (PD332570) which is seen in Q9FDT8_MICAE.Residues 198-279 are 46% similar to a (COMPLETE PROTEOME LIGASE SYNTHETASE) protein domain (PD003675) which is seen in Q9R9J1_BACSU.Residues 305-444 are 29% similar to a (PROTEOME COMPLETE CY10H4.35 TRANSMEMBRANE) protein domain (PD207479) which is seen in P71605_MYCTU.Residues 186-279 are 35% similar to a (LIGASE SYNTHETASE COMPLETE PROTEOME ACETYL-COENZYME) protein domain (PD000070) which is seen in Q9I157_PSEAE.Residues 362-416 are 43% similar to a (LIGASE PROTEOME COMPLETE METABOLISM) protein domain (PD001741) which is seen in PKSJ_BACSU.Residues 145-197 are 41% similar to a (LIGASE SYNTHETASE PROTEOME COMPLETE ACYL-COA SYNTHASE) protein domain (PD246510) which is seen in Q9R9J1_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 08:56:24 2002","Tue Mar 5 08:56:24 2002","Fri Oct 18 10:33:31 2002","Tue Mar 5 08:55:34 2002","","Tue Mar 5 08:55:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1228 is paralogously related (blast p-value < 1e-3) to SMu1225 and SMu1222,predicted bacitracin synthetases; SMu1223 and SMu1224, predicted gramicidin S synthetases; SMu1541, a predicted D-alanine-D-alanyl carrier protein ligase; and SMu1226, a predicted poliketide synthase.","Tue Mar 5 08:56:24 2002","Tue Mar 5 08:55:34 2002","pdb|1BA3| Firefly Luciferase In Complex With Bromoform >gi|20... 72 2e-013","SMU.1345c","","Residues 31 to 459 (E-value = 6.3e-46) place SMu1228 in the AMP-binding family which is described as AMP-binding enzyme (PF00501)Residues 561 to 625 (E-value = 2.4e-06) place SMu1228 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)","Tue Mar 5 08:55:34 2002","24379757","","","Tsuge,K., Akiyama,T. and Shoda,M.Cloning, sequencing, and characterization of the iturin a operonJ. Bacteriol. 183 (21), 6265-6273 (2001)PubMed: 11591669Duitman,E.H., Hamoen,L.W., Rembold,M., Venema,G., Seitz,H.,Saenger,W., Bernhard,F., Reinhardt,R., Schmidt,M., Ullrich,C.,Stein,T., Leenders,F. and Vater,J.The mycosubtilin synthetase of Bacillus subtilis ATCC6633: Amultifunctional hybrid between a peptide synthetase, an aminotransferase, and a fatty acid synthaseProc. Natl. Acad. Sci. U.S.A. 96 (23), 13294-13299 (1999)PUBMED 10557314","","Tue Mar 5 09:05:59 2002","1","","12","SMU.1345c","" "SMu1229","1288292","1287573","720","TTGAATAAAACAAAAAAAGTTGTCCTATTTTGTATTCCTCATGCTGGAGGTAATAGTAGTATCTTTAACAAATGGAGCGGGTACATGCCCGATAATATTATTTTTAAACCAATTGAATTAAGTGGTAGAGGAAAGCGTTTGAACGAAAAATTAGATGCTAGTTTTGAAGATATGATTGATGATGTTTTTAATTCTATCAAAAAAATAATGGTTAATTTTGATATGGATTATTATATTTTTGGTCATAGTATGGGAGCTTGGATAGTGTTAGAATTACTTTATTATTTTAAAGAATACCATTTACCTTATCCAAAAGGTGTAATATTTTCTGGGAATATCCCACCTTGTTTTTATCATAAGTCTGACCCACCACTTCATTTGTTACCAGATAAAATATTTCTAGAAGAAGTCTCAAAATTGGGAGGGATACCTGGAAAAATAATAAAAGAAAAACAATTTGTAGAATATTTTGTTCCTATTATAAAAAATGATTTTAAATTGATAGAGAACTATTATTTTCAACAGAAGCAGGAAAAGTTTCCTGTAAAAAGTCTGATTTGTAGTGGTAAAGATGATAAATTTCGGGTAAAGGATTTGGTACAATGGGAAAATTACTTTATTGATAAGTGCTCAATATCTTTATTTAAAGGTGGCCATTTTTACATCGATGACAATATTGCTAGTCTTTGTAATCAAATAAAAGATTTTATTTATATGTAG","8.10","3.21","27970","MNKTKKVVLFCIPHAGGNSSIFNKWSGYMPDNIIFKPIELSGRGKRLNEKLDASFEDMIDDVFNSIKKIMVNFDMDYYIFGHSMGAWIVLELLYYFKEYHLPYPKGVIFSGNIPPCFYHKSDPPLHLLPDKIFLEEVSKLGGIPGKIIKEKQFVEYFVPIIKNDFKLIENYYFQQKQEKFPVKSLICSGKDDKFRVKDLVQWENYFIDKCSISLFKGGHFYIDDNIASLCNQIKDFIYM","1287588","For other 'bac' genes see SMu0221 (bacA); SMu1223 (bacA2); SMu1222 (bacD) and SMu1225 (bacA). ","thioesterase II-like protein","Cytoplasm, Extracellular","Several matches in gapped BLAST to thioesterase II-like protein: residues 9-229 are 34% similar to the protein in Bacillus licheniformis (gi|7474360|) and are 29% similar to the protein from Bacillus halodurans (gi|15614401|).SMu1229 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001031
Domain

Thioesterase
PF00975	$\"[7-237]T$	Thioesterase

InterPro
IPR012223
Family

Thioesterase type II, NRPS/PKS/S-FAS
PIRSF000881	$\"[7-238]T$	Type II thioesterase, NRPS/PKS/S-FAS types
PTHR11487	$\"[2-239]T$	THIOESTERASE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[7-239]T$	no description
tmhmm	$\"[78-96]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 141-229 are 29% similar to a (THIOESTERASE BIOSYNTHESIS HYDROLASE) protein domain (PD003001) which is seen in Q9R2X9_BACLI.Residues 9-48 are 52% similar to a (THIOESTERASE BIOSYNTHESIS HYDROLASE) protein domain (PD090754) which is seen in Q9R2X9_BACLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 22 08:51:44 2002","Tue Mar 5 09:13:16 2002","Fri Oct 18 09:27:03 2002","Tue Mar 5 09:13:16 2002","","Tue Mar 5 09:13:16 2002","yes","Tue Oct 22 08:51:44 2002","SMu1229 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 09:13:40 2002","","No significant hits to the NCBI PDB database.","SMU.1346c","","Residues 7 to 237 (E-value = 7.5e-18) place SMu1229 in the Thioesterase family which is described as Thioesterase domain (PF00975)","Tue Mar 5 09:13:16 2002","","","","Konz,D., Klens,A., Schorgendorfer,K. and Marahiel,M.A.The bacitracin biosynthesis operon of Bacillus licheniformis ATCC10716: molecular characterization of three multi-modular peptidesynthetasesChem. Biol. 4 (12), 927-937 (1997)PubMed: 9427658","","Tue Mar 5 09:13:16 2002","1","","12","SMU.1346c","" "SMu1230","1290627","1288285","2343","ATGAAAATTTTATTAAAAAAATTATTTAGAGATATTCGTACCAATATAGCACAATTTATAACAATTATTTTAATTGTTTCTATTGGTTCCTTTCTTTTTGTTGGCTTGTCTAGTGTTGCCAGTAGCTTAAGAGATTATACAAAAAACTACTATCATGACTATCACCTGAGCGATGCAACAGTAAATTTTATTTCGCTTACTTCAAAAAAGATAGATGCTATTAAAGATAAATATACTAATATACAAGAGGCAGAGGGACGTGTTAATTTTGAAGGAAAACAAACTTTCAAAAATTATAGCTCTGCTTTAACAATTTCTAGCTTTTCTCCTACTTCTAAGCTAAATCGTTCTTATATTGTGCAGGGAAGAAAAAAACTCAATAACAACGAAATCTTGTTAGATAGTGATTATATTAAGGCGCATCATTATAAGATGAATGATTCTATACAAATTCAAATCAATAGTAAGAAGTTCACTTTTAAAATCGCAGGAATTATTGAGAATCCTGAGTTTGTTATGAAAGTATCAGGAAATAATTTAACACCTGAGCCTCAAAAATTCGGCATAGGTTATATCACAGAACAGAAAGCTTTCGATATTTCAAAAAAAAATCATTCTTATAATCAACTTCTTTTAAAGATTAAGGGTAATAATAGTAAAAAGGTTCTTCAAAAACTTTCTGAAGATTATGATACAACTTATATTTCTGGTCTTGTTACAACTGAATCAAGTAACTACACTAATTTAAAAAGTTTAATCACAACCGATGAAAGTCTTAGCAGGGTTATTCCTATCTTATTCTTTATTGTTGCTGCGGTCATTACTTTTATTTCAATGACACGGCTCATACAACAAAACAGAGTACAGACAGGAATCATGCGCTCCTTAGGTAAAAGAATTAGATACATAAGAAGTTATTACTTATTCTATACTTTATTGACAAGTTCTATTGGGACATTTATTGGAAGTGTGCTAGCTTACTTTGCTTTTACTGATATTGGTGAAGCTCAAGTATCTTCATTGTATGCTTTACCAAATTATCATGTGAAGATTGAGTTACAATCTTTGATTCCTTCTTTTTGCCTTGTTTTATTATTTGGTTTATTAGCTATTTATTTTTCAACGCGAAAAGTTTTAAAAGAGAGACCAGCAAATTTGATTAGACAGGAGCCTCCTAAAAATATTAAAGGTATTTTATTAGAAAGGATTCCTTTCTTATGGCGGTATTTATCTTATGGAAGTAAATATGTTATTCGGAATATTTTCTTAAATAAAATACGTTTTTGCCTTAATTTACTAGGTGTTGCTTTATCTTTTTTGATGATTATATTAGCTTTTGGTTATTATAACGCTATGACTACTGTAGTTAATACGGAAATTAATGATGTCAATACTTATAATATTAGTATTATTTCTCCTAAAATTAACTCTATACAAGATAAATTATCAAATAATCCACATCTAAAGTTTGAAAAGTTAGATATTCAAAAGTTAGAACTTGGACAAGGAAATAATAGTATTGCAACGACTTTATATGCTAGTAGTCAAAAAGAGCATTTTATGAAAGTTTATAAGAAAAACGGTCAAGAATTGTCTCACTATTCAAATGGCATTGTCATACCAAAGGTTTATGCTAATAAGCTTCATTTAAAAATTGGGGATAAAGTAAGATTAGCCTTTTCAAATACTCAACAATCTCCCATAAAAGTTAGAGTAACAGCCATATCAACCCAATATTCTTCTAAATTTATTGTTGCTGACGCTGACTATTTGAAAGAACAAGGCGTTACCCTTCACCCCTCAATGCTATTAATCCAAAAAGGAAAAAATAGTAATGAAAAAACATCCCAATTAATTCAATCGGCCAAAGTTATTGATAAGGATTTAACTTATACAACTAAAAAGGATGTTCGATCAAATATGAATGCTATTTTATCAACGACATTTCCAATGGTTGTTCTATTTCTTATTTGTGCCATGTCATTAACAGTAGCGACTATTTATAATATTTCATCTATTAATATTTTTGATCGAACTAGAGATATTGCCACACTCAAAGTGTTAGGCTACTCTAAAAATAAAGTGAATAACCTTATTTTTAAGGAAAATATAATTATTTCTTGTGTAGCTATGGGCTTTGCTTTACCTGTCGGTCATTCGCTCTTTATCCTTTTTATTAACGCTATGACGACAGAACTGCAGGCTATGCCGAACGAATTACCATATTGGTGTTTTGCTTTAGCTATTGTCTGTGTTTTAGGAATCACCATTTTATCAAATTTACTTTTGCATCGAAAGGTTAAAGCCATTGATATGATTGAGGGGTTAAAGAGTATTGAATAA","10.50","41.87","88420","MKILLKKLFRDIRTNIAQFITIILIVSIGSFLFVGLSSVASSLRDYTKNYYHDYHLSDATVNFISLTSKKIDAIKDKYTNIQEAEGRVNFEGKQTFKNYSSALTISSFSPTSKLNRSYIVQGRKKLNNNEILLDSDYIKAHHYKMNDSIQIQINSKKFTFKIAGIIENPEFVMKVSGNNLTPEPQKFGIGYITEQKAFDISKKNHSYNQLLLKIKGNNSKKVLQKLSEDYDTTYISGLVTTESSNYTNLKSLITTDESLSRVIPILFFIVAAVITFISMTRLIQQNRVQTGIMRSLGKRIRYIRSYYLFYTLLTSSIGTFIGSVLAYFAFTDIGEAQVSSLYALPNYHVKIELQSLIPSFCLVLLFGLLAIYFSTRKVLKERPANLIRQEPPKNIKGILLERIPFLWRYLSYGSKYVIRNIFLNKIRFCLNLLGVALSFLMIILAFGYYNAMTTVVNTEINDVNTYNISIISPKINSIQDKLSNNPHLKFEKLDIQKLELGQGNNSIATTLYASSQKEHFMKVYKKNGQELSHYSNGIVIPKVYANKLHLKIGDKVRLAFSNTQQSPIKVRVTAISTQYSSKFIVADADYLKEQGVTLHPSMLLIQKGKNSNEKTSQLIQSAKVIDKDLTYTTKKDVRSNMNAILSTTFPMVVLFLICAMSLTVATIYNISSINIFDRTRDIATLKVLGYSKNKVNNLIFKENIIISCVAMGFALPVGHSLFILFINAMTTELQAMPNELPYWCFALAIVCVLGITILSNLLLHRKVKAIDMIEGLKSIE","1288300","For other components see SMu1231 (NBD1).","ABC transporter permease protein","Membrane, Cytoplasm","Matches weakly in gapped BLAST to ABC transporters and to membrane protein:residues 1-779 are 22% similar to PsaB in S.mutans (gi|15625441|). Residues 36-778 are 24% similar to membrane protein in Clostridium acetobutylicum (gi|15894110|).Residues 203-779 are 25% similar to ABC transporter permease protein from Lactococcus lactis subsp. lactis (gi|15673086|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1003 (3e-46).","

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[207-383]T$ $\"[600-772]T$	FtsX

noIPR
unintegrated

unintegrated
SSF89447	$\"[519-593]T$	SSF89447

","BeTs to 13 clades of COG0577COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0577 is AMt--QVcEBRHuj--OLinxNumber of proteins in this genome belonging to this COG is 7","***** IPB003838 (DUF214) with a combined E-value of 2.2e-09. IPB003838A 667-714 IPB003838A 275-322","Residues 3-226 are 22% similar to a (PROTEOME COMPLETE) protein domain (PD213592) which is seen in O28455_ARCFU.Residues 145-447 are 22% similar to a (TRANSMEMBRANE PROTEOME MG064 MG468) protein domain (PD018584) which is seen in Q9PQH4_UREPA.Residues 2-251 are 23% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD401701) which is seen in Q9CGJ2_LACLA.Residues 254-732 are 25% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD147912) which is seen in Q9CGJ2_LACLA.","","Thu Nov 29 18:44:30 2001","Thu Nov 29 18:44:30 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:21:31 2002","Tue Mar 5 09:21:33 2002","Tue Oct 22 07:55:56 2002","Tue Mar 5 09:21:33 2002","Tue Mar 5 09:21:33 2002","Tue Mar 5 09:21:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1230 is paralogously related (blast p-value < 1e-3) to SMu1245, SMu1752, SMu1067, SMu1000, all predicted secretion ABC transport permease and SMu0787, a conserved hypothetical.","Tue Mar 5 09:24:28 2002","","No significant hits to the NCBI PDB database.","SMU.1347c","Thu Nov 29 18:44:30 2001","Residues 207 to 383 (E-value = 1.7e-23) place SMu1230 in the FtsX family which is described as Predicted permease (PF02687)Residues 600 to 772 (E-value = 1.3e-17) place SMu1230 in the FtsX family which is described as Predicted permease (PF02687)","Tue Mar 5 09:21:33 2002","24379759","","","","Mon Oct 28 11:21:31 2002","","1","","12","SMU.1347c","" "SMu1231","1291333","1290632","702","ATGAACATTATTGAATTTAAAAGTGTATCGAAAAGATACAAAGTAGGAAATCAGGAAATTGAAGCAGTAAAGCATGTTTCATTCAACATTGAATCCGGAGAATTTGTAGTTGTTTTAGGAGCCAGTGGCGCTGGAAAAAGTACTATTCTTAATTTATTGGGGGGAATGGATACAGTATCTGAAGGTCAAATACTTGTTGAAGGACAGGATATTGTTAACTTCAGTGAAAAGGAATTAACAAAATACCGTGCTGAAAAAATTGGTTTTGTTTTTCAATTTTATAACCTTATATCAAATTTGAATACCCTAGAAAATGTGGAATTTGCCATAGAGGTATCCCAAAAATCTCTGAATCCAAAGGATATTCTAAAAAGAGTAGGATTGTCTGAACGATTAAAGAACTTTCCTTCACAACTTTCAGGAGGTGAACAACAAAGGGTATCAATAGCACGAGCCATTGCTAAAAATCCTCTGTTATTACTCTGCGATGAACCTACAGGAGCTTTAGATTATGAAACTGGGAAGGAAGTCCTTCAATTGATTAAGGAATTAAACGAAAGTACCAAAAAGAGCGTTGTTTTAATCACTCATAATAGTGCTATTTCAAAAATTGCCGATAAAGTCATTCATGTTCGAAGCGGACAAATCGAGAAAATTGAATATAATTCAGATAAAATTCCAGTTTCAGAGTTAGAGTGGTAA","5.90","-2.31","25868","MNIIEFKSVSKRYKVGNQEIEAVKHVSFNIESGEFVVVLGASGAGKSTILNLLGGMDTVSEGQILVEGQDIVNFSEKELTKYRAEKIGFVFQFYNLISNLNTLENVEFAIEVSQKSLNPKDILKRVGLSERLKNFPSQLSGGEQQRVSIARAIAKNPLLLLCDEPTGALDYETGKEVLQLIKELNESTKKSVVLITHNSAISKIADKVIHVRSGQIEKIEYNSDKIPVSELEW","1290647","For other components see SMu1230 (MSD1). For other 'psa' genes see SMu1001 (psaA); SMu1067 (psaB);SMu1068 (psaA); SMu1069 (psaR); SMu1171 (psaR); SMu1752 (psaB) ; SMu1750 (psaR) and SMu1751 (psaA). ","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","This sequence corresponds to the previously published gi|15625442| , gi|4098078|, and gi|9802355|, predicted ABC transporters in GenBank. Significant hits in gapped BLAST to ABC transporter. Residues 2-233 are 59% similar to gi|15894109| as seen in Clostridium acetobutylicum. Residues 1-233 are 54% similar to gi|16800255| as seen in Listeria innocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1004 (7e-73).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[138-181]T$	ABC_transporter
PF00005	$\"[33-214]T$	ABC_tran
PS00211	$\"[139-153]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-231]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[32-215]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-216]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-220]T$	PTHR19222
PTHR19222:SF32	$\"[4-220]T$	PTHR19222:SF32
SSF52540	$\"[1-216]T$	SSF52540

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[5-69]T$	Homeodomain_like

","BeTs to 3 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 18:07:05 2002","Mon Oct 28 18:07:05 2002","Mon Oct 28 18:07:05 2002","Tue Mar 5 09:38:06 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1232 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 28 18:07:05 2002","","No significant hits to the NCBI PDB database.","SMU.1349","","No significant hits to the Pfam 11.0 database","Tue Mar 5 09:38:06 2002","24379761","","","","","","1","","12","SMU.1349","" "SMu1233","1292444","1292812","369","ATGATGCCAAGAGAAGTATTTGATAAAGCATTCAAAATAGCTGCAGTTAAACTCATTCTAGAGGAAGGACAGTCTGTAAAAATGGTTAGTTCAACTTTAGAGTTCATCCAAAAATCGTTTATATCGCTGGATTCAAGAAGACGAAAAATATGGAGAAAGAGCGTTCTCAGGACAGGGGAGCGCTCTTCGTCATGCCCAAAGCGTAAGCCATCTTCAAGACAGATAGAGAATGAAGCGTTAAAGGAAATCATTAAGACTATTTTCTATGAACATAAAGAACGCTATCGACGAGGAATAAGGGTCAATCGCAAACGTATTGCTAGACTATTTCATGAACTTTGTCTCTATGCTAAAGGAAGCCTGCTATAA","11.30","17.38","14457","MMPREVFDKAFKIAAVKLILEEGQSVKMVSSTLEFIQKSFISLDSRRRKIWRKSVLRTGERSSSCPKRKPSSRQIENEALKEIIKTIFYEHKERYRRGIRVNRKRIARLFHELCLYAKGSLL","1292821","","transposase fragment","Cytoplasm, Periplasm","Matches in gapped BLAST to transposase:residues 74-120 are 45% similar to gi15672352, gi15672035,and gi2467221 as seen in L. lactis.SMu1233 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PD688335	$\"[79-109]T$	PD688335

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[30-107]T$	rve
PS50994	$\"[23-107]T$	INTEGRASE

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[25-107]T$	RNaseH_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.10	$\"[25-107]T$	G3DSA:3.30.420.10

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 68-107 are 62% similar to a (TRANSPOSASE PLASMID OF ELEMENT) protein domain (PD001459) which is seen in Q9CB05_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 09:16:48 2002","Tue Mar 5 09:47:14 2002","Fri Oct 18 09:16:48 2002","Tue Mar 5 09:47:14 2002","","Tue Mar 5 09:47:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1234 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Oct 18 09:16:48 2002","","No significant hits to the NCBI PDB database.","SMU.1352","","No significant hits to the Pfam 11.0 database","Tue Mar 5 09:47:14 2002","24379763","","","","","","1","","12","SMU.1352","" "SMu1235","1293138","1293293","156","ATGACGCAGAAAAAATGTCAGTCTAGTATGAGTCGAAAAGGTAATCCATATGATAATGCACTCATGGCATCCTTTTACAAGACCTTAAAAAGAGAGCTTGTCAACGATGCGCATTTTGCATCCATTGAACAAGCCCAACTTGAAATCTTTAAATAG","10.00","3.17","5881","MTQKKCQSSMSRKGNPYDNALMASFYKTLKRELVNDAHFASIEQAQLEIFK","1293302","","transposase","Periplasm, Cytoplasm, Extracellular","This sequence was previously published in GenBank as gi|3873218|, a predicted transposase. Residues 7-49 are 46% similar to transposase from S.mutans. Furthermore, residues 1-51 are 70% similar to gi|15672035|,gi|15672352|, and gi|2467221| a predicted transposase from Lactococcus lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0639 (3e-07).","

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[1-51]T$	RNaseH_fold

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 7-51 are 77% similar to a (TRANSPOSASE PLASMID COMPLETE OF) protein domain (PD000334) which is seen in Q9CB04_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 10:00:16 2002","Tue Mar 5 10:00:16 2002","Fri Oct 18 09:16:28 2002","Tue Mar 5 09:59:58 2002","","Tue Mar 5 09:59:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1235 is paralogously related (blast p-value < 1e-3) to SMu1719, SMu1283, SMu1258, SMu0695, SMu0514, and SMu0395, all transposase-related.","Thu Mar 21 15:19:25 2002","","No significant hits to the NCBI PDB database.","SMU.1353","","No significant hits to the Pfam 11.0 database","Tue Mar 5 09:59:58 2002","24379764","","","","","","1","","12","SMU.1353","" "SMu1236","1293939","1293679","261","GTGACGGAAAACAAGCTAAATCGTGAGTTTCAAGCAGAAAAGCCACTGGAGAAGCTAGTCACAGACATTACCTATCTCTACTTTGGGAGCTGTAAACGCTACCTATCCTCCATCATGGATCTCTATAATCATAATCGTGAAATTGTAGCTTACACTATTTCGGATTGCCAAGATATTGACTTTGTACTGGATACGCTCAATCAATTGGAATTGCCTAGGGGAGCATTTTATACAGTGATCAGGGCTCTGTTTACACCTTAA","4.80","-2.87","10069","MTENKLNREFQAEKPLEKLVTDITYLYFGSCKRYLSSIMDLYNHNREIVAYTISDCQDIDFVLDTLNQLELPRGAFYTVIRALFTP","1293694","","transposase","Cytoplasm","Matches in gapped BLAST to transposase:residues 2-75 are 71% similar to the transposase in Listeria monocytogenes (gi|16802870|). Residues 10-74 are 58% similar to the protein from S.aureus (gi|11277971|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1244 (5e-08).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 10:07:09 2002","Tue Mar 5 10:04:38 2002","Fri Oct 18 09:15:47 2002","Tue Mar 5 10:04:38 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1236 is paralogously related (blast p-value < 1e-3) to SMu1250, SMu0798, SMu1719, SMu1283, SMu1258, SMu0695, SMu0514, and SMu0395, all predicted transposases.","Tue Mar 5 10:09:02 2002","","No significant hits to the NCBI PDB database.","SMU.1354c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 10:04:38 2002","24379765","","","","","","1","","12","SMU.1354c","" "SMu1237","1294247","1293954","294","GTGGAAGACTACAAGAATGTCTACCCAGTGTCTATCATTCTAGACTGTTTCGGCGTCAAACGCTCAACTTTCTACCGTTGGAAAGCAAAAGGCGAAAAACCTGAGAAGAGAGACAAGATTGTAGAAAAAATCGAGCAACTCTGTATGAAAAATCATTTTATCTACGGTTATCGTACTATTACACGACTACTTAAGAAAATTCATGGACTAATCGTTAATCGCAAGAAAGTCTATCGAATTATGAAGGAAAAAGGCTGGCTCTGTCGTGCACGTCCTAAGAAAGTACAAATCTAG","10.90","17.32","11743","MEDYKNVYPVSIILDCFGVKRSTFYRWKAKGEKPEKRDKIVEKIEQLCMKNHFIYGYRTITRLLKKIHGLIVNRKKVYRIMKEKGWLCRARPKKVQI","1293969","","transposase","Cytoplasm","Matches in gapped BLAST to transposase: residues 1-94 are 39% similar to gi|15923057| and gi|15925770| from S.aureus.Residues 17-94 are 37% similar to gi|2098612| from Marinococcus halophilus The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1068 (1e-07).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-66 are 46% similar to a (ELEMENT ORFB B. PLASMID) protein domain (PD413066) which is seen in Q44622_BACAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 10:14:47 2002","Tue Mar 5 10:14:17 2002","Fri Oct 18 09:15:13 2002","Tue Mar 5 10:14:17 2002","","Tue Mar 5 10:14:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1237 is paralogously related (blast p-value < 1e-3) to SMu1719, SMu1283, SMu1258, SMu0695, SMu0514, and SMu0395, all predicted transposases.","Tue Mar 5 10:14:47 2002","","No significant hits to the NCBI PDB database.","SMU.1355c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 10:14:17 2002","24379766","","","","","","1","","12","SMU.1355c","" "SMu1238","1294552","1294262","291","ATGGTCAAAAAAGCCTATTCAGTGGAAACTAAGTTAGCCTGTATCGAAATGAAAAAGGCGGGTAAGTCTAACAAGGTCATTAAGGAGACTTTGAGAATTAAGAATGATAGTCAAATCTACACTTGGATGAGATGGTATGAAAACGACGAATTGCACCGTTTTCATCAAGCTGTAGGCAAACAATATACCTACGGTAAAGGTATGGAGGAACTATCTGAAGTAGAACAACTACAACTACAGGTGGAATTCCTAAAAAAGTATCGGAACTTGGTAAGGCAACCGACAAAGTAA","10.40","7.42","11515","MVKKAYSVETKLACIEMKKAGKSNKVIKETLRIKNDSQIYTWMRWYENDELHRFHQAVGKQYTYGKGMEELSEVEQLQLQVEFLKKYRNLVRQPTK","1294277","","transposase","Cytoplasm","Matches in gapped BLAST to hypotheticals and transposase:residues 1-68 are 58% similar to hypothetical protein from S.aureus (gi15923058).Residues 6-68 are 60% similar to transposase from Listeria monocytogenes (gi16802220).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1230 (1e-34).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-68 are 60% similar to a (PLASMID TRANSPOSASE PXO1-128 ORFA) protein domain (PD328399) which is seen in Q9XBA0_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 09:14:41 2002","Wed Mar 6 08:09:21 2002","Thu Sep 14 10:31:51 2006","Wed Mar 6 08:09:21 2002","","Wed Mar 6 08:09:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1238 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 08:09:21 2002","","No significant hits to the NCBI PDB database.","SMU.1356c","","No significant hits to the Pfam 11.0 database","Wed Mar 6 08:09:21 2002","24379767","","","","","","1","","12","SMU.1356c","937" "SMu1239","1294643","1294879","237","ATGTTTCACAAGGAAAATCCTGATTATAATCGCAAGCAATATGGCTTCTACATCCTAGCTGACCTTGTTCCAGATGACCATTTTCTCATACAAGTGGATGTAGTTAATTTTTCATTTATCTATGATTTGGTAGAAAATACTTATAGTTTCGATAATGATCGTCACAGTCTTGACCTTATCATGCTGATTAAAATTCCTCTGTTTCAGTATTTCCATATTCGCTCCATAAACCATTAA","5.40","-3.82","9497","MFHKENPDYNRKQYGFYILADLVPDDHFLIQVDVVNFSFIYDLVENTYSFDNDRHSLDLIMLIKIPLFQYFHIRSINH","1294888","","transposase fragment, IS1562 similarity","Cytoplasm","Matches in gapped BLAST to transposase:residues 1-76 are 67% similar to gi15675797 and gi3192745 from S.pyogenes.SMu1239 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 10-62 are 68% similar to a (TRANSPOSASE PXO1-120 PLASMID) protein domain (PD406209) which is seen in O69141_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 10:20:10 2002","Tue Sep 26 16:31:18 2006","Tue Sep 26 16:31:18 2006","Tue Mar 5 10:17:53 2002","","Tue Mar 5 10:17:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1239 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 10:20:10 2002","","No significant hits to the NCBI PDB database.","SMU.1357","","No significant hits to the Pfam 11.0 database","Tue Mar 5 10:17:53 2002","24379768","","","Berge,A., Rasmussen,M. and Bjorck,L.Identification of an insertion sequence located in a regionencoding virulence factors of Streptococcus pyogenesInfect. Immun. 66 (7), 3449-3453 (1998)PubMed: 9632622","","Tue Mar 5 10:20:10 2002","1","","12","SMU.1357","" "SMu1240","1294890","1294991","102","GTGAACAATGCCTACCGTTGGTTTTTCCGTTTGACTTTAGCCGATAACATGCACCGTTTTACTACTTACGGTAAGGAATGGCAGCTGTCGTTTCCAAAATAA","10.80","3.22","4121","MNNAYRWFFRLTLADNMHRFTTYGKEWQLSFPK","1295000","","transposase fragment","Extracellular, Cytoplasm","No significant hits in gapped BLAST found.SMu1240 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 10:21:20 2002","Wed May 1 16:30:48 2002","Fri Oct 18 09:13:38 2002","Tue Mar 5 10:19:01 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1240 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 10:21:20 2002","","No significant hits to the NCBI PDB database.","SMU.1358","","No significant hits to the Pfam 11.0 database","Tue Mar 5 10:19:01 2002","24379769","","","","","Tue Mar 5 10:19:31 2002","1","","12","SMU.1358","" "SMu1241","1295127","1295237","111","ATGAAATTAGCAGGAATTGAGAAAAAAATTAACCTATCAAAAAGAAGAAAACTCTATCTGGAAAATTCTTCACTACTTATAAATTATGTTAAAGTGAATATGTCTTATTAA","10.90","5.98","4241","MKLAGIEKKINLSKRRKLYLENSSLLINYVKVNMSY","1295246","","hypothetical protein","Extracellular, Cytoplasm","No significant hits in gapped BLAST found.SMu1241 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 10:22:19 2002","Tue Mar 5 10:22:19 2002","Tue Mar 5 10:22:19 2002","Tue Mar 5 10:22:19 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1241 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 10:22:19 2002","","No significant hits to the NCBI PDB database.","SMU.1359","","No significant hits to the Pfam 11.0 database","Tue Mar 5 10:22:19 2002","24379770","","","","","","1","","12","SMU.1359","" "SMu1242","1295400","1295272","129","ATGGAATTTTTGGAAAAATTTAAGGTTTTAAAACAACCGAGAAAGGCCAATAATATCAGTAAGAATCGTGTAGCCATGATTTTTCTAACCATTCATAAAAGTAGGGGCTTTCTTAGTTCGCCTTATTAG","11.50","7.22","4951","MEFLEKFKVLKQPRKANNISKNRVAMIFLTIHKSRGFLSSPY","1295287","","hypothetical protein","Periplasm, Extracellular","No significant hits in gapped BLAST found.SMu1242 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 10:23:36 2002","Tue Mar 5 10:23:36 2002","Tue Mar 5 10:23:36 2002","Tue Mar 5 10:23:36 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1242 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 10:23:36 2002","","No significant hits to the NCBI PDB database.","SMU.1360c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 10:23:36 2002","24379771","","","","","","1","","12","SMU.1360c","" "SMu1243","1295959","1295378","582","ATGAATCAATATCAAAAAACAACAGAGAGAAAAAAACAAGCTATTATTCAAGCAGCTTTGCATTTATTTAAAGAAAAAGGTTTTAAAGGGACGAGTATCAAGTCTATTGCAAAGGCAGCACAAGTATCTCCTGTTTCCATCTACAATTATTTCGAAAGTAAAGAGAGTTTAGTAGATTTATGTGTTAATAAACTATTTGAAGAAATTACACAGGAAGCTGAAAACATTTTAACCAGTGAAATAGATTTTAAGATGAAGTTATGTCAAGCTTTAGCGTTATGTCAAAAAAAAATGAGTCATCAGATTTCTGTCTATTTTAAAGAAAAAACGATAAAAGATCCTACTTTTTCAAAATTATTAACGAAAGCCATTGTTGCCAAAAAACGTGAGATTTATCGTTCTTATATTAAGCTAGGAAAAGATGAAGGAGTTATCGCTAAAGATTTGTCAACAGAACTTATATTAAACGTTATGGATGCTCTCAATAGTATTGGAAATCAATTATCAGAAAGTGAGAATTTAGGAGAAGAAATTGAACAAATTCATCGGCTTTTCTTGTATGGAATTTTTGGAAAAATTTAA","9.50","5.58","21991","MNQYQKTTERKKQAIIQAALHLFKEKGFKGTSIKSIAKAAQVSPVSIYNYFESKESLVDLCVNKLFEEITQEAENILTSEIDFKMKLCQALALCQKKMSHQISVYFKEKTIKDPTFSKLLTKAIVAKKREIYRSYIKLGKDEGVIAKDLSTELILNVMDALNSIGNQLSESENLGEEIEQIHRLFLYGIFGKI","1295393","","transcriptional regulator","Cytoplasm","Significant matches in gapped BLAST to transcription regulators: residues 1-192 are 45% similar to gi|16803756| from Listeria monocytogenes and are 42% similar to gi|16800894| from Listeria innocua. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0258 (4e-10).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[15-28]T$ $\"[36-59]T$	HTHTETR
PF00440	$\"[15-61]T$	TetR_N
PS50977	$\"[9-69]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[1-87]T$	Homeodomain_like

InterPro
IPR011075
Domain

Tetracyclin repressor-like, C-terminal
SSF48498	$\"[129-189]T$	TetR_like_C

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[2-61]T$	Homeodomain-rel

","BeTs to 8 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 3.5e-11. IPB001647 27-57","Residues 9-54 are 60% similar to a (DNA-BINDING TRANSCRIPTION REGULATION) protein domain (PD000384) which is seen in Q9KE56_BACHD.Residues 1-188 are 28% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD399721) which is seen in Q9CGX8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 13:28:59 2002","Tue Mar 5 13:27:59 2002","Fri Oct 18 09:12:39 2002","Tue Mar 5 13:27:59 2002","Tue Mar 5 13:27:59 2002","Tue Mar 5 13:27:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1243 is paralogously related (blast p-value < 1e-3) to SMu0214, SMu0539, SMu1936, SMu1294, SMu0120, SMu1069, and SMu0937, all predicted transcriptional regulators.","Tue Mar 5 13:27:59 2002","","No significant hits to the NCBI PDB database.","SMU.1361c","","Residues 15 to 61 (E-value = 8.9e-17) place SMu1243 in the TetR_N family which is described as Bacterial regulatory proteins, tetR family (PF00440)","Tue Mar 5 13:27:59 2002","24379772","","","","","","1","","12","SMU.1361c","" "SMu1244","1296881","1296600","282","ATGTTCATATTGTTGGTCAGCCTTCCACCAAGAATAAGTGTTTCAAGTTTCATGGGCTATTTAAAAGGTAAGAGTGCTCTTATGATGTTTGATAAACACGCTAATCTCAAATATAAATTTGGAAATCGCCATTTTTGGGCAGAGGGCTATTATGTGAGTACAGTGGGACTTAACGAAGCCACAATAAAGAAATATATACAAGAACAAGAAAAACATGATATCGCACTTGATAAATTGAGCGTGAAAGAATATGAAGATCCCTTTAGGGATAATGGCAAGTAA","10.00","3.71","10808","MFILLVSLPPRISVSSFMGYLKGKSALMMFDKHANLKYKFGNRHFWAEGYYVSTVGLNEATIKKYIQEQEKHDIALDKLSVKEYEDPFRDNGK","1296615","","transposase fragment (IS605/IS200-like)","Cytoplasm, Membrane","Several matches to transposase fragments in gapped BLAST. Residues 4-88 are 67% similar to gi|12584558| from Clostridium thermocellum. These residues are also 62% similar to gi|15896768| from Clostridium acetobutylicum (IS605/IS200-like).SMu1244 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002686
Family

Transposase IS200-like
PF01797	$\"[1-62]T$	Transposase_17

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-62 are 66% similar to a (TRANSPOSASE PROTEOME COMPLETE IS200) protein domain (PD003831) which is seen in Q9JWR7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 13:35:21 2002","Tue Mar 5 13:34:47 2002","Fri Oct 18 09:11:38 2002","Tue Mar 5 13:34:47 2002","","Tue Mar 5 13:34:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1244 is paralogously related (blast p-value < 1e-3) to SMu0132, a predicted transposase fragment (IS605/IS200-like) .","Tue Mar 5 13:35:21 2002","","No significant hits to the NCBI PDB database.","SMU.1363c","","Residues 1 to 62 (E-value = 7.1e-16) place SMu1244 in the Transposase_17 family which is described as Transposase IS200 like (PF01797)","Tue Mar 5 13:34:47 2002","24379773","","","","","","1","","12","SMU.1363c","" "SMu1245","1299660","1297315","2346","ATGATGAAAATTTTATTAAAAAAATTATTTAGAGATATTCGTACCAATATAGCACAATTTATAACAATTATTTTAATTGTTTCTATTGGTTCCTTTCTTTTTGTTGGCTTGTCTAGTGTTGCCAGTAGCTTAAGAGATTATACAAAAAACTACTATCATGACTATCACCTGAGCGATGCAACAGTAAATTTTATTTCGCTTACTTCAAAAAAGATAGATGCTATTAAAGATAAATATACTAATATACAAGAGGCAGAGGGACGTGTTAATTTTGAAGGAAAACAAACTTTCAAAAATTATAGCTCTGCTTTAACAATTTCTAGCTTTTCTCCTACTTCTAAGCTAAATCGTTCTTATATTGTGCAGGGAAGAAAAAAACTCAATAACAACGAAATCTTGTTAGATAGTGATTATATTAAGGCGCATCATTATAAGATGAATGATTCTATACAAATTCAAATCAATAGTAAGAAGTTCACTTTTAAAATCGCAGGAATTATTGAGAATCCTGAGTTTGTTATGAAAGTATCAGGAAATAATTTAACACCTGAGCCTCAAAAATTCGGCATAGGTTATATCACAGAACAGAAAGCTTTCGATATTTCAAAAAAAAATCATTCTTATAATCAACTTCTTTTAAAGATTAAGGGTAATAATAGTAAAAAGGTTCTTCAAAAACTTTCTGAAGATTATGATACAACTTATATTTCTGGTCTTGTTACAACTGAATCAAGTAACTACACTAATTTAAAAAGTTTAATCACAACCGATGAAAGTCTTAGCAGGGTTATTCCTATCTTATTCTTTATTGTTGCTGCGGTCATTACTTTTATTTCAATGACACGGCTCATACAACAAAACAGAGTACAGACAGGAATCATGCGCTCCTTAGGTAAAAGAATTAGATACATAAGAAGTTATTACTTATTCTATACTTTATTGACAAGTTCTATTGGGACATTTATTGGAAGTGTGCTAGCTTACTTTGCTTTTACTGATATTGGTGAAGCTCAAGTATCTTCATTGTATGCTTTACCAAATTATCATGTGAAGATTGAGTTACAATCTTTGATTCCTTCTTTTTGCCTTGTTTTATTATTTGGTTTATTAGCTATTTATTTTTCAACGCGAAAAGTTTTAAAAGAGAGACCAGCAAATTTGATTAGACAGGAGCCTCCTAAAAATATTAAAGGTATTTTATTAGAAAGGATTCCTTTCTTATGGCGGTATTTATCTTATGGAAGTAAATATGTTATTCGGAATATTTTCTTAAATAAAATACGTTTTTGCCTTAATTTACTAGGTGTTGCTTTATCTTTTTTGATGATTATATTAGCTTTTGGTTATTATAACGCTATGACTACTGTAGTTAATACGGAAATTAATGATGTCAATACTTATAATATTAGTATTATTTCTCCTAAAATTAACTCTATACAAGATAAATTATCAAATAATCCACATCTAAAGTTTGAAAAGTTAGATATTCAAAAGTTAGAACTTGGACAAGGAAATAATAGTATTGCAACGACTTTATATGCTAGTAGTCAAAAAGAGCATTTTATGAAAGTTTATAAGAAAAACGGTCAAGAATTGTCTCACTATTCAAATGGCATTGTCATACCAAAGGTTTATGCTAATAAGCTTCATTTAAAAATTGGGGATAAAGTAAGATTAGCCTTTTCAAATACTCAACAATCTCCCATAAAAGTTAGAGTAACAGCCATATCAACCCAATATTCTTCTAAATTTATTGTTGCTGACGCTGACTATTTGAAAGAACAAGGCGTTACCCTTCACCCCTCAATGCTATTAATCCAAAAAGGAAAAAATAGTAATGAAAAAACATCCCAATTAATTCAATCGGCCAAAGTTATTGATAAGGATTTAACTTATACAACTAAAAAGGATGTTCGATCAAATATGAATGCTATTTTATCAACGACATTTCCAATGGTTGTTCTATTTCTTATTTGTGCCATGTCATTAACAGTAGCGACTATTTATAATATTTCATCTATTAATATTTTTGATCGAACTAGAGATATTGCCACACTCAAAGTGTTAGGCTACTCTAAAAATAAAGTGAATAACCTTATTTTTAAGGAAAATATAATTATTTCTTGTGTAGCTATGGGCTTTGCTTTACCTGTCGGTCATTCGCTCTTTATCCTTTTTATTAACGCTATGACGACAGAACTGCAGGCTATGCCGAACGAATTACCATATTGGTGTTTTGCTTTAGCTATTGTCTGTGTTTTAGGAATCACCATTTTATCAAATTTACTTTTGCATCGAAAGGTTAAAGCCATTGATATGATTGAGGGGTTAAAGAGTATTGAATAA","10.50","41.87","88552","MMKILLKKLFRDIRTNIAQFITIILIVSIGSFLFVGLSSVASSLRDYTKNYYHDYHLSDATVNFISLTSKKIDAIKDKYTNIQEAEGRVNFEGKQTFKNYSSALTISSFSPTSKLNRSYIVQGRKKLNNNEILLDSDYIKAHHYKMNDSIQIQINSKKFTFKIAGIIENPEFVMKVSGNNLTPEPQKFGIGYITEQKAFDISKKNHSYNQLLLKIKGNNSKKVLQKLSEDYDTTYISGLVTTESSNYTNLKSLITTDESLSRVIPILFFIVAAVITFISMTRLIQQNRVQTGIMRSLGKRIRYIRSYYLFYTLLTSSIGTFIGSVLAYFAFTDIGEAQVSSLYALPNYHVKIELQSLIPSFCLVLLFGLLAIYFSTRKVLKERPANLIRQEPPKNIKGILLERIPFLWRYLSYGSKYVIRNIFLNKIRFCLNLLGVALSFLMIILAFGYYNAMTTVVNTEINDVNTYNISIISPKINSIQDKLSNNPHLKFEKLDIQKLELGQGNNSIATTLYASSQKEHFMKVYKKNGQELSHYSNGIVIPKVYANKLHLKIGDKVRLAFSNTQQSPIKVRVTAISTQYSSKFIVADADYLKEQGVTLHPSMLLIQKGKNSNEKTSQLIQSAKVIDKDLTYTTKKDVRSNMNAILSTTFPMVVLFLICAMSLTVATIYNISSINIFDRTRDIATLKVLGYSKNKVNNLIFKENIIISCVAMGFALPVGHSLFILFINAMTTELQAMPNELPYWCFALAIVCVLGITILSNLLLHRKVKAIDMIEGLKSIE","1297330","For other components see SMu1246 (NBD1).","ABC transporter permease protein","Membrane, Cytoplasm","Matches weakly in gapped BLAST to ABC transporters and to membrane protein :residues 2-781 are 22% similar to PsaB in S.mutans (gi|15625441|). Residues 37-781 are 24% similar to membrane protein in Clostridium acetobutylicum (gi|15894110|).Residues 204-781 are 25% similar to ABC transporter permease protein from Lactococcus lactis subsp. lactis (gi|15673086|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1003 (3e-46).","

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[208-384]T$ $\"[601-773]T$	FtsX

noIPR
unintegrated

unintegrated
SSF89447	$\"[520-594]T$	SSF89447

","BeTs to 13 clades of COG0577COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0577 is AMt--QVcEBRHuj--OLinxNumber of proteins in this genome belonging to this COG is 7","***** IPB003838 (DUF214) with a combined E-value of 2.2e-09. IPB003838A 668-715 IPB003838A 276-323","Residues 4-227 are 22% similar to a (PROTEOME COMPLETE) protein domain (PD213592) which is seen in O28455_ARCFU.Residues 146-448 are 22% similar to a (TRANSMEMBRANE PROTEOME MG064 MG468) protein domain (PD018584) which is seen in Q9PQH4_UREPA.Residues 3-252 are 23% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD401701) which is seen in Q9CGJ2_LACLA.Residues 255-733 are 25% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD147912) which is seen in Q9CGJ2_LACLA.","","Thu Nov 29 18:46:26 2001","Thu Nov 29 18:46:26 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:20:37 2002","Tue Mar 5 13:41:21 2002","Fri Oct 18 09:11:01 2002","Tue Mar 5 13:41:21 2002","Tue Mar 5 13:41:21 2002","Tue Mar 5 13:41:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1245 is paralogously related (blast p-value < 1e-3) to SMu1230, SMu1752, SMu1067, SMu1000,all predicted ABC transporters and SMu0787, a predicted conserved hypothetical protein.","Tue Mar 5 13:43:03 2002","","No significant hits to the NCBI PDB database.","SMU.1365c","Thu Nov 29 18:46:26 2001","Residues 208 to 384 (E-value = 1.7e-23) place SMu1245 in the FtsX family which is described as Predicted permease (PF02687)Residues 601 to 773 (E-value = 1.3e-17) place SMu1245 in the FtsX family which is described as Predicted permease (PF02687)","Tue Mar 5 13:41:21 2002","24379774","","","","Mon Oct 28 11:20:37 2002","","1","","12","SMU.1365c","" "SMu1246","1300363","1299662","702","ATGAACATTATTGAATTTAAAAGTGTATCGAAAAGATACAAAGTAGGAAATCAGGAAATTGAAGCAGTAAAGCATGTTTCATTCAACATTGAATCCGGAGAATTTGTAGTTGTTTTAGGAGCCAGTGGCGCTGGAAAAAGTACTATTCTTAATTTATTGGGGGGAATGGATACAGTATCTGAAGGTCAAATACTTGTTGAAGGACAGGATATTGTTAACTTCAGTGAAAAGGAATTAACAAAATACCGTGCTGAAAAAATTGGTTTTGTTTTTCAATTTTATAACCTTATATCAAATTTGAATACCCTAGAAAATGTGGAATTTGCCATAGAGGTATCCCAAAAATCTCTGAATCCAAAGGATATTCTAAAAAGAGTAGGATTGTCTGAACGATTAAAGAACTTTCCTTCACAACTTTCAGGAGGTGAACAACAAAGGGTATCAATAGCACGAGCCATTGCTAAAAATCCTCTGTTATTACTCTGCGATGAACCTACAGGAGCTTTAGATTATGAAACTGGGAAGGAAGTCCTTCAATTGATTAAGGAATTAAACGAAAGTACCAAAAAGAGCGTTGTTTTAATCACTCATAATAGTGCTATTTCAAAAATTGCCGATAAAGTCATTCATGTTCGAAGCGGACAAATCGAGAAAATTGAATATAATTCAGATAAAATTCCAGTTTCAGAGTTAGAGTGGTAA","5.90","-2.31","25868","MNIIEFKSVSKRYKVGNQEIEAVKHVSFNIESGEFVVVLGASGAGKSTILNLLGGMDTVSEGQILVEGQDIVNFSEKELTKYRAEKIGFVFQFYNLISNLNTLENVEFAIEVSQKSLNPKDILKRVGLSERLKNFPSQLSGGEQQRVSIARAIAKNPLLLLCDEPTGALDYETGKEVLQLIKELNESTKKSVVLITHNSAISKIADKVIHVRSGQIEKIEYNSDKIPVSELEW","1299677","For other components see SMu1245 (MSD1). ","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to ABC transporter, ATP-binding protein, e.g. residues 2-233 are 54% similar to a previously published sequence from S.mutans (gi|15625442|).Residues 2 -233 are 59% similar to the protein from Clostridium acetobutylicum (gi|15894109|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1004 (7e-73).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[138-181]T$	ABC_transporter
PF00005	$\"[33-214]T$	ABC_tran
PS00211	$\"[139-153]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-231]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[32-215]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-216]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-220]T$	PTHR19222
PTHR19222:SF32	$\"[4-220]T$	PTHR19222:SF32
SSF52540	$\"[1-216]T$	SSF52540

InterPro
IPR013216
Domain

Methyltransferase type 11
PF08241	$\"[49-148]T$	Methyltransf_11

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[35-181]T$	G3DSA:3.40.50.150
PTHR10108	$\"[35-180]T$	PTHR10108
PTHR10108:SF15	$\"[35-180]T$	PTHR10108:SF15
SSF53335	$\"[20-195]T$	SSF53335

","BeTs to 10 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 30-174 are 29% similar to a (PROTEOME YRHH COMPLETE) protein domain (PD074431) which is seen in O05400_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 15:53:35 2002","Tue Mar 5 15:53:35 2002","Tue Mar 5 15:53:35 2002","Tue Mar 5 15:53:35 2002","","Tue Mar 5 15:53:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1247 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 15:53:35 2002","","No significant hits to the NCBI PDB database.","SMU.1367c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 15:53:35 2002","24379776","","","","","","1","","12","SMU.1367c","" "SMu1248","1301468","1301587","120","ATGACTGAAATCCTTAATTTTCTGATTGCGGTACATGATGATCGTAAGAATTGGAAAATCAAACACTGTTTGTCTAATAGTTCTTTTGATTTTCTTTGCTCACCTGACAGCAGCCGATAA","7.30","0.36","4551","MTEILNFLIAVHDDRKNWKIKHCLSNSSFDFLCSPDSSR","1301596","","hypothetical protein","Extracellular, Periplasm","No significant hits in gapped BLAST found.SMu1248 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 15:55:22 2002","Tue Mar 5 15:54:45 2002","Tue Mar 5 15:54:45 2002","Tue Mar 5 15:54:45 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1248 is paralogously related (blast p-value < 1e-3) to SMu0157, a predicted hypothetical protein.","Tue Mar 5 15:55:22 2002","","No significant hits to the NCBI PDB database.","SMU.1368","","No significant hits to the Pfam 11.0 database","Tue Mar 5 15:54:45 2002","24379777","","","","","","1","","12","SMU.1368","" "SMu1249","1301828","1301950","123","ATGCCAGTCCAAAAAGCGTTACATGTTGTCTCTGCTTATGCGACAGACTTGGGCATCTGTTATGATCAAGTGGTAACTGTGATGATAAGGGAAGTGAAAACACAGCTATACCAGATTTATTAG","7.30","0.17","4571","MPVQKALHVVSAYATDLGICYDQVVTVMIREVKTQLYQIY","1301959","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.SMu1249 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 15:57:07 2002","Tue Mar 5 15:57:07 2002","Tue Mar 5 15:57:07 2002","Tue Mar 5 15:57:07 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1249 is paralogously related (blast p-value < 1e-3) to SMu0158, a predicted hypothetical protein.","Tue Mar 5 15:57:07 2002","","No significant hits to the NCBI PDB database.","SMU.1369","","No significant hits to the Pfam 11.0 database","Tue Mar 5 15:57:07 2002","24379778","","","","","","1","","12","SMU.1369","" "SMu1250","1302798","1302181","618","ATGCGTATTCTTGGTCATCACTCACCTATTCGTAAGAAGACGTATCATTCTTGTACTCAACGAGAGATAACTGAAAAGGCAAGACACGTCCACTACAACGTGCTTGCCCGAAACTTTAAAGCAGAACGCCCTCTCCAGAAACTAACAACGGATGTCAGCTACGTTTACTACAACTATGGGAGGATGTTACTGAGTGTCATAAAAGATTGTTATGACAATTCCATTTTAGACTATACGCTATCCGATTTCAATGATAACAAGTTAGTTTTTGATAATATAGATCTTGTATTTAATGATTTCTGGGATTCAACTAAGGTCTGTATTCTTCCTTCTGATCAAGGATTTCAATACACCAATCAACAATATCTTCGAAAACTAGACCAATATGGAGTGACCATTTCTCATTCTGGTAAGGGAAATGGTTACGATAATGCAGCCTGTGAGAATTTCTTTTCTCACTTGAAGAGTGAGTCCTTAAGACCATTTTCACCTAAAGACAAGAGAACACTCATCCGTCAAATTAGGGAATACATTAACTGGTATAACTACCACAGACCACAAGAGAAATTAAAAGGTATGACTCCTATGGAATTCAGGGAGTCATATCTTACTAAATAA","9.70","8.73","24438","MRILGHHSPIRKKTYHSCTQREITEKARHVHYNVLARNFKAERPLQKLTTDVSYVYYNYGRMLLSVIKDCYDNSILDYTLSDFNDNKLVFDNIDLVFNDFWDSTKVCILPSDQGFQYTNQQYLRKLDQYGVTISHSGKGNGYDNAACENFFSHLKSESLRPFSPKDKRTLIRQIREYINWYNYHRPQEKLKGMTPMEFRESYLTK","1302196","","transposase, IS861, IS3 family","Cytoplasm, Extracellular","This sequence was previously published in GenBank as gi3873218, a predicted transposase. Residues 134-204 are 39% similar to transposase from S.mutansFurthermore, residues 1-201 are 39% similar to gi1749770, a predicted transposase from B.thuringiensis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (5e-25).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[40-200]T$	rve
PS50994	$\"[40-203]T$	INTEGRASE

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[35-195]T$	RNaseH_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.10	$\"[35-196]T$	G3DSA:3.30.420.10

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 134-199 are 48% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in P94597_BACTU.Residues 53-131 are 35% similar to a (TRANSPOSASE PLASMID) protein domain (PD188994) which is seen in P94597_BACTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 09:09:12 2002","Tue Sep 26 14:57:06 2006","Tue Sep 26 14:56:28 2006","Tue Mar 5 16:03:08 2002","","Tue Mar 5 16:03:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1250 is paralogously related (blast p-value < 1e-3) to SMu0798, SMu1719, SMu1283, SMu1258, SMu0695, SMu0395, SMu0514, and SMu1236, all transposase-related.","Tue Mar 5 16:03:08 2002","","No significant hits to the NCBI PDB database.","SMU.1370c","","Residues 40 to 200 (E-value = 7.2e-24) place SMu1250 in the rve family which is described as Integrase core domain (PF00665)","Tue Mar 5 16:03:08 2002","24379779","","","Dunn,M.G. and Ellar,D.J.Identification of two sequence elements associated with the geneencoding the 24-kDa crystalline component in Bacillus thuringiensis ssp. fukuokaensis: an example of transposable element archaeologyPlasmid 37 (3), 205-215 (1997)PubMed: 9200224","","Tue Mar 5 16:03:08 2002","1","","12","SMU.1370c","" "SMu1251","1303802","1303560","243","ATGAAACAAGGACGCAAGACAACTTTTGAAGGACGTATTGAAATTGTCACTTTCACAATGGTTCACAATAAGAACTATCACGCGGCGGTTGAGAAGTATGGGGGCTCTTACCAACAAGTTTACTCATGGGTGAGAAAGTTTAAGAAAGATGGCATCAATGGACTATTAGACCGACGTGGAAAAGGTCTTGAAAGCAAACTAATATCCGTCGTTATGGTGGCTATTGTACTAAGACCAGTTTGA","11.00","9.46","9156","MKQGRKTTFEGRIEIVTFTMVHNKNYHAAVEKYGGSYQQVYSWVRKFKKDGINGLLDRRGKGLESKLISVVMVAIVLRPV","1303575","","transposase, IS861, IS3 family","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0610 (7e-23).","

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[3-60]T$	Homeodomain_like

InterPro
IPR007344
Family

Protein of unknown function UPF0157
PF04229	$\"[1-180]T$	UPF0157

noIPR
unintegrated

unintegrated
SSF81301	$\"[21-143]T$	SSF81301

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 39-173 are 36% similar to a (PA4798 GLNQ-ANSR BH1888 TRANSFERASE) protein domain (PD035421) which is seen in GRPB_BACFI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 18:12:55 2002","Mon Oct 28 18:12:55 2002","Mon Oct 28 18:12:55 2002","Wed Mar 6 08:16:40 2002","","Wed Mar 6 08:16:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1254 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 28 18:12:55 2002","","No significant hits to the NCBI PDB database.","SMU.1375c","","Residues 1 to 180 (E-value = 3.3e-33) place SMu1254 in the UPF0157 family which is described as Uncharacterised protein family (UPF0157) (PF04229)","Wed Mar 6 08:16:40 2002","24379783","","","","","","1","","12","SMU.1375c","" "SMu1255","1306586","1305801","786","ATGACTAAACATATCCATTGGGATGGCAATCTTTCACAAGAAGGCTTTGAAATTGTTAAGGGCGAAGGCGGTGTAATCGTTTGTCCAACTAAGGTTGGCTACATTATCATGACTTCAGATAAAAAAGGTCTCGAACGTAAATTTGAAGCTAAAAAGCGCAATCGCAACAAACCTGGGGTTGTCCTTTGCGGCAGTATGGAAGAATTGCGTGCCTTAGCCCAGTTAACACCAGAAATTGATGCCTTTTATCAAAAACATTGGGATGAAGATATCCTTCTTGGCTGTATCTTACCATGGAAAGCAGAAGCTTACGAAAAATTGAAAGCTTATGGCGATGGACGTGAAGAACTGATGACAGATATTCGCGGCACCTCTTGTTTTGTTATTAAATTTGGCGTGGCTGGCGAGCAAATTGCCAAAGAAATGTGGGAAAAAGAAGGCCGTATGGTTTATGCTTCCTCTGCTAATCCATCAGGTAAAGGGAACCGCGGTAAAGTGGAAGGTATTGGTGAACGTATCGAATCCATGGTTGACCTTGTTATTGAAGCTGATGATTATGTCGCTTCTATCCAGCCTGATAAGACAATTGAAACGCGCTATGAGCAAGGTGTTATGGTCTCAATGGTTGATAAAGACGGCAAATTAATCCCGCAACAAGGAGCGGATAGCCGTTCAGTAGAGCCGTGCCCTGTTGTTATCCGTAAGGGTCTTGATATTGATAAAATCATGATGCACCTATCAGATCAGTTCAACTCTTGGAATTACCGACAAGGTGAGTATTATTAA","5.40","-5.25","29425","MTKHIHWDGNLSQEGFEIVKGEGGVIVCPTKVGYIIMTSDKKGLERKFEAKKRNRNKPGVVLCGSMEELRALAQLTPEIDAFYQKHWDEDILLGCILPWKAEAYEKLKAYGDGREELMTDIRGTSCFVIKFGVAGEQIAKEMWEKEGRMVYASSANPSGKGNRGKVEGIGERIESMVDLVIEADDYVASIQPDKTIETRYEQGVMVSMVDKDGKLIPQQGADSRSVEPCPVVIRKGLDIDKIMMHLSDQFNSWNYRQGEYY","1305816","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 1-261 are 86% similar to S.gordonii (gi|13507083|) and residues 37-83 are 82% similar to S.pneumoniae (gi|15901113|).SMu1255 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006070
Domain

SUA5/yciO/yrdC, N-terminal
PS51163	$\"[9-215]T$	YRDC

noIPR
unintegrated

unintegrated
SSF55821	$\"[1-244]T$	SSF55821

","BeTs to 6 clades of COG0009COG name: Putative translation factor (SUA5)Functional Class: JThe phylogenetic pattern of COG0009 is amtkyqvCEbrH----olinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 08:21:18 2002","Wed Mar 6 08:21:18 2002","Wed Mar 6 08:21:18 2002","Wed Mar 6 08:21:18 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1255 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 08:21:18 2002","","No significant hits to the NCBI PDB database.","SMU.1377c","","No significant hits to the Pfam 11.0 database","Wed Mar 6 08:21:18 2002","24379784","","","","","","1","","12","SMU.1377c","" "SMu1256","1306651","1307187","537","ATGAAAATCAAACGCTATTTTCCTCCCAAAAGGCAAGTTTATAGTCTTCTAAAGATGCTGTTCTTGCAAATTACTGTCTCGGAAAATGGTTATAGCACAAAAATGACAAGCTTTGATGACTATCTCACTAAAGCAAATCAGTTAGAACAAAAATTACTCATTGAAATCAAAACATCTTCTCAAGATTCAAAGAAGATAATGGCACATTTTCTCAACAAATACGCTAAACCAATCAAACATCAGATTCATTCGCTTGATTACCATCTCATTGATAAGGTTAAAAAATATGATAAATCTCTTGTCGCTTACTTCATCCTTCCTTATAAGTCTATCTTCTCCAGAACCAAAGCCAACGGCTATACGATGGAATACTTTTCCTTAGACCAAAATTTCATGACCAAACTGCTGACCAATCATAAGAAGATTTACGCTTGGACAGTCAACAATGAATCAGTAATGACAGGGATGATTTTGATGGGTGTCAATGGCATTATTACAGATTACCTAACCACTTCCCAAGGAGAAAATCAAAGATAG","10.50","13.19","20895","MKIKRYFPPKRQVYSLLKMLFLQITVSENGYSTKMTSFDDYLTKANQLEQKLLIEIKTSSQDSKKIMAHFLNKYAKPIKHQIHSLDYHLIDKVKKYDKSLVAYFILPYKSIFSRTKANGYTMEYFSLDQNFMTKLLTNHKKIYAWTVNNESVMTGMILMGVNGIITDYLTTSQGENQR","1307196","","hypothetical protein","Extracellular","Limited matches in gapped BLAST to hypothetical proteins: residues 24-175 are 52% similar to S.pneumoniae (gi|15902941|) and residues 26-169 are 42% similar to Lactococcus lactis (gi|15673979|). SMu1256 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004129
Family

Glycerophosphoryl diester phosphodiesterase
PF03009	$\"[141-171]T$	GDPD

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.190	$\"[34-171]T$	G3DSA:3.20.20.190
SSF51695	$\"[32-177]T$	SSF51695

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 26-90 are 48% similar to a (PHOSPHODIESTERASE PROTEOME COMPLETE) protein domain (PD088163) which is seen in Q9CE50_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon May 6 10:39:41 2002","Mon May 6 10:39:41 2002","Wed Mar 6 08:25:38 2002","Wed Mar 6 08:25:38 2002","","Wed Mar 6 08:25:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1256 is paralogously related (blast p-value < 1e-3) to SMu0661, a predicted glycerophosphodiester phosphodiesterase.","Wed Mar 6 08:25:38 2002","","No significant hits to the NCBI PDB database.","SMU.1378","","No significant hits to the Pfam 11.0 database","Wed Mar 6 08:25:38 2002","24379785","","","","","","1","","12","SMU.1378","" "SMu1257","1307343","1307861","519","ATGAAATTGACTTATGAAGATAAAGTTCTCATCTATGAACTGAAAAACCAAGGGTATAGCTTAGAGCAGCTTTCAAATAAATTTGGGATAAAAATTTCTAATCTTAGCTACATGATTAAATTGATTGATCATTACGGAATAGAGATCGTCAAAAAAGGAAAGAATCGTTACTATTCTCCTGAACTAAAACAAGAAATCATTGATAAAGTTCTTCTTGAAGGTCGTTCACAAATAAGGGTGTCTCTAGATTATGCTCTTCCAAGTCATGGAATGTTGCCTAATTGGATAGCACAATACAAGAAAAATAGGTATACTATTGTTGAGAAAACAAGAGGGAGACCACCTAAAATGGGACGTAAGCCAAAGAAGAAATCGGAAGAAATGACAGAGCTAGAGCAACTTCAGAAAGAATTAGAATATCTGAGAGCGGAGAATGCTGTTCTAAAAAAGTTGAGAGAACTCCGATTGAGGGAAGAAAAAGAGCAAGAAGAAAAACGGAAATTGTCCGAGGATTGGTAA","10.40","10.49","20606","MKLTYEDKVLIYELKNQGYSLEQLSNKFGIKISNLSYMIKLIDHYGIEIVKKGKNRYYSPELKQEIIDKVLLEGRSQIRVSLDYALPSHGMLPNWIAQYKKNRYTIVEKTRGRPPKMGRKPKKKSEEMTELEQLQKELEYLRAENAVLKKLRELRLREEKEQEEKRKLSEDW","1307870","","transposase, IS861-associated, IS3 family","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and IS861 associated segments:residues 1-108 are 73% similar to the hypothetical protein in S.pneumoniae (gi8163692) and are 62% similar to the conserved hypothetical protein, IS861 associated in S.pyogenes (gi15674401). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1526 (9e-37).","

InterPro
IPR002514
Family

Transposase IS3/IS911
PF01527	$\"[55-148]T$	Transposase_8

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[3-96]T$	Homeodomain_like

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 38-108 are 67% similar to a (DOMAIN OF UNKNO N) protein domain (PD354820) which is seen in Q53639_STRAG.Residues 1-37 are 78% similar to a (DOMAIN OF UNKNO N) protein domain (PD230559) which is seen in Q9KK22_STRPN.","","Thu Nov 29 18:48:15 2001","Thu Nov 29 18:48:15 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 3 15:43:21 2003","Tue Sep 26 14:57:40 2006","Tue Sep 26 14:53:45 2006","Wed Mar 6 08:30:35 2002","","Wed Mar 6 08:30:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1257 is paralogously related (blast p-value < 1e-3) to SMu1720, SMu1284, SMu0694, SMu0515, and SMu0396, all predicted conserved hypotheticals,possibly transposon IS861 associated.","Wed Mar 6 08:30:35 2002","","No significant hits to the NCBI PDB database.","SMU.1379","Thu Nov 29 18:48:15 2001","Residues 55 to 148 (E-value = 5.3e-06) place SMu1257 in the Transposase_8 family which is described as Transposase (PF01527)","Wed Mar 6 08:30:35 2002","24379786","","","","","","1","","12","SMU.1379","" "SMu1258","1307855","1308691","837","TTGGTAACGGAGTTTTCTTTAGACATTCTTCTAAAGATTATTAAGCTCGCTCGTTCAACCTATTATTACCACTTAAAGCAGCTAGATAAAAGCAATAAAGATCATGCTATTAAAGCTGAAATTCAAGCTATTTTTACTGAGCACAAAGGAAATTATGGTTATCGTCGAATGACTCTTGAATTGAGAAATCGTGGCTTCTTGGTAAATCATAAAAAGGTTCAACGTCTAATGAAAGTTCTTGGTTTGGAGGCTCGTATTCGTCGCAAACGGAAGTATTCTTCCTACCAAGGAGAGGTGGGCAAGAAAGCAGACAACCTTATTCAACGCCAATTTGAAGCATCAAAACCAATGGAAAAGTGCTACACAGATGTGACAGAATTTGCCATTCCAGCAAGCGGTCAAAAGCTCTATTTGTCACCAGTTTTAGATGGTTTCAACAGTGAAATTATTGCTTATAACCTTTCTACGTCACCGAACTTGATACAAGTGAAAGCTATGCTAGAACAGGCTTTCACAGAGAAACATTACACAAATACTATTCTTCATAGTGACCAAGGCTGGCAATACCAGCATGATTTTTATCATCAATTTTTAGAGAACAAGGGGATTCAGCCGTCCATGTCACGTAAAGGAAACAGCCCAGATAATGGCATGATGGAATCTTTCTTTGGCATTTTGAAATCCGAAATGTTTTACGGTTATGAGAAGACATTTAAGTCACTTAAGCAATTGGAACAAGCTATTGTAGACTATATTGATTATTACAACAACAAACGTATTAAGGTAAAACTAAAAGGACTTAGTCCTGTACAGTACAGAACGAAATCCTTTACTTAA","10.40","17.88","32568","LVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGNYGYRRMTLELRNRGFLVNHKKVQRLMKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQFEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIAYNLSTSPNLIQVKAMLEQAFTEKHYTNTILHSDQGWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT$","1308700","","transposase, IS3-Spn1","Cytoplasm","This sequence was previously published in GenBank as gi3873218, a predicted transposase. Residues 203-277 are 97% similar to residues 1-75 of gi3873218.Furthermore, residues 1-276 are 84% similar to gi8163693, a predicted IS3-Spn1 transposase. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (1e-122).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[111-273]T$	rve
PS50994	$\"[111-276]T$	INTEGRASE

noIPR
unintegrated

unintegrated
PD688335	$\"[34-75]T$	Q8DVC7_STRMU_Q8DVC7;
G3DSA:3.30.420.10	$\"[136-277]T$	no description
signalp	$\"[1-18]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 230-272 are 51% similar to a (ELEMENT ORFB B. CRYIIB) protein domain (PD410106) which is seen in Q57057_BACAN.Residues 162-202 are 82% similar to a (TRANSPOSASE ELEMENT COMPLETE) protein domain (PD335900) which is seen in Q9KK23_STRPN.Residues 121-161 are 95% similar to a (TRANSPOSASE ELEMENT INSERTION COMPLETE) protein domain (PD006527) which is seen in Q9KK23_STRPN.Residues 11-149 are 27% similar to a (TRANSPOSASE) protein domain (PD102854) which is seen in Q48525_LACCA.Residues 58-118 are 73% similar to a (TRANSPOSASE COMPLETE ELEMENT OF) protein domain (PD245714) which is seen in Q9KK23_STRPN.Residues 205-272 are 95% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in Q9KK23_STRPN.Residues 205-255 are 86% similar to a (TRANSPOSASE PLASMID COMPLETE OF) protein domain (PD000334) which is seen in Q53640_STRAG.Residues 4-55 are 76% similar to a (TNIA ISTB TNIBDELTA1 COMPLETE) protein domain (PD402756) which is seen in Q9KK23_STRPN.Residues 124-197 are 41% similar to a (TRANSPOSASE OF PROTEOME COMPLETE) protein domain (PD395630) which is seen in O50351_LACHE.Residues 9-55 are 48% similar to a (TRANSPOSASE ELEMENT PROTEOME FOR) protein domain (PD195495) which is seen in INSK_ECOLI.","","Tue Nov 20 14:43:02 2007","Tue Nov 20 14:43:02 2007","Tue Nov 20 14:43:02 2007","Tue Nov 20 14:43:02 2007","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","Tue Nov 20 14:43:02 2007","Tue Nov 20 14:43:02 2007","","Fri Oct 18 09:08:21 2002","Wed Mar 6 08:37:14 2002","Tue Sep 26 14:58:39 2006","Wed Mar 6 08:37:14 2002","","Wed Mar 6 08:37:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1258 is paralogously related (blast p-value < 1e-3) to SMu1719, SMu1283, SMu0695, SMu0395, SMu0514, SMu0798, SMu1250, SMu0934, SMu0537, SMu1237, SMu1236, and SMu1235,all transposase-related.","Wed Mar 6 08:37:14 2002","","No significant hits to the NCBI PDB database.","SMU.1380","Thu Nov 29 18:49:08 2001","Residues 111 to 273 (E-value = 1.2e-40) place SMu1258 in the rve family which is described as Integrase core domain (PF00665)","Wed Mar 6 08:37:14 2002","","","","Rubens,C.E., Heggen,L.M. and Kuypers,J.M.IS861, a group B streptococcal insertion sequence related to IS150and IS3 of Escherichia coliJ. Bacteriol. 171 (10), 5531-5535 (1989)PubMed: 2477359","Tue Sep 26 14:58:39 2006","Tue Nov 20 14:19:22 2007","1","","12","SMU.1380","" "SMu1259","1309390","1308800","591","ATGGAAGAATTTACAATTTATACAGGAACAACGGTTCCTTTAATGAATGATAATATTGATACCGATCAAATTTTGCCTAAGCAATTTCTGAAACTCATTGATAAAAAAGGTTTTGGAAAATATCTGATGTATGAGTGGCGGTATTTGGATAATAATTATACAGAAAATCCAGATTTTATTTTTAATCAACCAGAATACCGCGAGGCGAGTATTTTAATTACAGGTGATAACTTTGGAGCAGGTTCTTCAAGGGAACATGCAGCTTGGGCTTTGGCTGATTATGGGTTTAAAGTTATTGTAGCTGGCTCTTTTGGAGATATTCACTATAATAATGATTTGAATAATGGTATTTTGCCCATTATCCAGCCTAAGGAAGTTCGAGATAAACTGGCTAAATTAAAACCGACAGATGAAGTAACCGTTAATCTTTTTGAACAAAAAATCTATTCTCCCGTAGGAGATTTTTCCTTTGATATTGATGGGGAATGGAAACATAAACTATTAAATGGACTTGATGACATTGGAATCACTCTTCAGTATGAAGACCTGATTGCACAGTATGAGCAAAACCGTCCAAGCTATTGGCACTAA","4.50","-12.03","22674","MEEFTIYTGTTVPLMNDNIDTDQILPKQFLKLIDKKGFGKYLMYEWRYLDNNYTENPDFIFNQPEYREASILITGDNFGAGSSREHAAWALADYGFKVIVAGSFGDIHYNNDLNNGILPIIQPKEVRDKLAKLKPTDEVTVNLFEQKIYSPVGDFSFDIDGEWKHKLLNGLDDIGITLQYEDLIAQYEQNRPSYWH","1308815","For other 'leu' genes see SMu1766 (leuRS); SMu1260 (leuC); SMu1261 (leuB) and SMu1262 (leuA).For alpha-isopropylmalate isomerase large subunit see SMu1260.","3-isopropylmalate dehydratase, small subunit","Cytoplasm","Matches in gapped BLAST to 3-isopropylmalate dehydratase small subunit:residues 69-120 are 44% similar to the previously published enzyme aconitase in S.mutans (gi:1421812). Residues 1-195 are 86% similar to alpha-isopropylmalate isomerase small subuni in S.gordonii (gi:13507082) and residues 1-189 are 68% similar to the enzyme from Lactococcus lactis (gi:15673203). SMu1259 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000573
Domain

Aconitate hydratase, C-terminal
PF00694	$\"[1-125]T$	Aconitase_C

InterPro
IPR004431
Domain

3-isopropylmalate dehydratase small subunit region
TIGR00171	$\"[1-184]T$	leuD

InterPro
IPR012305
Family

3-isopropylmalate dehydratase small subunit
PIRSF001420	$\"[1-196]T$	LeuD

noIPR
unintegrated

unintegrated
G3DSA:3.20.19.10	$\"[14-148]T$	G3DSA:3.20.19.10
PTHR11670	$\"[39-196]T$	PTHR11670
PTHR11670:SF2	$\"[39-196]T$	PTHR11670:SF2
SSF52016	$\"[1-196]T$	SSF52016

","BeTs to 11 clades of COG0066COG name: 3-isopropylmalate dehydratase small subunitFunctional Class: EThe phylogenetic pattern of COG0066 is AMTkyqVcEbrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB000573 (Aconitase C-terminal domain) with a combined E-value of 9.2e-32. IPB000573 71-120","Residues 75-131 are 44% similar to a (HYDRATASE ACONITATE ACONITASE LYASE IRON-SULFUR CITRATE) protein domain (PD001077) which is seen in O67656_AQUAE.Residues 1-62 are 79% similar to a (ISOMERASE DEHYDRATASE 3-ISOPROPYLMALATE) protein domain (PD018132) which is seen in LEUD_LACLA.Residues 1-72 are 43% similar to a (ISOMERASE SUBUNIT LYASE ALPHA-IPM) protein domain (PD406819) which is seen in LEUD_ALCEU.Residues 73-189 are 64% similar to a (ISOMERASE DEHYDRATASE 3-ISOPROPYLMALATE LYASE SUBUNIT) protein domain (PD189850) which is seen in LEUD_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 24 11:28:49 2005","Tue May 24 11:28:49 2005","Tue May 24 11:28:49 2005","Wed Mar 6 08:40:14 2002","Wed Mar 6 08:40:14 2002","Wed Mar 6 08:40:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1259 is paralogously related (blast p-value < 1e-3) to SMu0612, a predicted aconitate hydratase; aconitase.","Wed Mar 6 08:51:38 2002","","No significant hits to the NCBI PDB database.","SMU.1381c","","Residues 1 to 125 (E-value = 4.5e-57) place SMu1259 in the Aconitase_C family which is described as Aconitase C-terminal domain (PF00694)","Wed Mar 6 08:40:14 2002","","","","Miyazaki J, Nakaya S, Suzuki T, Tamakoshi M, Oshima T,Yamagishi A.Ancestral residues stabilizing 3-isopropylmalate dehydrogenase of an extreme thermophile: experimental evidence supporting the thermophilic common ancestor hypothesis.J Biochem (Tokyo). 2001 May;129(5):777-82.PMID: 11328601 Oultram JD, Loughlin M, Walmsley R, Gunnery SM, Minton NP.The nucleotide sequence of genes involved in the leucine biosynthetic pathway of Clostridium pasteurianum.DNA Seq. 1993;4(2):105-11.PMID: 8173074 ","","Wed Mar 6 08:48:16 2002","1","","","SMU.1381c","" "SMu1260","1310777","1309392","1386","ATGAGTGGAAAATCAATTTTTGATAAATTATGGGATCGCCATGTGATTACCGGTAAGGAAGGAGAGCCCCAACTCATGTATGTGGATCAGCACTATATACATGAGGTGACTAGCCCGCAAGCCTTTCAGGGCTTGCGAGATGCTGGTCGAAAAGTGCGCCGTCCTGATTTAACTTTTGGAACATTTGATCACAATGTACCGACCGTTAATATTTATGATATTCGTGATGTTATTTCTAAGGCACAAATGGATGCTCTTGCTAGAAATGTTATCGAATTTAATATTCCTCATGCAGACCATGGTTCTGAAAATCAGGGAATTGTCCATATGGTTGGCCCTGAGACTGGTCGTACACAGCCGGGTAAATTTATCGTTTGCGGAGATAGCCATACGGCAACACATGGCGCTTTTGGTGCTATTGGTTTTGGAATTGGAACTACCGAAGTTGAGCATGTTTTTGCGACCCAGACTATCTGGCAGGTAAAACCTAAAAAGCTCTTGGTAAAATTTACAGGAAAACCACAAAAGGGTGTTTATTCCAAGGATTACATTTTAGCCTTAATTGCTAAATATGGTGTGGCTTTAGGTGTTGGTTATGTTGTTGAGTATATTGGTGATGCTGTTGATGCCCTAAGCATGGAAGAACGAATGACTATATGCAATATGTCCATAGAATTTGGTTCTAAAATGGGAATTATGAATCCTGATCAAAAGACCTTTGATTACCTTAAGAACAAAGCGTGTGTCCCTGAAGATTTTGAAACAGCAGTGGCTGATTGGAAGACTTTGGTTTCTGATGAAGATGCTCATTACGACAAGGTGATTGAATTAGATGTTTCTCAATTAGCTCCCATGGTGACTTGGGGAACTAATCCTTCAATGGGAGTCGCTTTTGGGCAAGCTTTTCCTGATATTAGAGATATGAATGATAAGCGGGCTTATGATTATATGGACATGAAGCCGGGCCAAACAGCAGAGGATATTGAACTTGGTTATGTTTTTTTAGGTTCTTGTACCAATGCGCGATTAAGTGATTTGAAAGTGGCAGCTAAGTACGTTGCTGGTAAACATATTGCTCCTAATTTGACCGCTATTGTGGTTCCGGGCAGCCGTCCTGTCAAGCAGGCTGCTGAAAAAATTGGTCTGGATAAAATTTTCTTAGATGCTGGCTTTGAATGGCGCGATCCGGGCTGTTCCATGTGTCTTGGTATGAATCCTGATAAGGTACCTGAAGGCATGCACTGTGCTTCAACTAGCAATCGTAATTTTGAAGATAGACAGGGAGTTGGAGCGAAAACACACCTTTGCAGCCCTGCTATGGCAGCAGCAGCAGCAATTGCTGGTCGCTTTATAGATGTTCGTCAATTACCGGAGGCACAAGTTTAA","6.20","-6.98","50609","MSGKSIFDKLWDRHVITGKEGEPQLMYVDQHYIHEVTSPQAFQGLRDAGRKVRRPDLTFGTFDHNVPTVNIYDIRDVISKAQMDALARNVIEFNIPHADHGSENQGIVHMVGPETGRTQPGKFIVCGDSHTATHGAFGAIGFGIGTTEVEHVFATQTIWQVKPKKLLVKFTGKPQKGVYSKDYILALIAKYGVALGVGYVVEYIGDAVDALSMEERMTICNMSIEFGSKMGIMNPDQKTFDYLKNKACVPEDFETAVADWKTLVSDEDAHYDKVIELDVSQLAPMVTWGTNPSMGVAFGQAFPDIRDMNDKRAYDYMDMKPGQTAEDIELGYVFLGSCTNARLSDLKVAAKYVAGKHIAPNLTAIVVPGSRPVKQAAEKIGLDKIFLDAGFEWRDPGCSMCLGMNPDKVPEGMHCASTSNRNFEDRQGVGAKTHLCSPAMAAAAAIAGRFIDVRQLPEAQV","1309407","For other 'leu' genes see SMu1766 (leuRS); SMu1259 (leuD); SMu1261 (leuB) and SMu1262 (leuA). For alpha-isopropylmalate isomerase small subunit see SMu1259.","alpha-isopropylmalate isomerase large subunit","Cytoplasm","Several matches in gapped BLAST to alpha-isopropylmalate isomerase large subunit: residues 5-460 are 80% similar to the enzyme in S.gordonii (gi|13507081|). Residues 1-456 are 66% similar to the protein from Lactococcus lactis (gi|486726|).SMu1260 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001030
Domain

Aconitate hydratase, N-terminal
PD000511	$\"[106-449]T$	Aconitase_N
PR00415	$\"[82-95]T$ $\"[108-116]T$ $\"[119-132]T$ $\"[133-148]T$ $\"[195-208]T$ $\"[209-222]T$ $\"[284-298]T$ $\"[334-345]T$ $\"[390-403]T$	ACONITASE
PF00330	$\"[5-448]T$	Aconitase
PS00450	$\"[330-346]T$	ACONITASE_1
PS01244	$\"[390-403]T$	ACONITASE_2
SSF53732	$\"[2-456]T$	Aconitase_N

InterPro
IPR004430
Domain

3-isopropylmalate dehydratase large subunit region
TIGR00170	$\"[2-456]T$	leuC

InterPro
IPR012095
Family

3-isopropylmalate dehydratase large subunit
PIRSF006442	$\"[4-458]T$	LeuC

noIPR
unintegrated

unintegrated
G3DSA:3.30.499.10	$\"[26-164]T$ $\"[318-456]T$	G3DSA:3.30.499.10
G3DSA:3.40.1060.10	$\"[166-279]T$	G3DSA:3.40.1060.10
PTHR11670	$\"[1-312]T$ $\"[330-458]T$	PTHR11670
PTHR11670:SF6	$\"[1-312]T$ $\"[330-458]T$	PTHR11670:SF6

","BeTs to 11 clades of COG0065COG name: 3-Isopropylmalate dehydratase large subunitFunctional Class: EThe phylogenetic pattern of COG0065 is AMTkyqVcEbrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001030 (Aconitase (aconitate hydratase)) with a combined E-value of 6.9e-41. IPB001030A 195-243 IPB001030B 380-403 IPB001030C 415-429 IPB001030A 135-183","Residues 1-40 are 47% similar to a (ISOMERASE 4FE-4S LARGE SUBUNIT) protein domain (PD137565) which is seen in LEU2_AZOVI.Residues 337-448 are 34% similar to a (LYASE ACONITASE IRON-SULFUR PEPTIDE) protein domain (PD355973) which is seen in LYS4_EMENI.Residues 105-235 are 30% similar to a (HACA) protein domain (PD299828) which is seen in Q9ZNE0_THETH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 09:07:49 2002","Wed Mar 6 08:50:13 2002","Fri Oct 18 09:07:49 2002","Wed Mar 6 08:50:13 2002","Wed Mar 6 08:50:13 2002","Wed Mar 6 08:50:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1260 is paralogously related (blast p-value < 1e-3) to SMu0612, a predicted aconitate hydratase; aconitase.","Wed Mar 6 08:55:10 2002","Wed Mar 6 08:50:13 2002","pdb|1B0M|A Chain A, Aconitase R644q:fluorocitrate Complex 98 3e-021pdb|1B0J|A Chain A, Crystal Structure Of Aconitase With Isocitr... 98 3e-021pdb|1C97|A Chain A, S642a:isocitrate Complex Of Aconitase >gi|6... 98 3e-021","SMU.1382c","","Residues 5 to 448 (E-value = 2.6e-223) place SMu1260 in the Aconitase family which is described as Aconitase family (aconitate hydratase) (PF00330)","Wed Mar 6 08:50:13 2002","","","","Godon,J.J., Chopin,M.C. and Ehrlich,S.D.Branched-chain amino acid biosynthesis genes in Lactococcus lactissubsp. lactisJ. Bacteriol. 174 (20), 6580-6589 (1992)PubMed: 1400210Godon,J.J., Delorme,C., Bardowski,J., Chopin,M.C., Ehrlich,S.D. and Renault,P.Gene inactivation in Lactococcus lactis: branched-chain amino acidbiosynthesisJ. Bacteriol. 175 (14), 4383-4390 (1993)PubMed: 8331070","","Wed Mar 6 08:55:10 2002","1","","","SMU.1382c","" "SMu1261","1311937","1310903","1035","ATGAAAAAAATCGTAACGCTGGCAGGAGATGGTATTGGTCCAGAAATTATGGCAGCAGGTTTAGAGGTTTTTGACGCTGTTGCTCAAAAGATTAACTTTGACTATGAAATTGAAGCAAAAGCTTTTGGAGGTGCAGGAATTGATGCCAGTGGGCATCCGCTTCCTGATGATACCTTAGCAGCAGCAAAAACTGCTGATGCGATTCTATTGGCGGCCATTGGCAGTCCGCAATACGACAAGGCACCTGTTCGTCCGGAACAAGGTCTGTTAGCTATACGTAAAGAACTTAATCTTTTTGCTAATATTCGTCCAGTGCGTATTTTTGATGCCCTCAGGCACTTATCGCCTTTAAAAGCAGAACGTATTGCTGGTGTTGATTTTGTGGTTGTTCGTGAATTGACTGGTGGTATCTACTTTGGTCAACATACTTTAACTGAAAATTCGGCATGTGATATTAATGAGTACTCAGCTAGTGAAATCCGTCGAATTATGCGTAAGGCCTTTGCCATTGCACGTGGTCGCAGTAAAAAAGTAACCAGTATTGATAAGCAAAATGTTTTGGCGACTTCAAAGCTTTGGCGACAGATAGCAGAAGAAGTAGCAAAAGAATATTCAGATGTCACTTTGGAGCATCAATTGGTGGACAGTGCAGCCATGGTTATGATTACTAATCCAGCTTGTTTTGATGTTGTAGTGACTGAAAATCTTTTTGGGGATATTCTGTCCGATGAATCCAGTGTACTGCCTGGCACCTTAGGGGTCATGCCGTCTGCCAGTCATTCAGAAAGCGGTCCTAGCCTTTATGAACCCATTCACGGTTCAGCACCTGATATTGCTGGAAAAGGTATTGCTAACCCAATTTCTATGATTTTATCAGTTGCTATGATGCTGCGTGACAGTTTCGGAGAAACTGCTGGTGCTGAAATGATTGAACACGCTGTTAATAAAACCTTGACGCAGGGGATTCTAACGCGTGATTTAGGCGGTTTGGCTAATACAAAACAGATGACAGCTGCTATTATTGCCAATCTCTAA","5.20","-8.39","36688","MKKIVTLAGDGIGPEIMAAGLEVFDAVAQKINFDYEIEAKAFGGAGIDASGHPLPDDTLAAAKTADAILLAAIGSPQYDKAPVRPEQGLLAIRKELNLFANIRPVRIFDALRHLSPLKAERIAGVDFVVVRELTGGIYFGQHTLTENSACDINEYSASEIRRIMRKAFAIARGRSKKVTSIDKQNVLATSKLWRQIAEEVAKEYSDVTLEHQLVDSAAMVMITNPACFDVVVTENLFGDILSDESSVLPGTLGVMPSASHSESGPSLYEPIHGSAPDIAGKGIANPISMILSVAMMLRDSFGETAGAEMIEHAVNKTLTQGILTRDLGGLANTKQMTAAIIANL","1310918","For other 'leu' genes see SMu1766 (leuRS); SMu1259 (leuD); SMu1260 (leuC) and SMu1262 (leuA). ","3-isopropylmalate dehydrogenase","Cytoplasm","Several matches in gapped BLAST to 3-isopropylmalate dehydrogenase :residues 90-337 are 31% similar to the previously published enzyme isocitrate dehydrogenase in S.mutans (gi|1421814|). Residues 2-344 are 72% similar to 3-isopropylmalate dehydrogenase from S.pneumoniae (gi|15903178|).Residues 2-343 are 65% similar to the enzyme from Lactococcus lactis (gi|486725|).SMu1261 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001804
Family

Isocitrate/isopropylmalate dehydrogenase
G3DSA:3.40.718.10	$\"[3-344]T$	IDH_IMDH
PTHR11835	$\"[27-344]T$	IDH_IMDH_dimeric
PF00180	$\"[3-340]T$	Iso_dh
PS00470	$\"[235-254]T$	IDH_IMDH

InterPro
IPR004429
Family

3-isopropylmalate dehydrogenase
PTHR11835:SF13	$\"[27-344]T$	IPMDH
TIGR00169	$\"[3-344]T$	leuB

noIPR
unintegrated

unintegrated
PIRSF000107	$\"[2-344]T$	3-IPM_dh
SSF53659	$\"[1-344]T$	SSF53659

","BeTs to 12 clades of COG0473COG name: Isopropylmalate dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0473 is aMTkYqvcEBrh--------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001804 (Isocitrate and isopropylmalate dehydrogenases) with a combined E-value of 2.2e-51. IPB001804A 4-16 IPB001804B 126-140 IPB001804C 230-260 IPB001804D 272-299","Residues 92-141 are 62% similar to a (DEHYDROGENASE 3-ISOPROPYLMALATE) protein domain (PD243315) which is seen in LEU3_CANAL.Residues 161-343 are 70% similar to a (DEHYDROGENASE OXIDOREDUCTASE NAD ISOCITRATE) protein domain (PD186037) which is seen in LEU3_LACLA.Residues 3-55 are 73% similar to a (DEHYDROGENASE 3-ISOPROPYLMALATE) protein domain (PD307818) which is seen in LEU3_LACLA.Residues 90-140 are 68% similar to a (DEHYDROGENASE NAD OXIDOREDUCTASE ISOCITRATE) protein domain (PD289641) which is seen in LEU3_BACME.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 09:03:12 2002","Wed Mar 6 09:28:50 2002","Fri Oct 18 09:03:12 2002","Wed Mar 6 09:28:50 2002","Wed Mar 6 09:28:50 2002","Wed Mar 6 09:28:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1261 is paralogously related (blast p-value < 1e-3) to SMu0614, a predicted isocitrate dehydrogenase.","Wed Mar 6 09:28:50 2002","Wed Mar 6 09:28:50 2002","pdb|1XAC| Chimera Isopropylmalate Dehydrogenase Between Baci... 319 3e-088pdb|2AYQ|B Chain B, 3-Isopropylmalate Dehydrogenase From The Mo... 318 7e-088pdb|1IDM| 3-Isopropylmalate Dehydrogenase, Loop-Deleted Chim... 313 2e-086","SMU.1383c","","Residues 3 to 340 (E-value = 2.1e-186) place SMu1261 in the Iso_dh family which is described as Isocitrate/isopropylmalate dehydrogenase (PF00180)","Wed Mar 6 09:28:50 2002","","","","Godon,J.J., Chopin,M.C. and Ehrlich,S.D.Branched-chain amino acid biosynthesis genes in Lactococcus lactissubsp. lactisJ. Bacteriol. 174 (20), 6580-6589 (1992)PubMed: 1400210Delorme,C., Ehrlich,S.D. and Renault,P.Histidine biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6571-6579 (1992)PubMed: 1400209Godon,J.J., Delorme,C., Bardowski,J., Chopin,M.C., Ehrlich,S.D. and Renault,P.Gene inactivation in Lactococcus lactis: branched-chain amino acidbiosynthesisJ. Bacteriol. 175 (14), 4383-4390 (1993)PubMed: 8331070Delorme,C., Godon,J.J., Ehrlich,S.D. and Renault,P.Gene inactivation in Lactococcus lactis: histidine biosynthesisJ. Bacteriol. 175 (14), 4391-4399 (1993)PubMed: 7687248Goupil-Feuillerat,N., Cocaign-Bousquet,M., Godon,J.J., Ehrlich,S.D. and Renault,P.Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp. lactisJ. Bacteriol. 179 (20), 6285-6293 (1997)PubMed: 9335274","","Wed Mar 6 09:31:47 2002","1","","","SMU.1383c","" "SMu1262","1313512","1311947","1566","ATGCGTAAGGTTGAATTTCTTGACACAACGCTCCGTGATGGCGAACAAACACCGGGGGTTAATTTTTCGATTAAAGAAAAAGTAGCTATTGCCAAGCAATTGGAGAAGTGGGGAATCTCTGATATTGAAGCCGGTTTTCCAGCTGCTAGCCCTGACTCTTTTGAAGCTGTGAAGCAAATTGCAGCAGCGATGACAACGACTGCTGTATCAGGTCTGGCTCGTTCTGTGAAATCTGATATTGATGCCTGTTATGAGGCGCTTAAGGATGCCAAATTTCCACAATGTCATGTCTTTATTGCAACCAGTCCTATTCATCGTGAATTTAAGCTTAAAAAATCCAAAGAAGAAATTCTTGAAGTAATTAAGGAACATGTAACTTATGCGCGCTCAAAATTTGATGTGATTGAATTTTCACCAGAGGATGCCACACGTACAGAACTTGATTTCCTATTGCAGGTAGTGCAAACTGCTGTAGATGCTGGCGCTACTTATATTAATATCCCTGATACAGTTGGCTTTACCACGCCAGTAGAATTTGGCCATATTTTCAAGTATCTCATTGAAAATGTTAAATCTGACCGTGACATTATTTTCAGCCCTCATTGTCATGATGACTTAGGAATGGCAACCGCTAATACCCTCGCTGCCATTAAAAATGGTGCTGGACGTGTTGAAGGAACGGTTAATGGTATCGGAGAACGTGCTGGTAACGTAGCTCTTGAAGAAGTGGCCGTAGCTCTTAATATTCGTGAAGATTACTATGATGCGACCAGTGCTATCGTTCTTGATGAGACAGTGACCACTTCAGAAATGGTATCACGTTTCTCGGGTATTCCTATTCCTAAAAATAAAGCTGTTGTTGGTGGCAATGCTTTTTCACATGAATCCGGTATTCATCAAGATGGTTTTCTTAAGAATCCCCTCACTTATGAAATTATCACGCCTGAATTGGTTGGTGTTAAGAAAAGTTCCCTGCCGCTTGGGAAATTATCTGGCCGTCATGCCTTTATTGAAAAATTAAAAGAATTGAAGCTTGATTTTGAAGAAGGAGAGGTTGCACCTCTTTTTGCAAAATTTAAATCGTTGGCCGATAAAAAACACGATATCACAGATGCTGATATTAGAGCTTTGGTAGCAGGGACTAGTGTTGAAAATCCTGAAGGTTTCCACTTTAAGGACTTAAGGCTGACATCAAATGATGACGACACGATCACAGCACAAGTTATTATGGTCAATGAGGGTGAGGAAGAAGTAACTATCATTGCTAATGGTAAGGGTTCTGTTGAAGCTATTTTCAATGCTGTCGATAAATTCTTTAATCAAACTGTTAAGTTAGATAGTTATAATATCGAGGCTGTTACTGATGGTATTGATGCTCAGGCACGTGTGCTCGTTTCTGTGGAAAATATTGATACGGATACCATTTTCAATGCTTCTGGTCTTGACTTTGATGTTTTAAAAGCTAGTGCTATTGCTTATATCAATGCTAATACCTTTGTTCAAAAGGAAAATGCTGGTGAAATTGGTCACAAAGTTTCAGAACGTGATTATCCAAGTAATGACTAG","4.70","-26.18","56866","MRKVEFLDTTLRDGEQTPGVNFSIKEKVAIAKQLEKWGISDIEAGFPAASPDSFEAVKQIAAAMTTTAVSGLARSVKSDIDACYEALKDAKFPQCHVFIATSPIHREFKLKKSKEEILEVIKEHVTYARSKFDVIEFSPEDATRTELDFLLQVVQTAVDAGATYINIPDTVGFTTPVEFGHIFKYLIENVKSDRDIIFSPHCHDDLGMATANTLAAIKNGAGRVEGTVNGIGERAGNVALEEVAVALNIREDYYDATSAIVLDETVTTSEMVSRFSGIPIPKNKAVVGGNAFSHESGIHQDGFLKNPLTYEIITPELVGVKKSSLPLGKLSGRHAFIEKLKELKLDFEEGEVAPLFAKFKSLADKKHDITDADIRALVAGTSVENPEGFHFKDLRLTSNDDDTITAQVIMVNEGEEEVTIIANGKGSVEAIFNAVDKFFNQTVKLDSYNIEAVTDGIDAQARVLVSVENIDTDTIFNASGLDFDVLKASAIAYINANTFVQKENAGEIGHKVSERDYPSND","1311962","For other 'leu' genes see SMu1766 (leuRS); SMu1259 (leuD); SMu1260 (leuC) and SMu1261 (leuB). ","2-isopropylmalate synthase","Cytoplasm","Several matches in gapped BLAST to 2-isopropylmalate synthase: residues 1-516 are 66% similar to the enzyme from Lactococcus lactis (gi:2565151) and residues 1-497 are 56% similar to Listeria innocua (gi:16801160).SMu1262 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000891
Domain

Pyruvate carboxyltransferase
PF00682	$\"[12-278]T$	HMGL-like
PS50991	$\"[4-266]T$	PYR_CT

InterPro
IPR002034
Domain

Alpha-isopropylmalate/homocitrate synthase
PS00815	$\"[11-27]T$	AIPM_HOMOCIT_SYNTH_1
PS00816	$\"[198-211]T$	AIPM_HOMOCIT_SYNTH_2

InterPro
IPR005671
Family

Bacterial 2-isopropylmalate synthase
TIGR00973	$\"[3-497]T$	leuA_bact

InterPro
IPR013709
Domain

LeuA allosteric (dimerisation) domain
PF08502	$\"[368-500]T$	LeuA_dimer

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[2-263]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PTHR10277	$\"[103-508]T$	PTHR10277
PTHR10277:SF9	$\"[103-508]T$	PTHR10277:SF9
SSF110921	$\"[384-501]T$	SSF110921
SSF51569	$\"[1-290]T$	SSF51569

","BeTs to 11 clades of COG0119COG name: Isopropylmalate/homocitrate/citramalate synthasesFunctional Class: EThe phylogenetic pattern of COG0119 is AMTkYQVCEBRh---------Number of proteins in this genome belonging to this COG is 1","***** IPB002034 (Alpha-isopropylmalate and homocitrate synthase) with a combined E-value of 4.2e-104. IPB002034A 8-47 IPB002034B 140-176 IPB002034C 203-247 IPB002034D 283-311","Residues 369-490 are 53% similar to a (SYNTHASE 2-ISOPROPYLMALATE LYASE) protein domain (PD002462) which is seen in LEU1_LACLA.Residues 273-360 are 67% similar to a (SYNTHASE LYASE 2-ISOPROPYLMALATE COMPLETE PROTEOME) protein domain (PD000608) which is seen in LEU1_LACLA.Residues 140-333 are 28% similar to a (SYNTHASE 2-PHOSPHINOMETHYLMALIC ACID) protein domain (PD240720) which is seen in Q9LCB4_STRHY.Residues 165-250 are 34% similar to a (PROTEOME LEUA-3 COMPLETE) protein domain (PD343901) which is seen in Q9UZ04_PYRAB.Residues 165-236 are 54% similar to a (SYNTHASE 2-ISOPROPYLMALATE LYASE) protein domain (PD037472) which is seen in LU1B_LYCPN.Residues 150-242 are 58% similar to a (LYASE SYNTHASE HOMOCITRATE FIXATION) protein domain (PD344479) which is seen in LEU1_THEMA.Residues 8-50 are 83% similar to a (SYNTHASE LYASE 2-ISOPROPYLMALATE HOMOCITRATE) protein domain (PD001803) which is seen in LEU1_LACLA.Residues 284-378 are 54% similar to a (SYNTHASE LYASE 2-ISOPROPYLMALATE) protein domain (PD246011) which is seen in LEU1_BACSU.Residues 84-163 are 50% similar to a (SYNTHASE 2-ISOPROPYLMALATE LYASE B) protein domain (PD400614) which is seen in Q9C550_ARATH.Residues 69-248 are 75% similar to a (LYASE SYNTHASE 2-ISOPROPYLMALATE COMPLETE) protein domain (PD327958) which is seen in LEU1_LACLA.Residues 51-111 are 58% similar to a (SYNTHASE 2-ISOPROPYLMALATE PROTEOME) protein domain (PD399814) which is seen in LEU1_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 24 11:23:05 2005","Wed Mar 6 09:38:11 2002","Tue May 24 11:23:05 2005","Wed Mar 6 09:38:11 2002","Wed Mar 6 09:38:11 2002","Wed Mar 6 09:38:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1262 is paralogously related (blast p-value < 1e-3) to SMu0933, a predicted pyruvate carboxylase/oxaloacetate decarboxylase, alpha subunit.","Wed Mar 6 09:38:11 2002","","No significant hits to the NCBI PDB database.","SMU.1384c","","Residues 12 to 278 (E-value = 2.1e-127) place SMu1262 in the HMGL-like family which is described as HMGL-like (PF00682)","Wed Mar 6 09:38:11 2002","","","","Godon,J.J., Chopin,M.C. and Ehrlich,S.D.Branched-chain amino acid biosynthesis genes in Lactococcus lactissubsp. lactisJ. Bacteriol. 174 (20), 6580-6589 (1992)PubMed: 1400210Delorme,C., Ehrlich,S.D. and Renault,P.Histidine biosynthesis genes in Lactococcus lactis subsp. lactisJ. Bacteriol. 174 (20), 6571-6579 (1992)PubMed: 1400209Godon,J.J., Delorme,C., Bardowski,J., Chopin,M.C., Ehrlich,S.D. and Renault,P.Gene inactivation in Lactococcus lactis: branched-chain amino acidbiosynthesisJ. Bacteriol. 175 (14), 4383-4390 (1993)PubMed: 8331070Delorme,C., Godon,J.J., Ehrlich,S.D. and Renault,P.Gene inactivation in Lactococcus lactis: histidine biosynthesisJ. Bacteriol. 175 (14), 4391-4399 (1993)PubMed: 7687248Goupil-Feuillerat,N., Cocaign-Bousquet,M., Godon,J.J., Ehrlich,S.D. and Renault,P.Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp. lactisJ. Bacteriol. 179 (20), 6285-6293 (1997)PubMed: 9335274","","Wed Mar 6 09:38:11 2002","1","","","SMU.1384c","" "SMu1263","1314467","1313838","630","ATGCGAAAAAAACCGATTATCATTGGTGTAACAGGCGGTTCTGGTAGTGGAAAAACCAGTGTCTCACGGGCTATTTTGGCCAACTTCCCCAATGCTAAAATTGCTATGATTGAACACGATTCTTACTATAAGGATCAGAGTCATCTGACTTTTGAAGAGCGTGTAACAACTAATTATGATCACCCTTTGGCTTTTGAAACAGACTTACTGATCAATCATTTGAAAGAGTTAATTGCTGATCGTCCGGTAGATATTCCCATTTATGACTACACACAGCATACACGCAGTGAAAAGAGTTATCGTCAAGAGCCTCAAGATGTTTTTATTGTTGAAGGCATTCTTGTCTTAGAAGATCAGCGTTTGCGTGACCTGATGGATATTAAATTATTTGTTGATACCGATGATGACATTCGTATTATTCGCCGAATTAAACGTGATATGCAAGAGCGCGGTCGTAGTTTAGATAGCATTATTGAGCAGTATACAAGAGTTGTTAAACCTATGTACCATCAATTTATTGAACCAACCAAGCGCTATGCTGATATTGTTGTTCCAGAAGGTGTCAGCAATCTCGTTGCCATTGATTTAATCAATACCAAAGTGGCCAGTATTTTAAACGAAACACATTAA","6.20","-3.31","24169","MRKKPIIIGVTGGSGSGKTSVSRAILANFPNAKIAMIEHDSYYKDQSHLTFEERVTTNYDHPLAFETDLLINHLKELIADRPVDIPIYDYTQHTRSEKSYRQEPQDVFIVEGILVLEDQRLRDLMDIKLFVDTDDDIRIIRRIKRDMQERGRSLDSIIEQYTRVVKPMYHQFIEPTKRYADIVVPEGVSNLVAIDLINTKVASILNETH","1313853","","uridine kinase","Cytoplasm","Several matches in gapped BLAST to uridine kinase: residues 1-207 are 70% similar to the enzyme in S.pyogenes (gi|15675300|) and are 69% similar to the protein from S.pneumoniae (gi|15901071|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0826 (1e-85).","

InterPro
IPR000764
Family

Uridine kinase
PR00988	$\"[5-22]T$ $\"[35-46]T$ $\"[80-95]T$ $\"[136-146]T$ $\"[150-161]T$ $\"[172-185]T$	URIDINKINASE
PTHR10285:SF6	$\"[13-207]T$	Uridine_kin
TIGR00235	$\"[1-206]T$	udk

InterPro
IPR006083
Family

Phosphoribulokinase/uridine kinase
PF00485	$\"[7-193]T$	PRK

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-207]T$	G3DSA:3.40.50.300
PTHR10285	$\"[13-207]T$	PTHR10285
SSF52540	$\"[4-207]T$	SSF52540

","BeTs to 8 clades of COG0572COG name: Uridine kinaseFunctional Class: FThe phylogenetic pattern of COG0572 is ----Y-vceb-h--gpol-n-Number of proteins in this genome belonging to this COG is 1","***** PR00988 (Uridine kinase signature) with a combined E-value of 2.9e-49. PR00988A 5-22 PR00988B 35-46 PR00988C 80-95 PR00988D 136-146 PR00988E 150-161 PR00988F 172-185***** IPB001324 (Phosphoribulokinase family) with a combined E-value of 1.7e-33. IPB001324A 4-25 IPB001324C 103-114 IPB001324D 129-179","Residues 127-206 are 61% similar to a (KINASE URIDINE COMPLETE MONOPHOSPHOKINASE) protein domain (PD003826) which is seen in Q9CF21_LACLA.Residues 7-126 are 68% similar to a (KINASE URIDINE TRANSFERASE ATP-BINDING) protein domain (PD003288) which is seen in Q9CF21_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 09:50:58 2002","Wed Mar 6 09:46:59 2002","Fri Oct 18 09:02:08 2002","Wed Mar 6 09:46:59 2002","Wed Mar 6 09:46:59 2002","Wed Mar 6 09:46:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1263 is paralogously related (blast p-value < 1e-3) to SMu1029, a predicted pantothenate kinase.","Wed Mar 6 09:46:59 2002","","No significant hits to the NCBI PDB database.","SMU.1386c","","Residues 7 to 193 (E-value = 4.2e-52) place SMu1263 in the PRK family which is described as Phosphoribulokinase / Uridine kinase family (PF00485)","Wed Mar 6 09:46:59 2002","","","","Neuhard,J. and Tarpo,L.Location of the udk gene on the physical map of Escherichia coliJ. Bacteriol. 175 (17), 5742-5743 (1993)PubMed: 8366067","","Wed Mar 6 09:53:07 2002","1","","","SMU.1386c","329" "SMu1264","1314686","1315666","981","ATGCTCAAACTTGGTATTATTGGGACAGGATCCATTTCGCATCAGTTTATTGAAGCAGCTCAGCTCAGCCAGCACTATCAATTAACAGCGGTTTATTCACGAAAATTAGAAACAGCAGAAGCTTTTTCTGCACGTTATCAAAATATTGCCTGCTATGATATGCTAGATGACTTTTTTAACGATGCTTTTGATGTTCTTTATATTGCCAGCCCAAATGCCCTTCATTTTGAACACGCCAAATTAGCATTAGAAGCTGGAAAGCATATTATTGTTGAAAAGCCGGCTTTCTCAACTCCAGAGGAGTTAAGCAATATTATCCACTCGGCAGAAAAAAAACAACTGTTCTTTTTTGAAGCTGCTCGTAATTATCATGAAGAATCTCTCCTTCTTATTAAGGAATTCCTATCCCACAAAACAGTTATCGGGGCTGACTTTTCCTATGCTAAGTATTCTTCAAAAATGAAGGATTTACTGGCAGGCAAGCTGCCTAATGTTTTTTCAGATAAGTTTTCAGGAGGAGCTTTAGTTGATTTGGGAATTTATCCTATTTACGCTGCTATCAAACTTTTTGGAAAGCCTAAAAGTGTCAACTACACAGCGACACAATTGGAAAACACCATTGATTTGAACGGCAATGGCAATCTGATTTATCCTGATTTTCATGTTTCCATTAGGGCAGGAAAGAATTACAACACCTTAGAATACGCTGAAATTTATACCAGTGAGGGAACTCTCCGACTGAATCATATTCAAGGAATCAGCTCTGCTATTTTCCAAAAACATGATGGCAGCCGCGAAAAATTAGCTCTTCCTGACATTGAACACCTCATGTTGGAAGAAGCAAAGCACTTTGCTGAAATGATGAACAATAAAAATGAGGTCATTTACCAGACTTGGTTAGAGGATGCTAAAACGGCTAGTCAAATTCTCTATCAGATGCGTCAAAGTGCCGGTATTGTATTTGAGGCAGACAAAAAATGA","6.30","-4.90","36772","MLKLGIIGTGSISHQFIEAAQLSQHYQLTAVYSRKLETAEAFSARYQNIACYDMLDDFFNDAFDVLYIASPNALHFEHAKLALEAGKHIIVEKPAFSTPEELSNIIHSAEKKQLFFFEAARNYHEESLLLIKEFLSHKTVIGADFSYAKYSSKMKDLLAGKLPNVFSDKFSGGALVDLGIYPIYAAIKLFGKPKSVNYTATQLENTIDLNGNGNLIYPDFHVSIRAGKNYNTLEYAEIYTSEGTLRLNHIQGISSAIFQKHDGSREKLALPDIEHLMLEEAKHFAEMMNNKNEVIYQTWLEDAKTASQILYQMRQSAGIVFEADKK","1315675","","oxidoreductase","Cytoplasm","Limited matches in gapped BLAST to oxidoreductase:residues 1-325 are 59% similar to the enzyme from S.pneumoniae (gi|15903378|) and residues 1-326 are 51% similar to the enzyme from Lactococcus lactis (gi|15673643|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1542 (2e-29).","

InterPro
IPR000683
Domain

Oxidoreductase, N-terminal
PF01408	$\"[2-120]T$	GFO_IDH_MocA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-136]T$	G3DSA:3.40.50.720
PTHR22604	$\"[52-219]T$	PTHR22604
PTHR22604:SF15	$\"[52-219]T$	PTHR22604:SF15
SSF51735	$\"[1-173]T$	SSF51735
SSF55347	$\"[163-279]T$	SSF55347

","BeTs to 8 clades of COG0673COG name: Predicted dehydrogenases and related proteinsFunctional Class: RThe phylogenetic pattern of COG0673 is --tKYqVCEB--uj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 71-186 are 63% similar to a (OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD001155) which is seen in Q9CF20_LACLA.Residues 71-197 are 28% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD213870) which is seen in Q9HK27_THEAC.Residues 2-157 are 23% similar to a (PROTEOME COMPLETE CJ0504C) protein domain (PD358074) which is seen in Q9PI07_CAMJE.Residues 1-70 are 54% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD406787) which is seen in Q9CF20_LACLA.Residues 190-274 are 43% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD407148) which is seen in Q9CF20_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 09:01:30 2002","Wed Mar 6 09:58:19 2002","Fri Oct 18 09:01:30 2002","Wed Mar 6 09:58:19 2002","","Wed Mar 6 09:58:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1264 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 09:58:19 2002","","No significant hits to the NCBI PDB database.","SMU.1387","","Residues 2 to 120 (E-value = 1.4e-29) place SMu1264 in the GFO_IDH_MocA family which is described as Oxidoreductase family, NAD-binding Rossmann fold (PF01408)","Wed Mar 6 09:58:19 2002","24379792","","","","","","1","","","SMU.1387","" "SMu1265","1315663","1316745","1083","ATGAAAACACAATTTCCAAGCGTTTGGCAAGATAAACTCAGCCAAAAACATTTTTCAGCATTTACGACCATTCAAGAAGCTGCTTTTGACCCTATTAAAAATGGTAAGAGTCTTCTTGGTATCAGCCCCACTGGTAGTGGTAAGACCTTAGCCTATCTTTGGCCTAGTTTACTCACTCTCACACCTAAAAAAGCTCAACAATTGCTCATTCTAGCTCCTAATACCGAGTTAGCTGGACAGATTTTTGAAGTTGCCAAGGAATGGGCTCAACCTCTTAATTTAACAGCCCAGCTTTTTTTATCAGGTTCCAGTCAAAAACGACAAATTGAACGTTTAAAAAAAGGACCAGAAATTATCATTGGCACACCTGGACGTGTTTTTGACCTTGTGAAACTCAAAAAGATTAAGATGATGAACGTTAATACAATTGTTCTAGATGAATTTGATGACTTACTTGGTAAATCTCAAATTCACTTTGTTAAAAATATTGTGAAACGTGTTCCTCGTGACCATCAGATGATTTATATGAGTGCAACAAATAGCATTGATAGAACATTTTTGGCTGATGATACCCTTGAGATTGACTTATCAAAACAAACGGTAGACACCATTTCTCATTATTATATCACTGTTGCTAAGCGTGAACGCGGAGAATTGCTGCGTAAATTTTCTAACATTCCTAACTTTAGGGGACTTGTTTTCTTTAACAGGCTGTCAGACTTAGGAGCCAATGAAGAGCGTCTACAATTTAGCGGTGCTTCTGCTGTTTCACTTGCCAGTGATGTTAATATTAAATTCCGCAAAGTCATTTTAGAAAAATTCAAAAATCATGAACTCTCTCTATTGCTGGCAACAGATTTAGTAGCGCGCGGCATTGATATTGAGCTTCTCGAAACAGTTATCAACTTTGATTTACCAAGAGATAAAGATGCATACAATCACCGTGCCGGACGAACAGGACGCATGGGAAAAAATGGTATTGTTGTTACCTTTATTAGTCATCCTGAAGAACTTAAAAAACTGAAAAAATTTGCACACGTTTCAGAAGTCTATCTTAAAAATCAGATTTTACATAAAAAATGA","10.50","17.18","40788","MKTQFPSVWQDKLSQKHFSAFTTIQEAAFDPIKNGKSLLGISPTGSGKTLAYLWPSLLTLTPKKAQQLLILAPNTELAGQIFEVAKEWAQPLNLTAQLFLSGSSQKRQIERLKKGPEIIIGTPGRVFDLVKLKKIKMMNVNTIVLDEFDDLLGKSQIHFVKNIVKRVPRDHQMIYMSATNSIDRTFLADDTLEIDLSKQTVDTISHYYITVAKRERGELLRKFSNIPNFRGLVFFNRLSDLGANEERLQFSGASAVSLASDVNIKFRKVILEKFKNHELSLLLATDLVARGIDIELLETVINFDLPRDKDAYNHRAGRTGRMGKNGIVVTFISHPEELKKLKKFAHVSEVYLKNQILHKK","1316754","For other 'dea' genes see SMu0557 (deaD).For other 'rhe' genes see SMu0557 (rheA) and SMu0415 (rheB).","ATP-dependent RNA helicase, DEAD/DEAH family","Cytoplasm, Membrane","Numerous matches in gapped BLAST to ATP-dependent RNA helicases. Residues 1-358 are 73% similar to gi15675301 from S.pyogenes and 65% similar to gi15901333 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0825 (1e-154).","

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[247-323]T$	Helicase_C
SM00490	$\"[242-323]T$	HELICc
PS51194	$\"[218-360]T$	HELICASE_CTER

InterPro
IPR011545
Domain

DEAD/DEAH box helicase, N-terminal
PF00270	$\"[22-187]T$	DEAD

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[17-207]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[29-198]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[5-193]T$ $\"[199-347]T$	G3DSA:3.40.50.300
PTHR10967	$\"[4-345]T$	PTHR10967
PTHR10967:SF8	$\"[4-345]T$	PTHR10967:SF8

","BeTs to 13 clades of COG0513COG name: Superfamily II DNA and RNA helicasesFunctional Class: L,K,JThe phylogenetic pattern of COG0513 is amTkYq-CEBRHujGPol--xNumber of proteins in this genome belonging to this COG is 3","***** IPB000629 (ATP-dependent helicase, DEAD-box) with a combined E-value of 1.6e-49. IPB000629A 17-60 IPB000629B 69-81 IPB000629C 117-128 IPB000629D 140-163 IPB000629E 285-326","Residues 290-333 are 56% similar to a (HELICASE ATP-BINDING ATP-DEPENDENT RNA DNA PROTEOME) protein domain (PD007610) which is seen in DB80_DROME.Residues 68-174 are 31% similar to a (HELICASE ATP-BINDING RNA ATP-DEPENDENT) protein domain (PD324530) which is seen in Q9SIB5_ARATH.Residues 106-149 are 68% similar to a (HELICASE ATP-BINDING RNA-BINDING ATP-DEPENDENT FACTOR) protein domain (PD000276) which is seen in O34750_BACSU.Residues 69-149 are 34% similar to a (HELICASE ATP-BINDING RNA RNA-BINDING) protein domain (PD100069) which is seen in Q9SEV8_GUITH.Residues 290-336 are 55% similar to a (HELICASE ATP-BINDING RNA-BINDING ATP-DEPENDENT FACTOR) protein domain (PD035460) which is seen in Q9TY94_PLAFA.Residues 4-157 are 31% similar to a (HELICASE ATP-BINDING RNA-BINDING MG308) protein domain (PD035480) which is seen in Y308_MYCGE.Residues 16-113 are 34% similar to a (HELICASE III ATP-BINDING RNA) protein domain (PD243987) which is seen in YOQ2_CAEEL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 11:04:18 2006","Mon Sep 11 11:04:18 2006","Mon Sep 11 11:04:18 2006","Wed Mar 6 10:04:04 2002","Wed Mar 6 10:04:04 2002","Wed Mar 6 10:04:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1265 is paralogously related (blast p-value < 1e-3) to SMu0557 and SMu0415, both predicted ATP-dependent RNA helicases and SMu0434, a predicted primosomal replication factor Y (primosomal protein N').","Mon Sep 11 11:04:18 2006","Mon Sep 11 11:04:18 2006","pdb1FUUA Chain A, Yeast Initiation Factor 4a >gi11513345pdb... 148 1e-036pdb1FUKA Chain A, Crystal Structure Of The Carboxy Terminal D... 82 8e-017pdb1QDEA Chain A, Crystal Structure Of The Atpase Domain Of T... 82 1e-016","SMU.1388","","Residues 11 to 212 (E-value = 5.5e-47) place SMu1265 in the DEAD family which is described as DEAD/DEAH box helicase (PF00270)Residues 247 to 323 (E-value = 1.6e-22) place SMu1265 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)","Mon Sep 11 11:04:18 2006","24379793","","","","","","1","","","SMU.1388","328" "SMu1266","1318578","1316938","1641","ATGGTTACACGCCAACATTTTTCAGAAGATTCAATGCGTAAAAACAATTCTTATTTTTCAGCATTAAAAGCTACTATTGAAACTGCTTTTTACGAAAATCATGTGGTGCCTTTGAAGGAGTTGGCAGAAGCTTATCGGTTAGCTGCAAAATCTCCTAACACTATTGTTTTAGATACACCCGTTGCTCATGCTGAGGATTTAGGTCTTCCGAAAGATGCAAAAATTTTATTGGAAAATTCAGGCGGAATTGTTGGACGTACTGCCAAGGCTCGTCGAATTTTTGGACAGGATAGTAAAGAAGACGCAAAAATTCTTCAAATTATTCGTGAAGCCATTTTTCAGGCTAGGCATCGTACTTTTTATCGCGCAGATGCAGTTGTAGGGCTTGATGAAGCTTTTATGTTACGTGCTCATCTAATGGTACCACAAGATGATATTAATAATCTCTACTCTTGGCTTAATAATTTTCAAGTTCTTAATGATACTTATCGTGAGCGTTTAAAGAAATCAAAACGCTATGAAGAGACTGATATTTATATTTTTTCTGATCCAGAGTGGAGTCATCCTGATTATCCAGATGGTTTGGTTTATTTTGATACCAATCACAATTGTGCTGCTATTCTGGGACTCCATTATTTTGGAGAATTAAAAAAAGCAACCTTGACTTTGGCTTGGGGAACAGCTAATCGTAATAAATATGTTGCCTGTCATGGTGGTTTGAAAATTTTTGAAAAAGAAGGACAAAAACCTTATGTGGCCTCCTTTTTTGGCCTATCTGGTTCTGGCAAGTCAACTCTCACACATGCTAAACATAATGGGAAATATCGGATAGATGTCTTGCATGATGACGCTTTTGTTATTTCTGAAGAGGACGGCTCAACAATTGCCCTAGAGCCTGCTTATTTTGATAAGACAAATGACTACCCAGCTGGTCATCGCGAACAGAAGTATTTTGTAGCGGTTCAAAATTGCGGTGCGGCTTTGGATAAGGAAGGGCATCTTCGCCTTGTTACTGAGGATATCAGAAATGGAAATGGTCGAACCATTAAGTCTCGTTTTTCAACACCTAACCGTGTGGATCGTATTAATCACCCTATTCAGTCCATTTTTTGGATAATGAAGGATGATTCTTTACCACCTCTTATTAGGGTTACCGACCCTATTATGGCTTCAATTATGGGGTGTACTTTGGTTACGACGCGATCAACGGCTGAAAATACGACTGACAGTTTAGATGCGTTAATTATTGAACCTTATGCTAATCCTTTCCGTGTCTATCCATTGGTGGAAGATTATATTAAGTTTCAACATTTATTTGAATCAGGAGTAAACTGTTATATTATCAATACAGGTTCTTATTTGGGACAAGATATTCCTAAAGAGACTACGTTGGATGTTATTGAACAAGTGGTTGATGGTACTGCAAAATTTGAGCCTTTTGGTTCCGTCAAAGGCTTTGAATACCTCTCTTCTTCTCACTATAAGATTCCTAATTTTGATAAGGCTTATGTCAAAATTATCCGCCAACGGATGAAAATCCGATTGCAATATTTGGAAGCTTTTAATCGAAAAAATCCTAAATTGTCTTTGCCTGATGAAGCAATCTCACATTTGAAAGATGTCTTGGCTAATTTAGGTTAG","7.10","1.14","61963","MVTRQHFSEDSMRKNNSYFSALKATIETAFYENHVVPLKELAEAYRLAAKSPNTIVLDTPVAHAEDLGLPKDAKILLENSGGIVGRTAKARRIFGQDSKEDAKILQIIREAIFQARHRTFYRADAVVGLDEAFMLRAHLMVPQDDINNLYSWLNNFQVLNDTYRERLKKSKRYEETDIYIFSDPEWSHPDYPDGLVYFDTNHNCAAILGLHYFGELKKATLTLAWGTANRNKYVACHGGLKIFEKEGQKPYVASFFGLSGSGKSTLTHAKHNGKYRIDVLHDDAFVISEEDGSTIALEPAYFDKTNDYPAGHREQKYFVAVQNCGAALDKEGHLRLVTEDIRNGNGRTIKSRFSTPNRVDRINHPIQSIFWIMKDDSLPPLIRVTDPIMASIMGCTLVTTRSTAENTTDSLDALIIEPYANPFRVYPLVEDYIKFQHLFESGVNCYIINTGSYLGQDIPKETTLDVIEQVVDGTAKFEPFGSVKGFEYLSSSHYKIPNFDKAYVKIIRQRMKIRLQYLEAFNRKNPKLSLPDEAISHLKDVLANLG","1316953","","phosphoenolpyruvate carboxykinase (ATP)","Cytoplasm","Limited weak matches in gapped BLAST to phosphoenolpyruvate carboxykinase (ATP). Residues 175-480 are 24% similar to gi|15792261| from Campylobacter jejuni and residues 72-480 are 22% similar to gi|3914406| from Kluyveromyces lactis.SMu1266 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF53795	$\"[237-517]T$	SSF53795
SSF68923	$\"[52-232]T$	SSF68923

","BeTs to 3 clades of COG1866COG name: Phosphoenolpyruvate carboxykinaseFunctional Class: CThe phylogenetic pattern of COG1866 is ----y---eb-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB001272 (Phosphoenolpyruvate carboxykinase (ATP)) with a combined E-value of 2.2e-08. IPB001272A 70-104 IPB001272C 206-229 IPB001272D 250-291 IPB001272G 439-455","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 10:11:04 2002","Wed Mar 6 10:08:13 2002","Fri Oct 18 08:58:50 2002","Wed Mar 6 10:08:13 2002","Wed Mar 6 10:08:13 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1266 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 10:11:04 2002","","No significant hits to the NCBI PDB database.","SMU.1389c","","No significant hits to the Pfam 11.0 database","Wed Mar 6 10:08:13 2002","","","","Kitamoto,H.K., Ohmomo,S. and Iimura,Y.Isolation and nucleotide sequence of the gene encodingphosphoenolpyruvate carboxykinase from Kluyveromyces lactisYeast 14 (10), 963-967 (1998)PubMed: 9717242","","Wed Mar 6 10:12:31 2002","1","","","SMU.1389c","" "SMu1267","1318897","1319553","657","ATGTCCAAAACACAAGCTTTCAGAAGTCTGATTGCCCTTTTAGGTCTTATCGGCGTCAGCATTCAAATCAAACAATCCGGTTGGGGAATGCTCCTTTATTATACAACTCTTTCAAATGTCATTGTCTGTAGTTTTCTGACCTATCTTGTCATTAAAGAAAAGCGTAACGGTTCTATCAATTCCAATCCTAAGCTCTTACGCCTCAAGGGTGGTGTAACCATGACAATTATGATTACTTTTATGGTCTATCATTTTTTATTAGCACCTAAGGTAAGATCTTACGATTACTATACTATTCGCAATTTCCTTGTTCATTACATTGTTCCTCTTAGTACTATTTTTGATACCTTGATTTGTGATCGTCGCAAAATATATCGTTGGTTTGACCCTATTATCTGGACCTGTCTTCCCTTACTTTACTTTGGTTTTGCGCTTATCAATGGACTTCTCTTAAAATGGCCAATCCCTGGTACTGCTGATAGTCCCTTCCCATATTTTTTCATTAATATGAATAAATACGGAGCACAGCAAGTGTTAATCAATGCCTTGGTTATTGCACTACTGTACTTACTCTTTGGCTATATTCTATTGGGAATCAAGCAAATGATTGGTCAAAAGAGGCAAGTGACTGACAATTCCTCTTTGAACATGTCCTGA","10.70","14.31","25037","MSKTQAFRSLIALLGLIGVSIQIKQSGWGMLLYYTTLSNVIVCSFLTYLVIKEKRNGSINSNPKLLRLKGGVTMTIMITFMVYHFLLAPKVRSYDYYTIRNFLVHYIVPLSTIFDTLICDRRKIYRWFDPIIWTCLPLLYFGFALINGLLLKWPIPGTADSPFPYFFINMNKYGAQQVLINALVIALLYLLFGYILLGIKQMIGQKRQVTDNSSLNMS","1319562","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins :residues 8-172 are 53% similar to gi|15901441| from S.pneumoniae.Residues 7-180 are 24% similar to gi|16127657| from Caulobacter crescentus.SMu1267 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[31-51]?$ $\"[70-88]?$ $\"[131-151]?$ $\"[178-198]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-185 are 26% similar to a (REGULATOR MEMBRANE INTEGRAL) protein domain (PD315712) which is seen in Q9X936_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 10:15:56 2002","Wed Mar 6 10:15:56 2002","Wed Mar 6 10:15:56 2002","Wed Mar 6 10:15:56 2002","","Wed Mar 6 10:15:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1267 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 10:15:56 2002","","No significant hits to the NCBI PDB database.","SMU.1390","","No significant hits to the Pfam 11.0 database","Wed Mar 6 10:15:56 2002","24379795","","","","","","1","","","SMU.1390","" "SMu1268","1320226","1319618","609","ATGCCAAGACGTCGTGCTAGCCGTAGGAAATCAAAAAAGAAGGCTGTTTTTAGTATTTTATTAACGGGTATTACTCTTATTATTATTGGTTTAGCCGTTTATTTTATTTCAGCCTATTTTACAAATACAAAGAAAACAGCAAATAAAGAAAAGACACAGACACATATTGTTAATCCTAAGAAGGATCCAGAAGAAAAGAAGGAAGCAGATTCCGCTTCAAAAGCAACATCTAAGTTTGATTTAACAACTATTGCTACAGGAGATTACAGTTCAGCTGCGGGAACTTGGCAAAATGAACTGGGCGATCAGCTTAAGTTTAATGCAAGTGGTCTTGAAAGTGCCACTATCCAAAATGCAACGGATTTCACCATTTCATCTGGACAGGCAACAAATGATGGCCTGTATCAAGCAACTTTGACTTCAGCAGATAGTACAGTGGTTTATAATTTGCTCTTTGTTAAAGGCGGGACAGCAATACCTGAAAATTACTTTACGACAGGTTATAGTGATACCTCAGATACTTCTCGTGATCGTCTTTATATCAGCTCGCAAACGACTTTTGGCAGCGATGATTTCAGCAAGGGAATTTTCTATAAATCTGAAAATTAA","9.90","4.23","22090","MPRRRASRRKSKKKAVFSILLTGITLIIIGLAVYFISAYFTNTKKTANKEKTQTHIVNPKKDPEEKKEADSASKATSKFDLTTIATGDYSSAAGTWQNELGDQLKFNASGLESATIQNATDFTISSGQATNDGLYQATLTSADSTVVYNLLFVKGGTAIPENYFTTGYSDTSDTSRDRLYISSQTTFGSDDFSKGIFYKSEN","1319633","","hypothetical protein","Extracellular, Membrane","No significant hits in gapped BLAST found. SMu1268 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[15-35]?$	transmembrane_regions

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[60-148]T$	Acetyltransf_1
PS51186	$\"[1-158]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[1-155]T$	G3DSA:3.40.630.30
PTHR10545	$\"[89-146]T$	PTHR10545
SSF55729	$\"[1-158]T$	SSF55729

","BeTs to 8 clades of COG0454COG name: Predicted acetyltransferasesFunctional Class: RThe phylogenetic pattern of COG0454 is AmTKYqVCEBR-uj----in-Number of proteins in this genome belonging to this COG is 8","No significant hits to the Blocks database.","Residues 93-146 are 62% similar to a (COMPLETE PROTEOME TRANSFERASE) protein domain (PD350597) which is seen in Q9EVV9_STRTR.Residues 3-92 are 47% similar to a (DOMAIN OF UNKNO N) protein domain (PD392586) which is seen in Q9EVV9_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 22 08:08:28 2002","Mon Jul 10 14:19:28 2006","Mon Jul 10 14:19:28 2006","Wed Mar 6 10:30:28 2002","","Wed Mar 6 10:30:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1269 is paralogously related (blast p-value < 1e-3) to SMu1373, a predicted acetyltransferase, GNAT family.","Wed Mar 6 10:30:28 2002","","No significant hits to the NCBI PDB database.","SMU.1392c","","Residues 60 to 148 (E-value = 1.3e-17) place SMu1269 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Wed Mar 6 10:30:28 2002","24379797","","","","","","1","","","SMU.1392c","795" "SMu1270","1321688","1320861","828","ATGGCAGCACTTAATAAAGAAATGGTTAATACTTTGCTTGGTCCGATTTATACTTGTCATAGAGAGGGTAATCCCTGTTTTGTCTTCTTAAGCGGTGCTGGTTTTTTCAGTACGGCTGACAATTTTGCTAATATTATTGACAAATTGCCTGATAGCATTGGCATATTAACCATAGATGCCCCCAATAGTGGCTACAGTCCTGTTAGCAATCAAGCGAATGTTGGACTCAGAGATTGGGTCAATGCTATTTTAATGATTTTTGAACACTTTAAATTTCAATCGTATCTTTTATGTGTTCATAGCATTGGCGGTTTTGCAGCTTTGCAAATAATGAATCAATCATCAAAGGCTTGTTTAGGCTTTATTGGGCTGGAACCAACGACTGTTATGATTTATCGTGCGGGTTTTTCTTCGGATCTTTATCCTCAATTGGCTCTGCGGCGGCAAAAATTAAAAACAGCAGCTGATAGGCTTAACTACCTTAAAGATCTCAGTCGTTCTCATTTTTCTTCTCAACAGTTTAAGCAGTTGTGGCGGGGCTATGATTATTGTCAGAGACAATTAAATGATGTTCAGTCTTTGCCTGATTTTAAAATAAGGCTTGCTTTAGGAGAAGAGGATTTTAAAACTGGTATTTCTGAAAAAATTCCTTCTATTGTTTTTTCGGAGTCTTTTCGTGAGAAAGAATATTTAGAATCTGAATACCTAAATAAGCATACACAGACAAAACTTATTCTCTGTGGTCAGCATCATTATTTGCACTGGTCAGAAACAAATTCCATTTTAGAAAAAGTTGAACAACTGCTGTCAAATCATGAAAAGTTGTAA","7.20","0.88","31307","MAALNKEMVNTLLGPIYTCHREGNPCFVFLSGAGFFSTADNFANIIDKLPDSIGILTIDAPNSGYSPVSNQANVGLRDWVNAILMIFEHFKFQSYLLCVHSIGGFAALQIMNQSSKACLGFIGLEPTTVMIYRAGFSSDLYPQLALRRQKLKTAADRLNYLKDLSRSHFSSQQFKQLWRGYDYCQRQLNDVQSLPDFKIRLALGEEDFKTGISEKIPSIVFSESFREKEYLESEYLNKHTQTKLILCGQHHYLHWSETNSILEKVEQLLSNHEKL","1320876","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypothetical proteins:residues 9-269 are 35% similar to S.pneumoniae (gi|15900671|).Residues 160-268 are 37% similar to S.pneumoniae (gi|15902729|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0681 (1e-06).","

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[17-130]T$	G3DSA:3.40.50.1820
SSF53474	$\"[1-269]T$	SSF53474

InterPro
IPR000178
Family

Initiation factor 2
PD186100	$\"[168-232]T$	IF2

InterPro
IPR000640
Domain

Translation elongation factor EFG/EF2, C-terminal
G3DSA:3.30.70.240	$\"[410-500]T$	Transl_elong_EFG/EF2_C
PF00679	$\"[407-496]T$	EFG_C

InterPro
IPR000795
Domain

Protein synthesis factor, GTP-binding
PR00315	$\"[15-28]T$ $\"[58-66]T$ $\"[83-93]T$ $\"[99-110]T$ $\"[135-144]T$	ELONGATNFCT
PF00009	$\"[11-193]T$	GTP_EFTU
PS00301	$\"[51-66]T$	EFACTOR_GTP

InterPro
IPR004161
Domain

Translation elongation factor EFTu/EF1A, domain 2
PF03144	$\"[214-284]T$	GTP_EFTU_D2

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[11-187]T$	small_GTP

InterPro
IPR006297
Family

GTP-binding protein LepA
TIGR01393	$\"[11-605]T$	lepA

InterPro
IPR009000
Domain

Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447	$\"[192-291]T$	Translat_factor

InterPro
IPR009022
Domain

Elongation factor G, III and V
SSF54980	$\"[299-379]T$ $\"[410-533]T$	EFG_III_V

InterPro
IPR013842
Domain

GTP-binding protein LepA, C-terminal
PF06421	$\"[497-605]T$	LepA_C

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.870	$\"[298-379]T$	G3DSA:3.30.70.870
G3DSA:3.40.50.300	$\"[8-216]T$	G3DSA:3.40.50.300
PTHR23115	$\"[9-317]T$	PTHR23115
PTHR23115:SF40	$\"[9-317]T$	PTHR23115:SF40
SSF52540	$\"[8-215]T$	SSF52540

","BeTs to 13 clades of COG0481COG name: Membrane GTPase LepAFunctional Class: NThe phylogenetic pattern of COG0481 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000640 (Elongation factor G, C-terminus) with a combined E-value of 2.1e-49. IPB000640A 13-38 IPB000640B 50-72 IPB000640C 82-109 IPB000640D 116-144 IPB000640E 181-192 IPB000640F 404-438***** IPB000795 (GTP-binding elongation factor) with a combined E-value of 9.7e-29. IPB000795A 15-30 IPB000795B 85-116 IPB000795C 120-144***** IPB000178 (Initiation factor 2) with a combined E-value of 2.6e-16. IPB000178A 12-50 IPB000178B 82-114 IPB000178C 115-154","Residues 427-486 are 81% similar to a (GTP-BINDING ELONGATION FACTOR BIOSYNTHESIS PROTEOME) protein domain (PD011419) which is seen in LEPA_LACLA.Residues 188-298 are 81% similar to a (GTP-BINDING PROTEOME COMPLETE FACTOR) protein domain (PD004660) which is seen in LEPA_LACLA.Residues 488-602 are 90% similar to a (GTP-BINDING PROTEOME COMPLETE MEMBRANE) protein domain (PD004661) which is seen in LEPA_LACLA.Residues 25-183 are 34% similar to a (GTP-BINDING ADP-RIBOSYLATION MULTIGENE FAMILY ALPHA) protein domain (PD076602) which is seen in IF2_THEMA.Residues 435-480 are 47% similar to a (GTP-BINDING III ZK1236.1 CHROMOSOME) protein domain (PD383064) which is seen in YO81_CAEEL.Residues 16-143 are 36% similar to a (C215.12 GTP-BINDING CHROMOSOME II) protein domain (PD196535) which is seen in O94316_SCHPO.Residues 99-185 are 96% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in LEPA_LACLA.Residues 303-425 are 74% similar to a (GTP-BINDING PROTEOME COMPLETE MEMBRANE) protein domain (PD117013) which is seen in LEPA_LACLA.Residues 99-160 are 35% similar to a (FACTOR RELEASE GTP-BINDING CHAIN) protein domain (PD013442) which is seen in Q9RU41_DEIRA.Residues 56-93 are 97% similar to a (FACTOR GTP-BINDING BIOSYNTHESIS INITIATION ELONGATION) protein domain (PD336744) which is seen in LEPA_LACLA.Residues 427-486 are 48% similar to a (GTP-BINDING GUF1 MEMBRANE COMPLETE) protein domain (PD379297) which is seen in LEPA_ECOLI.Residues 11-54 are 97% similar to a (GTP-BINDING FACTOR ELONGATION BIOSYNTHESIS RESISTANCE) protein domain (PD000122) which is seen in LEPA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 09:04:33 2006","Thu Aug 3 09:04:33 2006","Thu Aug 3 09:04:33 2006","Wed Mar 6 10:43:27 2002","Wed Mar 6 10:43:27 2002","Wed Mar 6 10:43:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1271 is paralogously related (blast p-value < 1e-3) to SMu0496, a predicted GTP-binding protein; SMu0554,a predicted peptide chain release factor 3;translation elongation and release factor; SMu0324,a predicted translation elongation factor G; SMu0382,a predicted translation initiation factor and SMu0651, a predicted translation elongation factor EF-Tu.","Fri Mar 22 08:10:08 2002","Thu Aug 3 09:04:33 2006","pdb1FNMA Chain A, Structure Of Thermus Thermophilus Ef-G H573a 90 9e-019pdb1ELO Elongation Factor G Without Nucleotide >gi1633250... 90 9e-019pdb2EFGA Chain A, Translational Elongation Factor G Complexed... 90 9e-019","SMU.1394c","","Residues 11 to 193 (E-value = 4.7e-71) place SMu1271 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)Residues 214 to 284 (E-value = 1.3e-06) place SMu1271 in the GTP_EFTU_D2 family which is described as Elongation factor Tu domain 2 (PF03144)Residues 407 to 496 (E-value = 4.3e-40) place SMu1271 in the EFG_C family which is described as Elongation factor G C-terminus (PF00679)Residues 497 to 605 (E-value = 1.7e-82) place SMu1271 in the LepA_C family which is described as GTP-binding protein LepA C-terminus (PF06421)","Thu Aug 3 09:04:33 2006","","","","","","","1","","","SMU.1394c","107" "SMu1272","1323929","1323801","129","ATGACAGATCAAGAATTAGAACATTTGATAGTGACTGAACTTGAAAGTAAAAGATTAGATTTCACTTATTCTAAAGATATAACAGAATTTTTTGATGAAGCATTTCCTGAATATGATCAGAACTACTAA","3.90","-8.77","5134","MTDQELEHLIVTELESKRLDFTYSKDITEFFDEAFPEYDQNY","1323816","","hypothetical protein","Extracellular, Cytoplasm","No hits found in gapped BLAST.SMu1272 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 10:49:11 2002","Wed Mar 6 10:49:11 2002","Wed Mar 6 10:49:11 2002","Wed Mar 6 10:49:11 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1272 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 10:49:11 2002","","No significant hits to the NCBI PDB database.","SMU.1395c","","No significant hits to the Pfam 11.0 database","Wed Mar 6 10:49:11 2002","24379800","","","","","","1","","","SMU.1395c","" "SMu1273","1326075","1324324","1752","ATGAAATCGAAAACTGCTAAAATTACTTTGCTAAGCAGCCTTGCTTTGGCGGCTTTTGGAGCAACGAATGTTTTTGCAGATGAAGCATCAACTCAATTAAATTCTGATACTGTTGCAGCACCTACTGCTGATACACAAGCATCAGAACCGGCTGCAACAGAAAAAGAACAGTCTCCTGTTGTAGCTGTTGTCGAAAGTCACACACAAGGAAATACAACAACGACAACATCTCAAGTTACTTCTAAAGAATTGGAAGATGCTAAGGCTAATGCTAATCAGGAAGGTTTAGAAGTCACTGAAACTGAAGCTCAAAAACAGCCTTCGGTAGAAGCTGCAGATGCAGATAACAAAGCACAGGCACAAACAATTAATACAGCGGTAGCTGATTATCAAAAGGCAAAAGCTGAATTTCCTCAAAAACAAGAACAATATAATAAAGATTTTGAAAAGTATCAGTCTGATGTCAAGGAGTATGAAGCTCAAAAGGCAGCTTACGAGCAATATAAAAAAGAAGTTGCACAAGGTTTGGCATCTGGGCGTGTTGAAAAAGCCCAAGGACTTGTGTTTATTAATGAACCTGAGGCAAAACTTTCTATTGAGGGTGTTAATCAGTACCTAACAAAAGAAGCACGTCAAAAACATGCAACTGAAGATATTCTTCAGCAATATAATACTGATAATTATACAGCTTCTGATTTTACCCAAGCAAATCCATATGATCCAAAAGAAGATACTTGGTTCAAAATGAAAGTGGGAGATCAGATTTCAGTTACCTACGATAATATCGTTAATTCAAAATATAATGATAAAAAGATTAGTAAGGTAAAGATTAATTATACTCTCAATAGTTCAACGAATAATGAAGGCAGTGCACTGGTCAATTTGTTCCATGATCCAACTAAGACAATTTTCATTGGTGCACAGACATCTAATGCTGGCAGAAATGATAAAATCAGTGTGACGATGCAAATTATTTTTTATGATGAAAATGGCAATGAAATCGATTTAAGCGGCAATAATGCCATTATGAGTCTCTCATCGTTAAACCATTGGACGACTAAGTATGGCGATCATGTGGAAAAAGTAAACCTTGGGGATAATGAATTCGTTAAAATACCGGGCTCATCTGTTGACTTACATGGCAATGAAATCTATTCGGCTAAGGACAACCAATATAAAGCTAATGGTGCAACCTTTAATGGTGATGGAGCAGATGGCTGGGATGCTGTCAATGCTGATGGAACGCCACGTGCTGCGACGGCTTATTATGGTGCAGGTGCTATGACTTACAAGGGAGAACCCTTCACCTTTACTGTTGGTGGTAATGATCAAAACTTACCAACAACCATTTGGTTTGCGACTAATTCAGCTGTAGCTGTGCCTAAAGATCCGGGAGCTAAACCAACACCGCCAGAAAAACCAGAGTTGAAAAAACCTACTGTGACTTGGCATAAAAATCTTGTTGTTGAAACTAAAACTGAGGAAGTTCCTCCAGTGACACCACCAACAACTCCTGATGAACCAACGCCAGAAAAGCCAAAAACACCAGAGGATCCTCAATCACCTGTCGTAGCTAAGTCAGTAAGCTTTAGAACGGCAAGAAAAGGAGAAATGCGTGTTAGAGAGCGTGATTATCAACCGACTCTTCCACATGCTGGGGCTGCTAAACAAAATGGTTTAGCTACTCTTGGTGCTATTTCAACTGCATTTGCTGCGGCTACTTTGATTGCAGCTAGAAAAAAAGAAAACTAG","5.00","-15.01","63340","MKSKTAKITLLSSLALAAFGATNVFADEASTQLNSDTVAAPTADTQASEPAATEKEQSPVVAVVESHTQGNTTTTTSQVTSKELEDAKANANQEGLEVTETEAQKQPSVEAADADNKAQAQTINTAVADYQKAKAEFPQKQEQYNKDFEKYQSDVKEYEAQKAAYEQYKKEVAQGLASGRVEKAQGLVFINEPEAKLSIEGVNQYLTKEARQKHATEDILQQYNTDNYTASDFTQANPYDPKEDTWFKMKVGDQISVTYDNIVNSKYNDKKISKVKINYTLNSSTNNEGSALVNLFHDPTKTIFIGAQTSNAGRNDKISVTMQIIFYDENGNEIDLSGNNAIMSLSSLNHWTTKYGDHVEKVNLGDNEFVKIPGSSVDLHGNEIYSAKDNQYKANGATFNGDGADGWDAVNADGTPRAATAYYGAGAMTYKGEPFTFTVGGNDQNLPTTIWFATNSAVAVPKDPGAKPTPPEKPELKKPTVTWHKNLVVETKTEEVPPVTPPTTPDEPTPEKPKTPEDPQSPVVAKSVSFRTARKGEMRVRERDYQPTLPHAGAAKQNGLATLGAISTAFAAATLIAARKKEN","1324339","For other 'gbp' genes see SMu0018 (gbpB); SMu1916 (gbp) and SMu0760 (gbpB).","glucan-binding protein C","Extracellular, Periplasm, Cellwall","This sequence was previously published in GenBank gi1694933, gi1906775, gi227947) and defined as a glucan-binding protein C; PAGS-5; or cell surface antigen. Residues 1-583 are 81% similar to the glucan-binding protein C protein of S.mutans (gi1694933).Residues 88-464 are 28% similar to PAaA from S.cricetus (gi7670270). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1283 (1e-12).","

InterPro
IPR001899
Domain

Surface protein from Gram-positive cocci, anchor region
PF00746	$\"[541-581]T$	Gram_pos_anchor
TIGR01167	$\"[548-583]T$	LPXTG_anchor
PS50847	$\"[549-583]T$	GRAM_POS_ANCHORING

InterPro
IPR013574
Domain

Glucan-binding protein C
PF08363	$\"[166-455]T$	GbpC

noIPR
unintegrated

unintegrated
SSF74914	$\"[145-471]T$	SSF74914

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 459-583 are 48% similar to a (C GLUCAN-BINDING) protein domain (PD130695) which is seen in P97082_STRMU.Residues 255-458 are 91% similar to a (SIGNAL PRECURSOR CELL ANTIGEN) protein domain (PD005048) which is seen in P97082_STRMU.Residues 2-223 are 88% similar to a (CELL ANTIGEN PRECURSOR SIGNAL) protein domain (PD004340) which is seen in P97082_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 13:28:20 2007","Wed Mar 6 12:49:04 2002","Thu Feb 3 15:08:29 2005","Wed Mar 6 12:49:04 2002","","Wed Mar 6 12:49:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1273 is paralogously related (blast p-value < 1e-3) to SMu0556, a predicted cell surface antigen I/II, SpaP protein precursor, pac protein precursor; saliva-interacting protein;PAGS-5; SMu0630,a predicted hypothetical protein; SMu0057,a predicted conserved hypothetical protein and SMu0018, a predicted immunodominant glycoprotein IDG-60; general stress protein GSP-781; glucanbinding protein B.","Wed Mar 6 12:49:04 2002","","No significant hits to the NCBI PDB database.","SMU.1396c","","No significant hits to the Pfam 11.0 database","Wed Mar 6 12:49:04 2002","","","Nakano K, Matsumura M, Kawaguchi M, Fujiwara T, Sobue S, Nakagawa I, Hamada S, Ooshima T. Attenuation of glucan-binding protein C reduces the cariogenicity of Streptococcus mutans: analysis of strains isolated from human blood.J Dent Res. 2002 Jun;81(6):376-9.PMID: 12097427Sato Y, Okamoto K, Kizaki H. gbpC and pac gene mutations detected in Streptococcus mutans strain GS-5.Oral Microbiol Immunol. 2002 Aug;17(4):263-6.PMID: 12121478Sato Y, Senpuku H, Okamoto K, Hanada N, Kizaki H. Streptococcus mutans binding to solid phase dextran mediated by the glucan-binding protein C.Oral Microbiol Immunol. 2002 Aug;17(4):252-6.PMID: 12121476Sato,Y., Yamamoto,Y. and Kizaki,H.Cloning and sequence analysis of the gbpC gene encoding a novelglucan-binding protein of Streptococcus mutansInfect. Immun. 65 (2), 668-675 (1997)PubMed: 97162342Murakami Y, Nakano Y, Yamashita Y, Koga TIdentification of a frameshift mutation resulting in premature termination and loss of cell wall anchoring of the PAc antigen ofStreptococcus mutans GS-5.Infect Immun 1997 Feb;65(2):794-7PubMed: 9009344PMID: 9009344Kelly C, Evans P, Bergmeier L, Lee SF, Progulske-Fox A, Harris AC, Aitken A, Bleiweis AS, Lehner TSequence analysis of the cloned streptococcal cell surface antigen I/II.FEBS Lett 1989 Nov 20;258(1):127-32PubMed: 90076473PMID: 2687020Kelly C, Evans P, Ma JK, Bergmeier LA, Taylor W, Brady LJ, Lee SF, Bleiweis AS, Lehner TSequencing and characterization of the 185 kDa cell surface antigen of Streptococcus mutans.Arch Oral Biol 1990;35 Suppl:33S-38SPubMed: 1982405PMID: 1982405 Ma JK, Kelly CG, Munro G, Whiley RA, Lehner TConservation of the gene encoding streptococcal antigen I/II in oral streptococci.Infect Immun 1991 Aug;59(8):2686-94PubMed: 1855988PMID: 1855988 Okahashi N, Sasakawa C, Yoshikawa M, Hamada S, Koga TMolecular characterization of a surface protein antigen gene from serotype c Streptococcus mutans, implicated in dental caries.Mol Microbiol 1989 May;3(5):673-8PubMed: 2761390PMID: 2761390 Nomura R, Nakano K, Ooshima T.Contribution of glucan-binding protein C of Streptococcus mutans to bacteremia occurrence.Arch Oral Biol. 2004 Oct;49(10):783-8.PMID: 15308422","Kopec LK, Vacca Smith AM, Wunder D, Ng-Evans L, Bowen WH. Influence of antibody on the structure of glucans.Caries Res. 2002 Mar-Apr;36(2):108-15.PMID: 12037367Matsumoto M, Fujita K, Ooshima T.Binding of glucan-binding protein C to GTFD-synthesized soluble glucan in sucrose-dependent adhesion of Streptococcus mutans.Oral Microbiol Immunol. 2006 Feb;21(1):42-6.PMID: 16390340","Tue Apr 24 13:28:20 2007","Tue Apr 24 13:28:20 2007","1","","","SMU.1396c","" "SMu1274","1326523","1326284","240","ATGCAGTTTGTATGGGAATCAAATGGTAAGTTGAAAGGGGATGCAGAAGTGGAGAAGTTGACATTGCGAGCTCTCAGAGTGAATTATAGTTTAAGTCCCAAAGAGGTGGCTGATTGTCTAGGAATCCCTCAACACACTCTGCTAAGCTATGAAGAAGATAGTTCTGAAATTCCCATTCAACTGGCCAATGATTTGGCCAATTACTATGATATCAGTTTAGACTCTATTTTTTTTTGGTAA","4.20","-6.82","9023","MQFVWESNGKLKGDAEVEKLTLRALRVNYSLSPKEVADCLGIPQHTLLSYEEDSSEIPIQLANDLANYYDISLDSIFFW","1326299","","possible transcriptional repressor","Cytoplasm","Matches in gapped BLAST to different kinds of proteins. Residues 19-77 are 50% similar to Cro repressor from Lactococcus lactis gi14251161 and are 35% similar to conserved hypothetical protein from gi15675874 The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0169 (4e-06).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[22-76]T$	HTH_3
SM00530	$\"[21-76]T$	HTH_XRE
PS50943	$\"[22-76]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[11-76]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[17-79]T$	G3DSA:1.10.260.40

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 22-77 are 51% similar to a (REPRESSOR COMPLETE PROTEOME) protein domain (PD027337) which is seen in Q38329_VVVVV.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon May 6 10:36:40 2002","Fri Feb 1 20:42:54 2008","Fri Feb 1 20:41:37 2008","Thu Mar 7 08:25:47 2002","","Thu Mar 7 08:25:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1274 is paralogously related (blast p-value < 1e-3) to SMu1795, and SMu0151, all possible transcriptional regulators.","Thu Mar 7 08:25:47 2002","","No significant hits to the NCBI PDB database.","SMU.1397c","","Residues 22 to 76 (E-value = 2.4e-06) place SMu1274 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Mon May 6 10:36:40 2002","24379802","","Merritt J, Kreth J, Shi W, Qi F.LuxS controls bacteriocin production in Streptococcus mutans through a novel regulatory component.Mol Microbiol. 2005 Aug;57(4):960-9.PMID: 16091037","","Fri Feb 1 20:42:54 2008","","1","","","SMU.1397c","" "SMu1275","1326877","1327731","855","ATGAAGGCTATTTCTGCCAATCTTCAAAGACTTCTAGCTGAGAGCGGAATGAAACAATCTCACTTAGCTACTATTCTTAACATTCCTACAAGTAGTCTTAACGAATATGTTAAGGGAAAGAGTTTGCCAAAAATAGGGAATATTCAAAAAATCGCAGATTACTTTGGTTTACAAAAATCCGATATTGACCCTAGATTTGCAAGTAAAAAGGACTCTTCTACTCTTGATAAAATTAATCATATTGCCAAACAATTAGAAATGAAGAGACAGATAAAAGTCTTAGATTTCTGTTACCAACAATCAAAAGAACAAGATGAAACAGCAAGCTTGTCTGCCAGTGATGAAACGACTGAGGATAAAGTTGCTGACAAATCAAATCATACGCAGTATCAAAAGGTTGTTGATTCTTTTATTGCCAAAGAATTAAACGATCAGACAATTATTCATTGGGATAATGTGATAAAAGCTAAGGATTTGTATCAAACCTTTGGACGTCAATACGAAAACATTCAGATTTATGGTGAAGTTTCAGCTGGTACTGGTATCTGGGTTGGACATGAAAAACAAGAAACCATTAAATACCCAATACCAATTCCAGAACATGATATTGCTCTTATTGTCAATGGTAATAGTATGGAACCTTTATTTTACAACGGTGACGTTATTTTTGTTAAAAAGACTAAAGCTATCCATCACGGACAAATTATCGTTGTTATTGTAAATAATGAGGCATATGTCAAAAAACTCTACCGAAAAAACAAAGAAATTCGACTCATCTCATTAAATCCAGATTATGATGACATCATTTTAAAAGAAGATGATACAATTGAAGTCATCGGAACGGTCATTACCTAA","6.70","-1.11","32240","MKAISANLQRLLAESGMKQSHLATILNIPTSSLNEYVKGKSLPKIGNIQKIADYFGLQKSDIDPRFASKKDSSTLDKINHIAKQLEMKRQIKVLDFCYQQSKEQDETASLSASDETTEDKVADKSNHTQYQKVVDSFIAKELNDQTIIHWDNVIKAKDLYQTFGRQYENIQIYGEVSAGTGIWVGHEKQETIKYPIPIPEHDIALIVNGNSMEPLFYNGDVIFVKKTKAIHHGQIIVVIVNNEAYVKKLYRKNKEIRLISLNPDYDDIILKEDDTIEVIGTVIT","1327740","","repressor protein - phage associated","Cytoplasm","Several weak matches in gapped BLAST to repressor protein - phage associated: residues 5-283 are 33% similar to the protein in S.pyogenes (gi|15675873|). Residues 1-283 are 30% similar to the protein from S.30% (gi|15902045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1268 (9e-15).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[8-62]T$	HTH_3
SM00530	$\"[7-62]T$	HTH_XRE
PS50943	$\"[8-62]T$	HTH_CROC1

InterPro
IPR006198
Domain

Peptidase S24, S26A and S26B
PF00717	$\"[206-273]T$	Peptidase_S24

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[4-69]T$	Lambda_like_DNA

InterPro
IPR011056
Domain

Peptidase S24 and S26, C-terminal region
G3DSA:2.10.109.10	$\"[174-284]T$	Pept_S24_S26_C
SSF51306	$\"[167-283]T$	Pept_S24_S26_C

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[3-62]T$	G3DSA:1.10.260.40

","BeTs to 4 clades of COG1974COG name: SOS-response transcriptional repressors (LexA homologs, RecA-mediated autopeptidases)Functional Class: K,TThe phylogenetic pattern of COG1974 is ------vcEbrh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-69 are 39% similar to a (ORF REPRESSOR) protein domain (PD079971) which is seen in Q38327_VVVVV.Residues 199-283 are 45% similar to a (REPRESSOR DNA SOS HYDROLASE) protein domain (PD001529) which is seen in Q9G039_VVVVV.Residues 209-282 are 44% similar to a (REPRESSOR PROTEOME COMPLETE TRANSCRIPTION) protein domain (PD079968) which is seen in Q9MBT4_VVVVV.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 22 08:15:29 2002","Thu Mar 7 08:45:59 2002","Fri Oct 18 08:49:57 2002","Thu Mar 7 08:45:59 2002","","Thu Mar 7 08:45:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1275 is paralogously related (blast p-value < 1e-3) to SMu1842, a predicted conserved hypothetical protein (probable transcriptional regulator/repressor protein).","Fri Mar 22 08:15:29 2002","","No significant hits to the NCBI PDB database.","SMU.1398","","Residues 8 to 62 (E-value = 1.6e-08) place SMu1275 in the HTH_3 family which is described as Helix-turn-helix (PF01381)Residues 169 to 274 (E-value = 1.2e-14) place SMu1275 in the Peptidase_S24 family which is described as Peptidase family S24 (PF00717)","Thu Mar 7 08:45:59 2002","24379803","","Niu G, Okinaga T, Zhu L, Banas J, Qi F, Merritt J.Characterization of irvR, a novel regulator of the irvA-dependent pathway required for genetic competence and dextran-dependent aggregation in Streptococcus mutans.J Bacteriol. 2008 Nov;190(21):7268-74.PubMed: 18757533","Kaneko,J., Kimura,T., Kawakami,Y., Tomita,T. and Kamio,Y.Panton-valentine leukocidin genes in a phage-like particle isolated from mitomycin C-treated Staphylococcus aureus V8 (ATCC 49775)Biosci. Biotechnol. Biochem. 61 (11), 1960-1962 (1997)PubMed: 9404084","","Thu Mar 7 08:45:59 2002","1","","","SMU.1398","" "SMu1276","1327999","1328319","321","TTGAAAATATTTAGTTTTGGAACCATTCGAAACAACACAGCTCTAAAACCTAACTATGATGACACAACAGCTTTTAGCGGTTTTGGAACCATTCGAAACAACACAGCTCTAAAACAGAGCACTAACTGCGCTAGCTGGTTCAATCGTTTTGGAACCATTCGAAACAACACAGCTCTAAAACTCACCATATTAATTAATGGCGTTTCCTTTTGTTTTGGAACCATTCGAAACAACACAGCTCTAAAACCTCGTGGACCAATTTTTGTCTCGACATTTCGTAATCGCGCCATTCATCTCAGCCAGATTTCAGCTTCAAAATGA","12.10","12.12","11746","MKIFSFGTIRNNTALKPNYDDTTAFSGFGTIRNNTALKQSTNCASWFNRFGTIRNNTALKLTILINGVSFCFGTIRNNTALKPRGPIFVSTFRNRAIHLSQISASK","1328328","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.SMu1276 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 08:48:16 2002","Thu Mar 7 08:48:16 2002","Thu Mar 7 08:48:16 2002","Thu Mar 7 08:48:16 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1276 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 08:48:16 2002","","No significant hits to the NCBI PDB database.","SMU.1399","","No significant hits to the Pfam 11.0 database","Thu Mar 7 08:48:16 2002","24379804","","","","","","1","","","SMU.1399","" "SMu1277","1328777","1328400","378","ATGTTAAAATCATATCCTGTAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTACGCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTGTTGGCATCTTATCTTGATGAAGGGTTGGTTCTACCCATTTCAAGCGATATTCAGAAAATATCTGTTGAAGATGGTTTTGCGACCATGATTCAAGCTGATCCTAGTCCTTATCTCAAAAATAACAAAGCTATTCGGAAAAATGTTACCGTGCCTGAGTGGTTGATACGATTAGCAGACCGTGACCGAGTAAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA","4.70","-5.76","14248","MLKSYPVIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGLVLPISSDIQKISVEDGFATMIQADPSPYLKNNKAIRKNVTVPEWLIRLADRDRVNYSEVLTKALEKKLQL","1328415","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-124 are 30% similar to S.pneumoniae (gi|15901615|) and residues 5-125 are 28% similar to Clostridium perfringens (gi|15081508|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1835 (2e-14).","

InterPro
IPR005357
Domain

Protein of unknown function UPF0150
PF03681	$\"[4-49]T$	UPF0150

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-123 are 26% similar to a (ORF17) protein domain (PD202676) which is seen in Q9ZXB8_BPPH1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 08:51:39 2002","Thu Mar 7 08:51:39 2002","Thu Mar 7 08:51:39 2002","Thu Mar 7 08:51:39 2002","","Thu Mar 7 08:51:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1277 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 08:51:39 2002","","No significant hits to the NCBI PDB database.","SMU.1400c","","Residues 3 to 63 (E-value = 5.9e-15) place SMu1277 in the UPF0150 family which is described as Uncharacterised protein family (UPF0150) (PF03681)","Thu Mar 7 08:51:39 2002","24379805","","","","","","1","","","SMU.1400c","" "SMu1278","1329655","1329083","573","ATGGTGAGAAATCTTTATCAATATGATGAAGATAGTGAACTTAAATTTTTTAATAGAAAATTTAAGAGTCTGAAACCATCTGAGTTAATGCTTGTGACAGATATTTTAGGTTATGATGTCAATGCCCCGTCCTTGCTGAAGTTGGTTCACGCTGATTTAGAAAATCAGTTTAATGAAAAACCAGAGGTTAAGTCTATGGTTGAAAAACTGGCAAATACCATTACGGAATTAATTGCTTATGAATGTTTAGAAAATGAATTGGACTTAGAATATGATGAGATTACTATTTTAGAGTTAATCAAAGCTTTAGGCGTCAAAATTGAAACACAAAGTGATACCATTTTTGAAAAAATGTTTGAAGTCCTTCAAGTTTATAAGTATCTAAATAAAAAGAAGCTTCTCGTTTTTATCAATACTTTATCCTATTTTAAAAGAGAAGAAATCGCGCAAATTCTAGAATATATTCACTTATCCGATATGGTTGTTTTATTTCTTGAACCCCGTAAAATTGATGGTTTTGCTCAATATATTTTAGATGAAGATTATTTCTTGATAACAGAAAGCAACAACTAA","4.40","-13.55","22447","MVRNLYQYDEDSELKFFNRKFKSLKPSELMLVTDILGYDVNAPSLLKLVHADLENQFNEKPEVKSMVEKLANTITELIAYECLENELDLEYDEITILELIKALGVKIETQSDTIFEKMFEVLQVYKYLNKKKLLVFINTLSYFKREEIAQILEYIHLSDMVVLFLEPRKIDGFAQYILDEDYFLITESNN","1329098","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 1-188 are 63% similar to S.pyogenes (gi|15675044|) and residues 5-187 are 55% similar to Listeria innocua (gi|16801803|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0897 (4e-65).","

InterPro
IPR010146
Family

CRISPR-associated protein, SAG0897
TIGR01866	$\"[1-188]T$	cas_Csn2

InterPro
IPR003799
Family

Protein of unknown function DUF196
TIGR01573	$\"[1-100]T$	cas2

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-100 are 44% similar to a (PROTEOME COMPLETE CJ1521C NMA0629) protein domain (PD354774) which is seen in Q9JVY1_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 08:57:54 2002","Thu Mar 7 08:57:54 2002","Thu Mar 7 08:57:54 2002","Thu Mar 7 08:57:54 2002","","Thu Mar 7 08:57:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1279 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 08:57:54 2002","","No significant hits to the NCBI PDB database.","SMU.1403c","","No significant hits to the Pfam 11.0 database","Thu Mar 7 08:57:54 2002","24379807","","","","","","1","","","SMU.1403c","1014" "SMu1280","1330942","1330076","867","ATGGGCTGGCGGACAGTGGTTGTTAATACGCATTCCAAGTTGTCTTATAAGAACAACCACTTGATTTTTAAAGATGCTTATCAGACAGAGATGATTCATCTGTCTGAGATTGACATCTTATTACTTGAGACAACAGATATTGTTTTGTCAACTATGCTAATCAAACGCTTGGTTGATGAGAATATTTTGGTCATTTTTTGTGATGACAAACGTCTGCCAACAGCCATGCTCATGCCTTACTATGCGCGTCACGATTCCAGCTTGCAGCTGAGTCATCAGATTTCTTGGACAGAAGAAGTGAAATGCGATGTCTGGACAACAATCATCGCTCAAAAGATTTTGAATCAGTCATGTTATTTGGGAGAATGTTTTTATTTTGAAAAATCTCAGTCAATTATGGATTTATATCATGACTTAGAGCCTTTTGACCCTAGTAATCGAGAAGGACATTCTGCGCGGATTTATTTCAATACCTTATTTGGAAATGTTTTTTCCAGAGAACAAGATAATGATATTAATGCAGGTCTTGACTATGGTTATACGCTGCTGTTAAGTATGTTTGCGCGTGAAGTGGTTGTATCTGGCTGTATGACACAATTTGGTCTCAAGCATGCCAACCAATTCAATCAGTTTAACTTTGCCAGTGATATTATGGAGCCTTTTCGTCCAATTGTTGACCGTATTGTTTATGAAAATCGAAATAACTCTTTTATTAAAATAAAACGTGAGCTATTCAGCATGTTTTCAGACACCTATCTTTATAATAATAAGGAGATGTATTTGACAAATATTGTCAGCGATTATACCAAAAAGGTAATCAAGGCGCTGAATAATGATGGGAAAGGAGTTCCTGAGTTTAGGATATGA","5.90","-5.30","33720","MGWRTVVVNTHSKLSYKNNHLIFKDAYQTEMIHLSEIDILLLETTDIVLSTMLIKRLVDENILVIFCDDKRLPTAMLMPYYARHDSSLQLSHQISWTEEVKCDVWTTIIAQKILNQSCYLGECFYFEKSQSIMDLYHDLEPFDPSNREGHSARIYFNTLFGNVFSREQDNDINAGLDYGYTLLLSMFAREVVVSGCMTQFGLKHANQFNQFNFASDIMEPFRPIVDRIVYENRNNSFIKIKRELFSMFSDTYLYNNKEMYLTNIVSDYTKKVIKALNNDGKGVPEFRI","1330091","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 2-288 are 87% similar to S.pyogenes (gi|15675042|) and residues 1-231 are 31% similar to Pasteurella multocida (gi|15602991|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0895 (1e-150).","

InterPro
IPR002729
Family

Protein of unknown function DUF48
PD008695	$\"[182-278]T$	DUF48
TIGR00287	$\"[5-284]T$	cas1

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-231 are 31% similar to a (PROTEOME COMPLETE CJ1522C NMA0630) protein domain (PD360113) which is seen in Q9CLT3_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 09:13:59 2002","Thu Mar 7 08:58:37 2002","Thu Mar 7 09:13:59 2002","Thu Mar 7 08:58:37 2002","","Thu Mar 7 08:58:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1280 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 08:58:37 2002","","No significant hits to the NCBI PDB database.","SMU.1404c","","No significant hits to the Pfam 11.0 database","Thu Mar 7 08:58:37 2002","24379808","","","","","","1","","","SMU.1404c","794" "SMu1281","1334979","1330942","4038","ATGAAAAAACCTTACTCTATTGGACTTGATATTGGAACCAATTCTGTTGGTTGGGCTGTTGTGACAGATGACTACAAAGTTCCTGCTAAGAAGATGAAGGTTCTGGGAAATACAGATAAAAGTCATATCGAGAAAAATTTGCTTGGCGCTTTATTATTTGATAGCGGGAATACTGCAGAAGACAGACGGTTAAAGAGAACTGCTCGCCGTCGTTACACACGTCGCAGAAATCGTATTTTATATTTGCAAGAGATTTTTTCAGAAGAAATGGGCAAGGTAGATGATAGTTTCTTTCATCGTTTAGAGGATTCTTTTCTTGTTACTGAGGATAAACGAGGAGAGCGCCATCCCATTTTTGGGAATCTTGAAGAAGAAGTTAAGTATCATGAAAATTTTCCAACCATTTATCATTTGCGGCAATATCTTGCGGATAATCCAGAAAAAGTTGATTTGCGTTTAGTTTATTTGGCTTTGGCACATATAATTAAGTTTAGAGGTCATTTTTTAATTGAAGGAAAGTTTGATACACGCAATAATGATGTACAAAGACTGTTTCAAGAATTTTTAGCAGTCTATGATAATACTTTTGAGAATAGTTCGCTTCAGGAGCAAAATGTTCAAGTTGAAGAAATTCTGACTGATAAAATCAGTAAATCTGCTAAGAAAGATAGAGTTTTGAAACTTTTTCCTAATGAAAAGTCTAATGGCCGCTTTGCAGAATTTCTAAAACTAATTGTTGGTAATCAAGCTGATTTTAAAAAGCATTTTGAATTAGAAGAGAAAGCACCATTGCAATTTTCTAAAGATACTTATGAAGAAGAGTTAGAAGTACTATTAGCTCAAATTGGAGATAATTACGCAGAGCTCTTTTTATCAGCAAAGAAACTGTATGATAGTATCCTTTTATCAGGGATTTTAACAGTTACTGATGTTGGTACCAAAGCGCCTTTATCTGCTTCGATGATTCAGCGATATAATGAACATCAGATGGATTTAGCTCAGCTTAAACAATTCATTCGTCAGAAATTATCAGATAAATATAACGAAGTTTTTTCTGATGTTTCAAAAGACGGCTATGCGGGTTATATTGATGGGAAAACAAATCAAGAAGCTTTTTATAAATACCTTAAAGGTCTATTAAATAAGATTGAGGGAAGTGGCTATTTCCTTGATAAAATTGAGCGTGAAGATTTTCTAAGAAAGCAACGTACCTTTGACAATGGCTCTATTCCACATCAGATTCATCTTCAAGAAATGCGTGCTATCATTCGTAGACAGGCTGAATTTTATCCGTTTTTAGCAGACAATCAAGATAGGATTGAGAAATTATTGACTTTCCGTATTCCCTACTATGTTGGTCCATTAGCGCGCGGAAAAAGTGATTTTGCTTGGTTAAGTCGGAAATCGGCTGATAAAATTACACCATGGAATTTTGATGAAATCGTTGATAAAGAATCCTCTGCAGAAGCTTTTATCAATCGTATGACAAATTATGATTTGTACTTGCCAAATCAAAAAGTTCTTCCTAAACATAGTTTATTATACGAAAAATTTACTGTTTACAATGAATTAACAAAGGTTAAATATAAAACAGAGCAAGGAAAAACAGCATTTTTTGATGCCAATATGAAGCAAGAAATCTTTGATGGCGTATTTAAGGTTTATCGAAAAGTAACTAAAGATAAATTAATGGATTTCCTTGAAAAAGAATTTGATGAATTTCGTATTGTTGATTTAACAGGTCTGGATAAAGAAAATAAAGTATTTAACGCTTCTTATGGAACTTATCATGATTTGTGTAAAATTTTAGATAAAGATTTTCTCGATAATTCAAAGAATGAAAAGATTTTAGAAGATATTGTGTTGACCTTAACGTTATTTGAAGATAGAGAAATGATTAGAAAACGTCTAGAAAATTACAGTGATTTATTGACCAAAGAACAAGTGAAAAAGCTGGAAAGACGTCATTATACTGGTTGGGGAAGATTATCAGCTGAGTTAATTCATGGTATTCGCAATAAAGAAAGCAGAAAAACAATTCTTGATTATCTCATTGATGATGGCAATAGCAATCGGAACTTTATGCAACTGATTAACGATGATGCTCTTTCTTTCAAAGAAGAGATTGCTAAGGCACAAGTTATTGGAGAAACAGACAATCTAAATCAAGTTGTTAGTGATATTGCTGGCAGCCCTGCTATTAAAAAAGGAATTTTACAAAGCTTGAAGATTGTTGATGAGCTTGTCAAAATTATGGGACATCAACCTGAAAATATCGTCGTGGAGATGGCGCGTGAAAACCAGTTTACCAATCAGGGACGACGAAATTCACAGCAACGTTTGAAAGGTTTGACAGATTCTATTAAAGAATTTGGAAGTCAAATTCTTAAAGAACATCCGGTTGAGAATTCACAGTTACAAAATGATAGATTGTTTCTATATTATTTACAAAACGGCAGAGATATGTATACTGGAGAAGAATTGGATATTGATTATCTAAGCCAGTATGATATAGACCATATTATCCCGCAAGCTTTTATAAAGGATAATTCTATTGATAATAGAGTATTGACTAGCTCAAAGGAAAATCGTGGAAAATCGGATGATGTACCAAGTAAAGATGTTGTTCGTAAAATGAAATCCTATTGGAGTAAGCTACTTTCGGCAAAGCTTATTACACAACGTAAATTTGATAATTTGACAAAAGCTGAACGAGGTGGATTGACCGACGATGATAAAGCTGGATTCATCAAGCGTCAATTAGTAGAAACACGACAAATTACCAAACATGTAGCACGTATTCTGGACGAACGATTTAATACAGAAACAGATGAAAACAACAAGAAAATTCGTCAAGTAAAAATTGTGACCTTGAAATCAAATCTTGTTTCCAATTTCCGTAAAGAGTTTGAACTCTACAAAGTGCGTGAAATTAATGACTATCATCATGCACATGATGCCTATCTCAATGCTGTAATTGGAAAGGCTTTACTAGGTGTTTACCCACAATTGGAACCTGAATTTGTTTATGGTGATTATCCTCATTTTCATGGACATAAAGAAAATAAAGCAACTGCTAAGAAATTTTTCTATTCAAATATTATGAACTTCTTTAAAAAAGATGATGTCCGTACTGATAAAAATGGTGAAATTATCTGGAAAAAAGATGAGCATATTTCTAATATTAAAAAAGTGCTTTCTTATCCACAAGTTAATATTGTTAAGAAAGTAGAGGAGCAAACGGGAGGATTTTCTAAAGAATCTATCTTGCCGAAAGGTAATTCTGACAAGCTTATTCCTCGAAAAACGAAGAAATTTTATTGGGATACCAAGAAATATGGAGGATTTGATAGCCCGATTGTTGCTTATTCTATTTTAGTTATTGCTGATATTGAAAAAGGTAAATCTAAAAAATTGAAAACAGTCAAAGCCTTAGTTGGTGTCACTATTATGGAAAAGATGACTTTTGAAAGGGATCCAGTTGCTTTTCTTGAGCGAAAAGGCTATCGAAATGTTCAAGAAGAAAATATTATAAAGTTACCAAAATATAGTTTATTTAAACTAGAAAACGGACGAAAAAGGCTATTGGCAAGTGCTAGGGAACTTCAAAAGGGAAATGAAATCGTTTTGCCAAATCATTTAGGAACCTTGCTTTATCACGCTAAAAATATTCATAAAGTTGATGAACCAAAGCATTTGGACTATGTTGATAAACATAAAGATGAATTTAAGGAGTTGCTAGATGTTGTGTCAAACTTTTCTAAAAAATATACTTTAGCAGAAGGAAATTTAGAAAAAATCAAAGAATTATATGCACAAAATAATGGTGAAGATCTTAAAGAATTAGCAAGTTCATTTATCAACTTATTAACATTTACTGCTATAGGAGCACCGGCTACTTTTAAATTCTTTGATAAAAATATTGATCGAAAACGATATACTTCAACTACTGAAATTCTCAACGCTACCCTCATCCACCAATCCATCACCGGTCTTTATGAAACGCGGATTGATCTCAATAAGTTAGGAGGAGACTAA","9.70","22.85","156626","MKKPYSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTAEDRRLKRTARRRYTRRRNRILYLQEIFSEEMGKVDDSFFHRLEDSFLVTEDKRGERHPIFGNLEEEVKYHENFPTIYHLRQYLADNPEKVDLRLVYLALAHIIKFRGHFLIEGKFDTRNNDVQRLFQEFLAVYDNTFENSSLQEQNVQVEEILTDKISKSAKKDRVLKLFPNEKSNGRFAEFLKLIVGNQADFKKHFELEEKAPLQFSKDTYEEELEVLLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQKLSDKYNEVFSDVSKDGYAGYIDGKTNQEAFYKYLKGLLNKIEGSGYFLDKIEREDFLRKQRTFDNGSIPHQIHLQEMRAIIRRQAEFYPFLADNQDRIEKLLTFRIPYYVGPLARGKSDFAWLSRKSADKITPWNFDEIVDKESSAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKTEQGKTAFFDANMKQEIFDGVFKVYRKVTKDKLMDFLEKEFDEFRIVDLTGLDKENKVFNASYGTYHDLCKILDKDFLDNSKNEKILEDIVLTLTLFEDREMIRKRLENYSDLLTKEQVKKLERRHYTGWGRLSAELIHGIRNKESRKTILDYLIDDGNSNRNFMQLINDDALSFKEEIAKAQVIGETDNLNQVVSDIAGSPAIKKGILQSLKIVDELVKIMGHQPENIVVEMARENQFTNQGRRNSQQRLKGLTDSIKEFGSQILKEHPVENSQLQNDRLFLYYLQNGRDMYTGEELDIDYLSQYDIDHIIPQAFIKDNSIDNRVLTSSKENRGKSDDVPSKDVVRKMKSYWSKLLSAKLITQRKFDNLTKAERGGLTDDDKAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIRQVKIVTLKSNLVSNFRKEFELYKVREINDYHHAHDAYLNAVIGKALLGVYPQLEPEFVYGDYPHFHGHKENKATAKKFFYSNIMNFFKKDDVRTDKNGEIIWKKDEHISNIKKVLSYPQVNIVKKVEEQTGGFSKESILPKGNSDKLIPRKTKKFYWDTKKYGGFDSPIVAYSILVIADIEKGKSKKLKTVKALVGVTIMEKMTFERDPVAFLERKGYRNVQEENIIKLPKYSLFKLENGRKRLLASARELQKGNEIVLPNHLGTLLYHAKNIHKVDEPKHLDYVDKHKDEFKELLDVVSNFSKKYTLAEGNLEKIKELYAQNNGEDLKELASSFINLLTFTAIGAPATFKFFDKNIDRKRYTSTTEILNATLIHQSITGLYETRIDLNKLGGD","1330957","","conserved hypothetical protein","Cytoplasm, Membrane","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-1345 are 62% similar to S.pyogenes (gi|15674253) and 57% similar to Listeria innocua (gi|16801805|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0894 (0.0).","

InterPro
IPR002711
Domain

HNH endonuclease
PF01844	$\"[817-870]T$	HNH

InterPro
IPR003615
Domain

HNH nuclease
SM00507	$\"[810-864]T$	HNHc

InterPro
IPR010145
Family

CRISPR-associated protein, SAG0894
TIGR01865	$\"[4-1042]T$	cas_Csn1

noIPR
unintegrated

unintegrated
SSF53067	$\"[3-27]T$	SSF53067

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 492-1027 are 21% similar to a (PROTEOME COMPLETE CJ1523C NMA0631) protein domain (PD361337) which is seen in Q9JVX9_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 09:20:36 2002","Thu Mar 7 09:20:36 2002","Thu Mar 7 09:20:36 2002","Thu Mar 7 09:20:36 2002","","Thu Mar 7 09:20:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1281 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 09:20:36 2002","","No significant hits to the NCBI PDB database.","SMU.1405c","","No significant hits to the Pfam 11.0 database","Thu Mar 7 09:20:36 2002","24379809","","","","","","1","","","SMU.1405c","923" "SMu1282","1336226","1335360","867","ATGAAATTAGTTGCTATTGTTGGTTCTAATGCCTCCTTTTCCTATAATCGTTTATTGTTGCAATTTATTAAAGAGCGGTTCGGTCAAGCTTTTGCATTGGAGATTTTGGAAATTAAAGAGCTCCCTCTTTTCAATCAAGATAGTAGTGCTGCAGATTGTCCTCTTATTCAAAAGCTTAATGAAGATATCTTAAATGCAGATGGCATCATTATTGCGACAGCAGAGCACAATCAAACCATTACAGCCAGTTTAAAATCCATGCTTGAATGGTTATCTTACCAGCTTCATCCCTTTAAAAATAAACCTGTCATGATTGTCGGAGCTTCTTATTATAATCAGGGAACTTCTCATGCACAAGAGCACTTAAGGCAAATCCTAAATGCTCCCGGTCTTGATGCTTGGGTCATGCCCGGAAATGAATTTTTTCTAGGGAATGCCTCAGAAGTCTTTGATGAAAATAATCAAATAAAAGATGATGATACCGTTATTTATCTTGCGCAATGTTTACAACGTTTTATTCGCTATGTCACTGTTGTTCAGGAGTTAAAGGGAGATTCCATTCAACTTAGTGATGCAATTTCAGGAGCATCAGAATCAGTCCAAGAGGACTCTGCTGCATCTGCTATGCTAGAAAAGCGATTGTCACTACAAAAGAAAGAGACCAATACTCCCTTTGAAAGAGCACTAGATAAAACTTATGGACCGGCTTTGAAAGATACACTTGAAGATCCATTTGATAAGGATTTAGATGCCCAATACAAAGCAATCAAAAAACAACCAATACCTTTTGAAAAAGCCTTAGACAATATCTTTGGAAAAGATTTAGGTATCGAAACAACCGATCCGCTGGATAATTTATTAAGATAA","4.60","-13.11","32263","MKLVAIVGSNASFSYNRLLLQFIKERFGQAFALEILEIKELPLFNQDSSAADCPLIQKLNEDILNADGIIIATAEHNQTITASLKSMLEWLSYQLHPFKNKPVMIVGASYYNQGTSHAQEHLRQILNAPGLDAWVMPGNEFFLGNASEVFDENNQIKDDDTVIYLAQCLQRFIRYVTVVQELKGDSIQLSDAISGASESVQEDSAASAMLEKRLSLQKKETNTPFERALDKTYGPALKDTLEDPFDKDLDAQYKAIKKQPIPFEKALDNIFGKDLGIETTDPLDNLLR","1335375","","conserved hypothetical protein (possible oxidoreductase)","Cytoplasm","Matches in gapped BLAST to hypotheticals and to putative oxidoreductases. Residues 1-183 are 59% similar to gi|15903369|, a hypothetical from S.pneumoniae. Residues 1-188 are 45% similar to gi|15672349| from Lactococcus lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1083 (2e-59).","

InterPro
IPR005025
Domain

NADPH-dependent FMN reductase
PF03358	$\"[1-106]T$	FMN_red

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[1-187]T$	G3DSA:3.40.50.360
SSF52218	$\"[1-174]T$	SSF52218

","BeTs to 3 clades of COG0431COG name: Predicted flavoproteinFunctional Class: RThe phylogenetic pattern of COG0431 is ----y--cebr---gp-----Number of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 2-131 are 51% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH PHOSPHODIESTERASE) protein domain (PD009603) which is seen in Q9CIJ0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 09:27:00 2002","Fri Jan 3 15:16:53 2003","Fri Jan 3 15:16:53 2003","Thu Mar 7 09:26:37 2002","","Thu Mar 7 09:26:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1282 is paralogously related (blast p-value < 1e-3) to SMu0998, SMu0161, SMu0997,SMu0112, all conserved hypotheticals except SMu0162, a predicted fumarate reductase.","Thu Mar 7 09:27:00 2002","","No significant hits to the NCBI PDB database.","SMU.1406c","","Residues 1 to 163 (E-value = 1e-08) place SMu1282 in the FMN_red family which is described as NADPH-dependent FMN reductase (PF03358)","Thu Mar 7 09:26:37 2002","24379810","","","","","","1","","","SMU.1406c","" "SMu1283","1337178","1336342","837","TTGGTAACGGAGTTTTCTTTAGACATTCTTCTAAAGATTATTAAGCTCGCTCGTTCAACCTATTATTACCACTTAAAGCAGCTAGATAAAAGCAATAAAGATCATGCTATTAAAGCTGAAATTCAAGCTATTTTTACTGAGCACAAAGGAAATTATGGTTATCGTCGAATGACTCTTGAATTGAGAAATCGTGGCTTCTTGGTAAATCATAAAAAGGTTCAACGTCTAATGAAAGTTCTTGGTTTGGAGGCTCGTATTCGTCGCAAACGGAAGTATTCTTCCTACCAAGGAGAGGTGGGCAAGAAAGCAGACAACCTTATTCAACGCCAATTTGAAGCATCAAAACCAATGGAAAAGTGCTACACAGATGTGACAGAATTTGCCATTCCAGCAAGCGGTCAAAAGCTCTATTTGTCACCAGTTTTAGATGGTTTCAACAGTGAAATTATTGCTTATAACCTTTCTACGTCACCGAACTTGATACAAGTGAAAGCTATGCTAGAACAGGCTTTCACAGAGAAACATTACACAAATACTATTCTTCATAGTGACCAAGGCTGGCAATACCAGCATGATTTTTATCATCAATTTTTAGAGAACAAGGGGATTCAGCCGTCCATGTCACGTAAAGGAAACAGCCCAGATAATGGCATGATGGAATCTTTCTTTGGCATTTTGAAATCCGAAATGTTTTACGGTTATGAGAAGACATTTAAGTCACTTAAGCAATTGGAACAAGCTATTGTAGACTATATTGATTATTACAACAACAAACGTATTAAGGTAAAACTAAAAGGACTTAGTCCTGTACAGTACAGAACGAAATCCTTTACTTAA","10.40","17.88","32568","MVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGNYGYRRMTLELRNRGFLVNHKKVQRLMKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQFEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIAYNLSTSPNLIQVKAMLEQAFTEKHYTNTILHSDQGWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT","1336357","","transposase, IS3-Spn1","Cytoplasm","This sequence was previously published in GenBank as gi3873218, a predicted transposase. Residues 204-278 are 97% similar to residues 1-75 of S.mutans.Furthermore, residues 2-277 are 84% similar to gi8163693, a predicted IS3-Spn1 transposase. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (1e-122).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[112-274]T$	rve
PS50994	$\"[112-277]T$	INTEGRASE

noIPR
unintegrated

unintegrated
PD688335	$\"[35-76]T$	Q8DVC7_STRMU_Q8DVC7;
G3DSA:3.30.420.10	$\"[137-278]T$	no description
signalp	$\"[1-19]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 231-273 are 51% similar to a (ELEMENT ORFB B. CRYIIB) protein domain (PD410106) which is seen in Q57057_BACAN.Residues 163-203 are 82% similar to a (TRANSPOSASE ELEMENT COMPLETE) protein domain (PD335900) which is seen in Q9KK23_STRPN.Residues 122-162 are 95% similar to a (TRANSPOSASE ELEMENT INSERTION COMPLETE) protein domain (PD006527) which is seen in Q9KK23_STRPN.Residues 12-150 are 27% similar to a (TRANSPOSASE) protein domain (PD102854) which is seen in Q48525_LACCA.Residues 59-119 are 73% similar to a (TRANSPOSASE COMPLETE ELEMENT OF) protein domain (PD245714) which is seen in Q9KK23_STRPN.Residues 206-273 are 95% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in Q9KK23_STRPN.Residues 206-256 are 86% similar to a (TRANSPOSASE PLASMID COMPLETE OF) protein domain (PD000334) which is seen in Q53640_STRAG.Residues 5-56 are 76% similar to a (TNIA ISTB TNIBDELTA1 COMPLETE) protein domain (PD402756) which is seen in Q9KK23_STRPN.Residues 125-198 are 41% similar to a (TRANSPOSASE OF PROTEOME COMPLETE) protein domain (PD395630) which is seen in O50351_LACHE.Residues 10-56 are 48% similar to a (TRANSPOSASE ELEMENT PROTEOME FOR) protein domain (PD195495) which is seen in INSK_ECOLI.","","Thu Nov 29 18:50:06 2001","Thu Nov 29 18:50:06 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 09:51:45 2002","Thu Mar 7 09:49:01 2002","Tue Sep 26 14:59:48 2006","Thu Mar 7 09:49:01 2002","","Thu Mar 7 09:49:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1283 is paralogously related (blast p-value < 1e-3) to SMu1719, SMu0695, SMu0395, SMu1258, SMu0514, SMu0798, SMu1250, SMu0934, SMu0537, SMu1237, SMu1236, and SMu1235, all transposase-related.","Thu Mar 7 09:49:01 2002","","No significant hits to the NCBI PDB database.","SMU.1407c","Thu Nov 29 18:50:06 2001","Residues 112 to 274 (E-value = 1.2e-40) place SMu1283 in the rve family which is described as Integrase core domain (PF00665)","Thu Mar 7 09:49:01 2002","24379811","","","","Tue Sep 26 14:59:48 2006","","1","","","SMU.1407c","" "SMu1284","1337690","1337172","519","ATGAAATTGACTTATGAAGATAAAGTTCTCATCTATGAACTGAAAAACCAAGGGTATAGCTTAGAGCAGCTTTCAAATAAATTTGGGATAAAAATTTCTAATCTTAGCTACATGATTAAATTGATTGATCATTACGGAATAGAGATCGTCAAAAAAGGAAAGAATCGTTACTATTCTCCTGAACTAAAACAAGAAATCATTGATAAAGTTCTTCTTGAAGGTCGTTCACAAATAAGGGTGTCTCTAGATTATGCTCTTCCAAGTCATGGAATGTTGCCTAATTGGATAGCACAATACAAGAAAAATAGGTATACTATTGTTGAGAAAACAAGAGGGAGACCACCTAAAATGGGACGTAAGCCAAAGAAGAAATCGGAAGAAATGACAGAGCTAGAGCAACTTCAGAAAGAATTAGAATATCTGAGAGCGGAGAATGCTGTTCTAAAAAAGTTGAGAGAACTCCGATTGAGGGAAGAAAAAGAGCAAGAAGAAAAACGGAAATTGTCCGAGGATTGGTAA","10.40","10.49","20606","MKLTYEDKVLIYELKNQGYSLEQLSNKFGIKISNLSYMIKLIDHYGIEIVKKGKNRYYSPELKQEIIDKVLLEGRSQIRVSLDYALPSHGMLPNWIAQYKKNRYTIVEKTRGRPPKMGRKPKKKSEEMTELEQLQKELEYLRAENAVLKKLRELRLREEKEQEEKRKLSEDW","1337187","","transposase, IS861-associated, IS3 family","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and IS861 associated segments: residues 1-108 are 73% similar to the protein in S.pneumoniae (gi8163692) and are 62% similar to the protein in S.pyogenes (gi15674401).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1526 (9e-37).","

InterPro
IPR002514
Family

Transposase IS3/IS911
PF01527	$\"[55-148]T$	Transposase_8

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[3-96]T$	Homeodomain_like

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 38-108 are 67% similar to a (DOMAIN OF UNKNO N) protein domain (PD354820) which is seen in Q53639_STRAG.Residues 1-37 are 78% similar to a (DOMAIN OF UNKNO N) protein domain (PD230559) which is seen in Q9KK22_STRPN.","","Thu Nov 29 18:51:10 2001","Thu Nov 29 18:51:10 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 3 15:37:26 2003","Tue Sep 26 15:00:34 2006","Tue Sep 26 15:00:34 2006","Thu Mar 7 09:55:14 2002","","Thu Mar 7 09:55:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1284 is paralogously related (blast p-value < 1e-3) to SMu1720, SMu1257, SMu0694, SMu0515, and SMu0396, all predicted conserved hypotheticals,possibly transposon IS861 associated.","Thu Mar 7 09:55:14 2002","","No significant hits to the NCBI PDB database.","SMU.1408c","Thu Nov 29 18:51:10 2001","Residues 55 to 148 (E-value = 5.3e-06) place SMu1284 in the Transposase_8 family which is described as Transposase (PF01527)","Thu Mar 7 09:55:14 2002","24379812","","","","","","1","","","SMU.1408c","" "SMu1285","1338651","1337785","867","ATGGTCCGTTTTATTTCAAATACCTTATCGCAAACTCTAAATGAACCCTTTCAGCAATCTCATAAATCTTGCAAACATCTTTATATTTTGGAAATTCTTTCGCAGGTGGTTATTGTTTCAGACCAAAAACAAGTCCCTTTACAACCTTATGATATTATCCTCGCTCAATCTTTTAATCACTTGCAGATAGACTCTCTAGATAGAAATCCCATTTTACTGCGTTTATATAGTCTTGATTTTGACCTACCGTCACCGCTCAATCAATATACTGTGGGCGACAATCCTCTCATTCATGATTTAATGAATGATCATACAAGTGAAGATGCTTATATTCTTTTTACAAATCTATCCGATTTAATTTGCCATGCCTATCTTGATGCCCTTGAAAAATTAGAAAATCTAAGAGACAATAATGATGAACAAGTCTATATTGATTTTCAAAGGCAAAAGCTAGCAGGTTTGTTATTTACGGAGCTCCTGCGTCAACATGATGCTAAAGTATCTAAATTTGCCTCTCGCTTTCCTTCAGTAAATGTTAAGTATGCTTCTAAGGATAGCCAATCAGGTGCTATTATGAAATACGTTTCAGATAATGTTCATCATATTAGCTTAAAAGAAGCGGCAGCTCATTTTTTTTATCAAGCCAATTATTTTTCAAGGCTCTGCCACGAGCTTTTTGGTATTTCTTTTAATCAATTAAAAACAACCATTCGTTTAGAAATTGCTAAAGAACAATTGCGACTGACAACTAAAAGTGTAGAAGAAATTAGCCAAGAATTAGGCTACAAAGCTGTTTCAAATTTTCATCGTAATTTTAAAAGTCAGACGGGCATGACACCAAATGATTATCGACAAGATAAACAATAG","6.60","-2.25","33367","MVRFISNTLSQTLNEPFQQSHKSCKHLYILEILSQVVIVSDQKQVPLQPYDIILAQSFNHLQIDSLDRNPILLRLYSLDFDLPSPLNQYTVGDNPLIHDLMNDHTSEDAYILFTNLSDLICHAYLDALEKLENLRDNNDEQVYIDFQRQKLAGLLFTELLRQHDAKVSKFASRFPSVNVKYASKDSQSGAIMKYVSDNVHHISLKEAAAHFFYQANYFSRLCHELFGISFNQLKTTIRLEIAKEQLRLTTKSVEEISQELGYKAVSNFHRNFKSQTGMTPNDYRQDKQ","1337800","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0891 (bglB); SMu0892 (bglB); SMu0893 (bglC); SMu0895 (bglA); SMu1007 (bglC); SMu1454 (bglG) and SMu1456 (bglA).","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulator:residues 184-285 are 25% similar to the previously published protein in S.mutans (gi|9622921|). Residues 180-285 are 37% similar to transcriptional regulator in B.halodurans (gi|15616404|).Residues 185-288 are 35% similar to the protein in B.subtilis (gi|16080067|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0432 (3e-10).","

InterPro
IPR000005
Domain

Helix-turn-helix, AraC type
PR00032	$\"[253-268]T$ $\"[268-284]T$	HTHARAC
PF00165	$\"[190-235]T$ $\"[241-285]T$	HTH_AraC
SM00342	$\"[201-284]T$	HTH_ARAC
PS00041	$\"[238-280]T$	HTH_ARAC_FAMILY_1
PS01124	$\"[189-286]T$	HTH_ARAC_FAMILY_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[184-232]T$ $\"[237-286]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[237-285]T$	Homeodomain-rel

noIPR
unintegrated

unintegrated
PTHR11019	$\"[235-286]T$	PTHR11019
PTHR11019:SF11	$\"[235-286]T$	PTHR11019:SF11

","BeTs to 5 clades of COG2207COG name: AraC-type DNA-binding domain-containing proteinsFunctional Class: KThe phylogenetic pattern of COG2207 is ------vCEBRH---------Number of proteins in this genome belonging to this COG is 3","***** IPB000005 (AraC type helix-turn-helix) with a combined E-value of 3.6e-11. IPB000005 253-284 IPB000005 203-234","Residues 192-285 are 36% similar to a (TRANSCRIPTION DNA-BINDING REGULATION) protein domain (PD402035) which is seen in Q9K2K0_BACCE.Residues 194-284 are 41% similar to a (DNA-BINDING TRANSCRIPTION REGULATION TRANSCRIPTIONAL) protein domain (PD385094) which is seen in Q9K690_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Oct 26 16:45:14 2002","Thu Mar 7 09:58:31 2002","Fri Oct 18 08:42:08 2002","Thu Mar 7 09:58:31 2002","Thu Mar 7 09:58:31 2002","Thu Mar 7 09:58:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1285 is paralogously related (blast p-value < 1e-3) to SMu0893, a predicted transcriptional regulator.","Thu Mar 7 09:58:31 2002","","No significant hits to the NCBI PDB database.","SMU.1409c","","Residues 241 to 285 (E-value = 9e-10) place SMu1285 in the HTH_AraC family which is described as Bacterial regulatory helix-turn-helix proteins, araC family (PF00165)","Thu Mar 7 09:58:31 2002","24379813","","Cote CK, Honeyman AL. The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549 ","","Sat Oct 26 16:45:14 2002","","1","","","SMU.1409c","" "SMu1286","1338776","1340209","1434","ATGGAAAAAGAATACAAAGTTGATGTCGTCGTTGCTGGAGCTGGCGGTGCTGGTTTAGCTGCTGCTCATGCTGCCGCTCAAAATGGACTTAAAGTCTTGGTTCTCGAAAAATTAAAACAAATTGGTGGGAATACTAGAATTTCCTCAGGTTTTTTTGCCATTAACACTAAAGAGCAAAACGCTGCAGGTTTAAAGCTTTCTACGCAAGAAGCCATCAGACAACTGCAAGAACATAATCATTTTCTAAGTAATGGTGCTTTGTTAAAAAACATCATCGAACATGCTAAAGAAACTTTAGAGGAAATTGAAAAATTGGGAATGGAAATTAAGCTCAATCCAACTAAGAATTCTACTCAATTTGCACATTTTGGTAATGATTACCAAGGTGGTTCTTATCACATGTATATGAATAAGGACTCTAGTTATCTGCAAATTCAAAAATCGTTGGAAGCAATGGGAGTAACCTTTATCTTTGGTGTCAGAATGACGGAACTCCTTCAAGATTCTAATGGACATGTCCGTGGTTTGAAAGCTCTCAATGATGCAGGAGAAAGTATGACAGTGCATGCTAAAGCTAGCATTATTACTACAGGTGGCTTTGGCGGTGATAAAAGACGTGTAGCCAAGGTTATGCGAACTTTAAATCTTCGCACTTTAGGTGTTCCTAATATGGGAGAAGGCTTGTCAGCTATGGAAGCTGCTGGAGGAGTTAATATTGATGGATCAGCTCTTATTCATGCAGCGCAAATGGCTCAATCCACTGTTACCCAAGAAACCAAAGGCAAGCAATTAGCGGGCTTTAATGATTCACCTCTAACACAACTTTTGCTTTCACCTTTGCTTTGGGTAGATCCAAATGGTTCTCGTTTTACCAATGAAGATGTCGTTTATGATACGGTTCAATGGGCCAACGCTGCCTATGGTGTAGGTAGTAAATATTACTATGTCATGGACACAGCAACACTTGAAAGTTATACGAAGCAGCCACTGCTTACTATTTCCAAATCCGGACCGGGTGCTTCTCAGGCTAAGGGAGATTTTGTAAGCTTAGCTGAGCAAGCAGTCCAACAAGGCATCGCTTTTAAAGGAGACAGTCTTGAAGAGCTAGCTCAGAATTCCGGAATGGATCCTATCGCTTTTAAGGCAACCGTGGCAGAATACAACAAGGCCATTGCAAGCCAAAACGATGAAATATTCAGTAAATCTGCATCATCACTTAAATATGATGTCAAGAAAGGACCATTTTATGCTTTTATCGCTCAAGTGATTTATTTAGGAACAGTTGGCGGTGTCCGTGTTGATAAAGATCTTCGCGTTCTTGATGCTTATATGAAAGCAATTCCTGGACTTTATACTGGCGGAGCTAATGCTGGTGGTTATTATGCCCCTCGCAATTATCCTGCTTATGAAGGTTTAGCTTCAGGCTTCTCATAG","7.40","1.19","51128","MEKEYKVDVVVAGAGGAGLAAAHAAAQNGLKVLVLEKLKQIGGNTRISSGFFAINTKEQNAAGLKLSTQEAIRQLQEHNHFLSNGALLKNIIEHAKETLEEIEKLGMEIKLNPTKNSTQFAHFGNDYQGGSYHMYMNKDSSYLQIQKSLEAMGVTFIFGVRMTELLQDSNGHVRGLKALNDAGESMTVHAKASIITTGGFGGDKRRVAKVMRTLNLRTLGVPNMGEGLSAMEAAGGVNIDGSALIHAAQMAQSTVTQETKGKQLAGFNDSPLTQLLLSPLLWVDPNGSRFTNEDVVYDTVQWANAAYGVGSKYYYVMDTATLESYTKQPLLTISKSGPGASQAKGDFVSLAEQAVQQGIAFKGDSLEELAQNSGMDPIAFKATVAEYNKAIASQNDEIFSKSASSLKYDVKKGPFYAFIAQVIYLGTVGGVRVDKDLRVLDAYMKAIPGLYTGGANAGGYYAPRNYPAYEGLASGFS","1340218","","fumarate reductase","Extracellular","Weak similarities in gapped BLAST to Chain A,flavocytochrome C3 sequences. Residues 28-448 are 24% similar to gi|6573457|, a predicted Chain A, Flavocytochrome C3 in Shewanella Frigidimarina and residues 29-440 are 22% similar to gi|15673106|,from Lactococcus lactisSMu1286 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003953
Domain

Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal
PF00890	$\"[8-472]T$	FAD_binding_2

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[2-317]T$	G3DSA:3.50.50.60
PTHR11632	$\"[4-240]T$	PTHR11632
SSF51905	$\"[1-461]T$	SSF51905
SSF56425	$\"[275-431]T$	SSF56425

","BeTs to 3 clades of COG1053COG name: Succinate dehydrogenase/fumarate reductase, flavoprotein subunitsFunctional Class: CThe phylogenetic pattern of COG1053 is Amt-YqvcEbRhuj----inxNumber of proteins in this genome belonging to this COG is 2","***** IPB000171 (Bacterial-type phytoene dehydrogenase) with a combined E-value of 2.1e-07. IPB000171A 10-40***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 2.6e-07. PR00368A 8-30 PR00368C 8-33***** IPB000447 (FAD-dependent glycerol-3-phosphate dehydrogenase) with a combined E-value of 7.3e-07. IPB000447A 7-59 IPB000447C 182-204***** IPB003952 (Fumarate reductase / succinate dehydrogenase FAD-binding site) with a combined E-value of 7e-06. IPB003952A 8-22","Residues 364-448 are 36% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD009971) which is seen in O24819_RHORH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 10:15:31 2002","Thu Mar 7 10:12:02 2002","Fri Oct 18 08:37:25 2002","Thu Mar 7 10:12:02 2002","Thu Mar 7 10:12:02 2002","Thu Mar 7 10:12:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1286 is paralogously related (blast p-value < 1e-3) to SMu0162, and SMu0762, both predicted reductases; SMu1299, a predicted dihydrolipoamide dehydrogenase.","Thu Mar 7 10:15:31 2002","Thu Mar 7 10:12:02 2002","pdb|1E39|A Chain A, Flavocytochrome C3 From Shewanella Frigidim... 97 4e-021pdb|1QJD|A Chain A, Flavocytochrome C3 From Shewanella Frigidim... 96 7e-021pdb|1QO8|A Chain A, The Structure Of The Open Conformation Of A... 68 3e-012","SMU.1410","","No significant hits to the Pfam 11.0 database","Thu Mar 7 10:12:02 2002","24379814","","","","","","1","","","SMU.1410","" "SMu1287","1340276","1341451","1176","ATGAATCAAAAAAATCTCAGTCCAAGTTCTTGGCTTTTTAAAATTTCAGTCTTGTCTCTATCCATTCTAGCCATGACAGCTCCTTCGATTTCTATTGCCAATAATCTGTTGCAAAAGACTTTTACTCAACAGTCAACAGCAGAAATTGAGATGATTTCAACTCTTCCAAATTTCGGAGTGCTTCTGCTCATTCTCTTTGCAGATACGATTGCTAATAAATTTGGTATTAAACGTACTATTACGGCTGGTTTGTTGATGTACCTTTTAGGTGGTGTTTTACCTTCTTTTATTCCTAATTATTATGCTATTGTCTTCTTACGTTTCCTTATGGGCTGTGGAATTGGTTTATTTAATCCTTTTTCAGTTAGTTTAATGTATCGTTTTTATAAAGACCAAGAATTATCCGATATGTTAGGATTTCAAAATACTGGTCAAAATCTTGGAAATGCTGGTTTTGGTTTCTTATTAGGAGCCTTGGTATTAGCTGGTTGGAAAGTTGCCTTTATGGGATATTTTATTGCTCTTATTCCGCTTATTCTCTTCGGCGCTTTTGTTGTTATTCCTGACGATCAACCAACTATTAAAAAAGAAAGACCAAAATTGGCGGATTCTATTAATGGACATATCCTTCTCTTGGCCTTGCTTTTTCTCATTATCTTTGGCATGTTTATGATGATGACCATTAAGATGGCACTTTTTGGAGCTGAAACTGGCCTCATTTCTGCTTCAGCAGCCTCTTCTATTCTTGCAGTATTAGGGCTATCATCTATGTTTTCAGCTATTGCCTTTGGAAAATTAAGTAAGCGCGTTGGTAATTTTATGCTACCCATCTCATTGACAGGTATAGCTATGGGCTTCTTCATTGTTGCCAGTGCCAGTAATGCAGCTATGGTTGTTTTTGGAGTTATTATTGCTGGAATTTTCTTTGGTTGGGTTTTTCCACAAGCTTTTCTCCGAGCAGCACAGGTTGGCCCCAAAGAGGGTGGAACATTGACAACTTCAGTTATCCTAATGGGAATCAATCTAGGTGCCTTTCTTTCTCCTTCAATTGTTAATTTTGTTGCTAATCTTTTAGGAAATAAAACGGCTGCATCAGTTTTAGCAATGTGTGGCTGGGGCTTTGCTCTTTTGGCTATATTAGAATACCTTTATACGTTCTTCAACCAAAGAACGTAA","10.40","9.13","42092","MNQKNLSPSSWLFKISVLSLSILAMTAPSISIANNLLQKTFTQQSTAEIEMISTLPNFGVLLLILFADTIANKFGIKRTITAGLLMYLLGGVLPSFIPNYYAIVFLRFLMGCGIGLFNPFSVSLMYRFYKDQELSDMLGFQNTGQNLGNAGFGFLLGALVLAGWKVAFMGYFIALIPLILFGAFVVIPDDQPTIKKERPKLADSINGHILLLALLFLIIFGMFMMMTIKMALFGAETGLISASAASSILAVLGLSSMFSAIAFGKLSKRVGNFMLPISLTGIAMGFFIVASASNAAMVVFGVIIAGIFFGWVFPQAFLRAAQVGPKEGGTLTTSVILMGINLGAFLSPSIVNFVANLLGNKTAASVLAMCGWGFALLAILEYLYTFFNQRT","1341460","","conserved hypothetical protein","Membrane, Extracellular","Matches in gapped BLAST to hypotheticals and different kinds of proteins:residues 11-383 are 22% similar to hypothetical protein from S.pneumoniae (gi|15901440|).Residues 15-142 are 30% similar to bicyclomycin resistance protein from Rickettsia conorii (gi|15892998|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1892 (4e-21).","

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[12-391]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[12-356]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[10-390]T$	PTHR10074
SSF103473	$\"[1-381]T$	SSF103473

","BeTs to 11 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","***** IPB002897 (Monocarboxylate transporter) with a combined E-value of 2.2e-08. IPB002897B 58-112 IPB002897C 138-163 IPB002897D 212-264 IPB002897E 318-369","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 7 10:46:56 2002","Thu Mar 7 10:46:56 2002","Thu Mar 7 10:46:56 2002","Thu Mar 7 10:46:56 2002","Thu Mar 7 10:46:56 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1287 is paralogously related (blast p-value < 1e-3) to SMu0130, SMu1465, SMu1173, SMu0677, SMu1460, and SMu1914, hypotheticals and predicted permeases. ","Thu Mar 7 10:46:56 2002","","No significant hits to the NCBI PDB database.","SMU.1411","","No significant hits to the Pfam 11.0 database","Thu Mar 7 10:46:56 2002","24379815","","","","","","1","","","SMU.1411","" "SMu1288","1344155","1341627","2529","ATGTTAGAGTTAAAGCATATTACTAAAGTATATGAAACTGCGGGTATTAAGCGAATGGCTTTGGAAAATGTTAGTGTCAACTTTCGTGCCAATGAATTTGTTGCGGTTTTAGGGCAGTCCGGCTCAGGGAAAACGACCTTGCTTAATATTATTGGCGGTTTGGATCAATACACGACTGGTGATTTATTAATCAACGGAAAATCGACCAAAGATTTTAAAGACAAAGACTGGGACAGCTATCGCAATAATACTATTGGTTTTGTTTTTCAGTCTTATAATCTCATTTCGCATCAAACAGCGCTGGCTAATGTTGAATTAGCCCTAACCCTATCAGGTGTTTCAAAAGCTGAACGCCGAAAACGTGCTTTGGATGCTTTGAAGCGGGTTGGTTTGGAAGATGAGATTAATAAAAAGCCCAACCAAATGTCAGGTGGTCAGATGCAGCGGGTTGCGATTGCGCGTGCCTTAGTTAATAATCCTGATATCTTACTGGCTGATGAACCAACAGGGGCTTTAGACTCAGAAACATCCTTGCAGATTATGGATTTGCTAAAGGAAATTGCTCAAGAGCGTTTAGTCATTATGGTAACTCATAATCCCGATTTAGCAGAAAAATATTCTAATCGCATTATCAAGGTTCTTGATGGTCATATTATTAATGACAGCAATCCATATACTGACGATGAGATCAGAAAAGCAACTGTTGATTTTAAAAAGACTAAAATGTCTTTTACAACAGCTCTTTCGCTTTCTTTTAATAATTTATTGACCAAGAAGGGACGAACCTTGCTAACTGCCTTTGCAGGATCTATTGGGATCATTGGGATTGCTTTGATCTTATCGCTGTCAAATGGTGTGCAAAAATATATTGCTAAAACGCAAGAAGATACGCTGGTTGCTTATCCTTTATCTATCGAAAAGTCTTCCAATAAAAATTTTATCGGACTTCTTGCAGCTAATAGTAATGAAAACAAGAAGTCTGATAAGAAAAAGACAAACAAGAAGATTGGAACCAATAGTATCCTAAAGAATATGATTTCAACGCAGGTCGTTGATAATGATTTGGCTTCATTTAAAACTTATATCAAAAAACATCAAAAGAAATTTGCTGCTGTTACCAAAGATATTCAATATTCTTATAAAATAACACCTCGAATTTATCAGTCTGATACTTCAAAAGGAGTCAAAGCTGTCAATCCTAATACTTTAAGCAAAGATCTGAAAGATACCAGCACAAGTATTCAAACAGTCGTTTCTAACCTTGATATTTGGCAAGAATTATCTTCTAATGAAAAAATGCTGTCTTCACAATATCAAGTTATTTCAGGGCATTTGCCAAAGCAATATAATGAAGTTGTGCTTATGGCTGATGAAAACAACAAAATTGATGATTATGTTCTTTACAGTTTGGGAATTAAAGATGCCAAGCAATTAAATAGCAAAACGATTAAAAAAGTCAAAGCCAGCAGTTACCATTATAAAGATTTGATTGGCAGAACTTACAAGCTCGTTATCAATTCTGATCTTTACCAAAAAGAAGGTAATGCTTGGATTGATCGTTCTGATAATGATGCTTACATGAAGCAAGTCATCAATGCTGCTGAAAATATTAAGATTGTTGGTATTGTCAAACCACAAGAAGGAACAACAAGCGAAAGTTCCAGTGCCGGTGTTGGTTACAGCCATGATTTAACTGATTATCTTGCTAAAAAAATCAAGAGCAGCACTATTGCCAAAGAGCAGCTGGCTAATAAGAAATTGAATGTCTTTACCGGTCAATCCTTTTCAAGCGGTAACAAAACTTTCTCCTCAGACAATTTGAGTGTTCAGCAGCAAGCTAGTATGGCTTCGATGTCAGCTGAAGAATTAGCTGATTATGTCAATCGTTACAATGAAAATGCCAATGCAACTTATAAAGATAACTTGGAAAAAATTGGTATCATTGATAACAATAATCCAGAAACCATCCATTTTTATGCCTCTTCTTTCAAAGATAAGGAAGCTCTGAAGGATTTAATCAGTGACTATAATAAAAAAGTCAAAAAGGATAAGCATAAGTCTAGAGTAATTCGTTATACAGATACAGTTGGTTTGATGATGTCATCAGTAACAACAATGATTAATGCCGTCACCTATATTTTAATTGGTTTTGTTGCTATTTCCTTGATTGTATCGTCTATTATGATTGGTATTATTACCTATATCTCTGTTTTAGAACGCACCAAGGAAATTGGTGTTTTGCGTGCTATGGGGGCTTCTAAGAGGGATGTAACCCGTATTTTTACAGCAGAGACCATTATTGAAGGTGCTATCGCTGGAGTACTTGGAATCTTGATTACCCTTTTACTAAATATTGCGATTACACTTATTGTGAAAAATTGGCTGAATATCAATCATATCTCTTCCCTACCTATTTGGTCAGCAATTGTTCTCATTGCTATTTCTATCGTACTCACTGTCTTTGCAGGTATTCTGCCATCACGTGTAGCAGCTAAAAAAGATCCCGTCGAAGCCTTACGGACAGAATAA","10.20","23.71","93212","MLELKHITKVYETAGIKRMALENVSVNFRANEFVAVLGQSGSGKTTLLNIIGGLDQYTTGDLLINGKSTKDFKDKDWDSYRNNTIGFVFQSYNLISHQTALANVELALTLSGVSKAERRKRALDALKRVGLEDEINKKPNQMSGGQMQRVAIARALVNNPDILLADEPTGALDSETSLQIMDLLKEIAQERLVIMVTHNPDLAEKYSNRIIKVLDGHIINDSNPYTDDEIRKATVDFKKTKMSFTTALSLSFNNLLTKKGRTLLTAFAGSIGIIGIALILSLSNGVQKYIAKTQEDTLVAYPLSIEKSSNKNFIGLLAANSNENKKSDKKKTNKKIGTNSILKNMISTQVVDNDLASFKTYIKKHQKKFAAVTKDIQYSYKITPRIYQSDTSKGVKAVNPNTLSKDLKDTSTSIQTVVSNLDIWQELSSNEKMLSSQYQVISGHLPKQYNEVVLMADENNKIDDYVLYSLGIKDAKQLNSKTIKKVKASSYHYKDLIGRTYKLVINSDLYQKEGNAWIDRSDNDAYMKQVINAAENIKIVGIVKPQEGTTSESSSAGVGYSHDLTDYLAKKIKSSTIAKEQLANKKLNVFTGQSFSSGNKTFSSDNLSVQQQASMASMSAEELADYVNRYNENANATYKDNLEKIGIIDNNNPETIHFYASSFKDKEALKDLISDYNKKVKKDKHKSRVIRYTDTVGLMMSSVTTMINAVTYILIGFVAISLIVSSIMIGIITYISVLERTKEIGVLRAMGASKRDVTRIFTAETIIEGAIAGVLGILITLLLNIAITLIVKNWLNINHISSLPIWSAIVLIAISIVLTVFAGILPSRVAAKKDPVEALRTE","1341642","SMu1288 also has NBD1.","ABC transporter, ATP-binding and permease fusion protein","Membrane, Cytoplasm","This sequence corresponds to the previously sequenced gi|4098079| gi|4098079|,gi|4098078|,and gi|15625442|,in GenBank, predicted as ABC transporter membrane protein subunit.Matches in gapped BLAST to ABC transporter,ATP-binding proteins: residues 1-247 are 44% similar to gi|15672696| from L.lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1360 (2e-51).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[141-184]T$	ABC_transporter
PF00005	$\"[31-216]T$	ABC_tran
PS00211	$\"[142-156]T$	ABC_TRANSPORTER_1
PS50893	$\"[2-240]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-217]T$	AAA

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[653-835]T$	FtsX

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-233]T$	G3DSA:3.40.50.300
PTHR19222	$\"[2-221]T$	PTHR19222
PTHR19222:SF32	$\"[2-221]T$	PTHR19222:SF32
SSF52540	$\"[1-226]T$	SSF52540
SSF90123	$\"[324-825]T$	SSF90123

","BeTs to 14 clades of COG1136COG name: ABC-type (unclassified) transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1136 is AMt--QVCEBRHUJGPOLinxNumber of proteins in this genome belonging to this COG is 8","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.3e-35. IPB001140A 20-66 IPB001140B 139-177***** IPB003838 (DUF214) with a combined E-value of 6.9e-24. IPB003838A 729-776 IPB003838B 826-839","Residues 85-213 are 27% similar to a (AS-48D PLASMID BACE) protein domain (PD034066) which is seen in O52967_ENTFA.Residues 792-840 are 97% similar to a (TRANSMEMBRANE PROTEOME COMPLETE SYSTEM) protein domain (PD405713) which is seen in Q9ZAX7_STRMU.Residues 122-201 are 34% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 32-228 are 26% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 80-115 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230) which is seen in Q9ZAX8_STRMU.Residues 122-204 are 34% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD033004) which is seen in O59176_PYRHO.Residues 185-341 are 77% similar to a (BINDING ATP-BINDING SUBUNIT ABC) protein domain (PD200712) which is seen in Q9ZAX8_STRMU.Residues 706-755 are 98% similar to a (PROTEOME COMPLETE MEMBRANE TRANSMEMBRANE) protein domain (PD003665) which is seen in Q9ZAX7_STRMU.Residues 86-139 are 46% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9RUM8_DEIRA.Residues 21-67 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9ZAX8_STRMU.Residues 141-184 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9ZAX8_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:04:51 2002","Wed Oct 23 15:27:14 2002","Fri Oct 18 08:30:40 2002","Thu Mar 7 10:58:55 2002","Thu Mar 7 10:58:55 2002","Thu Mar 7 10:58:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1288 is paralogously related (blast p-value < 1e-3) to SMu0786, SMu1246, SMu1231, SMu1068, SMu1751, SMu0916, SMu0731, SMu1210, SMu0849, SMu1762, SMu1380, SMu0218, SMu1001, SMu0517, SMu1920, SMu0884, SMu0971, SMu1079, SMu0594, SMu0234, SMu1949, SMu0418, SMu1428, SMu1003, SMu0805, SMu1950, SMu1757, SMu1036, SMu0907, SMu1023, SMu0235, SMu1316, SMu1064, SMu0475, SMu1037, SMu0335, SMu0596, SMu0216, SMu0390, SMu0944, SMu1518, SMu0950, SMu0836, SMu0986, SMu0824, SMu0374, SMu1649, SMu0823, SMu1517, SMu1811, SMu0825, SMu0476, SMu1724, SMu0024, SMu1065, SMu1710, SMu0164, SMu1410, SMu0787, SMu0258, SMu0987, SMu1959, SMu0976, SMu1093, SMu0752, SMu0837, SMu0666, SMu1306, SMu1752, SMu1545, SMu1050, SMu1202, SMu0729, SMu0224, SMu1067, SMu0917, and SMu1686, all with ATP-binding capabilities.","Fri Mar 22 08:20:55 2002","Thu Mar 7 10:58:55 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 140 7e-034pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 118 3e-027","SMU.1412c","","Residues 31 to 216 (E-value = 2.2e-63) place SMu1288 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 653 to 835 (E-value = 5.1e-44) place SMu1288 in the FtsX family which is described as Predicted permease (PF02687)","Thu Mar 7 10:58:55 2002","24379816","","","","Mon Oct 28 11:04:51 2002","","1","","","SMU.1412c","" "SMu1289","1344909","1344250","660","ATGAAAGATAAGTTTCACTTTATTTTTAGCCTTCTTTTTTTGCTGGCTTTTTCAGTTCTTGCCACCATTTATTTAGTCTGGCTTTTTTATCCTTTAGAGATATCTTTGTTGGGTTTGGAAAAAGTGGTTTATATGAAAAGCGGTCAGATTCAGGATAATTTCAATCGTTTAATGCTTTATTTGACCAGTCCTTTTCATTGGCAGCTGGTTATGCCTGATTTTCCTTCTTCCAAAGATGGTTTGCACCATTTTGAGCAAGTGAAATGGCTTTTTCATTTAGCACAAATCTGTTTTCTTTTAACCCTGCCTAGTTTTCTTTTTTTTATGAAAAATGTCGTTCAAAAAGGTTATGGTGTCTTGTATCAACGATCTCTAAAGTTTACAGCACTTATCCCTCTTATTTTGACTCTAATCGCTGTGGGAATAGGTTTTGATAGTTTTTTCACACTTTTTCATCAAGTCCTTTTTGCAGGGGATGAGACTTGGCTTTTTAACCCAAACACAGACTCTGTTATCTATATTTTTCCTGAAGCCTTCTTTTTACACTGCTTTTTGCTTTTTCTGATTCTTTATGAGGTTTCATTTTGCAGCCTTTTGTGGCAGATTAGAAGGAAAAACAAAGAGAACAGAGGCAGTACAGAAGAGACAAACCGGTTCTGA","8.00","2.53","25892","MKDKFHFIFSLLFLLAFSVLATIYLVWLFYPLEISLLGLEKVVYMKSGQIQDNFNRLMLYLTSPFHWQLVMPDFPSSKDGLHHFEQVKWLFHLAQICFLLTLPSFLFFMKNVVQKGYGVLYQRSLKFTALIPLILTLIAVGIGFDSFFTLFHQVLFAGDETWLFNPNTDSVIYIFPEAFFLHCFLLFLILYEVSFCSLLWQIRRKNKENRGSTEETNRF","1344265","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypothetical protein: residues 22-205 are 50% similar to the protein in S.pneumoniae (gi|15903306|) and are 44% similar to the protein from S.pyogenes (gi|15902045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0893 (1e-39).","

InterPro
IPR010178
Family

Integral membrane protein 1906
PF07314	$\"[1-180]T$	DUF1461
TIGR01906	$\"[1-208]T$	integ_TIGR01906

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-195 are 33% similar to a (PROTEOME COMPLETE) protein domain (PD400269) which is seen in Q9CGF2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 22 08:24:37 2002","Fri Mar 22 08:24:37 2002","Thu Mar 7 11:19:55 2002","Thu Mar 7 11:19:55 2002","","Thu Mar 7 11:19:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1289 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 11:19:55 2002","","No significant hits to the NCBI PDB database.","SMU.1414c","","Residues 1 to 180 (E-value = 5.5e-105) place SMu1289 in the DUF1461 family which is described as Protein of unknown function (DUF1461) (PF07314)","Thu Mar 7 11:19:55 2002","24379817","","","","","","1","","","SMU.1414c","793" "SMu1290","1345672","1344899","774","ATGACATACAAGGGTTATCTTATTGACCTTGATGGGACCATCTATAAAGGAAAAGACAGAATTCCTGCTGGAGAAGATTTTGTTAAACGATTGCAGGAAAGACAGCTTCCCTATATTTTAGTGACTAATAATACAACACGTACGCCCGAAATGGTTCAAGAAATGCTAGCAACCTCTTTTAATATCAAAACGCCACTTGAAACTATTTACACAGCGACATTAGCGACTATTGATTATATGAACGATATGAAACGTGGGAAAACAGCTTATGTCATTGGTGAAACAGGACTTAAAAAGGCTGTTGCTGAAGCGGGGTATCGTGAAGATAGTGAGAATCCTGCTTATGTAGTGGTTGGTTTAGATACGAATTTGACTTATGAAAAGCTAACTCTGGCAACTTTGGCCATTCAAAAAGGAGCTGTTTTTATTGGAACAAATCCTGATCTTAATATTCCAACAGAGCGCGGCTTATTGCCGGGAGCGGGGGCTATTTTATTTCTTTTGGAAAAAGCAACACGTGTCAAGCCTATTATTATTGGTAAGCCTGAAGCTGTTATCATGAATAAAGCTTTAGATCGTCTGGGCGTCAAACGCCATGAAGCGATAATGGTTGGCGATAATTATCTGACAGATATTACTGCTGGCATTAAAAATGATATTGCAACGCTTTTGGTGACGACAGGTTTCACCAAACCAGAAGAAGTACCTGCTTTGCCAATTCAGCCTGATTTTGTTTTATCCAGTCTTGCGGAGTGGGATTTCGATGAAAGATAA","5.00","-4.75","28374","MTYKGYLIDLDGTIYKGKDRIPAGEDFVKRLQERQLPYILVTNNTTRTPEMVQEMLATSFNIKTPLETIYTATLATIDYMNDMKRGKTAYVIGETGLKKAVAEAGYREDSENPAYVVVGLDTNLTYEKLTLATLAIQKGAVFIGTNPDLNIPTERGLLPGAGAILFLLEKATRVKPIIIGKPEAVIMNKALDRLGVKRHEAIMVGDNYLTDITAGIKNDIATLLVTTGFTKPEEVPALPIQPDFVLSSLAEWDFDER","1344914","For other 'nag' genes see SMu0578 (nagB).","N-acetylglucosamine catabolic protein","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins and to N-acetylglucosamine. Residues 1-252 are 78% similar to gi15675039 from S.pyogenes and residues 1-256 are 74% similar to gi15903307 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0892 (1e-112).","

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[3-228]T$	Hydrolase

InterPro
IPR006354
Family

HAD-superfamily hydrolase, subfamily IIA, hypothetical 1
TIGR01457	$\"[3-252]T$	HAD-SF-IIA-hyp2

InterPro
IPR006357
Family

HAD-superfamily hydrolase, subfamily IIA
TIGR01460	$\"[6-228]T$	HAD-SF-IIA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[3-252]T$	G3DSA:3.40.50.1000
PTHR19288	$\"[2-252]T$	PTHR19288
PTHR19288:SF3	$\"[2-252]T$	PTHR19288:SF3
SSF56784	$\"[1-252]T$	SSF56784

","BeTs to 9 clades of COG0647COG name: Predicted sugar phosphatases of the HAD superfamilyFunctional Class: GThe phylogenetic pattern of COG0647 is a--kYqv-eBR---------xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 9-146 are 71% similar to a (PROTEOME COMPLETE) protein domain (PD005233) which is seen in Q9CGF3_LACLA.Residues 148-235 are 64% similar to a (COMPLETE PROTEOME) protein domain (PD202150) which is seen in Q9CGF3_LACLA.Residues 6-146 are 28% similar to a (PROTEOME COMPLETE NAGD CJ0315) protein domain (PD355291) which is seen in Q9X264_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 15:57:28 2006","Tue Oct 29 08:18:06 2002","Mon Sep 11 15:57:28 2006","Thu Mar 7 15:11:42 2002","","Thu Mar 7 15:11:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1290 is paralogously related (blast p-value < 1e-3) to SMu1640, a predicted conserved hypothetical protein.","Thu Mar 7 15:18:52 2002","","No significant hits to the NCBI PDB database.","SMU.1415c","","Residues 3 to 228 (E-value = 1.9e-19) place SMu1290 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Thu Mar 7 15:11:42 2002","24379818","","","","","","1","","","SMU.1415c","341" "SMu1291","1346304","1345687","618","ATGCAAGAGAAGAAATGGTTGGATTGGCTGATTCGTTTGCAGTCATTGGCACAAGCGGGTCTGGCCTATGGTAAGGATAAATATGATATTGAGCGATTTGAAGAGATTCGAGATCTCTCTGTGCAAATGCTAACGGCTCTTTCTGATTTGCCAGCTCAAAAAGTTGAAAATCTCTTTGCTAGTGAGACCGGCTATCAAACACCAAAGATTGATACCCGTGCCGCTATTTTTAAAGAAAATAAAATCCTGCTCGTCCAAGAGGCCAATGGCACTTGGGCGTTGCCGGGAGGGTGGTGTGATGTTGATCAGTCTGTCAAGGAAAATACTATCAAAGAAGTTAAGGAAGAAGCAGGTTTAAATGTTGTCTTAGATAAAGTAATAGCAGTACAAGATAGAGATAAACATAACCAACCGCCTTATGCTTATAAAATTTGTAAAATTTTTTCACTCTGTCATGCAACTGGTGGCGCTTTTACTAAAAATCTTGAGACCATTGCTAGTGACTATTTTGAACGAGATCAATTGCCAACATTAGCTCAAGCTAAGACCAATGAAGACCAAATTCAAATGTGCTTTGCCGCTTATGAAAATGATGATTGGAAAACTGTAATAGATTAA","4.70","-8.70","23326","MQEKKWLDWLIRLQSLAQAGLAYGKDKYDIERFEEIRDLSVQMLTALSDLPAQKVENLFASETGYQTPKIDTRAAIFKENKILLVQEANGTWALPGGWCDVDQSVKENTIKEVKEEAGLNVVLDKVIAVQDRDKHNQPPYAYKICKIFSLCHATGGAFTKNLETIASDYFERDQLPTLAQAKTNEDQIQMCFAAYENDDWKTVID","1345702","For other 'mut' genes associated with repair and DNA mutation, see Smu0510; SMu0024 (mutT); SMu1697 (mutY);SMu1700 (mutS2);SMu1291 (mutT); SMu1325 (mutX); SMu1371 (mutR); SMu1468 (mutM); SMu0824 (mutT) and SMu0825 (mutT).","mutator protein MutT","Cytoplasm","Significant matches in gapped BLAST to mutator MutT and to hypothetical proteins: residues 3-205 are 46% similar to the protein from B.halodurans (gi15615651).Residues 39-205 are 38% similar to gi16078284 from B.subtilis (gi16078284).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0487 (9e-05).","

InterPro
IPR000086
Domain

NUDIX hydrolase
PR00502	$\"[92-106]T$ $\"[106-121]T$	NUDIXFAMILY
G3DSA:3.90.79.10	$\"[72-178]T$	NUDIX_hydrolase
PF00293	$\"[68-194]T$	NUDIX

InterPro
IPR015797
Domain

NUDIX
SSF55811	$\"[1-205]T$	NUDIX_hydrolase

noIPR
unintegrated

unintegrated
PTHR22769	$\"[72-181]T$	PTHR22769

","BeTs to 4 clades of COG0494COG name: NTP pyrophosphohydrolases (MutT family) including oxidative damage repair enzymesFunctional Class: L,RThe phylogenetic pattern of COG0494 is a-T-YqvCEBRHuj---linxNumber of proteins in this genome belonging to this COG is 6","***** IPB000086 (NUDIX hydrolase) with a combined E-value of 1.2e-06. IPB000086 92-118","Residues 15-76 are 40% similar to a (PROTEOME COMPLETE PA0990) protein domain (PD267255) which is seen in Q9I4X9_PSEAE.Residues 8-65 are 44% similar to a (PROTEOME COMPLETE MUTT PLASMID) protein domain (PD197725) which is seen in Q9K8B7_BACHD.Residues 76-129 are 58% similar to a (COMPLETE PROTEOME HYDROLASE MUTATOR MUTT/NUDIX FAMILY) protein domain (PD000653) which is seen in Q9K8B7_BACHD.Residues 131-205 are 34% similar to a (PROTEOME COMPLETE MUTT PA0990) protein domain (PD063286) which is seen in Q9K8B7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:06:04 2005","Thu May 2 11:27:29 2002","Tue May 3 12:06:04 2005","Thu Mar 7 15:28:20 2002","Thu Mar 7 15:28:20 2002","Thu Mar 7 15:28:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1291 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 15:28:20 2002","","No significant hits to the NCBI PDB database.","SMU.1416c","","Residues 68 to 194 (E-value = 8.8e-13) place SMu1291 in the NUDIX family which is described as NUDIX domain (PF00293)","Thu Mar 7 15:28:20 2002","24379819","","","","","","1","","","SMU.1416c","" "SMu1292","1347053","1346325","729","ATGGGGAAAAAATTTAAAACACGTTATCAAATACCTTTTTATGAAAGTGATGTCAATCATAATGTTAAGCTGCCTCACATTTTGTCAGTTGCCTTACAGATTGCTAGCGATCAGTCTGTTAGTTTAGGTTTGGGAGATGAGCGCATTTTTAAAGATTATAATTTAGTCTGGGTTGTCTCAGAACACGAGGTGACCATTGACCGCTTACCACGTTTTAATGAAATTGTGGAGATTGAAACAGAGCCAATTTCATACAATCGTTATTTTTGTTATCGTGAGTTCCGCATTTACGATCAAAATGGTGAAAAGCTTGTAGATATTTTTTCAACCTTTGTTCTTATGGATTATGATACGCGCAGGGTGCATGATGTCCCAGAAGATTTGGTTGCTCCTTATGAGTCTGAGAAAATCAGAAAAATTTTAAGGGGGCCAAAGTATAAAGCTTTGGAAAAAGCGACTGACACGCTTTATCATGTTCGATATTTTGACCTTGATATTAATGGACATGTCAACAACAGCCGTTATCTTGAATGGATGTATGATGTCCTTGATTTTAATTTTTTAAAAGCATATACTCCGAAAAAAATTAACCTCAAGTATGTCAAAGAGGTGCAATATGGCAGTGACATTGAATCACGTTTGGAACAAGATGGCTTAATCACCAAGCATGAGATTACTTCAAACGGGTACGTTAATGCACAAGCCATTACGCAGTGGGAAAAAATATAA","6.00","-4.35","28730","MGKKFKTRYQIPFYESDVNHNVKLPHILSVALQIASDQSVSLGLGDERIFKDYNLVWVVSEHEVTIDRLPRFNEIVEIETEPISYNRYFCYREFRIYDQNGEKLVDIFSTFVLMDYDTRRVHDVPEDLVAPYESEKIRKILRGPKYKALEKATDTLYHVRYFDLDINGHVNNSRYLEWMYDVLDFNFLKAYTPKKINLKYVKEVQYGSDIESRLEQDGLITKHEITSNGYVNAQAITQWEKI","1346340","For other 'fat' genes see SMu0908 (fatB).","acyl-ACP thioesterase","Cytoplasm, Extracellular","Several matches in gapped BLAST to acyl-ACP thioesterase and to hypotheticals: residues 1-242 are 51% similar to the hypothetical in S.pneumoniae (gi15903308). Residues 6-211 are 29% similar to acyl-ACP thioesterase from Clostridium acetobutylicum (gi15896825).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0891 (1e-79).","

InterPro
IPR002864
Family

Acyl-ACP thioesterase
PF01643	$\"[2-241]T$	Acyl-ACP_TE

noIPR
unintegrated

unintegrated
G3DSA:3.10.129.10	$\"[5-136]T$	G3DSA:3.10.129.10
SSF54637	$\"[4-134]T$ $\"[152-239]T$	SSF54637

","No hits to the COGs database.","***** IPB002864 (Acyl-ACP thioesterase) with a combined E-value of 1.4e-11. IPB002864C 39-81 IPB002864D 83-132 IPB002864E 147-185 IPB002864F 186-215","Residues 2-239 are 23% similar to a (THIOESTERASE HYDROLASE ACYL-ACP CARRIER) protein domain (PD003078) which is seen in Q9FQX7_EEEEE.Residues 1-121 are 52% similar to a (PROTEOME COMPLETE YLFF) protein domain (PD399085) which is seen in Q9CGF4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jul 28 12:47:14 2006","Fri Jul 28 12:46:52 2006","Fri Jul 28 12:46:03 2006","Thu Mar 7 15:54:40 2002","Thu Mar 7 15:54:40 2002","Thu Mar 7 15:54:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1292 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 7 15:54:40 2002","","No significant hits to the NCBI PDB database.","SMU.1417c","","No significant hits to the Pfam 11.0 database","Thu Mar 7 15:54:40 2002","24379820","","","Dormann,P., Kridl,J.C. and Ohlrogge,J.B.Cloning and expression in Escherichia coli of a cDNA coding for the oleoyl-acyl carrier protein thioesterase from coriander (Coriandrum sativum L.)Biochim. Biophys. Acta 1212 (1), 134-136 (1994)PubMed: 8155723","","Fri Mar 8 13:32:39 2002","1","","","SMU.1417c","670" "SMu1293","1348198","1347056","1143","ATGTCTAAAAAACCTACGTCAGCCTATGTGCATATTCCTTTTTGTACACAGATTTGCTATTATTGCGATTTTTCAAAAGTTTTTATTAAAAATCAGCCTGTAGATGCTTATTTGGAGGCCCTGATTAAGGAGTTTAATGATTACTATCAGATTAAGGACTTGCAAACCCTCTATATTGGCGGCGGTACACCAACAGCCATTTCTGGGGAGCAATTGGATTACCTGCTGACTAATCTGTCGAAAAATCTCAATCTTAATATGTTGGAAGAATTTACCATTGAAGCAAATCCGGGAGATTTGACACCGGATAAAGTAGCAGTGTTGAAGCAATCAGCTGTTAATCGTGTTTCTTTAGGTGTACAGACTTTTAATAATAAGCATCTGAAACAAATTGGACGCGGACATAATGAAGCTCAGATTTATGAAAGTATTGACAGTTTAAAAAGTGCTGGTTTTGATAATATTTCTATTGACTTGATTTATGCCCTGCCCAATCAAACCATAACTGATGTCAAAGAAAATGTAGCTAAAGCGCTGGCCTTGGATATTCCGCATCTGAGCCTTTACAATTTGATTTTGGAACATCATACGGTTTTTATGAATAAAATGCGACGCGGGAAACTCAATCTGCCAGCAGAAGATTTGGAGGCGGAAATGTTTGACTATATCATTTCTGAAATGGAAGATCATGGTTTTGAGCATTATGAAATTTCTAACTTTACCAAGCCTGGTTTTGAAAGCCGTCACAATCTGATGTATTGGAACAATGCTGAGTATTTTGGCTGCGGTGCAGGGGCTTCGGGCTATGTTGATGGTATCCGCTATCGTAACCGCGGGCCTATCCAGCATTATTTGAAAGCTATTAAGGAAAAGAGACAGGCTCGCTTTCAAGAAGAAAGGTTAAGTCAATCGGAGAAAATGGAAGAAGAACTCTTTTTGGGTTTGCGAAAGAAATCGGGGATTTCAATTCAGCGATTTGAAGACAAATTTGGTTTGCCTTTAATGGAAGTTTATGGTCAGGCTATTGATGACTTAGAGAAGGATGGTCTGATTTTAGTGGAAAAAGATTGTATTAGGATGAGTAAAAAAGGTCTCTTTTTGGGAGATACTGTTGCTGAGAAATTTATTTTGGAGCAGAAATAA","5.70","-7.79","43480","MSKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDAYLEALIKEFNDYYQIKDLQTLYIGGGTPTAISGEQLDYLLTNLSKNLNLNMLEEFTIEANPGDLTPDKVAVLKQSAVNRVSLGVQTFNNKHLKQIGRGHNEAQIYESIDSLKSAGFDNISIDLIYALPNQTITDVKENVAKALALDIPHLSLYNLILEHHTVFMNKMRRGKLNLPAEDLEAEMFDYIISEMEDHGFEHYEISNFTKPGFESRHNLMYWNNAEYFGCGAGASGYVDGIRYRNRGPIQHYLKAIKEKRQARFQEERLSQSEKMEEELFLGLRKKSGISIQRFEDKFGLPLMEVYGQAIDDLEKDGLILVEKDCIRMSKKGLFLGDTVAEKFILEQK","1347071","For other 'hem' genes see SMu0992 (hemK) and SMu1872 (hemZ). ","coproporphyrinogen III oxidase","Cytoplasm","Several matches in gapped BLAST to coproporphyrinogen III oxidase: residues 1-378 are 74% similar to the enzyme in S.pyogenes (gi|15675037|) and are 69% similar to the protein from S.pneumoniae (gi|15901263|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0890 (1e-163).","

InterPro
IPR004559
Family

Putative oxygen-independent coproporphyrinogen III oxidase
TIGR00539	$\"[6-367]T$	hemN_rel

InterPro
IPR006638
Domain

Elongator protein 3/MiaB/NifB
SM00729	$\"[5-222]T$	Elp3

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[9-178]T$	Radical_SAM

InterPro
IPR010723
Domain

HemN, C-terminal
PF06969	$\"[251-366]T$	HemN_C

noIPR
unintegrated

unintegrated
PTHR13932	$\"[1-377]T$	PTHR13932
SSF102114	$\"[4-376]T$	SSF102114

","BeTs to 11 clades of COG0635COG name: Coproporphyrinogen III oxidase and related FeS oxidoreductasesFunctional Class: HThe phylogenetic pattern of COG0635 is -----QvCEBrhUJ--olINxNumber of proteins in this genome belonging to this COG is 1","***** IPB003401 (Oxygen-independent coproporphyrinogen III oxidase) with a combined E-value of 1.6e-34. IPB003401B 7-22 IPB003401C 54-67 IPB003401D 90-135 IPB003401E 151-195","Residues 5-44 are 65% similar to a (PROTEOME COMPLETE III OXIDASE) protein domain (PD332371) which is seen in Q9KD75_BACHD.Residues 191-234 are 54% similar to a (III PROTEOME COMPLETE COPROPORPHYROGEN) protein domain (PD376450) which is seen in Q9CGF7_LACLA.Residues 7-73 are 42% similar to a (III PROTEOME BH1152 COMPLETE) protein domain (PD414826) which is seen in Q9KDQ9_BACHD.Residues 2-73 are 33% similar to a (III PROTEOME COMPLETE OXYGEN-INDEPENDENT) protein domain (PD393461) which is seen in Q9PQL7_UREPA.Residues 7-44 are 68% similar to a (OXIDASE III COPROPORPHYRINOGEN) protein domain (PD354278) which is seen in Q9CGF7_LACLA.Residues 56-292 are 35% similar to a (PROTEOME COMPLETE OXIDASE III COPROPORPHYRINOGEN) protein domain (PD000690) which is seen in O67418_AQUAE.Residues 118-190 are 43% similar to a (COMPLETE OXIDASE PROTEOME III) protein domain (PD342340) which is seen in O84055_CHLTR.Residues 235-329 are 60% similar to a (OXIDASE III PROTEOME COMPLETE) protein domain (PD009540) which is seen in Q9CGF7_LACLA.Residues 54-263 are 24% similar to a (III PROTEOME COMPLETE OXYGEN-INDEPENDENT) protein domain (PD137278) which is seen in O51600_BORBU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 08:26:19 2002","Fri Mar 8 13:40:42 2002","Fri Oct 18 08:26:19 2002","Fri Mar 8 13:40:42 2002","Fri Mar 8 13:40:42 2002","Fri Mar 8 13:40:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1293 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 8 13:54:55 2002","","No significant hits to the NCBI PDB database.","SMU.1418c","","Residues 9 to 178 (E-value = 4.3e-29) place SMu1293 in the Radical_SAM family which is described as Radical SAM superfamily (PF04055)Residues 251 to 366 (E-value = 1.4e-45) place SMu1293 in the HemN_C family which is described as HemN C-terminal region (PF06969)","Fri Mar 8 13:40:42 2002","","","","Homuth,G., Heinemann,M., Zuber,U. and Schumann,W.The genes of lepA and hemN form a bicistronic operon in BacillussubtilisMicrobiology 142 (Pt 7), 1641-1649 (1996)PubMed: 8757728","","Fri Mar 8 13:56:08 2002","1","","","SMU.1418c","340" "SMu1294","1348733","1349329","597","ATGAAGCGCAATACAGCTCAACTGAAAGAAAAGCTCATTCAAACAGGAGTTGAAGAAATCAAAAAAAATGGCCTTGATCAGCTCTCTCTTAGAACTATTGCTAAAAACTGCGGCGTCACTCATGGGACTCCTTACCGCCACTTTAAGAGTAAGGAAGATTATCTGAGAGTTGTCTTGACACGACTTTCGACTTTTCTCAATCAGGAAATAGCTCAAGGGATTGATCAAAAAGTTTCTGCTCGAGATCAGCTCGCTCAAATGGGATTTAATCTCATTACTTTTACTAAACGTTATCCTTATTTCTTTGAAGCCCTCTTTATTAAATTTCCCTTTAAGTATATGAAAATTACTCAGGAGACTATTGTACTGGATTCTGACTTACCGGGGTTTGATAAATTTAAACGTATTGTTTTCGATCTCCGTAAAGAGGAGAGCTTCACTAATAGTGAAGCTGAGACACTTTTTCACTTCTGGAGTTTTATCTCAGGTCTTGCTGTTCTAGCCAACAGTCCCATTGGGCGCGACCTTGATAATCAAGCTATCCACACGACTATTAATCATATGCTTGATATTTACATTAAAGGAGAACAAACATGA","9.80","5.15","22951","MKRNTAQLKEKLIQTGVEEIKKNGLDQLSLRTIAKNCGVTHGTPYRHFKSKEDYLRVVLTRLSTFLNQEIAQGIDQKVSARDQLAQMGFNLITFTKRYPYFFEALFIKFPFKYMKITQETIVLDSDLPGFDKFKRIVFDLRKEESFTNSEAETLFHFWSFISGLAVLANSPIGRDLDNQAIHTTINHMLDIYIKGEQT","1349338","","transcriptional regulator","Cytoplasm","Several matches in gapped BLAST to transcription regulators: residues 2-170 are 26% similar to gi|15896028| from Clostridium acetobutylicum and residues 1-105 are 25% similar to gi|15607114| from Aquifex aeolicus. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1310 (3e-04).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PR00455	$\"[12-25]T$ $\"[33-56]T$	HTHTETR
PF00440	$\"[12-58]T$	TetR_N
PS50977	$\"[6-66]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[1-84]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[9-69]T$	Homeodomain-rel

InterPro
IPR003680
Family

Flavodoxin-like fold
PF02525	$\"[1-131]T$	Flavodoxin_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[2-183]T$	G3DSA:3.40.50.360
SSF52218	$\"[1-188]T$	SSF52218

","BeTs to 3 clades of COG2249COG name: Putative NADPH-quinone reductase, YabF family (modulator of drug activity B)Functional Class: RThe phylogenetic pattern of COG2249 is --------EB-Huj-------Number of proteins in this genome belonging to this COG is 1","***** IPB003680 (NAD(P)H dehydrogenase (quinone)) with a combined E-value of 7.8e-17. IPB003680 75-106","Residues 4-125 are 42% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE NADPH PHOSPHODIESTERASE) protein domain (PD009603) which is seen in Q9K9A1_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 08:10:27 2002","Fri Mar 8 15:50:52 2002","Fri Oct 18 08:10:27 2002","Fri Mar 8 15:50:52 2002","Fri Mar 8 15:50:52 2002","Fri Mar 8 15:50:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1295 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Oct 18 08:10:27 2002","Fri Mar 8 15:50:52 2002","pdb|1QR2|A Chain A, Human Quinone Reductase Type 2 >gi|5822325|... 78 6e-016pdb|1QBG|A Chain A, Crystal Structure Of Human Dt-Diaphorase (N... 70 2e-013pdb|1D4A|A Chain A, Crystal Structure Of Human Nad[p]h-Quinone ... 70 2e-013","SMU.1420","","Residues 1 to 186 (E-value = 5.4e-46) place SMu1295 in the Flavodoxin_2 family which is described as Flavodoxin-like fold (PF02525)","Fri Mar 8 15:50:52 2002","24379823","","","","","","1","","","SMU.1420","" "SMu1296","1351205","1349952","1254","ATGGCTACAGAAATCGTGATGCCTAAATTAGGTTTAACCATGACAGAAGGGCTAATTAACCAATGGCTCGTTAAAGAAGGCGACACAGTTGCAGCTGGCGATCCCGTGTTGGAAATTAGTTCTGAAAAGTTAACAAGTGAAGTTGAAGCTCCAGAAGCTGGTGTTATTTTAAAAATAGTTAAGGGAGAAGGTGAGACTGTTCCTTGTAAACAAATCATTGCTTGGATTGGTCAAGAAGGTGAGGCTGTTCCTGACGCTGCAGGTGACGCTCCAGAAGTAGATACAGAAGCTGAAAGTGAAGTTGCTTCAGCAGGGCAAACAGTAGTTCCAGAAGAAAGCAGGACTGTTTCAGCAGCGCCCGTTGCTGAAAAGCATGAAGACGGACGGATTTTTATCACACCGCTGGCTCGAAAGATTGCCAAGGAAAAAGGGCTAGACATTACTTATATCAAAGGAACAGGCGGTAACGGACGTATCACACGCCGTGACGTTGAAGCCTTTAATCCTGCTAGCATTCCTACAGCTGAACCTGTAACAGCTTTAAGTGCTCCAACAAATGTAAACTATGGTGTTGGTTTAACAGGTATACGCAAAGTCATTGCTGAGCGCATGATGAGTAGTATCCATTCTAGTGCTCAATTAACGCTTCATCGAAAGGCAGATGTTACGCCTTTAATGGCTTTCAGGCAAGATATAAAAACTAAGGTTAATGCACCGCTTGAAAACGGGGAAATTGGCATTACAACCTTATTGACCAAAGCGGTAACGAAGGCTTTGAAAGATTATCCTGAAGCGAATGCTTGGTATGCAGGCGGTCAATATGAAGAAAAAGAAGATATTCATATTGGTATGGCAACTGCTTTGAGTGATGGTTTGGTCGTTCCTGTTATTCGTCATGCTGATAAATTAACGCTGTCAGATTTGGGACGAACTATTAAAGAAGAAGCAGAACAAGTACGTAAAGGAACTCTGGATCCATCCTTGTATTCAGGTTCCACATTCTCTATTACCAATCTAGGTGCTCAAGGCATTGAATACTTTACACCGATTTTGAATGCACCTGAAGTTGCTATCTTAGGTGTTGGGGCTATCCAGAAAGCTTTGACTCTTGATGAGAATGGTCAAGTAGCTGAAAAACAATTTTTACCACTTAGTTTGACCTTTGACCATCAAGTCTTAGATGGTGCACCAGCAGCTGAATTTTTAGGAGCTGTTATCTCCTACTTGGAAGATGCTTATAGTCTGGTATTCTAA","4.60","-20.55","44388","MATEIVMPKLGLTMTEGLINQWLVKEGDTVAAGDPVLEISSEKLTSEVEAPEAGVILKIVKGEGETVPCKQIIAWIGQEGEAVPDAAGDAPEVDTEAESEVASAGQTVVPEESRTVSAAPVAEKHEDGRIFITPLARKIAKEKGLDITYIKGTGGNGRITRRDVEAFNPASIPTAEPVTALSAPTNVNYGVGLTGIRKVIAERMMSSIHSSAQLTLHRKADVTPLMAFRQDIKTKVNAPLENGEIGITTLLTKAVTKALKDYPEANAWYAGGQYEEKEDIHIGMATALSDGLVVPVIRHADKLTLSDLGRTIKEEAEQVRKGTLDPSLYSGSTFSITNLGAQGIEYFTPILNAPEVAILGVGAIQKALTLDENGQVAEKQFLPLSLTFDHQVLDGAPAAEFLGAVISYLEDAYSLVF","1349967","SMu1296 is a component of the multienzyme pyruvate dehydrogenase complex. For other 'aco' genes see SMu1297 (acoB);SMu0113 (acoA); SMu1298 (acoA) and SMu1299 (acoL).","dihydrolipoamide acetyltransferase (acetoin dehydrogenase E2 component)","Cytoplasm","Several matches in gapped BLAST to dihydrolipoamide acetyltransferase sequences. Residues 1-416 are 41% similar to the enzyme from B.subtilis (gi|16077875|) and residues 1-410 are 39% similar to the enzyme from B.halodurans (gi|15613341).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0880 (1e-59).","

InterPro
IPR000089
Domain

Biotin/lipoyl attachment
PF00364	$\"[3-76]T$	Biotin_lipoyl
PS50968	$\"[3-76]T$	BIOTINYL_LIPOYL

InterPro
IPR001078
Domain

Catalytic domain of components of various dehydrogenase complexes
PD001115	$\"[336-405]T$	2Oxoacid_dh
PF00198	$\"[185-417]T$	2-oxoacid_dh

InterPro
IPR004167
Domain

E3 binding
PF02817	$\"[132-168]T$	E3_binding

InterPro
IPR011053
Domain

Single hybrid motif
SSF51230	$\"[1-98]T$	Hybrid_motif

noIPR
unintegrated

unintegrated
G3DSA:2.40.50.100	$\"[4-98]T$	G3DSA:2.40.50.100
G3DSA:3.30.559.10	$\"[191-417]T$	G3DSA:3.30.559.10
G3DSA:4.10.320.10	$\"[121-171]T$	G3DSA:4.10.320.10
PTHR23151	$\"[4-390]T$	PTHR23151
PTHR23151:SF19	$\"[4-390]T$	PTHR23151:SF19
SSF47005	$\"[121-171]T$	SSF47005
SSF52777	$\"[185-417]T$	SSF52777

","BeTs to 8 clades of COG0508COG name: Dihydrolipoamide acyltransferasesFunctional Class: CThe phylogenetic pattern of COG0508 is ----Y--cEBRH--gp--INXNumber of proteins in this genome belonging to this COG is 2","***** IPB001078 (2-Oxo acid dehydrogenase acyltransferase catalytic domain) with a combined E-value of 2.5e-71. IPB001078A 22-54 IPB001078B 134-164 IPB001078C 244-265 IPB001078D 319-361 IPB001078E 381-417***** IPB003016 (2-oxo acid dehydrogenases acyltransferase component lipoyl binding site) with a combined E-value of 2.5e-13. IPB003016 25-59***** IPB000089 (Biotin / Lipoyl attachment) with a combined E-value of 4.1e-11. IPB000089A 281-300 IPB000089B 335-354***** IPB001882 (Biotin-requiring enzymes attachment site) with a combined E-value of 1.9e-08. IPB001882H 14-59","Residues 7-73 are 46% similar to a (BIOTIN DIHYDROLIPOAMIDE LIPOYL CARBOXYLASE TRANSFERASE) protein domain (PD000268) which is seen in Q9KES1_BACHD.Residues 92-176 are 41% similar to a (ACYLTRANSFERASE DIHYDROLIPOAMIDE) protein domain (PD294180) which is seen in Q9RPS3_ENTFA.Residues 129-165 are 56% similar to a (DIHYDROLIPOAMIDE TRANSFERASE) protein domain (PD333986) which is seen in ODP2_SCHPO.Residues 91-167 are 38% similar to a (TRANSFERASE DIHYDROLIPOAMIDE LIPOYL) protein domain (PD293828) which is seen in ODP2_YEAST.Residues 197-416 are 43% similar to a (DIHYDROLIPOAMIDE TRANSFERASE LIPOYL DEHYDROGENASE E2) protein domain (PD001115) which is seen in ACOC_BACSU.Residues 131-164 are 58% similar to a (DIHYDROLIPOAMIDE TRANSFERASE LIPOYL E2 ACYLTRANSFERASE) protein domain (PD001730) which is seen in ODP2_HUMAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 07:54:50 2002","Thu May 2 11:33:07 2002","Fri Oct 18 07:54:50 2002","Fri Mar 8 16:00:31 2002","Fri Mar 8 16:00:31 2002","Fri Mar 8 16:00:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1296 is paralogously related (blast p-value < 1e-3) to SMu0115, a predicted dihydrolipoamide S-acetyltransferase and SMu0116, a predicted dihydrolipoamide dehydrogenase.","Fri Mar 8 16:00:31 2002","Fri Mar 8 16:00:31 2002","pdb|1B5S|A Chain A, Dihydrolipoyl Transacetylase (E.C.2.3.1.12)... 131 1e-031pdb|1E2O| Catalytic Domain From Dihydrolipoamide Succinyltra... 112 7e-026pdb|1DPC| Dihydrolipoyl Transacetylase (E.C.2.3.1.12) (Catal... 106 4e-024","SMU.1421c","","Residues 3 to 76 (E-value = 1.7e-20) place SMu1296 in the Biotin_lipoyl family which is described as Biotin-requiring enzyme (PF00364)Residues 132 to 168 (E-value = 1.8e-15) place SMu1296 in the E3_binding family which is described as e3 binding domain (PF02817)Residues 185 to 417 (E-value = 1.9e-81) place SMu1296 in the 2-oxoacid_dh family which is described as 2-oxoacid dehydrogenases acyltransferase (catalytic domain) (PF00198)","Fri Mar 8 16:00:31 2002","","","","Yamamoto,H., Uchiyama,S. and Sekiguchi,J.Cloning and sequencing of a 40.6 kb segment in the 73 degrees-76degrees region of the Bacillus subtilis chromosome containing genes for trehalose metabolism and acetoin utilizationMicrobiology 142 (Pt 11), 3057-3065 (1996)PubMed: 8969503","","Fri Mar 8 16:01:13 2002","1","","","SMU.1421c","" "SMu1297","1352250","1351219","1032","ATGGCTAGAGAACTATTATTTATGAAAGCAATTAATGAAGCGCTTGATATGGCAATGGCCAAAGATGACAAAATTATTTTACTTGGTGAAGATATTGCAGGTGGTGTTAAGGTTAAACATTTAGAAGAGCAAAACGAAGAAGCCTGGGGCGGTGTTATGGGGGTTACCAGCGGTTTAATGGCTAAATACAGTCGTGATCGTGTTATTGACACCCCTCTTTCAGAACATGGTTACATGTCAGCTTCTGTTGGGATGGCTTTGACGGGATTGCATCCTGTGCCAGAATTGATGTTCAATGACTTTATTGGTTTTTGTTTTGATGCTTTGATTGGCCAAGGGTCGAAAATGCGTTATATGTTTGGTGGCAAGGCAAAAGTGCCGATGACCGTTCGTACCATGCATGGTGCAGGCGCTTCAGCTGCTGCACAGCACTCAGGATCTTACTATGGCATCTTTGGTTCAATCCCAGGAATTAAGGTAGTTGTTCCAGCGACACCTTATGATGCCAAGGGTCTGCTTCTTTCTGCTCTTGAAGATGATAATATTGTTATCTTTTCAGAAGATAAGACGTTGTATGGCTTTAAAGGTGAAGTGCCAGAGGATTATTATACCGTTCCGATTGGAAAGGCAGTTGTCCGTCGTGAAGGTAATGATTTAACCATTGTAACTATTGGTAAAATGCTCTATGTGGCTTATGAAGTAGCAGATCGTTTGGCTAAGGATGGCATTTCTGTTGAAGTCATTGATCTTAGAACAGTTGCACCTTGGGATCAAGAAACCGTTCTAAATTCTGTGAAAAAGACAGGACGCTTGATTGTGATTGATGAATCAAACCCACATAATAATACAGCGACAGATATTGCTTCTGTTGTTAATGATAAGGCATTCGATTATCTAGATGGTCCAATTAAATGTGTTTGTGCACCAAATGTACCTGTTCCGTTTGCCATCAATCTTGAACAACTATACATCCCTAATGCAGACCGTGTCATTGAAGCAGCAGCTGAATTGATTGACGACTTGAAAGCATAG","4.70","-13.67","37158","MARELLFMKAINEALDMAMAKDDKIILLGEDIAGGVKVKHLEEQNEEAWGGVMGVTSGLMAKYSRDRVIDTPLSEHGYMSASVGMALTGLHPVPELMFNDFIGFCFDALIGQGSKMRYMFGGKAKVPMTVRTMHGAGASAAAQHSGSYYGIFGSIPGIKVVVPATPYDAKGLLLSALEDDNIVIFSEDKTLYGFKGEVPEDYYTVPIGKAVVRREGNDLTIVTIGKMLYVAYEVADRLAKDGISVEVIDLRTVAPWDQETVLNSVKKTGRLIVIDESNPHNNTATDIASVVNDKAFDYLDGPIKCVCAPNVPVPFAINLEQLYIPNADRVIEAAAELIDDLKA","1351234","For the alpha subunit, see SMu0113 and SMu1298.For the beta subunit, see SMu0114.For other 'aco' genes see SMu0113 (acoA);SMu1296 (acoC); SMu1298 (acoA) and SMu1299 (acoL).From Genbank:[gi:7531027]This enzyme catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde ","acetoin dehydrogenase E1 component","Cytoplasm","Several matches in gapped BLAST to acetoin dehydrogenase E1 component.Residues 1-338 are 56% similar to the enzyme from B.halodurans (gi|15675027) and residues 1-340 are 53% similar to the enzyme from B.subtilis (gi|16077874|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0879 (6e-64).","

InterPro
IPR005475
Domain

Transketolase, central region
PF02779	$\"[3-195]T$	Transket_pyr

InterPro
IPR005476
Domain

Transketolase, C-terminal
PF02780	$\"[208-330]T$	Transketolase_C

InterPro
IPR009014
Domain

Transketolase, C-terminal-like
G3DSA:3.40.50.920	$\"[212-340]T$	Transketo_C_like
SSF52922	$\"[202-339]T$	Transketo_C_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.970	$\"[1-210]T$	G3DSA:3.40.50.970
PTHR11624	$\"[52-343]T$	PTHR11624
PTHR11624:SF21	$\"[52-343]T$	PTHR11624:SF21
SSF52518	$\"[1-218]T$	SSF52518

","BeTs to 7 clades of COG0022COG name: Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunitFunctional Class: CThe phylogenetic pattern of COG0022 is ----y--c-Br---gp--INxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 66-261 are 57% similar to a (SYNTHASE THIAMINE DEHYDROGENASE PYROPHOSPHATE PYRUVATE) protein domain (PD000580) which is seen in Q9KBV1_BACHD.Residues 10-55 are 63% similar to a (DEHYDROGENASE BETA PYRUVATE SUBUNIT) protein domain (PD000629) which is seen in Q9KBV1_BACHD.Residues 296-337 are 50% similar to a (PYRUVATE BETA DEHYDROGENASE SUBUNIT) protein domain (PD163062) which is seen in ODPB_RICPR.Residues 284-338 are 54% similar to a (BETA DEHYDROGENASE SUBUNIT PYRUVATE) protein domain (PD151765) which is seen in Q9KBV1_BACHD.Residues 2-56 are 49% similar to a (OXIDOREDUCTASE TPP-DEPENDENT BETA-SUBUNIT) protein domain (PD166378) which is seen in ACOB_ALCEU.Residues 228-278 are 39% similar to a (BETA ALPHA-KETO SUBUNIT BRANCHED-CHAIN) protein domain (PD166298) which is seen in Q9RPS4_ENTFA.Residues 151-192 are 59% similar to a (SUBUNIT BETA OXIDOREDUCTASE DEHYDROGENASE) protein domain (PD344304) which is seen in Q48430_KLEPN.Residues 56-133 are 52% similar to a (BETA DEHYDROGENASE SUBUNIT E1) protein domain (PD247144) which is seen in Q48430_KLEPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 07:54:22 2002","Fri Mar 8 16:11:20 2002","Fri Oct 18 07:54:22 2002","Fri Mar 8 16:11:20 2002","","Mon Dec 17 14:13:49 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1297 is paralogously related (blast p-value < 1e-3) to SMu0114, a predicted acetoin dehydrogenase (TPP-dependent) E1 component beta subunit.","Fri Mar 8 16:12:31 2002","Mon Dec 17 14:13:49 2001","pdb|1DTW|B Chain B, Human Branched-Chain Alpha-Keto Acid Dehydr... 213 2e-056pdb|1QS0|B Chain B, Crystal Structure Of Pseudomonas Putida 2-O... 203 3e-053pdb|1DTW|B Chain B, Human Branched-Chain Alpha-Keto Acid Dehydr... 468 6e-133","SMU.1422c","","Residues 5 to 195 (E-value = 2.8e-59) place SMu1297 in the Transket_pyr family which is described as Transketolase, pyridine binding domain (PF02779)Residues 208 to 330 (E-value = 5.3e-50) place SMu1297 in the Transketolase_C family which is described as Transketolase, C-terminal domain (PF02780)","Mon Dec 17 14:13:49 2001","","","","Huang,M., Oppermann-Sanio,F.B. and Steinbuchel,A.Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathwayJ. Bacteriol. 181 (12), 3837-3841 (1999)PubMed: 10368162Ali NO, Bignon J, Rapoport G, Debarbouille M. Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis. J Bacteriol. 2001 Apr;183(8):2497-504. PMID: 11274109 ","","Fri Mar 8 16:12:31 2002","1","","","SMU.1422c","" "SMu1298","1353336","1352263","1074","ATGCCAAACTATAAAGATTTACCACAAGAACTAACAAGAACAAGGACAAATGAAGCTGTTTCGGAACTTGTTGATTTGAAGGTTCACACGGCAACAGATATTGAAGCCCAAGAAGTTTCCAAAGAGCAAGCTAAAGATATGTATAAAACCATGTGGGATATTCGTAATTTTGAGGAAAATGCTAGACGTTTCTTTGCAGCGGGGCAAATTCCTGGTTTTGTTCATTTGTATGCAGGTGAAGAAGCCGTAGCCGCAGGAGTCTGTGCCAATTTAACGGATAAAGACTATATTACCAGTACCCACCGTGGGCATGGTCATTGTGTGGCCAAGGGTGGTGACCTTAAGGGCATGATGGCTGAAATTTTTGGCAAGGAGACAGGTCTTGGCAAGGGTAAAGGTGGCTCCATGCACATTGCTGATTTGGACAAGGGAATCCTTGGTGCCAATGGTATGGTTGGTGGCGGTTTTGGTCTGGCAACTGGAGCTGCTATGCGTAATAAGTATCTTAAGACTGATGATGTTGCTGTTTGTTTCTTTGGAGATGGTGCCGCTAATGAAGGCCTTTTCCATGAATGTTTAAATATGGCTTCTATTTGGAAATTGCCTGTTATTTTTGTCAATGAAAATAACCTGTTTGCTGAATCAACACCACAATGGTATTCATCAGCATCAGCTACCATTGCCGAAAGGGCATTGGCTTATGATATGCCTGGTGTTCGTGTTAATGGGAAAGATCTCTTTGCCGTCTATCAAGTGGCTAAAGAAGCTGTTGAACGTGCTAGATCTGGTCAAGGGCCAACTTTGATTGAAGCTGTTACTTACCGTGATCATGGTCACTTTGAAGGGGATGAACAAAAATATAAAGCTCCAGACGGAGAAGAAAAAGACTGGGCAGATGTTGATCCACTAGAAGTTTTCCGCAATTATACTATTGAACATGAGCTATTGACAGAAGAAGAATTGGATGAAATATTAGAAGAATCAAAGAAAGATGTTGATGATGCCATTAAATATGCTCAAGACAGTCCAATTCCTAAAGCAGAATCACTACTTGAAGATGTATTTGCTGAGTAA","4.60","-23.73","39291","MPNYKDLPQELTRTRTNEAVSELVDLKVHTATDIEAQEVSKEQAKDMYKTMWDIRNFEENARRFFAAGQIPGFVHLYAGEEAVAAGVCANLTDKDYITSTHRGHGHCVAKGGDLKGMMAEIFGKETGLGKGKGGSMHIADLDKGILGANGMVGGGFGLATGAAMRNKYLKTDDVAVCFFGDGAANEGLFHECLNMASIWKLPVIFVNENNLFAESTPQWYSSASATIAERALAYDMPGVRVNGKDLFAVYQVAKEAVERARSGQGPTLIEAVTYRDHGHFEGDEQKYKAPDGEEKDWADVDPLEVFRNYTIEHELLTEEELDEILEESKKDVDDAIKYAQDSPIPKAESLLEDVFAE","1352278","For the alpha subunit, see SMu0113 and SMu1298. For the beta subunit, see SMu0114 and SMu1297. For other 'aco' genes see SMu1297 (acoB);SMu1296 (acoC); SMu0113 (acoA) and SMu1299 (acoL).From Genbank:[gi:113136] This enzyme catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde.In vitro the alpha subunit is probably the catalytic subunit of the enzyme.","acetoin dehydrogenase E1 component","Cytoplasm","Several matches in gapped BLAST to acetoin dehydrogenase E1 component: residues 35-355 are 51% similar to the enzyme in B.subtilis (gi|16077873|). Residues 39-355 are 50% similar to the protein from B.halodurans (gi|15614385|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0878 (3e-60).","

InterPro
IPR001017
Domain

Dehydrogenase, E1 component
PF00676	$\"[49-348]T$	E1_dh

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.970	$\"[38-357]T$	G3DSA:3.40.50.970
PTHR11516	$\"[35-357]T$	PTHR11516
PTHR11516:SF6	$\"[35-357]T$	PTHR11516:SF6
SSF52518	$\"[29-357]T$	SSF52518

","BeTs to 7 clades of COG1071COG name: Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunitFunctional Class: CThe phylogenetic pattern of COG1071 is ----y--c-BR---gp--INxNumber of proteins in this genome belonging to this COG is 2","***** IPB001017 (Dehydrogenase, E1 component) with a combined E-value of 1e-79. IPB001017A 46-58 IPB001017B 72-104 IPB001017C 120-139 IPB001017D 178-216 IPB001017E 236-249 IPB001017F 264-284","Residues 150-282 are 63% similar to a (SYNTHASE THIAMINE DEHYDROGENASE PYROPHOSPHATE PYRUVATE) protein domain (PD000580) which is seen in O31404_BACSU.Residues 39-139 are 57% similar to a (PYRUVATE DEHYDROGENASE ALPHA SUBUNIT E1 OXIDOREDUCTASE) protein domain (PD001490) which is seen in Q46142_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 07:53:54 2002","Mon Mar 11 09:07:33 2002","Fri Oct 18 07:53:54 2002","Mon Mar 11 08:38:26 2002","Mon Mar 11 08:38:26 2002","Mon Mar 11 08:38:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1298 is paralogously related (blast p-value < 1e-3) to SMu0113, also a acetoin dehydrogenase (TPP-dependent) E1 component alpha subunit.","Mon Mar 11 09:07:33 2002","Mon Mar 11 08:38:26 2002","pdb|1DTW|A Chain A, Human Branched-Chain Alpha-Keto Acid Dehydr... 117 2e-027pdb|1QS0|A Chain A, Crystal Structure Of Pseudomonas Putida 2-O... 93 4e-020","SMU.1423c","","Residues 49 to 348 (E-value = 2.6e-124) place SMu1298 in the E1_dh family which is described as Dehydrogenase E1 component (PF00676)","Mon Mar 11 08:38:26 2002","","","","Ali NO, Bignon J, Rapoport G, Debarbouille M. Regulation of the acetoin catabolic pathway is controlled by sigma L inBacillus subtilis. J Bacteriol. 2001 Apr;183(8):2497-504. PMID: 11274109 Huang M, Oppermann-Sanio FB, Steinbuchel A. Biochemical and molecular characterization of the Bacillus subtilis acetoincatabolic pathway. J Bacteriol. 1999 Jun;181(12):3837-41. PMID: 10","","Mon Apr 1 08:27:11 2002","1","","","SMU.1423c","" "SMu1299","1354699","1353362","1338","TTGGCTAAGTATGATCTTTTAATTATTGGTGCTGGACCCGGTGGTTATATTGCAGCTGAAGAGGCTGCAAGATTAGGCAAAAAAGTTGCTGTCGTTGAAAAAAAAGACATTGGCGGAACTTGTTTAAACGTTGGCTGTATTCCTTCCAAGGCTTATCTGCAGCACAGTCATTGGTTATTATCAATGCAGGAAGCTAACAAATACGGCATTTCAACTAATCTTGAAAGTGTAGACTTTGCTAAGTTAGTCAATCGTAAAGATCAGGTTGTTTCGACTTTACAAGGAGGTATTCACACAACTTTTAAATCTCTAAAAATTGATTATTATGAAGGCCAAGCACAATTTCTTAAAGACAAGAGCTTTATGGTCAATGGTGAAAAGATTTCTGGGAAAGATGTTATTTTAGCGACTGGTAGCCATCCTTTTATTCCGCAAATTCATGGTATTAATTCGGTGAATTACCTAACAACAGATAGCTTTTTCAATTTAAAAGTTTTACCAGAGAAATTGGTTATCATTGGTGGGGGTGTTATTGCGATTGAATTAGCCTTTGCCATGCAGCCATTGGGTGTGAATGTCACTGTCATTGAAATTGCACCGCAAATACTATTGACAGAGGATAAAGCTGCACGTGCTATTATCAGAAAGAAACTCAAAACAATGGGAGCTCATATTTTTGAAGCTGCTAAGATAGAAGAAGTACATGCTCAATCAGTTATTTTAGAGGGGGATGGCGCTCAAGAATTTGACCAGTTGTTAGTTGCAACAGGACGTAAGCCTAATACAGAATTAGCTCAGGAAATGGGATTAAAGCTAACAGAACGTGGTTTTGTCAAAGTTGATGATTACTATGAAACGTCTACTCCACATGTTTATGCTATCGGTGACTTGACGGAAAGTTATATGCTAGCTCATGTTGCCAGCATGGAAGGCATCAAAGCTGTTAGAGCTATTTGTCGTCAGGCACAGGATCCTGTTGATGCTCAAGGTGTACCGCGTTCGCTCTACACCAATCCGGAAGTGGCTTCCTTTGGACTGAGTGAAGAGGAGGCTAAAGAACAAGGTTATGATGTCCTCGTTGAACAATTACCATTTTCTTTCAACGGACGGGCCATTGCATCAACAGAGACGCAAGGATTTGTTAAACTGATTTCGGAAAGGAGGTATCATCAAATTTTAGGGGCTGTTATTGTTGGCGAACATGGGACAGATTTGTTGCAACAATTGATTTTATTGAGACAGGCAGAAGGAACTTTTGATCAAGTTGTTGATGCAGTCTATGCCCATCCGACAATTTCAGAACTCATTCAAGAAGTTGCTAAGCGAATTGTTCAGTAA","5.80","-8.22","48655","MAKYDLLIIGAGPGGYIAAEEAARLGKKVAVVEKKDIGGTCLNVGCIPSKAYLQHSHWLLSMQEANKYGISTNLESVDFAKLVNRKDQVVSTLQGGIHTTFKSLKIDYYEGQAQFLKDKSFMVNGEKISGKDVILATGSHPFIPQIHGINSVNYLTTDSFFNLKVLPEKLVIIGGGVIAIELAFAMQPLGVNVTVIEIAPQILLTEDKAARAIIRKKLKTMGAHIFEAAKIEEVHAQSVILEGDGAQEFDQLLVATGRKPNTELAQEMGLKLTERGFVKVDDYYETSTPHVYAIGDLTESYMLAHVASMEGIKAVRAICRQAQDPVDAQGVPRSLYTNPEVASFGLSEEEAKEQGYDVLVEQLPFSFNGRAIASTETQGFVKLISERRYHQILGAVIVGEHGTDLLQQLILLRQAEGTFDQVVDAVYAHPTISELIQEVAKRIVQ","1353377","For other 'aco' genes see SMu1297 (acoB);SMu1296 (acoC); SMu1298 (acoA) and SMu0113 (acoA)For other 'adh' genes see SMu0107 (adh);SMu0113 (adhA); SMu0114 (adhB); SMu0115 (adhC); SMu0116 (adhD); SMu0131 (adhE) and SMu1698 (adhB).","dihydrolipoamide dehydrogenase","Cytoplasm","Several matches in gapped BLAST to dihydrolipoamide dehydrogenase sequences. Residues 1-440 are 36% similar to the enzyme from B.halodurans (gi|15613342|). Residues 3-438 are 36% similar to gi|15675028| from S.pyogenesThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0881 (4e-72).","

InterPro
IPR000759
Family

Adrenodoxin reductase
PR00419	$\"[5-27]T$ $\"[170-184]T$	ADXRDTASE

InterPro
IPR000815
Family

Mercuric reductase
PR00945	$\"[15-33]T$ $\"[134-151]T$ $\"[169-186]T$ $\"[189-204]T$ $\"[363-383]T$	HGRDTASE

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[5-27]T$ $\"[37-52]T$ $\"[133-142]T$ $\"[169-194]T$ $\"[250-264]T$ $\"[291-298]T$ $\"[327-348]T$ $\"[392-407]T$ $\"[414-434]T$	PNDRDTASEI

InterPro
IPR001327
Domain

Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region
PD000139	$\"[137-196]T$	Q8DTC8_STRMU_Q8DTC8;
PF00070	$\"[169-257]T$	Pyr_redox

InterPro
IPR004099
Domain

Pyridine nucleotide-disulphide oxidoreductase dimerisation region
G3DSA:3.30.390.30	$\"[324-445]T$	no description
PF02852	$\"[331-440]T$	Pyr_redox_dim

InterPro
IPR006258
Family

Dihydrolipoamide dehydrogenase
TIGR01350	$\"[3-445]T$	lipoamide_DH: dihydrolipoamide dehydrogenas

InterPro
IPR012999
Active_site

Pyridine nucleotide-disulphide oxidoreductase, class I, active site
PS00076	$\"[38-48]T$	PYRIDINE_REDOX_1

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[5-27]T$ $\"[133-142]T$ $\"[169-194]T$ $\"[250-264]T$ $\"[291-298]T$	FADPNR
PF07992	$\"[5-302]T$	Pyr_redox_2

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[2-323]T$	no description
PTHR22912	$\"[7-440]T$	DISULFIDE OXIDOREDUCTASE
PTHR22912:SF20	$\"[7-440]T$	DIHYDROLIPOAMIDE DEHYDROGENASE-RELATED

","BeTs to 11 clades of COG1249COG name: Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymesFunctional Class: CThe phylogenetic pattern of COG1249 is amt-YqvCEBRH--gp--inXNumber of proteins in this genome belonging to this COG is 4","***** PR00368 (FAD-dependent pyridine nucleotide reductase signature) with a combined E-value of 9.5e-37. PR00368A 5-27 PR00368B 133-142 PR00368C 169-194 PR00368D 250-264 PR00368E 291-298 PR00368A 169-191***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 4.9e-18. IPB000103A 5-25 IPB000103C 135-183 IPB000103D 251-262 IPB000103E 286-323***** IPB001100 (Pyridine nucleotide-disulphide oxidoreductase, class I) with a combined E-value of 6.6e-08. IPB001100 38-52***** IPB000171 (Bacterial-type phytoene dehydrogenase) with a combined E-value of 2.2e-07. IPB000171A 7-37 IPB000171A 171-201","Residues 133-197 are 40% similar to a (REDUCTASE OXIDOREDUCTASE FAD) protein domain (PD040523) which is seen in O52935_MOOTH.Residues 24-440 are 38% similar to a (OXIDOREDUCTASE FLAVOPROTEIN FAD CENTER REDOX-ACTIVE) protein domain (PD000139) which is seen in Q9KES0_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 07:52:48 2002","Mon Mar 11 09:17:01 2002","Tue Oct 15 16:13:06 2002","Mon Mar 11 09:17:01 2002","Mon Mar 11 09:17:01 2002","Mon Mar 11 09:17:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1299 is paralogously related (blast p-value < 1e-3) to SMu0116,another dihydrolipoamide dehydrogenase, to SMu0762 and SMu0126, both predicted glutathione reductase,SMu1020 and SMu0693, both predicted NADH oxidases, SMu0420 and SMu0792, both predicted thioredoxin reductase (NADPH) and SMu1286, a predicted fumarate reductase.","Mon Mar 11 09:24:26 2002","Mon Mar 11 09:17:01 2002","pdb|1EBD|A Chain A, Dihydrolipoamide Dehydrogenase Complexed Wi... 261 9e-071pdb|3LAD|A Chain A, Dihydrolipoamide Dehydrogenase (E.C.1.8.1.4... 251 1e-067pdb|1LPF|A Chain A, Dihydrolipoamide Dehydrogenase (E.C.1.8.1.4... 242 7e-065","SMU.1424c","","Residues 5 to 306 (E-value = 4.9e-79) place SMu1299 in the Pyr_redox family which is described as Pyridine nucleotide-disulphide oxidoreductase (PF00070)Residues 331 to 440 (E-value = 5.1e-39) place SMu1299 in the Pyr_redox_dim family which is described as Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (PF02852)","Mon Mar 11 09:17:01 2002","","","","Tozawa K, Broadhurst RW, Raine AR, Fuller C, Alvarez A, Guillen G, Padron G, Perham RN. Solution structure of the lipoyl domain of the chimeric dihydrolipoyl dehydrogenase P64K from Neisseria meningitidis. Eur J Biochem. 2001 Sep;268(18):4908-17. PMID: 11559360Kruger,N., Oppermann,F.B., Lorenzl,H. and Steinbuchel,A.Biochemical and molecular characterization of the Clostridiummagnum acetoin dehydrogenase enzyme systemJ. Bacteriol. 176 (12), 3614-3630 (1994)PubMed: 8206840","Mon Mar 11 09:19:23 2002","Mon Mar 11 09:19:23 2002","1","","","SMU.1424c","" "SMu1300","1357510","1354928","2583","ATGATCGATAAAATGACTCAGTTAGTTGAAGATTCTTTAGAAGAAGCAAAGGAATTGGCTATTGCTCATCGTAATTATCAGCTGGACATTCCCCATTTATGGGCTGTCTTGGTAAAACCTGATCAATTTGCTTTTCAATTCTATCAATCTTTAGAAATAAATACCAATCAGCTGATTGAGATTATCAATAAAGAAATAGATAAAATCCCAGTCCTTTCAAGTACAGAAAAAAGCAGTTATGCACGTTTATACAGTCAGCGTTTAAAAAATTTATTGGATGACGCGCATCAGGAAATGATTGATTTAAAGGATCAGGTGCTGACTGTAGAACACTTGATCTTGGCACTTTTTAACCAACAACGCAATCCCATTACTGTTTTTTTGCTTGAACAGGGTCTAAACAAAGAAAAACTTTATCAAAAGATGCATAGGATTCGTAAAGGGAAACCTGCTATTTCTTCCAGTCAAGAAACTATTTATGATGCTTTAGAAAAGTATGCTGTCAACTTAAATCAGCGTGCTTTAGATGAACCTGTTAATAAAATTATTGGTCGTCAGGATGAAATGAATGATATTATTCGTATTTTATCGCGTAAGAATAAGAATAATGCCGTTTTGGTTGGTCATTCAGGTGTTGGAAAAACAGCCATTATTGAAGGATTTGTTCAGCGGTTAGTTAAAAATCAAGTTCCGAAAAATTTGCAAGGTAAGGTCATTTACAGTCTTGACATAGGAGCCTTGCTGGCAGGAACTAAATACCGCGGTGAATTTGAAGAACGTTTTAAAGCTCTTCTCAATGATATTATAGACTCAAACGGTCAGATTATTCTTTTCATAGATGAAATTCATTCTATTGTCAGTGCAGGACGGACAGAGGGTTCTGTTGATGCGGCCAGTATTTTGAAGCCGCTTTTGGCTAGAGGAAAAATTAGAATTATTGGTTCCACTACCCATGCAGAATACCGTGAAAGTATTGAATACGATAGGGCGTTAGAAAGACGTTTTCAAAGGATCTTAGTTCATGAACCAGATCTTGATTATACCATGGAAATTCTTAAAGGTCTCAAGCCCATTTATGAAAATTTTCATGGTGTCAGACTTGAAGAAGATGGCTTGGAAGCTGCCGCAAGCTTGTCCAAGCGTTATATTTCTGATCGCTTTTTGCCAGATAAGGCTCTGGATTTAATTGACGAAGCCTGTGCTGCTAAGCGGCTTGCTTCTCATGCTTATCCCGTGCAAATGACCAATTTGTCTCAGCAACTTATTTCTGAGAAAATTCGTTTATTGCGTTTGACCGATTCTGACACTGACGATAAGTTTAAATTAAACAATCATCTTGAGCAATTAGAGGAGCAAAAAAGCCAATTATTAGCAAATTGGCAAAGGGAAAGAGAGCTCCTAGATCAGGTACAAGAGCTTCGTTCACATTTAACGGCTTTAGAAGAGCAGGCTAATCTTGCTCTTGAAAATAATCAAGTCGCAGATTATGTCCGTCTAGAAGATGAGGAAATAAGGAAATGTCATCAAAAGATGACAGCTTTAGAAAAGGAACGTTTAGACAGTCAGAAGATAATTAATGTTACTGTGACTAGAGAAGATATAGCAGCTGTTGTTGAACGCTTGACAGGCATCAAAGTACAGGGTGTTATGGAAAACGAGCGTGATCGTCTCTTGCACTTAGAAGAATTATTGCACCAAAAAATTGTTGGTCAAGATCAAGCCGTACAAAAGGTATCTCAGGCCATCATTCGCTCTCGTGCTGGCATTCAAAACCCTAAACGTCCAATTGGCTCCTTCCTCTTTTTGGGACCGACTGGTGTGGGGAAAACAGCGCTTGCTAAACGTTTGGCGGAAGTTCTTTTTGGCAGTGAACTTGAGATGGTGCGTCTCGATATGTCTGAATATATGGAAAAACATGCTGTCTCACGTTTAGTAGGACCACCACCAGGTTATGTCGGATATGAAGAAGGAGGCCAATTAACTGAGGCTGTTCGTCAGCGTTTATACTCTATCGTCCTACTTGATGAGATTGAAAAAGCTCATCCTGATGTTTTTAATACCTTACTGCAGGTTTTAGATGAAGGGCGTTTGACGGATTCAAAAGGGCGAACCATTGATTTTAAAAATACCATCTTAATTATGACCAGCAATATTGGCTCAACCAATATTTTACAAAGTCTGCAAGATAGTGGCTGCATTACTTCAGAAGTCCGTTATAAAGTTCTAGATGAGCTGAATCACAGTTTCAGACCAGAGTTTCTTAATCGGATTGATGAGACGGTACTCTTTAATGCTCTTTCTGAAAAAGATATGACAGGTGTTGTTAAGGTCATGGTTTCTGATTTGCAAGCTCGCCTCTTAGAACAAGATATTCATCTGACATTGACTGAATCGGTTTATATCCTCTTAGCTAAAGAAGGTTTTGATGCAGCTTTTGGTGCCAGACCCATGCAGAGGACAATTATGCAAAAGTTAGAAAACCCTTTGGCTTTATATCTTATTCAAAATCAGAAAAATAAAGAAAAAGAGACTTTTGTGACAGTATCTGTTAAGGATAAGAAACTCAAATTCACATTCTCATAG","6.20","-9.20","98129","MIDKMTQLVEDSLEEAKELAIAHRNYQLDIPHLWAVLVKPDQFAFQFYQSLEINTNQLIEIINKEIDKIPVLSSTEKSSYARLYSQRLKNLLDDAHQEMIDLKDQVLTVEHLILALFNQQRNPITVFLLEQGLNKEKLYQKMHRIRKGKPAISSSQETIYDALEKYAVNLNQRALDEPVNKIIGRQDEMNDIIRILSRKNKNNAVLVGHSGVGKTAIIEGFVQRLVKNQVPKNLQGKVIYSLDIGALLAGTKYRGEFEERFKALLNDIIDSNGQIILFIDEIHSIVSAGRTEGSVDAASILKPLLARGKIRIIGSTTHAEYRESIEYDRALERRFQRILVHEPDLDYTMEILKGLKPIYENFHGVRLEEDGLEAAASLSKRYISDRFLPDKALDLIDEACAAKRLASHAYPVQMTNLSQQLISEKIRLLRLTDSDTDDKFKLNNHLEQLEEQKSQLLANWQRERELLDQVQELRSHLTALEEQANLALENNQVADYVRLEDEEIRKCHQKMTALEKERLDSQKIINVTVTREDIAAVVERLTGIKVQGVMENERDRLLHLEELLHQKIVGQDQAVQKVSQAIIRSRAGIQNPKRPIGSFLFLGPTGVGKTALAKRLAEVLFGSELEMVRLDMSEYMEKHAVSRLVGPPPGYVGYEEGGQLTEAVRQRLYSIVLLDEIEKAHPDVFNTLLQVLDEGRLTDSKGRTIDFKNTILIMTSNIGSTNILQSLQDSGCITSEVRYKVLDELNHSFRPEFLNRIDETVLFNALSEKDMTGVVKVMVSDLQARLLEQDIHLTLTESVYILLAKEGFDAAFGARPMQRTIMQKLENPLALYLIQNQKNKEKETFVTVSVKDKKLKFTFS","1354943","For other 'clp' genes see SMu0511 (clpE); SMu0861 (clpX) ; SMu0868 (clpE), (clpL); SMu1844 (clpC) and SMu1524 (clpP). For ATP-dependent Clp protease subunit X see SMu0861. For ATP-dependent Clp protease, ATP-binding subunit see SMu0868. For ATP-dependent Clp protease, proteolytic subunit see SMu1524. For ATP-dependent Clp protease, ATP-binding subunit see SMu1844. ","ATP-dependent Clp protease, ATP-binding subunit ClpB","Cytoplasm","Matches weakly to a previously published sequence from S.mutans: residues599-721 are 60% similar to a hypothetical protein 1 (Sm1) (gi|97993|) . Several matches in gapped BLAST to ClpB protein: residues 2-848 are 44% similar to the enzyme in Lactococcus lactis (gi|15673507|).Residues 2-847 are 44% similar to the protein from Listeria innocu (gi|16801373|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0488 (1e-139).","

InterPro
IPR001270
Family

Chaperonin clpA/B
PR00300	$\"[599-617]T$ $\"[644-662]T$ $\"[673-691]T$ $\"[706-720]T$	CLPPROTEASEA
PS00870	$\"[296-308]N$	CLPAB_1
PS00871	$\"[629-647]T$	CLPAB_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[200-345]T$ $\"[595-743]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[203-397]T$	AAA

InterPro
IPR004176
Domain

Clp, N-terminal
PF02861	$\"[16-67]T$ $\"[95-147]T$	Clp_N

InterPro
IPR013093
Domain

ATPase AAA-2
PF07724	$\"[594-760]T$	AAA_2

noIPR
unintegrated

unintegrated
G3DSA:1.10.1780.10	$\"[2-149]T$	G3DSA:1.10.1780.10
G3DSA:1.10.8.60	$\"[766-860]T$	G3DSA:1.10.8.60
G3DSA:3.40.50.300	$\"[159-353]T$ $\"[547-765]T$	G3DSA:3.40.50.300
PTHR11638	$\"[3-404]T$ $\"[457-696]T$	PTHR11638
PTHR11638:SF18	$\"[3-404]T$ $\"[457-696]T$	PTHR11638:SF18
SSF81923	$\"[4-146]T$	SSF81923

","BeTs to 14 clades of COG0542COG name: ATPases with chaperone activity, ATP-binding domainFunctional Class: OThe phylogenetic pattern of COG0542 is --t-YQVCEBRhUJgpOLINxNumber of proteins in this genome belonging to this COG is 4","***** IPB001270 (Chaperonins clpA/B) with a combined E-value of 2.3e-183. IPB001270A 182-224 IPB001270B 225-273 IPB001270C 275-289 IPB001270D 315-369 IPB001270E 575-629 IPB001270F 656-710 IPB001270G 749-763 IPB001270H 807-821","Residues 230-283 are 70% similar to a (PROTEASE ATP-BINDING SHOCK HEAT COMPLETE PROTEOME) protein domain (PD187342) which is seen in Q9CFF3_LACLA.Residues 2-145 are 32% similar to a (COMPLETE PROTEOME PROTEASE CLP) protein domain (PD279933) which is seen in Q9CFF3_LACLA.Residues 529-837 are 58% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9PI02_CAMJE.Residues 313-390 are 60% similar to a (PROTEASE ATP-BINDING PROTEOME COMPLETE ATP-DEPENDENT) protein domain (PD001382) which is seen in Q9X1B1_THEMA.Residues 594-697 are 66% similar to a (COMPLETE PROTEOME SECRETION TYPE PLASMID ATP-BINDING) protein domain (PD000739) which is seen in CLPB_HELPJ.Residues 2-105 are 28% similar to a (CLPB PROTEOME COMPLETE ATP-BINDING) protein domain (PD396180) which is seen in Q9RA63_THETH.Residues 391-587 are 23% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in CLPB_SYNY3.Residues 107-227 are 40% similar to a (PROTEASE ATP-BINDING COMPLETE SHOCK HEAT PROTEOME) protein domain (PD002024) which is seen in Q9RVI3_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 17:17:44 2002","Mon Mar 11 09:53:07 2002","Thu Oct 17 17:17:44 2002","Mon Mar 11 09:30:59 2002","Mon Mar 11 09:30:59 2002","Mon Mar 11 09:30:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1300 is paralogously related (blast p-value < 1e-3) to SMu0511, a predicted ATP-dependent protease ClpE; SMu0868,a predicted ATP-dependent Clp protease, ATP-binding subunit; SMu1844, a predicted ATP-dependent Clp protease, ATP-binding subunit (Class III stress response-related ATPase); and SMu1375, a predicted chromosome segregation SMC protein.","Mon Mar 11 09:57:30 2002","","No significant hits to the NCBI PDB database.","SMU.1425c","","Residues 16 to 67 (E-value = 3.5e-05) place SMu1300 in the Clp_N family which is described as Clp amino terminal domain (PF02861)Residues 95 to 147 (E-value = 4.4e-09) place SMu1300 in the Clp_N family which is described as Clp amino terminal domain (PF02861)Residues 203 to 397 (E-value = 1.7e-11) place SMu1300 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)Residues 552 to 829 (E-value = 8.5e-05) place SMu1300 in the Torsin family which is described as Torsin (PF06309)","Mon Mar 11 09:30:59 2002","","","Gottesman S, Squires C, Pichersky E, Carrington M, Hobbs M, Mattick JS, Dalrymple B, Kuramitsu H, Shiroza T, Foster T, et alConservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.Proc Natl Acad Sci U S A 1990 May;87(9):3513-7PubMed: 2185473PMID: 2185473 ","Motohashi,K., Watanabe,Y., Yohda,M. and Yoshida,M.Heat-inactivated proteins are rescued by the DnaK.J-grpE set andClpB chaperonesProc. Natl. Acad. Sci. U.S.A. 96 (13), 7184-7189 (1999)PubMed: 10377389","Tue Apr 2 18:07:12 2002","Mon Mar 11 09:53:07 2002","1","","","SMU.1425c","" "SMu1301","1359052","1357703","1350","ATGGGAAAATATTTTGGTACAGACGGCGTACGTGGTGAGGCAAATGTAGAACTAACACCGGAACTGGCTTTTAAACTTGGACGTTTTGGCGGCTATGTTCTGAGTCAGCATGAACCGGATCGCCCGCGTGTTTTCGTTGCCCGTGATACTCGCATTTCTGGAGAATTGTTAGAATCAGCTCTTGTTGCTGGATTGCTTTCTGTTGGTATTGAAGTCTATAAACTAGGTGTTCTGGCAACACCGGGGGTTTCTTATTTAGTGCGTACTGAACAAGCCAGTGCAGGTGTCATGATATCTGCTAGTCACAATCCTGCGCTTGATAATGGTATCAAATTCTTTGGTGGTGATGGCTTTAAATTAGCTGATGAACAAGAAGCAGAAATTGAAGCTTTATTAGATGCTAAAGAAGATGACTTACCCCGTCCTTCAGCTCAAGGATTGGGAATGGTCGTTGATTATCCAGAAGGACTTCGTAAATACGAAAAGTTCTTAGTGTCAACAGGCTCAGACCTTGAAGGAATGAAAATTGCTATTGATGCAGCAAATGGTGCTGCATCTTACTCAGCCCGCCAAGTTTTCCTTGATTTGAACGCTGATATCACTGTTATTGGCGAGGAGCCGGATGGTCTCAATATTAATGATGGGGTAGGATCTACTCATCCTGAGCAACTTCAAAATCTTGTTAAGGGATCTGATTTTGTTATTGGCCTTGCTTTTGATGGCGATAGTGATCGTTTGATCGCTGTTGATGAGAATGGTGAAATTGTTGATGGTGATAAGATTATGTATATTATTGGCAAGTATCTTTCTGAAAAAGGAAGGCTGTCTAAAAATACGATCGTCACAACCGTTATGTCAAATCTCGGCTTCCATAAAGCTTTGGATCGTGAGAATATTAACAAAAAAATCACAGCAGTAGGTGATCGTTATGTTGTTGAGGAAATGCGACGTTCGGGCTATAATCTCGGCGGTGAGCAATCTGGTCATGTGATTATTATGGACTATAACACAACAGGTGATGGTCAGCTGACAGCTATTCAATTGACCAAAGTGATGAAAGAAACAGGTAAAACTTTGTCTGAATTGGCCAATGAAGTGACGATTTATCCACAGAAATTAGTTAATATTTATGTTAAAAATGACATGAAAAATAAGGCTATGGAAGTGCCAATGATTGCACAAATCATTGAAAAAATGGAAGCTGAGATGGCTGGCAATGGTCGCATTCTGGTTCGTCCAAGTGGAACAGAGCCCCTCTTGCGTGTTATGGCAGAAGCACCTAGTACAGAAGAGGTCAATTATTATGTAGATACCATTGCCAAAGTTGTCAAAACAGAAATTGGCATTTAA","4.60","-19.74","48699","MGKYFGTDGVRGEANVELTPELAFKLGRFGGYVLSQHEPDRPRVFVARDTRISGELLESALVAGLLSVGIEVYKLGVLATPGVSYLVRTEQASAGVMISASHNPALDNGIKFFGGDGFKLADEQEAEIEALLDAKEDDLPRPSAQGLGMVVDYPEGLRKYEKFLVSTGSDLEGMKIAIDAANGAASYSARQVFLDLNADITVIGEEPDGLNINDGVGSTHPEQLQNLVKGSDFVIGLAFDGDSDRLIAVDENGEIVDGDKIMYIIGKYLSEKGRLSKNTIVTTVMSNLGFHKALDRENINKKITAVGDRYVVEEMRRSGYNLGGEQSGHVIIMDYNTTGDGQLTAIQLTKVMKETGKTLSELANEVTIYPQKLVNIYVKNDMKNKAMEVPMIAQIIEKMEAEMAGNGRILVRPSGTEPLLRVMAEAPSTEEVNYYVDTIAKVVKTEIGI","1357718","For other 'glm' genes see SMu1086 (glmS) and SMu1488 (glmU). ","phosphoglucosamine mutase (phosphoacetylglucosamine mutase)","Cytoplasm","Several matches in gapped BLAST to phosphosugarmutase: residues 1-448 are 85% similar to the enzyme in S.pyogenes (gi15675035) and residues 1-449 are 84% similar to the protein from S.pneumoniae (gi15901402). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0887 (0.0).","

InterPro
IPR005841
Family

Phosphoglucomutase/phosphomannomutase
PR00509	$\"[94-108]T$ $\"[173-192]T$ $\"[233-248]T$	PGMPMM
PS00710	$\"[95-104]T$	PGM_PMM

InterPro
IPR005843
Domain

Phosphoglucomutase/phosphomannomutase C-terminal
PF00408	$\"[404-445]T$	PGM_PMM_IV

InterPro
IPR005844
Domain

Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I
PF02878	$\"[2-139]T$	PGM_PMM_I

InterPro
IPR005845
Domain

Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II
PF02879	$\"[158-255]T$	PGM_PMM_II

InterPro
IPR005846
Domain

Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III
PF02880	$\"[257-369]T$	PGM_PMM_III

InterPro
IPR006352
Family

Phosphoglucosamine mutase
TIGR01455	$\"[5-445]T$	glmM

noIPR
unintegrated

unintegrated
G3DSA:3.40.120.10	$\"[4-135]T$ $\"[175-249]T$ $\"[250-367]T$	G3DSA:3.40.120.10
PTHR22573	$\"[61-448]T$	PTHR22573
PTHR22573:SF2	$\"[61-448]T$	PTHR22573:SF2
SSF53738	$\"[257-366]T$	SSF53738
SSF55957	$\"[366-448]T$	SSF55957

","BeTs to 17 clades of COG1109COG name: PhosphomannomutaseFunctional Class: GThe phylogenetic pattern of COG1109 is aMTKYQVCEBRHUJgpOLINxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 10-127 are 71% similar to a (PHOSPHOMANNOMUTASE PHOSPHOGLUCOMUTASE ISOMERASE COMPLETE) protein domain (PD000667) which is seen in Q9KG46_BACHD.Residues 346-405 are 43% similar to a (PROTEOME COMPLETE YBBT PHOSPHOGLUCOSAMINE) protein domain (PD330870) which is seen in P95685_STAAU.Residues 214-355 are 49% similar to a (PHOSPHOGLUCOMUTASE COMPLETE PROTEOME ISOMERASE) protein domain (PD344757) which is seen in O06258_MYCTU.Residues 370-448 are 67% similar to a (PHOSPHOMANNOMUTASE COMPLETE PROTEOME PHOSPHORYLATION) protein domain (PD001709) which is seen in Q9CID9_LACLA.Residues 147-213 are 61% similar to a (PROTEOME COMPLETE PHOSPHORYLATION MUTASE) protein domain (PD116462) which is seen in Q9CID9_LACLA.Residues 208-344 are 64% similar to a (PHOSPHOMANNOMUTASE COMPLETE PROTEOME ISOMERASE) protein domain (PD000778) which is seen in P95685_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 08:56:41 2006","Wed Oct 23 17:53:08 2002","Thu Aug 3 08:56:41 2006","Mon Mar 11 10:04:18 2002","","Mon Mar 11 10:04:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1301 is paralogously related (blast p-value < 1e-3) to SMu0985, also a phosphoglucomutase.","Mon Mar 11 10:25:41 2002","","No significant hits to the NCBI PDB database.","SMU.1426c","","Residues 2 to 139 (E-value = 2.4e-56) place SMu1301 in the PGM_PMM_I family which is described as Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I (PF02878)Residues 158 to 255 (E-value = 3.6e-24) place SMu1301 in the PGM_PMM_II family which is described as Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II (PF02879)Residues 257 to 369 (E-value = 6.5e-25) place SMu1301 in the PGM_PMM_III family which is described as Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III (PF02880)Residues 373 to 445 (E-value = 4.7e-06) place SMu1301 in the PGM_PMM_IV family which is described as Phosphoglucomutase/phosphomannomutase, C-terminal domain (PF00408)","Thu Aug 3 08:56:41 2006","24379829","","","Levander,F. and Radstrom,P. Requirement for Phosphoglucomutase in Exopolysaccharide Biosynthesis in Glucose- and Lactose-Utilizing Streptococcus thermophilus Appl. Environ. Microbiol. 67 (6), 2734-2738 (2001) PubMed: 11375188 Hardy,G.G., Caimano,M.J. and Yother,J. Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase J. Bacteriol. 182 (7), 1854-1863 (2000) PubMed: 10714989 ","","Mon Mar 11 10:25:41 2002","1","","","SMU.1426c","106" "SMu1302","1360059","1359103","957","ATGTTTAAGCGGTTTTTTACTAAACGTCTCTGGTTAACTCTTGTTTCAATCTTTTTTGCCATTCTCTTGTTCTTGACAGCTAATTCAGTCAATTATGGTTCAAGAAATCAAACAACTGGCCTTTTGCAGACATACAACCATACCTTAGAAAATGTCCCTATTGATATTAAATATGACAGCAATAAGTACTTCATTAGTGGTTATTCTTATGATACAGAGGTTTATTTGACCTCAACCAATCGGGTAAAATTGGATTCAGAAATCAATAATGACACCAGACATTTTAAAGTTGTTGCTGACTTGTCAAATGCTAAAGAAGGTACCAATAAGGTTCCTTTGGAGATAAAAGATCTTCCTAGTGGTGTCAGCGCAGAAGCTTCACCGACGACTATAAATGTGACCGTTGGTAAAAAGAAAACAAAGACGTTTAAAGTTGTTGGTAAAGTATCTGATAATCAAATTGCTGATGGTTACAAATTAAAGAAAATTTCTACTAGTGCTTCAGAGGTAGAGGTTACTAGCGATGAGTCCACTATTGAGCAGATTGATCATGTAGTAGCTGTTCTTCCGGAGAATCAAGTCCTATCCAAAGATTACAGCGGTTCAGTAACCTTACAGGCTGTTTCTGAAAACGGTAAAATTTTACCAAGTATTATTGATCCAACAAAAACAGACTTAGAGGTTGAGGTTGAAGAATTGTCAAAAAAAGTACCGATTATTGTTGAGTTAACAGGTCAAATTAACAGCAGTCTGTCTGATATTCGCTACGAATTAGCGACAAAAGAAGTTCTTATCTATGGTAAACAAGAAAATCTCGAAAAAATATCTTACATTAAGGCTAAAGTTAATATTTCAGATGTTACTAAGGATACAACAAAGACAATTCCTTTAGCTGCGGATAATCTTAAGATAAGTCCTGCAAAAGTAACTGTTAAGTTGACAGCTAAGAAAAAATAA","9.50","3.74","35266","MFKRFFTKRLWLTLVSIFFAILLFLTANSVNYGSRNQTTGLLQTYNHTLENVPIDIKYDSNKYFISGYSYDTEVYLTSTNRVKLDSEINNDTRHFKVVADLSNAKEGTNKVPLEIKDLPSGVSAEASPTTINVTVGKKKTKTFKVVGKVSDNQIADGYKLKKISTSASEVEVTSDESTIEQIDHVVAVLPENQVLSKDYSGSVTLQAVSENGKILPSIIDPTKTDLEVEVEELSKKVPIIVELTGQINSSLSDIRYELATKEVLIYGKQENLEKISYIKAKVNISDVTKDTTKTIPLAADNLKISPAKVTVKLTAKKK","1359118","","conserved hypothetical protein","Membrane, Cytoplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 3-306 are 53% similar to S.pyogenes (gi|15675034|) and residues 16-224 are 40% similar to S.pneumoniae (gi|15903461|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0886 (3e-80).","

InterPro
IPR012505
Family

YbbR-like
PF07949	$\"[52-135]T$ $\"[143-228]T$ $\"[237-313]T$	YbbR

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-222 are 23% similar to a (PROTEOME COMPLETE YBBR BH0266) protein domain (PD155863) which is seen in O87088_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 10:20:09 2002","Mon Mar 11 10:20:09 2002","Mon Mar 11 10:20:09 2002","Mon Mar 11 10:20:09 2002","","Mon Mar 11 10:20:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1302 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 10:20:09 2002","","No significant hits to the NCBI PDB database.","SMU.1427c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 10:20:09 2002","24379830","","","","","","1","","","SMU.1427c","669" "SMu1303","1360906","1360052","855","ATGAGTAGTTTATTTAACGTTAATGCCCAATTTTGGGCTAGTCTTATTGATAGTCCTTTAAAAATTTTAGTTCATATTCTTGATATTGCTATTGTATCATGGTTGATTTATAAATTTATCAAAGCCTTAGCAGGTACTAAAGTGATGTCTTTAGTTCAAGGAGTTGTTCTATTTGTTCTCTTTAAATTTGTCGCAGAATTCTTAGGATTCACAACAATTGCTTTTTTGATGAACCAAGTTATTACTTATGGTGTTATTGCCGGAGTTGTTATCTTTGCTCCTGAAATTCGGTCTGGCTTGGAACGTTTTGGACGAACACCCCAGTCTTTTATCCAAAGACAGCAGCTGAGTGATGATGAAAAATTAGTTGCCGCCTTTGTGAAAGCTGTGGCTTATATGAGTCCGCGCAAAATTGGAGCTTTGGTATCAATAGAAGAGACTCAGACCCTAAGAGAATATATTGCCACTGGAATTCCTTTAGATGCAGATATTTCTGGAGAATTACTGATTAATATTTTTATTCCTAATACACCTTTGCACGATGGTGCCGTTATTGTGGAGGGAAATAAGATTGCTGTTTCTTGTGCCTATCTTCCGCTTTCAGAGTCCAGTCATATTTCCAAGGAATTTGGAACGCGCCACCGTGCTGCCATTGGACTTTCAGAAGCTTCTGATGCCTTTACCTTTGTTGTTTCCGAGGAAACAGGAGCTATTTCTGTTGCTTACAAAGGTGATTTTATCCATGATTTGTCCCTTGAAGCTTTTGAGGTCTTATTGCGGGAGCATTTCATTAAAGAAGAACCAAAGAAAAAGAATTGGATGAAGCAATTCTTTGGAGGACGCCATCATGTTTAA","6.70","-1.11","31498","MSSLFNVNAQFWASLIDSPLKILVHILDIAIVSWLIYKFIKALAGTKVMSLVQGVVLFVLFKFVAEFLGFTTIAFLMNQVITYGVIAGVVIFAPEIRSGLERFGRTPQSFIQRQQLSDDEKLVAAFVKAVAYMSPRKIGALVSIEETQTLREYIATGIPLDADISGELLINIFIPNTPLHDGAVIVEGNKIAVSCAYLPLSESSHISKEFGTRHRAAIGLSEASDAFTFVVSEETGAISVAYKGDFIHDLSLEAFEVLLREHFIKEEPKKKNWMKQFFGGRHHV","1360067","","conserved hypothetical protein","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins: residues 1-281 are 65% similar to S.pyogenes (gi|15675033|) and residues 8-283 are 59% similar to S.pneumoniae (gi|15903462|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0885 (1e-112).","

InterPro
IPR003390
Domain

Protein of unknown function DUF147
PF02457	$\"[126-247]T$	DUF147

InterPro
IPR014046
Family

Conserved hypothetical protein CHP00159
PIRSF004793	$\"[15-277]T$	UCP004793
TIGR00159	$\"[12-267]T$	CHP00159

","BeTs to 8 clades of COG1624COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1624 is am-k-q-c-B----gpolin-Number of proteins in this genome belonging to this COG is 1","***** IPB003390 (Domain of unknown function DUF147) with a combined E-value of 8.3e-23. IPB003390A 172-177 IPB003390B 181-188 IPB003390C 211-240","Residues 133-244 are 75% similar to a (PROTEOME COMPLETE MG105 TRANSMEMBRANE) protein domain (PD006844) which is seen in Q9CIE0_LACLA.Residues 27-105 are 55% similar to a (PROTEOME COMPLETE BH0265 YEDA) protein domain (PD190476) which is seen in Q9CIE0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 10:23:37 2002","Mon Mar 11 10:23:37 2002","Mon Mar 11 10:23:37 2002","Mon Mar 11 10:23:37 2002","Mon Mar 11 10:23:37 2002","Mon Mar 11 10:23:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1303 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 10:23:37 2002","","No significant hits to the NCBI PDB database.","SMU.1428c","","Residues 126 to 247 (E-value = 2.4e-56) place SMu1303 in the DUF147 family which is described as Domain of unknown function DUF147 (PF02457)","Mon Mar 11 10:23:37 2002","24379831","","","","","","1","","","SMU.1428c","339" "SMu1304","1361015","1362358","1344","ATGACTTTAAAATCAAGAATAGGAATTTTAGCTGGTAAGACAGCACACTTTTTTCTCAGTAAAATAGGGCGCGGCTCTACCTTACCTGGAAAAATTGCTCTTAAGTGCGATAAAGATATTTTAGATACACTTGCTAAAGATTATGACATTGTTGTTGTCACAGGCACTAATGGAAAAACCTTAACAACAGCTTTAACAGTAGGAATTTTAAAAGAGGCTTACGGTCAGGTGCTAACCAATCCTAGTGGTGCCAATATGATTACAGGAATTACCTCAACTTTTTTAACTGCTAAAAAATCTAGAAATGGTAAAAAGATTGCGGTGCTGGAGATTGATGAAGCCAGCCTTCCTAAAATTACAGATTATCTAAAGCCCAGCCTTTTTGTTTTCACCAATATTTTTCGTGATCAAATGGATCGTTACGGTGAAATTTATACTACCTATCAAATGATTTTGGACGGTGCTGCCAAAGCGCCAAAAGCAACTATTTTAGCTAATGGCGATAGCCCACTCTTTAACGCCAAAACAGTTGTTAATCCTGTGCGTTACTATGGTTTTGATACAAAAAAAGAAGCTGCTCACTTGGCACATTACAATACTGAAGGCATCGTCTGTCCTAAGTGCGAATATATCCTACAATACAAGCTTAATACTTATGCCAACTTGGGCGACTACATCTGCCCCAACTGTGGTTTTCACCGTCCTCATCTGGATTACAGCTTGACTCAGCTAACCAAGATTAGCAACACTCAAGCTGAGTTCATCATTGACGGACAGGATTATAAGATCAATGTCGGCGGCCTTTATAATATCTATAATGCCTTGGCTGCAGTCGCTGTTGCAGAATTTCTCGGTGTAACTCCTGAACAAATCAAGGCTGGCTTTGACAAGAGCCGTGCTGTTTTTGGACGCCAAGAAACCTTTAAAATCGGCGATAAGTCATGTACTCTTGTTTTAATAAAAAATCCTGTTGGTGCCAGTCAAGCACTAGAAATGATTAAACTAGCACCTTATCCTTTCACCTTATCTGTCCTTCTCAATGCCAATTATGCTGATGGCATTGATACCAGCTGGATTTGGGATGCGAATTTTGAGAGCATTTTAGATATGAATATTCCACAAATCTTTACAGGTGGTGTCCGCCATTCAGAAATAGCCAGACGTCTGCGTGTTACTGGTTACAATGAAACAAAGATTGAGCAGGCTGAAAAACTTGAAGACATTCTAAGTATGATTGAAAAACAAGAGGCTGATCATGCCTACATTCTAGCTACTTACACAGCCATGTTGGAATTCCGCGAATTACTAGCCAGCCGTCACGCAGTAAGAAAGGAGATGCATTAA","8.20","4.90","49570","MTLKSRIGILAGKTAHFFLSKIGRGSTLPGKIALKCDKDILDTLAKDYDIVVVTGTNGKTLTTALTVGILKEAYGQVLTNPSGANMITGITSTFLTAKKSRNGKKIAVLEIDEASLPKITDYLKPSLFVFTNIFRDQMDRYGEIYTTYQMILDGAAKAPKATILANGDSPLFNAKTVVNPVRYYGFDTKKEAAHLAHYNTEGIVCPKCEYILQYKLNTYANLGDYICPNCGFHRPHLDYSLTQLTKISNTQAEFIIDGQDYKINVGGLYNIYNALAAVAVAEFLGVTPEQIKAGFDKSRAVFGRQETFKIGDKSCTLVLIKNPVGASQALEMIKLAPYPFTLSVLLNANYADGIDTSWIWDANFESILDMNIPQIFTGGVRHSEIARRLRVTGYNETKIEQAEKLEDILSMIEKQEADHAYILATYTAMLEFRELLASRHAVRKEMH","1362367","For other 'mur' genes see SMu0549 (murF); SMu0653 (murN); SMu0654 (murM); SMu0883 (murB); SMu1529 (murE); SMu1566 (murI);SMu0498 (murD); SMu0499 (murG); SMu1577 (murC);SMu1386 (murA) and SMu1429 (murZ).","UDP-N-acetylmuramyl tripeptide synthetase","Cytoplasm","Limited matches in gapped BLAST to UDP-N-acetylmuramyl tripeptide synthetase: residues 3-446 are 78% similar to the enzyme from S.pyogenes (gi15675032) and residues 1-447 are 73% similar to the enzyme from S.pneumoniae (gi15901431).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0884 (0.0).","

InterPro
IPR013221
Domain

Mur ligase, middle region
PF08245	$\"[51-281]T$	Mur_ligase_M

InterPro
IPR013564
Domain

Domain of unknown function DUF1727
PF08353	$\"[319-429]T$	DUF1727

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.10	$\"[37-295]T$	G3DSA:3.40.1190.10
PTHR23135	$\"[53-200]T$ $\"[249-319]T$	PTHR23135
PTHR23135:SF4	$\"[53-200]T$ $\"[249-319]T$	PTHR23135:SF4
SSF53623	$\"[37-299]T$	SSF53623

","BeTs to 4 clades of COG0769COG name: UDP-N-acetylmuramyl tripeptide synthaseFunctional Class: MThe phylogenetic pattern of COG0769 is --T--qvCebRhuj--olinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 116-291 are 71% similar to a (PROTEOME COMPLETE YLBD) protein domain (PD415770) which is seen in Q9CGJ0_LACLA.Residues 51-118 are 44% similar to a (LIGASE PROTEOME COMPLETE POSSIBLE) protein domain (PD388417) which is seen in O69522_MYCLE.Residues 37-113 are 71% similar to a (LIGASE CELL SYNTHETASE PEPTIDOGLYCAN SYNTHESIS) protein domain (PD001083) which is seen in Q9CGJ0_LACLA.Residues 293-440 are 67% similar to a (PROTEOME LIGASE COMPLETE) protein domain (PD039281) which is seen in Q9CGJ0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 3 08:50:14 2006","Mon Mar 11 10:29:53 2002","Thu Aug 3 08:50:14 2006","Mon Mar 11 10:29:53 2002","","Mon Mar 11 10:29:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1304 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 09:14:10 2002","","No significant hits to the NCBI PDB database.","SMU.1429","","Residues 6 to 292 (E-value = 9.9e-07) place SMu1304 in the Mur_ligase family which is described as Mur ligase family, catalytic domain (PF01225)","Mon Mar 11 10:29:53 2002","24379832","","","","","","1","","","SMU.1429","105" "SMu1305","1362358","1363146","789","ATGACTTATACTTCTCTACAATCTCCTGCTGACAAGGATTACTTATATGATATCAGGGTTGCTCATCTTTATGGCAATTTGCTCAATACCTATGGCGATAACGGAAACGTTCTCATGCTTAAATATGTTGGTGAAAAATTAGGTATACGAATGACTTTTGATATTGTCTCAATCGGCGATGATTTTGATGCTAACAAGTATGATATGGTTTTCTTTGGCGGCGGTCAGGACTATGAGCAATCCATTGTTGCTAAGGATTTGCCTAATAAACGCTCTGCTATTGCCAGCTTTATTCAAAATAATAAGGTTGTCCTAGCTATCTGCGGCGGTTTCCAGTTGTTGGGACAATATTATGTTCAAGCCAATGGCGTCCGCATTGACGGTATTGGTGTTATGGGGCACTATACGCTTAATCAAAAAGATAATCGCTACATTGGTGATATCAAGATTCATAATGATGAATTTAACGAAACCTACTACGGCTTTGAGAATCATCAAGGAAGAACCTTTTTGTCTGATGACGAAAAGCCTTTAGGGAGAGTTATTTATGGAAATGGTAATAATAAAGAGGATGGCAGTGAAGGCGTCCACTATAAAAATGTTTTTGGCTCCTACTTCCACGGTCCCATTCTTTCGCGTAATGCTAATCTAGCTTACCGCCTTGTGACAACAGCTCTACATAACAAGTATGGCATTGATATTCAACTACCTCGTTATGAGGACATTCTTAGCTTAGAGGTTGCTGAAGAATACGGCGATGTTAAAAGCAAAGCGGAGTTTGAGAAATAG","5.20","-7.36","29604","MTYTSLQSPADKDYLYDIRVAHLYGNLLNTYGDNGNVLMLKYVGEKLGIRMTFDIVSIGDDFDANKYDMVFFGGGQDYEQSIVAKDLPNKRSAIASFIQNNKVVLAICGGFQLLGQYYVQANGVRIDGIGVMGHYTLNQKDNRYIGDIKIHNDEFNETYYGFENHQGRTFLSDDEKPLGRVIYGNGNNKEDGSEGVHYKNVFGSYFHGPILSRNANLAYRLVTTALHNKYGIDIQLPRYEDILSLEVAEEYGDVKSKAEFEK","1363155","","cobyric acid synthase","Cytoplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical proteins and cobyric acid synthase: residues 1-262 are 79% similar to S.pyogenes (gi|15675031|) and residues 1-260 are 76% similar to S.pneumoniae (gi|15903487|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0883 (1e-130).","

InterPro
IPR011698
Domain

CobB/CobQ-like glutamine amidotransferase
PF07685	$\"[60-215]T$	GATase_3

noIPR
unintegrated

unintegrated
SSF52317	$\"[27-207]T$	SSF52317

","BeTs to 3 clades of COG1492COG name: Cobyric acid synthase CbiP/CobQFunctional Class: HThe phylogenetic pattern of COG1492 is amT----c--r----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 26-223 are 64% similar to a (BIOSYNTHESIS SYNTHASE ACID COBYRINIC) protein domain (PD183660) which is seen in Q9CGJ1_LACLA.Residues 137-233 are 37% similar to a (BIOSYNTHESIS ACID SYNTHASE COBYRIC) protein domain (PD002914) which is seen in COBQ_METTH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 10:41:47 2002","Mon Mar 11 10:36:03 2002","Thu Oct 17 17:15:15 2002","Mon Mar 11 10:36:03 2002","","Mon Mar 11 10:36:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1305 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 10:36:03 2002","","No significant hits to the NCBI PDB database.","SMU.1430","","No significant hits to the Pfam 11.0 database","Mon Mar 11 10:36:03 2002","24379833","","","","","","1","","","SMU.1430","338" "SMu1306","1365303","1363390","1914","ATGATTATTTTACAGGGAAACAAATTAGAGCGCTCATTTTCTGGTGATGTGCTCTTTGATAATATTAATCTTCAAGTAGATGAACATGATCGTATCGCCTTGGTTGGACCTAATGGTGCTGGTAAGTCTACACTCTTAAAAATTCTCGTGGGTGAAGAAACAGCAACATCAGGTGAGGTCACTCTCAAGCGTGATGTAACCCTGTCGTATTTGGCTCAGAATAGCCGTTTTAAATCTGATAATACCATTTATGATGAAATGCTCCATGTTTTTGATGATTTACGTGCGACTGAGAGACATTTGCGCTCTATGGAAGGGCAAATGGCAGAGTTGGTCGGAAATGATTTTGATAAACTCATGGCTGATTATGACCGCTTATCCGAATCCTTCAGGCAGCAGGGTGGTTTCACTTATGAGAGTGACATCAAAGCTATTCTCAATGGTTTTAAATTTGATGAGTCTATGTGGCAGACGAAAATTGCTGAACTCTCAGGCGGTCAAAACACGCGCCTAGCTTTGGCCAAGATGCTTCTAGAAAAACCAGAACTGTTGGTATTGGACGAGCCCACCAATCATTTGGATATTGAAACCATTTCTTGGTTGGAAAATTATTTAGTCAATTATCAAGGAGCTTTAATCATTGTTAGTCATGACCGTTATTTTCTTGATAAGGTAGCGACAGTTACGCTTGATTTGACCCCTCACTCTCTAGATCGCTATGTGGGAAATTATTCCAAATTCATGGATCTTAAGGCTGAAAAAATTGCCATGAAAGAGAAAAATTATGAGAAGCAGCAAAAAGAAATTGCTAAATTAGAGGACTTTGTGCAGCGCAATATTGTTCGTGCATCAACGACCAAGCGGGCACAGGCTAGGCGTAAGCAATTGGAAAAAATGGAGCGATTGGATAAACCCGATGCCAGTAAAAAATCTGCCAATATGACTTTTCATGTTGATAAAGCCTCCGGAAATGAGGTTTTAAAGGTTACTGATGCAGCTATTGGTTATGATGACAAGATATTAGCGCAGCCTATTGATCTAGATGTTAGAAAAATGGATGCCCTTGCTATCGTCGGTCCCAATGGTATTGGCAAATCAACCTTGCTCAAGTCCATTATGGGGCAAATACCATTTATTCATGGGAGCTCAGTTTATGGCTCAAATGTACAAGTCGGTTATTATGACCAGACCCAATCCAATCTGACAGCTAGCAATACCGTTTTAGAAGAGCTTTGGTCAGCCTTTCCAAGGACAGCAGAAGTGGATATTAGAAACCGTTTAGGTGCTTTTCTCTTTTCAGGCGACGATGTCAAAAAATCTGTTGCCATGCTGTCTGGTGGTGAACGCGCGCGCTTGCTTCTTGCCAAGTTATCCATGGAAAACAATAATTTTCTCATTCTAGACGAACCTACTAATCACTTAGATATTGACAGTAAGGAAGTGTTGGAGACTGCTCTTATTGATTTTGATGGCACTCTTCTCTTTGTTAGCCACGACCGTTATTTCATCAACCGCGTCGCGACAAAAGTTCTCGAAATCTCCCAAAATGGTTCCACCCTTTACTTAGGTGATTACGATTATTATCTTGAAAAAAAAGCAGAGCGAGAAGCAAAGACAGAGTTCCTTCAACCTATGCAGTCAGGATCCCCTTCATCCTCCTTGGCTGCCGCCACGAACTATCAAGCCCAAAAGGCCAACCAAAAAGAAGAACGCAAATTAAAGAGGCGTATAGCCGAAATTGAAGAGCGTTTAGAAACCATTGAAGCGCGTGAAACTGAAATTAATGAGGCCATGCTTACTACTAATGACTTTACTCAATTGGCCGACCTGCAAAAAGAACTAGAAAGCGTTCAAACAGAACAATTGGAACTTCTAGAAGAATGGGAAGAATTGAGTAGGCAGCTGGAGGATTGA","4.80","-24.49","72227","MIILQGNKLERSFSGDVLFDNINLQVDEHDRIALVGPNGAGKSTLLKILVGEETATSGEVTLKRDVTLSYLAQNSRFKSDNTIYDEMLHVFDDLRATERHLRSMEGQMAELVGNDFDKLMADYDRLSESFRQQGGFTYESDIKAILNGFKFDESMWQTKIAELSGGQNTRLALAKMLLEKPELLVLDEPTNHLDIETISWLENYLVNYQGALIIVSHDRYFLDKVATVTLDLTPHSLDRYVGNYSKFMDLKAEKIAMKEKNYEKQQKEIAKLEDFVQRNIVRASTTKRAQARRKQLEKMERLDKPDASKKSANMTFHVDKASGNEVLKVTDAAIGYDDKILAQPIDLDVRKMDALAIVGPNGIGKSTLLKSIMGQIPFIHGSSVYGSNVQVGYYDQTQSNLTASNTVLEELWSAFPRTAEVDIRNRLGAFLFSGDDVKKSVAMLSGGERARLLLAKLSMENNNFLILDEPTNHLDIDSKEVLETALIDFDGTLLFVSHDRYFINRVATKVLEISQNGSTLYLGDYDYYLEKKAEREAKTEFLQPMQSGSPSSSLAAATNYQAQKANQKEERKLKRRIAEIEERLETIEARETEINEAMLTTNDFTQLADLQKELESVQTEQLELLEEWEELSRQLED","1363405","This sequence contains two nucleotide binding domains.","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Several hits in gapped BLAST to ABC ATP-binding proteins. Residues 1-612 are 76% similar to gi|15675024| from S.pyogenes andresidues 1-611 are 75% similar to gi|15900981| from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0877 (0.0).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[162-205]T$ $\"[444-486]T$	ABC_transporter
PF00005	$\"[31-235]T$ $\"[354-517]T$	ABC_tran
PS00211	$\"[444-458]?$	ABC_TRANSPORTER_1
PS50893	$\"[4-260]T$ $\"[327-541]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-243]T$ $\"[351-517]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-282]T$ $\"[289-532]T$	G3DSA:3.40.50.300
PTHR19211	$\"[133-614]T$	PTHR19211
PTHR19211:SF11	$\"[133-614]T$	PTHR19211:SF11
SSF52540	$\"[6-246]T$ $\"[327-593]T$	SSF52540

InterPro
IPR002037
Family

Glycoside hydrolase, family 8
PR00735	$\"[55-73]T$ $\"[161-172]T$ $\"[192-201]T$ $\"[282-295]T$	GLHYDRLASE8
PF01270	$\"[18-200]T$	Glyco_hydro_8
PS00812	$\"[55-73]T$	GLYCOSYL_HYDROL_F8

InterPro
IPR008928
Domain

Six-hairpin glycosidase-like
SSF48208	$\"[1-293]T$	Glyco_trans_6hp

InterPro
IPR012341
Domain

Six-hairpin glycosidase
G3DSA:1.50.10.10	$\"[1-293]T$	CelA/Cel48F_cat

","No hits to the COGs database.","***** IPB002037 (Glycoside hydrolase family 8) with a combined E-value of 2.7e-11. IPB002037A 53-73","Residues 32-200 are 32% similar to a (ENDOGLUCANASE HYDROLASE GLYCOSIDASE) protein domain (PD006417) which is seen in GUN_BACSP.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 22 08:44:20 2002","Wed Sep 27 13:40:59 2006","Wed Sep 27 13:28:02 2006","Fri Mar 22 08:42:22 2002","Fri Mar 22 08:42:22 2002","Fri Mar 22 08:42:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1307 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 22 08:44:20 2002","Wed Sep 27 13:28:02 2006","pdb1CEM Endoglucanase A (Cela) Catalytic Core, Residues 33... 77 3e-015","SMU.1432c","","Residues 1 to 295 (E-value = 2.9e-09) place SMu1307 in the Glyco_hydro_8 family which is described as Glycosyl hydrolases family 8 (PF01270)","Fri Mar 22 08:42:22 2002","24379835","","","Alzari,P.M., Souchon,H. and Dominguez,R.The crystal structure of endoglucanase CelA, a family 8 glycosylhydrolase from Clostridium thermocellumStructure 4 (3), 265-275 (1996)PubMed: 8805535Ozaki,K., Sumitomo,N. and Ito,S.Molecular cloning and nucleotide sequence of the gene encoding anendo-1,4-beta-glucanase from Bacillus sp. KSM-330J. Gen. Microbiol. 137 (Pt 10), 2299-2305 (1991)PubMed: 1770347","","Fri Mar 22 08:44:20 2002","1","","","SMU.1432c","" "SMu1308","1367669","1366506","1164","ATGGTGACAGTTGTGGTTCCAGCTCATAATGAAGATGTTGTGATTGCACAAACAGCAAAGGCTATTTTGGATATGAAGTACCCAAGGGATAAGCTTGAAATTATTCTTTTTGCTGATAACTGTGAAGATAATACGTATCAGGAAATGCAAAGCATTAAAGCTTTGCCGCAATATGCTGATCGAGATTTGACTCTGATTAATCGTAGTGGTACTGGTGGAAAAGCTGGTGTCTTAAATGATGCTTTGAAGATAGCTAAAGGTGATTATATCTGTGTTTATGATGCGGATGCCATGCCTGAAAAAAATGCTCTTTATTTCCTTGTTCAAAAGGTTATGGAAGATCCAGAACGTCATGTAGCAGCTTTTGGTCGAAATAAGACGCGTAATGCTAATCAAAACTTCCTGACTCGTTGTATTAATCAGGAAATCGTTGTTACCCAACGTATCCAACATGTTGGTATGTGGCATTTGGGAAAAATTGGACGGATTCCTGGTACCAACTTTATTATCAATACGGAATTTGTTAAGAGTATTGGCGGCTGGAGAAATGGTGCCCTGACAGAAGATACGGATATCTCCTTTAAAATCATGCAAAGTGGTAAGTTGATTGCCCTTGCCTATAATTCAGAAGCTTTCCAGCAAGAACCCGAAACGCTGAAATCTTATTATTTGCAAAGAAAGCGCTGGGCTAAAGGTAACTATGAGGTTGTTATTGCTAACTTTAAACACCTTTTTGGCCGTGGTAATTGGCGTGTCAAATGGGAAGTCTTCTACTATACTTGTACTTTCTTTTGGTTTAATGCAGCCATTGTGTTATCAGATATCTTATTTTTTTCCAATTTGATTGCATTAATTATTGGTCTATTTAAGCCAGGTGTGCAGGTTCCCTTTGCTTTTGATGCTAATAATATTTACATGGCACAGCTTTTGCTCTTTAACTGGTTCTTAATGATTTTGCTTTATCTCTTGCAAATTTCCATTTCACAGGCGACTCAATATGGTCAGGCAACCGTTAAACAAATTTGGATTGCCTTATTGGCTTACTTTACTTATACGCAGCTCTTTATTATTGTATCCATTTCATCAGTAGCTTCTGTTATGATGGATAAGATTTTACATCGTGAAGGAACCAAATGGGTTAAAACAAAACGTTTTGCAGGCTAG","9.80","9.26","44281","MVTVVVPAHNEDVVIAQTAKAILDMKYPRDKLEIILFADNCEDNTYQEMQSIKALPQYADRDLTLINRSGTGGKAGVLNDALKIAKGDYICVYDADAMPEKNALYFLVQKVMEDPERHVAAFGRNKTRNANQNFLTRCINQEIVVTQRIQHVGMWHLGKIGRIPGTNFIINTEFVKSIGGWRNGALTEDTDISFKIMQSGKLIALAYNSEAFQQEPETLKSYYLQRKRWAKGNYEVVIANFKHLFGRGNWRVKWEVFYYTCTFFWFNAAIVLSDILFFSNLIALIIGLFKPGVQVPFAFDANNIYMAQLLLFNWFLMILLYLLQISISQATQYGQATVKQIWIALLAYFTYTQLFIIVSISSVASVMMDKILHREGTKWVKTKRFAG","1366521","","glycosyl transferase","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins and to glycosyltransferase: residues 2-385 are 33% similar to conserved hypothetical in Listeria innocua (gi16799608).Residues 2-365 are 27% similar to Lactococcus lactis (gi15672662). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1548 (2e-10).","

InterPro
IPR001173
Domain

Glycosyl transferase, family 2
PF00535	$\"[3-179]T$	Glycos_transf_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[1-219]T$	G3DSA:3.90.550.10
PTHR22916	$\"[8-333]T$	PTHR22916
SSF53448	$\"[1-203]T$	SSF53448

","BeTs to 7 clades of COG1215COG name: Glycosyltransferases, probably involved in cell wall biogenesisFunctional Class: MThe phylogenetic pattern of COG1215 is A-t--Q-cEb-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 74-130 are 45% similar to a (SYNTHASE TRANSFERASE TRANSMEMBRANE GLYCOSYLTRANSFERASE) protein domain (PD007872) which is seen in P96587_BACSU.Residues 155-284 are 26% similar to a (TRANSFERASE COMPLETE PROTEOME GENES) protein domain (PD276481) which is seen in Q52257_SALBO.Residues 2-45 are 56% similar to a (TRANSFERASE COMPLETE PROTEOME GLYCOSYLTRANSFERASE) protein domain (PD000196) which is seen in P96587_BACSU.Residues 165-233 are 40% similar to a (TRANSFERASE CELLULOSE SYNTHASE PROTEOME) protein domain (PD119213) which is seen in P96587_BACSU.Residues 2-110 are 32% similar to a (CELLULOSE SYNTHASE CATALYTIC SUBUNIT) protein domain (PD008572) which is seen in YHJO_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 3 15:19:08 2003","Thu Mar 8 14:12:40 2007","Thu Mar 8 14:12:40 2007","Mon Mar 11 11:01:12 2002","","Mon Mar 11 11:01:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1308 is paralogously related (blast p-value < 1e-3) to SMu0758, also a predicted conserved hypothetical protein; possible glycosyltransferase.","Fri Jan 3 15:19:08 2003","Thu Mar 8 14:12:40 2007","pdb1QGQA Chain A, Udp-Manganese Complex Of Spsa From Bacillus... 199 5e-052","SMU.1434c","","Residues 3 to 179 (E-value = 1.4e-14) place SMu1308 in the Glycos_transf_2 family which is described as Glycosyl transferase (PF00535)","Mon Mar 11 11:01:12 2002","24379836","","","","","","1","","","SMU.1434c","" "SMu1309","1367949","1367788","162","ATGAACTTAACAAACTTATTTTTTAACATTGGTCTTGGCATCAGTCTCTTTTTTGCGGCCTGTTTTGTCACCTTGTTTATTAGTTATTTAGTTATTTTAGAAAGAGTTAATAAAAATTTTAAGGCGGTGGATGATGATGAGTCAAATTCTAATGATTATTAG","4.10","-3.07","6040","MNLTNLFFNIGLGISLFFAACFVTLFISYLVILERVNKNFKAVDDDESNSNDY","1367803","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.SMu1309 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-33]?$	signal-peptide
tmhmm	$\"[10-32]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[2-22]?$ $\"[28-50]?$ $\"[60-80]?$	transmembrane_regions

InterPro
IPR003331
Family

UDP-N-acetylglucosamine 2-epimerase
PTHR18964:SF2	$\"[29-374]T$	Epimerase_2
PF02350	$\"[24-366]T$	Epimerase_2
TIGR00236	$\"[4-369]T$	wecB

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2000	$\"[1-228]T$	G3DSA:3.40.50.2000
PTHR18964	$\"[29-374]T$	PTHR18964
SSF53756	$\"[2-380]T$	SSF53756

","BeTs to 8 clades of COG0381COG name: UDP-N-acetylglucosamine 2-epimeraseFunctional Class: MThe phylogenetic pattern of COG0381 is -mtk--Vceb----------xNumber of proteins in this genome belonging to this COG is 1","***** IPB003331 (UDP-N-acetylglucosamine 2-epimerase) with a combined E-value of 4.4e-145. IPB003331A 5-23 IPB003331B 58-95 IPB003331C 100-136 IPB003331D 163-181 IPB003331E 200-215 IPB003331F 234-249 IPB003331G 279-322 IPB003331H 350-363","Residues 58-365 are 61% similar to a (2-EPIMERASE UDP-N-ACETYLGLUCOSAMINE) protein domain (PD004092) which is seen in YVYH_BACSU.Residues 5-50 are 71% similar to a (2-EPIMERASE UDP-N-ACETYLGLUCOSAMINE) protein domain (PD003764) which is seen in Q9RMD6_ACILW.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 11:14:44 2002","Mon Mar 11 11:12:57 2002","Tue Mar 27 13:48:36 2007","Mon Mar 11 11:12:57 2002","Mon Mar 11 11:12:57 2002","Mon Mar 11 11:12:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1311 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 11:14:44 2002","Tue Mar 27 13:48:36 2007","pdb1F6DA Chain A, The Structure Of Udp-N-Acetylglucosamine 2-... 352 4e-098","SMU.1437c","","Residues 24 to 366 (E-value = 2.2e-171) place SMu1311 in the Epimerase_2 family which is described as UDP-N-acetylglucosamine 2-epimerase (PF02350)","Mon Mar 11 11:12:57 2002","","","","Kiser KB, Bhasin N, Deng L, Lee JC.Staphylococcus aureus cap5P encodes a UDP-N-acetylglucosamine 2-epimerase with functional redundancy.J Bacteriol. 1999 Aug;181(16):4818-24.PMID: 10438750 ","","Mon Mar 11 11:14:44 2002","1","","","SMU.1437c","" "SMu1312","1370932","1370234","699","ATGAAGACTTTCATTAAAATTTTGTTTTTTATTCCTAGACTAATATGGAATATTATTTGGAGCATCATTAAAACTCTTATTATTCTTGCTGCTATTATTTTTGCTTTTCTTTATTTTACAAATAATCATAAAACAGACTTGGAATCAACGATCTCCGAACAATGGAATAAGATAACGACTTTTTTTAGTAATGACTTTAGTTTGCCGGATACGATGTCTAAATTATCAACAGATAATTATAAACATGAAGCAGGGAGTCGTTGGAGTCAAAATAGTGCTAGTGTTTATATAGCTTCTACTGATAAAACTATTGTTAAGGCTTACCAAACTGCTCTGGCTAATTGGAATGCAACAGGAAGTTTCACTTTTAATATCATTTCGGATAAAGCATCAGCAGATATTACAGCAAAGGATTATTCTGATGTAAATTCGCAAGCCGCTGGTTTAGCTGAAACAGAAACGAATGCAGTGACCAATCGCATGAGTCATGTTGATGTTAAGCTTAATCGCTACTATCTTTTAGATGCAAGTTACGGTTATAGTTTTGATAGGATAGTCCACACAGCAGAGCATGAGTTAGGGCATGCTATAGGACTTGATCATGATGATAAAGAAACTTCGGTAATGGCCTCATCAGGTTCCTACAATGGTATTCAAACAGTTGATATAACTGCTGTTAAGAAGCTTTACGCTAATTAA","6.40","-2.32","26028","MKTFIKILFFIPRLIWNIIWSIIKTLIILAAIIFAFLYFTNNHKTDLESTISEQWNKITTFFSNDFSLPDTMSKLSTDNYKHEAGSRWSQNSASVYIASTDKTIVKAYQTALANWNATGSFTFNIISDKASADITAKDYSDVNSQAAGLAETETNAVTNRMSHVDVKLNRYYLLDASYGYSFDRIVHTAEHELGHAIGLDHDDKETSVMASSGSYNGIQTVDITAVKKLYAN","1370249","For other 'prt' genes see SMu0590 (prtM).","conserved hypothetical protein; possible protease","Membrane, Extracellular","Limited matches in gapped BLAST to hypotheticals and protease: residues 72-230 are 48% similar to a hypothetical from S.pneumoniae (gi15902586) and residues 94-226 are 29% similar to a protease B from Myxococcus xanthu (gi2780185). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1184 (8e-50).","

InterPro
IPR001818
Domain

Peptidase M10A and M12B, matrixin and adamalysin
PR00138	$\"[108-123]T$ $\"[188-213]T$	MATRIXIN
PF00413	$\"[87-231]T$	Peptidase_M10

InterPro
IPR006025
Binding_site

Peptidase M, neutral zinc metallopeptidases, zinc-binding site
PS00142	$\"[188-197]?$	ZINC_PROTEASE

InterPro
IPR006026
Domain

Peptidase, metallopeptidases
SM00235	$\"[84-232]T$	ZnMc

noIPR
unintegrated

unintegrated
G3DSA:3.40.390.10	$\"[85-231]T$	G3DSA:3.40.390.10
PTHR10201	$\"[46-56]T$ $\"[178-231]T$	PTHR10201
PTHR10201:SF12	$\"[46-56]T$ $\"[178-231]T$	PTHR10201:SF12
SSF55486	$\"[87-230]T$	SSF55486

","BeTs to 3 clades of COG1913COG name: Predicted Zn-dependent proteasesFunctional Class: RThe phylogenetic pattern of COG1913 is am-K-q---------------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 31 16:10:14 2006","Mon Jul 31 16:10:14 2006","Mon Jul 31 16:10:14 2006","Mon Mar 11 11:18:53 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1312 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 11:19:58 2002","","No significant hits to the NCBI PDB database.","SMU.1438c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 11:18:53 2002","24379840","","","Quillet,L., Bensmail,L., Barray,S. and Guespin-Michel,J.Cloning and sequencing of two genes, prtA and prtB, from Myxococcus xanthus, encoding PrtA and PrtB proteases, both of which are required for the protease activityGene 198 (1-2), 135-140 (1997)PubMed: 9370274","","Mon Mar 11 11:19:58 2002","1","","","SMU.1438c","686" "SMu1313","1372084","1371533","552","ATGAAAGTGAGGATTCGATTTGTGAAAAAGAAATTAAGTATTGTGTTAGGGCTGATTATTGTAGCTGTAACATTTTTTACCTTAACTAATCAAAAAACGGTAAGTGCTAATTCATCTCGTGTAGAAACAGTGTCCTACCAACTTCTTAAAGAAGGTGTAGCTGATGTTAGATTGACTTACTATCATAATAAAGGCAATGATAAGGTACTTAAACAAACGGCGGAATCAAAAATCCTTTATTCAGCACTCAAGGTGACAGATGCTCAAGCAGCAAAAGAGAAGGTTGGCTCTCAATCAGAGAAATATCAAGGTATTACAGGTGTTCAGGAAAGTGTTGCTTACAAAGATGTCTATTTGATAGAAAAAGTAAGTGTAGATTATACCAAAGCTAATCTTAATGAATTAGCGAAAAAGCTTCCAGAAGTAAACATTAATACTCCTTCAGGTAAAAGAGCAACTTATATTAGCTTAAAGCAAAGTGAAAGATTTCTCAAAAAACAGGGTTACAGCAAAGTTAAAAATGGTCATTTTAAAGAATTGAAAGTGAATTAA","10.70","17.47","20567","MKVRIRFVKKKLSIVLGLIIVAVTFFTLTNQKTVSANSSRVETVSYQLLKEGVADVRLTYYHNKGNDKVLKQTAESKILYSALKVTDAQAAKEKVGSQSEKYQGITGVQESVAYKDVYLIEKVSVDYTKANLNELAKKLPEVNINTPSGKRATYISLKQSERFLKKQGYSKVKNGHFKELKVN","1371548","","conserved hypothetical protein","Extracellular, Membrane","Limited matches in gapped BLAST to hypothetical lipoprotein: residues 10-173 are 37% similar to Listeria innocua (gi|16799316|) and residues 10-172 are 36% similar to Listeria monocytogenes(gi|16802253|). SMu1313 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR009736
Family

Protein of unknown function DUF1307
PF06998	$\"[42-171]T$	DUF1307

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 10-172 are 36% similar to a (LIPOPROTEIN MEMBRANE PRECURSOR SIGNAL) protein domain (PD034059) which is seen in YORZ_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 11:23:59 2002","Mon Mar 11 11:23:59 2002","Mon Mar 11 11:23:59 2002","Mon Mar 11 11:23:59 2002","","Mon Mar 11 11:23:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1313 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 11:23:59 2002","","No significant hits to the NCBI PDB database.","SMU.1442c","","Residues 42 to 171 (E-value = 1.8e-78) place SMu1313 in the DUF1307 family which is described as Protein of unknown function (DUF1307) (PF06998)","Mon Mar 11 11:23:59 2002","24379841","","","","","","1","","","SMU.1442c","" "SMu1314","1372946","1372155","792","ATGGCTTTTTTTCAGATAGAATACAATTCCAAAACTTTAGGGATGGAACGCCATGTCAATGTTATTTATCCTGATGCTTCAGAGATTAAGGAAGATTATATAAATGATACCGATATTCCTGTTCTTTATCTTTTGCACGGTATGGGCGGCAATGAAAATTCATGGCAAAAGCGGACAGCTATTGAACGTCTCGTTAGAAAGACAAATCTTATCGTTATTATGCCATCAACTGATTTAGCATGGTATACCAATACAGCTTATGGCTTGGATTATTATGATATGATTGCCAAAGAACTACCTCAAATTCTGCAGCGTTTCTTTCCAAATATGACAAAAAAACGTGAGAAAACTTTTATTGCGGGACTTTCCATGGGAGGTTACGGAGCTTATAAGATTGCTCTTTCAACAGATAAGTTTTCTCACGCAGCTTCTTTTTCAGGTGCACTTGGACTTGGAATTGATGGTCAAGACCTAGGAGAAACGACAGGAGCATCTCAAAACTATTGGGAAGGCATCTTTGGAAATTTACAAGGAAAACAGTTACAGGAACATTTTCTGACAACACTAGCAGAAAAGTCTGATAAAAAAACCAAGTTCTACGCTTGGTGCGGTTATGAAGATATTCTTTATCAGGCTAATGAAACAGCTGTGAAAAAATTAAGAAAGATAGGGCTTAATATTGACTATCGTAACGACCATGGCAGACATGAGTGGTACTATTGGGAAAAACAGTTGAATTTTCTTTTAGAATGGCTTCCTATTGACTATCAAAAAGAAGAACGGTTGTCCTAA","6.30","-2.59","30487","MAFFQIEYNSKTLGMERHVNVIYPDASEIKEDYINDTDIPVLYLLHGMGGNENSWQKRTAIERLVRKTNLIVIMPSTDLAWYTNTAYGLDYYDMIAKELPQILQRFFPNMTKKREKTFIAGLSMGGYGAYKIALSTDKFSHAASFSGALGLGIDGQDLGETTGASQNYWEGIFGNLQGKQLQEHFLTTLAEKSDKKTKFYAWCGYEDILYQANETAVKKLRKIGLNIDYRNDHGRHEWYYWEKQLNFLLEWLPIDYQKEERLS","1372170","","tributyrin esterase","Cytoplasm, Extracellular","Several matches in gapped BLAST to tributyrin esterase: residues 1-263 are 64% similar to the enzyme in S.pyogenes (gi15675022) and are 58% similar to the protein from S.pneumoniae (gi15900522).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1185 (1e-106).","

InterPro
IPR000801
Family

Putative esterase
PF00756	$\"[2-252]T$	Esterase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[5-263]T$	G3DSA:3.40.50.1820
PTHR10907	$\"[6-183]T$	PTHR10907
PTHR10907:SF3	$\"[6-183]T$	PTHR10907:SF3
SSF53474	$\"[1-261]T$	SSF53474

","BeTs to 3 clades of COG0627COG name: Predicted esteraseFunctional Class: RThe phylogenetic pattern of COG0627 is ----y--cE--h---------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 1-263 are 54% similar to a (ESTERASE PROTEOME COMPLETE LIPASE) protein domain (PD123655) which is seen in Q9L9X0_LACLA.Residues 29-141 are 30% similar to a (GLYCOSIDASE XYLAN DEGRADATION HYDROLASE) protein domain (PD017485) which is seen in Q9EZ25_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 11:37:32 2002","Mon Mar 11 11:35:10 2002","Wed Aug 30 15:50:58 2006","Mon Mar 11 11:35:10 2002","","Fri Dec 14 15:05:26 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1314 is paralogously related (blast p-value < 1e-3) to SMu0106, a predicted esterase.","Mon Mar 11 11:37:32 2002","","No significant hits to the NCBI PDB database.","SMU.1443c","","Residues 2 to 252 (E-value = 6.8e-06) place SMu1314 in the Esterase family which is described as Putative esterase (PF00756)","Fri Dec 14 15:05:26 2001","24379842","","","Fernandez,L.,Beerthuyzen,M.M., Brown,J.,Siezen,R.J., Coolbear,T.,Holland,R. and Kuipers,O.P.Cloning, Characterization, Controlled Overexpression, andInactivation of the Major Tributyrin Esterase Gene of LactococcuslactisAppl. Environ. Microbiol. 66 (4), 1360-1368 (2000)PUBMED 10742212","","Mon Mar 11 11:37:32 2002","1","","","SMU.1443c","572" "SMu1315","1375098","1373434","1665","ATGAGTGACATTAAAATTATTGCCCTAGGCGGAGTTCGTGAAAATGGTAAGAACTTCTATGTGGTAGAAGTCAACGACGCCATTTTCATTCTTGATGCTGGGCTTAAGTATCCAGAAAATGAACAGTTAGGTGTTGATGTTGTTATTCCTAATCTGGATTATCTGATTGAAAATAAAAAGCGTGTACAGGGAATTTTTTTAACCCATGGACATGCTGATGCTATTGGTGCTTTGCCTTATTTGTTGAGTGATGTCAAAGCTCCGGTATTTGGTTCTGAGTTAACGATTGAACTAGCTAAGTTGGTCGTTAAAAACAACGATGCAACTAAGAAATTCCATAATTTCCATGTGGTTGATGCTCAAACTGAAATTGAATTTGACGATGCTATTATTTCTTTTTTCAAAACTACCCATTCTATACCAGAAAGTTTAGGAATTGTAGTTGGCACTAAAGAAGGCAATATTGTTTATACAGGTGATTTTAAGTTTGACCAAGCAGCCAGCAAGCTTTATCAGACTGACTTAGCTCGCATTGCTGAAATTGGACGTGAAGGTGTTCTGGCACTTTTATCAGATTCTGCTAATGCTGATAGCACTGTTCAAATTGCCAGTGAAGCTGAAGTAGGTATTGAAATGGAGCAAGTCATTTCCAATTGGGAAGGACGTATTATCGTCGCTGCAGTAGCCTCTAATCTTGTTCGTATCCAACAAGTCTTTGATTCGGCTGCTAACAATGGCCGCCGTGTTGTGCTGACAGGTTATGATGTTGAAAATATTGTTCGAACAGCTATCCGTCTTAAAAAGCTTTCTCTGGTTGATGAAAAACTTATTGTCAAACCAAAAGATATGCATAAATTTGAAGATCATGAACTAATTATTTTAGAAACTGGTCGGATGAGCGAGCCACTCAATGGTTTAAGAAAAATGGCTATTGGCCGTCATCGTTATGTTGAAATTAAAGATGGTGATTTGGTCTATATTGTAACAACACCTACTGTTTCTAAAGAAGCCGTTGTTGCGCGTGTTGAGAATATGATTTATAAGGCTGGCGGTGATGTGAGACTCATTACTCAGGACTTACGTGTATCTGGCCATGCTAATGGTCGTGATCTTCAACTGATGATTAATCTGCTTAAGCCCAAATATCTCTTCCCTATACAAGGAGAATATCGTGAATTAGCTGCCCATGCTGATTTGGCTCTTGAAATAGGCATGTTTCCGGAAAATATTTATATTATGAAACATGGTGACATTATGGTTTATGATAAAGAGGATGGTTTCTTACATGAAGGCGGTATCCCGGCTGGAGATGTCATGATTGATGGCAATGCTATTGGTGATGTTGGCAATATTGTTTTACGAGACCGCAAGGTGCTTTCTGAAGATGGTATCTTTATCATTGCCTTAACTGTCAATAAAAAAGAAAAGAAAATCATTTCAAGAGCTAAAATCAATACACGTGGTTTTGTTTATGTCAGAAAAAGCCGTGATATTTTACGCGAAAGTGCAGATATTGTCAATAAGGCTGTTGAAAATTATTTGCAACAAGATACGTTTGATTGGGGAGAATTGAAATCTATTGTTCGTGATGAAATTGGTAAATTTCTTTTTGAACAAACTAAGCGTCGTCCAGCTATTTTACCAGTAGTTATGGAAGTTAGATAA","5.80","-9.05","61819","MSDIKIIALGGVRENGKNFYVVEVNDAIFILDAGLKYPENEQLGVDVVIPNLDYLIENKKRVQGIFLTHGHADAIGALPYLLSDVKAPVFGSELTIELAKLVVKNNDATKKFHNFHVVDAQTEIEFDDAIISFFKTTHSIPESLGIVVGTKEGNIVYTGDFKFDQAASKLYQTDLARIAEIGREGVLALLSDSANADSTVQIASEAEVGIEMEQVISNWEGRIIVAAVASNLVRIQQVFDSAANNGRRVVLTGYDVENIVRTAIRLKKLSLVDEKLIVKPKDMHKFEDHELIILETGRMSEPLNGLRKMAIGRHRYVEIKDGDLVYIVTTPTVSKEAVVARVENMIYKAGGDVRLITQDLRVSGHANGRDLQLMINLLKPKYLFPIQGEYRELAAHADLALEIGMFPENIYIMKHGDIMVYDKEDGFLHEGGIPAGDVMIDGNAIGDVGNIVLRDRKVLSEDGIFIIALTVNKKEKKIISRAKINTRGFVYVRKSRDILRESADIVNKAVENYLQQDTFDWGELKSIVRDEIGKFLFEQTKRRPAILPVVMEVR","1373449","","metallo-beta-lactamase superfamily proteinhetical protein","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-554 are 78% similar to gi15675021 from S.pyogenes and are 59% similar to gi15673600 from Lactococcus lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1186 (0.0).","

InterPro
IPR001279
Domain

Beta-lactamase-like
PF00753	$\"[16-164]T$	Lactamase_B

InterPro
IPR011108
Domain

RNA-metabolising metallo-beta-lactamase
PF07521	$\"[354-391]T$	RMMBL

noIPR
unintegrated

unintegrated
G3DSA:3.60.15.10	$\"[4-172]T$	G3DSA:3.60.15.10
SSF56281	$\"[6-211]T$	SSF56281

","BeTs to 9 clades of COG0595COG name: Predicted metal-dependent hydrolase 3Functional Class: RThe phylogenetic pattern of COG0595 is -mTK--vc-Br-ujGP----xNumber of proteins in this genome belonging to this COG is 2","***** IPB001587 (Uncharacterized protein family UPF0036) with a combined E-value of 3.6e-123. IPB001587A 5-44 IPB001587B 45-93 IPB001587C 131-165 IPB001587D 218-269 IPB001587E 278-329 IPB001587F 360-404","Residues 408-497 are 53% similar to a (PROTEOME COMPLETE YCIH YQGA) protein domain (PD414201) which is seen in Q9CF63_LACLA.Residues 18-94 are 70% similar to a (COMPLETE PROTEOME HYDROLASE FACTOR POLYADENYLATION) protein domain (PD000482) which is seen in Q9CF63_LACLA.Residues 415-497 are 44% similar to a (PROTEOME COMPLETE ML1512 BH2662) protein domain (PD017630) which is seen in Q9K9I5_BACHD.Residues 498-552 are 56% similar to a (PROTEOME COMPLETE BH2662 ADEC-PDHA) protein domain (PD039891) which is seen in Q9CF63_LACLA.Residues 95-396 are 58% similar to a (COMPLETE PROTEOME MG139 CLONE:MLE2) protein domain (PD006373) which is seen in Q9CF63_LACLA.Residues 436-547 are 22% similar to a (PROTEOME COMPLETE MG423 TRANSMEMBRANE) protein domain (PD125690) which is seen in Q9X495_MYCFE.Residues 1-391 are 25% similar to a (MG423 TRANSMEMBRANE COMPLETE) protein domain (PD043468) which is seen in Q9PPY1_UREPA.Residues 433-546 are 28% similar to a (MG139 PROTEOME COMPLETE UU570) protein domain (PD039887) which is seen in Q9PPR9_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 13:06:27 2002","Thu Aug 10 08:45:02 2006","Thu Aug 10 08:45:02 2006","Mon Mar 11 13:06:02 2002","Mon Mar 11 13:06:02 2002","Mon Mar 11 13:06:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1315 is paralogously related (blast p-value < 1e-3) to SMu0333, also a predicted conserved hypothetical protein.","Mon Mar 11 13:06:27 2002","","No significant hits to the NCBI PDB database.","SMU.1444c","","Residues 16 to 205 (E-value = 6.2e-22) place SMu1315 in the Lactamase_B family which is described as Metallo-beta-lactamase superfamily (PF00753)","Mon Mar 11 13:06:02 2002","24379843","","","","","","1","","","SMU.1444c","131" "SMu1316","1376103","1375345","759","ATGACTAAAATTGTTGAATTAAAGAATGCTACGGTTCAAGTTAACAATGGCTTTGATGATTATAAGACAATTCTTGATGATGTCAGTTTAGATATATACGAACGTGATTTTTTGACCATTCTTGGTGGAAATGGAGCAGGGAAATCAACTCTCTTTAATGTCCTTGCTGGCACACTGTCTTTGACTGACGGCAGCATTTCTATTATGGGAGAAGATGTCACCGCCTATCCTGCTGAAAAGCGAGCAAAATATCTATCGCGTGTCTTTCAGGATCCTAAAATGGGGACTGCACCAAGAATGACAGTTGCGGAAAATCTCTTAATTGCCAAATACCGTGGTGAAAAACGTGGACTTGTCTCGCGCCGCATTAGTGCTTATAAAGAAGAGTTTCAAGCAGTAATTGATAAAATTGGCAATGGCCTTGAAAAGCATCTAGAGACCCCAACAGGCTTGCTATCAGGTGGGCAAAGACAAGCGCTCAGTTTGCTTATGGCAACCATCAAACGTCCAGAGCTTTTGTTACTTGATGAGCATACAGCGGCTCTGGATCCTAAAACCAGTGTTGCTCTAATGACACTGACAGAAGAATTCGTGAAACGTGATCATCTAACAGCCCTCATGATTACTCATCGTATGGAAGATGCTCTTAAATATGGCAATCGCCTCTTGGTAATGGAAGACGGTCGTATTATCCAAGATTTATCGGCCGAAGAAAAAGCAAAGATGAACATTTCAGACTATTACGGACTGTTTGAATAA","5.80","-3.02","28037","MTKIVELKNATVQVNNGFDDYKTILDDVSLDIYERDFLTILGGNGAGKSTLFNVLAGTLSLTDGSISIMGEDVTAYPAEKRAKYLSRVFQDPKMGTAPRMTVAENLLIAKYRGEKRGLVSRRISAYKEEFQAVIDKIGNGLEKHLETPTGLLSGGQRQALSLLMATIKRPELLLLDEHTAALDPKTSVALMTLTEEFVKRDHLTALMITHRMEDALKYGNRLLVMEDGRIIQDLSAEEKAKMNISDYYGLFE","1375360","For other component see SMu1317 (MSD1).For other 'liv' genes see SMu1517 (livF); SMu1518 (livG); SMu1519 (livM); SMu1520 (livH) and SMu1521 (livK).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","This sequence was previously published in GenBank as gi1661179, a predicted high affinity branched chain amino acidtransport protein. Additional similarities are to ABC transporters. Residues 1-252 are 80% similar to gi15900940from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1187 (1e-106).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[152-193]T$	ABC_transporter
PF00005	$\"[37-228]T$	ABC_tran
PS00211	$\"[152-166]?$	ABC_TRANSPORTER_1
PS50893	$\"[5-252]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[34-229]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-238]T$	G3DSA:3.40.50.300
PTHR19222	$\"[5-238]T$	PTHR19222
SSF52540	$\"[4-238]T$	SSF52540

","BeTs to 6 clades of COG1130COG name: ABC-type sugar transport system, ATPase componentFunctional Class: GThe phylogenetic pattern of COG1130 is -mtK--VCEBRh--GP-L---Number of proteins in this genome belonging to this COG is 4","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.5e-27. IPB001140A 24-70 IPB001140B 149-187 IPB001140C 204-233","Residues 97-229 are 28% similar to a (ATP-BINDING PROTEOME RIBOSE/GALACTOSE) protein domain (PD215671) which is seen in O83322_TREPA.Residues 24-230 are 24% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 80-151 are 45% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD336916) which is seen in Q9KJT5_ENTGA.Residues 140-215 are 36% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in Q9CCF9_MYCLE.Residues 25-74 are 52% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9KWE8_AGRRH.Residues 152-193 are 73% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9KJT5_ENTGA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 13:24:22 2006","Wed Sep 13 13:24:22 2006","Wed Sep 13 13:24:22 2006","Mon Mar 11 13:11:09 2002","Mon Mar 11 13:11:09 2002","Mon Mar 11 13:11:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1316 is paralogously related (blast p-value < 1e-3) to SMu0884, SMu1003, SMu1210, SMu1757, SMu0986, SMu0916, SMu1023, SMu0971, SMu1288, SMu0517, SMu1518, SMu1920, SMu1950, SMu1068, SMu1064, SMu0786, SMu0235, SMu1380, SMu1428, SMu1751, SMu1762, SMu1517, SMu0805, SMu1246, SMu1231, SMu0731, SMu0218, SMu1649, SMu1410, SMu0825, SMu0824, SMu1065, SMu0849, SMu1079, SMu1949, SMu0390, SMu0335, SMu0594, SMu0837, SMu0476, SMu0234, SMu1001, SMu0987, SMu0475, SMu0258, SMu1811, SMu0596, SMu1710, SMu1036, SMu0907, SMu0823, SMu0944, SMu1306, SMu1724, SMu0836, SMu0216, SMu0418, SMu0374, SMu0976, SMu1037, SMu0752, SMu1545, SMu0224, SMu0024, SMu0950, SMu1093, SMu0729, SMu0164, SMu1959, SMu1050, SMu1202, and SMu0666, all with ATP binding capabilities.","Wed Apr 10 14:45:01 2002","Wed Sep 13 13:24:22 2006","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 85 1e-017pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 69 5e-013","SMU.1445c","","Residues 35 to 228 (E-value = 2.3e-45) place SMu1316 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Mar 11 13:11:09 2002","24379844","","","","Tue Oct 29 14:20:07 2002","","1","","","SMU.1445c","389" "SMu1317","1376969","1376100","870","ATGTTACTTTCAACCATTTCTCAAGGTTTTCTTTGGTCCATTTTAGGTTTAGGTATTTTTATGACCTTTCGCATTTTAAATTTTCCTGATATGACGACGGAAGGTTCCTTTCCTTTAGGAGGAGCAGTGGCTGTGAGTTTGATCACACAGGGAATGAATCCCTTATTAGCAACTATTATTGCAAGTTTGTCAGGCTGTCTGGCAGGACTAGCAGCAGGACTTCTTTATACTAAAGGGAAAATTCCCACGCTTTTATCAGGAATTCTGGTTATGACCTCTTGTCATTCTGTTATGTTGATGATTATGGGACGGGCAAATTTAGGTCTTTTAGATGCTAAAAAATTACAGGATCTCTTACCCTTTTCAGGAGAGATTAATCTCCTTAGTTTAGGTCTTATTTTTGTTTTTCTTGTCGTTAGCGCGATGATTTTCTTTCTTAATACACGTCTGGGACAAGCCTACATTGCAACAGGTGATAATCATGATATGGCCAAGAGTTTTGGCATACATACAGATAAGATGGAATTAATGGGGCTCATTTTATCTAACGGTATTATTGCCTTATCCGGTGCTCTGATTAGCCAGCAAGATGGTTATGCAGATGTTTCAAAAGGAATTGGTGTCATTGTTATTGGGTTGGCTAGTATTATTATTGGTGAAGTTCTCTTTTCGACGAGTCTAACGTTATTGGAGCGTTTATTAGCTATTGTCGTTGGTTCTGTTCTTTATCAATTCTTGATTTTAGCTGTTATTTCAATGGGCTTTAAGACCAACTATCTCAAACTCTTCAGTGCTTTAGTCTTGGCTATCTGTCTTATGATTCCAGAGCTGAAAAAGAAATTCTTCAAAGGAGTGAAGTTATCACGATGA","9.70","5.57","30818","MLLSTISQGFLWSILGLGIFMTFRILNFPDMTTEGSFPLGGAVAVSLITQGMNPLLATIIASLSGCLAGLAAGLLYTKGKIPTLLSGILVMTSCHSVMLMIMGRANLGLLDAKKLQDLLPFSGEINLLSLGLIFVFLVVSAMIFFLNTRLGQAYIATGDNHDMAKSFGIHTDKMELMGLILSNGIIALSGALISQQDGYADVSKGIGVIVIGLASIIIGEVLFSTSLTLLERLLAIVVGSVLYQFLILAVISMGFKTNYLKLFSALVLAICLMIPELKKKFFKGVKLSR","1376115","For other component see SMu1316 (NBD1).","ABC transporter, permease","Membrane, Cytoplasm","Similarities are to ABC transporters, many of which are concerned with permease. Residues 1-289 are 69% similar to gi15903020 from S.pneumoniae.Residues 2-280 are 37% similar to gi15599032 from Pseudomonas aeruginosa.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1188 (1e-118).","

InterPro
IPR001851
Family

Bacterial inner-membrane translocator
PF02653	$\"[1-272]T$	BPD_transp_2

","BeTs to 3 clades of COG1172COG name: Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease componentsFunctional Class: GThe phylogenetic pattern of COG1172 is ------V-Eb-H-----l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 9-247 are 36% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000838) which is seen in Q9KT03_VIBCH.Residues 2-119 are 38% similar to a (PROTEOME COMPLETE OF ABC) protein domain (PD338829) which is seen in Q9HXG7_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 10:24:37 2002","Wed Sep 13 13:29:26 2006","Wed Sep 13 13:29:26 2006","Mon Mar 11 13:16:16 2002","","Mon Mar 11 13:16:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1317 is paralogously related (blast p-value < 1e-3) to SMu1520, a predicted branched chain amino acid ABC transporter, permease protein and SMu1021, a predicted sugar ABC transporter (permease protein). ","Mon Mar 11 13:16:16 2002","","No significant hits to the NCBI PDB database.","SMU.1446c","","Residues 1 to 272 (E-value = 1.3e-17) place SMu1317 in the BPD_transp_2 family which is described as Branched-chain amino acid transport system / permease component (PF02653)","Mon Mar 11 13:16:16 2002","24379845","","","","","","1","","","SMU.1446c","390" "SMu1318","1378081","1377080","1002","ATGAAAAATAAACGTTTATTGGGCGTTTTATTGGCTCTAGCTGTACTTGTTATTGGTATTTTAGTTTACCAATCCGTTGACAAACAAAATAGGAAGAATTCACAATCGGAAACTTTTAAAGTTGGTGTGCTCCAATATGTCAGTCACAATGCGTTAGATGAGATTTATCGTGGTATTAAGGCTGGTCTTAAAGAAGAAGGTTATTCTGGCAAAAAAATCAAAATTGATTTTATGAATGCTGAAGGTGATCAAAGCAAAGTACAAACCATGAGTCAGACCCTAGTCAATCATAAAAATGATGTTCTCGTTGGTATTGCTACACCAGCAGCACAAGGATTGGCCAGTGCAACCAAAAAGACACCAATTATTATGGGGGCTGTGACTGATCCCGTTGGTGCCAAATTGGTTAAAGATTTGAAAAAACCAAATGGAAATGTAACGGGTGTTTCAGACAAGACACCAATCAGTGATCAAGTTAGTTTAATCAAAAAATTAACGCCAGATGTCAAAACAGTTGGTATTCTCTATTCTAGCAGTGAAGATAATTCAAAATCCCAAGTGGAGGAATTTAAAAAAATTGCTGAGAAAAAAGGCTACAAGGTTCTGGAATATTCTGTTCCTTCAACCAATGAGATTGCGACTACAATGAATGTGATGCTGGATAAGACAGATGCTGTCTGGATTCCTTTGGACAATACAATTGCCAGTGCCTTTCCAACAGTGGTATCAGCGGCTAAAACAGCTAAAAAACCTATCTATCCAAGTGTTGATACCATGGTAACAGAAGGTGGACTTGCTTCGGTTGTTGTCGATCAGTATAAATTGGGTGTTGCTACTGGTAAAATGGCTGTTAAAGTGTTTGAAGGTAAAAAAGTTTCACAACTTCCTGTTGATATTTTTGATAAGGGAACCCCAGTTGTGAATAAAAAAGTTGCGAAAGAGTTAGGCATTGATATCCCATCTGATATTTTGAAAAAAGCAAAACAGCAAAAGAATCAATGA","10.30","14.49","35893","MKNKRLLGVLLALAVLVIGILVYQSVDKQNRKNSQSETFKVGVLQYVSHNALDEIYRGIKAGLKEEGYSGKKIKIDFMNAEGDQSKVQTMSQTLVNHKNDVLVGIATPAAQGLASATKKTPIIMGAVTDPVGAKLVKDLKKPNGNVTGVSDKTPISDQVSLIKKLTPDVKTVGILYSSSEDNSKSQVEEFKKIAEKKGYKVLEYSVPSTNEIATTMNVMLDKTDAVWIPLDNTIASAFPTVVSAAKTAKKPIYPSVDTMVTEGGLASVVVDQYKLGVATGKMAVKVFEGKKVSQLPVDIFDKGTPVVNKKVAKELGIDIPSDILKKAKQQKNQ","1377095","","ABC transporter, substrate-binding protein","Membrane, Periplasm, Extracellular","Significant hits in gapped BLAST to conserved hypothetical protein. Residues 1-329 are 61% similar to gi15900938 in S.pneumoniae.Residues 1-332 are 50% similar to gi15675017 in S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1189 (1e-100).","

InterPro
IPR007487
Family

ABC transporter substrate binding protein
PF04392	$\"[40-331]T$	ABC_sub_bind

noIPR
unintegrated

unintegrated
SSF53822	$\"[37-262]T$	SSF53822

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 36-308 are 39% similar to a (PROTEOME COMPLETE VC1101 PA3836) protein domain (PD340191) which is seen in Q9KT04_VIBCH.Residues 40-329 are 22% similar to a (PROTEOME COMPLETE) protein domain (PD131616) which is seen in O67196_AQUAE.Residues 74-333 are 25% similar to a (PROTEOME COMPLETE CT391 TC0670) protein domain (PD191513) which is seen in Q9Z855_CHLPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 13:41:26 2006","Wed Sep 13 13:41:26 2006","Wed Sep 13 13:41:26 2006","Mon Mar 11 13:21:18 2002","","Mon Mar 11 13:21:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1318 is paralogously related (blast p-value < 1e-3) to SMu1521, a predicted ABC transporter, periplasmic branched chain amino acid-binding protein.","Wed Sep 13 13:41:26 2006","","No significant hits to the NCBI PDB database.","SMU.1447c","","Residues 40 to 331 (E-value = 7.6e-139) place SMu1318 in the DUF534 family which is described as Protein of unknown function (DUF534) (PF04392)","Mon Mar 11 13:21:18 2002","24379846","","","","","","1","","","SMU.1447c","391" "SMu1319","1378343","1379992","1650","ATGTCTTTTGATGGCTTTTTTTTACATCATTTAACAAAGGAATTACAAGAACAGATTCTTTGGGGGCGTATTCAGAAAGTAAACCAGCCTTTCGAACAAGAGCTAGTGTTGACGATTCGCAACAACAGGCAAAATTATAAACTGCTTCTTTCAGCCCACCCTGTCTTTGGCCGTGTTCAATTAACCAAGACCGATTTTCAAAATCCTCAAAGCCCTAATACTTTTACTATGATTATGCGAAAGTATCTGCAAGGAGCTCTTATCGAAAACATTGAACAAATTGAAAATGACCGTATTCTTGAAATGAGCATTTCCAATAAAAATGAAATTGGTGATCAAATCAAGGTTACTATGATTATTGAAATCATGGGGAAGCACAGTAATATTATTCTTTTAGATAAAAATGAAGGAAAAATTACTGAATCCATTAAACACATTGGCTTCACTCAAAACAGTTACCGCACTATTTTACCTGGCTCAAGATATTTAGCACCACCGAAAATACAGGCCCAAAACCCTTTTACCATTTCTGATGAAACATTATTTGAAATCCTACAAACAGAAGATTTAGCGGCTAATAATTTACAAAAACTCTTTCAGGGCTTAGGACGCGACACGGCTGCCGAATTGAGCCAAAGATTAAAAACTGACACATTCAAAAACTTTAAACTGTTTTTTGACTCGCCAACTTCTCCAACTTTGACTGAAAAATCTTTTACTGCAATTACTTTCAGCAATTCCCAAGAAACCTTTGGTAGCCTGTCAGATCTGCTTGACTATTTCTATCAAGATAAGGCTGAACGCGACAGAATTGCACAGCAAGCCAGCGATCTTATCCATCGTATTCAAAATGAATTAGAGAAAAACAAGAAAAAACTCAAAAAGCAAGAGCAAGAATTGCAAGATACAGATAAGGCTGAAGAGTTCCGCCAAAAAGGAGAACTTTTGACCACTTATCTTAATCAGGTCCCTAACAATCAGGACAGTGTTGAACTGGATAATTATTATACGGGACAAAAAGTAAGCATTCCGCTTAATAAAGCCTTGACACCTAGTCAAAATGCGCAACGCTATTTTAAAAAATATCAAAAATTAAAAGAAGCTGTGAAGCATTTAGGGAGCCTCATCAGCGAAACAAAGGCTACTATTCAATACTTAGAAAGTGTTGACAATGCCCTCAATCAGGCCAGCCTGTCTGAAATCAGCGAAATTCGTGAAGAGCTGGTTCAAACAGGTTTTGTCAAGCGCCGCCATCGTGAAAAAATTCAAAAACGCAAAAAACCTGAACCTTACTTAGCTTCTGATGGCAAAACCATCATTCTGGTTGGAAAGAATAACCTTCAAAATGACGAGCTAACTTTCAAAATGTCTAAAAAAGGGGAGCTCTGGTTCCATGCCAAAGACATTCCAGGAAGCCATGTTTTGATTAAAGATAACCTTAACCCTAGCGACGAAATTAAAACGGATGCTGCCGAATTAGCAGCTTACTTTTCAAAGGCTCGCCTTTCCAATCTTGTCCAAGTTGATATGATTGAAGCTAAAAAGCTCAACAAACCCAGCAAAGCCAAACCCGGTTTTGTCACTTATAGGGGACAAAAAACGTTGCGCGTAACGCCTAATGAAGCTAAGATAAAAGCGATGAAGATGTAA","10.00","13.46","63132","MSFDGFFLHHLTKELQEQILWGRIQKVNQPFEQELVLTIRNNRQNYKLLLSAHPVFGRVQLTKTDFQNPQSPNTFTMIMRKYLQGALIENIEQIENDRILEMSISNKNEIGDQIKVTMIIEIMGKHSNIILLDKNEGKITESIKHIGFTQNSYRTILPGSRYLAPPKIQAQNPFTISDETLFEILQTEDLAANNLQKLFQGLGRDTAAELSQRLKTDTFKNFKLFFDSPTSPTLTEKSFTAITFSNSQETFGSLSDLLDYFYQDKAERDRIAQQASDLIHRIQNELEKNKKKLKKQEQELQDTDKAEEFRQKGELLTTYLNQVPNNQDSVELDNYYTGQKVSIPLNKALTPSQNAQRYFKKYQKLKEAVKHLGSLISETKATIQYLESVDNALNQASLSEISEIREELVQTGFVKRRHREKIQKRKKPEPYLASDGKTIILVGKNNLQNDELTFKMSKKGELWFHAKDIPGSHVLIKDNLNPSDEIKTDAAELAAYFSKARLSNLVQVDMIEAKKLNKPSKAKPGFVTYRGQKTLRVTPNEAKIKAMKM","1380001","","fibronectin-binding, fibrinogen-binding protein-A","Cytoplasm","Several hits in gapped BLAST to fibronectin-binding protein A. Residues 1-549 are 70% similar to gi15675016 inS.pyogenes. Residues 1-548 are 67% similar to gi15902912 in S.pneumoniae .The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1190 (0.0).","

InterPro
IPR008532
Domain

Protein of unknown function DUF814
PF05670	$\"[431-518]T$	DUF814

InterPro
IPR008616
Domain

Fibronectin-binding A, N-terminal
PF05833	$\"[1-427]T$	FbpA

","BeTs to 10 clades of COG1293COG name: Fibronectin-binding protein (function unknown)Functional Class: MThe phylogenetic pattern of COG1293 is amtky-vc-b--uj--o----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 431-519 are 88% similar to a (PROTEOME COMPLETE) protein domain (PD009236) which is seen in P95752_STRGN.Residues 306-393 are 30% similar to a (PROTEOME COMPLETE) protein domain (PD415650) which is seen in P73561_SYNY3.Residues 265-427 are 61% similar to a (PROTEOME COMPLETE FIBRONECTIN-BINDING A) protein domain (PD133744) which is seen in P95752_STRGN.Residues 73-213 are 25% similar to a (PROTEOME FIBRONECTIN/FIBRINOGEN-BINDING) protein domain (PD322951) which is seen in Q9RWV6_DEIRA.Residues 146-264 are 62% similar to a (A FIBRONECTIN-BINDING COMPLETE PLASMID) protein domain (PD257617) which is seen in P95752_STRGN.Residues 6-145 are 73% similar to a (PROTEOME COMPLETE FIBRONECTIN-BINDING) protein domain (PD007027) which is seen in P95752_STRGN.Residues 247-424 are 58% similar to a (FIBRONECTIN/FIBRINOGEN-BINDING PROTEOME) protein domain (PD075266) which is seen in Q54858_STRPY.Residues 167-246 are 45% similar to a (FIBRONECTIN/FIBRINOGEN-BINDING) protein domain (PD155959) which is seen in Q54858_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 13:28:21 2002","Sun Oct 27 20:53:07 2002","Thu Aug 10 08:52:09 2006","Mon Mar 11 13:25:44 2002","","Mon Mar 11 13:25:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1319 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 13:28:21 2002","","No significant hits to the NCBI PDB database.","SMU.1449","","Residues 1 to 427 (E-value = 9.1e-229) place SMu1319 in the FbpA family which is described as Fibronectin-binding protein A N-terminus (FbpA) (PF05833)Residues 431 to 518 (E-value = 4.3e-37) place SMu1319 in the DUF814 family which is described as Domain of unknown function (DUF814) (PF05670)","Thu Aug 10 08:52:09 2006","24379847","","","Courtney,H.S., Li,Y., Dale,J.B. and Hasty,D.L.Cloning, sequencing, and expression of afibronectin/fibrinogen-binding protein from group A streptococciInfect. Immun. 62 (9), 3937-3946 (1994)PubMed: 8063411","","Mon Mar 11 13:28:21 2002","1","","","SMU.1449","132" "SMu1320","1380297","1381694","1398","ATGTCACATCAAAATGCAAAAAATACAACACAGAATCCGAAAGAGCTTGAGAATGGCATGGTTCGTGGCTTACAAAATCGCCATGTGCAATTGATTGCCATTGCCGGAACCATCGGAACAGGGCTTTTTTTAGGAGCAGGGCGTTCCATTTCATTAACAGGCCCTTCCATCATCATCGTTTATCTCTTAACAGGACTTTTCATGTTTTGGATGATGCGTGCGATGGGTGAAATGCTTTACCATGATCCTGATCAGCATACTTTTATCAATTTTATTACCAAATACATTGGTAAAGAATGGGGTTATTTCGCAGGTTGGTCCTATTGGGTATCTGTCATTTTCTTAGGAATGGCGGAAATCACAGCTATCGCCAAATATGTTCAGTACTGGTTTCCATCTTGGCCTGCTTGGATAATTCAGATTGTTTTTCTTTTAATATTAGGATCTGTTAATTTAATTGCTGTTCGTGTTTTTGGCGAAGCAGAATTCTGGTTTGCCATGATTAAAATCATTGCCATCTTAGCATTGATTGCAACAGCTATCTTCATGTTACTGACTGGTTTTAAAACGAGTCAGGGACCAGTTAGTTTTGCCAATATTTCTAAGGGATTTGAAATGTTTCCCAATGGTTGGATGAAATTTCTCATGTCTTTCCAAATGGTCTTCTTTGCTTATCAGGCTATTGAATTTGTTGGGATTACCGTATCCGAGACACAAAATCCAAGAAAGGTTTTACCAAAAGCTATCCAAGAAATTCCAATGCGAATTGTGATTTTTTATGTCGGTGCCTTAATTGCTATTATGACCATTTTCCCATGGAGAGCATTGCCATCAGATACATCACCATTTGTCATGGTCTTCAAACTGGCGGGTATCAAATGGGCGGCTGCCTTAATCAACTTTGTTGTGCTAACTTCCGCAGCGTCTGCTCTAAACTCGACACTCTATTCAACTGGTCGTCACCTTTATCAATTAGCTAATGAAGCACCTAATCAATTTATGAAACGCTTCAAAATCGGAACACTTTCAAAAACTGGTGTCCCAAGTAAAGCCATTATTTTCTCAGCTATTGTTATTGCTATTTCAGCTTTTATCAATGTACTGCCTGGAATAAAAGACGCTTTTGCTTTGATTACTGCGTCTTCTTCTGGTGTTTACATTGCCATTTATGTTTTGACCATGCTGGCTCACCTGAAATATCGTAAATCAAACGATTTTATGGCAGATGGCTATTTAATGCCTCATTACAAAATTTTAAATCCTATCACAATTATTTTTATGGTCTTTGTTTTTATAACTTTGTTTTTACAGGACTCAACCTATATCGGAGCCATTGGAGCAACTATTTGGATTGCTGCCTTTGGTTTCTACAGTAAGTTTAAATTTAAAAAACAATAG","10.60","18.68","52136","MSHQNAKNTTQNPKELENGMVRGLQNRHVQLIAIAGTIGTGLFLGAGRSISLTGPSIIIVYLLTGLFMFWMMRAMGEMLYHDPDQHTFINFITKYIGKEWGYFAGWSYWVSVIFLGMAEITAIAKYVQYWFPSWPAWIIQIVFLLILGSVNLIAVRVFGEAEFWFAMIKIIAILALIATAIFMLLTGFKTSQGPVSFANISKGFEMFPNGWMKFLMSFQMVFFAYQAIEFVGITVSETQNPRKVLPKAIQEIPMRIVIFYVGALIAIMTIFPWRALPSDTSPFVMVFKLAGIKWAAALINFVVLTSAASALNSTLYSTGRHLYQLANEAPNQFMKRFKIGTLSKTGVPSKAIIFSAIVIAISAFINVLPGIKDAFALITASSSGVYIAIYVLTMLAHLKYRKSNDFMADGYLMPHYKILNPITIIFMVFVFITLFLQDSTYIGAIGATIWIAAFGFYSKFKFKKQ","1381703","","amino acid permease","Membrane, Cytoplasm","Matches in gapped BLAST to amino acid permeases: residues 7-463 are66% similar to gi|15675525| of S.pyogenes and residues 8-421 are 48% similar to gi|15672337| ofLactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1480 (1e-165).","

InterPro
IPR002293
Family

Amino acid/polyamine transporter I
PTHR11785	$\"[15-465]T$	AA/rel_permease1

InterPro
IPR004840
Family

Amino acid permease
PS00218	$\"[53-83]?$	AMINO_ACID_PERMEASE_1

InterPro
IPR004841
Domain

Amino acid permease-associated region
PF00324	$\"[28-463]T$	AA_permease

noIPR
unintegrated

unintegrated
PIRSF006060	$\"[18-465]T$	AA_transporter
PTHR11785:SF30	$\"[15-465]T$	PTHR11785:SF30

","BeTs to 3 clades of COG1113COG name: Gamma-aminobutyrate and related permeasesFunctional Class: EThe phylogenetic pattern of COG1113 is --------EBR----------Number of proteins in this genome belonging to this COG is 1","***** IPB002027 (Amino acid permease) with a combined E-value of 4.5e-41. IPB002027A 27-55 IPB002027B 151-170 IPB002027C 223-261 IPB002027D 305-344","Residues 6-83 are 37% similar to a (AMINO-ACID TRANSPORT BASIC PERMEASE) protein domain (PD078127) which is seen in ALP1_YEAST.Residues 22-83 are 75% similar to a (TRANSPORT PERMEASE AMINO-ACID TRANSMEMBRANE PROTEOME) protein domain (PD284669) which is seen in Q9CIK2_LACLA.Residues 94-164 are 50% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME AMINO AMINO-ACID) protein domain (PD031626) which is seen in Q9S2G7_STRCO.Residues 87-164 are 50% similar to a (TRANSPORT AMINO-ACID PERMEASE) protein domain (PD362960) which is seen in YBXG_BACSU.Residues 84-224 are 39% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD397739) which is seen in Q9CIK2_LACLA.Residues 283-375 are 49% similar to a (TRANSPORT PERMEASE AMINO-ACID TRANSMEMBRANE COMPLETE) protein domain (PD000262) which is seen in Q9CIK1_LACLA.Residues 225-282 are 58% similar to a (TRANSPORT AMINO ACID AMINO-ACID PERMEASE TRANSMEMBRANE) protein domain (PD000442) which is seen in Q9CIK1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 13:33:26 2002","Mon Mar 11 13:32:38 2002","Thu Oct 17 16:52:57 2002","Mon Mar 11 13:32:38 2002","Mon Mar 11 13:32:38 2002","Mon Mar 11 13:32:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1320 is paralogously related (blast p-value < 1e-3) to SMu0863, SMu0014, and SMu0239, all predicted amino acid permeases.","Mon Mar 11 13:33:26 2002","","No significant hits to the NCBI PDB database.","SMU.1450","","Residues 28 to 465 (E-value = 8.6e-89) place SMu1320 in the AA_permease family which is described as Amino acid permease (PF00324)","Mon Mar 11 13:32:38 2002","24379848","","","","","","1","","","SMU.1450","157" "SMu1321","1382481","1381765","717","ATGGAAACCAACAAATTATTTCAATATAATACCTTAGGAGCGCTTATGGCAGGTCTCTATGATGGTTCTTTAACTGTGGGTGAGCTGTTAGAATATGGAGATTTAGGTTTAGGAACACTTGATTCCATTGATGGTGAATTAATTGTCCTAGATGGTAAAGCTTATCAGGCTAAAGGATCTGGTGATAAACCAGAAGTTGTTGAAGTGCCTGATGATATGAAAGTGCCTTATGCAGCTGTCATTCATCATGAAGCAGAGGTTATTTTTAAGCAGCGTTTTGAAATGACAGATAAAGAATTGCAAGAACGTATTGAGTCTTACTATGATGGGGAGAATCTCTTTCGTTCGATTAAAATTCACGGAACCTTTGCTAAAATGCATGTACGTATGATTCCGCGTTCGACCCCTGATGAGAAATTTGCAGAAGTGGCAACACATCAGCCAGAATACAGAGCCGAAAATATTACCGGTACTATTGTTGGTATTTGGACGCCTGAAATTTTTCATGGTGTCAGTGTGGCTGGTTATCATTTGCACTTTATTTCTGATGATCATACTTTTGGTGGCCATGTTATGGACTATGTTATTTCAGAAGGGCAGGTTGAAGTGGGTGCTGTTGATCAGTTAGATCAACGTTTCCCCGTTCAAGATCGGCAATATCTCTTTGCTAAATTTAACGCCAAAGATATTCGTGGTGATATTGACAAGGCAGAATAG","4.60","-16.57","26762","METNKLFQYNTLGALMAGLYDGSLTVGELLEYGDLGLGTLDSIDGELIVLDGKAYQAKGSGDKPEVVEVPDDMKVPYAAVIHHEAEVIFKQRFEMTDKELQERIESYYDGENLFRSIKIHGTFAKMHVRMIPRSTPDEKFAEVATHQPEYRAENITGTIVGIWTPEIFHGVSVAGYHLHFISDDHTFGGHVMDYVISEGQVEVGAVDQLDQRFPVQDRQYLFAKFNAKDIRGDIDKAE","1381780","For other 'ald' genes see SMu1195 (aldR).","alpha-acetolactate decarboxylase","Cytoplasm, Extracellular","Several matches in gapped BLAST to alpha-acetolactate decarboxylase: residues 2-238 are 75% similar to the enzyme in S.pneumoniae (gi|15903292|) are 65% similar to theprotein from Lactococcus lactis (gi|1524117|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1191 (8e-77).","

InterPro
IPR005128
Family

Alpha-acetolactate decarboxylase
PD006931	$\"[111-238]T$	Acetolac_decarb
PIRSF001332	$\"[1-238]T$	Acetolac_decarb
PF03306	$\"[1-229]T$	AAL_decarboxy
TIGR01252	$\"[4-238]T$	acetolac_decarb

noIPR
unintegrated

unintegrated
G3DSA:3.30.1330.80	$\"[81-205]T$	G3DSA:3.30.1330.80

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-220 are 67% similar to a (DECARBOXYLASE ALPHA-ACETOLACTATE LYASE) protein domain (PD006931) which is seen in P77880_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Oct 18 07:39:01 2002","Mon Mar 11 13:36:43 2002","Thu Oct 17 16:52:23 2002","Mon Mar 11 13:36:43 2002","","Mon Mar 11 13:36:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1321 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 13:43:37 2002","","No significant hits to the NCBI PDB database.","SMU.1451c","","Residues 1 to 229 (E-value = 5.5e-113) place SMu1321 in the AAL_decarboxy family which is described as Alpha-acetolactate decarboxylase (PF03306)","Mon Mar 11 13:36:43 2002","","","","Goupil-Feuillerat,N., Cocaign-Bousquet,M., Godon,J.J., Ehrlich,S.D.and Renault,P. Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp. lactis J. Bacteriol. 179 (20), 6285-6293 (1997) PubMed: 9335274 Swindell,S.R., Benson,K.H., Griffin,H.G., Renault,P., Ehrlich,S.D.and Gasson,M.J.Genetic manipulation of the pathway for diacetyl metabolism inLactococcus lactisAppl. Environ. Microbiol. 62 (7), 2641-2643 (1996)PubMed: 8779601Goupil,N., Corthier,G., Ehrlich,S.D. and Renault,P.Imbalance of leucine flux in Lactococcus lactis and its use for the isolation of diacetyl-overproducing strainsAppl. Environ. Microbiol. 62 (7), 2636-2640 (1996)PubMed: 8779600","","Fri Oct 18 07:39:01 2002","1","","","SMU.1451c","573" "SMu1322","1384174","1382495","1680","ATGACCGAAATAAATAAGGAAGGCTATGGGGCTGACCTGATTGTAGACAGCCTCATTAATCATGATGTCAACTATGTTTTTGGAATCCCTGGTGCAAAAATTGATCGTGTCTTTGATACCTTAGAAGATAAGGGGCCAGAACTTATTGTAGCACGCCATGAGCAAAATGCTGCTTTTATGGCTCAAGGAATTGGCCGTATTACTGGTGAGCCTGGTGTTGTGATTACAACCAGCGGTCCCGGTGTTTCCAATCTGGTGACTGGTCTTGTTACTGCGACAGCTGAGGGAGATCCTGTCCTTGCTATTGGTGGTCAGGTTAAACGTGCTGATTTGCTCAAACGGGCTCACCAGTCAATGAATAATGTTGCTATGCTCGATCCCATTACCAAATATTCAGCAGAAATTCAGGATCCCGCAACACTTTCAGAAAATATTGCTAATGCCTATCGTTTGGCTAAAGCAGGAAAGCCGGGAGCTAGTTTCTTATCTATTCCTCAAGATATAACTGATAGTCCTGTTACTGTCAAGGCGATTAAGCCCTTGACAGATCCTAAACTAGGTTCAGCGTCAGTTGCTGATATTAATTATTTGGCACAGGCCATAAAAAATGCGGTCCTTCCTGTCTTACTTTTAGGAAATGGTGCGTCAACGGCTGCAGTTACAGCTTCTATTCGCCGTTTGTTAGGAGCTGTCAAGCTGCCAGTCGTTGAAACTTTCCAAGGAGCTGGTATTGTTTCAAGAGATTTAGAAGAGGACACTTTTTTTGGTCGTGTGGGGCTTTTTCGTAATCAGCCCGGAGATATGTTGCTGAAGCGTTCTGACTTAGTTATCGCTATTGGCTATGATCCTATTGAATATGAAGCGCGCAATTGGAATGCTGAAATTTCGGCTCGCATTATCGTTATTGATGTTGCTCCAGCTGAAATTGATACTTATTTCCAACCTGAACGTGAATTAATTGGTGATATAGCTGAAACACTTGATTTACTCCTACCTGCTATTAGTGGCTACTCACTTCCAAAAGGTTCTCTTGACTATCTCAAAGGCCTTCGTGATAATGTAGTAGAAGATGTCAAATTTGATAAGACAGTCAAATCCGGTCTGGTTCATCCGCTTGATGTGATTGATGTCCTTCAAAAGCAAACGACTGATGATATGACAGTAACGGTTGATGTTGGCAGCCATTATATTTGGATGGCTCGTTATTTTAAAAGCTATGAAGCACGGCACTTACTTTTCTCAAATGGTATGCAAACCTTAGGTGTTGCTTTGCCTTGGGCAATTTCGGCAGCTCTTGTACGGCCAAATGAGAAGATTATTTCTATTTCAGGTGATGGTGGTTTCCTCTTTTCTGGCCAAGAATTGGAAACAGCTGTTCGTTTACATTTACCAATTGTTCATATCATTTGGAATGATGGTAAATATAATATGGTTGAATTCCAAGAAGAAATGAAATACGGCCGTTCAGCAGGTGTTGATTTTGGTCCTGTTGATTTTGTCAAGTATGCTGATAGTTTCGGTGCTAAAGGTTACCGTGCTGATAGTAAAGAAAAGTTTGATCAAGTTCTTCAAACAGCACTCAAGGAAGCTGCAAATGGCCCAGTTCTCATTGATGTTCCAATGGACTATAAAGATAATGTAAAATTGGGTGAAACTATTTTGCCTGATGAATTCTACTAA","4.70","-19.02","60719","MTEINKEGYGADLIVDSLINHDVNYVFGIPGAKIDRVFDTLEDKGPELIVARHEQNAAFMAQGIGRITGEPGVVITTSGPGVSNLVTGLVTATAEGDPVLAIGGQVKRADLLKRAHQSMNNVAMLDPITKYSAEIQDPATLSENIANAYRLAKAGKPGASFLSIPQDITDSPVTVKAIKPLTDPKLGSASVADINYLAQAIKNAVLPVLLLGNGASTAAVTASIRRLLGAVKLPVVETFQGAGIVSRDLEEDTFFGRVGLFRNQPGDMLLKRSDLVIAIGYDPIEYEARNWNAEISARIIVIDVAPAEIDTYFQPERELIGDIAETLDLLLPAISGYSLPKGSLDYLKGLRDNVVEDVKFDKTVKSGLVHPLDVIDVLQKQTTDDMTVTVDVGSHYIWMARYFKSYEARHLLFSNGMQTLGVALPWAISAALVRPNEKIISISGDGGFLFSGQELETAVRLHLPIVHIIWNDGKYNMVEFQEEMKYGRSAGVDFGPVDFVKYADSFGAKGYRADSKEKFDQVLQTALKEAANGPVLIDVPMDYKDNVKLGETILPDEFY","1382510","","alpha-acetolactate synthase","Cytoplasm","Several matches in gapped BLAST to alpha-acetolactate synthase: residues 4-559 are 69% similar to the enzyme in Lactococcus lactis (gi|15673166|). Residues 5-558 are 558 similar to the protein from S.aureus (gi|15925197|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1192 (0.0).","

InterPro
IPR000399
Family

TPP-binding enzymes
PIRSF001370	$\"[10-556]T$	ThDP_depend_acl
PS00187	$\"[428-447]?$	TPP_ENZYMES

InterPro
IPR011766
Domain

Thiamine pyrophosphate enzyme, C-terminal TPP-binding
PF02775	$\"[391-539]T$	TPP_enzyme_C

InterPro
IPR012000
Domain

Thiamine pyrophosphate enzyme, central region
PF00205	$\"[194-330]T$	TPP_enzyme_M

InterPro
IPR012001
Domain

Thiamine pyrophosphate enzyme, N-terminal TPP binding region
PF02776	$\"[8-177]T$	TPP_enzyme_N

InterPro
IPR012782
Family

Acetolactate synthase, catabolic
TIGR02418	$\"[10-551]T$	acolac_catab

InterPro
IPR012846
Family

Acetolactate synthase, large subunit, biosynthetic
PIRSF500108	$\"[8-559]T$	Acetolac_syn_lg

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1220	$\"[194-335]T$	G3DSA:3.40.50.1220
G3DSA:3.40.50.970	$\"[9-191]T$ $\"[342-555]T$	G3DSA:3.40.50.970
PTHR18968	$\"[234-554]T$	PTHR18968
PTHR18968:SF11	$\"[234-554]T$	PTHR18968:SF11
SSF52467	$\"[159-390]T$	SSF52467
SSF52518	$\"[7-185]T$ $\"[364-548]T$	SSF52518

","BeTs to 10 clades of COG0028COG name: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]Functional Class: E,HThe phylogenetic pattern of COG0028 is AMT-YqvCEBRH---------Number of proteins in this genome belonging to this COG is 2","***** IPB000399 (Thiamine pyrophosphate dependent enzyme) with a combined E-value of 4.5e-46. IPB000399A 18-41 IPB000399B 53-66 IPB000399C 77-100 IPB000399D 259-288 IPB000399E 418-457","Residues 420-539 are 38% similar to a (SYNTHASE THIAMINE DEHYDROGENASE PYROPHOSPHATE PYRUVATE) protein domain (PD000580) which is seen in O28180_ARCFU.Residues 117-212 are 45% similar to a (SYNTHASE LYASE FLAVOPROTEIN PYROPHOSPHATE) protein domain (PD403175) which is seen in P94896_OENOE.Residues 163-212 are 74% similar to a (PYROPHOSPHATE THIAMINE SYNTHASE) protein domain (PD290528) which is seen in Q48634_LACLA.Residues 116-376 are 24% similar to a (CARBOXYETHYLARGININE SYNTHASE) protein domain (PD358099) which is seen in Q9RIW1_STRCL.Residues 416-541 are 33% similar to a (SYNTHASE ACETOLACTATE FLAVOPROTEIN) protein domain (PD407122) which is seen in Q59317_BBBBB.Residues 10-162 are 73% similar to a (SYNTHASE THIAMINE PYROPHOSPHATE FLAVOPROTEIN LYASE) protein domain (PD000376) which is seen in Q48634_LACLA.Residues 419-542 are 70% similar to a (SYNTHASE THIAMINE PYROPHOSPHATE FLAVOPROTEIN LYASE) protein domain (PD000397) which is seen in Q48634_LACLA.Residues 420-528 are 33% similar to a (PYROPHOSPHATE THIAMINE FLAVOPROTEIN) protein domain (PD401189) which is seen in Q9ZFZ4_STROR.Residues 310-415 are 57% similar to a (SYNTHASE FLAVOPROTEIN PYROPHOSPHATE) protein domain (PD308185) which is seen in Q48634_LACLA.Residues 216-309 are 76% similar to a (SYNTHASE LYASE THIAMINE FLAVOPROTEIN) protein domain (PD039464) which is seen in Q48634_LACLA.Residues 420-539 are 33% similar to a (DECARBOXYLASE PYRUVATE THIAMINE) protein domain (PD401689) which is seen in Q9HUR2_PSEAE.Residues 117-170 are 50% similar to a (SYNTHASE THIAMINE PYROPHOSPHATE) protein domain (PD007687) which is seen in O05225_BACSU.Residues 110-162 are 52% similar to a (LYASE PYROPHOSPHATE FLAVOPROTEIN THIAMINE) protein domain (PD382689) which is seen in Q9ZIA9_LEULA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 13:50:21 2002","Mon Mar 11 13:48:49 2002","Thu Oct 17 16:51:07 2002","Mon Mar 11 13:48:49 2002","Fri Jan 4 11:48:19 2002","Fri Jan 4 11:48:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1322 is paralogously related (blast p-value < 1e-3) to SMu0209, a predicted acetolactate synthase, large subunit (AHAS).","Mon Mar 11 13:48:49 2002","Fri Jan 4 11:48:19 2002","pdb|1POX|A Chain A, Pyruvate Oxidase (E.C.1.2.3.3) Mutant With ... 173 5e-044pdb|1POW|A Chain A, Pyruvate Oxidase (E.C.1.2.3.3) (Wild Type) ... 173 5e-044pdb|1BFD| Benzoylformate Decarboxylase From Pseudomonas Putida 113 4e-026","SMU.1452c","","Residues 8 to 177 (E-value = 3.9e-65) place SMu1322 in the TPP_enzyme_N family which is described as Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (PF02776)Residues 193 to 350 (E-value = 8.8e-32) place SMu1322 in the TPP_enzyme_M family which is described as Thiamine pyrophosphate enzyme, central domain (PF00205)","Fri Jan 4 11:48:19 2002","","","","Garmyn,D.,Monnet,C.,Martineau,B., Guzzo,J.,Cavin,J.F.and Divies,C.Cloning and sequencing of the gene encoding alpha-acetolactatedecarboxylase from Leuconostoc oenosFEMS Microbiol. Lett. 145 (3), 445-450 (1996)PubMed: 8978099","","Mon Mar 11 13:52:17 2002","1","","","SMU.1452c","133" "SMu1323","1385290","1384307","984","ATGTATTTAGATGTTATCGAACCTGATCATCCCGATTATTTGACAGCATTGTTAGTTAAGGCAGATTTGTATGATACAGAAGGATTAACAGAAGTTGCCAGAGAAAAATTATTAGAAGCTAGCCAAATTAGCCAAGAGCCCTTGGTCATCTTTGGTTTAGCAGAGATTGAAATGAATTTATCGGATTTTCAAGCAGCCATCCAGCATTATGCTCAATTGGATAACCGTGCGATTTTAGAAGAGACAGGTGTTTCTACTTATGAGAGAATTGGACGTGCCTATGCTAGCTTAGGAAAGTTTGAAACAGCTATTGAATTTCTCGAAAAGGCAGTAGAAATTGAATTTGATGAAACAACTGTTTTTGAGGTTGCAACTTTACTCTATGATCAAGAAGAATACCAAAGAGCCAATCTTTATTTTAAGCAGTTAGACAGTATGAATCCTGATTTCGCAGGATATGAATACAATTATGCTCTTTCGCTTCATGCAGAACATCAAACGAAGCAGGCCTTGCGTATGCTGCAACAGGGATTATCAAAGAATGAATTTGACAGTCAGCTCCTCCTTTTAGCTTCACAATTATCCTATGAACTGCATGATAAAAAAGCCGCCGAAAATTACCTTCTGAAAGTTTTAGAAACAGCAGAAGATGATGAAGAAGCCCTTATGAGACTTAGCAATCTTTACTTAGAAGAGAATCGTTTTGAAGATGTGATCAATTTAGACAGAGCAGATATTGATAGTGTGCTGACAAAGTGGAATATAGCTAAGGCTTACCAGAAACTTGAAGCTGACACAAAAGCTCTTGAGATTTATGATACTTTAATCGTAGATTTGGCTGATAATCCAGACTTTCTTAAGGATTATATCTATATTTTGCGAAAATTCGGTTATGATGAAAAAGTTAAAACTTTTGCCGATAAATACTTACAATTAGTACCTGACGATAATGATATTGCCGATTTGCGAGAGCAATTGCAGTAA","4.10","-35.74","37850","MYLDVIEPDHPDYLTALLVKADLYDTEGLTEVAREKLLEASQISQEPLVIFGLAEIEMNLSDFQAAIQHYAQLDNRAILEETGVSTYERIGRAYASLGKFETAIEFLEKAVEIEFDETTVFEVATLLYDQEEYQRANLYFKQLDSMNPDFAGYEYNYALSLHAEHQTKQALRMLQQGLSKNEFDSQLLLLASQLSYELHDKKAAENYLLKVLETAEDDEEALMRLSNLYLEENRFEDVINLDRADIDSVLTKWNIAKAYQKLEADTKALEIYDTLIVDLADNPDFLKDYIYILRKFGYDEKVKTFADKYLQLVPDDNDIADLREQLQ","1384322","","conserved hypothetical protein, tetratricopeptide repeat family","Cytoplasm, Extracellular","Limited matches in gapped BLAST to conserved hypothetical protein: residues 1-327 are 62% similar to S.pyogenes (gi15675015) and residues 2-326 are 55% similar to S.pneumoniae (gi15903399).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1193 (1e-109).","

InterPro
IPR001440
Repeat

Tetratricopeptide TPR_1
PF00515	$\"[84-117]T$	TPR_1

InterPro
IPR011990
Domain

Tetratricopeptide-like helical
G3DSA:1.25.40.10	$\"[10-241]T$	TPR-like_helical

InterPro
IPR013026
Domain

Tetratricopeptide region
PS50005	$\"[84-117]T$	TPR
PS50293	$\"[84-240]T$	TPR_REGION

noIPR
unintegrated

unintegrated
PTHR23083	$\"[1-319]T$	PTHR23083
PTHR23083:SF15	$\"[1-319]T$	PTHR23083:SF15
SSF48452	$\"[10-319]T$	SSF48452

","BeTs to 11 clades of COG0457COG name: TPR-repeat-containing proteinsFunctional Class: RThe phylogenetic pattern of COG0457 is AMTKYQVCEB-HUJ--OLINXNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 2-154 are 43% similar to a (REPEAT COMPLETE PROTEOME TPR) protein domain (PD061916) which is seen in Q9CGB4_LACLA.Residues 3-150 are 29% similar to a (PROTEOME COMPLETE BH1669 QCRA-AROE) protein domain (PD116248) which is seen in Q9KCA4_BACHD.Residues 157-327 are 37% similar to a (PROTEOME COMPLETE YLJJ) protein domain (PD399459) which is seen in Q9CGB4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 13:48:24 2006","Wed Sep 13 13:48:24 2006","Wed Sep 13 13:48:24 2006","Mon Mar 11 13:55:33 2002","","Mon Mar 11 13:55:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1323 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Sep 13 13:48:24 2006","","No significant hits to the NCBI PDB database.","SMU.1453c","","Residues 84 to 117 (E-value = 8e-05) place SMu1323 in the TPR family which is described as TPR Domain (PF00515)","Mon Mar 11 13:55:33 2002","24379851","","","","","","1","","","SMU.1453c","392" "SMu1324","1386698","1385529","1170","GTGAATAAAAAAAATGAAAAATTTAATCTTTCTTGGTTTTTTAAATGGTTCTTGGATAATAAAACCGTAACGGTCTTATTGGTTTTACTTTTAGTCTTTTTGGATATTCTTGTTTTTACCAAGATTAGTTCTATTTTTAAACCTCTTCTTTCTTTTTTAGCTGTTATCATGTTACCTTTGGTAATTTCAGCCTTACTTTACTACCTTTTAAAGCCTATTGTGGATTTTATTGAAAGACGGGGAACTAGCCGTGTGATGGCTATTACAATTGTCTTTGTTATCATAGCAGGACTTCTTGTTTGGGGCATAGCCAATTTCTTTCCCATGCTTAATGAGCAACTAACCTCTTTTATTAAATACTTACCAAGTTATGTCAGGTCTGTAGATGCTCAGGTTTCAAAATTGTTGAGGAACGATTTGCTGGCTAGTTTTCGACCGCAAATTGAAGATGCAGTAACTAATTTTAGCCAGAAGGCTGTTGATTATGCGGAAACTTTTTCTAAAGGAGCAGTAACTTGGGCTGGAAATTTTGCATCGCTAATTGCACGTGTTACAGTAGCTATTATAATTTCTCCTTTCATTGTTTTTTATCTTTTACGTGATAGCAGTAAGATGAAAGAAGCTTTTGTATCTTATTTGCCTACTAAAATGCGTCAGCCCATTCATCGTATTTTGGGAGATGTTAATCGGCAGCTGGCTGGTTATGTTCAAGGTCAAGTGACTGTTGCGATTATTGTTGGTTTTATGTTTTCCATTATGTTCACGATTATTGGTTTGCGCTATGCAGTGACCTTTGGGATTATAGCGGGATTTTTAAATATGATTCCTTATCTAGGAAGCTTTTTAGCAACGATACCAGTTTTTATTTTGGCTCTCGTTGAAGGACCTGTTATGGTGGTGAAGGTAGCGCTTGTTTTTATTGTTGAACAAACCATTGAAGGGCGCTTTGTCTCTCCACTTGTTCTTGGCAGCAAACTTAGTATTCATCCCATTACCATTATGTTTATTTTATTGACAGCAGGCTCAATGTTTGGTGTTTGGGGAGTTTTTTTGGGAATTCCTGTTTATGCATCAATTAAGGTTGTCGTCAAAGAAATTTTTGAATGGTATAAGCCTATTAGTGGCCTGTATGAGAAAGAAGAGGAGGATATTAAGAAAGATGTTAAATAG","10.40","11.48","43781","MNKKNEKFNLSWFFKWFLDNKTVTVLLVLLLVFLDILVFTKISSIFKPLLSFLAVIMLPLVISALLYYLLKPIVDFIERRGTSRVMAITIVFVIIAGLLVWGIANFFPMLNEQLTSFIKYLPSYVRSVDAQVSKLLRNDLLASFRPQIEDAVTNFSQKAVDYAETFSKGAVTWAGNFASLIARVTVAIIISPFIVFYLLRDSSKMKEAFVSYLPTKMRQPIHRILGDVNRQLAGYVQGQVTVAIIVGFMFSIMFTIIGLRYAVTFGIIAGFLNMIPYLGSFLATIPVFILALVEGPVMVVKVALVFIVEQTIEGRFVSPLVLGSKLSIHPITIMFILLTAGSMFGVWGVFLGIPVYASIKVVVKEIFEWYKPISGLYEKEEEDIKKDVK","1385544","","conserved hypothetical protein, possible permease","Membrane, Cytoplasm","This sequence corresponds to the previously published gi4098497 and gi2952526; a predicted membrane protein and a permease respectively in GenBank. Significant hits in gapped BLAST to membrane protein and permeases. Residues 1-377 are 92% similar to gi4098497 as seen in S. mutans.Residues 41-371 are 28% similar to gi2952526 as seen in S. mutans.Residues 1-377 are 54% similar to gi15901352 as seen in S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1194 (1e-131).","

InterPro
IPR002549
Family

Protein of unknown function UPF0118
PTHR21716	$\"[113-370]T$	TRANSMEMBRANE PROTEIN
PF01594	$\"[33-367]T$	UPF0118

noIPR
unintegrated

unintegrated
signalp	$\"[1-64]?$	signal-peptide
tmhmm	$\"[21-43]?$ $\"[49-69]?$ $\"[84-104]?$ $\"[179-199]?$ $\"[231-251]?$ $\"[257-277]?$ $\"[287-307]?$ $\"[331-351]?$	transmembrane_regions

","BeTs to 14 clades of COG0628COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0628 is amtK-qVCEBRHuj--ol--xNumber of proteins in this genome belonging to this COG is 3","***** IPB002549 (Domain of unknown function DUF20) with a combined E-value of 2.3e-17. IPB002549A 22-34 IPB002549B 319-356","Residues 45-113 are 37% similar to a (PROTEOME COMPLETE TRANSMEMBRANE PERMEASE) protein domain (PD132771) which is seen in YUBA_BACSU.Residues 3-67 are 33% similar to a (PROTEOME COMPLETE YLJH) protein domain (PD387868) which is seen in Q9CGB6_LACLA.Residues 116-363 are 46% similar to a (TRANSMEMBRANE COMPLETE PROTEOME PERMEASE INTEGRAL) protein domain (PD002159) which is seen in Q9CGB5_LACLA.Residues 53-122 are 32% similar to a (PROTEOME COMPLETE MEMBRANE INTEGRAL) protein domain (PD338787) which is seen in Q9PFR8_XYLFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 14:02:27 2002","Wed Sep 13 13:52:39 2006","Wed Sep 13 13:52:39 2006","Mon Mar 11 14:01:36 2002","Mon Mar 11 14:01:36 2002","Mon Mar 11 14:01:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1324 is paralogously related (blast p-value < 1e-3) to SMu1544, and SMu1006, both predicted permeases.","Mon Mar 11 14:02:27 2002","","No significant hits to the NCBI PDB database.","SMU.1454c","","Residues 33 to 367 (E-value = 3.3e-74) place SMu1324 in the UPF0118 family which is described as Domain of unknown function DUF20 (PF01594)","Mon Mar 11 14:01:36 2002","24379852","","","","Wed Sep 13 13:52:39 2006","","1","","","SMU.1454c","393" "SMu1325","1387246","1386767","480","ATGACAAAATTAGCAACAATTTGTTATATTGATAACGGGTGCGAGCTTTTATTGATGCATCGTAATAAAAAACCGAATGATGTTCATGAAGGCAAATGGATTAGTGTAGGTGGAAAATTGGAAAAAGGAGAGAGTCCTGATGAATGTGCCAGACGTGAAATTTTTGAGGAGACTCATTTAATTGTCAAACAAATGGATTTTAAAGGCATTATTACTTTTCCAGATTTCACACCGGGTCACGATTGGTATACTTATGTGTTTAAGGTAAGAGATTTTGAAGGTCGGTTGATTTCTGATAAAGACAGTCGTGAAGGAACGTTGGAATGGGTACCTTATAATCAGGTTTTAACTAAGCCAACATGGGAAGGCGACTATGAAATTTTTAAATGGATCTTAGACGATGCCCCCTTTTTCTCTGCCAAATTTGTTTATCAAGAGCAAAAGCTAGTTGATAAACATGTGATTTTTTATGAAAAATAG","5.40","-4.93","18834","MTKLATICYIDNGCELLLMHRNKKPNDVHEGKWISVGGKLEKGESPDECARREIFEETHLIVKQMDFKGIITFPDFTPGHDWYTYVFKVRDFEGRLISDKDSREGTLEWVPYNQVLTKPTWEGDYEIFKWILDDAPFFSAKFVYQEQKLVDKHVIFYEK","1386782","For other 'mut' genes associated with repair and DNA mutation, see Smu0510; SMu0024 (mutT); SMu1697 (mutY);SMu1700 (mutS2);SMu1291 (mutT); SMu1325 (mutX); SMu1371 (mutR); SMu1468 (mutM); SMu0824 (mutT) and SMu0825 (mutT).From Genbank:[gi:2497998]This protein is involved in the DNA repair system to avoid A.T to G.C transversions.It degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates. ","mutator mutX protein","Cytoplasm","Matches in gapped BLAST to MutX:residues 1-159 are 98% similar to the previously published enzyme in S.mutans (gi2497998) Residues 1-157 are 79% similar to the protein in S.pyogenes(gi15675013).Residues 1-158 are 68% similar to the protein from S.pneumoniae (gi15903098).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1196 (1e-79).","

InterPro
IPR000086
Domain

NUDIX hydrolase
PR00502	$\"[33-47]T$ $\"[47-62]T$	NUDIXFAMILY
G3DSA:3.90.79.10	$\"[2-159]T$	NUDIX_hydrolase
PF00293	$\"[2-134]T$	NUDIX
PS00893	$\"[38-59]T$	NUDIX

InterPro
IPR003562
Family

Mutator MutX
PR01402	$\"[4-22]T$ $\"[22-37]T$ $\"[68-94]T$ $\"[101-121]T$ $\"[121-138]T$ $\"[138-158]T$	MUTATORMUTX

InterPro
IPR015797
Domain

NUDIX
SSF55811	$\"[4-159]T$	NUDIX_hydrolase

noIPR
unintegrated

unintegrated
PTHR22769	$\"[6-132]T$	PTHR22769

","BeTs to 10 clades of COG0494COG name: NTP pyrophosphohydrolases (MutT family) including oxidative damage repair enzymesFunctional Class: L,RThe phylogenetic pattern of COG0494 is a-T-YqvCEBRHuj---linxNumber of proteins in this genome belonging to this COG is 6","***** IPB000086 (NUDIX hydrolase) with a combined E-value of 3.8e-12. IPB000086 33-59","Residues 81-158 are 98% similar to a (MUTATOR DNA DGTP MAGNESIUM) protein domain (PD029137) which is seen in MUTX_STRMU.Residues 4-136 are 36% similar to a (PROTEOME COMPLETE) protein domain (PD275416) which is seen in Q9PDW7_XYLFA.Residues 7-78 are 98% similar to a (COMPLETE PROTEOME HYDROLASE MUTATOR MUTT/NUDIX FAMILY) protein domain (PD000653) which is seen in MUTX_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:06:47 2005","Mon Mar 11 14:20:43 2002","Tue May 3 12:06:47 2005","Mon Mar 11 14:12:12 2002","Mon Mar 11 14:12:12 2002","Mon Mar 11 14:12:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1325 is paralogously related (blast p-value < 1e-3) to SMu1470,a predicted conserved hypothetical protein and SMu0738, a predicted mutator MutT protein.","Thu Mar 14 17:15:00 2002","","No significant hits to the NCBI PDB database.","SMU.1455c","","Residues 2 to 134 (E-value = 1.4e-25) place SMu1325 in the NUDIX family which is described as NUDIX domain (PF00293)","Mon Mar 11 14:12:12 2002","","","Tsukioka,Y., Yamashita,Y., Oho,T., Nakano,Y. and Koga,T.Biological function of the dTDP-rhamnose synthesis pathway inStreptococcus mutansJ. Bacteriol. 179 (4), 1126-1134 (1997)PubMed: 9023194","Mejean,V., Salles,C., Bullions,L.C., Bessman,M.J.and Claverys,J.P.Characterization of the mutX gene of Streptococcus pneumoniae as ahomologue of Escherichia coli mutT, and tentative definition of acatalytic domain of the dGTP pyrophosphohydrolasesMol. Microbiol. 11 (2), 323-330 (1994)PubMed: 8170394Bullions,L.C., Mejean,V., Claverys,J.P. and Bessman,M.J.Purification of the MutX protein of Streptococcus pneumoniae, ahomologue of Escherichia coli MutT. Identification of a novelcatalytic domain for nucleoside triphosphate pyrophosphohydrolaseactivityJ. Biol. Chem. 269 (16), 12339-12344 (1994)PubMed: 8163538","Mon Mar 11 14:20:16 2002","Mon Mar 11 14:20:16 2002","1","","","SMU.1455c","687" "MI0010","717","1472","756","atgctgggcatgtttcaggcagaaaggttaaaactgaagcgaagtatggcgaagaagttactagtttttgcccccataatagctattttatatggttttatagcacctgtggggtatttagtaaataatgcttataattggtggtatgtcatgatttttccagggctgctaaccttatttgctgctttaataaatacttacgaagaaaaaaagctgcattatcgagcagtgtttcctttgcccatttctttaagaaaattttggtttgaaaaaatttttataactgtttattatcttaattttagtaatggagtactttggataattacagtattactgaatacttttattttaccaaattatggaaaagactatacttatactgttggagaattagcactagcttctttggttataatagttactacactttggcaaattccattttgtctgtggctgacaaaaagaatcggttttaccataacgttgataattaatttaatgagtaatttcattttgggagttgtttttgcaactacttcctgctggtggctttgtccatatagttggggaatacgattaatggtacccattttaaaaatactaccgagtggtctaaaggcaggtatagcaggagctccatcattgccaacaagtttttggagtatcgttattagtttgtgtttagcggttatcttatttgttagtttgacagttttgagtgcatcttggtttgaaaaacaggaagtgaaatga","","","28663","MLGMFQAERLKLKRSMAKKLLVFAPIIAILYGFIAPVGYLVNNAYNWWYVMIFPGLLTLFAALINTYEEKKLHYRAVFPLPISLRKFWFEKIFITVYYLNFSNGVLWIITVLLNTFILPNYGKDYTYTVGELALASLVIIVTTLWQIPFCLWLTKRIGFTITLIINLMSNFILGVVFATTSCWWLCPYSWGIRLMVPILKILPSGLKAGIAGAPSLPTSFWSIVISLCLAVILFVSLTVLSASWFEKQEVK$","1472 mutE ABC transporter; may be involved with immunity","","MutE protein from strain CH43; ABC permease","Membrane, Cytoplasm","This sequence corresponds to GI:9802353 in GenBank. Nearest non-mutans neighbor is gi47568269 from B.cereus.","

noIPR
unintegrated

unintegrated
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[21-39]?$ $\"[45-65]?$ $\"[96-118]?$ $\"[132-152]?$ $\"[167-187]?$ $\"[223-245]?$	transmembrane_regions

","","","","","","","","","","","","","","","Thu May 5 20:30:18 2005","Thu May 5 20:32:16 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0598 and Smu0597 from the UA159 chromosome.","Thu May 5 20:32:16 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","","Thu May 5 20:30:18 2005","","5","","","","" "SMu1326","1387371","1387243","129","GTGGATAATTTTTATCTGATCCTTAAAATGGAAGAGCGAGGAAAATCGAAAAAGACTTCTCAGACAAGAGGCTTTAGGGCATTTTTTGATATAATAAGAAAAAAGATTAAAAAGGAAGATGGTAAATGA","11.00","6.98","5033","MDNFYLILKMEERGKSKKTSQTRGFRAFFDIIRKKIKKEDGK","1387258","","hypothetical protein","Periplasm, Extracellular","No hits in gapped BLAST found.SMu1326 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 14:47:37 2002","Mon Mar 11 14:47:37 2002","Mon Mar 11 14:47:37 2002","Mon Mar 11 14:47:37 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1326 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 14:47:37 2002","","No significant hits to the NCBI PDB database.","SMU.1456c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 14:47:37 2002","24379854","","","","","","1","","","SMU.1456c","" "SMu1327","1388587","1387541","1047","ATGACAGAATATAAAAACATTATCGTTACCGGTGGCGCTGGTTTCATCGGTTCAAACTTTGTCCACTACGTTTACAATAATCACCCAGATGTCCATGTGACTGTTCTTGACAAACTCACTTACGCTGGTAACCGTGCTAACCTTGAAGAAATTCTTGGCGACCGTGTAGAGTTGGTTGTTGGGGACATCGCAGACAGCGAATTGGTAGATAAATTGGCTGCCAAAGCGGATGCTATTGTCCACTATGCGGCTGAAAGCCACAATGACAATTCACTAAAAGATCCATCACCATTTATTTACACTAACTTTGTTGGAACTTATATCTTGTTGGAAGCTGCACGCAAATACGACATCCGTTTCCACCACGTCTCAACTGATGAAGTTTACGGTGATCTTCCGCTACGTGAAGATTTGCCGGGCCACGGTGAAGGTCCAGGTGAAAAATTCACAGCTGAAACGAAATACAATCCATCATCGCCTTATTCATCAACCAAGGCAGCCTCTGACTTGATTGTCAAGGCTTGGGTGCGATCTTTTGGTGTGAAAGCAACCATTTCCAACTGTTCAAACAACTATGGACCTTACCAACACATCGAAAAATTCATTCCGCGCCAAATTACTAACATCCTGTCAGGTATCAAACCAAAACTCTATGGTGAAGGTAAGAACGTGCGTGACTGGATTCACACCAATGACCATTCAACAGGAGTTTGGGCAATTCTCACTAAAGGCCGCATCGGCGAAACTTATCTCATCGGTGCTGATGGTGAAAAGAACAACAAAGAAGTGCTCGAACTTATCCTTGAAAAAATGAGTCAGCCAAAAAATGCATACGACCATGTAACAGACCGTGCAGGTCATGATCTTCGTTATGCCATTGATTCGACAAAGCTGCGTGAAGAGCTTGGCTGGAAACCACAATTCACTAATTTTGAAGAAGGCTTGGAAGATACCATTAAATGGTATACTGAGCATGAAGATTGGTGGAAAGCTGAAAAGGAAGCAGTCGAAGCCAACTATGCCAAAACACAAAAAATACTTAATTAA","5.80","-9.65","39268","MTEYKNIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNRANLEEILGDRVELVVGDIADSELVDKLAAKADAIVHYAAESHNDNSLKDPSPFIYTNFVGTYILLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSTGVWAILTKGRIGETYLIGADGEKNNKEVLELILEKMSQPKNAYDHVTDRAGHDLRYAIDSTKLREELGWKPQFTNFEEGLEDTIKWYTEHEDWWKAEKEAVEANYAKTQKILN","1387556","For other 'rml' genes see SMu0748 (rmlD); SMu1330 (rmlA) and SMu1329 (rmlC).","dTDP-glucose-4,6-dehydratase","Cytoplasm","Matches in gapped BLAST to dTDP-glucose-4,6-dehydratase:residues 9-348 are 99% similar to the previously published enzyme in S.mutans (gi|2494672|) Residues 4-347 are 93% similar to the protein in S.pyogenes(gi|15674955|).Residues 1-347 are 91% similar to the protein from S.pneumoniae (gi|3907612|) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1198 (0.0).","

InterPro
IPR001509
Family

NAD-dependent epimerase/dehydratase
PF01370	$\"[7-253]T$	Epimerase

InterPro
IPR005888
Family

dTDP-glucose 4,6-dehydratase
TIGR01181	$\"[6-332]T$	dTDP_gluc_dehyt

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-281]T$	G3DSA:3.40.50.720
PTHR10366	$\"[9-330]T$	PTHR10366
PTHR10366:SF41	$\"[9-330]T$	PTHR10366:SF41
SSF51735	$\"[5-342]T$	SSF51735

","BeTs to 7 clades of COG1088COG name: dTDP-D-glucose 4,6-dehydrataseFunctional Class: MThe phylogenetic pattern of COG1088 is a-tk---cEbrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB001509 (NAD dependent epimerase/dehydratase family) with a combined E-value of 1e-40. IPB001509A 7-28 IPB001509B 77-111 IPB001509C 189-195 IPB001509D 225-232 IPB001509E 295-305 IPB001509E 312-322","Residues 327-348 are identical to a (LYASE DTDP-GLUCOSE NAD 46-DEHYDRATASE) protein domain (PD069742) which is seen in RMLB_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 11:06:52 2002","Mon Mar 11 14:52:24 2002","Thu Oct 17 16:36:28 2002","Mon Mar 11 14:52:24 2002","Mon Mar 11 14:52:24 2002","Mon Mar 11 14:52:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1327 is paralogously related (blast p-value < 1e-3) to SMu0810, SMu1874 and SMu0346, all predicted UDP-glucose 4-epimerases; SMu0748,a predicted dTDP-4-keto-L-rhamnose reductase.","Mon Mar 11 14:55:51 2002","Mon Mar 11 14:52:24 2002","pdb|1BXK|B Chain B, Dtdp-Glucose 4,6-Dehydratase From E. Coli >... 295 6e-081pdb|1DB3|A Chain A, E.Coli Gdp-Mannose 4,6-Dehydratase 75 1e-014pdb|1KVS| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 72 9e-014","SMU.1457c","","Residues 3 to 326 (E-value = 1e-05) place SMu1327 in the 3Beta_HSD family which is described as 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073)Residues 7 to 326 (E-value = 2e-179) place SMu1327 in the Epimerase family which is described as NAD dependent epimerase/dehydratase family (PF01370)","Mon Mar 11 14:52:24 2002","","","Tsukioka,Y., Yamashita,Y., Oho,T., Nakano,Y. and Koga,T.Biological function of the dTDP-rhamnose synthesis pathway inStreptococcus mutansJ. Bacteriol. 179 (4), 1126-1134 (1997)PubMed: 9023194","","Mon Mar 11 14:52:24 2002","","1","","","SMU.1457c","134" "SMu1328","1389164","1388991","174","ATGGGTACTGTTGGTCTGGAAGATCGGACAGGCAGATTATGGCAGGCGCGTGTTGTAGATATTCATGTACCCAGTAACCCTCGTGGTTGGGAGGTGCCCGATGAGGAACAGATTTACCGAACGGTTGAGTTGACCGCCATGAGCATGAATTTTAGAAAAACGGTCTTTCTGTAG","5.80","-0.78","6616","MGTVGLEDRTGRLWQARVVDIHVPSNPRGWEVPDEEQIYRTVELTAMSMNFRKTVFL","1389006","","conserved hypothetical protein","Cytoplasm, Periplasm","A single significant match in gapped BLAST: residues 1-40 are 57% similar to residues 24-63 of gi|23024498, an hypotheticalprotein from Leuconostoc mesenteroides subsp. mesenteroidesATCC 8293.SMu1328 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 18:22:16 2002","Mon Oct 28 18:22:16 2002","Mon Oct 28 18:22:16 2002","Mon Mar 11 14:57:18 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1328 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Oct 28 18:22:16 2002","","No significant hits to the NCBI PDB database.","SMU.1459c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 14:57:18 2002","24379856","","","","","","1","","","SMU.1459c","" "SMu1329","1389688","1389227","462","ATGGTGCCGCTAGGTTTTCCAGAAAGCTTCTTTGCAGAAGGCAAATTGCAAAATAATGTTAGCTTTTCCCGTAAAAATGTTTTACGCGGTCTGCACGCAGAACCATGGGATAAATACATTTCAATAGCGGACGAGGGAAAGGTTCTCGGTTCTTGGATTGATCTGCGTGAAGGCGATAGTTTTGGTCATGTTTACCAAGCAGTTATTGATGCTTCCAAAGGTATCTTTGTTCCCCGCGGTGTGGCTAATGGTTTCCAAGTCTTATCTGACAAGGTTTCTTACAGTTATCTCGTTAATGACTACTGGGCGCTTGAACTCAAACCAAAATACGCTTTCGTCAACTATGCTGATCCAACATTAGGAATTGAATGGGAAAATTTGGAAGAAGCGCAAGTCTCAGAAGCGGATAAAAACCACCCATTGCTCAAAGATGTTAAACCATTAAAAGCAGAAGATTTGTGA","4.80","-6.28","17206","MVPLGFPESFFAEGKLQNNVSFSRKNVLRGLHAEPWDKYISIADEGKVLGSWIDLREGDSFGHVYQAVIDASKGIFVPRGVANGFQVLSDKVSYSYLVNDYWALELKPKYAFVNYADPTLGIEWENLEEAQVSEADKNHPLLKDVKPLKAEDL","1389242","For other 'rml' genes see SMu0748 (rmlD); SMu1330 (rmlA) and SMu1327 (rmlB).","dTDP-4-dehydrorhamnose 3,5-epimerase","Cytoplasm","Matches in gapped BLAST to dTDP-4-keto-L-rhamnose reductase : residues 1-153 are 98% similar to the previously published enzyme in S.mutans (gi1813346) Residues 1-153 are 90% similar to the protein in S.pneumoniae (gi13377431).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1199 (5e-79).","

InterPro
IPR000888
Family

dTDP-4-dehydrorhamnose 3,5-epimerase related
PD001462	$\"[1-151]T$	dTDP_sugar_isom
PF00908	$\"[1-145]T$	dTDP_sugar_isom

InterPro
IPR011051
Domain

Cupin, RmlC-type
SSF51182	$\"[1-153]T$	RmlC_like_cupin

InterPro
IPR014710
Domain

RmlC-like jelly roll fold
G3DSA:2.60.120.10	$\"[1-153]T$	RmlC-like_jellyroll

noIPR
unintegrated

unintegrated
PTHR21047	$\"[17-145]T$	PTHR21047

","BeTs to 5 clades of COG1898COG name: dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymesFunctional Class: MThe phylogenetic pattern of COG1898 is --Tk---Cebr----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-145 are 97% similar to a (35-EPIMERASE DTDP-4-DEHYDRORHAMNOSE) protein domain (PD001462) which is seen in P95779_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 31 16:47:07 2006","Mon Jul 31 16:46:43 2006","Mon Jul 31 16:46:43 2006","Mon Mar 11 15:01:36 2002","","Mon Mar 11 15:01:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1329 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 15:02:32 2002","","No significant hits to the NCBI PDB database.","SMU.1460c","","Residues 1 to 145 (E-value = 8.6e-12) place SMu1329 in the dTDP_sugar_isom family which is described as dTDP-4-dehydrorhamnose 3,5-epimerase (PF00908)","Mon Mar 11 15:01:36 2002","","","Tsukioka,Y., Yamashita,Y., Oho,T., Nakano,Y. and Koga,T.Biological function of the dTDP-rhamnose synthesis pathway inStreptococcus mutansJ. Bacteriol. 179 (4), 1126-1134 (1997)PubMed: 9023194","","Mon Mar 11 15:01:36 2002","","1","","","SMU.1460c","688" "SMu1330","1390694","1389825","870","ATGAAGGGAATTATTCTTGCGGGCGGCTCTGGGACGCGTTTATACCCATTGACTCGCGCTGCTTCAAAACAACTCATGCCGGTTTATGATAAACCAATGATTTATTATCCGCTTTCAACCTTGATGCTGGCAGGAATTAAAGATATTTTGATTATTTCCACGCCTCAAGATTTACCTCGTTTTAAAGAGTTGCTTCAGGATGGTTCCGAATTCGGCATTAAGCTCTCTTATGCTGAGCAACCGAGTCCAGATGGTTTGGCACAAGCCTTTATCATTGGAGAAGAATTTATCGGTGATGATCATGTTGCTCTCATTTTGGGAGATAATATTTATTACGGTCCGGGTCTTAGTCGAATGCTACAAAAAGCTGCCAGCAAAGAAAGCGGTGCAACTGTCTTTGGCTATCAAGTTAAAGATCCAGAACGCTTTGGCGTTGTTGAATTTGATAATGACAGAAATGCTATTTCCATTGAGGAAAAGCCAGAACACCCTAAATCACACTATGCAGTTACTGGTCTTTATTTTTACGACAATAGTGTTGTTGATATTGCTAAAAATATTAAACCTAGTCCTCGGGGAGAACTTGAAATTACAGATGTTAATAAAGCCTATCTTGACCGAGGAGACTTATCAGTTGAAGTTATGGAACGTGGTTTTGCTTGGCTAGATACAGGTACGCATGAAAGTCTACTAGAAGCTGCGCAATACATTGAAACCGTACAGCGTATGCAAAATTTACAAGTCGCTAATCTTGAAGAAATTGCTTATCGTATGGGCTATATCACAGCTGACCAAGTACGTGAATTGGCACAGCCTTTGAAGAAAAATGAATACGGGCAGTACTTGCTCCGTTTGATTGGAGAAGCTTAA","4.70","-11.01","32281","MKGIILAGGSGTRLYPLTRAASKQLMPVYDKPMIYYPLSTLMLAGIKDILIISTPQDLPRFKELLQDGSEFGIKLSYAEQPSPDGLAQAFIIGEEFIGDDHVALILGDNIYYGPGLSRMLQKAASKESGATVFGYQVKDPERFGVVEFDNDRNAISIEEKPEHPKSHYAVTGLYFYDNSVVDIAKNIKPSPRGELEITDVNKAYLDRGDLSVEVMERGFAWLDTGTHESLLEAAQYIETVQRMQNLQVANLEEIAYRMGYITADQVRELAQPLKKNEYGQYLLRLIGEA","1389840","For other 'rml' genes see SMu0748 (rmlD); SMu1327 (rmlB) and SMu1329 (rmlC).","glucose-1-phosphate thymidyltransferase","Cytoplasm","This sequence corresponds to the previously published gi2500162 in Genbank, a predicted glucose-1-phosphate thymidyltransferase. Residues 1-289 are 100% similar to the enzyme from S.mutans.Residues 1-289 are 90% similar to the enzyme from S.pneumoniae (gi13377430)The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1200 (1e-151).","

InterPro
IPR005835
Domain

Nucleotidyl transferase
PF00483	$\"[2-240]T$	NTP_transferase

InterPro
IPR005907
Family

Glucose-1-phosphate thymidylyltransferase, long form
TIGR01207	$\"[2-287]T$	rmlA

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[2-288]T$	G3DSA:3.90.550.10
PTHR22572	$\"[9-286]T$	PTHR22572
PTHR22572:SF13	$\"[9-286]T$	PTHR22572:SF13
SSF53448	$\"[1-288]T$	SSF53448

","BeTs to 8 clades of COG1209COG name: dTDP-glucose pyrophosphorylaseFunctional Class: MThe phylogenetic pattern of COG1209 is a-tk--vcEbr----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 25-108 are identical to a (TRANSFERASE GLUCOSE-1-PHOSPHATE) protein domain (PD307342) which is seen in RMLA_STRMU.Residues 239-286 are identical to a (TRANSFERASE GLUCOSE-1-PHOSPHATE) protein domain (PD002767) which is seen in RMLA_STRMU.Residues 109-142 are 64% similar to a (TRANSFERASE GLUCOSE-1-PHOSPHATE) protein domain (PD415991) which is seen in Q9ZFP0_KLEPN.Residues 1-24 are identical to a (TRANSFERASE GLUCOSE-1-PHOSPHATE) protein domain (PD396830) which is seen in Q9RQH0_STRPN.Residues 2-142 are 70% similar to a (TRANSFERASE COMPLETE PROTEOME BIOSYNTHESIS) protein domain (PD000318) which is seen in Q9RZB2_DEIRA.Residues 1-51 are 52% similar to a (FACTOR INITIATION TRANSLATION EIF-2B) protein domain (PD412714) which is seen in Q9N5Y4_CAEEL.Residues 143-238 are identical to a (TRANSFERASE GLUCOSE-1-PHOSPHATE) protein domain (PD000406) which is seen in RMLA_STRMU.Residues 143-233 are 32% similar to a (TRANSFERASE PYROPHOSPHORYLASE ADP-GLUCOSE) protein domain (PD001252) which is seen in Q9UXD3_SULSO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 13 14:00:47 2006","Mon Mar 11 15:04:36 2002","Wed Sep 13 13:59:54 2006","Mon Mar 11 15:04:36 2002","","Wed Jan 16 11:40:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1330 is paralogously related (blast p-value < 1e-3) to SMu1399, a predicted glucose-1-phosphate adenylyltransferase ; SMu0289, a predicted glucose-1-phosphate uridylyltransferase;and SMu1488, a predicted UDP-N-acetylglucosamine pyrophosphorylase.","Mon Mar 11 15:09:00 2002","Wed Sep 13 13:59:54 2006","pdb1FXOA Chain A, The Structural Basis Of The Catalytic Mecha... 409 3e-115pdb1G23A Chain A, The Structural Basis Of The Catalytic Mecha... 402 4e-113","SMU.1461c","","Residues 2 to 240 (E-value = 7.5e-120) place SMu1330 in the NTP_transferase family which is described as Nucleotidyl transferase (PF00483)","Wed Jan 16 11:40:57 2002","","","Tsukioka,Y., Yamashita,Y., Oho,T., Nakano,Y. and Koga,T.Biological function of the dTDP-rhamnose synthesis pathway inStreptococcus mutansJ. Bacteriol. 179 (4), 1126-1134 (1997)PubMed: 9023194","","Mon Mar 11 15:04:36 2002","","1","","","SMU.1461c","394" "SMu1331","1391862","1390759","1104","ATGAAAAAAGTTGCTATTATTGGAGCAGGTATCGTAGGTGCAACAGCTGCTTATTACTTATCTAAAGAAAAAGATATTGCTGTAACGGTCTTTGATGACGGATTCGGACAGGCAACGAAAGCGGCAGCGGGCATCATTTGCCCTTGGTTTTCCAAACGCCGTCATAAAGCATGGTATCGTTTGGCGCGTTTGGGAGCAGATTTTTATCAAACCTTGCTTTCCGATTTAAAAAGGGATGCTTGTAAGGTTGACTTTTATGAACAATCTGGTGCTTTTCTCTTAAAAAATAAAGCAGAAAGCTTAGATGAGCTTTTTGAGATAGGTCAAAAACGCAAAAGTCAGTCTCCTCTCATCGGCCATTTAGAAATTCAAAAACGAGCAGACCTTACAGGTCTATTAGCAGATCTTGTCGGTTTTGATAGGTGTATTTATGCTTCTGGTGCTGCTCGTGTTGAAGGTGCCAGTTTAACAGAAGCACTTTTAAACGCCAGTCATGCGAAAATGGTTAACAAGAAAGTAGGACTTCAAGTGTTATCAGATGGTAACTATAGGGTTAATGGCAAAAAATATACAGCAGTATTACTTGCTTGCGGTGCTTGGTTACCGCAAATATTAGAACCACTCGGTTATAAGATTGACATTAGGCCACAAAAAGGGCAATTACGTGATTACTTTTTTAATAGCGAAGATACAGAGAAATTTCCAGTTATTATGCCTGAGGGTGAAGTTGATATCATTCCTTTTGCTCATGGAAAAGTGAGTGTTGGGGCCAGTCATGAAAATGATCACGGGTTTGATCTGCAAATCGATAACAGTGTTTTGGATAAAATGGAGAAGGAAGCGCAAACTTATTTTCCAAAATTAAAAGAGGCCACTTCAAAAAATGAGCGAGTAGGAACACGAGCCTATACCCGTGATTTTGCCCCTTTCTTTGGCCGAGTAACTGGCTTAGCCAATGTTTATGCAGCCAGCGGTCTAGGATCCTCTGGTTTAACAACAGGTCCTTTGATTGGCAATCAACTAGTAAAGATGCTCTTGGATAAAGAATTAGACATACAGGCCAGTGATTACAGTCCTGATAAATATATCGTTAAGAATAGCTAG","8.80","5.27","40367","MKKVAIIGAGIVGATAAYYLSKEKDIAVTVFDDGFGQATKAAAGIICPWFSKRRHKAWYRLARLGADFYQTLLSDLKRDACKVDFYEQSGAFLLKNKAESLDELFEIGQKRKSQSPLIGHLEIQKRADLTGLLADLVGFDRCIYASGAARVEGASLTEALLNASHAKMVNKKVGLQVLSDGNYRVNGKKYTAVLLACGAWLPQILEPLGYKIDIRPQKGQLRDYFFNSEDTEKFPVIMPEGEVDIIPFAHGKVSVGASHENDHGFDLQIDNSVLDKMEKEAQTYFPKLKEATSKNERVGTRAYTRDFAPFFGRVTGLANVYAASGLGSSGLTTGPLIGNQLVKMLLDKELDIQASDYSPDKYIVKNS","1390774","","oxidoreductase, DadA family protein/D-amino acid oxidase","Cytoplasm","Limited significant matches in gapped BLAST to conserved hypothetical and to oxidoreductase: residues 1-363 are 52% similar to conserved hypothetical protein from S.pneumoniae (gi15903504). Residues 18-367 are 53% similar to oxidoreductase from S.pyogenes (gi15674952). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1201 (1e-108).","

InterPro
IPR006076
Family

FAD dependent oxidoreductase
PF01266	$\"[3-344]T$	DAO

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[3-353]T$	G3DSA:3.50.50.60
PTHR13847	$\"[3-362]T$	PTHR13847
PTHR13847:SF13	$\"[3-362]T$	PTHR13847:SF13
SSF51971	$\"[2-349]T$	SSF51971
SSF54373	$\"[214-304]T$	SSF54373

","BeTs to 4 clades of COG0665COG name: Predicted oxidoreductasesFunctional Class: RThe phylogenetic pattern of COG0665 is amtKyq-CEBRhuj--o-in-Number of proteins in this genome belonging to this COG is 1","***** IPB000927 (D-amino acid oxidase) with a combined E-value of 1.3e-06. IPB000927A 3-15 IPB000927B 34-77 IPB000927D 254-288 IPB000927E 320-344***** IPB000103 (Pyridine nucleotide-disulphide oxidoreductase class-II) with a combined E-value of 2.7e-06. IPB000103A 3-23 IPB000103E 315-352","Residues 19-217 are 31% similar to a (PROTEOME COMPLETE YTEB) protein domain (PD400242) which is seen in Q9CEG8_LACLA.Residues 235-359 are 32% similar to a (OXIDOREDUCTASE PROTEOME COMPLETE OXIDASE SARCOSINE) protein domain (PD001376) which is seen in YURR_BACSU.Residues 18-72 are 53% similar to a (OXIDOREDUCTASE OXIDASE PROTEOME COMPLETE) protein domain (PD209125) which is seen in YURR_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:34:10 2002","Wed Sep 13 15:43:21 2006","Wed Sep 13 15:43:21 2006","Mon Mar 11 15:16:42 2002","Mon Mar 11 15:16:42 2002","Mon Mar 11 15:16:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1331 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 16:34:10 2002","","No significant hits to the NCBI PDB database.","SMU.1462c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 15:16:42 2002","24379859","","","","","","1","","","SMU.1462c","395" "SMu1332","1392677","1391889","789","ATGAAAGCTAGTCAAATCATTAAACGTTACGAAACTTATTGTCCGCAGGACTTGTCTTTGGAAGGCGATATATCGGGTCTGCAAATTGGGACACTGGATAAGGAAATCAAGCGGCTTATGATTGCTCTGGATGTTCGGGAAACAACTGTAGCCGAAGCGATTGAAAAAAAGGTAGATTTATTGATTGTCAAGCATGCTCCTATCTTTCGTCCTTTGAAGAATTTAGTTGAGACTGCTCAAAATCATATTTATTTTAATCTCATTAAGCATGATATTGCTGTTTATGTCAGCCATACAAATATTGATATTGTTCCTGATGGGCTCAATGATTGGTTTTGTGATTTATTGGATATCAAGAACAGAAGAATTTTGAGTCCAAGTAAAGATGATTATGGTATTGGGCGTGTTGGAGATATTTCTCCCCTCTCTTTTGAAGATTTGGCAAAAAAGGTTAAGAAAATTTTTAATTTGGATAGCGTTCGTTTGGTGTCTTATGGTGAGAATAATCCTTTAATTTCTCGTGTTGCCATTTGTGGCGGCAGTGGTCAGAGTTTTTATCAAGAAGCTCTAACTAAAGGAGCTCAAGTTTATATCACAGGTGATATTTATTACCATACCGCTCAGGAAATGTTAACCAATGGTCTCTTGGCTTTGGATCCCGGCCATCATATTGAAGTCTTATTTGTTAGGGAATTGGCTGAAAAATTCCAAACATGGTCCTGTCAAGAAAACTGGGACATCACTATTTTAGAAAGTCAAGTTAACACCAATCCGTTTTATCATTTATGA","5.60","-6.26","29726","MKASQIIKRYETYCPQDLSLEGDISGLQIGTLDKEIKRLMIALDVRETTVAEAIEKKVDLLIVKHAPIFRPLKNLVETAQNHIYFNLIKHDIAVYVSHTNIDIVPDGLNDWFCDLLDIKNRRILSPSKDDYGIGRVGDISPLSFEDLAKKVKKIFNLDSVRLVSYGENNPLISRVAICGGSGQSFYQEALTKGAQVYITGDIYYHTAQEMLTNGLLALDPGHHIEVLFVRELAEKFQTWSCQENWDITILESQVNTNPFYHL","1391904","","conserved hypothetical protein, NIF3-related","Cytoplasm","Matches in gapped BLAST to previously published sequence from S.mutans:residues 1-262 are 98% similar to ORF4 (gi1813344)Residues 1-262 are 62% similar to conserved hypothetical protein from S.pyogenes (gi15674951). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1202 (1e-112).","

InterPro
IPR002678
Family

NGG1p interacting factor 3, NIF3
PTHR13799	$\"[1-234]T$	interacting_NIF3
PF01784	$\"[10-247]T$	NIF3
TIGR00486	$\"[1-258]T$	interacting_NIF3

noIPR
unintegrated

unintegrated
SSF102705	$\"[1-258]T$	SSF102705

","BeTs to 12 clades of COG0327COG name: Uncharacterized ACR, YbgI/Acr familyFunctional Class: SThe phylogenetic pattern of COG0327 is amtky---ebrhuj--olin-Number of proteins in this genome belonging to this COG is 1","***** IPB002678 (Domain of unknown function DUF34) with a combined E-value of 1.5e-41. IPB002678A 21-31 IPB002678B 53-65 IPB002678C 87-110 IPB002678D 172-182 IPB002678E 194-226","Residues 226-262 are 97% similar to a (ORF4) protein domain (PD372413) which is seen in P95777_STRMU.Residues 132-225 are 98% similar to a (PROTEOME COMPLETE RPOD YKID) protein domain (PD113609) which is seen in P95777_STRMU.Residues 130-209 are 34% similar to a (PROTEOME COMPLETE NGG1-INTERACTING FACTOR) protein domain (PD352957) which is seen in O69481_MYCLE.Residues 2-120 are 99% similar to a (COMPLETE PROTEOME NGG1-INTERACTING FACTOR) protein domain (PD037766) which is seen in P95777_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 17:25:54 2002","Wed Sep 13 15:48:03 2006","Wed Sep 13 15:48:03 2006","Mon Mar 11 15:19:34 2002","Mon Mar 11 15:19:34 2002","Mon Mar 11 15:19:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1332 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 17:25:54 2002","","No significant hits to the NCBI PDB database.","SMU.1463c","","Residues 10 to 247 (E-value = 3.1e-105) place SMu1332 in the NIF3 family which is described as NIF3 (NGG1p interacting factor 3) (PF01784)","Mon Mar 11 15:19:34 2002","24379860","","Tsukioka,Y., Yamashita,Y., Oho,T., Nakano,Y. and Koga,T.Biological function of the dTDP-rhamnose synthesis pathway inStreptococcus mutansJ. Bacteriol. 179 (4), 1126-1134 (1997)PubMed: 9023194","","Mon Mar 11 17:30:24 2002","","1","","","SMU.1463c","396" "SMu1333","1393365","1392667","699","ATGCCAGATAAGAAGAGAGAAGTTTCCCTTTCTCATCGTTTACAGGAAGTAGCAAGCTTTGTGCCAAAAGGTGCAAGGCTTCTTGATGTTGGCAGTGATCATGCTTATTTGCCCATTTACTTACTTGAGCAAGGGCTGATTGACTTTGCTGTTGCTGGTGAAATTATCAAGGGTCCCTATGAATCTGCTGTGGCTAATGTCAGTGAATCAGAATTGTCAGGCCAAATTGCTGTTCGTTTAGCTGATGGTTTGGCGGCTCTTAATGATAATGATGATATTGATCTTATTACCATTTGTGGCATGGGCGGTCGTTTGATTGCCGATATATTAGCAGCTGGTAGTGATAAATTAAATTCTGTTAAACAATTAATTTTACAGCCTAATAATTGTGAAGATGACTTACGTTCTTGGCTAGTAGCCAATGATTTTATGATTAAGGCTGAAAAAATGGTAAAGGATAGACACAAGTATTATGAAATCTTAGTGGTTGAAAAAGGAAAGATAACTTTGTCAGATAAAGACTTGCGCTTTGGGCCATTTTTGCGACAAGAACGGTCGTCTATCTTTAAAGAAAGATGGCGGAAAGAATTGGCTAAATTGGAATTGGCTCTGACCAAGGTTCCTGCTAAAAAGAAAGCAGACAACATGTTCCTTAGCACAAAAATCGAGCAAATTAAGGAGGTGCTCTATGAAAGCTAG","6.30","-1.36","26004","MPDKKREVSLSHRLQEVASFVPKGARLLDVGSDHAYLPIYLLEQGLIDFAVAGEIIKGPYESAVANVSESELSGQIAVRLADGLAALNDNDDIDLITICGMGGRLIADILAAGSDKLNSVKQLILQPNNCEDDLRSWLVANDFMIKAEKMVKDRHKYYEILVVEKGKITLSDKDLRFGPFLRQERSSIFKERWRKELAKLELALTKVPAKKKADNMFLSTKIEQIKEVLYES","1392682","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to previously published sequence from S.mutans:residues 1-232 are 86% similar to ORF3 (gi|1813343|) Residues 10-229 are 51% similar to conserved hypothetical protein from S.pyogenes (gi|15674950|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1203 (8e-64).","

InterPro
IPR006901
Family

Protein of unknown function DUF633
PF04816	$\"[27-227]T$	DUF633

noIPR
unintegrated

unintegrated
SSF53335	$\"[10-157]T$	SSF53335

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 182-232 are 76% similar to a (ORF3) protein domain (PD111712) which is seen in P95776_STRMU.Residues 10-181 are 88% similar to a (PROTEOME COMPLETE MG248 H91_ORF213) protein domain (PD013607) which is seen in P95776_STRMU.Residues 29-192 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD275286) which is seen in Q9RXN4_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 12 08:32:22 2002","Thu May 2 11:37:10 2002","Tue Mar 12 08:30:45 2002","Tue Mar 12 08:30:45 2002","","Tue Mar 12 08:30:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1333 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 12 08:32:22 2002","","No significant hits to the NCBI PDB database.","SMU.1464c","","Residues 27 to 227 (E-value = 6.8e-119) place SMu1333 in the DUF633 family which is described as Family of unknown function (DUF633) (PF04816)","Tue Mar 12 08:30:45 2002","24379861","","Tsukioka,Y., Yamashita,Y., Oho,T., Nakano,Y. and Koga,T.Biological function of the dTDP-rhamnose synthesis pathway inStreptococcus mutansBacteriol. 179 (4), 1126-1134 (1997)PubMed: 9023194","","Tue Mar 12 08:32:22 2002","","1","","","SMU.1464c","689" "SMu1334","1394050","1393355","696","ATGAGTTTTTTGCAACATTATAAATCAGGGAATTTGGTCTTACCAAGTGCCTTGCTTTTTCATTACAAAGATATTTTTAGTAATGCGGATGATTTTCTGGTTTGGCAATTTTTCTACTTTCAAAACACCACAAAGATGGAAGACATTGCTACGAGTCAGATAGCCACAGCTATTGGCAAGACTGTCCCAGAAGTTAATCGCTCAGTGTCCAATCTGATTAGTCAAGAGTTGCTAGACATGAAGACGATTGAATTGGACGGAGAAAGCGAAGTTCTATTTGATGCTACTTTGGCATTGAAAAAACTGGATGATTTGTTAACTGCAGCTGATGAGACAACTGTCTCATCTTCTAAAGGTATAAGTAATGCCTTGAAGGATTTGGTTGAAGATTTTGAGCGTGAATTAGGACGTATGCTGAGTCCTTTTGAGTTAGAAGATCTGCAAAAGACGGTTTCAGATGATAAGACAGATCCTGATCTTGTTCGATCAGCCTTACGTGAAGCTGTTTTTAATGGCAAGACCAATTGGAATTATATTCAAGCCATCTTGCGAAATTGGCGTCATGAAGGGATTAGTACATTACGCCAAGTTGAAGAAAGACGCAAGGAGCGAGAACAAGCCAATCCAGCCAATGTAACCGTTTCAGACGATTTTTTGTCTGCTATGAATTTATGGAGTGATTCTGATGCCAGATAA","4.50","-13.26","26279","MSFLQHYKSGNLVLPSALLFHYKDIFSNADDFLVWQFFYFQNTTKMEDIATSQIATAIGKTVPEVNRSVSNLISQELLDMKTIELDGESEVLFDATLALKKLDDLLTAADETTVSSSKGISNALKDLVEDFERELGRMLSPFELEDLQKTVSDDKTDPDLVRSALREAVFNGKTNWNYIQAILRNWRHEGISTLRQVEERRKEREQANPANVTVSDDFLSAMNLWSDSDAR","1393370","","DNA replication protein DnaD","Cytoplasm","Matches in gapped BLAST to previously published sequence from S.mutans:residues 1-231 are 85% similar to ORF2 (gi1813342) Residues 1-228 are 59% similar to conserved hypothetical protein from S.pyogenes (gi15674948). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1204 (2e-71).","

InterPro
IPR006343
Domain

DnaD and phage-associated region
PF04271	$\"[127-199]T$	DnaD
TIGR01446	$\"[127-199]T$	DnaD_dom

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 118-229 are 87% similar to a (DNA REPLICATION PROTEOME COMPLETE) protein domain (PD021297) which is seen in P95775_STRMU.Residues 1-93 are identical to a (PROTEOME COMPLETE ORF2 DNA) protein domain (PD083566) which is seen in P95775_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 12 08:37:29 2002","Wed Jul 12 15:08:49 2006","Wed Jul 12 15:08:49 2006","Tue Mar 12 08:35:03 2002","","Tue Mar 12 08:35:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1334 is paralogously related (blast p-value < 1e-3) to SMu1437, a predicted DNA polymerase III subunits gamma / tau.","Tue Mar 12 08:35:03 2002","","No significant hits to the NCBI PDB database.","SMU.1465c","","Residues 127 to 199 (E-value = 1.7e-40) place SMu1334 in the DnaD family which is described as DnaD-like domain (PF04271)","Tue Mar 12 08:35:03 2002","24379862","","Tsukioka,Y., Yamashita,Y., Oho,T., Nakano,Y. and Koga,T. Biological function of the dTDP-rhamnose synthesis pathway in Streptococcus mutans J. Bacteriol. 179 (4), 1126-1134 (1997) PubMed: 9023194 ","","Tue Mar 12 08:37:29 2002","","1","","","SMU.1465c","816" "SMu1335","1395004","1394060","945","ATGCCAATTACTCTTGATAAAAAATTACCAGCTGTGGATATTTTGAAGTCGGAAAATATCTTCGTTATGGATGATAAAAGGGCAATTCATCAGGATATTCGGCCCATGAGTATCTTGATTCTTAATTTAATGCCAACAAAGGTAGCAACAGAAACGCAATTACTGCGCCTGTTGGCTAATACGCCCTTGCAGCTGAGTGTTGACTTTCTCTACATGACGAGTCATCATTCAAAAACCACTCAGGCTGAACATATGAAGACCTTTTATAAAACTTTTAAGGATATCAAAGACAATTATTATGATGGCTTGATTATCACAGGTGCACCAGTTGAGACCATGCCCTTTGAGAAAGTTGATTATTGGGAGGAACTCTGTCAGGTTTTTCAATGGTCTAAGACTCATGTTTACTCTACTTTGCATCTTTGTTGGGGAGCACAAGCAGGGTTATATTATCGTTATAGTGTTGATAAGGTTCAGATGACAGATAAATTATCAGGCATTTATTTGCAGAAAGTAAATGAACAGCTAAGTCCTTTGATGCGTGGTTTTGATGATTGTTTCCTTTCACCTCATTCGCGCTACACTGAAGTATTGCTAAAAGACATTAACAACAAAACCAATCTAGAAATCCTTGCTAGCGGTGAAAAAGTTGGTCTGTCTATTTTGGCCAGTCGTGATATGCGAGAGGTTTACAGTTTTGGTCATTTAGAATATGACCGAGAAACCTTGGACAATGAATACAAACGCGATCTCAAAGCTGGTAAGAGTCCTAAAATTCCGGAAAATTATTATCAAGATGATGATGTGACAACTCATCCTATTATGCGTTGGAATCTCGCAGCAGCGACTTTTTTTAGCAATTGGATTAATTACGCTGTTTATCAAGAAACCCCTTATCGCTTGGAAGAGTTGGAAAAGGATATATCATTTTATGGCTATCTGTAA","5.90","-5.96","36720","MPITLDKKLPAVDILKSENIFVMDDKRAIHQDIRPMSILILNLMPTKVATETQLLRLLANTPLQLSVDFLYMTSHHSKTTQAEHMKTFYKTFKDIKDNYYDGLIITGAPVETMPFEKVDYWEELCQVFQWSKTHVYSTLHLCWGAQAGLYYRYSVDKVQMTDKLSGIYLQKVNEQLSPLMRGFDDCFLSPHSRYTEVLLKDINNKTNLEILASGEKVGLSILASRDMREVYSFGHLEYDRETLDNEYKRDLKAGKSPKIPENYYQDDDVTTHPIMRWNLAAATFFSNWINYAVYQETPYRLEELEKDISFYGYL","1394075","For other 'met' genes see SMu0796 (metE),(metC);SMu1527 (metB); SMu1492 (metS) and SMu1430 (metK).","homoserine O-succinyltransferase","Cytoplasm","Several matches in gapped BLAST to homoserine O-succinyltransferase: residues 1-314 are 67% similar to the enzyme in S.pneumoniae (gi|15903477|). Residues 1-313 are 53% similar to the protein from Lactococcus lactis (gi|15673900|).SMu1335 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005697
Family

Homoserine O-succinyltransferase
PD037892	$\"[23-301]T$	Homser_suc_trans
PIRSF000450	$\"[1-307]T$	H_ser_succinyltr
PTHR20919	$\"[2-300]T$	Homser_suc_trans
PF04204	$\"[2-299]T$	HTS
TIGR01001	$\"[1-302]T$	metA

noIPR
unintegrated

unintegrated
SSF52317	$\"[31-238]T$	SSF52317

","BeTs to 3 clades of COG1897COG name: Homoserine trans-succinylaseFunctional Class: EThe phylogenetic pattern of COG1897 is ------v-eb-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-299 are 55% similar to a (HOMOSERINE O-SUCCINYLTRANSFERASE HTS) protein domain (PD037892) which is seen in Q9CEC5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:33:39 2002","Tue Mar 12 08:39:09 2002","Thu Oct 17 16:33:39 2002","Tue Mar 12 08:39:09 2002","","Tue Mar 12 08:39:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1335 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 12 08:41:29 2002","","No significant hits to the NCBI PDB database.","SMU.1466c","","Residues 1 to 301 (E-value = 3e-209) place SMu1335 in the HTS family which is described as Homoserine O-succinyltransferase (PF04204)","Tue Mar 12 08:39:09 2002","","","","Duclos,B., Cortay,J.C., Bleicher,F., Ron,E.Z., Richaud,C., SaintGirons,I. and Cozzone,A.J.Nucleotide sequence of the metA gene encoding homoserinetrans-succinylase in Escherichia coliNucleic Acids Res. 17 (7), 2856 (1989)PubMed: 2654885Michaeli,S., Mevarech,M. and Ron,E.Z.Regulatory region of the metA gene of Escherichia coli K-12J. Bacteriol. 160 (3), 1158-1162 (1984)PubMed: 6094503","","Tue Mar 12 08:44:47 2002","1","","","SMU.1466c","" "SMu1336","1395626","1395108","519","ATGGATTTAAAAAATTACATTGCAACAATTGAGGATTATCCACAAGAAGGCGTCACTTTTCGTGATATCAGTCCTTTGATGGCTAACGGCAATGCTTATAGCTATGCTATTCGTGAGATTGTCCAATATGCGACAGATAAAAAAATTGACATGATTGTTGGACCTGAAGCGCGTGGTTTTATTGTTGGCTGTCCGGTCGCCTATGAATTGGGTGTTGGCTTTGCTCCTGTCCGCAAACCGGGGAAACTGCCGCGTGAAGTTATTGAAGCTCATTATGAAAAAGAATATGGTATTGATACCTTAACCATGCATGCAGATGCCATTAAGCCCGGTCAAAGGGTTCTTATTGTTGACGATCTTTTAGCAACTGGTGGCACAGTTAAGGCAACCATTGAAATGATTGAAAGGTTAGGCGGTATTGTTGCAGGCTGTGCTTTCTTAATCGAGTTAGATGGGCTCGATGGACGTCAGGCTATTGAAGGTTATGATACTAAAGTTTTGATGAATTTCCCTGGCTAA","4.60","-7.61","18769","MDLKNYIATIEDYPQEGVTFRDISPLMANGNAYSYAIREIVQYATDKKIDMIVGPEARGFIVGCPVAYELGVGFAPVRKPGKLPREVIEAHYEKEYGIDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIERLGGIVAGCAFLIELDGLDGRQAIEGYDTKVLMNFPG","1395123","","adenine phosphoribosyltransferase","Cytoplasm","Several matches in gapped BLAST to adenine phosphoribosyltransferase: residues 1-170 are 84% similar to the enzyme in S.pneumoniae (gi|15903478|). Residues 1-172 are 83% similar to the protein from S.pyogenes (gi|15674947|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1205 (8e-89).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[22-158]T$	Pribosyltran

InterPro
IPR002375
Family

Purine/pyrimidine phosphoribosyl transferase
PS00103	$\"[114-126]T$	PUR_PYR_PR_TRANSFER

InterPro
IPR005764
Family

Adenine phosphoribosyl transferase
TIGR01090	$\"[3-170]T$	apt

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2020	$\"[3-167]T$	G3DSA:3.40.50.2020
SSF53271	$\"[1-167]T$	SSF53271

","BeTs to 13 clades of COG0503COG name: Adenine/guanine phosphoribosyltransferasesFunctional Class: FThe phylogenetic pattern of COG0503 is -mtkY-vcEBrHujgpol---Number of proteins in this genome belonging to this COG is 2","***** IPB002375 (Purine/pyrimidine phosphoribosyl transferase) with a combined E-value of 5e-10. IPB002375A 78-82 IPB002375B 111-126","Residues 56-113 are 87% similar to a (TRANSFERASE ADENINE GLYCOSYLTRANSFERASE) protein domain (PD001933) which is seen in APT_LACLA.Residues 114-167 are 74% similar to a (TRANSFERASE ADENINE GLYCOSYLTRANSFERASE) protein domain (PD267958) which is seen in APT_LACLA.Residues 12-54 are 76% similar to a (TRANSFERASE ADENINE GLYCOSYLTRANSFERASE) protein domain (PD028734) which is seen in APT_LACLA.Residues 114-159 are 63% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD343576) which is seen in APT_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 12 08:52:27 2002","Tue Mar 12 08:51:10 2002","Thu Oct 17 16:33:10 2002","Tue Mar 12 08:51:10 2002","Tue Mar 12 08:51:10 2002","Tue Mar 12 08:51:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1336 is paralogously related (blast p-value < 1e-3) to SMu0321, a predicted purine operon repressor and SMu1116, a predicted orotate phosphoribosyltransferase.","Tue Mar 12 08:52:27 2002","Tue Mar 12 08:51:10 2002","pdb|1QB7|A Chain A, Crystal Structures Of Adenine Phosphoribosy... 63 2e-011","SMU.1467c","","Residues 22 to 158 (E-value = 1.9e-47) place SMu1336 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Tue Mar 12 08:51:10 2002","","","","Hershey,H.V. and Taylor,M.W.Nucleotide sequence and deduced amino acid sequence of Escherichiacoli adenine phosphoribosyltransferase and comparison with otheranalogous enzymesGene 43 (3), 287-293 (1986)PubMed: 3527873","","Tue Mar 12 08:51:10 2002","1","","","SMU.1467c","574" "SMu1337","1396931","1396299","633","ATGAAACATGAATGGCGTAAATTTGAAAAAGAGTTATACGGTGTCAAAGCAAAACCCATTTTTCTTGAAGTAGAAGAACAACGGTTTATTACCATCAAAGGAAAAGGAAACCCTAATGATCAAGATTTCTCTAATCGAGTATCTGCTCTTTATGCTTTAGCTTATGGCATTAAAATGGCTTATAAACAAGCAATGAAGACTGAGCAGGATGATCGGGCAGTTACTGATTTTGCAGTCTATCCTTTGGAAGGTCTCTGGCAGCAAGCGAAAGATGCTAAGGAGGATACTTTGGAAAAAGATAAACTCTCCTATACGATTATGATTCGTCAGCCTGAATTTATCACTAAAGAACTTGTTGACCAAGCTTTAGATAGGGTCAAGATCAAAAAACCAAATTCTTTTTACGAATCTATTTCTTTTGAAAGTATTAAAGATGGAAAATGTATTCAGGTTCTTCATATCGGATCTTATGATGATGAACCGCAGTCTTTTGCTAAGATGGACGCTTTTGCCAAAGAACATGGTTTAAAACGTTCGTCTGACATTCACAGGGAAATCTACCTCAGCAATGCGCAGAGAACAGAAAAAAGCAAGCTCAAAACTATTTTACGCTATCAAGTGGAGGAAAAATGA","9.00","2.93","24559","MKHEWRKFEKELYGVKAKPIFLEVEEQRFITIKGKGNPNDQDFSNRVSALYALAYGIKMAYKQAMKTEQDDRAVTDFAVYPLEGLWQQAKDAKEDTLEKDKLSYTIMIRQPEFITKELVDQALDRVKIKKPNSFYESISFESIKDGKCIQVLHIGSYDDEPQSFAKMDAFAKEHGLKRSSDIHREIYLSNAQRTEKSKLKTILRYQVEEK","1396314","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to unknowns: residues 2-208 are 37% similar to an unknown protein from Lactococcus lactis (gi|15672215|) residues 2-207 are 33% similar to an unknown protein from Listeria innocua (gi|16801254|) . SMu1337 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR008319
Family

Uncharacterised conserved protein UCP031644
PIRSF031644	$\"[1-210]T$	UCP031644

InterPro
IPR011256
Domain

Bacterial regulatory factor, effector
SSF55136	$\"[135-208]T$	Bac_reg_effector

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-208 are 37% similar to a (PROTEOME COMPLETE) protein domain (PD400417) which is seen in Q9CIX3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 22 09:04:02 2002","Tue Mar 12 08:55:02 2002","Fri Mar 22 09:04:02 2002","Tue Mar 12 08:55:02 2002","","Tue Mar 12 08:55:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1337 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 22 09:04:02 2002","","No significant hits to the NCBI PDB database.","SMU.1470c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 08:55:02 2002","24379865","","","","","","1","","","SMU.1470c","" "SMu1338","1398083","1397184","900","ATGAGAGAGAGCAGATTATTTCAAATCATTTATCAGTTATTGACAAAGAAAAAGGTCACAGCAGCTAATTTAGCTAAACAGTTTGAAGTTTCTGTCAGAACGATTTATCGTGATATTGATGCTCTTAGCAGCAGCGGTATTCCTATCTATGCCAGTCAAGGGAAAAATGGCGGTATTCAGCTGGATGAGGATTTTGTTTTGTCTAAGTCCTTATTGTCACAAGAAGAAAAAGAACAGATTTTAGATGGCCTGCAAGGTTTAGGTTCCGTTAACGGTATTGTAAACGATAAACAGTTACTGACTAAATTGTCAGCTTTGTTCAAAGTGAAAAATCCTAATTGGATTGAGGTCCAGTTTAGTCCTTGGCAAAATCATGATCAGCAGCAGAAATTAGTTCAGCTTATAAAAGAAGCTATTTGTCAGAAGCACTTTTTTTCCTTCCTTTATTTCAGTAGTCTAGCCAAACAAACCAAGCGGAAGGTCAAACCTGTTCGTCTTGTTTTTAAAGGGCAGGATTGGTATTTGTATGCTTACTGTCTCTTAAGGCAGAACTATCGCTTTTTCAAACTGTCACGAATCAAAGAGTGGCAGATCTCAAGCGATTGTTTTGAAGATGATTTTTCAGAAATACTGATTAAAACGGATTTTGATTATGATTCGACGGTACATCTATCTCTTAAATTTGCTCCTCAGTTAGCCTTTCGCGTTTATGATGAATTTTCGGATGTCACTGCAGATCAGGAGGGTTCTTTATATGCAGAAATTGATCTTCCTGATAATGATGTTTTGGAAAGTTACCTTTTATCGTTTGGAGAAGGTCTAGAAGTCTTACAACCTGAGACTTTACGTCAAGCCATTCAGAAAAAATTGAAGAAAATGTTAACAATTTATAAAACCTGA","7.90","1.59","34710","MRESRLFQIIYQLLTKKKVTAANLAKQFEVSVRTIYRDIDALSSSGIPIYASQGKNGGIQLDEDFVLSKSLLSQEEKEQILDGLQGLGSVNGIVNDKQLLTKLSALFKVKNPNWIEVQFSPWQNHDQQQKLVQLIKEAICQKHFFSFLYFSSLAKQTKRKVKPVRLVFKGQDWYLYAYCLLRQNYRFFKLSRIKEWQISSDCFEDDFSEILIKTDFDYDSTVHLSLKFAPQLAFRVYDEFSDVTADQEGSLYAEIDLPDNDVLESYLLSFGEGLEVLQPETLRQAIQKKLKKMLTIYKT","1397199","","conserved hypothetical protein","Cytoplasm","Few hits in gapped BLAST to conserved hypotheticals and to transcription regulators. Residues 1-297 are 41% similar to gi|15896731| as seen in B.subtilis.Residues 1-298 are 33% similar to gi|5759267| as seen in Enterococcus faecium.SMu1338 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001034
Domain

Bacterial regulatory protein, DeoR N-terminal
SM00420	$\"[5-61]T$	HTH_DEOR
PS51000	$\"[2-57]T$	HTH_DEOR_2

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[5-60]T$	HTH_11

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-64]T$	SSF46785

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 146-203 are 46% similar to a (REGULATOR PROTEOME TRANSCRIPTIONAL) protein domain (PD021258) which is seen in O34920_BACSU.Residues 1-125 are 43% similar to a (PROTEOME TRANSCRIPTION COMPLETE) protein domain (PD267538) which is seen in Q9S3S5_ENTFC.Residues 4-86 are 38% similar to a (REGULATOR TRANSCRIPTIONAL DNA-BINDING) protein domain (PD014122) which is seen in Q9S2Q2_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 12 09:00:13 2002","Tue Mar 12 08:59:31 2002","Tue Mar 12 09:00:13 2002","Tue Mar 12 08:59:31 2002","","Tue Mar 12 08:59:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1338 is paralogously related (blast p-value < 1e-3) to SMu1535, a predicted conserved hypothetical protein.","Tue Mar 12 08:59:31 2002","","No significant hits to the NCBI PDB database.","SMU.1471c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 08:59:31 2002","24379866","","","","","","1","","","SMU.1471c","" "SMu1339","1400407","1398203","2205","ATGATTACTTCCAAATATGCTTGGAAAATAAATGAAAAAAAGCCAGATGATGGCTTTTTTGAGCTGGCTAAAAAAGAAAATCTCAATCCTACAGCTGCACAAATTTTATATGAGCGAGGTTTTAAAACAAGTAAAGATATAGAAGCGTTTTTGAGACCTGATTTGTCTCAATTACATGATCCCTTTCTTTTAAATGATATGGACAAGGCTGTCACGCGTATTCGCAGAGCTATTGAAACCAATGAACGAATTCTTATCTATGGGGATTACGATGCTGATGGTATGACGTCAAGTTCCATTGCAAAGGAAGCTTTGGAAATGCTGGGAGCTGAGGTAGAGGCTTATCTTCCTAATCGTTTTACCGATGGTTATGGTCCCAATCTCAGTGTTTATAAATATTTTATTGAGCAGCAGGATATATCACTGATTCTTACTGTGGATAATGGTATTGCTGGCCATGATGCTATTGCTTATGCGCAAGGACAAGGTGTTGATGTCATTGTTACTGACCACCACAGTATGCCTGCTGAGCTTCCTTCAGCTTATGCTGTCGTTCATCCTGAACATCCAGATGCTAATTATCCTTTTAAATGTTTAGCAGGGTGCGGTGTCGCTTTTAAGCTAGCCTGTGCCTTGTTAGAATCCATTCCGACAGAGATGCTGGATTTGGTGGCTATTGGAACCATTGCCGATATGGTATCGCTCACCGATGAAAATCGTGTAATGGTCAAATACGGTCTTGAAATCCTAAAACAAACAGAGCGCGTCGGTCTGCAAGAATTAATAGCACTTGCAGGTGTTGATTTTGCTGATATCAATGAAGAAACCATTGGTTTCAAGTTAGCACCCCAGCTTAATGCTTTGGGACGTCTGGATGATCCCAATCCTGCTGTTGAATTGTTGACAGGCTTTGATGATGAAGAAGCAAAGACTATTGCGGCCATGATTAATGAAAAAAATGAGGAGCGAAAGACCATTGTACAGGCTATTTTTGAAGAAGCTATGACTCTGGTTGATGAGAACAAATCTGTTCAGGTCTTGGCTAAAGAAGGCTGGCATGCTGGTGTTCTGGGGATTGTTGCAGGTCGTATTATGGAACAAATAAACCAGCCAGTCATTGTTCTTAATATTGAAAATGGCCTTGCCAAGGGAAGTGCCCGTAGTTTAGAGTCAGTCAATATTTTTAATGCCCTTGATGCGCATAGGGATTTATTTATGGCTTTTGGAGGCCATGCTGGAGCTGCAGGTATGACTCTAGAGGCTGATAAATTAGAAGAATTATCACAGGTTTTAAATGATTATATTCAAGAACATGCGATTGATTTATCGCAAAAGTCTGCTTTAGTAATTGATGAAGAATTGTACTTGCCAGAACTTAGTTTAGATACTTTAAAAGGGCTTGAAACTTTGGCTCCTTTTGGTATGAACAATAAAAAACCTATTTTTTTACTAAGGGATTTTACAGTCAAACAGGTTAGAACGATGGGACAAAATGGAGCTCATTTGAAGTTAAAAGTGGCTCAGGAACAGGCTGTCTTTGATCTCCTTGCCTTTAACTACGGTTCGCTCGTGACAGAATTTCAACAAGCTCAGCATCTCGAACTAGCTGTTACTTTATCGGTTAATCGTTGGAACGGCAATACTAGTCTACAATTGATGCTAGTTGATGCGCGTGTTGAAGGCATTCAGTTGCTTGATATCCGTGCTCGCAATAGCGCTCTGCCTGACGGAGTTCCCTTTTTAGAAGATCAAACAGATAGTAAGGCAGTTGTCTTATTTGAAATACCGGAAAAAGAAGAAGACCTTCTAGCACTTTTTGAAAATCGGGATTTTGAAGTCATTTATTTTAAAAATAGGATTAAGCATCAATATTATTTAACAGGATCTGGAACGCGTGAGCAATTTGCTAAGCTTTACAAGACGATTTACCAGTTTCCGGAATTTGATGTACGTCATAAGTTAAAAGAGCTCAGTCAATTTCTCAAAATTCCAGATATTTTGCTGGTCAAGATGATCCAAATTTTTGATGAATTGGACTTTGTTTCCATTGATGATGGCATTATGACAGTTAATAAAGATGCTCAAAAACGGGAAATTTCTGACAGTCATATTTATCAAGATTTGAAAAAATTAGTGAAATTCCAAGAGTTAATGGCATTAGGAACACCTCAAGAAATATATGAATTTTTAAAACGCGATCGCTAA","4.60","-38.42","82404","MITSKYAWKINEKKPDDGFFELAKKENLNPTAAQILYERGFKTSKDIEAFLRPDLSQLHDPFLLNDMDKAVTRIRRAIETNERILIYGDYDADGMTSSSIAKEALEMLGAEVEAYLPNRFTDGYGPNLSVYKYFIEQQDISLILTVDNGIAGHDAIAYAQGQGVDVIVTDHHSMPAELPSAYAVVHPEHPDANYPFKCLAGCGVAFKLACALLESIPTEMLDLVAIGTIADMVSLTDENRVMVKYGLEILKQTERVGLQELIALAGVDFADINEETIGFKLAPQLNALGRLDDPNPAVELLTGFDDEEAKTIAAMINEKNEERKTIVQAIFEEAMTLVDENKSVQVLAKEGWHAGVLGIVAGRIMEQINQPVIVLNIENGLAKGSARSLESVNIFNALDAHRDLFMAFGGHAGAAGMTLEADKLEELSQVLNDYIQEHAIDLSQKSALVIDEELYLPELSLDTLKGLETLAPFGMNNKKPIFLLRDFTVKQVRTMGQNGAHLKLKVAQEQAVFDLLAFNYGSLVTEFQQAQHLELAVTLSVNRWNGNTSLQLMLVDARVEGIQLLDIRARNSALPDGVPFLEDQTDSKAVVLFEIPEKEEDLLALFENRDFEVIYFKNRIKHQYYLTGSGTREQFAKLYKTIYQFPEFDVRHKLKELSQFLKIPDILLVKMIQIFDELDFVSIDDGIMTVNKDAQKREISDSHIYQDLKKLVKFQELMALGTPQEIYEFLKRDR","1398218","For other 'rec' genes see SMu0021 (recO);SMu0532 (recN); SMu0545 (recR),(recM);SMu1956 (recF); SMu1892 (recA) ; SMu0425 (recU); SMu1669 (recG) and SMu1705 (recD).This gene falls within the designated TnSmu2 region (Waterhouse and Russell, 2006).","single-strand DNA-specific exonuclease","Cytoplasm","Several matches in gapped BLAST to single-strand DNA-specific exonuclease: residues 1-730 are 65% similar to the enzyme in S.pyogenes (gi15674946) and 63% similar to the protein from S.pneumoniae (gi15902581).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1208 (0.0).","

InterPro
IPR001667
Domain

Phosphoesterase, RecJ-like
PF01368	$\"[77-229]T$	DHH

InterPro
IPR003156
Domain

Phosphoesterase, DHHA1
PF02272	$\"[369-433]T$	DHHA1

InterPro
IPR004610
Family

Bacterial RecJ exonuclease
TIGR00644	$\"[28-557]T$	recJ

noIPR
unintegrated

unintegrated
SSF64182	$\"[58-450]T$	SSF64182

","BeTs to 13 clades of COG0608COG name: Single-stranded DNA-specific exonucleaseFunctional Class: LThe phylogenetic pattern of COG0608 is AMTk-qvceB-hUJ--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001667 (DHH family) with a combined E-value of 1.3e-11. IPB001667A 89-102 IPB001667B 166-173 IPB001667C 408-416","Residues 504-732 are 25% similar to a (PROTEOME EXONUCLEASE COMPLETE YRVE) protein domain (PD133429) which is seen in O32044_BACSU.Residues 221-330 are 71% similar to a (EXONUCLEASE PROTEOME COMPLETE) protein domain (PD007759) which is seen in Q9CHT6_LACLA.Residues 491-730 are 54% similar to a (EXONUCLEASE PROTEOME COMPLETE SPECIFIC) protein domain (PD401022) which is seen in Q9CHT6_LACLA.Residues 8-95 are 52% similar to a (EXONUCLEASE PROTEOME COMPLETE) protein domain (PD112144) which is seen in Q9CHT6_LACLA.Residues 96-213 are 70% similar to a (EXONUCLEASE PROTEOME COMPLETE) protein domain (PD003186) which is seen in Q9CHT6_LACLA.Residues 97-214 are 38% similar to a (EXONUCLEASE PROTEOME COMPLETE RECJ) protein domain (PD017509) which is seen in Q9PJ83_CAMJE.Residues 341-489 are 44% similar to a (EXONUCLEASE PROTEOME COMPLETE) protein domain (PD009926) which is seen in Q9CHT6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:52:00 2007","Tue Mar 12 09:03:55 2002","Thu Aug 10 09:02:48 2006","Tue Mar 12 09:03:55 2002","Tue Mar 12 09:03:55 2002","Tue Mar 12 09:03:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1339 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 12 09:05:01 2002","","No significant hits to the NCBI PDB database.","SMU.1472c","","Residues 77 to 229 (E-value = 1.6e-54) place SMu1339 in the DHH family which is described as DHH family (PF01368)Residues 369 to 433 (E-value = 2.9e-15) place SMu1339 in the DHHA1 family which is described as DHHA1 domain (PF02272)","Thu Aug 10 09:02:48 2006","","","Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","Lovett,S.T. and Kolodner,R.D.Nucleotide sequence of the Escherichia coli recJ chromosomal region and construction of recJ-overexpression plasmidsJ. Bacteriol. 173 (1), 353-364 (1991)PubMed: 1987126","Tue Apr 24 10:52:00 2007","Tue Mar 12 09:06:47 2002","1","","","SMU.1472c","135" "SMu1340","1401168","1400404","765","ATGAAAGAACGTATAATTGTCATTACAGGTGCCTCAGGGGGGCTTGCTGAAGAAATCATTAAACGCTTACCGCAGACAGATCAACTTGTTTTATTGGGCCGTGATAAGGAAAAATTAGAAGACATGTATGCCTATCGTGAAAGAGTAACTTGTTTTCAAATTGATATTAAAGATGATGAGGCTGTGCAGGATATAATTGACACCATTTATCAAAAATTTGACCGCATCGATATTTTTATTAACAATGCAGGCTTTGGTGAATTTAAAGACTTTGATCACTATTCTAACAGAGACATTCGAGACATGTTTGATGTCAATACTTTGGCAACCATCAATTTTTCTCGTTTGGTTGGTCAAAAGATGGCAGAGGTTCAGTCAGGGCATATTATCAATATTGCTAGTATGGCGGGCTTGATTGCTTCTAGTAAATCAACGATTTATTCAGCCACCAAGTTTGCAGTGATTGGTTTTTCAAATGCTTTGCGTTTAGAATTAGCAGACAAAGAAGTTTATGTCACGACTGTTAATCCGGGACCGATTGCCACTAAATTTTTTGATAAGGCAGATCCTAGCGGCAATTATCTTAAGAGCGTTGAAGAATTCACTTTGCAGCCTGATGATGTTGCCAAAAAAATAGTTGCTATTTTTGGAAAAAATAAACGCGAACTCAATATGCCTTTTCTACTAAAGGCGGCGCATAAAGCCTATATTCTCTTTCCTAAATTGTCGGATTTTCTAACCAGAAAGGTATTTAACTACAAATGA","7.60","0.68","28804","MKERIIVITGASGGLAEEIIKRLPQTDQLVLLGRDKEKLEDMYAYRERVTCFQIDIKDDEAVQDIIDTIYQKFDRIDIFINNAGFGEFKDFDHYSNRDIRDMFDVNTLATINFSRLVGQKMAEVQSGHIINIASMAGLIASSKSTIYSATKFAVIGFSNALRLELADKEVYVTTVNPGPIATKFFDKADPSGNYLKSVEEFTLQPDDVAKKIVAIFGKNKRELNMPFLLKAAHKAYILFPKLSDFLTRKVFNYK","1400419","This gene falls within the designated TnSmu2 region (Waterhouse and Russell, 2006).","oxidoreductase, short chain dehydrogenase/reductase family","Cytoplasm","This sequence corresponds to the previously published gi4928282 and gi11250508 in GenBank.Residues 4-178 are 26% similar to sorbitol-6-phosphate dehydrogenase from S.mutans.Matches in gapped BLAST to oxidoreductase, short-chain dehydrogenase/reductase. Residues 1-254 are 66% similar to gi15674945 from S.pyogenes. Residues 6-254 are 60% similar to the protein gi15900576 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1209 (2e-89).","

InterPro
IPR002198
Family

Short-chain dehydrogenase/reductase SDR
PR00080	$\"[74-85]T$ $\"[127-135]T$ $\"[147-166]T$	SDRFAMILY
PTHR19410	$\"[1-224]T$	ADH_short_C2
PF00106	$\"[4-166]T$	adh_short
PS00061	$\"[134-162]T$	ADH_SHORT

InterPro
IPR002347
Family

Glucose/ribitol dehydrogenase
PR00081	$\"[5-22]T$ $\"[74-85]T$ $\"[121-137]T$ $\"[147-166]T$ $\"[168-185]T$	GDHRDH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[2-244]T$	G3DSA:3.40.50.720
PTHR19410:SF44	$\"[1-224]T$	PTHR19410:SF44
SSF51735	$\"[2-253]T$	SSF51735

","BeTs to 5 clades of COG0300COG name: Short-chain dehydrogenases of various substrate specificitiesFunctional Class: RThe phylogenetic pattern of COG0300 is ----y--ceBRhuj-------Number of proteins in this genome belonging to this COG is 3","***** IPB002198 (Short-chain dehydrogenase/reductase (SDR) superfamily) with a combined E-value of 4.1e-14. IPB002198 127-162","Residues 127-166 are 72% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD003795) which is seen in YQJQ_BACSU.Residues 171-254 are 50% similar to a (OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD059934) which is seen in YQJQ_BACSU.Residues 4-121 are 40% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE) protein domain (PD395619) which is seen in Q9CHT7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:51:42 2007","Wed Aug 30 16:00:30 2006","Wed Aug 30 16:00:30 2006","Tue Mar 12 09:18:05 2002","Tue Mar 12 09:18:05 2002","Tue Mar 12 09:18:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1340 is paralogously related (blast p-value < 1e-3) to SMu0949 and SMu1919, a predicted oxidoreductase, short-chain dehydrogenase /reductase; SMu1586, a predicted beta-ketoacyl-ACP reductase; SMu1207,a predicted acetoin reductase; and SMu0278, a predicted sorbitol-6-phosphate 2-dehydrogenase.","Tue Mar 12 09:21:41 2002","Wed Aug 30 16:00:30 2006","pdb1I01A Chain A, Crystal Structure Of Beta-Ketoacyl [acyl Ca... 75 1e-014pdb1EDOA Chain A, The X-Ray Structure Of Beta-Keto Acyl Carri... 74 2e-014pdb1HDCA Chain A, 3-Alpha, 20-Beta-Hydroxysteroid Dehydrogena... 69 7e-013","SMU.1473c","","Residues 6 to 251 (E-value = 2.8e-38) place SMu1340 in the adh_short family which is described as short chain dehydrogenase (PF00106)","Tue Mar 12 09:18:05 2002","24379868","","Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:54:56 2007","","1","","","SMU.1473c","575" "SMu1341","1402094","1401165","930","ATGGAAATTCAATTTTTAGGAACGGGTGCTGGCCAGCCAGCTAAGGCGAGAAATGTTTCCAGCCTCGTTTTAAAGCTGTTAGATGAACTTAATGAAATTTGGATGTTTGATTGCGGTGAAGGAACGCAGCGTCAAATTTTAGAAACAACTATTAAACCGCGTAAAATTAGAAAAATCTTTATTACCCACCTGCATGGTGACCATGTTTTTGGTTTGCCGGGATTTTTATCCAGCCGTGCTTTTCAAGCCAATGACGAACAGACAGATGTTGATATTTATGGACCGGTTGGTATTAAACATTTAGTTATGGCTAGCATACGTACTTCGGGAGCTCATTTACCTTATCACATTCATTTTCATGAATTTGATGCTAAGCATTTAGGGAAAATTTTAGAAACCGATAAGTTTATGGTTTATGCGGAAAAGCTAGATCACACGATTTTTTGTGTTGGTTATCGTGTTGTTCAAAAAGATTTAGAAGGGACGCTGGATGCTGAGAAATTAAAAGCAGCAGGTTTACCTTTTGGTCCGCTTTTTGGTCGGGTCAAAAATGGTCAGGATGTCGTTTTAGAAGATGGGACGACAATTATTGCTAAAGACTATATTTCGGCTCCGAAAAAGGGCAAGGTTATTACTATTTTAGGAGATACCCGAAAAACAGATGCCAGTATTCGACTTGCTTTGGGAGCTGATGTACTGGTTCATGAGTCCACTTATAGTAAGGGAGATGAGAATTTAGCGAGGCGTCATGGGCATTCAACTAATACGGAAGCTGCTCGTGTTGCAAAAGCCGCTTCTGTTAAGAAATTGCTACTTAATCACATCAGTGCTCGTTTTCTTTCACATGATATTAGCCGCATGAGAGATGATGCACAGGAAATCTTTACTGATGTTCATATTGTCAGAGACTTAGAAGAAGTAAAACTATGA","7.80","3.77","34397","MEIQFLGTGAGQPAKARNVSSLVLKLLDELNEIWMFDCGEGTQRQILETTIKPRKIRKIFITHLHGDHVFGLPGFLSSRAFQANDEQTDVDIYGPVGIKHLVMASIRTSGAHLPYHIHFHEFDAKHLGKILETDKFMVYAEKLDHTIFCVGYRVVQKDLEGTLDAEKLKAAGLPFGPLFGRVKNGQDVVLEDGTTIIAKDYISAPKKGKVITILGDTRKTDASIRLALGADVLVHESTYSKGDENLARRHGHSTNTEAARVAKAASVKKLLLNHISARFLSHDISRMRDDAQEIFTDVHIVRDLEEVKL","1401180","This gene falls within the designated TnSmu2 region (Waterhouse and Russell, 2006).","ribonuclease Z","Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-307 are 74% similar to gi15674944 from S.pyogenes. Residues 1-309 are 56% similar to gi15672612 from L.lactis lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1210 (1e-142).","

InterPro
IPR001279
Domain

Beta-lactamase-like
PF00753	$\"[18-274]T$	Lactamase_B

InterPro
IPR013471
Family

Ribonuclease Z
TIGR02651	$\"[2-309]T$	RNase_Z

noIPR
unintegrated

unintegrated
G3DSA:3.60.15.10	$\"[1-309]T$	G3DSA:3.60.15.10
PTHR12553	$\"[33-307]T$	PTHR12553
PTHR12553:SF6	$\"[33-307]T$	PTHR12553:SF6
SSF56281	$\"[1-260]T$	SSF56281

","BeTs to 13 clades of COG1234COG name: Metal-dependent hydrolases of the beta-lactamase superfamily IIIFunctional Class: RThe phylogenetic pattern of COG1234 is Amtky-vceBR-----oLin-Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 32-76 are 86% similar to a (COMPLETE PROTEOME HYDROLASE FACTOR POLYADENYLATION) protein domain (PD000482) which is seen in Q9CHT8_LACLA.Residues 208-279 are 45% similar to a (PROTEOME COMPLETE ELAC2 CHROMOSOME) protein domain (PD352433) which is seen in Q9CHT8_LACLA.Residues 97-191 are 56% similar to a (PROTEOME COMPLETE ELAC1 GLNQ-ANSR) protein domain (PD339363) which is seen in Q9CHT8_LACLA.Residues 1-99 are 48% similar to a (COMPLETE PROTEOME HYDROLASE ELAC2) protein domain (PD003027) which is seen in Q9H777_HUMAN.Residues 4-104 are 34% similar to a (ELAC2 I HPC2/ELAC2 CG3298) protein domain (PD104861) which is seen in Q9M819_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:52:15 2007","Wed Sep 13 15:56:42 2006","Wed Sep 13 15:56:42 2006","Tue Mar 12 09:26:01 2002","","Tue Mar 12 09:26:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1341 is paralogously related (blast p-value < 1e-3) to SMu0274, a predicted conserved hypothetical protein.","Wed Sep 13 15:56:42 2006","","No significant hits to the NCBI PDB database.","SMU.1474c","","Residues 18 to 274 (E-value = 7.5e-13) place SMu1341 in the Lactamase_B family which is described as Metallo-beta-lactamase superfamily (PF00753)","Tue Mar 12 09:26:01 2002","24379869","","Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:54:31 2007","","1","","","SMU.1474c","397" "SMu1342","1402757","1402122","636","GTGAATTATCTTGATTTAGCCCTTAAGTATGGTGGTTTTACTAGCTTAGATAAGGTTTACTTGCAAAACAAGTTAGCCTTTTTGTCAGATGAGGAAAAATTAAGCTTTATCACACCGCCGCCAAGCGTTATCAATGCTTATTTTGCGGAACTTTATCAAAAGGAATCTCCTCAGGCCGCAACAGATTATTATTTTGAATTGAGTCGGAACCTACATTTATTTACGGATAAACCATCGTTTGATGAACAAAAGCCTTTTGTTCGGCTTAATTTATCAGGAAAATCGTATGGGTTTGCTTATGAAAATGAAGAGGAAGAAGCGCAGGTCTTTAGTGAAAAAAAGGAAGAAATTACTGACAGTCTCTTATTTGACTTAGCTCAGATATTTCCCCAGTATAAAATTTTTAGCGACAATCAACAAATTAAAATGAAAAAAATGAACTTTGATGAGTATCAAAGTGAAACATTGGAAAATGCTGCAGCTTTGCTCAGCGACATTAGCCGTCTGCAAGATGGCACGATTAAAATAAGAAGTTTCAATCAGGAAGAAGTTATAGAATTAGCACAGGCCTACTCAGGACGCAGATACTACAGTTATGCTCAGAATCAGGCAGTGCTTTACCTCAAAGAAGATTAA","4.50","-11.74","24569","MNYLDLALKYGGFTSLDKVYLQNKLAFLSDEEKLSFITPPPSVINAYFAELYQKESPQAATDYYFELSRNLHLFTDKPSFDEQKPFVRLNLSGKSYGFAYENEEEEAQVFSEKKEEITDSLLFDLAQIFPQYKIFSDNQQIKMKKMNFDEYQSETLENAAALLSDISRLQDGTIKIRSFNQEEVIELAQAYSGRRYYSYAQNQAVLYLKED","1402137","This gene falls within the designated TnSmu2 region (Waterhouse and Russell, 2006).","conserved hypothetical protein","Cytoplasm","Similarities to previously published sequence gi1877423, gi7448853 and gi2494675 in Genbank.Limited matches in gapped BLAST to hypotheticals: residues 2-210 are 57% similar to gi15674943 from S.pyogenes and residues 6-208 are 52% similar to gi15900574 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1211 (3e-70).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-189 are 43% similar to a (PROTEOME COMPLETE) protein domain (PD400587) which is seen in Q9CHU1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:52:33 2007","Tue Mar 12 09:30:53 2002","Tue Apr 24 10:52:33 2007","Tue Mar 12 09:30:53 2002","","Tue Mar 12 09:30:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1342 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 24 10:52:33 2007","","No significant hits to the NCBI PDB database.","SMU.1475c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 09:30:53 2002","24379870","","Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:54:10 2007","","1","","","SMU.1475c","690" "SMu1343","1403991","1402744","1248","ATGATTGAAACAAGACAAAAACAAGAACGGGTCATTCTTATTGGTGTCGCTTTACCAAATAGTGAAAATTTCGATCTGTCTATGGAAGAATTAGCCAGTCTTGCGAAAACTGCAGGAGCTGAGGTCGTTCAGACACACACTCAAAAAAGAGACCACTATGACAGTAAGAGTTTCATTGGTTCAGGAAAATTACTTGAAATCAAGCAAATAATTGCAACGGACGCTATTGATAGCGTCATTGTTAATAATCGTTTGACACCTCGCCAGAATGCCTATTTGGAAGCAGAACTAGGAGTTAAAGTTATTGATCGCATGCAGCTTATTTTAGATATTTTTGCCATGCGGGCACGCAGTCACGAAGGCAAACTTCAGGTTCATTTAGCCCAACTTAAATACATGCTGCCGCGTCTTGTTGGGCAGGGTATCATGCTCAGCCGTCAGGCTGGGGGTATCGGCAGCCGTGGTCCCGGTGAAAGCCAATTAGAATTGAATCGCCGTTCTATTCGCAAGCAAATTGCAGATATTGAACGGCAACTGAAAAATGCTGAAAAAAATCGGGAAACAAACCGCGAAAAACGCTTGGATTCGCAAATTTTTAAAATTGGGCTGATTGGTTATACCAATGCGGGCAAGTCAACCATCATGAATGTTTTGACTGATAATAAGCAGTATGAGGCTGATGAACTGTTTGCTACACTTGATGCGACAACCAAGCAAATTTATTTGACAGATCATTTTCAAGCTACTTTGACGGATACCGTTGGCTTTATTCAGGATTTGCCAACCGAACTGGTTGCTGCTTTCAAGTCAACGCTTGAGGAAAGCCGACAAGTGGATTTGTTGCTTCATGTTATTGATGCCAGTGATCCTAATCATGAAGAGCATGAAAAAGTTGTTCATGATCTTTTAAAGGAACTTGGTATGACAGCCATTCCTCGATTGCTTGTTTACAATAAAATGGATAAGGCAGAAAATTTCATTGCCAGCCAATTTCCTCACATCAGCCTGTCTGCTAAGTCTGATGAGGCGGCAGCACTTTTACGTCAGTCTATTTTGGAAAAGATCAAGACTCTTTTTGTTCCTTTTACGATTACATGGCGTCAAGAAAAAAGCTATAAACTTTATGAATTGGACAAAATAGCCTTGCTGACTTCTTATGATGTTAAGCAAGAACTGCAAGAAATTAAAGGTTACATTTCGGAAAAAAATAAATGGAGGCTAGAGGAGTTTTATCGTGAATTATCTTGA","6.90","-0.55","47316","MIETRQKQERVILIGVALPNSENFDLSMEELASLAKTAGAEVVQTHTQKRDHYDSKSFIGSGKLLEIKQIIATDAIDSVIVNNRLTPRQNAYLEAELGVKVIDRMQLILDIFAMRARSHEGKLQVHLAQLKYMLPRLVGQGIMLSRQAGGIGSRGPGESQLELNRRSIRKQIADIERQLKNAEKNRETNREKRLDSQIFKIGLIGYTNAGKSTIMNVLTDNKQYEADELFATLDATTKQIYLTDHFQATLTDTVGFIQDLPTELVAAFKSTLEESRQVDLLLHVIDASDPNHEEHEKVVHDLLKELGMTAIPRLLVYNKMDKAENFIASQFPHISLSAKSDEAAALLRQSILEKIKTLFVPFTITWRQEKSYKLYELDKIALLTSYDVKQELQEIKGYISEKNKWRLEEFYRELS","1402759","This gene falls within the designated TnSmu2 region (Waterhouse and Russell, 2006).","GTP-binding protein","Cytoplasm","Similarities to previously published sequence gi2749952, gi541363 and gi585107 in Genbank. Several matches in gapped BLAST to GTP-binding proteins: residues 1-411 are 72% similar to gi15674942 from S.pyogenes and are 69% similar to gi15900573 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1212 (1e-173).","

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[199-321]T$	MMR_HSR1

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[196-360]T$	small_GTP

InterPro
IPR006073
Domain

GTP1/OBG
PR00326	$\"[201-221]T$ $\"[268-286]T$	GTP1OBG

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[198-369]T$	G3DSA:3.40.50.300
PTHR10229	$\"[66-411]T$	PTHR10229
SSF52540	$\"[199-378]T$	SSF52540

","BeTs to 9 clades of COG2262COG name: GTPasesFunctional Class: RThe phylogenetic pattern of COG2262 is Amtky-vceBR-----oLin-Number of proteins in this genome belonging to this COG is 1","***** IPB000765 (GTP1/OBG family) with a combined E-value of 1e-11. IPB000765 199-242***** PR00449 (Transforming protein P21 RAS signature) with a combined E-value of 2.6e-07. PR00449A 199-220 PR00449B 263-279 PR00449D 309-322 PR00449E 333-355","Residues 28-135 are 64% similar to a (PROTEOME COMPLETE GTP-BINDING HFLX) protein domain (PD006242) which is seen in Q9CIY3_LACLA.Residues 144-193 are 46% similar to a (PROTEOME BINDING COMPLETE NMA1445) protein domain (PD412206) which is seen in Q9JU87_NEIMA.Residues 136-180 are 57% similar to a (PROTEOME COMPLETE GTP-BINDING HFLX) protein domain (PD410881) which is seen in Q9WYZ7_THEMA.Residues 162-257 are 61% similar to a (GTP-BINDING PROTEOME COMPLETE HFLX) protein domain (PD235653) which is seen in Q9CIY3_LACLA.Residues 332-407 are 38% similar to a (PROTEOME GTP-BINDING COMPLETE HFLX) protein domain (PD391482) which is seen in Q9CIY3_LACLA.Residues 201-267 are 53% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9HUM1_PSEAE.Residues 271-324 are 51% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in Q9PH58_XYLFA.Residues 258-323 are 63% similar to a (PROTEOME COMPLETE GTP-BINDING HFLX) protein domain (PD002733) which is seen in Q9CIY3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:53:19 2007","Tue Mar 12 09:39:56 2002","Tue Apr 24 10:53:19 2007","Tue Mar 12 09:39:56 2002","Tue Mar 12 09:39:56 2002","Tue Mar 12 09:39:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1343 is paralogously related (blast p-value < 1e-3) to SMu0727, SMu1471, and SMu0004 all predicted GTP-binding proteins.","Tue Mar 12 09:41:44 2002","","No significant hits to the NCBI PDB database.","SMU.1476c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 09:39:56 2002","24379871","","Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","Noble,J.A., Innis,M.A., Koonin,E.V., Rudd,K.E., Banuett,F. andHerskowitz,I.The Escherichia coli hflA locus encodes a putative GTP-bindingprotein and two membrane proteins, one of which contains aprotease-like domainProc. Natl. Acad. Sci. U.S.A. 90 (22), 10866-10870 (1993)PubMed: 8248183Banuett,F. and Herskowitz,I.Identification of polypeptides encoded by an Escherichia coli locus (hflA) that governs the lysis-lysogeny decision of bacteriophage lambdaJ. Bacteriol. 169 (9), 4076-4085 (1987)PubMed: 3040675","Tue Apr 24 10:53:50 2007","Tue Mar 12 09:39:56 2002","1","","","SMU.1476c","398" "SMu1344","1405064","1404180","885","ATGAAAACAAAATTAATTGTTGTTTTAGGTCCAACGGCAGTCGGAAAAACAGCACTGGGAATTAAATTAGCCCAGCAATTTCATGGTGAAATTATTAGCGGTGACAGTCAGCAGGTTTATCGAAAGTTAGATATTGGTACGGCTAAGGCCACGGCTGCCGAACAAGCAGCAGTTCCACATCATTTGATTGATGTTAGAGAGGTAGATGAGAATTATTCTGCCTTTGATTTTGTTCAGGAAGCAACAAAAGAAATTGCCAATATTTGCGCTCGAGGTTATCTTCCTATTATTGTCGGTGGTACTGGGCTTTATTTACAAAGTCTTCTGGAAGGTTATCATTTGGGAGGCCAAGTTGATCATGAAGCTGTTTTAGCCTATCGAAGAGAATTGGAAACCTTATCTGATACAGAACTTTCTCAGTTAGTTGAAACAAAACAAATTGTTATGACAGAACCTAATCGTCGACGTTTGATGCGTTCCTTGGAACTCCACAAATTTAGCCAAGGTGTCCAAAATCAAGGAAGTCCTTATGATGTTTTATTGATTGGTTTAAATGATAATCGGCAAGATCTTTATGAACGCATTAATGCTCGCGTTGATAAGATGATGGCAGCAGGATTGTTAGACGAAGCCAAGTGGTTGTATGATAATTATCCTCATGCACAAGCAACTCGCGGAATTGGCTACAAGGAACTCTTTCCTTATTTTGCAGGTGATATTGGTTTGGAAGAGGCTGTTGAAAAAATTAAGCAAAACACAAGACGTTTTGCTAAACGGCAGTTGACTTGGTTTAAAAACCGTATGGCTGTTTCATTTTATTCGGTCAGTGATTCGGACTACAAGGGAAAAATCAATCAGGCTGTTGTCGATTTTTTAAGAAATTAG","7.20","0.65","33160","MKTKLIVVLGPTAVGKTALGIKLAQQFHGEIISGDSQQVYRKLDIGTAKATAAEQAAVPHHLIDVREVDENYSAFDFVQEATKEIANICARGYLPIIVGGTGLYLQSLLEGYHLGGQVDHEAVLAYRRELETLSDTELSQLVETKQIVMTEPNRRRLMRSLELHKFSQGVQNQGSPYDVLLIGLNDNRQDLYERINARVDKMMAAGLLDEAKWLYDNYPHAQATRGIGYKELFPYFAGDIGLEEAVEKIKQNTRRFAKRQLTWFKNRMAVSFYSVSDSDYKGKINQAVVDFLRN","1404195","","tRNA isopentenylpyrophosphate transferase","Cytoplasm","Several matches in gapped BLAST to tRNA isopentenylpyrophosphate transferase: residues 2-292 are 61% similar to the enzyme in S.pyogenes (gi15674941). Residues 1-292 are 60% similar to the protein from S.pneumoniae (gi15900572).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1213 (1e-107).","

InterPro
IPR002627
Family

tRNA isopentenyltransferase
PD004674	$\"[63-111]T$	IPPT
PTHR11088	$\"[36-280]T$	IPPT
PF01715	$\"[37-276]T$	IPPT
TIGR00174	$\"[5-278]T$	miaA

InterPro
IPR011593
Domain

Isopentenyl transferase-like
PD005388	$\"[4-47]T$	IPPtrans_like

noIPR
unintegrated

unintegrated
PTHR11088:SF21	$\"[36-280]T$	PTHR11088:SF21
SSF52540	$\"[2-254]T$	SSF52540

","BeTs to 12 clades of COG0324COG name: tRNA delta(2)-isopentenylpyrophosphate transferaseFunctional Class: JThe phylogenetic pattern of COG0324 is ----yqvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002627 (IPP transferase) with a combined E-value of 1.2e-62. IPB002627A 30-65 IPB002627B 88-118 IPB002627C 142-169 IPB002627D 191-214 IPB002627E 253-265***** IPB002648 (Isopentenyl transferase) with a combined E-value of 2.6e-06. IPB002648A 5-30 IPB002648B 31-68","Residues 4-36 are 78% similar to a (TRANSFERASE TRNA IPP) protein domain (PD402523) which is seen in MIAA_LACLA.Residues 38-268 are 59% similar to a (TRANSFERASE TRNA ISOPENTENYLTRANSFERASE) protein domain (PD004674) which is seen in MIAA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 12 09:45:40 2002","Tue Mar 12 09:44:39 2002","Wed Sep 13 16:03:37 2006","Tue Mar 12 09:44:39 2002","Tue Mar 12 09:44:39 2002","Tue Mar 12 09:44:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1344 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 12 09:45:40 2002","","No significant hits to the NCBI PDB database.","SMU.1477c","","Residues 37 to 276 (E-value = 1.3e-70) place SMu1344 in the IPPT family which is described as IPP transferase (PF01715)","Tue Mar 12 09:44:39 2002","","","","Connolly,D.M. and Winkler,M.E.Structure of Escherichia coli K-12 miaA and characterization of the mutator phenotype caused by miaA insertion mutationsJ. Bacteriol. 173 (5), 1711-1721 (1991)PubMed: 1999389Connolly,D.M. and Winkler,M.E.Genetic and physiological relationships among the miaA gene,2-methylthio-N6-(delta 2-isopentenyl)-adenosine tRNA modification,and spontaneous mutagenesis in Escherichia coli K-12J. Bacteriol. 171 (6), 3233-3246 (1989)PubMed: 2656644","","Tue Mar 12 09:49:55 2002","1","","","SMU.1477c","399" "SMu1345","1405139","1405315","177","ATGGCTAAGAAACATGCATTTGCTAGAGGTCTTGCAACAGGTGTTATCGGCACTGCTGCAACAGTTGCTGGGGCAGTCTTTGCTGTTAAAAAAACAATCATTGATCCAGAAGAAAAAAAAGCAGCTTTCATTGAAGAAAACCGTAAAAAAGCTGCCCGCCGCCGTGTCACACGTTAA","11.70","9.22","6235","MAKKHAFARGLATGVIGTAATVAGAVFAVKKTIIDPEEKKAAFIEENRKKAARRRVTR","1405324","","conserved hypothetical protein","Cytoplasm, Extracellular","Limited matches in gapped BLAST to hypotheticals:residues 1-58 are 48% similar to gi|15674940| from S.pyogenes and residues 33-58 are 84% similar to gi|15900571| from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1214 (5e-09).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 12 09:52:41 2002","Tue Mar 12 09:52:41 2002","Tue Mar 12 09:52:41 2002","Tue Mar 12 09:52:41 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1345 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 12 09:52:41 2002","","No significant hits to the NCBI PDB database.","SMU.1479","","No significant hits to the Pfam 11.0 database","Tue Mar 12 09:52:41 2002","24379873","","","","","","1","","","SMU.1479","" "SMu1346","1405637","1406278","642","ATGGAAAATCGTAGATTGCAACCCAAGTATTCCCTAACAATCAAATGCTTATATATCGCACTACAAATAGCCAATTTAATACTTGTCTTTCTCACTTTAGTAACTTTATTTATTTCTTTTCCTTCTTTACGTGTACGTTTGTTCCCTTTTGCGATAGCTTTGATGACTGTCGTCTATCTATTTTTGAGAAATATTAATTACAAAATTTGTCGATTATTTGGCTACCATGCTTCACCAAAGTTGGTAGATTATGGACAGACAGTGTCTTATGATGGGATAACACTGCCGACTTTTGAAAAAATAACTGAAAACTATAAAGCAATCTATCAGACCAGACATGTTGGGTTTCAAAGTCTCTTTTATTTCTTTTTTATGGCGTTAAACGCTGGACTGATAGCTTTTTATGGCTTTCTTGCAGAACTAATCTTTCTTTACACAAAGATCAATACACAAACAGCAGTCTACATTTATGGACTAGGCGGTGCTGTTGCTATCTTTCTCATCATTTTTATCCAAATAAAGCTTAACAAAGGACTGCAAAAATACTTTGCCAAATGGTTTCACCTCAAAGTGATTTTAATGGAGCATGAACAGCCAATTTATTCCAAAAAAGTGCCACCCCAATTGAAGCCAGCCAGATAA","10.70","15.85","24802","MENRRLQPKYSLTIKCLYIALQIANLILVFLTLVTLFISFPSLRVRLFPFAIALMTVVYLFLRNINYKICRLFGYHASPKLVDYGQTVSYDGITLPTFEKITENYKAIYQTRHVGFQSLFYFFFMALNAGLIAFYGFLAELIFLYTKINTQTAVYIYGLGGAVAIFLIIFIQIKLNKGLQKYFAKWFHLKVILMEHEQPIYSKKVPPQLKPAR","1406287","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST found.SMu1346 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-36]?$	signal-peptide
tmhmm	$\"[21-41]?$ $\"[47-62]?$ $\"[119-139]?$ $\"[153-173]?$	transmembrane_regions

InterPro
IPR000073
Domain

Alpha/beta hydrolase fold-1
PF00561	$\"[138-201]T$	Abhydrolase_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[3-203]T$	G3DSA:3.40.50.1820
PTHR10992	$\"[3-204]T$	PTHR10992
PTHR10992:SF17	$\"[3-204]T$	PTHR10992:SF17
SSF53474	$\"[1-204]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-62 are 42% similar to a (HYDROLASE PROTEOME COMPLETE LIPASE) protein domain (PD034265) which is seen in Q9X561_ENTFC.Residues 145-203 are 28% similar to a (HYDROLASE PROTEOME COMPLETE ENOL-LACTONE) protein domain (PD000433) which is seen in O34312_BACSU.Residues 113-204 are 38% similar to a (DOMAIN OF UNKNO N) protein domain (PD311279) which is seen in Q9X561_ENTFC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 12 09:57:42 2002","Tue Mar 12 09:57:42 2002","Tue Mar 12 09:57:42 2002","Tue Mar 12 09:57:42 2002","","Tue Mar 12 09:57:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1347 is paralogously related (blast p-value < 1e-3) to SMu1220, a predicted alpha/beta superfamily hydrolases.","Tue Mar 12 09:57:42 2002","","No significant hits to the NCBI PDB database.","SMU.1482c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 09:57:42 2002","24379875","","","","","","1","","","SMU.1482c","" "SMu1348","1407421","1406966","456","ATGTACGGCGGAGCTGGTCTTTATAAATTTGATAAGTTGTCTGATTGGATGGTTTACCTAGACAGGCTCTCAAAGGATAAGCCAGTAGAAGAAGGGTGGACAGCAACGGTTTTTCTCTGCATTCGTCAGTCCGATAAGCGAATGATTGGTATTTGCAATGTCAGACATCATCTAAATAGTTTAGGTTTGCTTAATGTTTCAGGCCACATTGGTTATTCTATTCGGCCTGATGAGCGTAAGAAAGGCTACGCTAAAGTGCAGCTGCGCCTAGCATTGTTAGAAGCCAAGAAATTAGGCATTGACAAGGTTTTGGTGACCTGCGCAGACTGGAATATTGGTTCTGAACGTACTATCCTCGCAAACGGAGGTGTCTATGAAGACAGCCGTTTGGATGAATCAACGGGGAACATGATGAAGCGGTACTGGATAAATGTGACTGAAAGGAACAGCATATGA","9.70","5.57","17184","MYGGAGLYKFDKLSDWMVYLDRLSKDKPVEEGWTATVFLCIRQSDKRMIGICNVRHHLNSLGLLNVSGHIGYSIRPDERKKGYAKVQLRLALLEAKKLGIDKVLVTCADWNIGSERTILANGGVYEDSRLDESTGNMMKRYWINVTERNSI","1406981","","conserved hypothetical protein (possible acetyltransferase)","Cytoplasm","Some moderate matches in gapped BLAST to both hypothetical proteins and acetyltransferases; e.g. residues 3-143 are 43% similar to acetyltransferase, GNAT family, of Clostridium acetobutylicum (gi|15895752|); residues 15-145 are 42% similarto hypothetical protein of Streptococcus pneumoniae (gi|15902228|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2083 (3e-18).","

noIPR
unintegrated

unintegrated
SSF55729	$\"[33-126]T$	SSF55729

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 46-143 are 52% similar to a (PROTEOME COMPLETE VCA0631 PM0033) protein domain (PD338839) which is seen in Q9KFH6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 09:11:49 2002","Fri Jan 3 15:20:52 2003","Fri Jan 3 15:20:52 2003","Tue Mar 12 10:02:41 2002","","Tue Mar 12 10:02:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1348 is paralogously related (blast p-value < 1e-3) to SMu1880, a predicted conserved hypothetical protein; possible acetyltransferase.","Tue Mar 12 10:02:41 2002","","No significant hits to the NCBI PDB database.","SMU.1483c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 10:02:41 2002","24379876","","","","","","1","","","SMU.1483c","" "SMu1349","1408824","1407505","1320","ATGAGACTCACTGATAATTTCTCAGTTGCCAAATCTAAATTTGAAGCAGACTACCCTCAGTTATCAGAAAAATTGCTGGACAGGACTCTGGAAAATCTTTCCAAAGAGGATAATATCTTTATTTTTCCACATGATTTGCTGGAGTCTCCTGATTTGGAAAAAGATGGCAAGGTGTTGGAGACAGTAAGTGGTCAGATTAAAACGCAGAATATTATTGGTTTTCTGGGGTATGAAAATGAGCGTTTGACCATCCATTCTCGTTTTGCTAATGGGGACGATAACTATTTTTTGCATTATATGTTGCAAAAGGTGCTGCAGCTTAACCTAACCAGTCTGGATGTTGGTTTATCTCAGGAGGATAGTTGGTATCAGCTCTTGATTTATCTTTTTCCAAAGTATCTTCAGGCGGCTTTGCGCAAGGGACTTTACAAGGAATACCAGCGTTTTTTCTACAATGACAGCCATGTCAAAGGGACGATTGAGGTTGCTCGACATATTAAGAAAAATGTTCCTTTTACAGGGAAAATCACTTATTCGACTAGGGAATTTTCCTTTGATAATGCCCTCATGCAGCTGATTCGGCACACGATTGCCTTTATTCAGCATACTGTTCCAAATGGCAGAGCGCTTTTATCCAGTTCAGCATCTGTTAGGGAAAATACAGCTGAAATTGTGCGCGTGACACCGTCGTATAAGTTTTCAGATCGAGCGAAAATTATCCACCTTAACCAGACATGTCCCATACGTCATGCTTATTATTATGAATATGGCAAATTGCAGCAGCTTTGCTTGATGATTTTGCATCAAACAAAGCATGGGCTGAATCAATCCCAGCAAAAGATTCACGGCCTTCTCTTTGATGTCGCTTGGCTCTGGGAAGAATATCTGGCGACCTTGCTTGGAGAGGATTTTGAGCACCCGCAAAATAAGGTGAGTAAAGGTGGTATTTCTGTTTTCCAAAGTGGCAATGGTCGAAAAGTTTATCCAGACTTTTACAGCCGTCCGTTAGGTGTGGTCTTAGATGCTAAGTATAAAAAACTGGAAAAGGGTATTGCCAGAGAGGATTTGTTTCAGCTGATTACTTATTCTTATATTTCAAAGGCTCAGCTAGCTGGTTTGATATTTCCAAGTACGGGAAAAGAAATTGATAACGATATCGGAACTCTTGAAGGCTATGGCGGCATCTTGAAAAAATGGTCACTCTTAATTCCCCAAAAAAGCAGCAGCTATGATGATTTTGTCAAGCAAATTCAAGAATCGGAAAAAATATTTCAAGAAACTATTCAAAAACTCCTAAACGAAAGCGAGTGCACATTATGA","7.70","3.02","50639","MRLTDNFSVAKSKFEADYPQLSEKLLDRTLENLSKEDNIFIFPHDLLESPDLEKDGKVLETVSGQIKTQNIIGFLGYENERLTIHSRFANGDDNYFLHYMLQKVLQLNLTSLDVGLSQEDSWYQLLIYLFPKYLQAALRKGLYKEYQRFFYNDSHVKGTIEVARHIKKNVPFTGKITYSTREFSFDNALMQLIRHTIAFIQHTVPNGRALLSSSASVRENTAEIVRVTPSYKFSDRAKIIHLNQTCPIRHAYYYEYGKLQQLCLMILHQTKHGLNQSQQKIHGLLFDVAWLWEEYLATLLGEDFEHPQNKVSKGGISVFQSGNGRKVYPDFYSRPLGVVLDAKYKKLEKGIAREDLFQLITYSYISKAQLAGLIFPSTGKEIDNDIGTLEGYGGILKKWSLLIPQKSSSYDDFVKQIQESEKIFQETIQKLLNESECTL","1407520","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to hypotheticals and conserved hypotheticals: residues 1-430 are 62% similar to gi|15903172| from S.pneumoniae and residues 123-383 are 24% similar to gi|15791528| from Campylobacter jejuni SMu1349 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PD360097	$\"[123-362]T$	PD360097

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 123-363 are 24% similar to a (PROTEOME COMPLETE CJ0140 PLASMID) protein domain (PD360097) which is seen in Q9PIY7_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 09:10:56 2002","Tue Mar 12 10:29:16 2002","Tue Mar 12 10:29:16 2002","Tue Mar 12 10:29:16 2002","","Tue Mar 12 10:29:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1349 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 09:10:56 2002","","No significant hits to the NCBI PDB database.","SMU.1484c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 10:29:16 2002","24379877","","","","","","1","","","SMU.1484c","" "SMu1350","1410514","1408811","1704","ATGATGGAAGAAAATAGAAAATATTATTTTGTCGGTACAAAATTTGGAGAATATGACAACCTTGAACATTATAAAGAAGAAGGGAAATGGGAGCTAGGTTGGTATAATGATGAAGAAAATGCACAGTATCAAAAGATGCTTAAAGTGTTCAATAAAATAAAGTCTGGAGATATTTTATTAGCCAAGACATCATATACAAAAAAGAACAATTTGCCTTTTGAAAAAAAGAATGATATGACAGTTTCAGTGATGAAAATTCGTGGTATGGCAATTGTCAAAGAAGTTTTAGATGATAAACATACAGTAATTGTTGATTGGAAGGAAAATTATTCAGAACGAGAATGGTATTTCTTTACAGGTCAAGAGACTATCTGGGTACCTTCTAATATTAAAAATCGAGAAAAGGAAACATCGCAATTAATTGATTTTGCAACAAGTGAAAAAATAAAAGAGCAAAATTACGATTATTTTTTAAATCACCCATATTGGAATAAATATAAAAAAATTGAAACTGAGGAGAATCTTAAATTGCAAAATTATAAAGATATATTAAAAACTTCCAAAAACCTCATCCTCCGCGGTGCGCCGGGTACTGGAAAGACTTATCTGGCTAAGCAGATTGCTGAGGAACTGACTGACGGTAATGAAGACCAGATTGGCTTTGTTCAATTCCACCCGTCTTATGATTATACGGATTTTGTAGAAGGGTTGCGTCCTTCTTCGGGTGATGATGGTCAGATTGGTTTTAAGTTGCAGGATGGGATTTTTAGGGAGTTCTGTAAAAAAGCGAAAAAAGCTACTGAATCTGGTGGACAAGATAATTTTGATGAGGCTTGGGATAAATTCTTTGAAGCAGTGAACGATGTTGATCCTGATGGTTCTTATGATATTAAGACGTTAACGGGGAAACCAATGCACCTCATAGCATATATGCGTAATGAAATGTCTGGTGTCATGGAAAAAGGTTCTGCTAGTCTCTTTTATAATAAAGCACAATGTTATAATATTTATAAAGGTGATTCAGGTGTTCCAAAAGGGGGATTAGATAATTATCGTAAAGCTGTTGTTAAACACTTAAAAGAGAAATATGGTCTTGTCAATTATGTTAAACCAACTGAAACAACAACTGACAAAAAATTCGTCTTTATTATCGACGAAATCAACCGCGGGGAGATTTCCAAGATTTTTGGTGAACTGTTCTTCTCTATTGACCCAGACTATCGCGGGGAAAAGGGAGCCGTTTCAACGCAATATGCCAATTTACATGAAACGGATGAGAAATTTTATATCCCTGAAAATGTCTATATTATCGGCACCATGAACGATATTGACCGGTCTGTTGATACCTTTGATTTTGCCATGCGCCGTCGTTTCAGGTTTGTTGAGATAAAGGCAGCAGATACTATGGGAATGTGGGAAAATAATGACGAATTTGATAATGATAAAATTGAAGAAGCTAGAATCCGTTTGACAAATTTAAATAAGGCTATTTCAAATACAGAAGGGCTGAACAGTCATTATCATATTGGGCCATCTTATTTCTTGAAACTGAAAGATCTTGATTACGATTATGACATTCTTTGGTCTGATTACTTAGAGCCGCTTTTAAAAGATTATTTGCGCGGTTCCTATGATGAAACAGATAGTCTTGATAAATTAAAAGATGCTTATAATAATGAGGAAGAAACAGATGAGACTCACTGA","4.90","-21.60","66382","MMEENRKYYFVGTKFGEYDNLEHYKEEGKWELGWYNDEENAQYQKMLKVFNKIKSGDILLAKTSYTKKNNLPFEKKNDMTVSVMKIRGMAIVKEVLDDKHTVIVDWKENYSEREWYFFTGQETIWVPSNIKNREKETSQLIDFATSEKIKEQNYDYFLNHPYWNKYKKIETEENLKLQNYKDILKTSKNLILRGAPGTGKTYLAKQIAEELTDGNEDQIGFVQFHPSYDYTDFVEGLRPSSGDDGQIGFKLQDGIFREFCKKAKKATESGGQDNFDEAWDKFFEAVNDVDPDGSYDIKTLTGKPMHLIAYMRNEMSGVMEKGSASLFYNKAQCYNIYKGDSGVPKGGLDNYRKAVVKHLKEKYGLVNYVKPTETTTDKKFVFIIDEINRGEISKIFGELFFSIDPDYRGEKGAVSTQYANLHETDEKFYIPENVYIIGTMNDIDRSVDTFDFAMRRRFRFVEIKAADTMGMWENNDEFDNDKIEEARIRLTNLNKAISNTEGLNSHYHIGPSYFLKLKDLDYDYDILWSDYLEPLLKDYLRGSYDETDSLDKLKDAYNNEEETDETH","1408826","","conserved hypothetical protein (possible endonuclease)","Cytoplasm, Extracellular","Some moderate matches in gapped BLAST to both hypothetical proteins and endonuclease; e.g. residues 169-565 are 59% similar to hypothetical protein of S.pneumoniae (gi|15903173|); residues 41-463 are 27% similar to endonuclease of Campylobacter jejuni (gi|15791527|). SMu1350 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[186-467]T$	AAA

InterPro
IPR011704
Domain

ATPase associated with various cellular activities, AAA-5
PF07728	$\"[368-466]T$	AAA_5

noIPR
unintegrated

unintegrated
SSF52540	$\"[117-473]T$	SSF52540

","BeTs to 5 clades of COG1401COG name: McrB and related restriction endonucleasesFunctional Class: LThe phylogenetic pattern of COG1401 is --tk-q-ceb--uj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 367-505 are 26% similar to a (PROTEOME COMPLETE RESTRICTION COMPONENT) protein domain (PD006385) which is seen in Q9ZMQ4_HELPJ.Residues 189-258 are 37% similar to a (PROTEOME COMPLETE ENDONUCLEASE) protein domain (PD353925) which is seen in Q9RZI5_DEIRA.Residues 188-268 are 46% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in P96754_ECOLI.Residues 398-539 are 33% similar to a (ENDONUCLEASE RESTRICTION COMPLETE) protein domain (PD152463) which is seen in P96754_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 09:10:27 2002","Fri Jan 3 15:38:18 2003","Fri Jan 3 15:38:18 2003","Tue Mar 12 10:33:30 2002","","Tue Mar 12 10:33:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1350 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 09:10:27 2002","","No significant hits to the NCBI PDB database.","SMU.1485c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 10:33:30 2002","24379878","","","","","","1","","","SMU.1485c","" "SMu1351","1411255","1410521","735","ATGCGCGATAACCATTTACACACCCATTTTTCCTATGATTCTGACGCTAGCTTTGAGGACTACCTGACTCACTATGATGGGGAAATTGTCACGACTGAGCACTACGACCTGTCCAACCCCTACACTCAGCAGGATGATGTACCTGATTATGAGGCTTATTCTAAGGAAATAGCCGAGCTTAATGCGAAATACGGCAACCGCATCAAGCGAGGCATTGAAATTGGTTATTACCAGCCCCGTGAAGCGGACATTCTCAGCTTCCTAGCGGACAAGGACTATGATTTGAAATTACTCTCTGTCCATCACAACGGCGTCAATGATTATCTGGACGATGAAGTGGCAGATATGGACAAAGAGACCATTATCCAAGAATACTTAGACAAGCTGGAATACGCCATCGGACGCGTGGAAGCTGATGTACTGGCGCATTTCGACTATGGCTTTCGCTTGTTTGACCTGACGGTTGATGAATTAAAGACTCATGAAGCCCAGCTGCGCCGCATTTTCCACAAGATGATCGACCACAACCTAGCCTTTGAACTCAACAGCAAGTCCATGTACCTCTATGGACACGAGCATCTCTACCGCTATGCCTTAAGTCTAGTCAAAAACTTAGGCTGCCACAAATACACCATCGGCTCCGACGGTCACAAACTCGAACACTTCCGCCTAGCCTTTGACAAAATTCAAGACATCTTGGATGAGTATGGGATTGAAGAGGGGGAGATAATATAG","4.70","-22.17","28706","MRDNHLHTHFSYDSDASFEDYLTHYDGEIVTTEHYDLSNPYTQQDDVPDYEAYSKEIAELNAKYGNRIKRGIEIGYYQPREADILSFLADKDYDLKLLSVHHNGVNDYLDDEVADMDKETIIQEYLDKLEYAIGRVEADVLAHFDYGFRLFDLTVDELKTHEAQLRRIFHKMIDHNLAFELNSKSMYLYGHEHLYRYALSLVKNLGCHKYTIGSDGHKLEHFRLAFDKIQDILDEYGIEEGEII","1410536","","histidinol phosphatase","Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein:residues1-239 are 22% similar to gi15643567 from Thermotoga maritima.Residues 3-240 are 25% similar to gi401577 from Lactococcus lactis SMu1351 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR004013
Domain

PHP, C-terminal
PF02811	$\"[2-220]T$	PHP

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.140	$\"[1-244]T$	G3DSA:3.20.20.140
SSF89550	$\"[1-244]T$	SSF89550

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-239 are 22% similar to a (PROTEOME COMPLETE HISTIDINOL HISIE) protein domain (PD123927) which is seen in Q9WZR1_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 22 09:10:17 2002","Wed Jul 12 15:27:39 2006","Wed Jul 12 15:27:39 2006","Tue Mar 12 10:48:34 2002","","Tue Mar 12 10:48:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1351 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 22 09:10:17 2002","","No significant hits to the NCBI PDB database.","SMU.1486c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 10:48:34 2002","24379879","","","","","","1","","","SMU.1486c","817" "SMu1352","1411476","1412621","1146","ATGACACAATCAAAATTCCAACTAGTTGGATCTCTTCTTCGTCCAGCTGATCTGCTTGACTATAAAAATAAAATTGAACATCGTGATGACATTCAGTATCCTTTTTATGATAGTTTTCCGGGTTATCGTGAAACAGAAACAGCAGAGATTAAAAAGGTCATTGCTGATGAAAAGGCAAATGGTATTGATATTTTGACAGATGGTGAATATTCTAAGTCCATGTGGCATTTAGATTTTATTTGGGGACTTAAAGGTATTGAACGTTACATTGCAGACCACGGCTACACTTTTAAAGACCATGATGGCGGACAGTACGAAACACGTAAAGACATCGGTATTCGCATTACCCAGCCACTTTCAGGTAAAAATCATCATTTTTTAGATATTTACAAACTGCTCAAGGAAGAAGCTGGTGATACGCAAACAAAATTAACGATTTGGGGACCTGCGCATGCTTATACTGAACTGACTATCTTTGATAAACTTGCTGGTGAAGGGCAAGTTTACAAAACCAATGACGAATTAAAAGCTGGTCTTATCAAGGCCTACAAGGAATTTTTGACAGAATACAAGGAAGCTGGCGGTGAGATTATCCAGTTTGATGACTGCCTTTGGGAACTTTTTGATGAATCAAATCCTGCTTCGTTTTTTGCTGATGGCAATGCTGCGCTGGCTGATTTAGCTGATGAATTCATTGCGATCAATAACGAAGTAGCTGATTACGGTCATCAATTAGGACTCAAAGTTTGGACACATAACTGCCGCGGAAATTATGAAAGCCGTTCTGCCTCAGGCGGAACTTATGAAGCGATTGCGGAAAAATTCTTGCGTGATCAACACTATGACCGCTTCTTCTTAGAATGGGACAGCGACGTCTCAGGTGATTTGAAGGCTCTTGCTTCTCTTAAAGATAAAGATGCTGAGGTTGTTCTTGGACTCCTTTCCAGTAAGACAACTGATCTTGATGATGAAGAACGTGTTCTCAAGTTATTAGAACAAGCCAGCACCATTTTGCCTAAGGAACGTTTGCTGCTGTCACATCAATGCGGTTTTGCCTCTTGTGATTCTGGCAATGAGTTGGCTATCCCGCAGCAATGGGCTAAAATCAAACAAGGCCAAGAAATCGCTAAGAAATTTTGGGGTTAA","4.70","-20.50","43257","MTQSKFQLVGSLLRPADLLDYKNKIEHRDDIQYPFYDSFPGYRETETAEIKKVIADEKANGIDILTDGEYSKSMWHLDFIWGLKGIERYIADHGYTFKDHDGGQYETRKDIGIRITQPLSGKNHHFLDIYKLLKEEAGDTQTKLTIWGPAHAYTELTIFDKLAGEGQVYKTNDELKAGLIKAYKEFLTEYKEAGGEIIQFDDCLWELFDESNPASFFADGNAALADLADEFIAINNEVADYGHQLGLKVWTHNCRGNYESRSASGGTYEAIAEKFLRDQHYDRFFLEWDSDVSGDLKALASLKDKDAEVVLGLLSSKTTDLDDEERVLKLLEQASTILPKERLLLSHQCGFASCDSGNELAIPQQWAKIKQGQEIAKKFWG","1412630","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical protein: residues 3-380 are 31% similar to gi|15618067| from Chlamydophila pneumoniae and residues 6-380 are 32% similar to gi|15672700| from Lactococcus lactis.SMu1352 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.210	$\"[5-380]T$	G3DSA:3.20.20.210
SSF51726	$\"[6-381]T$	SSF51726

","BeTs to 3 clades of COG0620COG name: Methionine synthase II (cobalamin-independent)Functional Class: EThe phylogenetic pattern of COG0620 is amtKyqv-eBrh-------N-Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 43-327 are 34% similar to a (PROTEOME COMPLETE KATB PEPT-KATB) protein domain (PD041263) which is seen in YXJH_BACSU.Residues 331-380 are 52% similar to a (PROTEOME COMPLETE YHCE) protein domain (PD191511) which is seen in Q9Z940_CHLPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:45:39 2002","Tue Mar 12 10:52:43 2002","Tue Mar 12 10:52:43 2002","Tue Mar 12 10:52:43 2002","","Tue Mar 12 10:52:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1352 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:45:39 2002","","No significant hits to the NCBI PDB database.","SMU.1487","","No significant hits to the Pfam 11.0 database","Tue Mar 12 10:52:43 2002","24379880","","","","","","1","","","SMU.1487","" "SMu1353","1413085","1412816","270","ATGATGACTTCTCTTAAAAAAATAGCTAAAAACGCCATCTCATCAGCCTTTGAGATAGTCTATATCCTGACCTTCACCAATCAAAAAGATGTTCCGAATATGACAGAAGAAATCAAGCGATTGGGTAAGTGGTATGTCAATACTGGTGATGAATGGATTTGTCATTCAAATCTACCTTTATCCGAATTTCAAGAGAAATTTTTGGAGCTGACACATCTGACTTCTGAGCAAGTGTTCTTGACTAAAGATCATCTGCCATTTTCAAAATAA","6.80","-0.34","10378","MMTSLKKIAKNAISSAFEIVYILTFTNQKDVPNMTEEIKRLGKWYVNTGDEWICHSNLPLSEFQEKFLELTHLTSEQVFLTKDHLPFSK","1412831","","conserved hypothetical protein","Cytoplasm","Only matches in gapped BLAST to hypothetical protein:residues 38-89 are 43% similar to gi|15901048| from S.pneumoniaeSMu1353 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:44:56 2002","Tue Mar 12 10:54:56 2002","Tue Mar 12 10:54:56 2002","Tue Mar 12 10:54:56 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1353 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:44:56 2002","","No significant hits to the NCBI PDB database.","SMU.1488c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 10:54:56 2002","24379881","","","","","","1","","","SMU.1488c","" "SMu1354","1414001","1413105","897","ATGGTTATTGAATTAAAAAATGAAAAAGTAACTGTCCAGTTTAAAGAGTTTGGCGGTGCTTTGTCTTCTATCAAAGATCAAGATGGTATAGAATACCTATGGCAGGGAAATCCTGCCTACTGGAGTTCTCAGGCACCGGTTCTTTTTCCTATTTGCGGCAGTTTAAGAAATGATAAGGGCATTTACACGTCTAAGAAACACTCACATCGTTATGGTAGCATCCCTAGACACGGCCTGGTGCGAAAGAAAAATTTTCGCTTTGAGCAACTGGGAAAAGACAGTGTTGTTTTTACCATTACTCCTGACAAAGAAATGCTGATGCAATATCCCTATCATTTTGAATTAAAGATTATCTACACTTTAAAGCATACAACTATTCGCACAGAGTATCAGGTTATTAACAAAGAAAAAGAAAGCATCATGCCTTATTTTATCGGAGGCCATCCCGGTTTGAACTGTCCCTTGTTTGCAGGAGATCGCTATGAAGACTACTATCTTGAATTTGAAAAGGAAGAAACCTGTACAGTACCAAAATCTTTTCCTGATACAGGGTTGCTTGATTTACAAGACAGAAAAATTTTCTTGAAAGGGCAGAAATACCTTGATTTGGATTATTCTTTGTTTACGCATGACGCCATTACTTTAGATAATCTACAATCAAGAAGTGTCAGTCTGCGTTCTAAAAATCACGGCGGAGGCCTGCGTTTGGATTTTGCAGATTTTCCTTACCTTATTCTTTGGTCAACAGCCAATAAGAGTCCTTTTATAGCCTTAGAACCTTGGAGCGGGTTGTCAACTGCGGTAGATGAATCAGATTATTTTGAAGAAAAACGCAATGTGAGCTTTGTAGAGCCCGGACAGTTTGATCGAAACTATTTTGACATCACTGTTTTATAA","6.50","-2.20","34515","MVIELKNEKVTVQFKEFGGALSSIKDQDGIEYLWQGNPAYWSSQAPVLFPICGSLRNDKGIYTSKKHSHRYGSIPRHGLVRKKNFRFEQLGKDSVVFTITPDKEMLMQYPYHFELKIIYTLKHTTIRTEYQVINKEKESIMPYFIGGHPGLNCPLFAGDRYEDYYLEFEKEETCTVPKSFPDTGLLDLQDRKIFLKGQKYLDLDYSLFTHDAITLDNLQSRSVSLRSKNHGGGLRLDFADFPYLILWSTANKSPFIALEPWSGLSTAVDESDYFEEKRNVSFVEPGQFDRNYFDITVL","1413120","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1355 (lacG); SMu1356 (lacE); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). ","aldose 1-epimerase ","Cytoplasm, Extracellular","Limited matches in gapped BLAST to lacX protein: residues 1-298 are 61% similar to gi125940 from Lactococcus lactis and residues 2-297 are 31% similar to gi16803323 from Listeria monocytogenes EGD-eThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1927 (5e-93).","

InterPro
IPR008183
Family

Aldose 1-epimerase
PF01263	$\"[1-263]T$	Aldose_epim

InterPro
IPR011013
Domain

Glycoside hydrolase-type carbohydrate-binding
SSF74650	$\"[3-297]T$	Gal_mut_like

InterPro
IPR014718
Domain

Glycoside hydrolase-type carbohydrate-binding, subgroup
G3DSA:2.70.98.10	$\"[2-176]T$	Glyco_hydro_42_D5

noIPR
unintegrated

unintegrated
PTHR11122	$\"[17-261]T$	PTHR11122

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 117-297 are 63% similar to a (PLASMID LACX PROTEIN LACX-LIKE) protein domain (PD040183) which is seen in LAXC_LACLA.Residues 117-243 are 33% similar to a (PROTEOME COMPLETE YTJH YQHA) protein domain (PD415223) which is seen in Q9CEC2_LACLA.Residues 1-116 are 58% similar to a (PROTEOME COMPLETE LACX PLASMID) protein domain (PD024258) which is seen in LAXP_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 13 12:24:58 2007","Tue Mar 13 12:17:13 2007","Tue Mar 13 12:17:13 2007","Tue Mar 12 10:59:02 2002","","Tue Mar 12 10:59:02 2002","yes","Thu Oct 17 16:29:10 2002","SMu1354 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 12 11:00:17 2002","","No significant hits to the NCBI PDB database.","SMU.1489c","","Residues 2 to 281 (E-value = 2.5e-18) place SMu1354 in the Aldose_epim family which is described as Aldose 1-epimerase (PF01263)","Tue Mar 12 10:59:02 2002","","","","de Vos,W.M., Boerrigter,I., van Rooyen,R.J., Reiche,B. andHengstenberg,W.Characterization of the lactose-specific enzymes of thephosphotransferase system in Lactococcus lactisJ. Biol. Chem. 265 (36), 22554-22560 (1990)PubMed: 2125052","","Tue Mar 12 11:00:17 2002","1","","","SMU.1489c","" "SMu1355","1415654","1414248","1407","ATGAGCAAAACATTACCTAAAGATTTTATCTTTGGTGGTGCAACAGCAGCTTATCAGGCTGAAGGTGCCACTCATGCAGATGGGAAGGGTCCTGTTGCTTGGGATAAATATTTAGAAGATAACTACTGGTATACAGCTGAACCTGCCAGCGATTTCTATCATCAATATCCTGTTGATTTAAAGTTGGCAGAAGAATTTGGCGTCAACGGTATTCGCATTTCCATTGCTTGGTCACGGATTTTTCCAAAAGGGTATGGAGCCGTTAACCCCAAAGGTCTTGCCTTTTATCATAATCTTTTTGCTGAATGCCATAAACGTCATGTGGAACCTTTTGTAACACTTCATCACTTTGATACCCCAGAGGCTTTGCATTCAAATGGTGACTTTCTCAATCGTGAAAATATAGAGCATTTTGTCAACTATGCTGAATTTTGCTTTAAAGAATTTCCAGAAGTGAATTATTGGACAACTTTCAATGAAATTGGCCCCATTGGTGATGGTCAGTATCTGGTTGGAAAATTTCCGCCAGGCATCCAATACGATCTTGCCAAGGTTTTCCAATCCCACCACAACATGATGGTTGCACATAGCAAGGCAGTCAAACTTTTCAAAGATGGTGGCTACTCTGGCGAAATTGGTGTGGTTCATGCTCTGCCAACCAAATATCCTTATGATCCAAACAACCCAGCAGATATTCGTGCGGCAGAATTAGAAGATATTATTCATAATAAATTCATCTTGGATGCGACTTATCTGGGTAAGTATTCTGAGAAAACTATGGAAGGGGTCAATCATATTTTGGCTGTCAATGGTGGTCAATTAGACCTTCGTGAGGAAGATTTTGCTGCTCTTGAAGCTGCTAAAGATCTCAATGATTTCTTGGGTATCAATTATTATATGAGTGATTGGATGCGTGCTTTTGATGGTGAAACCGAAATTACGCATAATGCTAAAGGCGAAAAAGGAAGTTCTAAGTACCAGATTAAGGGTGTCGGTCGCAGAGAAGCGCCAGTAAATGTTCCCAAAACAGATTGGGATTGGATCATTTATCCGCAAGGACTTTACGACCAAATCATGCGAGTTAAGCAGGACTATCCTAATTACAAGAAGATTTATATCACTGAAAATGGTCTTGGTTATAAGGATGAATTTGTGAATCATACTGTTTATGATGATGCCCGTATTGATTATGTTAAAAAACACTTAGAAGTTCTTTCAGATGCTATAGCAGACGGTGCCAATGTCAAAGGTTACTTTATCTGGTCTCTGATGGATGTCTTCTCATGGTCAAATGGTTATGAGAAGCGCTATGGTCTCTTTTATGTTGATTTTGATACGCAAGAGCGTTATCCCAAGAAAAGTGCCTACTGGTATAAAAAGTTAGCTGAGACCCAAATAATTGACTGA","5.60","-13.72","53751","MSKTLPKDFIFGGATAAYQAEGATHADGKGPVAWDKYLEDNYWYTAEPASDFYHQYPVDLKLAEEFGVNGIRISIAWSRIFPKGYGAVNPKGLAFYHNLFAECHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVNYAEFCFKEFPEVNYWTTFNEIGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVAHSKAVKLFKDGGYSGEIGVVHALPTKYPYDPNNPADIRAAELEDIIHNKFILDATYLGKYSEKTMEGVNHILAVNGGQLDLREEDFAALEAAKDLNDFLGINYYMSDWMRAFDGETEITHNAKGEKGSSKYQIKGVGRREAPVNVPKTDWDWIIYPQGLYDQIMRVKQDYPNYKKIYITENGLGYKDEFVNHTVYDDARIDYVKKHLEVLSDAIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFDTQERYPKKSAYWYKKLAETQIID","1414263","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1354 (lacX); SMu1356 (lacE); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). ","phospho-beta-D-galactosidase","Cytoplasm, Extracellular","Matches in gapped BLAST to phospho-beta-galactosidase:residues 1-468 are 99% similar to the previously published enzyme in S.mutans (gi|433810|) and (gi|1730084|).Residues 1-468 are 90% similar to the enzyme from S.pyogenes(gi|15675725|) and are 89% similar to phospho-B-galactosidase from S.gordonii (gi|11611665|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1103 (3e-61).","

InterPro
IPR001360
Family

Glycoside hydrolase, family 1
PR00131	$\"[290-304]T$ $\"[371-379]T$ $\"[391-402]T$ $\"[412-429]T$ $\"[436-448]T$	GLHYDRLASE1
PTHR10353	$\"[4-468]T$	Glyco_hydro_1
PF00232	$\"[1-467]T$	Glyco_hydro_1
PS00572	$\"[371-379]T$	GLYCOSYL_HYDROL_F1_1
PS00653	$\"[9-23]T$	GLYCOSYL_HYDROL_F1_2

InterPro
IPR005928
Family

6-phospho-beta-galactosidase
TIGR01233	$\"[2-468]T$	lacG

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[1-468]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
SSF51445	$\"[1-468]T$	SSF51445

","No hits to the COGs database.","***** IPB001360 (Glycoside hydrolase family 1) with a combined E-value of 9.1e-63. IPB001360A 5-23 IPB001360B 51-84 IPB001360C 245-256 IPB001360D 292-301 IPB001360E 411-438","Residues 1-63 are 77% similar to a (6-PHOSPHO-BETA-GALACTOSIDASE) protein domain (PD386103) which is seen in LACG_LACAC.Residues 49-84 are 58% similar to a (BETA-GLUCOSIDASE HYDROLASE AMYGDALASE) protein domain (PD235643) which is seen in O50658_BBBBB.Residues 351-458 are 30% similar to a (BETA-GLUCOSIDASE-LIKE) protein domain (PD395977) which is seen in Q9LZJ0_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:28:31 2002","Tue Mar 12 11:15:58 2002","Thu Oct 17 16:28:31 2002","Tue Mar 12 11:15:58 2002","Tue Mar 12 11:15:58 2002","Tue Mar 12 11:15:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1355 is paralogously related (blast p-value < 1e-3) to SMu1007, SMu1456, and SMu0895, all predicted beta-glucosidases.","Tue Mar 12 11:25:30 2002","Tue Mar 12 11:15:58 2002","pdb|3PBG|A Chain A, 6-Phospho-Beta-Galactosidase Form-C >gi|239... 920 0.0pdb|2PBG| 6-Phospho-Beta-D-Galactosidase Form-B 918 0.0pdb|4PBG|A Chain A, 6-Phospho-Beta-Galactosidase Form-Cst >gi|2... 916 0.0","SMU.1490c","","Residues 1 to 467 (E-value = 3.8e-243) place SMu1355 in the Glyco_hydro_1 family which is described as Glycosyl hydrolase family 1 (PF00232)","Tue Mar 12 11:15:58 2002","","","Honeyman,A.L. and Curtiss,R. III.Isolation, characterization and nucleotide sequence of theStreptococcus mutans lactose-specific enzyme II (lacE) gene of thePTS and the phospho-beta-galactosidase (lacG) geneJ. Gen. Microbiol. 139 (Pt 11), 2685-2694 (1993)PubMed: 8277252Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164Cote CK, Cvitkovitch D, Bleiweis AS, Honeyman ALA novel beta-glucoside-specific PTS locus from Streptococcus mutans that is not inhibited by glucose.Microbiology 2000 Jul;146 ( Pt 7):1555-63 PubMed: 10878120PMID: 10878120","Boizet,B., Villeval,D., Slos,P., Novel,M.,Novel,G.and Mercenier,A.Isolation and structural analysis of the phospho-beta- galactosidase gene from Streptococcus lactis Z268Gene 62 (2), 249-261 (1988)PubMed: 3130294De Vos,W.M. and Gasson,M.J.Structure and expression of the Lactococcus lactis gene forphospho-beta-galactosidase (lacG) in E.coli and L.lactisJ. Gen. Microbiol. 135 (Pt 7), 1833-1846 (1989)PubMed: 2515252","Tue Apr 2 18:12:37 2002","Tue Mar 12 11:24:35 2002","1","","","SMU.1490c","" "SMu1356","1417372","1415666","1707","ATGAACACATTGATTGCTCAAATTGAAAAGGGAAAGCCTTTCTTTGAAAAAATTTCGCGTAATATTTATCTACGTGCTATTCGTGATGGGTTTATCTCGGCAATGCCGGTCATCCTATTTTCGAGTATTTTTCTGTTGATCGCTTATGTTCCTAATATCTTTGGTTTTACTTGGCCAAAAGGTATTGAAAACATGTTGATGACACCCTATAACTATACGATGGGGATTATTGGTTTCCTAGTGGCTGGTACAACTGCTAAATCACTAACGGATTCGATGAACCGCCAATTAGAAAAGACCAACCAGATTAATTTCATTTCAACAATGTTAGCTTCTATGGCCGGTTTTTTAATCATGGCAGCGGATCCAGCTAAAGAAGGTGGTTTCTTGAGTGCCTTTATGGGAACTAAGGGCTTGTTAACTGCTTTCATTGCAGCCTTTATTACTGTTAATGTCTACAAGATTTGTGTTAAAAATAATGTTACCATTCGTATGCCTGAGGAGGTACCGCCAAATATCTCTCAAGTGTTTAAAGATATTTTTCCATTTGCCTTTTCCATTATTATTTTGTATGCTATCCAATTAGCTATTAAGGCAGTTATTGGAGTAAATGTGGCTCAGTCAATTGGAACCTTGCTTGCTCCTTTATTTTCAGCAGCCGATGGCTATCTTGGTATTACGATTATTTTTGGAGCTTACGCCTTGTTCTGGTTTGTCGGTATTCATGGTCCTTCTATTGTTGAGCCGGCTATTGCAGCCATTACATATTCAAATGTTGAATTGAATGCACATTTGATTCATGCTGGTCAACATGCTGATAAAGTGATTACCTCAGGAACTCAGATGTTTATTGTAACTATGGGTGGTACTGGTGCAACATTAGTTGTTCCTTTCATGTTCATGTGGTTATGTAAATCAAAACGCAATAAGGCTATTGGACGTGCTTCTGTTGTGCCAACTTTCTTTGGCGTCAATGAACCTATCTTGTTTGGAGCACCTATTGTTTTAAATCCAGTCTTTTTCATCCCTTTCATTCTTGCCCCAATTGTTAATGTTTGGATTTTTAAGTTTTTTGTTGATACCCTTGGAATGAACAGTTTCTTTGCTAATCTTCCATGGACAACACCCGGGCCAATAGGCATTGTCTTAGGAACTGGATTTGCTGTTTTATCTTTTGTTCTTGCAGCACTTTTAATCCTTGTAGATACTGTCATTTATTATCCTTTTGTTAAAGTTTATGATGAACAGATTTTGGCTGAAGAAGCTGAAGGTAAAAGTTCATCCGATGCTTTAAAAGAAAAAGTAGCAGCTAACTTTGATACGAAAAAAGCTGATGCTATTCTTGAAGGTGCTGAATCTAAAGAAGAGCCAGCAACTCATGCTATTACTGAAGAAACAAATGTTCTCGTTTTATGTGCCGGCGGCGGTACCAGCGGTCTTTTAGCTAATGCTTTAAATAAAGCCGCAGAAGAATACGGAGCCCCTGTTAAGGCTGCAGCTGGAAGTTATGGCGCTCACCGCGAAATTTTAGACCAATACCAATTAGTCATCTTGGCTCCGCAAGTTGCTTCTAACTATGAAGATATGAAGGCAGAAACGGATAAACTTGGCATCAAATTAGCTAAGACCGAAGGTGCTCAATATATTGGTTTGACGCGTGATGGCAAGGGAGCGCTTGCCTTTGTGGAAGAACAATTTAAAGATTGA","6.00","-3.67","61411","MNTLIAQIEKGKPFFEKISRNIYLRAIRDGFISAMPVILFSSIFLLIAYVPNIFGFTWPKGIENMLMTPYNYTMGIIGFLVAGTTAKSLTDSMNRQLEKTNQINFISTMLASMAGFLIMAADPAKEGGFLSAFMGTKGLLTAFIAAFITVNVYKICVKNNVTIRMPEEVPPNISQVFKDIFPFAFSIIILYAIQLAIKAVIGVNVAQSIGTLLAPLFSAADGYLGITIIFGAYALFWFVGIHGPSIVEPAIAAITYSNVELNAHLIHAGQHADKVITSGTQMFIVTMGGTGATLVVPFMFMWLCKSKRNKAIGRASVVPTFFGVNEPILFGAPIVLNPVFFIPFILAPIVNVWIFKFFVDTLGMNSFFANLPWTTPGPIGIVLGTGFAVLSFVLAALLILVDTVIYYPFVKVYDEQILAEEAEGKSSSDALKEKVAANFDTKKADAILEGAESKEEPATHAITEETNVLVLCAGGGTSGLLANALNKAAEEYGAPVKAAAGSYGAHREILDQYQLVILAPQVASNYEDMKAETDKLGIKLAKTEGAQYIGLTRDGKGALAFVEEQFKD","1415681","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1354 (lacX); SMu1355 (lacG); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). ","PTS system, lactose-specific component IIBC","Membrane, Cytoplasm","Matches in gapped BLAST to PTS system, lactose-specific component IIBC:residues 1-568 are 95% similar to the previously published protein in S.mutans (gi|1709898|). Residues 1-568 are 78% similar to the enzyme from S.pyogenes(gi|15675726|).Residues 1-566 are 76% similar to the enzyme fromLactococcus lactis (gi|131496|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0330 (3e-40).","

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[28-348]T$	PTS_EIIC

InterPro
IPR003501
Domain

Phosphotransferase system, lactose/cellobiose-specific IIB subunit
PF02302	$\"[467-564]T$	PTS_IIB

InterPro
IPR004501
Domain

Phosphotransferase system, lactose/cellobiose IIC component
TIGR00410	$\"[13-423]T$	lacE
PS51105	$\"[8-409]T$	PTS_EIIC_TYPE_3

InterPro
IPR004801
Domain

Phosphotransferase system, lactose-specific IIC component
TIGR00394	$\"[7-423]T$	lac_pts_IIC

InterPro
IPR013012
Domain

Phosphotransferase system, EIIB component, type 3
PS51100	$\"[465-568]T$	PTS_EIIB_TYPE_3

InterPro
IPR014350
Domain

Phosphotransferase system, EIIB component, type 3, subgroup
TIGR00853	$\"[421-561]T$	pts-lac

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.270	$\"[463-566]T$	G3DSA:3.40.50.270
SSF52794	$\"[465-568]T$	SSF52794

","BeTs to 3 clades of COG1455COG name: Phosphotransferase system cellobiose-specific component IICFunctional Class: GThe phylogenetic pattern of COG1455 is --------eB------o----Number of proteins in this genome belonging to this COG is 2","***** IPB003501 (Lactose/Cellobiose specific IIB subunit) with a combined E-value of 8.7e-27. IPB003501A 469-490 IPB003501B 514-540","Residues 144-428 are 95% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD006461) which is seen in PTLB_STRMU.Residues 1-142 are identical to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD186359) which is seen in PTLB_STRMU.Residues 429-566 are 92% similar to a (COMPONENT SYSTEM IIBC PHOSPHOTRANSFERASE) protein domain (PD014402) which is seen in PTLB_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Nov 5 08:49:47 2002","Tue Mar 12 11:29:45 2002","Thu Oct 17 16:27:59 2002","Tue Mar 12 11:29:45 2002","Tue Mar 12 11:29:45 2002","Tue Mar 12 11:29:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1356 is paralogously related (blast p-value < 1e-3) to SMu1451, a predicted PTS system component and SMu0159, a predicted hypothetical protein (possible PTS system component).","Tue Mar 12 11:29:45 2002","","No significant hits to the NCBI PDB database.","SMU.1491c","","Residues 28 to 348 (E-value = 9e-102) place SMu1356 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)Residues 467 to 564 (E-value = 1.2e-30) place SMu1356 in the PTS_IIB family which is described as PTS system, Lactose/Cellobiose specific IIB subunit (PF02302)","Tue Mar 12 11:29:45 2002","","","Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164Honeyman,A.L. and Curtiss,R. III.Isolation, characterization and nucleotide sequence of theStreptococcus mutans lactose-specific enzyme II (lacE) gene of thePTS and the phospho-beta-galactosidase (lacG) geneJ. Gen. Microbiol. 139 (Pt 11), 2685-2694 (1993)PubMed: 8277252","de Vos,W.M.,Boerrigter,I.,van Rooyen,R.J.,Reiche,B.and Hengstenberg,W.Characterization of the lactose-specific enzymes of thephosphotransferase system in Lactococcus lactisJ. Biol. Chem. 265 (36), 22554-22560 (1990)PubMed: 2125052","Tue Mar 12 11:36:03 2002","Tue Mar 12 11:34:57 2002","1","","","SMU.1491c","" "SMu1357","1417693","1417379","315","ATGAACAGAGAAGAAGCGACTCTTTTGGGGTTTGAAATTGTAGCCTATGCAGGAGATGCACGTTCTAAATTACTTGAAGCTTTGAATGCGGCACAGGCCGGTGAGTACGATAGGGCAGAAGAGCTTGTAGCTGCGGCAGATGACTGTATTGTTGATGCCCATAAAGCTCAAACAAGCCTTTTGGCTAAGGAAGCACAAGGTGATGATATTGAACTTAGTGTTACTTTAATGCACGGACAAGATCACCTGATGACAACCATACTTCTAAAAGATTTGATGAAACATTTAATTGAATTGTACAAAAGAGGGAGCTAA","4.60","-8.09","11382","MNREEATLLGFEIVAYAGDARSKLLEALNAAQAGEYDRAEELVAAADDCIVDAHKAQTSLLAKEAQGDDIELSVTLMHGQDHLMTTILLKDLMKHLIELYKRGS","1417394","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1354 (lacX); SMu1355 (lacG); SMu1356 (lacE);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). ","PTS system, cellobiose-specific IIA component","Cytoplasm","Matches in gapped BLAST to phosphotransferase system enzyme II:residues 1-104 are 100% similar to the previously published protein in S.mutans (gi131519),(gi322124) and (gi153677). Residues 1-104 are 79% similar to the enzyme from S.pyogenes (gi15675727).Residues 1-103 are 76% similar to the enzyme from S.pneumoniae (gi15903114). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0328 (6e-14).","

InterPro
IPR003188
Family

Phosphotransferase system, lactose/cellobiose-specific IIA subunit
PD007286	$\"[9-100]T$	Ptrans_IIA
G3DSA:1.20.58.80	$\"[1-102]T$	PTS_IIA_lac
PIRSF000699	$\"[4-104]T$	PTS_IILac_III
PF02255	$\"[7-102]T$	PTS_IIA
TIGR00823	$\"[4-102]T$	EIIA-LAC
PS51095	$\"[4-102]T$	PTS_EIIA_TYPE_3
SSF46973	$\"[1-102]T$	Ptrans_IIA

","BeTs to 3 clades of COG1447COG name: Phosphotransferase system cellobiose-specific component IIAFunctional Class: GThe phylogenetic pattern of COG1447 is --------eB------o----Number of proteins in this genome belonging to this COG is 2","***** IPB003188 (PTS system, Lactose/Cellobiose specific IIA subunit) with a combined E-value of 1.4e-49. IPB003188A 4-39 IPB003188B 50-91","Residues 1-103 are identical to a (COMPONENT SYSTEM IIA PHOSPHOTRANSFERASE) protein domain (PD007286) which is seen in PTLA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 10:12:15 2006","Thu Sep 28 10:12:15 2006","Thu Sep 28 10:12:15 2006","Tue Mar 12 13:07:58 2002","Tue Mar 12 13:07:58 2002","Tue Mar 12 13:07:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1357 is paralogously related (blast p-value < 1e-3) to SMu1453, a predicted phosphotransferase system sugar-specific EII component.","Tue Mar 12 13:16:44 2002","Thu Sep 28 10:12:15 2006","pdb1E2AA Chain A, Enzyme Iia From The Lactose Specific Pts Fr... 151 2e-038","SMU.1492c","","Residues 7 to 102 (E-value = 3.4e-59) place SMu1357 in the PTS_IIA family which is described as PTS system, Lactose/Cellobiose specific IIA subunit (PF02255)","Tue Mar 12 13:07:58 2002","","","Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164","Breidt,F. Jr., Hengstenberg,W., Finkeldei,U. and Stewart,G.C.Identification of the genes for the lactose-specific components ofthe phosphotransferase system in the lac operon of StaphylococcusaureusJ. Biol. Chem. 262 (34), 16444-16449 (1987)PubMed: 2824493Stuber,K., Deutscher,J., Sobek,H.M., Hengstenberg,W. andBeyreuther,K.Amino acid sequence of the amphiphilic phosphocarrier proteinfactor IIILac of the lactose-specific phosphotransferase system ofStaphylococcusBiochemistry 24 (5), 1164-1168 (1985)PubMed: 4096897de Vos,W.M., Boerrigter,I., van Rooyen,R.J., Reiche,B. andHengstenberg,W.Characterization of the lactose-specific enzymes of thephosphotransferase system in Lactococcus lactisJ. Biol. Chem. 265 (36), 22554-22560 (1990)PubMed: 2125052","Tue Mar 12 13:12:54 2002","Tue Mar 12 13:15:30 2002","1","","","SMU.1492c","" "SMu1358","1418686","1417709","978","ATGACATTAACACAAGAAAAGCGCAGTTATATGGAAAAACTTAGTGATGAAAATGGAATTATTTCAGCTTTAGCTTTTGACCAGCGTGGTGCTTTAAAACGCTTGATGGCGCAGTATCAAACGCAAGAACCAACGATTGCTCAAATGGAAGAGCTGAAGGTCTTAGTAGCAGAAGAATTAACACCTTATGCTTCATCCATGCTGCTTGATCCAGAATATGGTCTTCCAGCAGCAAAACATTTGGATAAAAATGCAGGTTTGCTCCTTGCTTATGAGAAGACTGGTTATGATACAACAAGCACTAAACGCTTGCCAGATTGTCTGGTTGAATGGTCAGCCAAACGTTTGAAAAAACAAGGTGCAGATGCTGTTAAATTCTTGCTCTATTATGATGTTGATGGTGATGAAGAAGTTAACCAGCAAAAACAGGCTTATATTGAACGAATTGGTTCTGAATGTAAGGCAGAAGATATTCCCTTTTTCCTTGAAATTTTAGCTTATGACGAAACCATTACTGATGCCGCAAGCGTTGAGTATGCTAAAGTAAAGCCTCATAAAGTGCTTGATGCTATGAAAGTCTTCTCAGACGAGCGTTTTGGCATTGATGTTCTGAAGGTTGAGGTTCCTGTTAACATGAAGTATGTCGAAGGTTTTGGTGATGGCCCAATTGTTCACACTCAAGATCAAGCAGCAAACTTCTTTAAACAACAAGATCAAGCAACACCGCTTCCCTATATTTATTTGAGTGCAGGTGTTTCTGCTAAGTTATTCCAAGATACGCTTGTTTTTGCAAAAGAGTCAGGGGCTAATTTTAACGGTGTCCTTTGCGGACGTGCCACATGGGCTGGTTCAGTTAAAGATTATATTGAAAAAGGCGAAGCAGCAGCCCGCCAGTGGCTTCGTACAGAAGGATTCAAGAATATTGATGAGCTGAATAAGGTTTTAAAAGCAACCGCAACGTCTTGGAAAGAAAGATAG","4.90","-9.39","36477","MTLTQEKRSYMEKLSDENGIISALAFDQRGALKRLMAQYQTQEPTIAQMEELKVLVAEELTPYASSMLLDPEYGLPAAKHLDKNAGLLLAYEKTGYDTTSTKRLPDCLVEWSAKRLKKQGADAVKFLLYYDVDGDEEVNQQKQAYIERIGSECKAEDIPFFLEILAYDETITDAASVEYAKVKPHKVLDAMKVFSDERFGIDVLKVEVPVNMKYVEGFGDGPIVHTQDQAANFFKQQDQATPLPYIYLSAGVSAKLFQDTLVFAKESGANFNGVLCGRATWAGSVKDYIEKGEAAARQWLRTEGFKNIDELNKVLKATATSWKER","1417724","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1354 (lacX); SMu1355 (lacG); SMu1356 (lacE);SMu1357 (lacF);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). ","tagatose-1,6-bisphosphate aldolase","Cytoplasm","Matches in gapped BLAST to tagatose-1,6-bisphosphate aldolase :residues 1-325 are 99% similar to the previously published protein in S.mutans (gi|9622923|),(gi|322120|) and (gi|153676|). Residues 1-325 are 82% similar to the enzyme from S.pneumoniae(gi|15903116|) and are 78% similar to enzyme from Lactococcus lactis (gi|125924|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1928 (1e-148).","

InterPro
IPR002915
Family

Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase
PF01791	$\"[21-283]T$	DeoC

InterPro
IPR005927
Family

Tagatose 1,6-diphosphate aldolase, Gram positive
TIGR01232	$\"[2-325]T$	lacD

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[4-324]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51569	$\"[6-322]T$	SSF51569

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-286 are 80% similar to a (ALDOLASE LYASE D-TAGATOSE-16-BISPHOSPHATE) protein domain (PD401329) which is seen in LACD_LACLA.Residues 288-325 are 97% similar to a (ALDOLASE LYASE D-TAGATOSE-16-BISPHOSPHATE) protein domain (PD024298) which is seen in LACD_STRMU.Residues 11-285 are identical to a (ALDOLASE TAGATOSE-BISPHOSPHATE LYASE) protein domain (PD017729) which is seen in LACD_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:27:04 2002","Tue Mar 12 13:23:25 2002","Thu Oct 17 16:27:04 2002","Tue Mar 12 13:23:25 2002","","Tue Mar 12 13:23:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1358 is paralogously related (blast p-value < 1e-3) to SMu0104, a predicted tagatose 1,6-aldolase.","Tue Mar 12 13:25:12 2002","","No significant hits to the NCBI PDB database.","SMU.1493c","","Residues 6 to 325 (E-value = 4.5e-236) place SMu1358 in the LacD family which is described as Tagatose 1,6-diphosphate aldolase, (LacD) (PF04274)","Tue Mar 12 13:23:25 2002","","","Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164","de Vos,W.M., Boerrigter,I., van Rooyen,R.J., Reiche,B. andHengstenberg,W.Characterization of the lactose-specific enzymes of thephosphotransferase system in Lactococcus lactisJ. Biol. Chem. 265 (36), 22554-22560 (1990)PubMed: 2125052van Rooijen,R.J., van Schalkwijk,S. and de Vos,W.M.Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactisJ. Biol. Chem. 266 (11), 7176-7181 (1991)PubMed: 1901863","Tue Mar 12 13:23:25 2002","Tue Mar 12 13:23:25 2002","1","","","SMU.1493c","" "SMu1359","1419623","1418691","933","ATGATGCTAACAGTTACGATGAATCCTTCCATTGATATTGCTTACCAGCTGGATGACTTAAAGGTTGATACTGTCAATCGTGTCATTGAAACGCATAAAACACCCGGAGGAAAAGGATTGAATGTGACACGTGTTCTGTCTCAGTTAGGAGACGATGTCCTTGCTAGCGGCCTTCTTGGTGGGAAACTTGGTGAATTTTTAGAAGCGGAACTTGATAAGTCTGCCATAAAGCATTCTTTTTATAAGATTTCTGCAGAGACAAGAAATTGTATTGCTATTTTACATGGTGGCTATCAAACAGAAATATTAGAACAAGGACCTTATGTTTCCGCTAAAGAATCTAAAGGGTTTCTTGAATTTTTTGAAAAATTACTTCCAAAATTAGAAGTTGTCGCAATTTCAGGAAGTCTTCCAAAAGGGGTTCCTGTAGACTATTATTCTCAAATGATTGCGATTTGCAAGCAACATCAGGTTCCTATTGTTTTGGATTGTTCAGGTCAGGCTTTGTTGGAAGTGTTAAACGGTGCAGCTAAACCAACTGTCATCAAGCCCAATACAGAAGAATTATCTCAAATTATGGAACGGGAGATTACAAATGATGTTGCTGTTTTAAAGCATGCTTTGGCTAGCCCTATCTTTTCAGGAATTGATTGGATTATTGTCTCACTTGGTTCTCAAGGTGCTTTTGCCAAGCATGGTCAAACATTTTATAAGGTCACTATTCCTAAAATAGCAGTCGTTAATCCAGTTGGTTCAGGGGATTCAACGGTAGCTGGAATTACATCGGCTCTTGCTGCAGGAGCAAGTGATGAGAAATTGCTCAAAAAAGCGAATACACTTGGTATGCTCAATGCTCAGGAAAAATTAACTGGACACGTTAACTTAGAAAATTATGATAATTTATACCAACAAATTGAGGTAGCGGAGGTTTAA","5.50","-6.44","33350","MMLTVTMNPSIDIAYQLDDLKVDTVNRVIETHKTPGGKGLNVTRVLSQLGDDVLASGLLGGKLGEFLEAELDKSAIKHSFYKISAETRNCIAILHGGYQTEILEQGPYVSAKESKGFLEFFEKLLPKLEVVAISGSLPKGVPVDYYSQMIAICKQHQVPIVLDCSGQALLEVLNGAAKPTVIKPNTEELSQIMEREITNDVAVLKHALASPIFSGIDWIIVSLGSQGAFAKHGQTFYKVTIPKIAVVNPVGSGDSTVAGITSALAAGASDEKLLKKANTLGMLNAQEKLTGHVNLENYDNLYQQIEVAEV","1418706","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1354 (lacX);SMu1355 (lacG); SMu1356 (lacE); SMu1357 (lacF);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA);SMu1362 (lacR) and SMu1451 (lacE). ","tagatose-6-phosphate kinase","Cytoplasm","This sequence corresponds to the previously published gi|153675, gi|125923, and gi|322119 in GenBank. It is similar to other predicted tagatose-6-phosphate kinases in gapped BLAST, e.g. residues 1-310 are 58% similar to gi|15903117 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1929 (8e-94).","

InterPro
IPR002139
Family

Ribokinase
PR00990	$\"[31-50]T$ $\"[219-230]T$	RIBOKINASE

InterPro
IPR002173
Family

Carbohydrate kinase, PfkB
PS00583	$\"[36-60]T$	PFKB_KINASES_1
PS00584	$\"[248-261]T$	PFKB_KINASES_2

InterPro
IPR005926
Family

Tagatose-6-phosphate kinase
TIGR01231	$\"[1-310]T$	lacC

InterPro
IPR011611
Domain

PfkB
PF00294	$\"[5-297]T$	PfkB

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.20	$\"[3-286]T$	G3DSA:3.40.1190.20
PTHR10584	$\"[5-299]T$	PTHR10584
PTHR10584:SF37	$\"[5-299]T$	PTHR10584:SF37
SSF53613	$\"[1-310]T$	SSF53613

InterPro
IPR003500
Family

Ribose/galactose isomerase
PIRSF005384	$\"[1-149]T$	RpiB_LacA_B
PF02502	$\"[2-142]T$	LacAB_rpiB
TIGR00689	$\"[3-147]T$	rpiB_lacA_lacB

InterPro
IPR004784
Family

Galactose-6-phosphate isomerase LacB subunit
TIGR01119	$\"[1-171]T$	lacB

noIPR
unintegrated

unintegrated
G3DSA:3.40.1400.10	$\"[1-158]T$	G3DSA:3.40.1400.10
SSF89623	$\"[1-155]T$	SSF89623

","BeTs to 9 clades of COG0698COG name: Ribose 5-phosphate isomerase RpiBFunctional Class: GThe phylogenetic pattern of COG0698 is -----qvcebr-ujgp----xNumber of proteins in this genome belonging to this COG is 3","***** IPB003500 (Ribose/Galactose Isomerase) with a combined E-value of 2.6e-45. IPB003500A 1-31 IPB003500B 57-98","Residues 143-171 are identical to a (ISOMERASE SUBUNIT METABOLISM LACTOSE) protein domain (PD020209) which is seen in LACB_STRMU.Residues 55-142 are 79% similar to a (ISOMERASE COMPLETE PROTEOME RIBOSE) protein domain (PD004509) which is seen in LACB_LACLA.Residues 61-107 are 48% similar to a (ISOMERASE PROTEOME COMPLETE) protein domain (PD223670) which is seen in Q9PRD9_UREPA.Residues 1-128 are 31% similar to a (ISOMERASE SUBUNIT METABOLISM LACTOSE) protein domain (PD020210) which is seen in LACA_LACLA.Residues 2-52 are 96% similar to a (ISOMERASE PROTEOME COMPLETE METABOLISM) protein domain (PD010571) which is seen in LACB_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 18:26:32 2002","Tue Mar 12 13:38:59 2002","Sun Oct 27 18:26:20 2002","Tue Mar 12 13:35:56 2002","Tue Mar 12 13:35:56 2002","Tue Mar 12 13:35:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1360 is paralogously related (blast p-value < 1e-3) to SMu1361, a predicted galactoside O-acetyltransferase.","Tue Mar 12 13:40:13 2002","","No significant hits to the NCBI PDB database.","SMU.1495c","","Residues 61 to 142 (E-value = 6.1e-48) place SMu1360 in the LacAB_rpiB family which is described as Ribose/Galactose Isomerase (PF02502)","Tue Mar 12 13:35:56 2002","","","Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164","Rosey,E.L., Oskouian,B. and Stewart,G.C.Lactose metabolism by Staphylococcus aureus: characterization oflacABCD, the structural genes of the tagatose 6-phosphate pathwayJ. Bacteriol. 173 (19), 5992-5998 (1991)PubMed: 1655695van Rooijen,R.J., van Schalkwijk,S. and de Vos,W.M.Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactisJ. Biol. Chem. 266 (11), 7176-7181 (1991)PubMed: 1901863","Tue Mar 12 13:38:59 2002","Tue Mar 12 13:38:59 2002","1","","","SMU.1495c","" "SMu1361","1420611","1420183","429","ATGGCAATTATTATTGGTTCAGATGCAGCTGGTAAAAGACTTAAAGATGTTATTAAAACATTTTTAAAAGATAACAATCATGAAGTTTTAGATGTTACTGAAAGGAAAGATTTGGATTTTGTAGATTCAACTTTAGCAGTTGTACATGAGGTACAAAAAAATGATAAAAATTTGGGAATTGCAATTGATGCCTATGGTGCGGGCAGCTTTATGGTAGCTACTAAAGTCAAAGGTATGATTGCAGCAGAAGTGTCTGATGAACGTTCAGCTTATATGACACGCGGCCATAATAATGCGCGTATCATTACTCTTGGTGCTGAAATTGTTGGAGATGAACTGGCCAAAAATATTGTTAAGGACTTTGTAGAGGCTAAATATGACGGCGGCCGTCATCAGATCCGTGTAGATATGCTAAATAAAATGTGCTAA","6.50","-1.09","15592","MAIIIGSDAAGKRLKDVIKTFLKDNNHEVLDVTERKDLDFVDSTLAVVHEVQKNDKNLGIAIDAYGAGSFMVATKVKGMIAAEVSDERSAYMTRGHNNARIITLGAEIVGDELAKNIVKDFVEAKYDGGRHQIRVDMLNKMC","1420198","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1354 (lacX); SMu1355 (lacG); SMu1356 (lacE);SMu1358 (lacD);SMu1360 (lacB); SMu1362 (lacR) and SMu1451 (lacE). ","galactose-6-phosphate isomerase","Cytoplasm","This sequence corresponds to the previously published gi|125909|,gi|322117| and gi|153673| in GenBank. It is similar to other predicted galactose-6-phosphate isomerase LacA in gapped BLAST, e.g. residues 1-142 are 76% similar to gi|15925185| from S.aureus. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1931 (7e-49).","

InterPro
IPR003500
Family

Ribose/galactose isomerase
PIRSF005384	$\"[1-142]T$	RpiB_LacA_B
PF02502	$\"[2-139]T$	LacAB_rpiB
TIGR00689	$\"[3-141]T$	rpiB_lacA_lacB

InterPro
IPR004783
Family

Galactose-6-phosphate isomerase LacA subunit
TIGR01118	$\"[1-141]T$	lacA

noIPR
unintegrated

unintegrated
G3DSA:3.40.1400.10	$\"[1-141]T$	G3DSA:3.40.1400.10
SSF89623	$\"[1-141]T$	SSF89623

","BeTs to 8 clades of COG0698COG name: Ribose 5-phosphate isomerase RpiBFunctional Class: GThe phylogenetic pattern of COG0698 is -----qvcebr-ujgp----xNumber of proteins in this genome belonging to this COG is 3","***** IPB003500 (Ribose/Galactose Isomerase) with a combined E-value of 1.3e-39. IPB003500A 1-31 IPB003500B 55-96","Residues 59-138 are 41% similar to a (ISOMERASE COMPLETE PROTEOME RIBOSE) protein domain (PD004509) which is seen in RPIB_ECOLI.Residues 1-142 are identical to a (ISOMERASE SUBUNIT METABOLISM LACTOSE) protein domain (PD020210) which is seen in LACA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:25:10 2002","Tue Mar 12 13:43:55 2002","Thu Oct 17 16:25:10 2002","Tue Mar 12 13:42:58 2002","Tue Mar 12 13:42:58 2002","Tue Mar 12 13:42:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1361 is paralogously related (blast p-value < 1e-3) to SMu1360, a predicted galactose-6-phosphate isomerase.","Tue Mar 12 13:46:52 2002","","No significant hits to the NCBI PDB database.","SMU.1496c","","Residues 59 to 139 (E-value = 3.1e-44) place SMu1361 in the LacAB_rpiB family which is described as Ribose/Galactose Isomerase (PF02502)","Tue Mar 12 13:42:58 2002","","","Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164","Oskouian,B. and Stewart,G.C.Repression and catabolite repression of the lactose operon ofStaphylococcus aureusJ. Bacteriol. 172 (7), 3804-3812 (1990)PubMed: 2163387","Tue Mar 12 13:45:55 2002","Tue Mar 12 13:45:55 2002","1","","","SMU.1496c","" "SMu1362","1421673","1420918","756","ATGAGGAAGGAAGAACGATTAGAAGAAATCACAAAACTCATTAATAAGCGAGGAACCATTCGGGTTACTGAAGTTGTGGAACGATTAAAGGTATCAGACATGACTGTCCGTCGCGATTTAACTGAATTGGAAGGCTTGGGAGTATTAACACGTATTCACGGTGGGGCTAGAAGCAATAATATTTTTCAATATAAAGAAATGTCCCATGAAGAAAAGCATTCTCGACAAATAGAAGAAAAGCACTATATTGCACAAAAGGCTGCCGAGTTAGTAGAAGAAGGAGATACGATCTTTTTAGGACCGGGAACAACTGTAGAACTGCTGGCTGAAGAGATTAATAAGACAACTTTGCAAGTCATCACCAATTGTCTTCCTGTTTTTCAGATCTTATCGCAAAAGCAATCAGAGACGTTTAGAGTCCATTTATTGGGCGGCGAAATGAGAAGTATCACTCAGTCTTTTATTGGAGAAATAACAAATATCGTTTTAGAAAAAATGCATTTTTCTAAAATGTTTTTCAGCGGCAATGGTGTCAAAGGAAATGAAGTGATGACATCAAGTTTCCAAGAAGCTTATACTCAGAAGATGGCTTTAGGAAGGGCAATTGAAAAATATTTGCTGATTGACTCTTCAAAGATTGGAAAAGAAGATTTTACGTCATTTTATCAGCTGTCACAATTGACAGCTCTGATTACAGATTGTCAAGATGACGATAAGCTTCAAAAACTGAGCAAATATACTGAGATTATTAACTAA","6.30","-2.63","28690","MRKEERLEEITKLINKRGTIRVTEVVERLKVSDMTVRRDLTELEGLGVLTRIHGGARSNNIFQYKEMSHEEKHSRQIEEKHYIAQKAAELVEEGDTIFLGPGTTVELLAEEINKTTLQVITNCLPVFQILSQKQSETFRVHLLGGEMRSITQSFIGEITNIVLEKMHFSKMFFSGNGVKGNEVMTSSFQEAYTQKMALGRAIEKYLLIDSSKIGKEDFTSFYQLSQLTALITDCQDDDKLQKLSKYTEIIN","1420933","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1354 (lacX); SMu1355 (lacG); SMu1356 (lacE);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA) and SMu1451 (lacE). ","lactose phosphotransferase system repressor","Cytoplasm","This sequence corresponds to the previously published gi|125938|,gi|322121|,gi|153674| and gi|153672| in GenBank. It is similar to other predicted lactose phosphotransferase system repressor in gapped BLAST, e.g. residues 1-251 are 64% similar to gi|15925186| from S.aureus. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1936 (1e-53).","

InterPro
IPR001034
Domain

Bacterial regulatory protein, DeoR N-terminal
PR00037	$\"[24-38]T$ $\"[38-56]T$	HTHLACR
PF08220	$\"[6-62]T$	HTH_DeoR
SM00420	$\"[6-58]T$	HTH_DEOR
PS00894	$\"[6-40]T$	HTH_DEOR_1
PS51000	$\"[3-58]T$	HTH_DEOR_2

InterPro
IPR014036
Domain

Bacterial regulatory protein, DeoR
PF00455	$\"[77-233]T$	DeoR

noIPR
unintegrated

unintegrated
SSF100950	$\"[74-237]T$	SSF100950
SSF46785	$\"[2-81]T$	SSF46785

","BeTs to 3 clades of COG1349COG name: Transcriptional regulators of sugar metabolismFunctional Class: K,GThe phylogenetic pattern of COG1349 is ------v-EB-H---------Number of proteins in this genome belonging to this COG is 4","***** IPB001034 (Bacterial regulatory protein, DeoR family) with a combined E-value of 7.1e-45. IPB001034A 20-55 IPB001034B 80-104 IPB001034C 120-130 IPB001034D 144-156 IPB001034E 205-215","Residues 142-243 are 99% similar to a (DNA-BINDING REGULATION TRANSCRIPTION TRANSCRIPTIONAL) protein domain (PD002430) which is seen in LACR_STRMU.Residues 1-96 are 98% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD002333) which is seen in LACR_STRMU.Residues 97-141 are identical to a (REPRESSOR LACTOSE PHOSPHOTRANSFERASE) protein domain (PD031013) which is seen in LACR_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:24:45 2002","Tue Mar 12 13:53:31 2002","Thu Oct 17 16:24:45 2002","Tue Mar 12 13:49:18 2002","Tue Mar 12 13:49:18 2002","Tue Mar 12 13:49:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1362 is paralogously related (blast p-value < 1e-3) to SMu0793, SMu0460, and SMu0445 all predicted lactose repressors.","Tue Mar 12 13:56:59 2002","","No significant hits to the NCBI PDB database.","SMU.1498c","","Residues 6 to 233 (E-value = 8.3e-124) place SMu1362 in the DeoR family which is described as Bacterial regulatory proteins, deoR family (PF00455)","Tue Mar 12 13:49:18 2002","","","Rosey,E.L. and Stewart,G.C.Nucleotide and deduced amino acid sequences of the lacR, lacABCD,and lacFE genes encoding the repressor, tagatose 6-phosphate genecluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutansJ. Bacteriol. 174 (19), 6159-6170 (1992)PubMed: 1400164","Oskouian,B. and Stewart,G.C.Repression and catabolite repression of the lactose operon ofStaphylococcus aureusJ. Bacteriol. 172 (7), 3804-3812 (1990)PubMed: 2163387","Tue Mar 12 13:53:31 2002","Tue Mar 12 13:53:31 2002","1","","","SMU.1498c","" "SMu1363","1425536","1421898","3639","ATGACCTTTAAACCATTTTTAACAGATCAAGAAATAGCTTCCTTACAAATTCAAGAAGCTCAGTCTGATAAGAAACAAAAACGAACGCCTGAGCAAATTGAGGCTATTTACACTTCAGGAACCAATATTTTGGTTTCTGCCTCTGCTGGTTCAGGAAAAACCTTTGTGATGATTGAGCGGATTATGGATAAAATTCTGCGTGGTGTAACGATTGATCAGCTTTTTATTTCCACCTTTACCGTTAAGGCTGCTGGTGAGCTTAAGGAGCGTTTAGAAAAGAAAATCACCGAGCAATTGCGTTTGACAAATGACACTGCCCTCAAACAATTTCTCAGCGAACAACTCTTGGGATTGCAGACTGCGGATATTGGAACCATGGATGCCTTTACCCAAAAATTAGTGACACAGTACGGCTATACCTTGGGAATTTCACCGAATTTTCGAATTTTACAAGATAAAAGCGAGCAGGATCTTCTTAAAAATGATGTCTTTGACGACCTTTTTACTGATTACAGAACTGGCGATCAAGCAGAGCTTTTCACTAAGCTTGTTAGGAATTTTGCTGGAAATCGAAAAGATTCGAGCAATTTTAGACAAATCATTTACAAAATTTATGATTTCAGTCAGGCAACCGATAATCCCCAAAGATGGCTTTTGGAGAATTTCTTAAAGGGAGCCAATACCTATAAGGATTTTTCAGCTATTCCTGAACAAGAAGTGAAAGACTTTTTGAATACTTTGCAGGAAACTGCTCTCGCTCTTCGTGATGTGACGGATTTAGAAGATTACAAGCAAGTAACGGCTAAAGGAACTCCAACAGCAGCTTATCAAAGGCACCTTAAAATGATTGAGCAGCTGCAGGATTGGGTCTTGCATTTTGACAGTCTATATGGGCGAGATGGTCTGGGGAAATTAGCAAATGACATTGCAACACTCATTCCATCTGGTAACGATGTGACAGTAGCAGGAGTTAAATATCCTGTCTTTCGCAGTTTGCACAGTCGCTTAAGAGGACTAAAACACTTGGAAACAATTTTCAAGTATCAGGATCAAAGTCTGCCTTTGTTGCAAGTACTGCAATCTTTTACACTTGATTTTTCAAAACAATACCTGCAAGCAAAGATGCAGGAAAATGCCTTTGAGTTTTCAGACATTGCACATTTTGCTATCCAGATTTTAGAAGAAAATGATGCTATTCGTCAGCTTTATATAGATAAGTATCACGAAGTCATGGTAGATGAATATCAGGATAATAATCACACCCAAGAGCGCATGTTGGAACTTTTATCTAATGGGCGCAATCGCTTCATGGTAGGAGATATTAAGCAATCTATCTATCGGTTTCGTCAGGCAGATCCACAGATTTTTAATCAAAAATTTAAGGATTTTCAAGAACATCCAGAGCATGGAAAACTCATTCTCTTAAAAGAGAACTTTCGGAGTCAGTCAGAAGTCTTAGATGCTACCAATAGTGTTTTTACGCATCTTATGGATGAAGCGGTTGGAGAAATTCTCTACGATGATACCCATCAGCTTGTGGCTGGCAGTTCAGCTCAGAAAATTCCTTATCCGCAAAATGAAACACAAGTCCTCATCTATGATACAAAGGATCAGCAAAATCAAGATCTTGCTGTAGAAGATGATAGTAATCAAATCAGTCTAGGTGAGGTCAAATTGGTTGCTAAGGAGATTATTCGCCTTCATAATGAAGAAAAGGTTCAGTTTGAAGATATTACCTTGCTTGTCTCATCGCGGACACGCAATGATGGTATCTTGCAAACATTTGATGATTATGGCATTCCTTTGGTGACTGATGGTGGTGAACAAAATTATCTGAAATCAGTGGAAGTTATGGTCATGTTGGATACTCTGCGTTCTATTGATAATCCTCTCAATGATTATGCTCTAGTAGCTCTTTTGCGTTCACCTATGTTTGCTTTTGATGAGGATGACTTGGCTCGTCTAGCTCTGCAAAATCTACCAGATCAACACAAACAAAATCTTTATGAAAAGATGGAGAATGCCAGAAATGGCCAAGGCCAGCAAGTTCAGTTGATCACAGAAGCATTGTCTGCCAAATTGGATGCTTTCTTTGAAACTTTCCTCAGTTGGCGTGAGTTTAGTCTCTTAAATTCGCTCTATGATTTGATTTGGAAAATTTATAATGATAAATTTTACTATGATTATGTGGGAAGTTTACCAAAATCTGAACAGCGCCAAGCCAATCTTTATGCTCTAGCCCTGCGTGCCGATAACTTTGAGAAAACAGGTTTTAAGGGGTTGTCGCGCTTCATTCGCATGATTGACAAAATTCTAGAAAATCAAAATGACTTGGCTGATGTTGAAGTCGCTTTACCTAAAAATGCAGTGACGCTGATGACGATTCATAAGAGTAAGGGATTGGAATTTAAATATGTCTTTATTCTTAATATTGATAAAAAATTTAGCATTCAAGATATGACATCACCCTTAATTTTATCGCGGCAAAACGGTGTTGGTATCAAGTATATTGCTGATATGAAAGAAGAACTAGAGGAAAAATTATTGCCGACAGTTAAAGTCAGCATGGATACTCTTCCTTATCAACTGAATAAGCGTGAGCTTCGCCTGGCAACCCTATCTGAACAAATGCGATTGCTTTATGTTGCCATGACACGATCTGAAAAGAAACTTTACTTGGTCGGAAAAGGCAGTCAGGAAAAATTAGGGGATCAGTATGATGGCAAATCAGAAAACAATCATTTGCCAGTAGCTGATCGTGAACACTATTTGACTTTTCAGGATTGGCTTTTGGCGATTGAAGCTGCTTATGCTGCCGATGAACTTCATTTTAAAACAAGTTTTATAACGGATGAAGACTTAACAGAAGATAAAATGGGAAGTTTAGAAGCAGAGCAGGCTTATGATGCGGATAATCTTAAGGATAATCGGCAATCAGATGATATTACGCGTGCTTTAGATATGTTAGAAGCAGTTGAAAAATTAAATCAGCACTATAAGGCTGCTATCCATTTACCAACTGTTCGTACGCCAAGTCAGATCAAAAAATTTTATGAGCCTGTTATGGAAACAGAAGGTGTAGAGGTGATGCAAACTTCCTATCAGACTAAACCAAAGTTTGAGCTGCCTCAATTTTCAAAAAAGGCGAAACAAGATCCAACAGCTCTTGGTTCAAGTGTTCATGAACTTATGCAGCGGCTTCATTTGAGTGAACAGGTTAGTCTTGAAGATATTTTAACTGCTCTGGCAGAACTATCTGTAGAAGAAAATGTTAAAAAAGCTATTCAGGTTGATAAGATTTTGCATTTCTTCCAGACCAGCCAACTGGGGAAACTCATTCAAGCAAATGCTGACAAGGTCTATCGTGAAGCACCCTTTGCTATGCTGCAAGCGGATCCTGCAAGCGGAGAAGACTATGTCGTGCGGGGGATTATTGACGGTTACATTCTTTTTGATAATCGGATTGTCCTCTTTGATTATAAAACAGATAAATTCACTAATAGTCAAGCTATTAAAGAGCGTTACCGAGGTCAGATGACACTTTATGCTCAAGCTTTGAGCCAATCCTATAATATCCAACAAGTAGACAGTTATTTAATTCTATTAGGCGGTGAAAAATTAGAAGTTGTGGAAATTTAA","4.90","-39.53","139293","MTFKPFLTDQEIASLQIQEAQSDKKQKRTPEQIEAIYTSGTNILVSASAGSGKTFVMIERIMDKILRGVTIDQLFISTFTVKAAGELKERLEKKITEQLRLTNDTALKQFLSEQLLGLQTADIGTMDAFTQKLVTQYGYTLGISPNFRILQDKSEQDLLKNDVFDDLFTDYRTGDQAELFTKLVRNFAGNRKDSSNFRQIIYKIYDFSQATDNPQRWLLENFLKGANTYKDFSAIPEQEVKDFLNTLQETALALRDVTDLEDYKQVTAKGTPTAAYQRHLKMIEQLQDWVLHFDSLYGRDGLGKLANDIATLIPSGNDVTVAGVKYPVFRSLHSRLRGLKHLETIFKYQDQSLPLLQVLQSFTLDFSKQYLQAKMQENAFEFSDIAHFAIQILEENDAIRQLYIDKYHEVMVDEYQDNNHTQERMLELLSNGRNRFMVGDIKQSIYRFRQADPQIFNQKFKDFQEHPEHGKLILLKENFRSQSEVLDATNSVFTHLMDEAVGEILYDDTHQLVAGSSAQKIPYPQNETQVLIYDTKDQQNQDLAVEDDSNQISLGEVKLVAKEIIRLHNEEKVQFEDITLLVSSRTRNDGILQTFDDYGIPLVTDGGEQNYLKSVEVMVMLDTLRSIDNPLNDYALVALLRSPMFAFDEDDLARLALQNLPDQHKQNLYEKMENARNGQGQQVQLITEALSAKLDAFFETFLSWREFSLLNSLYDLIWKIYNDKFYYDYVGSLPKSEQRQANLYALALRADNFEKTGFKGLSRFIRMIDKILENQNDLADVEVALPKNAVTLMTIHKSKGLEFKYVFILNIDKKFSIQDMTSPLILSRQNGVGIKYIADMKEELEEKLLPTVKVSMDTLPYQLNKRELRLATLSEQMRLLYVAMTRSEKKLYLVGKGSQEKLGDQYDGKSENNHLPVADREHYLTFQDWLLAIEAAYAADELHFKTSFITDEDLTEDKMGSLEAEQAYDADNLKDNRQSDDITRALDMLEAVEKLNQHYKAAIHLPTVRTPSQIKKFYEPVMETEGVEVMQTSYQTKPKFELPQFSKKAKQDPTALGSSVHELMQRLHLSEQVSLEDILTALAELSVEENVKKAIQVDKILHFFQTSQLGKLIQANADKVYREAPFAMLQADPASGEDYVVRGIIDGYILFDNRIVLFDYKTDKFTNSQAIKERYRGQMTLYAQALSQSYNIQQVDSYLILLGGEKLEVVEI","1421913","For other 'rex' genes see SMu1364 (rexB). For ATP-dependent exonuclease, subunit B see SMu1364. ","ATP-dependent exonuclease subunit A","Cytoplasm, Extracellular","This sequence corresponds to the previously published gi322122in GenBank.Residues 1132-1212 are 100% similar to orf X 5' of lacR in S.mutans (fragment).Numerous hits in gapped BLAST to ATP-dependent exonuclease, subunit A:residues 1-1212 are 60% similar to the enzyme from S.pyogenes and are 52% similar to the enzyme from S.pneumoniae (gi15901017).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0874 (0.0).","

InterPro
IPR000212
Family

UvrD/REP helicase
PTHR11070	$\"[40-96]T$ $\"[116-178]T$ $\"[329-525]T$ $\"[557-702]T$ $\"[722-824]T$ $\"[870-1212]T$	UvrD_helicase
PF00580	$\"[28-726]T$	UvrD-helicase

InterPro
IPR014016
Domain

Helicase superfamily 1, UvrD-related
PS51198	$\"[26-482]T$	UVRD_HELICASE_ATP_BIND

InterPro
IPR014017
Domain

UvrD-like DNA helicase, C terminal
PS51217	$\"[510-800]T$	UVRD_HELICASE_CTER

InterPro
IPR014152
Family

Recombination helicase AddA
TIGR02785	$\"[27-1210]T$	addA_Gpos

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[25-469]T$ $\"[476-905]T$	G3DSA:3.40.50.300
SSF52540	$\"[17-898]T$	SSF52540

","BeTs to 3 clades of COG1074COG name: ATP-dependent exoDNAse (exonuclease V), beta subunit, - helicase and exonuclease domainsFunctional Class: LThe phylogenetic pattern of COG1074 is --------ebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000212 (UvrD/REP helicase) with a combined E-value of 4.5e-49. IPB000212A 47-57 IPB000212B 74-91 IPB000212C 412-423 IPB000212D 438-451 IPB000212E 475-493 IPB000212F 790-808 IPB000212G 875-887","Residues 27-95 are 68% similar to a (HELICASE DNA PROTEOME COMPLETE ATP-BINDING DNA-BINDING) protein domain (PD000627) which is seen in Q9CJI9_LACLA.Residues 690-779 are 47% similar to a (EXONUCLEASE ATP-BINDING SUBUNIT) protein domain (PD414281) which is seen in O54378_BBBBB.Residues 368-492 are 63% similar to a (HELICASE DNA PROTEOME COMPLETE ATP-DEPENDENT ATP-BINDING) protein domain (PD001658) which is seen in Q9CJI9_LACLA.Residues 111-366 are 31% similar to a (EXONUCLEASE SUBUNIT ATP-DEPENDENT) protein domain (PD354953) which is seen in Q9CJI9_LACLA.Residues 525-653 are 29% similar to a (NUCLEASE SUBUNIT ATP-DEPENDENT) protein domain (PD040033) which is seen in ADDA_BACSU.Residues 89-195 are 32% similar to a (A PROTEOME SUBUNIT COMPLETE) protein domain (PD318203) which is seen in Q9K8M6_BACHD.Residues 355-456 are 33% similar to a (HELICASE COMPLETE PROTEOME DNA) protein domain (PD126505) which is seen in O83868_TREPA.Residues 577-773 are 46% similar to a (EXONUCLEASE PROTEOME SUBUNIT COMPLETE) protein domain (PD407802) which is seen in Q9CJI9_LACLA.Residues 814-1211 are 39% similar to a (EXONUCLEASE SUBUNIT ATP-DEPENDENT) protein domain (PD042577) which is seen in Q9CJI9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 16:56:46 2006","Thu May 2 11:42:05 2002","Tue Aug 1 16:56:46 2006","Tue Mar 12 14:00:54 2002","Tue Mar 12 14:00:54 2002","Tue Mar 12 14:00:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1363 is paralogously related (blast p-value < 1e-3) to SMu1075, a predicted ATP-dependent DNA helicase .","Tue Mar 12 14:12:43 2002","Tue Aug 1 16:56:46 2006","pdb3PJRA Chain A, Helicase Substrate Complex >gi2781090pdb... 114 6e-026pdb1UAAB Chain B, Structure Of The Rep Helicase-Single Strand... 98 8e-021pdb2PJRA Chain A, Helicase Product Complex >gi9257173pdb2P... 89 4e-018","SMU.1499c","","Residues 28 to 726 (E-value = 8.2e-74) place SMu1363 in the UvrD-helicase family which is described as UvrD/REP helicase (PF00580)","Tue Mar 12 14:00:54 2002","","","","","Thu Oct 24 12:13:17 2002","","1","","","SMU.1499c","100" "SMu1364","1428768","1425526","3243","ATGAAACTACTTTACACCGACATTCAATACAATATGATAGATATTTTAGCTGGGGAAGCGCAGTTGGCTGCTAAGGCTGGCAAGCGAGTCTTTTATATTGCTCCCAACTCCTTGTCTTTTGAGAAGGAGCGAGCTGTTTTGGAGACCCTGCCTGAGCGGGCTTCCTTTGCTATTACCATTACGCGTTTTGAGCAAATGGCACGTTATTTTGTTTTAAATGATATTCATCAGGGCGAAACCATTGATGATAATGGACTTGTTATGGTTTTTTATCGTGTTTTATCCAGTTTTTCAGACCAAGATTTGCGAGTTTTTGGGCGTCTTAAGCAAGATGCTCATTTTATCAATCAATTGGTGGATTTGTATAAGGAACTCAAGGCTTCTAATCTGACTGTCTTAGAATTAAATCAGCTAAATTCGGCTGAAAAGCAGGAAGATTTGATTAAGATTTTTACAGAGGTTGAAACCATTTTAAGTGCTGGCCATTTTGATAATCAAAGCAAGATTGCCTTCTTTGCACAACAGATCAAATTCGGTCATTTAGATACGGCTTTGCAGGATTTGACAATTGTTATTGATGGTTTCACACGTTTTTCTGCTGAAGAAGAAAATCTGATAGGACTGTTACATGAAAAAGGTGTTGACATTATCATTGGGACTTATATTAGTCAAAAAGCTTATCGTTCAACTTTTTCGAATGGGAATGTCTATCAGGCTAGTCTTGATTTCATTCGTGGTTTGGCTGGTAAATTTCAAACCAAACCAGAATATGTGGTATCAAAGCAAGAAGCTTTGCCTGCCTTTACCAAACTTTCTCAGCTATTTGAAAGTTGTCATGATTTTTCGGACAGTCAGCTGGTCTTGACAGATAAGGACAAGGAACATGTAACTATCTGGGATGTCATTAATCAAAAAGAAGAAGTGGAACATGTTGCTAAGAGCATTCGCCGGAAACTCTATGAAGGTCATCGTTACAAGGATATTTTGGTCCTTCTTGGGGATGCGGATGCCTATAAACTGCAGATTGGCAAGATTTTTGATAAGTATGAAATTCCCTATTATTTTGGCAAAGCGGAGTCCATGAGTTCGCACCCGCTGGTTCATTTTGTGGATTCTTTGGAGCGGGTTAAACGTTATAATTTTCGTGCTGAGGATGTCATGAATCTGCTCAAATCAGGCCTATATGGCAAAATCAGGCAAAATCAGTTAGATAAATTGGAGCAGTATGTCATTTATGCTGATATTAAAGGAAAAACAAAGTTTTTTAAGGACTTTACGCTAGATAATCATGGGCAATTTGATCTAAAAGCCTTAAATAAACTGCGGGCAGAAGTCATGTCACCTTTACAAGAGCTGATTAAAATACAGGCCCAAAAGGGAGACAGTATCCTGCAAAAATTGACCAACTTTTTAGAAGCCATTTCTTTAACGAATAATTTTTCAAAATTAATCCAAGGTGTCAGTGACACTGAGCAGGAAAAGAACGAGCAAGTTTGGAAAACTTTTACGGTTATTTTAGAGCAATTTCATACGATTTTTGGACAAGAAAAAATGAAGTTGGCTGATTTTCTGGCACTCTTACGCAGCGGCATGCTGGCGGCTGATTATCGGACGGTTCCTGCCAGTGTTGATGTTGTGACAGTTAAGTCTTATGATTTGGTGGAGCCCCATAGCAATAAATTTGTTTTTGCTCTGGGAATGACCCAGTCTCATTTTCCTAAAATTGTCCAAAATAAGAGTCTTATTTCGGATGAAGAACGTGCAAAAATCAATGAAGCAACTCCTGACAATCGTCGTTTTGATATTGTCACTAAGGAAAATCTCAAGAAAAATCATTTCACCGCCCTGTCACTCTTCAATGCGGCCACTCAGGAATTGGTCTTAACCTTGCCGCAGATTTTAAACGAGGCAGAGGACAACACCTCCTCCTATTTGCTTGAATTGCAAGATATGGGTGTGCCAGTTGTCGAAAAGGGGGGCAATCGTTTAGCTGCGGATCCAGAAGATATTGGCAATTACAAGGCGCTTTTGTCGCGTGTGATTGAGCTTAACCGCTCTGCTATTGACCAAGAATTATCTAAAGAAGAGCAGACCTTTTGGTCAGTTGCTGTTCGCTATTTACGCCAAAAATTGGCAAAAGAAGGACTTACGATTCCTGAAGTGAACGATAAGATGCAGACCAAGCAGGTCGCTGCAGAGGTTATGGCAGCACGTTTTCCAATAGATCAACCTTTAAATCTATCATCGTCTGCCCTGACAACTTTTTACAATAACCAGTATCTCTATTTCCTTCAATATATCCTTGGTTTGCAAGAGCTTGAAACGATTCATCCTGATGCTAGAAATCATGGGACTTATTTGCACCGCGTGTTTGAATTGGTTATGCAAGATCAATCTACTGATGATTTTGACAGTAAATTAAATCGTGCCATTGATATAACCAACCATGAGGATAGCTTTCACTTGGTTTATAATGAAGATGAGGAAAGTCGCTATGCTTTGGGTATTTTAGAAGATATTGCTCGTAGTACAGCTACCGTTTTAAAAGGGGATAATCCTGTTCAGGCAGAAAGTGAAGAAGAAGCCTTTGAGTTAATGCTGGATCAGGCTGTTAAAATCAGAGGGGTTATTGATCGCATTGATCGCTTGTCAGATGGCAGTTTAGGAATTGTTGATTATAAATCAAGTAAAAATACCTTTGATCTGCAAAAATTTTACAATGGACTCAGTCCGCAGTTAGTGACTTATATAGAAGCTCTTCGGTCTTGTAAAAATTTGAATGATACAGATAAGATTTTTGGAGCCATGTATCTTCATATGCAGGAACCTAAAACTGATTTAGCCAATATGAAATCCATCGAAAAAATTCCGGAAACGGTTCATAAGAATTTAAGTTATAAGGGACTCTTTTTAGAAGATGAAAAAGCACATTTGGCTAATGGGAAATACCATTTGCATGATGCTGTCTATAGTCAAAAAGAAGTTGATTTGCTGCTTGATTATAATAAAAGACTCTATCGCAGTGCCGCAAAGCAAATCAGAAAAGGAAACTTTCTCATTAACCCCTACAGTCAGGATGGCAAATCTGTTCAGGGAGAACAGCTGAAGGCTATTACACATTTTGAAGCAGATCGCCACATGCCTTATGCTCGTAAACTTTATCAGCTGCCACGCAAAGAAAAACGTCAGGGTTTCTTGGCGTTAATGCAGTCTAAAAAAGAGGAGGAAGGTAATGACCTTTAA","6.00","-17.21","123791","MKLLYTDIQYNMIDILAGEAQLAAKAGKRVFYIAPNSLSFEKERAVLETLPERASFAITITRFEQMARYFVLNDIHQGETIDDNGLVMVFYRVLSSFSDQDLRVFGRLKQDAHFINQLVDLYKELKASNLTVLELNQLNSAEKQEDLIKIFTEVETILSAGHFDNQSKIAFFAQQIKFGHLDTALQDLTIVIDGFTRFSAEEENLIGLLHEKGVDIIIGTYISQKAYRSTFSNGNVYQASLDFIRGLAGKFQTKPEYVVSKQEALPAFTKLSQLFESCHDFSDSQLVLTDKDKEHVTIWDVINQKEEVEHVAKSIRRKLYEGHRYKDILVLLGDADAYKLQIGKIFDKYEIPYYFGKAESMSSHPLVHFVDSLERVKRYNFRAEDVMNLLKSGLYGKIRQNQLDKLEQYVIYADIKGKTKFFKDFTLDNHGQFDLKALNKLRAEVMSPLQELIKIQAQKGDSILQKLTNFLEAISLTNNFSKLIQGVSDTEQEKNEQVWKTFTVILEQFHTIFGQEKMKLADFLALLRSGMLAADYRTVPASVDVVTVKSYDLVEPHSNKFVFALGMTQSHFPKIVQNKSLISDEERAKINEATPDNRRFDIVTKENLKKNHFTALSLFNAATQELVLTLPQILNEAEDNTSSYLLELQDMGVPVVEKGGNRLAADPEDIGNYKALLSRVIELNRSAIDQELSKEEQTFWSVAVRYLRQKLAKEGLTIPEVNDKMQTKQVAAEVMAARFPIDQPLNLSSSALTTFYNNQYLYFLQYILGLQELETIHPDARNHGTYLHRVFELVMQDQSTDDFDSKLNRAIDITNHEDSFHLVYNEDEESRYALGILEDIARSTATVLKGDNPVQAESEEEAFELMLDQAVKIRGVIDRIDRLSDGSLGIVDYKSSKNTFDLQKFYNGLSPQLVTYIEALRSCKNLNDTDKIFGAMYLHMQEPKTDLANMKSIEKIPETVHKNLSYKGLFLEDEKAHLANGKYHLHDAVYSQKEVDLLLDYNKRLYRSAAKQIRKGNFLINPYSQDGKSVQGEQLKAITHFEADRHMPYARKLYQLPRKEKRQGFLALMQSKKEEEGNDL","1425541","For other 'rex' genes see SMu1363 (rexA).For ATP-dependent exonuclease, subunit A see SMu1363.","ATP-dependent exonuclease subunit B","Cytoplasm, Extracellular","Numerous hits in gapped BLAST to ATP-dependent exonuclease, subunit B:residues 1-1072 are 53% similar to the enzyme from S.pyogenes (gi15674821) and residues 1-1077 are 50% similar to the enzyme from S.criceti (gi15128574).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0873 (0.0).","

InterPro
IPR014141
Family

ATP-dependent nuclease subunit RexB
TIGR02774	$\"[2-1069]T$	rexB_recomb

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[271-573]T$	G3DSA:3.40.50.300
SSF52540	$\"[5-592]T$	SSF52540

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-1076 are 32% similar to a (EXONUCLEASE B SUBUNIT ATP-DEPENDENT) protein domain (PD044203) which is seen in O54377_BBBBB.Residues 673-909 are 26% similar to a (PROTEOME COMPLETE CJ1482C) protein domain (PD147825) which is seen in Q9PMI0_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 12:36:27 2006","Thu May 2 11:41:33 2002","Tue Aug 1 12:34:24 2006","Tue Mar 12 14:18:26 2002","","Tue Mar 12 14:18:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1364 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 2 09:55:18 2002","","No significant hits to the NCBI PDB database.","SMU.1500c","","No significant hits to the Pfam 11.0 database","Thu May 2 11:41:33 2002","","","","El-Karoui,M., Ehrlich,D. and Gruss,A.Identification of the lactococcal exonuclease/recombinase and itsmodulation by the putative Chi sequenceProc. Natl. Acad. Sci. U.S.A. 95 (2), 626-631 (1998)PubMed: 9435243","","Tue Mar 12 14:18:26 2002","1","","","SMU.1500c","99" "SMu1365","1429885","1429640","246","ATGTTGATATTAGGTTGGGTAGCGACTTTTATGTCTATAATGATGTATGTGTCTTATATCCCTCAGATTATGAATAATTTAGCAGGAAATAAGGGGGATTTTATCCAACCGTCAGTGGCTGCACTTAACTGCACACTGTGGGTAATTTATGGTCTTTGTAAAGAAAAGCGAGACCTTCCTTTAGCTGCCGCCAATATGCCAGGCATTGTTTTTGGCTTGATTGCAGCGATTACGGCATTAGTTTAG","8.10","0.88","8776","MLILGWVATFMSIMMYVSYIPQIMNNLAGNKGDFIQPSVAALNCTLWVIYGLCKEKRDLPLAAANMPGIVFGLIAAITALV","1429655","","conserved hypothetical protein","Membrane, Cytoplasm","Only one hit in gapped BLAST to an unknown:residues 4-80 are 68% similar to gi|15672611| from Lactococcus lactis. SMu1365 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-18]?$	signal-peptide
tmhmm	$\"[5-20]?$ $\"[34-52]?$ $\"[62-80]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-80 are 68% similar to a (PROTEOME COMPLETE) protein domain (PD391884) which is seen in Q9CHT9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 22 09:17:47 2002","Tue Mar 12 14:20:37 2002","Fri Mar 22 09:17:47 2002","Tue Mar 12 14:20:37 2002","","Tue Mar 12 14:20:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1365 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 22 09:17:47 2002","","No significant hits to the NCBI PDB database.","SMU.1502c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 14:20:37 2002","24379893","","","","","","1","","","SMU.1502c","" "SMu1366","1430386","1430060","327","ATGACACATGTTGTATCTGAAATTTTTAAAGATGGCCCGGTAGACAGGTTTGGTTTACGAGGGGATCCTGTTTTTTGGAACTATTTAGAAAAGCATTTTCAAAAGGTAGCTATGCCATATTCCGAAAGAAAATTAGAAGAGGATATAAGAACGATCTATCAAGACTTAACTGGAAAAGAATTTAGAATGGGTGAGATGGCTCTTGTTAAAGACTTTATAAGTGAATCCGGCGGCATGTCATCAGGATGGCTTAGTGATGATTTTTGGCTTAAATCAGCTATACCGCTTCTGAAAAAACGATTGGCAAAATGGAATGAAACTTTATAA","6.50","-0.53","12618","MTHVVSEIFKDGPVDRFGLRGDPVFWNYLEKHFQKVAMPYSERKLEEDIRTIYQDLTGKEFRMGEMALVKDFISESGGMSSGWLSDDFWLKSAIPLLKKRLAKWNETL","1430075","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1366 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:41:54 2002","Tue Mar 12 14:21:45 2002","Tue Mar 12 14:21:45 2002","Tue Mar 12 14:21:45 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1366 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:41:54 2002","","No significant hits to the NCBI PDB database.","SMU.1504c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 14:21:45 2002","24379894","","","","","","1","","","SMU.1504c","" "SMu1367","1430869","1430750","120","ATGGCCTACAGCCTGACTTTCCAAAATCCTAATGATAATCTCACAGATGAAGAAGTTGCCAAATACATGGAAAAAATCACCAAAGCCCTAACCGAAAAAATTGGTGCAGAAGTGAGGTAA","4.60","-2.02","4445","MAYSLTFQNPNDNLTDEEVAKYMEKITKALTEKIGAEVR","1430765","This 39 residue open reading frame is a fragment of phenylalanyl-tRNA synthetase beta subunit.For other 'phe' genes see SMu0713 (pheA); SMu1788 (pheT); SMu1178 (pheA); SMu1372 (pheT) and SMu1374 (pheS).For phenylalanyl-tRNA synthetase (beta subunit) see SMu1372.For phenylalanyl-tRNA synthetase (alpha subunit) see SMu1374.For probable phenylalanyl-tRNA synthetase,beta subunit see SMu1788. ","conserved hypothetical protein (phenylalanyl-tRNA synthetase fragment)","Cytoplasm","Limited significant hits in gapped BLAST to phenylalanyl-tRNA synthetase (beta subunit): residues 1-39 are 94% similar to the enzyme from S.pyogenes (gi|15674815|) and are 76% similar to the enzyme from S.pneumoniae (gi|15902553|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0871 (8e-16).","

InterPro
IPR005121
Domain

Ferredoxin-fold anticodon-binding
G3DSA:3.30.70.380	$\"[1-33]T$	Fdx_AntiC_bd
PF03147	$\"[1-39]T$	FDX-ACB
SSF54991	$\"[1-39]T$	Fdx_AntiC_bd

","BeTs to 6 clades of COG0072COG name: Phenylalanyl-tRNA synthetase beta subunitFunctional Class: JThe phylogenetic pattern of COG0072 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu May 2 11:47:44 2002","Thu May 2 11:47:44 2002","Tue Mar 12 14:28:14 2002","Tue Mar 12 14:28:14 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1367 is paralogously related (blast p-value < 1e-3) to SMu1372, a predicted phenylalanyl-tRNA synthetase (beta subunit).","Tue Mar 12 14:28:14 2002","","No significant hits to the NCBI PDB database.","SMU.1505c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 14:28:14 2002","24379895","","","","","","1","","","SMU.1505c","" "SMu1368","1432515","1431235","1281","ATGAGTTATTCTAAAGAGGTGAACCGTTATGTTTTTCCTCTCGTTGCCACAAACCTTGTTCAAGTTTTGATTGGTCAAATTTCTCTTCATTTTGCTGTCGATAATTCTAATGCTGCCTTGTCTGGCATTTCTGTTATCCAGAATTTTCTTTTTGCATTTGGAGGTATTCTTGGAGCCTTTAGTTTGTCGTTTAATATTAGAGGTGCCAAGGCTTTTTATAATAAAGAATACCAACGATTTAAAAATCTTTTAAAATCATCCCTGCTAATTGATATTGGAATTGGACTGTCATTCATTCTTTTTTGTCTGGGATTGAGCAGACCTTTTTTGAAAGTTTTTTATGGTTTTGATGGTCAATTATTGGAACTATCGACTACCTATTTTAAGATCATGTCTCCTTATATTTTATTGACCTTATTAATCTTTCTTTTTTCAAATCTTTTGAAAATTGAGAAGAAAACAAAGCCCATTTTTTGGATTGGAACCCTAAGTTCCGTGCTAGATGTCTTGTTAAACTATTACTTAGTTCCTCTTTTGGGAATTCGTGGAGCTGCTATTTCGTCTATTTTATCGCTGCTAGTCATTGTTTTAGGGTATTTCATTTTTGTAAAATCTCTTGTTTTTCAAGCGCTTCAAGAGGCTTCGACAAGTAAGTTAGAGCTTATCCGTTTTGGAATTCCTTTATCCATACAAGAAATACTGGAGAGTGTTTTATTTATCATGGCTTTCGACGCTTTCATGGGAAGACAAGGGCTACGCATTTTGTCCATCTATGCGGTAGTCAGTCAATTATTTGCAATTGTGAGAACACCTGCCTTTATGTATGCGGGTTCAATAGCAATCTTTTTGCCTGAAGCTAGGAAAAAAGAAGACGAAAAAGCATTGATTGCAACTATTTTTAGAAATAGCTACGCTGTTATATTTATATTTGCTTGTTTAGTAACAGTATTTTCAAATCCTTTTGCTCATTTTTTGTCTGATGAAGTTATTGATAATGTGCTGCCTTTTACTTTGTACACGGTTGTGGTCATGGGAGCAACACCTCTATATGAAAGCTCTAAGATGCTTTTGCAAAGCAATGATGACGAACAATGGGTTTTAAAAATAACAAGCATTGTCAATATATTAAGTATCCTTATCTTATTAGTTCTCCAGTTAATGGGCAAGCAAACCTATCAATCTCTGTATGGCATTTATGGTTTGAGTTTAATAGTGCTTAGTATTCTTTTCATAAAAAGAAATAGTGAGAAGAGAGTATCATCACGTAAAATGACAATGTAA","10.30","11.39","47824","MSYSKEVNRYVFPLVATNLVQVLIGQISLHFAVDNSNAALSGISVIQNFLFAFGGILGAFSLSFNIRGAKAFYNKEYQRFKNLLKSSLLIDIGIGLSFILFCLGLSRPFLKVFYGFDGQLLELSTTYFKIMSPYILLTLLIFLFSNLLKIEKKTKPIFWIGTLSSVLDVLLNYYLVPLLGIRGAAISSILSLLVIVLGYFIFVKSLVFQALQEASTSKLELIRFGIPLSIQEILESVLFIMAFDAFMGRQGLRILSIYAVVSQLFAIVRTPAFMYAGSIAIFLPEARKKEDEKALIATIFRNSYAVIFIFACLVTVFSNPFAHFLSDEVIDNVLPFTLYTVVVMGATPLYESSKMLLQSNDDEQWVLKITSIVNILSILILLVLQLMGKQTYQSLYGIYGLSLIVLSILFIKRNSEKRVSSRKMTM","1431250","","conserved hypothetical protein","Membrane, Cytoplasm","Numerous matches in gapped BLAST to conserved hypotheticals and to different kinds of proteins. Residues 5-315 are 20% similar to a damage-inducible protein from Pyrococcus abyssi(gi|14520582|).Residues 5-257 are 20% similar to a conserved hypothetical protein from Thermotoga maritima (gi|15643578|) SMu1368 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002528
Family

Multi antimicrobial extrusion protein MatE
PTHR11206	$\"[27-344]T$	MatE
PF01554	$\"[13-174]T$ $\"[227-384]T$	MatE

","BeTs to 8 clades of COG0534COG name: Probable cation efflux pump (multidrug resistance protein)Functional Class: RThe phylogenetic pattern of COG0534 is amtKYqVCEBrhUJgpOl---Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:37:41 2002","Tue Mar 12 14:34:34 2002","Tue Mar 12 14:34:34 2002","Tue Mar 12 14:34:34 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1368 is paralogously related (blast p-value < 1e-3) to SMu0064, a predicted MATE efflux family protein.","Tue Mar 12 14:34:34 2002","","No significant hits to the NCBI PDB database.","SMU.1506c","","Residues 13 to 174 (E-value = 1.4e-10) place SMu1368 in the MatE family which is described as MatE (PF01554)","Tue Mar 12 14:34:34 2002","24379896","","","","","","1","","","SMU.1506c","" "SMu1369","1432835","1432512","324","ATGAAAAATCATTTTACAATAAAAGGGAAGAGAGATTTTGTTGTTGATAAAATTGACGATGAGTTTATAGGATATGATAGATTAGATCTAGAGTATTATTCTTTTGATGATATAGGTGCTGAAATTTTATATTGTATTTCTAAAAACTTTTCTTTGGACAAAATCATTGAGGTCATTCAAGAAGAGTATGATGTGACTTATGACGATTGTAAGAAAGCTATTGTCCATTTTTTAGAGGAGACACCTATATTACATATTATTTATGCAAATCTTATTAAATCAGACATTTATTTATACCTAAAACCATTTCGGGAGGCATTATGA","4.50","-8.38","12754","MKNHFTIKGKRDFVVDKIDDEFIGYDRLDLEYYSFDDIGAEILYCISKNFSLDKIIEVIQEEYDVTYDDCKKAIVHFLEETPILHIIYANLIKSDIYLYLKPFREAL","1432527","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1369 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:37:10 2002","Tue Mar 12 14:35:59 2002","Tue Mar 12 14:35:59 2002","Tue Mar 12 14:35:59 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1369 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:37:10 2002","","No significant hits to the NCBI PDB database.","SMU.1507c","","No significant hits to the Pfam 11.0 database","Tue Mar 12 14:35:59 2002","24379897","","","","","","1","","","SMU.1507c","" "SMu1370","1433947","1432832","1116","ATGAGAGATTATTCACCATATCCGTTATTGGTTGATGTTTGTGTAACAAATCGTTGTAATTTAAGTTGTTCATATTGTTCAGCAGAAGCAGGCCCTTTTGCCAGTAAAAAAGGAGAGATGTCTGTTGAGAAGCTGGATTCTATTTTCCGTGAATTAAATTTAATGGGAGTTCCGCGAGTAGGTGTTACTGGAGGTGAACCGTTTATTAGAGATGATATATTAGACATCTTAAAGGCTTTTGATAAATATCATTTTGCTAAAGTTTTAAATACTAATGGTAACCTCATTACAGATTCTGTAGCTAAGGAATTATCTAAACTGCATTTGGATAGAATTTGTGTGACTGTGGATGGAAGTTGCTCTAAAGTTCATGATAGCCAAAGAGGTAAAGGAAGCTTTAAAAAGGCAATAGAGGGTATTAAAAATTTACAAAGGTATAATCTTCCTGTTTCTACACTTTTTACATTAGGAAGGCACAATGTAGATGATTTGATTAACACTATTAGGTTAAACGATATGCTTAGAATTAAATATATGTCTGTAATGATTATTTGCCCAACAGGTAGAGCTAATAATGGAAGCATTCTAGCAGATAAGAAACATTGGTATCCTGTATTTTTAGATTTAACAGAGAGATTGTCTCGTGGAGAATTTAAAGTGAAGTTTAAAATAGTTCCTCCAAATGAAAGTGATGTCTTTTGGACACATTATTTCCCACTAGCTTTTTACAACCGATTAGATTTACTTGAAAGTGTATGGCATCAAAGCCTGAACTTTAATAGTAACAAGAAAAGAGAAATATCTTGCCAAGCTGGAGTAAGAGCTTGTTCTATCAACCATAAAGGTGATGTTTATGGTTGTGATTTGATGAACGGCATTGATGAACTTGTAGCAGGTAATGTAAAAGAAAAATCTTTTTATGAAATTTGGCATAATTCTTCTATATTTCATAAATTGAGAAATATTACATTTGACGATATTTCGGGGAAATGTGCTGGTTGCCCCTTACCTTGGTGTGGTGGTGGATGTAGATGCAGTGCACTGGAGTTAGATGGAACTTTGCTTGGATCTGATTTAGCATGTTTTTATGATGAAGAGGAAAGCGTATTGGTATGA","7.30","1.66","41713","MRDYSPYPLLVDVCVTNRCNLSCSYCSAEAGPFASKKGEMSVEKLDSIFRELNLMGVPRVGVTGGEPFIRDDILDILKAFDKYHFAKVLNTNGNLITDSVAKELSKLHLDRICVTVDGSCSKVHDSQRGKGSFKKAIEGIKNLQRYNLPVSTLFTLGRHNVDDLINTIRLNDMLRIKYMSVMIICPTGRANNGSILADKKHWYPVFLDLTERLSRGEFKVKFKIVPPNESDVFWTHYFPLAFYNRLDLLESVWHQSLNFNSNKKREISCQAGVRACSINHKGDVYGCDLMNGIDELVAGNVKEKSFYEIWHNSSIFHKLRNITFDDISGKCAGCPLPWCGGGCRCSALELDGTLLGSDLACFYDEEESVLV","1432847","","coenzyme PQQ synthesis protein /possible oxidoreductase","Cytoplasm","Weak matches in gapped BLAST to MoaA/NirJ family Fe-S oxidoreductase and to coenzyme PQQ synthesis protein: residues 9-367 are 27% similar to MoaA/NirJ family Fe-S oxidoreductase and residues 15-364 are 30% similar to coenzyme PQQ synthesis protein from Aeropyrum pernix (gi14601538). SMu1370 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000385
Domain

MoaA/nifB/pqqE, iron-sulphur binding
PS01305	$\"[15-26]T$	MOAA_NIFB_PQQE

InterPro
IPR006638
Domain

Elongator protein 3/MiaB/NifB
SM00729	$\"[9-211]T$	Elp3

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[13-171]T$	Radical_SAM

noIPR
unintegrated

unintegrated
SSF102114	$\"[7-336]T$	SSF102114

","BeTs to 11 clades of COG0535COG name: Molybdenum cofactor biosynthesis enzyme and related Fe-S oxidoreductasesFunctional Class: H,RThe phylogenetic pattern of COG0535 is AMTK-QVCeBRhuj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 269-367 are 31% similar to a (PROTEOME COMPLETE COENZYME SYNTHESIS) protein domain (PD004964) which is seen in O27813_METTH.Residues 15-77 are 38% similar to a (COFACTOR BIOSYNTHESIS PROTEOME COMPLETE) protein domain (PD094266) which is seen in MOAA_METTH.Residues 13-117 are 27% similar to a (BIOTIN SYNTHASE SYNTHETASE IRON-SULFUR) protein domain (PD003026) which is seen in MOAA_METJA.Residues 13-150 are 29% similar to a (PROTEOME COMPLETE OXIDASE III COPROPORPHYRINOGEN) protein domain (PD000690) which is seen in MOAA_BACSU.Residues 63-170 are 29% similar to a (COMPLETE PROTEOME COFACTOR BIOSYNTHESIS MOLYBDENUM) protein domain (PD000790) which is seen in Q9JN48_ACICA.Residues 269-365 are 38% similar to a (COMPLETE PROTEOME 552AA ASTB/CHUR-RELATED) protein domain (PD293603) which is seen in O58557_PYRHO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:36:45 2002","Thu Mar 1 12:26:58 2007","Thu Mar 1 12:26:58 2007","Tue Mar 12 14:41:18 2002","","Tue Mar 12 14:41:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1370 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:36:45 2002","","No significant hits to the NCBI PDB database.","SMU.1508c","","Residues 13 to 171 (E-value = 5.6e-29) place SMu1370 in the Radical_SAM family which is described as Radical SAM superfamily (PF04055)","Tue Mar 12 14:41:18 2002","24379898","Thu Mar 1 12:26:58 2007","","","","","1","","","SMU.1508c","" "SMu1371","1435010","1434153","858","ATGACTGAATATGGAAAAATATTTAAAAAATTTAGAGAATCACGCGGTCTAAAAATGAAGGAAGTAGCTGGTTCAAATTTATCAACTTCACATCTTTCAAGATTTGAAAATGGAGAATCTGAGCTGACAATAAGTAAACTTATGACAGCACTGTACAAAATAAATATGCCTATTGAAGAATTTATGTATGCTGCCAATGATTTCCATCAGGATGAATTAAATGAGCTCCTTAAAGATGTGAGGGAGTGTGTTAATAATAAAGATGTTGAACGATTAAAAGCGGTATTGATTAAGCAACAAGAGAATTTAAAAGAAGGTCGAATTTTTCACCATTTGAATGTTATTCTAGTAAAAATAAGGTTGCAAGATTTATCCGGTGAAACTTATTATAGTAAAGCAGACCTAGATTACTTAACAAATTACTTATTTAAAGTTGAATACTGGGGTTTCTATGAGCTGTTACTTTTTACGAATACTATTGATGTTTTTAAACATGAAACTTTTATGGTTCTCTCTAGAGAGATGATGAGACGGTCAGATTTTTATAAAGAAATACCTCGAAATCGACGTCTTATTTCACGTATGGCTCTGAATTCTTTTATAACTTGCATTGAAAGAGATAAACTGATTGATGCACTGTATTTTGAAAAACAATTAAGCATCTGTCATTTTGATGAAACAGAAATTTATGAACGCTTGGTCTTTCATTATGCTCAAAATCTATTTGCCTATAAAAAATATAAGACGACATTTGCTATTATTGAAATGAAGAAATCAGTAGCAGCAATGAAATTGGCAGGGAGTTTGCATATTGCTGAAACCTATGAAAACCATCTTCAAAAAATTTTAGAAGGATAA","8.00","3.05","33886","MTEYGKIFKKFRESRGLKMKEVAGSNLSTSHLSRFENGESELTISKLMTALYKINMPIEEFMYAANDFHQDELNELLKDVRECVNNKDVERLKAVLIKQQENLKEGRIFHHLNVILVKIRLQDLSGETYYSKADLDYLTNYLFKVEYWGFYELLLFTNTIDVFKHETFMVLSREMMRRSDFYKEIPRNRRLISRMALNSFITCIERDKLIDALYFEKQLSICHFDETEIYERLVFHYAQNLFAYKKYKTTFAIIEMKKSVAAMKLAGSLHIAETYENHLQKILEG","1434168"," While Smu1371 and Smu0099 are similar to MI0001, a MutR, they are not embedded in a mutacin operon and therefore probably have a different transcriptional role.","transcriptional regulator","Cytoplasm","This sequence has been previouisly published in GenBank as gi4102023, gi5918757, gi9801995 and gi12082656 a predicted transcriptional regulator MutR in S.mutans.Numerous hits in gapped BLAST to transcriptional regulators: residues 4-282 are 31% similar to gi7684296 of S.oralis.Residues 1-284 are 31% similar to gi15903066 of S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0239 (5e-35).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[8-61]T$	HTH_3
SM00530	$\"[7-61]T$	HTH_XRE
PS50943	$\"[8-61]T$	HTH_CROC1

InterPro
IPR010057
Domain

Transcriptional activator Rgg/GadR/MutR, C-terminal
TIGR01716	$\"[63-285]T$	RGG_Cterm

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[3-63]T$	Lambda_like_DNA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-246 are 19% similar to a (PLASMID) protein domain (PD126552) which is seen in O50343_LACHE.Residues 5-215 are 34% similar to a (REGULATOR PROTEOME TRANSCRIPTION COMPLETE) protein domain (PD039813) which is seen in RGG_STRGC.Residues 4-201 are 25% similar to a (PROTEOME COMPLETE REGULATOR) protein domain (PD403282) which is seen in Q9CF12_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:08:17 2005","Wed Mar 13 08:52:04 2002","Wed Apr 27 10:49:00 2005","Wed Mar 13 08:43:19 2002","","Wed Mar 13 08:43:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1371 is paralogously related (blast p-value < 1e-3) to SMu0099, a predicted transcriptional regulator. Both Smu0099 and Smu1371 are similar to MI0001 from strain UA140.","Wed Apr 27 10:45:07 2005","","No significant hits to the NCBI PDB database.","SMU.1509c","","Residues 8 to 61 (E-value = 7e-06) place SMu1371 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Wed Mar 13 08:43:19 2002","","","","Sulavik,M.C., Tardif,G. and Clewell,D.B.Identification of a gene, rgg, which regulates expression ofglucosyltransferase and influences the Spp phenotype ofStreptococcus gordonii ChallisJ. Bacteriol. 174 (11), 3577-3586 (1992)PubMed: 1534326Vickerman MM, Minick PE, Mather NM.Characterization of the Streptococcus gordonii chromosomal region immediately downstream of the glucosyltransferase gene.Microbiology. 2001 Nov;147(Pt 11):3061-70.PMID: 11700356","Wed Apr 27 10:49:00 2005","Tue May 3 12:08:17 2005","1","","","SMU.1509c","" "SMu1372","1437626","1435221","2406","ATGTTAGTAAGTTATAAATGGTTGAAAGAATTAGTTGATATTGATGTACCTAGTCACGAATTGGCTGAAAAAATGTCAACAACAGGTATTGAAGTTGAAGGGGTAGACGTTCCAGCAGAAGGACTGTCAAAATTAGTCGTCGGTCATGTCCTTTCTTGTGAAGATGTTCCAGAAACGCATCTTCATCTTTGTCAGGTGGATACTGGCGAGGAAGAATCTCGTCAAATCGTTTGTGGAGCACCAAATATTACAGCTGGCATTAAAGTAATTGTTGCTCTTCCGGGAGCTCGTATTGCAGATAATTATAAGATTAAAAAAGGGAAAATCCGCGGTATGGAATCTCTGGGTATGATTTGCTCTCTGCAGGAGCTTGGTTTGCCGGACAGCATTATTCCTAAGGAGTATTCAGATGGCATTCAAATTTTGCCTGAAGATGCTGTGCCGGGTGAAAGTATCTTCCCTTATTTGGACTTAGATGATGAAATCATTGAGCTGTCTATCACACCTAACCGTGCAGATGCTTTATCCATGCGCGGTGTGGCTCATGAAGTAGCAGCGATTTATGATAAATCTGTTCATTTTGAAGATAAAGTCTTGACTGAAAGTGATAAGAAAGCAGCTGACCTTATCAAGGTAGCCATCGCTTCTGACAAGGTTTTGACTTACAAAGCGCGTGTGGTTGAAAATGTAACCATTAAACCAAGTCCACAGTGGTTGCAAAATCTGCTTATGAATGCTGGCATTCGGCCTATTAATAATGTGGTTGATGTGACCAATTATGTTCTTCTTTATTTTGGACAGCCTATGCATGCTTTTGATTTAGATAAGTTTGAAGGCAAGGATATTCTTGCACGTCAGGCAAAAGCTGGTGAGAAATTAGTAACACTTGATGGTGAAGCGCGTGATTTGATTGAAGAGGATCTTGTCATTACTGTAGCAGATAAACCAGTGGCACTTGCAGGTGTTATGGGTGGTGCTGCAACTGAAATTGATGCCTCTTCTAAAAATGTTGTCCTTGAAGCAGCCGTCTTTGATGGAAAATCAGTTCGTAAAACAAGCAGCCGTCTTAATCTGCGTTCCGAAAGTTCTTCACGTTTTGAAAAAGGTGTTAATTACGCTGATGTTGTTAAGGCACTTGATTTTGCTGCAGCAATGCTGACGGAATTGGCAGATGGAACAGTTCTCGCTGGTCAGGTCAGTGCAGGAGCAGTTCCGACAGATGATATTCAAGTATCCACTAGTCTGGATTATGTCAATGTTCGCTTAGGTACAGACTTAGTTTTCTCAGATATTGAAAGTGTTTTTGCTCGCCTTGGTTTTGGTCTTTCTGGCAATGACGAAAAATTCACGGTTTCTGTACCGCGTCGCCGTTGGGATATTAGCATTCAGGCGGATTTGGTCGAAGAAATCGCTCGTATTTATGGTTATGATAAATTACCGACAACACTGCCTGAAGCAGCAGGAACAGTTGGTGAATTGACCAAGACACAGAAATTACGTCGTAAGATAAGAAATTTGGCTGAAGGTAGTGGTCTTTCAGAAATTATTTCCTATGCCCTGACAACGCCTGAAAAGGCAGTTGCTTTTACACCAAATCCTACTAAAATAACAGAATTAATGTGGCCAATGACCGTTGATCGCTCAGCATTACGTCAAAATATCGTTTCTGGAATGCTAGATACCATTGCCTATAATGTAGCACGTAAGAGCAACAATCTAGCCCTATATGAAATTGGCAAAGTATTTGAGCAAACAGCGGATCCCAAAAAAGATTTGCCTAAGGAAATAGATACTTTTGCCTTTGCTCTGACAGGTTTAGTAACTGAAAAAGACTTTCAGACAGCAGCAACCCCAGTTGATTTCTTCTATGCTAAAGGTGTTCTGGAAGCTATTCTTGCTAAGCTTGAAATCACTGTTCAATTTGTTGCGACTAAAGAAATGGCTAATATGCATCCCGGACGTACAGCTTTGATTGAACGTGATGGTCAAGTTATCGGTTATCTTGGTCAAGTTCATCCGCAGACTGCTAAACTGTACGATATTCCAGAAACTTATGTAGCAGAAGTGAATCTTAATGCACTGGAAGCAGCTCTTAAATCGGATTTAGTCTTTGAAGATATCACTAAATTCCCAGCTGTTTCGCGCGATATTGCCCTGCTTCTTTCAGAAAAAGTGAGTCACCAAGATATTTTGGATGCTATTGCAGCCAGCGGTGTGAAACGTCTGATCAAGGTAAAACTCTTTGATGTTTATGCCGGTGAAAAACTAGGAGTAGGTAAGAAATCAATGGCCTACAGCCTGACTTTCCAAAATCCTAATGATAATCTCACAGATGAAGAAGTTGCCAAATACATGGAAAAAATCACTTCAGCCCTAACCGAAAAAGTTGGTGCTGAAGTGAGATAA","4.80","-28.67","87337","MLVSYKWLKELVDIDVPSHELAEKMSTTGIEVEGVDVPAEGLSKLVVGHVLSCEDVPETHLHLCQVDTGEEESRQIVCGAPNITAGIKVIVALPGARIADNYKIKKGKIRGMESLGMICSLQELGLPDSIIPKEYSDGIQILPEDAVPGESIFPYLDLDDEIIELSITPNRADALSMRGVAHEVAAIYDKSVHFEDKVLTESDKKAADLIKVAIASDKVLTYKARVVENVTIKPSPQWLQNLLMNAGIRPINNVVDVTNYVLLYFGQPMHAFDLDKFEGKDILARQAKAGEKLVTLDGEARDLIEEDLVITVADKPVALAGVMGGAATEIDASSKNVVLEAAVFDGKSVRKTSSRLNLRSESSSRFEKGVNYADVVKALDFAAAMLTELADGTVLAGQVSAGAVPTDDIQVSTSLDYVNVRLGTDLVFSDIESVFARLGFGLSGNDEKFTVSVPRRRWDISIQADLVEEIARIYGYDKLPTTLPEAAGTVGELTKTQKLRRKIRNLAEGSGLSEIISYALTTPEKAVAFTPNPTKITELMWPMTVDRSALRQNIVSGMLDTIAYNVARKSNNLALYEIGKVFEQTADPKKDLPKEIDTFAFALTGLVTEKDFQTAATPVDFFYAKGVLEAILAKLEITVQFVATKEMANMHPGRTALIERDGQVIGYLGQVHPQTAKLYDIPETYVAEVNLNALEAALKSDLVFEDITKFPAVSRDIALLLSEKVSHQDILDAIAASGVKRLIKVKLFDVYAGEKLGVGKKSMAYSLTFQNPNDNLTDEEVAKYMEKITSALTEKVGAEVR","1435236","For other 'phe' genes see SMu0713 (pheA); SMu1788 (pheT); SMu1178 (pheA); SMu1367 (pheT) and SMu1374 (pheS).For phenylalanyl-tRNA synthetase (beta subunit) see SMu1367.For phenylalanyl-tRNA synthetase (alpha subunit) see SMu1374.For probable phenylalanyl-tRNA synthetase,beta subunit see SMu1788. ","phenylalanyl-tRNA synthetase, beta subunit","Cytoplasm","Several matches in gapped BLAST to phenylalanyl-tRNA synthetase (beta subunit): residues 1-801 are 75% similar to the enzyme in S.pyogenes (gi15674815) and are 71% similar to the protein from S.pneumoniae (gi15900491).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0871 (0.0).","

InterPro
IPR002547
Domain

t-RNA-binding region
PF01588	$\"[45-151]T$	tRNA_bind
PS50886	$\"[39-153]T$	TRBD

InterPro
IPR004532
Family

Bacterial phenylalanyl-tRNA synthetase, beta subunit
TIGR00472	$\"[1-801]T$	pheT_bact

InterPro
IPR005121
Domain

Ferredoxin-fold anticodon-binding
G3DSA:3.30.70.380	$\"[710-795]T$	Fdx_AntiC_bd
PF03147	$\"[708-801]T$	FDX-ACB
SSF54991	$\"[702-801]T$	Fdx_AntiC_bd

InterPro
IPR005146
Domain

B3/4
PF03483	$\"[218-391]T$	B3_4

InterPro
IPR005147
Domain

tRNA synthetase, B5
G3DSA:3.30.56.20	$\"[408-481]T$	B5
PF03484	$\"[408-476]T$	B5

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[407-481]T$	Putativ_DNA_bind

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[38-159]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[494-695]T$	G3DSA:3.30.930.10
G3DSA:3.50.40.10	$\"[197-406]T$	G3DSA:3.50.40.10
PTHR10947	$\"[1-801]T$	PTHR10947
SSF50249	$\"[35-185]T$	Nucleic_acid_OB
SSF55681	$\"[472-697]T$	SSF55681
SSF56037	$\"[197-405]T$	SSF56037

","BeTs to 17 clades of COG0072COG name: Phenylalanyl-tRNA synthetase beta subunitFunctional Class: JThe phylogenetic pattern of COG0072 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 222-303 are 46% similar to a (SYNTHETASE BETA LIGASE CHAIN) protein domain (PD400842) which is seen in SYFB_THEMA.Residues 307-401 are 51% similar to a (SYNTHETASE BETA CHAIN LIGASE) protein domain (PD217334) which is seen in Q9CEB5_LACLA.Residues 123-297 are 62% similar to a (SYNTHETASE BETA CHAIN LIGASE) protein domain (PD351643) which is seen in Q9CEB5_LACLA.Residues 1-120 are 35% similar to a (BETA LIGASE CHAIN SYNTHETASE) protein domain (PD249711) which is seen in SYFB_DEIRA.Residues 46-121 are 75% similar to a (SYNTHETASE BETA CHAIN LIGASE) protein domain (PD009777) which is seen in Q9CEB5_LACLA.Residues 1-45 are 69% similar to a (SYNTHETASE PROTEOME BETA COMPLETE) protein domain (PD378278) which is seen in Q9CEB5_LACLA.Residues 414-685 are 50% similar to a (SYNTHETASE BETA CHAIN LIGASE) protein domain (PD003388) which is seen in Q9CEB5_LACLA.Residues 707-801 are 50% similar to a (SYNTHETASE LIGASE CHAIN ALPHA) protein domain (PD006935) which is seen in Q9CEB5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 14:11:24 2006","Thu Sep 28 14:11:24 2006","Tue Aug 1 12:27:57 2006","Wed Mar 13 08:59:03 2002","","Wed Mar 13 08:59:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1372 is paralogously related (blast p-value < 1e-3) to SMu1788, and SMu1367, both predicted phenylalanyl-tRNA synthetase, beta subunit.","Wed Mar 13 09:00:09 2002","Tue Aug 1 12:27:57 2006","pdb1PYSB Chain B, Phenylalanyl-Trna Synthetase From Thermus T... 350 3e-097","SMU.1510c","","Residues 45 to 151 (E-value = 4.4e-24) place SMu1372 in the tRNA_bind family which is described as Putative tRNA binding domain (PF01588)Residues 156 to 301 (E-value = 3.4e-81) place SMu1372 in the B3_4 family which is described as B3/4 domain (PF03483)Residues 408 to 476 (E-value = 4e-22) place SMu1372 in the B5 family which is described as tRNA synthetase B5 domain (PF03484)Residues 708 to 801 (E-value = 3e-28) place SMu1372 in the FDX-ACB family which is described as Ferredoxin-fold anticodon binding domain (PF03147)","Tue Aug 1 12:27:57 2006","","","","Brakhage,A.A., Wozny,M. and Putzer,H.Structure and nucleotide sequence of the Bacillus subtilisphenylalanyl-tRNA synthetase genesBiochimie 72 (10), 725-734 (1990)PubMed: 2127701Wipat,A., Carter,N., Brignell,S.C., Guy,B.J., Piper,K., Sanders,J., Emmerson,P.T. and Harwood,C.R.The dnaB-pheA (256 degrees-240 degrees) region of the Bacillussubtilis chromosome containing genes responsible for stressresponses, the utilization of plant cell walls and primarymetabolismMicrobiology 142 (Pt 11), 3067-3078 (1996)PubMed: 8969504","","Wed Mar 13 08:59:03 2002","1","","","SMU.1510c","98" "SMu1373","1438161","1437640","522","ATGTCACAGGTTGAAATTAGAAAAGTCAATCAAGATGAGCTTTCTTTGCTTCAGAAAATTGCTATTCAGACTTTTCGTGAAACCTTTGCTTTTGATAATACAGCAGAGCAGCTGCAAAACTTTTTTGACGAAGCTTATACTTTGTCCGTTTTAAAATTAGAATTAGATGATAAAGAATCAGAAACCTATTTTATTTTGATGTCCGGTAAAGCAGCGGGATTTTTGAAAGTGAACTGGGGCAGCTCTCAAACTGAGCAGGTACTAGAAGATGCATTTGAAATTCAACGTCTTTATATTTTGAAAGCTTATCAAGGTTTAGGTTTAGGAAAACAGCTTTTTGAATTTGCTTTAGAACGTGCGCAAATATCAGGCTTATCATGGGTTTGGCTGGGCGTTTGGGAAAAGAATGTTAAGGCCCAGTTATTGTATGCTAAATATGGATTTGAACAATTTTCTAAGCATTCTTTTTTTGTTGGTAACAAAGTGGATACGGATTGGTTGCTTAAAAAGTCTTTAAGTTAG","5.00","-3.76","20018","MSQVEIRKVNQDELSLLQKIAIQTFRETFAFDNTAEQLQNFFDEAYTLSVLKLELDDKESETYFILMSGKAAGFLKVNWGSSQTEQVLEDAFEIQRLYILKAYQGLGLGKQLFEFALERAQISGLSWVWLGVWEKNVKAQLLYAKYGFEQFSKHSFFVGNKVDTDWLLKKSLS","1437655","","acetyltransferase; possible transcriptional repressor","Cytoplasm","Limited matches in gapped BLAST to acetyltransferase and transcriptional repressors : residues 6-172 are 65% similar to acetyltransferase, GNAT family from S.pneumoniae (gi|15900490|). Residues 4-172 are 36% similar to transcriptional regulator from B.subtilis (gi|16080268|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0870 (1e-61).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[63-149]T$	Acetyltransf_1
PS51186	$\"[4-173]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[4-172]T$	G3DSA:3.40.630.30
PTHR23091	$\"[26-152]T$	PTHR23091
PTHR23091:SF1	$\"[26-152]T$	PTHR23091:SF1
SSF55729	$\"[4-172]T$	SSF55729

","BeTs to 9 clades of COG0454COG name: Predicted acetyltransferasesFunctional Class: RThe phylogenetic pattern of COG0454 is AmTKYqVCEBR-uj----in-Number of proteins in this genome belonging to this COG is 8","No significant hits to the Blocks database.","Residues 70-173 are 43% similar to a (COMPLETE PROTEOME TRANSFERASE) protein domain (PD350597) which is seen in Q9K8D0_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 13 10:37:51 2002","Wed Mar 13 09:06:46 2002","Thu Oct 17 16:21:09 2002","Wed Mar 13 09:06:46 2002","","Wed Mar 13 09:06:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1373 is paralogously related (blast p-value < 1e-3) to SMu0349, a predicted ribosomal-protein-alanine transferase and SMu1269, a predicted conserved hypothetical; possible acetyltransferase.","Wed Mar 13 10:37:51 2002","","No significant hits to the NCBI PDB database.","SMU.1511c","","Residues 63 to 149 (E-value = 5.1e-14) place SMu1373 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Wed Mar 13 09:06:46 2002","24379901","","","","","","1","","","SMU.1511c","792" "SMu1374","1439277","1438234","1044","ATGGATTTACAAGCACAATTAGAAGAGCTGAGAAAATCAACTCAAGCAACATTAAAGGAAATGAGCGGCAATCACAGCAAAGAATTACAAGATTTGCGTGTTAAGGTTTTGGGTAAGAAAGGTTCCTTGACAGAACTTTTAAAAGGTCTAAAGGACTTACCAAATGAGTTGCGTCCTGTTGTTGGAAAACAAGTCAATGAAGTCCGTGATGTCTTAACAAAGGCTTTTGAAGAACAAGCTAAAATCGTTGAAGCCGCCAAAATTCAAGCGCAATTAGAATCAGAAACATTAGATGTCACTCTTCCGGGACGCCAAATACATCTAGGCAATCGCCATGTTCTCAGTCAGATAAGTGAAGAAATTGAAGATATATTCCTAGGAATGGGTTTTCAAGTGGTTGATGGCTATGAAGTTGAACAAGACTATTACAATTTCGAACGCATGAATTTGCCCAAAGATCACCCAGCACGTGATATGCAGGACACGTTTTATATTTCTGAAGACATTTTGCTTCGGACACATACCAGTCCTGTGCAGGCACGTACTTTAGATAAACATGATTTTTCTAAAGGACCGCTTAAGATGATTTCACCCGGGCGCGTTTTTCGCCGCGATACAGATGATGCGACGCATTCCCATCAATTCCATCAAATTGAAGGCTTGGTTGTTGGTAAAAACATTTCTATGGGTGACCTCAAAGGAACACTGGAAATGATTAGTAAAAAAATGTTTGGTGAAGATCGTAAGATTCGTCTGCGTCCTTCTTATTTCCCATTTACGGAGCCTTCTGTTGAAGTCGATGTTTCGTGTTTCAAATGCGGCGGCAAAGGCTGTAATGTTTGTAAGAAAACAGGTTGGATTGAAATTCTTGGTGCCGGTATGGTTCATCCAAGTGTTCTTGAAATGTCTGGCGTTAATTCTGAAGAATATTCTGGTTTTGCCTTTGGCTTAGGCCAAGAACGTATGGCTATGCTGCGCTATGGAATCAATGATATTCGAGGTTTCTATCAAGGTGACAGCCGTTTTACAGAACAATTCAATTAA","6.20","-4.75","39284","MDLQAQLEELRKSTQATLKEMSGNHSKELQDLRVKVLGKKGSLTELLKGLKDLPNELRPVVGKQVNEVRDVLTKAFEEQAKIVEAAKIQAQLESETLDVTLPGRQIHLGNRHVLSQISEEIEDIFLGMGFQVVDGYEVEQDYYNFERMNLPKDHPARDMQDTFYISEDILLRTHTSPVQARTLDKHDFSKGPLKMISPGRVFRRDTDDATHSHQFHQIEGLVVGKNISMGDLKGTLEMISKKMFGEDRKIRLRPSYFPFTEPSVEVDVSCFKCGGKGCNVCKKTGWIEILGAGMVHPSVLEMSGVNSEEYSGFAFGLGQERMAMLRYGINDIRGFYQGDSRFTEQFN","1438249","For other 'phe' genes see SMu0713 (pheA); SMu1788 (pheT); SMu1178 (pheA); SMu1367 (pheT) and SMu1372 (pheT ).For phenylalanyl-tRNA synthetase (beta subunit) see SMu1367. For phenylalanyl-tRNA synthetase (beta subunit) see SMu1372. For probable phenylalanyl-tRNA synthetase,beta subunit see SMu1788. ","phenylalanyl-tRNA synthetase, alpha subunit","Cytoplasm","Several matches in gapped BLAST to phenylalanyl-tRNA synthetase (alpha subunit): residues 1-347 are 83% similar to the enzyme in S.pyogenes (gi15674815) and residues 3-346 are 74% similar to the protein from S.pneumoniae (gi15900489). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0869 (1e-170).","

InterPro
IPR002319
Family

Phenylalanyl-tRNA synthetase, class IIc
PTHR11538	$\"[92-346]T$	tRNA-synt_2d
PF01409	$\"[96-346]T$	tRNA-synt_2d

InterPro
IPR004188
Domain

Aminoacyl tRNA synthetase, class II, N-terminal
PF02912	$\"[21-93]T$	Phe_tRNA-synt_N

InterPro
IPR004529
Family

Phenylalanyl-tRNA synthetase, alpha subunit
TIGR00468	$\"[42-347]T$	pheS

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[113-337]T$	AA_TRNA_LIGASE_II

InterPro
IPR010978
Domain

tRNA-binding arm
SSF46589	$\"[17-104]T$	tRNA_binding_arm

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[12-346]T$	G3DSA:3.30.930.10
SSF55681	$\"[96-347]T$	SSF55681

","BeTs to 17 clades of COG0016COG name: Phenylalanyl-tRNA synthetase alpha subunitFunctional Class: JThe phylogenetic pattern of COG0016 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 109-166 are 43% similar to a (SYNTHETASE ALPHA CHAIN LIGASE) protein domain (PD413351) which is seen in Q9HMK4_HALN1.Residues 231-346 are 71% similar to a (SYNTHETASE LIGASE CHAIN ALPHA) protein domain (PD006935) which is seen in Q9CEB4_LACLA.Residues 6-70 are 52% similar to a (SYNTHETASE ALPHA CHAIN LIGASE) protein domain (PD409709) which is seen in Q9CEB4_LACLA.Residues 95-225 are 78% similar to a (SYNTHETASE LIGASE ALPHA CHAIN) protein domain (PD002080) which is seen in Q9CEB4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 13:18:18 2006","Mon Sep 11 13:17:05 2006","Mon Sep 11 13:17:05 2006","Wed Mar 13 11:02:12 2002","","Wed Mar 13 11:02:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1374 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 13 11:02:12 2002","Mon Sep 11 13:17:05 2006","pdb1EIYA Chain A, The Crystal Structure Of Phenylalanyl-Trna ... 266 2e-072","SMU.1512c","","Residues 21 to 93 (E-value = 4.7e-31) place SMu1374 in the Phe_tRNA-synt_N family which is described as Aminoacyl tRNA synthetase class II, N-terminal domain (PF02912)Residues 113 to 333 (E-value = 2.5e-149) place SMu1374 in the tRNA-synt_2d family which is described as tRNA synthetases class II core domain (F) (PF01409)","Mon Sep 11 13:17:05 2006","","","","Brakhage,A.A., Wozny,M. and Putzer,H.Structure and nucleotide sequence of the Bacillus subtilisphenylalanyl-tRNA synthetase genesBiochimie 72 (10), 725-734 (1990)PubMed: 2127701","","Wed Mar 13 11:02:12 2002","1","","","SMU.1512c","334" "SMu1375","1443254","1439718","3537","ATGTTTTTAAAAGAAATTGAAATGCAGGGATTTAAATCTTTTGCTGATAAGACCAAGGTTGAGTTCGACAGAGGAGTGACAGCCGTTGTTGGACCAAATGGTTCAGGAAAGAGTAATATTACGGAGAGTTTACGCTGGGCTTTGGGTGAGTCAAGTGCCAAGAGCCTGCGTGGCGGTAAGATGCCAGACGTGATTTTTGCAGGAACTGAAAATCGAAAGCCACTCAATTACGCTCAAGTAACGGTTATTTTAGATAATAGCGATGCCTTTATCAAAGACGCTCAAGAGGAGATTCGCATTGAACGCCATATTTATCGTAATGGGGACAGTGATTATCTTATTGATGGTAAAAAAGTACGCCTGCGCGATATTCACGATTTGTTTATGGATACTGGTTTGGGGCGTGATTCCTTTTCCATTATTTCTCAAGGACGTGTGGAAGAGATTTTTAATAGTAAACCAGAAGAGCGTCGTTCAATTTTTGAAGAAGCAGCCGGTGTCTTAAAATACAAAACACGTAAAAAAGAGACGCAGTCTAAGCTAACACAGACTCAGGATAATTTGGATCGGCTGGATGATATTATCTATGAACTGGAGACACAGATAAAGCCTTTAGAACGTCAGGCAAAAACAGCCAAAGAATTTCTGGTTTTGGAAACAGAACGCAAGGAGAAACAGTTAGACTTGCTGGTCTACCAAATTCTCCATCATAAGGAAGCCTTAGTGAAAAACCAAGCTGAGCTTGAAAAAGTTAAACAAAATTTAGCAGCCTATTATCAAGAACGTGATCTATTAGAAACTAAGAATCAGACTCTAAAAGAAAAAAGGCACCAGCTTTCTCGTCAAATGGATCAAAAGCAGGCTGATCTCCTTGAAATGACACGTCTCATTAGTGATTACGAGCGTCAGATTGAACGCATTCATTTAGAGGTCAGTCAAAAGACAGAAAAGAAGCAATCTACTCAAAAAAGCCTAGAACAATTGTCAGAGCAAAAGGCTTCTCTTAAAACAGAATTAGCTCAAAAAGAAGTTGACTTAGAACAATTAGAAGAGGATCTTAAACAAAAAAATCAAGAAATTAAAAATGTCGAAACGGAATTGTCACGTTTTGCAACAGATCCTGATCATATTATTGAAAGTTTACGAGAAGATTTTGTTAGACTCATGCAAAAAGAGGCTGATACTTCTAACCAATTGGCTGTTTTAAAAGCAGAAATGGATAGTCGAAAGCAAGAATCCGAAAGTAAAACAGCAGAAATCAAACAAGTACAAGCAGACTTAGAGAAAGCAAAAGATCGAGAACAAAGGGAATCCGCAAACTTTGAAACTGCTAAAACCAAAGTTCAAGAATTGCTAAAGGACTATCAAAAAACAGCACAGCTTGTTCAGAATTTAGAAGCTGCTTATGCTGAGCAGCAAGAGGCTATGTTTCAATTGTTGGATGATGTCAAAGACAAGAAAGCACGCCAAAGCAGTCTGAAGTCCATCTTAAAAAGCCATAGTAATTTCTATGCAGGTGTTAGGTCTGTTCTTCAGCAGGCTGATAAAATTAAAGGTATTGTTGGCGCGGTTAGTGAACATTTAACTTTTGATAAAAAATATCAAACCGCACTTGAGATTGCCTTAGGTGCCAGCAGTCAAAATATTATTGTCGAAGATGAAGCGGCGGCCAAACGATCTATTGATTTTTTAAAGAAGAACCATCAAGGTCGAGCAACTTTTCTTCCTTTAACAACCATTAAACCCCGTCGTTTATCTGAGTCAAATCAAAGCCTATTAACTTCCAGCCAGGGCTTTCTCGGTTTAGCACGTGATTTGGTAAGTTTTGAGCCTCGTTTGCAAACAATTTTTGGCAATTTACTGGGTGTCACAGCGATTTTTGATACGGTTGGTCATGCCAATCAGGCAGCTCGCCAGTTACGTTATCAAGTGCGTCTTGTGACATTAGATGGAACAGAGATCCGTCCCGGAGGGTCCTTTTCAGGAGGGACTAGCCGTCAAAATAATACAACTTTTATCAAGCCAGAACTGGATCATTTGACACAAGAGCTAGCGCTTTTAGAAGAAAAACAAGTTGAGCAGGAAAGAATAGTTGAAAAGACCAAGCAGGACTTGGAAGTGAAAAAAGCAGATCTTTTAGAATTAAGGGAAAAAGGAAATCAAGCCCGATTGGCTGAGCAAAAGGCTGAGATGGAGTATCAACAATCAGAGTCTCATTTACAAGAGCTGGTCTTGCTTTATACCCAATTAAAACAAACAAATCAGGCGGATCTCAATCGAGACTTAGAAAAAGACCAAGCACTTTTACAAGAAAAGCTGTATAAAATTGCTGATGACAAGGAAAAGCTCAATCAAGAGATTGCTCAAATCAAGGAAGATAAAGATAGTATTCAGCAAAAGACAGCTGCTTTAAGTCAACGACTCTCTTCTTTGCAACTTTCTGAGCGCGATTTGGCTAATACACAGAAATTTGAAAGAACGAATTTAAAACGTTTGGCAGAAGAATTAGCTGAATTGGAGCAAAATGAAGCTGGTATGATGCAACTTTTAGATAGCCAAGAAGAGGATTTGGATGAAAAACGTTTACCATCACTCAAACGGCAATTAGCAAACGCTCAGGCTAGAAAAACAGAGAGTGACCAAGAACTTGTCCGCTACCGTTTTGAACTGGAAGACTGTGAAGCACAGCTAGAAGAGGTTGAGACCAATCTCCTAAAAACTAATCAAAAGAATGAAGAGTTCATTCGTCAGCAAACGCAATTAGAAGCAAAAAGGGATCATTTATCCAATCAATTGCGCCGTTTTGCCAATAACTTGGCTGAAGATTATCAACTAAGCTTAGATGATGCTAAACAAGAGGCAGGACCGATTGAAAATCTAGAAGCTGCTCAAGCTCATTTAAGCCAATTGGAAAAGCAAATTAAGGGATTGGGACCGGTCAACCTTGACGCAATCGGTCAGTACGATGAAGTGTCTGAGCGTTTGCATTTCTTAAATAGTCAAAAAGATGACCTTGTTCACGCTAAGGAACTTCTCCTGAATACTATTCATGATATGGATGATGAGGTCAAGGCACGCTTTAAGACGACTTTTGAAGCTATTCGTGACAGTTTTAAGACGACCTTTACGCAGATGTTTGGCGGAGGAAGTGCTGACTTGCTTTTGACAGAAGGAGATCTCTTGATGACCGGTGTTGAAATTTCAGTGCAGCCGCCCGGCAAGAAGATTCAATCTCTCAATCTTATGTCTGGTGGTGAAAAGGCACTGTCTGCTTTGGCATTGTTATTTGCCATCATTCGTGTTAAAACCATTCCCTTTGTTATTTTGGATGAGGTTGAGGCTGCTCTTGACGAGGCCAATGTCAAGCGTTTTGGTGATTATCTGAATCGTTTTGATAAGTCCAGCCAGTTTATTGTGGTCACTCACCGTAAAGGCACCATGTCTGCTGCAGATAGTATATATGGGGTTACCATGCAGGAATCAGGTGTCTCTAAGATTATCTCTGTTAAGCTAAAAGAAGTCGAAAAGATATCTTAA","5.40","-24.24","134492","MFLKEIEMQGFKSFADKTKVEFDRGVTAVVGPNGSGKSNITESLRWALGESSAKSLRGGKMPDVIFAGTENRKPLNYAQVTVILDNSDAFIKDAQEEIRIERHIYRNGDSDYLIDGKKVRLRDIHDLFMDTGLGRDSFSIISQGRVEEIFNSKPEERRSIFEEAAGVLKYKTRKKETQSKLTQTQDNLDRLDDIIYELETQIKPLERQAKTAKEFLVLETERKEKQLDLLVYQILHHKEALVKNQAELEKVKQNLAAYYQERDLLETKNQTLKEKRHQLSRQMDQKQADLLEMTRLISDYERQIERIHLEVSQKTEKKQSTQKSLEQLSEQKASLKTELAQKEVDLEQLEEDLKQKNQEIKNVETELSRFATDPDHIIESLREDFVRLMQKEADTSNQLAVLKAEMDSRKQESESKTAEIKQVQADLEKAKDREQRESANFETAKTKVQELLKDYQKTAQLVQNLEAAYAEQQEAMFQLLDDVKDKKARQSSLKSILKSHSNFYAGVRSVLQQADKIKGIVGAVSEHLTFDKKYQTALEIALGASSQNIIVEDEAAAKRSIDFLKKNHQGRATFLPLTTIKPRRLSESNQSLLTSSQGFLGLARDLVSFEPRLQTIFGNLLGVTAIFDTVGHANQAARQLRYQVRLVTLDGTEIRPGGSFSGGTSRQNNTTFIKPELDHLTQELALLEEKQVEQERIVEKTKQDLEVKKADLLELREKGNQARLAEQKAEMEYQQSESHLQELVLLYTQLKQTNQADLNRDLEKDQALLQEKLYKIADDKEKLNQEIAQIKEDKDSIQQKTAALSQRLSSLQLSERDLANTQKFERTNLKRLAEELAELEQNEAGMMQLLDSQEEDLDEKRLPSLKRQLANAQARKTESDQELVRYRFELEDCEAQLEEVETNLLKTNQKNEEFIRQQTQLEAKRDHLSNQLRRFANNLAEDYQLSLDDAKQEAGPIENLEAAQAHLSQLEKQIKGLGPVNLDAIGQYDEVSERLHFLNSQKDDLVHAKELLLNTIHDMDDEVKARFKTTFEAIRDSFKTTFTQMFGGGSADLLLTEGDLLMTGVEISVQPPGKKIQSLNLMSGGEKALSALALLFAIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKSSQFIVVTHRKGTMSAADSIYGVTMQESGVSKIISVKLKEVEKIS","1439733","","chromosome segregation SMC protein","Cytoplasm","Several matches in gapped BLAST to chromosome condensation and segregation SMC protein: residues 1-1178 are 58% similar to the protein in S.pyogenes (gi|15674632|). Residues 1-1177 are 56% similar to the protein from S.pneumoniae (gi|15903169|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0724 (0.0).","

InterPro
IPR003395
Domain

SMC protein, N-terminal
PF02463	$\"[2-1165]T$	SMC_N

InterPro
IPR010935
Domain

SMCs flexible hinge
PF06470	$\"[517-637]T$	SMC_hinge

InterPro
IPR011890
Family

Chromosome segregation protein SMC
TIGR02168	$\"[2-1171]T$	SMC_prok_B

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-199]T$ $\"[992-1177]T$	G3DSA:3.40.50.300
PTHR18937	$\"[22-1177]T$	PTHR18937
PTHR18937:SF10	$\"[22-1177]T$	PTHR18937:SF10
SSF52540	$\"[1-1156]T$	SSF52540
SSF75553	$\"[479-685]T$	SSF75553

","BeTs to 12 clades of COG1196COG name: Chromosome segregation ATPasesFunctional Class: DThe phylogenetic pattern of COG1196 is am-kYqvc-br---gpol---Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 53-154 are 68% similar to a (CHROMOSOME PROTEOME COMPLETE ATP-BINDING) protein domain (PD002128) which is seen in Q9CHC9_LACLA.Residues 169-501 are 21% similar to a (DEVELOPMENTAL DG1113) protein domain (PD317004) which is seen in Q9U9K8_DICDI.Residues 420-529 are 25% similar to a (CHROMOSOME SMC COMPLETE PARTITION) protein domain (PD033192) which is seen in Q9KA07_BACHD.Residues 330-484 are 26% similar to a (Y26D4A.9) protein domain (PD305627) which is seen in Q9U2P7_CAEEL.Residues 197-490 are 20% similar to a (CALCIUM-BINDING REPEAT TRICHOHYALIN) protein domain (PD026728) which is seen in TRHY_RABIT.Residues 3-50 are 50% similar to a (DNA REPAIR ATP-BINDING RECOMBINATION) protein domain (PD348650) which is seen in Q59037_METJA.Residues 156-231 are 63% similar to a (CHROMOSOME COMPLETE PROTEOME SEGREGATION) protein domain (PD186735) which is seen in Q9CHC9_LACLA.Residues 487-530 are 56% similar to a (PROTEOME COMPLETE SEGREGATION CHROMOSOME) protein domain (PD377726) which is seen in Q9CHC9_LACLA.Residues 51-234 are 27% similar to a (PROTEOME ATP-BINDING COMPLETE COILED) protein domain (PD166937) which is seen in Q59037_METJA.Residues 531-663 are 54% similar to a (CHROMOSOME COILED ATP-BINDING SEGREGATION) protein domain (PD002134) which is seen in Q9CHC9_LACLA.Residues 177-472 are 23% similar to a (MOTOR ATP-BINDING MOLECULE COILED) protein domain (PD361016) which is seen in Q9U141_LEIMA.Residues 1-48 are 79% similar to a (DNA REPAIR REPLICATION ATP-BINDING) protein domain (PD000596) which is seen in Q9CHC9_LACLA.Residues 32-495 are 21% similar to a (CG1905) protein domain (PD327633) which is seen in Q9VYU0_DROME.Residues 238-429 are 22% similar to a (KINASE ATP-BINDING RHO-ASSOCIATED) protein domain (PD075247) which is seen in P92199_CAEEL.Residues 943-1027 are 58% similar to a (PROTEOME COMPLETE CHROMOSOME SEGREGATION) protein domain (PD328842) which is seen in Q9CHC8_LACLA.Residues 48-303 are 20% similar to a (PROTEOME COMPLETE P115) protein domain (PD137691) which is seen in O51074_BORBU.Residues 49-167 are 35% similar to a (PROTEOME COMPLETE P115) protein domain (PD396382) which is seen in Q9PR04_UREPA.Residues 1130-1171 are 71% similar to a (COMPLETE PROTEOME CHROMOSOME COIL) protein domain (PD164887) which is seen in SMC_BACSU.Residues 676-921 are 21% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in Q9CHC9_LACLA.Residues 155-247 are 34% similar to a (MYOSIN CHAIN HEAVY ATP-BINDING MUSCLE COIL COILED) protein domain (PD000023) which is seen in Q9RP51_CAUCR.Residues 1030-1125 are 68% similar to a (CHROMOSOME COILED ATP-BINDING COMPLETE) protein domain (PD001034) which is seen in Q9CHC8_LACLA.Residues 326-606 are 21% similar to a (MOTOR ATP-BINDING MICROTUBULES COIL) protein domain (PD321101) which is seen in Q9GQ58_STRPU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 13 11:12:41 2002","Wed Mar 13 11:07:24 2002","Thu Oct 17 16:16:05 2002","Wed Mar 13 11:07:24 2002","","Wed Mar 13 11:07:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1375 is paralogously related (blast p-value < 1e-3) to SMu0556, a predicted cell surface antigen I/II, SpaP protein precursor, pac protein precursor;saliva-interacting protein;PAGS-5; SMu0532, a predicted DNA repair and genetic recombination protein RecN; SMu1166,a predicted cell division regulator; SMu1306 and SMu1065, both predicted ABC transporters, ATP-binding protein; SMu0319 and SMu1060,both predicted conserved hypothetical proteins; SMu0676 , cell division protein FtsY; signal recognition particle (docking protein). ","Wed Mar 13 11:12:41 2002","Wed Mar 13 11:07:24 2002","pdb|1E69|A Chain A, Smc Head Domain From Thermotoga Maritima >g... 141 3e-034","SMU.1513c","","Residues 1 to 167 (E-value = 1.2e-74) place SMu1375 in the SMC_N family which is described as RecF/RecN/SMC N terminal domain (PF02463)Residues 517 to 664 (E-value = 5.9e-40) place SMu1375 in the SMC_hinge family which is described as SMC proteins Flexible Hinge Domain (PF06470)Residues 970 to 1171 (E-value = 6.2e-95) place SMu1375 in the SMC_C family which is described as SMC family, C-terminal domain (PF02483)","Wed Mar 13 11:07:24 2002","","","","Moriya,S., Tsujikawa,E., Hassan,A.K., Asai,K., Kodama,T.and Ogasawara,N.A Bacillus subtilis gene-encoding protein homologous to eukaryoticSMC motor protein is necessary for chromosome partitionMol. Microbiol. 29 (1), 179-187 (1998)PubMed: 9701812Britton,R.A., Lin,D.C. and Grossman,A.D.Characterization of a prokaryotic SMC protein involved inchromosome partitioningGenes Dev. 12 (9), 1254-1259 (1998)PubMed: 9573042","","Wed Mar 13 11:15:10 2002","1","","","SMU.1513c","75" "SMu1376","1443949","1443254","696","ATGAAAACATTAGAAAAAAAACTGGCAGAAGACTTTAAGATCGTCTTTTCTGACAAGGAATTATTGGAAACTGCCTTTACTCATACTAGTTATGCTAATGAGCATCGCCTCCTAAACATTTCACATAACGAGCGCTTGGAATTTTTAGGAGACGCTGTTCTGCAGTTAACGATTTCACATTATCTTTTTGACAAATACCCTCAAAAAGCTGAAGGTGATTTATCAAAAATGCGTTCGATGATTGTTCGTGAAGAAAGTTTGGCGGGTTTTTCTAGAAATTGTCACTTTGACCGCTATATTAAATTAGGTAAGGGTGAAGAAAAATCTGGCGGTCGTCAAAGAGATACTATTTTGGGCGATTTATTTGAGGCTTTTTTAGGTGCTCTTTTATTGGATGCAGGTCTTAAAGCTGTTGAGGCCTTTCTCAATCAAGTTGTGATTCCTAAGGTTGAAAATAATAATTATGAACGTGTTACCGATTATAAAACGGCACTTCAAGAATTATTGCAAGTTGACGGGGATGTTTTGATCGATTACGAGGTCTTAAAAGAATCAGGACCCGCCCATGCAAAATGCTTTGAAGTTGCTGTTTCTATGAATCATGAAAAACTTAGTAGCGGGACAGGCAAATCAAAAAAATTAGCAGAGCAAGAGGCTGCTAAAAATGCGCTTGAAAAACTTCAACGAGGTTCTTAA","6.20","-3.39","26014","MKTLEKKLAEDFKIVFSDKELLETAFTHTSYANEHRLLNISHNERLEFLGDAVLQLTISHYLFDKYPQKAEGDLSKMRSMIVREESLAGFSRNCHFDRYIKLGKGEEKSGGRQRDTILGDLFEAFLGALLLDAGLKAVEAFLNQVVIPKVENNNYERVTDYKTALQELLQVDGDVLIDYEVLKESGPAHAKCFEVAVSMNHEKLSSGTGKSKKLAEQEAAKNALEKLQRGS","1443269","For other 'acp' genes see SMu0023 (ACP),(acpP); SMu1589 (acp) and SMu1671 (acpS).","ribonuclease III","Cytoplasm","Several matches in gapped BLAST to ribonuclease III: residues 1-227 are 63% similar to the enzyme in S.pyogenes (gi|15674631|). Residues 1-226 are 61% similar to the protein from S.pneumoniae (gi|15903170|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0723 (5e-81).","

InterPro
IPR000999
Domain

Ribonuclease III
G3DSA:1.10.1520.10	$\"[3-153]T$	RNase_III
PF00636	$\"[44-134]T$	Ribonuclease_3
SM00535	$\"[20-155]T$	RIBOc
PS00517	$\"[44-52]T$	RNASE_3_1
PS50142	$\"[1-134]T$	RNASE_3_2
SSF69065	$\"[1-164]T$	RNase_III

InterPro
IPR001159
Domain

Double-stranded RNA binding
PF00035	$\"[161-227]T$	dsrm
SM00358	$\"[161-228]T$	DSRM
PS50137	$\"[160-229]T$	DS_RBD

InterPro
IPR011907
Family

Ribonuclease III, bacterial
TIGR02191	$\"[8-227]T$	RNaseIII

InterPro
IPR014720
Domain

Double-stranded RNA-binding-like
G3DSA:3.30.160.20	$\"[160-227]T$	dsRNA-bd-like

noIPR
unintegrated

unintegrated
PTHR11207	$\"[14-229]T$	PTHR11207
SSF54768	$\"[147-228]T$	SSF54768

","BeTs to 13 clades of COG0571COG name: dsRNA-specific ribonucleaseFunctional Class: KThe phylogenetic pattern of COG0571 is ----YqvCebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000999 (Ribonuclease III family) with a combined E-value of 4.3e-56. IPB000999A 21-30 IPB000999B 43-79 IPB000999C 116-134 IPB000999D 160-179 IPB000999E 185-195 IPB000999F 209-220","Residues 6-83 are 62% similar to a (III RIBONUCLEASE HYDROLASE ENDONUCLEASE) protein domain (PD002508) which is seen in RNC_LACLA.Residues 155-225 are 45% similar to a (RNA-BINDING III DOUBLE-STRANDED NUCLEAR HYDROLASE) protein domain (PD003300) which is seen in RNC_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 16:15:33 2002","Wed Mar 13 12:34:16 2002","Thu Oct 17 16:15:33 2002","Wed Mar 13 12:32:14 2002","Wed Mar 13 12:32:14 2002","Wed Mar 13 12:32:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1376 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 13 12:34:16 2002","","No significant hits to the NCBI PDB database.","SMU.1514c","","Residues 44 to 134 (E-value = 2.8e-47) place SMu1376 in the Ribonuclease_3 family which is described as RNase3 domain (PF00636)Residues 161 to 227 (E-value = 1.4e-23) place SMu1376 in the dsrm family which is described as Double-stranded RNA binding motif (PF00035)","Wed Mar 13 12:32:14 2002","","","","Nashimoto,H. and Uchida,H.DNA sequencing of the Escherichia coli ribonuclease III gene andits mutationsMolecular & general genetics : MGG. 201 (1), 25-29 (1985)PubMed: 3903434Takiff,H.E., Chen,S.M. and Court,D.L.Genetic analysis of the rnc operon of Escherichia coliJournal of bacteriology. 171 (5), 2581-2590 (1989)PubMed: 2540151","","Wed Mar 13 12:42:25 2002","1","","","SMU.1514c","541" "SMu1377","1444859","1444056","804","ATGACAGAAACAGGTTTTAGATACAGCATTCTGGCTTCTGGTTCAAGTGGCAATAGTTTTTATTTGGAAACTCCTCAAAAGAGAATTTTAATTGACGCAGGCCTCTCAGGTAAGAAAATTAGTCAATTAATGGCAGAAATAGACCGAAAAGTAGATGATGTTGATGCCATTTTAGTAACACATGAACATAAAGATCATATTCACGGTGTTGGTGTACTAGCTCGGAAATATGGTTTGGATGTCTATGCGAATGCAGCAACATGGCAAGCTATGGATGGCATGATTGGTAAAATTGATGTCAGCCAAAAACATATCTTTGATCTGGGGAAAACCATCACTTTTGGGGATATTGATATTGAAAGTTTTGGTGTCAGCCATGATGCTGCTCAACCACAGTTTTACCGCCTGATGAAAGACGGCAAGAGCTTTGTTATATTGACGGATACAGGTTATGTCAGTGATCGTATGGCAGATCTGATTGAAAATGCTGATGGTTATCTGATTGAGTCCAATCATGATATTGAAATTTTACGCTCAGGTATCTACCCTTGGAGTTTAAAACAGCGTATTTTATCCGATAAAGGACACCTATCAAATGATGATGGTGCAGAAACAATGGTTCGAACTTTGGGGAATAAAACAAAAAAGATTTATTTGGGACATCTCAGCAAAGAAAACAATGTCAAAGAATTAGCCCATATGACGATGAAGAATGCTCTCATGCAGGCAGATTTGGCTGTAGATCATGATTTTAAGATTTATGATACCTCGCCAGATACTGCTTTACCATTAGCAAAAATCTAG","6.10","-5.35","29680","MTETGFRYSILASGSSGNSFYLETPQKRILIDAGLSGKKISQLMAEIDRKVDDVDAILVTHEHKDHIHGVGVLARKYGLDVYANAATWQAMDGMIGKIDVSQKHIFDLGKTITFGDIDIESFGVSHDAAQPQFYRLMKDGKSFVILTDTGYVSDRMADLIENADGYLIESNHDIEILRSGIYPWSLKQRILSDKGHLSNDDGAETMVRTLGNKTKKIYLGHLSKENNVKELAHMTMKNALMQADLAVDHDFKIYDTSPDTALPLAKI","1444071","For other 'cov' genes see SMu1031 (covS); SMu1047 (covS); SMu1048 (covR); SMu1378 (covS) and SMu1379 (covR).This sequence was previously published as gi14600273, a predicted CovX protein, in Genbank.","gtfB/C regulator, metallo-beta-lactamase superfamily","Cytoplasm","Few matches in gapped BLAST to vicX protein:residues 1-267 are 77% similar to vicX protein in S.pneumoniae (gi15901087).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0721 (1e-123).","

InterPro
IPR001279
Domain

Beta-lactamase-like
PF00753	$\"[16-196]T$	Lactamase_B

noIPR
unintegrated

unintegrated
G3DSA:3.60.15.10	$\"[1-255]T$	G3DSA:3.60.15.10
PTHR11203	$\"[28-82]T$	PTHR11203
PTHR11203:SF5	$\"[28-82]T$	PTHR11203:SF5
SSF56281	$\"[6-198]T$	SSF56281

","BeTs to 4 clades of COG1235COG name: Metal-dependent hydrolases of the beta-lactamase superfamily IFunctional Class: RThe phylogenetic pattern of COG1235 is amtK-q-CeB------o-INxNumber of proteins in this genome belonging to this COG is 1","***** IPB001587 (Uncharacterized protein family UPF0036) with a combined E-value of 1.3e-06. IPB001587B 37-85","Residues 29-84 are 76% similar to a (COMPLETE PROTEOME HYDROLASE FACTOR POLYADENYLATION) protein domain (PD000482) which is seen in Q9RCS5_STRPN.Residues 101-232 are 83% similar to a (PROTEOME COMPLETE HYDROLASE METAL) protein domain (PD261490) which is seen in Q9RCS5_STRPN.Residues 11-84 are 37% similar to a (PROTEOME COMPLETE BETA-LACTAMASE-LIKE) protein domain (PD293028) which is seen in Q9P9A7_AAAAA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 12:49:31 2006","Fri Sep 8 12:49:31 2006","Tue Feb 1 11:56:47 2005","Wed Mar 13 13:54:33 2002","Mon Jan 14 16:21:20 2002","Mon Jan 14 16:21:20 2002","yes","Mon Oct 21 07:11:38 2002","SMu1377 is paralogously related (blast p-value < 1e-3) to SMu0333 SMu0274 and SMu1208, all predicted conserved hypothetical proteins.","Wed Mar 13 13:58:04 2002","","No significant hits to the NCBI PDB database.","SMU.1515c","","Residues 16 to 196 (E-value = 6.7e-18) place SMu1377 in the Lactamase_B family which is described as Metallo-beta-lactamase superfamily (PF00753)","Mon Jan 14 16:21:20 2002","",""," Senadheera MD, Lee AW, Hung DC, Spatafora GA, Goodman SD, Cvitkovitch DG.The Streptococcus mutans vicX gene product modulates gtfB/C Expression, Biofilm Formation, Genetic Competence and Oxidative Stress Tolerance. Bacteriol. 2006 Nov 17;PMID: 17114248Lee SF, Delaney GD, Elkhateeb M.A two-component covRS regulatory system regulates expression of fructosyltransferase and a novel extracellular carbohydrate in Streptococcus mutans.Infect Immun. 2004 Jul;72(7):3968-73.PMID: 15213141","","Fri Sep 8 12:49:31 2006","","1","","","SMU.1515c","310" "SMu1378","1446208","1444856","1353","ATGACTAATGTGTTTGAATCAAGTCCCTTATTTTTACGAATTTTATTAGCAGTTTTAATCATTTTACTCTTTTTTTATTTTATTTTTCTCAATTACAGAGAGTATAAAAATAATAATCAAGTTAAACAGTTAAATGCTAAAGTACGTTCTTTGATTACTGGCCATTATACTGATAAATTAAAGGTTGAGGATAACTCTGACTTGTCAGAACTAGTGAATAACGTTAATGATTTATCAGAAGTTTTCCGTTTAACGCATGAAAATTTGGCACAGGAGAAAAACCGTCTGACTAGTATTTTATCTTATATGACAGATGGTGTTTTGGCAACAGATCGCAGCGGAAAGATTACCGTTATTAATGATATGGCGCAAAAGCAACTGAATGTAACGCGTGAGCAGGCATTGGAGTGCAATATTCTGGATATTTTGGATGATGATAGTTATACTTACAATGATTTGATTACAAAAACGCCAGAAATTGTTCTGACGCGGCGTGATGAATATGATGAATTTATCACTTTACGCATTCGTTTTGCCTTAAACCGCCGTGAAAGTGGCTTTATTTCAGGACTAATTGCTGTCTTGCATGATGCGACCGAACAGGAAAAAGAAGAACGTGAACGCCGTCTCTTTGTTTCTAATGTCAGTCATGAACTGCGGACACCATTAACCTCTGTAAAGTCCTATTTAGAAGCTTTGGACGATGGTGCCCTGACAGAATCAGTGGCTCCTAGCTTTATCAAGGTATCACTTGATGAGACTAATCGCATGATGCGTATGATTACTGATTTACTTAGCTTATCACGTATTGATAATCAGACCAGTCATCTAGATGTTGAATTGACGAATTTTACAGCTTTTATGAATTATATTCTGGATCGCTTTGATCAAATTCAAAGTCAGCAATCAACTAATAAGGTTTACGAAATTATTAGAGATTATCCTGACAAATCAGTTTGGATTGAAATTGATACCGATAAAATGACTCAGGTAATTGATAATATTTTAAATAATGCAATCAAATATTCACCTGATGGCGGTAAGGTGACTATAACGATGCAGACAACAGATACACAACTCATCCTTTCTATATCCGACCAAGGCTTGGGTATTCCTAAGAAGGATCTCCCTCTTATTTTTGACCGTTTTTATCGTGTTGATAAGGCAAGAAGCCGTGCTCAAGGTGGGACTGGTTTAGGATTAGCAATCGCCAAAGAAATTGTCAAACAGCATAAAGGCTTTATTTGGGCCAATAGTGAGGAAGGCGAAGGGTCGACCTTTACCATCGTTTTACCTTATGAAAACGATAATGATGCAATTGATGAATGGGAAGAAGATGAAGACGAATCATGA","4.50","-23.54","51686","MTNVFESSPLFLRILLAVLIILLFFYFIFLNYREYKNNNQVKQLNAKVRSLITGHYTDKLKVEDNSDLSELVNNVNDLSEVFRLTHENLAQEKNRLTSILSYMTDGVLATDRSGKITVINDMAQKQLNVTREQALECNILDILDDDSYTYNDLITKTPEIVLTRRDEYDEFITLRIRFALNRRESGFISGLIAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALTESVAPSFIKVSLDETNRMMRMITDLLSLSRIDNQTSHLDVELTNFTAFMNYILDRFDQIQSQQSTNKVYEIIRDYPDKSVWIEIDTDKMTQVIDNILNNAIKYSPDGGKVTITMQTTDTQLILSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIVKQHKGFIWANSEEGEGSTFTIVLPYENDNDAIDEWEEDEDES","1444871","For other 'cov' genes see SMu1377 (covX); SMu1031 (covS); SMu1047 (covS); SMu1048 (covR) and SMu1379 (covR).","two-component sensor histidine kinase","Membrane, Cytoplasm","Matches in gapped BLAST to a previously published sequence from S.mutans:residues 1-433 are 94% similar to sensor protein CovS (gi14600272).Residues 33-433 are 73% similar to the protein in S.pyogenes (gi15674629) and are 70% similar to the protein in S.pneumoniae (gi15903149). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0720 (1e-176).","

InterPro
IPR000014
Domain

PAS
SM00091	$\"[94-159]T$	PAS
TIGR00229	$\"[90-208]T$	sensory_box
PS50112	$\"[92-147]T$	PAS

InterPro
IPR001610
Repeat

PAC motif
SM00086	$\"[157-201]T$	PAC

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[278-434]T$	ATP_bd_ATPase
PF02518	$\"[323-434]T$	HATPase_c
SM00387	$\"[323-435]T$	HATPase_c
SSF55874	$\"[262-433]T$	ATP_bd_ATPase

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[207-273]T$	HisKA
SM00388	$\"[207-273]T$	HisKA

InterPro
IPR004358
Domain

Histidine kinase related protein, C-terminal
PR00344	$\"[360-374]T$ $\"[378-388]T$ $\"[395-413]T$ $\"[419-432]T$	BCTRLSENSOR

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[214-435]T$	HIS_KIN

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[197-269]T$	His_kin_homodim

InterPro
IPR013767
Domain

PAS fold
PF00989	$\"[94-198]T$	PAS

noIPR
unintegrated

unintegrated
G3DSA:3.30.450.20	$\"[94-209]T$	G3DSA:3.30.450.20
PTHR23283	$\"[87-445]T$	PTHR23283
PTHR23283:SF34	$\"[87-445]T$	PTHR23283:SF34
SSF55785	$\"[105-211]T$	SSF55785

","BeTs to 13 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","***** PR00344 (Bacterial sensor protein C-terminal signature) with a combined E-value of 1.5e-23. PR00344A 360-374 PR00344B 378-388 PR00344C 395-413 PR00344D 419-432***** IPB003661 (His Kinase A domain) with a combined E-value of 2.1e-11. IPB003661A 215-224 IPB003661B 334-343 IPB003661C 364-372***** IPB003660 (HAMP domain) with a combined E-value of 1.9e-06. IPB003660B 328-339 IPB003660C 390-405","Residues 88-135 are 45% similar to a (KINASE PROTEOME COMPLETE SENSORY) protein domain (PD000086) which is seen in Q9XCM6_STAAU.Residues 324-385 are 39% similar to a (TRANSFERASE PHOSPHORYLATION RPRX KINASE) protein domain (PD126133) which is seen in Q08408_BACFR.Residues 201-270 are 91% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD150714) which is seen in Q9S1J9_STRPN.Residues 270-327 are 31% similar to a (KINASE TRANSFERASE PHOSPHORYLATION) protein domain (PD200369) which is seen in Q9ZI94_LACSK.Residues 334-385 are 43% similar to a (PROTEOME TRANSFERASE PHOSPHORYLATION) protein domain (PD383244) which is seen in O53895_MYCTU.Residues 181-384 are 22% similar to a (REGULATION LUXN TRANSFERASE TRANSCRIPTION) protein domain (PD144852) which is seen in LUXN_VIBHA.Residues 201-432 are 23% similar to a (KINASE PROTEOME COMPLETE SENSOR) protein domain (PD360593) which is seen in Q9KM24_VIBCH.Residues 88-433 are 20% similar to a (YOJN TRANSFERASE PHOSPHORYLATION) protein domain (PD111987) which is seen in O85661_PROMI.Residues 328-384 are 80% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD371767) which is seen in Q9S1J9_STRPN.Residues 270-327 are 37% similar to a (KINASE PROTEOME TRANSFERASE) protein domain (PD088744) which is seen in O07384_LACLC.Residues 324-432 are 31% similar to a (KINASE TRANSDUCTION TRANSFERASE SENSORY) protein domain (PD036888) which is seen in Q9K620_BACHD.Residues 309-432 are 31% similar to a (KINASE SENSOR COMPLETE PROTEOME SENSORY TRANSDUCTION) protein domain (PD005700) which is seen in Q49120_METEX.Residues 146-200 are 41% similar to a (KINASE TRANSDUCTION TRANSFERASE) protein domain (PD404114) which is seen in Q9ZI94_LACSK.Residues 211-411 are 21% similar to a (KINASE PROTEOME COMPLETE TRANSFERASE) protein domain (PD113037) which is seen in Q9PN71_CAMJE.Residues 146-199 are 59% similar to a (KINASE TRANSFERASE PHOSPHORYLATION) protein domain (PD404052) which is seen in Q9S1J9_STRPN.Residues 334-413 are 35% similar to a (TRANSDUCTION TRANSFERASE PHOSPHORYLATION) protein domain (PD404615) which is seen in SPAK_BACSU.Residues 321-384 are 34% similar to a (KINASE SENSORY TRANSFERASE TRANSDUCTION) protein domain (PD406631) which is seen in Q9ZI92_LACSK.Residues 297-384 are 31% similar to a (TRANSFERASE PHOSPHORYLATION KINASE) protein domain (PD251328) which is seen in Q9KJN3_STAAU.Residues 316-384 are 32% similar to a (TRANSFERASE PHOSPHORYLATION KINASE) protein domain (PD395250) which is seen in O65995_CLOAB.Residues 200-432 are 21% similar to a (PROTEOME TRANSFERASE PHOSPHORYLATION) protein domain (PD132848) which is seen in Q55885_SYNY3.Residues 321-384 are 42% similar to a (KINASE TRANSDUCTION SENSORY COMPLETE) protein domain (PD396029) which is seen in Q55586_SYNY3.Residues 76-143 are 63% similar to a (KINASE TRANSDUCTION TRANSFERASE) protein domain (PD167976) which is seen in Q9S1J9_STRPN.Residues 271-327 are 63% similar to a (KINASE TRANSFERASE PHOSPHORYLATION) protein domain (PD259986) which is seen in Q9S1J9_STRPN.Residues 200-292 are 39% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD000142) which is seen in Q9K851_BACHD.Residues 385-431 are 87% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD000064) which is seen in Q9S1J9_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 13 13:15:03 2007","Thu May 2 12:07:04 2002","Tue Feb 1 11:58:01 2005","Wed Mar 13 14:08:23 2002","Tue Jan 8 11:57:28 2002","Tue Jan 8 11:57:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1378 is paralogously related (blast p-value < 1e-3) to SMu1031, SMu0842, SMu0602, SMu1652, SMu1047, SMu0919, and SMu0946, all predicted histidine kinases.","Wed Mar 13 14:08:23 2002","","No significant hits to the NCBI PDB database.","SMU.1516c","","Residues 94 to 155 (E-value = 1.9e-06) place SMu1378 in the PAS family which is described as PAS domain (PF00989)Residues 207 to 273 (E-value = 1.7e-21) place SMu1378 in the HisKA family which is described as His Kinase A (phosphoacceptor) domain (PF00512)Residues 323 to 434 (E-value = 3.6e-45) place SMu1378 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Tue Feb 1 11:58:01 2005","","","Lee SF, Delaney GD, Elkhateeb M.A two-component covRS regulatory system regulates expression of fructosyltransferase and a novel extracellular carbohydrate in Streptococcus mutans.Infect Immun. 2004 Jul;72(7):3968-73.PMID: 15213141","","Thu Jul 27 11:26:36 2006","","1","","","SMU.1516c","74" "SMu1379","1446908","1446201","708","ATGAAGAAAATTCTAATCGTTGACGATGAAAAACCAATTTCTGATATCATCAAGTTTAACTTGGCTAAGGAAGGTTATGACACGATTACAGCCTTTGATGGGCGTGAAGCATTAAGTAAATATGAAGAAGAAAATCCTGACTTGATTATATTGGACTTAATGTTACCAGAACTAGACGGTCTTGAAGTGGCTAAGGAAGTTAGAAAAAACAGCCATGTTCCAATTATTATGTTATCAGCTAAAGACAGTGAGTTTGATAAGGTTATTGGTCTTGAAATTGGTGCTGATGATTATGTGACTAAACCTTTTTCTAATCGTGAATTACTGGCGCGTGTAAAAGCGCATCTTCGCCGTACTGAAAATATTGAATCCGCAGTGGCTGAGGAAAATGCTTCAGGTATACCTGAAATTATTATTGGGGACTTGCAAATCTTACCAGATGCTTTTGTTGCTAAAAAACGTGGAACAGAGGTAGAGTTAACTCACCGTGAGTTTGAGTTGTTGCATCACTTAGCGACACACACAGGTCAGGTGATGACGCGTGAACATTTACTTGAAACGGTTTGGGGCTATGATTATTTTGGAGATGTCCGTACTGTTGATGTTACTGTTCGTCGTCTGCGTGAAAAAATTGAAGATACACCTAGTCGTCCAGAGTACATTTTGACGCGACGCGGTGTTGGTTATTACATGAAATCATATGACTAA","4.90","-11.29","26900","MKKILIVDDEKPISDIIKFNLAKEGYDTITAFDGREALSKYEEENPDLIILDLMLPELDGLEVAKEVRKNSHVPIIMLSAKDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIESAVAEENASGIPEIIIGDLQILPDAFVAKKRGTEVELTHREFELLHHLATHTGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD","1446216","For other 'cov' genes see SMu1377 (covX); SMu1031 (covS); SMu1047 (covS); SMu1048 (covR) and SMu1378 (covS).","two-component response regulator","Cytoplasm","Several matches in gapped BLAST to response regulator.Residues 1-235 are 94% similar to a previously published sequence from S.mutans (gi14600271). Residues 1-235 are 84% similar to gi15674628 from S.pyogenes and are 72% similar to gi15903150 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0719 (1e-110).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[3-117]T$	Response_reg
PF00072	$\"[2-113]T$	Response_reg
SM00448	$\"[2-112]T$	REC
PS50110	$\"[3-116]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[140-232]T$	Trans_reg_C
PF00486	$\"[155-231]T$	Trans_reg_C

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-197]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[3-138]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[2-121]T$	PTHR23283
PTHR23283:SF21	$\"[2-121]T$	PTHR23283:SF21

","BeTs to 8 clades of COG0745COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG0745 is -----QVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 10","***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 2.8e-66. IPB001867A 47-60 IPB001867B 74-118 IPB001867C 158-189 IPB001867D 217-231***** IPB001789 (Response regulator receiver domain) with a combined E-value of 6.2e-17. IPB001789A 4-10 IPB001789B 47-60 IPB001789C 94-103***** IPB000673 (CheB methylesterase) with a combined E-value of 1.3e-09. IPB000673B 19-72 IPB000673C 72-102","Residues 137-232 are 73% similar to a (DNA-BINDING TRANSDUCTION SENSORY TRANSCRIPTION) protein domain (PD000329) which is seen in Q9S1K0_STRPN.Residues 3-117 are 81% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in Q9S1K0_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 12:41:37 2006","Fri Sep 8 12:41:37 2006","Tue Feb 1 11:55:26 2005","Wed Mar 13 14:13:37 2002","Tue Jan 8 11:58:15 2002","Tue Jan 8 11:58:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1379 is paralogously related (blast p-value < 1e-3) to SMu1748, SMu1048, SMu1653, SMu1032, SMu0947, SMu0601, SMu0918, SMu0841, SMu1782, SMu0441, SMu0525, and SMu1406, all predicted response regulators.","Wed Mar 13 14:15:18 2002","Tue Feb 1 11:55:26 2005","pdb1B00A Chain A, Phob Receiver Domain From Escherichia Coli ... 110 2e-025pdb1TMY Chey From Thermotoga Maritima (Apo-I) >gi2781153p... 75 1e-014pdb1SRRA Chain A, Crystal Structure Of A Phosphatase Resistan... 73 4e-014","SMU.1517c","","Residues 2 to 120 (E-value = 2.5e-43) place SMu1379 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 155 to 231 (E-value = 1.9e-24) place SMu1379 in the Trans_reg_C family which is described as Transcriptional regulatory protein, C terminal (PF00486)","Tue Feb 1 11:55:26 2005","",""," Shemesh M, Tam A, Feldman M, Steinberg D.,Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases.Carbohydr Res. 2006 Sep 4;341(12):2090-7. Epub 2006 Jun 9.PMID: 16764842Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.J Bacteriol. 2005 Jun;187(12):4064-76.PMID: 15937169Lee SF, Delaney GD, Elkhateeb M.A two-component covRS regulatory system regulates expression of fructosyltransferase and a novel extracellular carbohydrate in Streptococcus mutans.Infect Immun. 2004 Jul;72(7):3968-73.PMID: 15213141Sato Y, Yamamoto Y, Kizaki HConstruction of region-specific partial duplication mutants (merodiploid mutants) to identify the regulatory gene for theglucan-binding protein C gene in vivo in Streptococcus mutans.FEMS Microbiol Lett 2000 May 15;186(2):187-91PubMed: 10802169PMID: 10802169","","Fri Sep 8 12:41:37 2006","","1","","","SMU.1517c","309" "SMu1380","1447261","1448043","783","ATGGCACTCATTACCTTTAAAAATGTGGAAAAATACTATGGGGACTACCATGCACTTCGTAATATAAATCTAGAAATTGAAAAAGGACAGGTTGTTGTTTTACTTGGTCCTTCAGGATCTGGGAAGTCCACACTTATTCGCACAATGAATGCTCTGGAATCCATTGACTCTGGTGAACTCATTGTTAACGGTCATGAAGTTACCAATGCTTCAACTAAGGACCTAGTCACACTTCGAAAAGAAGTTGGTATGGTTTTCCAACATTTTAATCTCTACCCTCACAAAACAGTGCTAGAAAACGTGACATTAGCCCCAATTAAAGTTTTAGGAATGGATAAGAAAAAGGCCGATGCTATTGCTGAAAAATATCTCACTTATGTTAACATGTGGGATCGCAAAGATTCCTATCCGGGTATGCTATCTGGCGGACAAAAACAGCGTATCGCTATTGCACGCGGACTAGCTATGAATCCTAAGTTACTGCTTTTTGATGAGCCAACTTCTGCACTGGATCCTGAAACCATTGGGGATGTTTTAGCCGTTATGAAAAATTTAGCCTTAGAAGGCATGAACATGGTCGTCGTCACTCACGAAATGGGATTTGCACGTGAAGTTGCCGATCGTATCATTTTTATGGCTGATGGAGAAATTCTAGAAGATACAACTGATGTTGATGGCTTCTTTAAACATCCAAAAGATCCACGAGCTCAACAGTTCTTAAGCAAAATTATCAATCATACCAGTGAAAAAGTGAATATCAACCAAAAAGGAGAAAGCGAATGA","6.20","-3.30","28939","MALITFKNVEKYYGDYHALRNINLEIEKGQVVVLLGPSGSGKSTLIRTMNALESIDSGELIVNGHEVTNASTKDLVTLRKEVGMVFQHFNLYPHKTVLENVTLAPIKVLGMDKKKADAIAEKYLTYVNMWDRKDSYPGMLSGGQKQRIAIARGLAMNPKLLLFDEPTSALDPETIGDVLAVMKNLALEGMNMVVVTHEMGFAREVADRIIFMADGEILEDTTDVDGFFKHPKDPRAQQFLSKIINHTSEKVNINQKGESE","1448052","For other components see SMu1382 (MSD1); SMu1383 (MSD2) and SMu1381 (SBP1)For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0329 (glnA);SMu0741 (glnH);SMu1080 (glnP); SMu1509 (glnB);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP).","glutamine ABC transport, ATP-binding protein","Cytoplasm, Membrane","Matches in gapped BLAST to ABC transporter ATP-binding protein homolog. Residues 18-256 are 34% similar to a previously published sequence in S.mutans (gi15625431),(gi4098078). Residues 1-251 are 81% similar to the protein from S.pneumoniae (gi15900518).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0718 (1e-118).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[140-182]T$	ABC_transporter
PF00005	$\"[29-215]T$	ABC_tran
PS00211	$\"[140-154]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-239]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-216]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-249]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-256]T$	PTHR19222
PTHR19222:SF33	$\"[4-256]T$	PTHR19222:SF33
SSF52540	$\"[3-243]T$	SSF52540

","BeTs to 7 clades of COG1126COG name: ABC-type polar amino acid transport system, ATPase componentFunctional Class: EThe phylogenetic pattern of COG1126 is a-----vcEB-Huj----inxNumber of proteins in this genome belonging to this COG is 7","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2e-38. IPB001140A 18-64 IPB001140B 137-175 IPB001140C 192-221","Residues 183-222 are 70% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORT) protein domain (PD007174) which is seen in Q9JVC3_NEIMA.Residues 124-216 are 30% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 185-222 are 68% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9KGD1_BACHD.Residues 80-114 are 68% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496) which is seen in GLNQ_BACST.Residues 131-219 are 31% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q44375_AGRTU.Residues 73-113 are 58% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230) which is seen in Y4TH_RHISN.Residues 183-220 are 78% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in GLNQ_BACST.Residues 24-243 are 29% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in O27709_METTH.Residues 74-112 are 69% similar to a (ATP-BINDING TRANSPORT PROTEOME ABC) protein domain (PD412673) which is seen in Q9JVC3_NEIMA.Residues 185-240 are 51% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD255463) which is seen in Q9ZK44_HELPJ.Residues 140-174 are 77% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459) which is seen in MDR1_LEIEN.Residues 19-69 are 64% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9JVC3_NEIMA.Residues 140-182 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CES4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 8 12:33:49 2006","Wed Oct 23 14:59:08 2002","Fri Sep 8 12:33:49 2006","Wed Mar 13 14:21:36 2002","Wed Mar 13 14:21:36 2002","Wed Mar 13 14:21:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1380 is paralogously related (blast p-value < 1e-3) to SMu0517, SMu0731, SMu0849, SMu0418, SMu0218, SMu1079, SMu1762, SMu1920, SMu1210, SMu0971, SMu1036, SMu1068, SMu1246, SMu1231, SMu1003, SMu1288, SMu0884, SMu1751, SMu0786, SMu1037, SMu0916, SMu1023, SMu0235, SMu0594, SMu1949, SMu1950, SMu1428, SMu0805, SMu0234, SMu0216, SMu1001, SMu1517, SMu0335, SMu0596, SMu1757, SMu0390, SMu0825, SMu1518, SMu0950, SMu0907, SMu0374, SMu0476, SMu1649, SMu1093, SMu0944, SMu1316, SMu1710, SMu0986, SMu0475, SMu0666, SMu1064, SMu1410, SMu0258, SMu0024, SMu0837, SMu1811, SMu1724, SMu0824, SMu1065, SMu0976, SMu0164, SMu0224, SMu1306, SMu1545, SMu0752, SMu0729, SMu1050, SMu0836, SMu0987, SMu0823, SMu1959, SMu1202, and SMu1686, all with ATP binding capabilities.","Wed Apr 3 11:11:17 2002","Fri Sep 8 12:33:49 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 224 9e-060pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 125 7e-030","SMU.1519","","Residues 29 to 215 (E-value = 1.8e-68) place SMu1380 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Mar 13 14:21:36 2002","24379908","","","","Fri Sep 8 12:33:49 2006","","1","","","SMU.1519","308" "SMu1381","1448040","1448852","813","ATGAACATCAAAAAATTTCTCATCAGTTTGGCTGCTCTGATTATGATTGCAACAAGCCTTTCAGGATTATCCAAAGTAAACGCTGATAATGTAACCTCTCCACAAGTTAAAAAAATTAAAAGGGCTGGAGTGCTTAAGGTCGGTGTCAAGCAAGATGTTCCTAATTTCGGTTATTACAATGCTGAGACGGGTAAATACGAGGGAATGGAAATTGATATTGCTCGTAAAATCGCCAAATCTATTGGGGTAAAACTTGAACTTGTTCCCGTTACGACTCAAACTCGTGAACCTCTTATGGACAACGGCCAAGTTGACCTAGTTATTGCTACCTATACCATTACTCCAGAACGTCAAGCTTCTTACAGTATTTCTAAACCTTATTATTATGACCAAATTGGTTTTTTGGTTCGTCAATCAAGCAAGATCTCAAAAATTTCTGATCTAGACGGACTTACTATTGGTGTTTCTCAAGGGGCAACAACTAAGGTTAATCTTGAAGCTTATGCTAAAAAACACCACTTAAAATTTAACTATGTTCAATTGGGAAGTTTCCCTGAACTTGCTATTTCTCTCTATTCTAAACGCATTGACGCTTTTTCTGTTGATAAGTCCATCCTCACTGGCTATGTCAGCAAGCAATCTAAATTGCTAAAATCTGGCTTTAATACGCAAGAATATGGTATTGCCACCAAAAAATCAAATACTGGCTTAACAAAATATGTTAATTATTTATTAAAAAAATGGACTGCTGATAAAAGTCTTGAAAGCATTTATAATAAACATAATCTTGAATCAGCCAAACCAGATAAATAA","10.50","16.72","29940","MNIKKFLISLAALIMIATSLSGLSKVNADNVTSPQVKKIKRAGVLKVGVKQDVPNFGYYNAETGKYEGMEIDIARKIAKSIGVKLELVPVTTQTREPLMDNGQVDLVIATYTITPERQASYSISKPYYYDQIGFLVRQSSKISKISDLDGLTIGVSQGATTKVNLEAYAKKHHLKFNYVQLGSFPELAISLYSKRIDAFSVDKSILTGYVSKQSKLLKSGFNTQEYGIATKKSNTGLTKYVNYLLKKWTADKSLESIYNKHNLESAKPDK","1448861","For other components see SMu1380 (NBD1); SMu1382 (MSD1) and SMu1383 (MSD2).For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0329 (glnA);SMu0741 (glnH);SMu1080 (glnP); SMu1509 (glnB);SMu1380 (glnQ); SMu1382 (glnM) and SMu1383 (glnP).","amino acid ABC transporter, substrate-binding protein","Extracellular, Membrane","Matches in gapped BLAST to ABC transporter ATP-binding protein homolog. Residues 64-270 are 24% similar to a previously published sequence in S.mutans (gi15625428). Residues 4-264 are 50% similar to the protein from S.pneumoniae (gi15902578).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0717 (3e-93).","

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[45-264]T$	SBP_bac_3
SM00062	$\"[44-265]T$	PBPb

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[42-172]T$	G3DSA:3.40.190.10
SSF53850	$\"[1-269]T$	SSF53850

","BeTs to 9 clades of COG0834COG name: Periplasmic amino acid binding proteinsFunctional Class: EThe phylogenetic pattern of COG0834 is A-----VCEBrHUJ---LINxNumber of proteins in this genome belonging to this COG is 8","***** IPB001638 (Bacterial extracellular solute-binding proteins, family 3) with a combined E-value of 1.5e-10. IPB001638A 64-73 IPB001638B 96-127","Residues 169-247 are 43% similar to a (FACTOR ANTIGEN PRECURSOR MAJOR) protein domain (PD272323) which is seen in PEB1_CAMJE.Residues 43-161 are 50% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT ABC TRANSPORTER) protein domain (PD245531) which is seen in PEB1_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 15:24:35 2006","Tue Aug 29 15:24:35 2006","Tue Aug 29 15:17:05 2006","Wed Mar 13 14:25:42 2002","Wed Mar 13 14:25:42 2002","Wed Mar 13 14:25:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1381 is paralogously related (blast p-value < 1e-3) to SMu0741, SMu1078, SMu0739, SMu0732, SMu0219, SMu1112, and SMu1765, all predicted amino acid ABC transporter substrate binding proteins.","Wed Mar 13 14:29:22 2002","Tue Aug 29 15:17:05 2006","pdb1WDNA Chain A, Glutamine-Binding Protein >gi1943541pdb1... 71 2e-013","SMU.1520","","Residues 45 to 264 (E-value = 1.3e-62) place SMu1381 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)","Wed Mar 13 14:25:42 2002","24379909","","","","","","1","","","SMU.1520","540" "SMu1382","1448870","1449574","705","ATGCTACTATTTACTGCTACTTCCGGCCCTTTTGCTCTGAGCCGCTGGTCTGCATTTTTTGCCAATTTCAATCAATTTTTAAAAGGCTTCTTTTATACACTTGAAATGTCCGTCTTCGCTTTACTGCTTTCTTTAATTCTTGGTGTTATTTTTGGCGCCATGAGTTCCTCTAAAACTAAGCTTCTCAAAGGAATAGCCCGTGTTTATGTTGAGATTTTTCAAAATACACCATTATTGGTACAATTCGTCTTTGTTTATTACGGGTTAGCTATTATGACAAACGGTGCTGTTATGATCTCAGCCTTCTTTACTGCAGTACTTTGTGTTGGTATTTACCACGGTGCTTACATTGCAGAAGTCATTCGCTCTGGTATTGAAGCTGTGCCTAGAGGACAAACCGAAGCAGCTCTTTCTCAAGGATTTACCTATCAAGAGACCATGAGTCTAATTATCTTGCCGCAGGCCATCAGAACTATCTTGCCACCAATGACTAACCAAGTGGTTAACTTGATAAAAAATACATCAACAGTTGCTATTATTTCAGGTGCGGATATCATGTTTACGGCCAAAGCTTGGGCCTACGAAACAACTAATTACATCCCTGCTTTTGCTGGTGCCGCCTTCCTTTACTTCATCATGTGTTTCCCTCTTGCAACTTGGGCTCGACGTAAAGAAGAAGCTAACAAAGAAGCTTATCATTTATAA","9.70","4.37","25899","MLLFTATSGPFALSRWSAFFANFNQFLKGFFYTLEMSVFALLLSLILGVIFGAMSSSKTKLLKGIARVYVEIFQNTPLLVQFVFVYYGLAIMTNGAVMISAFFTAVLCVGIYHGAYIAEVIRSGIEAVPRGQTEAALSQGFTYQETMSLIILPQAIRTILPPMTNQVVNLIKNTSTVAIISGADIMFTAKAWAYETTNYIPAFAGAAFLYFIMCFPLATWARRKEEANKEAYHL","1449583","For other components see SMu1380 (NBD1); SMu1383 (MSD2) and SMu1381 (SBP1).For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0329 (glnA);SMu0741 (glnH);SMu1080 (glnP); SMu1509 (glnB);SMu1380 (glnQ); SMu1381 (glnH) and SMu1383 (glnP).","amino acid (glutamine) ABC transporter permease","Membrane, Cytoplasm","Several matches in gapped BLAST to ABC transporter (permease protein):residues 13-234 are 62% similar to the protein in S.pyogenes (gi15900516).Residues 10-232 are 50% similar to the protein from Campylobacter jejuni (gi15792249). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0716 (1e-99).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[30-230]T$	BPD_transp_1
PS50928	$\"[30-221]T$	ABC_TM1

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[22-123]T$	HEQRo_perm_3TM

","BeTs to 7 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 33-92 are 45% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC COMPLETE) protein domain (PD001196) which is seen in Q9PP13_CAMJE.Residues 159-217 are 59% similar to a (TRANSPORT PERMEASE ABC TRANSPORTER) protein domain (PD006016) which is seen in Q9PP13_CAMJE.Residues 97-154 are 60% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in Q9PP13_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 15:15:25 2006","Tue Aug 29 15:15:25 2006","Tue Aug 29 15:13:37 2006","Wed Mar 13 14:33:35 2002","","Wed Mar 13 14:33:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1382 is paralogously related (blast p-value < 1e-3) to SMu0219, SMu0732, SMu1080, SMu1111, SMu1383, SMu0516, SMu0848, SMu0417, SMu0847, SMu1923, SMu1426, and SMu1038, all predicted ABC transporters.","Wed Mar 13 14:36:20 2002","","No significant hits to the NCBI PDB database.","SMU.1521","","Residues 30 to 230 (E-value = 2.8e-22) place SMu1382 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Mar 13 14:33:35 2002","24379910","","","","","","1","","","SMU.1521","539" "SMu1383","1449589","1450239","651","ATGAAAGCATTATTAACACCCACAAATCTCAATTTTTTACTTCAAGGTTTGTGGCTAACACTTTATATCTCTTTTATTTCCATTGTACTATCTACCATTTTGGGAACGATTCTAGCTGTTATGCGCAATGGTAAAAATAAACCGCTAAGATGGATTGCTAGTATTTATATTGAGTTCGTCAGAAATGTTCCTAATCTTTTATGGATTTTCATTGTCTTTCTTGTCTTTCAAATGAAATCCACTCCTGCTGGTATTACTGCTTTCACTGTTTTTACCTCTGCAGCTCTAGCAGAAATTATCCGAGGCGGATTAAATGCTATTGATAATGGACAAACTGAGGCAGGACTTGCTCAAGGATTAACCAATTCTCAGATTTTTATTTATATCATTTTCCCTCAGGCTATCAGAAAAATGCTGCCAGCTATCATTTCCCAATTTGTAACTGTTATTAAAGATACTTCTTTTCTTTATTCTGTTATTGCCCTTCAAGAATTATTCGGAAAAAGTCAAATTTTGATGGGAAAATATTTTGAAGCTGATCAAGTCTTTGCTCTTTATGGGATTGTTGCAGTAACTTATTTTATCATTAACTTTATCATTTCAAGTTTTTCTCGCCGTCTTGCTAAAAAGTGGGAACAAGCAACGGACTAA","10.60","6.99","24222","MKALLTPTNLNFLLQGLWLTLYISFISIVLSTILGTILAVMRNGKNKPLRWIASIYIEFVRNVPNLLWIFIVFLVFQMKSTPAGITAFTVFTSAALAEIIRGGLNAIDNGQTEAGLAQGLTNSQIFIYIIFPQAIRKMLPAIISQFVTVIKDTSFLYSVIALQELFGKSQILMGKYFEADQVFALYGIVAVTYFIINFIISSFSRRLAKKWEQATD","1450248","For other components see SMu1380 (NBD1); SMu1382 (MSD1) and SMu1381 (SBP1).For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0329 (glnA);SMu0741 (glnH);SMu1080 (glnP); SMu1509 (glnB);SMu1380 (glnQ); SMu1381 (glnH) and SMu1382 (glnM).","amino acid (glutamine) ABC transporter permease","Membrane, Cytoplasm","Several matches in gapped BLAST to ABC transporter membrane- spanning permease: residues 4-216 are 71% similar to the enzyme in S.pneumoniae (gi15902576) and residues 9-207 are 40% similar to the enzyme in B.subtilis (gi16079799).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0715 (4e-84).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[13-209]T$	BPD_transp_1
PS50928	$\"[17-204]T$	ABC_TM1

InterPro
IPR010065
Domain

Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726	$\"[9-102]T$	HEQRo_perm_3TM

","BeTs to 8 clades of COG0765COG name: Amino acid ABC transporter permease componentFunctional Class: EThe phylogenetic pattern of COG0765 is a-----vcEB-HUJ----inxNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 13-73 are 44% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC COMPLETE) protein domain (PD001196) which is seen in Q9RVK0_DEIRA.Residues 83-134 are 53% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE ABC TRANSPORTER) protein domain (PD267580) which is seen in O34606_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 14:08:21 2006","Tue Aug 29 14:08:21 2006","Tue Aug 29 14:08:21 2006","Wed Mar 13 14:42:16 2002","","Wed Mar 13 14:42:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1383 is paralogously related (blast p-value < 1e-3) to SMu0732, SMu0219, SMu1382, SMu1080, SMu1111, SMu0516, SMu0848, SMu0417, SMu0847, SMu1038, SMu1426, and SMu0970 , all predicted amino acid ABC transporters, amino acid substrate-binding proteins.","Wed Mar 13 14:42:16 2002","","No significant hits to the NCBI PDB database.","SMU.1522","","Residues 13 to 209 (E-value = 3e-27) place SMu1383 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Mar 13 14:42:16 2002","24379911","","","","","","1","","","SMU.1522","538" "SMu1384","1451188","1450307","882","ATGACTAGAAAAACGAACAAGTCTCAGCGAAAACAGCAAAAATTATGCTTATCTCTCCTTGCTGCTTTGAGCGTATTTGTTTGTACTTATATTGCAACCAGTGATCATATTGCTGATAGTAACCCTATAAAGCAGGCTGCCCAATTATTGACAGGTAAAAACAAGGATATACTTTCAAATGGTTCAATGAGCCATCAAGCGACTCCCAGTCAAGAATTAGCCAATACTGTTATGACGGATGCAGTAAAAAATGCCTTGGGTAGACAAATTGAATGGAGTGGTGCAGGTTCTTTCATTATTAATCATAATAAAACTGACCTTAACGCTGATGTTGCTAGCCAACCGTATGCTAGTAATCAGACCAAAATCGTTCAAGGACAGACAGTACCAACAGTAGCAAATGCTTTGTTAAGTAAGGCTACTCGTCAGTACCGAAACCGCCAAGAGACAGGAAATGGCAGGACAAATTGGCAGCCAGCAGGCTGGCATCAGCTTTATGATTTGCCGGGTGACTATGATCACGCGGTTGATCGTGGACACTTATTGGCTTATGCTTTGGTTGGTGGTTTGAAACGATTTGATGCTTCAACGAGTAATCCTCAAAATGTAGCAACACAAGCAGCTTGGGCTAATGAAGCCAATAGTTCAAACTCAAGGGGACAAAATTATTATGAAACACTGATTAGAAAAGCTTTGGATAGTCATAAGCGTGTTCGTTATCGTGTGACTCTTATCTATGATGACAACAATGATATCTTAGCCAGTGGCAGTCATCTAGAAGCCAAATCATCAGATGGCAGTCTAGAGTTCAATGTCTTTATTCCTAATGTTCAAAGCGGTTTGACCTTTGATTATGCAACAGGACAAGTTAAGGCAAATTAA","10.00","7.82","32117","MTRKTNKSQRKQQKLCLSLLAALSVFVCTYIATSDHIADSNPIKQAAQLLTGKNKDILSNGSMSHQATPSQELANTVMTDAVKNALGRQIEWSGAGSFIINHNKTDLNADVASQPYASNQTKIVQGQTVPTVANALLSKATRQYRNRQETGNGRTNWQPAGWHQLYDLPGDYDHAVDRGHLLAYALVGGLKRFDASTSNPQNVATQAAWANEANSSNSRGQNYYETLIRKALDSHKRVRYRVTLIYDDNNDILASGSHLEAKSSDGSLEFNVFIPNVQSGLTFDYATGQVKAN","1450322","For other 'end' genes see SMu1502 (end3).","competence associated membrane nuclease (DNA-entry nuclease)","Extracellular","Few matches in gapped BLAST to DNA-entry nuclease: residues 59-290 are 61% similar to the enzyme from S.pneumoniae (gi15901787) and residues 159-293 are 68% similar to the enzyme from S.pyogenes (gi15674813).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0868 (2e-90).","

InterPro
IPR001604
Family

DNA/RNA non-specific endonuclease
PF01223	$\"[112-292]T$	Endonuclease_NS
PS01070	$\"[177-185]?$	NUCLEASE_NON_SPEC

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 59-290 are 61% similar to a (NUCLEASE COMPETENCE-SPECIFIC DNA-ENTRY) protein domain (PD125019) which is seen in NUCE_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 17:23:05 2006","Tue Aug 29 17:23:05 2006","Tue Aug 29 17:23:05 2006","Wed Mar 13 14:44:37 2002","","Wed Mar 13 14:44:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1384 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 13 14:48:13 2002","","No significant hits to the NCBI PDB database.","SMU.1523c","","Residues 60 to 279 (E-value = 6.3e-09) place SMu1384 in the Endonuclease_NS family which is described as DNA/RNA non-specific endonuclease (PF01223)","Wed Mar 13 14:44:37 2002","","","","Puyet,A., Greenberg,B. and Lacks,S.A.Genetic and structural characterization of endA. A membrane-boundnuclease required for transformation of Streptococcus pneumoniaeJ. Mol. Biol. 213 (4), 727-738 (1990)PubMed: 2359120","","Wed Mar 13 14:48:13 2002","1","","","SMU.1523c","549" "SMu1385","1451418","1451230","189","ATGAATAGTGGTTGGAAATATGTTCGGAATCAATTAGCTTTTGTTGTCCTCATTGCTCTTTTATGTCTCATTTTTCTGGCAATCGGTCTAATGATTGGTTATAGTTTTATTGGTGAAGGTAGAAATCCTTTATCTATCTTATTCTGGGATAAATGGCAGTCAATCATTGATAAATTTACTGGAAAGTAG","10.20","2.93","7093","MNSGWKYVRNQLAFVVLIALLCLIFLAIGLMIGYSFIGEGRNPLSILFWDKWQSIIDKFTGK","1451245","","conserved hypothetical protein","Membrane, Extracellular","Only matches in gapped BLAST to conserved competence associated hypothetical protein: residues 1-62 are 40% similar to gi|15674812| from S.pyogenesThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0867 (2e-09).","

noIPR
unintegrated

unintegrated
PD053619	$\"[1-62]T$	PD053619

InterPro
IPR001986
Domain

3-phosphoshikimate 1-carboxyvinyltransferase
PD001867	$\"[11-415]T$	Q8DT57_STRMU_Q8DT57;
G3DSA:3.65.10.10	$\"[22-232]T$ $\"[235-371]T$	no description
PF00275	$\"[6-410]T$	EPSP_synthase

InterPro
IPR005750
Family

UDP-N-acetylglucosamine 1-carboxyvinyltransferase
PTHR21090:SF4	$\"[76-420]T$	UDP-N-ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE
TIGR01072	$\"[1-419]T$	murA: UDP-N-acetylglucosamine 1-carboxyviny

noIPR
unintegrated

unintegrated
PTHR21090	$\"[76-420]T$	AROM/DEHYDROQUINATE SYNTHASE

","BeTs to 11 clades of COG0766COG name: UDP-N-acetylglucosamine enolpyruvyl transferaseFunctional Class: MThe phylogenetic pattern of COG0766 is -----qvceBrhuj--olinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 262-335 are 40% similar to a (TRANSFERASE UDP-N-ACETYLGLUCOSAMINE CELL) protein domain (PD413614) which is seen in Q9KKF2_LISMO.Residues 391-423 are 69% similar to a (TRANSFERASE UDP-N-ACETYLGLUCOSAMINE CELL) protein domain (PD166002) which is seen in MUA2_LACLA.Residues 336-389 are 68% similar to a (TRANSFERASE UDP-N-ACETYLGLUCOSAMINE CELL) protein domain (PD332044) which is seen in MUA2_LACLA.Residues 13-389 are 56% similar to a (TRANSFERASE SYNTHASE 1-CARBOXYVINYLTRANSFERASE) protein domain (PD001867) which is seen in Q9K6I0_BACHD.Residues 1-123 are 57% similar to a (TRANSFERASE UDP-N-ACETYLGLUCOSAMINE CELL) protein domain (PD404695) which is seen in MUA2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Nov 5 13:46:59 2002","Wed Mar 13 15:11:24 2002","Thu Oct 17 15:20:31 2002","Wed Mar 13 15:11:24 2002","","Wed Mar 13 15:11:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1386 is paralogously related (blast p-value < 1e-3) to SMu1429, a predicted UDP-N-acetylglucosamine 1-carboxyvinyltransferase.","Wed Mar 13 15:14:48 2002","Wed Mar 13 15:11:24 2002","pdb|1UAE| Structure Of Udp-N-Acetylglucosamine Enolpyruvyl Tr... 373 3e-104pdb|1NAW|A Chain A, Enolpyruvyl Transferase >gi|2392465|pdb|1NA... 372 3e-104pdb|1EYN|A Chain A, Structure Of Mura Liganded With The Extrins... 372 4e-104","SMU.1525c","","Residues 9 to 410 (E-value = 9e-136) place SMu1386 in the EPSP_synthase family which is described as EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (PF00275)","Wed Mar 13 15:11:24 2002","","","","Marquardt,J.L., Siegele,D.A., Kolter,R. and Walsh,C.T.Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseJ. Bacteriol. 174 (17), 5748-5752 (1992)PubMed: 1512209Skarzynski,T., Mistry,A., Wonacott,A., Hutchinson,S.E., Kelly,V.A.and Duncan,K.Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, anenzyme essential for the synthesis of bacterial peptidoglycan,complexed with substrate UDP-N-acetylglucosamine and the drugfosfomycinStructure 4 (12), 1465-1474 (1996)PubMed: 8994972Griffiths E, Gupta RS.Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA betweenchlamydiae and Streptomyces.Microbiology. 2002 Aug;148(Pt 8):2541-9.PMID: 12177347","","Tue Nov 5 13:46:37 2002","1","","","SMU.1525c","97" "SMu1387","1452967","1452758","210","ATGTTGATGAGTCATTTTATATTCATTGCTATTTTTTACAATCTTCTGATTAATTTATTTGATTGGGGAAAAATTGTTAAACGAGCTTCTGAGAATATAGGACGTCTTAAATTGTTTTTGTTGTTTATTAGCATTGTCATTGGTTATATGGTTAGTACCTTTATCTGGTCTGTCATTTCGTTAAGTCAAGATATCTTTTTTGCGATTTAA","10.30","2.22","8063","MLMSHFIFIAIFYNLLINLFDWGKIVKRASENIGRLKLFLLFISIVIGYMVSTFIWSVISLSQDIFFAI","1452773","","conserved hypothetical protein","Membrane, Cytoplasm","Only matches in gapped BLAST to conserved hypothetical protein: residues 5-67 are 39% similar to gi15674810 from S.pyogenesThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0865 (2e-18).","

InterPro
IPR009526
Family

Conserved hypothetical protein, integral membrane YwzB
TIGR02327	$\"[1-69]T$	int_mem_ywzB

InterPro
IPR001469
Family

ATPase, F1 complex, delta/epsilon subunit
PD000944	$\"[20-87]T$	ATPsynt_DE
G3DSA:2.60.15.10	$\"[1-91]T$	ATPase_F1_d/e
PTHR13822	$\"[3-137]T$	ATPase_F1_d/e
PF00401	$\"[89-138]T$	ATP-synt_DE
PF02823	$\"[3-87]T$	ATP-synt_DE_N
TIGR01216	$\"[3-134]T$	ATP_synt_epsi
SSF46604	$\"[89-135]T$	ATPsynt_DE
SSF51344	$\"[2-88]T$	ATPsynt_DE

noIPR
unintegrated

unintegrated
PTHR13822:SF2	$\"[3-137]T$	PTHR13822:SF2

","BeTs to 9 clades of COG0355COG name: FoF1-type ATP synthase epsilon subunitFunctional Class: CThe phylogenetic pattern of COG0355 is ----yqvcebrhuj------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001469 (ATP synthase, Delta/Epsilon chain) with a combined E-value of 1.2e-25. IPB001469A 15-52 IPB001469B 66-86","Residues 84-134 are 64% similar to a (EPSILON SYNTHASE HYDROLASE ION) protein domain (PD006046) which is seen in ATPE_STRMU.Residues 8-83 are identical to a (SYNTHASE EPSILON CHAIN ION HYDROLASE CF1 SYNTHESIS) protein domain (PD000944) which is seen in ATPE_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 11:41:39 2006","Thu May 2 12:13:31 2002","Mon Sep 11 11:41:39 2006","Wed Mar 13 15:21:35 2002","Wed Mar 13 15:21:35 2002","Wed Mar 13 15:21:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1388 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 11 14:09:43 2002","","No significant hits to the NCBI PDB database.","SMU.1527c","","Residues 3 to 87 (E-value = 3.7e-29) place SMu1388 in the ATP-synt_DE_N family which is described as ATP synthase, Delta/Epsilon chain, beta-sandwich domain (PF02823)Residues 89 to 138 (E-value = 2e-07) place SMu1388 in the ATP-synt_DE family which is described as ATP synthase, Delta/Epsilon chain, long alpha-helix domain (PF00401)","Mon Sep 11 11:41:39 2006","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C.Cloning and nucleotide sequence analysis of the Streptococcusmutans membrane-bound, proton-translocating ATPase operonGene 183 (1-2), 87-96 (1996)PubMed: 8996091","","Wed Mar 13 15:21:35 2002","","1","","","SMU.1527c","791" "SMu1389","1455100","1453694","1407","ATGAGCACAGGCAAAATTGCTCAGGTAGTTGGTCCTGTTGTTGATGTTGCATTTGCGACAGATGATAAACTTCCTGAGATTAATAATGCATTGGTCGTTTATAAAGATGGCGACAAGTCTCAAAGAATTGTTCTTGAAGTTGCCCTTGAACTCGGTGATGGACTAGTTCGTACCATTGCTATGGAGTCAACTGATGGTTTAACACGTGGGCTTGAAGTCTTTGATACGGGCCGTGCTATCAGTGTTCCGGTTGGAAAAGAAACACTAGGTCGTGTCTTTAATGTTCTTGGAGATACGATTGACCTTGATAAGCCTTTTGCAGAAGATGCTGAACGTCAGCCAATTCATAAAAAGGCACCATCATTTGATGATCTATCAACTTCAACTGAGATTTTAGAAACAGGAATTAAAGTTATTGACCTTCTTGCCCCTTATCTTAAAGGTGGTAAAGTCGGCCTTTTTGGTGGTGCCGGTGTCGGAAAGACCGTTTTGATTCAGGAGTTAATTCATAATATTGCTCAAGAGCATGGCGGGATTTCGGTATTTACTGGTGTTGGTGAACGGACACGTGAAGGAAATGACCTTTATTGGGAAATGAAAGAATCTGGTGTTATTGAAAAGACAGCTATGGTCTTTGGTCAGATGAATGAACCGCCTGGAGCACGGATGCGTGTTGCTCTTACTGGTCTTACCATCGCTGAATACTTCCGTGATGTAGAAGGTCAGGATGTGCTTCTTTTCATTGATAACATTTTCCGTTTTACCCAAGCAGGTTCTGAAGTTTCAGCTCTTCTTGGCCGTATGCCATCAGCCGTTGGTTATCAGCCAACCTTGGCAACTGAAATGGGGCAATTGCAAGAACGGATTACATCGACGAAAAAAGGTTCTGTTACCTCAATTCAGGCCATCTATGTGCCAGCCGATGACTATACTGACCCTGCGCCAGCTACAGCCTTTGCTCACTTAGATTCAACCACTAACCTTGAACGCCGTCTGACACAAATGGGGATTTACCCAGCGGTGGATCCTTTAGCTTCAAGTTCACGTGCTCTCTCGCCTGAAATAGTTGGTCAAGAGCACTACGATGTTGCCACAGAAGTACAGCATGTCTTGCAGCGTTATCGTGAGTTACAAGATATTATAGCTATTCTTGGTATGGATGAGTTATCTGATGAAGAAAAGACTCTGGTTGGCCGTGCGCGTCGGATTCAGTTCTTCCTTTCACAAAATTTCAATGTTGCAGAACAATTTACAGGACAGCCGGGTTCTTATGTTCCTGTTGCTGAAACTGTCCGTGGATTTAAAGAAATTCTCGAAGGAAAATATGATGAACTTCCAGAAGATGCTTTCCGAAGTGTTGGAGCTATTGAGGATGTTGTTGAAAAAGCCAAGAATATGGGTGTTTAA","4.50","-23.50","50965","MSTGKIAQVVGPVVDVAFATDDKLPEINNALVVYKDGDKSQRIVLEVALELGDGLVRTIAMESTDGLTRGLEVFDTGRAISVPVGKETLGRVFNVLGDTIDLDKPFAEDAERQPIHKKAPSFDDLSTSTEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTKKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERRLTQMGIYPAVDPLASSSRALSPEIVGQEHYDVATEVQHVLQRYRELQDIIAILGMDELSDEEKTLVGRARRIQFFLSQNFNVAEQFTGQPGSYVPVAETVRGFKEILEGKYDELPEDAFRSVGAIEDVVEKAKNMGV","1453709","See SMu1388 for proton-translocating ATPase, epsilon subunit. See SMu1390 for ATPase, gamma subunit.See SMu1391 for ATP synthase alpha chain.See SMu1392 for ATPase, delta subunit.See SMu1394 for ATPase, a subunit.See SMu1393 for ATPase, b subunit.See SMu1395 for ATPase, c subunit.","ATPase beta subunit","Cytoplasm","Matches in gapped BLAST to ATP synthase beta subunit:residues 1- 468 are 92% similar to the previously published enzyme in S.mutans (gi6226557) and (gi4239652)Residues 1-467 are 86% similar to ATP synthase beta subunit in S.pyogenes (gi15674808). This sequence is similar to Spy0154, a proposed alpha subunit sequence. The truer ortholog is Spy0760. See also Sag0861.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0863 (0.0).","

InterPro
IPR000194
Domain

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding
PF00006	$\"[134-348]T$	ATP-synt_ab
PS00152	$\"[339-348]T$	ATPASE_ALPHA_BETA

InterPro
IPR000793
Domain

ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
PF00306	$\"[361-468]T$	ATP-synt_ab_C
SSF47917	$\"[351-468]T$	ATPase_a/b_C

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[147-332]T$	AAA

InterPro
IPR004100
Domain

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal
PF02874	$\"[6-77]T$	ATP-synt_ab_N
SSF50615	$\"[1-79]T$	ATPase_a/b_N

InterPro
IPR005722
Family

ATPase, F1 complex, beta subunit
PTHR15184:SF8	$\"[1-380]T$	ATPase_F1_b
TIGR01039	$\"[2-466]T$	atpD

noIPR
unintegrated

unintegrated
G3DSA:1.10.1140.10	$\"[351-466]T$	G3DSA:1.10.1140.10
G3DSA:2.40.10.170	$\"[1-79]T$	G3DSA:2.40.10.170
G3DSA:3.40.50.300	$\"[80-350]T$	G3DSA:3.40.50.300
PTHR15184	$\"[1-380]T$	PTHR15184
SSF52540	$\"[80-352]T$	SSF52540

","BeTs to 10 clades of COG0055COG name: FoF1-type ATP synthase beta subunitFunctional Class: CThe phylogenetic pattern of COG0055 is ----yqvcebrhujgp----xNumber of proteins in this genome belonging to this COG is 1","***** IPB000194 (ATP synthase alpha and beta subunit, N-terminal) with a combined E-value of 1.8e-119. IPB000194A 70-101 IPB000194B 134-171 IPB000194C 207-238 IPB000194D 249-290 IPB000194E 295-342***** IPB000790 (ATP synthase alpha subunit, C-terminal) with a combined E-value of 6.8e-11. IPB000790B 124-167 IPB000790C 203-248 IPB000790D 250-291 IPB000790E 321-358***** IPB003255 (ATP synthase beta subunit, C-terminal) with a combined E-value of 2.3e-10. IPB003255B 74-118 IPB003255C 120-165 IPB003255H 306-341","Residues 9-349 are 90% similar to a (TRANSPORT ION HYDROLASE HYDROGEN SUBUNIT SYNTHASE) protein domain (PD000090) which is seen in ATPB_STRMU.Residues 350-458 are identical to a (BETA ION HYDROLASE TRANSPORT) protein domain (PD000108) which is seen in ATPB_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 11 14:33:34 2002","Thu May 2 12:14:44 2002","Fri Apr 21 13:30:39 2006","Wed Mar 13 15:28:37 2002","Wed Mar 13 15:28:37 2002","Wed Mar 13 15:28:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1389 is paralogously related (blast p-value < 1e-3) to SMu1391, a predicted ATPase, alpha subunit.","Wed Mar 13 15:29:51 2002","Wed Apr 19 13:09:25 2006","pdb1SKYE Chain E, Crystal Structure Of The Nucleotide Free Al... 655 0.0pdb1MABB Chain B, Rat Liver F1-Atpase 537 9e-154pdb1NBMD Chain D, The Structure Of Bovine F1-Atpase Covalentl... 534 8e-153","SMU.1528c","","Residues 6 to 77 (E-value = 2.6e-24) place SMu1389 in the ATP-synt_ab_N family which is described as ATP synthase alpha/beta family, beta-barrel domain (PF02874)Residues 177 to 354 (E-value = 7e-88) place SMu1389 in the ATP-synt_ab family which is described as ATP synthase alpha/beta family, nucleotide-binding domain (PF00006)Residues 361 to 468 (E-value = 4.6e-48) place SMu1389 in the ATP-synt_ab_C family which is described as ATP synthase alpha/beta chain, C terminal domain (PF00306)","Wed Apr 19 13:09:25 2006","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C.Cloning and nucleotide sequence analysis of the Streptococcusmutans membrane-bound, proton-translocating ATPase operonGene 183 (1-2), 87-96 (1996)PubMed: 8996091","","Wed Mar 13 15:28:58 2002","Wed Mar 13 15:28:58 2002","1","","","SMU.1528c","96" "SMu1390","1456004","1455126","879","ATGACAGGCTCTCTTAGTGAAATCAAGGTAAGAATTACTTCAACACAAAAGACAGGAAAAATTACCAGTGCCATGAAAATGGTGTCTTCTGCTAAATTGGTTAAATCTGAACAAGCTGCTAAAGATTTTCAAATCTATGCTTCAAAAATTCGTCAAATCACAACGGATCTTTTACATTCTGATTTGAGGAAGGGTTCCAGCAATCCAATGCTTATTTCACGTCCAATTAAGAAGACGGCTTATATTGTCATTACTTCTGATAAAGGCTTGGTTGGTGCCTACAATTCAACCATCCTAAAGGCCGTTATGGATACCATTAAAGATTATCATCCAAAGGGTGATGATTACACCATTATTTCTATTGGTGGAATGGGATCGGACTTTTTCAGAGCTCGTCATATTCCAGTAGCCTTTGAATTACGTGGGTTGGAAGATAATCCCAGTTTTGAAGAAGTTAACCGTATCATTTCCAAGTCTGTTGAAATGTACAAAAATGAGCTTTTTGATGAACTTTATGTCTGTTACAGCCATCATATTAATAGTTTAACCAGTCAGGTTCGTGTTGAAAAAATGCTTCCTATCTCTGATTTGGATGCAGATGAAGCTAGTGAAGATAATGTCGCTAACTTCGAATTAGAACCTAGTCGAGAAGCTATTTTGGAACAACTCTTACCTCAATATGCAGAAAGTTTGATTTATGGAGCGATTATTGATGCTAAAACAGCAGAGCATGCTGCAGGTATGACAGCTATGCAGACTGCAACAGATAATGCAGACAAGGTCATTGAAGATTTAACAAAACTATATAATCGTGTGCGTCAAGCTGCGATTACACAAGAAATTACAGAGATTGTTGCGGGTGCCAATGCCCTAGACTAA","5.30","-6.58","32335","MTGSLSEIKVRITSTQKTGKITSAMKMVSSAKLVKSEQAAKDFQIYASKIRQITTDLLHSDLRKGSSNPMLISRPIKKTAYIVITSDKGLVGAYNSTILKAVMDTIKDYHPKGDDYTIISIGGMGSDFFRARHIPVAFELRGLEDNPSFEEVNRIISKSVEMYKNELFDELYVCYSHHINSLTSQVRVEKMLPISDLDADEASEDNVANFELEPSREAILEQLLPQYAESLIYGAIIDAKTAEHAAGMTAMQTATDNADKVIEDLTKLYNRVRQAAITQEITEIVAGANALD","1455141","For other 'unc' genes see SMu1388 (uncC); SMu1392 (uncH); SMu1393 (uncF); SMu1394 (uncB) and SMu1395 (uncE).See SMu1388 for proton-translocating ATPase, epsilon subunit. See SMu1389 for ATPase, beta subunit.See SMu1391 for ATP synthase alpha chain.See SMu1392 for ATPase, delta subunit.See SMu1394 for ATPase, a subunit.See SMu1393 for ATPase, b subunit.See SMu1395 for ATPase, c subunit.","ATPase, gamma subunit","Cytoplasm","Matches in gapped BLAST to ATP synthase gamma chain:residues 1-292 are 99% similar to the previously published enzyme in S.mutans (gi2493033),(gi7436160) and (gi1773265). Residues 1-292 are 77% similar to ATP synthase gamma chain in S.bovis (gi2662325). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0862 (1e-128).","

InterPro
IPR000131
Family

ATPase, F1 complex, gamma subunit
PR00126	$\"[76-95]T$ $\"[169-186]T$ $\"[238-257]T$ $\"[269-290]T$	ATPASEGAMMA
PTHR11693	$\"[1-292]T$	ATPase_F1_gamma
PF00231	$\"[3-291]T$	ATP-synt
TIGR01146	$\"[2-291]T$	ATPsyn_F1gamma
PS00153	$\"[277-290]T$	ATPASE_GAMMA
SSF52943	$\"[3-291]T$	ATPase_gamma

noIPR
unintegrated

unintegrated
G3DSA:3.40.1380.10	$\"[28-250]T$	G3DSA:3.40.1380.10
PTHR11693:SF10	$\"[1-292]T$	PTHR11693:SF10

","BeTs to 10 clades of COG0224COG name: FoF1-type ATP synthase gamma subunitFunctional Class: CThe phylogenetic pattern of COG0224 is ----yQvcebrhujgp----xNumber of proteins in this genome belonging to this COG is 1","***** IPB000131 (ATP synthase gamma subunit) with a combined E-value of 1.5e-81. IPB000131A 5-36 IPB000131B 76-100 IPB000131C 121-131 IPB000131D 169-194 IPB000131E 236-288","Residues 207-291 are 38% similar to a (ATP GAMMA SYNTHESIS CHAIN) protein domain (PD280948) which is seen in ATPG_RICPR.Residues 4-291 are 99% similar to a (GAMMA SYNTHASE CHAIN HYDROLASE) protein domain (PD001150) which is seen in ATPG_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 11:40:58 2006","Mon Sep 11 11:37:55 2006","Mon Sep 11 11:37:55 2006","Wed Mar 13 15:34:52 2002","Wed Mar 13 15:34:52 2002","Wed Mar 13 15:34:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1390 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 11 14:13:37 2002","Mon Sep 11 11:37:55 2006","pdb1MABG Chain G, Rat Liver F1-Atpase 96 4e-021pdb1E1QG Chain G, Bovine Mitochondrial F1-Atpase At 100k >gi... 96 4e-021","SMU.1529c","","Residues 3 to 291 (E-value = 8.3e-126) place SMu1390 in the ATP-synt family which is described as ATP synthase (PF00231)","Wed Mar 13 15:34:52 2002","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","","Wed Mar 13 15:34:52 2002","","1","","","SMU.1529c","333" "SMu1391","1457528","1456023","1506","TTGGCAATTAACGCACAAGAAATTAGCGCTTTAATTAAAAAGCAAATTGAAAACTTCCAGCCAAATTTTGATGTCACAGAGACTGGTGTTGTTACTTATATCGGTGATGGTATTGCTCGTGCTTGCGGACTTGATAATGCTATGAGCGGTGAATTGCTTGAGTTTGACAATGGAACTTTCGGAATGGCGCAAAACCTTGAGTCTAGTGATATCGGTATTATTATTCTTGGTGATTTTAATAGTATTCGTGAAGGTGACACGGTTAAGCGTACTGGTAAAATTATGGAAGTACCAGTCGGCCAGTCGCTTATTGGCCGAGTCGTTAATCCGCTTGGTCAGCCTGTTGATGGTCTGGGTGAAATTGAAACGACTGCGACACGTCCTGTCGAAGCGGCAGCTCCTGGTGTCATGCAGCGTCAATCTGTTTCTGAACCTTTGCAAACAGGAATAAAGGCCATTGATGCTTTGGTACCAATTGGCCGCGGACAGCGTGAATTGGTTATCGGAGACCGTCAAACCGGTAAGACTTCAATTGCCATTGATGCTATTATTAACCAAAAGGGACAAGATATGATTTGTATCTATGTTGCTATAGGTCAAAAGGAGTCTACTGTTCGCAGTCAAGTAGAGGTTCTTCGTAAATATGGCGCTCTTGATTATACTATTGTAGTGACAGCTTCGGCTTCGCAACCTTCACCTTTGCTTTACATTGCTCCTTATGCAGGTGTTGCAATGGCAGAAGAATTTATGTACAATGGCAAACATGCTTTGATTGTTTATGATGACTTATCAAAACAAGCAGTAGCTTATCGTGAACTTTCTTTGCTTTTGCGCCGTCCACCGGGACGTGAAGCCTATCCTGGGGATGTCTTCTATCTTCATAGCCGTCTTTTGGAACGTTCTGCTAAGCTTTCTGATGAGCTGGGCGGCGGCTCTATTACAGCCTTACCATTTATTGAAACGCAAGCAGGTGATATTTCAGCTTATATTGCAACCAACGTTATTTCCATCACTGACGGTCAAATTTTCCTTCAAGAAAATTTGTTTAACTCAGGAATCCGTCCAGCTATTGATGCCGGATCTTCTGTATCACGTGTTGGTGGTTCTGCCCAAATTAAGGCCATGAAAAAAGTTGCAGGAACTCTTCGTCTCGACTTGGCTTCTTATCGTGAACTTGAAGCCTTTACACAGTTTGGTTCTGATCTTGATTCAGCAACACAAGCTAAGCTTAATCGCGGACGTCGTACAGTAGAAGTTCTTAAACAAGGTCTTCACAAACCTTTGGCAGTTGAAAAACAAGTCTTGATTCTTTATGCTTTGACACATGGCTTTTTAGACAGTGTTCCTGTTGATGATATTTTGACTTTCCAAGATGATATGTTTGATTACATTGACTCACACGACGCTGATATCTTTGAAACGATTCGCACAACGAAAGATCTTCCAGAAGAAGCAGTGCTGGACAAAGCCATTCAGACTTTCAAAGATCAGTCACAATTTAGTTAA","4.70","-16.84","54344","MAINAQEISALIKKQIENFQPNFDVTETGVVTYIGDGIARACGLDNAMSGELLEFDNGTFGMAQNLESSDIGIIILGDFNSIREGDTVKRTGKIMEVPVGQSLIGRVVNPLGQPVDGLGEIETTATRPVEAAAPGVMQRQSVSEPLQTGIKAIDALVPIGRGQRELVIGDRQTGKTSIAIDAIINQKGQDMICIYVAIGQKESTVRSQVEVLRKYGALDYTIVVTASASQPSPLLYIAPYAGVAMAEEFMYNGKHALIVYDDLSKQAVAYRELSLLLRRPPGREAYPGDVFYLHSRLLERSAKLSDELGGGSITALPFIETQAGDISAYIATNVISITDGQIFLQENLFNSGIRPAIDAGSSVSRVGGSAQIKAMKKVAGTLRLDLASYRELEAFTQFGSDLDSATQAKLNRGRRTVEVLKQGLHKPLAVEKQVLILYALTHGFLDSVPVDDILTFQDDMFDYIDSHDADIFETIRTTKDLPEEAVLDKAIQTFKDQSQFS","1456038","See SMu1388 for proton-translocating ATPase, epsilon subunit. See SMu1389 for ATPase, beta subunit.See SMu1390 for ATPase, gamma subunit.See SMu1392 for ATPase, delta subunit.See SMu1394 for ATPase, a subunit.See SMu1393 for ATPase, b subunit.See SMu1395 for ATPase, c subunit.","ATP synthase alpha subunit","Cytoplasm","Matches in gapped BLAST to ATP synthase alpha subunit:residues 1-501 are 97% similar to the previously published enzyme in S.mutans (gi2493021),(gi7436076) and (gi1773264). Residues 1-500 are 88% similar to ATP synthase alpha subunit in S.bovis (gi2662324). This sequence corresponds to GI:24379919 in GenBank.This sequence is orthologous to Spy0758 and Sag0861.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0861 (0.0).","

InterPro
IPR000194
Domain

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding
PF00006	$\"[148-364]T$	ATP-synt_ab

InterPro
IPR000793
Domain

ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
PF00306	$\"[376-480]T$	ATP-synt_ab_C

InterPro
IPR004100
Domain

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal
PF02874	$\"[24-92]T$	ATP-synt_ab_N

InterPro
IPR005294
Family

ATPase, F1 complex, alpha subunit
PTHR15184:SF3	$\"[194-497]T$	ATP SYNTHASE ALPHA SUBUNIT MITOCHONDRIAL
TIGR00962	$\"[2-496]T$	atpA: ATP synthase F1, alpha subunit

noIPR
unintegrated

unintegrated
G3DSA:1.20.150.20	$\"[372-500]T$	no description
G3DSA:2.40.30.20	$\"[24-93]T$	no description
G3DSA:3.40.50.300	$\"[94-371]T$	no description
PTHR15184	$\"[194-497]T$	ATP SYNTHASE

","BeTs to 10 clades of COG0056COG name: FoF1-type ATP synthase alpha subunitFunctional Class: CThe phylogenetic pattern of COG0056 is ----yqvcebrhujgp----xNumber of proteins in this genome belonging to this COG is 1","***** IPB000790 (ATP synthase alpha subunit, C-terminal) with a combined E-value of 4.6e-223. IPB000790A 27-77 IPB000790B 138-181 IPB000790C 216-261 IPB000790D 262-303 IPB000790E 337-374 IPB000790F 375-428***** IPB000194 (ATP synthase alpha and beta subunit, N-terminal) with a combined E-value of 2.9e-116. IPB000194A 85-116 IPB000194B 148-185 IPB000194C 220-251 IPB000194D 261-302 IPB000194E 311-358***** IPB003255 (ATP synthase beta subunit, C-terminal) with a combined E-value of 1.7e-21. IPB003255B 89-133 IPB003255C 134-179 IPB003255D 188-221 IPB003255F 250-278 IPB003255H 322-357","Residues 370-496 are identical to a (CF1 ION HYDROLASE TRANSPORT) protein domain (PD001099) which is seen in ATPA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 11 14:35:13 2002","Thu May 2 12:15:47 2002","Fri Apr 21 13:27:32 2006","Wed Mar 13 15:39:04 2002","Wed Mar 13 15:39:04 2002","Wed Mar 13 15:39:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1391 is paralogously related (blast p-value < 1e-3) to SMu1389, a predicted ATPase, beta subunit.","Wed Mar 13 15:39:19 2002","Fri Apr 21 13:26:05 2006","pdb1SKYB Chain B, Crystal Structure Of The Nucleotide Free Al... 715 0.0pdb1E1QA Chain A, Bovine Mitochondrial F1-Atpase At 100k >gi... 545 6e-156pdb1EFRC Chain C, Bovine Mitochondrial F1-Atpase Complexed Wi... 545 6e-156","SMU.1530c","","Residues 24 to 92 (E-value = 3.1e-19) place SMu1391 in the ATP-synt_ab_N family which is described as ATP synthase alpha/beta family, beta-barrel domain (PF02874)Residues 190 to 370 (E-value = 5.7e-103) place SMu1391 in the ATP-synt_ab family which is described as ATP synthase alpha/beta family, nucleotide-binding domain (PF00006)Residues 376 to 480 (E-value = 3.2e-33) place SMu1391 in the ATP-synt_ab_C family which is described as ATP synthase alpha/beta chain, C terminal domain (PF00306)","Fri Apr 21 13:26:05 2006","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","","Wed Mar 13 15:39:04 2002","","1","","","SMU.1530c","95" "SMu1392","1458080","1457544","537","ATGGATAAAAAAACGCAGGCTGTGACTGAGATCTATGCCAAGAGTCTTGTTGAAGTCGCTCTTGAAAGAGATTCAGTCCCTATTATCTATGATGAAGTTAGAGCAATTTTGAGTGTTCTTGATGATCAGCAAGTACAAGATTTTTTAGCAAGCAAGGCAATTGATCTGTCTGCTAAATCTGAAGTTGTAAGACTGTTTCAAGAGTCTTGTTCGAACTATATGAAACAGTTTCTTGAGATTATCTTACAAAATGAACGTCAGCAGCTTCTTTATCTTATAATGAAAGAAGTTTTGAAAGAGCTCAGTCTTAAGACACATATCTTTGATATTGAGGTAACGACAGCTGTCGCTCTTTCAGATGATCAAAAAGAACGGTTGACAGCACTTGTTGAAAAGAAATTTGCCCTAACCAAACGAAATCTTATTGAAAAAATTGATGATGAAATCATTGGTGGTTTTATTATTAAAGCAAATAATAAGGTAATTGACACTAGTATTCGTAGCCAATTACAAGAATTAAAAATGAATTTGAAATAG","5.10","-3.80","20433","MDKKTQAVTEIYAKSLVEVALERDSVPIIYDEVRAILSVLDDQQVQDFLASKAIDLSAKSEVVRLFQESCSNYMKQFLEIILQNERQQLLYLIMKEVLKELSLKTHIFDIEVTTAVALSDDQKERLTALVEKKFALTKRNLIEKIDDEIIGGFIIKANNKVIDTSIRSQLQELKMNLK","1457559","For other 'unc' genes see SMu1388 (uncC); SMu1390 (uncG); SMu1393 (uncF); SMu1394 (uncB) and SMu1395 (uncE).See SMu1388 for proton-translocating ATPase, epsilon subunit. See SMu1389 for ATPase, beta subunit.See SMu1390 for ATPase, gamma subunit.See SMu1391 for ATP synthase alpha chain.See SMu1394 for ATPase, a subunit.See SMu1393 for ATPase, b subunit.See SMu1395 for ATPase, c subunit.","ATPase delta subunit","Cytoplasm","Matches in gapped BLAST to ATP synthase delta subunit:residues 1- 178 are 98% similar to the previously published enzyme in S.mutans (gi2493037),(gi7436128) and (gi1773263). Residues 1-178 are 55% similar to ATP synthase delta subunit in S.bovis (gi3913121). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0860 (9e-43).","

InterPro
IPR000711
Family

ATPase, F1 complex, OSCP/delta subunit
PR00125	$\"[8-27]T$ $\"[75-86]T$ $\"[137-152]T$ $\"[152-170]T$	ATPASEDELTA
G3DSA:1.10.520.20	$\"[3-107]T$	ATPase_F1_OSCP/d
PTHR11910	$\"[12-178]T$	ATPase_F1_OSCP/d
PF00213	$\"[8-177]T$	OSCP
TIGR01145	$\"[8-177]T$	ATP_synt_delta
SSF47928	$\"[3-107]T$	ATPsynt_OSCP

","BeTs to 8 clades of COG0712COG name: FoF1-type ATP synthase delta subunitFunctional Class: CThe phylogenetic pattern of COG0712 is ----yqvcebrh--gp----xNumber of proteins in this genome belonging to this COG is 1","***** IPB000711 (ATP synthase, delta (OSCP) subunit) with a combined E-value of 2e-15. IPB000711 145-173","Residues 5-81 are 49% similar to a (DELTA SYNTHASE HYDROGEN ION) protein domain (PD404410) which is seen in ATPD_STRBO.Residues 1-101 are 99% similar to a (DELTA ATP SYNTHESIS SUBUNIT) protein domain (PD414630) which is seen in ATPD_STRMU.Residues 106-173 are 97% similar to a (DELTA SYNTHASE CHAIN HYDROLASE) protein domain (PD001250) which is seen in ATPD_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 11:42:13 2006","Thu May 2 12:16:26 2002","Mon Sep 11 11:42:13 2006","Wed Mar 13 15:43:56 2002","Wed Mar 13 15:43:56 2002","Wed Mar 13 15:43:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1392 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 11 14:15:04 2002","","No significant hits to the NCBI PDB database.","SMU.1531c","","Residues 8 to 177 (E-value = 1.9e-25) place SMu1392 in the OSCP family which is described as ATP synthase delta (OSCP) subunit (PF00213)","Wed Mar 13 15:43:56 2002","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","","Wed Mar 13 15:43:56 2002","","1","","","SMU.1531c","922" "SMu1393","1458577","1458080","498","ATGTCAACACTTATTAATGGAACAAGTCTAGGCAATTTGCTTATCGTGACAGGATCTTTTATCCTTTTATTACTTCTGGTTAAGAAATTTGCTTGGTCTCAGCTGGCAGCTATTTTCAAAGCACGAGAAGAAAAAATTGCAAAGGATATTGATGATGCTGAAAATTCACGTCAAAATGCTCAGGTTTTAGAGAATAAACGTCAAGTTGAGCTTAACCAAGCTAAGGATGAAGCTGCCCAAATTATTGATAACGCTAAGGAAACTGGTAAAGCTCAAGAGTCTAAGATTATAACAGAAGCTCATGAGGAAGCCGGTCGTCTAAAAGATAAGGCCAATCAAGATATTGCTACAAGCAAGGCAGAAGCCCTATCAAGCGTTAAGGCAGATGTGGCAGATCTTAGTGTTCTTTTAGCCGAAAAAATTATGGCAAAAAATCTTGATAAGACAGCTCAAGGTGACTTAATTGATAGCTACTTAGACAAATTAGGAGATGCCTAA","4.90","-4.75","17906","MSTLINGTSLGNLLIVTGSFILLLLLVKKFAWSQLAAIFKAREEKIAKDIDDAENSRQNAQVLENKRQVELNQAKDEAAQIIDNAKETGKAQESKIITEAHEEAGRLKDKANQDIATSKAEALSSVKADVADLSVLLAEKIMAKNLDKTAQGDLIDSYLDKLGDA","1458095","For other 'unc' genes see SMu1388 (uncC); SMu1390 (uncG); SMu1392 (uncH); SMu1394 (uncB) and SMu1395 (uncE).","ATPase, b subunit","Periplasm, Membrane","Matches in gapped BLAST to ATP synthase ATPase, b subunit:residues 1-165 are 99% similar to the previously published enzyme in S.mutans (gi2493070),( gi7436260) and (gi1773262).Residues 1-148 are 69% similar to ATP synthase b subunit in S.bovis (gi2662322). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0859 (3e-54).","

InterPro
IPR002146
Family

ATPase, F0 complex, subunit B/B', bacterial and chloroplast
PF00430	$\"[12-143]T$	ATP-synt_B

InterPro
IPR005864
Family

ATPase, F0 complex, subunit B, bacterial
TIGR01144	$\"[16-162]T$	ATP_synt_b

noIPR
unintegrated

unintegrated
SSF81573	$\"[68-128]T$	SSF81573

","BeTs to 7 clades of COG0711COG name: FoF1-type ATP synthase B subunitFunctional Class: CThe phylogenetic pattern of COG0711 is -----QvCebRhujgp----xNumber of proteins in this genome belonging to this COG is 1","***** IPB002146 (ATP synthase B/B' CF(0)) with a combined E-value of 2.5e-12. IPB002146 17-55","Residues 42-141 are identical to a (SYNTHASE SUBUNIT CHAIN TRANSMEMBRANE) protein domain (PD001731) which is seen in ATPF_STRMU.Residues 42-133 are 70% similar to a (B SYNTHASE CHAIN SUBUNIT) protein domain (PD201732) which is seen in O50155_STRBO.Residues 13-161 are 27% similar to a (B SYNTHASE SUBUNIT CHAIN) protein domain (PD132495) which is seen in Q9RMB4_ACEWO.Residues 20-162 are 31% similar to a (B CHAIN SYNTHASE ATP) protein domain (PD022489) which is seen in Q9PR09_UREPA.Residues 40-122 are 44% similar to a (B SYNTHASE ION CHAIN) protein domain (PD403102) which is seen in ATPF_ENTHR.Residues 44-151 are 30% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in ATPF_SYNP1.Residues 38-131 are 32% similar to a (MYOSIN CHAIN HEAVY ATP-BINDING) protein domain (PD000023) which is seen in ATPF_BACCA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jul 7 17:26:26 2006","Wed Mar 13 15:50:22 2002","Fri Jul 7 17:26:26 2006","Wed Mar 13 15:47:30 2002","Fri Jul 7 17:26:26 2006","Wed Mar 13 15:47:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1393 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 13 15:50:22 2002","","No significant hits to the NCBI PDB database.","SMU.1532c","","Residues 12 to 143 (E-value = 2.9e-28) place SMu1393 in the ATP-synt_B family which is described as ATP synthase B/B' CF(0) (PF00430)","Fri Jul 7 17:26:26 2006","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","","Wed Mar 13 15:50:22 2002","","1","","","SMU.1532c","790" "SMu1394","1459314","1458595","720","TTGGAAAAAACAATAAATCCAACGGTTAAATTCTTAGGTATTGAGTTTGACTTAACCATCTTGATGATGTCTCTCTTAGTTGTTCTTATTGCATTCTTATTTGTCTTTTGGACAAGCCGCCATCTGAAAATAAAGCCTACGGGCAGACAAAATGTTTTAGAATGGATCTATGATTTTGTCCTTGGAATTATCAAGCCTAATTTAGGTTCTTATACTAAAAATTACAGCCTATTTGCTTTTTGTCTCTTCCTTTTTGTTTTTGTTGCTAACAATATTGGTTTATTAACAAAGATTCAAGTTAAAGATTATAATTTATGGACTTCCCCAACAGCAAATTTTGCAGTTGATTTTGGTCTTTCTTTAATGGTGGCGGTAATCTGTCACTTTGAAGGTATTCGTAAGCATGGCTTGAAAACATACTTAAAGGATTATTTAGAACCGACAGCAGCTATGTTGCCTATGAATCTCTTAGAAGAACTAACGAATATTATTTCACTGTCTCTTCGTTTATATGGTAATATTTATGCTGGTGAAGTTGTTATGGCGCTTTTGGTACAGTTTGCTGATTTTAGCCCGTATGCGACACCAATAGCCTTTCTGCTTAACATGGCTTGGATTGGATTTTCTATTTTCATCTCAGGAATACAAGCCTATGTCTTTGTTCTTTTAACGACGACTTATATTGGTAAAAAGGTCAATATTGATACTAAAGGCAATTAA","9.10","3.62","27057","MEKTINPTVKFLGIEFDLTILMMSLLVVLIAFLFVFWTSRHLKIKPTGRQNVLEWIYDFVLGIIKPNLGSYTKNYSLFAFCLFLFVFVANNIGLLTKIQVKDYNLWTSPTANFAVDFGLSLMVAVICHFEGIRKHGLKTYLKDYLEPTAAMLPMNLLEELTNIISLSLRLYGNIYAGEVVMALLVQFADFSPYATPIAFLLNMAWIGFSIFISGIQAYVFVLLTTTYIGKKVNIDTKGN","1458610","For other 'unc' genes see SMu1388 (uncC); SMu1390 (uncG); SMu1392 (uncH); SMu1393 (uncF) and SMu1395 (uncE).See SMu1388 for proton-translocating ATPase, epsilon subunit. See SMu1389 for ATPase, beta subunit.See SMu1390 for ATPase, gamma subunit.See SMu1391 for ATP synthase alpha chain.See SMu1392 for ATPase, delta subunit.See SMu1393 for ATPase, b subunit.See SMu1395 for ATPase, c subunit.","ATP synthase subunit A","Membrane, Cytoplasm","Matches in gapped BLAST to ATP synthase a subunit:residues 1-239 are 89% similar to the previously published enzyme in S.mutans (gi2493056),(gi7436204) and (gi1773261) Residues 1-235 are 50% similar to ATP synthase a subunit in S.bovis (gi2662321). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0858 (7e-74).","

InterPro
IPR000568
Family

ATPase, F0 complex, subunit A
PR00123	$\"[78-94]T$ $\"[146-161]T$ $\"[162-184]T$ $\"[215-230]T$	ATPASEA
PF00119	$\"[14-230]T$	ATP-synt_A
TIGR01131	$\"[7-232]T$	ATP_synt_6_or_A: ATP synthase F0, A subunit
PS00449	$\"[165-174]T$	ATPASE_A

noIPR
unintegrated

unintegrated
signalp	$\"[1-41]?$	signal-peptide
tmhmm	$\"[19-37]?$ $\"[75-95]?$ $\"[114-132]?$ $\"[179-199]?$ $\"[205-227]?$	transmembrane_regions

","BeTs to 9 clades of COG0356COG name: FoF1-type ATP synthase a subunitFunctional Class: CThe phylogenetic pattern of COG0356 is -----qvcebrhujgp----xNumber of proteins in this genome belonging to this COG is 1","***** IPB000568 (ATP synthase A subunit) with a combined E-value of 1.4e-30. IPB000568A 81-102 IPB000568B 149-184 IPB000568C 208-228","Residues 151-235 are identical to a (SYNTHASE CHAIN TRANSMEMBRANE ION) protein domain (PD010746) which is seen in ATP6_STRMU.Residues 156-232 are 42% similar to a (ION CF0 SYNTHASE CHAIN) protein domain (PD407332) which is seen in ATPI_CHLVU.Residues 100-149 are identical to a (SYNTHASE CHAIN TRANSMEMBRANE ION) protein domain (PD415462) which is seen in ATP6_STRMU.Residues 153-234 are 34% similar to a (ION CHAIN CF0 SYNTHASE) protein domain (PD415086) which is seen in ATP6_MYCPN.Residues 37-94 are 77% similar to a (SYNTHASE CHAIN CF0 TRANSPORT) protein domain (PD002001) which is seen in ATP6_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jul 28 12:30:27 2006","Fri Jul 28 12:30:27 2006","Fri Jul 28 12:30:27 2006","Wed Mar 13 16:01:37 2002","Wed Mar 13 16:01:37 2002","Wed Mar 13 16:01:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1394 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 13 16:04:47 2002","Fri Jul 28 12:30:27 2006","pdb1C17M Chain M, A1c12 Subcomplex Of F1fo Atp Synthase 67 3e-012","SMU.1533c","","Residues 72 to 230 (E-value = 1.2e-42) place SMu1394 in the ATP-synt_A family which is described as ATP synthase A chain (PF00119)","Wed Mar 13 16:01:37 2002","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","","Wed Mar 13 16:04:47 2002","","1","","","SMU.1533c","668" "SMu1395","1459547","1459344","204","ATGTTGAATTTAAAGATTTTAGCACTTGGGATTGCTGTTTTAGGCGTTAGCCTTGGTGAAGGAATTTTAGTTGCTAATATTGCAAAATCTGCAGCTCGTCAGCCTGAAATGTATGGTAAATTACAAACGCTCATGATTATGGGTGTTGCCTTTATTGAAGGTACCTTTTTCGTGCTTCTTGCTTCAACATTCTTTGTTGGCTGA","9.40","0.98","7042","MLNLKILALGIAVLGVSLGEGILVANIAKSAARQPEMYGKLQTLMIMGVAFIEGTFFVLLASTFFVG","1459359","For other 'unc' genes see SMu1388 (uncC); SMu1390 (uncG); SMu1392 (uncH); SMu1393 (uncF) and SMu1394 (uncB).See SMu1388 for proton-translocating ATPase, epsilon subunit. See SMu1389 for ATPase, beta subunit.See SMu1390 for ATPase, gamma subunit.See SMu1391 for ATP synthase alpha chain.See SMu1392 for ATPase, delta subunit.See SMu1393 for ATPase, b subunit.See SMu1394 for ATPase, a subunit.","ATPase, c subunit","Membrane, Extracellular","Matches in gapped BLAST to ATP synthase beta subunit:residues 1-67 are 100% similar to the previously published enzyme in S.mutans (gi|2493075|),(gi|7436175|) and (gi|1773260|) Residues 1-67 are 92% similar to ATP synthase c subunit in S.bovis (gi|2662320|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0857 (8e-25).","

InterPro
IPR000454
Family

ATPase, F0 complex, subunit C
PR00124	$\"[4-23]T$ $\"[25-40]T$ $\"[42-67]T$	ATPASEC
PS00605	$\"[32-53]T$	ATPASE_C

InterPro
IPR002379
Family

ATPase, F0/V0 complex, subunit C
G3DSA:1.20.20.10	$\"[7-65]T$	ATPase_F0/V0_c
PF00137	$\"[7-55]T$	ATP-synt_C
SSF81333	$\"[7-66]T$	ATPase_F0/V0_c

","BeTs to 11 clades of COG0636COG name: FoF1-type ATP synthase c subunit/Vacuolar ATPase/archaeal ATP synthase K subunitFunctional Class: CThe phylogenetic pattern of COG0636 is AmtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000454 (Eubacterial and plasma membrane ATP synthase subunit C) with a combined E-value of 1.5e-20. IPB000454 8-61","Residues 2-66 are identical to a (LIPID-BINDING C ION TRANSMEMBRANE) protein domain (PD399852) which is seen in ATPL_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:14:59 2002","Wed Mar 13 16:10:01 2002","Thu Oct 17 15:14:59 2002","Wed Mar 13 16:10:01 2002","Wed Mar 13 16:10:01 2002","Wed Mar 13 16:10:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1395 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 11 14:16:28 2002","","No significant hits to the NCBI PDB database.","SMU.1534c","","Residues 4 to 61 (E-value = 4.7e-05) place SMu1395 in the ATP-synt_C family which is described as ATP synthase subunit C (PF00137)","Wed Mar 13 16:10:01 2002","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","","Wed Mar 13 16:10:01 2002","","1","","","SMU.1534c","921" "SMu1396","1462182","1459786","2397","ATGCAACTAACAAAGGAAAAATTCATTCGTGACTTTAAAGACACTCTGCATGAAGAGCAATTAATTAAGATACCTGAAGCAACACCGACGGAACTTTTTGCTTCTTTGGCTAAGGTTGTTCGTAAATATTATACGCCGCTTTGGTTAGAAAGAAATCGCAAGATTTCCCAAAATCAGCAGAAGGTAGCTTATTATTTTTCAATTGAGTTTCTTCCCGGACGTATGCTGGAAACTAATTTACTTAATCTAGGTATCTTAGATACGGTTAAGGAAGGGTTTGCTGAACTTGGTGTCAATTTTGAGGACGTTAAAAATGCTGAACATGATATGGCACTTGGTAATGGCGGTCTCGGCCGTCTGGCAGCAGCCTTTATGGATTCATTAGCGACAACTGGTTATCCCGGTTTTGGGAATGGCCTTCGTTATAAATATGGTCTTTTTAAGCAACGTATCGTTGATGGTTATCAGGTGGAGCTGCCAGACTCTTGGTTTGGCTCTGTCGGCAATGTTTGGGAGACACGTAAGGATCATGATGCTGTTGAAGTAAAACTTTTTGGCAATGTTTATTTGCAGGCTAATGAAAGAGGACGCATTGTTCCGGTTTATGATGGCGCACAAATCCTGCGTGCTATTCCTTATGATGTTCCGCAAATTGGTTTTGGTAATGATAACATTAATAATTTGCGTCTTTGGGATGTTGAGATTCCTGAAGAATGTGAATTGAATTACCCAACTCTGGAATCACGTCGTCGTGTTAAAAATATTACGGCTATTCTCTACCCGGATGATTCTAATTATGAAGGTAAAGAGTTACGCTTGATTCAAGAATACTTTATGACAAGTGCTGGTTTACAAACCATTATTAAATCTTATCTTAAACAAGGTTTACCGCTAGAAAGAATTCACGAAAAAATTTCTGTTCATATCAATGATACCCATCCAGCAGTAGCACCTGCTGAGTTCATGCGGTTGTTGATTGATGAATACGATCTTGAGTGGGATCAAGCATGGGAAACGACTGTGCAAACGATGAGTTATACTAACCATACTATTCTTTCAGAAGCTCTTGAAAAGTGGGATGCTGGGCTTTTCAAGAATGTCTTGCCTCGTGTTTATCAAATTATTCTGGAAATTGATAACCGTTTTGTTGCTGGTTTAGCCCAAAAAGGCATTGATCCTCAAATTATTGAAAATACTCGCATTGTTAAAGATAATCAAATTCATATGGCAAATTTGGCTATCATTGGCGGTCACTCTGTTAATGGTGTTGCGAAGCTTCATACAGAACTGCTCAAAGAAGATACCTTGCATGATTTTTATACCCTTTATCCTGGAAAATTCAACAATAAGACTAATGGTATCGTACAGCGTCGTTGGACACAAATTGCAGCACCAGAATTATCTGCAGCGCTTGATCAAACGATTGGTAATAGCTGGCGCACAGATATTCACGAATTGAGAAAGTTAAATGATTTTGCCAATGATTCTGCTGTACTTGATCATTTTTATCAGGTTAAACAAGATGCCAAGGCAAAATTAGCTGCTTATATAAAAGAATCAACAGGCGTGGAGGTCTCAACAGATGCTATCTTTGATGTACAAGTTAAGCGTCTGCATGCCTATAAACGTCAGCTGCTAAATGTTCTTCATATTGTGAAATTGTATTGGGATCTAAAGGATAATCCAAATCTTGATATGGTTCCGCGTGTCTTTATCTTTGGAGCCAAAGCAGCACCGGGATATCATTTTGCCAAATCTGTGATTAAAATTATTAATGAATTAGCTAATCTTATTAATAGCGATGAAAGCCTTCAAGGAAAACTCAAAGTTGTCTTTCTTGAAAATTATAATGTTAGTCTAGCGGAACTTATTATTCCAGCAGCCAATGTTTCTGAACAGATCTCTCTAGCTTCCAAGGAAGCCTCCGGAACGTCTAACATGAAATTCATGATGACGGGTGCTGTTACTTTAGCAACGCTTGACGGTGCTAATATTGAGATCAAAGATGAAGTTGGTGATGAGAATATTGTCATCTTTGGTATGACCAAGGATGATGTCTACCGTCATTATGAAAATCATGATTATTACTCACGCGGTGTCTATGAATCTAATCCTGTTATCAAACGTGTTGTTGATACCTTTATCAATGGAACGATTCCTAATAGTCAAAGTGAAGGGACTGAAATTTATGAAGCCCTGATTACCCATAATGATGAATATTTCTTACTTGAAGATTTCATAGCCTATGTGCAGGCTCAAGAAAAGATTGATGCTCTTTATCGTGATAAAGAAACTTGGTCGCGTATGAGTTTGTGTAATATTGCTAACTCTGATAAATTTACTTCAGATGATACGATTACACAATATGCTAAAGAAATTTGGCATTTAGAAATTTAA","5.20","-23.18","91045","MQLTKEKFIRDFKDTLHEEQLIKIPEATPTELFASLAKVVRKYYTPLWLERNRKISQNQQKVAYYFSIEFLPGRMLETNLLNLGILDTVKEGFAELGVNFEDVKNAEHDMALGNGGLGRLAAAFMDSLATTGYPGFGNGLRYKYGLFKQRIVDGYQVELPDSWFGSVGNVWETRKDHDAVEVKLFGNVYLQANERGRIVPVYDGAQILRAIPYDVPQIGFGNDNINNLRLWDVEIPEECELNYPTLESRRRVKNITAILYPDDSNYEGKELRLIQEYFMTSAGLQTIIKSYLKQGLPLERIHEKISVHINDTHPAVAPAEFMRLLIDEYDLEWDQAWETTVQTMSYTNHTILSEALEKWDAGLFKNVLPRVYQIILEIDNRFVAGLAQKGIDPQIIENTRIVKDNQIHMANLAIIGGHSVNGVAKLHTELLKEDTLHDFYTLYPGKFNNKTNGIVQRRWTQIAAPELSAALDQTIGNSWRTDIHELRKLNDFANDSAVLDHFYQVKQDAKAKLAAYIKESTGVEVSTDAIFDVQVKRLHAYKRQLLNVLHIVKLYWDLKDNPNLDMVPRVFIFGAKAAPGYHFAKSVIKIINELANLINSDESLQGKLKVVFLENYNVSLAELIIPAANVSEQISLASKEASGTSNMKFMMTGAVTLATLDGANIEIKDEVGDENIVIFGMTKDDVYRHYENHDYYSRGVYESNPVIKRVVDTFINGTIPNSQSEGTEIYEALITHNDEYFLLEDFIAYVQAQEKIDALYRDKETWSRMSLCNIANSDKFTSDDTITQYAKEIWHLEI","1459801","For other 'glg' genes see SMu1397 (glgA); SMu1398 (glgD); SMu1399 (glgC); SMu1400 (glgB); SMu1422 (glg) and SMu1539 (glg3). ","glycogen phosphorylase","Cytoplasm","Matches in gapped BLAST to glycogen phosphorylase:residues 628-798 are 99% similar to the previously published enzyme in S.mutans (gi|7433828|).Residues 1-797 are 56% similar to glycogen phosphorylase in Lactococcus lactis (gi|15672682|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1438 (1e-133).","

InterPro
IPR000811
Family

Glycosyl transferase, family 35
PIRSF000460	$\"[3-798]T$	Pprylas_GlgP
PTHR11468	$\"[36-797]T$	Glyco_trans_35
PF00343	$\"[92-798]T$	Phosphorylase

InterPro
IPR011833
Family

Glycogen/starch/alpha-glucan phosphorylase
TIGR02093	$\"[4-796]T$	P_ylase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2000	$\"[4-483]T$	G3DSA:3.40.50.2000
SSF53756	$\"[3-797]T$	SSF53756

","BeTs to 9 clades of COG0058COG name: Glucan phosphorylaseFunctional Class: GThe phylogenetic pattern of COG0058 is -m-kyq-CEbrh------in-Number of proteins in this genome belonging to this COG is 2","***** IPB000811 (Glycosyltransferase family 35) with a combined E-value of 3.8e-260. IPB000811A 61-103 IPB000811B 107-146 IPB000811C 202-234 IPB000811D 252-291 IPB000811E 333-379 IPB000811F 407-459 IPB000811G 525-559 IPB000811H 568-611 IPB000811I 625-679 IPB000811J 760-798","Residues 4-265 are 46% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN GLYCOSYLTRANSFERASE) protein domain (PD002266) which is seen in Q9CHM8_LACLA.Residues 377-450 are 41% similar to a (PHOSPHORYLASE PHOSPHATE STARCH PYRIDOXAL) protein domain (PD404360) which is seen in O24363_SPIOL.Residues 369-449 are 62% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN PYRIDOXAL TRANSFERASE) protein domain (PD002287) which is seen in Q9CHM8_LACLA.Residues 646-797 are 51% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN PHOSPHATE CARBOHYDRATE) protein domain (PD002288) which is seen in Q9CHM8_LACLA.Residues 451-645 are 58% similar to a (PHOSPHORYLASE GLYCOGEN METABOLISM) protein domain (PD010784) which is seen in Q9CN90_PASMU.Residues 451-644 are 69% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN PHOSPHATE CARBOHYDRATE) protein domain (PD001956) which is seen in Q9CHM8_LACLA.Residues 268-368 are 55% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN GLYCOSYLTRANSFERASE) protein domain (PD001939) which is seen in PHSG_CHLTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:14:18 2002","Wed Mar 13 16:13:48 2002","Thu Oct 17 15:14:18 2002","Wed Mar 13 16:13:48 2002","Wed Mar 13 16:13:48 2002","Wed Mar 13 16:13:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1396 is paralogously related (blast p-value < 1e-3) to SMu1422, also a predicted glycogen phosphorylase.","Wed Mar 13 16:17:26 2002","Wed Mar 13 16:13:48 2002","pdb|1C8L|A Chain A, Synergistic Inhibition Of Glycogen Phosphor... 615 5e-177pdb|1E1Y|A Chain A, Lavopiridol Inhibits Glycogen Phosphorylase... 615 5e-177pdb|1C50|A Chain A, Identification And Structural Characterizat... 615 8e-177","SMU.1535c","","No significant hits to the Pfam 11.0 database","Wed Mar 13 16:13:48 2002","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","","Wed Mar 13 16:15:33 2002","","1","","","SMU.1535c","" "SMu1397","1463643","1462213","1431","ATGAAAATCTTATTTGTAGCAGCGGAAGGGGCTCCTTTTGCAAAGACAGGCGGTCTGGGCGATGTTATTGGTGCCTTGCCCAAATCCCTTGTGAAAAATAATAATGAAGTCAGTGTTATCCTTCCTTATTATGATGTTGTTGATGCTAAATTTGGTGACCAAATAGAAGATCTGTTCTACTTTTTCACCAATGTCGGCTGGCGTCGTGAATATGTTGGTATCAAACATATCTTCAGAGATGGCGTTGACTTTTACTTTATTGACAATAAGCATTATTTTTATCGTGGTCAAATCTATGGTGAATTTGATGATGGTGAACGCTTTGCTTACTTCCAATTAGCTGCTTTAGAAGCTATGGAAAAAATTCAATTTATTCCGGATATTCTTCATGTCCATGATTATCACACCGCCATGATTCCTTACTTGCTAAAGGAAAAATATCATTGGATTAATGCTTATCATGGGATTAAGACAGTATTTACCATTCATAATATCGAGTTTCAAGGTCAATTCAATCCTTCTATGTTAGGAGAGCTTTTTGGAGTTGGTGATGAGCGTTATCGTGATGGGACGCTGCGGTGGAATGATTGCCTCAACTGGATGAAGGCAGCGGTGCTCTATGCAGATCGTGTCACCACTGTTTCACCATCTTATGCTAAAGAAATTATGACTCCTGAATTTGGTAAAGGACTGGATCAAATTATGCGGATGGAATCAGGTAAGTTAAGTGGTGTTGTCAATGGTATTGACACGGACTTATTTGATCCGGAAACAGATCCACATCTGGCAGTGCATTTTTCAAAAGATGATCTGTCAGGTAAAGCTAAAAATAAAGCAGCCTTGCAGGAGCGTGTTGGTTTACCAGTACGTGAGGATGTTCCTTTGGTTGGTATTGTCTCTCGTCTGACAGATCAGAAGGGTTTTCAGTTGGTTGTTGATCAACTTAATACAATGATGCAACTGGATTTACAGATTGTTTTACTAGGAACAGGCTATGCTGATTTTGAAAATGCTTTTGCTTGGTTCGGTCATGCTTATCCAGACAAAATGTCAGCCAATATCACTTTTGATTTAGAATTAGCTCAGCAAATTTATGCTGCCAGCGATATTTTCTTAATGCCGAGTGCATTTGAGCCTTGTGGCTTGTCACAAATGATGGCTATGCGTTATGGTACCTTACCGCTTGTACATGAAGTAGGCGGACTTCGGGATACTGTTATTCCTTATAATGAGTTTGAAAAGACAGGAACAGGTTTTGGTTTCCAAGACTTCTCAGGTTATTGGCTGACCAAAACGCTTGAAGCTGCGCTAGATGTCTATTATAATAGAAAAGAAGACTGGAAAATTCTCCAAAAAAATGCGATGACAACTGACTTCTCTTGGGATACAGCCAGTCAATCTTATGAACATCTATATAAAGAACTAGCTTAG","4.90","-18.93","54302","MKILFVAAEGAPFAKTGGLGDVIGALPKSLVKNNNEVSVILPYYDVVDAKFGDQIEDLFYFFTNVGWRREYVGIKHIFRDGVDFYFIDNKHYFYRGQIYGEFDDGERFAYFQLAALEAMEKIQFIPDILHVHDYHTAMIPYLLKEKYHWINAYHGIKTVFTIHNIEFQGQFNPSMLGELFGVGDERYRDGTLRWNDCLNWMKAAVLYADRVTTVSPSYAKEIMTPEFGKGLDQIMRMESGKLSGVVNGIDTDLFDPETDPHLAVHFSKDDLSGKAKNKAALQERVGLPVREDVPLVGIVSRLTDQKGFQLVVDQLNTMMQLDLQIVLLGTGYADFENAFAWFGHAYPDKMSANITFDLELAQQIYAASDIFLMPSAFEPCGLSQMMAMRYGTLPLVHEVGGLRDTVIPYNEFEKTGTGFGFQDFSGYWLTKTLEAALDVYYNRKEDWKILQKNAMTTDFSWDTASQSYEHLYKELA","1462228","For other 'glg' genes see SMu1396 (glgP); SMu1398 (glgD); SMu1399 (glgC); SMu1400 (glgB); SMu1422 (glg) and SMu1539 (glg3). ","glycogen synthase","Cytoplasm","Several matches in gapped BLAST to glycogen synthase: residues 1-475 are 71% similar to the enzyme in S.pneumoniae (gi|15900991|) and are 57% similar to the protein from Lactococcus lactis (gi|15672681|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0856 (0.0).","

InterPro
IPR001296
Domain

Glycosyl transferase, group 1
PF00534	$\"[280-457]T$	Glycos_transf_1

InterPro
IPR011835
Domain

Glycogen/starch synthases, ADP-glucose type
TIGR02095	$\"[1-475]T$	glgA

InterPro
IPR013534
Domain

Starch synthase catalytic region
PF08323	$\"[2-237]T$	Glyco_transf_5

noIPR
unintegrated

unintegrated
PTHR12526	$\"[2-61]T$ $\"[96-261]T$ $\"[282-475]T$	PTHR12526
PTHR12526:SF17	$\"[2-61]T$ $\"[96-261]T$ $\"[282-475]T$	PTHR12526:SF17
SSF53756	$\"[1-475]T$	SSF53756

","BeTs to 8 clades of COG0297COG name: Glycogen synthaseFunctional Class: GThe phylogenetic pattern of COG0297 is -m-k-qvCeb-h------in-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 37-119 are 35% similar to a (STARCH SYNTHASE III TRANSFERASE) protein domain (PD238840) which is seen in O49727_ARATH.Residues 126-356 are 58% similar to a (SYNTHASE STARCH GLYCOGEN TRANSFERASE) protein domain (PD187428) which is seen in Q9CHM9_LACLA.Residues 363-437 are 58% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD000172) which is seen in GLGA_BACSU.Residues 1-30 are 76% similar to a (STARCH SYNTHASE GLYCOGEN TRANSFERASE) protein domain (PD002219) which is seen in Q9MAC8_ARATH.Residues 1-117 are 33% similar to a (PROTEOME COMPLETE GLYCOGEN SYNTHASE) protein domain (PD294310) which is seen in O66935_AQUAE.Residues 409-474 are 40% similar to a (PROTEOME COMPLETE GLYCOGEN SYNTHASE) protein domain (PD406654) which is seen in Q9WZZ7_THEMA.Residues 1-61 are 41% similar to a (PROTEOME COMPLETE GLYCOGEN SYNTHASE) protein domain (PD208693) which is seen in Q9Z6V8_CHLPN.Residues 39-122 are 51% similar to a (GLYCOGEN SYNTHASE PROTEOME COMPLETE) protein domain (PD331879) which is seen in Q9CHM9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:13:25 2002","Wed Mar 13 16:20:42 2002","Thu Oct 17 15:13:25 2002","Wed Mar 13 16:20:42 2002","","Wed Mar 13 16:20:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1397 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 13 16:22:37 2002","","No significant hits to the NCBI PDB database.","SMU.1536c","","No significant hits to the Pfam 11.0 database","Wed Mar 13 16:20:42 2002","","","","Takata,H., Takaha,T., Okada,S., Takagi,M. and Imanaka,T.Characterization of a gene cluster for glycogen biosynthesis and aheterotetrameric ADP-glucose pyrophosphorylase from BacillusstearothermophilusJ. Bacteriol. 179 (15), 4689-4698 (1997)PubMed: 9244254","","Wed Mar 13 16:22:37 2002","1","","","SMU.1536c","" "SMu1398","1464773","1463640","1134","ATGAAGATTGATAAATATTCTGCAATTCTAGGAAGTGCTATCGGATTCCCAGAAATGGAAGGATTAACAGATACGCGTCCCTTGGCAAATCTGCCTTTTGATGGTAAATATCGCTTAATTGACTTTCAATTATCAAATTTAGCAAATGCTGGTATTCGAAGTGTTTATGGTATTTTCCGTGGACAAAATATTCGTTCTATTTTTGATCATATCAGAAGCGGTCGTGAATGGGGTCTTAATACACTCTTAAGTCATTATTTCCTAGGTTTCTATAATACACCAGAAGATAGTATTTATGCCGATAAGGATTATTATGATCAAATCTTGACTTATTTAAAACGTTCAGGTTCTGATCAAACCATTTACATGTCTTGTGATATTCTGTGTAATATTGACTTGCAGCAAGTGATTCATCTGCATAATGCTAATAAACGCAATATAACAGTTGTTTATAAAAAATTGCCAATCAATGCTATTTCTGCAGCTAATGACATTTTAGAAATTGATGAAACGGATACTGTTACGGGACGCCGTGATAGTCAGTCTGGTAATGAAACAGAAAAAATGTCTGCTGGTATCTATATTGTGAATACCTCTTGGTTGATTGAGCAGATGGAAAAAGAAAATCAAAAAGAAGAACCGATTAATCTTCGTTTCTTATTGCGTGATTTGACAGTAGCTGAGAAAGCTCTTGCTTTTGAATACACTGGTTATTTGGCTAATATTTCTTCTATCCAGTCTTATTACAATGCCAATATGGATATGCTGGAATCTCAAAAATTTTATTCCTTGCTTTATTCTAACCAAAAAGTTTATACTAAGGTCAAAAATGAAGAAGCGACCTATTTTGCAGTGGATTCGACTGTAAAAAATGCTCAGTTTGCTTCAGGAAGCATCATCAAAGGAACTGTAGATCATTCCATTATTTCGCGCAACTGCCATATTGCTAATCATTCTCGTGTTGTTAACAGTGTTGTTTTCCCTAAAGTAAGCATTGGTGATGGTGCAGTAGTAGAGAATGCTATTCTTGATAAAAATGTTAAGATTGCTCCTGGAGTGATCATTCGCGGTACGGGAGATAAACCTATTGTTATCGCAAAAGCAAGTGAAGTTGTTGAGGATATTATTCAATGA","6.00","-4.44","42323","MKIDKYSAILGSAIGFPEMEGLTDTRPLANLPFDGKYRLIDFQLSNLANAGIRSVYGIFRGQNIRSIFDHIRSGREWGLNTLLSHYFLGFYNTPEDSIYADKDYYDQILTYLKRSGSDQTIYMSCDILCNIDLQQVIHLHNANKRNITVVYKKLPINAISAANDILEIDETDTVTGRRDSQSGNETEKMSAGIYIVNTSWLIEQMEKENQKEEPINLRFLLRDLTVAEKALAFEYTGYLANISSIQSYYNANMDMLESQKFYSLLYSNQKVYTKVKNEEATYFAVDSTVKNAQFASGSIIKGTVDHSIISRNCHIANHSRVVNSVVFPKVSIGDGAVVENAILDKNVKIAPGVIIRGTGDKPIVIAKASEVVEDIIQ","1463655","For other 'glg' genes see SMu1396 (glgP); SMu1397 (glgA); SMu1399 (glgC); SMu1400 (glgB); SMu1422 (glg) and SMu1539 (glg3). ","glycogen biosynthesis protein","Cytoplasm, Membrane","Several matches in gapped BLAST to glycogen biosynthesis proteins: residues 1-375 are 62% similar to the enzyme in S.pneumoniae (gi|15900990|). Residues 4-369 are 28% similar to the protein from Geobacillus stearothermophilus (gi|2811061|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0854 (4e-31).","

InterPro
IPR001451
Repeat

Bacterial transferase hexapeptide repeat
PF00132	$\"[306-323]T$ $\"[340-357]T$	Hexapep

InterPro
IPR005835
Domain

Nucleotidyl transferase
PF00483	$\"[31-80]T$	NTP_transferase

InterPro
IPR011004
Domain

Trimeric LpxA-like
SSF51161	$\"[230-371]T$	Trimer_LpxA_like

InterPro
IPR011832
Family

Glucose-1-phosphate adenylyltransferase, GlgD subunit
PTHR22572:SF9	$\"[19-358]T$	GlgDAde_trans
TIGR02092	$\"[4-371]T$	glgD

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[19-309]T$	G3DSA:3.90.550.10
PTHR22572	$\"[19-358]T$	PTHR22572
SSF53448	$\"[19-273]T$	SSF53448

InterPro
IPR005835
Domain

Nucleotidyl transferase
PF00483	$\"[8-263]T$	NTP_transferase

InterPro
IPR005836
Family

ADP-glucose pyrophosphorylase
PS00808	$\"[13-32]T$	ADP_GLC_PYROPHOSPH_1
PS00809	$\"[100-108]?$	ADP_GLC_PYROPHOSPH_2
PS00810	$\"[191-201]T$	ADP_GLC_PYROPHOSPH_3

InterPro
IPR011831
Family

Glucose-1-phosphate adenylyltransferase
TIGR02091	$\"[7-362]T$	glgC: glucose-1-phosphate adenylyltransfera

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[8-297]T$	no description
PTHR22572	$\"[15-377]T$	SUGAR-1-PHOSPHATE GUANYL TRANSFERASE
PTHR22572:SF10	$\"[15-377]T$	GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE

","BeTs to 6 clades of COG0448COG name: ADP-glucose pyrophosphorylaseFunctional Class: GThe phylogenetic pattern of COG0448 is ------VceBrh------in-Number of proteins in this genome belonging to this COG is 2","***** IPB001825 (ADP-glucose pyrophosphorylase) with a combined E-value of 1.5e-66. IPB001825A 11-64 IPB001825C 96-119 IPB001825D 145-185 IPB001825E 188-207 IPB001825F 213-226 IPB001825G 243-257 IPB001825H 265-307 IPB001825I 310-344","Residues 1-265 are 23% similar to a (PROTEOME TRANSFERASE COMPLETE) protein domain (PD401152) which is seen in Q9CHN0_LACLA.Residues 322-362 are 63% similar to a (ADP-GLUCOSE TRANSFERASE PYROPHOSPHORYLASE) protein domain (PD000882) which is seen in Q9CHN1_LACLA.Residues 292-362 are 35% similar to a (PROTEOME TRANSFERASE COMPLETE) protein domain (PD255493) which is seen in Q9RTE1_DEIRA.Residues 7-162 are 77% similar to a (ADP-GLUCOSE TRANSFERASE PYROPHOSPHORYLASE) protein domain (PD349444) which is seen in Q9CHN1_LACLA.Residues 7-80 are 37% similar to a (TRANSFERASE COMPLETE PROTEOME BIOSYNTHESIS) protein domain (PD000318) which is seen in Q9RWF8_DEIRA.Residues 271-321 are 60% similar to a (TRANSFERASE NUCLEOTIDYLTRANSFERASE) protein domain (PD210493) which is seen in Q9CHN1_LACLA.Residues 165-266 are 62% similar to a (TRANSFERASE PYROPHOSPHORYLASE ADP-GLUCOSE) protein domain (PD001252) which is seen in Q9CHN1_LACLA.Residues 165-257 are 32% similar to a (TRANSFERASE GLUCOSE-1-PHOSPHATE) protein domain (PD000406) which is seen in Q9ZA42_STRVN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Oct 27 18:19:50 2002","Wed Mar 13 16:30:38 2002","Thu Oct 17 15:12:34 2002","Wed Mar 13 16:30:38 2002","Wed Mar 13 16:30:38 2002","Wed Mar 13 16:30:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1399 is paralogously related (blast p-value < 1e-3) to SMu1398, a predicted glycogen biosynthesis protein; SMu1330,a predicted glucose-1-phosphate thymidyltransferase; SMu1488,a predicted UDP-N-acetylglucosamine pyrophosphorylase and SMu0289, a predicted glucose-1-phosphate uridylyltransferase.","Wed Mar 13 16:36:09 2002","Wed Mar 13 16:30:38 2002","pdb|1G23|A Chain A, The Structural Basis Of The Catalytic Mecha... 78 2e-015pdb|1FXO|A Chain A, The Structural Basis Of The Catalytic Mecha... 77 3e-015","SMU.1538c","","Residues 8 to 263 (E-value = 8.7e-81) place SMu1399 in the NTP_transferase family which is described as Nucleotidyl transferase (PF00483)","Wed Mar 13 16:30:38 2002","","","","Takata,H., Takaha,T., Okada,S., Takagi,M. and Imanaka,T.Characterization of a gene cluster for glycogen biosynthesis and aheterotetrameric ADP-glucose pyrophosphorylase from BacillusstearothermophilusJ. Bacteriol. 179 (15), 4689-4698 (1997)PubMed: 9244254","","Wed Mar 13 16:47:09 2002","1","","","SMU.1538c","" "SMu1400","1467814","1465928","1887","ATGAATGAGAGAGAAGCACTCAGAACATTTGGAACTGGAGAAAACTTTCATGCACAACACTACTTTGGATTTCATGAAACTGAAAAAAATGGCGTAAAGGGTTATATTTTCAGGGTTTGGGCGCCAAATGCTGAGGATCTTCATCTTATTGGTGACTTTACTGGCTGGTTTGATAATCCCTTACAAATGGATAAAAATGAGGCAGGCGTTTGGGAAGTCTTTACGGATTTACCTAAGGAAGGCCATATATATAAATACCTTGTGAAGCGACAAGGTGGGCAAATTGTTGAAAAGATGGATCCATTTGCTATTTATTTGGAAGAGCGTCCGGGAACGGGTTCTCTCATCAGAACCATTCCTGAAAAGAAATGGAAAGATGGTCTTTGGTTGGGCCGCCGTAAACGCTGGGGATTCTTTAAAAGGCCAGTCAATATTTATGAAGTTCATGCGGGTTCTTGGAAGCAAAATGAAGATGGAAGTCCCTATAGCTTTGAACAATTAAAGGATGAATTGGTTCCTTACTTAGTAAAGATGAATTATACACATGTTGAATTCATGCCTTTGATGGCTCATCCTTTGGGCATGAGCTGGGGCTATCAATTGATGGGCTTCTTTGCCTTTGAGCACACCTATGGTACTCCAGAACAGTTTCAGGATTTTGTTGAAGCCTGCCATCTTAATAATATTGGTGTCATTGTTGACTGGGTGCCTGGTCACTTTACACAAAACGATGATGCTCTGGCTTATTTTGATGGGACACCGACCTTTGAGTATCAGGATCATGACCGTGCCCATAATTATCGTTGGGGAGCTCTTAATTTCGATTTGGGTAAAAATCAAGTGCAATCTTTCTTGATTTCTAGTGCTAAATTTTGGATAGATTTCTATCATATTGATGGTATTCGTGTTGATGCTGTCAGCAATATGCTCTATTTGGATTATGACGAAGGGCCTTGGCAGCCTAACATAGAAGGTAACAATCGCAATCTAGAAGGTTATTATTTTTTGCAGCGTTTAAATACAGTGCTCAAATTAGCTCATCCAGATGTAATGATGATTGCAGAAGAGTCAACAGCTACAACTAAGATTACAGGCAGGCGTGAAGAAGGTGGTCTGGGATTTGACTATAAATGGAATATGGGTTGGATGAATGATATTTTGAAATTCTATGAAGAAGATCCAATTTATCGCAAATACGATTTTAACCTTGTGACGTTTAGTTTTATGTATCTCTTTTCCGAAAATTTTATCTTACCATTTTCACATGATGAAGTTGTGCACGGCAAAAAGAGTCTGATGCATAAAATGTGGGGGGATCGTTATAATCAATTTGCTGGTCTGAGAAATTTATATACTTATCAAATCTGCCATCCTGGTAAAAAACTGCTTTTTATGGGAAGTGAATTTGGCCAATTCTTGGAATGGAAATATGACCATGCCCTTGAGTGGACTAATCTTGAGGAAGAGGACGGACTTAATCTTAAAATGCAAGATTTTACCAGCCAACTCAATCAATTTTATAAAGATCATAAGGTACTCTGGCAATTGGACACCAGTTATGATGGTTTAGAAATTATTGATGCTGATAATGTTGATGAAAGTGTCTTGTCTTTTATCAGAAAAAATGAGAAGGGAGATCTATTAGTCTGTGTCTTCAATATGGTTCCTGTGGAACGCAAAGGTTTTACAATAGGCGTTCCGGTTGCGGGTATATATGAAGAAGTATGGAATACTGAACTTGAGGAATTTGGTGGAGTTTGGAAAGAGCACAATATGACAGTCAAAACACAAAAAAATTTGTGGAAGGAATATGAAAATACGCTCAGCTTCACTTTGCCAGCCTTGGGTGCTAGTATTTGGAAAATAAAACGTCGTTTGAGAAAGTAA","5.50","-18.77","73960","MNEREALRTFGTGENFHAQHYFGFHETEKNGVKGYIFRVWAPNAEDLHLIGDFTGWFDNPLQMDKNEAGVWEVFTDLPKEGHIYKYLVKRQGGQIVEKMDPFAIYLEERPGTGSLIRTIPEKKWKDGLWLGRRKRWGFFKRPVNIYEVHAGSWKQNEDGSPYSFEQLKDELVPYLVKMNYTHVEFMPLMAHPLGMSWGYQLMGFFAFEHTYGTPEQFQDFVEACHLNNIGVIVDWVPGHFTQNDDALAYFDGTPTFEYQDHDRAHNYRWGALNFDLGKNQVQSFLISSAKFWIDFYHIDGIRVDAVSNMLYLDYDEGPWQPNIEGNNRNLEGYYFLQRLNTVLKLAHPDVMMIAEESTATTKITGRREEGGLGFDYKWNMGWMNDILKFYEEDPIYRKYDFNLVTFSFMYLFSENFILPFSHDEVVHGKKSLMHKMWGDRYNQFAGLRNLYTYQICHPGKKLLFMGSEFGQFLEWKYDHALEWTNLEEEDGLNLKMQDFTSQLNQFYKDHKVLWQLDTSYDGLEIIDADNVDESVLSFIRKNEKGDLLVCVFNMVPVERKGFTIGVPVAGIYEEVWNTELEEFGGVWKEHNMTVKTQKNLWKEYENTLSFTLPALGASIWKIKRRLRK","1465943","For other 'glg' genes see SMu1396 (glgP); SMu1397 (glgA); SMu1398 (glgD); SMu1399 (glgC); SMu1422 (glg) and SMu1539 (glg3). ","1,4-alpha-glucan branching enzyme","Cytoplasm","Several matches in gapped BLAST to 1,4-alpha-glucan branching enzyme: residues 1-627 are 77% similar to the enzyme in S.pneumoniae (gi|15903073|). Residues 10-619 are 44% similar to the protein from Geobacillus stearothermophilus (gi|232168|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0853 (0.0).","

InterPro
IPR004193
Domain

Glycoside hydrolase, family 13, N-terminal
PF02922	$\"[21-103]T$	Isoamylase_N

InterPro
IPR006047
Domain

Glycosyl hydrolase, family 13, catalytic region
PF00128	$\"[169-237]T$	Alpha-amylase

InterPro
IPR006048
Domain

Alpha-amylase, C-terminal all beta
PF02806	$\"[525-623]T$	Alpha-amylase_C

InterPro
IPR006407
Domain

1,4-alpha-glucan branching enzyme, core region
TIGR01515	$\"[7-621]T$	branching_enzym

InterPro
IPR013780
Domain

Glycosyl hydrolase, family 13, all-beta
G3DSA:2.60.40.1180	$\"[520-625]T$	Glyco_hydro_13_b

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[130-509]T$	Glyco_hydro_cat

InterPro
IPR013782
Family

1,4-alpha-glucan branching enzyme
PIRSF000463	$\"[1-625]T$	GlgB

InterPro
IPR013783
Domain

Immunoglobulin-like fold
G3DSA:2.60.40.10	$\"[9-119]T$	Ig-like_fold

noIPR
unintegrated

unintegrated
PTHR10357	$\"[100-620]T$	PTHR10357
PTHR10357:SF13	$\"[100-620]T$	PTHR10357:SF13
SSF51011	$\"[520-625]T$	SSF51011
SSF51445	$\"[79-513]T$	SSF51445

","BeTs to 7 clades of COG0296COG name: 1,4-alpha-glucan branching enzymeFunctional Class: GThe phylogenetic pattern of COG0296 is ----yq-cebRh------in-Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 348-619 are 47% similar to a (ENZYME BRANCHING GLYCOGEN 14-ALPHA-GLUCAN) protein domain (PD341301) which is seen in GLGB_BACST.Residues 34-191 are 28% similar to a (ENZYME BRANCHING GLYCOSYLTRANSFERASE) protein domain (PD376916) which is seen in Q9XGA6_SOLTU.Residues 250-340 are 52% similar to a (HYDROLASE ALPHA-AMYLASE GLYCOSIDASE PRECURSOR SIGNAL) protein domain (PD000173) which is seen in Q59242_BACST.Residues 10-197 are 38% similar to a (BRANCHING ENZYME GLYCOGEN 14-ALPHA-GLUCAN) protein domain (PD002139) which is seen in GLGB_BACST.Residues 233-340 are 52% similar to a (ENZYME BRANCHING GLYCOGEN TRANSFERASE) protein domain (PD000975) which is seen in Q9RTB7_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:12:09 2002","Wed Mar 13 16:51:29 2002","Thu Oct 17 15:12:09 2002","Wed Mar 13 16:51:29 2002","","Wed Mar 13 16:51:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1400 is paralogously related (blast p-value < 1e-3) to SMu1401, a predicted pullulanase.","Thu Mar 14 08:15:25 2002","","No significant hits to the NCBI PDB database.","SMU.1539c","","Residues 21 to 103 (E-value = 1.6e-22) place SMu1400 in the Isoamylase_N family which is described as Isoamylase N-terminal domain (PF02922)Residues 147 to 496 (E-value = 9.3e-06) place SMu1400 in the Alpha-amylase family which is described as Alpha amylase, catalytic domain (PF00128)","Wed Mar 13 16:51:29 2002","","","","Kiel,J.A., Boels,J.M., Beldman,G. and Venema,G.Molecular cloning and nucleotide sequence of the glycogen branching enzyme gene (glgB) from Bacillus stearothermophilus and expression in Escherichia coli and Bacillus subtilisMol. Gen. Genet. 230 (1-2), 136-144 (1991)PubMed: 1745226","","Wed Mar 13 16:51:29 2002","1","","","SMU.1539c","" "SMu1401","1470262","1468031","2232","ATGGGAAGGGATGCCTCTTTCTCACGTTTTGATAATTTTGGAATTGTTGGAAATCTCGTGTATGAGTCTGACACTTTTCAAAGTCAAGTCTATCTGATTGTCAAAAATGCTGACTGGTCCGTTAGAACGCCTGATTTCAGTATTAATTGCAATCCTGGTCTGTCTAAAAGCGAGGTTTGGATTGTTCAAGGGGATGATACGCTTTATTATTCATGGCAAGCAGCAGTTGCAAGCCATGCTTATAATCAACGTCAGCCGCATGCTTTTGATATGGCTGTCAATAGTAAGCGTTTTGATTATGAATGGGGTTTTCAAGGCTGGCTTGGTTTTTCTTATCAAGAAGATAAAACTGAATTTCGGCTTTGGGCACCAACTGCTAGACGGGTTGAATTAATTATTTACAGTTCAACTGGTGAGAAATCAAGTGTTCTCAAGGTTTTAAAAATGAAGCGCGGGGAAAACAGAACCCCTGATGATCATACAAAAAATACACATGGAGTCTGGAAGCGTACAGTCGAAGGTGACTTGAATTATCATGCTTATCGTTACCGTGTTTATTATCGCAGACGTATTTTTCGTGATACAAGAGATCCTTATTCTATTGCTGTGACGGCTGACGGGAAACGTTCAGTTGTTATTGCTGATACTGATTTAATACCGGAAGGTTTTAAAGTCAAACACAGGCAAGAGGCTAGTTGGCGTCTTAGCAATCCTAACCAAGCGGTGATAGCAGAGATGCATATCCGAGATTTTTCTAAATCTGAAACTTCAGGTGTCAGGCATGAAAATCGCGGCAAATTCTTAGGTGCTTTTGAAACAGGAACCAAAAATTTATATGGCGATCAAACAAGTTTTGATTATCTCAAGAGTTTAGGTATTAATTACGTGCAGCTGCAGCCTGTTTTTGATCATCACCAGACCTTCAATGAAGATGGCTCTTACGCCTATAATTGGGGTTATGATCCTGAAAACTACAATGTTCCAGAAGCTAGCTTTGCGAGCAATCCTCATGCACCGACCGCTCGTATTTTAGAATTAAAACAGCTCGTTCAGGCTTATCACGATGCAGGTATTGGTGTCATTATGGATGTGGTTTACAACCATACCTATTCTTCCACAGATTCTGCTTTTCAGCTGGCAGTGCCTGATTATTATTATCGTATGAATCATGATGGTTCCTTGCAAAATGGTTCGGGCTGTGGAAACGAGACCGCTAGTGAAAAAGAAATGTTTAGGAAATACATGATTGATTCCATTCTTTATTGGATTCAAGCCTATAATATTGATGGTTTTCGGTTTGATCTGATGGGGCTTCATGATGTTGAAACCATGAATGCTATTCGTCAGGCTGTTGATGCTATCGATCCAAATATCTTGCTTTATGGTGAAGGTTGGGATATGGGAATAGGTCTCATGCCAGAAGATAAGGCTAAAAAAGATAATGCTTATCAAATGCCGCGTATTGGTTTTTTCAATGACGATGTGAGAAATGCTATTAAGGGTGCTGAAGTTTACGGCGATTTCAAACGCGGTTTTGTATCAGGAGAGCCTACTGAGAATAAAATTGCCAAGGGCATGTTAGGCAGTGACGAATTAAGTTCTTATTTGGTACCGAACCAAGTACTCAATTATGTAGAGGCACATGACAATTATAACCTTAATGATCTGCTTATGGAATTACATCCTGAAGATGATAAGACAACTCATATTAAACGCGTTGAGCTGGCAAATAGTCTGGGGATTTTGATGCAGGGAATGGCCTTCATTGAATTAGGACAGGAATTTTTACGAACTAAGCTGTTTCCAACGGGTCCAGATGGGGAATTAACCCATGCTGATAAAGAACGCGCAATGAATAGTTATAATGCCCCCGATGAGGTCAATCAAATTGACTGGAATAATGTAACACTTTATAAGTCAACCGTTAATTTTGTTAAAGAATTAATTCGTTTAAAAACACAAGAAGAGGCTTTTTCTTATCAGACCTATGAGGACATCCGTAAGCATGTTTATGTTGAGTCAGCAGAATATGGATCTGGCTTAGTGATTGTCAGCATAAGTAGCCACGATAAAATTTTCAAATTAATTTTCAATGTTAGTGAAAAAAACGCTAAAATTGATATGACACAAGATGAAAAGTATGATATAATATTAACAAATATAAAACGCTTTCATAAATTGAGTGGACAACTTGAAAATTTGACAGCTACGGTCTTTGAATTAAAAAAATAA","5.70","-15.72","85318","MGRDASFSRFDNFGIVGNLVYESDTFQSQVYLIVKNADWSVRTPDFSINCNPGLSKSEVWIVQGDDTLYYSWQAAVASHAYNQRQPHAFDMAVNSKRFDYEWGFQGWLGFSYQEDKTEFRLWAPTARRVELIIYSSTGEKSSVLKVLKMKRGENRTPDDHTKNTHGVWKRTVEGDLNYHAYRYRVYYRRRIFRDTRDPYSIAVTADGKRSVVIADTDLIPEGFKVKHRQEASWRLSNPNQAVIAEMHIRDFSKSETSGVRHENRGKFLGAFETGTKNLYGDQTSFDYLKSLGINYVQLQPVFDHHQTFNEDGSYAYNWGYDPENYNVPEASFASNPHAPTARILELKQLVQAYHDAGIGVIMDVVYNHTYSSTDSAFQLAVPDYYYRMNHDGSLQNGSGCGNETASEKEMFRKYMIDSILYWIQAYNIDGFRFDLMGLHDVETMNAIRQAVDAIDPNILLYGEGWDMGIGLMPEDKAKKDNAYQMPRIGFFNDDVRNAIKGAEVYGDFKRGFVSGEPTENKIAKGMLGSDELSSYLVPNQVLNYVEAHDNYNLNDLLMELHPEDDKTTHIKRVELANSLGILMQGMAFIELGQEFLRTKLFPTGPDGELTHADKERAMNSYNAPDEVNQIDWNNVTLYKSTVNFVKELIRLKTQEEAFSYQTYEDIRKHVYVESAEYGSGLVIVSISSHDKIFKLIFNVSEKNAKIDMTQDEKYDIILTNIKRFHKLSGQLENLTATVFELKK","1468046","","pullulanase","Cytoplasm, Extracellular","Matches to glucan dextran glucosidase: residues 267-438 are 23% similar to a previously published enzyme in S.mutans (gi|153742|), (gi|544151|) and (gi|97985|). Numerous matches in gapped BLAST to pullulanase:residues 11-701 are 54% similar to the protein in S.pyogenes (gi|15903069|)Residues 93-743 are 35% similar to the enzyme from Geobacillus stearothermophilus (gi|228654|)The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0852 (0.0).","

InterPro
IPR004193
Domain

Glycoside hydrolase, family 13, N-terminal
PF02922	$\"[107-200]T$	Isoamylase_N

InterPro
IPR006047
Domain

Glycosyl hydrolase, family 13, catalytic region
PF00128	$\"[265-652]T$	Alpha-amylase

InterPro
IPR011840
Domain

Pullulanase, type I
TIGR02104	$\"[97-727]T$	pulA_typeI

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[227-658]T$	Glyco_hydro_cat

InterPro
IPR013783
Domain

Immunoglobulin-like fold
G3DSA:2.60.40.10	$\"[107-216]T$	Ig-like_fold

noIPR
unintegrated

unintegrated
PTHR10357	$\"[193-601]T$ $\"[617-717]T$	PTHR10357
PTHR10357:SF22	$\"[193-601]T$ $\"[617-717]T$	PTHR10357:SF22
SSF51445	$\"[160-658]T$	SSF51445

","BeTs to 6 clades of COG1523COG name: Pullulanase and related glycosidasesFunctional Class: GThe phylogenetic pattern of COG1523 is ------vCebrh------in-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 318-361 are 61% similar to a (HYDROLASE GLYCOGEN PROTEOME COMPLETE) protein domain (PD011435) which is seen in P71095_BACTN.Residues 316-361 are 52% similar to a (PULLULANASE DEXTRINASE STARCH PRECURSOR) protein domain (PD368771) which is seen in P93416_ORYSA.Residues 362-407 are 63% similar to a (PULLULANASE PROTEOME COMPLETE) protein domain (PD403899) which is seen in P71095_BACTN.Residues 43-238 are 23% similar to a (PULLULANASE HYDROLASE 6-GLUCANOHYDROLASE) protein domain (PD011262) which is seen in Q9K7U5_BACHD.Residues 112-304 are 32% similar to a (BRANCHING ENZYME GLYCOGEN 14-ALPHA-GLUCAN) protein domain (PD002139) which is seen in P71095_BACTN.Residues 362-434 are 51% similar to a (ENZYME BRANCHING GLYCOGEN TRANSFERASE) protein domain (PD000975) which is seen in PULA_THEMA.Residues 436-669 are 40% similar to a (PULLULANASE HYDROLASE 6-GLUCANOHYDROLASE) protein domain (PD007648) which is seen in O69008_THESP.Residues 242-303 are 45% similar to a (HYDROLASE GLYCOSIDASE GLYCOGEN ENZYME DEBRANCHING) protein domain (PD005949) which is seen in O34587_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 08:22:52 2002","Thu Mar 14 08:22:52 2002","Thu Oct 17 15:11:35 2002","Thu Mar 14 08:22:15 2002","","Thu Mar 14 08:22:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1401 is paralogously related (blast p-value < 1e-3) to SMu1400,a predicted 1,4-alpha-glucan branching enzyme; SMu0806,a predicted glucan 1,6-alpha- glucosidase; and SMu1851,a predicted dextran glucosidase (probable trehalose-6-phosphate hydrolase).","Thu Mar 14 08:26:33 2002","Thu Mar 14 08:22:15 2002","pdb|1BF2| Structure Of Pseudomonas Isoamylase 106 8e-024pdb|1SMA|A Chain A, Crystal Structure Of A Maltogenic Amylase >... 66 1e-011","SMU.1541c","","Residues 107 to 200 (E-value = 1.8e-09) place SMu1401 in the Isoamylase_N family which is described as Isoamylase N-terminal domain (PF02922)Residues 265 to 652 (E-value = 3.9e-08) place SMu1401 in the Alpha-amylase family which is described as Alpha amylase, catalytic domain (PF00128)","Thu Mar 14 08:22:15 2002","","","","Kuriki,T., Park,J.-H. and Imanaka,T.Characteristics of thermostable pullulanase from Bacillusstearothermophilus and the nucleotide sequence of the geneJ.Ferment.Bioeng. 69 (4), 204-210 (1990)","Mon Mar 18 10:59:52 2002","Thu Mar 14 08:24:00 2002","1","","","SMU.1541c","" "SMu1402","1471404","1470361","1044","ATGGTAAGAAAACAAAAACGTGCACGTTTAATTTACAATCCAACTTCAGGTCAAGAAATCATGAAGAAAAATGTAGCAGAAGTTTTAGATATCTTAGAGAGCTTTGGCTACGAAACGAGTGCCTTTCAGACTACGCCCAGAGCAGATTCTGCTAAAAATGAAGCTGCACGTGCCAGTCAAGCAGGGTTTGATTTAGTCATTGCTGCCGGAGGTGATGGCACTATCAATGAGGTTGTCAGCGGGATTGCACCTCTGAAAAGACGTCCTAAAGTGGCTATTATTCCAACGGGGACGACCAATGATTTTGCTCGTGCTCTTAAAATCCCCCGTGGCAATCCTGTTGAAGCAACTAAGCTCATTGGCAAGAACCAGACCATTCATATGGATATTGGTAGGGCTTATAATGACAAATATTTCATTAATATTGCCGCAGCAGGCAGTTTGACAGAATTGACCTATAGTGTGCCTAGCCAGCTAAAGACGATGTTTGGTTATCTTGCCTACTTAGTCAAGGGGGCGGAGCTCTTACCACGTGTTCGAAATGTCCCTGTCAAGGTCTTTTATGATCATGGCGTTTTTGAAGGTGAAGCTTCCATGATTTTTGTAGCTTTAACCAATTCTGTTGGAGGCTTTGAAACGATTGCTCCAGATGCTAAGTTGGATGATGGTAAGTTTACGCTCATCTTAGTTAAAACGGCTAATCTTTTTGAATTAACAGATCTTATTCGTCTTGTTTTAACAGGTGGGCGGCATATTAATCACAAAAAGATCGAGTATATTAAAACCAGTTACCTTAAAATTATTCCTCAAGGGAATCCTCCTAAGCGGATGATGATTAACCTTGATGGAGAGTACGGCGGTGATGCACCGATTGAATTGCGCAATTTAAAAAATCATATTGAATTCTTTGCTAATACAGATGAAATTTCAGATGATGCGATTACTCTTGATACAGAAGAACTGGTGCTAGAAGCAATTGCCCAGAAATTTGCGAGAGAAGCAGAAAGTCTGGATGAGATGGATAAAACAAAAGAGCAAGATTAG","6.40","-1.77","38300","MVRKQKRARLIYNPTSGQEIMKKNVAEVLDILESFGYETSAFQTTPRADSAKNEAARASQAGFDLVIAAGGDGTINEVVSGIAPLKRRPKVAIIPTGTTNDFARALKIPRGNPVEATKLIGKNQTIHMDIGRAYNDKYFINIAAAGSLTELTYSVPSQLKTMFGYLAYLVKGAELLPRVRNVPVKVFYDHGVFEGEASMIFVALTNSVGGFETIAPDAKLDDGKFTLILVKTANLFELTDLIRLVLTGGRHINHKKIEYIKTSYLKIIPQGNPPKRMMINLDGEYGGDAPIELRNLKNHIEFFANTDEISDDAITLDTEELVLEAIAQKFAREAESLDEMDKTKEQD","1470376","","conserved hypothetical protein, diacylglycerol kinase catalytic domain","Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypothetical protein and unknowns:residues 2-339 are 76% similar to conserved hypothetical protein from S.pyogenes (gi15674801) and residues 6-300 are 52% similar to hypothetical protein from B.subtilis (gi16077740) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0851 (1e-154).","

InterPro
IPR001206
Domain

Diacylglycerol kinase, catalytic region
PD005043	$\"[6-115]T$	DAGKc
PF00781	$\"[7-131]T$	DAGK_cat
SM00046	$\"[7-138]T$	DAGKc

InterPro
IPR005218
Family

Conserved hypothetical protein 147
TIGR00147	$\"[3-306]T$	CHP147

noIPR
unintegrated

unintegrated
PTHR12358	$\"[5-271]T$	PTHR12358
PTHR12358:SF4	$\"[5-271]T$	PTHR12358:SF4
SSF56796	$\"[6-96]T$	SSF56796

","BeTs to 5 clades of COG1597COG name: Uncharacterized proteins, BmrU familyFunctional Class: SThe phylogenetic pattern of COG1597 is ----Y-vceBR----------Number of proteins in this genome belonging to this COG is 1","***** IPB000756 (Diacylglycerol kinase accessory domain (presumed)) with a combined E-value of 1e-08. IPB000756D 65-79 IPB000756E 89-112","Residues 115-252 are 67% similar to a (COMPLETE PROTEOME ORF8 TRANSCRIPTIONAL) protein domain (PD266522) which is seen in Q9CIE3_LACLA.Residues 257-342 are 50% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD392555) which is seen in Q9CIE3_LACLA.Residues 7-106 are 74% similar to a (KINASE SPHINGOSINE COMPLETE PROTEOME) protein domain (PD005043) which is seen in Q9CIE3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 10:57:53 2002","Mon Sep 11 11:29:48 2006","Mon Sep 11 11:29:48 2006","Thu Mar 14 08:29:48 2002","Thu Mar 14 08:29:48 2002","Thu Mar 14 08:29:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1402 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 18 10:57:53 2002","","No significant hits to the NCBI PDB database.","SMU.1542c","","Residues 7 to 138 (E-value = 4.7e-18) place SMu1402 in the DAGK_cat family which is described as Diacylglycerol kinase catalytic domain (presumed) (PF00781)","Thu Mar 14 08:29:48 2002","24379930","","","","","","1","","","SMU.1542c","332" "SMu1403","1473375","1471417","1959","ATGAAAGAACGTATGAATGAGCTGGTTCAGCTTCTTAATCAATATGCCAGAGAATATTATACAAAAGATAATCCCAGTGTTTCAGATGCTGAGTACGATAAACTCTATCGTGAACTTGTAGAACTTGAAAAAGAATTTCCAGAGGATATTCTTCCTAATAGTCCGACGCATCGTGTGGGTGACCTTGTTTTAGATGGTTTTGAAAAGTATAGACATGAGTATCCTTTATTTTCTTTACAAGATGCTTTTTCTCGTGAAGAATTAGATGCTTTTGATAGGCGTATTAAAGCAGAATTTCCGCAGGCTGACTATTTAGCAGAATTGAAAATTGATGGTCTTTCTATTTCTCTAACCTATGTCAATGGCCGTTTACGAGTTGGGGCTACCAGAGGAGACGGGACAGTTGGTGAAAATATCACGGAGAACCTTAAGCGTGTGCGAGATATTCCACTGCATTTACCTGAAAATATTGATTTGACAGTACGTGGGGAATGCTATTTGCCTAAAGCTTCCTTTAAAACTATCAATGCTGAGCGTAGGGAAAATGGTGAGACTGAATTTGCGAATCCGCGAAATGCAGCGGCAGGCACTTTGCGTCAATTGGATACTAAGGTTGTGGCTAAACGAAAATTGGCGACCTTTATCTATCAAGAGGCTGGTCCGACAGCTGCCAGCAGTCAGGAAGCAGTACTAGAAAGTTTTGCCAAGCTCGGTTTTACAGTCAATCCTCGTCATATTATTTCCTCCTCAATGGATGCTATTTGGCAGTTTATTGAAGATGTTGCTAAGGAAAGGGCTGAACTTGCCTATGATATTGATGGCGTTGTTATCAAAGTGAACAGTTTGGCCTTACAAGAGGCGCTCGGTTTTACAGTTAAAGCACCCAGATGGGCCATTGCCTATAAATTTCCAGCTGAAGAAAAAACAGCAGAAATTTTATCGGTTGACTGGACAGTTGGTCGAACAGGGGTTGTGACACCAACAGCTAATTTAACACCTGTTCAGCTGGCAGGAACAACGGTCAGCCGAGCAACCTTACACAATGTTGACTATATTGCTGAAAAGGATATCCGAATTGGTGACATAGTTGTTGTTTATAAGGCTGGAGATATCATTCCGGCAGTTTTACATGTCGTTGAAAACAAACGTGACCAGCAAGTGCCGCTACCAATTCCAACAGTCTGTCCGTCCTGTCAGAGTGAACTGATCCATTTTGAGGATGAGGTGGCTCTTCGCTGTGTTAATCCACGCTGTCCAGCCCAATTAAAGGAGAAATTGATTCATTTTGCTAGTCGTGATGCTATGAATATTATAGGATTAGGTCCAGCTATTGTTGAAAAATTATTTACAGCAGAACTCATTTGCGATGTGGCTGATATCTATCAGTTGACTCCTGAGAACCTTATGCAGCTCGAAGGGATCAAGGAAAAATCAGCAACTAAGCTTTATAAGGCTATTCAGGCTTCCAAAGCCAATTCAGCCGAAAAACTTTTATTTGGATTGGGTATTCGTCATGTCGGCAGTAAGGCGAGCAGACTTCTTATGGAACGCTTTGAGAGTCTTGAGCAGTTAGCTGCTGCTGATTTTGATGATATTGCTGCTATTGATGGTTTGGGAATTGTTATTGCAGAGTCTTTAAAAACTTACTTTGCAACAGCAGGCGCACAGAAACTTTTGATAGAGTTAAAAACAGCAGGTTTGAACTTGACTTATCTCGGCAAAAAAACAGCAAGTGATGCTGCTTTAACTGGGATGACAATTGTTTTAACTGGTAAACTAGCAAACTTGACCCGCAGCCAAGCTAAAGAAAAACTACAAAGTCTTGGTGCTAATGTAGCTGGAAGTGTTTCTAAAAAAACCAGTCTGGTCATAGCGGGGAGTGATGCAGGTTCTAAATTAGAAAAGGCTAAAACTTTAGGAATTGAAATTAAGGATGAAGCTTGGCTAGAAAGTTTGTGA","5.50","-10.03","71834","MKERMNELVQLLNQYAREYYTKDNPSVSDAEYDKLYRELVELEKEFPEDILPNSPTHRVGDLVLDGFEKYRHEYPLFSLQDAFSREELDAFDRRIKAEFPQADYLAELKIDGLSISLTYVNGRLRVGATRGDGTVGENITENLKRVRDIPLHLPENIDLTVRGECYLPKASFKTINAERRENGETEFANPRNAAAGTLRQLDTKVVAKRKLATFIYQEAGPTAASSQEAVLESFAKLGFTVNPRHIISSSMDAIWQFIEDVAKERAELAYDIDGVVIKVNSLALQEALGFTVKAPRWAIAYKFPAEEKTAEILSVDWTVGRTGVVTPTANLTPVQLAGTTVSRATLHNVDYIAEKDIRIGDIVVVYKAGDIIPAVLHVVENKRDQQVPLPIPTVCPSCQSELIHFEDEVALRCVNPRCPAQLKEKLIHFASRDAMNIIGLGPAIVEKLFTAELICDVADIYQLTPENLMQLEGIKEKSATKLYKAIQASKANSAEKLLFGLGIRHVGSKASRLLMERFESLEQLAAADFDDIAAIDGLGIVIAESLKTYFATAGAQKLLIELKTAGLNLTYLGKKTASDAALTGMTIVLTGKLANLTRSQAKEKLQSLGANVAGSVSKKTSLVIAGSDAGSKLEKAKTLGIEIKDEAWLESL","1471432","","DNA ligase","Cytoplasm","Several matches in gapped BLAST to DNA ligase: residues 1-652 are 69% similar to the enzyme in S.pneumoniae (gi15903068). Residues 1-646 are 62% similar to the protein from Lactococcus lactis (gi15672401).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0850 (0.0).","

InterPro
IPR001357
Domain

BRCT
PF00533	$\"[577-652]T$	BRCT
SM00292	$\"[579-652]T$	BRCT
PS50172	$\"[577-652]T$	BRCT

InterPro
IPR001679
Family

NAD-dependent DNA ligase
TIGR00575	$\"[8-649]T$	dnlj
PS01055	$\"[109-138]T$	DNA_LIGASE_N1
PS01056	$\"[319-334]T$	DNA_LIGASE_N2

InterPro
IPR003583
Domain

Helix-hairpin-helix DNA-binding, class 1
SM00278	$\"[432-451]T$ $\"[466-485]T$ $\"[530-549]T$	HhH1

InterPro
IPR004149
Domain

Zinc-finger, NAD-dependent DNA ligase C4-type
PF03119	$\"[393-420]T$	DNA_ligase_ZBD

InterPro
IPR004150
Domain

NAD-dependent DNA ligase, OB-fold
PD003944	$\"[305-379]T$	DNAligase
PF03120	$\"[308-389]T$	DNA_ligase_OB

InterPro
IPR010994
Domain

RuvA domain 2-like
SSF47781	$\"[390-572]T$	RuvA_2_like

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[307-379]T$	OB_NA_bd_sub

InterPro
IPR013839
Domain

NAD-dependent DNA ligase, adenylation
PF01653	$\"[1-306]T$	DNA_ligase_aden

InterPro
IPR013840
Domain

NAD-dependent DNA ligase, N-terminal
SM00532	$\"[2-434]T$	LIGANc

noIPR
unintegrated

unintegrated
G3DSA:1.10.150.20	$\"[421-489]T$ $\"[490-572]T$	G3DSA:1.10.150.20
G3DSA:1.10.287.610	$\"[1-58]T$	G3DSA:1.10.287.610
G3DSA:3.30.470.30	$\"[113-240]T$	G3DSA:3.30.470.30
G3DSA:3.40.50.10190	$\"[575-652]T$	G3DSA:3.40.50.10190
PIRSF001604	$\"[2-652]T$	LigA
PTHR11107	$\"[1-652]T$	PTHR11107
PTHR11107:SF5	$\"[1-652]T$	PTHR11107:SF5
SSF50249	$\"[305-390]T$	Nucleic_acid_OB
SSF52113	$\"[575-651]T$	SSF52113
SSF56091	$\"[1-306]T$	SSF56091

","BeTs to 12 clades of COG0272COG name: NAD-dependent DNA ligase (contains BRCT domain type II)Functional Class: LThe phylogenetic pattern of COG0272 is -----qvcEbrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001679 (NAD-dependent DNA ligase) with a combined E-value of 7.6e-213. IPB001679A 15-40 IPB001679B 54-90 IPB001679C 104-150 IPB001679D 187-211 IPB001679E 265-315 IPB001679F 334-376 IPB001679G 391-400 IPB001679H 418-460 IPB001679I 481-522 IPB001679J 584-594 IPB001679K 609-641","Residues 582-646 are 70% similar to a (DNA LIGASE NAD REPLICATION) protein domain (PD002763) which is seen in Q9CIE4_LACLA.Residues 435-507 are 46% similar to a (LIGASE DNA NAD SYNTHASE) protein domain (PD413475) which is seen in Q9F150_AQUPY.Residues 437-520 are 36% similar to a (DNA NAD LIGASE REPAIR) protein domain (PD399181) which is seen in DNLJ_ZYMMO.Residues 435-507 are 60% similar to a (DNA LIGASE NAD SYNTHASE) protein domain (PD001207) which is seen in Q9CIE4_LACLA.Residues 1-434 are 66% similar to a (DNA LIGASE NAD POLYDEOXYRIBONUCLEOTIDE) protein domain (PD003944) which is seen in Q9CIE4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 08:35:14 2002","Thu Mar 14 08:34:07 2002","Tue Aug 1 12:06:04 2006","Thu Mar 14 08:34:07 2002","Thu Mar 14 08:34:07 2002","Thu Mar 14 08:34:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1403 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 08:35:14 2002","Tue Aug 1 12:06:04 2006","pdb1DGSA Chain A, Crystal Structure Of Nad+-Dependent Dna Lig... 437 2e-123pdb1B04B Chain B, Structure Of The Adenylation Domain Of An N... 306 6e-084","SMU.1543c","","Residues 1 to 306 (E-value = 1.9e-149) place SMu1403 in the DNA_ligase_aden family which is described as NAD-dependent DNA ligase adenylation domain (PF01653)Residues 308 to 390 (E-value = 4.8e-43) place SMu1403 in the DNA_ligase_OB family which is described as NAD-dependent DNA ligase OB-fold domain (PF03120)Residues 393 to 420 (E-value = 5.6e-13) place SMu1403 in the DNA_ligase_ZBD family which is described as NAD-dependent DNA ligase C4 zinc finger domain (PF03119)Residues 577 to 652 (E-value = 2.3e-12) place SMu1403 in the BRCT family which is described as BRCA1 C Terminus (BRCT) domain (PF00533)","Tue Aug 1 12:06:04 2006","","","","Brannigan,J.A., Ashford,S.R., Doherty,A.J., Timson,D.J. andWigley,D.B.Nucleotide sequence, heterologous expression and novel purification of DNA ligase from Bacillus stearothermophilus(1)Biochim. Biophys. Acta 1432 (2), 413-418 (1999)PubMed: 10407164","","Thu Mar 14 08:35:14 2002","1","","","SMU.1543c","94" "SMu1404","1474097","1473585","513","ATGAAACAACTAACTGTTCGTGATTTAGCCCATATCGCCATTGTGGCGGCCTTATATGTCGCCTTGACTGCGACTCCGCCGTTAAATGCCATCTCTTATGGTGGTATACAATTTCGGCTTTCAGAAATGCTTAATTTTTTAGCTTTCTATAATCCTAAATACATCATTGCTGTTACTCTAGGCTGTATGATTGCCAATACTTTTGGGACTATTGGTCTTCTTGATGTCTTTGTCGGCGGTGGTTCAACCTTAGTTTTTGTAACATTAGGCCTGATCCTTTTTTCTAAGTATAAAAAGGAATACATTTTTAATGGCCTCTTTAATAAGGCCTTCTTTTACTTTTCTGTGTTTTACGCTATATTTATGGTAACGATAGCAGCGGAAATTTCTCTTGTTCTCCAAACGCCATTTTTACTGACTTGGATAACTGTAGCAGTAGGAGAATTGATTTCCTCTCTTTTTGGAGCTCTTGTGATTGATAAATTGGCCCAATATATAGATTTTACAAGATAA","9.20","2.17","18784","MKQLTVRDLAHIAIVAALYVALTATPPLNAISYGGIQFRLSEMLNFLAFYNPKYIIAVTLGCMIANTFGTIGLLDVFVGGGSTLVFVTLGLILFSKYKKEYIFNGLFNKAFFYFSVFYAIFMVTIAAEISLVLQTPFLLTWITVAVGELISSLFGALVIDKLAQYIDFTR","1473600","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical protein and citrulline cluster-linked gene: residues 1-168 are 68% similar to gi|15674799| from S.pyogenes and residues 1-170 are 58% similar to gi|15672777| from Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0849 (7e-61).","

InterPro
IPR010387
Family

Protein of unknown function DUF988
PF06177	$\"[5-170]T$	DUF988

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-169 are 58% similar to a (& PROTEOME BIOSYNTHETIC COMPLETE) protein domain (PD097644) which is seen in Q9CHD7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:32:18 2002","Thu Mar 14 08:38:27 2002","Thu Mar 14 08:38:27 2002","Thu Mar 14 08:38:27 2002","","Thu Mar 14 08:38:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1404 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:32:18 2002","","No significant hits to the NCBI PDB database.","SMU.1545c","","Residues 5 to 170 (E-value = 3.9e-104) place SMu1404 in the DUF988 family which is described as Protein of unknown function (DUF988) (PF06177)","Thu Mar 14 08:38:27 2002","24379932","","","","","","1","","","SMU.1545c","789" "SMu1405","1474220","1474678","459","ATGAAAAGATTACTACGCAATGAAACCCTAAAAAAGATTATTACCCATGAAACTTCCAAATATATTTTTTTCGGCATTCTGACTACCTTTGTCTATTTTCTAACACGGACGCCGCTCTTTTTCATTACTAAAGAAGCTACTCTTTCAGCAGTCATTGCTAATGTCACTTCTATTACCTTTGCCTTCTTTACCAATGATTATTTTGTTTTTAACCAAAAACGTCAAGGCTGGCTGAAACGTTTTATTCAATTTTTCATCGCCCGTCTATCAACCTTAGCACTTGATTTGCTGCTGGCCTTTTTACTTGTTGACAAGTTTCCGGGTATTATCGGCCGTTTTGTCAGAAACAATCATGATATGATTAATTTTATTGAAACCATTATTTCACAGTTTTTGATTATGGCAACCAATTATATCATCAGTAAATTCTTTATTTTTAAAAATAAAAAAGAGAGCTAA","11.00","11.46","17965","MKRLLRNETLKKIITHETSKYIFFGILTTFVYFLTRTPLFFITKEATLSAVIANVTSITFAFFTNDYFVFNQKRQGWLKRFIQFFIARLSTLALDLLLAFLLVDKFPGIIGRFVRNNHDMINFIETIISQFLIMATNYIISKFFIFKNKKES","1474687","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to unknowns and different kinds of proteins:residues 10-138 are 38% similar to GtrA family protein from S.pneumoniae (gi|15900883|) and are 28% similar to unknown from Lactococcus lactis (gi|15672596|) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0848 (1e-25).","

InterPro
IPR007267
Family

GtrA-like protein
PF04138	$\"[20-146]T$	GtrA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 21-138 are 28% similar to a (PROTEOME COMPLETE EPR-GALK TRANSMEMBRANE) protein domain (PD294801) which is seen in Q9CHV4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:31:41 2002","Thu Mar 14 08:43:32 2002","Thu Mar 14 08:43:32 2002","Thu Mar 14 08:43:32 2002","","Thu Mar 14 08:43:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1405 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:31:41 2002","","No significant hits to the NCBI PDB database.","SMU.1546","","Residues 20 to 146 (E-value = 2.6e-15) place SMu1405 in the GtrA family which is described as GtrA-like protein (PF04138)","Thu Mar 14 08:43:32 2002","24379933","","","","","","1","","","SMU.1546","920" "SMu1406","1475357","1474761","597","ATGAAATTACTAGTTGCTGAAGATCAATCCATGCTGCGAGATGCGCTCTGCCAATTACTGCTTATGGAAGATGATGTTGAAGAGATTTATCAGGCAGCTGATGGTCAAGAGGCAATTGAGCTACTTGGTAAGCAAACAGTTGATGTTGCTATTTTAGATATTGAAATGCCAATCAAAACAGGTTTGGATGTTTTAGAGTGGATTCGTCAGCACCAAGATACTAAGGTCATTATTGTGACAACGTTCAAACGTTCTGGTTATTTCAAACGCGCTTTAGCAGCCCATGTTGATGCTTATGTACTTAAGGATCGCTCTGCCAGTGAATTAATGGCAACCATTTATACTGTCCTTTCAGGTCAGCGGGAGTACTCACCAGAGTTAGTTGAAGAGGTAACCTTTGACAGCAATCCGCTTAGTGAACGGGAACAAGAAGTTTTACAATTGGTTGCTAAAGGAGCCTCCAATCAAACAATAGCAGAGCAGCTTTTTTTGTCCAATGGAACTATCCGCAACTATATGACAGCTATTTTTAACAAGCTTAACGCCAACAATCGAACAGATGCAGTCCGTATTGCGCGTGAGAATGGTTGGTTCTAA","4.50","-10.55","22401","MKLLVAEDQSMLRDALCQLLLMEDDVEEIYQAADGQEAIELLGKQTVDVAILDIEMPIKTGLDVLEWIRQHQDTKVIIVTTFKRSGYFKRALAAHVDAYVLKDRSASELMATIYTVLSGQREYSPELVEEVTFDSNPLSEREQEVLQLVAKGASNQTIAEQLFLSNGTIRNYMTAIFNKLNANNRTDAVRIARENGWF","1474776","","response regulator","Cytoplasm","Matches in gapped BLAST to responder protein:residues 2-130 are 25% similar to the previously published protein in S.mutans (gi|14600271|). Several matches to DNA-binding response regulator: residues 1-197 are 64% similar to the protein in S.pneumoniae (gi|15903856|). Residues 1-198 are 45% similar to the protein from B.subtilis (gi|16078980|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0322 (3e-22).","

InterPro
IPR000792
Domain

Bacterial regulatory protein, LuxR
PD000307	$\"[137-192]T$	HTH_LuxR
PR00038	$\"[138-152]T$ $\"[152-168]T$ $\"[168-180]T$	HTHLUXR
PF00196	$\"[135-192]T$	GerE
SM00421	$\"[135-192]T$	HTH_LUXR
PS00622	$\"[152-179]T$	HTH_LUXR_1
PS50043	$\"[131-196]T$	HTH_LUXR_2

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[1-117]T$	Response_reg
PF00072	$\"[1-114]T$	Response_reg
SM00448	$\"[1-113]T$	REC
PS50110	$\"[2-117]T$	RESPONSE_REGULATORY

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-125]T$	CheY_like

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[136-198]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[1-126]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[2-122]T$	PTHR23283
PTHR23283:SF47	$\"[2-122]T$	PTHR23283:SF47
SSF46894	$\"[116-198]T$	SSF46894

","BeTs to 4 clades of COG2197COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG2197 is -------CEBRh---------Number of proteins in this genome belonging to this COG is 4","***** IPB000792 (Bacterial regulatory protein, LuxR family) with a combined E-value of 1.5e-20. IPB000792 138-184***** IPB000673 (CheB methylesterase) with a combined E-value of 4.5e-11. IPB000673B 20-73***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 3.9e-06. IPB001867A 48-61 IPB001867B 75-119 IPB001867C 136-167","Residues 1-117 are 66% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in Q9S1I7_STRPN.Residues 137-194 are 58% similar to a (DNA-BINDING TRANSCRIPTION REGULATION REGULATOR) protein domain (PD000307) which is seen in Q9S1I7_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 08:51:11 2002","Tue Jan 8 12:00:46 2002","Thu Oct 17 15:08:54 2002","Thu Mar 14 08:50:08 2002","Tue Jan 8 12:00:46 2002","Tue Jan 8 12:00:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1406 is paralogously related (blast p-value < 1e-3) to SMu0441, SMu1782, SMu0841, SMu0947, SMu1032, SMu1379, SMu0237, SMu1048, SMu1748, SMu0601, and SMu1653, all predicted response regulators. ","Mon Mar 18 10:56:06 2002","Tue Jan 8 12:00:46 2002","pdb|1A04|A Chain A, The Structure Of The NitrateNITRITE RESPON... 90 1e-019","SMU.1547c","","Residues 1 to 121 (E-value = 1.5e-24) place SMu1406 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 135 to 192 (E-value = 4.3e-24) place SMu1406 in the GerE family which is described as Bacterial regulatory proteins, luxR family (PF00196)","Tue Jan 8 12:00:46 2002","24379934","","","Bhagwat SP, Nary J, Burne RA. Effects of mutating putative two-component systems on biofilm formation byStreptococcus mutans UA159. FEMS Microbiol Lett. 2001 Dec 18;205(2):225-30. PMID: 11750807","","Mon Mar 18 10:55:37 2002","1","","","SMU.1547c","757" "SMu1407","1476364","1475354","1011","ATGTGGACTTTAATTTTAACCGCTGGTTTTACAGTTGCCTATCTGCTTTTAGTTCGGCTGAAGGCCAGCTATCATAGGGTAATTGCGGTCTTATGGTTTTACACACTGGCTTACATTGCTTTTATGACTCTAGCTTATGAAGGGGCTATGATGTGGTTTCTTTTTTATCATGTCAATCTATTGGTTTGGCGGTTTGGAGACAGCTACCGGTCTTACCGCTTTTTATCCTTTTCTCTGGTCACTTTTTTTCTGGGGATTAATGGCATTATTTATGGGATTGTTCATAGGAACAGTATTGCTGTCTTTTTGATGTCCATCACACTTCCAATTTTTGTATTTGGCATGTACTATTTCCAAAATCATCTACGTTTGCAAGAAAAAATGGAAGCAGAGATTGTTGAGCAAAACCGCACCATCAATATCCTATCTGCTGAAAATGAGCGCAATCGGATCGGCCGTGATTTACATGACACATTGGGGCATACCTTTGCCATGATGAGTCTCAAGACGGAGCTGGCGCTTAAGCAAATGAAAAAGGGTCGGTACGAAGCCGTGCAAAAGCAACTAGAAGAGCTCAATCAAATCAGTCATGATTCCATGCATGAGGTGCGCGAACTTGTCAATCATCTCAAATATCGGACAGTGTCGGAGGAGCTGACTGAAATGGAGCGTCTCTTTGGTTTATCTGATATCAGTCTATCTGTTGACAATCAGTTGGACTTGGACAGCTTATCCCCTGTTACTCAGTCTACTATGACCATGGTTCTGCGGGAGCTGGCTAATAATGTCATCAAGCACAGCCAGGCTGATGACTGTCAGATTACGATCAAACGTGGGGAGGAGATTGAAGTAACTGTTGAGGATAATGGTGTTGGATTTGATGAACTGACAGGTCAGGAATTGCACTCTATTCGTGAACGGCTTGGTCTGGTCAATGGAGAAGTTGAAGTTACCTCTTCCAACAATCCAACAGTCGTCACTATTTACCTAAATGAAGGAGGACGTCAATGA","4.80","-13.10","26650","MWTLILTAGFTVAYLLLVRLKASYHRVIAVLWFYTLAYIAFMTLAYEGAMMWFLFYHVNLLVWRFGDSYRSYRFLSFSLVTFFLGINGIIYGIVHRNSIAVFLMSITLPIFVFGMYYFQNHLRLQEKMEAEIVEQNRTINILSAENERNRIGRDLHDTLGHTFAMMSLKTELALKQMKKGRYEAVQKQLEELNQISHDSMHEVRELVNHLKYRTVSEELTEMERLFGLSDISLSVDNQLDLDSLSPVTQSTMTMVLRELANNVIKHSQADDCQITIKRGEEIEVTVEDNGVGFDELTGQELHSIRERLGLVNGEVEVTSSNNPTVVTIYLNEGGRQ","1475369","","sensor histidine kinase","Cytoplasm, Membrane","Matches in gapped BLAST to sensor histidine kinase sequences . Residues 8-227 are 44% similar to gi15901824 from S.pneumoniae. Residues 1-225 are 33% similar to gi6759481 from B.cereus. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0310 (2e-68).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
PF02518	$\"[144-230]T$	HATPase_c
SM00387	$\"[144-231]T$	HATPase_c

InterPro
IPR006052
Family

Tumor Necrosis Factor
PS00251	$\"[5-21]?$	TNF_1

InterPro
IPR011712
Domain

Histidine kinase, dimerisation and phosphoacceptor region
PF07730	$\"[44-113]T$	HisKA_3

","BeTs to 7 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 23-130 are 50% similar to a (KINASE SENSOR TWO-COMPONENT PROTEOME COMPLETE SENSORY) protein domain (PD002447) which is seen in Q9S1I8_STRPN.Residues 153-216 are 36% similar to a (KINASE COMPLETE PROTEOME HISTIDINE) protein domain (PD088883) which is seen in Q9F5X3_BACLI.Residues 146-213 are 39% similar to a (KINASE SENSOR COMPLETE PROTEOME SENSORY TRANSDUCTION) protein domain (PD005700) which is seen in Q9RZE0_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:07:55 2002","Mon Jul 24 17:46:21 2006","Mon Jul 24 17:46:21 2006","Thu Mar 14 08:59:18 2002","","Tue Jan 8 12:01:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1407 is paralogously related (blast p-value < 1e-3) to SMu0440, and SMu1783 both predicted histidine kinases.","Thu Mar 14 08:59:18 2002","","No significant hits to the NCBI PDB database.","SMU.1548c","","Residues 144 to 230 (E-value = 7.2e-11) place SMu1407 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Tue Jan 8 12:01:50 2002","24379935","","","Grebe TW, Stock JB. The histidine protein kinase superfamily. Adv Microb Physiol. 1999;41:139-227. Review. PMID: 10500846 Alex LA, Simon MI. Protein histidine kinases and signal transduction in prokaryotes andeukaryotes. Trends Genet. 1994 Apr;10(4):133-8. Review. PMID: 8029829","","Thu Mar 14 08:59:18 2002","1","","","SMU.1548c","636" "SMu1409","1477190","1476453","738","ATGAAAGCATTATTAAAAGTTGAGTGGATTAAGACCTGGAGGACTTGGCCCATGTTCATCATGGCGGTTGGGATGCCAGTTGGTTTCTTTCTTATTTATTCAGGAATGAAGATGTATGACACAACACAAGGGCAGACAGATTTTATCAGATCATTTATGATTACTATGACCGCCTTTTCTATGTCGAGTTTTGGAATCTTTTCTTTCCCTTATATGCTTAAGGAAGACCAAACTAATCATTGGTTAAGCTATCTCGAACATTCTAGGATTTCCATTTATAAATATTATCTGTCAAAAATTTTTCGAGTTTTGCTGAATTTTTTAGTTTCTATTATTGTGACTTTTATGATTGGTGCTTTTGTTAGGCATGTGGAAATGACACCGATTCGCTGGATAGGAACAAGTTTACTGTTATTAATGGCTAGCTTAGTCTTTCTAGCTTTAGGGCTTTTGATTGAACGGATTAAATCCGAACAAATCATGTCTATTGTAGGAAATATTGCTTTTTTGGGTTTAGCCATTCTAGGGGGCTCTTGGATGCCTATTACTATGTTTCCAGACTGGGTACAGTCTATCTCTAAAGTTTCTCCCATTTATCACGTTAACCAATTAGCGGTCAATTTTGCTCAAAAAGGTCAGCTGACATGGAATTCCTTGTTTATTACACTGGCTTATGCCATAATAGTAGCAGGGCTTGCCCTATTCATTAAACAAAAACAAGAGGTTGAAAGTGTTTAG","10.50","7.95","28124","MKALLKVEWIKTWRTWPMFIMAVGMPVGFFLIYSGMKMYDTTQGQTDFIRSFMITMTAFSMSSFGIFSFPYMLKEDQTNHWLSYLEHSRISIYKYYLSKIFRVLLNFLVSIIVTFMIGAFVRHVEMTPIRWIGTSLLLLMASLVFLALGLLIERIKSEQIMSIVGNIAFLGLAILGGSWMPITMFPDWVQSISKVSPIYHVNQLAVNFAQKGQLTWNSLFITLAYAIIVAGLALFIKQKQEVESV","1476468","For other components see SMu1410 (NBD1).","ABC transporter, membrane spanning permease","Membrane, Cytoplasm","This is a potential ABC transporter, membrane spanning permeaseLimited matches in gapped BLAST to conserved hypothetical protein: residues 3-241 are 38% similar to gi15903858 from S.pneumoniae and residues 17-231 are 23% similar to gi15807680 from Deinococcus radiodurans.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0309 (9e-47).","

InterPro
IPR013525
Domain

ABC-2 type transporter
PF01061	$\"[2-210]T$	ABC2_membrane

","BeTs to 5 clades of COG0842COG name: Predicted integral membrane proteinFunctional Class: SThe phylogenetic pattern of COG0842 is A-TK--VcEBR-UJ-------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 17-193 are 22% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD415813) which is seen in Q9RZE1_DEIRA.Residues 6-228 are 26% similar to a (ABC TRANSPORTER TRANSMEMBRANE INTEGRAL) protein domain (PD354354) which is seen in Q9L4F5_BACCE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:15:13 2002","Mon Jul 3 16:59:57 2006","Mon Jul 3 16:59:57 2006","Thu Mar 14 09:05:26 2002","","Thu Mar 14 09:05:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1409 is paralogously related (blast p-value < 1e-3) to SMu0391,a predicted ABC transporter, CylB-like; and SMu0215, a predicted ABC transporter element.","Thu Mar 14 09:05:26 2002","","No significant hits to the NCBI PDB database.","SMU.1550c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 09:05:26 2002","24379936","","","","","","1","","","SMU.1550c","755" "SMu1410","1478068","1477187","882","ATGGCGAACACTGTTATAAGCGTTTCAAATTTATCCAAACAATTTAAGGCGAAAAAAGTTTTGAGAGACATTTCTTTTGAGGTTAATGAGGGTGACTGTATAGCGCTGATTGGACCAAATGGTGCAGGGAAGACAACCCTTATGTCTTGTATGTTAGGAGACATAAAGACTAGTTCAGGTCAAGTGCTTTTTAAAGGACAAAAAAATAAGCCCAAAGCTCAGGTAGCAGTTCTCCTACAGGAAAATACAATCCCTTCTGTCTTAAAAGTTAAGGAATTGATTGCATTCTTCAGGGAAATTGCAGATGATTCATTGACTGAAGAAGAAATTAGGCAATTATTGCAGTTTTCAGATCAGCAGTATGAGCAACTGGCTGGGAAATTATCTGGCGGTCAGCGTCGTCTCTTGGCTTTTATCCTTTGTCTGATTGGAAAACCTAAGGTTCTCTTTTTAGACGAGCCAACGGCAGGTATGGATACTTCCACACGGCAACGTTTCTGGGAGATTGTTCATGATTTGAAAGAAAATGGAACGACCATTCTCTATTCGTCTCATTATATTGAAGAAGTGGAGCATACAGCGGATCGCATTTTGGTCTTGCACCAAGGACAACTGATTCGGGATACGACCCCATTTGCCATGCGCAGTGAGGATAGAGAAAAACAAGTAACCTTATCTATTACTTATGCTCAGCTAGTTCATAGTCTTGATAAGGTCTACGACATAGAAGAAAAACGGGATACGGTAACCTTTATGACCAAGGATTTGGAACAAATATGGTCTATATTGCAGAAACAAGGTTGCAGTATTTCAGAGATTGAGATTCAAAATAAGACTCTATTAAATACCCTGTTTGATTCGACAAAAGGAGAAGAAGCATGA","5.60","-4.96","33061","MANTVISVSNLSKQFKAKKVLRDISFEVNEGDCIALIGPNGAGKTTLMSCMLGDIKTSSGQVLFKGQKNKPKAQVAVLLQENTIPSVLKVKELIAFFREIADDSLTEEEIRQLLQFSDQQYEQLAGKLSGGQRRLLAFILCLIGKPKVLFLDEPTAGMDTSTRQRFWEIVHDLKENGTTILYSSHYIEEVEHTADRILVLHQGQLIRDTTPFAMRSEDREKQVTLSITYAQLVHSLDKVYDIEEKRDTVTFMTKDLEQIWSILQKQGCSISEIEIQNKTLLNTLFDSTKGEEA","1477202","For other components see SMu1409 (MSD1).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Matches weakly in gapped BLAST to ABC transporter MutF: residues 1-289 are 26% similar to the previously published protein in S.mutans (gi|4322367|),(gi|9802352|).Residues 4-289 are 58% similar to the ABC transporter ATP binding protein from S.pneumoniae (gi|15903859|).Residues 1-280 are 34% similar to gi|7445618| from B.subtilis . The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0308 (5e-84).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[128-170]T$	ABC_transporter
PF00005	$\"[31-203]T$	ABC_tran
PS00211	$\"[128-142]?$	ABC_TRANSPORTER_1
PS50893	$\"[6-227]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-204]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[5-231]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-211]T$	PTHR19222
PTHR19222:SF16	$\"[6-211]T$	PTHR19222:SF16
SSF52540	$\"[5-251]T$	SSF52540

","BeTs to 11 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.1e-26. IPB001140A 20-66 IPB001140B 125-163 IPB001140C 180-209","Residues 5-56 are 42% similar to a (TRANSPORT ATP-BINDING IRON CHELATIN) protein domain (PD351726) which is seen in Y888_HELPY.Residues 14-209 are 23% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 21-206 are 21% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 25-68 are 59% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9PNS5_CAMJE.Residues 128-170 are 62% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O07016_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:22:49 2002","Thu Mar 14 09:11:20 2002","Thu Oct 17 15:06:58 2002","Thu Mar 14 09:11:20 2002","Thu Mar 14 09:11:20 2002","Thu Mar 14 09:11:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1410 is paralogously related (blast p-value < 1e-3) to SMu0976, SMu0390, SMu1649, SMu0216, SMu1517, SMu1518, SMu0335, SMu0884, SMu1003, SMu0418, SMu1093, SMu0849, SMu0596, SMu1811, SMu0666, SMu0218, SMu0731, SMu0950, SMu1757, SMu1950, SMu0517, SMu1210, SMu0907, SMu0235, SMu1949, SMu1762, SMu0786, SMu0916, SMu0374, SMu1920, SMu1316, SMu1380, SMu0476, SMu1545, SMu1246, SMu1231, SMu0825, SMu0986, SMu0594, SMu1023, SMu1079, SMu0944, SMu0823, SMu1959, SMu0164, SMu1306, SMu1068, SMu1036, SMu1288, SMu0234, SMu1037, SMu0258, SMu0971, SMu0024, SMu0987, SMu0475, SMu0837, SMu0224, SMu1064, SMu1001, SMu1710, SMu0824, SMu0805, SMu1751, SMu1050, SMu1428, SMu0752, SMu1065, SMu0729, SMu0836, SMu1202, SMu1724, and SMu1686 ,all with ATP binding capabilities.","Mon Mar 18 10:50:38 2002","Thu Mar 14 09:11:20 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 81 2e-016pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 80 3e-016","SMU.1551c","","Residues 31 to 203 (E-value = 2.3e-49) place SMu1410 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Mar 14 09:11:20 2002","24379937","","","","","","1","","","SMU.1551c","635" "SMu1411","1478470","1478105","366","ATGACTTATGAAGAAATCAAACTCAGTTTTTTGAAAGGCGGCATTCGTTCTTACAAAGTCTTTCAAGGGCATAAACTCTACTCTCATACTGTCACATCTGAGAACAATCAGAGGCTGATTTCGAAAAGGGTTTACTTAACAAAAAAGAGGCATTACGTCTACTATGAGCGGACAGATGTTAATTGGAATTACTGGGATAAAGGCAAAGAAGACTCAAGTTTTGACCCCAATCAGGTTGAGGAAAATAATGTTTTTGAAATTGCGGATGATTTGAAAACTTTTGCGAAATACTTGGGCAAAGATATTGTTGAGAAACTAGCTGATAAAGTTCAGCATGGCGAGATTGTCGAGTATTTGGATATTTAA","7.00","0.00","14435","MTYEEIKLSFLKGGIRSYKVFQGHKLYSHTVTSENNQRLISKRVYLTKKRHYVYYERTDVNWNYWDKGKEDSSFDPNQVEENNVFEIADDLKTFAKYLGKDIVEKLADKVQHGEIVEYLDI","1478120","","hypothetical protein","Cytoplasm","No significant hit in gapped BLAST found.SMu1411 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:30:07 2002","Thu Mar 14 09:13:32 2002","Wed Oct 9 08:30:07 2002","Thu Mar 14 09:13:32 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1411 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:30:07 2002","","No significant hits to the NCBI PDB database.","SMU.1552c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 09:13:32 2002","24379938","","","","","","1","","","SMU.1552c","" "SMu1412","1478654","1478460","195","ATGAGATCATTGAAATTACTGCTCATTTTTATCGTGATTGTAGCTTTTGTTAGTATTTTGGCTTTGATGACTGATTATTTTGCGGGCATCTCATTATGGCATGTTTACGCACTCATGGGCATTTGTATGACACTGTTTTATGGAATTTTTCCCTATTTTAAAAAAATCGCAGGGAGGAAAGAAAATGACTTATGA","10.00","3.17","7364","MRSLKLLLIFIVIVAFVSILALMTDYFAGISLWHVYALMGICMTLFYGIFPYFKKIAGRKENDL","1478475","","hypothetical protein","Membrane, Cytoplasm","No significant hit in gapped BLAST found.SMu1412 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[5-23]?$ $\"[33-53]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[35-55]?$	transmembrane_regions

InterPro
IPR004664
Domain

Ribonuclease BN
PF03631	$\"[22-279]T$	Ribonuclease_BN
TIGR00765	$\"[12-278]T$	yihY_not_rbn: YihY family protein

noIPR
unintegrated

unintegrated
signalp	$\"[1-49]?$	signal-peptide
tmhmm	$\"[32-52]?$ $\"[92-112]?$ $\"[133-155]?$ $\"[180-200]?$ $\"[210-232]?$ $\"[251-271]?$	transmembrane_regions

","BeTs to 3 clades of COG1295COG name: tRNA-processing ribonuclease BNFunctional Class: JThe phylogenetic pattern of COG1295 is -----q-cEbRhuj----inxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 17-214 are 41% similar to a (PROTEOME COMPLETE YFKH MEMBRANE) protein domain (PD296407) which is seen in Q9CHV5_LACLA.Residues 232-295 are 45% similar to a (PROTEOME YGAB COMPLETE) protein domain (PD390598) which is seen in Q9CHV5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:29:05 2002","Fri Jul 28 11:24:39 2006","Fri Jul 28 11:24:39 2006","Thu Mar 14 09:20:06 2002","","Thu Mar 14 09:20:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1414 is paralogously related (blast p-value < 1e-3) to SMu0917, a predicted ABC transporter permease and substrate binding protein.","Wed Oct 9 08:29:05 2002","","No significant hits to the NCBI PDB database.","SMU.1555c","","Residues 22 to 279 (E-value = 1.7e-61) place SMu1414 in the Ribonuclease_BN family which is described as Ribonuclease BN-like family (PF03631)","Thu Mar 14 09:20:06 2002","24379941","","","","","","1","","","SMU.1555c","667" "SMu1415","1480820","1479960","861","ATGATTACGTTAAAATCACAGCGTGAAATTGAAGCGATGGATGAGGCAGGTGATTTTCTGGCTAGCATTCATATCGGTTTGCGTGATTTGATTAAACCCGGACTTGATATGTGGAAAATTGAAGAATATGTTCGCAGACGTTGTAAGGAAGAGAACTATCTTCCCTTACAAATTGGTGTTGATGGGCAGCTTATGGATTACCCCTACGCAACTTGCTGCGGACTCAATGATGAAGTTGCACACGCCTTTCCACGTCATTATATCTTGAAAGATGGCGATCTTCTTAAGGTTGATATGGTACTTGGCGGTCCTATTGCTAAAGAAGACCTAGATGTCTCAAAATTGAATTTTGACAATGTGGCTCAAGTCAAAAAATATACAGATAGTTTTCGTGGCGGTGTGGCTGATTCCTGCTGGGCCTATGCCGTTGGCGATGTTTCTCAAGAAGTAAAGAATCTAATGGCAGTGACTAAAGAGTGTCTCTATCGTGGAATTGAAAAGGCAGTAGTTGGCAATCGTATTGGTGACATTGGAGCAGCTATTCAAGAATATGCTGAGGCCAACGGTTATGGTGTCGTCCGTGATTTAGTTGGTCATGGTGTTGGCCCAACCATGCATGAAGAACCCAATGTACCACATTATGGCAGAGCAGGACGCGGTCTGCGTTTGAAAGAGGGTATGGTCTTAACTATTGAACCCATGATTAATACCGGCACTTGGGAAATTGATACTGATATGAACACCGGCTGGGCACACAAAACGCTTGATGGCGGATTATCCTGTCAGTATGAGCATCAATTTGTCATTACAAAAGACGGTCCCCGTATTCTAACGAGTCAGGGTCAAGAAGGGACTTATTAA","5.00","-11.34","31731","MITLKSQREIEAMDEAGDFLASIHIGLRDLIKPGLDMWKIEEYVRRRCKEENYLPLQIGVDGQLMDYPYATCCGLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKEDLDVSKLNFDNVAQVKKYTDSFRGGVADSCWAYAVGDVSQEVKNLMAVTKECLYRGIEKAVVGNRIGDIGAAIQEYAEANGYGVVRDLVGHGVGPTMHEEPNVPHYGRAGRGLRLKEGMVLTIEPMINTGTWEIDTDMNTGWAHKTLDGGLSCQYEHQFVITKDGPRILTSQGQEGTY","1479975","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP) and SMu1447 (pepQ). ","methionine aminopeptidase","Cytoplasm, Extracellular","Residues 132-235 are 30% similar to PepQ a previously published sequence from S.mutans (gi2323341).Numerous matches in gapped BLAST to methionine aminopeptidase, type I: residues 1-286 are 87% similar to gi15900953 from S.pneumoniae and 81% similar to gi15675287 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0846 (1e-146).","

InterPro
IPR000994
Domain

Peptidase M24, catalytic core
G3DSA:3.90.230.10	$\"[2-283]T$	Peptidase_M24_cat_core
PTHR10804	$\"[65-101]T$ $\"[129-280]T$	Peptidase_M24_cat_core
PF00557	$\"[135-279]T$	Peptidase_M24

InterPro
IPR002467
Family

Peptidase M24A, methionine aminopeptidase, subfamily 1
PTHR10804:SF13	$\"[65-101]T$ $\"[129-280]T$	Pept_M24A_MAP1
TIGR00500	$\"[2-280]T$	met_pdase_I

noIPR
unintegrated

unintegrated
SSF55920	$\"[1-280]T$	SSF55920

","BeTs to 17 clades of COG0024COG name: Methionine aminopeptidaseFunctional Class: JThe phylogenetic pattern of COG0024 is amtkYqvCeBRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002467 (Methionine aminopeptidase, subfamily 1) with a combined E-value of 3.2e-42. IPB002467A 31-48 IPB002467B 63-84 IPB002467D 189-214 IPB002467E 223-235 IPB002467F 248-278***** PR00599 (Methionine aminopeptidase-1 signature) with a combined E-value of 1.8e-17. PR00599A 71-84 PR00599C 190-202 PR00599D 221-233***** IPB001131 (Proline dipeptidase) with a combined E-value of 4.1e-08. IPB001131C 195-207 IPB001131D 223-236 IPB001131E 260-278","Residues 33-220 are 77% similar to a (AMINOPEPTIDASE METHIONINE HYDROLASE MAP COBALT COMPLETE) protein domain (PD000555) which is seen in Q9CHV6_LACLA.Residues 130-215 are 37% similar to a (AMINOPEPTIDASE DIPEPTIDASE COMPLETE PROTEOME HYDROLASE) protein domain (PD289122) which is seen in O67493_AQUAE.Residues 223-278 are 55% similar to a (AMINOPEPTIDASE METHIONINE MAP HYDROLASE) protein domain (PD102788) which is seen in AMP1_SYNY3.Residues 226-278 are 79% similar to a (AMINOPEPTIDASE METHIONINE COBALT MAP) protein domain (PD357096) which is seen in Q9CHV6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 11 11:22:28 2006","Thu Mar 14 09:22:30 2002","Mon Sep 11 11:22:28 2006","Thu Mar 14 09:22:30 2002","Thu Mar 14 09:22:30 2002","Thu Mar 14 09:22:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1415 is paralogously related (blast p-value < 1e-3) to SMu1447,a predicted PepQ and SMu1685, a predicted aminopeptidase P (XAA-Pro aminopeptidase).","Mon Mar 18 10:44:22 2002","Mon Sep 11 11:22:28 2006","pdb4MATA Chain A, E.Coli Methionine Aminopeptidase His79ala M... 149 5e-037pdb3MATA Chain A, E.Coli Methionine Aminopeptidase Transition... 149 5e-037pdb1C22A Chain A, E. Coli Methionine Aminopeptidase: Trifluor... 149 5e-037","SMU.1556c","","Residues 194 to 268 (E-value = 1.1e-18) place SMu1415 in the Peptidase_M24 family which is described as metallopeptidase family M24 (PF00557)","Thu Mar 14 09:22:30 2002","","","","Wingfield,P., Graber,P., Turcatti,G., Movva,N.R., Pelletier,M.,Craig,S., Rose,K. and Miller,C.G.Purification and characterization of a methionine-specificaminopeptidase from Salmonella typhimuriumEur. J. Biochem. 180 (1), 23-32 (1989)PubMed: 2651123Movva,N.R., Semon,D., Meyer,C., Kawashima,E., Wingfield,P.,Miller,J.L. and Miller,C.G.Cloning and nucleotide sequence of the Salmonella typhimurium pepMgeneMol. Gen. Genet. 223 (2), 345-348 (1990)PubMed: 2250660","","Mon Mar 18 10:43:57 2002","1","","","SMU.1556c","331" "SMu1416","1482121","1480838","1284","ATGAGTAAGCATCAAGATATTCTGGAATATTTAGAAAATCTAACAGTTGGGAAACGTGTCAGTGTTAGAAGTATTTCCAATCATTTAAAGGTTAGTGATGGAACGGCCTATCGTGCGATTAAAGAAGCTGAGAATCGCGGTATTGTTGAAACAAGACCACGCAGCGGTACCATTCGTGTAGAGAAAAAGGTAAGAGTACGTCTCAGTAAATTAACTTATAAGGAAATTGCTAATATCAGTGAGTCTGAAGTCGTTTCGGGCGAATCAGGTCTCGGTCATGAATTCAGCAAGTTTTCTATTGGCGCCATGACAATTGATAATGTTCATCGTTATCTGACAAATGATGGTCTTTTAATTGTTGGCGATCGTGAAGACATTCAACTTCTGGCCTTGGAAAATAAAAATGCTATTTTGGTGACGGGGGGGTTCTCAGTTTCTGAAAAAGTCCTTGATACTTCTAATCTATTAGGTATTCCAGTGATGGTCACCAATTATGACACCTTTACGGTTGCAACCATCATCAATCAAGCCCTGTCCAATGTTCGTATTAAGACAGATATTAAGACCGTAGATGAAGTTTATCAGGAAAAAGTTTATCATGGTTTCTTGCATGATACAGATACTGTTAGGGATTATAACAGTTTAATCAAAAAAACGAACCATGTCCGCTATCCTATTATCAATAGCCATGACATGGTTGTGGGCGTTATCAGTATGCGTGATGTGGCAGGTAAGGACCCTAATATGGTTCTCAATCAATTAATGACGAGAAATCCTGTTGTTGCTAAGTCCAATCTTAGTTTAGCTAACATTAGTCAGAAGATGATTTTTGAAGGTTTTGACATGCTGCCAGTTGTCAAGGAAGATTATAGCCTTTTGGGGGTTATTACGCGCCGTCAGGTTATGGAAAATCTGCAAAACTTTCAAAGAACCAGTTCTCATACCTATAGTGAACAAATCACAGCCAATTTACAGGAAGAAAGAACCGGCTTTCAATTTGTTGTTGAGCCTGCTATGATTGACTCTGCAGGGAATCTAGCTCATGGCGTTTTGACAGAATTTATAAAAGACATTACCATGCGTGTTTTGACACAGAAGCATAAAAAGAATATCATTATTGAGCAAATGATGTTATACTTTTTACAAGCTGTTCAAATTGATGACCTTTTGAAAATACATCCTAAAATTATTACAGAAAATCGACGGAGCGCGACTCTTGACTTTGAAATTTACCATGGCAGTCAAGTGATTACAAAGGCTGTTGTGACAGCAAAATTGAATTAA","8.80","4.16","48184","MSKHQDILEYLENLTVGKRVSVRSISNHLKVSDGTAYRAIKEAENRGIVETRPRSGTIRVEKKVRVRLSKLTYKEIANISESEVVSGESGLGHEFSKFSIGAMTIDNVHRYLTNDGLLIVGDREDIQLLALENKNAILVTGGFSVSEKVLDTSNLLGIPVMVTNYDTFTVATIINQALSNVRIKTDIKTVDEVYQEKVYHGFLHDTDTVRDYNSLIKKTNHVRYPIINSHDMVVGVISMRDVAGKDPNMVLNQLMTRNPVVAKSNLSLANISQKMIFEGFDMLPVVKEDYSLLGVITRRQVMENLQNFQRTSSHTYSEQITANLQEERTGFQFVVEPAMIDSAGNLAHGVLTEFIKDITMRVLTQKHKKNIIIEQMMLYFLQAVQIDDLLKIHPKIITENRRSATLDFEIYHGSQVITKAVVTAKLN","1480853","","conserved hypothetical protein, DRTGG and CBS domains","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical protein and inosine-5'-monophosphate dehydrogenase. Residues 1-427 are 63% similar to gi15675288 as seen in S. pyogenes and are 55% similar to gi15900952 as seen in S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0845 (1e-147).","

InterPro
IPR000644
Domain

Cystathionine-beta-synthase
PF00571	$\"[202-306]T$	CBS
SM00116	$\"[203-247]T$ $\"[258-306]T$	CBS

InterPro
IPR001623
Domain

Heat shock protein DnaJ, N-terminal
PS00636	$\"[168-187]?$	DNAJ_1

InterPro
IPR010766
Domain

DRTGG
PF07085	$\"[75-177]T$	DRTGG

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[3-58]T$	HTH_11

noIPR
unintegrated

unintegrated
PTHR11911	$\"[207-305]T$	PTHR11911
SSF46785	$\"[1-62]T$	SSF46785
SSF54631	$\"[184-243]T$ $\"[245-323]T$	SSF54631
SSF54637	$\"[323-423]T$	SSF54637
SSF75138	$\"[70-182]T$	SSF75138

","BeTs to 10 clades of COG0517COG name: CBS domainsFunctional Class: RThe phylogenetic pattern of COG0517 is AMTKYQVCEBRHUJgpo-inxNumber of proteins in this genome belonging to this COG is 3","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 3.3e-07. IPB000524 19-59","Residues 2-187 are 52% similar to a (PROTEOME COMPLETE SLR0039 VNG0941C) protein domain (PD108213) which is seen in Q9CHJ7_LACLA.Residues 189-303 are 43% similar to a (PROTEOME COMPLETE YHEA) protein domain (PD395561) which is seen in Q9CHJ7_LACLA.Residues 304-426 are 39% similar to a (PROTEOME COMPLETE YHEA BH3175) protein domain (PD091065) which is seen in Q9CHJ7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 10:38:37 2002","Mon Sep 11 11:10:53 2006","Mon Sep 11 11:10:53 2006","Thu Mar 14 09:33:06 2002","Thu Mar 14 09:33:06 2002","Thu Mar 14 09:33:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1416 is paralogously related (blast p-value < 1e-3) to SMu1563, a predicted conserved hypothetical protein.","Mon Mar 18 10:38:37 2002","","No significant hits to the NCBI PDB database.","SMU.1557c","","Residues 75 to 177 (E-value = 1.9e-51) place SMu1416 in the DRTGG family which is described as DRTGG domain (PF07085)Residues 253 to 306 (E-value = 6.1e-11) place SMu1416 in the CBS family which is described as CBS domain (PF00571)","Mon Sep 11 11:10:53 2006","24379943","","","Collart,F.R., Osipiuk,J., Trent,J., Olsen,G.J. and Huberman,E.Cloning, characterization and sequence comparison of the genecoding for IMP dehydrogenase from Pyrococcus furiosusGene 174 (2), 209-216 (1996)PubMed: 8890736","","Mon Mar 18 10:39:55 2002","1","","","SMU.1557c","330" "SMu1417","1482668","1482114","555","ATGGATATATGGACACAGTTAGGACGCTTTTCGGAATTTGAAACACAGCGTCTTTTGATGCGCTCTTTTGCTTTTAAGGATCATAAAGATTTTTATGAAATAGCAAGAGATGCGCAGAATTTAGCATTTATTTTTCCTTGTCAGGCAAATTTGGCAGAAAGTGATTTTTTGTTGGTTCATTATTTTATGAAAAATCCCTTAGGAGTTTGGGCTTTAGAAAACAAACAGGATCATAAAATGATTGGTGCTATTAGATTTGACAAGCTAGATATAATAGCTAAGAGGGCTGAAATAGGTTACTTTTTGCATCGTCATTATTGGAAACAGGGGCTGGCAACCGAAGCACTTGAAAATCTTGTCTTTCTGGCATTTCAAGAACTCGATCTGAAAGAGTTAGAAATTATTGTCCATAAAGAAAACAGAGCAAGTGCAAGAGTGGCAGAAAAGGCGGGATTTAGACTGGTTAGGCAATTTAAGGGAAGCGATAGATACACCCATAAAATGCGTGATTATTTGAAATATGATTTAAAAGCAGGTGATAAAAGTTATGAGTAA","9.10","3.64","21848","MDIWTQLGRFSEFETQRLLMRSFAFKDHKDFYEIARDAQNLAFIFPCQANLAESDFLLVHYFMKNPLGVWALENKQDHKMIGAIRFDKLDIIAKRAEIGYFLHRHYWKQGLATEALENLVFLAFQELDLKELEIIVHKENRASARVAEKAGFRLVRQFKGSDRYTHKMRDYLKYDLKAGDKSYE","1482129","","acetyltransferase, GNAT family","Cytoplasm","Significant hits in gapped BLAST to acetyltransferase and few conserved hypotheticals. Residues 1-180 are 56% similar to gi|15900951| as seen in S.pneumoniae. Residues 1-176 are 51% similar to gi|15675289| as seen in S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0844 (6e-55).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[72-153]T$	Acetyltransf_1
PS51186	$\"[18-177]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[8-180]T$	G3DSA:3.40.630.30
SSF55729	$\"[8-180]T$	SSF55729

","BeTs to 6 clades of COG1670COG name: Acetyltransferases, including N-acetylases of ribosomal proteinsFunctional Class: JThe phylogenetic pattern of COG1670 is ----y-v-EBR-uj-p----xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 96-154 are 40% similar to a (COMPLETE PROTEOME TRANSFERASE) protein domain (PD237114) which is seen in Q9X063_THEMA.Residues 96-151 are 50% similar to a (TRANSFERASE PROTEOME COMPLETE) protein domain (PD000189) which is seen in Q9CHJ8_LACLA.Residues 14-89 are 42% similar to a (PROTEOME TRANSFERASE COMPLETE ACETYL) protein domain (PD199561) which is seen in Q9CHJ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 09:37:42 2002","Thu Mar 14 09:37:10 2002","Thu Oct 17 15:04:52 2002","Thu Mar 14 09:37:10 2002","","Thu Mar 14 09:37:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1417 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 09:37:42 2002","","No significant hits to the NCBI PDB database.","SMU.1558c","","Residues 72 to 153 (E-value = 4e-13) place SMu1417 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Thu Mar 14 09:37:10 2002","24379944","","","","","","1","","","SMU.1558c","788" "SMu1418","1483157","1483570","414","ATGTGGGCATTATTTGCATTTCTTTCCGCCTTATTTGCAGCATTAACCTCAATTCTTGCTAAAATTGGGATTGAGGATGTTAATTCAAACTTAGCAACTGCTATTCGAACTCTTGTAGTACTCTTCTTGGCTTGGGGCATGGTCTTTTTAACAAAAGGTCAGACGGGTTTAACTGACATTAGCAAGAAAAGCTGGACTTTTCTAATTCTTTCTGGTTTAGCAACAGGTGCCTCATGGCTGTGCTACTATCGAGCTCTTCAACTGGGTAAGGCATCAGAGGTTGTTCCTATTGACAAACTCAGCGTTGTGATTACCCTCATTCTTGCTTTTCTTGTTCTGCATGAAGACTTTAGCATAAAATCTTTGATTGGCTGTATACTGATTGGCGGTGGAACTTTGATGATAGTTAGTTAA","8.70","2.13","14709","MWALFAFLSALFAALTSILAKIGIEDVNSNLATAIRTLVVLFLAWGMVFLTKGQTGLTDISKKSWTFLILSGLATGASWLCYYRALQLGKASEVVPIDKLSVVITLILAFLVLHEDFSIKSLIGCILIGGGTLMIVS","1483579","","conserved hypothetical protein","Membrane, Cytoplasm","Limited hits in gapped BLAST to hypotheticals and different kinds of proteins: residues 2-115 are 42% similar to gi|15677676| as seen in N.meningitidis and residues 2-120 are 41% similar to gi|15600637| as seen in Pseudomonas aeruginosa The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1118 (7e-04).","

InterPro
IPR000620
Domain

Protein of unknown function DUF6, transmembrane
PF00892	$\"[11-137]T$	DUF6

noIPR
unintegrated

unintegrated
SSF103481	$\"[35-136]T$	SSF103481

","BeTs to 4 clades of COG0697COG name: Predicted permeasesFunctional Class: RThe phylogenetic pattern of COG0697 is A-tKYQVCEB-Huj---lINxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 73-115 are 60% similar to a (PROTEOME COMPLETE NMB1840 MEMBRANE) protein domain (PD406685) which is seen in Q9JXY1_NEIMB.Residues 78-119 are 50% similar to a (PROTEOME COMPLETE PH1270 COBO) protein domain (PD277895) which is seen in YCB6_PSEDE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:27:56 2002","Thu Mar 14 09:41:57 2002","Thu Mar 14 09:41:57 2002","Thu Mar 14 09:41:57 2002","","Thu Mar 14 09:41:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1418 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:27:56 2002","","No significant hits to the NCBI PDB database.","SMU.1560","","Residues 11 to 137 (E-value = 2.3e-23) place SMu1418 in the DUF6 family which is described as Integral membrane protein DUF6 (PF00892)","Thu Mar 14 09:41:57 2002","24379945","","","","","","1","","","SMU.1560","" "SMu1419","1484317","1483658","660","ATGAAAATTATTATTATCGGTTGTGGCAAGGTTGGAGCTTATGTGGCTAAGCAATTATTGGATTCGCATCATCAAGTAACAATTATTGAGCGAGATCAAAAACGTTTTGAGCAAGTCCTTCAAATATTTTCCCAAGCTGAGGTCTTACATGGAGATGGGACCAGTCCTATTTTACTTGAAAAATGTTCTGTTGAAACAGCGAATGCCGTTGCTTATTTGACGGGAAAAGATGAAATCAATCTTGTAGGGTCAACCGTTGCTAAATTCAACTACGCAGTAGATCGAGTTGTTGCCCGTGTCAATAATCCTAAAAATGAATGGCTTTTTAATGCAGATATGGGGGTGGACAGTCGTGTTAGTCAGGCCAGCCTGCTAGCTAGTGTGATTATCAATGAAGTTAATATTGAAAGTACAGCAACACTACTTAAATTAAATGACGATGAAAATGCGATTGTTGAATTTGTTTTATCAAAAGGCGCTTCTGTTCATGGTAAGACTGTCAAAACAATTAATTTCCCAAGTGATGTTGTTTTGATATCTGTTCATCGTCAAGGACAAAATATTATTCCTAAAGGAGAGACTGTGTTATTGGAAGGGGATCACATTCTAGCTTATACTAACAGTCAAAATCAGGAAAAGCTGGCGCAGCTGTTCCGTTAG","6.30","-2.65","24022","MKIIIIGCGKVGAYVAKQLLDSHHQVTIIERDQKRFEQVLQIFSQAEVLHGDGTSPILLEKCSVETANAVAYLTGKDEINLVGSTVAKFNYAVDRVVARVNNPKNEWLFNADMGVDSRVSQASLLASVIINEVNIESTATLLKLNDDENAIVEFVLSKGASVHGKTVKTINFPSDVVLISVHRQGQNIIPKGETVLLEGDHILAYTNSQNQEKLAQLFR","1483673","For other 'trk' genes see SMu1556 (trkA); SMu1557 (trkH) and SMu1420 (trkA).","potassium uptake protein B","Cytoplasm","Several matches in gapped BLAST to potassium uptake protein: residues 1-217 are 35% similar to the protein in Mycobacterium tuberculosis (gi15609829). Residues 1-217 are 33% similar to the protein from S.coelicolor (gi2815361).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1590 (3e-16).","

InterPro
IPR003148
Domain

TrkA-N
PF02254	$\"[3-121]T$	TrkA_N
PS51201	$\"[2-127]T$	RCK_N

InterPro
IPR006036
Family

TrkA potassium uptake protein
PR00335	$\"[2-16]T$ $\"[19-33]T$ $\"[50-60]T$ $\"[74-88]T$	KUPTAKETRKA

InterPro
IPR006037
Domain

TrkA-C
PF02080	$\"[151-219]T$	TrkA_C
PS51202	$\"[139-219]T$	RCK_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-139]T$	G3DSA:3.40.50.720
SSF51735	$\"[1-219]T$	SSF51735

","BeTs to 12 clades of COG0569COG name: Potassium uptake system NAD-binding component TrkAFunctional Class: PThe phylogenetic pattern of COG0569 is AmtK-Q-CEBRh--gpoL---Number of proteins in this genome belonging to this COG is 3","***** PR00335 (TrkA potassium uptake protein signature) with a combined E-value of 3.2e-10. PR00335A 2-16 PR00335B 19-33 PR00335C 50-60 PR00335E 74-88","Residues 1-129 are 41% similar to a (COMPLETE PROTEOME POTASSIUM TRANSPORT) protein domain (PD001173) which is seen in TRKA_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 13:00:03 2006","Wed Sep 27 13:00:03 2006","Wed Sep 27 12:59:25 2006","Thu Mar 14 09:47:03 2002","Thu Mar 14 09:47:03 2002","Thu Mar 14 09:47:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1419 is paralogously related (blast p-value < 1e-3) to SMu1556, and SMu1420, both predicted potassium uptake proteins.","Thu Mar 14 09:47:03 2002","","No significant hits to the NCBI PDB database.","SMU.1561c","","Residues 2 to 121 (E-value = 9.4e-22) place SMu1419 in the TrkA_N family which is described as TrkA-N domain (PF02254)Residues 151 to 219 (E-value = 2.6e-15) place SMu1419 in the TrkA_C family which is described as TrkA-C domain (PF02080)","Wed Sep 27 12:59:25 2006","","","","","","","1","","","SMU.1561c","" "SMu1420","1484984","1484331","654","ATGAAAATTATTATTGTCGGATGTGGTCGTTTAGGTTCTGGTTTGGCTAATCAATTGAGTCAAGAAGAAAATGATGTTACGGTTATTACGATTGATGAAGACTATTTAGAAGCTTTAGATGATCATTTTACAGGTCAATCTTTGGTAGGAGTTGGCTTTGATAGAGAAATTTTAGTGAAAGCAGGTATTGAGCATGCAGATAGTTTAATTTCCTGTACAGATAGTGATGATACGAATGCTTTGGTGGCCCGTATTGCTAAAAAAATCTACAAAGTTCCTAAGGTCATTGCCAGATTATATGATTCCAGTAAAGTTGATTTATACAATGCGCTAGGCATTCAAGTTATTGCAACAACACAATGGGGGATTGAACGAACCAAGAACCTGCTGACCTTTAAGCATTTTGATTCTGTTTTGAGTCTGGGGAATGGACATTCTACTGTAGAGATTGTACGTTTTAATATTCCTCCTTTGTTGGATAAGAAGAAAATAGAAGAGGTTCTCCCTATCCATGAAGTGCGAGTCATAGCCTTAAGTCGAAAAAATGAGACGTTCATTCCTAATAGAGAAACACTACTGCACTCTCGAGATGTTATCCATTTAGCTGCATCTTCTGATACGGCTAATCAGTTGAGAGAACGCTTTATTTTCTGA","6.20","-3.40","24191","MKIIIVGCGRLGSGLANQLSQEENDVTVITIDEDYLEALDDHFTGQSLVGVGFDREILVKAGIEHADSLISCTDSDDTNALVARIAKKIYKVPKVIARLYDSSKVDLYNALGIQVIATTQWGIERTKNLLTFKHFDSVLSLGNGHSTVEIVRFNIPPLLDKKKIEEVLPIHEVRVIALSRKNETFIPNRETLLHSRDVIHLAASSDTANQLRERFIF","1484346","For other 'trk' genes see SMu1556 (trkA); SMu1557 (trkH) and SMu1419 (trkB).","potassium uptake protein A","Cytoplasm","Significant hits in gapped BLAST to potassium uptake proteins. Residues 1-215 are 30% similar to gi7388326 and gi7480330 as seen in S.coelicolor.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1590 (5e-12).","

InterPro
IPR003148
Domain

TrkA-N
PF02254	$\"[3-119]T$	TrkA_N
PS51201	$\"[2-116]T$	RCK_N

InterPro
IPR006036
Family

TrkA potassium uptake protein
PR00335	$\"[2-16]T$ $\"[19-33]T$ $\"[60-70]T$ $\"[73-87]T$	KUPTAKETRKA

InterPro
IPR006037
Domain

TrkA-C
PF02080	$\"[148-216]T$	TrkA_C
PS51202	$\"[136-217]T$	RCK_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-121]T$	G3DSA:3.40.50.720
SSF51735	$\"[1-215]T$	SSF51735

","BeTs to 11 clades of COG0569COG name: Potassium uptake system NAD-binding component TrkAFunctional Class: PThe phylogenetic pattern of COG0569 is AmtK-Q-CEBRh--gpoL---Number of proteins in this genome belonging to this COG is 3","***** PR00335 (TrkA potassium uptake protein signature) with a combined E-value of 5.1e-10. PR00335A 2-16 PR00335B 19-33 PR00335D 60-70 PR00335E 73-87***** IPB003148 (KTN NAD-binding domain) with a combined E-value of 4.3e-06. IPB003148A 4-16 IPB003148B 50-66","Residues 1-113 are 37% similar to a (COMPLETE PROTEOME POTASSIUM TRANSPORT) protein domain (PD001173) which is seen in O07193_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 12:59:49 2006","Wed Sep 27 12:59:49 2006","Wed Sep 27 12:59:49 2006","Thu Mar 14 09:51:37 2002","Thu Mar 14 09:51:37 2002","Thu Mar 14 09:51:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1420 is paralogously related (blast p-value < 1e-3) to SMu1556, and SMu1419, both predicted potassium uptake proteins.","Mon Mar 18 10:31:08 2002","","No significant hits to the NCBI PDB database.","SMU.1562c","","Residues 2 to 119 (E-value = 4.3e-27) place SMu1420 in the TrkA_N family which is described as TrkA-N domain (PF02254)Residues 148 to 216 (E-value = 3.8e-11) place SMu1420 in the TrkA_C family which is described as TrkA-C domain (PF02080)","Wed Sep 27 12:59:49 2006","","","","Schlosser,A., Hamann,A., Bossemeyer,D., Schneider,E. andBakker,E.P.NAD+ binding to the Escherichia coli K(+)-uptake protein TrkA andsequence similarity between TrkA and domains of a family ofdehydrogenases suggest a role for NAD+ in bacterial transportMolecular microbiology. 9 (3), 533-543 (1993)PubMed: 8412700Bossemeyer,D., Borchard,A., Dosch,D.C., Helmer,G.C., Epstein,W.,Booth,I.R. and Bakker,E.P.K+-transport protein TrkA of Escherichia coli is a peripheralmembrane protein that requires other trk gene products forattachment to the cytoplasmic membraneThe Journal of biological chemistry. 264 (28), 16403-16410 (1989)PubMed: 2674131","","Thu Mar 14 09:51:37 2002","1","","","SMU.1562c","" "SMu1421","1487813","1485021","2793","ATGAGTAGCACAGAACAAGAAACGATGCAGGGAATAGAAAAACTTGTATCTGATGATGTTTATGAAGCTGCACAAACCAGTTCAAATGGACTTGAGGCTTCTCAAGTTCAAAAGCGGCAAGAGTTATATGGTCTCAATCGGTTGAATGAAGTCAAGGGAGAGCCTGTTTGGCTGAAATTTATTAAAAATTTTACCAGTATGATGGCACTCTTGCTCTGGGCAGGCGGTGCAGTTGCCTTCTTTAGCGGGACAATTGAATTGGGGATTGCCATTTGGCTTGTTAATGTTATTAATGGTCTTTTCTCATTTTTCCAAGAGTATCGGGCCAGTCAGGCTACTGAAGCCTTGAAAAAGATGCTCCCTTCATACGCCAGAGTCATCCGTGATGGTAGGGAGAGTAAGATTTTAGCAGAAGAACTGGTTCCCGGAGATGTCATGCTGATTGAGGAAGGAGATGCCATTTCGGCAGATGGGCGTATTATCTTTTCTACTGATTTGCAGGTCAATCAGTCTGCTTTGACGGGTGAGTCCAATCCTGTTCGGAAAAATAATTATCCTGTTCTTGATTCAGACACGGAAAATTTGGAATTTAAAAATATGGTTTTTGCTGGAACTAGTGTATCAAATGGCAGTGCCAAAGTTGTGGTAACGAAAATCGCAATGGCAACCGAATTTGGTAAAATTGCTGATTTGACCCAATCAATGGAAGATGAAAAAAGTCCGCTGCAAAAGGAATTGGACTTATTAACTAAGCAGATTTCTTTGATTGCGGTAACTATTGGTATCTTTTTCTTGCTGGCTTCTGTTTTCTTTGTTAAACAACCTTTAGCCCAAGCCTTTATCTTTTCTCTGGGAATGATTGTCGCTTTTATCCCAGAAGGACTTTTGCCAACAGTTACTTTGTCCCTTGCCATGGCCGTTCAGAGAATGGCCAAGGAGCATGCCTTGGTTAAGAAATTATCTTCAGTAGAAACCTTGGGTGCGACCTCAGTCATTTGTTCTGATAAGACGGGAACCTTGACCCAAAATGAAATGACAGTCAACCATGTTTGGACTTTAAATCATGAATACGAAGTGACAGGTCAAGGTTATGCTTCTGATGGACATTTAGAAAGAAATAATCAGGAAGTTACAGTTGCCAATGAAGAGGGTTTAGAGTTCTTACTGAGAGCAGCAGCACTTTGTTCCAATGCACGTGTTCTAGCACCTAGTGATGGAAATCCTCGTTATACGGTTCTAGGAGATCCAACAGAAGCCTGCTTAAATGTTGTGGCTGAAAAAGCAGGGATTGACTTAACTGAAAATGAAACTTGGGCACAAAGAGTGAGAGAATTACCGTTTGATTCCAGCCGTAAGCGAATGACGACTGTGCATCGACTAAAACAACCTGTAAATGGTTCGTCCTTCATTTCAATTACCAAAGGAGCTCCTAAAGAGACCTCTGAGCTTTGTAACAAGGTTTATGAGAATGGTCAGCTGAGAGATTTGACTGATACAGATCGGGAAGCTATTTTAGCGGCTAATGATGATTATGCGCGTCAAGGTTTGCGTGTTTTAGCAGTTGCCTATCGTAATCTAGAAGAAGTAGCTGACCTTCCCAAAGCCTTGTCTGACTATAGTCCAGAAGTCATTGAAGAGGATATGGTTTTTCAAGGTTTAGTGGTTATGGCAGATCCTCCGCGTGAAGAAGTGGCAGCGGCTGTTGAGTTATGCCGTAAGGCAAGCATTCGTATTGTCATGGTTACAGGAGATTATGGTTTAACAGCTGTCAGCATTGCCAAACGGATTGGTATTGTCCAAGGGGAAAATCCTCGTGTGGTTACTGGCCTAGAATTAAAAGATATGTCAGATGATGACTTGAAACAGGCCTTATCAGATGAAGTTGTCTTTGCCCGTGTAGCGCCCGAACAAAAATATCGTGTTGTTACCAATCTGCAAGCTTTGGGACATGTTGTTGCTGTAACAGGTGATGGTGTCAATGATGCCCCAGCCTTGAAAAAAGCTGATATTGGAGTGGCAATGGGGATTACAGGGACAGATGTTGCTAAGGAATCTGCGGATATGATTTTGACAGATGACAATTTTGCTTCTATTGTACGCGCTGTTGAAGAGGGGCGTGCTGTCTATACCAACATTCGGAAATTCCTGACTTATATCTTTAATAGTAATACCTCGGAGGCCGTGCCTTCTGCAGCTTTTCTTTTTTCCAAAGGAGGTATTCCTTTACCTTTAACCGTTATGCAGATTTTAGCGATTGACCTAGGAACGGATATGATTCCTGCCCTTGGTTTAGGCGTCGAAGAAGCTGAAGATGGGATTATGGAACGTCCCCCTCGGCGTCCAACAGACCGTCTGCTCAACAAAGGTTTATTGATAAAGGCCTTTATTTGGTATGGCCTTTTAGAAGCAGCTATTGCTATGGGAGCTTTCTTCTTTACTTATGCTATTGGCGGCGGTTTAAGTGGGCATTTGGCGTCATCAGGTCAGCTCTATCAGCAGGCAACAACAATGACTCTTGGTGCTATTATCTTTTGCCAGTTGGGAATGGTGATGAATACACGTACTGAAAAGGCCTCTATCTTTAAAGTGAAACTCTTTTCAAATAAGGTCATTAATTTTGGTATGATGTTTGAAATTTTCTTATTCTGTCTTTTAGCTTACCTACCATTTTTACATGGTCTCTTCAACACGGCGGCAATAGGTGTGTGGCATTGGCTCTATTTGATTCTCTGTCCAATTCCAGTTTTGTTTATTGAGGAAGCTCGTAAGGCTTATATGAGAAGAAAACACTAA","4.90","-22.86","101909","MSSTEQETMQGIEKLVSDDVYEAAQTSSNGLEASQVQKRQELYGLNRLNEVKGEPVWLKFIKNFTSMMALLLWAGGAVAFFSGTIELGIAIWLVNVINGLFSFFQEYRASQATEALKKMLPSYARVIRDGRESKILAEELVPGDVMLIEEGDAISADGRIIFSTDLQVNQSALTGESNPVRKNNYPVLDSDTENLEFKNMVFAGTSVSNGSAKVVVTKIAMATEFGKIADLTQSMEDEKSPLQKELDLLTKQISLIAVTIGIFFLLASVFFVKQPLAQAFIFSLGMIVAFIPEGLLPTVTLSLAMAVQRMAKEHALVKKLSSVETLGATSVICSDKTGTLTQNEMTVNHVWTLNHEYEVTGQGYASDGHLERNNQEVTVANEEGLEFLLRAAALCSNARVLAPSDGNPRYTVLGDPTEACLNVVAEKAGIDLTENETWAQRVRELPFDSSRKRMTTVHRLKQPVNGSSFISITKGAPKETSELCNKVYENGQLRDLTDTDREAILAANDDYARQGLRVLAVAYRNLEEVADLPKALSDYSPEVIEEDMVFQGLVVMADPPREEVAAAVELCRKASIRIVMVTGDYGLTAVSIAKRIGIVQGENPRVVTGLELKDMSDDDLKQALSDEVVFARVAPEQKYRVVTNLQALGHVVAVTGDGVNDAPALKKADIGVAMGITGTDVAKESADMILTDDNFASIVRAVEEGRAVYTNIRKFLTYIFNSNTSEAVPSAAFLFSKGGIPLPLTVMQILAIDLGTDMIPALGLGVEEAEDGIMERPPRRPTDRLLNKGLLIKAFIWYGLLEAAIAMGAFFFTYAIGGGLSGHLASSGQLYQQATTMTLGAIIFCQLGMVMNTRTEKASIFKVKLFSNKVINFGMMFEIFLFCLLAYLPFLHGLFNTAAIGVWHWLYLILCPIPVLFIEEARKAYMRRKH","1485036","","cation-transporting P-ATPase","Membrane, Cytoplasm","This sequence corresponds to the previously published gi9965435 in GenBank, a predicted CopA sequence. Numerous hits in gapped BLAST to cation-transporting P-ATPase PacL: residues 8-928 are 45% similar to gi15679513 from Methanothermobacter thermoautotrophicum. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0911 (0.0).","

InterPro
IPR001757
Family

ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119	$\"[169-183]T$ $\"[333-347]T$ $\"[552-563]T$ $\"[574-584]T$ $\"[655-674]T$ $\"[679-691]T$	CATATPASE
PTHR11939	$\"[12-784]T$	ATPase_P
TIGR01494	$\"[90-354]T$ $\"[629-747]T$	ATPase_P-type
PS00154	$\"[335-341]?$	ATPASE_E1_E2

InterPro
IPR004014
Domain

ATPase, P-type cation-transporter, N-terminal
PF00690	$\"[6-84]T$	Cation_ATPase_N

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[329-678]T$	Hydrolase

InterPro
IPR006068
Domain

ATPase, P-type cation-transporter, C-terminal
PF00689	$\"[776-929]T$	Cation_ATPase_C

InterPro
IPR006069
Family

ATPase, P-type cation exchange, alpha subunit
PR00121	$\"[71-85]T$ $\"[252-274]T$ $\"[326-347]T$ $\"[471-489]T$ $\"[729-750]T$ $\"[798-818]T$	NAKATPASE

InterPro
IPR008250
Domain

E1-E2 ATPase-associated region
PF00122	$\"[90-325]T$	E1-E2_ATPase

noIPR
unintegrated

unintegrated
G3DSA:1.20.1110.10	$\"[629-928]T$	G3DSA:1.20.1110.10
G3DSA:2.70.150.10	$\"[9-212]T$	G3DSA:2.70.150.10
G3DSA:3.40.1110.10	$\"[343-559]T$	G3DSA:3.40.1110.10
PTHR11939:SF85	$\"[12-784]T$	PTHR11939:SF85
SSF56784	$\"[320-701]T$	SSF56784
SSF81653	$\"[120-232]T$	SSF81653
SSF81660	$\"[342-560]T$	SSF81660
SSF81665	$\"[9-929]T$	SSF81665

","BeTs to 9 clades of COG0474COG name: Cation transport ATPasesFunctional Class: PThe phylogenetic pattern of COG0474 is -mT-Yq-CebR---gp-----Number of proteins in this genome belonging to this COG is 2","***** IPB001757 (E1-E2 ATPases) with a combined E-value of 8e-33. IPB001757A 332-343 IPB001757B 646-675","Residues 490-624 are 36% similar to a (F ATP-BINDING PHOSPHORYLATION MAGNESIUM) protein domain (PD266100) which is seen in CTPF_MYCTU.Residues 258-347 are 60% similar to a (ATPASE HYDROLASE TRANSMEMBRANE ATP-BINDING) protein domain (PD000466) which is seen in O27560_METTH.Residues 777-928 are 33% similar to a (ATPASE CALCIUM HYDROLASE TRANSMEMBRANE PHOSPHORYLATION) protein domain (PD000388) which is seen in O27560_METTH.Residues 440-562 are 34% similar to a (ATPASE HYDROLASE TRANSMEMBRANE) protein domain (PD336512) which is seen in ATMA_ECOLI.Residues 629-702 are 41% similar to a (TRAX) protein domain (PD162139) which is seen in Q50124_MYCLE.Residues 15-80 are 42% similar to a (ATPASE HYDROLASE TRANSMEMBRANE ATP-BINDING) protein domain (PD005738) which is seen in P73273_SYNY3.Residues 666-773 are 32% similar to a (ATPASE INTEGRAL CATION-TRANSPORTING) protein domain (PD189829) which is seen in Q9CHZ3_LACLA.Residues 89-216 are 48% similar to a (ATPASE HYDROLASE TRANSMEMBRANE ATP-BINDING) protein domain (PD000132) which is seen in O27560_METTH.Residues 509-571 are 47% similar to a (ATPASE HYDROLASE TRANSMEMBRANE PHOSPHORYLATION) protein domain (PD000138) which is seen in O27560_METTH.Residues 575-667 are 36% similar to a (ATPASE-LIKE CA2-TRANSPORTING) protein domain (PD241169) which is seen in Q9LVV1_ARATH.Residues 574-624 are 58% similar to a (PROTEOME COMPLETE CATION-TRANSPORTING) protein domain (PD384521) which is seen in P73273_SYNY3.Residues 368-779 are 25% similar to a (CG3701) protein domain (PD309831) which is seen in Q9W248_DROME.Residues 572-665 are 52% similar to a (ATPASE HYDROLASE TRANSMEMBRANE PHOSPHORYLATION) protein domain (PD000121) which is seen in O27082_METTH.Residues 666-757 are 65% similar to a (ATPASE HYDROLASE CALCIUM TRANSMEMBRANE PHOSPHORYLATION) protein domain (PD000140) which is seen in P73273_SYNY3.Residues 388-487 are 36% similar to a (ATPASE HYDROLASE ALPHA PHOSPHORYLATION TRANSMEMBRANE) protein domain (PD000320) which is seen in O27560_METTH.Residues 674-757 are 48% similar to a (ATPASE HYDROLASE ATP-BINDING TRANSMEMBRANE) protein domain (PD274998) which is seen in Q9P872_CANAL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 10:02:06 2002","Wed Sep 27 12:54:35 2006","Wed Sep 27 12:54:35 2006","Thu Mar 14 10:01:54 2002","Thu Mar 14 10:01:54 2002","Thu Mar 14 10:01:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1421 is paralogously related (blast p-value < 1e-3) to SMu0660 and SMu1867, both predicted cation-transporting P-ATPase PacL; SMu0386,a predicted copper-transporting ATPase.","Thu Mar 14 10:04:01 2002","Wed Sep 27 12:54:35 2006","pdb1EULA Chain A, Crystal Structure Of Calcium Atpase With Tw... 481 2e-136","SMU.1563c","","Residues 6 to 84 (E-value = 5.9e-18) place SMu1421 in the Cation_ATPase_N family which is described as Cation transporter/ATPase, N-terminus (PF00690)Residues 90 to 325 (E-value = 6.4e-98) place SMu1421 in the E1-E2_ATPase family which is described as E1-E2 ATPase (PF00122)Residues 329 to 678 (E-value = 2.6e-21) place SMu1421 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)Residues 776 to 929 (E-value = 4.1e-37) place SMu1421 in the Cation_ATPase_C family which is described as Cation transporting ATPase, C-terminus (PF00689)","Wed Sep 27 12:54:35 2006","","","","Kanamaru,K., Kashiwagi,S. and Mizuno,T.The cyanobacterium, Synechococcus sp. PCC7942, possesses twodistinct genes encoding cation-transporting P-type ATPasesFEBS Lett. 330 (1), 99-104 (1993)PubMed: 8370468","Tue Apr 2 18:26:14 2002","Thu Mar 14 10:01:54 2002","1","","","SMU.1563c","" "SMu1422","1490361","1488085","2277","ATGACACAAAAAACAAAACAATTCAGTAAGTATGTCCAAGAAAAAACCGGTCAAAATTTGGAACAATTAAGCAATGAAGCTATTTATGTTCAGCTTTTGCACTTTGTCAAAGAGGCTGCCAAAGACATGCCTAAAAATACGTCTAAACGTAAAGTATATTATATCTCTGCTGAGTTCCTGATTGGGAAATTACTGTCAAATAATCTGATAAATTTAGGTCTTTATAAGACCGTTAAGGATGAATTAGCTGCTGCTGGTAAGTCCATCAGCCAAGTAGAAGATGTGGAATTAGAACCATCACTTGGTAACGGTGGTTTGGGACGCTTAGCTTCTTGTTTTATTGATTCGATGGCAACGCTGGGTATTAATGGTGAAGGTGTTGGACTTAATTACCACTGCGGACTTTTTAAGCAAGTTTTTCGTGATAATCAGCAGGAAGCTGAACCCAATTACTGGATTGAAGATGATTCTTGGCTAGTGCCAACGGCTATTTCATATGATGTGCCTTTCCGTGATTTTACGCTTAAGTCAAAATTAGATCGTATTGATATTTTGGGCTATCACAAGGATAGTAAGAATTACTTAAATCTCTTTGATATTGATGGTCTTGATTATGGCTTGATTAAGGATGGTATTACTTTTGATAAGACTGAAATTAAGAAAAATCTGACTCTTTTCCTTTATCCTGATGATTCTGATAAAAATGGGGAATTGCTGCGTATTTATCAACAATATTTCATGGTTTCAAATGCAGCACAGCTCTTGATTGACGAAGCGCTTGAGCGCGGTTCAAATCTGCATGACTTGGCTGATTATGCCTATGTGCAAATCAACGATACCCATCCATCAATGGTTATTCCAGAGCTTATCCGTCTCTTGAATGAAAAACATGGTTTAGATTTCTATGAAGCTGTAGATATTGTGAAAAATATGATTGGTTATACCAACCATACGATTTTAGCAGAAGCTCTTGAAAAATGGCCTTTGGAATATTTAAATGAAGTTGTCCCACATTTGGTAACCATTATTGAACATCTAGACCGTATCGTTCGCAGTCAGTATAAGGATGATGCTGTTCAAATTATCGATAGAGATGATCGGGTTCACATGGCTCACATGGATATTCATTTTTCAACCAGTGTTAACGGAGTTGCTGCTCTCCATACTGATATTTTGAAAAACAGTGAATTGAAACCCTTCTATGATATTTATCCTGAAAAATTCAATAACAAGACTAATGGGATTACTTTCCGTCGGTGGTTGGAATTTGCCAATCAAGACTTGGCAGCCTATATTAAAGAATTAATTGGTGAAGGTTATCTTGAAGATGCGACTGAGCTTGAAAAATTATTGGCTTTTGCGGATGACAAGACTGTTCATGAGCAGCTGGCAAAAATCAAATTTAACAATAAATTAGCTCTTAAACGCTATCTCAAGGAAAATAAGGGAATTAACCTTGATGAAAATTCTATCATTGATACGCAAATCAAGCGTTTCCATGAATATAAACGTCAGCAAATGAATGCTCTTTATGTTATTTATAAGTATCTTGAAATCAAAAAAGGCAATCTTCCAAAACGTAAAATTACTGTGATCTTTGGTGGTAAAGCAGCACCGGCTTATACCATTGCCCAAGACATTATTCATTTGATTCTTTGCTTATCAGAGCTTATCAATAATGATCCGGATGTTAGTCCTTACCTTAATGTTTTCCTTGTTGAAAATTATAATGTCACTGTGGCAGAAAAATTAATCCCTGCTACTGATATTTCGGAACAAATTTCTTTGGCTTCAAAAGAGGCTTCTGGTACAGGTAACATGAAATTCATGCTTAACGGTGCTTTAACACTGGGTACGATGGATGGTGCCAATGTGGAGATTGCTGAACTTGTCGGTTCAGATAATATCTACATTTTTGGTAAGGATTCAGATACCATTATTGATTTGTATGACAAGGGAACTTATGTTTCTAAGGATTATTATACTAATAATGCAGTCATTAAAGAAGCCGTTGATTTCATCGTTAGTAAGGATGTCCTTGCGCTAGGTAAAAAAGAACGTTTAGAACGTCTTTACCATGAGCTTATCAATAAAGATTGGTTCATGACACTGATTGACTTGAAAGAATACATTGCTAAGAAAGAAGAAATGTTAGCTGATTATGAGGACCAAAATGTATGGAATAAAAAGGTTATTCAAAACATCGCTAAAGCTGGTTTCTTCTCATCAGACAGAACAATCCAACAATACGATAAGGACATTTGGCATAGTTTGTAA","5.10","-22.72","86809","MTQKTKQFSKYVQEKTGQNLEQLSNEAIYVQLLHFVKEAAKDMPKNTSKRKVYYISAEFLIGKLLSNNLINLGLYKTVKDELAAAGKSISQVEDVELEPSLGNGGLGRLASCFIDSMATLGINGEGVGLNYHCGLFKQVFRDNQQEAEPNYWIEDDSWLVPTAISYDVPFRDFTLKSKLDRIDILGYHKDSKNYLNLFDIDGLDYGLIKDGITFDKTEIKKNLTLFLYPDDSDKNGELLRIYQQYFMVSNAAQLLIDEALERGSNLHDLADYAYVQINDTHPSMVIPELIRLLNEKHGLDFYEAVDIVKNMIGYTNHTILAEALEKWPLEYLNEVVPHLVTIIEHLDRIVRSQYKDDAVQIIDRDDRVHMAHMDIHFSTSVNGVAALHTDILKNSELKPFYDIYPEKFNNKTNGITFRRWLEFANQDLAAYIKELIGEGYLEDATELEKLLAFADDKTVHEQLAKIKFNNKLALKRYLKENKGINLDENSIIDTQIKRFHEYKRQQMNALYVIYKYLEIKKGNLPKRKITVIFGGKAAPAYTIAQDIIHLILCLSELINNDPDVSPYLNVFLVENYNVTVAEKLIPATDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAELVGSDNIYIFGKDSDTIIDLYDKGTYVSKDYYTNNAVIKEAVDFIVSKDVLALGKKERLERLYHELINKDWFMTLIDLKEYIAKKEEMLADYEDQNVWNKKVIQNIAKAGFFSSDRTIQQYDKDIWHSL","1488100","For other 'glg' genes see SMu1396 (glgP); SMu1397 (glgA); SMu1398 (glgD); SMu1399 (glgC); SMu1400 (glgB) and SMu1539 (glg3). From Genbank:[gi:730325]This enzyme is an important allosteric enzyme in carbohydrate metabolism.Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates.However, all known phosphorylases share catalytic and structural properties.","glycogen phosphorylase","Cytoplasm","Matches in gapped BLAST to glycogen phosphorylase:residues 589-756 are 45% similar to the previously published enzyme in S.mutans (gi|7433828|). Residues 7-757 are 82% similar to glycogen phosphorylase in S. pyogenes (gi|15675244|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1438 (0.0).","

InterPro
IPR000811
Family

Glycosyl transferase, family 35
PIRSF000460	$\"[3-758]T$	Pprylas_GlgP
PTHR11468	$\"[50-755]T$	Glyco_trans_35
PF00343	$\"[82-756]T$	Phosphorylase
PS00102	$\"[600-612]T$	PHOSPHORYLASE

InterPro
IPR011833
Family

Glycogen/starch/alpha-glucan phosphorylase
TIGR02093	$\"[2-757]T$	P_ylase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2000	$\"[1-444]T$	G3DSA:3.40.50.2000
SSF53756	$\"[1-756]T$	SSF53756

","BeTs to 9 clades of COG0058COG name: Glucan phosphorylaseFunctional Class: GThe phylogenetic pattern of COG0058 is -m-kyq-CEbrh------in-Number of proteins in this genome belonging to this COG is 2","***** IPB000811 (Glycosyltransferase family 35) with a combined E-value of 2.3e-197. IPB000811A 50-92 IPB000811B 96-135 IPB000811D 220-259 IPB000811E 301-347 IPB000811F 368-420 IPB000811G 486-520 IPB000811H 528-571 IPB000811I 585-639 IPB000811J 721-758","Residues 50-232 are 38% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN GLYCOSYLTRANSFERASE) protein domain (PD002266) which is seen in PHSG_ECOLI.Residues 368-411 are 61% similar to a (PHOSPHORYLASE PHOSPHATE STARCH PYRIDOXAL) protein domain (PD404360) which is seen in O08329_BACST.Residues 367-410 are 70% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN PYRIDOXAL TRANSFERASE) protein domain (PD002287) which is seen in Q9KDX7_BACHD.Residues 606-755 are 41% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN PHOSPHATE CARBOHYDRATE) protein domain (PD002288) which is seen in PHSG_BACSU.Residues 412-604 are 46% similar to a (PHOSPHORYLASE GLYCOGEN METABOLISM) protein domain (PD010784) which is seen in PHSG_HAEIN.Residues 412-605 are 49% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN PHOSPHATE CARBOHYDRATE) protein domain (PD001956) which is seen in PHS2_RABIT.Residues 215-336 are 40% similar to a (PHOSPHORYLASE METABOLISM GLYCOGEN GLYCOSYLTRANSFERASE) protein domain (PD001939) which is seen in PHS2_DICDI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:02:07 2002","Thu Mar 14 10:05:31 2002","Thu Oct 17 15:02:07 2002","Thu Mar 14 10:05:31 2002","Thu Mar 14 10:05:31 2002","Thu Mar 14 10:05:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1422 is paralogously related (blast p-value < 1e-3) to SMu1396, also a predicted glycogen phosphorylase.","Thu Mar 14 10:08:32 2002","Thu Mar 14 10:05:31 2002","pdb|1EM6|A Chain A, Human Liver Glycogen Phosphorylase A Comple... 507 2e-144pdb|1FC0|A Chain A, Human Liver Glycogen Phosphorylase Complexe... 507 2e-144pdb|1FA9|A Chain A, Human Liver Glycogen Phosphorylase A Comple... 507 2e-144","SMU.1564c","","Residues 82 to 756 (E-value = 6.8e-193) place SMu1422 in the Phosphorylase family which is described as Carbohydrate phosphorylase (PF00343)","Thu Mar 14 10:05:31 2002","","","Smith,A.J., Quivey,R.G. Jr. and Faustoferri,R.C. Cloning and nucleotide sequence analysis of the Streptococcus mutans membrane-bound, proton-translocating ATPase operon Gene 183 (1-2), 87-96 (1996) PubMed: 8996091 ","Kiel,J.A., Boels,J.M., Beldman,G. and Venema,G.Glycogen in Bacillus subtilis: molecular characterization of anoperon encoding enzymes involved in glycogen biosynthesis anddegradationMol. Microbiol. 11 (1), 203-218 (1994)PubMed: 8145641","Thu Mar 14 10:08:03 2002","Mon Mar 18 10:29:35 2002","1","","","SMU.1564c","152" "SMu1423","1491862","1490333","1530","ATGGAAAAACGCGCAAGTGGTATCCTGATGCATATCAGTTCTCTACCGGGAAAATTTGGAATTGGTACTTTTGGGCAGGAAGCTTATGATTTTGTTGATTTCCTAAAAAAAACAGGTCAAACATATTGGCAGCTCTTACCCTTAACGACAACGAGTTATGGTGATTCTCCTTACCAATCTTTTTCTGCCGTTGCTGGTAATGTGAATTTTATTGATTTTAAGAAATTACAAGAAGCTGGCTTATTGGACGAGGATGACTATAATTCTGTTTCTTTTGGAGAAGACGAAGAAATTGTTGATTATGCTCTATTATTTAAAGTACGTCGGCCAATTTTGGAAAAGGCTGTTATCAATTTTCTGGCAGACAAGACTAATCTGAAAAAATTAGCTTTGTTTGAAGAAAAAAATGAAACTTGGCTTGATGACTATGCTGAATTTATGGCCATCAAGGAGCATTTTGGCAATAAGTCTTTGCAAGAGTGGGGCGATAAAAAGGCTATTCGCCGTGATGAGGAGCGTTTGGTACGTTATCGTCATTTGTTGGCCGATGAAATTAGCTACCATAAGGTTACACAGTACTTCTTCTTCGAACAATGGCTGGCGCTGAAAGCTTATGCTAATAAAAATAAGATCAAAATTATTGGCGATATGCCTATCTATGTAGCTAAAGACAGTGTTGAAGTCTGGACTATGCCTGAACTCTTTAAGATGGATGATGACTTGCAGCCTTTGTCGGTTGCTGGCTGTCCGCCCGATGAATTTAGTGATGAGGGTCAGTTGTGGGGAAATCCTATTTATGATTGGAAAAAGCATCGAGAAACAGGCTTTGCTTGGTGGATTTATCGTATTCAAGAAAGTTTTAAGATCTATGATATCTTACGGATAGATCACTTTAAAGGTTTCTCAGATTATTGGGAAATTAAAGGTAATTCCAAAACTGCAAAAAATGGCAGCTGGCATCCAGGACCTGGTATTGCTCTCTTTAGGGCTGTTCAAAATGTTTTGGGCGATATGCCAATTATTGCAGAGGATTTGGGTTACGTAGATGATAGAGCCAGACAGCTTCTAAAAGAAACAGGCTTTCCAGGCATGAAAATTTTAGAATTTGGTTTCTATGATTTAAGCGGCCGCAGTGTTGATATTCCCCACCATTATGTTCAAAATAGTGTTGCTTATATTGGGACGCATGATAATGATGTTGTCAATGGTTGGTATGATCGTCTTACTGTTGAGCAAGAAGAATTTGTGGATGCTTATACTAATCGTAAGCCAATTGAGCCGGTTAATCAGGCTATGCTTAGACTGCTCTTTTCAACTGTCAGCAATACAGCTATTTTAACCATGCAGGATTTGCTCAATAAGCCAGCCAGCTCTAGAATGAATACCCCATCAACAATCGGCGGTAACTGGCAATGGCGGATGAGAGCAAAAGATTTAACACAAGATAAAATAAACTTTTTAAGTAAATTAACGAAACTTTATCAAAGAGGAAATGAAGAAAATGACACAAAAAACAAAACAATTCAGTAA","5.50","-9.59","58943","MEKRASGILMHISSLPGKFGIGTFGQEAYDFVDFLKKTGQTYWQLLPLTTTSYGDSPYQSFSAVAGNVNFIDFKKLQEAGLLDEDDYNSVSFGEDEEIVDYALLFKVRRPILEKAVINFLADKTNLKKLALFEEKNETWLDDYAEFMAIKEHFGNKSLQEWGDKKAIRRDEERLVRYRHLLADEISYHKVTQYFFFEQWLALKAYANKNKIKIIGDMPIYVAKDSVEVWTMPELFKMDDDLQPLSVAGCPPDEFSDEGQLWGNPIYDWKKHRETGFAWWIYRIQESFKIYDILRIDHFKGFSDYWEIKGNSKTAKNGSWHPGPGIALFRAVQNVLGDMPIIAEDLGYVDDRARQLLKETGFPGMKILEFGFYDLSGRSVDIPHHYVQNSVAYIGTHDNDVVNGWYDRLTVEQEEFVDAYTNRKPIEPVNQAMLRLLFSTVSNTAILTMQDLLNKPASSRMNTPSTIGGNWQWRMRAKDLTQDKINFLSKLTKLYQRGNEENDTKNKTIQ","1490348","For other 'mal' genes see SMu1424 (malR); SMu1425 (malE); SMu1426 (malF) and SMu1427 (malG).","4-alpha-glucanotransferase","Cytoplasm","Several matches in gapped BLAST to 4-alpha-glucanotransferase: residues 1-496 are 62% similar to the enzyme in S.pyogenes (gi|15675245|). Residues 1-499 are 55% similar to the protein from S.pneumoniae (gi|15903958|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1439 (0.0).","

InterPro
IPR003385
Family

Glycoside hydrolase, family 77
PF02446	$\"[10-494]T$	Glyco_hydro_77
TIGR00217	$\"[1-496]T$	malQ

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[3-497]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
SSF51445	$\"[3-496]T$	SSF51445

","BeTs to 6 clades of COG1640COG name: 4-alpha-glucanotransferaseFunctional Class: GThe phylogenetic pattern of COG1640 is -----q-ce-rh----o-in-Number of proteins in this genome belonging to this COG is 1","***** IPB003385 (4-alpha-glucanotransferase) with a combined E-value of 6.6e-70. IPB003385A 13-26 IPB003385B 56-78 IPB003385C 187-222 IPB003385D 248-277 IPB003385E 278-310 IPB003385F 461-473","Residues 2-130 are 61% similar to a (4-ALPHA-GLUCANOTRANSFERASE METABOLISM AMYLOMALTASE) protein domain (PD186621) which is seen in MALQ_STRPN.Residues 139-474 are 55% similar to a (4-ALPHA-GLUCANOTRANSFERASE METABOLISM AMYLOMALTASE) protein domain (PD005929) which is seen in MALQ_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 15:01:24 2002","Thu Mar 14 10:10:28 2002","Thu Oct 17 15:01:24 2002","Thu Mar 14 10:10:28 2002","Thu Mar 14 10:10:28 2002","Thu Mar 14 10:10:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1423 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 10:12:19 2002","","No significant hits to the NCBI PDB database.","SMU.1565c","","Residues 10 to 494 (E-value = 2.5e-204) place SMu1423 in the 4a_glucanotrans family which is described as 4-alpha-glucanotransferase (PF02446)","Thu Mar 14 10:10:28 2002","","","","Goda,S.K., Eissa,O., Akhtar,M. and Minton,N.P.Molecular analysis of a Clostridium butyricum NCIMB 7423 geneencoding 4-alpha-glucanotransferase and characterization of therecombinant enzyme produced in Escherichia coliMicrobiology 143 (Pt 10), 3287-3294 (1997)PubMed: 9353929","","Thu Mar 14 10:13:23 2002","1","","","SMU.1565c","153" "SMu1424","1492996","1491977","1020","ATGGTTACTATTAAGGATGTTGCAAAAGAGGCAGGTGTGAATCCTTCTACTGTCAGTCGGGTTTTAAAAAACAGTTCCTCCATTTCGCAAAAAACGAAAGATAGGGTTCAACAGGCTATGACAGATTTAGGTTATGTGCCTAATTTAGCTGCTCAAATGCTGGCTAGTGGCTTGACTCACTGTGTCGGTGTTGTTTTCCCGCCTTTAACAAGTCCAGATCGTTTAAGCGAACCTTTTTTCATGGAAATATTGGCAGCTATTAATAATGAAGCAAGCCGTAATAAATTCACAGTTTCGATTGCGACCAGTAATACTTTGACGGATCTAAAAGATCAGGTACAGCTCATGTATCGGCAAGGGCGAGTGGATGGTTTTATCGTGCTTTACTCAGAAAGAAGGGATCCTGTACGTCAATATCTGATCAAAAATAAAATTCCTTTTGTCATTGTCGGTGCTCCAGTTGATTATAAAGATGAAACGACCTATGTTGATAATGATAACCAATTAATGGCTGAGACTGCTGTGACTTACCTCAATCAAAAAGGGCATAAGCAGATTTTATTTGTCACAAATGATCAAGAAAGTGATGTTTATATTGAGCGTTTTATCGGCTATCAAAAGGGAATGCAAGCATTAGGTTTACAGTCATATGACAGTGCTCTTTTTGATTCTAAACAAGCTAGCACGCTAGAAGCCTTTATTAAAACTGTTCAGAAAAAAAAAATAACGGCTCTCCTTATTATTGGGGATGTCGTTTCTCTTCGGATTATTCAATTTTTGTCTTATTATGGTATAGCTGTACCAGAAGATATGTCTATTGTGTCTTTTAATAATTCCAGTTATGCCACTATTTTGCATCCTTATTTAACAACATTTGATATTAATGTTAATCGTTTAGGAAGAGCGAGTCTGAATTGTTTGTTGGAAAAAGTGCAAAAGCGTCAGTCAAAAGATCAGAAAGTAATCGTTCCTTTTACTTTGAAAAAACGTGAGAGTGTCCGTAATCTTAAAAAAAGCTAG","10.10","9.63","38089","MVTIKDVAKEAGVNPSTVSRVLKNSSSISQKTKDRVQQAMTDLGYVPNLAAQMLASGLTHCVGVVFPPLTSPDRLSEPFFMEILAAINNEASRNKFTVSIATSNTLTDLKDQVQLMYRQGRVDGFIVLYSERRDPVRQYLIKNKIPFVIVGAPVDYKDETTYVDNDNQLMAETAVTYLNQKGHKQILFVTNDQESDVYIERFIGYQKGMQALGLQSYDSALFDSKQASTLEAFIKTVQKKKITALLIIGDVVSLRIIQFLSYYGIAVPEDMSIVSFNNSSYATILHPYLTTFDINVNRLGRASLNCLLEKVQKRQSKDQKVIVPFTLKKRESVRNLKKS","1491992","For other 'mal' genes see SMu1423 (malM); SMu1425 (malE); SMu1426 (malF) and SMu1427 (malG).","maltose operon transcriptional repressor","Cytoplasm, Periplasm, Membrane","This sequence corresponds to the previously published gi2155300 and gi2495405 from S.mutans. In addition,significant hits in gapped BLAST to maltose operon transcriptional repressor: residues 1-336 are 59% similar to gi15675246 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1440 (1e-114).","

InterPro
IPR000843
Domain

Bacterial regulatory protein, LacI
PR00036	$\"[3-13]T$ $\"[13-23]T$	HTHLACI
PF00356	$\"[2-27]T$	LacI
SM00354	$\"[1-71]T$	HTH_LACI
PS50932	$\"[2-56]T$	HTH_LACI_2

InterPro
IPR001761
Domain

Periplasmic binding protein/LacI transcriptional regulator
PF00532	$\"[59-331]T$	Peripla_BP_1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[2-57]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[2-59]T$	G3DSA:1.10.260.40
G3DSA:3.40.50.2300	$\"[166-305]T$	G3DSA:3.40.50.2300
SSF53822	$\"[59-336]T$	SSF53822

","BeTs to 4 clades of COG1609COG name: Transcriptional regulators of the LacI familyFunctional Class: KThe phylogenetic pattern of COG1609 is ------V-EBrH---------Number of proteins in this genome belonging to this COG is 5","***** IPB000843 (Bacterial regulatory protein, LacI family) with a combined E-value of 2.2e-26. IPB000843A 3-23 IPB000843B 28-66","Residues 3-82 are 65% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000947) which is seen in Q9CF05_LACLA.Residues 83-141 are 45% similar to a (PROTEOME TRANSCRIPTIONAL REGULATION) protein domain (PD338955) which is seen in Q9CF05_LACLA.Residues 1-136 are 35% similar to a (TRANSCRIPTION REPRESSOR REGULATION) protein domain (PD023303) which is seen in MALR_STAXY.Residues 142-278 are 40% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000591) which is seen in Q9ZI78_BBBBB.Residues 113-336 are 23% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD400719) which is seen in Q9CHK6_LACLA.Residues 279-334 are 39% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD384527) which is seen in Q9CF05_LACLA.Residues 63-142 are 31% similar to a (TRANSCRIPTION REGULATION DNA-BINDING) protein domain (PD274558) which is seen in Q9K8T0_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 10:58:08 2006","Thu Mar 14 10:18:01 2002","Thu Aug 31 10:58:08 2006","Thu Mar 14 10:18:01 2002","Thu Mar 14 10:18:01 2002","Thu Mar 14 10:18:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1424 is paralogously related (blast p-value < 1e-3) to SMu1446, a predicted catabolite control protein A; SMu1679, a predicted sucrose operon repressor; SMu0094,a predicted SCR operon transcriptional repressor; and SMu0807, a predicted galactose repressor.","Mon Mar 18 10:25:07 2002","Thu Aug 31 10:58:08 2006","pdb1BDHA Chain A, Purine Repressor Mutant-Hypoxanthine-Palind... 118 9e-028pdb2PUAA Chain A, Crystal Structure Of The Laci Family Member... 117 2e-027pdb2PUEA Chain A, Crystal Structure Of The Laci Family Member... 116 3e-027","SMU.1566c","","Residues 2 to 27 (E-value = 1.3e-09) place SMu1424 in the LacI family which is described as Bacterial regulatory proteins, lacI family (PF00356)Residues 59 to 331 (E-value = 1.8e-08) place SMu1424 in the Peripla_BP_1 family which is described as Periplasmic binding proteins and sugar binding domain of the LacI family (PF00532)","Thu Aug 31 10:58:08 2006","","","","O'Connell-Motherway,M., van Sinderen,D., Morel-Deville,F.,Fitzgerald,G.F., Ehrlich,S.D. and Morel,P.Six putative two-component regulatory systems isolated fromLactococcus lactis subsp. cremoris MG1363Microbiology 146 (Pt 4), 935-947 (2000)PubMed: 10784052","Thu Aug 31 10:58:08 2006","Thu Aug 31 10:58:08 2006","1","","","SMU.1566c","586" "SMu1425","1493243","1494490","1248","ATGAAAACATGGCAAAAAATCGTCGTTGGCGGTGCAGGCCTTATGCTTGCAAGCAGTATTCTTGTTGCCTGTGGATCAAAGGATTCAAAATCAAGTTCATCTGATCCCAAAACCATTAAACTTTGGGTTCCAACAGGAGCCAAGAAATCTTATCAAAGTATTGTTCACAAATTTGAAAAGGATTCTAACTATAAAGTAAAGATTATTGAATCTGAAGACCCAAAAGCTCAGGAAAAGATCAAAAAAGATCCTAGTACTGCTGCAGATGTTTTCTCGCTGCCGCATGATCAGCTGGGCCAGTTAGTTGACTCTGGTGTTATCCAAGAGATTCCTCAAAAATATTCAAAAGAAATAAATAAAAATGAAACACAGCAGGCTGCAACAGGAGCTATGTACAAAGGTAAGACTTATGCTTTTCCTTTTGGAATCGAGTCTCAAGTACTTTACTATAATAAATCAAAACTCTCAGCTGATGATGTCACATCATATGAGACTATTACCAGCAAGGCAACTTTCGGAGCAAAATTCAAACAAGTTAATGCCTATGCGACTGCACCACTTTTCTATTCAGTAGGTGATACACTCTTTGGTAAAAATGGCGAAGATGCCAAAGGAACTAACTGGGGAAATGATGCTGGTGTATCTGTTTTGAAATGGATTGCCAGTCAAAAAGGTAACGCTGGCTTTGTCAATCTTGACGATAACAATGTCATGTCTAAATTTGGTGATGGTTCTGTAGCTTCTTTTGAATCAGGTCCTTGGGATTATGAAGCCGCACAAAAGGCAGTTGGCAAAAACAACCTCGGTGTTACGGTTTATCCAACAATAAATATTAATGGTCAAGAAGTTCAACAGAAAGCTTTCTTAGGTGTTAAACTCTACGCTGTTAATCAAGCTCCTTCTAAAGGAAATACCAAACGTATTGCTGCTAGTTATAAATTAGCTTCTTACTTAACAAGTGCTGAAAGCCAAGAAAATCAATTTAAGACAAAAGGACGCAACATCATCCCATCTAATAAGACCGTTCAAAACTCTGATACAGTCAAAAATCATGAACTCGCACAGGCTGTTATCCAAATGGGATCTTCTTCAGATTATACTGTTGTTATGCCTAAACTCAACCAAATGTCAACATTCTGGACGGAAAGCGCAGCTATTCTTAGTGATACTTACAATGGTAAAATTAAAGAAAGTGATTACCTTGCTAAATTAAAACAATTTGATAAAGATTTAGCAGCTGCTAAATAA","10.00","10.69","45162","MKTWQKIVVGGAGLMLASSILVACGSKDSKSSSSDPKTIKLWVPTGAKKSYQSIVHKFEKDSNYKVKIIESEDPKAQEKIKKDPSTAADVFSLPHDQLGQLVDSGVIQEIPQKYSKEINKNETQQAATGAMYKGKTYAFPFGIESQVLYYNKSKLSADDVTSYETITSKATFGAKFKQVNAYATAPLFYSVGDTLFGKNGEDAKGTNWGNDAGVSVLKWIASQKGNAGFVNLDDNNVMSKFGDGSVASFESGPWDYEAAQKAVGKNNLGVTVYPTININGQEVQQKAFLGVKLYAVNQAPSKGNTKRIAASYKLASYLTSAESQENQFKTKGRNIIPSNKTVQNSDTVKNHELAQAVIQMGSSSDYTVVMPKLNQMSTFWTESAAILSDTYNGKIKESDYLAKLKQFDKDLAAAK","1494499","For other components see SMu1428 (NBD1); SMu1426 (MSD1) and SMu1427 (MSD2).For other 'mal' genes see SMu1423 (malM); SMu1424 (malR); SMu1426 (malF) and SMu1427 (malG).","maltose / maltodextrin-binding protein","Membrane, Periplasm","Matches in gapped BLAST to maltose/maltodextrin-binding protein: residues 1-415 are 74% similar to the protein in S.pyogenes (gi|15675247|).Residues 1-414 are 35% similar to the protein in Lactococcus lactis (gi|15673665|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1441 (1e-163).","

InterPro
IPR006059
Family

Bacterial extracellular solute-binding protein, family 1
PF01547	$\"[8-325]T$	SBP_bac_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[33-371]T$	G3DSA:3.40.190.10
PS51257	$\"[1-24]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[37-392]T$	SSF53850

","BeTs to 4 clades of COG2182COG name: Maltose-binding periplasmic proteins/domainsFunctional Class: GThe phylogenetic pattern of COG2182 is ---k--V-eB-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 161-230 are 44% similar to a (PROTEOME BINDING COMPLETE MALTOSE) protein domain (PD390438) which is seen in Q9CEZ8_LACLA.Residues 244-343 are 39% similar to a (TRANSPORT PERIPLASMIC COMPLETE) protein domain (PD023543) which is seen in Q9CEZ8_LACLA.Residues 41-156 are 38% similar to a (COMPLETE PROTEOME SUGAR TRANSPORT) protein domain (PD001485) which is seen in Q9CEZ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:25:04 2002","Thu Oct 17 15:00:12 2002","Thu Oct 17 15:00:12 2002","Thu Mar 14 10:33:20 2002","","Thu Mar 14 10:33:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1425 is paralogously related (blast p-value < 1e-3) to SMu1781 and SMu0801,both predicted sugar-binding periplasmic protein; and SMu0739, a predicted amino acid ABC transporter, periplasmic amino acid-binding protein.","Thu Mar 14 10:33:20 2002","Thu Mar 14 10:33:20 2002","pdb|1ELJ|A Chain A, The Crystal Structure Of Liganded Maltodext... 83 6e-017pdb|1MDP|1 Chain 1, Maltodextrin-Binding Protein (Male178 Mutan... 83 6e-017pdb|1MDQ| Maltodextrin-Binding Protein (Male322) (Maltose-Bi... 82 2e-016","SMU.1568","","Residues 8 to 325 (E-value = 8.5e-25) place SMu1425 in the SBP_bac_1 family which is described as Bacterial extracellular solute-binding protein (PF01547)","Thu Mar 14 10:33:20 2002","24379952","","","Puyet,A. and Espinosa,M.Structure of the maltodextrin-uptake locus of Streptococcuspneumoniae. Correlation to the Escherichia coli maltose regulonJ. Mol. Biol. 230 (3), 800-811 (1993)PubMed: 8478935Martin,B., Alloing,G., Boucraut,C. and Claverys,J.P.The difficulty of cloning Streptococcus pneumoniae mal and ami loci in Escherichia coli: toxicity of malX and amiA gene productsGene 80 (2), 227-238 (1989)PubMed: 2684766","","Thu Mar 14 10:33:20 2002","1","","","SMU.1568","949" "SMu1426","1494567","1495928","1362","ATGATTCAGTCATCTTCTCATGATCAGTTATCTGTACTTGAAACTTTTAAAAAGGGCGGGATAGATATCAAATTATCGTTTGTCATCATGGGATTTGCCAATTTGATGAATAAGCAATTCATAAAAGGCCTCCTCTTTCTATTAAGTGAGATAGCTTTTCTAATTGCTTTTGTCACACAGGTTATTCCAGCTTTTTCAGGCTTACTCACTCTCGGTACTAAAACACAAGGGATGCAAGAAAAAATTGTGGATGGCGTTAAATTACAGGTGGCAGTTGAAGGCGATAATTCGATGCTGATGCTCATTTTTGGATTAGCCTCACTAATCTTTTGTTTGGTTTTTGCCTACATTTATTGGTGTAATCTTAAAAGTGCCAGAAATCTCTATATGTTAAAAAAAGAGGGACGTCACATTCCATCTTTCAAAGAAGATTTTATGACTTTGGCAAACGGCCGATTCCATATGACTTTGATGTTTATTCCTTTGATTGGTGTTCTTCTTTTTACCATTTTGCCACTCGTTTATATGATTTGCCTGGCCTTTACCAATTATGATCACAATCATCTTCCGCCTAAATCCCTTTTTGATTGGGTAGGGTTGGCTAATTTTGGTAATGTTTTGAATGGCCGCATGGCTGGAACCTTCTTCCCTGTCCTTTCTTGGACACTTATCTGGGCTGTTTTCGCAACTGTGACAAACTTTCTTTTTGGAGTCATCTTGGCACTTATTATCAATGCTAAGGGATTAAAATTGAAAAAAATGTGGCGGACTATCTTTGTTATTACCATTGCTGTGCCGCAGTTCATTTCACTTTTGCTGATGAGAAATTTCCTTAATGATCAAGGTCCGCTCAATGCTTTCCTAGAAAAAATTGGCCTGATTTCTCATTCTCTGCCATTTCTATCAGATCCTACTTGGGCAAAATTTTCAATTATCTTCGTTAATATGTGGGTTGGTATTCCTTTTACCATGTTAGTCGCAACAGGAATTATCATGAATCTTCCGAGTGAGCAAATTGAGGCTGCAGAAATTGACGGCGCTAGTAAGTTCCAAATTTTTAAATCCATCACTTTCCCGCAGATTCTTTTAATTATGATGCCATCTTTAATCCAGCAATTTATTGGAAATATCAATAATTTTAATGTCATCTACCTTTTAACCGGTGGCGGACCAACTAATTCACAATTCTATCAAGCAGGCAGCACAGACTTATTGGTCACTTGGCTTTATAAACTAACAATGAATGCTGCAGACTATAATTTAGCTTCTGTTATTGGTATCTTTATCTTTGCCATTTCAGCTATCTTCAGTCTTTTAGCTTATACGCATACAGCATCATACAAGGAAGGAGCTGTTAAATAA","9.80","8.54","50626","MIQSSSHDQLSVLETFKKGGIDIKLSFVIMGFANLMNKQFIKGLLFLLSEIAFLIAFVTQVIPAFSGLLTLGTKTQGMQEKIVDGVKLQVAVEGDNSMLMLIFGLASLIFCLVFAYIYWCNLKSARNLYMLKKEGRHIPSFKEDFMTLANGRFHMTLMFIPLIGVLLFTILPLVYMICLAFTNYDHNHLPPKSLFDWVGLANFGNVLNGRMAGTFFPVLSWTLIWAVFATVTNFLFGVILALIINAKGLKLKKMWRTIFVITIAVPQFISLLLMRNFLNDQGPLNAFLEKIGLISHSLPFLSDPTWAKFSIIFVNMWVGIPFTMLVATGIIMNLPSEQIEAAEIDGASKFQIFKSITFPQILLIMMPSLIQQFIGNINNFNVIYLLTGGGPTNSQFYQAGSTDLLVTWLYKLTMNAADYNLASVIGIFIFAISAIFSLLAYTHTASYKEGAVK","1495937","For other components see SMu1428 (NBD1); SMu1427 (MSD2) and SMu1425 (SBP1).For other 'mal' genes see SMu1423 (malM); SMu1424 (malR); SMu1425 (malE) and SMu1427 (malG).From Genbank:[gi:547883]This protein is part of the binding-protein-dependent transport system for maltodextrin.It is probably responsible for the translocation of the substrate across the membrane.","maltodextrin ABC transport system permease","Membrane, Cytoplasm","Residues 156-394 are 26% similar to a previously published protein in S.mutans (gi|153738|),(gi|547926|) and (gi|282318|). Significant hits in gapped BLAST to maltose/maltodextrin ABC transport system (permease):residues 1-453 are 76% similar to the protein from S.pyogenes (gi|15675248|).Residues 14-450 are 47% similar to the protein from Lactococcus lactis (gi|15673666|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1442 (0.0).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[215-449]T$	BPD_transp_1
PS50928	$\"[219-440]T$	ABC_TM1

","BeTs to 8 clades of COG1175COG name: ABC-type sugar transport systems, permease componentsFunctional Class: GThe phylogenetic pattern of COG1175 is --TK--VCEBR---gp-l---Number of proteins in this genome belonging to this COG is 2","***** IPB000515 (Binding-protein-dependent transport systems inner membrane component) with a combined E-value of 6.4e-07. IPB000515 340-359","Residues 28-125 are 35% similar to a (TRANSPORT TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD312314) which is seen in Q48396_KLEOX.Residues 333-421 are 44% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in Q48396_KLEOX.Residues 215-269 are 41% similar to a (TRANSPORT MALTODEXTRIN SYSTEM MALC) protein domain (PD012833) which is seen in MALC_STRPN.Residues 214-269 are 46% similar to a (TRANSPORT TRANSMEMBRANE PROTEOME PERMEASE) protein domain (PD000737) which is seen in Q9KBA8_BACHD.Residues 215-321 are 59% similar to a (PROTEOME COMPLETE GENES ABCDEFGHIJ) protein domain (PD414911) which is seen in Q9CEZ7_LACLA.Residues 14-148 are 38% similar to a (PROTEOME COMPLETE MALTOSE ABC) protein domain (PD398328) which is seen in Q9CEZ7_LACLA.Residues 323-365 are 69% similar to a (TRANSPORT TRANSMEMBRANE PERMEASE COMPLETE PROTEOME SUGAR) protein domain (PD000120) which is seen in Q9CEZ7_LACLA.Residues 152-206 are 50% similar to a (TRANSPORT TRANSMEMBRANE SUGAR COMPLETE) protein domain (PD189539) which is seen in Q9CEZ7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 08:18:53 2002","Mon Oct 28 08:18:43 2002","Thu Oct 17 14:59:39 2002","Thu Mar 14 10:44:15 2002","Thu Mar 14 10:44:15 2002","Thu Mar 14 10:44:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1426 is paralogously related (blast p-value < 1e-3) to SMu0802, a predicted multiple sugar-binding transport system permease protein MsmF; SMu0885 and SMu0886,both predicted spermidine / putrescine ABC transporter (permease protein); SMu0803,a predicted multiple sugar-binding transport system permease protein MsmG; SMu0848, SMu1382, SMu1080, SMu0219 and SMu0732, all predicted permeases.","Thu Mar 14 10:44:15 2002","","No significant hits to the NCBI PDB database.","SMU.1569","","Residues 215 to 449 (E-value = 1.6e-13) place SMu1426 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Thu Mar 14 10:44:15 2002","24379953","","","Puyet,A. and Espinosa,M.Structure of the maltodextrin-uptake locus of Streptococcuspneumoniae. Correlation to the Escherichia coli maltose regulonJ. Mol. Biol. 230 (3), 800-811 (1993)PubMed: 8478935","","Mon Mar 18 10:23:19 2002","1","","","SMU.1569","833" "SMu1427","1495928","1496764","837","ATGAAAAGAAAAAAACAACTTCAGATCGGCTCTATCTATGCTTTACTGATTCTCTTATCCTTCATTTGGCTATTTCCGATCATTTGGGTTATACTGACGAGTTTTCGCGGTGAAGGCACAGCTTATGTTCCTTATATTATTCCAAAAACGTGGACTTTAGATAATTATATTAAATTATTTACCAATTCTTCTTTCCCATTTGGACGCTGGTTTTTAAATACCTTAATCGTTTCAACAGCCACTTGTGTTCTGTCAACTTCTATCACAGTGGCAATGGCTTATTCGCTTAGCCGTATTAAATTTAAACACCGTAACGGCTTTTTAAAATTAGCTCTTGTTCTGAATATGTTTCCGGGATTTATGAGTATGATTGCAGTTTACTACATTCTAAAAGCACTCAATCTCACCCAAACATTAACATCTCTTGTTTTGGTCTATTCTTCAGGAGCTGCCTTAACTTTCTATATCGCTAAAGGCTTTTTTGATACGATTCCTTATTCATTGGATGAATCAGCTATGATTGATGGGGCTACGCGTAAAGATATTTTCTTAAAAATCACTCTGCCGCTATCTAAGCCCATCATCGTTTATACGGCCCTGTTGGCATTTATTGCCCCTTGGATTGACTTTATTTTTGCTCAGGTTATTCTTGGAGATGCCACCAGCAAATATACCGTAGCGATTGGACTCTTCTCTATGCTTCAAGCTGATACCATTAATAATTGGTTCATGGCCTTTGCAGCAGGTTCTGTACTGATCGCCATTCCAATCACGATACTTTTTATCTTCATGCAAAAGTATTACGTTGAAGGCATTACTGGCGGATCTGTTAAATAA","10.50","11.17","31171","MKRKKQLQIGSIYALLILLSFIWLFPIIWVILTSFRGEGTAYVPYIIPKTWTLDNYIKLFTNSSFPFGRWFLNTLIVSTATCVLSTSITVAMAYSLSRIKFKHRNGFLKLALVLNMFPGFMSMIAVYYILKALNLTQTLTSLVLVYSSGAALTFYIAKGFFDTIPYSLDESAMIDGATRKDIFLKITLPLSKPIIVYTALLAFIAPWIDFIFAQVILGDATSKYTVAIGLFSMLQADTINNWFMAFAAGSVLIAIPITILFIFMQKYYVEGITGGSVK","1496773","For other components see SMu1428 (NBD1); SMu1426 (MSD1) and SMu1425 (SBP1).For other 'mal' genes see SMu1423 (malM); SMu1424 (malR); SMu1425 (malE) and SMu1426 (malF).","maltose / maltodextrin ABC transport system (permease)","Membrane, Cytoplasm","Residues 1-278 are 26% similar to a previously published proteinin S.mutans (gi|153739|),(gi|547927|) and (gi|282319|). Significant hits in gapped BLAST to maltose/maltodextrin ABCtransport system (permease):residues 1-278 are 84% similar to theprotein from S.pyogenes (gi|15675249|).Residues 2-278 are 51%similar to the protein from Lactococcus lactis (gi|15673667|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1443 (1e-137).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[67-274]T$	BPD_transp_1
PS50928	$\"[71-264]T$	ABC_TM1

","BeTs to 8 clades of COG0395COG name: Sugar permeasesFunctional Class: GThe phylogenetic pattern of COG0395 is --TK--VCEBR---gp-l---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 72-149 are 47% similar to a (TRANSPORT TRANSMEMBRANE PERMEASE SUGAR) protein domain (PD330158) which is seen in Q9CEZ6_LACLA.Residues 5-145 are 24% similar to a (MG189 TRANSMEMBRANE ABC TRANSPORT) protein domain (PD031935) which is seen in Y189_MYCGE.Residues 13-266 are 20% similar to a (TRANSPORTER C SUBUNIT GLYCEROL) protein domain (PD305527) which is seen in Q9RFW5_BBBBB.Residues 154-203 are 68% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in Q9CEZ6_LACLA.Residues 224-278 are 49% similar to a (TRANSPORT TRANSMEMBRANE PERMEASE SYSTEM) protein domain (PD189269) which is seen in Q9K8S9_BACHD.Residues 211-278 are 51% similar to a (TRANSPORT PERMEASE SUGAR PROTEOME) protein domain (PD001620) which is seen in Q9CEZ6_LACLA.Residues 2-65 are 43% similar to a (TRANSPORT PROTEOME TRANSMEMBRANE COMPLETE) protein domain (PD079704) which is seen in Q9CEZ6_LACLA.Residues 20-144 are 23% similar to a (TRANSPORT SUGAR MEMBRANE) protein domain (PD332866) which is seen in Q9ZI16_STRLI.Residues 155-195 are 58% similar to a (TRANSPORT TRANSMEMBRANE PERMEASE COMPLETE PROTEOME SUGAR) protein domain (PD000120) which is seen in Q48397_KLEOX.Residues 4-73 are 36% similar to a (YCJP MEMBRANE INNER ABC) protein domain (PD079748) which is seen in YCJP_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 15:22:25 2002","Thu Oct 17 14:58:54 2002","Thu Oct 17 14:58:39 2002","Thu Mar 14 12:54:11 2002","","Thu Mar 14 12:54:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1427 is paralogously related (blast p-value < 1e-3) to SMu0803 ,a predicted multiple sugar-binding transport system permease protein MsmG; SMu0802,a predicted multiple sugar-binding transport system permease protein MsmF; SMu0886 and SMu0885,both predicted spermidine / putrescine ABC transporter (permease protein); and SMu0756, a predicted hypothetical protein.","Thu Mar 14 12:54:11 2002","","No significant hits to the NCBI PDB database.","SMU.1570","","Residues 67 to 274 (E-value = 1.6e-17) place SMu1427 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Thu Mar 14 12:54:11 2002","24379954","","","","","","1","","","SMU.1570","" "SMu1428","1496789","1497922","1134","ATGACAACTTTAAAACTTGATAACATCTACAAAAGATATCCCAATGCAAAGCATTATTCCGTTGAAAATTTTAATCTTGACATTCATGATAAAGAATTTATTGTCTTTGTCGGTCCTTCAGGATGCGGAAAGTCAACCACTCTTCGCATGATTGCTGGGCTGGAAGATATTACAGAAGGCAACCTTTATATTGATGATAAACTCATGAATGATGCCTCTCCTAAAGATCGCGATATTGCTATGGTTTTTCAAAATTATGCTCTTTATCCTCATATGAGCGTTTATGAAAATATGGCTTTTGGCCTAAAACTTCGTAAATACAAAAAAGATGATATTAATAAACGTGTACACGAAGCTGCTGAAATTCTTGGACTGACAGAATTTCTTGAAAGAAAGCCTGCGGACCTCTCTGGCGGACAGCGGCAGCGGGTTGCTATGGGACGTGCTATTGTCCGAGATGCTAAGGTCTTCTTAATGGACGAACCTTTGTCAAATTTAGATGCCAAACTTCGAGTTGCCATGCGAGCCGAAATCGCTAAAATTCACCGCCGCATTGGGGCAACGACTATCTATGTTACCCATGACCAAACAGAAGCCATGACCTTAGCAGATCGTATTGTTATCATGAGCGCTACTCCAAACCCAGATAAAACCGGCTCTATCGGTCGTATTGAGCAGATTGGAACACCACAGGAACTCTACAATGAACCTGCTAATAAATTTGTTGCTGGCTTCATCGGAAGCCCCGCTATGAATTTCTTTGAAGTGACCGTTGAAAAAGAGCGTTTGGTTAACCAAGATGGTCTAAGCCTTGCGCTTCCTCAGGGACAGGAAAAAATTCTTGAGGAGAAAGGTTATCTTGGTAAAAAAGTCACTTTAGGTATTCGACCAGAAGACATCTCAAGTGATCAAATTGTCCACGAGACTTTCCCAAATGCCAGTGTTACAGCTGACATACTAGTATCAGAACTTTTAGGCAGCGAAAGCATGTTATATGTCAAATTTGGCAGTACTGAATTTACAGCTCGCGTCAATGCTCGTGACTCTCACAGTCCCGGAGAAAAAGTACAATTAACCTTTAATATTGCTAAGGGACACTTCTTTGATTTAGAGACTGAAAAACGAATCAATTAA","6.40","-2.85","42314","MTTLKLDNIYKRYPNAKHYSVENFNLDIHDKEFIVFVGPSGCGKSTTLRMIAGLEDITEGNLYIDDKLMNDASPKDRDIAMVFQNYALYPHMSVYENMAFGLKLRKYKKDDINKRVHEAAEILGLTEFLERKPADLSGGQRQRVAMGRAIVRDAKVFLMDEPLSNLDAKLRVAMRAEIAKIHRRIGATTIYVTHDQTEAMTLADRIVIMSATPNPDKTGSIGRIEQIGTPQELYNEPANKFVAGFIGSPAMNFFEVTVEKERLVNQDGLSLALPQGQEKILEEKGYLGKKVTLGIRPEDISSDQIVHETFPNASVTADILVSELLGSESMLYVKFGSTEFTARVNARDSHSPGEKVQLTFNIAKGHFFDLETEKRIN","1497931","For other components see SMu1426 (MSD1); SMu1427 (MSD2) and SMu1425 (SBP1).For other 'msm' genes see SMu0799 (msmR); SMu0801 (msmE); SMu0802 (msmF); SMu0803 (msmG); SMu0805 (msmK); SMu1079 (msmK); SMu0594 (msmK) and SMu0884 (msmK).","ABC-type transport system ATP-binding protein (maltose)","Cytoplasm, Membrane","Matches in gapped BLAST to multiple sugar-binding transport ATP-binding protein: residues 1-377 are 76% similar to a previously published protein in S.mutans (gi282320) and (gi547928). Residues 1-376 are 79% similar to the protein from S.pyogenes (gi15675768) and are 73% similar to the protein from Lactococcus lactis (gi15672403). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1925 (1e-171).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[136-178]T$	ABC_transporter
PF00005	$\"[31-212]T$	ABC_tran
PS00211	$\"[136-150]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-246]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-239]T$	AAA

InterPro
IPR008995
Domain

Molybdate/tungstate binding
SSF50331	$\"[248-376]T$	MOP_like

InterPro
IPR013611
Domain

Transport-associated OB
PF08402	$\"[293-368]T$	TOBE_2

noIPR
unintegrated

unintegrated
G3DSA:2.40.50.100	$\"[251-315]T$	G3DSA:2.40.50.100
G3DSA:3.40.50.300	$\"[1-249]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-306]T$	PTHR19222
PTHR19222:SF42	$\"[4-306]T$	PTHR19222:SF42
SSF52540	$\"[4-270]T$	SSF52540

","BeTs to 10 clades of COG1130COG name: ABC-type sugar transport system, ATPase componentFunctional Class: GThe phylogenetic pattern of COG1130 is -mtK--VCEBRh--GP-L---Number of proteins in this genome belonging to this COG is 4","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.4e-30. IPB001140A 20-66 IPB001140B 133-171","Residues 180-234 are 43% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472) which is seen in Q9V286_PYRAB.Residues 339-376 are 76% similar to a (ATP-BINDING TRANSPORT SUGAR MULTIPLE) protein domain (PD069931) which is seen in MSMK_STRMU.Residues 267-338 are 51% similar to a (ATP-BINDING TRANSPORT ABC SUGAR) protein domain (PD186376) which is seen in Q9CIE2_LACLA.Residues 180-230 are 56% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9KWT9_BBBBB.Residues 73-109 are 91% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD259496) which is seen in O87551_BACFI.Residues 179-213 are 94% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9CIE2_LACLA.Residues 111-230 are 30% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in Q9CCF9_MYCLE.Residues 32-209 are 25% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 228-259 are 87% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD001887) which is seen in MSMK_STRMU.Residues 236-376 are 30% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD407629) which is seen in O57942_PYRHO.Residues 21-71 are 82% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CIE2_LACLA.Residues 136-178 are 97% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in MSMK_STRMU.Residues 271-336 are 57% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD020401) which is seen in MSMK_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:46:42 2007","Thu Oct 24 15:11:38 2002","Tue Apr 24 10:46:42 2007","Thu Mar 14 11:03:05 2002","Thu Mar 14 11:03:05 2002","Thu Mar 14 11:03:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1428 is paralogously related (blast p-value < 1e-3) to SMu0805, SMu0884, SMu1003, SMu0971, SMu0594, SMu1920, SMu1079, SMu0418, SMu0731, SMu1950, SMu1210, SMu0517, SMu1288, SMu1380, SMu1762, SMu0849, SMu1068, SMu1949, SMu0235, SMu1246, SMu1231, SMu0218, SMu0390, SMu1751, SMu1518, SMu1757, SMu0786, SMu1001, SMu0216, SMu0916, SMu1316, SMu1649, SMu0234, SMu0950, SMu0824, SMu0596, SMu1064, SMu1517, SMu1023, SMu0164, SMu1036, SMu0335, SMu0825, SMu1037, SMu0976, SMu0907, SMu0374, SMu0836, SMu0986, SMu1065, SMu0476, SMu0837, SMu1710, SMu0944, SMu0258, SMu0987, SMu0475, SMu0752, SMu1724, SMu1811, SMu1410, SMu0024, SMu0823, SMu1545, SMu1306, SMu1050, SMu1093, SMu0666, SMu0224, SMu0729, SMu1959 and SMu1686, all with ATP binding capabilities.","Tue Apr 2 13:47:14 2002","Tue Apr 24 10:46:42 2007","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 360 2e-100pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 102 9e-023","SMU.1571","","Residues 31 to 212 (E-value = 5.1e-63) place SMu1428 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 309 to 367 (E-value = 4.4e-06) place SMu1428 in the TOBE family which is described as TOBE domain (PF03459)","Tue Apr 24 10:46:42 2007","24379955","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992)PubMed: 1537846Russell RR, Ferretti JJNucleotide sequence of the dextran glucosidase (dexB) gene of Streptococcus mutans.J Gen Microbiol 1990 May;136 ( Pt 5):803-10PubMed: 2380687PMID: 2380687 Aduse-Opoku J, Tao L, Ferretti JJ, Russell RRBiochemical and genetic analysis of Streptococcus mutans alpha-galactosidase.J Gen Microbiol 1991 Apr;137 ( Pt 4):757-64PubMed: 1649890PMID: 1649890Ferretti JJ, Huang TT, Russell RSequence analysis of the glucosyltransferase A gene (gtfA) from Streptococcus mutans Ingbritt.Infect Immun 1988 Jun;56(6):1585-8 PubMed: 2967248PMID: 2967248Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","","Tue Apr 24 10:46:42 2007","","1","","","SMU.1571","" "SMu1429","1499312","1498053","1260","ATGAGAAAAATTGTCATTAATGGTGGTAAGCCCTTAAAGGGGGAGGTTGCGGTCTCAGGAGCTAAAAACAGTGTTGTCGCTCTGATTCCAGCTATTATTTTAGCAGATGATATTGTCACACTTGATGGTGTGCCAGCTATCAGTGATGTTGATAGTTTAATTGACATTATGACTTTAATGGGAGCAAGTGTTGAGTGTGATGGTGACAGTCTTAAAATTGATCCACGCGGTGTAAAGGATATTCCCATGCCTTATGGCAAGATTAATAGTTTAAGAGCTTCATATTATTTTTACAGTAGTTTGCTGGGACGTTTTGGTCGGGCGGTCGTTGGTTTGCCCGGTGGCTGCGATTTGGGACCTCGTCCGATTGATTTGCATCTCAAGGCCTTTAAAGCAATGGGAGCAACGGTTTCCTATGAAGGAGAGGCTATGCGCCTTTCAACCGAAGGCAAGCCGCTTAAGGGGGCTCATATTTATATGGATACTGTCAGTGTTGGAGCAACGATTAATACGATGATAGCTGCTAGTAAGGCACAAGGACGTACCGTTATTGAGAATGCTGCGCGTGAGCCAGAAATTATTGATATTGCAACGCTTTTAAATAATATGGGAGCCCATATCCGCGGGGCAGGAACGGATATGATTATCATAGAAGGTGTTGAAAAACTTCATGGAACGCGTCATCAAGTCATTCCTGACCGCATTGAAGCTGGTTCTTACATTGCTTTGGCAGCTGCTGTTGGTGAAGGAATCAAGGTTACCAATGTGCTTTATGAACATTTGGAGAGTTTCATTTCAAAGCTGGAAGAAATGGGCGTGCGTATGACTATTGAAGAAGACAGTGTTTTTGTTGAAAAGCAGGACAAATTAAAGGCAGTTTCCATTAAGACTTCGCCTTATCCCGGTTTTGCGACTGATCTGCAGCAGCCCATAACACCGCTATTATTAACAGCTGTAGGCCGCGGAAAGATTCGTGATACTATCTATGAAAAACGGGTCAATCATGTGGCTGAATTGGCACGTATGGGAGCTAAGATTTCTGTCTTAGGCGGTCAAATTATCTATGAAGGACCCAATGAATTAAGTGGAGCTCCTGTTAAAGCAACCGATTTACGTGCGGGAGCAGCACTTGTTACGGCAGGATTAATGGCAAAAGGTCAAACGGTTATTACGAATATTGAATTTATCTTGCGCGGTTATTCTGACATTATTCAAAAATTGAATCGTCTAGGTGCGGATATCGAAATTGTTGAAGAATAA","6.20","-3.38","44705","MRKIVINGGKPLKGEVAVSGAKNSVVALIPAIILADDIVTLDGVPAISDVDSLIDIMTLMGASVECDGDSLKIDPRGVKDIPMPYGKINSLRASYYFYSSLLGRFGRAVVGLPGGCDLGPRPIDLHLKAFKAMGATVSYEGEAMRLSTEGKPLKGAHIYMDTVSVGATINTMIAASKAQGRTVIENAAREPEIIDIATLLNNMGAHIRGAGTDMIIIEGVEKLHGTRHQVIPDRIEAGSYIALAAAVGEGIKVTNVLYEHLESFISKLEEMGVRMTIEEDSVFVEKQDKLKAVSIKTSPYPGFATDLQQPITPLLLTAVGRGKIRDTIYEKRVNHVAELARMGAKISVLGGQIIYEGPNELSGAPVKATDLRAGAALVTAGLMAKGQTVITNIEFILRGYSDIIQKLNRLGADIEIVEE","1498068","For other 'mur' genes see SMu0549 (murF); SMu0653 (murN); SMu0654 (murM); SMu0883 (murB); SMu1529 (murE); SMu1566 (murI);SMu0498 (murD); SMu0499 (murG); SMu1577 (murC);SMu1304 (murC) and SMu1386 (murA).","UDP-N-acetylglucosamine 1-carboxyvinyltransferase","Cytoplasm","Several matches in gapped BLAST to UDP-N-acetylglucosamine 1-carboxyvinyltransferase: residues 1-419 are 78% similar to theenzyme in S.pyogenes (gi|15675291|) and are 74% similar to the protein from S.pneumoniae (gi|15900950|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0843 (0.0).","

InterPro
IPR001986
Domain

3-phosphoshikimate 1-carboxyvinyltransferase
PD001867	$\"[12-412]T$	EPSP_synth
G3DSA:3.65.10.10	$\"[21-230]T$	EPSP_synthase
PF00275	$\"[6-407]T$	EPSP_synthase

InterPro
IPR005750
Family

UDP-N-acetylglucosamine 1-carboxyvinyltransferase
PTHR21090:SF4	$\"[72-417]T$	AcGlu_Tran_MurA
TIGR01072	$\"[1-416]T$	murA

InterPro
IPR013792
Domain

RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
SSF55205	$\"[1-419]T$	RNA3'_cycl/enolpyr_transf_A/B

noIPR
unintegrated

unintegrated
PTHR21090	$\"[72-417]T$	PTHR21090

","BeTs to 11 clades of COG0766COG name: UDP-N-acetylglucosamine enolpyruvyl transferaseFunctional Class: MThe phylogenetic pattern of COG0766 is -----qvceBrhuj--olinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 256-332 are 72% similar to a (TRANSFERASE UDP-N-ACETYLGLUCOSAMINE CELL) protein domain (PD413614) which is seen in MUA1_LACLA.Residues 335-390 are 71% similar to a (TRANSFERASE UDP-N-ACETYLGLUCOSAMINE CELL) protein domain (PD332044) which is seen in MUA1_LACLA.Residues 11-388 are 52% similar to a (TRANSFERASE SYNTHASE 1-CARBOXYVINYLTRANSFERASE) protein domain (PD001867) which is seen in Q9K6E5_BACHD.Residues 1-120 are 58% similar to a (TRANSFERASE UDP-N-ACETYLGLUCOSAMINE CELL) protein domain (PD404695) which is seen in MUA1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:55:49 2002","Thu Mar 14 11:06:57 2002","Thu Oct 17 14:55:49 2002","Thu Mar 14 11:06:57 2002","","Thu Mar 14 11:06:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1429 is paralogously related (blast p-value < 1e-3) to SMu1386,a predicted UDP-N-acetylglucosamine 1-carboxyvinyltransferase and SMu0711, a predicted 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase).","Thu Mar 14 11:10:45 2002","Thu Mar 14 11:06:57 2002","pdb|1UAE| Structure Of Udp-N-Acetylglucosamine Enolpyruvyl Tr... 334 1e-092pdb|1A2N| Structure Of The C115a Mutant Of Mura Complexed Wi... 330 2e-091pdb|1NAW|A Chain A, Enolpyruvyl Transferase >gi|2392465|pdb|1NA... 329 5e-091","SMU.1572c","","Residues 8 to 407 (E-value = 7.1e-98) place SMu1429 in the EPSP_synthase family which is described as EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (PF00275)","Thu Mar 14 11:06:57 2002","","","","Marquardt,J.L., Siegele,D.A., Kolter,R. and Walsh,C.T.Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferaseJ. Bacteriol. 174 (17), 5748-5752 (1992)PubMed: 1512209","","Thu Mar 14 11:08:50 2002","1","","","SMU.1572c","93" "SMu1430","1500649","1499456","1194","ATGTCAGAACGTAAACTTTTTACATCTGAATCGGTATCAGAAGGACATCCTGATAAGATTGCCGATCAGATTTCAGATGCTATTTTAGATGCTGTTTTGGTACAGGATCCAGACGCCCATGTAGCTGCTGAGACAGCTGTTTATACAGGTTCAGTTCATGTTTTTGGAGAAATCTCTACGACAGCCTATGTGGATATTAATCGTGTGGTGCGTGATACCATTGCTGAGATCGGCTATACGGATACTGCTTATGGCTTTTCGGCAGAAACAGTTGGAGTGCATCCGTCATTGGTGGAGCAATCGCCTGATATTGCTCAAGGTGTTAATGAAGCTCTTGAGGTTCGTGGCCATCATGAGCAAGATGATCTGGATTTGATCGGTGCAGGAGATCAAGGTCTCATGTTTGGCTTTGCCGTTGATGAGACGCCTGAACTGATGCCTTTGCCGATTTCTTTAGCCCATCGTTTGGTTAGAAAATTGGCAGAGCTGAGAAAGTCTGGAGAAATTGCCTATCTTCGTCCTGATGCTAAGAGTCAGGTAACGGTTGAGTATGATGAAAATGATAAGCCCGTTCGTGTGGATACGGTTGTTATTTCAACACAGCATGATCCCGAAGCAACGAATGAGCAAATTCATCGGGATGTGATTGAAAAAGTCATTAAAGCTGTTATTCCAGCTGAGTATCTTGATGCTAAGACCAAGTATCTCATCAATCCGACAGGCCGTTTTGTTATCGGCGGTCCTCAGGGAGATTCTGGCTTAACAGGCCGTAAGATTATTGTCGATACTTATGGTGGTTATGCCCGCCATGGCGGCGGTGCTTTTTCTGGTAAGGATGCCACTAAGGTTGACCGTTCAGCTTCTTATGCGGCGCGTTATATTGCTAAAAACATTGTAGCTGCAGGTTTGGCTAAGAAAGCAGAAGTGCAATTAGCTTATGCTATTGGGGTTGCTCAGCCTGTTTCTGTTCGTGTGGATACCTTTGGAACAGCGCTTGTTGCAGAAAGTAAACTGGAACAAGCAGTACGTCAGATTTTTGATTTGCGTCCAGCAGGTATTATTAAGATGCTTGATCTGAAACGTCCTATCTATCGTCAAACAGCAGCTTACGGTCATGTTGGGCGTACGGATATCGACTTACCTTGGGAAAAATTAGATAAAGTTGAGGAGCTGAAAAAGGCTGTCCAAGCATAA","5.20","-12.32","43116","MSERKLFTSESVSEGHPDKIADQISDAILDAVLVQDPDAHVAAETAVYTGSVHVFGEISTTAYVDINRVVRDTIAEIGYTDTAYGFSAETVGVHPSLVEQSPDIAQGVNEALEVRGHHEQDDLDLIGAGDQGLMFGFAVDETPELMPLPISLAHRLVRKLAELRKSGEIAYLRPDAKSQVTVEYDENDKPVRVDTVVISTQHDPEATNEQIHRDVIEKVIKAVIPAEYLDAKTKYLINPTGRFVIGGPQGDSGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQLAYAIGVAQPVSVRVDTFGTALVAESKLEQAVRQIFDLRPAGIIKMLDLKRPIYRQTAAYGHVGRTDIDLPWEKLDKVEELKKAVQA","1499471","For other 'met' genes see SMu0796 (metE),(metC);SMu1527 (metB); SMu1492 (metS) and SMu1335 (metA).","S-adenosylmethionine synthetase","Cytoplasm","Several matches in gapped BLAST to S-adenosylmethionine synthetase: residues 1-396 are 89% similar to the enzyme in S.pneumoniae (gi|15902715|) and are 85% similar to the protein from S.pyogenes (gi|13622468|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0831 (0.0).","

InterPro
IPR002133
Family

S-adenosylmethionine synthetase
PIRSF000497	$\"[3-396]T$	MAT
PTHR11964	$\"[1-394]T$	S-AdoMet_synt
PF00438	$\"[3-102]T$	S-AdoMet_synt_N
PF02772	$\"[124-243]T$	S-AdoMet_synt_M
PF02773	$\"[245-384]T$	S-AdoMet_synt_C
TIGR01034	$\"[6-395]T$	metK
PS00376	$\"[127-137]T$	ADOMET_SYNTHETASE_1
PS00377	$\"[271-279]T$	ADOMET_SYNTHETASE_2

noIPR
unintegrated

unintegrated
G3DSA:3.30.300.10	$\"[12-167]T$ $\"[256-393]T$	G3DSA:3.30.300.10
SSF55973	$\"[3-104]T$ $\"[120-244]T$ $\"[245-396]T$	SSF55973

","BeTs to 11 clades of COG0192COG name: S-adenosylmethionine synthetaseFunctional Class: HThe phylogenetic pattern of COG0192 is ----Yqvcebrhujgpol---Number of proteins in this genome belonging to this COG is 1","***** IPB002133 (S-adenosylmethionine synthetase) with a combined E-value of 1.6e-200. IPB002133A 5-49 IPB002133B 77-109 IPB002133C 124-154 IPB002133D 174-225 IPB002133E 251-287 IPB002133F 288-325 IPB002133G 326-375 IPB002133A 17-61","Residues 4-383 are 77% similar to a (SYNTHETASE S-ADENOSYLMETHIONINE TRANSFERASE) protein domain (PD001322) which is seen in METK_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 08:18:54 2002","Thu Mar 14 11:14:45 2002","Thu Oct 17 14:54:45 2002","Thu Mar 14 11:14:45 2002","Thu Mar 14 11:14:45 2002","Thu Mar 14 11:14:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1430 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 11:15:49 2002","Thu Mar 14 11:14:45 2002","pdb|1FUG|A Chain A, S-Adenosylmethionine Synthetase >gi|1827908... 465 5e-132pdb|1XRB| S-Adenosylmethionine Synthetase (Mat, Atp: L-Methi... 457 1e-129pdb|1QM4|A Chain A, Methionine Adenosyltransferase Complexed Wi... 428 5e-121","SMU.1573c","","Residues 3 to 103 (E-value = 2.5e-48) place SMu1430 in the S-AdoMet_synt_N family which is described as S-adenosylmethionine synthetase, N-terminal domain (PF00438)Residues 124 to 243 (E-value = 3.5e-83) place SMu1430 in the S-AdoMet_synt_M family which is described as S-adenosylmethionine synthetase, central domain (PF02772)Residues 245 to 384 (E-value = 1.8e-81) place SMu1430 in the S-AdoMet_synt_C family which is described as S-adenosylmethionine synthetase, C-terminal domain (PF02773)","Thu Mar 14 11:14:45 2002","","","","Yocum,R.R., Perkins,J.B., Howitt,C.L. and Pero,J.Cloning and characterization of the metE gene encodingS-adenosylmethionine synthetase from Bacillus subtilisJ. Bacteriol. 178 (15), 4604-4610 (1996)PubMed: 8755891","","Thu Mar 14 11:15:49 2002","1","","","SMU.1573c","92" "SMu1431","1502491","1501433","1059","ATGATTGGGGACTTTTGGAAAGAATCCAATGGACTTGCTACAGCTAATGATATGGATAAAAACCTTGCTTATATGTATACCATGAAGAAAAAAGCTCGTGGCCAATTGTTATTTACAAAGGAAAAGTTAGCTGAATATGGTTCAAAGGTGGGACTTTTTCCTGGTGTAAAGGATTGGTTTAGACGTATCAGACAATATGGAGCGGATAGAGAAGTTATCATTGAGCATTATATTATTTCATCTGGATTGAAAGAGATGATAGAGGGAACATCTATTGCAAAAGACTTCAAGGAAATATACGCAACATCTTTTTACTTTGATGATGATGGTGTAGCAGTATGGCCTGCCCAAGTGGTTAACTATACCAATAAGACACAGTTTCTTTTTCGTATTTCAAAAGGTGTTTTAAATGTAAATGATGAAGCTGTTAATGATTCTTTTGCTCCAGACGAAATTAGAGTCCCTTTTCATAATATGATTTATATTGGTGATAGTGATACTGATATTCCTTGTATGAAATTAGTAAATTCTCATGGTGGATATTCTATTGGTGTTTTTAACCCTAAGGAAAGAAATGAAGAAAAAGCTAAGAAGAGAGTTTACAAAATGATACGAGATAATCGTATTGGCTATTTTACTCCAGCTGATTATTCGGAAGGCCAAGAATTAGATCAGCTTGTTAAGTTGATTATTGACAGAACAGTATTTAATGAGCAATTGGAAAGAAAGCACTATGAGTATAAAAATGAGGCGCTGAAACAATCTAAACAAAAGAGTGAGGAAGAACAAGAGAAAATCGATTTGATTGATGCTCTAGAAAGTAGTGGTAATTTTAAAAATACCCATAATATCATCAGAAAACTATCAAAATACGAGAATTGGCAGGATGATGAAATCATAGATTTGCTCTCTATAGGTTTTCATAACAGTCAAGTACGTTATATTTTAGGTGATCAAGATATTAAAGTATTTTACAAAAAAATTTTAGAAAAAGCTCCTTCGATTGATGAAAATGCAGCGAAAGTAGCAGCTATTATTGAAGCATCAGAAGAGGAATAA","5.30","-7.56","40711","MIGDFWKESNGLATANDMDKNLAYMYTMKKKARGQLLFTKEKLAEYGSKVGLFPGVKDWFRRIRQYGADREVIIEHYIISSGLKEMIEGTSIAKDFKEIYATSFYFDDDGVAVWPAQVVNYTNKTQFLFRISKGVLNVNDEAVNDSFAPDEIRVPFHNMIYIGDSDTDIPCMKLVNSHGGYSIGVFNPKERNEEKAKKRVYKMIRDNRIGYFTPADYSEGQELDQLVKLIIDRTVFNEQLERKHYEYKNEALKQSKQKSEEEQEKIDLIDALESSGNFKNTHNIIRKLSKYENWQDDEIIDLLSIGFHNSQVRYILGDQDIKVFYKKILEKAPSIDENAAKVAAIIEASEEE","1501448","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST only to a hypothetical protein:residues 5-223 are 26% similar to gi|3915318| as seen in Borrelia burgdorferiSMu1431 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PD126737	$\"[5-225]T$	PD126737
SSF56784	$\"[52-197]T$	SSF56784

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-223 are 26% similar to a (BB0007) protein domain (PD126737) which is seen in Y007_BORBU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:27:04 2002","Thu Mar 14 11:18:22 2002","Thu Mar 14 11:18:22 2002","Thu Mar 14 11:18:22 2002","","Thu Mar 14 11:18:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1431 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:27:04 2002","","No significant hits to the NCBI PDB database.","SMU.1574c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 11:18:22 2002","24379958","","","","","","1","","","SMU.1574c","" "SMu1432","1503105","1502821","285","ATGGAAGTCTTAAAAATTGAAGGGAATAATTGTTTCTTTATTGTAGATGCAGAAAATATCAAGCCTGAGGATTTATCAAAAGAACATTTAGTCTCTATATTAAATTTAATTTACGAAACAGATGATGAGATTGAAATTCCTTCACTTGAAATTATTGAGAAAATAAAGAATCCTGTTGAAAAAGAAATCGTTCATCAAATTATCCAAAAAATAGAAGAATTTAAGGAAAATGTTGAAAACCTACGAAAGGAAATAAATTCCCAGTTTCCAAAAATAGAAGAATAA","4.30","-11.56","11074","MEVLKIEGNNCFFIVDAENIKPEDLSKEHLVSILNLIYETDDEIEIPSLEIIEKIKNPVEKEIVHQIIQKIEEFKENVENLRKEINSQFPKIEE","1502836","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1432 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:26:40 2002","Thu Mar 14 11:19:25 2002","Wed Oct 9 08:26:40 2002","Thu Mar 14 11:19:25 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1432 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:26:40 2002","","No significant hits to the NCBI PDB database.","SMU.1575c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 11:19:25 2002","24379959","","","","","","1","","","SMU.1575c","" "SMu1433","1505134","1503086","2049","ATGGTTAAAAAAATAGATTTTCATATTCATACTATTTCATCAATTAAAGATGCTAATTTTGTATATTCATCAAAATGGTTAGCTAAATATGTTGAAACTGCTGAATTAGATGCTATAGCTATTACCAATCATGATTTATTCGATAAAAATAATTATGAACAGGTAAAATCAGATATTTCAAATGTAAAAGTTTTTCCAGGTATGGAACTAACGCTTGATGTTGGGCATGTTAATATTGTTTTTTCTGAAAAACAGATAGATGATTTGGAAAAATTTTCAAATTGGTTAAAACAAAGACATACCAGTCAAAATGAAAGTATCACATGTGAGGAACTGTGTCAGAATTTAAATAATTGGGATAAAGGAATATATATATTTGAATTAGGAAAAAGTAATGGCGTAACAGATATTCCAGAAGCATTGAGTAAAGTAACATATGTTGGTGGAGTCCGAAATTCGTTAAGGTTTCAGGTTGTTCAAAAACAGGGGAATAGCTTAACACCAGTTCTTTTTAGTGATGGTCATGCTACCGATAAAGATAGTCAACCTGATAGAAATAATATAAATAAATTGAAAAATAAAAATACTTATATTCAAGTGGATACCTGTAATTTCTCTGAGATTAAGAATTGTATTTCAGATAAAACAAAAGTCAGTATTACTAAAGATAATCTGCAGGATGTTATAGAGATAGATGGTTACAAATTGTCAACAGGTTTAAACCTAGTTGTCGGAAAAAGAGGGACAGGGAAAACTTATTTTTTAAATAAAATCAAAGAACAATTTGACCAAGATGATATATATGAAATTGCACAATTTGAAACTGCTAAGGCTGATGATTACATGAAAAGGACTAAAAAAGAACAAGGTCAGAATGCTATTAATGAATGGAATAATAAATTTAGTCGACAATTTGCATCAATTAATGAATATCTTGAGATAGTCGATGAAGACTACGATGATGAACTTGATTCATTCTTAGATAGTGTTAAAAAATTTGCTAAAGAAACAACAAAAAGTAAATCACAACAGAAATTTAATTTTTTCAAAGAGGTTAATTTTGAAAAGCAACCTACTAAACTTATTGAAGAGTCGCTGACTAAATTAAAAGAATTAATAGAAAATAATGAGTTGTGGTCTCTATTGAAAGACTCTAATAAAAGACGATTAGTTTTTATTTCGACTTACAATGAGTTAAGAGATATTTATATTGAAAAAGAAAAACAAAACAAAATAAAAGACGAAGTAAATAAAATATTAGATTCTGCAAAAGAAATCTTAGAATCAAATACAGGAATAACAAGGGTACGAAGCTGTGAACTAAGTAGAATAGTGAAACGCCAACAAATTGAAAATAAGATTACCGAATTTCTGCAAAAGGTAATTGTCGAAACAGATTTAAGAAAAGAAAATATACATGGTTACCAAGTAATTGTACAGTTAGTCCCATTCGAGAGTGCAAGTCAATTCCAATCTGAATTTTCAATGAATGAAAGTGTTAAAGAAGATATCATTAATCCATATTTGTCAAGTGATTACATTACATTTCTAAAAAAACTTAAGAATAAAAAATTTTATAACAATTCAAACTTAGTAGAGTATTTTATGCATAAAGAGGTAAAACTTTTAGATTCTGATGGAACTCCAGCTTCTGGGGGGCAGGCGGTAGGTTTTACCCTTATGATGAGGTTAGATGAAGCTAAAAACAAGTCAATTATCTTAATTGATGAACCAGAGGCTTCACTGGATAATGCCTATATCCAAACAGAATTGAATCAATCATTAAGAAATTTATCGAGTGCTAGTATGGTGGTAGTTGTTACTCACAATTCGACTCTTGGAGCACTATTGCAACCTGATTATTTAGTAGTTACTACAAAAAATGATAATGGGGAATATACTGTTTTAACAGGAGAGTTTAGTTCACATGTCGTTTCCGATAATTCAGATTTATCAGAAAATAGTTATGAAAAATTTGTAGAAGCTATGGAATCAGGAATTAAATCATATAAGCAGAAAGGTGAAGTATATGGAAGTCTTAAAAATTGA","5.30","-13.74","78277","MVKKIDFHIHTISSIKDANFVYSSKWLAKYVETAELDAIAITNHDLFDKNNYEQVKSDISNVKVFPGMELTLDVGHVNIVFSEKQIDDLEKFSNWLKQRHTSQNESITCEELCQNLNNWDKGIYIFELGKSNGVTDIPEALSKVTYVGGVRNSLRFQVVQKQGNSLTPVLFSDGHATDKDSQPDRNNINKLKNKNTYIQVDTCNFSEIKNCISDKTKVSITKDNLQDVIEIDGYKLSTGLNLVVGKRGTGKTYFLNKIKEQFDQDDIYEIAQFETAKADDYMKRTKKEQGQNAINEWNNKFSRQFASINEYLEIVDEDYDDELDSFLDSVKKFAKETTKSKSQQKFNFFKEVNFEKQPTKLIEESLTKLKELIENNELWSLLKDSNKRRLVFISTYNELRDIYIEKEKQNKIKDEVNKILDSAKEILESNTGITRVRSCELSRIVKRQQIENKITEFLQKVIVETDLRKENIHGYQVIVQLVPFESASQFQSEFSMNESVKEDIINPYLSSDYITFLKKLKNKKFYNNSNLVEYFMHKEVKLLDSDGTPASGGQAVGFTLMMRLDEAKNKSIILIDEPEASLDNAYIQTELNQSLRNLSSASMVVVVTHNSTLGALLQPDYLVVTTKNDNGEYTVLTGEFSSHVVSDNSDLSENSYEKFVEAMESGIKSYKQKGEVYGSLKN","1503101","","hypothetical protein","Cytoplasm, Membrane","Limited weak matches in gapped BLAST to hypotheticals:residues 560-677 are 24% similar to gi|15902998| as seen in S.pneumoniae and residues 180-513 are 23% similar to Plasmodium falciparum gi|16804938|SMu1433 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[237-629]T$	AAA

noIPR
unintegrated

unintegrated
SSF52540	$\"[229-642]T$	SSF52540
SSF89550	$\"[3-90]T$	SSF89550

","BeTs to 4 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 11:24:54 2002","Thu May 2 12:25:23 2002","Thu Mar 14 11:24:54 2002","Thu Mar 14 11:24:30 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1433 is paralogously related (blast p-value < 1e-3) to SMu1037, a predicted phosphate ABC transporter, ATP-binding protein.","Thu Mar 14 11:24:54 2002","","No significant hits to the NCBI PDB database.","SMU.1576c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 11:24:30 2002","24379960","","","","","","1","","","SMU.1576c","" "SMu1434","1508940","1505191","3750","ATGACTCAAATTTTTAAAAAGTTAACTCCCATAAATGATGCAGATATTGAACAAGCACATATTGATGCTATTAATTTTGCAATTGAAGATAAAGATGTTTTAAATGTTGCTGTATCTGGTAATTATGGTTCAGGTAAGAGTAGCTTTATTGAGACATATAAAGAAAAGTTCAATAATAAAAAGAAGAAGTTTCTACATGTTTCTTTAGCTCATTTCAATTCTGAAGATGGAAATACAGAGAGACAGCAGAGTAATTCTGGGACAGATAAAGCAGCTCCAAAAGATAATATTTTGGAAGGAAAAATAGTTAATCAATTACTTCATCAGATTGATGCTGATAAAATCCCTCTAACTATTTTTAAGTCAAAACAACATCCCAAGAAGAGACAAATTTTGGGATGGTTTATTCTACTGACTATTTTGATACTTTCAATGCTAGCTTTATGGACCTTTCCAAACTTATCTTGGGACAGTTGGATTAAGCAGGTATTAGTTATCCTTTTAATCATAAGTATTTCAGTATTGATTTACCAACTAATGAAACTTCAGTTTTATCGTAAACTATTTAAATCAATAACTTTCAAAGGTGCTTCTGTCTCGGGAGAGATTGAGATATTTGGCAAGTCTGATGCTTCATATTTTGATAAATATCTGGATGATGTTCTTTATTTATTTGATAACTGTCAAAGTGATATTATTGTTTTCGAGGATATCGATAGATTTGAGACTAATCTGATTTTTTCAAAACTTAAAGAAATTAATACTCTAGTAAATAATAAAAGAAAGGCTAGAGGTGAAGATAATAAACTCCTCTTTATGTACCTTGTTAAAGATGAGATGTTCATTTCTAAAGAGCGGACTAAATTTTTTGATTTTATCATTCCGGTTATTCCAGCGATTACAGCATCAAATTCAAGGGAAAAATTCAGTGAAATACTAGCTGATTTAGGGTGTGAAGAAGATTTTGAAGGTAGTTTTTTGCAGAAAATTTCAATCTATATTGATGACTTACGTCTAGTAACCAATATCTGCAATGAATATGTACTATATAAAAATAATCTAACGGGAGAAGAGAGTGCAAATAAACTTAAACTATCAAACGAAAAGCTATTTGCAATGATAGTTTACAAAAATGTTTTCCCAAAAGATTTTTCTGAACTGCAAGTCGGGTCTGGATTTATTCATAGATTTTTTCAAGAGAAAGATAAGCTTAGGGAAGAACAGCTACATGATATAAATCAACAGATTTCAGAAATTGAACAGAAGATTTTAAGTGCAGGAAATGAAGCACTAAACAATGAATTGGAATTATATTCTTCAATTTTAAAAGTTCCCAATAATCGTGCTGTTTTAAAAGTTAACAATAAATTTGAATACGAATTTGAAAATCGACTTGGTTTTATCGCTGAGTTGCTAAAGGAGGATGCCGAAATAGTGTCTTATGAAAATTACTCTTCTGCTTATAGTGGTTATAATGTAAGAAATGAGACAAAGGAAACGATTTTTGAGATTCTAGACTCTGAACAGGCTAATTTTGAATCTCGACTAGAAAATATAAAAAATAAGAGTTTGATCGAATCATTTAATAATGAGATAGATGCTTTTCAGAAGAAAAAACAAGAAATTCAACACCAAAAATTAGCAAATTTAATTACACGAGAAAAAATAAATAGCATTGCTAATGAAGAGGAGTTTGAATACATAAAATATAATCCTCAGTTTTCCATGATTACATTTTTAATCAGGAATGGTCATATTGATGAAAGTTACCCTGACTATATCACTTATTTCTATCCAAATAGCTTGAACAGAGAGGACAAAGAATTTATCATGGCTGTTCAAGGTGAAGAGAAACTTCCTTGGGATTATCATCTAACAAATATTACAGAAATTTATAATAATAGATTAGATACAAGTGATTTTGAACAAGAAAAGATTTTAAATTACAGTCTTTTAGAATACACAATGACAAGAAAGGGAATTTTAGATCAAGAAGAAAGATTAAGACTTTATTTTGTTGAAAATAGATTATCGTTTCTTCTTTCTTTCTTCCAGCAAGTTCCTATTGAAGGTCAGATAAATACTGTTTTGGATATTTTAAAGTATAATCCCAACCTTTTGGAATTATTAGTAGTATCCGATGATATTCTTGATAAAGATAGGTATGCTGTATTTCAACGGATATTGTTTTTTGTTGATTTAACACAAGAGATCTTGTCTGACAAATATCAAAAATTAGTTTCTGATTTTATCTCTCATAATTGGTTGCAACTTTGGGAAGAGTATCTGTCTACAGAATTAAGAGATGAGATGAAAGTCAAAAGGAATTTAACTTATCTTACTGTTAAAATTGATAGGTTTGATTTTATACAGGAACAAGAATATGGTTCGATAGGTAAAACTGTGTATGAGAACAGCCTCTATCAACTAAACTCTAGTAATATCAAGAATTTGTTGTTATATTTAGATTATAATCTTGACAATGATGATATTAAACATCGAAACTTTAGTATTATCAACTCTGACAACAAATTCGCTCATTTGCTGGATTATGTCAAAGAAAATATGGGAGACTATGTTAAAGTTATTGTTGAACAGTCCGAAGGTGAAATTAAGGATAAGTTAGAGTATATTTATTATGTTCTTAATCATGAAGACATTTCAGATGAGACTAAAACAAAGTACTTGACTTGTGTTGATGACAATATTTTATCTTTATCAGAAATTGATGATATGCCAATGACTGATGAGGCTATTAAGCTTAATAAAGCAGTCTTTGATACTAAAAATGTACTAAACTACTTTGCCAAATATGGTACATGGAATGAACTTTTGATAAACTTCGTTAATTCTAAAGATAATTTCAACTTTGATAATAAAATTTTTGAAGAAGAATCAAAAGAGGAACAAGAAAAGTTTTTCTTAGAAACTGCTAAGTGTAGTGAATTAAATAATAATTATTATGAAGCTATTATGTCATCTATTAGTTGGAAATTTACTGTTTTTCCGACTGAAAAGATTAGTGACAAAAAAATAGATATACTCATTGAAACTAAGTCAATTGAATTTAGCAGCGCTATACTTTCAAATTTAAGAGATAGTTATCCTGCAAGTGTTATTAAATATATTCTAAAATATTTGGATGACTATAGTGATAACATAGATAATGTCTATAATGAAAACGAAATTTTAGAAGTTTTGGATCAGGATATTCCACTTGAAAAAGCCAAAATATTAGTTGACAAGTTTAATAGCACTATCAGTATAAAGGATAAAAAATACAATTCAGCATTGCTAGCCTATATCATTGAAAATAAATTTAATGTTGAAGATTTACCAATGCTTCTGGAGAAGTATCAAATCTTCGATACTACCGTTCAGGAAGTTATTTTACAGAAAGCAAAATCAGATATAGAAATTATTTTGGACAATGCATATCCTATAGATAAAAATTTACTTTCATTGTTAATAAAAGATGATGATATTGATTTAGATGATAGACGTCTGCTTTACAGTAGGAATATTCCACATGATAGTGTAGAAGAAGTGCTGGAAGATTTGTGTTTCCTTAGTTTATTTGAAGAGTATCAGCAAATAATAAGTGAACATAGAAGTATAAATGTTCCTGCTACTGAATATAATCAAAATTTACTTAAATTCTTGCAGGATAAAGAATGTTTTAAATCATTTGATATAGATCCAAATGATGAGGAAAATTATAAGATTGGTTTTAAAGAGAAATTGAAGTAA","4.60","-63.25","146793","MTQIFKKLTPINDADIEQAHIDAINFAIEDKDVLNVAVSGNYGSGKSSFIETYKEKFNNKKKKFLHVSLAHFNSEDGNTERQQSNSGTDKAAPKDNILEGKIVNQLLHQIDADKIPLTIFKSKQHPKKRQILGWFILLTILILSMLALWTFPNLSWDSWIKQVLVILLIISISVLIYQLMKLQFYRKLFKSITFKGASVSGEIEIFGKSDASYFDKYLDDVLYLFDNCQSDIIVFEDIDRFETNLIFSKLKEINTLVNNKRKARGEDNKLLFMYLVKDEMFISKERTKFFDFIIPVIPAITASNSREKFSEILADLGCEEDFEGSFLQKISIYIDDLRLVTNICNEYVLYKNNLTGEESANKLKLSNEKLFAMIVYKNVFPKDFSELQVGSGFIHRFFQEKDKLREEQLHDINQQISEIEQKILSAGNEALNNELELYSSILKVPNNRAVLKVNNKFEYEFENRLGFIAELLKEDAEIVSYENYSSAYSGYNVRNETKETIFEILDSEQANFESRLENIKNKSLIESFNNEIDAFQKKKQEIQHQKLANLITREKINSIANEEEFEYIKYNPQFSMITFLIRNGHIDESYPDYITYFYPNSLNREDKEFIMAVQGEEKLPWDYHLTNITEIYNNRLDTSDFEQEKILNYSLLEYTMTRKGILDQEERLRLYFVENRLSFLLSFFQQVPIEGQINTVLDILKYNPNLLELLVVSDDILDKDRYAVFQRILFFVDLTQEILSDKYQKLVSDFISHNWLQLWEEYLSTELRDEMKVKRNLTYLTVKIDRFDFIQEQEYGSIGKTVYENSLYQLNSSNIKNLLLYLDYNLDNDDIKHRNFSIINSDNKFAHLLDYVKENMGDYVKVIVEQSEGEIKDKLEYIYYVLNHEDISDETKTKYLTCVDDNILSLSEIDDMPMTDEAIKLNKAVFDTKNVLNYFAKYGTWNELLINFVNSKDNFNFDNKIFEEESKEEQEKFFLETAKCSELNNNYYEAIMSSISWKFTVFPTEKISDKKIDILIETKSIEFSSAILSNLRDSYPASVIKYILKYLDDYSDNIDNVYNENEILEVLDQDIPLEKAKILVDKFNSTISIKDKKYNSALLAYIIENKFNVEDLPMLLEKYQIFDTTVQEVILQKAKSDIEIILDNAYPIDKNLLSLLIKDDDIDLDDRRLLYSRNIPHDSVEEVLEDLCFLSLFEEYQQIISEHRSINVPATEYNQNLLKFLQDKECFKSFDIDPNDEENYKIGFKEKLK","1505206","","conserved hypothetical protein","Cytoplasm, Membrane, Extracellular","Matches in gapped BLAST only to a hypothetical protein: residues 4-1247 are 25% similar to gi|7475217| from B.subtilisSMu1434 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[130-152]?$ $\"[158-180]?$ $\"[289-304]?$	transmembrane_regions

","BeTs to 5 clades of COG1196COG name: Chromosome segregation ATPasesFunctional Class: DThe phylogenetic pattern of COG1196 is am-kYqvc-br---gpol---Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 4-1247 are 25% similar to a (DNA-BINDING PROTEOME COMPLETE) protein domain (PD149017) which is seen in O34784_BACSU.Residues 405-565 are 28% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in Q25662_PLACH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:25:05 2002","Thu Mar 14 12:56:55 2002","Thu Mar 14 12:56:55 2002","Thu Mar 14 12:56:55 2002","","Thu Mar 14 12:56:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1434 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:25:05 2002","","No significant hits to the NCBI PDB database.","SMU.1577c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 12:56:55 2002","24379961","","","","","","1","","","SMU.1577c","" "SMu1435","1509217","1510152","936","ATGAAAACGTATGAGAAAATTTATCAGGTGCTTTCGCAGGCGGATGATTTTGTGACAGGTAAGGTTCTGGGTAAGGATTTGGGCATTTCTCGGACAGCTGTTTGGAAGGCGATTCAGACTTTAGAAAGTAAAGGGCTTGTCATTGAATCGGTTAAGAATCGTGGATATCGCTTGCTTTCGGGCGATCTTTTTTTACCGGATGAGATTGAACAGATGACTGGGATCAAGGTCTTTTTCAATGAGAAGAGTTCTTCGACACAGCTGGATGCTAAGGCAGGTATTGAAAAAGGGGACCCTGCTCCTGCTCTTTATCTTGCGCCTAGTCAGACAGCTGCTAAGGGGCGTTTTAGTCGGCAGTTTTTTACTCCTGAAACTGGAGGCATTTATATGTCTATACATCTTCACCCTGAATTGCCTTTTAAGCAGTTACCTTCTTATACTTTGATGGCTGCTACCAGTGTAGTTAAGGCCATTTCTCGCTTGACTGGGATTGAAACAGACATCAAGTGGGTCAATGATATTTATTTGCATGGTAAAAAGGTGGCTGGTATTTTGACCGAGGCTGTTTCTTCTATCGAGACAGGCTTGATTACCGATGTTATCATTGGTATGGGCATTAATTTTCATGTTACTGATTTTCCTGAGGAATTGCAGAGCAAGGCAAGCAGCATTTTTTCTGAAAAGCCTACTATCACGCGGAATCAGCTCATCTCTGAAATTTGGAATATTTTCTTTAATATTCCTAAGTCCGAACTGATAAAAGTCTACAAAGAAAAATCACTCGTCCTAGATAGACAAGTGACCTTTGTGGAAAATGATGTGACTTATAAGGGTATTGCGACAGATATTACAGATACGGGACAGCTCATCGTGCAATTAGAAAATGGGCAGGAAAAAATCCTTAACAGTGGCGAAATTAGTCTTTCTTCTTGGTAG","5.80","-3.02","34520","MKTYEKIYQVLSQADDFVTGKVLGKDLGISRTAVWKAIQTLESKGLVIESVKNRGYRLLSGDLFLPDEIEQMTGIKVFFNEKSSSTQLDAKAGIEKGDPAPALYLAPSQTAAKGRFSRQFFTPETGGIYMSIHLHPELPFKQLPSYTLMAATSVVKAISRLTGIETDIKWVNDIYLHGKKVAGILTEAVSSIETGLITDVIIGMGINFHVTDFPEELQSKASSIFSEKPTITRNQLISEIWNIFFNIPKSELIKVYKEKSLVLDRQVTFVENDVTYKGIATDITDTGQLIVQLENGQEKILNSGEISLSSW","1510161","","biotin--[acetyl-CoA-carboxylase] ligase","Cytoplasm","Several matches in gapped BLAST to biotin operon repressor: residues 1-311 are 63% similar to the protein in S.pyogenes (gi15675294) and are 54% similar to the protein from S.pneumoniae (gi15901727).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0830 (1e-111).","

InterPro
IPR003142
Domain

Biotin protein ligase, C-terminal
PF02237	$\"[262-309]T$	BPL_C

InterPro
IPR004143
Domain

Biotin/lipoate A/B protein ligase
PF03099	$\"[79-177]T$	BPL_LipA_LipB

InterPro
IPR004408
Domain

Biotin--acetyl-CoA-carboxylase ligase
TIGR00121	$\"[76-309]T$	birA_ligase

InterPro
IPR008988
Domain

Transcriptional repressor, C-terminal
SSF50037	$\"[262-309]T$	Transcr_rep_C

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-58]T$	Wing_hlx_DNA_bd

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[2-57]T$	HTH_11

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[61-247]T$	G3DSA:3.30.930.10
PTHR12835	$\"[49-302]T$	PTHR12835
SSF46785	$\"[1-61]T$	SSF46785
SSF55681	$\"[60-261]T$	SSF55681

","BeTs to 14 clades of COG0340COG name: Biotin-(acetyl-CoA carboxylase) ligaseFunctional Class: HThe phylogenetic pattern of COG0340 is amtkyqvcebrhuj---linxNumber of proteins in this genome belonging to this COG is 1","***** IPB003142 (Biotin protein ligase C terminal domain) with a combined E-value of 1.8e-08. IPB003142A 109-125 IPB003142B 168-177","Residues 82-308 are 45% similar to a (LIGASE BIOTIN PROTEOME COMPLETE) protein domain (PD004125) which is seen in Q9CED9_LACLA.Residues 7-76 are 38% similar to a (PROTEOME BIFUNCTIONAL BIRA COMPLETE) protein domain (PD391029) which is seen in Q9CEQ6_LACLA.Residues 10-57 are 45% similar to a (LIGASE BIOTIN OPERON REPRESSOR) protein domain (PD111175) which is seen in Q9KC88_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 13:00:03 2002","Tue Aug 29 17:12:06 2006","Tue Aug 29 17:09:49 2006","Thu Mar 14 12:59:37 2002","Thu Mar 14 12:59:37 2002","Thu Mar 14 12:59:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1435 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 13:00:03 2002","Tue Aug 29 17:09:49 2006","pdb1BIA Bira Bifunctional Protein (Acts As Biotin Operon Re... 92 6e-020","SMU.1578","","Residues 79 to 214 (E-value = 2.6e-12) place SMu1435 in the BPL_LipA_LipB family which is described as Biotin/lipoate A/B protein ligase family (PF03099)Residues 262 to 309 (E-value = 9.7e-11) place SMu1435 in the BPL_C family which is described as Biotin protein ligase C terminal domain (PF02237)","Tue Aug 29 17:09:49 2006","24379962","","","Bower,S., Perkins,J., Yocum,R.R., Serror,P., Sorokin,A., Rahaim,P.,Howitt,C.L., Prasad,N., Ehrlich,S.D. and Pero,J.Cloning and characterization of the Bacillus subtilis birA geneencoding a repressor of the biotin operonJ. Bacteriol. 177 (9), 2572-2575 (1995)PubMed: 7730294","","Thu Mar 14 13:01:05 2002","1","","","SMU.1578","548" "SMu1436","1510124","1510324","201","GTGGCGAAATTAGTCTTTCTTCTTGGTAGCCGACAAGATGGCTTTGGTAAACTTGCTGATAACATAAGTCTTATGCAGACTGCGAAAGAGCAAAATCCCCCAAAAACCAGCCCAAAAGAATTGACCTTCAAAAATCGCATTATTAAAAAAAATGGTTTCAGTCACAGTCGTTATCAGCATGATAATGAAGTCTTGTTTTAA","10.70","5.46","7515","MAKLVFLLGSRQDGFGKLADNISLMQTAKEQNPPKTSPKELTFKNRIIKKNGFSHSRYQHDNEVLF","1510333","","hypothetical protein","Periplasm, Cytoplasm","No significant hits in gapped BLAST found.SMu1436 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:24:34 2002","Thu Mar 14 13:02:02 2002","Wed Oct 9 08:24:34 2002","Thu Mar 14 13:02:02 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1436 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:24:34 2002","","No significant hits to the NCBI PDB database.","SMU.1579","","No significant hits to the Pfam 11.0 database","Thu Mar 14 13:02:02 2002","24379963","","","","","","1","","","SMU.1579","" "SMu1437","1512103","1510427","1677","ATGTACCAAGCGCTTTATCGAAAATATCGAAGTCAGACTTTTGATGAAATGGTAGGGCAGGAAGTTGTGGCAAAGACCTTAAAACAGGCTGTTGCTTCAAAGAAGATTAGTCATGCCTATCTTTTTTCTGGACCAAGGGGAACAGGAAAAACCAGTGCTGCTAAGATTTTCGCCAAAGCCATGAACTGTCCTCATCAAGCAGACGGGGAACCTTGCAATAACTGTGATATTTGCCATGATATTACCAACGGAAGTCTGGAAGATGTGATAGAAATTGATGCTGCTTCTAACAATGGTGTTGATGAGATCCGTGAAATTCGTGATAAGTCAACCTATGCTCCTAGCCGTGCCACTTACAAGGTTTATATCATTGACGAAGTACACATGCTCTCAACAGGGGCTTTCAATGCCCTTTTGAAAACTTTGGAAGAACCAACAGAAAATGTTGTCTTTATTTTGGCAACAACTGAATTACATAAAATTCCAGCTACTATCCTTTCACGTGTTCAACGTTTTGAGTTCAAAGCTATCAAAACCAAGGCCATAAAAGAGCATTTGGCAGACATTCTCAAAAAAGAAGGCCTTAGCTTTGATGAAGAAGCTTTAAGTTTGATTGCCAGACGTGCTGAAGGGGGTATGCGTGATGCCCTGTCCATTTTGGATCAGGCTCTTAGCTTAACGAATGATAATGATGTTTCGCTAGAAATAGCTGAAGAAATCACTGGCAGTATCAGCTTAAGAGCACTAGATCAGTATGTGGCTGACCTTTTGGCACATGAAACTCAGCAGGCACTCAGTGATTTAGATACTATTTTTAACAATGGCAAGAGTATGAGCCGTTTTGCGACAGATCTTTTAAATTATCTGCGTGACCTTCTGGTTGTCCAAGCGGGCGGAGAAAACACGCATCATGGAGAAGCATTTGACAAAAATCTTACCTTATCACAAGAGACTATTTTTCAAATGATTGACGTTGTGACCAAAAGTCTACCGGAAATCAAAAACGGAACACATCCCAAGATTTATGCGGAAATGATGACCATTCGCCTATCTGAAAATGACCAGAAAGTTCATTCAGTTCAAGATTTACCGGATAATGTTGCTCAAGAAATTGAAGCGCTCAAATCGGAGATTAAAGAACTCAAAAAAAGCTTGCAATCTCTGGAAAAAGGCAAGCCTTTCAAAGTGACCAAGGTTCAAAAGACTTCCTTCCGCTATAAAGTGGATAAGGACAAGGTCATGACCATTATGCGAGAAACCGTGGCAGATAGTCAAAAATCGCGTGAGTATTTAGAAGCCCTCAAAGGTTCTTGGAATGAAATTTTAGACAGCATTTCACCTCAAGACCGAGCCCTTTTAATGGGGTCTGAGCCTGTTCTTGCTAACAGCGAAAATGCTATCTTGGCCTTTGATGCTGCCTTTAATGCCGAACAAGCTATGAAACGCTCAGATCTCAATGCTATGTTTGGCAATATCATGAGTCAGGCTTCTGGCTTTTCCCCAAAAATTATGGCTGTGCCAAGAGCTGAGTTTGATGCCATCCGTAGCGAATTTGCTCATAGCCTAAAGGCAGACAAAGATGATTCTCAAGAAGAAACAACAGAAGCAACAAAAGAGTTTATCCCCGAAGGCTTTGACTTCTTAGCGGATAAAATTGTCCTTGAAGAAGAGCCATAA","5.00","-20.22","62187","MYQALYRKYRSQTFDEMVGQEVVAKTLKQAVASKKISHAYLFSGPRGTGKTSAAKIFAKAMNCPHQADGEPCNNCDICHDITNGSLEDVIEIDAASNNGVDEIREIRDKSTYAPSRATYKVYIIDEVHMLSTGAFNALLKTLEEPTENVVFILATTELHKIPATILSRVQRFEFKAIKTKAIKEHLADILKKEGLSFDEEALSLIARRAEGGMRDALSILDQALSLTNDNDVSLEIAEEITGSISLRALDQYVADLLAHETQQALSDLDTIFNNGKSMSRFATDLLNYLRDLLVVQAGGENTHHGEAFDKNLTLSQETIFQMIDVVTKSLPEIKNGTHPKIYAEMMTIRLSENDQKVHSVQDLPDNVAQEIEALKSEIKELKKSLQSLEKGKPFKVTKVQKTSFRYKVDKDKVMTIMRETVADSQKSREYLEALKGSWNEILDSISPQDRALLMGSEPVLANSENAILAFDAAFNAEQAMKRSDLNAMFGNIMSQASGFSPKIMAVPRAEFDAIRSEFAHSLKADKDDSQEETTEATKEFIPEGFDFLADKIVLEEEP","1510442","For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0074 (dnaK);SMu075 (dnaJ); SMu0745 (dnaG); SMu1091 (dnaE); SMu1745 (dnaI);SMu1746 (dnaB) and SMu1940 (dnaC).For DNA polymerase III, beta subunit see SMu0002. For DNA polymerase III alpha subunit see SMu0110. For DNA polymerase III, delta prime subunit see SMu1514. ","DNA polymerase III subunits gamma and tau","Cytoplasm","Significant hits in gapped BLAST to DNA polymerase IIIgamma and tau subunits:residues 1-552 are 69% similar to gi15675296 in S.pyogenes. Residues 1-557 are 60% similar to gi15902813 in S.pneumoniae. Residues 2-553 are 48% similar to gi15674176 in L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0828 (0.0).","

InterPro
IPR001270
Family

Chaperonin clpA/B
PR00300	$\"[40-58]T$ $\"[123-141]T$	CLPPROTEASEA

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[36-176]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[39-229]T$	AAA

InterPro
IPR008921
Domain

DNA polymerase III clamp loader subunit, C-terminal
SSF48019	$\"[243-351]T$	Pol_clamp_load_C

InterPro
IPR012763
Domain

DNA polymerase III, subunits gamma and tau
TIGR02397	$\"[2-351]T$	dnaX_nterm

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.60	$\"[178-241]T$	G3DSA:1.10.8.60
G3DSA:3.40.50.300	$\"[2-176]T$	G3DSA:3.40.50.300
PTHR11669	$\"[96-544]T$	PTHR11669
SSF52540	$\"[14-222]T$	SSF52540

","BeTs to 17 clades of COG0470COG name: ATPase involved in DNA replicationFunctional Class: LThe phylogenetic pattern of COG0470 is AMTKYQVCEBRHUJGPOLINXNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 425-532 are 73% similar to a (DNA POLYMERASE III PROTEOME) protein domain (PD357200) which is seen in Q9EVR1_STRPY.Residues 229-350 are 64% similar to a (DNA POLYMERASE III SUBUNIT) protein domain (PD133923) which is seen in Q9EVR1_STRPY.Residues 44-255 are 22% similar to a (C PROTEOME FACTOR SUBUNIT) protein domain (PD290722) which is seen in Q9HN59_HALN1.Residues 240-355 are 44% similar to a (III PROTEOME BETA COMPLETE) protein domain (PD399600) which is seen in Q9CDM5_LACLA.Residues 38-140 are 36% similar to a (DNA POLYMERASE III SUBUNIT) protein domain (PD345569) which is seen in O69546_MYCLE.Residues 16-155 are 56% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9JTS1_NEIMA.Residues 8-61 are 88% similar to a (SUBUNIT REPLICATION DNA FACTOR ACTIVATOR ATP-BINDING) protein domain (PD022232) which is seen in Q9EVR1_STRPY.Residues 23-63 are 56% similar to a (DNA POLYMERASE III GAMMA) protein domain (PD022234) which is seen in O51417_BORBU.Residues 189-223 are 74% similar to a (SUBUNIT DNA REPLICATION POLYMERASE III FACTOR COMPLETE) protein domain (PD001148) which is seen in Q9EVR1_STRPY.Residues 70-140 are 95% similar to a (DNA POLYMERASE III SUBUNIT) protein domain (PD035127) which is seen in Q9EVR1_STRPY.Residues 142-177 are 86% similar to a (DNA POLYMERASE III SUBUNIT) protein domain (PD191176) which is seen in Q9CDM5_LACLA.Residues 120-266 are 28% similar to a (III PROTEOME GAMMA COMPLETE) protein domain (PD178189) which is seen in O83533_TREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 1 10:07:45 2006","Tue Aug 1 10:07:45 2006","Tue Aug 1 10:07:45 2006","Thu Mar 14 13:03:11 2002","","Thu Mar 14 13:03:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1437 is paralogously related (blast p-value < 1e-3) to SMu1514,a predicted DNA polymerase III, delta prime subunit; SMu1866, a predicted chromosome segregation helicase (ATPase related to the helicase subunit of the Holliday junction resolvase) and SMu1334, a predicted ORF2.","Thu Mar 14 13:10:45 2002","","No significant hits to the NCBI PDB database.","SMU.1581c","","Residues 39 to 229 (E-value = 4.3e-11) place SMu1437 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)","Thu Mar 14 13:03:11 2002","","","","Flower,A.M. and McHenry,C.S.The adjacent dnaZ and dnaX genes of Escherichia coli are containedwithin one continuous open reading frameNucleic Acids Res. 14 (20), 8091-8101 (1986)PubMed: 3534795Yin,K.C., Blinkowa,A. and Walker,J.R.Nucleotide sequence of the Escherichia coli replication gene dnaZXNucleic Acids Res. 14 (16), 6541-6549 (1986)PubMed: 3018672Blinkowa,A.L. and Walker,J.R.Programmed ribosomal frameshifting generates the Escherichia coliDNA polymerase III gamma subunit from within the tau subunitreading frameNucleic Acids Res. 18 (7), 1725-1729 (1990)PubMed: 2186364","","Thu Mar 14 13:09:25 2002","1","","","SMU.1581c","91" "SMu1438","1512600","1512103","498","ATGAAAAATCAAGAAAAAATTTCGGCTTATCAAATTTTACTGGCTCAGGCACAATCGATGTTTGCCAATGAAACAAATGCTTTGGCCAATTTAGCCAATGCTACAGCCATGCTGAATAAGACTCTTCCTAATGCCATCTTTACAGGATTTTATCTTTTTGACGGTGAAGAACTTGTCTTAGGTCCTTTCCAAGGTGGTGTCTCTTGTGTGCGTATTGCTCTTGGAAAGGGTGTCTGTGGTCAGGCTGCTGCCAAAAAACAAACACTTATCGTAGGAGATGTCACCAAGCATGATAATTATATTTCCTGCGATTCAGCCGCTATGAGTGAAATTGTTATTCCTATGGTAAAAGACGGTCAGCTTATTGGTGTGCTGGATTTAGATTCACACTTAGTCGGTGATTATGATGTTATCGATCAAGGCTATTTAGAACAATTTGTGACAATTCTTCTGGAAAAAACAAATTGGCATTTTGACATGTTTGGAGTGAAAGACTGA","4.50","-7.43","17937","MKNQEKISAYQILLAQAQSMFANETNALANLANATAMLNKTLPNAIFTGFYLFDGEELVLGPFQGGVSCVRIALGKGVCGQAAAKKQTLIVGDVTKHDNYISCDSAAMSEIVIPMVKDGQLIGVLDLDSHLVGDYDVIDQGYLEQFVTILLEKTNWHFDMFGVKD","1512118","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypotheticalproteins: residues 1-165 are 57% similar to S.pyogenes (gi|15675297|) and residues 1-164 are 57% similar to S.pneumoniae (gi|15902812|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0827 (4e-56).","

InterPro
IPR003018
Domain

GAF
SM00065	$\"[26-155]T$	GAF

noIPR
unintegrated

unintegrated
G3DSA:3.30.450.40	$\"[1-157]T$	G3DSA:3.30.450.40
PTHR21021	$\"[18-150]T$	PTHR21021
PTHR21021:SF15	$\"[18-150]T$	PTHR21021:SF15
SSF55781	$\"[1-150]T$	SSF55781

","BeTs to 4 clades of COG1956COG name: GAF domain-containing proteinsFunctional Class: TThe phylogenetic pattern of COG1956 is ----y-v-eb-----------Number of proteins in this genome belonging to this COG is 1","***** IPB000614 (Uncharacterized protein family UPF0067) with a combined E-value of 5.8e-09. IPB000614 93-115","Residues 10-80 are 40% similar to a (COMPLETE PROTEOME BH3208 NMB1886) protein domain (PD019899) which is seen in Q9CDM3_LACLA.Residues 82-150 are 66% similar to a (COMPLETE PROTEOME BH3208 NMB1886) protein domain (PD015109) which is seen in Q9CDM3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:24:07 2002","Thu Mar 14 13:13:02 2002","Thu Mar 14 13:13:02 2002","Thu Mar 14 13:13:02 2002","Thu Mar 14 13:13:02 2002","Thu Mar 14 13:13:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1438 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:24:07 2002","Thu Mar 14 13:13:02 2002","pdb|1F5M|A Chain A, Structure Of The Gaf Domain >gi|11513782|pd... 96 3e-021pdb|1F5M|A Chain A, Structure Of The Gaf Domain >gi|11513782|pd... 183 1e-047","SMU.1582c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 13:13:02 2002","24379965","","","","","","1","","","SMU.1582c","787" "SMu1439","1514686","1512917","1770","ATGTATTATTCAAATGGTAACTATGAAGCCTTTGCTCATCCACAAAAACCTGAAAATGTTGATGGGAAATCAGCTTATATTGTTGGAAGCGGCTTAGCGGCTCTTTCTACAGCAGTTTTTCTTATTCGTGACGGACAAATGGCTGGAGAACGCATTCATATTCTTGAAGAATTATCTCTTCCTGGTGGCAGTATGGATGGTATTCGTAATGAACGTTTAGGTTACATCATTCGCGGTGGTCGGGAAATGGAGCCTCACTTTGAAGTCTTATGGGATTTATTTCGCTCTATCCCTTCTCTGGAAAATCCCAAACACTCTATTTTAGATGAATTCTACTGGCTTAATAAAAAGGATCCAAGTTTTGCTAAAACACGTGCCATCTATGAGCGTGGAAAGGCAATACCAGATGACGGTCAGTTGACCTTATCTCAAAAAGCAGTTAAGGAAATTTTTGATCTTGTTCTAACACCGGAAAGTCATCTGCAGGATGTTCAGATTGATCAAGTCTTTAGTGAAGATTTCTTCAACTCTAACTTCTGGCTTTATTGGAGTACCATGTTTGCTTTTGAACCATGGGCCAGTGCTATGGAAATGCGCCGTTACCTCATGCGATTCATTCAGCATGTTGGGACTTTGAAAAATCTCTCATCCTTAAAATTCACACAATACAATCAATATGAATCATTGATCTTACCACTAGTAGCTTTTCTCAAAGACCATAATGTCAATTTTAGCTATCAGACTGTTGTCACTAATATTTTAGTCAATCGTTCTGGCAGTGATAAGCTTGCTACTAAAATTGAAATGACTGTTAATGGTCAAGAAAAAAGTATTGCTTTAAGTAGAGATGATCTTGTTTTTGTCACCAATGGCTCCATTACAGAAAGTAGTACTTACGGTAACAATAATCATCCAGCTCCATTAACGCACGATCTTGGTGCCAGTTGGCAGCTGTGGAAGAATTTAGCTGCACAAGATAGTGATTTTGGATGTCCCGAAAAATTCTGTGAAAATATCCCTGATGCTAATTGGACCATGTCTGCTACAATAACTTTTACAGATCAACGCATTGCTAAATACATTGAACAGATTAACCAAAAGGATCCTTATAGTGGCTCTATTGTAACCAGCGGACCTACCAGCATTAAAGATTCTAGTTGGTTGCTTGGCTATTCTATCAGTCGACAACCACATTTTAAAGAACAAAAGAAAAATGAGCTTGTTATCTGGCTCTATGCTCTCTATACTGATCGCAAAGGAGATTATGTCGCTAAACGGCCTGATGAATGTACAGGGATTGAAATGTGTGAAGAATGGCTTTATCATATAGGAGTTCCTGAAAATACTATTCATGAACTAGCCTGTTCGGCCTCGACGATCCCTTGCCATATGCCTTATATAACAACGTATTTCATGCCGCGAACAACTAACGATCGCCCACTTGTTGTGCCAAAACATAGTAAGAATTTAGCTTTTATAGGAAACTATGCTGAAACACCGCGAGATACGGTTTTTACAACAGAATATTCTGTCAGAACTGCTATGGAAGCTGTTTACACTTTACTTGAAGTTGATCGTGGTGTCCCTGAAGTGTTTGCTTCAACTTTTGATATTCGCATGCTACTTAATGCGCTTTACTATCTCAATGGTCAAAAATCTTTAATAGAAATTGATTTTCCTTGGGTGGAAAAAGCAGCCCTTAAAGAAGCTCTCAAAAAGGTTAAAGGAACATACATAGAAGAATTATTGAAAGATTATCATCTGATTTAG","5.60","-12.62","67339","MYYSNGNYEAFAHPQKPENVDGKSAYIVGSGLAALSTAVFLIRDGQMAGERIHILEELSLPGGSMDGIRNERLGYIIRGGREMEPHFEVLWDLFRSIPSLENPKHSILDEFYWLNKKDPSFAKTRAIYERGKAIPDDGQLTLSQKAVKEIFDLVLTPESHLQDVQIDQVFSEDFFNSNFWLYWSTMFAFEPWASAMEMRRYLMRFIQHVGTLKNLSSLKFTQYNQYESLILPLVAFLKDHNVNFSYQTVVTNILVNRSGSDKLATKIEMTVNGQEKSIALSRDDLVFVTNGSITESSTYGNNNHPAPLTHDLGASWQLWKNLAAQDSDFGCPEKFCENIPDANWTMSATITFTDQRIAKYIEQINQKDPYSGSIVTSGPTSIKDSSWLLGYSISRQPHFKEQKKNELVIWLYALYTDRKGDYVAKRPDECTGIEMCEEWLYHIGVPENTIHELACSASTIPCHMPYITTYFMPRTTNDRPLVVPKHSKNLAFIGNYAETPRDTVFTTEYSVRTAMEAVYTLLEVDRGVPEVFASTFDIRMLLNALYYLNGQKSLIEIDFPWVEKAALKEALKKVKGTYIEELLKDYHLI","1512932","","67 kDa myosin-crossreactive streptococcal antigen","Membrane, Cytoplasm","Matches in gapped BLAST to primarily 67 kDa myosin-crossreactivestreptococcal antigens. Residues 1-589 are 58% similar to gi|15923096| from S.aureus and 55% similar to gi|15674587| from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1508 (0.0).","

InterPro
IPR010354
Family

Streptococcal 67 kDa myosin-cross-reactive antigen like
PF06100	$\"[21-519]T$	Strep_67kDa_ant

noIPR
unintegrated

unintegrated
SSF51905	$\"[1-527]T$	SSF51905

","BeTs to 3 clades of COG0493COG name: NADPH-dependent glutamate synthase beta chain and related oxidoreductasesFunctional Class: E,RThe phylogenetic pattern of COG0493 is ---KYqVcEbR------l--xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 285-589 are 53% similar to a (ANTIGEN MYOSIN-CROSSREACTIVE PROTEOME) protein domain (PD129968) which is seen in Q54525_STRPY.Residues 1-284 are 60% similar to a (COMPLETE ANTIGEN SEQUENCE) protein domain (PD040258) which is seen in Q53721_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 13:24:41 2002","Wed Apr 24 16:26:57 2002","Thu Oct 17 14:50:28 2002","Thu Mar 14 13:16:43 2002","","Thu Mar 14 13:16:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1439 is paralogously related (blast p-value < 1e-3) to SMu0467, a predicted 67 kDa myosin-crossreactive antigen.","Thu Mar 14 13:24:41 2002","","No significant hits to the NCBI PDB database.","SMU.1584c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 13:16:43 2002","24379966","","","Dale JB, Beachey EH.Epitopes of streptococcal M proteins shared with cardiac myosin.J Exp Med. 1985 Aug 1;162(2):583-91.PMID: 2410530","","Mon Mar 18 10:11:53 2002","1","","","SMU.1584c","" "SMu1440","1515329","1514805","525","ATGAACAATTTAACAGAACAAGCTTTTGCTAGAGCTTTGAAAGAAATCATGGCAAAAAAATCTTTTGATAAGGTGACCGTAACCGAGCTCGTTCGATTTTTAAATGTTAACCGACAAACTTTCTATTATCACTTTAAAGATTTATATGATTTATTAGAATGGATCTATATCACAGATGGCGAAAAAATGATTGGTGATAAACGAACGACTGCTTCTTGGCAGGAGGGTCTATTAGCAATATTTCAGTATATTCAAGATAACGAGGCCTTTGTCCGTAACACTTATCATTCCATTAATCGCAATTATTTGGAACATTTTTTATATGATAGAGCCTACAGCCTTATTAGACCAGTTATTGAAGAAAATGAAATTCAAACACAGATTAGTGAAGCCGATATTGATTTGCGCGCACATTTTTATAAATACGGTCTGGTTGGTTTTATCTTAGATTGGATCGATTCAGGACTGCGTGAAAAGCCAGAAGATTTAACACAGCGTATTTATCATTTACTGGAAAGTTTATAG","5.20","-5.79","20834","MNNLTEQAFARALKEIMAKKSFDKVTVTELVRFLNVNRQTFYYHFKDLYDLLEWIYITDGEKMIGDKRTTASWQEGLLAIFQYIQDNEAFVRNTYHSINRNYLEHFLYDRAYSLIRPVIEENEIQTQISEADIDLRAHFYKYGLVGFILDWIDSGLREKPEDLTQRIYHLLESL","1514820","","transcriptional regulator","Cytoplasm","Limited matches in gapped BLAST to transcriptional regulators.Residues 4-170 are 32% similar to gi|16802523| from L.monocytogenes and 32% similar to gi|16799557| from L.innocua. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1648 (8e-12).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PS50977	$\"[3-63]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[5-67]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[2-66]T$	Homeodomain-rel

","BeTs to 7 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 3e-06. IPB001647 21-51","Residues 5-134 are 27% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD106875) which is seen in Q9CIV9_LACLA.Residues 4-171 are 28% similar to a (PROTEOME COMPLETE BH3394) protein domain (PD399751) which is seen in Q9K7G7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:49:25 2002","Thu Mar 14 13:28:57 2002","Thu Oct 17 14:49:25 2002","Thu Mar 14 13:28:57 2002","Thu Mar 14 13:28:57 2002","Thu Mar 14 13:28:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1440 is paralogously related (blast p-value < 1e-3) to SMu0466, SMu1936, SMu1069, SMu0398, SMu1171, and SMu1139 all predicted transcriptional regulators.","Thu Mar 14 13:28:57 2002","","No significant hits to the NCBI PDB database.","SMU.1585c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 13:28:57 2002","24379967","","","","","","1","","","SMU.1585c","" "SMu1441","1517582","1515633","1950","ATGATTAAGATTACTTTCCCAGATGGCGCTGTGCGCGAGTTTGAAATTGGTACAACAACGTCTGAAATTGCTGAGTCTATCAGCAAGTCTCTTGCAAAGAAAGCTTTGGCTGGTAAATTTAACGGTCAGCTTATTGATACCACACGCGCTATCACGCAAGATGGCAGCATTGAAATTGTGACACCTGACCACGAAGATGCTTTAGACATCTTGCGCCACTCGGCAGCTCACTTGTTTGCGCAAGCAGCTCGCCGCCTTTTCCCAGATATTCACTTGGGTGTCGGTCCAGCTATTCAAGATGGTTTCTACTACGATACGGACAATGAAGCAGGGCAAATTTCCAACGAAGATCTTCCTCGTATTGAAGAGGAAATGAAGAAAATTGTCAAAGAAAACTTCCCATCAGTCCGTGAAGAAGTCACTAAGGATGAGGCACGCGAAATTTTCAAAAATGACCCTTACAAACTCGAATTGATCGAAGAACACTCAGAAGATGCAGGTGGTTTAACAATTTACCGTCAAGGCGAATACGTTGACCTCTGCCGCGGACCGCACGTGCCGTCAACCGGCCGTATCCAAGTCTTTCATCTACTTAACGTGGCTGGTGCTTACTGGCGCGGTGACAGTAACAATGCTATGATGCAGCGTATCTATGGTACCGCTTGGTTTGATAAGAAAGATCTCAAATCTTACCTCAAACGCCTTGAAGAAGCTAAAGAACGCGATCATCGTAAATTAGGTAAAGAATTAGATCTTTTCATGATTTCTCAAGAAGTTGGTCAAGGTTTGCCGTTCTGGCTACCAGATGGTGCAACAATCCGTCGCATCATTGAGCGTTACATCACTGATAAGGAAGTCGCTTCGGGCTATCAACATGTCTACACACCGCCAATTGCCTCTGTTGACCTTTACAAGACCTCAGGTCACTGGGATCATTACCGTGAAGATATGTTTCCAACTATGGACATGGGAGATGGTGAATCCTTTGTTTTGCGTCCGATGAACTGTCCTCATCACATTGAAGTTTATAAGAATCATGTGCATTCTTATCGTGAATTGCCAATTCGTATTGCGGAACTTGGGATGATGCACCGTTATGAAAAATCAGGTGCTTTATCGGGACTTCAGCGTGTGCGTGAAATGACACTAAATGATGGTCACACTTTTGTTGCTCTTGATCAAGTGGAAGATGAGTTTAAGCGTACCCTCCAATTAATTATTGATGTCTATGAAGACTTCAATTTAACAGATTATAGTTTCCGTTTATCTTATCGTGACCCTAATGATACCCATAAATATTTCGATGACGATGAAATGTGGGAAAAATCGCAGACCATGCTGAAAGCTGCTATGGATGATATGGGCTTAGATTATTACGAAGCAGAAGGCGAAGCAGCTTTTTACGGACCAAAATTGGATATCCAAGTCAAGACTGCTCTTGGCAATGATGAAACTTTGTCAACGATTCAATTGGACTTCTTGCTGCCAGAGCGCTTTGAATTAACCTATATTGGTGCTGATGGCGAAGAACATCGACCAGTCATGATTCACCGCGGTATCGTTTCAACCATGGAACGCTTCACAGCTTACCTTATTGAAACCTATAAAGGAGCTTTTCCAACTTGGTTAGCTCCGCATCAAGTAACTGTCATTCCAATCTCAAACGAAGCTCACATTGACTATGCTTGGGAAGTTGCTAAAGAACTGCGTGACCATGGTATTCGCGCTGATGTAGATGACCGTAATGAAAAAATGCAGTATAAGATTCGTCAAAGTCAGACTAAGAAAGTACCTTACCAACTCATTGTTGGTGATAAGGAAGTGGAAAACGGTACCGTTAATGTCCGACGTTATGGCAGCAAGCAAACGCATACGGAAAGTATCGCAGAGTTTAGAGAGAACATTTTAGCTGATATCAAGCGTAAATCACGCCCAGACAACGCTAAATAA","5.20","-25.22","74751","MIKITFPDGAVREFEIGTTTSEIAESISKSLAKKALAGKFNGQLIDTTRAITQDGSIEIVTPDHEDALDILRHSAAHLFAQAARRLFPDIHLGVGPAIQDGFYYDTDNEAGQISNEDLPRIEEEMKKIVKENFPSVREEVTKDEAREIFKNDPYKLELIEEHSEDAGGLTIYRQGEYVDLCRGPHVPSTGRIQVFHLLNVAGAYWRGDSNNAMMQRIYGTAWFDKKDLKSYLKRLEEAKERDHRKLGKELDLFMISQEVGQGLPFWLPDGATIRRIIERYITDKEVASGYQHVYTPPIASVDLYKTSGHWDHYREDMFPTMDMGDGESFVLRPMNCPHHIEVYKNHVHSYRELPIRIAELGMMHRYEKSGALSGLQRVREMTLNDGHTFVALDQVEDEFKRTLQLIIDVYEDFNLTDYSFRLSYRDPNDTHKYFDDDEMWEKSQTMLKAAMDDMGLDYYEAEGEAAFYGPKLDIQVKTALGNDETLSTIQLDFLLPERFELTYIGADGEEHRPVMIHRGIVSTMERFTAYLIETYKGAFPTWLAPHQVTVIPISNEAHIDYAWEVAKELRDHGIRADVDDRNEKMQYKIRQSQTKKVPYQLIVGDKEVENGTVNVRRYGSKQTHTESIAEFRENILADIKRKSRPDNAK","1515648","For other 'thr' genes see SMu0063 (thrC); SMu0877 (thrB) and SMu1594 (thrA).","threonyl-tRNA synthetase","Cytoplasm","Several matches in gapped BLAST to threonyl-tRNA synthetase: residues 1-646 are 84% similar to the enzyme in S.pyogenes (gi|15674621|).Residues 1-644 are 83% similar to the protein from S.pneumoniae (gi|15901467|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0711 (0.0).","

InterPro
IPR002314
Domain

tRNA synthetase, class II (G, H, P and S)
PF00587	$\"[273-444]T$	tRNA-synt_2b

InterPro
IPR002320
Family

Threonyl-tRNA synthetase, class IIa
PR01047	$\"[331-359]T$ $\"[364-387]T$ $\"[470-498]T$ $\"[513-526]T$ $\"[540-552]T$	TRNASYNTHTHR
TIGR00418	$\"[72-639]T$	thrS

InterPro
IPR004095
Domain

TGS
PF02824	$\"[2-61]T$	TGS

InterPro
IPR004154
Domain

Anticodon-binding
G3DSA:3.40.50.800	$\"[537-649]T$	Anticodon_bd
PF03129	$\"[547-638]T$	HGTP_anticodon
SSF52954	$\"[533-641]T$	Anticodon_bd

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[242-540]T$	AA_TRNA_LIGASE_II

InterPro
IPR012675
Domain

Beta-grasp fold, ferredoxin-type
G3DSA:3.10.20.30	$\"[1-64]T$	Ferredoxin_fold

InterPro
IPR012676
Domain

TGS-like
SSF81271	$\"[2-62]T$	TGS-like

InterPro
IPR012947
Domain

Threonyl/alanyl tRNA synthetase, SAD
PF07973	$\"[169-218]T$	tRNA_SAD

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[241-536]T$	G3DSA:3.30.930.10
G3DSA:3.30.980.10	$\"[65-232]T$	G3DSA:3.30.980.10
PTHR11451	$\"[175-642]T$	PTHR11451
PTHR11451:SF5	$\"[175-642]T$	PTHR11451:SF5
SSF55186	$\"[63-240]T$	SSF55186
SSF55681	$\"[241-538]T$	SSF55681

","BeTs to 17 clades of COG0441COG name: Threonyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0441 is amtkYqVceBrhujgpoLinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 512-615 are 66% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000606) which is seen in Q9CED2_LACLA.Residues 258-318 are 78% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD004144) which is seen in Q9K866_BACHD.Residues 70-200 are 84% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ALANYL-TRNA) protein domain (PD001534) which is seen in Q9CED2_LACLA.Residues 458-510 are 84% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD002782) which is seen in Q9CED2_LACLA.Residues 138-204 are 46% similar to a (SYNTHETASE LIGASE ATP-BINDING) protein domain (PD190155) which is seen in SYT_UREPA.Residues 1-68 are 64% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD006784) which is seen in Q9CED2_LACLA.Residues 71-126 are 51% similar to a (SYNTHETASE LIGASE BIOSYNTHESIS) protein domain (PD379309) which is seen in Q9L278_STRCO.Residues 415-457 are 81% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD346423) which is seen in Q9CED2_LACLA.Residues 205-258 are 68% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD351577) which is seen in Q9JVA3_NEIMA.Residues 325-410 are 66% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD276857) which is seen in Q9K866_BACHD.Residues 327-413 are 75% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000380) which is seen in SYT1_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 14:49:04 2002","Thu Mar 14 13:33:30 2002","Thu Oct 17 14:49:04 2002","Thu Mar 14 13:31:45 2002","","Thu Mar 14 13:31:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1441 is paralogously related (blast p-value < 1e-3) to SMu1623, a predicted prolyl-tRNA synthetase; SMu1714,a predicted seryl tRNA synthetase and SMu0592, a predicted alanyl-tRNA synthetase (alanine--tRNA ligase).","Thu Mar 14 13:31:45 2002","Thu Mar 14 13:31:45 2002","pdb|1QF6|A Chain A, Structure Of E. Coli Threonyl-Trna Syntheta... 511 7e-146pdb|1EVK|A Chain A, Crystal Structure Of A Truncated Form Of Th... 311 2e-085","SMU.1586c","","Residues 1 to 61 (E-value = 2.6e-10) place SMu1441 in the TGS family which is described as TGS domain (PF02824)Residues 262 to 417 (E-value = 7.6e-49) place SMu1441 in the tRNA-synt_2b family which is described as tRNA synthetase class II core domain (G, H, P, S and T) (PF00587)Residues 547 to 638 (E-value = 7.9e-33) place SMu1441 in the HGTP_anticodon family which is described as Anticodon binding domain (PF03129)","Thu Mar 14 13:31:45 2002","","","","Putzer,H., Brakhage,A.A. and Grunberg-Manago,M.Independent genes for two threonyl-tRNA synthetases in BacillussubtilisJ. Bacteriol. 172 (8), 4593-4602 (1990)PubMed: 2115870Putzer,H., Gendron,N. and Grunberg-Manago,M.Co-ordinate expression of the two threonyl-tRNA synthetase genes in Bacillus subtilis: control by transcriptional antiterminationinvolving a conserved regulatory sequenceEMBO J. 11 (8), 3117-3127 (1992)PubMed: 1379177","","Thu Mar 14 13:34:56 2002","1","","","SMU.1586c","73" "SMu1442","1518217","1517579","639","ATGGTGATTTATATGATTGGCGGATCGCCTTGTAGTGGGAAGTCAACAATTGCTTCACTTCTTGCTAGACAGTATCAGCTGCTTCATATCAAGCTGGATGATTTGGTAGACGAGATGATGAGTCAAGCAAGTGCAGACTCACAGCCGATTTGCCTTCTTAGACAGGACAGAAATCCGGAACAAATCTGGATGAGAAATCCAAAAGAGATGGCAGATGAAGAATGGCGCTTTTATGAAGAGATTTTTCCTTATGTAAAATCTTACTTGATAAAAAAAGATAGACCACTCTTGGTTGAGGGGGCAGGACTTTTGCCTCACTTGGTAAAGGAGCTTGAATGGCCAGCGTCTTCCTATCTATGCTTGACTCCGACAGCTGATTTTCAGAAAAAGCATTATAGGCAGAGAGAATGGGTTTCTTATGTCTTAGAGGGAACAACCAATCCTGAGCAAGCTTTTGAAAACTGGATGCAGCGAGACATTCTTTTTGCCCAAATGGTTCGTAAGGAAGCGATGAGATTAGGCTATTCTAGCCTCATGACAGATGGTAGTCAATCAGAAAAGCAGACTGCGGAAGAGATTGCTCGGCTCTTAAAATTGTACAATATAAATGAAATAGATATTAAAGGAGAAAACACATGA","5.10","-5.41","24692","MVIYMIGGSPCSGKSTIASLLARQYQLLHIKLDDLVDEMMSQASADSQPICLLRQDRNPEQIWMRNPKEMADEEWRFYEEIFPYVKSYLIKKDRPLLVEGAGLLPHLVKELEWPASSYLCLTPTADFQKKHYRQREWVSYVLEGTTNPEQAFENWMQRDILFAQMVRKEAMRLGYSSLMTDGSQSEKQTAEEIARLLKLYNINEIDIKGENT","1517594","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST found.SMu1442 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-44]T$	G3DSA:3.40.50.300
SSF52540	$\"[1-198]T$	SSF52540

","BeTs to 3 clades of COG0563COG name: Adenylate kinase/yeast uridylate kinaseFunctional Class: FThe phylogenetic pattern of COG0563 is a--kYqvCebrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:22:52 2002","Thu Mar 14 13:36:37 2002","Thu Mar 14 13:36:37 2002","Thu Mar 14 13:36:37 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1442 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 13:36:37 2002","","No significant hits to the NCBI PDB database.","SMU.1587c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 13:36:37 2002","24379969","","","","","","1","","","SMU.1587c","" "SMu1443","1519816","1518482","1335","ATGCGTGTAGGTCTTTTTACAGACACCTATTTACCACAGATTTCAGGTGTTGCAACGAGTATCAAAACCCTAAAGGAAGAATTAGAAAAACAAGGACACGAGGTTTATATCTTTACAACGACTGATAAACATGTTAAACGTTATGAAGATCCAACCATTATTCGCTTACCCAGTGTTCCTTTTATTTCTTTTACCGATCGTCGAATTGTTTATCGGGGACTCTTTGAATCTTATAAAATTGCTAAAACTTATAAATTAGATATCATTCATACGCAGACAGAATTTAGTCTGGGAATATTGGGCAAAATGGTTGGCAAGGCCTTACGGATCCCTGTTATTCATACTTACCATACCCAGTATGAAGATTATGTTCGCTATATTGCTAATGGCAAGCTTATCCGTCCAAGTATGGTAAAATATATTGTTCGTGGTTTTCTCAATGATTTAGATGGGGTTATTTGTCCCAGCCGTATTGCCTTAAATTTATTAGATGGTTATTCTGTCAAGATTCCCAAGCGAATTATTCCAACAGGCATTGACTTGAGAGAATACGAGCGACCAGACATTAGTCAAGAAGATATTGCCAAACTTAGAGAAAAATGGGCTATTGCTAGTGATGAAACTGTCTTATTGAGTCTGTCAAGGGTTTCATATGAAAAAAATATTCAAGCTCTGCTTGCTAATATGCCAAAAATCTTATCTAACAATCCTAAAGTGAAGTTGCTTATTGTCGGAGATGGCCCCTATCTTGAAGAGTTGAAAGAACAGGCTCAAGATTTAGCCGTCATGGACAATGTTATTTTTACAGGAATGGTGAGTCATAATGAAACAGCTCTTTATTACAAGGCAGCTGACTTCTTTATCAGTGCGTCAACCAGTGAGACGCAAGGGCTGACCTATGCAGAAAGCTTAGCTAGTGGTAAGCCGATTATCGCTCAGTCCAATCCTTATTTAGATGATCTTATCACAGATAAGATGTTTGGAACGCTTTATCAAACAGAGTCAGATTTAGCCGATGCTGTTTTAAATGCTATCGTTTCAACTCCAGCTAAGCAGGAAAAGGTCTGGCAGAAAAAACTATATGAAATTTCAGCAGAAGCCTTTGGCAAATCAGTTTTTGCATTCTATCTGGATATGATTATTTCCAAAAAGGCTAAGAAAAAGGAAAAATGGTCCTTGGCAGTCGAAGGAAACCGAGCAGATACTTCAATTAGAATTGTCAAATCAACCATTAAACTGCCTGCAACAGCTCTTAAAAAGACCGCTAAGACTTCCGTTAAAGTGATTAAAGCGCCTGTGCGTATGGTTAATGCTATTAGAGATTTCCTTGATTAA","10.00","11.43","50106","MRVGLFTDTYLPQISGVATSIKTLKEELEKQGHEVYIFTTTDKHVKRYEDPTIIRLPSVPFISFTDRRIVYRGLFESYKIAKTYKLDIIHTQTEFSLGILGKMVGKALRIPVIHTYHTQYEDYVRYIANGKLIRPSMVKYIVRGFLNDLDGVICPSRIALNLLDGYSVKIPKRIIPTGIDLREYERPDISQEDIAKLREKWAIASDETVLLSLSRVSYEKNIQALLANMPKILSNNPKVKLLIVGDGPYLEELKEQAQDLAVMDNVIFTGMVSHNETALYYKAADFFISASTSETQGLTYAESLASGKPIIAQSNPYLDDLITDKMFGTLYQTESDLADAVLNAIVSTPAKQEKVWQKKLYEISAEAFGKSVFAFYLDMIISKKAKKKEKWSLAVEGNRADTSIRIVKSTIKLPATALKKTAKTSVKVIKAPVRMVNAIRDFLD","1518497","","glucosyl transferase, family 1","Membrane, Cytoplasm","Limited matches in gapped BLAST to glucosyl transferase: residues 1-444 are 66% similar to the enzyme in S.pyogenes (gi15674620).Residues 1-442 are 61% similar to the protein from S.pneumoniae(gi15900945).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0710 (1e-175).","

InterPro
IPR001296
Domain

Glycosyl transferase, group 1
PF00534	$\"[194-312]T$	Glycos_transf_1

noIPR
unintegrated

unintegrated
PTHR12526	$\"[2-330]T$ $\"[348-363]T$	PTHR12526
PTHR12526:SF38	$\"[2-330]T$ $\"[348-363]T$	PTHR12526:SF38
SSF53756	$\"[1-380]T$	SSF53756

","BeTs to 14 clades of COG0438COG name: Glycosyltransferases IFunctional Class: MThe phylogenetic pattern of COG0438 is AMTKYQVCEBRhUj--o---XNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 209-270 are 56% similar to a (TRANSFERASE COMPLETE PROTEOME) protein domain (PD000427) which is seen in Q9CDS5_LACLA.Residues 14-373 are 22% similar to a (PROTEOME COMPLETE) protein domain (PD323140) which is seen in Q9X0V7_THEMA.Residues 175-272 are 35% similar to a (TRANSFERASE PROTEOME COMPLETE GLYCOSYL) protein domain (PD265531) which is seen in O69579_MYCLE.Residues 187-316 are 27% similar to a (PROTEOME COMPLETE PH0426) protein domain (PD290804) which is seen in O26476_METTH.Residues 1-59 are 49% similar to a (COMPLETE PROTEOME BIOSYNTHESIS-RELATED) protein domain (PD016783) which is seen in O51410_BORBU.Residues 78-334 are 23% similar to a (GLYCOSYLTRANSFERASE) protein domain (PD272648) which is seen in Q9F754_BACFR.Residues 1-38 are 52% similar to a (PROTEOME COMPLETE SQDX) protein domain (PD336757) which is seen in Q55598_SYNY3.Residues 272-345 are 58% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD000172) which is seen in Q9CDS5_LACLA.Residues 85-247 are 28% similar to a (PROTEOME CHLOROPLAST COMPLETE) protein domain (PD122606) which is seen in P73948_SYNY3.Residues 1-118 are 31% similar to a (COMPLETE PROTEOME RELATED TRANSFERASE) protein domain (PD005309) which is seen in Q9HJA3_THEAC.Residues 1-184 are 63% similar to a (PROTEOME COMPLETE BIOSYNTHESIS) protein domain (PD190085) which is seen in Q9CDS5_LACLA.Residues 79-127 are 46% similar to a (COMPLETE PROTEOME TRANSFERASE SQDX) protein domain (PD277469) which is seen in O51410_BORBU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 13:41:42 2002","Fri Sep 8 12:27:46 2006","Fri Sep 8 12:27:46 2006","Thu Mar 14 13:40:51 2002","","Sun Dec 2 08:10:05 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1443 is paralogously related (blast p-value < 1e-3) to SMu1444, a predicted sugar transferase .","Thu Mar 14 13:41:42 2002","","No significant hits to the NCBI PDB database.","SMU.1588c","","Residues 194 to 361 (E-value = 1.4e-26) place SMu1443 in the Glycos_transf_1 family which is described as Glycosyl transferases group 1 (PF00534)","Sun Dec 2 08:10:05 2001","24379970","","Nomura Y, Eto A, Hanada N, Senpuku H. Identification of the peptide motifs that interact with HLA-DR8 (DRB1*0802) in Streptococcus mutans proteins.Oral Microbiol Immunol. 2002 Aug;17(4):209-14.PMID: 12121470","Berg,S., Edman,M., Li,L., Wikstrom,M. and Wieslander,A.Sequence properties of the 1,2-diacylglycerol 3-glucosyltransferase from Acholeplasma laidlawii membranes. Recognition of a large group of lipid glycosyltransferases in eubacteria and archaeaJ. Biol. Chem. 276 (25), 22056-22063 (2001)PubMed: 11294844Koo H, Sheng J, Nguyen PT, Marquis RE.Co-operative inhibition by fluoride and zinc of glucosyl transferase production and polysaccharide synthesis by mutans streptococci in suspension cultures and biofilms.FEMS Microbiol Lett. 2006 Jan;254(1):134-40.PMID: 16451191","Fri Oct 25 13:49:44 2002","Tue Apr 24 12:54:04 2007","1","","","SMU.1588c","307" "SMu1444","1520816","1519818","999","ATGAAAGTTTTATTGTATTTGGAGGCGGAGCATTACTTGAGAAAATCAGGTATTGGTCGTGCCATCAAACATCAAGAACGCGCCTTGACTTTGGCAGGAATTGATTACACAACCAATCCTGAAGATGATTACGATTTGGTTCATATTAATACTTATGGTCTGAAAAGCTGGCGCTTAATGAAACGTGCTAAGAAGGCTGGGAAAAAAGTTATCATGCACGGACATTCAACCGAAGAAGATTTTAGGAATTCTTTTGTTGGTTCTAATTGGATTGCTCCATTTTTTAAAAAATACCTTTGCCGCTTTTATAAAGAAGCTGATGCTATTATTACACCAACACCTTATTCAAAACGGCTCATTGCAGGATATGGGATTACCAACCCTATCTATGTTGTCTCAAATGGTATTGATTTAGCGCGCTATGTTCCTGATCAGGCTAAGGAAGCCGCTTTTCGTCAGCATTTTCAGTTAACTGGTGACGAGCAGGTTGTTGTATGTGCGGGTCTTTACTTTAAACGCAAGGGAATTGAAGATTTTATTAAAGTAGCCCAAAGAATGCCTCATGTGCGTTTTATTTGGTTTGGCGAAACGAATAAATGGGTTATTCCCCATGACGTCAGAGCTATTGTTGCTAAGAAGCATCCTGATAATGTTACTTTTGCAGGTTATATAAAAGGCGATGTTTTCGAAGGAGCAATGAGCGGTGCTGATGCTTTCTTCTTTCCAAGTCTTGAAGAAACTGAAGGTATTGTTGTTTTAGAAGCCTTAGCTAGTCATCAGCATGTTATTTTAAGAGACATTCCTGTTTATAAAGGCTGGATAACTGATGAAGCAGTTGAGTTTGCAACAACGGTTGAAGGATTTGAAGAAGCTATTCAAAAGGTTCTTGATGGTCACAGTCAAAAGACAGAGGCAGGTTATTTAGTCGCCCAAAGTCGTAATATTGATAAGGTGGCTCATGACTTGGCTCAAGTCTACCAAAAAGTTATGGAGGGGTAG","7.80","3.05","37696","MKVLLYLEAEHYLRKSGIGRAIKHQERALTLAGIDYTTNPEDDYDLVHINTYGLKSWRLMKRAKKAGKKVIMHGHSTEEDFRNSFVGSNWIAPFFKKYLCRFYKEADAIITPTPYSKRLIAGYGITNPIYVVSNGIDLARYVPDQAKEAAFRQHFQLTGDEQVVVCAGLYFKRKGIEDFIKVAQRMPHVRFIWFGETNKWVIPHDVRAIVAKKHPDNVTFAGYIKGDVFEGAMSGADAFFFPSLEETEGIVVLEALASHQHVILRDIPVYKGWITDEAVEFATTVEGFEEAIQKVLDGHSQKTEAGYLVAQSRNIDKVAHDLAQVYQKVMEG","1519833","","glycosyl transferase, family 1","Cytoplasm","Several matches in gapped BLAST to sugar transferase: residues 1-331 are 69% similar to the enzyme in S.pyogenes (gi15674619) and are 65% similar to the protein from S.pneumoniae (gi15900945).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0709 (1e-145).","

InterPro
IPR001296
Domain

Glycosyl transferase, group 1
PF00534	$\"[148-313]T$	Glycos_transf_1

noIPR
unintegrated

unintegrated
PTHR12526	$\"[41-331]T$	PTHR12526
SSF53756	$\"[1-331]T$	SSF53756

","BeTs to 11 clades of COG0438COG name: Glycosyltransferases IFunctional Class: MThe phylogenetic pattern of COG0438 is AMTKYQVCEBRhUj--o---XNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 223-331 are 65% similar to a (PROTEOME GLYCOSYLTRANSFERASE COMPLETE) protein domain (PD395208) which is seen in Q9CDS6_LACLA.Residues 160-222 are 66% similar to a (PROTEOME GLYCOSYLTRANSFERASE COMPLETE) protein domain (PD064089) which is seen in Q9CDS6_LACLA.Residues 1-60 are 68% similar to a (PROTEOME GLYCOSYLTRANSFERASE COMPLETE) protein domain (PD385229) which is seen in Q9CDS6_LACLA.Residues 232-297 are 41% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD000172) which is seen in Q9HRP8_HALN1.Residues 70-157 are 61% similar to a (PROTEOME COMPLETE BIOSYNTHESIS) protein domain (PD190085) which is seen in Q9CDS6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 10:00:34 2002","Fri Sep 8 12:19:03 2006","Fri Sep 8 12:19:03 2006","Thu Mar 14 13:44:51 2002","","Thu Mar 14 13:44:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1444 is paralogously related (blast p-value < 1e-3) to SMu1443, a predicted glucosyl transferase.","Thu Mar 14 13:44:51 2002","","No significant hits to the NCBI PDB database.","SMU.1589c","","Residues 148 to 313 (E-value = 3.3e-10) place SMu1444 in the Glycos_transf_1 family which is described as Glycosyl transferases group 1 (PF00534)","Thu Mar 14 13:44:51 2002","24379971","","","","","","1","","","SMU.1589c","306" "SMu1445","1522396","1520936","1461","ATGACAAATGAAACAATGATGCAGTATTTTGAATGGTATTTGCCAAACGATGGTAAGCATTGGCAGCATTTAGCTGAAGATGCCAGTCATCTTAAGAATATTGGGATTAGCAAAGTTTGGATGCCACCGGCTTTTAAAGGAACGGGTTCCAATGATGTTGGCTATGGCGTTTATGATCTTTATGATCTGGGTGAATTTAATCAAAATGGAACTGTCAGGACCAAGTATGGCAGCAGGGAAGATTATCTCAATGCTGTGAATGCTCTGAAGGAGCAGGAAATCATGCCTATTTCCGATATTGTCCTTAATCACAAGGCCAATGGTGATGCCAAAGAAAGATTTCAAGTGGTTAAAGTCAATCCCAGCAACCGTCAAGAAAAGATTTCTGAACCTTATGAGATTGAAGGTTGGACCCAGTTTAACTTTCCGGGTCGACAGGATAACTACAGCGATTTCAAATGGCATTGGTACCATTTCACTGGCGTTGATTATGACGCTCTTCATAATGAAAATGGTATCTACATGATCCTAGGTGATAACAAGGGTTGGGCCAGTCAGGAAAATATTGATCAGGAAAATGGTAATTATGATTACCTGATGTATGATGATATTGATTTTAAACATCCTGAAGTACAGGAGCACTTGCGAGATTGGGTTGCTTGGTTTTTGGAAACAAGTGGTGTCGGTGGTTTTCGTTTAGATGCTATTAAACATATTGATAAGACTTTTATGGCACAATTTATTCGTTATATTCGTGAGCATCTTAAAGCAGACCTTTATGTTTTTGGTGAGTACTGGAAAGACAGTCATTTCGATATTACCGATTATCTTCATAGTGTTGACCTGCAATTTGACCTGATTGATGTTATGCTGCACATGAGTCTCTTTGAGGCTGGTCAAAAAGGTTCTGATTTTGATTTGTCAACGATTTTAGACGATAGTCTGATGAAAAGCCATCCTGATTTTGCTGTTACTTTTGTTGATAATCATGATTCCCAAAGAGGGCAGGCTTTAGAGTCAACGGTTGCAGAGTGGTTTAAACCTTTAGCTTATGGTTTGATTTTGTTGCGTCAAGAGGGGATTCCTTGTGTCTTTTACGGTGATTACTATGGTATTTCGGGTGAATTTGCTCAGGAATCTTTCCAGACTGTTTTAGATAAACTGCTTTATATCAGGCAATACCATGTTTATGGATCGCAAGAAGATTATTTTGACTATGCCAATTGTATTGGCTGGACTTGTCTGGGAGATGAAGAGCATCCTGATGGTGTGGCTGTCATCATATCTAATGGGGAAGCTAATTGCAAACGAATGAATATGGGAGAATTTAATCGGAATAAGGTTTTTGTTGATTATCTTAATAATTGTACAGAAGAAGTGATTTTAGATGATCAAGGCTGGGGTGATTTTCCAGTTCAAGAAGCTTCCTTGTCAGCTTGGGTTAATAAAGATGCTCATTGA","4.50","-37.61","56447","MTNETMMQYFEWYLPNDGKHWQHLAEDASHLKNIGISKVWMPPAFKGTGSNDVGYGVYDLYDLGEFNQNGTVRTKYGSREDYLNAVNALKEQEIMPISDIVLNHKANGDAKERFQVVKVNPSNRQEKISEPYEIEGWTQFNFPGRQDNYSDFKWHWYHFTGVDYDALHNENGIYMILGDNKGWASQENIDQENGNYDYLMYDDIDFKHPEVQEHLRDWVAWFLETSGVGGFRLDAIKHIDKTFMAQFIRYIREHLKADLYVFGEYWKDSHFDITDYLHSVDLQFDLIDVMLHMSLFEAGQKGSDFDLSTILDDSLMKSHPDFAVTFVDNHDSQRGQALESTVAEWFKPLAYGLILLRQEGIPCVFYGDYYGISGEFAQESFQTVLDKLLYIRQYHVYGSQEDYFDYANCIGWTCLGDEEHPDGVAVIISNGEANCKRMNMGEFNRNKVFVDYLNNCTEEVILDDQGWGDFPVQEASLSAWVNKDAH","1520951","","intracellular a-amylase","Cytoplasm, Extracellular","Matches in gapped BLAST to intracellular a-amylase:residues 1-486 are 98% similar to the previously published enzyme in S.mutans (gi3023168). Residues 1-481 are 61% similar to intracellular a-amylase in S.bovis (gi450849) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0708 (0.0).","

InterPro
IPR002035
Domain

von Willebrand factor, type A
PR00453	$\"[305-322]T$ $\"[424-432]T$	VWFADOMAIN

InterPro
IPR006047
Domain

Glycosyl hydrolase, family 13, catalytic region
PF00128	$\"[4-392]T$	Alpha-amylase

InterPro
IPR006589
Domain

Glycosyl hydrolase, family 13, subfamily, catalytic region
SM00642	$\"[4-392]T$	Aamy

InterPro
IPR013776
Family

Alpha-amylase, thermostable
PIRSF001021	$\"[1-486]T$	Alph-amls_thrmst

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[3-400]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
PTHR10357	$\"[24-106]T$ $\"[147-480]T$	PTHR10357
PTHR10357:SF9	$\"[24-106]T$ $\"[147-480]T$	PTHR10357:SF9
SSF51011	$\"[395-483]T$	SSF51011
SSF51445	$\"[1-374]T$	SSF51445

","BeTs to 6 clades of COG0366COG name: GlycosidasesFunctional Class: GThe phylogenetic pattern of COG0366 is ----Y-VcEBR----------Number of proteins in this genome belonging to this COG is 4","***** PR00110 (Alpha-amylase signature) with a combined E-value of 9.4e-13. PR00110B 93-104 PR00110C 228-239 PR00110E 321-333","Residues 143-189 are identical to a (3.2.1.- A-AMYLASE INTRACELLULAR) protein domain (PD410860) which is seen in O68875_STRMU.Residues 1-142 are identical to a (ALPHA-AMYLASE HYDROLASE GLYCOSIDASE) protein domain (PD031991) which is seen in O68875_STRMU.Residues 380-483 are 92% similar to a (HYDROLASE GLYCOSIDASE ALPHA-AMYLASE) protein domain (PD005779) which is seen in O68875_STRMU.Residues 263-370 are identical to a (ALPHA-AMYLASE HYDROLASE GLYCOSIDASE SIGNAL PRECURSOR) protein domain (PD001604) which is seen in O68875_STRMU.Residues 149-249 are 66% similar to a (HYDROLASE ALPHA-AMYLASE GLYCOSIDASE PRECURSOR SIGNAL) protein domain (PD000173) which is seen in Q53786_STRBO.Residues 190-449 are 23% similar to a (TRANSFERASE DEXTRANSUCRASE) protein domain (PD186168) which is seen in Q55264_STRSL.Residues 258-312 are 47% similar to a (CARBOHYDRATE INTRACELLULAR METABOLISM) protein domain (PD385898) which is seen in Q53786_STRBO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 13:50:45 2002","Thu Mar 14 13:50:45 2002","Thu Jul 27 11:17:04 2006","Thu Mar 14 13:49:01 2002","Thu Mar 14 13:49:01 2002","Thu Mar 14 13:49:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1445 is paralogously related (blast p-value < 1e-3) to SMu0827,a predicted glucosyltransferase-S; SMu0806 and SMu0914, both predicted glucosyltransferase-I; SMu0915,a predicted glucosyltransferase-SI; and SMu1851, a predicted conserved hypothetical protein.","Mon Mar 18 09:58:07 2002","Thu Jul 27 11:17:04 2006","pdb1HVXA Chain A, Bacillus Stearothermophilus Alpha-Amylase 491 7e-140pdb1VJS Structure Of Alpha-Amylase Precursor 469 4e-133pdb1BLI Bacillus Licheniformis Alpha-Amylase 460 1e-130","SMU.1590c","","Residues 4 to 392 (E-value = 5.4e-70) place SMu1445 in the Alpha-amylase family which is described as Alpha amylase, catalytic domain (PF00128)","Thu Mar 14 13:49:01 2002","","","Simpson,C.L. and Russell,R.R.B.Intracellular alpha-amylase of Streptococcus mutansJ. Bacteriol. 180 (17), 4711-4717 (1998)PubMed: 9721315","Cotta,M.A. and Whitehead,T.R.Regulation and cloning of the gene encoding amylase activity of the ruminal bacterium Streptococcus bovisAppl. Environ. Microbiol. 59 (1), 189-196 (1993)PubMed: 7679887Whitehead,T.R. and Cotta,M.A.Development of a DNA probe for Streptococcus bovis by using acloned amylase geneJ. Clin. Microbiol. 31 (9), 2387-2391 (1993)PubMed: 7691873","Thu Mar 14 13:50:45 2002","Thu Mar 14 13:52:49 2002","1","","","SMU.1590c","72" "SMu1446","1523545","1522544","1002","ATGAACACAGATGACACAATCACTATTTATGATGTTGCCCGTGAAGCGGGAGTGTCCATGGCAACTGTCAGCCGTGTTGTGAATGGAAATAAAAATGTCAAAGAGAATACCCGCAAAAAAGTCCTAGAAGTCATTGACCGTCTTGATTATCGGCCAAATGCTGTGGCGCGTGGTTTGGCAAGTAAGAAAACGACTACGGTAGGTGTGGTTATCCCTAATATTGCTAATGCTTATTTTTCTATTTTAGCTAAGGGAATTGATGACATTGCAACCATGTATAAATATAATATTGTACTGGCTTCAAGTGATGAAGATGACGATAAGGAAGTCAATGTTATCAATACTTTATTTGCTAAACAGGTTGATGGTATTATTTTTATGGGACATCATTTAACTGAAAAAATTCGCGCTGAATTTTCACGAGCACGGACACCGGTTGTTTTATCAGGTACTGTAGATCTGGAGCATCAACTCCCCAGTGTTAATATTGATCATAGTAAGGCAGCACAAGATGCCGTAGCTTTATTGGCCAAACATCATGATAAGATTGCTTTTGTATCGGGTCCCCTTATTGATGATATCAATGGCAAGGTACGTCTGGCTGGTTATAAAGAAGGCCTGAAAAAGAAAGGATTGCCTTTCAAAGAAGGACTTGTTTTTGAAGCTCAATATAAGTATCAAGAAGGATATCAGTTAGCGCAGCGTGTCATTAATTCAGGCGCAACAGCTGCTTATGTTGCTGAGGATGAGTTGGCTGCTGGGCTGTTAAATGGTTTGTTTGCTGCTGGTAAGAAAGTCCCAGAAGACTTTGAAATTATCACGAGTAATGACTCTACTATTGCGCTTTATACTCGTCCTAATATGACATCTATCAGTCAGCCGATTTATGATTTAGGAGCAGTTGCTATGCGCATGTTAACAAAGATTATGAACAAGGAAGAATTGGAAGAAAAAGAAATTGTTCTTAATCATGGTATCAGAGAAAGAGGAACAACTAAATAG","6.90","-0.29","36601","MNTDDTITIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEVIDRLDYRPNAVARGLASKKTTTVGVVIPNIANAYFSILAKGIDDIATMYKYNIVLASSDEDDDKEVNVINTLFAKQVDGIIFMGHHLTEKIRAEFSRARTPVVLSGTVDLEHQLPSVNIDHSKAAQDAVALLAKHHDKIAFVSGPLIDDINGKVRLAGYKEGLKKKGLPFKEGLVFEAQYKYQEGYQLAQRVINSGATAAYVAEDELAAGLLNGLFAAGKKVPEDFEIITSNDSTIALYTRPNMTSISQPIYDLGAVAMRMLTKIMNKEELEEKEIVLNHGIRERGTTK","1522559","","catabolite control protein A","Cytoplasm","Matches in gapped BLAST to catabolite control protein A: residues 1-333 are 95% similar to a previously published enzyme in S.mutans (gi2323342), (gi2495405) and (gi2155300). Residues 1-333 are 84% similar to the protein from S.bovis(gi7328454).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0707 (1e-160).","

InterPro
IPR000843
Domain

Bacterial regulatory protein, LacI
PR00036	$\"[8-18]T$ $\"[18-28]T$	HTHLACI
PF00356	$\"[7-32]T$	LacI
SM00354	$\"[6-76]T$	HTH_LACI
PS00356	$\"[9-27]T$	HTH_LACI_1
PS50932	$\"[7-61]T$	HTH_LACI_2

InterPro
IPR001761
Domain

Periplasmic binding protein/LacI transcriptional regulator
PF00532	$\"[64-328]T$	Peripla_BP_1

InterPro
IPR006377
Family

Catabolite control protein A
TIGR01481	$\"[5-333]T$	ccpA

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[5-63]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[58-196]T$	G3DSA:3.40.50.2300
SSF53822	$\"[65-333]T$	SSF53822

","BeTs to 4 clades of COG1609COG name: Transcriptional regulators of the LacI familyFunctional Class: KThe phylogenetic pattern of COG1609 is ------V-EBrH---------Number of proteins in this genome belonging to this COG is 5","***** IPB000843 (Bacterial regulatory protein, LacI family) with a combined E-value of 8.1e-37. IPB000843A 8-28 IPB000843B 33-71","Residues 8-90 are 83% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000947) which is seen in Q48518_LACCA.Residues 91-142 are 75% similar to a (TRANSCRIPTION REGULATION DNA-BINDING) protein domain (PD329029) which is seen in Q48518_LACCA.Residues 68-125 are identical to a (TRANSCRIPTION REGULATION DNA-BINDING REPRESSOR) protein domain (PD353269) which is seen in CCPA_STRMU.Residues 280-333 are 96% similar to a (TRANSCRIPTION DNA-BINDING REGULATION TRANSCRIPTIONAL) protein domain (PD009758) which is seen in CCPA_STRMU.Residues 8-125 are 43% similar to a (TRANSCRIPTION REPRESSOR REGULATION) protein domain (PD023303) which is seen in Q9WWF6_AGRTU.Residues 143-277 are 89% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000591) which is seen in CCPA_STRMU.Residues 9-64 are 51% similar to a (DNA-BINDING TRANSCRIPTION REGULATION) protein domain (PD407822) which is seen in O87640_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 14:02:03 2002","Thu Mar 14 13:59:53 2002","Thu Feb 3 15:00:42 2005","Thu Mar 14 13:59:53 2002","Thu Mar 14 13:59:53 2002","Thu Mar 14 13:59:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1446 is paralogously related (blast p-value < 1e-3) to SMu1424, SMu1679 ,SMu0094 and SMu0807,all lacI family and related sugar operon repressors.","Thu Mar 14 14:02:03 2002","Thu Feb 3 15:00:42 2005","pdb1BDHA Chain A, Purine Repressor Mutant-Hypoxanthine-Palind... 123 4e-029pdb2PUEA Chain A, Crystal Structure Of The Laci Family Member... 122 8e-029pdb2PUAA Chain A, Crystal Structure Of The Laci Family Member... 121 1e-028","SMU.1591c","","Residues 7 to 32 (E-value = 4.8e-13) place SMu1446 in the LacI family which is described as Bacterial regulatory proteins, lacI family (PF00356)Residues 64 to 330 (E-value = 3.8e-09) place SMu1446 in the Peripla_BP_1 family which is described as Periplasmic binding proteins and sugar binding domain of the LacI family (PF00532)","Thu Feb 3 15:00:42 2005","","","Simpson,C.L. and Russell,R.R.Identification of a homolog of CcpA catabolite repressor protein in Streptococcus mutansInfect. Immun. 66 (5), 2085-2092 (1998)PubMed: 9573093Browngardt CM, Wen ZT, Burne RA.RegM is required for optimal fructosyltransferase and glucosyltransferase gene expression in Streptococcus mutans.FEMS Microbiol Lett. 2004 Nov;240(1):75-9.PMID: 15500982","van den Bogaard,P.T.C., Kleerebezem,M., Kuipers,O.P. and deVos,W.M.Control of Lactose Transport, beta-Galactosidase Activity, andGlycolysis by CcpA in Streptococcus thermophilus: Evidence forCarbon Catabolite Repression by a Non- Phosphoenolpyruvate- Dependent Phosphotransferase System SugarJ. Bacteriol. 182 (21), 5982-5989 (2000)PUBMED 11029416","Fri Sep 8 12:10:51 2006","Thu Mar 14 13:59:53 2002","1","","","SMU.1591c","305" "SMu1447","1523708","1524787","1080","ATGTCAAAATTAGCACAGATTGTTCAAAAACTCAAAAAGCAAGGTATTGAAGCTGCTGTCCTTTCAGATCCTGTCTCCATTAATTATTTAACAGGTTTTTATAGTGATCCGCATGAACGCCTTATGTTCCTCTTCCTCTTTGCAGATCAAGAACCTCTGCTTTTTTTACCTGAACTTGATGCTTTAAGAGCAAAAAGTATATTAGATATTTCGGTGACTGGCTATCTTGATTTTGAAAATCCTTTGGAAAAAATTAAGACCTTATTGCCTAAAACGAATTATTCTAAAATTGCCTTGGAATTTGACAACTTAAATGTAACGAAATTTAAGGGACTTGAAACAATTTTTTCAGGTCAATTCACCAACTTAACTCCTTTAATCAATCGTATGCGCCTGATTAAATCAGCTGACGAAATTCAAAAATTATTAATCGCTGGAGAGCTTGCAGACAAGGCTGTTCAAATTGGTTTTGATAGTATTTCCCTTAATGCCACAGAAACAGATATTATCGCTCAGATTGAATTTGAAATGAAAAAACTAGGCGTTGATAAAATGAGTTTTGAAACGATGGTATTAACAGGCAGTAACGCTGCCAATCCTCACGGCCTTCCAGCAAGTCACAAAATCGAAAACAATCATTTGCTGCTCTTTGATTTAGGTGTTGAAAGTACAGGCTATGTCAGTGATATGACACGAACTGTTGCTGTTGGCCAACCTGACCAGTTTAAAAAGGATATTTATAATATTTGCTTAGAAGCCCAATTAACAGCACTTGACTTCATCAAACCGGGAGTGAGTGCTGCTCAAGTGGATGCCGCAGCTCGTTCTGTTATCGAAAAGGCTGGCTATGGTGACTATTTCAACCATCGTCTCGGGCACGGCATCGGTATGGGACTGCATGAATTCCCATCTATTATGGCGGGAAATGATATGCTCCTAGAAGAAGGCATGTGTTTCTCTGTTGAGCCCGGCATTTACATTCCTGAAAAAGTTGGTGTTCGTATTGAAGATTGCGGTCATGTCACCAAAAATGGTTTTGAAGTCTTTACCCAAACGCCAAAAGAACTACTTTATTTCTAA","4.90","-12.19","39799","MSKLAQIVQKLKKQGIEAAVLSDPVSINYLTGFYSDPHERLMFLFLFADQEPLLFLPELDALRAKSILDISVTGYLDFENPLEKIKTLLPKTNYSKIALEFDNLNVTKFKGLETIFSGQFTNLTPLINRMRLIKSADEIQKLLIAGELADKAVQIGFDSISLNATETDIIAQIEFEMKKLGVDKMSFETMVLTGSNAANPHGLPASHKIENNHLLLFDLGVESTGYVSDMTRTVAVGQPDQFKKDIYNICLEAQLTALDFIKPGVSAAQVDAAARSVIEKAGYGDYFNHRLGHGIGMGLHEFPSIMAGNDMLLEEGMCFSVEPGIYIPEKVGVRIEDCGHVTKNGFEVFTQTPKELLYF","1524796","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP) and SMu1415 (pepM). ","proline dipeptidase","Cytoplasm","Residues 1-359 are 99% similar to PepQ a previously published sequence from S.mutans (gi2323341). Numerous matches in gapped BLAST to dipeptidase: residues 1-359 are 73% similar to gi15674617 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0706 (1e-154).","

InterPro
IPR000587
Domain

Creatinase
PF01321	$\"[3-133]T$	Creatinase_N

InterPro
IPR000994
Domain

Peptidase M24, catalytic core
G3DSA:3.90.230.10	$\"[130-356]T$	Peptidase_M24_cat_core
PTHR10804	$\"[178-355]T$	Peptidase_M24_cat_core
PF00557	$\"[140-351]T$	Peptidase_M24

InterPro
IPR001131
Domain

Peptidase M24B, X-Pro dipeptidase, cataltyic core
PS00491	$\"[289-301]T$	PROLINE_PEPTIDASE

InterPro
IPR001714
Family

Peptidase M24, methionine aminopeptidase
PR00599	$\"[191-204]T$ $\"[213-229]T$ $\"[311-323]T$	MAPEPTIDASE

noIPR
unintegrated

unintegrated
PTHR10804:SF16	$\"[178-355]T$	PTHR10804:SF16
SSF53092	$\"[7-133]T$	SSF53092
SSF55920	$\"[132-359]T$	SSF55920

InterPro
IPR002726
Family

Protein of unknown function DUF46
PF01864	$\"[1-165]T$	DUF46

noIPR
unintegrated

unintegrated
SSF103473	$\"[38-120]T$	SSF103473

","BeTs to 4 clades of COG0575COG name: CDP-diglyceride synthetaseFunctional Class: IThe phylogenetic pattern of COG0575 is amtkyqvcEbrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 31-165 are 29% similar to a (CYTIDYLYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD016601) which is seen in O58081_PYRHO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:22:16 2002","Fri Jan 3 15:39:00 2003","Fri Jan 3 15:39:00 2003","Thu Mar 14 14:16:50 2002","","Thu Mar 14 14:16:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1448 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 14:16:50 2002","","No significant hits to the NCBI PDB database.","SMU.1593c","","Residues 1 to 165 (E-value = 1.9e-06) place SMu1448 in the DUF46 family which is described as Putative integral membrane protein DUF46 (PF01864)","Thu Mar 14 14:16:50 2002","24379975","","","","","","1","","","SMU.1593c","" "SMu1450","1526356","1525586","771","ATGAAAAAGAAATTTATTTATCTTACTGTCCTTGTGGTTGTAGCGGTATTTTGCATAAGCACATTCTTGACATTAAAAGGAGATTCGCAGGATCGCGAAGCACATTGGAGTTATTCAGGCAGCACATCACCTGAACATTGGGGAGATTTATCAGATGATTATAAGGCTGCTAAAGATGGTAAGGAACAGTCACCAATCAATATCACTGGTGCCAAAGATGTTGACCTACCTTCCCTACAATTAAACAGTAAAAATTCCAAGGCTGAAGTAGAAAATAATGGTCATACCATCGAAGTTAAGTTAAAAAATAAGAAAAATACGCTGAAATTTAATGGGAAAACTTATACACTTGAACAATTCCATTTTCATGCGCCAAGTGAAAATCAAATTGATGGGAAAACCTACCCTTTGGAAGGTCATTTTGTTTACACAACAAAAGATAAGAAAATCACTGTCATATCTATTCTCTATCAGTATGGAAAAGAAAATAAAACCTTAAAGCAAGTTTGGAAGAAAATGCCTCAAAAGGCAGAGACAAAAAAGAACCTATCTCAACCTGTTGCTATCAGTCAATTATTCCCTAAAGATTTGGATTACTATAATTTTGAGGGTTCTTTGACGACACCGCCTTGTACAGAAGGGGTTAATTGGATTGTCTTTAAAAAGCAAGAAAATATCAGCAAGGCTCAAGTGAAAAAATTCTCGAAAACGCTTGGATTCAACAACAATCGACCTATTCAAAAATTAAATGGGCGTGAGATTAAAGAGTAG","9.70","6.58","18541","MKKKFIYLTVLVVVAVFCISTFLTLKGDSQDREAHWSYSGSTSPEHWGDLSDDYKAAKDGKEQSPINITGAKDVDLPSLQLNSKNSKAEVENNGHTIEVKLKNKKNTLKFNGKTYTLEQFHFHAPSENQIDGKTYPLEGHFVYTTKDKKITVISILYQYGKENKTLKQVWKKMPQKAETKKNLSQPVAISQLFPKDLDYYNFEGSLTTPPCTEGVNWIVFKKQENISKAQVKKFSKTLGFNNNRPIQKLNGREIKE","1526107","message from Dragana:3. SMU.1595 also has a frame shift. ORFs SMU.1594 and 1595 should be one ORF (carbonic anhydrase). This sequence should be also resequenced.","carbonic anhydrase (carbonate dehydratase)","Extracellular, Periplasm","Limited matches in gapped BLAST to carbonic anhydrase:residues 35- 149 are 47% similar to(gi|4139721|),(gi|4139722|),(gi|5915870|) and (gi|1841441|) as seen in N.gonorrhoeae . SMu1450 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001148
Family

Carbonic anhydrase, eukaryotic
PD000865	$\"[43-151]T$	Q8CVC3_STRMU_Q8CVC3;
G3DSA:3.10.200.10	$\"[33-151]T$	no description
PTHR18952	$\"[93-148]T$	CARBONIC ANHYDRASE
PF00194	$\"[36-123]T$	Carb_anhydrase
PS51144	$\"[34-163]T$	ALPHA_CA_2
PS00162	$\"[126-142]?$	ALPHA_CA_1

noIPR
unintegrated

unintegrated
PTHR18952:SF2	$\"[93-148]T$	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE)
signalp	$\"[1-20]?$	signal-peptide
tmhmm	$\"[5-25]?$	transmembrane_regions

","No hits to the COGs database.","***** IPB001148 (Eukaryotic-type carbonic anhydrase) with a combined E-value of 1.4e-23. IPB001148A 58-68 IPB001148B 89-104 IPB001148C 113-145","Residues 36-149 are 47% similar to a (CARBONIC ANHYDRASE LYASE DEHYDRATASE) protein domain (PD000865) which is seen in CAH_NEIGO.Residues 36-149 are 34% similar to a (CARBONIC PROTEOME COMPLETE ANHYDRASE) protein domain (PD298088) which is seen in Q9ZK30_HELPJ.","","Thu Nov 29 19:04:24 2001","Thu Nov 29 19:04:24 2001","Thu Nov 29 19:04:24 2001","Thu Nov 29 19:04:24 2001","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","Thu Nov 29 19:04:24 2001","Thu Nov 29 19:04:24 2001","","Thu Mar 14 14:26:49 2002","Wed Oct 23 11:51:32 2002","Thu Oct 17 11:15:39 2002","Mon Dec 3 12:44:20 2001","Mon Dec 3 12:44:20 2001","Mon Dec 3 12:44:20 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1450 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 14:34:38 2002","Mon Dec 3 12:44:20 2001","pdb|1KOQ|B Chain B, Neisseria Gonorrhoeae Carbonic Anhydrase 127 6e-031pdb|1KOQ|A Chain A, Neisseria Gonorrhoeae Carbonic Anhydrase 127 6e-031pdb|1KOP|A Chain A, Neisseria Gonorrhoeae Carbonic Anhydrase >g... 127 6e-031","SMU.1595c","Thu Nov 29 19:04:24 2001","No significant hits to the Pfam 11.0 database","Mon Dec 3 12:44:20 2001","","","","Soltes-Rak,E., Mulligan,M.E. and Coleman,J.R.Identification and characterization of a gene encoding avertebrate-type carbonic anhydrase in cyanobacteriaJ. Bacteriol. 179 (3), 769-774 (1997)PubMed: 9006032","","Mon Mar 18 09:54:05 2002","1","","","SMU.1595c","" "SMu1451","1527980","1526622","1359","ATGGATGAACAAAAAGGATTATTTGGTTTCCTAGATAAATATTTGATGGGACCGATGAGCATTATTGCTCAATATAAAGTTGTACGCGCTATTACAGCAGCGGGTATGGCTGTTGTTCCTTTTACCATTGTTGGTTCAATGGTTTTGGTTTTTAGTGTTTTACCGATATCGTTTTCTTTCTTGCCTATTGTCAAAGATATTTTTGCAGCTTCCTTTGATAAGTTTACTGCCTTATATATGATTATTAATTATGCAACTATGGGTTCCTTGTCGCTTTACTTTGTTCTAACTATGGGTTATGAGTTAACCAAAATTTATGCAGAAGAAGAGGAACTAAATATGAATCCTCTAAACGGGGCTCTGCTGTCATTATTCGCTTTTATCATGACTGTTCCACAAATTGTTTTTAATAATGGTTCCATGTCATCTGTGACAACTCTTAAAAAAGGAGCAGTTACTGTAGATGGCTGGGCAATGAGTAATGGTGTTACTCGATTTGGCACAACAGGGATTTTTACTGCTATTATCATGGGAATATTAACAGTTCTTCTTTATCGTCTATGTATAAAACGCAATTGGGTAATAAAAATGCCAGAAGCGGTACCAGAAGGGGTCTCTCGAGGTTTTTCAGCTTTAATCCCTGGTTTTGTCATTGCATTTGTTGTTATATTTATTGATGGTATCTTTATTTTTCTAGGAACTGATATTTTTGAAGCCATATCTATTCCATTTAGTTTTGTTAGAAACTTAACTGGAACATGGATTGGTATTATGATTATTTATCTTCTAACCCAAGCACTTTGGATTGTTGGGATTCATGGCGCTAATATTATCTTTGCTTTTGTTAATCCAATTGCTCTTGCTAATATGGCAGAAAATGCTAAGGGAGCTCATTATATTGTTGCAGGTGAATGGTCCAATATGTTTGTTATCGCTGGTGGATCTGGTGCAACTCTTGGACTTTGTATTTGGTTAGCAACTCGTTCTAAGTCTGAACAATTGAATGCTATTGGTAAAGCATCTGTTGTACCAGCTATTTTCAATATTAATGAACCTTTAATTTTTGGTATTCCAATTATCTATAACCCAGCACTTGCTATTCCATTTATTTTAGCACCAATGACTTCTGCAACCCTTTATTATTTAGCAATGAAATTAGATTTGATTAAGGCAGTTTTTGCCAATGTTCCATGGCCAACACCGGTTGGTATTGGTGCTTTTATTGGTACAGGAGATTGGAAATCTGTCATTTTAGCTCTAATTTGTGCTGTAGCTGCTTTTCTTGTCTATTATCCATTCATTAGAAATTATGATAGAAAACTAGTCAAAGAAGAACGGGAAGCTTCAGCAATTGCTTAA","8.30","2.34","49235","MDEQKGLFGFLDKYLMGPMSIIAQYKVVRAITAAGMAVVPFTIVGSMVLVFSVLPISFSFLPIVKDIFAASFDKFTALYMIINYATMGSLSLYFVLTMGYELTKIYAEEEELNMNPLNGALLSLFAFIMTVPQIVFNNGSMSSVTTLKKGAVTVDGWAMSNGVTRFGTTGIFTAIIMGILTVLLYRLCIKRNWVIKMPEAVPEGVSRGFSALIPGFVIAFVVIFIDGIFIFLGTDIFEAISIPFSFVRNLTGTWIGIMIIYLLTQALWIVGIHGANIIFAFVNPIALANMAENAKGAHYIVAGEWSNMFVIAGGSGATLGLCIWLATRSKSEQLNAIGKASVVPAIFNINEPLIFGIPIIYNPALAIPFILAPMTSATLYYLAMKLDLIKAVFANVPWPTPVGIGAFIGTGDWKSVILALICAVAAFLVYYPFIRNYDRKLVKEEREASAIA","1526638","For other 'lac' genes see SMu0104 (lacD); SMu0793 (lacR); SMu0794 (lacC); SMu0094 (lacI); SMu1359 (lacC);SMu1354 (lacX); SMu1355 (lacG); SMu1356 (lacE);SMu1358 (lacD);SMu1360 (lacB); SMu1361 (lacA) and SMu1362 (lacR). ","PTS system, cellobiose-specific IIC component","Membrane, Cytoplasm","Matches in gapped BLAST to PTS system, sugar-specific IIC component:residues 28-450 are 28% similar to the previously published protein in S.mutans (gi:433809),(gi:1709898). Residues 1-446 are 72% similar to the enzyme from S.pneumoniae(gi:15900243). This sequence is similar to Spy2050.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0330 (3e-49).","

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[32-373]T$	PTS_EIIC

InterPro
IPR004501
Domain

Phosphotransferase system, lactose/cellobiose IIC component
TIGR00410	$\"[15-447]T$	lacE
PS51105	$\"[11-433]T$	PTS_EIIC_TYPE_3

","BeTs to 3 clades of COG1455COG name: Phosphotransferase system cellobiose-specific component IICFunctional Class: GThe phylogenetic pattern of COG1455 is --------eB------o----Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 175-447 are 38% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD006461) which is seen in O50980_BORBU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 3 14:22:49 2007","Thu Sep 28 10:16:57 2006","Fri Mar 31 12:22:40 2006","Thu Mar 14 14:41:32 2002","","Fri Dec 21 16:29:27 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1451 is paralogously related (blast p-value < 1e-3) to SMu1356,a predicted PTS system, lactose-specific component IIBC; SMu0159,a predicted hypothetical protein (possible PTS system component) and SMu1677, a predicted PTS system, sucrose-specific IIABC component.","Thu Mar 14 14:46:16 2002","","No significant hits to the NCBI PDB database.","SMU.1596c","","Residues 32 to 373 (E-value = 4.4e-77) place SMu1451 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)","Fri Dec 21 16:29:27 2001","","","Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337Rosey EL, Stewart GC.Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans.J Bacteriol. 1992 Oct;174(19):6159-70.PMID: 1400164Honeyman AL, Curtiss R.Isolation, characterization and nucleotide sequence of the Streptococcus mutans lactose-specific enzyme II (lacE) gene of the PTS and the phospho-beta-galactosidase (lacG) gene.J Gen Microbiol. 1993 Nov;139(11):2685-94.PMID: 8277252","Lai,X. and Ingram,L.O.Cloning and sequencing of a cellobiose phosphotransferase systemoperon from Bacillus stearothermophilus XL-65-6 and functionalexpression in Escherichia coliJ. Bacteriol. 175 (20), 6441-6450 (1993)PubMed: 8407820","Fri Mar 31 12:22:40 2006","Thu Mar 14 14:42:55 2002","1","","","SMU.1596c","" "SMu1452","1528514","1527996","519","ATGTGTCATCAATTAAGTAAAAAAACCAAAAAAGCTCTTGATCAAGAATTGAAACGAAAGACGACCTTAAAAAATAATTTATTTTCTCGTTATCTGCTTTTTAGATATAGTTTGGCTCTATTTTTCTTTGTCAATCTTTATTGGACATTTCCTCTCATTTATAAGCCAAGTGTCTATGTTATTTTGCCAGTGAGTTTGTTAATACTAATTGTTTTAGCTTGTGCTGAACAATTTAAACTATATAGCCTTCAAGAAGTTTATTTGAGAAATACTGAACGGGTTTTCAAGACTCAAATAGTTGTTCAAATTTTATTATTAATCATCAACATTTTTCCTCAACAATTATCAGTGGCTATTCCTTTCTTTTCAAATAATATGGCAGCACATGTATTTCTTGCTGTATTTCAATTTTTGGGTTTGTTTATTTGCTGGTATAATCTTAAACGTATCAAACAAATCAAGAATAATGAAGACAAATTTTATAATCGTTTTTACAACCATATTGAAAAGTATATTTAA","10.60","14.56","20683","MCHQLSKKTKKALDQELKRKTTLKNNLFSRYLLFRYSLALFFFVNLYWTFPLIYKPSVYVILPVSLLILIVLACAEQFKLYSLQEVYLRNTERVFKTQIVVQILLLIINIFPQQLSVAIPFFSNNMAAHVFLAVFQFLGLFICWYNLKRIKQIKNNEDKFYNRFYNHIEKYI","1528012","","conserved hypothetical protein","Membrane, Cytoplasm","Only matches to hypothetical protein in gapped BLAST:residues 5-164 are 31% similar to gi|15900242| in S.pneumoniae SMu1452 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-75]?$	signal-peptide
tmhmm	$\"[28-48]?$ $\"[58-78]?$ $\"[99-121]?$ $\"[127-147]?$	transmembrane_regions

InterPro
IPR003188
Family

Phosphotransferase system, lactose/cellobiose-specific IIA subunit
PD007286	$\"[11-100]T$	Ptrans_IIA
G3DSA:1.20.58.80	$\"[1-102]T$	PTS_IIA_lac
PIRSF000699	$\"[4-102]T$	PTS_IILac_III
PF02255	$\"[7-102]T$	PTS_IIA
PS51095	$\"[4-102]T$	PTS_EIIA_TYPE_3
SSF46973	$\"[1-102]T$	Ptrans_IIA

","BeTs to 3 clades of COG1447COG name: Phosphotransferase system cellobiose-specific component IIAFunctional Class: GThe phylogenetic pattern of COG1447 is --------eB------o----Number of proteins in this genome belonging to this COG is 2","***** IPB003188 (PTS system, Lactose/Cellobiose specific IIA subunit) with a combined E-value of 5.6e-31. IPB003188A 4-39 IPB003188B 50-91","Residues 4-102 are 46% similar to a (COMPONENT SYSTEM IIA PHOSPHOTRANSFERASE) protein domain (PD007286) which is seen in PTCA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 31 12:18:30 2006","Mon Feb 27 13:11:22 2006","Fri Mar 31 12:18:30 2006","Thu Mar 14 14:51:24 2002","Thu Mar 14 14:51:24 2002","Thu Mar 14 14:51:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1453 is paralogously related (blast p-value < 1e-3) to SMu1357, a predicted phosphotransferase system enzyme II.","Thu Mar 14 14:57:43 2002","Mon Feb 27 13:11:22 2006","pdb1E2AA Chain A, Enzyme Iia From The Lactose Specific Pts Fr... 84 5e-018","SMU.1598c","","Residues 7 to 102 (E-value = 1.7e-35) place SMu1453 in the PTS_IIA family which is described as PTS system, Lactose/Cellobiose specific IIA subunit (PF02255)","Thu Mar 14 14:51:24 2002","","","Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337","Breidt,F. Jr., Hengstenberg,W., Finkeldei,U. and Stewart,G.C. Identification of the genes for the lactose-specific components of the phosphotransferase system in the lac operon of Staphylococcus aureus J. Biol. Chem. 262 (34), 16444-16449 (1987) PubMed: 2824493 Stuber,K., Deutscher,J., Sobek,H.M., Hengstenberg,W. and Beyreuther,K. Amino acid sequence of the amphiphilic phosphocarrier protein factor IIILac of the lactose-specific phosphotransferase system of Staphylococcus Biochemistry 24 (5), 1164-1168 (1985) PubMed: 4096897 de Vos,W.M., Boerrigter,I., van Rooyen,R.J., Reiche,B. and Hengstenberg,W. Characterization of the lactose-specific enzymes of the phosphotransferase system in Lactococcus lactis J. Biol. Chem. 265 (36), 22554-22560 (1990) PubMed: 2125052 ","Fri Mar 31 12:18:30 2006","Thu Mar 14 14:57:43 2002","1","","","SMU.1598c","" "SMu1454","1530836","1528845","1992","GTGTTACATAAAAAAGAGACGCAAATTATCCAACTTTTGATTAAGGATGAGGGACAATTTATCACCAGTAAGGCATTAGCAGAACAGTTAAATTGTTCAGACAGGACGATTAGGACTTACTGCAAATTGTTGTCTGAGAAATTAAAGGACTATTCTGGTGTTGATATCATTTCTAAACAAGGTCAAGGCTATCAGTTCAATATTAAGGACAGAGAAAAGTATCTTCATTTTCTTGAAGACAATCATATCAATGATCACTTATTAACCTATAAGAAGGTCATTGATATTAATGACCGTTACAATTATTTGCTAAATAAGCTGCTATTTGAGCAAAATGAAATCTATTTTGATGACTTGGCGGATGAACTCTTTGTCAGCCGTTCTACTTTATCAAATGATTTTAAAAAAATAAGGAAACGCTTTGTTCCTTATCATTTAAAGATTGAAAGCAAGGCCAATAAAGGTGTTTTTGTGACAGGAACTGAACGTGACAAAAGACGCTTTATCATGGACTATTTCATTCATTCTGGTTTTATTAATACGATGCAGACCTATATTGACAATGAGCTGCTAAATCAGAAAATTTCTTTTGAAGAATTAACCATTATTGTTCTTGATGAGTGCCGTGAAGGTCATCTAAAGCTTTCAGATTTTGTGATTCAAAATTTGGTTATTCACATTGCTTTAGCGATTAGAAGGATAACGGAAGGCTTTCATATTGCCAAAATTTCAGATAAAACGGAGTTGAGCAATATGCCCGAAAGAGAAGTGGCCAGAAAAATTCTTAAACGGGTGACGCTGGCAACGCAGATTGAATTTCCAATAGAAGAGGTTGATTATATCACCCTGCATCTCATTTCAAAAAGCTATAATAATGCTCATTACATTTCAAATGACAATTTTGAGCAGATCCGTAAAGAGCTCGTCATGGCTATTGAGCAGCTTGAGCCCTGTTTGAAAAATGATTTTCAATTTATTGAAGGCCTGCTGGCACATCTTTCAACCATGCTTATTCGTTTGGAAGGTCAGATTAATTTAGAAAATCCTTTAACAGCAGAAATTCAAAAGAATTATCAGGTGAAATATCAATTAGCCCAAAAGTTAATGCACAGCATGCCGATTTTCAGTCCTTTTTCTTTCTCTGCAGATGAAATTGCCTATATTGCTCTGCATTTTATGGCAGCTACAGAAAGGCTCAAAGAAAAGAATAAGCATAATATTTTGGTCATTTGTGCTACTGGCTATGGTAGTGCTCAAATGCTGAAAAACCGAATTGAAAATGAACTGGGAAATCTGGTTCATATCACGGATGTTGTTGGTTACTATGATATCAATGATGATAAGCTGAAAGATATTGATTTCATTATTTCTTCTATTGACCTCTCTAATCTGATATTTAATATTCCTGTTTTCACAGTTTCGGTTTTCTTGACAGAAGAGGAATTAAGTCGAATTAGACATGGTATTGCCCATATAGAAGCTTCCCCAACGGAGTTAGCGCCTGTTGGAGTTTCTCCTGCTGATTTATCATCTGATTTTGATCATTATTTTTCAAAAGATGCTTTTTTGCAACTGTCAGATGTTAGTAAAGAAGAAGTGCTAAAAAAGATGATTCTTAGTATTTCAAAAGGGGAAAAGAGTCATTTTGCTGACAAGATGGAAGAATTAATTTATCAGCGTGAGGCAATGAGCTCGGTGGTTTTCAGCGATACTATTGCTGTACCGCATCCGATAAAAGCAGTAGGCAACAGACATCACATAGCAGTAGCCATGATAAAAGATGGTCTGTTTTGGAATCAGGATTATCCCAAAATGAAACTGGTCTTTTTAACATCAATGTCTATTTATGACAATGATGGTTTACCCGAATTAGCTTCTTGCATTGCAACTTTGGTTGATCGACCAGATATTCAGCAAAAGATGCTGACTTGTCAATCATTTGAACAATTTAAAAAGTTATTTTTAAAACTAGAAGAAAAGGAAAAAGGTTGA","6.30","-9.72","76707","MLHKKETQIIQLLIKDEGQFITSKALAEQLNCSDRTIRTYCKLLSEKLKDYSGVDIISKQGQGYQFNIKDREKYLHFLEDNHINDHLLTYKKVIDINDRYNYLLNKLLFEQNEIYFDDLADELFVSRSTLSNDFKKIRKRFVPYHLKIESKANKGVFVTGTERDKRRFIMDYFIHSGFINTMQTYIDNELLNQKISFEELTIIVLDECREGHLKLSDFVIQNLVIHIALAIRRITEGFHIAKISDKTELSNMPEREVARKILKRVTLATQIEFPIEEVDYITLHLISKSYNNAHYISNDNFEQIRKELVMAIEQLEPCLKNDFQFIEGLLAHLSTMLIRLEGQINLENPLTAEIQKNYQVKYQLAQKLMHSMPIFSPFSFSADEIAYIALHFMAATERLKEKNKHNILVICATGYGSAQMLKNRIENELGNLVHITDVVGYYDINDDKLKDIDFIISSIDLSNLIFNIPVFTVSVFLTEEELSRIRHGIAHIEASPTELAPVGVSPADLSSDFDHYFSKDAFLQLSDVSKEEVLKKMILSISKGEKSHFADKMEELIYQREAMSSVVFSDTIAVPHPIKAVGNRHHIAVAMIKDGLFWNQDYPKMKLVFLTSMSIYDNDGLPELASCIATLVDRPDIQQKMLTCQSFEQFKKLFLKLEEKEKG","1528861","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0891 (bglB); SMu0892 (bglB); SMu0893 (bglC); SMu0895 (bglA); SMu1007 (bglC); SMu1285 (bglC) and SMu1456 (bglA).For other 'lic' genes see SMu0888 (licT); SMu0889(licT); SMu1453 (licA) and SMu1455 (licB).","transcriptional regulator, required for cellobiose uptake and metabolism","Cytoplasm","This sequence corresponds weakly to the previously sequenced gi:4928283 and gi:11356487 in GenBank, predicted sorbitol operon regulators.Numerous hits in gapped BLAST to transcriptional regulator (antiterminator): residues 1-646 are 44% similar to gi:15902323 from S.pneumoniae.This sequence is similar to Spy1325. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1801 (2e-14).","

InterPro
IPR002178
Domain

Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
PD001689	$\"[523-646]T$	P71012_BACSU_P71012;
G3DSA:3.40.930.10	$\"[514-661]T$	no description
PS51094	$\"[514-657]T$	PTS_EIIA_TYPE_2

InterPro
IPR007737
Domain

M trans-acting positive regulator
PF05043	$\"[102-173]T$	Mga

InterPro
IPR011608
Domain

PRD
PF00874	$\"[201-288]T$ $\"[309-395]T$	PRD

InterPro
IPR013011
Domain

Phosphotransferase system, EIIB component, type 2
PS51099	$\"[405-497]T$	PTS_EIIB_TYPE_2

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[5-65]T$	HTH_11

noIPR
unintegrated

unintegrated
G3DSA:1.10.1790.10	$\"[209-292]T$ $\"[293-392]T$	no description

","BeTs to 3 clades of COG1762COG name: Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)Functional Class: G,TThe phylogenetic pattern of COG1762 is --------EB-H--gPOLIN-Number of proteins in this genome belonging to this COG is 4","***** IPB001550 (Transcriptional antiterminators bglG family) with a combined E-value of 2e-09. IPB001550B 326-360 IPB001550C 377-395 IPB001550C 270-288","Residues 354-429 are 40% similar to a (REGULATOR PROTEOME COMPLETE) protein domain (PD024189) which is seen in P96574_BACSU.Residues 2-360 are 20% similar to a (REGULATOR DEOR) protein domain (PD321515) which is seen in Q9F8B7_STRAG.Residues 9-194 are 25% similar to a (SORBITOL REGULATOR OPERON) protein domain (PD305356) which is seen in Q9X672_STRMU.Residues 523-646 are 28% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIA ENZYME COMPLETE) protein domain (PD001689) which is seen in P71012_BACSU.Residues 2-166 are 33% similar to a (PROTEOME COMPLETE YJDC REGULATION) protein domain (PD339335) which is seen in CELR_BACSU.Residues 198-348 are 27% similar to a (PROTEOME COMPLETE YJDC REGULATION) protein domain (PD039485) which is seen in CELR_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 31 12:15:39 2006","Mon Feb 27 12:46:24 2006","Fri Mar 31 12:15:39 2006","Thu Mar 14 15:00:28 2002","Thu Mar 14 15:00:28 2002","Thu Mar 14 15:00:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1454 is paralogously related (blast p-value < 1e-3) to SMu0279, SMu0260, and SMu0889, all predicted transcriptional regulators.","Thu Mar 14 15:05:06 2002","","No significant hits to the NCBI PDB database.","SMU.1599c","","Residues 194 to 288 (E-value = 1.2e-10) place SMu1454 in the PRD family which is described as PRD domain (PF00874)Residues 298 to 395 (E-value = 4.3e-11) place SMu1454 in the PRD family which is described as PRD domain (PF00874)","Mon Feb 27 12:46:24 2006","","","Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337Cote CK, Honeyman AL.The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549","Declerck N, Minh NL, Yang Y, Bloch V, Kochoyan M, Aymerich S.RNA recognition by transcriptional antiterminators of the BglG/SacY family: mapping of SacY RNA binding site.J Mol Biol. 2002 Jun 21;319(5):1035-48.PMID: 12079345","Fri Mar 31 12:15:39 2006","Thu Oct 24 09:21:59 2002","1","","","SMU.1599c","" "SMu1455","1531198","1530881","318","ATGGCAAAACAAGCTTTAATTATTTGCGCAGGCGGCATGTCATCATCAATGATTGCTAAAAAGACGATGGCCCTTCTTCAAGAACAAGGTGAAGACATTGAAATGGATGCGGTGGGTGTTCCAGAAGGGCAAAAACGCATTGAAGCAGACAACTATGACCTCTACCTTGTTAGCCCTCAAACAAAAATGAATTTTAAACAGTTGGCTGATGCAGCTGCTAAGAAAGATAAACCTATTGTTCAAATTCCACCACAAGCCTACGTTCCAATCCCAATGGGTATTGAAAAAATGGCTAAGTTGGTTAAAGAAAATATCTAG","6.70","-0.06","11462","MAKQALIICAGGMSSSMIAKKTMALLQEQGEDIEMDAVGVPEGQKRIEADNYDLYLVSPQTKMNFKQLADAAAKKDKPIVQIPPQAYVPIPMGIEKMAKLVKENI","1530897","For other 'lic' genes see SMu0888 (licT); SMu0889(licT); SMu1453 (licA) and SMu1454 (licR).","PTS system IIB component, required for cellobiose uptake and metabolism","Cytoplasm, Periplasm","Matches in gapped BLAST to phosphotransferase system sugar-specific EII component:residues 1-105 are 61% similar to the previously published protein in S.mutans (gi:433809) and (gi:1709898). Residues 1-105 are 61% similar to the enzyme from S.pneumoniae (gi:15900238). This sequence is weakly similar to Spy1324.SMu1455 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003501
Domain

Phosphotransferase system, lactose/cellobiose-specific IIB subunit
PF02302	$\"[4-103]T$	PTS_IIB

InterPro
IPR013012
Domain

Phosphotransferase system, EIIB component, type 3
PS51100	$\"[2-105]T$	PTS_EIIB_TYPE_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.270	$\"[3-87]T$	G3DSA:3.40.50.270
SSF52794	$\"[2-90]T$	SSF52794

","BeTs to 3 clades of COG1440COG name: Phosphotransferase system cellobiose-specific component IIBFunctional Class: GThe phylogenetic pattern of COG1440 is --------eB------o----Number of proteins in this genome belonging to this COG is 1","***** IPB003501 (Lactose/Cellobiose specific IIB subunit) with a combined E-value of 9.5e-06. IPB003501A 7-28 IPB003501B 53-79 IPB003501A 6-27","Residues 6-87 are 31% similar to a (COMPONENT SYSTEM IIB CELLOBIOSE-SPECIFIC) protein domain (PD012493) which is seen in Q9KSH5_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 31 12:09:28 2006","Mon Feb 27 11:27:34 2006","Fri Mar 31 12:09:28 2006","Thu Mar 14 15:42:21 2002","Thu Mar 14 15:42:21 2002","Thu Mar 14 15:42:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1455 is paralogously related (blast p-value < 1e-3) to SMu1356, a predicted PTS system, lactose-specific component IIBC.","Thu Mar 14 15:42:21 2002","","No significant hits to the NCBI PDB database.","SMU.1600c","","Residues 4 to 103 (E-value = 7.3e-21) place SMu1455 in the PTS_IIB family which is described as PTS system, Lactose/Cellobiose specific IIB subunit (PF02302)","Thu Mar 14 15:42:21 2002","","","Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337","de Vos,W.M.,Boerrigter,I.,van Rooyen,R.J.,Reiche,B.and Hengstenberg,W. Characterization of the lactose-specific enzymes of the phosphotransferase system in Lactococcus lactis J. Biol. Chem. 265 (36), 22554-22560 (1990) PubMed: 2125052 ","Fri Mar 31 12:09:28 2006","Thu Mar 14 15:43:49 2002","1","","","SMU.1600c","" "SMu1456","1532863","1531430","1434","ATGTCTAAATTACCTGAAAATTTTCTCTGGGGCGGTGCGGTTGCTGCCCATCAGCTAGAAGGCGGTTGGCAAGAAGGAGGCAAGGGAATTTCTGTTGCTGATGTCATGACTGCTGGTCGGCACGGCGTTGCGCGTGAAATCACAGCCGGTGTTCTAGAAGGTAAGTATTATCCTAACCATGAAGCCATTGATTTTTATCATCACTATAAAGAAGATGTCAAATTGTTTGCCGAAATGGGCTTCAAATGTTTTCGGACTTCCATCGCTTGGACACGGATTTTTCCTAAGGGAGATGAAGCAGAGCCTAATGAAGCAGGTCTGCAATTTTATGATGACCTTTTTGATGAATGTCTGAAATATGGTATTGAACCCGTTGTGACCCTATCGCATTTTGAATTGCCTTATCACCTTGTTACCGAATATGGTGGCTTTACTAACCGAAAAGTAATTGATTTCTTTGTTCATTTTGCTGAAGTTTGCTTTCGTCGTTATAAGGATAAGGTTAAGTATTGGATGACTTTCAACGAAATCAATAACCAAGCCAATTATCAAGAAGATTTTGCACCTTTTACTAATTCGGGGATTGTTTACAAAGAGGGAGATGACCGCGAAGCGATTATGTACCAAGCTGCTCATTATGAACTGGTAGCTTCTGCGCGTGCCGTTAAAATTGGTCATGCGATTAATCCCAATCTCAATATTGGGTGCATGGTTGCCATGTGTCCAATTTATCCAGCAACCTGTAACCCTAAAGATATCCTCATGGCTCAAAAAGCTATGCAAAAGCGTTATTACTTTGCGGATGTTCATGTCCATGGTTTTTATCCAGAACATATTTTCAAGTATTGGGAACGCAAGGCTATTAAGGTTGATTTTACTGAGCGAGATAAGAAGGATTTGTTTGAAGGAACGGTAGATTACATCGGCTTTTCATATTACATGTCCTTTGTCATTGATGCTCACCGTGAAAATAATCCTTACTATGATTATCTAGAAACAGAAGATTTAGTTAAAAATCCTTATGTAAAGGCTTCTGACTGGGATTGGCAAATAGATCCTCAAGGTTTGCGTTATGCTCTCAATTGGTTTACTGACATGTATCATTTACCGCTTTTCATTGTTGAGAATGGCTTTGGAGCCATTGATCAAGTTGAAGCTGATGGCATGGTTCACGACGATTATCGGATTGATTATCTGGGTGCTCATATCAAGGAGATGATTAAGGCTGTTGATGAAGATGGCGTTGAGCTCATGGGCTATACACCTTGGGGATGTATTGATCTGGTTTCAGCAGGAACAGGTGAAATGCGCAAGCGCTACGGTTTTATTTATGTTGATAAGGACGATGAAGGCAAGGGAACCCTCAAACGTTCACCAAAATTATCATTCAATTGGTATAAAGAAGTCATTGCTTCAAATGGAGATGACATTTAA","5.00","-20.19","55126","MSKLPENFLWGGAVAAHQLEGGWQEGGKGISVADVMTAGRHGVAREITAGVLEGKYYPNHEAIDFYHHYKEDVKLFAEMGFKCFRTSIAWTRIFPKGDEAEPNEAGLQFYDDLFDECLKYGIEPVVTLSHFELPYHLVTEYGGFTNRKVIDFFVHFAEVCFRRYKDKVKYWMTFNEINNQANYQEDFAPFTNSGIVYKEGDDREAIMYQAAHYELVASARAVKIGHAINPNLNIGCMVAMCPIYPATCNPKDILMAQKAMQKRYYFADVHVHGFYPEHIFKYWERKAIKVDFTERDKKDLFEGTVDYIGFSYYMSFVIDAHRENNPYYDYLETEDLVKNPYVKASDWDWQIDPQGLRYALNWFTDMYHLPLFIVENGFGAIDQVEADGMVHDDYRIDYLGAHIKEMIKAVDEDGVELMGYTPWGCIDLVSAGTGEMRKRYGFIYVDKDDEGKGTLKRSPKLSFNWYKEVIASNGDDI","1531446","For other 'bgl' genes see SMu0700 (bglB); SMu0890 (bglP); SMu0891 (bglB); SMu0892 (bglB); SMu0893 (bglC); SMu0895 (bglA); SMu1007 (bglC); SMu1285 (bglC) and SMu1454 (bglG).","6-phospho-beta-glucosidase, required for cellobiose uptake and metabolism","Cytoplasm, Extracellular","Matches in gapped BLAST to beta-glucoside:residues 5-474 are 51% similar to the previously published protein in S.mutans (gi:9622923).Residues 1-469 are 34% similar to phospho-beta-galactosidase in S.mutans (gi:433810). Residues 1-477 are 86% similar to the enzyme from S.pyogenes(gi:15902320).Residues 4-477 are 72% similar to 6-phospho-beta-glucosidase from Lactococcus lactis (gi:15672399).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1103 (1e-145).","

InterPro
IPR001360
Family

Glycoside hydrolase, family 1
PR00131	$\"[304-318]T$ $\"[371-379]T$ $\"[392-403]T$ $\"[414-431]T$ $\"[439-451]T$	GLHYDRLASE1
PTHR10353	$\"[1-476]T$	Glyco_hydro_1
PF00232	$\"[1-475]T$	Glyco_hydro_1
PS00572	$\"[371-379]T$	GLYCOSYL_HYDROL_F1_1
PS00653	$\"[8-22]T$	GLYCOSYL_HYDROL_F1_2

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[3-470]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
PTHR10353:SF3	$\"[1-476]T$	PTHR10353:SF3
SSF51445	$\"[1-474]T$	SSF51445

","No hits to the COGs database.","***** IPB001360 (Glycoside hydrolase family 1) with a combined E-value of 1.1e-54. IPB001360A 4-22 IPB001360B 64-97 IPB001360C 265-276 IPB001360D 306-315 IPB001360E 413-440","Residues 84-177 are 24% similar to a (HYDROLASE LACTASE ZYMOGEN PRECURSOR) protein domain (PD018129) which is seen in LPH_RAT.Residues 109-176 are 52% similar to a (BGLB PHOSPHO-BETA-GLUCOSIDASE) protein domain (PD350257) which is seen in Q9X564_ENTFC.Residues 175-297 are 29% similar to a (BGLB PHOSPHO-BETA-GLUCOSIDASE) protein domain (PD295003) which is seen in Q9X564_ENTFC.Residues 62-97 are 88% similar to a (BETA-GLUCOSIDASE HYDROLASE AMYGDALASE) protein domain (PD235643) which is seen in O50658_BBBBB.Residues 5-60 are 43% similar to a (II PHOSPHO-BETA-GALACTOSIDASE) protein domain (PD246278) which is seen in O50658_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Feb 27 11:14:08 2006","Mon Feb 27 11:14:08 2006","Mon Feb 27 11:14:08 2006","Thu Mar 14 15:47:38 2002","Thu Mar 14 15:47:38 2002","Thu Mar 14 15:47:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1456 is paralogously related (blast p-value < 1e-3) to SMu1007, SMu0895, and SMu1355, all predicted phospho-beta-glucosidases.","Tue Apr 2 14:08:30 2002","Mon Feb 27 11:14:08 2006","pdb1QOXA Chain A, Beta-Glucosidase From Bacillus Circulans Sp... 220 3e-058pdb1TR1A Chain A, Crystal Structure Of E96k Mutated Beta-Gluc... 217 2e-057pdb1BGGA Chain A, Glucosidase A From Bacillus Polymyxa Comple... 217 2e-057","SMU.1601c","","Residues 1 to 475 (E-value = 1.3e-137) place SMu1456 in the Glyco_hydro_1 family which is described as Glycosyl hydrolase family 1 (PF00232)","Thu Mar 14 15:47:38 2002","","","Old LA, Lowes S, Russell RR.Genomic variation in Streptococcus mutans: deletions affecting the multiple pathways of beta-glucoside metabolism.Oral Microbiol Immunol. 2006 Feb;21(1):21-7.PMID: 16390337Cote CK, Honeyman AL.The transcriptional regulation of the Streptococcus mutans bgl regulon.Oral Microbiol Immunol. 2002 Feb;17(1):1-8.PMID: 11860549Cote CK, Cvitkovitch D, Bleiweis AS, Honeyman AL.A novel beta-glucoside-specific PTS locus from Streptococcus mutans that is not inhibited by glucose.Microbiology. 2000 Jul;146 ( Pt 7):1555-63.PMID: 10878120Rosey EL, Stewart GC.Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans.J Bacteriol. 1992 Oct;174(19):6159-70.PMID: 1400164Honeyman AL, Curtiss R.Isolation, characterization and nucleotide sequence of the Streptococcus mutans lactose-specific enzyme II (lacE) gene of the PTS and the phospho-beta-galactosidase (lacG) gene.J Gen Microbiol. 1993 Nov;139(11):2685-94.PMID: 8277252","Brown,G.D. and Thomson,J.A. Isolation and characterisation of an aryl-beta-D-glucoside uptake and utilisation system (abg) from the gram-positive ruminal Clostridium species C. longisporum Mol. Gen. Genet. 257 (2), 213-218 (1998) PubMed: 9491080 Le Coq,D., Lindner,C., Kruger,S., Steinmetz,M. and Stulke,J. New beta-glucoside (bgl) genes in Bacillus subtilis: the bglP gene product has both transport and regulatory functions similar to those of BglF, its Escherichia coli homolog J. Bacteriol. 177 (6), 1527-1535 (1995) PubMed: 7883710 ","Mon Feb 27 11:14:08 2006","Thu Mar 14 15:49:35 2002","1","","","SMU.1601c","" "SMu1457","1533196","1533861","666","ATGACTAAAGAAGATATTAAAAAACAAGTCCGTCAGGCTTTTGATCATCGTGTTGCCGTACGTGTTTATAATGATCAAAAAATTCCCAAAGAAGACATGGATTTTATTCTTGACTGTGCTTGGCTCAGTCCTTCTTCTATCGGACTTGAACCTTGGCGTTTTATCGTTTTGGAAAATGAAGCGGTCAAAAAGCAGCTCAAAGAAATTGCCTGGGGAGCTCAATATCAGCTAGAAACTGCTAGCCATTTTGTGCTCGCCATTGCTAGAAAGGATGTTCGCTACGATTCTGAAAATATTCGTCAGAGTTTAATCCGTCGCGGTTTAAAGGACAAAGAAACCTTGGAAGCCCGCCTCAAACTCTATCAAACTTTCCAAGAAAACGATTTGGCGCTAACCAATGAACGTTCCCTTTTTGATTGGGCAGCCAAGCAAACTTACATTGCCATGGGCAATATGATGACTGCTGCCAGCATGATTGGCATTGATTCTTGCCCAATTGAAGGCTTTCATTATGCTAAAGCCAATCAGATCTTAGCTCAGGCAGGGCTCATTGATCCTGAAAAAGAAGGAATCGCTAATATGATTTCTTTTGGTTATCGCTTGCGTGATCCCAAACATCCTCGCAGCCGCAAACCGCGCCAAGAAGTTATCTTCTGGTCAGATTAA","8.60","2.88","25625","MTKEDIKKQVRQAFDHRVAVRVYNDQKIPKEDMDFILDCAWLSPSSIGLEPWRFIVLENEAVKKQLKEIAWGAQYQLETASHFVLAIARKDVRYDSENIRQSLIRRGLKDKETLEARLKLYQTFQENDLALTNERSLFDWAAKQTYIAMGNMMTAASMIGIDSCPIEGFHYAKANQILAQAGLIDPEKEGIANMISFGYRLRDPKHPRSRKPRQEVIFWSD","1533871","","NAD(P)H-flavin oxidoreductase","Cytoplasm","Matches in gapped BLAST to NAD(P)H-flavin oxidoreductase: residues 4-217 are 61% similar to the enzyme in S.pyogenes (gi15674616) and residues 5-219 are 46% similar to the protein from B.subtilis (gi16077850). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1477 (3e-86).","

InterPro
IPR000415
Family

Nitroreductase
PF00881	$\"[14-199]T$	Nitroreductase

noIPR
unintegrated

unintegrated
G3DSA:3.40.109.10	$\"[8-217]T$	G3DSA:3.40.109.10
PIRSF000232	$\"[8-220]T$	NADHdh_nitroRD
PTHR23026	$\"[39-219]T$	PTHR23026
PTHR23026:SF43	$\"[39-219]T$	PTHR23026:SF43
SSF55469	$\"[7-220]T$	SSF55469

","BeTs to 8 clades of COG0778COG name: Nitroreductase family proteinsFunctional Class: CThe phylogenetic pattern of COG0778 is AmT--qVcEBRHUJ-------Number of proteins in this genome belonging to this COG is 3","***** IPB000415 (Nitroreductase family) with a combined E-value of 1.7e-15. IPB000415A 44-56 IPB000415B 151-169","Residues 133-219 are 59% similar to a (OXIDOREDUCTASE COMPLETE PROTEOME) protein domain (PD036524) which is seen in Q9CMS8_PASMU.Residues 135-170 are 72% similar to a (PROTEOME NADPH-FLAVIN COMPLETE) protein domain (PD405302) which is seen in Q9JV33_NEIMA.Residues 13-59 are 52% similar to a (PROTEOME COMPLETE OXIDOREDUCTASE NITROREDUCTASE RDXA) protein domain (PD001645) which is seen in Q9CK06_PASMU.Residues 64-131 are 41% similar to a (OXIDOREDUCTASE PROTEOME NADPH-FLAVIN) protein domain (PD009589) which is seen in O25359_HELPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 09:38:05 2002","Thu Mar 14 15:54:46 2002","Tue Apr 3 14:23:58 2007","Thu Mar 14 15:54:46 2002","Thu Mar 14 15:54:46 2002","Thu Mar 14 15:54:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1457 is paralogously related (blast p-value < 1e-3) to SMu1135, and SMu0312 both predicted nitroreductases.","Thu Mar 14 15:54:46 2002","Tue Apr 3 14:23:58 2007","pdb1NOX Nadh Oxidase From Thermus Thermophilus 74 2e-014pdb1VFRA Chain A, The Major Nad(P)h:fmn Oxidoreductase From V... 68 1e-012","SMU.1602","","Residues 14 to 199 (E-value = 5.2e-55) place SMu1457 in the Nitroreductase family which is described as Nitroreductase family (PF00881)","Thu Mar 14 15:54:46 2002","24379983","","","Jorgensen MA, Trend MA, Hazell SL, Mendz GL.Potential involvement of several nitroreductases in metronidazole resistance in Helicobacter pylori.Arch Biochem Biophys. 2001 Aug 15;392(2):180-91.PMID: 11488591","","Mon Mar 18 09:38:05 2002","1","","","SMU.1602","" "SMu1458","1533897","1534289","393","ATGAAATTTTTACATACCTGTATCCGTGTTAAGGACTTAGACGCTTCGCTTAAATTTTATCAAGAGGCACTAGACTTCAAAGAAGTTCGCCGCAATGATTTTCCTGAATACAAATTTACTCTGGTTTATCTGCAACTAGAAGACGACCCCGACTATGAGTTAGAATTAACTTACAATTACGATCACGAAGCTTATGACCTTGGCAATGGCTATGGTCATATCGCTGTCGGTGTTGATGACCTTGAAGCGACTCATCAAGCGCATCAAAAAGCCGGCTATACTGTGACAGACCTTTCAGGTCTGCCCGGTAAGCCAAAGATGTACTACTTCATCACAGACCCCGATGGCTATAAGATCGAAGTTATCCGTCTCAAACAATTTCAGGAAAAATAA","4.80","-7.85","15255","MKFLHTCIRVKDLDASLKFYQEALDFKEVRRNDFPEYKFTLVYLQLEDDPDYELELTYNYDHEAYDLGNGYGHIAVGVDDLEATHQAHQKAGYTVTDLSGLPGKPKMYYFITDPDGYKIEVIRLKQFQEK","1534299","From Genbank:[gi:1175222]This enzyme catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.","lactoylglutathione lyase","Cytoplasm","Limited matches in gapped BLAST to lactoylglutathione lyase: residues 2-125 are 61% similar to the enzyme in S.pneumoniae (gi15902908). Residues 1-124 are 64% similar to the protein from S.pyogenes (gi15674615).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1478 (5e-63).","

InterPro
IPR004360
Domain

Glyoxalase/bleomycin resistance protein/dioxygenase
PF00903	$\"[2-121]T$	Glyoxalase

InterPro
IPR004361
Family

Glyoxalase I
TIGR00068	$\"[3-129]T$	glyox_I
PS00935	$\"[68-80]T$	GLYOXALASE_I_2

InterPro
IPR011588
Domain

Glyoxalase/extradiol ring-cleavage dioxygenase
PD002334	$\"[4-121]T$	Gly_diox

noIPR
unintegrated

unintegrated
G3DSA:3.10.180.10	$\"[2-122]T$	G3DSA:3.10.180.10
PTHR10374	$\"[1-122]T$	PTHR10374
SSF54593	$\"[1-121]T$	SSF54593

","BeTs to 7 clades of COG0346COG name: Lactoylglutathione lyaseFunctional Class: EThe phylogenetic pattern of COG0346 is A-tky--CEBRh---------Number of proteins in this genome belonging to this COG is 2","***** IPB000325 (Glyoxalase I) with a combined E-value of 9.2e-36. IPB000325A 5-43 IPB000325B 54-63 IPB000325C 69-103 IPB000325D 108-120 IPB000325C 1-35","Residues 9-122 are 48% similar to a (LYASE I GLYOXALASE LACTOYLGLUTATHIONE) protein domain (PD002334) which is seen in LGUL_HAEIN.Residues 5-120 are 32% similar to a (RESISTANCE PROTEOME FOSFOMYCIN COMPLETE) protein domain (PD016133) which is seen in Q9KBZ6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 09:32:42 2002","Thu Mar 14 16:01:08 2002","Tue Aug 1 10:42:55 2006","Thu Mar 14 16:01:08 2002","Thu Mar 14 16:01:08 2002","Thu Mar 14 16:01:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1458 is paralogously related (blast p-value < 1e-3) to SMu1015, a predicted conserved hypothetical protein.","Thu Mar 14 16:01:08 2002","Tue Aug 1 10:42:55 2006","pdb1F9ZA Chain A, Crystal Structure Of The Ni(Ii)-Bound Glyox... 97 9e-022pdb1QIPB Chain B, Human Glyoxalase I Complexed With S-P- Nitr... 66 2e-012pdb1BH5B Chain B, Human Glyoxalase I Q33e, E172q Double Mutan... 65 4e-012","SMU.1603","","Residues 2 to 121 (E-value = 1.2e-27) place SMu1458 in the Glyoxalase family which is described as Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily (PF00903)","Thu Mar 14 16:01:08 2002","24379984","","","Kizil,G., Wilks,K., Wells,D. and Ala'Aldeen,D.A.Detection and characterisation of the genes encoding glyoxalase Iand II from Neisseria meningitidisJ. Med. Microbiol. 49 (7), 669-673 (2000)PubMed: 10882093","","Tue Aug 1 10:42:55 2006","1","","","SMU.1603","700" "SMu1459","1535135","1534623","513","ATGCAAGGTAAAGATATTATTTTAGGGATATTGAGCAAGAAAGAACGTTCGGGTTATGAAATCAATGATATACTGCAAAATCAGTTATCTTATTTTTATGATGGCACCTATGGTATGATCTATCCTACTTTAAGAAAACTTGAAAAAGATGGGAAAATTACAAAAGAAGTTGTTATTCAAGATGGTAGGCCAAATAAAAATATCTATGCGATCACAGAATCTGGCAAGAAGGAATTGGCTTCTTATTTACAGTCAGATGTAAATGATGAAATTTTCAAGTCTGATTTTCTCATGAGATTATTTTTTGGAAATTCTTTAAACGATGATGATTTAGAACAATTGATAAGAGAAGAAATTGAGAGAAAGGAAGAAAAAATTAAACGTTTAAGTGAGAATCTTGAAATTTGGAAAAAGAAGGGAGAATTAACTCCAACTCAGGAAATTACTATCAAATATGGTTTAGCTCAATATAAGTCTACTAAAAAAGTCTTAGAAGAAGAATTGGCAAAATGA","5.30","-1.99","19839","MQGKDIILGILSKKERSGYEINDILQNQLSYFYDGTYGMIYPTLRKLEKDGKITKEVVIQDGRPNKNIYAITESGKKELASYLQSDVNDEIFKSDFLMRLFFGNSLNDDDLEQLIREEIERKEEKIKRLSENLEIWKKKGELTPTQEITIKYGLAQYKSTKKVLEEELAK","1534639","","conserved hypothetical protein","Cytoplasm","Few matches in gapped BLAST to conserved hypotheticals: residues 7-103 are 35% similar to gi|15616514| from B.halodurans and gi|7475008| from B.subtilisSMu1459 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005149
Family

Transcriptional regulator PadR-like
PF03551	$\"[6-82]T$	PadR

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-89]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[6-85]T$	SSF46785

","BeTs to 7 clades of COG1695COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1695 is A-Tk--V-ebR----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 7-79 are 30% similar to a (COMPLETE PROTEOME RIBOSOMAL) protein domain (PD230683) which is seen in Q9EXE6_LACPL.Residues 4-83 are 41% similar to a (PROTEOME COMPLETE YUCF YFIO) protein domain (PD403060) which is seen in P94443_BACSU.Residues 7-83 are 38% similar to a (PROTEOME COMPLETE) protein domain (PD285468) which is seen in O50432_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:20:48 2002","Thu Mar 14 16:06:08 2002","Wed Oct 9 08:20:48 2002","Thu Mar 14 16:06:08 2002","","Thu Mar 14 16:06:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1459 is paralogously related (blast p-value < 1e-3) to SMu0146, a predicted hypothetical and SMu1552, a predicted conserved hypothetical.","Thu Mar 14 16:06:08 2002","","No significant hits to the NCBI PDB database.","SMU.1604c","","Residues 1 to 82 (E-value = 2.3e-12) place SMu1459 in the PadR family which is described as Transcriptional regulator PadR-like family (PF03551)","Thu Mar 14 16:06:08 2002","24379985","","","","","","1","","","SMU.1604c","" "SMu1460","1535259","1536944","1686","ATGAAACGTTTATTTGCTATTGTTGCTATGTGTGTCGGCATCTTCCTATGTATGCTGGACACGACCGTCATGAATATTGCCCTACCAGCTATTCAGGACAGTCTAAAAGTGAACCTTAATGATCTTCAATGGTCTTTAAATGTCTATACGATTATTTTTGCTTCCTTAACGATTCCTTTAAGTAAGTTGGCTGAAAAGTTTGGAAAACACAAATTTTATCTTCTAGGATTGCTTACTTTTATGGGAGGATCTCTGATTTCTGCACTGAGTTCTGATCTTAACTTTCTCATTTTTGGCCGCGGGATTCAAAGTATCGGAGCAGCTATTGTCTTTCCTTTATCCATGACAATTGGGATCAATACCGTCAGTCTTAATACGCGTAAAAGCGTCATAGCAGCTTTAGGCGTTACTCAAGGTCTGGCTGCTGCTTTAGGACCAACCATTGGAGGCGTCTTGACACAGTTCTTGGGCTGGCGTTGGATTTTCCTAATTAATCTGCCTTTGATGGTAATTTCCTTTATAATTTGCCTTGTATGTCTCGATTTACAAGAAAGAAAAGAAAAAGCCAAGATTGATTATCTTGGTGCTCTTATCAGTATGGCAACACTTTTTTCATTGACATTGGGCCTTGTTCAAGGACGAGATTGGGGCTGGACCAGCTTTAATATCCTCACCTTACTCATCAGTTCAGCCGTCTTGCTTATTCTCTTCATTCTCTGGGAAAAAGGCTGTCAAGATCCTATGGTTCCCTTAAATCTCTTTAAAAACAAAGAATTTATGGGTTCTGCTATCGCAATTATTCTCAGCAATGTCTTTTTGGTAGCTGTAACAGTTGTATTGCCTACCTATTTTACCCGTGTACAAAGTAAAACGGAATTGGAAGCTGCTTTATTAGTCACTCCAATTACAGCCATGATTCTTATTTTCTCTCCGCTTGCTGCTTTCATTATTGATAAATTGGGACCCCGTCTGGTCATTGCCAGCGGTTTCACCTTAATGGCAGCTGCCTATATTCTGTTTACAAAAATTGATATGGCTGACAGCACCCAGACAACTCTAACCTGCTTGATTCTGGGGACTGGTTACGGTATTATCGCTGGTCCTATTACCGTGTTAGCTGCCTCAAACTTCACTGGGAGTCTGTTAACGGCGTCCCAAAGTGTCGCTGGAGTTCTCAGGCAGGTAGGTATTGTCTTGGCTGTTGCCGTTTATGTCACAGGTCTTTATACAAACCTTGGCACTGCCAAAAAAGAAGCGATTAGCTATATTAAAACTGAGGTCAAAACCATTGATGTTTCAAAAGAAAAACAGCAAACGATTCAAAAAACAGCGATTCATTCTTTAGGACAAAGTACTAGTCATCAGACGGTTTCTAATCACTTCTCCAAAACCGAGCGCAAAGGAATCATTAATGAGGCTTATCAAAAGACTCTGCAGAAATACCCAAGCAAACTTCCTCAAGTACAAAAACAAGAAATTTACAAGAAAGTCAAAGCCAGTGTGGAGAAAAAACTAGCAACGATTAATAAACAGATTAACAAAGCGATCAAGCATATTAAAGATTATTCTAGGAAAAGATATACCAAAGCCTTCACCAAACTTTACAGTTACTCAATTATATTCATTATTTTAGCTATTTTTTCAAGCCTACTATTCCCCAGAAAAAATACAATTATATCAATGTAA","10.60","28.92","61508","MKRLFAIVAMCVGIFLCMLDTTVMNIALPAIQDSLKVNLNDLQWSLNVYTIIFASLTIPLSKLAEKFGKHKFYLLGLLTFMGGSLISALSSDLNFLIFGRGIQSIGAAIVFPLSMTIGINTVSLNTRKSVIAALGVTQGLAAALGPTIGGVLTQFLGWRWIFLINLPLMVISFIICLVCLDLQERKEKAKIDYLGALISMATLFSLTLGLVQGRDWGWTSFNILTLLISSAVLLILFILWEKGCQDPMVPLNLFKNKEFMGSAIAIILSNVFLVAVTVVLPTYFTRVQSKTELEAALLVTPITAMILIFSPLAAFIIDKLGPRLVIASGFTLMAAAYILFTKIDMADSTQTTLTCLILGTGYGIIAGPITVLAASNFTGSLLTASQSVAGVLRQVGIVLAVAVYVTGLYTNLGTAKKEAISYIKTEVKTIDVSKEKQQTIQKTAIHSLGQSTSHQTVSNHFSKTERKGIINEAYQKTLQKYPSKLPQVQKQEIYKKVKASVEKKLATINKQINKAIKHIKDYSRKRYTKAFTKLYSYSIIFIILAIFSSLLFPRKNTIISM","1536954","","MDR-type permease;transmembrane efflux protein","Membrane, Cytoplasm","Weak similarities to a previously published sequence in Genbank.Residues 1-318 are 28% similar to MepA in S.mutans(gi|15625447|)Several similarities in gapped BLAST to MDR-type permeases. Residues 3-532 are 29% similar to gi|15004812| from C.acetobutylicum. Residues 7-422 are 30% similar to gi|15843349| from M.tuberculosis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1707 (1e-34).","

InterPro
IPR001411
Family

Tetracycline resistance protein TetB
PR01036	$\"[9-33]T$ $\"[100-120]T$ $\"[130-154]T$ $\"[294-318]T$	TCRTETB

InterPro
IPR004638
Family

Drug resistance transporter EmrB/QacA subfamily
TIGR00711	$\"[4-482]T$	efflux_EmrB

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[6-437]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[10-410]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[2-195]T$ $\"[245-406]T$	PTHR10074
PTHR10074:SF57	$\"[2-195]T$ $\"[245-406]T$	PTHR10074:SF57
SSF103473	$\"[1-556]T$	SSF103473

","BeTs to 15 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 140-191 are 42% similar to a (TRANSMEMBRANE COMPLETE PROTEOME RESISTANCE TRANSPORT) protein domain (PD001095) which is seen in Q9CFW6_LACLA.Residues 190-404 are 21% similar to a (PROTEOME RELATED COMPLETE EMRA) protein domain (PD276003) which is seen in Q9HID6_THEAC.Residues 140-174 are 51% similar to a (TRANSMEMBRANE PROTEOME COMPLETE TRANSPORT) protein domain (PD343941) which is seen in O05884_MYCTU.Residues 187-337 are 24% similar to a (TRANSMEMBRANE PROTEOME COMPLETE TRANSPORT) protein domain (PD073393) which is seen in O53186_MYCTU.Residues 159-343 are 24% similar to a (PROTEOME MFS COMPLETE TRANSPORTER) protein domain (PD321074) which is seen in Q9I008_PSEAE.Residues 246-404 are 27% similar to a (PROTEOME COMPLETE TRANSMEMBRANE MULTIDRUG) protein domain (PD073406) which is seen in O31563_BACSU.Residues 7-80 are 32% similar to a (MEMBRANE EFFLUX INTEGRAL) protein domain (PD337053) which is seen in Q9ZBW5_STRCO.Residues 201-335 are 28% similar to a (MEMBRANE INNER TRANSPORT KDGR-HTPX) protein domain (PD331952) which is seen in YEBQ_ECOLI.Residues 192-259 are 38% similar to a (COMPLETE PROTEOME RESISTANCE EFFLUX) protein domain (PD416139) which is seen in O28026_ARCFU.Residues 194-413 are 20% similar to a (EFFLUX) protein domain (PD091825) which is seen in O31131_BRELN.Residues 226-338 are 32% similar to a (COMPLETE PROTEOME TRANSPORTER) protein domain (PD279163) which is seen in Q9CIW8_LACLA.Residues 189-250 are 38% similar to a (TRANSMEMBRANE RESISTANCE TRANSPORT) protein domain (PD348727) which is seen in Q9L0L9_STRCO.Residues 7-80 are 35% similar to a (TRANSMEMBRANE TRANSPORT TRANSPORTER COMPLETE PROTEOME) protein domain (PD000082) which is seen in O69695_MYCTU.Residues 189-265 are 37% similar to a (PROTEOME COMPLETE EFFLUX TRANSMEMBRANE) protein domain (PD389959) which is seen in Q9CEG6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 16:17:58 2002","Thu Mar 14 16:15:08 2002","Thu Oct 17 10:52:32 2002","Thu Mar 14 16:15:08 2002","","Thu Mar 14 16:15:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1460 is paralogously related (blast p-value < 1e-3) to SMu0119, SMu0677, SMu1914, SMu1173,and SMu1465, all permease-related proteins and SMu1287, a predicted conserved hypothetical protein. ","Thu Mar 14 16:17:58 2002","","No significant hits to the NCBI PDB database.","SMU.1605","","No significant hits to the Pfam 11.0 database","Thu Mar 14 16:15:08 2002","24379986","","","","","","1","","","SMU.1605","" "SMu1461","1537442","1536975","468","ATGGTAAAGGCTCAAGGAAACGTCGTCGCTCAAAATAAAAAAGCCAGACATGACTATGAGATTCTAGAAACTTATGAAGCAGGCATCGTGTTGACAGGAACTGAGATTAAGAGTGTTCGTGCGGCAAGAATTACTCTCAAAGATGGTTTTGCTCAGGTTAAAAATGGTGAGGTTTGGCTAAATAATGTCCATATTACACCTTATGAACAGGGTAATATCTGGAATCAGGATCCTGATCGTACCCGTAAGCTCCTCCTTAAAAAGAGAGAAATTGCAAAATTGGACAATGAACTCAAAGGGACAGGGATGACCTTAGTTCCTCTTAAGGTTTATCTCAAAAACGGCTTTGCTAAGGTTCTCATCGGGCTTGCCAAAGGGAAACATGATTACGACAAACGTGAATCCATAAAGCGCCGCGAACAAGATCGCGACATTAAACGGCAAATGAAGCAGTTTAATGGGAGATAA","10.80","13.72","17844","MVKAQGNVVAQNKKARHDYEILETYEAGIVLTGTEIKSVRAARITLKDGFAQVKNGEVWLNNVHITPYEQGNIWNQDPDRTRKLLLKKREIAKLDNELKGTGMTLVPLKVYLKNGFAKVLIGLAKGKHDYDKRESIKRREQDRDIKRQMKQFNGR","1536991","From Genbank:[gi:6686320]SsrA-binding protein binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes.","SsrA-binding protein (small protein B)","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical and to SsrA-binding protein:residues 1-155 are 80% similar to a conserved hypothetical gi15674609 from S.pyogenes and are 78% similar to SsrA-binding protein from S.pneumoniae gi15900853The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1481 (3e-76).","

InterPro
IPR000037
Family

SmpB protein
PD004488	$\"[9-132]T$	SmpB
PF01668	$\"[7-74]T$	SmpB
TIGR00086	$\"[8-150]T$	smpB
PS01317	$\"[27-39]T$	SSRP

noIPR
unintegrated

unintegrated
G3DSA:2.40.280.10	$\"[1-128]T$	G3DSA:2.40.280.10
SSF74982	$\"[1-132]T$	SSF74982

","BeTs to 12 clades of COG0691COG name: tmRNA-binding protein SmpBFunctional Class: OThe phylogenetic pattern of COG0691 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000037 (SmpB protein) with a combined E-value of 1e-75. IPB000037A 9-50 IPB000037B 75-112 IPB000037C 118-150","Residues 8-74 are 86% similar to a (RNA-BINDING SSRA-BINDING PROTEOME) protein domain (PD004488) which is seen in O85201_STRPN.Residues 75-152 are 70% similar to a (RNA-BINDING SSRA-BINDING PROTEOME) protein domain (PD004792) which is seen in SSRP_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 09:23:33 2002","Tue Aug 1 12:07:55 2006","Tue Aug 1 12:07:55 2006","Thu Mar 14 16:24:09 2002","Thu Mar 14 16:24:09 2002","Thu Mar 14 16:24:09 2002","yes","Thu Oct 17 10:51:55 2002","SMu1461 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 16:25:10 2002","","No significant hits to the NCBI PDB database.","SMU.1606c","","Residues 7 to 74 (E-value = 1.1e-41) place SMu1461 in the SmpB family which is described as SmpB protein (PF01668)","Thu Mar 14 16:24:09 2002","","","","Roche ED, Sauer RT.Identification of endogenous SsrA-tagged proteins reveals tagging at positions corresponding to stop codons.J Biol Chem. 2001 Jul 27;276(30):28509-15. PMID: 11373298 ","","Mon Mar 18 09:23:33 2002","1","","","SMU.1606c","701" "SMu1462","1539741","1537405","2337","ATGAAAGAAAAAATTATTACTTATTTAGAAGAGAAGGGAAAATCAAGTGTTGATGATTTAGCCAGCAGTTTAGATATGGCTGGTGCTCAAAAATTTCCTTCTCTTATCAAGGAGATTTCCAAGCTCGAAAGTAAGGGTAAATTGCGCTTTGAGCAAGATGGCACAATCTCACTTAGAAAGAAGAAAGAAAAGAAAGACCAAGTTACTGTTACAGGTATTTTTCGTGCTAATAAGGCCGGTTTTGGCTTTGTCAGTATCGACGAAGCAGAAGAAGATCTTTTTATCGGCCGTAATGATGTTGGTCATGCAGTTGATGGTGATACGGTAGAGGTAGCGATTAAAAAAGTTGCTAATCGCCTTAAAGGAACGGCAGCAGAGGCGCGTGTTGTTAAGATTGTTGAGCACAGTTTAAAAGCAGTTGTCGGCCGTTTTGTTTTGGATGATGAAAAGCCTCCTTATATTGGCTATATTAAGAGTAAAAATCAAAAAATTACACAAAAGATTTATATTAAAAAAGAACCCATTGTTTTAGATGGGACTGAGATTATTAAGGTAGCAATTGAAAAGTATCCAACGCGGCGTTATGATTATTTTGTGGCCAGCGTTGAGGATGTGATTGGTCATCAGGACGATGTCGGAATAGATGTCTTGGAAGTTTTGGAATCCATGGATATCGTGTCTGAATTTCCTGACGCTGTTTTAAAAGAAGCCCAGTCCGTTCCGGATGCTCCCAGTGAGAAAGATTTGATCGGTCGAGTAGATTTACGCAAAGAGATTACTTTTACCATTGATGGGGCGGATGCTAAAGATTTGGATGATGCGGTTCATGTCAAATTATTAGATAATGGCAATTTTGAACTCGGTGTTCATATTGCCGATGTTTCTTATTATGTTAAGGAAGGCTCAGCTTTGGATGGTGAAGCCCTAGCTAGAGGAACCAGTGTGTATGTGACTGACCGTGTGGTTCCTATGCTACCTGAACGTTTGTCTAATGGTATTTGTTCCCTCAATCCTAATCTTGACCGTCTGACGCAGTCTGCTATTATGGAAATTGATAAGCACGGTCGTGTGCTCCATTATCAGATTACTCAAACTGTTATCAATACTAGTTTTCGTATGACTTACAGTGATGTCAATGCTATTATTGCAGGGGACAAAGAATTGACAGAGCAATACGATAAGATTGTACCGTCTATTCACTATATGGTGACCTTGCACAAGATTTTAGAAAAAATGCGTGAGAGACGTGGAGCCCTTAATTTTGATACCTCAGAAGCTAAAATTTTGGTTAATGATAAAGGCTTTCCTATGGACATCGTGCTACGCCAGCGTGGTTTAGCTGAGCGAATGATTGAGTCTTTCATGCTGGCAGCTAATGAATGCGTGGCTGAGCATTTTGCTAAGAAAAATCTTCCTTTTATCTACCGAATCCATGAAGAACCTAAGGCTGAAAAGTTACAGAAATTTATGGACTATGCGAGCATTTTTGGTGTCAGTATTCAGGGAACAGCCAGCAAAATCAGTCAGACAGCTCTGCAAGATTTTATGAAAAAAATTGAAGGGCAGCCGGGCAGTGATGTTCTTTCCATGATGTTACTGCGTTCCATGCAGCAGGCGCGTTATTCTGAGTATAATCATGGTCATTATGGTTTGGCAGCACAATACTATACGCATTTTACCAGTCCAATCCGCCGTTACCCAGACCTTTTGGTGCATCGCTTGGTGCGTGAATACGATAAAGCGAATTCTGAGAAAGTGGAGCATTTTGCACAAATTATTCCTGAAATTGCGAGTCAAACCAGCAGTTTGGAACGTCGTGCCATTGATGCTGAGCGTGTTGTTGAGGCCATGAAAAAAGCAGAATATATGGAAGAATATGTGGGGCAAGAATTCACTGGTGTTGTCTCCAGTGTTGTCAAATTCGGTCTTTTTGTAGAGCTGCCTAATACCATTGAAGGTCTCATTCATATGACGACCCTACCAGAATTTTATCAGTTTAATGAACGCACTTTAAGTTTGCAAGGTGAGAAATCCGGCAAGGTTTTCCGAGTTGGTCAATCCATCAAAGTAAAAGTGCTTAAGGCAGATAAGGAAACAGGGGATATTGATTTTGCCTATCTTCCAAGTGATTTTGATATCATTGAAAAGCTCTCTCGATCGAAAAAAGAGAAGCCGCGTCCTTCACGTCGCAGTGGCGACAGCAAAACGAAGGCTAATAAGCGTAGCAAACGATCAGCTCTTTCACAAAAGAAGAAAAAGAAGCCTTTTTATAAGGAGGCAGTAAAGAAGGGAGGCAAGCATGGTAAAGGCTCAAGGAAACGTCGTCGCTCAAAATAA","9.70","15.34","87846","MKEKIITYLEEKGKSSVDDLASSLDMAGAQKFPSLIKEISKLESKGKLRFEQDGTISLRKKKEKKDQVTVTGIFRANKAGFGFVSIDEAEEDLFIGRNDVGHAVDGDTVEVAIKKVANRLKGTAAEARVVKIVEHSLKAVVGRFVLDDEKPPYIGYIKSKNQKITQKIYIKKEPIVLDGTEIIKVAIEKYPTRRYDYFVASVEDVIGHQDDVGIDVLEVLESMDIVSEFPDAVLKEAQSVPDAPSEKDLIGRVDLRKEITFTIDGADAKDLDDAVHVKLLDNGNFELGVHIADVSYYVKEGSALDGEALARGTSVYVTDRVVPMLPERLSNGICSLNPNLDRLTQSAIMEIDKHGRVLHYQITQTVINTSFRMTYSDVNAIIAGDKELTEQYDKIVPSIHYMVTLHKILEKMRERRGALNFDTSEAKILVNDKGFPMDIVLRQRGLAERMIESFMLAANECVAEHFAKKNLPFIYRIHEEPKAEKLQKFMDYASIFGVSIQGTASKISQTALQDFMKKIEGQPGSDVLSMMLLRSMQQARYSEYNHGHYGLAAQYYTHFTSPIRRYPDLLVHRLVREYDKANSEKVEHFAQIIPEIASQTSSLERRAIDAERVVEAMKKAEYMEEYVGQEFTGVVSSVVKFGLFVELPNTIEGLIHMTTLPEFYQFNERTLSLQGEKSGKVFRVGQSIKVKVLKADKETGDIDFAYLPSDFDIIEKLSRSKKEKPRPSRRSGDSKTKANKRSKRSALSQKKKKKPFYKEAVKKGGKHGKGSRKRRRSK","1537421","From Genbank:[gi:7674332]This enzyme participates in an essential cell function.It acts nonspecifically on poly(A),poly (U) and ribosomal RNAs.","exoribonuclease R","Cytoplasm","Several matches in gapped BLAST to exoribonuclease R: residues 1-714 are 75% similar to the protein in S.pyogenes (gi15674608) and are 71% similar to the protein from S.pneumoniae (gi15458483). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1482 (0.0).","

InterPro
IPR001900
Domain

Ribonuclease II and R
PF00773	$\"[252-581]T$	RNB
PS01175	$\"[548-572]T$	RIBONUCLEASE_II

InterPro
IPR003029
Domain

RNA binding S1
PF00575	$\"[624-707]T$	S1
SM00316	$\"[626-707]T$	S1
PS50126	$\"[628-707]T$	S1

InterPro
IPR004476
Family

RNase II and RNase R, bacteria
TIGR00358	$\"[54-707]T$	3_prime_RNase

InterPro
IPR011805
Family

Ribonuclease R, bacterial
TIGR02063	$\"[1-708]T$	RNase_R

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[628-733]T$	OB_NA_bd_sub

InterPro
IPR013223
Domain

Ribonuclease B, OB region N-terminal
PF08206	$\"[72-129]T$	OB_RNB

noIPR
unintegrated

unintegrated
PTHR23355	$\"[50-759]T$	PTHR23355
PTHR23355:SF9	$\"[50-759]T$	PTHR23355:SF9
SSF46785	$\"[3-58]T$	SSF46785
SSF50249	$\"[67-130]T$ $\"[625-704]T$	Nucleic_acid_OB

","BeTs to 10 clades of COG0557COG name: ExoribonucleasesFunctional Class: KThe phylogenetic pattern of COG0557 is ----YqvCEb-Hujgp-lin-Number of proteins in this genome belonging to this COG is 1","***** IPB001900 (Ribonuclease II domain) with a combined E-value of 5e-52. IPB001900A 262-274 IPB001900B 287-326 IPB001900C 450-459 IPB001900D 556-575","Residues 633-703 are 54% similar to a (RIBOSOMAL COMPLETE PROTEOME RNA-BINDING 30S REPEAT) protein domain (PD000709) which is seen in Q9CH00_LACLA.Residues 72-216 are 23% similar to a (RIBONUCLEASE VACB PROTEOME COMPLETE) protein domain (PD220661) which is seen in Q9RED8_BURSP.Residues 204-606 are 66% similar to a (RIBONUCLEASE HYDROLASE COMPLETE PROTEOME EXONUCLEASE) protein domain (PD003098) which is seen in Q9CH00_LACLA.Residues 579-631 are 52% similar to a (RIBONUCLEASE PROTEOME EXONUCLEASE) protein domain (PD347722) which is seen in RNR_BACSU.Residues 447-575 are 32% similar to a (II EXORIBONUCLEASE HYDROLASE RNASE) protein domain (PD316878) which is seen in O14040_SCHPO.Residues 72-220 are 26% similar to a (HYDROLASE RNASE EXONUCLEASE HOMOLOG) protein domain (PD042372) which is seen in Q9PR88_UREPA.Residues 632-704 are 41% similar to a (PROTEOME COMPLETE RIBONUCLEASE) protein domain (PD391411) which is seen in Q9CG96_LACLA.Residues 56-195 are 45% similar to a (COMPLETE PROTEOME RIBONUCLEASE RNASE) protein domain (PD403247) which is seen in Q9CH00_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 09:19:12 2002","Thu Mar 14 16:28:44 2002","Thu Aug 10 11:07:02 2006","Thu Mar 14 16:28:44 2002","Thu Mar 14 16:28:44 2002","Thu Mar 14 16:28:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1462 is paralogously related (blast p-value < 1e-3) to SMu1097, a predicted ribosomal protein S1.","Thu Mar 14 16:29:04 2002","","No significant hits to the NCBI PDB database.","SMU.1607c","","Residues 173 to 543 (E-value = 1.3e-113) place SMu1462 in the RNB family which is described as RNB-like protein (PF00773)Residues 624 to 707 (E-value = 3.7e-15) place SMu1462 in the S1 family which is described as S1 RNA binding domain (PF00575)","Thu Aug 10 11:07:02 2006","","","","","","","1","","","SMU.1607c","158" "SMu1463","1540324","1540088","237","ATGTACAACTTTTTAGTAACAGCATTGCTAGTGTTATCCTTTATCTTGGTAATTGCTATTTTTATGCAGCCTCAAAAGAATCCTAGCAGCAATGTTTTTGATAATAGTGGATCAGAAGCTTTATTTGAGCGTACAAAGACTCGAGGTTTTGAAGCTTTTATGCAGCGTTTTACAGCCATTTTAGTCTTCTTTTGGCTTGCGATTGCCTTGGCAATTGTTGTTTTATCAAGTAAATAA","10.30","1.98","8807","MYNFLVTALLVLSFILVIAIFMQPQKNPSSNVFDNSGSEALFERTKTRGFEAFMQRFTAILVFFWLAIALAIVVLSSK","1540104","For other 'sec' genes see SMu1822 (secY) and SMu1674 (secA).From Genbank:[gi:6226126]This protein is involved in protein export.It participates in a early event of protein translocation.","preprotein translocase, SecG subunit","Membrane, Cytoplasm","Matches in gapped BLAST to hypothetical and to preprotein translocase, SecG subunit:residues 1-78 are 83% similar to gi15674607 from S.pyogenes and are 73% similar to gi15900851 from S.pneumoniaeThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1483 (1e-30).","

InterPro
IPR004692
Family

Preprotein translocase SecG subunit
PF03840	$\"[2-77]T$	SecG
TIGR00810	$\"[2-76]T$	secG

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-78 are 48% similar to a (PROTEOME SECG PROTEIN-EXPORT COMPLETE) protein domain (PD391214) which is seen in Q9CH01_LACLA.Residues 1-74 are 34% similar to a (TRANSLOCATION MEMBRANE PROTEIN-EXPORT) protein domain (PD406895) which is seen in SECG_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 09:23:00 2006","Tue Sep 19 09:23:00 2006","Tue Sep 19 09:23:00 2006","Thu Mar 14 16:33:54 2002","","Thu Mar 14 16:33:54 2002","yes","Tue Oct 15 10:29:40 2002","SMu1463 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 16:34:21 2002","","No significant hits to the NCBI PDB database.","SMU.1609c","","Residues 2 to 77 (E-value = 2.3e-24) place SMu1463 in the SecG family which is described as Preprotein translocase SecG subunit (PF03840)","Thu Mar 14 16:33:54 2002","24379989","","","","","","1","","","SMU.1609c","953" "SMu1464","1540519","1540373","147","GTGCGTATCAAGATTAATCTGCAATGTTCACATTGTGGCAGTAAAAATTATTTGACTAGTAAAAATAAGAAAAATCATCCAGAAAAAATTCAGGTTCCTAAATATTGTCCTAAGGAAAGAAAGGTGACCTTGCATATTGAATCCTAA","10.60","8.55","5602","MRIKINLQCSHCGSKNYLTSKNKKNHPEKIQVPKYCPKERKVTLHIES","1540389","For other 'rpm' genes see SMu0638 (rpmI);SMu0108 (rpmB);SMu0773 (rpmA); SMu0306 (rpmH) and SMu1185 (rpmE). ","50S ribosomal protein L33","Extracellular, Periplasm, Cytoplasm","Several matches in gapped BLAST to 50S ribosomal protein L33: residues 1-48 are 77% similar to the protein in S.pneumoniae (gi|15900850|) and are 56% similar to the protein from B.stearothermophilus(gi|132893|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1484 (2e-22).","

InterPro
IPR001705
Family

Ribosomal protein L33
PD002595	$\"[1-47]T$	Q8DSZ3_STRMU_Q8DSZ3;
PF00471	$\"[2-47]T$	Ribosomal_L33
TIGR01023	$\"[1-47]T$	rpmG_bact: ribosomal protein L33
PS00582	$\"[17-36]T$	RIBOSOMAL_L33

","BeTs to 10 clades of COG0267COG name: Ribosomal protein L33Functional Class: JThe phylogenetic pattern of COG0267 is ----yqvceBrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001705 (Ribosomal protein L33) with a combined E-value of 5e-13. IPB001705 17-48","Residues 2-48 are 57% similar to a (RIBOSOMAL 50S CHLOROPLAST TYPE COMPLETE CYANELLE) protein domain (PD002595) which is seen in R331_BACST.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 10:50:05 2002","Thu Mar 14 16:43:08 2002","Thu Oct 17 10:50:05 2002","Thu Mar 14 16:36:56 2002","Thu Mar 14 16:36:56 2002","Thu Mar 14 16:36:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1464 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 16:43:08 2002","","No significant hits to the NCBI PDB database.","SMU.1610c","","Residues 2 to 48 (E-value = 3.6e-17) place SMu1464 in the Ribosomal_L33 family which is described as Ribosomal protein L33 (PF00471)","Thu Mar 14 16:36:56 2002","","","","Kruft,V., Kapp,U. and Wittmann-Liebold,B.Characterization and primary structure of proteins L28, L33 and L34 from Bacillus stearothermophilus ribosomesBiochimie 73 (7-8), 855-860 (1991)PubMed: 1742360","","Thu Mar 14 16:44:01 2002","1","","","SMU.1610c","954" "SMu1465","1541688","1540519","1170","TTGATAGCTTGGTTCGGTAGCTTTTTTACTGGAGCAAGCTTTTCACTTGTCATGCCTTTTATGGCTTTATTTGTTGAGGAATTAGGCGTAAAAGGTGACTTGGTCAAGCTTTATGCAGGCCTTGCAGTGTCAATTTCAGCCTTAGCTTCTGCTCTTTTTGCACCTGTTTGGGGACGTTTGGCAGACCGTTATGGACGCAAGCCCATGATGATTCGAGCTAGTCTTGTCATGACTTTTACCATGGGCGGTCTAGCTTTTGTGACGGATGTCTATGGGCTGCTTTTTTTACGTTTGCTTAATGGGATGTTTGCGGGTTATGTGCCAAATGCCAATGCACTTATTGCTTCTCAGGCTCCTAAAAATGAATCAGGTTCTGCTCTTGGAACTTTGGCTACTGGTGTTATTGCTGGCAGTCTAATTGGTCCTCTTATGGGCGGTATGCTTGCTGAATTTTTAGGTATTCGCAATGTCTTTCTCTTGGTTGGCACTTTGCTTTTATTGGTAATGCTGCTGACAACTTTTTTTATTCAGGAAGATTTCCGACCTGTATCTAAGAAAGATATCTTATCTACTAAAGAACTCTTTGCTCAAATTAAAGATCGGCAAATACTATTGGGGCTTTTTGTTACCAGTATGATTATTCAAATTTCAGCTCAGTCTGTTGCCCCTATTCTGGCACTTTATATTAGATATCTAGGGCAAAGGGACAATCTGATGTTAATTGCGGGCTTAATTGTGTCTGCTATGGGCTTTTCCAGCATTATTTCCAGTTCAAGATTTGGGAAATTAGGTGATAAAATTGGCAATCACCGTATGTTATTAGCAGGTCTTTTTTATTGTGGTATTATTTATTTGATTCTTGCTCAGTCAAAAACACCTCTGCAATTAGGAATTTGGCGCTTTCTTTTTGGTTTTGGTACTGGAGCCCTCATGCCAAGTGTTAATGCTCTATTAACAAAACTAACACCTAAGGAAGGTATCTCTAGAATCTTTAGCTACAATCAGATGTTTACCAACTTTGGTCAGGTATTGGGCCCTTTTGTAGGATCGACTGTAGCAGCAGGCTGGGGTTATCGCTGGGTCTTTTATGCTACAGGAGCAATTGTTCTTTTCAATTTTATATGGAGTCTTGTTAATTTTAGAAAATATTTGAAAGTTAGGGAAATTTAG","10.90","16.18","42453","MIAWFGSFFTGASFSLVMPFMALFVEELGVKGDLVKLYAGLAVSISALASALFAPVWGRLADRYGRKPMMIRASLVMTFTMGGLAFVTDVYGLLFLRLLNGMFAGYVPNANALIASQAPKNESGSALGTLATGVIAGSLIGPLMGGMLAEFLGIRNVFLLVGTLLLLVMLLTTFFIQEDFRPVSKKDILSTKELFAQIKDRQILLGLFVTSMIIQISAQSVAPILALYIRYLGQRDNLMLIAGLIVSAMGFSSIISSSRFGKLGDKIGNHRMLLAGLFYCGIIYLILAQSKTPLQLGIWRFLFGFGTGALMPSVNALLTKLTPKEGISRIFSYNQMFTNFGQVLGPFVGSTVAAGWGYRWVFYATGAIVLFNFIWSLVNFRKYLKVREI","1540535","","multi-drug resistance efflux pump, major facilitator superfamily","Membrane, Extracellular","Several similarities in gapped BLAST to multi-drug resistance efflux pump. Residues 2-389 are 61% similar to gi15674606 from S.pyogenes and are 56% similar to gi15900849 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1485 (1e-137).","

InterPro
IPR001958
Family

Tetracycline resistance protein
PR01035	$\"[9-25]T$ $\"[39-58]T$ $\"[97-118]T$ $\"[127-149]T$ $\"[211-228]T$ $\"[269-290]T$ $\"[330-353]T$	TCRTETA

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[1-384]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[3-354]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[1-388]T$	MAJOR FACILITATOR SUPERFAMILY MEMBER
PTHR10074:SF30	$\"[1-388]T$	MULTIDRUG-EFFLUX TRANSPORTER
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[5-24]?$ $\"[38-58]?$ $\"[73-93]?$ $\"[126-146]?$ $\"[156-176]?$ $\"[238-258]?$ $\"[273-288]?$ $\"[298-318]?$ $\"[333-353]?$ $\"[359-379]?$	transmembrane_regions

","BeTs to 14 clades of COG0477COG name: PermeasesFunctional Class: G,E,RThe phylogenetic pattern of COG0477 is AMTKYQVCEBRHUJGPo-INXNumber of proteins in this genome belonging to this COG is 10","***** IPB002617 (Vesicular monoamine transporter) with a combined E-value of 1.8e-11. IPB002617B 35-84 IPB002617C 117-169 IPB002617E 265-310 IPB002617F 315-361***** IPB003662 (General substrate transporters) with a combined E-value of 9.8e-06. IPB003662A 296-328 IPB003662B 363-373","Residues 329-374 are 50% similar to a (ORF1 TRANSMEMBRANE PUMP COMPLETE) protein domain (PD078201) which is seen in YCEE_ECOLI.Residues 176-273 are 57% similar to a (PROTEOME BH2592 PUMP COMPLETE) protein domain (PD355641) which is seen in Q9ZEX9_STRPN.Residues 85-155 are 70% similar to a (COMPLETE TRANSMEMBRANE PROTEOME TRANSPORT) protein domain (PD000036) which is seen in Q9ZEX9_STRPN.Residues 326-389 are 51% similar to a (TRANSMEMBRANE 5'REGION MULTI-DRUG EFFLUX) protein domain (PD203864) which is seen in YRG1_LACLA.Residues 285-324 are 67% similar to a (TRANSMEMBRANE TRANSPORT TRANSPORTER) protein domain (PD197893) which is seen in Q9ZEX9_STRPN.Residues 203-279 are 48% similar to a (TRANSMEMBRANE TRANSPORT TRANSPORTER COMPLETE PROTEOME) protein domain (PD000082) which is seen in YRG1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 16:50:30 2002","Thu Sep 14 14:23:36 2006","Thu Sep 14 14:23:12 2006","Thu Mar 14 16:49:57 2002","Thu Mar 14 16:49:57 2002","Thu Sep 14 14:23:36 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1465 is paralogously related (blast p-value < 1e-3) to SMu1173, SMu1914, SMu1460, and SMu0119, all permease-related proteins and SMu1287 a predicted conserved hypothetical protein.","Thu Mar 14 16:49:57 2002","","No significant hits to the NCBI PDB database.","SMU.1611c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 16:49:57 2002","24379991","","","Sulavik MC, Houseweart C, Cramer C, Jiwani N, Murgolo N, Greene J, DiDomenico B, Shaw KJ, Miller GH, Hare R, Shimer G.Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.Antimicrob Agents Chemother. 2001 Apr;45(4):1126-36.PMID: 11257026 ","","Mon Mar 18 08:29:25 2002","1","","","SMU.1611c","425" "SMu1466","1542646","1541810","837","ATGAATGACATTTACTTTGATGACAACCGTCATAACTGGAATGATCGCGCTCGTCTGCATGAGGAAGCAGGTTATGGTATTGATAAACTCTTATCAGATAGAGACTATATCACACCAGAGGTTGAACAAGATAAAGACCTGATTGGTGACTTGACCAATAAAGATGTCCTGCATTTACAATGTCACTTGGGAACAGATACGATTAGTTTGGCGCGTTTAGGAGCTAGGCGCGTTCTTGGTTTGGATCTTTCTGATGAGTCATTAAGGCGTGCCAGAAATTTAGCTAAAAAGGCCGGTGTTTCTATTGATTTCATAGAGGGTAATGTTTACGATGCTAGAGAAGTCATTGTTGGTGATTTTGATCTGATCTATACTTCTCTGGGTGTCTTATGCTGGTTGCCGGATATTACTGCCTGGGGACGCGTTGTGGCTAGTTTACTGAAATCTGGCGGAAAATTTATTATTCGTGATGATCATCCCATGTTTATGACTATTGGGGAAGATGTTCGTGATGGCTTTAAAATTGAACAACCTTATTTCGAACAGTCACAACCTATGACTTGGGAAGATGAGGGCTCTTATATTGAAACAGATGCATCTTTTGAAAAAATTAAGAACACACGGAATCATCAATGGAATCATGCTCTCAGTGAAATTATTATGGCTTTGATTAATGCTGGTTTACAAATTGATTTGGTATCTGAATCCCAGCATGCTGCTTGGAATATTTGGCCTCATCTAATGGAAAAGTGCTCAGATGGCAGCTACCGACTCAAAAAGCACTCAGAAGTCTTACCCTTGCAATTTCTTATTTCAGCCCATAAGCCAGAAGCTTAG","5.00","-13.47","31754","MNDIYFDDNRHNWNDRARLHEEAGYGIDKLLSDRDYITPEVEQDKDLIGDLTNKDVLHLQCHLGTDTISLARLGARRVLGLDLSDESLRRARNLAKKAGVSIDFIEGNVYDAREVIVGDFDLIYTSLGVLCWLPDITAWGRVVASLLKSGGKFIIRDDHPMFMTIGEDVRDGFKIEQPYFEQSQPMTWEDEGSYIETDASFEKIKNTRNHQWNHALSEIIMALINAGLQIDLVSESQHAAWNIWPHLMEKCSDGSYRLKKHSEVLPLQFLISAHKPEA","1541826","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypothetical proteins. Residues 9-275 are 33% similar to gi|15212095| from Mycobacterium fortuitum. Residues 9-276 are 24% similar to gi|15597650| from Pseudomonas aeruginosa. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1658 (4e-05).","

InterPro
IPR013217
Domain

Methyltransferase type 12
PF08242	$\"[57-153]T$	Methyltransf_12

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[34-155]T$	G3DSA:3.40.50.150
PTHR10108	$\"[64-157]T$	PTHR10108
PTHR10108:SF26	$\"[64-157]T$	PTHR10108:SF26
SSF53335	$\"[1-277]T$	SSF53335

","BeTs to 3 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 120-239 are 29% similar to a (PROTEOME COMPLETE PA4800 PA2454) protein domain (PD279923) which is seen in Q9HV09_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:19:18 2002","Thu Mar 14 16:54:37 2002","Thu Mar 14 16:54:37 2002","Thu Mar 14 16:54:37 2002","","Thu Mar 14 16:54:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1466 is paralogously related (blast p-value < 1e-3) to SMu1634, a predicted conserved hypothetical protein; possible methyltransferase.","Thu Mar 14 16:54:37 2002","","No significant hits to the NCBI PDB database.","SMU.1612c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 16:54:37 2002","24379992","","","","","","1","","","SMU.1612c","" "SMu1467","1543235","1542639","597","ATGACAAAAATTATTGGGATTACAGGCGGTATCGCTTCTGGTAAGTCAACGATTACAAATTATCTCAGGCAAAAGGGTTATCAAGTTATTGATGCTGACCAAGTCGTGCATGATTTACAGGCTAATGGTGGTAGGCTTTATCAGGCCTTGGTCAACTGGCTGGGCACAGCTATTCTCAATGAAGCAGGCGAACTCAATCGTCCGAAATTGTCCCAACTCATTTTTTCCAGTCCAGACAATTTAGCCAAATCTTCTCAGCTACAAAATGCTATTATCAGACAGGAGTTGGAGACTAGACGAGACCAGCTAGCTAAAACAGAGGCAATTTTCTTTATGGATATTCCGCTTTTGATTGAGCAGAACTATAGGGACTGGTTTGATGAGATCTGGTTAATAGCGGTAAGCCCAGAGACACAAATCAAGCGGTTGAAGCAGCGAAATGGTTATTCGCAAGAAGAAGCGCAGCAGCGCCTTGCCAGCCAAATGCCCTTGCAGGCCAAAAAAGTTTATGCCGATCAAATAATTGATAATAATAAAACAGTTGAAAATACTAAAATGCAAGTGGACAGTCAACTGAGGAGGTTGCAAAATGAATGA","9.00","1.24","22618","MTKIIGITGGIASGKSTITNYLRQKGYQVIDADQVVHDLQANGGRLYQALVNWLGTAILNEAGELNRPKLSQLIFSSPDNLAKSSQLQNAIIRQELETRRDQLAKTEAIFFMDIPLLIEQNYRDWFDEIWLIAVSPETQIKRLKQRNGYSQEEAQQRLASQMPLQAKKVYADQIIDNNKTVENTKMQVDSQLRRLQNE","1542655","","dephospho-CoA kinase","Cytoplasm, Periplasm","Matches in gapped BLAST to conserved hypothetical protein and kinase:residues 4-197 are 57% similar to gi15674604 from S.pyogenes and residues 1-178 are 61% similar to gi15900848 from S.pneumoniae The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1488 (2e-67).","

InterPro
IPR001977
Family

Dephospho-CoA kinase
PD003329	$\"[4-113]T$	Depp_CoAkinase
PTHR10695	$\"[77-196]T$	Depp_CoAkinase
PF01121	$\"[3-182]T$	CoaE
TIGR00152	$\"[4-190]T$	Depp_CoAkinase
PS51219	$\"[4-198]T$	DPCK

noIPR
unintegrated

unintegrated
SSF52540	$\"[2-195]T$	SSF52540

","BeTs to 12 clades of COG0237COG name: Predicted ATPaseFunctional Class: RThe phylogenetic pattern of COG0237 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001977 (Uncharacterized protein family UPF0038) with a combined E-value of 1.1e-47. IPB001977A 5-34 IPB001977B 54-92 IPB001977C 107-122 IPB001977D 142-179***** PR00988 (Uridine kinase signature) with a combined E-value of 7.8e-06. PR00988A 2-19","Residues 4-178 are 60% similar to a (KINASE ATP-BINDING TRANSFERASE COENZYME) protein domain (PD003329) which is seen in COAE_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 18 08:25:49 2002","Thu Jul 13 11:22:00 2006","Thu Jul 13 11:19:56 2006","Thu Mar 14 16:58:20 2002","Thu Mar 14 16:58:20 2002","Thu Mar 14 16:58:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1467 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 18 08:25:49 2002","","No significant hits to the NCBI PDB database.","SMU.1613c","","Residues 3 to 182 (E-value = 9.1e-52) place SMu1467 in the CoaE family which is described as Dephospho-CoA kinase (PF01121)","Thu Mar 14 16:58:20 2002","24379993","","","","","","1","","","SMU.1613c","834" "SMu1468","1544053","1543232","822","ATGCCAGAATTACCAGAGGTTGAAACAGTCAGGCGTGGCTTAGAGCATTTGATTGTTGGCAAAAAAATTGTATCGGTAGAGGTTCGTGTGCCCAAAATGGTCAAAACGGGTGTAGAAGATTTTCAGCTGGACATTTTAGGACAAACCTTTGAAAGTATTGGCCGTCGTGGCAAATATCTTCTTTTAAATCTCAACAGGCAGACCATTATTTCTCATCTGCGCATGGAAGGAAAGTATTTGCTTTTTGAAGATGAGGTACCGGACAATAAGCATTTTCATCTTTTCTTTGGTCTGGATGGTGGGTCAACCTTGGTCTATCAGGATGTCCGCAAATTTGGTACTTTTGAATTATTGCCTAAAAGTCAGGTTGAAGCTTATTTTGTTCAGAAAAAAATTGGTCCTGAGCCAAATGCCAAAGATTTTAAACTCAAGCCTTTTGAAGAAGGACTGGCCAAATCACACAAGGTCATCAAAACACTACTTTTGGATCAGCATTTAGTGGCTGGACTTGGCAATATTTATGTGGACGAAGTGCTCTGGGCAGCAAAAGTCGATCCAGAACGGCTAGCCAGTCAACTGAAAAAATCAGAAATCAAACGGATTCATGATGAAACCATCCGTATTCTGCAACTGGCTATTGAAAAGGGAGGCTCGACTATTCGTAGCTATAAGAATAGCTTGGGTGAAGATGGCAGTATGCAGGATTGCTTACAAGTTTATGGAAAGACAGATCAGCCTTGTGCTCGCTGTGCCACGCCTATTGAGAAAATTAAAGTAGGAGGGAGAGGGACGCATTTTTGCCCGTCCTGCCAAAAACAATGA","8.90","6.70","30861","MPELPEVETVRRGLEHLIVGKKIVSVEVRVPKMVKTGVEDFQLDILGQTFESIGRRGKYLLLNLNRQTIISHLRMEGKYLLFEDEVPDNKHFHLFFGLDGGSTLVYQDVRKFGTFELLPKSQVEAYFVQKKIGPEPNAKDFKLKPFEEGLAKSHKVIKTLLLDQHLVAGLGNIYVDEVLWAAKVDPERLASQLKKSEIKRIHDETIRILQLAIEKGGSTIRSYKNSLGEDGSMQDCLQVYGKTDQPCARCATPIEKIKVGGRGTHFCPSCQKQ","1543248","For other 'mut' genes associated with repair and DNA mutation, see Smu0510; SMu0024 (mutT); SMu1697 (mutY);SMu1700 (mutS2);SMu1291 (mutT); SMu1325 (mutX); SMu1371 (mutR); SMu1468 (mutM); SMu0824 (mutT) and SMu0825 (mutT).","formamidopyrimidine-DNA glycosylase","Cytoplasm, Extracellular","Matches in gapped BLAST to formamidopyrimidine-DNA glycosylase :residues 1-273 are 99% similar to the previously published enzyme in S.mutans (gi1706893) and (gi475032). Residues 1-273 are 68% similar to formamidopyrimidine-DNA glycosylase in S.pyogenes (gi15674603) The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1489 (1e-107).","

InterPro
IPR000191
Family

Formamidopyrimidine-DNA glycolase
PD003680	$\"[140-218]T$	Fapy_DNA_glyco
PF01149	$\"[2-116]T$	Fapy_DNA_glyco
PF06831	$\"[132-224]T$	H2TH

InterPro
IPR000214
Binding_site

Formamidopyrimidine-DNA glycolase, zinc-binding site
PS01242	$\"[247-271]T$	ZF_FPG_1
PS51066	$\"[238-272]T$	ZF_FPG_2

InterPro
IPR010663
Domain

Zinc finger, Fpg-type
PF06827	$\"[244-273]T$	zf-FPG_IleRS

InterPro
IPR010979
Domain

Ribosomal protein S13-like, H2TH
SSF46946	$\"[131-222]T$	Ribosomal_H2TH

InterPro
IPR012319
Domain

Formamidopyrimidine-DNA glycosylase, catalytic
PS51068	$\"[2-113]T$	FPG_CAT

noIPR
unintegrated

unintegrated
PTHR22993	$\"[19-273]T$	PTHR22993
PTHR22993:SF4	$\"[19-273]T$	PTHR22993:SF4
SSF57716	$\"[220-272]T$	SSF57716
SSF81624	$\"[2-141]T$	SSF81624

","BeTs to 5 clades of COG0266COG name: Formamidopyrimidine-DNA glycosylaseFunctional Class: LThe phylogenetic pattern of COG0266 is -------cEbRh--gp-----Number of proteins in this genome belonging to this COG is 1","***** IPB000214 (Formamidopyrimidine-DNA glycolase, zinc binding domain) with a combined E-value of 1.2e-69. IPB000214A 1-13 IPB000214B 55-79 IPB000214C 104-113 IPB000214D 161-186 IPB000214E 240-271","Residues 1-271 are 99% similar to a (GLYCOSYLASE GLYCOSIDASE FORMAMIDOPYRIMIDINE-DNA) protein domain (PD003680) which is seen in FPG_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 13:53:20 2006","Thu Mar 14 17:02:10 2002","Wed Jan 12 10:19:42 2005","Thu Mar 14 17:02:10 2002","Thu Mar 14 17:02:10 2002","Thu Mar 14 17:02:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1468 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 17:04:19 2002","Wed Jan 12 10:19:42 2005","pdb1EE8A Chain A, Crystal Structure Of Mutm (Fpg) Protein Fro... 164 1e-041","SMU.1614c","","Residues 1 to 118 (E-value = 5.8e-66) place SMu1468 in the Fapy_DNA_glyco family which is described as Formamidopyrimidine-DNA glycosylase N-terminal domain (PF01149)Residues 132 to 224 (E-value = 2.2e-49) place SMu1468 in the H2TH family which is described as Formamidopyrimidine-DNA glycosylase H2TH domain (PF06831)Residues 244 to 273 (E-value = 2.9e-10) place SMu1468 in the zf-FPG_IleRS family which is described as Zinc finger found in FPG and IleRS (PF06827)","Wed Jan 12 10:19:42 2005","","","","Boiteux,S., O'Connor,T.R. and Laval,J.Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloningand sequencing of the fpg structural gene and overproduction of the proteinEMBO J. 6 (10), 3177-3183 (1987)PubMed: 3319582O'Connor,T.R., Graves,R.J., de Murcia,G., Castaing,B. and Laval,J.Fpg protein of Escherichia coli is a zinc finger protein whosecysteine residues have a structural and/or functional roleJ. Biol. Chem. 268 (12), 9063-9070 (1993)PubMed: 8473347","Wed Jan 12 10:19:42 2005","Thu Sep 28 13:53:20 2006","1","","","SMU.1614c","426" "SMu1469","1544628","1544104","525","ATGGACTATTTAGATATGTTAATTGATAGTCTCAATCGGGTTAGAGAACGTTTTTGGCGTATGTTTAAAGGAGTGACAGTAGAGCAAGCTAATTGTTTCCCAGTTGCTGATACTGCACCGCAGATAAAATCACTGACTTGGCTAGCATGGCATACAGCGCGTGAATTGGATTTGCAGATTTCAGCTTTGGCAGGGCAGGAGTCCATCTGGGACAGTCAAGGTTTTAAAGAGTATTTTCCTTTTGAAGTGGCAGAAACAGAAGACGGTTGGGATCACAGCTTAGAGCAAGCTCAAAAAATTAAGGTCGATCACTTAGATGATGTTTTAGATTATCTCAATGATGCTACAGATTTTGCCATTCTTTACCTGAAATCACTTAATCCAGAATGTCTAGATGATATTGTAGATGATTCTTGGACACCAGCTGTGACGCGTGGTGTACGCTTGGTTTCCATCATTGATGATGCTGCTATGCACTCAGGACAAGCTATTTATGCTCGTCGTTTGCTTGGTTTGAAGGATTAG","4.30","-14.13","19925","MDYLDMLIDSLNRVRERFWRMFKGVTVEQANCFPVADTAPQIKSLTWLAWHTARELDLQISALAGQESIWDSQGFKEYFPFEVAETEDGWDHSLEQAQKIKVDHLDDVLDYLNDATDFAILYLKSLNPECLDDIVDDSWTPAVTRGVRLVSIIDDAAMHSGQAIYARRLLGLKD","1544120","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to hypotheticals and conserved hypotheticals:residues 5-167 are 32% similar to gi|15839831| from Mycobacterium tuberculosis and residues 5-170 are 30% similar to gi|7479626| from S.coelicolorSMu1469 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF109854	$\"[1-173]T$	SSF109854

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-167 are 32% similar to a (PROTEOME COMPLETE) protein domain (PD098493) which is seen in O53728_MYCTU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:17:54 2002","Thu Mar 14 17:07:52 2002","Wed Oct 9 08:17:54 2002","Thu Mar 14 17:07:52 2002","","Thu Mar 14 17:07:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1469 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:17:54 2002","","No significant hits to the NCBI PDB database.","SMU.1615c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 17:07:52 2002","24379995","","","","","","1","","","SMU.1615c","" "SMu1470","1545198","1544728","471","ATGGACTATATTTCCTACATCCGCTCAAAAGTCGGTCATGACAAGGTTATCTTGACTTTTGCTGGCGGGATTTTAGCAGACAAAGACGGGCGTGTGCTTTTGCAACTGCGCGGAGATAAGAAGACTTGGGCTATTCCGGGCGGTGCAATGGAGCTGGGCGAATCTACGCTTGACACAGCTAAACGTGAATTTTTTGAAGAAACAGGTATCAAGGTGGAGGCTGTGTGCTTTCTTAATGTTTATAGCCATTTTGAGGAAGTCTATCCTAATGGTGATGAGGTGCAGACTATTGTCATGATTTATGAGTTTAAGGCGCTAAATGACTTTGATATTTCTGATTTTCACAATGAAGAAACCTTGCGCCTGCGTTTCTTTTCTGAGGAAGAAATAGCGAAGCTGGAATCGGTTAGTGACAAGCATCGCCTGATGTTGGCTGAGTATTTTGATGACAGCTTTGCATTGGGACATTAA","4.60","-11.83","17870","MDYISYIRSKVGHDKVILTFAGGILADKDGRVLLQLRGDKKTWAIPGGAMELGESTLDTAKREFFEETGIKVEAVCFLNVYSHFEEVYPNGDEVQTIVMIYEFKALNDFDISDFHNEETLRLRFFSEEEIAKLESVSDKHRLMLAEYFDDSFALGH","1544744","","phosphohydrolase MutT/nudix family protein ","Cytoplasm","Matches very weakly to MutX:residues 29-104 are 31% similar to the previously published enzyme in S.mutans (gi1813348) and (gi2497998) Limited matches in gapped BLAST to conserved hypothetical proteins:residues 2-156 are 77% similar to the protein in S.pyogenes (gi15674593).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1505 (7e-51).","

InterPro
IPR000086
Domain

NUDIX hydrolase
PR00502	$\"[43-57]T$ $\"[57-72]T$	NUDIXFAMILY
G3DSA:3.90.79.10	$\"[6-133]T$	NUDIX_hydrolase
PF00293	$\"[17-150]T$	NUDIX
PS00893	$\"[48-69]T$	NUDIX

InterPro
IPR015797
Domain

NUDIX
SSF55811	$\"[1-149]T$	NUDIX_hydrolase

noIPR
unintegrated

unintegrated
PTHR22769	$\"[23-130]T$	PTHR22769

","BeTs to 5 clades of COG1051COG name: ADP-ribose pyrophosphataseFunctional Class: FThe phylogenetic pattern of COG1051 is amtk-q-C--r----------Number of proteins in this genome belonging to this COG is 1","***** IPB000086 (NUDIX hydrolase) with a combined E-value of 5.1e-11. IPB000086 43-69","Residues 3-82 are 45% similar to a (COMPLETE PROTEOME HYDROLASE MUTATOR MUTT/NUDIX FAMILY) protein domain (PD000653) which is seen in Q9KBN2_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 17:16:14 2002","Thu Mar 1 12:39:11 2007","Thu Mar 1 12:39:11 2007","Thu Mar 14 17:15:53 2002","Thu Mar 14 17:15:53 2002","Thu Mar 14 17:15:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1470 is paralogously related (blast p-value < 1e-3) to SMu0738,a predicted mutator MutT protein; SMu0510,a predicted mutator protein and SMu1325, a predicted mutator mutX protein.","Thu Mar 14 17:15:53 2002","","No significant hits to the NCBI PDB database.","SMU.1616c","","Residues 17 to 150 (E-value = 5.7e-18) place SMu1470 in the NUDIX family which is described as NUDIX domain (PF00293)","Thu Mar 14 17:15:53 2002","24379996","","","","","","1","","","SMU.1616c","" "SMu1471","1546142","1545243","900","ATGTCATTTAAATCAGGATTTGTAGCTATTTTAGGTCGTCCCAATGTTGGGAAATCGACCTTTTTAAATCATGTCATGGGGCAAAAAATTGCTATCATGTCTGATAAGGCACAAACAACCCGTAATAAAATTATGGGAATTTATACTACAGATAAAGAGCAAATCGTTTTTATTGATACGCCTGGTATTCATAAACCGAAAACTGCCTTAGGTGATTTTATGGTTGAGTCTGCCTATTCAACCCTGCGTGAAGTGGACACAGTTCTTTTTATGGTACCTGCTGATGAAAAGCGGGGTAAAGGCGACAATATGATTATAGAGCGTCTTAAAGCGGCCAAGGTACCTGTTATTTTGGTTATCAATAAGATTGATAAGGTTCATCCGAATCAATTACTCGAACAGATTGATGATTTTAGAAATCAAATGGATTTTCAAGAAATTGTCCCTATTTCTGCCTTGCAAGGCAATAATGTCAGTCATCTGGTAGATCTTTTGGTAGATCATCTAGAAGAAGGTTTTCAATATTTTCCAGCTGATCAAATCACAGATCATCCAGAGCGCTTTTTGGTATCTGAAATGATTCGGGAAAAAGTTTTGTTGCTGACGCGTGAAGAAATTCCTCATTCGGTAGCTGTGGTTATTGACTCAATGGCGCGTGATGAGGAAACGCATAAGATACATATTCGTGCGACCATTATGGTGGAGCGTGACAGTCAAAAGGGCATTATCATCGGTAAAAAGGGTGCTATGCTTAAAAAGATAGGCCAAATGGCTCGTCGTGACATCGAACTCATGCTAGGTGACAAAGTCTACCTCGAAACATGGGTCAAGGTCAAGAAAAACTGGCGCGATAAGAAACTAGACTTAGCCGATTTTGGGTATAATAAGAAGGAGTATTGA","8.80","3.18","34177","MSFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEKRGKGDNMIIERLKAAKVPVILVINKIDKVHPNQLLEQIDDFRNQMDFQEIVPISALQGNNVSHLVDLLVDHLEEGFQYFPADQITDHPERFLVSEMIREKVLLLTREEIPHSVAVVIDSMARDEETHKIHIRATIMVERDSQKGIIIGKKGAMLKKIGQMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNKKEY","1545259","","GTP-binding protein era homolog.","Cytoplasm","This sequence corresponds to the previously sequenced gi585107 and (gi2749952) in GenBank. In addition, residues 1-299 are 89% similar to gi13959367 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1499 (1e-151).","

InterPro
IPR001220
Domain

Legume lectin, beta domain
PS00307	$\"[210-216]F$	LECTIN_LEGUME_BETA

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[6-124]T$	MMR_HSR1

InterPro
IPR004044
Domain

KH, type 2
PF07650	$\"[230-294]T$	KH_2
PS50823	$\"[202-280]T$	KH_TYPE_2

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[3-167]T$	small_GTP

InterPro
IPR005289
Domain

GTP-binding
TIGR00650	$\"[11-62]T$	MG442

InterPro
IPR005662
Family

GTP-binding protein Era
TIGR00436	$\"[6-277]T$	era

InterPro
IPR009019
Domain

KH, prokaryotic type
G3DSA:3.30.300.20	$\"[185-298]T$	KH_prok
SSF54814	$\"[179-292]T$	KH_prok

noIPR
unintegrated

unintegrated
PTHR11649	$\"[1-285]T$	PTHR11649
PTHR11649:SF3	$\"[1-285]T$	PTHR11649:SF3
SSF52540	$\"[2-208]T$	SSF52540

","BeTs to 10 clades of COG1159COG name: Predicted GTPases, Era/HflX familyFunctional Class: RThe phylogenetic pattern of COG1159 is -m-k-QVCEBRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000765 (GTP1/OBG family) with a combined E-value of 1.2e-16. IPB000765 6-49***** PR00449 (Transforming protein P21 RAS signature) with a combined E-value of 5.6e-07. PR00449A 6-27 PR00449D 112-125 PR00449E 147-169","Residues 172-279 are identical to a (GTP-BINDING RNA-BINDING HOMOLOG MEMBRANE) protein domain (PD004541) which is seen in ERA_STRMU.Residues 8-62 are 43% similar to a (AIG1-LIKE CHLOROPLAST OUTER GTP-BINDING) protein domain (PD038841) which is seen in Q9CZU4_MOUSE.Residues 74-158 are 37% similar to a (GTP-BINDING RNA-BINDING PHOSPHORYLATION) protein domain (PD414467) which is seen in ERA_SALTY.Residues 65-158 are 35% similar to a (GTP-BINDING RNA-BINDING HOMOLOG) protein domain (PD272762) which is seen in ERA_MYCLE.Residues 192-283 are 50% similar to a (GTP-BINDING RNA-BINDING HOMOLOG) protein domain (PD328893) which is seen in ERA_MYCLE.Residues 64-130 are 34% similar to a (GTP-BINDING ERA RNA-BINDING HOMOLOG) protein domain (PD395466) which is seen in ERA_SYNY3.Residues 8-63 are identical to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in ERA_STRPN.Residues 82-159 are 98% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in ERA_STRMU.Residues 280-299 are identical to a (GTP-BINDING RNA-BINDING HOMOLOG) protein domain (PD403309) which is seen in ERA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 17:24:46 2002","Thu Mar 14 17:19:24 2002","Thu Sep 14 14:30:03 2006","Thu Mar 14 17:19:24 2002","Thu Mar 14 17:19:24 2002","Thu Mar 14 17:19:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1471 is paralogously related (blast p-value < 1e-3) to SMu1744, a predicted phosphoglycerate dehydrogenase; SMu1130,a predicted thiophene and furan oxidation protein; SMu0382, a predicted translation initiation factor 2; SMu0903,SMu1343,SMu0862 and SMu0727,predicted GTP-binding proteins; SMu0554,predicted peptide chain release factor 3;translation elongation and release factor and SMu0519, a predicted ferrous ion transport protein B.","Thu Mar 14 17:27:00 2002","Thu Sep 14 14:30:03 2006","pdb1EGAB Chain B, Crystal Structure Of A Widely Conserved Gtp... 229 3e-061","SMU.1617c","","Residues 8 to 177 (E-value = 3.1e-06) place SMu1471 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)Residues 232 to 284 (E-value = 6.5e-05) place SMu1471 in the KH family which is described as KH domain (PF00013)","Thu Sep 14 14:30:03 2006","","","Yamashita,Y., Takehara,T. and Kuramitsu,H.K.Molecular characterization of a STreptococcus mutans mutant altered in environmental stress responsesJ. Bacteriol. 175 (19), 6220-6228 (1993)PubMed: 8407794","Zhao,G., Meier,T.I., Peery,R.B., Matsushima,P. and Skatrud,P.L.Biochemical and molecular analyses of the C-terminal domain of EraGTPase from Streptococcus pneumoniaeMicrobiology 145 (Pt 4), 791-800 (1999)PubMed: 10220158","Thu Mar 14 17:19:24 2002","Thu Mar 14 17:24:46 2002","1","","","SMU.1617c","427" "SMu1472","1546576","1546163","414","ATGCCTATGGACTTAAGAGATAATAAGCAAAGCCAAAAGAAATGGAAAAATAGAACTTTAACTTCCAGCCTTGAATTCGCTTTAACGGGGATTTTTACGGCTTTTAAAGAAGAGCGTAATATGAAAAAACATGCAGTGTCAGCTCTTTTAGCTGTCATTGCTGGTTTGGTTTTTAAAGTATCAGTCATTGAGTGGCTTTTTCTTTTATTAAGTATTTTTTTGGTTATTACCTTTGAAATTGTCAATTCGGCTATTGAAAATGTGGTTGATTTGGCCAGTGACTATCATTTTTCCATGTTGGCTAAAAATGCTAAGGATATGGCTGCAGGAGCTGTTCTTGTCATTTCAGGTTTTGCTGCCTTGACAGGCTTGATTATTTTTGTACCAAAAATTTGGTTTTTGCTTTTTCATTAA","10.10","3.71","15334","MPMDLRDNKQSQKKWKNRTLTSSLEFALTGIFTAFKEERNMKKHAVSALLAVIAGLVFKVSVIEWLFLLLSIFLVITFEIVNSAIENVVDLASDYHFSMLAKNAKDMAAGAVLVISGFAALTGLIIFVPKIWFLLFH","1546179","","diacylglycerol kinase","Membrane, Cytoplasm","This sequence corresponds to the previously sequenced gi|2749951| and gi|541362| in GenBank. In addition, residues 3-137 are 77% similar to gi|15674591| from S.pyogenesThe best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1500 (1e-56).","

InterPro
IPR000829
Family

Prokaryotic diacylglycerol kinase
PD010722	$\"[68-134]T$	KDGL_STRMU_Q05888;
PF01219	$\"[20-127]T$	DAGK_prokar
PS01069	$\"[79-90]T$	DAGK_PROKAR

InterPro
IPR014429
Family

Diacylglycerol kinase, firmicute
PIRSF005085	$\"[3-137]T$	Diacylglycerol kinase, Firmicutes type

noIPR
unintegrated

unintegrated
tmhmm	$\"[49-69]?$ $\"[108-128]?$	transmembrane_regions

","BeTs to 5 clades of COG0818COG name: Diacylglycerol kinaseFunctional Class: MThe phylogenetic pattern of COG0818 is ------vceb-huj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000829 (Prokaryotic diacylglycerol kinase) with a combined E-value of 2.7e-44. IPB000829A 19-63 IPB000829B 64-110","Residues 30-131 are 98% similar to a (KINASE DIACYLGLYCEROL PROTEOME COMPLETE) protein domain (PD010722) which is seen in KDGL_STRMU.Residues 1-29 are identical to a (KINASE TRANSFERASE DIGLYCERIDE) protein domain (PD030032) which is seen in KDGL_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 17:32:10 2002","Wed Apr 24 16:27:39 2002","Thu Oct 17 10:38:54 2002","Thu Mar 14 17:31:21 2002","Thu Mar 14 17:31:21 2002","Thu Mar 14 17:31:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1472 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 17:32:10 2002","","No significant hits to the NCBI PDB database.","SMU.1618c","","Residues 20 to 127 (E-value = 2.5e-61) place SMu1472 in the DAGK_prokar family which is described as Prokaryotic diacylglycerol kinase (PF01219)","Thu Mar 14 17:31:21 2002","","","Chen,P., Novak,J., Qi,F. and Caufield,P.W.Diacylglycerol kinase is involved in regulation of expression ofthe lantibiotic mutacin II of Streptococcus mutansJ. Bacteriol. 180 (1), 167-170 (1998)PubMed: 9422608","Smith,R.L., O'Toole,J.F., Maguire,M.E. and Sanders,C.R. II.Membrane topology of Escherichia coli diacylglycerol kinaseJ. Bacteriol. 176 (17), 5459-5465 (1994)PubMed: 8071224","Thu Mar 14 17:31:21 2002","Thu Oct 17 10:38:54 2002","1","","","SMU.1618c","835" "SMu1473","1547048","1546554","495","ATGTATATTGAAATGATTGATGAGACGAATCAGGTTTCTGAGGAAATAAAAAACCAAACTTTGGATATTTTGGAATTCGCAGCACAAAAAACAGGGAAAGAAGACAAAGAAATGGCGGTTACTTTTGTGACCAATGAGCGCAGCCATGAACTGAATCTCAAGTATCGTGATACTAATCGTCCTACTGATGTTATCAGTCTAGAATACAAACCAGAAAGCTCCCTTTCTTTTGATGAGGAAGACTTGGCCGACGATCCAGATTTAGCCGAGGTATTAACTGAATTTGATGCTTATATTGGTGAATTATTTATTTCTGTCGATAAAGCTCGCGAACAGGCGCAAGAATATGGTCACTCATTTGAGCGTGAGATGGGCTTTTTGGCAGTACATGGCTTTTTACATATCAATGGTTATGACCACTACACTCCCCAAGAAGAAAAAGAGATGTTTAGCTTACAGGAAGAGATATTAGATGCCTATGGACTTAAGAGATAA","4.20","-22.77","19087","MYIEMIDETNQVSEEIKNQTLDILEFAAQKTGKEDKEMAVTFVTNERSHELNLKYRDTNRPTDVISLEYKPESSLSFDEEDLADDPDLAEVLTEFDAYIGELFISVDKAREQAQEYGHSFEREMGFLAVHGFLHINGYDHYTPQEEKEMFSLQEEILDAYGLKR","1546570","This sequence corresponds to the previously sequenced gi|2749950| in GenBank. ","conserved hypothetical protein","Cytoplasm","Residues 1-164 are 77% similar to gi|15674590| from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1501 (1e-71).","

InterPro
IPR002036
Family

Protein of unknown function UPF0054
PD005688	$\"[51-156]T$	UPF0054
PF02130	$\"[43-158]T$	UPF0054
TIGR00043	$\"[36-161]T$	UPF0054
PS01306	$\"[130-140]T$	UPF0054

noIPR
unintegrated

unintegrated
G3DSA:3.40.390.30	$\"[5-164]T$	G3DSA:3.40.390.30
SSF55486	$\"[3-162]T$	SSF55486

","BeTs to 12 clades of COG0319COG name: Uncharacterized BCR (putative metal-binding protein)Functional Class: SThe phylogenetic pattern of COG0319 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002036 (Uncharacterized protein family UPF0054) with a combined E-value of 5.6e-40. IPB002036A 37-63 IPB002036B 99-145","Residues 16-164 are 91% similar to a (COMPLETE PROTEOME BB0060 CJ0121 SLR0053 TC0705 BU442) protein domain (PD005688) which is seen in O51806_STRMU.Residues 51-158 are 36% similar to a (MG388 UU490 COMPLETE D02_ORF108) protein domain (PD029948) which is seen in Q9PQ00_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:15:46 2002","Thu Mar 14 17:34:15 2002","Wed Oct 9 08:15:46 2002","Thu Mar 14 17:34:15 2002","Thu Mar 14 17:34:15 2002","Thu Mar 14 17:34:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1473 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 17:35:23 2002","","No significant hits to the NCBI PDB database.","SMU.1619c","","Residues 43 to 158 (E-value = 7.3e-29) place SMu1473 in the UPF0054 family which is described as Uncharacterized protein family UPF0054 (PF02130)","Thu Mar 14 17:34:15 2002","24379999","","","","Wed Oct 9 08:16:13 2002","","1","","","SMU.1619c","702" "SMu1474","1548417","1547452","966","TTGCAAGAGTATTCTGTTGAAGTGGCCTTGGTTCATCCAGATGATATGGTCAATTTATTTGGTTCTAATGAGCGGCATTTAAAATTAATTGAGGAGAATCTTGGTGTTGTCATTCATGCCAGGACAGAGCGCGTCCAGATTTTAGGTGAGACTGAGGAAGCCATTGAATTAGCTCGCCTGACCATCAAAGCGCTGTTAGTTCTAGTCGGACGGGGAATGATTGTCAATACTTCTGATGTTGTGACAGCACTTTCGATGGCGCAAAATGGCAATATTGATAAATTTGTGGCACTTTACGAAGAAGAAATTATCAAGGATTCTTATGGTAAACCCATTCGCGTTAAAACGCTAGGTCAAAAGGTCTATGTTGATAGCGTCAAAAGCCATGATATCGTTTTTGGTATTGGTCCTGCAGGAACGGGGAAAACATTTTTAGCAGTTACCCTAGCTATCACTGCCCTTAAACGTGGACAAGTCAAACGCATTATTCTAACACGTCCTGCAGTGGAGGCGGGTGAAAGTCTTGGTTTCTTACCAGGAGATCTTAAGGAAAAAGTTGATCCCTATCTGCGTCCTGTTTATGATGCTCTCTATCAGATTCTGGGGAAAGAGCAAACCAGTCGTCTCATGGAGCGTGAGATTATTGAAATTGCACCTTTGGCTTATATGCGCGGTCGAACTTTGGACGATGCTTTTGTCATTCTGGATGAAGCGCAGAATACTACCATCATGCAGATGAAGATGTTTTTGACTCGTCTTGGCTTTAATTCCAAGATGATTGTCAATGGTGATATTAGTCAGATTGATTTGCCTAAAAATGTCAAATCAGGCTTGGTTGATGCTTCAGAAAAACTAAAGGATATTAAACAGATCGATTTCGTCTATCTTTCTGCTAAAGACGTTGTCCGACATCCAGTGGTTGCTGAAATCATCAATGCTTATGAGGAGTCAACTGATGTCCGTTAG","5.60","-4.77","35726","MQEYSVEVALVHPDDMVNLFGSNERHLKLIEENLGVVIHARTERVQILGETEEAIELARLTIKALLVLVGRGMIVNTSDVVTALSMAQNGNIDKFVALYEEEIIKDSYGKPIRVKTLGQKVYVDSVKSHDIVFGIGPAGTGKTFLAVTLAITALKRGQVKRIILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQILGKEQTSRLMEREIIEIAPLAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFNSKMIVNGDISQIDLPKNVKSGLVDASEKLKDIKQIDFVYLSAKDVVRHPVVAEIINAYEESTDVR","1547468","For other 'pho'genes see SMu0946 (phoR) and SMu1035 (phoU).","phosphate starvation-induced protein","Cytoplasm","Several matches in gapped BLAST to phosphate starvation-induced protein: residues 1-319 are 84% similar to the enzyme in S.pyogenes (gi|15674588|) and are 82% similar to the protein from S.pneumoniae (gi|15900827|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1507 (1e-164).","

InterPro
IPR003714
Family

PhoH-like protein
PF02562	$\"[111-315]T$	PhoH

InterPro
IPR004087
Domain

KH
SM00322	$\"[3-67]T$	KH

InterPro
IPR004088
Domain

KH, type 1
PF00013	$\"[6-62]T$	KH_1

","BeTs to 6 clades of COG1702COG name: Phosphate starvation-inducible protein PhoH, predicted ATPaseFunctional Class: TThe phylogenetic pattern of COG1702 is -----qvcEbr----------Number of proteins in this genome belonging to this COG is 1","***** IPB003714 (PhoH-like protein) with a combined E-value of 6.6e-131. IPB003714A 122-163 IPB003714B 164-195 IPB003714C 215-255 IPB003714D 256-291 IPB003714E 300-314 IPB003714A 99-140","Residues 130-284 are 87% similar to a (PROTEOME COMPLETE ATP-BINDING PHOH-LIKE) protein domain (PD007750) which is seen in Q9CGL2_LACLA.Residues 5-129 are 52% similar to a (PHOH-LIKE PROTEOME ATP-BINDING COMPLETE) protein domain (PD191206) which is seen in Q9CGL2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 10:37:48 2002","Thu Mar 14 17:38:27 2002","Thu Oct 17 10:37:48 2002","Thu Mar 14 17:38:27 2002","Thu Mar 14 17:38:27 2002","Thu Mar 14 17:38:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1474 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 17:40:19 2002","","No significant hits to the NCBI PDB database.","SMU.1620c","","Residues 2 to 315 (E-value = 4.5e-162) place SMu1474 in the PhoH family which is described as PhoH-like protein (PF02562)","Thu Mar 14 17:38:27 2002","","","","Antelmann H, Scharf C, Hecker M.Phosphate starvation-inducible proteins of Bacillus subtilis: proteomics and transcriptional analysis.J Bacteriol. 2000 Aug;182(16):4478-90.PMID: 10913081 ","","Mon Mar 18 08:21:13 2002","1","","","SMU.1620c","428" "SMu1475","1548699","1548484","216","ATGAGAAAATCATTTTATACTTGGCTAATGACACAAAGGCACCCTAAGAGTCACGATCCTGTAGCTATTTTGGCGGATTTGGTCTTTGAAGATACGACTTTTCCGAAACACACGGATAGTTTTGAAAGGGTCAGTCGCTATTTAGAAGATGAAGCTAGTTTTTCTTTTAATCTTAGCGAATTTGACAGGATTTGGGAAGATTATTTGGCACATTAA","5.10","-4.05","8585","MRKSFYTWLMTQRHPKSHDPVAILADLVFEDTTFPKHTDSFERVSRYLEDEASFSFNLSEFDRIWEDYLAH","1548500","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-71 are 81% similar to S.pyogenes gi|15674585| and 70% similar to S.pneumoniae gi|15900826|.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1509 (3e-30).","

InterPro
IPR010673
Family

Protein of unknown function DUF1250
PF06855	$\"[4-69]T$	DUF1250

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-68 are 49% similar to a (PROTEOME COMPLETE YUIB YOZE) protein domain (PD056946) which is seen in Q9CE43_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:14:49 2002","Thu Mar 14 17:43:06 2002","Thu Mar 14 17:43:06 2002","Thu Mar 14 17:43:06 2002","","Thu Mar 14 17:43:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1475 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:14:49 2002","","No significant hits to the NCBI PDB database.","SMU.1621c","","Residues 1 to 69 (E-value = 2.3e-42) place SMu1475 in the DUF1250 family which is described as Protein of unknown function (DUF1250) (PF06855)","Thu Mar 14 17:43:06 2002","24380001","","","","","","1","","","SMU.1621c","955" "SMu1476","1549205","1548696","510","ATGGAACGTGCGATTTTTGCAGGTGGCTGTTTTTGGTGTATGGTACAGCCTTTTGAAGAACAAGATGGTATTTTGTCTGTCCGATCAGGCTATACAGGAGGACATGTGGTTAATCCGACTTATGAACAAGTTTGCTCAAAAATGACTGGACATACGGAAGCTGTCGAAATTATCTTTGATGAAAGCAAGATTTCTTATGCAGACCTTGTCGAAATCTATTGGCGGCAGACCGATCCAACCGATTCTTTTGGACAATTTGAAGATCGTGGGGATAACTATCGTCCTGTTATCTTTTATTTTGATGAGCAACAGCGGAAAATAGCAGAGCAGTCCAAGGCTAATTTGCAGGCTTCAGGTCATTTTAACAGACCGATCGTGACTACGATTGAAGCAGCGCAGCCATTTTACGAAGCAGAAAAAGACCATCAGGCTTTCTATCGGAAAAATCCTGAACGCTATGCGAGAAGCTCTGCTATTCGCCATCACTTTTTAAAGGAGAACTGGTCATGA","5.40","-5.69","19663","MERAIFAGGCFWCMVQPFEEQDGILSVRSGYTGGHVVNPTYEQVCSKMTGHTEAVEIIFDESKISYADLVEIYWRQTDPTDSFGQFEDRGDNYRPVIFYFDEQQRKIAEQSKANLQASGHFNRPIVTTIEAAQPFYEAEKDHQAFYRKNPERYARSSAIRHHFLKENWS","1548712","","peptide methionine sulfoxide reductase A","Cytoplasm","Several matches in gapped BLAST to peptide methionine sulfoxide reductase: residues 1-169 are 79% similar to the enzyme in S.pyogenes (gi15674584). Residues 2-168 are 73% similar to the protein from Lactococcus lactis (gi15673988).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1510 (1e-76).","

InterPro
IPR002569
Domain

Methionine sulfoxide reductase A
PD003489	$\"[1-153]T$	PMSR
G3DSA:3.30.1060.10	$\"[1-155]T$	MsrA
PF01625	$\"[2-159]T$	PMSR
TIGR00401	$\"[2-158]T$	msrA
SSF55068	$\"[1-154]T$	MsrA

noIPR
unintegrated

unintegrated
PTHR10173	$\"[1-158]T$	PTHR10173

","BeTs to 9 clades of COG0225COG name: Peptide methionine sulfoxide reductaseFunctional Class: OThe phylogenetic pattern of COG0225 is --t-y--Cebrhujgp-l---Number of proteins in this genome belonging to this COG is 1","***** IPB002569 (Peptide methionine sulfoxide reductase) with a combined E-value of 2.2e-35. IPB002569A 6-15 IPB002569B 65-98 IPB002569C 125-154","Residues 2-154 are 74% similar to a (REDUCTASE PEPTIDE METHIONINE SULFOXIDE) protein domain (PD003489) which is seen in Q9CE42_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 17:49:16 2002","Fri Aug 18 12:01:56 2006","Fri Aug 18 12:01:56 2006","Thu Mar 14 17:48:09 2002","Thu Mar 14 17:48:09 2002","Thu Mar 14 17:48:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1476 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 17:49:16 2002","Fri Aug 18 12:01:56 2006","pdb1FF3A Chain A, Structure Of The Peptide Methionine Sulfoxi... 130 1e-031pdb1FVGA Chain A, Crystal Structure Of Bovine Peptide Methion... 115 5e-027pdb1FVAA Chain A, Crystal Structure Of Bovine Methionine Sulf... 114 7e-027","SMU.1622c","","Residues 2 to 159 (E-value = 3.6e-78) place SMu1476 in the PMSR family which is described as Peptide methionine sulfoxide reductase (PF01625)","Thu Mar 14 17:48:09 2002","","","","","","","1","","","SMU.1622c","703" "SMu1477","1550134","1549274","861","ATGAATTCATTGCTTGCAACAGTCATCACTGGGATGGTGACAGATGAAAATGCTAATTCCTATTTTATCCAGAAGGATGGTCTAACCTTTGCTTTGGATAAAAAAGAAGGTCAGCACAAGATTGGTGATATGATCAAGGGCTTTGTCTATACAGACATTCATCAAAAAGCACGCTTGACAACTGCTAATATAGAAACAACACGTACCACATATGGTTGGGGTACAGTAGCTGGGGTGCGACGGGATCTGGGTGTTTTTCTTGATGTTGGCTTGCCAGATAAGCAGTTTGTTGTTTCTTTGGATGTTTTGCCAGAATTAAAAGAATTGTGGCCCAAAAAAGGGGATAAACTTTATGTTCATCTAGAAATTGATAAGAAAGATCGTATTTGGGCTATTCCAGCTGAACCAGACGTTTTTCAAAAATTAGCTGGACCAGCCTATGATAATATGCAAAATCAGACTTGGCCTGCTATTGTTTACCGTCTTAAGTTGACAGGAACTTTTGTTTATCTACCAGAAAATAATATGCTGGGTTTCATTCATCCAAGTGAACGCTATGCCGAACCACGCTTGGGTCAAGTTGTTAATGCGCGTGTTATTGGTTTTCGTAAGGTAGATCGGACACTCAATTTATCCTTAAAACCGCGTTCCTTTGAAATGCTGGAAAATGATGCGCAGATGATTTTGACTTATTTAGAAAACAATGGTGGGTTTATGACACTCAATGATAAGTCAACCCCTGCTGATATCAAAGCAACTTTTGGGATTTCTAAAGGTCAATTTAAAAAAGCCTTGGGAGGCTTAATGAAAGCTAGGAAAGTGAAACAAGATATTAACGGAACAGAATTGATTGACAACTAA","9.80","4.97","32219","MNSLLATVITGMVTDENANSYFIQKDGLTFALDKKEGQHKIGDMIKGFVYTDIHQKARLTTANIETTRTTYGWGTVAGVRRDLGVFLDVGLPDKQFVVSLDVLPELKELWPKKGDKLYVHLEIDKKDRIWAIPAEPDVFQKLAGPAYDNMQNQTWPAIVYRLKLTGTFVYLPENNMLGFIHPSERYAEPRLGQVVNARVIGFRKVDRTLNLSLKPRSFEMLENDAQMILTYLENNGGFMTLNDKSTPADIKATFGISKGQFKKALGGLMKARKVKQDINGTELIDN","1549290","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins: residues 1-284 are 78% similar to S.pyogenes (gi|15674583|) and 76% similar to S.pneumoniae (gi|15902891|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1511 (1e-137).","

InterPro
IPR003029
Domain

RNA binding S1
SM00316	$\"[149-214]T$	S1
PS50126	$\"[152-214]T$	S1

InterPro
IPR014464
Family

Predicted nucleic acid binding protein, YitL type
PIRSF012524	$\"[2-286]T$	YitL_S1

noIPR
unintegrated

unintegrated
SSF50249	$\"[147-216]T$	Nucleic_acid_OB

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-283 are 60% similar to a (PROTEOME COMPLETE PA1116 YUIC) protein domain (PD128620) which is seen in Q9CE41_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:14:21 2002","Thu Mar 14 17:53:47 2002","Thu Mar 14 17:53:47 2002","Thu Mar 14 17:53:47 2002","","Thu Mar 14 17:53:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1477 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 17:53:47 2002","","No significant hits to the NCBI PDB database.","SMU.1623c","","No significant hits to the Pfam 11.0 database","Thu Mar 14 17:53:47 2002","24380003","","","","","","1","","","SMU.1623c","429" "SMu1478","1550936","1550379","558","ATGGCAAATGCTATTGTAGAAAAAGCAAAAGAAAGATTTGAACAATCACACCAGTCCCTCGCGCGTGAATTCGGCAGTATTCGTGCTGGCCGTGCCAATGCAAGTCTTTTAGATCGGATTGAAGTAGAATATTATGGTGTACCAACTCCTCTCAATCAACTAGCTTCAATCACTGTTCCAGAAGCACGCGTTCTTTTGGTTTCACCATTTGATAAATCATCATTAAAAGATATTGAACATGCTATCAATGCTTCTGATATTGGGATTAATCCGGCTAATGACGGTTCTGTTATTCGTTTGGTTATTCCAGCCTTGACTGAAGAAACGCGCAAAGAGCTGGCTAAGGAAGTAAAAAAAGTTGGTGAAAATGCGAAGGTTGCTATTCGTAATATTCGTCGTGATGCCATGGATGAAGCTAAAAAGCAGGAAAAGATTAAAGAAATCACAGAAGATGAATTGAAATCTCTTGAGAAAGATATTCAAAAAGTTACAGATGAAGCTGTTAAGCATATTGATAGCATGACGGCAAATAAAGAAAAGGAACTTCTTGAAGTTTAA","5.60","-3.26","20627","MANAIVEKAKERFEQSHQSLAREFGSIRAGRANASLLDRIEVEYYGVPTPLNQLASITVPEARVLLVSPFDKSSLKDIEHAINASDIGINPANDGSVIRLVIPALTEETRKELAKEVKKVGENAKVAIRNIRRDAMDEAKKQEKIKEITEDELKSLEKDIQKVTDEAVKHIDSMTANKEKELLEV","1550395","","ribosome recycling factor","Cytoplasm","Several matches in gapped BLAST to ribosome recycling factor: residues 1-185 are 88% similar to the protein in S.pyogenes (gi15900824) and are 87% similar to the protein from S.pneumoniae (gi15902890).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1512 (2e-88).","

InterPro
IPR002661
Family

Ribosome recycling factor
PD004103	$\"[9-184]T$	RRF
PTHR20982:SF3	$\"[1-185]T$	RRF
PF01765	$\"[19-183]T$	RRF
TIGR00496	$\"[10-185]T$	frr

noIPR
unintegrated

unintegrated
G3DSA:1.10.132.20	$\"[66-185]T$	G3DSA:1.10.132.20
PTHR20982	$\"[1-185]T$	PTHR20982
SSF55194	$\"[1-185]T$	SSF55194

","BeTs to 13 clades of COG0233COG name: Ribosome recycling factorFunctional Class: JThe phylogenetic pattern of COG0233 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002661 (Ribosome recycling factor) with a combined E-value of 2.4e-58. IPB002661A 27-63 IPB002661B 78-130","Residues 22-185 are 86% similar to a (RIBOSOME FACTOR RECYCLING RELEASING) protein domain (PD004103) which is seen in RRF_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 17:56:47 2002","Thu Mar 14 17:56:25 2002","Thu Aug 31 11:05:08 2006","Thu Mar 14 17:56:25 2002","Thu Mar 14 17:56:25 2002","Thu Mar 14 17:56:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1478 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 17:56:47 2002","Thu Aug 31 11:05:08 2006","pdb1DD5A Chain A, Crystal Structure Of Thermotoga Maritima Ri... 177 8e-046pdb1EH1A Chain A, Ribosome Recycling Factor From Thermus Ther... 163 1e-041","SMU.1624c","","Residues 19 to 183 (E-value = 3.5e-90) place SMu1478 in the RRF family which is described as Ribosome recycling factor (PF01765)","Thu Mar 14 17:56:25 2002","","","","Rolland,N., Janosi,L., Block,M.A., Shuda,M., Teyssier,E., Miege,C.,Cheniclet,C., Carde,J.P., Kaji,A. and Joyard,J.Plant ribosome recycling factor homologue is a chloroplasticprotein and is bactericidal in escherichia coli carryingtemperature-sensitive ribosome recycling factorProc. Natl. Acad. Sci. U.S.A. 96 (10), 5464-5469 (1999)PubMed: 10318906","","Thu Mar 14 17:58:53 2002","1","","","SMU.1624c","587" "SMu1479","1552024","1551287","738","ATGGTAAAACCTAAATATAGTCGTGTATTGATTAAGCTCTCTGGTGAGGCTTTAGCTGGCGAAAAAGGAGTTGGTATTGACATTCCAACTGTTCAAACTATTGCTCAGGAGATCAAGGAAGTTCATGACTCAGGCATTGAAATTGCTCTTGTTATCGGTGGTGGAAATCTTTGGAGAGGCGAGCCTGCTTCTAAGGCAGGTATGGATCGTGTTCAGGCTGATTATACTGGGATGCTGGGGACAGTTATGAATGCTCTTGTTATGGCAGACGCTCTCCAGCATGCAGGAGTAGACACGCGTGTTCAGACAGCAATTGCCATGCAGCAAGTTGCAGAGCCATATATTCGCGGACGGGCACTGCGTCACCTTCAAAAGGGTCGTATTGTTATCTTTGCTGCAGGTGTTGGTTCCCCTTACTTCTCAACCGATACAACATCTGCTCTTCGCGCAGCGGAAATTGAAGCAGATGCTATTTTGATGGCCAAAAATGGCGTTGACGGCGTTTATAATGATGATCCTCGTAAAAATGCTGATGCTATCAAATTTAATGAGTTAACCCATATGGAAGTTCTCAAACGCGGACTGAAGATTATGGATTCAACGGCCAGCTCACTGTCAATGGACAATGACATTGACTTAGTTGTTTTCAATCTGAATGAATCAGGAAACATCAAACGTGTTATCTTTGGCGAACAAATTGGGACAACTGTAACCAGCAGAATTTCTGATTCAGAATAA","5.40","-4.03","26317","MVKPKYSRVLIKLSGEALAGEKGVGIDIPTVQTIAQEIKEVHDSGIEIALVIGGGNLWRGEPASKAGMDRVQADYTGMLGTVMNALVMADALQHAGVDTRVQTAIAMQQVAEPYIRGRALRHLQKGRIVIFAAGVGSPYFSTDTTSALRAAEIEADAILMAKNGVDGVYNDDPRKNADAIKFNELTHMEVLKRGLKIMDSTASSLSMDNDIDLVVFNLNESGNIKRVIFGEQIGTTVTSRISDSE","1551303","For other 'pyr' genes see SMu0542 (pyrD); SMu0087 (pyrG); SMu0780 (pyrR);SMu0781 (pyrP); SMu0782 (pyrB); SMu0783 (pyrA); SMu1109 (pyrC); SMu1116 (pyrE); SMu1117 (pyrF); SMu1118 (pyrD) and SMu1119 (pyrDII),(pyrZ).","uridylate kinase (UMP-kinase)","Cytoplasm","Several matches in gapped BLAST to uridylate kinase: residues 1-245 are 82% similar to the enzyme in S.pneumoniae gi15902889. Residues 2-243 are 82% similar to the protein from S.pyogenes (gi15674581).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1513 (1e-115).","

InterPro
IPR001048
Domain

Aspartate/glutamate/uridylate kinase
G3DSA:3.40.1160.10	$\"[3-237]T$	Aa_kinase
PF00696	$\"[7-217]T$	AA_kinase
SSF53633	$\"[6-239]T$	Aa_kinase

InterPro
IPR011817
Family

Uridylate kinase
PIRSF005650	$\"[7-239]T$	Uridylate_kin
TIGR02075	$\"[6-238]T$	pyrH_bact

","BeTs to 16 clades of COG0528COG name: Uridylate kinaseFunctional Class: FThe phylogenetic pattern of COG0528 is amtk-qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 142-191 are 80% similar to a (KINASE TRANSFERASE URIDYLATE BIOSYNTHESIS PROTEOME) protein domain (PD102733) which is seen in Q9CE38_LACLA.Residues 20-141 are 63% similar to a (KINASE URIDYLATE TRANSFERASE 2.7.4.-) protein domain (PD005760) which is seen in Q9CE38_LACLA.Residues 193-237 are 71% similar to a (KINASE URIDYLATE TRANSFERASE 2.7.4.-) protein domain (PD406533) which is seen in Q9CE38_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 14:43:25 2006","Thu Mar 14 18:01:58 2002","Thu Sep 14 14:43:25 2006","Thu Mar 14 18:01:58 2002","","Thu Mar 14 18:01:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1479 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 18:04:12 2002","","No significant hits to the NCBI PDB database.","SMU.1625c","","Residues 7 to 217 (E-value = 3.9e-58) place SMu1479 in the AA_kinase family which is described as Amino acid kinase family (PF00696)","Thu Mar 14 18:01:58 2002","","","","Yamanaka,K., Ogura,T., Niki,H. and Hiraga,S.Identification and characterization of the smbA gene, a suppressorof the mukB null mutant of Escherichia coliJ. Bacteriol. 174 (23), 7517-7526 (1992)PubMed: 1447125","","Thu Mar 14 18:04:12 2002","1","","","SMU.1625c","430" "SMu1480","1552887","1552198","690","ATGGCTAAAAAAAGCAAACAATTACGTGCTGCTCTTGAAAAAATCGACAGTACAAAAGCGTACAGTGTAGAAGAAGCTGTAGCACTTGCAAAAGAAACTAATTTCGCAAAATTTGATGCAACTGTAGAAGTTGCTTACAACCTTAACATTGATGTTAAAAAAGCTGACCAACAAATCCGTGGTGCCATGGTATTGCCAAATGGTACTGGTAAAACGCAACGTGTTCTTGTTTTTGCCCGCGGCGCTAAAGCTGAAGAAGCTAAAGAAGCTGGCGCAGACTTCGTTGGTGAAGATGATCTTGTTCAAAAAATTAACGGCGGTTGGCTAGATTTTGATGTTGTTATTGCAACACCTGATATGATGGCAATCGTTGGTCGCCTTGGACGTGTTCTTGGTCCGCGTAACCTCATGCCAAATCCTAAAACGGGAACAGTAACTATGGATGTTGCCAAGGCAGTCGAAGAATCTAAAGGCGGTAAAATCACTTACCGTGCCGACAAAGCTGGTAATGTACAGACTATCATCGGTAAAGTATCATTTGATGCAGATAAACTAGTTGAAAACTTCAAAGCTTTCAATGACGTTATTGCTAAAGCAAAACCTGCTACTGCAAAAGGTACTTACATAACAAACCTTGTACTGACAACTACTCAAGGTCCTGGTATCAAGGTTGATGCAAATTCATTTTAA","10.00","5.00","24496","MAKKSKQLRAALEKIDSTKAYSVEEAVALAKETNFAKFDATVEVAYNLNIDVKKADQQIRGAMVLPNGTGKTQRVLVFARGAKAEEAKEAGADFVGEDDLVQKINGGWLDFDVVIATPDMMAIVGRLGRVLGPRNLMPNPKTGTVTMDVAKAVEESKGGKITYRADKAGNVQTIIGKVSFDADKLVENFKAFNDVIAKAKPATAKGTYITNLVLTTTQGPGIKVDANSF","1552214","For other 'rpl' genes see SMu0639 (rplT); SMu0771 (rplU); SMu0152 (rplM); SMu1941 (rplI); SMu0869 (rplJ); SMu0872 (rpl); SMu1175 (rplS) and SMu1481 (rplK).","50S ribosomal protein L1","Cytoplasm, Periplasm","Several matches in gapped BLAST to 50S ribosomal protein L1: residues 1-228 are 87% similar to the protein in S.pneumoniae (gi|15900538|) and are 86% similar to the protein from S.pyogenes (gi|15674580|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1519 (1e-109).","

InterPro
IPR002143
Family

Ribosomal protein L1
PD001314	$\"[14-228]T$	Ribosomal_L1
PF00687	$\"[15-221]T$	Ribosomal_L1
PS01199	$\"[120-139]T$	RIBOSOMAL_L1

InterPro
IPR005878
Family

Ribosomal protein L1, bacterial and chloroplast form
PTHR23105:SF5	$\"[21-225]T$	Ribosom_L1_bac
TIGR01169	$\"[3-229]T$	rplA_bact

noIPR
unintegrated

unintegrated
G3DSA:3.30.190.20	$\"[2-228]T$	G3DSA:3.30.190.20
PTHR23105	$\"[21-225]T$	PTHR23105
SSF56808	$\"[6-228]T$	SSF56808

","BeTs to 17 clades of COG0081COG name: Ribosomal protein L1Functional Class: JThe phylogenetic pattern of COG0081 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002143 (Ribosomal protein L1) with a combined E-value of 1.1e-77. IPB002143A 51-100 IPB002143B 111-121 IPB002143C 127-140 IPB002143D 157-201 IPB002143E 208-224","Residues 22-224 are 80% similar to a (RIBOSOMAL 50S RRNA-BINDING L1P) protein domain (PD001314) which is seen in Q9CE47_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 09:18:16 2002","Thu Mar 14 18:06:45 2002","Thu Oct 17 09:18:16 2002","Thu Mar 14 18:06:45 2002","Thu Mar 14 18:06:45 2002","Thu Mar 14 18:06:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1480 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 18:08:03 2002","Thu Mar 14 18:06:45 2002","pdb|1EG0|N Chain N, Fitting Of Components With Known Structure ... 217 1e-057pdb|1AD2| Ribosomal Protein L1 Mutant With Serine 179 Replac... 213 1e-056pdb|487D|H Chain H, Seven Ribosomal Proteins Fitted To A Cryo-E... 212 4e-056","SMU.1626c","","Residues 15 to 221 (E-value = 2.2e-114) place SMu1480 in the Ribosomal_L1 family which is described as Ribosomal protein L1p/L10e family (PF00687)","Thu Mar 14 18:06:45 2002","","","","Kimura,M., Kimura,J. and Ashman,K.The complete primary structure of ribosomal proteins L1, L14, L15,L23, L24 and L29 from Bacillus stearothermophilusEur. J. Biochem. 150 (3), 491-497 (1985)PubMed: 4018095","","Thu Mar 14 18:08:03 2002","1","","","SMU.1626c","431" "SMu1481","1553410","1552985","426","ATGGCTAAAAAAGTCGAAAACATCGTAAAACTTCAAATTCCTGCTGGTAAAGCAACACCAGCTCCGCCAGTTGGACCAGCACTTGGTCAAGCAGGAATCAACATCATGGGATTCACCAAAGAATTCAATGCTCGTACAGCTGATCAAGCTGGTATGATTATCCCAGTTGTTATCTCAGTTTATGAAGATAAATCATTTGATTTCGTCACAAAAACACCGCCAGCTGCTGTTCTTTTGAAAAAAGCTGCAGGTGTTGACAAGGGTTCTGGTGAACCAAACAAAACTAAAGTTGCTTCAGTAACGCGTGCACAAGTACAAGAAATCGCTGAAACAAAAATGCCAGATTTGAACGCTGCAAACCTTGAGTCTGCAATGCGTATGATCGAAGGTACTGCTCGTTCTATGGGATTCACTGTTACTGACTAA","10.00","2.99","14800","MAKKVENIVKLQIPAGKATPAPPVGPALGQAGINIMGFTKEFNARTADQAGMIIPVVISVYEDKSFDFVTKTPPAAVLLKKAAGVDKGSGEPNKTKVASVTRAQVQEIAETKMPDLNAANLESAMRMIEGTARSMGFTVTD","1553001","For other 'rpl' genes see SMu0639 (rplT); SMu0771 (rplU); SMu0152 (rplM); SMu1941 (rplI); SMu0869 (rplJ); SMu0872 (rpl); SMu1175 (rplS) and SMu1480 (rplA).","50S ribosomal protein L11","Periplasm, Membrane","Several matches in gapped BLAST to 50S ribosomal protein L11: residues 1-141 are 93% similar to the protein in S.pyogenes (gi|15674579|) and are 94% similar to the protein from S.pneumoniae (gi|15900537|). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1520 (7e-74).","

InterPro
IPR000911
Family

Ribosomal protein L11
PD001367	$\"[9-72]T$	Ribosomal_L11
G3DSA:1.10.10.250	$\"[72-141]T$	Ribosomal_L11
PIRSF002179	$\"[7-141]T$	RplL11_L12
PTHR11661	$\"[1-139]T$	Ribosomal_L11
PF00298	$\"[71-139]T$	Ribosomal_L11
PF03946	$\"[8-66]T$	Ribosomal_L11_N
SM00649	$\"[9-140]T$	RL11
PS00359	$\"[126-141]T$	RIBOSOMAL_L11
SSF46906	$\"[66-141]T$	Ribosomal_L11
SSF54747	$\"[8-70]T$	Ribosomal_L11

InterPro
IPR006519
Family

Ribosomal protein L11, bacterial
PTHR11661:SF1	$\"[1-139]T$	Ribosom_L11_bac
TIGR01632	$\"[3-141]T$	L11_bact

noIPR
unintegrated

unintegrated
G3DSA:3.30.1550.10	$\"[2-71]T$	G3DSA:3.30.1550.10
PIRSF500072	$\"[1-141]T$	Rpl11

","BeTs to 17 clades of COG0080COG name: Ribosomal protein L11Functional Class: JThe phylogenetic pattern of COG0080 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000911 (Ribosomal protein L11) with a combined E-value of 7.6e-73. IPB000911A 9-41 IPB000911B 54-92 IPB000911C 107-140 IPB000911A 13-45 IPB000911A 16-48","Residues 73-139 are 83% similar to a (RIBOSOMAL 50S RNA-BINDING PROTEOME COMPLETE 60S L11P) protein domain (PD082503) which is seen in Q9CE46_LACLA.Residues 9-72 are 93% similar to a (RIBOSOMAL 50S RNA-BINDING PROTEOME) protein domain (PD001367) which is seen in Q9CE46_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 09:17:19 2002","Thu Mar 14 18:10:46 2002","Thu Oct 17 09:17:19 2002","Thu Mar 14 18:10:46 2002","Thu Mar 14 18:10:46 2002","Thu Mar 14 18:10:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1481 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 14 18:11:20 2002","Thu Mar 14 18:10:46 2002","pdb|1MMS|A Chain A, Crystal Structure Of The Ribosomal Protein ... 204 4e-054pdb|1EG0|K Chain K, Fitting Of Components With Known Structure ... 204 5e-054pdb|487D|L Chain L, Seven Ribosomal Proteins Fitted To A Cryo-E... 197 5e-052","SMU.1627c","","Residues 8 to 66 (E-value = 7.7e-35) place SMu1481 in the Ribosomal_L11_N family which is described as Ribosomal protein L11, N-terminal domain (PF03946)Residues 71 to 139 (E-value = 3.9e-42) place SMu1481 in the Ribosomal_L11 family which is described as Ribosomal protein L11, RNA binding domain (PF00298)","Thu Mar 14 18:10:46 2002","","","","Kimura,M., Kimura,J. and Ashman,K. The complete primary structure of ribosomal proteins L1, L14, L15, L23, L24 and L29 from Bacillus stearothermophilus Eur. J. Biochem. 150 (3), 491-497 (1985) PubMed: 4018095 ","","Thu Mar 14 18:11:20 2002","1","","","SMU.1627c","704" "SMu1482","1553598","1553951","354","ATGACTATGTATAAATTAATGGCAATAGCCTTCATTTTTTTAACGTTAATCTTTTCTTATATTATCGTTTCAACTTTTCATTTGAGACGCTTTGGTATTAATCTAGCAGACATTGCTTTGCCGCTTTTTGCAGTAGAAATTGTCTTAGTATCAGCAAAGTTTTATACTCACAGCTTTCTGCCGCATTATTTGCTGGCCATGTCCATTCTTTCTCTAACCTTAGCTATCCGTCAGATCAGAAAAAGAAAGACCTTTTCTTTCAGACGGTTCTTTAAATTCTTTTGGAGGTCAGGCTTCATTTTGACTTTCTTCTTTTATTTGGCGACTGTCATTGCTGCCTTTCTTGCCAGCTGA","11.70","11.70","13757","MTMYKLMAIAFIFLTLIFSYIIVSTFHLRRFGINLADIALPLFAVEIVLVSAKFYTHSFLPHYLLAMSILSLTLAIRQIRKRKTFSFRRFFKFFWRSGFILTFFFYLATVIAAFLAS","1553961","","conserved hypothetical protein","Membrane, Cytoplasm","Limited matches in gapped BLAST to hypothetical proteins: residues 1-114 are 38% similar to S.pyogenes (gi|15674578|) and residues 1-115 are 31% similar to S.pneumoniae (gi|15902612|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1525 (5e-15).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-19]?$	signal-peptide
tmhmm	$\"[4-22]?$ $\"[32-52]?$ $\"[58-76]?$ $\"[97-115]?$	transmembrane_regions

InterPro
IPR002543
Domain

Cell divisionFtsK/SpoIIIE
PF01580	$\"[396-592]T$	FtsK_SpoIIIE
PS50901	$\"[421-618]T$	FTSK

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[431-613]T$	AAA

noIPR
unintegrated

unintegrated
PTHR22683	$\"[181-720]T$	SPORULATION PROTEIN RELATED
PTHR22683:SF1	$\"[181-720]T$	DNA TRANSLOCASE FTSK
signalp	$\"[1-43]?$	signal-peptide
tmhmm	$\"[2-20]?$ $\"[26-48]?$ $\"[60-80]?$ $\"[109-129]?$ $\"[134-154]?$	transmembrane_regions

InterPro
IPR002130
Domain

Peptidyl-prolyl cis-trans isomerase, cyclophilin-type
PR00153	$\"[79-94]T$ $\"[105-117]T$ $\"[156-171]T$	CSAPPISMRASE
G3DSA:2.40.100.10	$\"[66-249]T$	PPIase_cyclophilin
PF00160	$\"[65-249]T$	Pro_isomerase
PS00170	$\"[100-117]T$	CSA_PPIASE_1
PS50072	$\"[73-248]T$	CSA_PPIASE_2
SSF50891	$\"[66-250]T$	CSA_PPIase

noIPR
unintegrated

unintegrated
PTHR11071	$\"[66-179]T$ $\"[204-251]T$	PTHR11071
PS51257	$\"[1-18]T$	PROKAR_LIPOPROTEIN

","BeTs to 8 clades of COG0652COG name: Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin familyFunctional Class: OThe phylogenetic pattern of COG0652 is --t-Y--CEbRhuj---l---Number of proteins in this genome belonging to this COG is 1","***** IPB002130 (Cyclophilin-type peptidyl-prolyl cis-trans isomerase) with a combined E-value of 1.9e-28. IPB002130A 73-94 IPB002130B 100-138 IPB002130C 158-195","Residues 68-109 are 64% similar to a (ISOMERASE ROTAMASE CIS-TRANS PEPTIDYL-PROLYL CYCLOPHILIN) protein domain (PD002184) which is seen in O74942_SCHPO.Residues 70-242 are 27% similar to a (ISOMERASE PEPTIDYL-PROLYL CIS-TRANS) protein domain (PD071504) which is seen in PPIB_MYCTU.Residues 145-238 are 37% similar to a (ISOMERASE ROTAMASE PEPTIDYL-PROLYL) protein domain (PD199519) which is seen in PPIA_ACICA.Residues 143-235 are 55% similar to a (ISOMERASE PROTEOME PEPTIDYL-PROLYL) protein domain (PD397838) which is seen in Q9CIJ2_LACLA.Residues 143-241 are 49% similar to a (ISOMERASE ROTAMASE CYCLOPHILIN CIS-TRANS PEPTIDYL-PROLYL) protein domain (PD000341) which is seen in Q9CH46_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 18:26:45 2002","Fri Aug 18 12:22:13 2006","Fri Aug 18 12:22:13 2006","Thu Mar 14 18:25:50 2002","Thu Mar 14 18:25:50 2002","Thu Mar 14 18:25:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1484 is paralogously related (blast p-value < 1e-3) to SMu0442, a predicted conserved hypothetical protein/possible hydrolase.","Thu Mar 14 18:26:45 2002","Fri Aug 18 12:22:13 2006","pdb1CLH Cyclophilin (Nmr, 12 Structures) 83 4e-017pdb2NUL Peptidylprolyl Isomerase From E. Coli 82 1e-016pdb1LOPA Chain A, Cyclophilin A Complexed With Succinyl-Ala-P... 79 5e-016","SMU.1631","","Residues 65 to 249 (E-value = 4.1e-46) place SMu1484 in the Pro_isomerase family which is described as Cyclophilin type peptidyl-prolyl cis-trans isomerase (PF00160)","Thu Mar 14 18:25:50 2002","24380010","","","","","","1","","","SMU.1631","705" "SMu1485","1558065","1557370","696","ATGAAAATTGGAATTATTGCAGCTATGGAGGAAGAATTAAAACTCCTCTTAGCGGAATTAAATCATAAAAGAGAAGAAATCTGTTTAGAACGACCTTACTACAGCGGTAAACTAGGTAAACATCAGGTCGTTCTGGTGCAAAGCGGTGTTGGCAAAGTCATGTCTGCTATGAGTGTGGCTGTTTTAGTAGATCATTTTAAAGTTGATGCTTTGATTAATACAGGTTCAGCAGGAGCTTTAGCGCCAGATTTGGCTATTGGTGATGTTGTAGTGGCAGATAGACTCGCTTATCATGATGTAGATTTAACTGCCCTTGGTTATGAATTTGGACGTATGTCAGGGCAGCCTCTTTTCTTTAAATCAGACCAAACCTTTGTGAGCGCTTTTGAAGAGGTGTTGGCTAAGCACCATATTCATAGTAAAATCGGTCTCATTACAACCAGTGATTCCTTTATGGCTGGTAAGGAAAAAACGATTTTTGTTAAGGAACATTTTCCAGAAGTGCAGGCAGTTGAGATGGAAGGCGCAGCGATTGCTCAAGCAGCTTATGCAGCCAAACGCCCTTTTGTCGTTATTCGATCAATCAGTGATACAGCAGCTCATGATGCCAATATTACTTTTGAAGAATTTGTTGTTAAGGCTGGAAAACAATCGGCTCAAGTCCTCTTAAAATTTTTGGAAATCTTAGACCAATGA","6.10","-4.87","25203","MKIGIIAAMEEELKLLLAELNHKREEICLERPYYSGKLGKHQVVLVQSGVGKVMSAMSVAVLVDHFKVDALINTGSAGALAPDLAIGDVVVADRLAYHDVDLTALGYEFGRMSGQPLFFKSDQTFVSAFEEVLAKHHIHSKIGLITTSDSFMAGKEKTIFVKEHFPEVQAVEMEGAAIAQAAYAAKRPFVVIRSISDTAAHDANITFEEFVVKAGKQSAQVLLKFLEILDQ","1557386","","MTA/SAH nucleosidase","Cytoplasm","Several matches in gapped BLAST to MTA/SAH nucleosidase: residues 1-229 are 54% similar to the enzyme in S.pyogenes (gi15674570). Residues 1-230 are 53% similar to the protein from S.pneumoniae (gi15902938).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1535 (5e-76).","

InterPro
IPR000845
Family

Nucleoside phosphorylase
PF01048	$\"[2-226]T$	PNP_UDP_1

InterPro
IPR010049
Family

MTA/SAH nucleosidase
TIGR01704	$\"[2-229]T$	MTA/SAH-Nsdase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1580	$\"[1-229]T$	G3DSA:3.40.50.1580
PTHR21234	$\"[1-231]T$	PTHR21234
PTHR21234:SF6	$\"[1-231]T$	PTHR21234:SF6
SSF53167	$\"[1-230]T$	SSF53167

","BeTs to 9 clades of COG0775COG name: Nucleoside phosphorylaseFunctional Class: FThe phylogenetic pattern of COG0775 is ------vcEbRhuj--OliN-Number of proteins in this genome belonging to this COG is 1","***** IPB000845 (Purine and other phosphorylases, family 1) with a combined E-value of 3.1e-07. IPB000845B 29-63 IPB000845C 142-152 IPB000845D 167-203","Residues 33-112 are 70% similar to a (PHOSPHORYLASE NUCLEOSIDASE COMPLETE PROTEOME) protein domain (PD003928) which is seen in Q9CEG1_LACLA.Residues 161-211 are 52% similar to a (NUCLEOSIDASE HYDROLASE ENZYME) protein domain (PD005987) which is seen in Q9CEG1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 14 18:30:57 2002","Thu Mar 14 18:30:34 2002","Thu Aug 31 12:32:26 2006","Thu Mar 14 18:30:34 2002","Thu Mar 14 18:30:34 2002","Thu Mar 14 18:30:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1485 is paralogously related (blast p-value < 1e-3) to SMu1122, a predicted purine-nucleotide phosphorylase.","Thu Mar 14 18:30:57 2002","","No significant hits to the NCBI PDB database.","SMU.1632c","","Residues 2 to 226 (E-value = 7.2e-61) place SMu1485 in the PNP_UDP_1 family which is described as Phosphorylase family (PF01048)","Thu Mar 14 18:30:34 2002","","","","Cornell,K.A. and Riscoe,M.K.Cloning and expression of Escherichia coli5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase:identification of the pfs gene productBiochim. Biophys. Acta 1396 (1), 8-14 (1998)PubMed: 9524204","","Thu Aug 31 12:32:26 2006","1","","","SMU.1632c","589" "SMu1486","1558399","1558076","324","ATGGGAAAGCCCCTGTTAACAGATGAAATGATTGCTCGAGCCAATCGTGGCGAGAAGTTCTATGATAAGGGTCATTTTGACTCAGAAGAGACCATTGTCATTTCAACAGATAATCAGATACCTCAATCAAGTTATGATGAAACGCGTGATTTGAATGAAAACTATGACGATTATGATTATGAAGACTATGATGAAGAACCTATTATCAAAAGTCGCCGCATTGAAAATGCGAAACGTGGTAAATTTCAGTCTAAATTAAATTGGATTTTAATAGGAGTCATTCTTCTTTTAGCCTTTTTAGCTTATGCAATCTTTAAACTATAA","4.50","-6.76","12558","MGKPLLTDEMIARANRGEKFYDKGHFDSEETIVISTDNQIPQSSYDETRDLNENYDDYDYEDYDEEPIIKSRRIENAKRGKFQSKLNWILIGVILLLAFLAYAIFKL","1558092","","conserved hypothetical protein","Cytoplasm, Membrane","Limited matches in gapped BLAST to hypothetical protein. Residues 1-93 are 44% similar to gi|15675708 of S.pneumoniae and 40% similar to gi|15674569| of S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1536 (1e-12).","

InterPro
IPR013256
Family

Chromatin SPT2
SM00784	$\"[3-84]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[86-104]?$	transmembrane_regions

InterPro
IPR000086
Domain

NUDIX hydrolase
G3DSA:3.90.79.10	$\"[2-179]T$	NUDIX_hydrolase
PF00293	$\"[42-174]T$	NUDIX

InterPro
IPR015797
Domain

NUDIX
SSF55811	$\"[4-180]T$	NUDIX_hydrolase

noIPR
unintegrated

unintegrated
PTHR11839	$\"[5-179]T$	PTHR11839
PTHR11839:SF1	$\"[5-179]T$	PTHR11839:SF1

","BeTs to 6 clades of COG0494COG name: NTP pyrophosphohydrolases (MutT family) including oxidative damage repair enzymesFunctional Class: L,RThe phylogenetic pattern of COG0494 is a-T-YqvCEBRHuj---linxNumber of proteins in this genome belonging to this COG is 6","No significant hits to the Blocks database.","Residues 116-178 are 39% similar to a (PROTEOME COMPLETE ADP-RIBOSE) protein domain (PD063277) which is seen in Q9CEF9_LACLA.Residues 5-83 are 51% similar to a (COMPLETE PROTEOME HYDROLASE ADP-RIBOSE) protein domain (PD359927) which is seen in Q9CEF9_LACLA.Residues 39-84 are 63% similar to a (COMPLETE PROTEOME HYDROLASE MUTATOR MUTT/NUDIX FAMILY) protein domain (PD000653) which is seen in Q9KCP5_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:09:52 2002","Fri Aug 18 12:29:40 2006","Fri Aug 18 12:29:40 2006","Thu Mar 14 18:38:34 2002","","Thu Mar 14 18:38:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1487 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:09:52 2002","","No significant hits to the NCBI PDB database.","SMU.1634c","","Residues 42 to 174 (E-value = 2.3e-17) place SMu1487 in the NUDIX family which is described as NUDIX domain (PF00293)","Thu Mar 14 18:38:34 2002","24380013","","","","","","1","","","SMU.1634c","706" "SMu1488","1560351","1558972","1380","ATGACGAACTATGCTATTATCCTTGCTGCTGGTAAGGGTACTCGAATGAAATCGGATTTACCAAAAGTTTTGCACCAAGTGGCAGGACTTACTATGTTGGAACATGTTAAACGTGCTGTTGATACCATGAATCCAGCAAAAACAGTGACCGTTGTCGGTCATAAAGCAGAACTTGTTCAAAAGGTTCTAGAAGACCAATCAGAATTTGTCCTCCAATCGGAGCAATTGGGAACGGGGCATGCCGTTATGATGGCTGAGTCATCTTTGGCTGAGCTTGAAGGACAAACGCTTGTCATTGCTGGTGACACGCCTTTGATTAGAGGAGAAAGCCTGAAAAACTTGCTGCATTATCATAAAAGCCATAAAAATGTAGCGACAATCTTAACTGCTGAAGCAGATGATCCTTTCGGTTATGGTCGTATTATTCGCAATCAAAATGCCGAAGTAATCAAGATTGTTGAACAAAAGGATGCTTCTGATTATGAACAACAAGTCAAAGAAATTAACACGGGAACGTATGTTTTCGACAATAAGCGCCTTTTTGAAGCCTTAAAAGAAATCAATACCAATAATGCTCAGGGTGAATATTATTTGACAGATGTTATCAGTATTTTTAAAGAGGCAGATGAGAAGGTTGGTGCTTATAAACTAGCTGATTTTGACGAGAGTCTGGGAGTTAATGATCGTGTTGCTTTAGCAAAAGCAGAAAAAGTTATGCGTCGTCGCATTAATCATGCGCATATGGTCAACGGTGTGACTTTGACAAACCCAGCTAGTACCTATATTGACAGTGATGTTATCATTGCGCCAGATGTAGTTATTGAGGCTAATGTGACTCTTAAAGGTCAGACCAAAATTGAAACAGGAGCTGTTTTGACTAATGGTACCTATATTGTTGATTCAGTTATTGGTGAAAATACTGTAATTACCCATTCAATGATTGAAGCTTCTCGGATTGAAAAAAATGTTACAGTTGGGCCTTATGCACACTTACGACCAAATTCAGTCTTAGAAGAAGCGGTCCATGTGGGGAATTTTGTGGAAGTTAAGGCTTCGACACTTGGTAAAGAGACCAAAGCAGGGCATCTGACCTATATTGGCAATGCTGAGGTTGGTCATGATGTTAATTTTGGTGCTGGTACCATTACAGTCAATTATGATGGACAAAATAAATATAAGACAATTATAGGCAACCATGTTTTTGTTGGCAGCAATTCTACCATCATTGCTCCTTTAACTATTGGTGATAATGCTTTGACAGCAGCAGGTTCAACGATTCATAAAGATGTCCCAGTTGATAGTATTGCTATCGGTCGCGGCCGTCAAGTCAATAAAGAAGGCTATGCCAAGAAAAAACCGCATCATCCCAATAATAAATAG","6.70","-2.63","49884","MTNYAIILAAGKGTRMKSDLPKVLHQVAGLTMLEHVKRAVDTMNPAKTVTVVGHKAELVQKVLEDQSEFVLQSEQLGTGHAVMMAESSLAELEGQTLVIAGDTPLIRGESLKNLLHYHKSHKNVATILTAEADDPFGYGRIIRNQNAEVIKIVEQKDASDYEQQVKEINTGTYVFDNKRLFEALKEINTNNAQGEYYLTDVISIFKEADEKVGAYKLADFDESLGVNDRVALAKAEKVMRRRINHAHMVNGVTLTNPASTYIDSDVIIAPDVVIEANVTLKGQTKIETGAVLTNGTYIVDSVIGENTVITHSMIEASRIEKNVTVGPYAHLRPNSVLEEAVHVGNFVEVKASTLGKETKAGHLTYIGNAEVGHDVNFGAGTITVNYDGQNKYKTIIGNHVFVGSNSTIIAPLTIGDNALTAAGSTIHKDVPVDSIAIGRGRQVNKEGYAKKKPHHPNNK","1558988","For other 'glm' genes see SMu1086 (glmS) and SMu1301 (glmM). ","UDP-N-acetylglucosamine pyrophosphorylase","Cytoplasm, Extracellular","Matches in gapped BLAST to UDP-N-acetylglucosamine pyrophosphorylase sequences. Residues The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1538 (0.0).","

InterPro
IPR001228
Domain

4-diphosphocytidyl-2C-methyl-D-erythritol synthase
PF01128	$\"[4-55]T$	IspD

InterPro
IPR001451
Repeat

Bacterial transferase hexapeptide repeat
PF00132	$\"[265-282]T$ $\"[283-300]T$ $\"[316-333]T$ $\"[334-351]T$ $\"[368-385]T$ $\"[393-410]T$ $\"[411-428]T$	Hexapep

InterPro
IPR005882
Family

UDP-N-acetylglucosamine pyrophosphorylase
TIGR01173	$\"[3-454]T$	glmU

InterPro
IPR011004
Domain

Trimeric LpxA-like
SSF51161	$\"[252-459]T$	Trimer_LpxA_like

noIPR
unintegrated

unintegrated
G3DSA:2.160.10.10	$\"[252-440]T$	G3DSA:2.160.10.10
G3DSA:3.90.550.10	$\"[5-251]T$	G3DSA:3.90.550.10
PTHR22572	$\"[11-309]T$ $\"[326-452]T$	PTHR22572
PTHR22572:SF17	$\"[11-309]T$ $\"[326-452]T$	PTHR22572:SF17
SSF53448	$\"[1-253]T$	SSF53448

","BeTs to 8 clades of COG1207COG name: N-acetylglucosamine-1-phosphate uridyltransferase (GlmU); Contains nucleotidyltransferase and I-patch acetyltransferase domainsFunctional Class: MThe phylogenetic pattern of COG1207 is -----qvcebrhuj------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001451 (Bacterial transferase hexapeptide repeat) with a combined E-value of 2.1e-12. IPB001451 396-431 IPB001451 262-297 IPB001451 268-303 IPB001451 319-354 IPB001451 313-348 IPB001451 325-360***** IPB001228 (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) with a combined E-value of 2.8e-12. IPB001228A 5-37","Residues 291-343 are 49% similar to a (ADP-GLUCOSE TRANSFERASE PYROPHOSPHORYLASE) protein domain (PD000882) which is seen in Q9CEF8_LACLA.Residues 126-214 are 50% similar to a (UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE PROTEOME) protein domain (PD009670) which is seen in P96382_MYCTU.Residues 219-291 are 46% similar to a (UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE PROTEOME) protein domain (PD172814) which is seen in Q9RW61_DEIRA.Residues 1-114 are 59% similar to a (TRANSFERASE COMPLETE PROTEOME BIOSYNTHESIS) protein domain (PD000318) which is seen in Q9CEF8_LACLA.Residues 395-445 are 49% similar to a (TRANSFERASE ACETYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD013088) which is seen in Q9K6Y8_BACHD.Residues 344-386 are 81% similar to a (COMPLETE PROTEOME PYROPHOSPHORYLASE) protein domain (PD203566) which is seen in Q9CEF8_LACLA.Residues 365-442 are 61% similar to a (COMPLETE PROTEOME TRANSFERASE ACYLTRANSFERASE LIPID) protein domain (PD000343) which is seen in Q9KGJ6_BACHD.Residues 138-220 are 68% similar to a (TRANSFERASE PYROPHOSPHORYLASE ADP-GLUCOSE) protein domain (PD001252) which is seen in Q9CEF8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 08:20:20 2002","Mon Mar 11 16:45:07 2002","Thu Oct 17 09:12:18 2002","Mon Apr 1 16:44:15 2002","Tue Jan 15 16:38:17 2002","Tue Jan 15 16:38:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1488 is paralogously related (blast p-value < 1e-3) to SMu0285, tetrahydrodipicolinate succinylase, SMu1399, glucose-1-phosphate adenylyltransferase, and SMu1330, glucose-1-phosphate thymidyltransferase.","Mon Apr 1 16:44:15 2002","Tue Jan 15 16:38:17 2002","pdb|1FWY|A Chain A, Crystal Structure Of N-Acetylglucosamine 1-... 212 6e-056","SMU.1635c","","Residues 4 to 229 (E-value = 1.1e-10) place SMu1488 in the NTP_transferase family which is described as Nucleotidyl transferase (PF00483)","Tue Jan 15 16:38:17 2002","","","","","","","1","","","SMU.1635c","160" "SMu1489","1560974","1560390","585","ATGTTTCCCGAGGAAGCAGAAACGAAGAGGTCAAAAAATAAACCAGAAGATACAGTCTGTCAAGCGGATAGTAACAAGAAGTCAGACAGAAAATTGATGATAGGAGATAAAATGACCCCACAAGAACTATGGAATCAATACAAACGAGTCAACCCAAACATTGGTGATAGTATCGATGCCTGGCAATTTGGAGCAGAACCTGATCAACTGGCACAATTAGTCCTAAAAGGAGTTAAGACAGCGACTGCCTCTGCTTATGATCTGTATAAAGTTGACAATGAGCCGCTTCCGCAAAAAGACAGTTATGATGTGATTCTAGATAGTCAAAATCAAGCGATTTGTATTATTCAAATTATCAAGGTTTCTGTTGTACCTTTCAAAGAAGTTTCTGATGAACATGCTTTTAAGGAAGGAGAGGGCGATCGCTCCTTGACTTGGTGGCAGGATAGTCATCGAAAAATTTTTACCCAATGGTTTAAAGATGCTGCTTTAACATTCAAAGAAGATAGTCTGATTGTGCTTGAAGAGTTTCGCTGTGTCTATCCTCATTTAACAAATAAATCGAAAAATGCTATAATGGATTGA","5.10","-5.41","22318","MFPEEAETKRSKNKPEDTVCQADSNKKSDRKLMIGDKMTPQELWNQYKRVNPNIGDSIDAWQFGAEPDQLAQLVLKGVKTATASAYDLYKVDNEPLPQKDSYDVILDSQNQAICIIQIIKVSVVPFKEVSDEHAFKEGEGDRSLTWWQDSHRKIFTQWFKDAALTFKEDSLIVLEEFRCVYPHLTNKSKNAIMD","1560406","","conserved hypothetical protein","Periplasm, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 38-182 are 63% similar to residues 1-145 of gi|15902749| from S.pneumoniae. Residues 37-181 are 37% similar to residues 5-152 of gi|16802042| from L.innocua.SMu1489 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR009326
Family

Protein of unknown function DUF984
PF06171	$\"[60-181]T$	DUF984

noIPR
unintegrated

unintegrated
G3DSA:3.10.400.10	$\"[36-180]T$	G3DSA:3.10.400.10
SSF88697	$\"[36-183]T$	SSF88697

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 68-152 are 50% similar to a (PROTEOME YJFI COMPLETE) protein domain (PD175902) which is seen in Q9CH09_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:09:11 2002","Mon Mar 11 16:39:18 2002","Wed Oct 9 08:09:11 2002","Mon Mar 11 16:39:18 2002","","Mon Mar 11 16:39:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1489 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:09:11 2002","","No significant hits to the NCBI PDB database.","SMU.1636c","","Residues 60 to 181 (E-value = 3.6e-77) place SMu1489 in the DUF984 family which is described as Protein of unknown function (DUF984) (PF06171)","Mon Mar 11 16:39:18 2002","24380015","","","","","","1","","","SMU.1636c","" "SMu1490","1561282","1561076","207","ATGGATGCTTTGAATCATTTAATGATGACTAACCTGCTGACCAATTTGTTGTTTTTAATTGTGGGTTTAGGCTATGGTGTTACTTTTGTTTTGATGAAAGAAATTTTGGCTGGTCTGTCGTTCGGCCACAACGGCGCTTCTCTTTATGAATGGCAGTTGGTTGCTTCTAATCTTTACAGGAGTGATAGTTTACGAAGAAGTCTTTGA","7.70","0.46","7587","MDALNHLMMTNLLTNLLFLIVGLGYGVTFVLMKEILAGLSFGHNGASLYEWQLVASNLYRSDSLRRSL","1561092","","hypothetical protein","Extracellular","No significant hits in gapped BLAST.SMu1490 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-26]?$	signal-peptide
tmhmm	$\"[12-32]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:08:38 2002","Mon Mar 11 16:32:42 2002","Wed Oct 9 08:08:38 2002","Mon Mar 11 16:32:42 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1490 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:08:38 2002","","No significant hits to the NCBI PDB database.","SMU.1637c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 16:32:42 2002","24380016","","","","","","1","","","SMU.1637c","" "SMu1491","1561587","1561426","162","ATGCTATTAGTCGGAAGTTTAAATAGAGATATTAAAAAGAATTCAAAAGTCTTTTTTGAGCCTAAGCTTTTACATCTTCCAAGTGATAGAAATAGGTCTTGCTTCGAAGTTATGATTAGGATAACAAACGGGAAAAAAGGAAGAGCAGAAAATCATCTGTGA","11.00","6.41","6135","MLLVGSLNRDIKKNSKVFFEPKLLHLPSDRNRSCFEVMIRITNGKKGRAENHL","1561442","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu1491 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:08:16 2002","Mon Mar 11 16:28:22 2002","Wed Oct 9 08:08:16 2002","Mon Mar 11 16:28:22 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1491 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:08:16 2002","","No significant hits to the NCBI PDB database.","SMU.1638c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 16:28:22 2002","24380017","","","","","","1","","","SMU.1638c","" "SMu1492","1563631","1561622","2010","ATGACTGAAAAACAACCATTTTACATTACGACACCGATTTATTACCCGTCTGGGAAACTCCATATTGGCTCTGCCTATACAACCATTGCTTGTGATGTCTTGGCTCGCTATAAGCGTATGATGAATCATGACGTTTTTTATTTGACTGGACTTGATGAGCACGGTCAAAAGATTCAGCAAAAGTCTGAAGAAGCTGGTATCACACCGCAGGCGTATGTGGACGGTATGGCGGTTGGTGTTAAGGAATTGTGGAAGCTCCTTGACATCTCTTATGATAAGTTTATCCGCACGACAGATGATTACCATGAAAAAGTTGTGGCTGATGTTTTTGAAAAATTGCTAGCGCAGGGAGATATTTACTTGGGTGAATACTCAGGTTGGTATTCTGTTTCTGACGAGGAATTTTTCACTGAAAGCCAATTAGAGGAAATCTTCCGTGATGAAGACGGTAAAGTTATCGGTGGGATTGCACCATCAGGTCACGAAGTGGAATGGGTTTCAGAAGAATCCTATTTCCTCCGTCTCAGTAACTATGCTGATCGTCTAGTAGATTTTTTCCATGCTCATCCTGATTTTATCCAGCCAGATGGTCGTATGAATGAAATCATCAAGAACTTTATTGAGCCCGGTTTAGAAGATTTAGCAGTTTCGCGTACCTCATTTACTTGGGGCGTTAAAGTACCTTCAAATCCTAAGCACGTGGTTTACGTATGGATTGATGCCCTTCTCAACTATGCAACAGCTCTTGGTTACGGTCAAGATGCCCATGCCAACTTTGATAAATTCTGGAATGGTACAGTCTTCCACATGGTTGGCAAAGACATTCTGCGCTTCCACTCTATTTATTGGCCAATCCTGCTCATGATGCTTGATTTAAAGATGCCAGAACGTCTGATTGCTCATGGTTGGTTTGTCATGAAAGATGGTAAGATGTCCAAGTCTAAAGGAAATGTCGTTTACCCAGAAATGTTGGTTGAACGCTACGGACTTGATCCGCTTCGCTATTATCTCATGCGTAGTCTTCCAGTCGGTTCTGATGGCACTTTTACGCCAGAAGATTATGTTGGTCGTATCAACTATGAACTTGCCAATGACCTTGGTAATCTCCTCAACCGTACCGTTGCCATGATTAACAAGTATTTTGGTGGTGAGATTCCTGCTTATGTGGAAAATGTGACGGATTTTGATGCTGATTTGGCAGCAGTAGTTGCTGATAATTTGGCACAATACCACAAACAAATGAATGCTGTGGATTATCCACGCGCCCTTGAAACGGTTTGGAACATCATTTCGCGTACCAACAAGTACATTGACGAAACTACTCCTTGGGTATTGGCTAAGGATAAAGCTAAACGTGATGATTTAGCAGCGGTTATGGCACATTTGGCAGCCAGCCTGCGCGTGGTGGCTCACCTCATTCAGCCATTTATGATGACCACATCAAATGCCATCATGGAACAGCTTGGTTTGGCCGGTCAATTTGATTTAGAAGGTCTTGAACTTGCAGGACTTCCGACGGGTGTCAAAGTGATTGCCAAAGGCACGCCAATCTTCCCGCGTCTTGATATGGATGAAGAAATTGCTTACATCAAAGAACAAATGGGTGACAACTCTGCGATTGCCCAAGAGGAAGAAAAAGAATGGAACCCAACAACAGTTGAGCTCAAAAACGAGAAGAAGGCTATTAAATTTGACGATTTTGACAAGTTGGAAATCCGTGTGGCTGAGGTCAAGGAAGTGTCTAAAGTGAAGGGTTCTGACAAGCTTCTTAAGTTCCGCTTGGACGCAGGGGATGGCGAAGATCGCCAAATTCTGTCTGGCATCGCCAAATATTATCCAAATGAGCTAGACTTGGTTGGTAAAAAACTCCAAATTGTTGCCAACCTTAAACCACGTAAGATGATGGGCTTGGTCAGTCAAGGTATGATTCTTTCAGCTGAACATGCTGATGGGAAACTTACCGTATTGACGGTAGATTCTTCAGTACCGAATGGTAGTCAGATTGGGTAA","4.90","-24.11","75629","MTEKQPFYITTPIYYPSGKLHIGSAYTTIACDVLARYKRMMNHDVFYLTGLDEHGQKIQQKSEEAGITPQAYVDGMAVGVKELWKLLDISYDKFIRTTDDYHEKVVADVFEKLLAQGDIYLGEYSGWYSVSDEEFFTESQLEEIFRDEDGKVIGGIAPSGHEVEWVSEESYFLRLSNYADRLVDFFHAHPDFIQPDGRMNEIIKNFIEPGLEDLAVSRTSFTWGVKVPSNPKHVVYVWIDALLNYATALGYGQDAHANFDKFWNGTVFHMVGKDILRFHSIYWPILLMMLDLKMPERLIAHGWFVMKDGKMSKSKGNVVYPEMLVERYGLDPLRYYLMRSLPVGSDGTFTPEDYVGRINYELANDLGNLLNRTVAMINKYFGGEIPAYVENVTDFDADLAAVVADNLAQYHKQMNAVDYPRALETVWNIISRTNKYIDETTPWVLAKDKAKRDDLAAVMAHLAASLRVVAHLIQPFMMTTSNAIMEQLGLAGQFDLEGLELAGLPTGVKVIAKGTPIFPRLDMDEEIAYIKEQMGDNSAIAQEEEKEWNPTTVELKNEKKAIKFDDFDKLEIRVAEVKEVSKVKGSDKLLKFRLDAGDGEDRQILSGIAKYYPNELDLVGKKLQIVANLKPRKMMGLVSQGMILSAEHADGKLTVLTVDSSVPNGSQIG","1561638","For other 'met' genes see SMu0796 (metE),(metC);SMu1527 (metB); SMu1335 (metA) and SMu1430 (metK).","methionyl-tRNA synthetase","Cytoplasm","Several matches in gapped BLAST to met-tRNA synthetases. Residues 1-669 are 80% similar to gi15902740 from S.pneumoniae. Residues 4-669 are 80% similar to gi15674551 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1557 (0.0).","

InterPro
IPR002304
Domain

Methionyl-tRNA synthetase, class Ia
TIGR00398	$\"[7-522]T$	metG

InterPro
IPR002547
Domain

t-RNA-binding region
PF01588	$\"[572-667]T$	tRNA_bind
PS50886	$\"[566-669]T$	TRBD

InterPro
IPR004495
Domain

Methionyl-tRNA synthetase, beta subunit, C-terminal
TIGR00399	$\"[524-669]T$	metG_C_term

InterPro
IPR008224
Family

Methionyl-tRNA synthetase, dimer-forming
PIRSF001528	$\"[5-669]T$	MetRS_dimerising

InterPro
IPR009080
Domain

Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
SSF47323	$\"[362-521]T$	tRNAsyn_1a_bind

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[565-668]T$	OB_NA_bd_sub

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[3-365]T$	Rossmann-like_a/b/a_fold

InterPro
IPR014758
Domain

Methionyl-tRNA synthetase, class Ia, N-terminal
PR01041	$\"[9-22]T$ $\"[41-55]T$ $\"[89-100]T$ $\"[235-246]T$ $\"[269-284]T$ $\"[361-372]T$	TRNASYNTHMET

InterPro
IPR015413
Domain

tRNA synthetase class I (M)
PF09334	$\"[7-374]T$	tRNA-synt_1g

noIPR
unintegrated

unintegrated
G3DSA:1.10.730.10	$\"[366-491]T$	G3DSA:1.10.730.10
PTHR11946	$\"[11-549]T$	PTHR11946
PTHR11946:SF1	$\"[11-549]T$	PTHR11946:SF1
PS51257	$\"[1-31]T$	PROKAR_LIPOPROTEIN
SSF50249	$\"[562-668]T$	Nucleic_acid_OB
SSF52374	$\"[3-365]T$	SSF52374

","BeTs to 17 clades of COG0143COG name: Methionyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0143 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002547 (Putative tRNA binding domain) with a combined E-value of 3.6e-12. IPB002547A 236-250 IPB002547B 628-645 IPB002547A 583-597***** IPB001412 (Aminoacyl-transfer RNA synthetases class-I) with a combined E-value of 4.7e-06. IPB001412A 14-24 IPB001412B 307-317","Residues 159-235 are 67% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000647) which is seen in SYM_BACSU.Residues 159-237 are 69% similar to a (SYNTHETASE LIGASE METHIONYL-TRNA) protein domain (PD380116) which is seen in Q9CHE0_LACLA.Residues 7-64 are 84% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000389) which is seen in Q9CHE0_LACLA.Residues 355-387 are 78% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA METRS) protein domain (PD261770) which is seen in Q9CHE0_LACLA.Residues 67-128 are 61% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD002670) which is seen in SYM_BACST.Residues 295-412 are 62% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000476) which is seen in SYM_BACSU.Residues 68-141 are 74% similar to a (SYNTHETASE LIGASE METHIONYL-TRNA) protein domain (PD222057) which is seen in Q9CHE0_LACLA.Residues 238-294 are 59% similar to a (SYNTHETASE LIGASE METHIONYL-TRNA) protein domain (PD210990) which is seen in Q9KGK8_BACHD.Residues 422-518 are 48% similar to a (SYNTHETASE LIGASE METHIONYL-TRNA) protein domain (PD013784) which is seen in Q9CHE0_LACLA.Residues 357-390 are 70% similar to a (SYNTHETASE AMINOACYL-TRNA COMPLETE) protein domain (PD349270) which is seen in Q9RUF3_DEIRA.Residues 431-535 are 47% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD008558) which is seen in Q9KGK8_BACHD.Residues 168-221 are 53% similar to a (SYNTHETASE LIGASE METHIONYL-TRNA) protein domain (PD389474) which is seen in Q9CD55_MYCLE.Residues 564-669 are 75% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD002123) which is seen in Q9CHE0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 15 09:17:06 2006","Mon Mar 11 15:54:15 2002","Tue Aug 15 09:17:06 2006","Mon Apr 1 16:42:52 2002","Mon Mar 11 15:54:15 2002","Mon Mar 11 15:54:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1492 is paralogously related (blast p-value < 1e-3) to SMu1766, a leucyl-tRNA synthetase, SMu1611, a valyl-tRNA synthetase, SMu0508, a isoleucine-tRNA synthetase, and SMu0141, cysteinyl-tRNA synthetase.","Mon Apr 1 16:42:52 2002","Tue Aug 15 09:17:06 2006","pdb1A8H Methionyl-Trna Synthetase From Thermus Thermophilus 330 4e-091pdb1QQTA Chain A, Methionyl-Trna Synthetase From Escherichia ... 169 9e-043","SMU.1639c","","Residues 3 to 350 (E-value = 2.6e-08) place SMu1492 in the tRNA-synt_1 family which is described as tRNA synthetases class I (I, L, M and V) (PF00133)Residues 572 to 667 (E-value = 2e-39) place SMu1492 in the tRNA_bind family which is described as Putative tRNA binding domain (PF01588)","Tue Aug 15 09:17:06 2006","","","","","","","1","","","SMU.1639c","161" "SMu1493","1564409","1564209","201","ATGGGTCTGGAAGAAAAGTTAAATCAAGCTAAAGGTGCTATTAAACAAGGTGCTGGTAAGCTCACTTCAGATAAAAAGGTCGAGACTGAAGGTGCTATTGAAAAAACAGTTGCTAAAGCAAAAGACAGCATCAAAGATATCAAGGACGGTGTAGAAGGTGCTGCTGAAGGTATTAAAAGTACTTTTTCTAACAAAGAATAA","9.10","0.99","6903","MGLEEKLNQAKGAIKQGAGKLTSDKKVETEGAIEKTVAKAKDSIKDIKDGVEGAAEGIKSTFSNKE","1564225","","conserved hypothetical protein","Cytoplasm, Periplasm","Limited weak matches in gapped BLAST to conserved hypothetical proteins. Residues 1-65 are 49% similar to gi|15901376 from S.pneumoniae. Residues 3-59 are 42% similar to gi|15675792 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0619 (8e-10).","

InterPro
IPR008462
Family

CsbD-like
PF05532	$\"[1-53]T$	CsbD

noIPR
unintegrated

unintegrated
SSF69047	$\"[1-66]T$	SSF69047

InterPro
IPR007353
Family

Protein of unknown function DUF421
PF04239	$\"[87-197]T$	DUF421

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-96 are 51% similar to a (PROTEOME COMPLETE YVIA) protein domain (PD393382) which is seen in Q9CDV2_LACLA.Residues 151-210 are 46% similar to a (PROTEOME COMPLETE YVIA) protein domain (PD386542) which is seen in Q9CDV2_LACLA.Residues 98-148 are 49% similar to a (PROTEOME COMPLETE YDFR TRANSMEMBRANE) protein domain (PD011350) which is seen in Q9CDV2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:07:26 2002","Mon Mar 11 15:47:45 2002","Wed Oct 9 08:07:26 2002","Mon Mar 11 15:47:45 2002","","Mon Mar 11 15:47:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1494 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:07:26 2002","","No significant hits to the NCBI PDB database.","SMU.1642c","","Residues 87 to 197 (E-value = 6.3e-41) place SMu1494 in the DUF421 family which is described as Protein of unknown function (DUF421) (PF04239)","Mon Mar 11 15:47:45 2002","24380020","","","","","","1","","","SMU.1642c","" "SMu1495","1565564","1565187","378","ATGACATTTTATTCATATAATTATGTTTTAAGTCGAATTAATCAACAAAACTGGATAACTGTAACGATTTCAGCTTTACTGCTTCTCGTAACAGGCCTTTTTGCCTTTAAAGCTTATCGCAACAAACGGGATACAAAATTCCGTGAATTGGTAATTATCTCTATACTGTCGTTGTTTGCGGTAATTTTAATAGGCATTAGTACCTTTCAAACCAATCAAGCTTCCAACAATCAATTTCAAACTTCTCTTCATTTTATCGAAGTGATTTCGAAAGATCTGGGAGTTGACAAATCAGAGGTCTATGTTAATACTTCGGCAGCAACGGACGGGACGATCGTAAAGGTCGGGAAGAATTTACCGAGCCATGAGTGGCAGTAA","10.20","3.46","14152","MTFYSYNYVLSRINQQNWITVTISALLLLVTGLFAFKAYRNKRDTKFRELVIISILSLFAVILIGISTFQTNQASNNQFQTSLHFIEVISKDLGVDKSEVYVNTSAATDGTIVKVGKNLPSHEWQ","1565203","","conserved hypothetical protein","Membrane, Cytoplasm","Limited weak hits in gapped BLAST to conserved hypothetical proteins. Residues 1-60 are 61% similar to gi|15901673 from S.pneumoniae. Residues 1-115 are 29% similar to gi|15674092 from L.lactis.SMu1495 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[16-36]?$ $\"[51-69]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-115 are 29% similar to a (PROTEOME COMPLETE) protein domain (PD397873) which is seen in Q9CDV1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:07:02 2002","Mon Mar 11 15:39:25 2002","Wed Oct 9 08:07:02 2002","Mon Mar 11 15:39:25 2002","","Mon Mar 11 15:39:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1495 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:07:02 2002","","No significant hits to the NCBI PDB database.","SMU.1643c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 15:39:25 2002","24380021","","","","","","1","","","SMU.1643c","" "SMu1496","1566742","1565939","804","ATGAATCAAAACGAGTGGTTAAATCAATTTCGTTCTGTAAATGGTCGTGAACCAAGTCAAGAAGAGCTTCAGGCAGCTTTTCAAAGAGGAGAATTCAGCCAAACAGTTCCGGCAGCAAAGAGAAAAATGAAGACCTCTACCATTGTTATCATTAGTGTAATAAGTATTCTTGCTGCTTTATTGTTGATTGCAGGCGGAGGCACTGTTTACTACTATGTTTCTGGGAATGCAGATGGTGTTTGGGAAAATACGTACTCTTACTATTATAGTTCTAAGAAACATCGTTGGGTTAGTGCAACTAGAGAAAATAAGCAAAATAATTTTGAAGATGAGACATTCTTAGATATTAAAAAGAATTCGGTAAAAACTTATAGTTACTATGTTGCCAAAAATTCTGAAGACTTTACTTCAACTAGCAGTTATAGCCATATCCGATCAATGTATAAGACAAATATTTGGCAAAGAAAATTTGATCTGAGTATTACACAAGCTGAATATATGAAAGACATCAGGAAATACATCAATAACTTTTTCAAAACACAGTACACCTCTGACCAAGATTTGAAAGAGCTGCAAGATAATTATAAAAAGACCTATAAAGAAATTAAAAAAGGAAAAGTAACTTATCAAAGAAAGGGGAAGCAACTAATCGTTAAAACTTACAATAAAAAAGGTAGATTAATAGAACAAGATGTTTATATTAAACGAACAGGAAAAGCAGTGACGAAGTTATATCACAATTATCGTAAAGCAGAAAAAGCTGAACGTGCACGGTTAGATAAATTAAATGCAATGTCTTACTAA","10.60","21.72","31466","MNQNEWLNQFRSVNGREPSQEELQAAFQRGEFSQTVPAAKRKMKTSTIVIISVISILAALLLIAGGGTVYYYVSGNADGVWENTYSYYYSSKKHRWVSATRENKQNNFEDETFLDIKKNSVKTYSYYVAKNSEDFTSTSSYSHIRSMYKTNIWQRKFDLSITQAEYMKDIRKYINNFFKTQYTSDQDLKELQDNYKKTYKEIKKGKVTYQRKGKQLIVKTYNKKGRLIEQDVYIKRTGKAVTKLYHNYRKAEKAERARLDKLNAMSY","1565955","","conserved hypothetical protein","Extracellular, Membrane","Similar to Str0450.SMu1496 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[50-72]?$	transmembrane_regions

InterPro
IPR004537
Family

Tellurite resistance methyltransferase, TehB-1
PF03848	$\"[96-288]T$	TehB
TIGR00477	$\"[54-291]T$	tehB

InterPro
IPR014431
Family

Tellurite resistance methyltransferase, TehB type-2
PIRSF005215	$\"[2-293]T$	TehB

InterPro
IPR015392
Domain

Protein of unknown function DUF1971
PF09313	$\"[14-95]T$	DUF1971

noIPR
unintegrated

unintegrated
PD331793	$\"[8-100]T$	PD331793
G3DSA:3.40.50.150	$\"[108-227]T$	G3DSA:3.40.50.150
PTHR10108	$\"[116-207]T$	PTHR10108
PTHR10108:SF25	$\"[116-207]T$	PTHR10108:SF25
SSF53335	$\"[103-291]T$	SSF53335

","BeTs to 6 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 108-161 are 57% similar to a (RESISTANCE TEHB HEMAGGLUTININ COMPLETE) protein domain (PD404028) which is seen in Q9CMZ4_PASMU.Residues 10-107 are 45% similar to a (RESISTANCE PROTEOME COMPLETE TEHB) protein domain (PD036581) which is seen in TEHB_HAEIN.Residues 170-223 are 64% similar to a (HEMAGGLUTININ RESISTANCE TEHB COMPLETE) protein domain (PD402867) which is seen in TEHB_HAEIN.Residues 224-291 are 72% similar to a (RESISTANCE TELLURITE PROTEOME COMPLETE) protein domain (PD186997) which is seen in Q9X3Q7_STRPN.Residues 108-203 are 48% similar to a (PROTEOME COMPLETE RESISTANCE TELLURITE) protein domain (PD022815) which is seen in O85201_STRPN.Residues 17-99 are 37% similar to a (HEMAGGLUTININ VACB GAPA-RND TELLURITE) protein domain (PD331793) which is seen in Q9X3Q7_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 09:09:44 2002","Thu Aug 31 12:34:34 2006","Thu Aug 31 12:34:34 2006","Thu Oct 17 09:09:44 2002","","Mon Mar 11 15:32:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1497 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 09:09:44 2002","","No significant hits to the NCBI PDB database.","SMU.1645","","Residues 96 to 288 (E-value = 9.4e-115) place SMu1497 in the TehB family which is described as Tellurite resistance protein TehB (PF03848)","Mon Mar 11 15:32:05 2002","24380023","","","Liu M, Taylor DE.Characterization of gram-positive tellurite resistance encoded by the Streptococcus pneumoniae tehB gene.FEMS Microbiol Lett. 1999 May 15;174(2):385-92.PMID: 10339832","","Mon Mar 11 15:32:05 2002","1","","","SMU.1645","590" "SMu1498","1568529","1567891","639","ATGAAGATTGATAAAAAATTATTAGTGTTGACAAGTTTGATTATTCTGCTGCCTGTCTTGTTAGGTTGTTTCTTTTGGTCACAGCTGCCAAAAACGATAGCGACGCATTTTGATCTATCAGGTCAAGCTAATGGCTTTAGTAGTCGTTTGTTTGCTGTTTTTGGACTTCCGTTTTTTCTCTTGTTGCTTCATTGGTTTTGTCTCTTTATGACCAGCAAGGATCCAAAAGCCAATAATGTTAGCTCTAAAATGCATCGTCTGATTTATTGGATTATTCCTTTGGTATCTTGTTTTGTGATGATTTCGATTTATGGACAGGCTTTTGGCTATTTGAGTAATCATGTTCTGATAGCTAATCTTCTTATAGGAATCCTGTTGATTACTATTGGTAATTATATGCCAAAAACCCGTCGTAATTACACCATAGGCATTCGTCTGCCATGGACTTTGGATAATGATGAAAATTGGAACAAAACTCATCGATTGGCTGGTAAACTTTGGGTTAGCGGGGGTGTCCTTATTTTCATCAATGCTTTTGTTCAAATCGTCGTTTTGCAGGTGTTTGTCATAGTTTTGGCAGTTATGATTGTACTGCCCATTCTTTATTCATTTATTCTAAATCAGAAGAAAAAAGTATAG","10.80","14.03","24173","MKIDKKLLVLTSLIILLPVLLGCFFWSQLPKTIATHFDLSGQANGFSSRLFAVFGLPFFLLLLHWFCLFMTSKDPKANNVSSKMHRLIYWIIPLVSCFVMISIYGQAFGYLSNHVLIANLLIGILLITIGNYMPKTRRNYTIGIRLPWTLDNDENWNKTHRLAGKLWVSGGVLIFINAFVQIVVLQVFVIVLAVMIVLPILYSFILNQKKKV","1567907","","conserved hypothetical protein (possible hemolysis inducing protein)","Membrane, Cytoplasm","Single significant hit in gapped BLAST to gi|2239172, defined as heamolysis inducing protein in S. iniae. Rsidues 1-206 are 36% similar to this protein.SMu1498 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR012867
Family

Protein of unknown function DUF1648
PF07853	$\"[13-58]T$	DUF1648

noIPR
unintegrated

unintegrated
PS51257	$\"[1-23]T$	PROKAR_LIPOPROTEIN

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 22-206 are 38% similar to a (PROTEOME YVAZ COMPLETE ORF1) protein domain (PD037212) which is seen in O33653_STRIN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 15:13:39 2002","Fri Jan 3 15:48:33 2003","Fri Jan 3 15:48:33 2003","Mon Mar 11 15:11:40 2002","","Mon Mar 11 15:11:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1498 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 15:13:39 2002","","No significant hits to the NCBI PDB database.","SMU.1646c","","No significant hits to the Pfam 11.0 database","Mon Mar 11 15:11:40 2002","24380024","","","","","Wed Oct 9 08:05:43 2002","1","","","SMU.1646c","" "SMu1499","1568797","1568519","279","ATGGGATTTGCTGAAACGTTTAAGGCTTTGTCAAATCCAATTCGACGCGATATTCTAGATTTACTAAAGTTGGGGCAATTATCAGCTGGTGAAATTTCTAGTCATTTTGAACTAGCGGGAGCTACTATTTCGCACCATCTTAGTGTCTTGAAAAAAGCAGATTTGGTACGAGAAACACGAGAGAAGAATTTTATTTACTATGAACTCAATACCTCGGTTTTGGAGGATATGATGGTCTGGTTGGCTGATTTGAAAGGAAATACGCATGATGAAGATTGA","5.20","-4.05","10403","MGFAETFKALSNPIRRDILDLLKLGQLSAGEISSHFELAGATISHHLSVLKKADLVRETREKNFIYYELNTSVLEDMMVWLADLKGNTHDED","1568535","","transcriptional regulator","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Residues 7-81 are 52% similar to gi|16080432 from B.subtilis. Residues 7-84 are 39% similar to gi|16127258 from C.crescentus.SMu1499 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001845
Domain

Bacterial regulatory protein, ArsR
PR00778	$\"[7-22]T$ $\"[39-54]T$ $\"[54-69]T$	HTHARSR
PF01022	$\"[12-58]T$	HTH_5
SM00418	$\"[5-83]T$	HTH_ARSR
PS50987	$\"[1-89]T$	HTH_ARSR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[3-87]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[3-89]T$	SSF46785

","BeTs to 10 clades of COG0640COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0640 is AMTK-qVCEBR----------Number of proteins in this genome belonging to this COG is 2","***** IPB001845 (Bacterial regulatory proteins, ArsR family) with a combined E-value of 1.7e-22. IPB001845A 7-22 IPB001845B 25-69","Residues 7-67 are 52% similar to a (DNA-BINDING TRANSCRIPTION REGULATION) protein domain (PD001992) which is seen in O32242_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 15:07:18 2002","Mon Mar 11 15:03:11 2002","Thu Oct 17 09:07:21 2002","Thu Oct 17 09:07:21 2002","Mon Mar 11 15:03:11 2002","Mon Mar 11 15:03:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1499 is paralogously related (blast p-value < 1e-3) to SMu1913, a predicted transcriptional regulator.","Mon Mar 11 15:07:18 2002","","No significant hits to the NCBI PDB database.","SMU.1647c","","Residues 7 to 84 (E-value = 8.5e-20) place SMu1499 in the HTH_5 family which is described as Bacterial regulatory protein, arsR family (PF01022)","Mon Mar 11 15:03:11 2002","24380025","","","","","","1","","","SMU.1647c","" "SMu1500","1569161","1568916","246","ATGGTGAGACTTCTATTGCATATCATTTTATTAGTTTTCTTTATTTGGTACCTCATCAGAATTCTTCGTTTTTGGGGCAAGCAGTCGGCAGATGAACCTTTGTGGGTACCTAAAAAAATTGGTGTGGGAATTAGTTTAAATCCAAGGAATACGCTTGGTTTTTGGATAAGTCTGCTTGTGATACTATCTGTGCTTATTATCCTTATTGTCTTGATAATATTTTACTTTCTGGTAGAAGGTGAGTGA","10.70","3.22","9489","MVRLLLHIILLVFFIWYLIRILRFWGKQSADEPLWVPKKIGVGISLNPRNTLGFWISLLVILSVLIILIVLIIFYFLVEGE","1568932","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu1500 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-80]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[56-78]?$	transmembrane_regions

InterPro
IPR000097
Family

AP endonuclease, family 1
TIGR00195	$\"[1-273]T$	exoDNase_III
PS00726	$\"[37-46]?$	AP_NUCLEASE_F1_1
PS00728	$\"[234-245]T$	AP_NUCLEASE_F1_3

InterPro
IPR004808
Family

Exodeoxyribonuclease III xth
PTHR22748	$\"[67-275]T$	ExoIII_xth
TIGR00633	$\"[1-274]T$	xth

InterPro
IPR005135
Domain

Endonuclease/exonuclease/phosphatase
PF03372	$\"[1-273]T$	Exo_endo_phos

noIPR
unintegrated

unintegrated
G3DSA:3.60.10.10	$\"[1-275]T$	G3DSA:3.60.10.10
SSF56219	$\"[1-275]T$	SSF56219

","BeTs to 10 clades of COG0708COG name: Exonuclease IIIFunctional Class: LThe phylogenetic pattern of COG0708 is a-t-y--cebrhuj--ol--XNumber of proteins in this genome belonging to this COG is 1","***** IPB000097 (AP endonucleases family 1) with a combined E-value of 3.7e-49. IPB000097A 1-13 IPB000097B 37-46 IPB000097C 107-144 IPB000097D 160-194 IPB000097E 221-268","Residues 40-275 are 80% similar to a (ENDONUCLEASE EXODEOXYRIBONUCLEASE) protein domain (PD002469) which is seen in EXOA_STRPN.Residues 1-39 are 79% similar to a (EXODEOXYRIBONUCLEASE EXONUCLEASE) protein domain (PD231805) which is seen in EXOA_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 1 11:52:54 2002","Tue Jul 5 12:20:01 2005","Tue Jul 5 12:20:48 2005","Mon Oct 21 15:51:50 2002","Fri Feb 1 11:48:22 2002","Fri Feb 1 11:48:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1501 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 1 11:52:54 2002","Tue Jul 5 12:19:29 2005","pdb1DEWB Chain B, Crystal Structure Of Human Ape1 Bound To Ab... 164 1e-041pdb1DE8A Chain A, Human ApurinicAPYRIMIDINIC ENDONUCLEASE-1 (... 164 1e-041pdb1BIX The Crystal Structure Of The Human Dna Repair Endo... 164 1e-041","SMU.1649","","Residues 1 to 273 (E-value = 6.6e-38) place SMu1501 in the Exo_endo_phos family which is described as Endonuclease/Exonuclease/phosphatase family (PF03372)","Fri Feb 1 11:48:22 2002","24380027","","Faustoferri RC, Hahn K, Weiss K, Quivey RG.Smx nuclease is the major, low-pH-inducible apurinic/apyrimidinic endonuclease in Streptococcus mutans.J Bacteriol. 2005 Apr;187(8):2705-14.PMID: 15805517","Shida T, Ogawa T, Ogasawara N, Sekiguchi J.Characterization of Bacillus subtilis ExoA protein: a multifunctional DNA-repair enzyme similar to the Escherichia coli exonuclease III.Biosci Biotechnol Biochem. 1999 Sep;63(9):1528-34.PMID: 10540738","Tue Jul 5 12:20:01 2005","Fri Feb 1 12:00:54 2002","1","","","SMU.1649","432" "SMu1502","1570909","1570286","624","ATGGTTTTATCAAAAAAACATGCTCGTAAAGTATTAGAAGAAATTATTGCGCTTTATCCAGATGCTGTTCCTAGCTTAAATTTTAAAAATCATTTTGAGTTGTTAATTGCTGTTATTTTATCAGCTCAGACAACAGATGCAGCAGTTAATAAAGTGACTCCTGCCTTATTTGCAGCTTATCCGAGACCAAAAGATCTAGCTAAGGCTGACTTGAAAGATCTTGAATCTTATATTTCTCAGATTGGACTCTATCGGAATAAGGCGAAATTCTTAAAAGGATGTTCGCAACAGTTAGTCGAGCATTATAATGGTCAAATACCTCAAACGAGAAAAGAACTAGAAAGCTTGTCTGGTGTCGGTCGCAAGACAGCTAATGTTGTCATGAGTGTCGGCTTTGGTCTTCCTGCCTTTGCGGTAGACACCCATGTCAGCCGTATTTGTAAGCATCACAATATTGTGAAACAAACAGCAAGTCCTTTAGAAGTGGAAAAGCGTGTAACAGAAGTACTCCCGCCAGAAGAATGGCTGCCAGCCCACCAAGCACTCATTTATTTTGGGCGGGAAGTTTGCCATCCAAAAAATCCTGAATGTCAAAAGTATCCGCAATTGTATGAATTCGATTGA","8.80","5.73","23276","MVLSKKHARKVLEEIIALYPDAVPSLNFKNHFELLIAVILSAQTTDAAVNKVTPALFAAYPRPKDLAKADLKDLESYISQIGLYRNKAKFLKGCSQQLVEHYNGQIPQTRKELESLSGVGRKTANVVMSVGFGLPAFAVDTHVSRICKHHNIVKQTASPLEVEKRVTEVLPPEEWLPAHQALIYFGREVCHPKNPECQKYPQLYEFD","1570302","For other 'end' genes see SMu1384 (endA).","endonuclease III (DNA repair)","Cytoplasm, Extracellular","Significant hits in gapped BLAST to endonuclease III proteins. Residues 1-206 are 74% similar to >gi|15901139 from Streptococcus pneumoniae. Residues 2-204 are 51% similar to >gi|16801074 in Listeria innocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0468 (1e-88).","

InterPro
IPR000445
Domain

Helix-hairpin-helix motif
PF00633	$\"[101-130]T$	HHH

InterPro
IPR003265
Domain

HhH-GPD
PF00730	$\"[36-172]T$	HhH-GPD
SM00478	$\"[40-188]T$	ENDO3c

InterPro
IPR003583
Domain

Helix-hairpin-helix DNA-binding, class 1
SM00278	$\"[111-130]T$	HhH1

InterPro
IPR004036
Domain

Endonuclease III, HhH
PS01155	$\"[104-133]T$	ENDONUCLEASE_III_2

InterPro
IPR005759
Family

Endonuclease III/Nth
TIGR01083	$\"[5-197]T$	nth

InterPro
IPR011257
Domain

DNA glycosylase
SSF48150	$\"[2-198]T$	DNA_glycsylse

noIPR
unintegrated

unintegrated
G3DSA:1.10.340.30	$\"[23-134]T$	G3DSA:1.10.340.30
PTHR10359	$\"[24-197]T$	PTHR10359

","BeTs to 16 clades of COG0177COG name: Predicted EndoIII-related endonucleaseFunctional Class: LThe phylogenetic pattern of COG0177 is amtkYQvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001502 (Endonuclease III) with a combined E-value of 2.1e-50. IPB001502A 35-56 IPB001502B 74-88 IPB001502C 102-133 IPB001502D 139-165 IPB001502E 179-206","Residues 6-57 are 51% similar to a (ENDONUCLEASE III COMPLETE PROTEOME) protein domain (PD100359) which is seen in Q9XA44_STRCO.Residues 60-148 are 58% similar to a (ENDONUCLEASE COMPLETE PROTEOME III) protein domain (PD001558) which is seen in Q9KC76_BACHD.Residues 60-153 are 43% similar to a (DNA LYASE GLYCOSIDASE GLYCOSYLASE) protein domain (PD007425) which is seen in O26858_METTH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 09:06:12 2002","Fri Feb 1 12:14:58 2002","Thu Oct 17 09:06:12 2002","Wed Apr 10 14:33:35 2002","Fri Feb 1 12:11:36 2002","Fri Feb 1 12:11:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1502 is paralogously related (blast p-value < 1e-3) to SMu1697, a predicted A/G-specific DNA glycosylase.","Fri Feb 1 12:14:58 2002","Fri Feb 1 12:11:36 2002","pdb|2ABK| Refinement Of The Native Structure Of Endonuclease ... 143 2e-035pdb|1MUY|A Chain A, Catalytic Domain Of Muty From Escherichia C... 68 1e-012pdb|1MUN| Catalytic Domain Of Muty From Escherichia Coli D13... 66 4e-012","SMU.1650c","","Residues 36 to 172 (E-value = 6.2e-26) place SMu1502 in the HhH-GPD family which is described as HhH-GPD superfamily base excision DNA repair protein (PF00730)Residues 101 to 130 (E-value = 6.2e-07) place SMu1502 in the HHH family which is described as Helix-hairpin-helix motif (PF00633)","Fri Feb 1 12:11:36 2002","","","","","","","1","","","SMU.1650c","777" "SMu1503","1571327","1570974","354","ATGCTGACATTTTACGAATATCCTAAATGCAGTACCTGTCGCCGTGCCAAAGCAGAATTAGACGATTTGGCTTGGGATTATGACGCAATTGATATCAAAAAGAATCCACCTGCAGCTAGTCTAATAAGGAATTGGCTAGAGAACAGCGGTCTAGAACTTAAGAAATTTTTCAACACATCAGGACAATCTTATCGTGCTCTGGGATTAAAAGATAAACTTCATCAACTAAGTCTTGATGAAGCAGCGAATTTATTAGCTAGCGATGGTATGCTCATCAAACGCCCGCTTTTAGTAAAAGAGGATAAAATAGTGCAAATAGGCTATCGAACAGCCTACGAAGATCTTGACTTTTAA","6.00","-0.86","13403","MLTFYEYPKCSTCRRAKAELDDLAWDYDAIDIKKNPPAASLIRNWLENSGLELKKFFNTSGQSYRALGLKDKLHQLSLDEAANLLASDGMLIKRPLLVKEDKIVQIGYRTAYEDLDF","1570990","","arsenate reductase","Cytoplasm, Periplasm","Significant hits in gapped BLAST to hypothetical proteins and arsenate reductase. Residues 1-115 are 61% similar to >gi15901312 in Streptococcus pneumoniae. Residues 18-116 are 61% similar to >gi15674546 in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1564 (3e-43).","

InterPro
IPR006504
Family

Conserved hypothetical protein, ArsC related
TIGR01617	$\"[2-117]T$	arsC_related

InterPro
IPR006660
Family

Arsenate reductase and related
PF03960	$\"[5-116]T$	ArsC

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[1-117]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[1-110]T$	IPR012336

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-97 are 56% similar to a (ARSENATE REDUCTASE ARSENICAL) protein domain (PD004262) which is seen in Q9K785_BACHD.Residues 5-97 are 60% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE MG127) protein domain (PD030877) which is seen in Q9CHE4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 1 12:30:37 2002","Fri Feb 1 12:28:25 2002","Thu Jul 13 11:52:19 2006","Fri Feb 1 12:28:25 2002","","Fri Feb 1 12:28:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1503 is paralogously related (blast p-value < 1e-3) to SMu1891, a predicted hypothetical protein (possible arsenate reductase), and SMu1044, a predicted arsenate reductase.","Fri Feb 1 12:31:39 2002","","No significant hits to the NCBI PDB database.","SMU.1651","","Residues 5 to 116 (E-value = 1.7e-34) place SMu1503 in the ArsC family which is described as ArsC family (PF03960)","Fri Feb 1 12:28:25 2002","24380029","","","Bennett MS, Guan Z, Laurberg M, Su XD.Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases.Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13577-82.PMID: 11698660Guan Z, Hederstedt L, Li J, Su XD.Preparation and crystallization of a Bacillus subtilis arsenate reductase.Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1718-21.PMID: 11679756","","Tue Feb 26 11:25:15 2002","1","","","SMU.1651","838" "SMu1504","1571858","1571364","495","ATGGTCCTTTACAAGCAGATTTATCATTCTCCTTTGGGAGATTTATCTCTTGTTGCAAATAATCAGGGTCTAATTGGCGTTTGGTTCCTTAATCAAAAATACTTTGAACAAGGATTGGAGGGAGAAACAGTCATAGAGCAAGCAAATACTATCTTAGATCAAGCCAAACAGTGGCTAGATACTTATTTTGCTGGGGAAAATCCTAATATGGTAAAGTTTCCTTTGAATCCACGGGGGACTGCTTTTCAAAAGCGCGTCTGGCAGGCCTTGTCTGAAATTCCTTGGGGACAGACTAGAGCTTATGGAGATATTGCTCAAAAAATAAACTGCCCATCCGCCCGAGCAATTGGTGGATCAGTTAGTCGCAATCCGTTAAGTATCATTATCCCTTGTCACCGTGTTCTTGGTGCTGCCGGTCAAATGACAGGCTATGCTGCTGGTATTGATAAAAAGATGTGGTTATTAGAGCATGAAGGCTTTAAAGTTGACAAGTAA","8.60","2.62","18293","MVLYKQIYHSPLGDLSLVANNQGLIGVWFLNQKYFEQGLEGETVIEQANTILDQAKQWLDTYFAGENPNMVKFPLNPRGTAFQKRVWQALSEIPWGQTRAYGDIAQKINCPSARAIGGSVSRNPLSIIIPCHRVLGAAGQMTGYAAGIDKKMWLLEHEGFKVDK","1571380","","methylated-DNA--protein-cysteine S-methyltransferase","Periplasm, Membrane, Cytoplasm","Significant hits in gapped BLAST to methylated-DNA--protein-cysteine S-methyltransferase. Residues 5-159 are 54% similar to >gi|15903360 in S. pneumoniae. Residues 2-158 are 42% similar to >gi|15672513 in Lactococcus lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1565 (3e-46).","

InterPro
IPR001497
Active_site

Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
PS00374	$\"[129-135]?$	MGMT

InterPro
IPR008332
Domain

Methylguanine DNA methyltransferase, ribonuclease-like
PF02870	$\"[2-77]T$	Methyltransf_1N

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[79-159]T$	Wing_hlx_DNA_bd

InterPro
IPR014048
Domain

Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
PF01035	$\"[79-163]T$	DNA_binding_1
TIGR00589	$\"[80-158]T$	ogt

noIPR
unintegrated

unintegrated
PTHR10815	$\"[43-163]T$	PTHR10815
SSF46767	$\"[79-161]T$	SSF46767
SSF53155	$\"[1-87]T$	SSF53155

","BeTs to 13 clades of COG0350COG name: Methylated DNA-protein cysteine methyltransferaseFunctional Class: LThe phylogenetic pattern of COG0350 is amtkyqv-EBRhuj---lin-Number of proteins in this genome belonging to this COG is 1","***** IPB001497 (Methylated-DNA--protein-cysteine methyltransferase) with a combined E-value of 2.4e-36. IPB001497A 79-105 IPB001497B 105-155","Residues 2-84 are 40% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD391322) which is seen in Q9CI35_LACLA.Residues 8-84 are 42% similar to a (METHYLTRANSFERASE) protein domain (PD029916) which is seen in Q9KKT3_VIBCH.Residues 85-158 are 57% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD002730) which is seen in OGT_MYCLE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 09:03:35 2002","Fri Feb 1 12:38:16 2002","Thu Oct 17 09:03:35 2002","Thu Oct 17 09:03:35 2002","Fri Feb 1 12:38:16 2002","Fri Feb 1 12:38:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1504 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 09:03:35 2002","Fri Feb 1 12:38:16 2002","pdb|1SFE| Ada O6-Methylguanine-Dna Methyltransferase From Es... 84 9e-018pdb|1EH6|A Chain A, Human O6-Alkylguanine-Dna Alkyltransferase 77 2e-015pdb|1QNT|A Chain A, X-Ray Structure Of Human O6alkylguanine-Dna... 75 4e-015","SMU.1652c","","Residues 79 to 163 (E-value = 2.3e-42) place SMu1504 in the Methyltransf_1 family which is described as 6-O-methylguanine DNA methyltransferase, DNA binding domain (PF01035)","Fri Feb 1 12:38:16 2002","","","","","","","1","","","SMU.1652c","958" "SMu1505","1573128","1571947","1182","ATGGTCTATAGTGTTAAAACCTTTAATAATATTAACCAAGTCGGTTTAAAAGAACTTGGCAATAAGTTTCAAGTAGATGGAGATTTAGCAGAAAATCCAGATGCTTATATTATTCGCAGTCAGAATTTACATGGGGTTGATTTTCCTAAAAATCTGAAAGCCATTGCACGCGCAGGTGCTGGAACAAATAATATTCCAATTACTGAAGCGACAGAAGCAGGTATTGTTGTTTTCAACACTCCTGGTGCTAATGCCAATGCTGTCAAAGAAGCAGTAATTGCTTCTCTTCTTTTTTCAGCGCGTGATTATATTTCAGCGAATGGCTGGGTTAATACTTTAACTGGTGATGATGTTCCTAAACAAGTTGAAGCTGGGAAAAAACAATTTGCAGGCAGTGAAATCGCTGGAAAAACCTTAGGAATTATTGGTCTAGGTGCGATTGGTGCTCGTATTGCTAATGATGCCCGCCGTTTAGGAATGAATGTTCTTGGTTATGATCCTTATGTTTCCATTGAAACTGCTTGGAATATCTCCAGTCATGTTAAGCGTGTCAATGATTTAAAAGATATTTTTGAGAATAGTGATTATATTACCATCCATGTTCCTTTAAATGATGAAACTAAAAATACCTTTAATGCTGATAGTTTTGCTCTTATGAATAAAGGGACAACTATTATTAATTTTGCCCGTGGTGAATTGGTTGACAATGAAGCGCTGTTTGAAGCGCTTGAAACAGGCACTGTTAAACGCTATATCACAGACTTTGGTACTGAAGAATTATTAAATAAGAAGGGGATTACTGTCTTTCCACACGTGGGAGGGTCAACTGAAGAAGCTGAACTCAACTGTGCTATTATGGCTGGTAAGACGATTCGTCGGTTTATAGAGACAGGAGAAATTACTAACTCTGTCAATTTTCCAAATATGCACCAAACTTTAACCGCACCTTATCGAATTACCTTAATTAATAAAAATGTTCCTAATATTGTAGCCCGTTTGTCAACTGCAGTTTCTAATTTAGATATCAATATCGCCAATATCTTGAACCGTTCAAAAGGAGATTATGCCTATACCATTTTGGATCTTGATGAAACAGATAAGGCAAAAATTGATGACCTAGTTGCCAATTTTGAAGCGAGCGACAATATTGTTCGTGTACGCTTAATCAAGGGCAAAAAATAA","5.60","-4.82","42785","MVYSVKTFNNINQVGLKELGNKFQVDGDLAENPDAYIIRSQNLHGVDFPKNLKAIARAGAGTNNIPITEATEAGIVVFNTPGANANAVKEAVIASLLFSARDYISANGWVNTLTGDDVPKQVEAGKKQFAGSEIAGKTLGIIGLGAIGARIANDARRLGMNVLGYDPYVSIETAWNISSHVKRVNDLKDIFENSDYITIHVPLNDETKNTFNADSFALMNKGTTIINFARGELVDNEALFEALETGTVKRYITDFGTEELLNKKGITVFPHVGGSTEEAELNCAIMAGKTIRRFIETGEITNSVNFPNMHQTLTAPYRITLINKNVPNIVARLSTAVSNLDINIANILNRSKGDYAYTILDLDETDKAKIDDLVANFEASDNIVRVRLIKGKK","1571963","For other 'ser' genes see SMu1508 (serC); SMu1161 (serB) and SMu1714 (serS).From PF00389 This enzyme catalyzes the oxidation of D-3-phosphoglycerate to 3-phosphohydroxypyruvate. This reaction is the first committed step in the 'phosphorylated' pathway of serine biosynthesis.See SMu1744, the phosphoglycerate dehydrogenase sequenced by Kawabata et al.","D-3-phosphoglycerate dehydrogenase","Cytoplasm","Significant hits in gapped BLAST to D-3-phosphoglycerate dehydrogenase. Residues 1-392 are 50% similar to >gi|15672586 in L. lactis. Residues 2-390 are 46% similar to >gi|16804861 in Listeria monocytogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1566 (1e-172).","

InterPro
IPR006139
Domain

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region
PF00389	$\"[50-305]T$	2-Hacid_dh

InterPro
IPR006140
Domain

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
PF02826	$\"[93-273]T$	2-Hacid_dh_C
PS00065	$\"[139-166]T$	D_2_HYDROXYACID_DH_1

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.260	$\"[307-390]T$	G3DSA:3.30.70.260
G3DSA:3.40.50.720	$\"[85-273]T$	G3DSA:3.40.50.720
PIRSF000121	$\"[3-388]T$	PGDH
PTHR10996	$\"[31-376]T$	PTHR10996
PTHR10996:SF10	$\"[31-376]T$	PTHR10996:SF10
SSF51735	$\"[84-275]T$	SSF51735
SSF52283	$\"[3-110]T$	SSF52283
SSF55021	$\"[306-389]T$	SSF55021

","BeTs to 12 clades of COG0111COG name: Phosphoglycerate dehydrogenaseFunctional Class: EThe phylogenetic pattern of COG0111 is amtkYqVcebrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002162 (D-isomer specific 2-hydroxyacid dehydrogenase) with a combined E-value of 6.1e-43. IPB002162A 64-101 IPB002162B 136-148 IPB002162C 187-200 IPB002162D 207-256 IPB002162E 260-279","Residues 272-389 are 27% similar to a (D-3-PHOSPHOGLYCERATE DEHYDROGENASE) protein domain (PD010940) which is seen in Q9KP92_VIBCH.Residues 153-271 are 59% similar to a (DEHYDROGENASE HYDROLASE NAD COMPLETE PROTEOME) protein domain (PD000699) which is seen in Q9CHW4_LACLA.Residues 272-392 are 61% similar to a (PROTEOME D-3-PHOSPHOGLYCERATE COMPLETE) protein domain (PD396581) which is seen in Q9CHW4_LACLA.Residues 1-60 are 45% similar to a (PROTEOME D-3-PHOSPHOGLYCERATE COMPLETE) protein domain (PD385397) which is seen in Q9CHW4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 8 09:30:58 2003","Fri Feb 1 12:42:32 2002","Thu Oct 17 09:01:45 2002","Wed Apr 10 14:36:34 2002","Fri Feb 1 12:42:32 2002","Fri Feb 1 12:42:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1505 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 11:35:28 2002","Fri Feb 1 12:42:32 2002","pdb|1PSD|A Chain A, D-3-Phosphoglycerate Dehydrogenase (Phospho... 127 2e-030pdb|1DXY| Structure Of D-2-Hydroxyisocaproate Dehydrogenase 76 7e-015pdb|2NAD|A Chain A, Nad-Dependent Formate Dehydrogenase (E.C.1.... 75 1e-014","SMU.1653c","","Residues 5 to 82 (E-value = 1.8e-07) place SMu1505 in the 2-Hacid_dh family which is described as D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (PF00389)Residues 88 to 271 (E-value = 9.3e-25) place SMu1505 in the 2-Hacid_dh_C family which is described as D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826)","Fri Feb 1 12:42:32 2002","","","","Kawabata S, Terao Y, Hamada S.Molecular cloning, sequence and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene.Oral Microbiol Immunol. 2000 Feb;15(1):58-62.PMID: 11155166","Tue Feb 26 11:40:29 2002","Tue Feb 26 11:40:29 2002","1","","","SMU.1653c","433" "SMu1506","1573726","1573214","513","ATGGCAGTCCTCAGTTCTGCCAAGCAATTTTTAGCAGAATCAGGATCTAGTCAGTGGCAGGGTGAAAATGGTTACCCCAACGAAGACGATGTCTTTGATGACATTTTGCAGGGGCAGGCTTATGTGGCGGTTGTTGGTGGACAAATTGTGGCTTATGCTGCAGTCATTGATGGCAAAGATGAGGCTTATGACAAAATTTATGATGGCAAATGGCAGCACAACAACTATCGTTATATCACCATCCATCGTCTAGCTGTCTTGCGAGATTTTGCGGGTCAAGGGATTGCTCAGACTTTCTTGCAGGGTCTGATTGAAGGTCAGGCTGGTTCAGATTTCCGTATTGATACGCATGAAAAGAACAAAGCTATGCGGCATATCGTTGAAAAATTAGGCTTTGTCTATTGCGGTAAAGTACCAATTGATGGTGAGCGTTTAGCTTATCAAAAAATCAAACAGAATAATGAGAATGCTCTCTATCAAGAAATTGATGAAGCAGATTATCATGGCTTTTAA","4.80","-7.84","19099","MAVLSSAKQFLAESGSSQWQGENGYPNEDDVFDDILQGQAYVAVVGGQIVAYAAVIDGKDEAYDKIYDGKWQHNNYRYITIHRLAVLRDFAGQGIAQTFLQGLIEGQAGSDFRIDTHEKNKAMRHIVEKLGFVYCGKVPIDGERLAYQKIKQNNENALYQEIDEADYHGF","1573230","","acetyltransferase","Cytoplasm","Significant hits in gapped BLAST to hypothetical proteins and acetyltransferases. Residues 1-152 are 57% similar to hypothetical protein (>gi|15903361) in Streptococcus pneumoniae R6. Residues 1-152 are 57% similar to acetyltransferase (>gi|15901314) in S. pneumoniae TIGR4.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1567 (1e-59).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[41-133]T$	Acetyltransf_1
PS51186	$\"[1-154]T$	GNAT

noIPR
unintegrated

unintegrated
SSF55729	$\"[1-144]T$	SSF55729

InterPro
IPR000192
Family

Aminotransferase, class V
PF00266	$\"[3-351]T$	Aminotran_5
PS00595	$\"[190-209]T$	AA_TRANSFER_CLASS_5

InterPro
IPR003248
Family

Phosphoserine aminotransferase
PD001544	$\"[242-358]T$	Pser_amintransf
TIGR01364	$\"[3-362]T$	serC_1

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[2-258]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015422
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 2
G3DSA:3.90.1150.10	$\"[259-363]T$	PyrdxlP-dep_Trfase_major_sub2

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[2-363]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PIRSF000525	$\"[1-363]T$	SerC
PTHR21152	$\"[3-362]T$	PTHR21152
PTHR21152:SF1	$\"[3-362]T$	PTHR21152:SF1

","BeTs to 3 clades of COG1932COG name: Phosphoserine aminotransferaseFunctional Class: H,EThe phylogenetic pattern of COG1932 is ----y---eb-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB003248 (Phosphoserine aminotransferase) with a combined E-value of 8.6e-154. IPB003248A 5-38 IPB003248B 56-86 IPB003248C 92-108 IPB003248D 147-159 IPB003248E 175-217 IPB003248F 239-286 IPB003248G 296-311 IPB003248H 326-358","Residues 3-49 are 68% similar to a (AMINOTRANSFERASE BIOSYNTHESIS) protein domain (PD347242) which is seen in SERC_LACLA.Residues 222-355 are 58% similar to a (AMINOTRANSFERASE BIOSYNTHESIS) protein domain (PD001544) which is seen in SERC_LACLA.Residues 56-218 are 63% similar to a (AMINOTRANSFERASE BIOSYNTHESIS) protein domain (PD339374) which is seen in SERC_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 16:00:21 2006","Fri Feb 1 12:51:36 2002","Thu Sep 14 16:00:21 2006","Wed Apr 10 14:47:15 2002","Fri Feb 1 12:51:36 2002","Fri Feb 1 12:51:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1508 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 12:03:27 2002","Thu Sep 14 16:00:21 2006","pdb1BT4A Chain A, Phosphoserine Aminotransferase From Bacillu... 333 3e-092pdb1BJOA Chain A, The Structure Of Phosphoserine Aminotransfe... 305 4e-084pdb1BJNA Chain A, Structure Of Phosphoserine Aminotransferase... 303 2e-083","SMU.1656c","","Residues 12 to 351 (E-value = 3.5e-56) place SMu1508 in the Aminotran_5 family which is described as Aminotransferase class-V (PF00266)","Fri Feb 1 12:51:36 2002","","","","Xie G, Brettin TS, Bonner CA, Jensen RA.Mixed-function supraoperons that exhibit overall conservation, albeit shuffled gene organization, across wide intergenomic distances within eubacteria.Microb Comp Genomics. 1999;4(1):5-28. Review.PMID: 10518299","","Tue Feb 26 12:03:27 2002","1","","","SMU.1656c","434" "SMu1509","1575829","1575488","342","ATGAAAAAAATAGAAGCTATTATTCGCTCTGATAAATTAGAAGATTTAAAAGCAGCCTTGGTTCAGTCAGGTTTTATCAAAGGAATGACTATTAGCCAAGTTCTAGGATTTGGGAATCAACGAGGTTATACAGAATATGTCCGTGGTCAAAAGATCACTCCAACGCTCTTAGCCAAAGTGAAAGTTGAAATTGTTGCTCATGATGCAGCAGTCGAAGAAATGATTACGACCATCAGCCAAGCAGTAAAGACAGGAGAAGTTGGTGATGGTAAGATATTTGTCAGTCCAGTTGATGAAATTGTTAGAATTCGTACAGGAGAACGTGATGGTGATGCCATTTAA","7.50","0.23","12287","MKKIEAIIRSDKLEDLKAALVQSGFIKGMTISQVLGFGNQRGYTEYVRGQKITPTLLAKVKVEIVAHDAAVEEMITTISQAVKTGEVGDGKIFVSPVDEIVRIRTGERDGDAI","1575504","For other 'gln' genes see SMu0516 (glnP);SMu0517 (glnQ); SMu0732 (glnP); SMu0328 (glnR); SMu0329 (glnA);SMu0741 (glnH);SMu1080 (glnP); SMu1380 (glnQ);SMu1381 (glnH); SMu1382 (glnM) and SMu1383 (glnP).","nitrogen regulatory protein PII","Cytoplasm","This sequence corresponds to the previously published 4098501 in GenBank, a predicted nitrogen regulatory factor. Significant hits in gapped BLAST to hypothetical protein and nitrogen regulatory protein P-II. Residues 1-113 are 72% similar to hypothetical protein (>gi|8574401) in Streptococcus thermophilus. Residues 1-113 are 62% similar to nitrogen regulatory protein P-II (>gi|15673573) in L. lactis.SMu1509 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002187
Family

Nitrogen regulatory protein P-II
PD001194	$\"[12-101]T$	PII_glnB
PR00340	$\"[2-17]T$ $\"[53-76]T$ $\"[84-104]T$	PIIGLNB
G3DSA:3.30.70.120	$\"[1-113]T$	PII_glnB
PF00543	$\"[4-106]T$	P-II
PS00638	$\"[84-97]T$	PII_GLNB_CTER

noIPR
unintegrated

unintegrated
SSF54913	$\"[1-113]T$	SSF54913

","BeTs to 9 clades of COG0347COG name: Nitrogen regulatory protein PIIFunctional Class: EThe phylogenetic pattern of COG0347 is AMT--QvcEbrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB002187 (Nitrogen regulatory protein P-II) with a combined E-value of 6.5e-42. IPB002187A 7-56 IPB002187B 61-109","Residues 1-113 are 72% similar to a (NITROGEN FIXATION REGULATORY REGULATION TRANSCRIPTION) protein domain (PD001194) which is seen in Q9K554_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 08:53:34 2002","Fri Feb 1 12:57:23 2002","Thu Oct 17 08:53:34 2002","Wed Apr 3 11:10:16 2002","Fri Feb 1 12:57:23 2002","Fri Feb 1 12:57:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1509 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 1 12:59:48 2002","Fri Feb 1 12:57:23 2002","pdb|2PII| Pii, Glnb Product >gi|1127243|pdb|1PIL| Signal Tr... 110 5e-026pdb|1GNK|B Chain B, Glnk, A Signal Protein From E. Coli >gi|582... 101 3e-023pdb|2GNK|A Chain A, Glnk, A Signal Protein From E. Coli 100 1e-022","SMU.1657c","","Residues 1 to 107 (E-value = 6.7e-38) place SMu1509 in the P-II family which is described as Nitrogen regulatory protein P-II (PF00543)","Fri Feb 1 12:57:23 2002","24380035","","","Tsinoremas,N.F., Castets,A.M., Harrison,M.A., Allen,J.F. andTandeau de Marsac,N.Photosynthetic electron transport controls nitrogen assimilation in cyanobacteria by means of posttranslational modification of theglnB gene productProc. Natl. Acad. Sci. U.S.A. 88 (11), 4565-4569 (1991)PubMed: 1905010","","Wed Apr 3 11:10:16 2002","1","","","SMU.1657c","" "SMu1510","1577080","1575845","1236","ATGGATTCAGGATCTATAGCATTTATTATCATTTGTTCTGCGCTTGTTTTTTTAATGACACCGGGTTTAGCCTTTTTCTATGGAGGCTTGGGACGCCGCAAGAATGTCATCAATACAATGATGATGGCAGTTGTGCCACTTGCTTTGGCCTCGCTTTTGTGGGTAGTTGTAGGTTATTCCTTATCTTTTAGTGGTGTTGGAAAAGTATTTGGTGATTTTTCACATGTCTTTTTGAATGGTGTGAAGGAAGGAGCAAGTAGTAGAGGGTTAACAATACCAGATACCTTATTTTCTGGTTTTCAAATGATGTTTTCTATCATTACAGTAGCTATTTTGACAGGTGCTGTTGCAGGAAGGATGCGTTTCACTCCTTTAGTTATTTTTATTATCTTTTGGTTACTTTTAGTCTATTATCCTTTTGCACACATGGTTTGGGATGATGGTCTATTAGCAAAATGGGGGACGCTTGATTTTGCCGGTGGTGATGTTGTCCACATTACATCAGGCGTTTCGGGGCTGGTATTAGCCTTGGTAGTCGGTAAACGTCGCGATTATGACCGTCTGGAATATCGTCCACATAATATTCCCTTTGTTCTTTTGGGAGCAGGCCTACTCTGGTTTGGTTGGTTTGGGTTTAATGCAGGTTCCGCTTTAGCTGCTAATGGTTTGGCTGTTCATGCTTTGTTGACAACTCATATTTCAGCTGCCGCTGCTATGTTCTCATGGCTGCTACTTGAAAAATATTTAAATGGTAAACCTTCCTTAGTAGGCGGTTCAACTGGTTTAGTCGCAGGCTTAGTTGCCATTACACCAGGTGCAGGCTTTGTACCCTTATGGAGCTCTTTGTTGATAGGACTCATGGTTAGTCCTCTATGTTATTTTGCTATCGCTGTGTTGAAAAGTAAATTTGGTTATGATGATGCCTTGGATGCTTTTGGCTGTCATGGTATAGGTGGTATTTTCGGAGGGATTGTAACAGGACTTTTTACAACACCTCATCTGGCTTTAGATAAATCCAATATTGGTCTTATTTATGGTAATGCAAGATTATTTTTAGTTATTCTGGCAGCTATTCTTTTTACGATTATTTGGTCAGCTCTGATTAGTTTTTTAATTATAAAAGTTATTTCCCTTTTCATGCCAATTCGTGTCAGTGATAGAGAAGAAGCTACTGGACTTGACGACAAAGAGCATGGAGAAACTGCGTATCCAACCTTTATGGGACTTGATTCTTAG","7.60","2.02","44007","MDSGSIAFIIICSALVFLMTPGLAFFYGGLGRRKNVINTMMMAVVPLALASLLWVVVGYSLSFSGVGKVFGDFSHVFLNGVKEGASSRGLTIPDTLFSGFQMMFSIITVAILTGAVAGRMRFTPLVIFIIFWLLLVYYPFAHMVWDDGLLAKWGTLDFAGGDVVHITSGVSGLVLALVVGKRRDYDRLEYRPHNIPFVLLGAGLLWFGWFGFNAGSALAANGLAVHALLTTHISAAAAMFSWLLLEKYLNGKPSLVGGSTGLVAGLVAITPGAGFVPLWSSLLIGLMVSPLCYFAIAVLKSKFGYDDALDAFGCHGIGGIFGGIVTGLFTTPHLALDKSNIGLIYGNARLFLVILAAILFTIIWSALISFLIIKVISLFMPIRVSDREEATGLDDKEHGETAYPTFMGLDS","1575861","","ammonium transporter, NrgA protein","Membrane, Cytoplasm","Significant hits in gapped BLAST to ammonium transporters. Residues 1-411 are 56% similar to >gi15673574 in L. lactis. Residues 1-407 are 36% similar to NRGA_BACSU.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1432 (1e-18).","

InterPro
IPR001905
Family

Ammonium transporter
PTHR11730	$\"[3-408]T$	Ammonium_transpt
TIGR00836	$\"[5-403]T$	amt
PS01219	$\"[157-182]T$	AMMONIUM_TRANSP

InterPro
IPR002229
Family

Blood group Rhesus C/E and D polypeptide
PR00342	$\"[101-117]T$ $\"[196-214]T$ $\"[260-273]T$ $\"[316-332]T$	RHESUSRHD

InterPro
IPR010256
Family

Rh-like protein/ammonium transporter
PF00909	$\"[7-403]T$	Ammonium_transp

noIPR
unintegrated

unintegrated
PTHR11730:SF3	$\"[3-408]T$	PTHR11730:SF3
SSF111352	$\"[1-384]T$	SSF111352

","BeTs to 10 clades of COG0004COG name: Ammonia permeasesFunctional Class: PThe phylogenetic pattern of COG0004 is AMT-YqvCebr----------Number of proteins in this genome belonging to this COG is 1","***** IPB001905 (Ammonium transporter family) with a combined E-value of 3.6e-117. IPB001905A 5-33 IPB001905B 100-132 IPB001905C 157-182 IPB001905D 193-216 IPB001905E 251-288 IPB001905F 303-329 IPB001905G 382-403","Residues 181-294 are 35% similar to a (GLYCOPROTEIN BLOOD GROUP RH50) protein domain (PD269036) which is seen in O67997_AZOBR.Residues 299-403 are 52% similar to a (AMMONIUM TRANSPORTER TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD334836) which is seen in Q9CF89_LACLA.Residues 1-63 are 76% similar to a (AMMONIUM TRANSPORTER COMPLETE PROTEOME) protein domain (PD002337) which is seen in Q9CF89_LACLA.Residues 96-167 are 63% similar to a (AMMONIUM TRANSPORTER TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD002520) which is seen in Q9CF89_LACLA.Residues 181-294 are 54% similar to a (AMMONIUM TRANSPORTER TRANSMEMBRANE) protein domain (PD001450) which is seen in Q9CF89_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 1 13:08:57 2002","Fri Feb 1 13:05:38 2002","Thu Jul 13 10:53:53 2006","Thu Oct 17 08:45:27 2002","Fri Feb 1 13:05:38 2002","Fri Feb 1 13:05:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1510 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Feb 1 13:08:57 2002","","No significant hits to the NCBI PDB database.","SMU.1658c","","Residues 7 to 403 (E-value = 6e-150) place SMu1510 in the Ammonium_transp family which is described as Ammonium Transporter Family (PF00909)","Fri Feb 1 13:05:38 2002","","","","Wray LV Jr, Zalieckas JM, Fisher SH.Purification and in vitro activities of the Bacillus subtilis TnrA transcription factor.J Mol Biol. 2000 Jun 30;300(1):29-40.PMID: 10864496 Wray LV Jr, Zalieckas JM, Ferson AE, Fisher SH.Mutational analysis of the TnrA-binding sites in the Bacillus subtilis nrgAB and gabP promoter regions.J Bacteriol. 1998 Jun;180(11):2943-9.PMID: 9603886O'Connell-Motherway,M., van Sinderen,D., Morel-Deville,F.,Fitzgerald,G.F., Ehrlich,S.D. and Morel,P.Six putative two-component regulatory systems isolated fromLactococcus lactis subsp. cremoris MG1363Microbiology 146 (Pt 4), 935-947 (2000)PubMed: 10784052","","Thu Jul 13 10:53:53 2006","1","","","SMU.1658c","832" "SMu1511","1578251","1577385","867","ATGCAAGTACAAAAAAGTTTTAAAGAACAAACAGCTTATGGGAAGCTTTATCTCGTGCCAACTCCTATTGGTAATCTTCAAGATATGACTTTTAGAAGTATTGCTATTTTAAAAAAGGTTGATTATATTGCGGCAGAAGATACCCGCAACACAGGACTCTTGCTGAAACACTTTGATATTTCAACACGTCAGCTTAGTTTTCATGAGCATAATGCTTTTGAAAAAATTCCTGATCTTCTGAAGCTCTTGAAATCTGGAAACTCTTTAGCTCAAGTATCTGATGCGGGTTTGCCAAGTATTTCTGACCCTGGATATGATTTGGTGCGGGCAGCTATTCAAGAAGATATAGCAGTTATAGCACTTCCGGGAGCTTCGGCTGGCATTACTGCTCTTATTGCTAGCGGTTTGGCTCCTCAACCTCATATTTTTTATGGTTTTTTACCACGCAAATCTGGTCAACAAAAGTCTTTTTTTGAGGAAAAAAAGTATTACCCAGAAACTCAAATTTTTTATGAATCGCCTTATCGGGTTCAGGAAACTTTAGAAAATATACTATCTGTCTATGGTGATAGACAGATAGTATTGACCAGAGAATTGACCAAACTTTATGAGGAATATCAAAGAGGAAATATTTCAGAAATCTTAACTTATATTGCAGAAAATCCTCTTAAGGGAGAATGCCTCTTACTGGTATCTGGCTATGATCATCAAGAAAAAGAGCAGCAGGTAAGTGAAGTTGAACTGAAACATTTGGTTGAAGCTTTAGTTAAAGAAGGTATGAAACCTAATCAAGCTATCAAAAAAGTAGCTAAAGAGAATGATTTCAATCGTCAAGAACTATATCAACTCTATCATGAATTACAGTAG","6.00","-4.34","32730","MQVQKSFKEQTAYGKLYLVPTPIGNLQDMTFRSIAILKKVDYIAAEDTRNTGLLLKHFDISTRQLSFHEHNAFEKIPDLLKLLKSGNSLAQVSDAGLPSISDPGYDLVRAAIQEDIAVIALPGASAGITALIASGLAPQPHIFYGFLPRKSGQQKSFFEEKKYYPETQIFYESPYRVQETLENILSVYGDRQIVLTRELTKLYEEYQRGNISEILTYIAENPLKGECLLLVSGYDHQEKEQQVSEVELKHLVEALVKEGMKPNQAIKKVAKENDFNRQELYQLYHELQ","1577401","","conserved hypothetical protein, tetrapyrrole methylase family","Cytoplasm","Significant hits in gapped BLAST to hypothetical proteins and tetrapyrrole methylase family protein. Residues 1-287 are 71% similar to >gi15674543 in S. pyogenes. Residues 1-286 are 70% similar to >gi15900818 in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1572 (1e-113).","

InterPro
IPR000878
Domain

Tetrapyrrole methylase
PF00590	$\"[15-215]T$	TP_methylase
SSF53790	$\"[13-237]T$	Cor/por_Metransf

InterPro
IPR008189
Family

Protein of unknown function UPF0011
PIRSF005917	$\"[13-288]T$	Mtase_YraL
TIGR00096	$\"[15-288]T$	UPF0011
PS01296	$\"[93-104]T$	UPF0011

InterPro
IPR014777
Domain

Tetrapyrrole methylase, subdomain 1
G3DSA:3.40.1010.10	$\"[14-124]T$	4pyrrole_Mease_sub1

noIPR
unintegrated

unintegrated
PTHR21091	$\"[56-258]T$	PTHR21091
PTHR21091:SF18	$\"[56-258]T$	PTHR21091:SF18

","BeTs to 12 clades of COG0313COG name: Predicted methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0313 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000578 (Uncharacterized protein family UPF0011) with a combined E-value of 7.7e-71. IPB000578A 16-55 IPB000578B 89-108 IPB000578C 121-150 IPB000578D 167-177 IPB000578E 193-206","Residues 16-230 are 69% similar to a (COMPLETE PROTEOME SAM-DEPENDENT TRANSFERASE) protein domain (PD333223) which is seen in Q9CIG0_LACLA.Residues 231-287 are 47% similar to a (PROTEOME COMPLETE YEAE) protein domain (PD383943) which is seen in Q9CIG0_LACLA.Residues 191-283 are 34% similar to a (F27F5.18) protein domain (PD274986) which is seen in Q9MAJ9_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:03:25 2002","Thu Sep 14 16:04:45 2006","Thu Sep 14 16:04:45 2006","Wed Oct 9 08:03:25 2002","Fri Feb 1 13:12:26 2002","Fri Feb 1 13:12:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1511 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:03:25 2002","","No significant hits to the NCBI PDB database.","SMU.1659c","","Residues 15 to 215 (E-value = 1.6e-35) place SMu1511 in the TP_methylase family which is described as Tetrapyrrole (Corrin/Porphyrin) Methylases (PF00590)","Fri Feb 1 13:12:26 2002","24380037","","","","","","1","","","SMU.1659c","435" "SMu1512","1578589","1578257","333","ATGGATAAAAAAGACTTATTTGATGTTTTTGATGGTTTTTCACAAAATTTGATGGAAACTTTGGCTGAAGCGGAAGCCTTAAAGAAACAAGTGCAGGATTTAGTAGAGCAAAATGCGTCTTTACGTTTGGAAAATGATAAGCTAAGAGACCGTCTTAGCCATTTTAGCCAGATGGAAGAAAGTGATCCTAGCAGTAAGGCAATTAGTTCTAGAAAAGAAAACCTTGAAAACATTTATGAAGATGGTTTCCATATTTGCACTTTCTTTTATGGGCAAAGACGAGAAAATAATGAGGATTGTGCTTTCTGTATGGAATTGTTGTATCGAGAGTAG","4.40","-9.66","12969","MDKKDLFDVFDGFSQNLMETLAEAEALKKQVQDLVEQNASLRLENDKLRDRLSHFSQMEESDPSSKAISSRKENLENIYEDGFHICTFFYGQRRENNEDCAFCMELLYRE","1578273","","conserved hypothetical protein","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-110 are 64% similar to >gi|15674542 in S. pyogenes. Residues 1-110 are 57% similar to >gi|15902881 in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1573 (4e-34).","

InterPro
IPR010377
Family

Protein of unknown function DUF972
PF06156	$\"[1-109]T$	DUF972

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-107 are 35% similar to a (PROTEOME COMPLETE BH0046 XPAC-ABRB) protein domain (PD076467) which is seen in Q9KGL5_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:01:51 2002","Fri Feb 1 13:14:55 2002","Wed Oct 9 08:01:51 2002","Fri Feb 1 13:14:55 2002","","Fri Feb 1 13:14:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1512 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:01:51 2002","","No significant hits to the NCBI PDB database.","SMU.1660c","","Residues 1 to 109 (E-value = 2.4e-68) place SMu1512 in the DUF972 family which is described as Protein of unknown function (DUF972) (PF06156)","Fri Feb 1 13:14:55 2002","24380038","","","","","","1","","","SMU.1660c","959" "SMu1513","1579388","1578582","807","ATGATAGAAGTAATTGGTATCAAATACGAAGAAACGGATAGCATTAGTTATGTACTGCCTGATCGGACCTATCAAAAGGATGATTTCCTTGTCGTTCAGAATCGTAAGGGAAGCCGTTTAGCACAAGTCGTTCAGGAAAATTTTGCTATGTCAGCCGACAAGCTTCCAGACATAGAGCAAATAGATAAAGTTTTGAGAAAGGCAGAGCAAGCAGATATTGAGACTTATCAGAACAATTTAATTTTAGCAGAAGAAAGTTTTGCTAAAGTTAATGCACTTATCCAAAAAAATCAATTAGAAATGAAATTGATTGATATTGTTTTTCCTTTGGAACGTCGGCAAGTCTTGATTACCTTTGTTGCAGAGCATCGTGTTGATTTTCGTCAGCTCTTAAAAGATTTGGCCAATTTTTTTAAAGCAAGGATTGAATTACGCCAAATCAACAGTCGTGAAGAAAGTAAAATTTATGGCGGTCTGGGTCCGTGCGGCCGTGCTCTTTGTTGCTCAAGCTTTCTTGGCGAGTTTCCGCCGGTTTCTATCAAAATGGCAAAGAATCAAAACTTATCTCTGAATTCTGGGAAAACAACAGGAGTCTGTGGCCGTCTTATGTGCTGTTTAAGTTTTGAAGATGATTTTTATCGTGAATCCAAAGAAAAATTTCCTGATTTAGGTACTAAGGTCAATACTCAAAATGGCCAAGGTATTATTGCTGGTATTGATGTTATTTCTGAAACTGTTAAGGTTCGTTTTGAAGAAACTCCTGGTCTTTTGACCTATGCATTAGAGGAGGTCAAGATCAATGGATAA","5.20","-4.02","30359","MIEVIGIKYEETDSISYVLPDRTYQKDDFLVVQNRKGSRLAQVVQENFAMSADKLPDIEQIDKVLRKAEQADIETYQNNLILAEESFAKVNALIQKNQLEMKLIDIVFPLERRQVLITFVAEHRVDFRQLLKDLANFFKARIELRQINSREESKIYGGLGPCGRALCCSSFLGEFPPVSIKMAKNQNLSLNSGKTTGVCGRLMCCLSFEDDFYRESKEKFPDLGTKVNTQNGQGIIAGIDVISETVKVRFEETPGLLTYALEEVKING","1578598","","signal peptidase II","Cytoplasm","Significant hits in gapped BLAST to signal peptidase-like protein. Residues 1-268 are 41% similar to >gi|15612608 in B halodurans. Residues 1-265 are 40% similar to >gi|16799283 in L. innocua.SMu1513 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR007557
Domain

PSP1 C-terminal conserved region
PF04468	$\"[60-147]T$	PSP1

noIPR
unintegrated

unintegrated
PTHR21600	$\"[78-246]T$	PTHR21600
PTHR21600:SF3	$\"[78-246]T$	PTHR21600:SF3

","BeTs to 5 clades of COG1774COG name: Uncharacterized ACR, PSP1 homologsFunctional Class: SThe phylogenetic pattern of COG1774 is ----Yqv--b-------l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 30-209 are 47% similar to a (PROTEOME COMPLETE XPAC-ABRB YEAC) protein domain (PD013732) which is seen in Q9KGL6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 12:21:41 2002","Fri Feb 1 13:18:03 2002","Thu Oct 17 08:42:50 2002","Thu Oct 17 08:42:50 2002","","Fri Feb 1 13:18:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1513 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 12:21:41 2002","","No significant hits to the NCBI PDB database.","SMU.1661c","","Residues 60 to 147 (E-value = 4.5e-26) place SMu1513 in the PSP1 family which is described as PSP1 C-terminal conserved region (PF04468)","Fri Feb 1 13:18:03 2002","24380039","","","Tjalsma H, Kontinen VP, Pragai Z, Wu H, Meima R, Venema G, Bron S, Sarvas M, van Dijl JM.The role of lipoprotein processing by signal peptidase II in the Gram-positive eubacterium bacillus subtilis. Signal peptidase II is required for the efficient secretion of alpha-amylase, a non-lipoprotein.J Biol Chem. 1999 Jan 15;274(3):1698-707.PMID: 9880550","","Tue Feb 26 12:21:41 2002","1","","","SMU.1661c","" "SMu1514","1580260","1579385","876","ATGGAATTAGAAAAACTACAGCCTAAAATTTTTCAAGAATTTCAGCGAATTTTACAATCTGGCAAGCTGAGCCATGCTTATTTGTTTTCGGGGGATTTTGCTAGTTTTGAAATGGCTGTTTTGTTGGCTCAGAGCCGTTTTTGTGACAGTCCTATTGATGCTCTTCCTTGTGGGCAGTGCCGTTCCTGCCGGTTAATTGCTGAAAATGATTTTTCGGATGTTAAAGTCATTGAACCTGAAGGGCAAATGATTAAAACAGCAACGATCCGTGATTTGCTGCGTGAATTTTCCAGTTCAGGATTTGAAGGACAGTCACAGGTTTTTATTATTCGTGATGCTGATAAAATGCATACTAATGCCGCTAATAGCTTGCTAAAGTTTATTGAAGAGCCACAAAGTGATACTTATATGATTTTATTAACTCAAGATGAAAGTAGGATATTGCCTACGATTAAAAGTCGAACTCAAATTTTCTATTTTCCTAAGAATAGGGCTTATTTAATCCAACAGTTAGAACAGGAAGGACTACTCAAAAGCCAAGCAGAAATACTAGCGGATCTATCTAAAGATCCGACACAAGCAAAAGAATTTGCACAAAATAATAAATTGCTGGACTTGTTAAAAGCCTGTGAACGTTTTACCGCTATCTTATTTGACAGTAAAAATCTTGCTTATTTAGAAGTGTCACGGTTGGCTCAGCTAGCTAGCGAAAAATCCGAACAGGAATGGGTCTTTCAATTGTTAACTTTCTTTTTATCAAAAAATTATGATAAAAGGGAAACTTTAAGTTACTTAGAAGCTATTTATCAAGCCAAAAAAATGTGGTTTAGTAATGTAAGTTTTCAAAATGCACTGGAATATATGGTGATAACATGA","5.10","-5.73","33570","MELEKLQPKIFQEFQRILQSGKLSHAYLFSGDFASFEMAVLLAQSRFCDSPIDALPCGQCRSCRLIAENDFSDVKVIEPEGQMIKTATIRDLLREFSSSGFEGQSQVFIIRDADKMHTNAANSLLKFIEEPQSDTYMILLTQDESRILPTIKSRTQIFYFPKNRAYLIQQLEQEGLLKSQAEILADLSKDPTQAKEFAQNNKLLDLLKACERFTAILFDSKNLAYLEVSRLAQLASEKSEQEWVFQLLTFFLSKNYDKRETLSYLEAIYQAKKMWFSNVSFQNALEYMVIT","1579401","For DNA polymerase III,beta subunit see SMu0002. For DNA polymerase III, alpha subunit see SMu0110. For DNA polymerase III subunits gamma / tau see SMu1437. ","DNA polymerase III delta prime subunit","Cytoplasm","Significant hits in gapped BLAST to DNA polymerase III delta' subunits. Residues 1-291 are 52% similar to >gi15674540 in S. pyogenes. Residues 1-292 are 52% similar to >gi11992993 in S. pyogenes. Residues 1-290 are 46% similar to >gi15672381 in L. lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1574 (1e-92).","

InterPro
IPR004622
Domain

DNA polymerase III, delta prime subunit
TIGR00678	$\"[11-195]T$	holB

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-160]T$	G3DSA:3.40.50.300
PTHR11669	$\"[80-162]T$	PTHR11669
SSF52540	$\"[1-200]T$	SSF52540

","BeTs to 13 clades of COG0470COG name: ATPase involved in DNA replicationFunctional Class: LThe phylogenetic pattern of COG0470 is AMTKYQVCEBRHUJGPOLINXNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 108-258 are 28% similar to a (MG007 III PROTEOME SUBUNIT) protein domain (PD039113) which is seen in Q9PRC6_UREPA.Residues 128-248 are 41% similar to a (DNA POLYMERASE DELTA' III) protein domain (PD407538) which is seen in Q9CIG3_LACLA.Residues 19-126 are 61% similar to a (DNA POLYMERASE III SUBUNIT) protein domain (PD345569) which is seen in Q9CIG3_LACLA.Residues 7-141 are 29% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9JTS1_NEIMA.Residues 56-127 are 48% similar to a (DNA POLYMERASE III SUBUNIT) protein domain (PD035127) which is seen in Q9KGL7_BACHD.Residues 103-160 are 41% similar to a (III PROTEOME GAMMA COMPLETE) protein domain (PD178189) which is seen in O83533_TREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 28 10:35:35 2002","Thu Aug 31 14:15:20 2006","Thu Aug 31 14:15:20 2006","Thu Mar 28 09:18:26 2002","","Thu Aug 31 14:15:20 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1514 is paralogously related (blast p-value < 1e-3) to SMu1437, a predicted DNA polymerase III, gamma/tau subunit.","Fri Feb 1 13:22:38 2002","Thu Aug 31 14:11:12 2006","pdb1A5T Crystal Structure Of The Delta Prime Subunit Of The... 80 4e-016","SMU.1662c","","No significant hits to the Pfam 11.0 database","Fri Feb 1 13:21:37 2002","","","","Song MS, Dallmann HG, McHenry CS.Carboxyl-terminal domain III of the delta' subunit of the DNA polymerase III holoenzyme binds delta.J Biol Chem. 2001 Nov 2;276(44):40668-79.PMID: 11518714","","Thu Aug 31 14:15:20 2006","1","","","SMU.1662c","591" "SMu1515","1580911","1580273","639","ATGACAAAGGGAATTTTTATTTCATTTGAAGGACCAGATGGAGCCGGAAAGACGACAGTTTTAGAGGCTATTTTACCTCAATTAAAAAAACTTGTTGCAAAAGAGGTTATCACAACACGCGAACCCGGTGGTGTTGCTATTGCAGAAAGTATTCGGGATCTTATTCTTGATGTTAATCATACTAATATGGACGATAAGACAGAATTACTTCTTTATATTGCGGCTCGTCGTCAGCATTTGGTTGAGAGGATTTTACCTGAGTTGAAAAAAGGCAATCTTGTTCTTGTGGATCGTTTTATTGACAGTTCTGTTGCTTATCAAGGCTATGGCAGAGGACTTGATGCTGATGCAGTTACGTGGCTGAATAACTTTGCAACAGATGGTTTGCAACCAGATCTAACACTTTATTTTGACGTTGATTCACAGATTGGTCTTACTCGAATCGAGAAGAATAAAGAACGTGAAGTCAATCGACTTGATTTAGAACAATTAGATATGCATCGCCGTGTACGTTCAGGTTATTTGAAATTGGCTCAGGAAAATCCTGATCGGATTGTTACCATTGATGCGGCTCGTCCTTTGGAAGAAGTTATTACTGATGCCTTATTTATAATCAAACAAAGATGTTTAGAAAAGTAA","5.30","-4.31","23940","MTKGIFISFEGPDGAGKTTVLEAILPQLKKLVAKEVITTREPGGVAIAESIRDLILDVNHTNMDDKTELLLYIAARRQHLVERILPELKKGNLVLVDRFIDSSVAYQGYGRGLDADAVTWLNNFATDGLQPDLTLYFDVDSQIGLTRIEKNKEREVNRLDLEQLDMHRRVRSGYLKLAQENPDRIVTIDAARPLEEVITDALFIIKQRCLEK","1580289","","thymidylate kinase","Cytoplasm","Significant hits in gapped BLAST to thymidylate kinase. Residues 1-202 are 69% similar to >gi|15674539 in S. pyogenes. Residues 1-198 are 65% similar to >gi|15902879 in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1575 (3e-80).","

InterPro
IPR000062
Domain

Thymidylate kinase
PF02223	$\"[9-201]T$	Thymidylate_kin
TIGR00041	$\"[1-201]T$	DTMP_kinase
PS01331	$\"[95-107]T$	THYMIDYLATE_KINASE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-208]T$	G3DSA:3.40.50.300
PIRSF000737	$\"[5-205]T$	dTMP_kin
PTHR10344	$\"[1-212]T$	PTHR10344
SSF52540	$\"[2-207]T$	SSF52540

","BeTs to 17 clades of COG0125COG name: Thymidylate kinaseFunctional Class: FThe phylogenetic pattern of COG0125 is AmTkyqvceBrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000062 (Thymidylate kinase) with a combined E-value of 1.4e-32. IPB000062A 6-19 IPB000062B 63-76 IPB000062C 84-107 IPB000062D 131-147","Residues 6-82 are 42% similar to a (KINASE NUCLEOTIDE THYMIDYLATE) protein domain (PD403036) which is seen in KTHY_ECOLI.Residues 93-206 are 63% similar to a (KINASE THYMIDYLATE TRANSFERASE NUCLEOTIDE) protein domain (PD002766) which is seen in Q9CIG4_LACLA.Residues 5-82 are 60% similar to a (KINASE THYMIDYLATE TRANSFERASE NUCLEOTIDE) protein domain (PD375183) which is seen in Q9CIG4_LACLA.Residues 5-76 are 43% similar to a (KINASE THYMIDYLATE TRANSFERASE) protein domain (PD104249) which is seen in KTHY_CHLTR.Residues 7-76 are 41% similar to a (KINASE THYMIDYLATE ATP-BINDING) protein domain (PD361357) which is seen in KTHY_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 12:35:48 2002","Fri Feb 1 13:26:12 2002","Thu Oct 17 08:38:56 2002","Thu Oct 17 08:38:56 2002","Fri Feb 1 13:26:12 2002","Fri Feb 1 13:26:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1515 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 12:35:48 2002","Fri Feb 1 13:26:12 2002","pdb|4TMK|A Chain A, Complex Of E. Coli Thymidylate Kinase With ... 135 5e-033","SMU.1663c","","Residues 9 to 201 (E-value = 3.5e-66) place SMu1515 in the Thymidylate_kin family which is described as Thymidylate kinase (PF02223)","Fri Feb 1 13:26:12 2002","","","","Li de la Sierra I,Munier-Lehmann H, Gilles AM, Barzu O, Delarue M.X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.J Mol Biol. 2001 Aug 3;311(1):87-100.PMID: 11469859","","Thu Oct 17 08:38:56 2002","1","","","SMU.1663c","708" "SMu1516","1581647","1580988","660","ATGCCAGTAAAGGATTTTATGACAAGGAGAGTTGTTTATATTTCTCCAGATACAACTGTAGCCAAGGCGACAGATATCATGCGTGAGAAAAATTTGCGCCGTCTTCCGGTTATTGAAAATGATGTTTTAGTTGGTTTGCTGACTGAGGGAACTATCGCTGATGCTAATCCATCTAAAGCAACAAGTCTTTCTATTTATGAAATGAACTATCTTTTAAATAAGACCAAAGCCCGCGATGTTATGATTAAAGATGTTATTACGGTTTCAAAAGATGATCGTTTAGAAGATGCGATTTATATTATGATGAAGCATAAAATTGGTGTCTTGCCTGTTGTTGATGGCAATCAGATGTCAGGTATCATCACTGATAAAGATGTTTTTCGTGCCTTTTTGGAAGTTTCTGGTTATGGTAAAGAGGGGATCCGGATAAGACTTTTAGCTGATGATAAAGTTGGTATTTTAGAACAGGTTGTAAAAGATATTTCTGATGAAAAGCTCAATATTAAGCGGATTGTTGTTTCTGGACGTCGGGAAGATAAGGTTATCATTGAGATTCAGATTGATGGTAGATTTACCAGTGAATCTCTAAAACAAAAACTGCTTAATCAAGGCTTTACAATTGAGTCTATTGAACAGACTGAAAGAAAGACTGATTTTTAA","7.50","0.25","24820","MPVKDFMTRRVVYISPDTTVAKATDIMREKNLRRLPVIENDVLVGLLTEGTIADANPSKATSLSIYEMNYLLNKTKARDVMIKDVITVSKDDRLEDAIYIMMKHKIGVLPVVDGNQMSGIITDKDVFRAFLEVSGYGKEGIRIRLLADDKVGILEQVVKDISDEKLNIKRIVVSGRREDKVIIEIQIDGRFTSESLKQKLLNQGFTIESIEQTERKTDF","1581004","For other 'acu' genes see SMu0113 (acuC). ","acetoin utilization protein, acetoin dehydrogenase","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins and acetoin utilization protein AcuB. Residues 1-216 are 62% similar to >gi15902708 in S. pneumoniae. Residues 1-168 are 43% similar to >gi15643897 in Thermotoga maritima.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1577 (6e-74).","

InterPro
IPR000644
Domain

Cystathionine-beta-synthase
PF00571	$\"[5-131]T$	CBS
SM00116	$\"[10-57]T$ $\"[84-131]T$	CBS

noIPR
unintegrated

unintegrated
PTHR11911	$\"[1-163]T$	PTHR11911
PTHR11911:SF5	$\"[1-163]T$	PTHR11911:SF5
SSF54631	$\"[1-55]T$ $\"[71-132]T$	SSF54631
SSF55021	$\"[130-212]T$	SSF55021

","BeTs to 13 clades of COG0517COG name: CBS domainsFunctional Class: RThe phylogenetic pattern of COG0517 is AMTKYQVCEBRHUJgpo-inxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 88-214 are 29% similar to a (PROTEOME COMPLETE) protein domain (PD310279) which is seen in Q9WZZ4_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jul 13 12:34:06 2006","Fri Feb 1 13:30:38 2002","Thu Jul 13 12:34:06 2006","Thu Apr 4 14:08:54 2002","","Fri Feb 1 13:30:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1516 is paralogously related (blast p-value < 1e-3) to SMu1957, a predicted inosine monophosphate dehydrogenase (IMP dehydrogenase), and SMu1920, a predicted glycine betaine/carnitine/choline ABC transporter, ATP-binding protein, opuCA.","Fri Feb 1 13:32:59 2002","","No significant hits to the NCBI PDB database.","SMU.1664c","","Residues 5 to 57 (E-value = 4.4e-15) place SMu1516 in the CBS family which is described as CBS domain (PF00571)Residues 79 to 131 (E-value = 2.7e-17) place SMu1516 in the CBS family which is described as CBS domain (PF00571)","Thu Jul 13 12:34:06 2006","24380042","","","Grundy FJ, Waters DA, Takova TY, Henkin TM.Identification of genes involved in utilization of acetate and acetoin in Bacillus subtilis.Mol Microbiol. 1993 Oct;10(2):259-71.PMID: 7934817","","Fri Feb 1 13:30:38 2002","1","","","SMU.1664c","840" "SMu1517","1582473","1581763","711","ATGGCGATGTTAAAAGTTGAGAATTTATCTGTTCATTATGGTGTTATCCAAGCAGTCAAAGATGTGTCTTTTGACGTCAATGAAGGGGAAGTCGTTTCTCTTATTGGTGCCAATGGTGCTGGCAAGACCTCTATTTTACGAACTATTTCGGGTTTGGTGCGTCCAAGTTCAGGGGAAATTAATTTTTTAGGAAATGATATTCAAAAAGCTGCAACTCGAAAAATTGTAGCTTCTGGTCTGTCTCAGGTTCCAGAAGGGCGACATGTTTTTCCTGGTTTAACAGTTTTAGAAAACTTAGAAATGGGAGCTTTTTTGAGCAATAATCGTGAGGAAAATCTAGCACGCTTAAAAAGAGTGTTTGAACGTTTCCCGCGCTTGGAAGAGCGTAAAAATCAAGATGCAGCAACCCTTTCTGGCGGTGAGCAGCAAATGCTTGCCATGGGGCGTGCTCTCATGAGTCAGCCTAAGCTGCTTTTGCTTGATGAGCCATCTATGGGATTGGCACCAATTTTTATACAAGAAATTTTTGACATCATTCAAGATATTCAAAAGCAGGGGACAACAGTGCTTTTGATTGAGCAAAATGCTAAGAAGGCCCTGTCAATTGCAGATCGTGGCTATGTTTTGGAAACTGGAAAGATTGTTCTTTCAGGTACAGGCAAAGAATTATTGGCTTCTGATGAAGTTCAAAAAGCTTATTTAGGTGGATAA","6.00","-1.51","25577","MAMLKVENLSVHYGVIQAVKDVSFDVNEGEVVSLIGANGAGKTSILRTISGLVRPSSGEINFLGNDIQKAATRKIVASGLSQVPEGRHVFPGLTVLENLEMGAFLSNNREENLARLKRVFERFPRLEERKNQDAATLSGGEQQMLAMGRALMSQPKLLLLDEPSMGLAPIFIQEIFDIIQDIQKQGTTVLLIEQNAKKALSIADRGYVLETGKIVLSGTGKELLASDEVQKAYLGG","1581779","For other components see SMu1518 (NBD1); SMu1520 (MSD1); SMu1519 (MSD2) and SMu1521 (SBP1).For other 'liv' genes see SMu1518 (livG); SMu1519 (livM); SMu1520 (livH); SMu1521 (livK) and SMu1316 (livG).","branched chain amino acid ABC transporter, ATP-binding protein","Membrane, Cytoplasm","Significant hits in gapped BLAST to branched-chain ABC transporter ATP-binding proteins. Residues 1-236 are 81% similar to >gi|15900648 in S. pneumoniae. Residues 2-235 are 56% similar to >gi|7480525 in S.coelicolor. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1578 (2e-99).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[136-169]T$	ABC_transporter
PF00005	$\"[29-212]T$	ABC_tran
PS00211	$\"[137-151]?$	ABC_TRANSPORTER_1
PS50893	$\"[4-236]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-215]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-235]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-233]T$	PTHR19222
PTHR19222:SF13	$\"[4-233]T$	PTHR19222:SF13
SSF52540	$\"[3-235]T$	SSF52540

","BeTs to 4 clades of COG0410COG name: High-affinity branched amino acid transport system ATPaseFunctional Class: EThe phylogenetic pattern of COG0410 is Am----vCe------------Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.8e-23. IPB001140A 18-64 IPB001140B 134-172 IPB001140C 189-218","Residues 186-235 are 64% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD051514) which is seen in Q9S2J1_STRCO.Residues 74-132 are 47% similar to a (ATP-BINDING PROTEOME COMPLETE ACID) protein domain (PD236901) which is seen in Q9RVJ4_DEIRA.Residues 9-219 are 24% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 19-69 are 58% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9S2J1_STRCO.Residues 136-169 are 94% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9S2J1_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 08:31:11 2002","Fri Feb 1 13:34:56 2002","Thu Oct 17 08:31:11 2002","Wed Apr 10 14:52:26 2002","Fri Feb 1 13:34:56 2002","Fri Feb 1 13:34:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1517 is paralogously related (blast p-value < 1e-3) to branched chain amino acid ABC transporter, ATP-binding proteins: SMu1518, SMu0971, SMu0517, SMu0218, SMu1003, SMu1410, SMu1380, SMu0374, SMu0258, SMu0418, SMu1079, SMu1036, SMu1920, SMu0884, SMu0731, SMu1710, SMu1023, SMu0849, SMu1068, SMu0950, SMu0976, SMu1210, SMu1246, SMu1231, SMu0596, SMu0594, SMu0390, SMu0335, SMu1649, SMu0235, SMu1949, SMu0216, SMu1950, SMu1762, SMu1316, SMu0786, SMu0234, SMu0916, SMu0805, SMu1724, SMu0907, SMu1428, SMu0944, SMu0476, SMu0164, SMu1037, SMu0987, SMu1001, SMu0475, SMu1757, SMu1288, SMu1751, SMu0666, SMu1811, SMu0824, SMu0836, SMu0825, SMu1050, SMu0837, SMu1093, SMu0752, SMu1545, SMu1065, SMu0986, SMu1959, SMu0024, SMu1064, SMu0224, SMu0823, SMu1306, SMu0729, SMu1686, and SMu1202, all ATP-binding proteins.","Tue Feb 26 12:39:32 2002","Fri Feb 1 13:34:56 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 94 1e-020pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 89 7e-019","SMU.1665c","","Residues 29 to 212 (E-value = 2.5e-49) place SMu1517 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Feb 1 13:34:56 2002","","","","Qi,F., Chen,P. and Caufield,P.W.Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in streptococcus mutansAppl. Environ. Microbiol. 65 (2), 652-658 (1999)PubMed: 9925596","Thu Apr 25 17:52:30 2002","Wed Apr 10 14:52:26 2002","1","","","SMU.1665c","436" "SMu1518","1583237","1582473","765","ATGGCACTTCTTGATGTAAAAAATTTAACAAAAAATTTCGGTGGTCTGACAGCTGTTGGGGATGTTACTCTGGAGCTTAATGAGGGAGAATTGGTCGGTCTGATTGGTCCTAATGGGGCAGGTAAGACTACACTTTTTAATTTATTGACTGGTGTCTATGAACCAAGTGAAGGAAGTGTGGAACTTGATGGTACTCTTTTAAATGGGAAGACACCTTATAAGATTGCTTCTTTAGGACTATCTCGTACTTTCCAAAATATTCGCCTCTTTAAGAATATGACCGTTATCGAAAATGTTTTAGTCGGTATGGAAAATACGCGCAATCCTCATCTCTTTTCGAGTTTTCTGCGCTTACCAAGTTTTTATTCAAATGAAACGGACTTACAGGAAAAAGCCATTGAACTTCTAAAAATTTTCAACTTAGATGACAAGGCTGATACTTTAGCGAAAAATCTTCCTTATGGACAGCAGCGGCGCTTGGAAATTGTGCGTGCACTGGCTACTAAGCCCAAAATCCTCTTTTTAGATGAACCAGCTGCAGGGATGAATCCTCAAGAAACAGCTGAATTAACTGAATTAATTCGTCAAATCAAAGAAGAGTTTAGTATTACTATTATGTTAATTGAACACGACATGAGTCTGGTTATGGATGTTACTGAACGTATTTATGTTTTGGAATACGGACGTCTCATTGCTCAGGGAACACCAGAAGAAATTAAGCACAACAAACGCGTAATTGAAGCTTATCTAGGAGGTGAAGCCTGA","4.90","-8.26","28271","MALLDVKNLTKNFGGLTAVGDVTLELNEGELVGLIGPNGAGKTTLFNLLTGVYEPSEGSVELDGTLLNGKTPYKIASLGLSRTFQNIRLFKNMTVIENVLVGMENTRNPHLFSSFLRLPSFYSNETDLQEKAIELLKIFNLDDKADTLAKNLPYGQQRRLEIVRALATKPKILFLDEPAAGMNPQETAELTELIRQIKEEFSITIMLIEHDMSLVMDVTERIYVLEYGRLIAQGTPEEIKHNKRVIEAYLGGEA","1582489","For other components see SMu1517 (NBD2); SMu1520 (MSD1); SMu1519 (MSD2) and SMu1521 (SBP1).For other 'liv' genes see SMu1517 (livF); SMu1519 (livM); SMu1520 (livH); SMu1521 (livK) and SMu1316 (livG).","branched chain amino acid ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Significant hits in gapped BLAST to branched-chain amino acid ABC transporter, ATP-binding proteins. Residues 1-254 are 83% similar to >gi|15900647 in S. pneumoniae. Residues 3-253 are 50% similar to >gi|15643895 in Thermotoga maritima.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1579 (1e-109).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[151-194]T$	ABC_transporter
PF00005	$\"[29-228]T$	ABC_tran
PS50893	$\"[4-252]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-228]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-251]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-107]T$ $\"[123-253]T$	PTHR19222
PTHR19222:SF14	$\"[4-107]T$ $\"[123-253]T$	PTHR19222:SF14
SSF52540	$\"[1-249]T$	SSF52540

","BeTs to 5 clades of COG0411COG name: High-affinity branched amino acid transport system ATPaseFunctional Class: EThe phylogenetic pattern of COG0411 is Am----vCe------------Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.4e-29. IPB001140A 18-64 IPB001140B 149-187 IPB001140C 205-234","Residues 79-149 are 52% similar to a (ATP-BINDING PROTEOME ACID COMPLETE) protein domain (PD019710) which is seen in Q9S2J2_STRCO.Residues 132-229 are 29% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 195-253 are 50% similar to a (ATP-BINDING TRANSPORT ABC COMPLETE) protein domain (PD284383) which is seen in Q9L3M5_RHILV.Residues 195-236 are 57% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9X0M2_THEMA.Residues 203-251 are 55% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER) protein domain (PD338129) which is seen in Q9HUQ3_PSEAE.Residues 19-69 are 56% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9X0M2_THEMA.Residues 151-194 are 72% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9RVJ3_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 08:29:50 2002","Fri Feb 1 13:47:36 2002","Thu Oct 17 08:29:50 2002","Wed Apr 10 14:42:53 2002","Fri Feb 1 13:47:36 2002","Fri Feb 1 13:47:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1518 is paralogously related (blast p-value < 1e-3) to branched chain amino acid ABC transporter, ATP-binding proteins: SMu1517, SMu0517, SMu0418, SMu0849, SMu0731, SMu1023, SMu1762, SMu1920, SMu1649, SMu0390, SMu1003, SMu0335, SMu0884, SMu1210, SMu1079, SMu0950, SMu1410, SMu0235, SMu0218, SMu0596, SMu0971, SMu0944, SMu1949, SMu1380, SMu1950, SMu0374, SMu0907, SMu1316, SMu1428, SMu0805, SMu1068, SMu0216, SMu1246, SMu1231, SMu1545, SMu1093, SMu0594, SMu0916, SMu0786, SMu1288, SMu1001, SMu1064, SMu0976, SMu0234, SMu1050, SMu1036, SMu0164, SMu0258, SMu1037, SMu1757, SMu1710, SMu0836, SMu0825, SMu0823, SMu1751, SMu0986, SMu1959, SMu0476, SMu0666, SMu0837, SMu0824, SMu0224, SMu1811, SMu1065, SMu0987, SMu0752, SMu0475, SMu1306, SMu1724, SMu0024, SMu0729, and SMu1686, all ATP-binding proteins.","Tue Feb 26 12:45:01 2002","Fri Feb 1 13:47:36 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 115 6e-027pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 108 1e-024","SMU.1666c","","Residues 29 to 228 (E-value = 4.5e-59) place SMu1518 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Feb 1 13:47:36 2002","","","","","","","1","","","SMU.1666c","437" "SMu1519","1584193","1583237","957","ATGAAAAAAAATTTAAAAGCAAATATAACTTGGCTTGCCCTAGTCCTTATCATCTTTTTTCTTCTTTTTGGACTTATTAGTGCTGGTATCATAGATATTTACTATACTCAAATTCTCATGGGAATTGGGATTAGTATTATCATGGCACTCGGAACCAACTTAGTTCTTGGCTTTTCTGGACAGCTCTCTCTTGGACAAGCTGGCTTTATGGCCATTGGTGCTTATGCAACTGCTATTTTAACAACTCAAAATCCTACTTATGCAGGTTTCTATTTATCCATTATTGTCGGTATGATAGTGACTGCAACGGTTGCCTTGGTTGTTGGGATTCCAACACTTCGTTTGAAGGGTGATTACTTAGCTATTGCAACTCTTGGTGTAGCTGAAATTATCCGTAAACTGATTGAAAATGGTGGTGATTTGACTAATGGTTCTAGGGGAATTATGGGAATTCTCAAATACACCACTTGGCCAGTCGTCTTTGTTTTCGTTGTTTTGATTACCATTTTTGTGTTAAATTATCTGAGGAGTCCTATGGGAAGAGAAGTACTTGCGGTTCGTGAAGATGAAATTGCAGCAGAAGCTATGGGGGTGAATACGACAAAAATTAAGGTACTTACTTTTATGATTGCTGCAGTAATTTCCAGCATTGCAGGTTCCCTTTATGTCGGTTATATTGGTACAGTCGCTCCTAAAGATTTTACCATTATGAAATCAATTGATTTTCTTATCGTGGCTGTTCTTGGTGGACTTGGCTCAGTAACAGGAACTATTGTGGCTGCTGTTGTTTTGGGTATCCTCAATATGTTCTTGCAAAATGTATCAGATATTCGTATGATTATCTATTCGTTAGCTTTAATTTTGGTTATGGTCTTTAGACCAGGCGGTCTTTTAGGAACATGGGAATTCAGTTTTTCAAGACTTTTCGCTAAAAAAGCTAAGGAGGGCGACAAATAA","10.40","6.99","34057","MKKNLKANITWLALVLIIFFLLFGLISAGIIDIYYTQILMGIGISIIMALGTNLVLGFSGQLSLGQAGFMAIGAYATAILTTQNPTYAGFYLSIIVGMIVTATVALVVGIPTLRLKGDYLAIATLGVAEIIRKLIENGGDLTNGSRGIMGILKYTTWPVVFVFVVLITIFVLNYLRSPMGREVLAVREDEIAAEAMGVNTTKIKVLTFMIAAVISSIAGSLYVGYIGTVAPKDFTIMKSIDFLIVAVLGGLGSVTGTIVAAVVLGILNMFLQNVSDIRMIIYSLALILVMVFRPGGLLGTWEFSFSRLFAKKAKEGDK","1583253","For other components see SMu1518 (NBD1); SMu1517 (NBD2); SMu1520 (MSD1) and SMu1521 (SBP1).For other 'liv' genes see SMu1517 (livF); SMu1518 (livG); SMu1520 (livH); SMu1521 (livK) and SMu1316 (livG).","branched chain amino acid ABC transporter, permease","Membrane, Cytoplasm","Significant hits in gapped BLAST to branched-chain amino acid ABC transporter, permease protein. Residues 1-315 are 58% similar to >gi15900646 in S. pneumoniae. Residues 32-312 are 34% similar to >gi15643894 in Thermotoga maritima.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1580 (1e-101).","

InterPro
IPR001851
Family

Bacterial inner-membrane translocator
PF02653	$\"[34-290]T$	BPD_transp_2

","BeTs to 5 clades of COG0559COG name: Branched-chain amino acid ABC-type transport system, permease componentsFunctional Class: EThe phylogenetic pattern of COG0559 is AM----VCE------------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 44-264 are 36% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000838) which is seen in LIVM_SALTY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 16:20:17 2006","Thu Sep 14 16:20:17 2006","Thu Sep 14 16:20:17 2006","Wed Apr 10 14:53:30 2002","","Fri Feb 1 13:52:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1519 is paralogously related (blast p-value < 1e-3) to predicted branched chain amino acid ABC transporter, permease proteins: SMu1520, SMu1021, SMu0119, and SMu0643.","Fri Feb 1 13:53:42 2002","","No significant hits to the NCBI PDB database.","SMU.1667c","","Residues 34 to 290 (E-value = 5.9e-44) place SMu1519 in the BPD_transp_2 family which is described as Branched-chain amino acid transport system / permease component (PF02653)","Fri Feb 1 13:52:22 2002","","","","","","","1","","","SMU.1667c","438" "SMu1520","1585066","1584197","870","ATGCTCCAACAACTTATTAATGGTCTTATCCTAGGGAGTGTCTATGCTCTGTTAGCCCTTGGTTATACCATGGTTTATGGAATTATTAAGTTAATTAACTTTGCCCATGGAGATATTTATATGATGGGAGCCTTTATTGGTTATTTTCTTATTACAAAATATCATATGAATTTCTTTGTGGCTCTTGTGCTGACGATGGTCTTAACAGCTATCTTAGGGGTTGTGATTGAATTTCTGGCTTATCGTCCTTTGCGGAATTCGACACGTATCGCTGCTTTGATTACTGCCATTGGTGTTTCTTTTTTTCTCGAATACAGTATGGTTCGTTTAGTTGGTGCCAATAAACATGCTTTTCCCCAAACCCTTGCTACAGTGAAATATAATTTAGGTCCTGTTAGTGTAACCAATGTACAACTCATCATTTTAGGAGTCTCTATCTTCTTGATGTTGGCTTTGCAGTTTATTGTCCAAAAAACTAAAATGGGTAAAGCCATGCGTGCCGTTTCAGTTGACAGTGATGCTGCGCAGTTAATGGGAATCAATGTTAATAGTACTATTAGTTTTACCTTTGCTTTAGGTTCTGCACTTGCTGGTGCTGGTGGTGTCTTGATTGGACTTTATTATAATTCTGTTGATCCACTGATGGGAATGGTTCCCGGTATTAAAGCCTTTGTCGCCGCTGTTTTAGGCGGTATTGGTATTATTCCAGGTGCAGCTGTCGGGGGCTTTATGATTGGTCTTTTAGAGACGTTTTCTGTTTCTATCGGTCTTGCAAGTTACAAGGATGCAGTTGTCTATGCAGTGCTTATCATTATCCTTTTAGTAAGACCAGCTGGTATTTTAGGAAAAAATGTGAAAGAGAAGGTGTAA","10.50","9.70","30701","MLQQLINGLILGSVYALLALGYTMVYGIIKLINFAHGDIYMMGAFIGYFLITKYHMNFFVALVLTMVLTAILGVVIEFLAYRPLRNSTRIAALITAIGVSFFLEYSMVRLVGANKHAFPQTLATVKYNLGPVSVTNVQLIILGVSIFLMLALQFIVQKTKMGKAMRAVSVDSDAAQLMGINVNSTISFTFALGSALAGAGGVLIGLYYNSVDPLMGMVPGIKAFVAAVLGGIGIIPGAAVGGFMIGLLETFSVSIGLASYKDAVVYAVLIIILLVRPAGILGKNVKEKV","1584213","For other components see SMu1518 (NBD1); SMu1517 (NBD2); SMu1519 (MSD2) and SMu1521 (SBP1).For other 'liv' genes see SMu1517 (livF); SMu1518 (livG); SMu1519 (livM); SMu1521 (livK) and SMu1316 (livG).","branched chain amino acid ABC transporter, permease","Membrane, Cytoplasm","Significant hits in gapped BLAST to ABC transporter membrane-spanning permease. Residues 1-289 are 66% similar to gi15902704 in S. pneumoniae. Residues 1-289 are 66% similar to gi15900645 in S. pneumoniae. Residues 2-289 are 35% similar to gi15643893 in Thermotoga maritima.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1581 (1e-103).","

InterPro
IPR001851
Family

Bacterial inner-membrane translocator
PF02653	$\"[4-273]T$	BPD_transp_2

InterPro
IPR001991
Family

Sodium:dicarboxylate symporter
PR00173	$\"[1-20]T$ $\"[47-72]T$ $\"[177-199]T$	EDTRNSPORT

","BeTs to 5 clades of COG0559COG name: Branched-chain amino acid ABC-type transport system, permease componentsFunctional Class: EThe phylogenetic pattern of COG0559 is AM----VCE------------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 2-251 are 37% similar to a (PERMEASE TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000838) which is seen in Q9X0M0_THEMA.Residues 5-117 are 25% similar to a (PROTEOME 294AA AMINO COMPLETE) protein domain (PD337872) which is seen in Q9YCF2_AERPE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 16:23:08 2006","Thu Sep 14 16:23:08 2006","Thu Sep 14 16:23:08 2006","Wed Apr 10 14:43:56 2002","","Fri Feb 1 13:57:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1520 is paralogously related (blast p-value < 1e-3) to SMu1519, SMu1317, SMu1021, and SMu1022, all predicted ABC transporter permeases.","Tue Feb 26 12:49:38 2002","","No significant hits to the NCBI PDB database.","SMU.1668c","","Residues 4 to 273 (E-value = 7.3e-44) place SMu1520 in the BPD_transp_2 family which is described as Branched-chain amino acid transport system / permease component (PF02653)","Fri Feb 1 13:57:09 2002","","","","","","","1","","","SMU.1668c","439" "SMu1521","1586322","1585150","1173","ATGAAGAAAAAAATAGCTCTAGCAGCTCTTTCTTTTGTCAGTGCAGCTGTTCTTGCAGCTTGCAGCTCAGCACCTGGTGGTTCATCAGATGCAGCTGGTAATAAAATTGGAGATACTGTAAAAATTGGTTACAATCTTGAATTATCAGGAGATGTAGCCGCTTATGGACAAGCTGAAAAGAACGGTGCTAACCTTGCTGTTGAAGAGATTAATAAGGCAGGCGGCATTGATGGCAAAAAGATTAAAGTTATCTCAAAAGATAATAAATCTGATAACGGTGAAGCATCAACAATCTCAACTAATCTTGCTACCCAAAGTAAAGTAAATGCTATCTTGGGACCAGCAACATCTGGTGCTACAGCGGCTGCTGCTCCCAATGCCAACGATGCTGCAGTACCACTCGTAACGCCTTCTGGAACACAAGATAATTTGACCTATTCAAAAGGCAAAGTTCAAGATTACATCTTCCGTACAACTTTTCAAGATAGCTTCCAAGGAAAGATCATTGCCAAATATGCAACAGATAATTTGAAAGCTAAAAAAGTAGCGCTTTACTATGATAAGTCAAGTGATTACGCCCAAGGTATTGCTGATGCATTCAAAAAAGCATATAAAGGGAAGATTACTGTTGAAGATACCTTTCAAGCTAAAGACCAAGATTTCCAAGCAGCTCTGACCAAGTTTAAAAATAAAGACTTTGATGCCATTGTGATACCAGGTTATTATACTGAAACTGGTCTGATTACAAAGCAAGCACGTGATATGGGGCTTACCCAGCCTATCTTAGGACCTGATGGTTTTAATGATGAAAAATATGTTGAAGGTGCTGGTGCAGCCAATACCAATAATGTTCATTATGTATCTGGTTACTCAACAAAAGTTGCTTTAACAAATAAGGCTGAAAAATTCCTGAAAGATTATAAGGCTAAGTATGGTGAAGAGCCAAATATGTTTGCCGCTCTTGCTTATGATTCCGTTTATATGATTGCTGATGCTGCAAAAGATGCCAAAACATCTAAGGATATTGCAACAAACCTAGCTAAATTGAAAAACTTTAAAGGTGTGACAGGTAAAATGACAATTGATAAGAAACATAACCCTGTTAAATCAGCCGTTATGGTTGGTCTTAAAGATGGTAAAGAAGACACAGCTACTGCTGTTGAAGCAAAATAA","9.80","8.45","41205","MKKKIALAALSFVSAAVLAACSSAPGGSSDAAGNKIGDTVKIGYNLELSGDVAAYGQAEKNGANLAVEEINKAGGIDGKKIKVISKDNKSDNGEASTISTNLATQSKVNAILGPATSGATAAAAPNANDAAVPLVTPSGTQDNLTYSKGKVQDYIFRTTFQDSFQGKIIAKYATDNLKAKKVALYYDKSSDYAQGIADAFKKAYKGKITVEDTFQAKDQDFQAALTKFKNKDFDAIVIPGYYTETGLITKQARDMGLTQPILGPDGFNDEKYVEGAGAANTNNVHYVSGYSTKVALTNKAEKFLKDYKAKYGEEPNMFAALAYDSVYMIADAAKDAKTSKDIATNLAKLKNFKGVTGKMTIDKKHNPVKSAVMVGLKDGKEDTATAVEAK","1585166","For other components see SMu1518 (NBD1); SMu1517 (NBD2); SMu1520 (MSD1) and SMu1519 (MSD2).For other 'liv' genes see SMu1517 (livF); SMu1518 (livG); SMu1519 (livM); SMu1520 (livH) and SMu1316 (livG).","branched-chain amino acid ABC transporter, substrate-binding protein","Extracellular, Periplasm, Membrane","Significant hits in gapped BLAST to branched-chain amino acid ABC transporter, amino acid-binding protein. Residues 39-388 are 52% similar to >gi15900644 in S. pneumoniae. Residues 40-382 are 30% similar to >gi15643892 in Thermotoga maritima.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1582 (1e-107).","

InterPro
IPR000709
Family

Leu/Ile/Val-binding protein
PR00337	$\"[40-56]T$ $\"[62-78]T$	LEUILEVALBP

InterPro
IPR001828
Domain

Extracellular ligand-binding receptor
PF01094	$\"[58-379]T$	ANF_receptor

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.9600	$\"[38-228]T$	G3DSA:3.40.50.9600
PS51257	$\"[1-21]T$	PROKAR_LIPOPROTEIN
SSF53822	$\"[38-383]T$	SSF53822

","BeTs to 5 clades of COG0683COG name: Periplasmic leucine/isoleucine/valine-binding proteinFunctional Class: EThe phylogenetic pattern of COG0683 is Am----vCE------------Number of proteins in this genome belonging to this COG is 1","***** PR00337 (Leu/Ile/Val-binding protein family signature) with a combined E-value of 3.5e-07. PR00337A 40-56 PR00337B 62-78","Residues 133-380 are 22% similar to a (BINDING SUBSTRATE ABC TRANSPORTER) protein domain (PD110260) which is seen in O07470_RHOPA.Residues 39-111 are 39% similar to a (PROTEOME BINDING COMPLETE PERIPLASMIC) protein domain (PD003345) which is seen in Q9RYJ2_DEIRA.Residues 180-325 are 36% similar to a (PERIPLASMIC BINDING AMINO TRANSPORT) protein domain (PD126366) which is seen in Q9X0L9_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 16:27:53 2006","Thu Sep 14 16:27:53 2006","Thu Sep 14 16:27:53 2006","Wed Apr 10 14:54:33 2002","Tue Feb 5 19:34:12 2002","Tue Feb 5 19:34:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1521 is paralogously related (blast p-value < 1e-3) to SMu1318, a conserved hypothetical protein.","Tue Feb 26 12:50:50 2002","Thu Sep 14 16:27:53 2006","pdb2LBP Leucine-Binding Protein (LBP) 111 1e-025pdb2LIV Leucine(Slash)Isoleucine(Slash)Valine-Binding Prot... 109 4e-025","SMU.1669c","","Residues 58 to 380 (E-value = 1.9e-48) place SMu1521 in the ANF_receptor family which is described as Receptor family ligand binding region (PF01094)","Tue Feb 5 19:34:12 2002","","","","","","","1","","","SMU.1669c","440" "SMu1522","1586673","1586425","249","ATGTTTGAAAAGAAAAAAAGACTAGGTCTTATTGTTTATCTTTATTATAATCGTGATGCCAGAAAGCTTAATAAGTATGGCAACGTCGTTTACCATTCTCGGCGAATGCGTTATTCAGTACTCTATATTGCTCAAGACGAAACTGATAAAATTATTGAAGAGATTGGTGCTCTTAAATTTGTCAAAAAGGTTCTTCCATCCTATATTGATACGATTGATCAAAATTTTGTAGGCAGTTTAATGCGCTAA","10.60","7.22","9811","MFEKKKRLGLIVYLYYNRDARKLNKYGNVVYHSRRMRYSVLYIAQDETDKIIEEIGALKFVKKVLPSYIDTIDQNFVGSLMR","1586441","","conserved hypothetical protein","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-82 are 54% similar to >gi|15674538 in S. pyogenes. Residues 1-82 are 47% similar to >gi|15900643 in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1583 (6e-23).","

noIPR
unintegrated

unintegrated
PD585961	$\"[4-82]T$	PD585961

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-80 are 38% similar to a (PROTEOME COMPLETE BH2594 YLBG) protein domain (PD063413) which is seen in O34658_BACSU.Residues 5-76 are 40% similar to a (PROTEOME COMPLETE YDGE) protein domain (PD394961) which is seen in Q9CIJ9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 08:01:04 2002","Tue Feb 5 19:47:39 2002","Wed Oct 9 08:01:04 2002","Tue Feb 5 19:47:39 2002","","Tue Feb 5 19:47:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1522 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 08:01:04 2002","","No significant hits to the NCBI PDB database.","SMU.1670c","","No significant hits to the Pfam 11.0 database","Tue Feb 5 19:47:39 2002","24380048","","","","","","1","","","SMU.1670c","1021" "SMu1523","1587120","1586680","441","ATGTTAAAAATTAACAGTCAATTATTTGCAATTGAAGATACTCTTGATGATCTTGCGGCTGCTTTTTTAAATTTGGAGGTGGTCAGGACGTACAAGGCAGCTCAAAAAGCATTTTTAGCTGATAAACATTTGCAAAAAGAAATTAGTAATTTTCAACATTATAATGAAGATTACAATGATCAAAAAACTTTTATTAAATACCGTCCGGAAGTAAAGCAATTGAGGCGAAAGATATTTGAAAAAAAACGTCAGCTTGATTTGAACGAAAAAGTTATTGCACTTCGCAGAGCCGAAGTGGATTTACAGGAAGTTCTAGCTAAGATTGCTCAAAAAATAGCAGAATCTGTTTCATCTGATGTTTTTGTAGATACGGGTTTACCGCTGGCACCGCATAAACCACCTCACAAAAAAGGATATGGCAATAATATTAAGGAAAGATAA","10.10","5.96","16934","MLKINSQLFAIEDTLDDLAAAFLNLEVVRTYKAAQKAFLADKHLQKEISNFQHYNEDYNDQKTFIKYRPEVKQLRRKIFEKKRQLDLNEKVIALRRAEVDLQEVLAKIAQKIAESVSSDVFVDTGLPLAPHKPPHKKGYGNNIKER","1586696","","conserved hypothetical protein","Cytoplasm","Significant hits in gapped BLAST to unknown proteins. Residues 10-127 are 39% similar to >gi|16804094 in Listeria monocytogenes. Residues 10-127 are 36% similar to >gi|16801227 in L. innocua.SMu1523 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR009763
Family

Protein of unknown function DUF1333
PF07050	$\"[1-143]T$	DUF1333

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 11-127 are 35% similar to a (PROTEOME COMPLETE BH2596 YLBF) protein domain (PD415292) which is seen in O34412_BACSU.Residues 1-128 are 35% similar to a (PROTEOME COMPLETE YDGD) protein domain (PD396767) which is seen in Q9CIK0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 12:54:39 2002","Tue Feb 5 19:54:26 2002","Tue Feb 26 12:54:39 2002","Tue Feb 5 19:54:26 2002","","Tue Feb 5 19:54:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1523 is paralogously related (blast p-value < 1e-3) to SMu1164, a predicted histidyl-tRNA synthetase.","Tue Feb 26 12:54:39 2002","","No significant hits to the NCBI PDB database.","SMU.1671c","","Residues 1 to 143 (E-value = 8.2e-87) place SMu1523 in the DUF1333 family which is described as Protein of unknown function (DUF1333) (PF07050)","Tue Feb 5 19:54:26 2002","24380049","","","","","","1","","","SMU.1671c","" "SMu1524","1587826","1587236","591","ATGATTCCTGTAGTTATTGAACAAACGAGCCGTGGTGAACGCTCTTATGATATTTATTCACGTCTATTAAAAGATCGTATTATTATGTTGACTGGTCCTGTTGAAGACAATATGGCAAATTCCATTATTGCTCAGTTACTGTTTCTTGATGCACAAGATAATACCAAAGACATTTATCTTTATATTAATTCACCGGGTGGTTCTGTTTCAGCTGGTCTTGCTATTGTTGATACGATGAACTTTATTAAGTCTGATGTTCAAACGATTGTTATGGGTATTGCTGCTTCCATGGGAACAATCATCGCTTCTAGCGGTGCCAAAGGAAAACGTTTTATGTTACCAAATGCAGAATATCTTATCCATCAGCCAATGGGCGGTACAGGCGGTGGCACACAGCAGTCTGATATGGCTATTGCTGCCGAACAATTGCTTAAAACACGCAAAAAATTAGAAAAGATTCTATCGGATAATTCTGGAAAAACAATAAAACAAATTCATAAGGATGCTGAACGTGATTATTGGATGGATGCTAAGGAAACATTAAAGTATGGCTTCATCGATGAAATCATGGAAAATAATGAATTAAAATAA","5.40","-2.52","21655","MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYINSPGGSVSAGLAIVDTMNFIKSDVQTIVMGIAASMGTIIASSGAKGKRFMLPNAEYLIHQPMGGTGGGTQQSDMAIAAEQLLKTRKKLEKILSDNSGKTIKQIHKDAERDYWMDAKETLKYGFIDEIMENNELK","1587252","For other 'clp' genes see SMu0511 (clpE); SMu0861 (clpX) ; SMu0868 (clpE), (clpL); SMu1844 (clpC) and SMu1300 (clpB).For ATP-dependent Clp protease subunit X see SMu0861. For ATP-dependent Clp protease, ATP-binding subunit see SMu0868. For ATP-dependent Clp protease,ATP-binding subunit ClpB see SMu1300. For ATP-dependent Clp protease, ATP-binding subunit see SMu1844. ","ATP-dependent Clp protease, proteolytic subunit","Cytoplasm, Membrane","Significant hits in gapped BLAST to ATP-dependent protease proteolytic subunit. Residues 1-198 are 86% similar to >gi15674537 as seen in S. pyogenes. Residues 1-196 are 83% similar to >gi15672655 as seen in L. lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1585 (2e-90).","

InterPro
IPR001907
Family

Peptidase S14, ClpP
PR00127	$\"[17-32]T$ $\"[57-77]T$ $\"[88-105]T$ $\"[109-128]T$ $\"[168-187]T$	CLPPROTEASEP
PTHR10381	$\"[54-195]T$	Pept_S14_ClpP
PF00574	$\"[10-193]T$	CLP_protease
PS00381	$\"[88-99]T$	CLP_PROTEASE_SER
PS00382	$\"[110-123]T$	CLP_PROTEASE_HIS

noIPR
unintegrated

unintegrated
G3DSA:3.90.226.10	$\"[1-194]T$	G3DSA:3.90.226.10
SSF52096	$\"[10-194]T$	SSF52096

","BeTs to 11 clades of COG0740COG name: Protease subunits of ATP-dependent proteases, ClpP familyFunctional Class: OThe phylogenetic pattern of COG0740 is -----qvCebRhuj--OLINxNumber of proteins in this genome belonging to this COG is 1","***** IPB001907 (Clp protease) with a combined E-value of 1.5e-96. IPB001907A 2-26 IPB001907B 42-87 IPB001907C 88-126 IPB001907D 146-189","Residues 2-192 are 84% similar to a (PROTEASE ATP-DEPENDENT PROTEOLYTIC HYDROLASE) protein domain (PD001650) which is seen in Q9CHQ3_LACLA.Residues 52-123 are 34% similar to a (PROTEASE CLPP-LIKE AUTOCATALYTIC CLEAVAGE) protein domain (PD134274) which is seen in CLPP_CHLEU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 14:25:06 2006","Tue Feb 5 19:55:11 2002","Thu Aug 31 14:25:06 2006","Tue Apr 2 08:43:52 2002","Tue Feb 5 19:55:11 2002","Tue Feb 5 19:55:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1524 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 20:13:07 2002","Thu Aug 31 14:25:06 2006","pdb1TYFA Chain A, The Structure Of Clpp At 2.3 Angstrom Resol... 217 8e-058","SMU.1672c","","Residues 10 to 193 (E-value = 1.6e-116) place SMu1524 in the CLP_protease family which is described as Clp protease (PF00574)","Tue Feb 5 19:55:11 2002","","","Lemos JA, Burne RA. Regulation and Physiological Significance of ClpC and ClpP in Streptococcusmutans.J Bacteriol. 2002 Nov 15;184(22):6357-6366.PMID: 12399506 ","Pummi T, Leskela S, Wahlstrom E, Gerth U, Tjalsma H, Hecker M, Sarvas M, Kontinen VP.ClpXP Protease Regulates the Signal Peptide Cleavage of Secretory Preproteins in Bacillus subtilis with a Mechanism Distinct from That of the Ecs ABC Transporter.J Bacteriol. 2002 Feb 15;184(4):1010-1018.PMID: 11807061Steiner K, Malke H.relA-Independent amino acid starvation response network of Streptococcus pyogenes.J Bacteriol. 2001 Dec;183(24):7354-64.PMID: 11717294Chastanet A, Prudhomme M, Claverys JP, Msadek T.Regulation of Streptococcus pneumoniae clp genes and their role in competence development and stress survival.J Bacteriol. 2001 Dec;183(24):7295-307.PMID: 11717289Nakano MM, Hajarizadeh F, Zhu Y, Zuber P.Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis.Mol Microbiol. 2001 Oct;42(2):383-94.PMID: 11703662","Sat Oct 26 16:15:47 2002","Tue Feb 5 20:13:07 2002","1","","","SMU.1672c","592" "SMu1525","1588987","1588358","630","ATGGGGAAATTTCAAATCATTTCGCATCCGCTCATTCAGCACAAACTCTCTATTTTACGTCGTAAAGATACTTCAACAAAGCATTTTCGTGAATTAGTCAATGAAATTGCTATGCTTATGGGGTATGAAGTCTCCCGTGAATTGCCGCTAGAAGAGGTTGAGATTGAAACGCCGATTACTAAGACTGTACAAAAACAGTTGACAGGAAAGAAATTGGCCATTGTTCCAATTTTGCGTGCTGGTATTGGTATGGTTGACGGACTCTTGAGTTTGGTACCAGCAGCTAAAGTTGGTCATATTGGTATGTATCGTGATGAAGAAACATTGGAGCCGGTAGAATATCTGGTTAAATTACCTGAAGATATTGACCAACGTCAGATTTTTGTGGTTGATCCCATGTTAGCAACTGGAGGTTCGGCTGTCTTGGCTATTGATTCCCTTAAAAAAAGAGGAGCAGCCAATATCAAATTTGTTTGTCTTGTTTCGGCTCCTGAAGGCCTTAAGAAATTACAGGAAGCACATCCCGATATTGATATTTATACAGCGGCTCTTGATGAAAAACTAAATGAAAAGGGCTATATTGTTCCAGGTCTTGGGGATGCAGGCGATCGCTTGTTTGGCACAAAATAA","6.70","-0.84","23036","MGKFQIISHPLIQHKLSILRRKDTSTKHFRELVNEIAMLMGYEVSRELPLEEVEIETPITKTVQKQLTGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRDEETLEPVEYLVKLPEDIDQRQIFVVDPMLATGGSAVLAIDSLKKRGAANIKFVCLVSAPEGLKKLQEAHPDIDIYTAALDEKLNEKGYIVPGLGDAGDRLFGTK","1588374","For other 'upp' genes see SMu1626 (uppS). ","uracil phosphoribosyltransferase","Cytoplasm","Significant hits in gapped BLAST to uracil phosphoribosyltransferase. Residues 1-209 are 93% similar to >gi|549167 as seen in Streptococcus salivarius. Residues 1-209 are 89% similar to >gi|15902699 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1586 (1e-105).","

InterPro
IPR000836
Domain

Phosphoribosyltransferase
PF00156	$\"[46-180]T$	Pribosyltran

InterPro
IPR005765
Family

Uracil phosphoribosyl transferase
TIGR01091	$\"[3-209]T$	upp

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2020	$\"[5-209]T$	G3DSA:3.40.50.2020
PTHR10285	$\"[6-208]T$	PTHR10285
PTHR10285:SF1	$\"[6-208]T$	PTHR10285:SF1
SSF53271	$\"[4-209]T$	SSF53271

","BeTs to 10 clades of COG0035COG name: Uracil phosphoribosyltransferaseFunctional Class: FThe phylogenetic pattern of COG0035 is --t-Yqvcebrh--gp-l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-207 are 93% similar to a (URACIL PHOSPHORIBOSYLTRANSFERASE) protein domain (PD003612) which is seen in UPP_STRSL.Residues 104-207 are 35% similar to a (GLYCOSYLTRANSFERASE URACIL UMP UPRTASE) protein domain (PD183421) which is seen in UPP_TREPA.Residues 2-107 are 36% similar to a (PROTEOME COMPLETE VNG2305C) protein domain (PD295059) which is seen in Q9HN05_HALN1.Residues 75-184 are 32% similar to a (URIDINE KINASE MONOPHOSPHOKINASE CG5537) protein domain (PD075526) which is seen in Q9LFZ2_ARATH.Residues 3-185 are 24% similar to a (YCF19-YCF17 CHLOROPLAST ORF198) protein domain (PD075529) which is seen in YCXL_PORPU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 08:22:56 2002","Tue Feb 5 20:09:29 2002","Thu Oct 17 08:22:56 2002","Thu Apr 11 11:11:36 2002","","Tue Feb 5 20:09:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1525 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 5 21:27:02 2002","Tue Feb 5 20:09:29 2002","pdb|1UPF|A Chain A, Structure Of The Uracil Phosphoribosyltrans... 129 2e-031pdb|1BD3|A Chain A, Structure Of The Apo Uracil Phosphoribosylt... 129 2e-031","SMU.1673c","","Residues 46 to 180 (E-value = 2.3e-14) place SMu1525 in the Pribosyltran family which is described as Phosphoribosyl transferase domain (PF00156)","Tue Feb 5 20:09:29 2002","","","","Coppee JY, Auger S, Turlin E, Sekowska A, Le Caer JP, Labas V, Vagner V, Danchin A, Martin-Verstraete I.Sulfur-limitation-regulated proteins in Bacillus subtilis: a two-dimensional gel electrophoresis study.Microbiology. 2001 Jun;147(Pt 6):1631-40.PMID: 11390694 Fujihashi M, Zhang YW, Higuchi Y, Li XY, Koyama T, Miki K.Crystal structure of cis-prenyl chain elongating enzyme, undecaprenyl diphosphate synthase.Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4337-42.PMID: 11287651","","Tue Feb 5 20:09:29 2002","1","","","SMU.1673c","441" "SMu1526","1590463","1589300","1164","ATGGGACGATATGATTTTACAACAAGACCTGACCGTCTTAACCAATTTACCTATAAGTGGAAAACTTCTGAAAATAATCCAGAGCTTCTCCAGATGTGGGTGGCTGATATGGACTTTTTGCCTGTACCAGAAATTAAAGAAGCTATTATTAATTATGGACGAGAACATATTTTTGGTTATAACTATTTTAACGATGACCTCTATCAAGCGGTTATTGATTGGGAAAGAAAGGAGCATGACTATGCTGTTGTAAAAGAAGATATTCTTTTCATTGATGGCGTTGTTCCAGCCATTTCAATAGCTCTGCAGGCTTTTAGTGAAAAAGGAGATGCTGTTTTAATTAACTCACCCGTCTATTATCCTTTCGCACGTACAATCAGACTAAATGACCATCGGTTGGTAGAAAATTCTCTTCAAATTATTAATGGACGTTTCGAGATTGATTTTGAACAGCTGGAGAAAGATATTATTGACAATAATGTCAAAATTTATCTTCTTTGCAGTCCTCATAATCCTGGTGGGCGTGTTTGGGATAATGATGATTTGATCAAAATAGCTGAGCTTTGCAAGAAGCATGGTGTGATTTTAGTTTCTGATGAAATTCATCAGGATTTGGCTCTTTTTGGAAATACACATCATTCCCTCAACACTTTAGATGCTTCATACAAGGATTTTACGATTATTCTAAGTTCAGCAACTAAAACTTTTAATATTGCAGGAACTAAAAACAGCTTTGCTATTATTCAAAATGAGAGTTTGCGTCGAAAATTTCAATATAGGCAGTTGGCTAACAATCAGCATGAAGTGCCAACCGTTGGGATGATAGCAACTCAAGCGGCCTTCCAATATGGAAAACCTTGGTTGGAAGAGCTCAAAACAGTTATTGAGGGAAATATTAAACTGGTCATAAAGGAATTAGAAGCAAAAACGAAAATCAAAGTGATGGAACCTGAAGGTACTTATTTGGTTTGGCTGGATTTTTCTGCTTATGCTATTGCTCAGCCTCAACTGAGTGAAAAACTGCAAAATGAAGCAAAAGTTGTCCTCAATGATGGTGCACACTTCGGTAAGGAAGGCAAGTACTTTGCTCGTCTTAATGTTGCGACACCTAAGAATACAGTTCAAGAAGCACTAAGTCGCATTATCAGTGTCTTTGGAAAATAA","5.90","-6.66","44385","MGRYDFTTRPDRLNQFTYKWKTSENNPELLQMWVADMDFLPVPEIKEAIINYGREHIFGYNYFNDDLYQAVIDWERKEHDYAVVKEDILFIDGVVPAISIALQAFSEKGDAVLINSPVYYPFARTIRLNDHRLVENSLQIINGRFEIDFEQLEKDIIDNNVKIYLLCSPHNPGGRVWDNDDLIKIAELCKKHGVILVSDEIHQDLALFGNTHHSLNTLDASYKDFTIILSSATKTFNIAGTKNSFAIIQNESLRRKFQYRQLANNQHEVPTVGMIATQAAFQYGKPWLEELKTVIEGNIKLVIKELEAKTKIKVMEPEGTYLVWLDFSAYAIAQPQLSEKLQNEAKVVLNDGAHFGKEGKYFARLNVATPKNTVQEALSRIISVFGK","1589316","","aminotransferase class II","Cytoplasm","Significant hits in gapped BLAST to aminotransferase class II proteins. Residues 1-387 are 56% similar to >gi|15901370 and >gi|15903419 as seen in S. pneumoniae. Residues 1-385 are 52% similar to >gi|15673898 as seen in L. lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1587 (1e-134).","

InterPro
IPR001176
Family

1-aminocyclopropane-1-carboxylate synthase
PR00753	$\"[109-130]T$ $\"[158-182]T$ $\"[194-217]T$	ACCSYNTHASE

InterPro
IPR004839
Domain

Aminotransferase, class I and II
PF00155	$\"[27-381]T$	Aminotran_1_2

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[41-284]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[2-387]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[44-385]T$	PTHR11751
PTHR11751:SF21	$\"[44-385]T$	PTHR11751:SF21

","BeTs to 3 clades of COG1168COG name: PLP-dependent aminotransferases, MalY/PatB familyFunctional Class: EThe phylogenetic pattern of COG1168 is --------ebRh---------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 100-202 are 60% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9CEC7_LACLA.Residues 110-204 are 28% similar to a (AMINOTRANSFERASE TRANSAMINASE ALANINE) protein domain (PD358273) which is seen in ALAT_SCHPO.Residues 5-95 are 42% similar to a (AMINOTRANSFERASE PROTEOME COMPLETE) protein domain (PD090053) which is seen in Q9CEC7_LACLA.Residues 102-242 are 33% similar to a (TRANSFERASE) protein domain (PD306460) which is seen in Q9EWU0_STRCO.Residues 271-339 are 55% similar to a (AMINOTRANSFERASE COMPLETE PROTEOME) protein domain (PD021947) which is seen in Q9CEC7_LACLA.Residues 204-257 are 57% similar to a (AMINOTRANSFERASE COMPLETE PROTEOME B) protein domain (PD351158) which is seen in Q9CEC7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 5 20:20:33 2002","Tue Feb 26 13:14:02 2002","Thu Oct 17 08:21:46 2002","Thu Oct 17 08:21:46 2002","","Tue Feb 5 20:17:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1526 is paralogously related (blast p-value < 1e-3) to aminotransferases: SMu0020, SMu1199, SMu1663, and SMu0740.","Tue Feb 5 20:20:33 2002","Tue Feb 5 20:17:17 2002","pdb|1C7N|A Chain A, Crystal Structure Of Cystalysin From Trepon... 237 2e-063pdb|1D2F|B Chain B, X-Ray Structure Of Maly From Escherichia Co... 189 7e-049pdb|1BKG|A Chain A, Aspartate Aminotransferase From Thermus The... 87 5e-018","SMU.1674c","","Residues 80 to 385 (E-value = 3.3e-12) place SMu1526 in the Aminotran_1_2 family which is described as Aminotransferase class I and II (PF00155)","Tue Feb 5 20:17:17 2002","","","","","","Tue Feb 26 13:10:45 2002","1","","","SMU.1674c","442" "SMu1527","1591572","1590478","1095","ATGACTGAAGACTATAAATTAGATACTATTCTGGCACATGCAGGAATTAATACGGACAAGACAACAGGAGCTCTGACGGCTCCTATTCATTTGTCAACAACTTATCAGCATCCTCAATTTGGTCAATCAACAGGTTTTGATTACACACGGACAAAAAATCCTACCCGCACTGTTCTTGAAGAAACGCTGGCTAAAATTGAAAAGGCTAAATACGCTTTAGTAACATCGTCGGGTATGGCGGCGCTTGTTTTGCTTTTTACTGGCTTTCCTATTGGGAGTAAGGTAGTTGCGGCGCGTGATTTATATGGTGGTTCTTTTCGTTGGTTTAACGAACAGGAAAAAGCAGGAAGATTTTCTTTTGTTTACACCAATACAGAAACTGATATGATTGCTGCCATTTCAGATGAGACCGATTATGTTTTTATCGAAACGCCAACCAATCCGCTCATGATTGAATTTGACATTAGTAAAGTTGCTCAAGCAGCTCATAAGCATGGTGCCAAGGTCATTGTTGATAACACTTTTTACAGCCCTATTTATCAAAATCCGCTCGTTTTAGGTGCTGATGTGGTTTTGCATTCAGCAACCAAGTATCTATCAGGTCATAATGATGTTCTTGCCGGTGTTTTAATGACCAGCGATCAAGAAATTTACGATAAGCTTTTTTATGACCAAAATACAACAGGTCCAACACTCTCGCCCTTAGATACTTATTTGCTGATGCGCGGTCTGAAAACACTTAAATTGCGTATGGAAAAAGCAACACAAAATGCTAAGACAGTTGTTGCTTATTTAGAAAAATCACCTGCTGTTAAAGAGGTACTTTATACAGGAAAAGGCGGAATGATTTCTTTTAAAGTTGTGGATGAAAAAAAAATTCCGCAAATTCTCAATCATTTACAGCTGTTCACCTTTGCAGAAAGTTTAGGTGGCGTTGAAAGTTTAATTACTTATCCAGCGACACAGACACACTTGGATATACCGGAGGAAGTGCGTCATTCCTATGGTTTGACAGATGACTTACTGCGTCTGTCCATTGGAATTGAAGATGCGGAAGACTTGATTGATGATTTAAAAGCTGCTTTAGAAGCTTAA","5.20","-10.57","40226","MTEDYKLDTILAHAGINTDKTTGALTAPIHLSTTYQHPQFGQSTGFDYTRTKNPTRTVLEETLAKIEKAKYALVTSSGMAALVLLFTGFPIGSKVVAARDLYGGSFRWFNEQEKAGRFSFVYTNTETDMIAAISDETDYVFIETPTNPLMIEFDISKVAQAAHKHGAKVIVDNTFYSPIYQNPLVLGADVVLHSATKYLSGHNDVLAGVLMTSDQEIYDKLFYDQNTTGPTLSPLDTYLLMRGLKTLKLRMEKATQNAKTVVAYLEKSPAVKEVLYTGKGGMISFKVVDEKKIPQILNHLQLFTFAESLGGVESLITYPATQTHLDIPEEVRHSYGLTDDLLRLSIGIEDAEDLIDDLKAALEA","1590494","For other 'met' genes see SMu0796 (metE),(metC); SMu1492 (metS); SMu1335 (metA) and SMu1430 (metK).","cystathionine gamma-synthase","Cytoplasm","Significant hits in gapped BLAST to Cystathionine gamma-synthase. Residues 1-363 are 70% similar to >gi|15903420 as seen in S. pneumoniae. Residues 4-363 are 69% similar to gi|15673899 of L.lactis.SMu1527 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000277
Family

Cys/Met metabolism pyridoxal-phosphate-dependent enzymes
PTHR11808	$\"[85-364]T$	Cys_Met_Meta_PP
PF01053	$\"[8-363]T$	Cys_Met_Meta_PP
PS00868	$\"[189-203]T$	CYS_MET_METAB_PP

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[3-247]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015422
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 2
G3DSA:3.90.1150.10	$\"[248-363]T$	PyrdxlP-dep_Trfase_major_sub2

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[3-363]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PIRSF001434	$\"[6-364]T$	CGS
PTHR11808:SF15	$\"[85-364]T$	PTHR11808:SF15

","BeTs to 7 clades of COG0626COG name: Cystathionine beta-lyases/cystathionine gamma-synthasesFunctional Class: EThe phylogenetic pattern of COG0626 is ---kY-VcEBRHuj-------Number of proteins in this genome belonging to this COG is 2","***** IPB000277 (Cys/Met metabolism pyridoxal-phosphate-dependent enzymes) with a combined E-value of 1.1e-94. IPB000277A 45-66 IPB000277B 135-168 IPB000277C 172-207 IPB000277D 229-269 IPB000277E 308-324 IPB000277F 341-358","Residues 8-363 are 69% similar to a (AMINOTRANSFERASE PHOSPHATE PYRIDOXAL COMPLETE PROTEOME) protein domain (PD000087) which is seen in Q9CEC6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 08:21:08 2002","Tue Feb 5 21:33:49 2002","Thu Oct 17 08:21:08 2002","Mon Apr 8 11:00:09 2002","Tue Feb 5 21:33:49 2002","Tue Feb 5 21:33:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1527 is paralogously related (blast p-value < 1e-3) to SMu1074, a predicted O-acetylhomoserine sulfhydrylase.","Thu Feb 7 13:56:49 2002","Tue Feb 5 21:33:49 2002","pdb|1CS1|A Chain A, Cystathionine Gamma-Synthase (Cgs) From Esc... 291 7e-080pdb|1QGN|A Chain A, Cystathionine Gamma-Synthase From Nicotiana... 191 1e-049pdb|1CL2|A Chain A, Cystathionine Beta-Lyase (Cbl) From Escheri... 108 9e-025","SMU.1675c","","Residues 8 to 363 (E-value = 9.3e-169) place SMu1527 in the Cys_Met_Meta_PP family which is described as Cys/Met metabolism PLP-dependent enzyme (PF01053)","Tue Feb 5 21:33:49 2002","","","","Auger S, Yuen WH, Danchin A, Martin-Verstraete I.The metIC operon involved in methionine biosynthesis in Bacillus subtilis is controlled by transcription antitermination.Microbiology. 2002 Feb;148(Pt 2):507-518.PMID: 11832514","","Tue Feb 26 13:53:13 2002","1","","","SMU.1675c","" "SMu1528","1593412","1591799","1614","ATGACACAGCAAGAGCAAATGGTTCGAGGAACTGCCTGGCTGACTGCTGGTAATTTCATTAGCCGCCTCCTCGGAGCTGTTTATATTATTCCTTGGTATGCATGGATGGGAAAATATGCAGCAGAAGCTAATGCTCTTTTTGGAATGGGTTATGAAATCTATGCCCTTTTTTTACTGATTTCAACTGTCGGTATTCCTGTTGCTGTTGCTAAACAGGTTTCAAAGTATAACACACTGGGAGACCCTAAAAAAAGTACCTATCTTGTGCGAAAGATTTTGCATTTTATGCTTGGTTTAGGTGCCATCTTTGCTGTTATTATGTATATGGGATCACCTGTTTTTGCCAGTATGAGCCGTGGCGGTCAAGACTTAGTACCTGTTCTTAGAAGTTTAACTTTGGCAGTTCTTGTTTTTCCGTCCATGAGCGTTTTAAGAGGCTTTTTTCAAGGGTTTAATAATCTTAAACCTTATGCCATAAGTCAAATAGCTGAACAAGTTGTTCGGGTTATTTGGATGCTTTTAACAGCTTTCTTTATCATGAAGATGAGCTCAGGAGACTATGTTGACGCAGTAACACAGTCTACTTTTGCTGCCTTTGTCGGAATGTTTGCAGGGATTGCAGTTCTTATTTATTTCCTATGGGAAAATGATTTGTTAGATGCCTTATTTGGCAAAAAGCCTGAAAAGGTTGATATTGATACCAAGGATCTCCTTATTGAAACAGTTAAGGAGGCTATTCCTTTTATCGTTACAGGTTCGGCTATTCAGGTTTTTAAACTGATTGATCAATTCACTTTTGGCAATAGTATGGCTCTTTTCACACATTATAGTGATAGAGAATTAAAAGTTATGTTTGCCTATTTTTCGACAAATCCAGGCAAGGTTACGATGATTTTGATTGCTGTTGCGACAGCGATTGCAGGTGTCGGTATTCCCTTGTTAACAGAGAATTTTGTCAAAAAAGATAAAAAAGCTGCGGCACGCTTAGTTGTTAATAATTTACAAATGCTGATGATTTTTATCATTCCTGCCATTATAGGAGCTGTTATTTTAGCTAAGCCGCTCTATACTATTTTTTACGGTCTGCCTCAGGGACAAGCGTTGGGGCTATTCATCGTTTCTTTACTGCAGACAATTATTTTAGCTATCTATACGGTTTTAGCTCCGATGCTGCAAGCTTTATTTGAAAATCGTAAGGCTATTCGTTACTTTATTTATGGTGTTATTGCTAAATTTGTTTTACAAGTTCCTCTCATTTATTTCTTGCAGGCCTATGGTCCAATATTAGCAACAACGTTTGCCCTATTCATTCCAATTATTCTGATGTACCTTCAAATACAAAAAATTACAGGCTTTAATCGTACTGCCATTAGAAGAACAAGCCTTTTAGTGTTGATTTTGACAGCAATCATGACTGTTGTTGTCGTTTTGGCAACTTGGCTGCTGGGGCTAATTCTATCAGATAATAGTCGAATCGCTAGTCTTATTTACATTACAGTGATTGGTTTTATTGGTATAGTTGTTTATGGTATCTTGGCTTTAGCTACTCATCTTCTTGATAAAATGTTGGGTACTAAGGCGGTCAGCCTTCGTCGGAAGCTGCATATGAATTAA","10.60","19.96","59489","MTQQEQMVRGTAWLTAGNFISRLLGAVYIIPWYAWMGKYAAEANALFGMGYEIYALFLLISTVGIPVAVAKQVSKYNTLGDPKKSTYLVRKILHFMLGLGAIFAVIMYMGSPVFASMSRGGQDLVPVLRSLTLAVLVFPSMSVLRGFFQGFNNLKPYAISQIAEQVVRVIWMLLTAFFIMKMSSGDYVDAVTQSTFAAFVGMFAGIAVLIYFLWENDLLDALFGKKPEKVDIDTKDLLIETVKEAIPFIVTGSAIQVFKLIDQFTFGNSMALFTHYSDRELKVMFAYFSTNPGKVTMILIAVATAIAGVGIPLLTENFVKKDKKAAARLVVNNLQMLMIFIIPAIIGAVILAKPLYTIFYGLPQGQALGLFIVSLLQTIILAIYTVLAPMLQALFENRKAIRYFIYGVIAKFVLQVPLIYFLQAYGPILATTFALFIPIILMYLQIQKITGFNRTAIRRTSLLVLILTAIMTVVVVLATWLLGLILSDNSRIASLIYITVIGFIGIVVYGILALATHLLDKMLGTKAVSLRRKLHMN","1591815","","polysaccharide transporter","Membrane, Cytoplasm, Extracellular","Significant hits in gapped BLAST to hypothetical proteins and polysaccharide transporters. Residues 3-537 are 54% similar to >gi15903426 as seen in S. pneumoniae. Residues 7-537 are 54% similar to >gi15901374 as seen in S. pneumoniae. Residues 4-536 are 42% similar to >gi15673787 as seen in L. lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1390 (0.0).","

InterPro
IPR002797
Family

Polysaccharide biosynthesis protein
PF01943	$\"[7-318]T$	Polysacc_synt

","BeTs to 7 clades of COG2244COG name: Membrane protein involved in the export of O-antigen and teichoic acid, RfbX familyFunctional Class: RThe phylogenetic pattern of COG2244 is aMTK-Qv-EB-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 378-533 are 23% similar to a (PROTEOME COMPLETE CORTEX SPORE) protein domain (PD100139) which is seen in Q9K7T2_BACHD.Residues 124-264 are 31% similar to a (B REQUIREMENT TEMPERATURE MFD-DIVIC) protein domain (PD017270) which is seen in Q9ZIM2_LISMO.Residues 161-360 are 24% similar to a (PROTEOME COMPLETE BIOSYNTHESIS) protein domain (PD040867) which is seen in Q9K7T2_BACHD.Residues 123-160 are 68% similar to a (PROTEOME COMPLETE YSGC) protein domain (PD377147) which is seen in Q9CEN2_LACLA.Residues 362-536 are 32% similar to a (PROTEOME COMPLETE YSGC) protein domain (PD399507) which is seen in Q9CEN2_LACLA.Residues 161-360 are 43% similar to a (PROTEOME COMPLETE YSGC YTGP) protein domain (PD415879) which is seen in Q9CEN2_LACLA.Residues 4-108 are 56% similar to a (COMPLETE PROTEOME TRANSMEMBRANE VIRULENCE) protein domain (PD005504) which is seen in Q9CEN2_LACLA.Residues 132-330 are 25% similar to a (COMPLETE PROTEOME SPORULATION B) protein domain (PD338062) which is seen in Q9L472_BACAN.Residues 379-453 are 33% similar to a (PROTEOME COMPLETE TRANSMEMBRANE VIRULENCE) protein domain (PD001019) which is seen in O34674_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 26 13:56:36 2002","Thu Aug 10 10:24:54 2006","Thu Aug 10 10:24:54 2006","Thu Oct 17 08:19:59 2002","","Tue Feb 5 21:41:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1528 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Feb 26 13:56:36 2002","","No significant hits to the NCBI PDB database.","SMU.1676c","","Residues 7 to 318 (E-value = 2.7e-15) place SMu1528 in the Polysacc_synt family which is described as Polysaccharide biosynthesis protein (PF01943)Residues 36 to 497 (E-value = 4.7e-05) place SMu1528 in the MVIN family which is described as MviN-like protein (PF03023)","Thu Aug 10 10:24:54 2006","24380054","","","","","","1","","","SMU.1676c","147" "SMu1529","1593522","1594973","1452","ATGATTACAATTGAAACAGTATTAACGATTCTTAAAAATAATGCTAATTTTCGCGAAATAATTGATGGTAAGCATTATCAATACAAATACTCAAATCCAGAAGTGGCTTTTCATCACATTTCTTATGATAGTCGTGACATTAAAGCCTCAACCCTCTTTTTTGTTAAGGGAGCAACTTTCAAAAAAGAATTTCTAGAAAAAGCTATCGAAAGCGGATTAACCTTTTATGTAGCAGAAAAAGATTATCAAGTGGGTATTCCGCTTATTCTTGTTAATAATATCAAAAATGCCATGTGTCTGATTGCTAAGGAATTTTATGACAACCCTCAAGATAAGTTGAAAACTTTGGCTTTTACAGGAACTAAAGGCAAAACAACAGCTGCTTATTTTGCTTATCATATCTTAAAGCAAGGCTACCGTCCGGCCATGATTTCTACCATGAACACAACCCTAGATGGAAAAACTTTCTTCAAATCAAAACTAACAACCCCCGAGAGCTTAGATCTTTTTAAAATGATGGCACAGGCAGTTGCTAATGGCATGACTCATCTCATTATGGAAGTCTCAAGTCAAGCTTACCTAGTTGGCCGTGTTTACGGACTGACTTTTGATGTTGGTGTTTTTCTCAATATTAGTCCTGATCATATTGGACCGATTGAACATCCTACTTTTGAAGATTATTTTTACCATAAGCGTCTTTTACTGAAACATAGTCGTTATGTTATCGTCAATAGTCAGATGAATCATTTTGCACTCATCAAAGAACAGGTTGCCGACCAGCCACATGATTTCTATGGGAAATATTCTGACAATCAAATTATAAACAGCAAGGCTTTTTCATTTGATCTGACGGGCAAATTAGCAGGCCATTATGACATTCAGCTGACAGGCTCGTTCAATCAAGAAAATGCAGTTGCTGCTGCCTTGGCCTGCTTACAGCTAGGAGCTAGCCAGACTGATATTCAAAAAGGCATCGTTCAAACAACGGTGCCGGGGCGCATGGAAGTTCTCATTCAAAAGAATGGTGCTAAGGTCTTTGTTGATTATGCTCACAACGGAGATAGTTTAGAAAAACTATTGTCAGTTGTTGAAGAACATCAAAAAGGAACTTTAATTCTTATTCTTGGCGCTCCTGGAAATAAAGGAGAAAGCCGCCGAGCTGATTTTGGTTATGTTATCAATGCTCATCCAGAGTTGCAAGTTATTTTAACTGCAGATGATCCTAACAATGAAGACCCACAGCTCATCTCTCAAGAGATTGCTCATCATATCAAACGTCCAGTAAACATTATTGTTGATCGTAAGCAAGCTATTCAAAAAGCTATGTCATTGACGCAGTCTGAAAACGATGCTGTCATTATAGCTGGTAAAGGAGCTGATGCTTTTCAAATTATTAAGGGAAAGCGCACAGCATATGCTGGTGATATTGAAGTGGCTAGAAAATACCTTTAG","8.20","5.02","54006","MITIETVLTILKNNANFREIIDGKHYQYKYSNPEVAFHHISYDSRDIKASTLFFVKGATFKKEFLEKAIESGLTFYVAEKDYQVGIPLILVNNIKNAMCLIAKEFYDNPQDKLKTLAFTGTKGKTTAAYFAYHILKQGYRPAMISTMNTTLDGKTFFKSKLTTPESLDLFKMMAQAVANGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLLKHSRYVIVNSQMNHFALIKEQVADQPHDFYGKYSDNQIINSKAFSFDLTGKLAGHYDIQLTGSFNQENAVAAALACLQLGASQTDIQKGIVQTTVPGRMEVLIQKNGAKVFVDYAHNGDSLEKLLSVVEEHQKGTLILILGAPGNKGESRRADFGYVINAHPELQVILTADDPNNEDPQLISQEIAHHIKRPVNIIVDRKQAIQKAMSLTQSENDAVIIAGKGADAFQIIKGKRTAYAGDIEVARKYL","1594983","For other 'mur' genes see SMu0549 (murF); SMu0653 (murN); SMu0654 (murM); SMu0883 (murB); SMu1566 (murI); SMu0498 (murD);SMu0499 (murG); SMu1577 (murC); SMu1304 (murC);SMu1386 (murA) and SMu1429 (murZ). ","UDP-N-acetylmuramoylananine-D-glutamate-2,6-diaminopimelate ligase; UDP-MurNac-tripeptide synthetase","Cytoplasm","Significant hits in gapped BLAST to UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase. Residues 1-483 are 68% similar to >gi15674533 as seen in S. pyogenes. Residues 1-483 are 67% similar to >gi15901375 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1391 (0.0).","

InterPro
IPR004101
Domain

Cytoplasmic peptidoglycan synthetases, C-terminal
PF02875	$\"[330-417]T$	Mur_ligase_C

InterPro
IPR005761
Family

UDP-N-acetylmuramyl-tripeptide synthetase
TIGR01085	$\"[32-483]T$	murE

InterPro
IPR012237
Family

UDP-N-acetylmuramate-alanine ligase
PIRSF001562	$\"[17-476]T$	UDP-NAcM_Alig

InterPro
IPR013221
Domain

Mur ligase, middle region
PF08245	$\"[116-311]T$	Mur_ligase_M

noIPR
unintegrated

unintegrated
G3DSA:3.40.1190.10	$\"[109-333]T$	G3DSA:3.40.1190.10
G3DSA:3.40.1390.10	$\"[17-108]T$	G3DSA:3.40.1390.10
G3DSA:3.90.190.20	$\"[335-482]T$	G3DSA:3.90.190.20
PTHR23135	$\"[119-136]T$ $\"[157-483]T$	PTHR23135
PTHR23135:SF4	$\"[119-136]T$ $\"[157-483]T$	PTHR23135:SF4
SSF53244	$\"[330-482]T$	SSF53244
SSF53623	$\"[109-329]T$	SSF53623
SSF63418	$\"[15-108]T$	SSF63418

","BeTs to 12 clades of COG0769COG name: UDP-N-acetylmuramyl tripeptide synthaseFunctional Class: MThe phylogenetic pattern of COG0769 is --T--qvCebRhuj--olinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 245-325 are 51% similar to a (SYNTHETASE MESO-) protein domain (PD392133) which is seen in MURE_LACLA.Residues 298-466 are 29% similar to a (SYNTHETASE CYANOPHYCIN ATP-BINDING LIGASE) protein domain (PD122298) which is seen in Q9F2I7_SYNEL.Residues 1-173 are 45% similar to a (SYNTHETASE MESO-) protein domain (PD399268) which is seen in MURE_LACLA.Residues 174-244 are 78% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS ENZYME) protein domain (PD212530) which is seen in MURE_LACLA.Residues 406-483 are 32% similar to a (SYNTHETASE MESO-) protein domain (PD392605) which is seen in MURE_THEMA.Residues 330-458 are 62% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS) protein domain (PD001216) which is seen in MURE_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 10 10:28:47 2006","Tue Feb 5 21:50:35 2002","Thu Aug 10 10:28:47 2006","Thu Apr 4 08:57:48 2002","","Tue Feb 5 21:50:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1529 is paralogously related (blast p-value < 1e-3) to SMu0549, a predicted D-Ala-D-Ala adding enzyme, and SMu0763, a predicted folyl-polyglutamate synthetase.","Thu Feb 7 13:59:05 2002","","No significant hits to the NCBI PDB database.","SMU.1677","","Residues 48 to 322 (E-value = 9.6e-34) place SMu1529 in the Mur_ligase family which is described as Mur ligase family, catalytic domain (PF01225)Residues 330 to 419 (E-value = 4e-20) place SMu1529 in the Mur_ligase_C family which is described as Mur ligase family, glutamate ligase domain (PF02875)","Thu Aug 10 10:28:47 2006","24380055","","","Ludovice AM, Wu SW, de Lencastre H.Molecular cloning and DNA sequencing of the Staphylococcus aureus UDP-N-acetylmuramyl tripeptide synthetase (murE) gene,essential for the optimal expression of methicillin resistance.Microb Drug Resist. 1998 Summer;4(2):85-90.PMID: 9650993","","Tue Feb 26 14:26:27 2002","1","","","SMU.1677","148" "SMu1530","1595207","1596226","1020","ATGATCATAGCAGTCTGTTTAGGAATTCTTTTTGTTATCATTTTAGGGGTTCTTTTCATTTTTACCATGAGATCTTTTCACAATTTTAAGTACAGTTCACAAGGAATCCCTAACACTCCTGACTATTATACCAATCCTAGTAAACTTTCTCTTTATAAAACTGATATTGCTGGTCTTACTATTGAACACGTAACAGGAGATTATCTCAATGGATTCAGGATAATTCCAGATAACATTAAGTATAAAGGTGTTATTGTAACTTTTGGGGGCTCCGATGGCACGCCTGCTTATGAACAAGCTGTTCAATTAGCTCAAGAAGGTTATCAGGTTTTAGCCCTATTCTTCTTTGGTATGCCCAATCAACATCCAACACTTGCTGAAGTGCCAGTAGAATATTATCAAGAAATTGAAAGCTATATTTCACAACACTTTAGTCAACCTGATAAGATTACTGTAATTGGAACATCTAAAGGTGCAGAATATGCCCTACTGCTTGCCAGTCTCTATGATTCTATTGATAATGTTGTTCTATATGCTCCTTCTAGCCACATTTATGCTGGCTTGGATTTTAGAAACTACTCCTCTTCTTGGTCACAAAATGGTAAAGCACTGCCTTACTTGGATGTCCGTTCAGAAAATTCTCTAAAACTCTTCTATAATTTTTTGATAAAAACACCTATTTCTTATTATCATACCTACAAACAGGCTTTAGATAAGGATAAAAACAGTGAAGACAAACGTATTAAAGTTGAAAAGACAAAAGCAAATATTCTCATTTTTGCCGGAGAAAATGATAGGATGTGGCCAAGCGCTGAATCTGCAAGACTGATCGAAAAGTATCAGCCAAATCATACGCAAGTGACTATCTACAAAGAAGCTGGTCATCTTTTTGCCGGAGACGGAATTGTTGACAGCCGCGGCATATACCTGTCGGTTGGTGGAAATAAAGCAGCTAATGAGACTGCTAAAAAGGACAGTGACCAAAGACTCAAAAAACAGTTAAGCATTTGGCATAGCTAA","7.30","1.12","38189","MIIAVCLGILFVIILGVLFIFTMRSFHNFKYSSQGIPNTPDYYTNPSKLSLYKTDIAGLTIEHVTGDYLNGFRIIPDNIKYKGVIVTFGGSDGTPAYEQAVQLAQEGYQVLALFFFGMPNQHPTLAEVPVEYYQEIESYISQHFSQPDKITVIGTSKGAEYALLLASLYDSIDNVVLYAPSSHIYAGLDFRNYSSSWSQNGKALPYLDVRSENSLKLFYNFLIKTPISYYHTYKQALDKDKNSEDKRIKVEKTKANILIFAGENDRMWPSAESARLIEKYQPNHTQVTIYKEAGHLFAGDGIVDSRGIYLSVGGNKAANETAKKDSDQRLKKQLSIWHS","1596236","","conserved hypothetical protein","Membrane, Cytoplasm, Extracellular","Significant hits in gapped BLAST to Acyl-CoA thioesterases. Residues 62-297 are 31% similar to >gi|15896648 as seen in Clostridium acetobutylicum. Residues 85-334 are 29% similar to >gi|15891290 as seen in Agrobacterium tumefaciens.SMu1530 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR014940
Domain

BAAT/Acyl-CoA thioester hydrolase C-terminal
PF08840	$\"[128-336]T$	BAAT_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1820	$\"[82-300]T$	G3DSA:3.40.50.1820
SSF53474	$\"[54-334]T$	SSF53474

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 76-331 are 22% similar to a (HYDROLASE ACYL-COA THIOESTER PEROXISOMAL ESTERASE SERINE) protein domain (PD006914) which is seen in MTE1_MOUSE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 13:59:55 2002","Tue Feb 26 14:27:13 2002","Thu Feb 7 13:59:55 2002","Tue Feb 5 21:57:04 2002","","Tue Feb 5 21:57:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1530 is paralogously related (blast p-value < 1e-3) to SMu0575, a predicted thioesterase.","Thu Feb 7 13:59:55 2002","","No significant hits to the NCBI PDB database.","SMU.1678","","No significant hits to the Pfam 11.0 database","Tue Feb 5 21:57:04 2002","24380056","","","","","","1","","","SMU.1678","" "SMu1531","1596913","1596404","510","ATGATAGAAAGATTAGACTTTGTTTGCCCAACAATTCCTGAAGGCGGTGAATTTCCACTTGAACATACGGGCAAGGGAGAAGACAGATCACCTGAATTTTTTATCAAAAATCTTTCTCCTCATGCAAGAACACTTGCTATTACTTTAGAAGATTTGACACACCCTCTCAAAAAGGAATTCACGCATTGGTTGATTTGGAATCTTCCTGCTTCTAGTTATATCAAGGCTAATATTTCTTACGGATTTGAAGTAGCAGATCCTCAAGAAGCTAGACAGGGAATAGCTTATGGTTGGCATCGTTATGCTGGTCCAAAACCACCGCTGGGTCAAAATCATAAGTATCGCTTTACCATTTACAGTCTGGATTGTTCCTTGAATTTAAATCGCTGGACAAGAAAAAGCAAACTTTTAAAAGCAGTGGAAGGTCATGTCCTGCAAAAGGGACAACTAACGGCTTCTTTTGGCAATAAAAAGATCTGGAATCAAAATTCCAGACCAATGATGGTATGA","10.10","7.58","19406","MIERLDFVCPTIPEGGEFPLEHTGKGEDRSPEFFIKNLSPHARTLAITLEDLTHPLKKEFTHWLIWNLPASSYIKANISYGFEVADPQEARQGIAYGWHRYAGPKPPLGQNHKYRFTIYSLDCSLNLNRWTRKSKLLKAVEGHVLQKGQLTASFGNKKIWNQNSRPMMV","1596420","","conserved hypothetical protein","Cytoplasm","Significant hits in gapped BLAST to hypothetical proteins. Residues 3-157 are 35% similar to >gi|14591085 as seen in Pyrococcus horikoshii. Residues 19-157 are 37% similar to >gi|14521358 as seen in Pyrococcus abyssi.SMu1531 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005247
Family

YbhB and YbcL
TIGR00481	$\"[11-154]T$	YbhB_YbcL

InterPro
IPR008914
Family

PEBP
PF01161	$\"[10-157]T$	PBP

noIPR
unintegrated

unintegrated
G3DSA:3.90.280.10	$\"[5-154]T$	G3DSA:3.90.280.10
SSF49777	$\"[4-155]T$	SSF49777

","BeTs to 9 clades of COG1881COG name: Uncharacterized ACR, YbhB familyFunctional Class: SThe phylogenetic pattern of COG1881 is a-tkYq--EbR-uj----in-Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 35-145 are 38% similar to a (COMPLETE PROTEOME YBHB PH1269) protein domain (PD006154) which is seen in YC69_PYRHO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 14:01:06 2002","Tue Feb 5 22:02:14 2002","Thu Feb 7 14:01:06 2002","Tue Oct 8 18:55:13 2002","","Tue Feb 5 22:02:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1531 is paralogously related (blast p-value < 1e-3) to SMu1115, a conserved hypothetical protein.","Thu Feb 7 14:03:33 2002","","No significant hits to the NCBI PDB database.","SMU.1679c","","Residues 10 to 157 (E-value = 3.3e-06) place SMu1531 in the PBP family which is described as Phosphatidylethanolamine-binding protein (PF01161)","Tue Feb 5 22:02:14 2002","24380057","","","","","","1","","","SMU.1679c","" "SMu1532","1597559","1596939","621","ATGATGGTAAAGCGTCCTGATTTTTTCCAGATTAAAACCTATGAAGAGTTTTGCAAGTATTATTGGTATCAGAAAGAATTGTTGCATATTTGTCAGCAACTGGACTGTGCACATTGGGGAACAAAGCAGGAATTAAACGATAGGATAAAGGCTTATTTTGCAGGAGAACCAATGAAAGCAGTTGAAAGGAAGACTAAGCCTTTTAAACCAAAAGCGACACAAGAGCTTAGCTTATCCAGTTCTTTGCTATTGTGTGGTTTTGCCTTTAATCAAACGTTTAGGACTTATTTTGCCCAACAGACTGGCGTTGAACCCTTTAAATTCACTGCGGATATGGCAACAGCATGGCGGAAAGTCAAGGCAGAAAATGATCTTAGCTTTACTATCCAAGATCTTTTAGATGTTTATGCTGGAAAATCTGATTACGCAAGATATGATAATCGTTCCTGCCAATGGAATCAATTTTACAAGGATTTTTGTGCAGATAAAAAGACTAAAGGGATTAAAAATAAAATGAAAGTCGCTTCCATTCTTTGGCAAGCTGTCAAAAAATCTGATCAGGCCAAGGTTTACTCATCACAATTATGGGATAAATATTCAAATTTGTTAGATAATGAATAA","9.60","9.19","24327","MMVKRPDFFQIKTYEEFCKYYWYQKELLHICQQLDCAHWGTKQELNDRIKAYFAGEPMKAVERKTKPFKPKATQELSLSSSLLLCGFAFNQTFRTYFAQQTGVEPFKFTADMATAWRKVKAENDLSFTIQDLLDVYAGKSDYARYDNRSCQWNQFYKDFCADKKTKGIKNKMKVASILWQAVKKSDQAKVYSSQLWDKYSNLLDNE","1596955","","hypothetical protein","Periplasm, Cytoplasm","No significant hits in gapped BLAST.SMu1532 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000005
Domain

Helix-turn-helix, AraC type
PR00032	$\"[78-93]T$ $\"[93-109]T$	HTHARAC

InterPro
IPR004360
Domain

Glyoxalase/bleomycin resistance protein/dioxygenase
PF00903	$\"[1-118]T$	Glyoxalase

InterPro
IPR011588
Domain

Glyoxalase/extradiol ring-cleavage dioxygenase
PD002334	$\"[2-117]T$	Gly_diox

noIPR
unintegrated

unintegrated
G3DSA:3.10.180.10	$\"[2-118]T$	G3DSA:3.10.180.10
SSF54593	$\"[1-121]T$	SSF54593

","No hits to the COGs database.","***** IPB000325 (Glyoxalase I) with a combined E-value of 7.7e-07. IPB000325A 4-42 IPB000325D 105-117","Residues 2-119 are 50% similar to a (PROTEOME COMPLETE VCA0432 PA3956) protein domain (PD084684) which is seen in O68053_RHOCA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 18:53:17 2002","Tue Feb 5 22:11:01 2002","Tue Oct 8 18:53:17 2002","Tue Feb 5 22:11:01 2002","Tue Feb 5 22:11:01 2002","Tue Feb 5 22:11:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1533 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 18:53:17 2002","","No significant hits to the NCBI PDB database.","SMU.1681c","","Residues 1 to 118 (E-value = 4e-08) place SMu1533 in the Glyoxalase family which is described as Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily (PF00903)","Tue Feb 5 22:11:01 2002","24380059","","","","","","1","","","SMU.1681c","" "SMu1534","1598570","1597995","576","ATGAAAAATGACGTTCTTGTTTATGTATTTGATGGTTATGCAGACTGGGAGCCATCTTATGTCTGCTCGGAATTAAATAGGCAGGACAGTCCCTTTCAGATTAAAACTATTAGTTTAGACAAGCAGCCTAAAACATCCATGGGCGGATTTCGCGTGATGCCTGACTATGATATTTCCAACTATCCTAAGAAATTTAAACTGCTAATTATTCCTGGCGGAGATAGTTGGCTGGCAGGGGAAAATACTGACATTCTGCCTGTAGTAGACTATGCTGCTCGCCAGCAAATACCGATTGCTGCCATTTGTGCTGCAACCAGTTTTTTAGCTGAAAATGCTTATTTAGATCATGTCAAGCACACTGGCAATAGCCTTGAATTTATGAAAAAAGGAGCTCCTAGCTATCGAGGAGAAGACTTTTATGTGGAAAGACAGGCAGTCAGTGATGGTGGTATTGTGACAGCAAATGGGACAGCAGCCTTAGAATTTGCTAGAGAAATTTTCTTTTTACTACATGTTAAAAATCCCCAAGAAATAGAGGATTGGTACCATTTTAACAAAGTGGGCTTTTATCATTAA","5.10","-5.89","21603","MKNDVLVYVFDGYADWEPSYVCSELNRQDSPFQIKTISLDKQPKTSMGGFRVMPDYDISNYPKKFKLLIIPGGDSWLAGENTDILPVVDYAARQQIPIAAICAATSFLAENAYLDHVKHTGNSLEFMKKGAPSYRGEDFYVERQAVSDGGIVTANGTAALEFAREIFFLLHVKNPQEIEDWYHFNKVGFYH","1598011","","conserved hypothetical protein (possible intracellular protease)","Cytoplasm","Significant hits in gapped BLAST. Residues 6-191 are 41% similar to >gi|16077578 as seen in B. subtilis. Residues 5-186 are 39% similar to >gi|16078939 as seen in B. subtilis.SMu1534 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002818
Domain

ThiJ/PfpI
PF01965	$\"[17-171]T$	DJ-1_PfpI

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.880	$\"[3-170]T$	G3DSA:3.40.50.880
PTHR11019	$\"[37-166]T$	PTHR11019
SSF52317	$\"[1-170]T$	SSF52317

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-186 are 40% similar to a (PROTEOME COMPLETE YOAZ YDEA) protein domain (PD036566) which is seen in P96658_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 18:52:19 2002","Fri Jan 3 15:49:30 2003","Fri Jan 3 15:49:30 2003","Tue Feb 5 22:17:37 2002","","Tue Feb 5 22:17:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1534 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 18:52:19 2002","","No significant hits to the NCBI PDB database.","SMU.1682c","","Residues 17 to 171 (E-value = 2.1e-09) place SMu1534 in the DJ-1_PfpI family which is described as DJ-1/PfpI family (PF01965)","Tue Feb 5 22:17:37 2002","24380060","","","","","","1","","","SMU.1682c","" "SMu1535","1599557","1598634","924","ATGAAATTAGAAAGATTACTGGCTATTTTATCCCTACTTTCAGATAGAAATAGGATAACAGCTAAAGAACTAGCAGAAAAATTTGAGGTGTCCAAACGGACTATTTATCGAGATTTAGAAAGCCTTAATCAAGCAGGAATTCCCATTGTTTCCTATGCTGGTCGCGACGGTGGACTTTCGCTGATGAAAAACTATCAGATAGACAAACGCATCCTATCAAAAGCAGATACCAAAAATCTTTACTCTGCTTTAAAGGGCTTACAAAGCATTAAGCAGCAGCCAGAATTGATTGCCTTGATAGCGAAACTTCTGCCTGAGGAAAAGAGTAATCCTTTAGCAGATTATGATATTAATTTTTCTTCTTGGTATGCTGACAGCCTTATTCAAAAGAAAATTGAAATACTGCAAAAGGCTATTGAAGAAAGAATTTGTGTTTTATTGGATTATATTTCAAGTTCTGGCAGAAGGAAGCGCAAAATTGAGCCCTATCAATTAGTTTTTAAAGATTCAGCCTGGTATCTGCATGCCTTTTGTCATAAACGACAGGCTTTTCGTCTTTTTAAACTGCGGCGTATGGTATCTTTAACCTTGCTAGAAGAAAAATTTCCAGGACGTCCTTATCCAGCTTTAACATTAAAAAGCATTGCTTATTCTGATTTTTCTTTGGAACCTGTTGAAGGTTATGACAAGGTTGTTTTGACTTATCATCCTGAGGATGCCTTTGCTATAACCAAAGTGATGGATGCTTCTATACTAGCTGCTTCTGAAAAAGAAGGCATGGTTACTTTTTATACGTCAAATTTAGCTATGGCTTGTGATTTGGTTTTTCAATTACTAACAAAGATCAGTGTTCTTGCACCAATTGAATTGCAGCAACTAGTTGAGAAAAAATTGGACAAAATTAAATCATTCTATAAAAGGTGA","10.10","11.59","35234","MKLERLLAILSLLSDRNRITAKELAEKFEVSKRTIYRDLESLNQAGIPIVSYAGRDGGLSLMKNYQIDKRILSKADTKNLYSALKGLQSIKQQPELIALIAKLLPEEKSNPLADYDINFSSWYADSLIQKKIEILQKAIEERICVLLDYISSSGRRKRKIEPYQLVFKDSAWYLHAFCHKRQAFRLFKLRRMVSLTLLEEKFPGRPYPALTLKSIAYSDFSLEPVEGYDKVVLTYHPEDAFAITKVMDASILAASEKEGMVTFYTSNLAMACDLVFQLLTKISVLAPIELQQLVEKKLDKIKSFYKR","1598650","","conserved hypothetical protein","Cytoplasm","Significant hits in gapped BLAST to transcription regulators. Residues 15-306 are 32% similar to >gi|5759267 as seen in Enterococcus faecium. Residues 15-306 are 30% similar to >gi|16799540 as seen in L. innocua.SMu1535 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001034
Domain

Bacterial regulatory protein, DeoR N-terminal
SM00420	$\"[5-51]T$	HTH_DEOR
PS51000	$\"[2-57]T$	HTH_DEOR_2

InterPro
IPR013196
Domain

Helix-turn-helix, type 11
PF08279	$\"[5-60]T$	HTH_11

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-64]T$	SSF46785

","No hits to the COGs database.","***** IPB001034 (Bacterial regulatory protein, DeoR family) with a combined E-value of 6.1e-07. IPB001034A 19-54","Residues 135-202 are 47% similar to a (REGULATOR PROTEOME TRANSCRIPTIONAL) protein domain (PD021258) which is seen in Q9S3S5_ENTFC.Residues 15-130 are 40% similar to a (PROTEOME TRANSCRIPTION COMPLETE) protein domain (PD267538) which is seen in Q9S3S5_ENTFC.Residues 16-81 are 37% similar to a (REGULATOR TRANSCRIPTIONAL DNA-BINDING) protein domain (PD014122) which is seen in Q9S2Q2_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 14:03:09 2002","Tue Feb 5 22:21:37 2002","Thu Feb 7 14:03:09 2002","Tue Feb 5 22:21:37 2002","Tue Feb 5 22:21:37 2002","Tue Feb 5 22:21:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1535 is paralogously related (blast p-value < 1e-3) to SMu1338, a conserved hypothetical protein, and SMu0445, a predicted DeoR-type transcriptional regulator.","Thu Feb 7 14:03:09 2002","","No significant hits to the NCBI PDB database.","SMU.1683c","","No significant hits to the Pfam 11.0 database","Tue Feb 5 22:21:37 2002","24380061","","","","","","1","","","SMU.1683c","" "SMu1536","1600265","1599615","651","ATGATTAAAATTTATAATGGCGATAAATTAACGCGTCAGCCATTTTTCATAAAACTTATCAACTATTTGCAAATACATGATGATGTCACTTTGCGGCAGATTAAGAGGAATTTTGCTGATACTGAGCATCTAGAACGATCTATTGAGGACTATGTGCAGGCGGGTTATGTTTTACGTGAAAATAAACATTATTACAATGCTTTTGAGCTGTTAGAGAACCTTGATGGTTTGACACTGGATAGTCAGATTTTTGTCGATGACCAGTCATCTATTTATCAAGATCTGTTAGCCTTAACTTTTGAGACCTATTTGTCTAACCAGACAAATGCAGCTCTTATCATTGAAAAGACGGATATTAGCAGAGATGCCTTAACCTTATCTAACTACTTTTTTAAACTTAATGAAAATTTTCCTCTATCAAGAAAACAAAAGCCCTTGTATCATTTATTGGGTGATGTCAATCCGAATTATGCTCTCAAATACATGACTACCTTTCTTTTGAAATTTTGGGGTAAGGATGTGGTCAAGCAGAAACGTCCTGATATTTTTGTCCAAGCCTTAGTGCTCTTAGGTTATTTGGAGCAAGTAGGTAAACAGAGTTATTGTTTGAAAATGACTTTTGATAAGGAAAAATTGATTTTCGCATCATAA","7.00","0.00","25423","MIKIYNGDKLTRQPFFIKLINYLQIHDDVTLRQIKRNFADTEHLERSIEDYVQAGYVLRENKHYYNAFELLENLDGLTLDSQIFVDDQSSIYQDLLALTFETYLSNQTNAALIIEKTDISRDALTLSNYFFKLNENFPLSRKQKPLYHLLGDVNPNYALKYMTTFLLKFWGKDVVKQKRPDIFVQALVLLGYLEQVGKQSYCLKMTFDKEKLIFAS","1599631","This sequence corresponds to the previously published gi|2959534 of unknown definition in GenBank. ","conserved hypothetical protein","Cytoplasm","Significant hits in gapped BLAST to streptococcal hypothetical protein. Residues 1-214 are 57% similar to >gi|15674528 as seen in S. pyogenes. Residues 1-95 are 100% similar to >gi|2952534 as seen in S. mutans.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1396 (3e-59).","

InterPro
IPR014924
Family

Domain of unknown function DUF1803
PF08820	$\"[2-94]T$ $\"[126-216]T$	DUF1803

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-210 are 38% similar to a (PROTEOME COMPLETE) protein domain (PD401141) which is seen in Q9CEM6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:57:57 2002","Tue Feb 5 22:29:09 2002","Tue Oct 8 17:57:57 2002","Tue Feb 5 22:29:09 2002","","Tue Feb 5 22:29:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1536 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 09:53:25 2002","","No significant hits to the NCBI PDB database.","SMU.1685c","","No significant hits to the Pfam 11.0 database","Tue Feb 5 22:29:09 2002","24380062","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)11029425","","Wed Feb 27 09:53:25 2002","","1","","","SMU.1685c","829" "SMu1537","1601404","1600472","933","ATGTCTAAAATTTTAGTTTTTGGTCATCAAAATCCCGATTCAGATGCAATCGGTTCATCAATGGCTTATGCATATTTAAAACGTCAACTCGGCGTAGATGCTCAAGCAGTAGCTTTAGGAAATCCAAATGAGGAGACAGCTTTTGTACTTGACTATTTTGGTATTCAAGCACCGCCTGTTGTTAAGTCAGCTCAAGCAGAAGGTGCCAAACAAGTCATCTTAACAGACCATAATGAATTTCAGCAATCTATCGCAGATATCCGCGAAGTTGAAGTCGTTGAAGTTGTAGATCATCATCGTGTCGCTAATTTTGAAACAGCAAATCCTCTTTATATGCGTTTAGAACCAGTTGGATCTGCTTCATCAATCGTTTATCGGCTTTACAAGGAAAATGGTGTTGCTATTCCTAAGGAAATTGCAGGAGTGATGCTGTCAGGTTTGATTTCAGATACACTTCTTTTGAAATCACCAACGACTCATGCCTCTGATCCAGCTGTTGCAGAAGATTTAGCCAAAATTGCAGGTGTTGACTTGCAGGAATATGGTTTGGCTATGCTTAAGGCTGGTACCAATTTAGCAAGTAAAACGGCTGCACAACTTGTTGATATTGATGCTAAAACATTTGAACTTAATGGTAGTCAAGTACGTGTAGCTCAAGTCAATACGGTTGATATCAATGAAGTTTTGGAACGTCAAAATGAAATTGAAGAAGCCATTAAAGCATCACAAGCAGCTAATGGATACTCTGATTTTGTCTTGATGATTACTGATATTTTAAATTCAAATTCGGAAATCTTAGCATTGGGCAACAATACTGATAAAGTAGAAGCAGCCTTTAATTTCACACTTAAAAATAACCATGCCTTCTTAGCAGGTGCTGTATCACGTAAGAAACAAGTTGTACCTCAATTAACGGAAAGTTTTAATGGGTAA","4.60","-13.54","33389","MSKILVFGHQNPDSDAIGSSMAYAYLKRQLGVDAQAVALGNPNEETAFVLDYFGIQAPPVVKSAQAEGAKQVILTDHNEFQQSIADIREVEVVEVVDHHRVANFETANPLYMRLEPVGSASSIVYRLYKENGVAIPKEIAGVMLSGLISDTLLLKSPTTHASDPAVAEDLAKIAGVDLQEYGLAMLKAGTNLASKTAAQLVDIDAKTFELNGSQVRVAQVNTVDINEVLERQNEIEEAIKASQAANGYSDFVLMITDILNSNSEILALGNNTDKVEAAFNFTLKNNHAFLAGAVSRKKQVVPQLTESFNG","1600488","For other 'dlt' genes see SMu1538 (dltD),(dlt4); SMu1539 (dltC) , (dlt3); SMu1540 (dltB),(dlt2) and SMu1541 (dltA),(dlt1).","manganese-dependent inorganic pyrophosphatase (type II PPase)","Cytoplasm","This sequence corresponds to the previously published GI:3403205, unknown, GI:2952533, a predicted exopolyphosphatase, and GI:7674163, a predicted manganese-dependent inorganic pyrophosphatase. Significant hits in gapped BLAST to Pyrophosphatases. Residues 1-310 are 93% similar to >gi7674163 as seen in S. mutans. Residues 2-310 are 92% similar to >gi14488513 as seen in S. mutans. Residues 1-309 are 76% similar to >gi15901378 as seen in S. pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1397 (1e-129).","

InterPro
IPR001667
Domain

Phosphoesterase, RecJ-like
PF01368	$\"[3-148]T$	DHH

InterPro
IPR004097
Domain

DHHA2
PF02833	$\"[182-308]T$	DHHA2

noIPR
unintegrated

unintegrated
G3DSA:3.90.1640.10	$\"[1-189]T$	G3DSA:3.90.1640.10
PTHR13734	$\"[1-255]T$	PTHR13734
PTHR13734:SF4	$\"[1-255]T$	PTHR13734:SF4
SSF64182	$\"[2-310]T$	SSF64182

","BeTs to 4 clades of COG1227COG name: ExopolyphosphataseFunctional Class: CThe phylogenetic pattern of COG1227 is am--y-V--b-----------Number of proteins in this genome belonging to this COG is 1","***** IPB001667 (DHH family) with a combined E-value of 5.8e-07. IPB001667A 11-24 IPB001667B 93-100 IPB001667C 284-292","Residues 72-307 are 91% similar to a (COMPLETE PROTEOME HYDROLASE MANGANESE) protein domain (PD003055) which is seen in PPAC_STRMU.Residues 3-68 are 62% similar to a (PROTEOME COMPLETE YSHC) protein domain (PD388139) which is seen in Q9CEM5_LACLA.Residues 4-67 are identical to a (PHOSPHO-HYDROLASE INORGANIC MANGANESE) protein domain (PD331117) which is seen in PPAC_STRMU.Residues 1-63 are 53% similar to a (PHOSPHO-HYDROLASE MANGANESE INORGANIC) protein domain (PD013785) which is seen in PPAC_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 13:38:53 2006","Fri Oct 25 13:08:37 2002","Thu Sep 14 13:38:53 2006","Wed Apr 10 15:28:46 2002","Tue Feb 5 22:41:44 2002","Tue Feb 5 22:41:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1537 is paralogously related (blast p-value < 1e-3) to SMu1942, a conserved hypothetical protein.","Thu Feb 7 14:04:27 2002","","No significant hits to the NCBI PDB database.","SMU.1687c","","Residues 1 to 148 (E-value = 7.9e-13) place SMu1537 in the DHH family which is described as DHH family (PF01368)Residues 182 to 308 (E-value = 2.2e-53) place SMu1537 in the DHHA2 family which is described as DHHA2 domain (PF02833)","Thu Sep 14 13:38:53 2006","","","Zyryanov AB, Shestakov AS, Lahti R, Baykov AA.Mechanism by which metal cofactors control substrate specificity in pyrophosphatase.Biochem J. 2002 Nov 1;367(Pt 3):901-906.PMID: 12169093Merckel MC, Fabrichniy IP, Salminen A, Kalkkinen N, Baykov AA, Lahti R, Goldman A. Crystal structure of Streptococcus mutans pyrophosphatase: a new fold for an old mechanism.Structure (Camb). 2001 Apr 4;9(4):289-97.PMID: 11525166","Young TW, Kuhn NJ, Wadeson A, Ward S, Burges D, Cooke GD.Bacillus subtilis ORF yybQ encodes a manganese-dependent inorganic pyrophosphatase with distinctive properties: the first of a new class of soluble pyrophosphatase?Microbiology. 1998 Sep;144 ( Pt 9):2563-71.PMID: 9782505 ","Thu Sep 14 13:38:53 2006","Wed Feb 27 10:09:30 2002","1","","","SMU.1687c","417" "SMu1538","1602731","1601466","1266","ATGCTTAAACGGTTATGGTTGATTTTGGGGCCAGTTTTCTGTGCCCTAGTTTTGGTTTTTTCTTTAATTATGTTCTATCCAGCTAAACATTTAAGTCATAATTATAATGAAGAAAAAAACGATGCTGTAGCTTTATCACCTAGTAGTTTTAAAAGTACCAATAAAAAAATGCGTGCATTGTCAGACAAAAGGCACCTCTTTGTCCCCTTTTTTGGTTCTAGTGAGTGGCAACGTATTGATAGTATGCATCCATCTGTTCTAGCAGAGCGTTATAATCGTTCTTATCGTCCCTATTTACTGGGACAAAAAGGGTCAACCTCTTTGTCACATTATTTTGGCATGCAGCAAATTGGTAATCAGATTAAAAATAAAAAGGCTGTCTATGTTATTTCTCCTCAGTGGTTCGTTCCAAAGGGGACAAGTCCTATCGCTTTTCAGCAGTATTTTAGTTCTGAACAATTAGCTGATTTTCTCTTAAATCAAACAGGAAGTACAGCGGATCGTTATGCAGCTAAACGTTTATTAGACATTAAACCGAGTTCGAATTTGCAAGGTATGATAAAAAAAATTGCGGCTGGTAAAACCTTAAATAGCTTTGATAGGGCAAGCCTGCGCCTTATTAAGAGTTTCTTGAAAAAAGAAGACGCTTTATTTGGAAGTCTGACCTTTAGTGATAATTATGAACGTCGTGTATTGCCGCATGTCAAAAAATTGCCCAAGCACTTTTCTTATGGAACCTTAAGTCAAATTGCTAGCAAAAATGGTCAAAGGTTAACAAAAACAAATCAATTTGAAATTAATGATCATTTTTATAATAAACGTATTAAAGGACAATTGAAAAGACTCAAAGGCTTCCAAAAGCAACTGTCTTATTTACAGTCTCCAGAATACAATGATTTACAGCTGGCGTTAACTCAATTAGCAAAGTCAAAGACCAAAGTCATATTTGTTATTCCGCCGGTTAATGCCAAATGGGTTGAATATACAGGTCTAAGCCAAGATATGTATCAAAAGACGGTTGAAAAAATAAAATATCAGTTACAGAGCCAAGGTTTTGATAACATTGCTGATTTATCAAAAAATGGTGATCAGCCTTATTTCATGCAGGATACCATTCATCTTGGTTGGAATGGTTGGCTGGCTTTTGATAAAGAGGTCAATCCCTTCTTATCCAAGAAACAGCTCCAACCGGCTTATAAGATTAATAATCACTTTTTAAGTAAAAAGTGGGCCACTTATACTGGTAATCCTTTTCAGTTTAAGTGA","10.80","34.35","48617","MLKRLWLILGPVFCALVLVFSLIMFYPAKHLSHNYNEEKNDAVALSPSSFKSTNKKMRALSDKRHLFVPFFGSSEWQRIDSMHPSVLAERYNRSYRPYLLGQKGSTSLSHYFGMQQIGNQIKNKKAVYVISPQWFVPKGTSPIAFQQYFSSEQLADFLLNQTGSTADRYAAKRLLDIKPSSNLQGMIKKIAAGKTLNSFDRASLRLIKSFLKKEDALFGSLTFSDNYERRVLPHVKKLPKHFSYGTLSQIASKNGQRLTKTNQFEINDHFYNKRIKGQLKRLKGFQKQLSYLQSPEYNDLQLALTQLAKSKTKVIFVIPPVNAKWVEYTGLSQDMYQKTVEKIKYQLQSQGFDNIADLSKNGDQPYFMQDTIHLGWNGWLAFDKEVNPFLSKKQLQPAYKINNHFLSKKWATYTGNPFQFK","1601482","For other 'dlt' genes see SMu1537 (dlt5); SMu1539 (dltC) , (dlt3); SMu1540 (dltB),(dlt2) and SMu1541 (dltA),(dlt1).","integral membrane protein","Membrane, Periplasm","This sequence corresponds to the previously published GI:3403204, unknown; GI:2952532, a predicted extramembranal protein; and GI:2981431, unknown in GenBank. Significant hits in gapped BLAST to extramembranal proteins. Residues 1-427 are 52% similar to >gi15904020 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1787 (1e-143).","

InterPro
IPR006998
Domain

DltD, C-terminal
PF04914	$\"[263-393]T$	DltD_C

InterPro
IPR006999
Domain

DltD, N-terminal
PF04915	$\"[37-99]T$	DltD_N

InterPro
IPR007002
Domain

DltD, central region
PF04918	$\"[100-262]T$	DltD_M

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-99 are identical to a (DLTD EXTRAMEMBRANAL PROTEOME COMPLETE) protein domain (PD023833) which is seen in O68578_STRMU.Residues 263-393 are 99% similar to a (DLTD EXTRAMEMBRANAL PROTEOME COMPLETE) protein domain (PD039136) which is seen in O68578_STRMU.Residues 100-253 are 99% similar to a (PROTEOME COMPLETE DLTD EXTRAMEMBRANAL) protein domain (PD304140) which is seen in O68578_STRMU.Residues 394-421 are identical to a (EXTRAMEMBRANAL) protein domain (PD121419) which is seen in O68578_STRMU.Residues 100-262 are 34% similar to a (DLTD EXTRAMEMBRANAL EXOPROTEIN PRECURSOR) protein domain (PD188062) which is seen in Q9RMN7_LACRH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 14:50:51 2006","Tue Sep 19 14:49:55 2006","Tue Sep 19 14:49:55 2006","Tue Feb 5 22:50:31 2002","","Tue Feb 5 22:50:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1538 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 10:12:41 2002","","No significant hits to the NCBI PDB database.","SMU.1688c","","Residues 37 to 99 (E-value = 2.4e-38) place SMu1538 in the DltD_N family which is described as DltD N-terminal region (PF04915)Residues 100 to 262 (E-value = 1.8e-95) place SMu1538 in the DltD_M family which is described as DltD central region (PF04918)Residues 263 to 393 (E-value = 8.7e-92) place SMu1538 in the DltD_C family which is described as DltD C-terminal region (PF04914)","Tue Sep 19 14:49:55 2006","","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)PUBMED 11029425Spatafora,G., Rohrer,K., Barnard,D. and Michalek,S.A Streptococcus mutans mutant that synthesizes elevated levels of intracellular polysaccharide is hypercariogenic in vivoInfect. Immun. 63 (7), 2556-2563 (1995)PubMed: 95310011Spatafora GA, Sheets M, June R, Luyimbazi D, Howard K, Hulbert R, Barnard D, el Janne M, Hudson MC.Regulated expression of the Streptococcus mutans dlt genes correlates with intracellular polysaccharide accumulation.J Bacteriol. 1999 Apr;181(8):2363-72.PMID: 10197997","Duwat P, Cochu A, Ehrlich SD, Gruss A.Characterization of Lactococcus lactis UV-sensitive mutants obtained by ISS1 transposition.J Bacteriol. 1997 Jul;179(14):4473-9.PMID: 9226255 Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W.Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation.J Biol Chem. 1995 Jun 30;270(26):15598-606.PMID: 7797557","Tue Sep 19 14:50:51 2006","Tue Feb 5 22:50:31 2002","1","","","SMU.1688c","478" "SMu1539","1602963","1602724","240","ATGGATATAAAATCAGAGGTTTTAAAAATTATTGATGAGCTTTTTATGGAAGATGTATCAGATATGATGGATGAAGATCTATTTGATGCAGGTGTTTTAGATAGCATGGGAACTGTTGAATTAATTGTTGAATTGGAAAATCATTTTGATATCACTGTTCCTGTTTCTGAATTTGGTCGTGATGATTGGAATACAGCCAATAAAATTATTGAGGGTATAACGGAGTTACGAAATGCTTAA","3.70","-15.76","8962","MDIKSEVLKIIDELFMEDVSDMMDEDLFDAGVLDSMGTVELIVELENHFDITVPVSEFGRDDWNTANKIIEGITELRNA","1602740","For other 'dlt' genes see SMu1537 (dlt5); SMu1538 (dltD) , (dlt4); SMu1540 (dltB),(dlt2) and SMu1541 (dltA),(dlt1).For other 'glg' genes see SMu1396 (glgP); SMu1397 (glgA); SMu1398 (glgD); SMu1399 (glgC); SMu1400 (glgB) and SMu1422 (glg). ","D-alanyl carrier protein","Cytoplasm","This sequence corresponds to the previously published GI:2981430, a predicted Glg3; GI:2961190, unknown; and GI:2952531, a predicted D-alanyl carrier protein in GenBank. Significant hits in gapped BLAST to D-alanyl carrier protein. Residues 1-79 are 88% similar to >gi15901984 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1788 (8e-35).","

InterPro
IPR003230
Family

D-alanyl carrier protein
PD015103	$\"[7-76]T$	DLTC_STRMU_O70055;
TIGR01688	$\"[4-75]T$	dltC: D-alanyl carrier protein

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PS50075	$\"[3-58]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[3-77]T$	no description

","BeTs to 10 clades of COG0236COG name: Acyl carrier proteinFunctional Class: IThe phylogenetic pattern of COG0236 is ----yqVceBRhUjgpolinxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 1-77 are identical to a (CARRIER D-ALANYL PHOSPHOPANTETHEINE DCP) protein domain (PD015103) which is seen in O70055_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 26 18:08:08 2006","Tue Feb 5 22:58:39 2002","Tue Sep 19 11:54:03 2006","Wed Apr 10 15:32:57 2002","","Tue Feb 5 22:58:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1539 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 10:14:47 2002","","No significant hits to the NCBI PDB database.","SMU.1689c","","No significant hits to the Pfam 11.0 database","Tue Feb 5 22:58:39 2002","","","Spatafora,G., Rohrer,K., Barnard,D. and Michalek,S.A Streptococcus mutans mutant that synthesizes elevated levels of intracellular polysaccharide is hypercariogenic in vivoInfect. Immun. 63 (7), 2556-2563 (1995)PubMed: 7790069Spatafora GA, Sheets M, June R, Luyimbazi D, Howard K, Hulbert R, Barnard D, el Janne M, Hudson MC.Regulated expression of the Streptococcus mutans dlt genes correlates with intracellular polysaccharide accumulation.J Bacteriol. 1999 Apr;181(8):2363-72.PMID: 10197997Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)PUBMED 11029425","Poyart C, Lamy MC, Boumaila C, Fiedler F, Trieu-Cuot P.Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system.J Bacteriol. 2001 Nov;183(21):6324-34.PMID: 11591677Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W.Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation.J Biol Chem. 1995 Jun 30;270(26):15598-606.PMID: 7797557 ","Tue Sep 19 11:54:03 2006","Tue Oct 29 12:17:09 2002","1","","","SMU.1689c","978" "SMu1540","1604240","1602978","1263","ATGATTGATTTTTTCAAGAATCTTCCTCACTTAGAAGCTTATGGAAATCCTCAATATTTTTTCTATATTATTTTGGCTGTCTTACCAATTTTTATAGGCCTCTTTTTTAAGAAACGCTTTCCTCTTTATGAGGCTTTTGTTAGTCTGATTTTTATTGTTTTAATGTTGACAGGTGAAAAGTCGCATCAAATCTTTGCCTTGTTTTTCTATATCATTTGGCAAATTTTCTGTGTCTATAGTTATAAATTTTATAGAAAATCACGGGATAATAAGTGGATTTTTTATCTTCATGTCTTCATGTCTATCTTACCTTTATCTTTGGTAAAGATTACTCCTGCGATTTGGACAAATCAACAATCTTTATTTGGTTTTTTGGGTATATCCTATCTTACCTTTCGTTCAGTAGGTATGATTATGGAAATGCGAGACGGTGTTCTCACGTCATTTACATTTTGGGAATTTATCCGTTTTATGCTGTTTATGCCCACTTTTTCAAGTGGGCCCATTGATCGTTTCAGAAGATTTAATGATGATTATGAGAAGATTCCTGATAAAGATGAATTGCTAGATATGTTGGAACAATCTGTTCACTATATCATGCTTGGTTTTTTCTATAAGTTTGTTTTAGCGCAAATATTGGGAACAATGATTTTACCGGGTTTGAAAGAAATGGCCTTGCAAAAAGGTGGTTGGTTCAATTGGCCGACTTTAGGAGTCATGTATGTTTATGGCCTAGACTTATTTTTTGACTTTGCTGGTTATTCAATGTTTGCCATAGCTATCTCTAACTTTATGGGAATCAAGAGTCCAACTAATTTTAACCAACCGTTTAAATCACAAGATTTGAAGGAATTTTGGAATCGCTGGCATATGAGTTTGTCTTTTTGGTTTAGAGACTTTGTTTTTATGCGTCTTGTCAAAGTTTTAGTCAAAAATAAGGTCTTCAAAAATCGCAATGTTACATCAAGTGTTGCTTATATTGTGAATATGCTGATTATGGGATTTTGGCATGGCGTAACTTGGTATTATATTACCTATGGTCTATTTCACGGTGTCGGTTTAGTACTCAACGACGCTTGGCTTCGTAAAAAGAAAAGACTGAACAAAGAGAGAAAAGCAAAGAATTTATCACCTTTGCCAGAAAATGGCTGGACAAGAGCGTTAGGTATTGTCATTACCTTTAATGTTGTCATGTTATCATTTCTGATTTTCTCAGGATTCTTAAATGACTTGTGGTTTGCAGATCAATTATCAAAGAAATAA","10.50","18.64","49931","MIDFFKNLPHLEAYGNPQYFFYIILAVLPIFIGLFFKKRFPLYEAFVSLIFIVLMLTGEKSHQIFALFFYIIWQIFCVYSYKFYRKSRDNKWIFYLHVFMSILPLSLVKITPAIWTNQQSLFGFLGISYLTFRSVGMIMEMRDGVLTSFTFWEFIRFMLFMPTFSSGPIDRFRRFNDDYEKIPDKDELLDMLEQSVHYIMLGFFYKFVLAQILGTMILPGLKEMALQKGGWFNWPTLGVMYVYGLDLFFDFAGYSMFAIAISNFMGIKSPTNFNQPFKSQDLKEFWNRWHMSLSFWFRDFVFMRLVKVLVKNKVFKNRNVTSSVAYIVNMLIMGFWHGVTWYYITYGLFHGVGLVLNDAWLRKKKRLNKERKAKNLSPLPENGWTRALGIVITFNVVMLSFLIFSGFLNDLWFADQLSKK","1602994","For other 'dlt' genes see SMu1537 (dlt5); SMu1538 (dltD) , (dlt4); SMu1539 (dlt3),(dltC) and SMu1541 (dltA),(dlt1).","integral membrane protein, D-alanyl transfer","Membrane, Cytoplasm","This sequence corresponds to the previously published GI:2952530, a predicted integral membrane protein; GI:2981429, a predicted Glg2; and GI:2961189, unknown in GenBank. Significant hits in gapped BLAST to D-alanine transfer proteins. Residues 1-413 are 65% similar to >gi15904022 and >gi15901985 as seen in S. pneumoniae. Residues 1-413 are 54% similar to >gi15675260 as seen in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1789 (1e-163).","

InterPro
IPR004299
Family

Membrane bound O-acyl transferase, MBOAT
PF03062	$\"[108-400]T$	MBOAT

InterPro
IPR014698
Family

D-alanyl transfer protein DltB
PIRSF500216	$\"[11-414]T$	DltB

noIPR
unintegrated

unintegrated
PIRSF016636	$\"[18-419]T$	AlgI_DltB

","BeTs to 4 clades of COG1696COG name: Predicted membrane protein involved in D-alanine exportFunctional Class: MThe phylogenetic pattern of COG1696 is ----Y----b--u----l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 125-255 are 32% similar to a (PROTEOME ALGI COMPLETE ALGINATE) protein domain (PD024825) which is seen in Q9JZ64_NEIMB.Residues 351-419 are 76% similar to a (PROTEOME COMPLETE MEMBRANE PEPTIDOGLYCAN) protein domain (PD406761) which is seen in O70067_STRMU.Residues 14-207 are identical to a (MEMBRANE INTEGRAL TRANSPORT TRANSMEMBRANE) protein domain (PD014253) which is seen in O70067_STRMU.Residues 240-350 are 84% similar to a (PROTEOME COMPLETE ALGI MEMBRANE) protein domain (PD156146) which is seen in O68577_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 14:58:23 2006","Tue Sep 19 14:56:26 2006","Tue Sep 19 14:56:26 2006","Wed Apr 10 15:25:21 2002","","Tue Feb 5 23:08:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1540 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 10:17:12 2002","","No significant hits to the NCBI PDB database.","SMU.1690c","","Residues 108 to 400 (E-value = 2.8e-103) place SMu1540 in the MBOAT family which is described as MBOAT family (PF03062)","Tue Feb 5 23:08:23 2002","","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)PUBMED 11029425Spatafora,G., Rohrer,K., Barnard,D. and Michalek,S.A Streptococcus mutans mutant that synthesizes elevated levels of intracellular polysaccharide is hypercariogenic in vivoInfect. Immun. 63 (7), 2556-2563 (1995)PubMed: 95310011Spatafora GA, Sheets M, June R, Luyimbazi D, Howard K, Hulbert R, Barnard D, el Janne M, Hudson MC.Regulated expression of the Streptococcus mutans dlt genes correlates with intracellular polysaccharide accumulation.J Bacteriol. 1999 Apr;181(8):2363-72.PMID: 10197997","Poyart C, Lamy MC, Boumaila C, Fiedler F, Trieu-Cuot P.Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system.J Bacteriol. 2001 Nov;183(21):6324-34.PMID: 11591677 Clemans DL, Kolenbrander PE, Debabov DV, Zhang Q, Lunsford RD, Sakone H, Whittaker CJ, Heaton MP, Neuhaus FC.Insertional inactivation of genes responsible for the D-alanylation of lipoteichoic acid in Streptococcus gordonii DL1 (Challis) affects intrageneric coaggregations.Infect Immun. 1999 May;67(5):2464-74.PMID: 10225909Spatafora GA, Sheets M, June R, Luyimbazi D, Howard K, Hulbert R, Barnard D, el Janne M, Hudson MC.Regulated expression of the Streptococcus mutans dlt genes correlates with intracellular polysaccharide accumulation.J Bacteriol. 1999 Apr;181(8):2363-72.PMID: 10197997","Tue Sep 19 14:56:26 2006","Tue Oct 29 12:12:46 2002","1","","","SMU.1690c","479" "SMu1541","1605787","1604237","1551","ATGGCTAATAAAAAAATAAAAGATATGATTGCAACAATTGAAAATTTTGCTCAAGAACAGGCAGAATTTCCGGTTTATAATATTTTAGGAGAAATCCATACCTATGGAGAATTAAAAGCTGATTCTGATTCGCTTGCAGCTCATCTTGATCAGTTAGATTTAACAGCAAAATCACCAGTAGTTGTCTTTGGAGGACAGGAATATGCCATGCTGGCTAGTTTTGTTGCTCTGACAAAATCAGGGCATGCCTATATTCCTATTGATCATCATTCAGCCTTAGAACGTATTGAGGCTATTTTAGAGGTAGCAGAGCCAAGTTTAGTTATTGCTGTTGATGATTTCCCAATTGACAATCTTCAAGTCCCAGTAATTCAGTATAGTCAATTAGAAGAGATTTTTAAACAAAAGCTATCTTATCAAATCAATCATGCGGTTAAGGGAGATGATACCTACTATATCATCTTTACTTCAGGGACAACTGGTAAACCTAAAGGAGTACAGATTTCACATGACAATCTGCTTAGTTTTACTAATTGGATGATTAATGCAGAAGCTTTTGCAACACCTCATAGGCCGCAAATGCTGGCACAACCGCCTTACTCTTTTGATTTATCAGTGATGTACTGGGCGCCAACATTGGCTTTAGGTGGAACCCTTTTTGCTCTTCCTAAAGAAATAACTGCAGATTTCAAACAATTATTTACAACTATTAACCAATTACCCATTGGTGTGTGGACATCAACACCTTCCTTTGTTGATATGGCTATGCTGTCAGATGACTTTAATGCACAGCAATTGCCTCATTTAACTCATTTCTATTTTGACGGAGAAGAGTTGACGGTTAAGACGGCTAAAAAATTGCGTCAGCGTTTTCCGCAAGCAAGAATTGTCAACGCTTATGGGCCAACAGAAGCAACTGTTGCTTTATCAGCTTTGGCTGTCACTGATAAAATGCTTGAAACATGCAAACGTCTGCCAATTGGCTATACAAAACCAGATTCGCCAACCTTTATTATTGATGAGTCAGGTCATAAACTGGCAAATGGTCAGCAAGGAGAGATTATTGTTTCCGGTCCGGCAGTCTCTAAGGGGTATCTCAATAATCCTGAACGAACAGCAGCAGCTTTCTTTGAATTTGAAGGTTTGCCAGCTTATCATACTGGTGATTTGGGAAGTATGACAGATGAAGGTCTCTTGCTCTATGGCGGTCGTATGGATTTTCAGATTAAATTCAATGGCTATCGTATTGAGTTGGAAGAAGTCTCTCAAAATCTTAACAAATCGCAATATATCGCATCTGCTGTAGCTGTTCCCCGTTATAATAAAGACCATAAGGTGCAAAATCTTTTGGCTTATGTTGTCTTAAAAGATGGTGTAGAAGAGCAATTTGAGAGAGCACTTGACATTACCAAAGCTATTAAGGCTGATTTGCAAGATGTTATGATGGATTACATGATGCCTTCTAAGTTTTTGTACCGTAAAGATTTACCTTTAACACCTAATGGTAAAATTGATATTAAAGGTTTGATGAGTGAGGTAAACAAAAAATGA","5.20","-13.88","57550","MANKKIKDMIATIENFAQEQAEFPVYNILGEIHTYGELKADSDSLAAHLDQLDLTAKSPVVVFGGQEYAMLASFVALTKSGHAYIPIDHHSALERIEAILEVAEPSLVIAVDDFPIDNLQVPVIQYSQLEEIFKQKLSYQINHAVKGDDTYYIIFTSGTTGKPKGVQISHDNLLSFTNWMINAEAFATPHRPQMLAQPPYSFDLSVMYWAPTLALGGTLFALPKEITADFKQLFTTINQLPIGVWTSTPSFVDMAMLSDDFNAQQLPHLTHFYFDGEELTVKTAKKLRQRFPQARIVNAYGPTEATVALSALAVTDKMLETCKRLPIGYTKPDSPTFIIDESGHKLANGQQGEIIVSGPAVSKGYLNNPERTAAAFFEFEGLPAYHTGDLGSMTDEGLLLYGGRMDFQIKFNGYRIELEEVSQNLNKSQYIASAVAVPRYNKDHKVQNLLAYVVLKDGVEEQFERALDITKAIKADLQDVMMDYMMPSKFLYRKDLPLTPNGKIDIKGLMSEVNKK","1604253","For other 'dlt' genes see SMu1537 (dlt5); SMu1538 (dltD) , (dlt4); SMu1539 (dlt3),(dltC) and SMu1540 (dltB),(dlt2).Several iterations of Psi-BLAST favor peptide synthetases akin to the paralogous synthetases -- gramacidin, bacitracin, etc. ","D-alanine-D-alanyl carrier protein ligase","Cytoplasm","This sequence corresponds to the previously published GI:2952529, a predicted D-alanine-D-alanyl carrier protein ligase; GI:2981428, a predicted Glg1; and GI:2961188, unknown in GenBank. Significant hits in gapped BLAST to D-alanine-D-alanyl carrier protein ligase. Residues 1-516 are 79% similar to >gi15901986 and >gi15904023 as seen in S. pneumoniae. Residues 6-516 are 71% similar to >gi15675261 as seen in S. pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1790 (0.0).","

InterPro
IPR000873
Domain

AMP-dependent synthetase and ligase
PR00154	$\"[148-159]T$ $\"[160-168]T$	AMPBINDING
PF00501	$\"[34-436]T$	AMP-binding
PS00455	$\"[153-164]T$	AMP_BINDING

InterPro
IPR010071
Domain

Amino acid adenylation
TIGR01733	$\"[34-436]T$	AA-adenyl-dom

InterPro
IPR010072
Family

D-alanine-activating enzyme
PTHR11968:SF34	$\"[9-513]T$	D_ala_DACP_lig
TIGR01734	$\"[8-515]T$	D-ala-DACP-lig

noIPR
unintegrated

unintegrated
G3DSA:2.30.38.10	$\"[325-401]T$	G3DSA:2.30.38.10
PTHR11968	$\"[9-513]T$	PTHR11968
SSF56801	$\"[8-516]T$	SSF56801

","BeTs to 5 clades of COG0318COG name: Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases IIFunctional Class: IThe phylogenetic pattern of COG0318 is A-t-Y---EBRh------inxNumber of proteins in this genome belonging to this COG is 2","***** IPB000873 (AMP-dependent synthetase and ligase) with a combined E-value of 1.1e-09. IPB000873A 155-170","Residues 147-249 are 30% similar to a (78-11) protein domain (PD259370) which is seen in Q54356_STRLN.Residues 148-250 are 32% similar to a (MCYB PHOSPHOPANTETHEINE) protein domain (PD396892) which is seen in Q9S1A8_MICAE.Residues 338-395 are 50% similar to a (LIGASE PROTEOME COMPLETE METABOLISM ACYL-COA) protein domain (PD001741) which is seen in Q9S391_LISMO.Residues 349-397 are 55% similar to a (LIGASE SYNTHETASE COMPLETE PROTEOME) protein domain (PD007428) which is seen in DLTA_LACCA.Residues 282-332 are 50% similar to a (LIGASE CARRIER D-ALANINE-D-ALANYL DLTA) protein domain (PD204178) which is seen in Q9X2N4_STAXY.Residues 34-117 are 98% similar to a (LIGASE 6.3.2.- ENZYME CARRIER) protein domain (PD204196) which is seen in DLTA_STRMU.Residues 1-33 are 93% similar to a (LIGASE ALANYL 6.3.2.- CARRIER) protein domain (PD371198) which is seen in DLTA_STRMU.Residues 144-176 are 90% similar to a (SYNTHETASE PHOSPHOPANTETHEINE LIGASE) protein domain (PD296195) which is seen in DLTA_LACCA.Residues 290-346 are 49% similar to a (SYNTHETASE PHOSPHOPANTETHEINE LIGASE) protein domain (PD000107) which is seen in DLTA_LACCA.Residues 403-460 are identical to a (LIGASE SYNTHETASE PHOSPHOPANTETHEINE) protein domain (PD000081) which is seen in DLTA_STRMU.Residues 176-281 are 85% similar to a (LIGASE CARRIER D-ALANINE-D-ALANYL ENZYME) protein domain (PD204220) which is seen in DLTA_STRMU.Residues 148-250 are 33% similar to a (PHOSPHOPANTETHEINE REDUCTASE) protein domain (PD034004) which is seen in Q9RNB0_MICAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 09:12:27 2006","Thu Aug 24 09:12:27 2006","Thu Aug 24 09:12:27 2006","Tue Mar 5 08:59:00 2002","Tue Feb 5 23:18:13 2002","Tue Feb 5 23:18:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1541 is paralogously related (blast p-value < 1e-3) to SMu1225, SMu1222 and SMu1223, predicted bacitracin synthetases, SMu1224,a predicted gramicidin S synthetase, and SMu1228, a predicted peptide synthetase.","Tue Mar 5 09:09:24 2002","Thu Aug 24 09:12:27 2006","pdb1AMUB Chain B, Phenylalanine Activating Domain Of Gramicid... 176 7e-045","SMU.1691c","","Residues 34 to 436 (E-value = 1.5e-112) place SMu1541 in the AMP-binding family which is described as AMP-binding enzyme (PF00501)","Tue Feb 5 23:18:13 2002","","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)PUBMED 11029425Spatafora,G., Rohrer,K., Barnard,D. and Michalek,S.A Streptococcus mutans mutant that synthesizes elevated levels of intracellular polysaccharide is hypercariogenic in vivoInfect. Immun. 63 (7), 2556-2563 (1995)PubMed: 7790069Spatafora GA, Sheets M, June R, Luyimbazi D, Howard K, Hulbert R, Barnard D, el Janne M, Hudson MC.Regulated expression of the Streptococcus mutans dlt genes correlates with intracellular polysaccharide accumulation.J Bacteriol. 1999 Apr;181(8):2363-72.PMID: 10197997","Poyart C, Lamy MC, Boumaila C, Fiedler F, Trieu-Cuot P.Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system.J Bacteriol. 2001 Nov;183(21):6324-34.PMID: 11591677Clemans DL, Kolenbrander PE, Debabov DV, Zhang Q, Lunsford RD, Sakone H, Whittaker CJ, Heaton MP, Neuhaus FC.Insertional inactivation of genes responsible for the D-alanylation of lipoteichoic acid in Streptococcus gordonii DL1 (Challis) affects intrageneric coaggregations.Infect Immun. 1999 May;67(5):2464-74.PMID: 10225909 Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W.Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation.J Biol Chem. 1995 Jun 30;270(26):15598-606.PMID: 7797557 ","Tue Oct 29 13:29:28 2002","Tue Oct 29 12:10:18 2002","1","","","SMU.1691c","184" "SMu1542","1607396","1606605","792","ATGATAGAAAAAGTTGACTACGAAAAAGTAACAGGACTTGTTAATTCTACAGAATCTTTTGGGTCTGTAGACGGACCTGGTATACGCTTTGTTGTTTTTATGCAAGGGTGCCAAATGCGTTGTCAATATTGCCACAATCCTGATACTTGGGCAATGAAGAATGATAGAGCAACAGAAAGGACTGCAGGAGATGTCTTTAAAGAAGCTTTACGTTTTAAAGATTTTTGGGGAGATACAGGAGGTATTACTGTTTCTGGTGGTGAAGCAACGCTCCAGATGGATTTTTTAATTGCCCTCTTTTCTTTAGCAAAAGAAAAGGGAATTCATACGACCTTGGATACCTGTGCTCTGACTTTTAGAAACACACCAAAATATCTTGAAAAATATGAAAAGTTAATGGCTGTCACTGATTTAGTATTGTTAGATATTAAAGAGATTAATCCTGACCAACATAAAATTGTCACTGGTCATAGCAATAAAACTATTTTAGCTTGTGCGCGTTATTTATCTGATATTGGAAAACCTGTTTGGATTCGCCATGTCTTAGTCCCTGGTCTGACTGATCGGGATGAAGACTTAATAAAGTTGGGTGAGTATGTCAAAACACTGAAGAATGTTCAACGGTTTGAAATTCTTCCTTATCATACAATGGGTGAATTCAAATGGCGTGAATTAGGGATTCCTTATCCTTTGGAAGGTGTTAAACCGCCAACACCAGATCGTGTGCGCAATGCTAAAAAGTTAATGCATACGGAAACATATGAAGAATATAAAAAGAGGATTAATCATTAA","7.80","2.70","30136","MIEKVDYEKVTGLVNSTESFGSVDGPGIRFVVFMQGCQMRCQYCHNPDTWAMKNDRATERTAGDVFKEALRFKDFWGDTGGITVSGGEATLQMDFLIALFSLAKEKGIHTTLDTCALTFRNTPKYLEKYEKLMAVTDLVLLDIKEINPDQHKIVTGHSNKTILACARYLSDIGKPVWIRHVLVPGLTDRDEDLIKLGEYVKTLKNVQRFEILPYHTMGEFKWRELGIPYPLEGVKPPTPDRVRNAKKLMHTETYEEYKKRINH","1606621","For other 'pfl' genes see SMu0363 (pfl); SMu0444 (pflC) and SMu0446 (pfl-2), (pfl).","pyruvate-formate lyase activating enzyme","Cytoplasm","This sequence corresponds to the previously published GI:3986294, GI:2952528, and GI:6093702, predicted Pyruvate formate-lyase activating enzymes in GenBank. Significant hits in gapped BLAST to Pyruvate-formate lyase activating enzyme. Residues 3-262 are 77% similar to >gi|15903833 and >gi|15901799 as seen in S. pneumoniae. Residues 4-263 are 72% similar to >gi|14141682 as seen in S. bovis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1398 (1e-111).","

InterPro
IPR001989
Domain

Radical-activating enzyme
PS01087	$\"[25-46]T$	RADICAL_ACTIVATING

InterPro
IPR006638
Domain

Elongator protein 3/MiaB/NifB
SM00729	$\"[27-247]T$	Elp3

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[31-197]T$	Radical_SAM

InterPro
IPR012838
Family

Pyruvate formate-lyase activating
TIGR02493	$\"[13-252]T$	PFLA

noIPR
unintegrated

unintegrated
SSF102114	$\"[26-235]T$	SSF102114

","BeTs to 6 clades of COG1180COG name: Pyruvate-formate lyase-activating enzymeFunctional Class: OThe phylogenetic pattern of COG1180 is AMTk-qV-E-rH---------Number of proteins in this genome belonging to this COG is 2","***** IPB001989 (Radical activating enzymes) with a combined E-value of 7e-30. IPB001989A 23-50 IPB001989B 81-92 IPB001989C 139-144","Residues 50-81 are identical to a (ENZYME LYASE ACTIVATING FORMATE-LYASE) protein domain (PD409015) which is seen in PFLA_STRMU.Residues 10-49 are 72% similar to a (ACTIVATING ANAEROBIC REDUCTASE ENZYME) protein domain (PD016381) which is seen in Q9CPG4_PASMU.Residues 212-254 are 81% similar to a (ENZYME ACTIVATING PYRUVATE LYASE) protein domain (PD266006) which is seen in Q9CEM4_LACLA.Residues 82-211 are identical to a (ENZYME PYRUVATE ACTIVATING LYASE) protein domain (PD385927) which is seen in PFLA_STRMU.Residues 64-193 are 29% similar to a (ACTIVATING ENZYME PYRUVATE IRON-SULFUR) protein domain (PD004351) which is seen in O87941_THAAR.Residues 82-211 are 41% similar to a (COMPLETE PROTEOME COFACTOR BIOSYNTHESIS MOLYBDENUM) protein domain (PD000790) which is seen in PFLA_ECOLI.Residues 8-49 are identical to a (ENZYME ACTIVATING PYRUVATE IRON-SULFUR) protein domain (PD004758) which is seen in PFLA_STRMU.Residues 239-263 are identical to a (ENZYME FORMATE-LYASE PYRUVATE IRON-SULFUR) protein domain (PD368282) which is seen in PFLA_STRMU.Residues 88-203 are 43% similar to a (PROTEOME COMPLETE PYRUVATE ACTIVATING) protein domain (PD385798) which is seen in Q9KQX8_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 08:13:48 2002","Tue Feb 5 23:26:28 2002","Thu Oct 17 08:13:48 2002","Wed Apr 10 15:37:51 2002","Tue Feb 5 23:26:28 2002","Tue Feb 5 23:26:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1542 is paralogously related (blast p-value < 1e-3) to SMu0444, a predicted pyruvate formate-lyase activating enzyme and SMu1879, a predicted anaerobic ribonucleotide reductase activating protein.","Thu Feb 7 14:11:24 2002","","No significant hits to the NCBI PDB database.","SMU.1692c","","Residues 31 to 197 (E-value = 1.5e-33) place SMu1542 in the Radical_SAM family which is described as Radical SAM superfamily (PF04055)","Tue Feb 5 23:26:28 2002","","","Yamamoto,Y., Sato,Y., Takahashi-Abbe,S., Takahashi,N. and Kizaki,H.Characterization of the streptococcus mutans pyruvate formate-lyase (PFL)-activating enzyme gene by complementary reconstitution of the In vitro PFL-reactivating systemInfect. Immun. 68 (8), 4773-4777 (2000)PubMed: 20359379Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)PUBMED 11029425","","Wed Feb 27 10:30:53 2002","","1","","","SMU.1692c","418" "SMu1543","1608808","1607471","1338","ATGGAAGACCCCGGTAGCCAGTCCTTGATCTTACAATTTTTATTATTACTGATTTTAACGCTTTGCAATGCTTTTTTCTCAGCTACTGAAATGGCTCTTGTATCTCTTAATCGTGCACGCGTTGAACAAAAGGCTGAAGAGGGCGAAAAAAAGTATATCCGTCTGCTAAAAGTTTTGGAAAATCCTAATAATTTTCTATCAACCATTCAGGTTGGTATTACTCTTATTACCCTTTTATCCGGAGCGAGTTTGGCAGATTCTTTAGGGCGTGAAATTGCTGTTTGGTTTGGCAATTCAGCTACTGCCAGAACGGCAGGAAGTCTTATTTCTTTAGCTTTTTTGACCTATATTTCTATTGTTTTGGGTGAATTGTATCCTAAACGTATTGCTATGAATCTCAAGGAAAATTTAGCTGTGCTGTCAGCACCTGTTATTATTTTTCTTGGCAAAGTGGTTAGCCCTTTTGTTTGGCTGCTTTCGGTCTCAACAAATCTATTAAGTCGCCTCACTCCTATGACCTTTGATGATGCCGATGAGAAAATGACCCGTGATGAAATTGAATACATGTTGACAAACAGTGAAGAGACTCTAGATGCTGATGAAATTGAAATGCTGCAAGGTGTCTTTTCACTAGATGAATTGATGGCACGTGAAGTGATGGTTCCTCGTACAGATGCTTTTATGGTGGATATTAATGATGATTCTAGTGATATTATCCAAACCATTCTCAATGAAAGATTTTCGCGGATTCCTGTTTACGATGATGATAAAGATAAGATTATTGGAATCATTCATACTAAAAATTTATTGAATGCTGGTTTCAAGGAAGGTTTTGATCACATCAATCTTCGCCGTATTTTGCAAGAGCCGCTTTTTGTACCAGAAACTATTGTTGTAAATGACCTTTTGACCGCTTTAAAAAATACCCAAAATCAGATGGCTATCCTACTTGATGAGTATGGCGGTGTGGCAGGTCTTGTCACCTTAGAAGACTTATTAGAAGAAATTGTTGGTGAAATTGATGATGAGACAGACAAAACAGCCATTTCTGTTCGTGAAATTGCAGATAATACCTATATTGTTTTGGGAACAATGACACTTAATGATTTTAATGAGTACTTTGAAACTGACCTTGAAAGTGATAATGTTGATACGATTGCTGGTTTTTATCTGACTGGTGTCGGAACAATTCCAAGTCAAGAAGAAAAAGAACACTTTGAAGTAGAGAGTAATGGCAAACACCTTGAACTGATTAATGATAAAGTTAAGGATGGTCGGGTTACCAAACTGAAGATTCTCGTTTCAGAGGTTGAAGAAAAGGAAGATGAAAAAGACTAA","4.20","-39.01","49779","MEDPGSQSLILQFLLLLILTLCNAFFSATEMALVSLNRARVEQKAEEGEKKYIRLLKVLENPNNFLSTIQVGITLITLLSGASLADSLGREIAVWFGNSATARTAGSLISLAFLTYISIVLGELYPKRIAMNLKENLAVLSAPVIIFLGKVVSPFVWLLSVSTNLLSRLTPMTFDDADEKMTRDEIEYMLTNSEETLDADEIEMLQGVFSLDELMAREVMVPRTDAFMVDINDDSSDIIQTILNERFSRIPVYDDDKDKIIGIIHTKNLLNAGFKEGFDHINLRRILQEPLFVPETIVVNDLLTALKNTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKTAISVREIADNTYIVLGTMTLNDFNEYFETDLESDNVDTIAGFYLTGVGTIPSQEEKEHFEVESNGKHLELINDKVKDGRVTKLKILVSEVEEKEDEKD","1607487","","uncharacterized hemolysin","Membrane, Cytoplasm, Extracellular","This sequence corresponds to the previously published GI:2952527, a predicted hemolysin in GenBank. Significant hits in gapped BLAST to hemolysin. Residues 1-433 are 90% similar to >gi|2952527 as seen in S. mutans. Residues 1-433 are 71% similar to >gi|15674525 as seen in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1399 (1e-178).","

InterPro
IPR000644
Domain

Cystathionine-beta-synthase
PF00571	$\"[220-337]T$	CBS
SM00116	$\"[225-274]T$ $\"[289-337]T$	CBS

InterPro
IPR002550
Domain

Protein of unknown function DUF21
PF01595	$\"[11-201]T$	DUF21

InterPro
IPR005170
Domain

Transporter-associated region
PF03471	$\"[352-436]T$	CorC_HlyC

noIPR
unintegrated

unintegrated
PTHR22777	$\"[45-443]T$	PTHR22777

","BeTs to 11 clades of COG1253COG name: Uncharacterized CBS domain-containing proteinsFunctional Class: RThe phylogenetic pattern of COG1253 is -----QVCEBRHuj--OLINXNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 354-432 are identical to a (PROTEOME COMPLETE HEMOLYSIN CBS) protein domain (PD005611) which is seen in O68574_STRMU.Residues 293-345 are 77% similar to a (COMPLETE PROTEOME HEMOLYSIN CBS) protein domain (PD002327) which is seen in Q9CEM3_LACLA.Residues 22-185 are 27% similar to a (PROTEOME PA3748 COMPLETE) protein domain (PD263151) which is seen in Q9HXP6_PSEAE.Residues 204-270 are 83% similar to a (COMPLETE PROTEOME DOMAIN CBS HEMOLYSIN REPEAT) protein domain (PD004826) which is seen in O68574_STRMU.Residues 293-338 are identical to a (DOMAIN REPEAT CBS TRANSMEMBRANE) protein domain (PD335406) which is seen in O68574_STRMU.Residues 23-203 are 36% similar to a (COMPLETE PROTEOME HEMOLYSIN DOMAIN) protein domain (PD102496) which is seen in Y260_SYNY3.Residues 283-339 are 47% similar to a (PROTEOME COMPLETE HEMOLYSIN) protein domain (PD172934) which is seen in O83906_TREPA.Residues 25-202 are 24% similar to a (PROTEOME COMPLETE CT257 TC0528) protein domain (PD211208) which is seen in Q9Z8E8_CHLPN.Residues 27-201 are 24% similar to a (PROTEOME DOMAIN SLL1254 COMPLETE) protein domain (PD235123) which is seen in YC54_SYNY3.Residues 312-345 are 67% similar to a (PROTEOME DOMAIN COMPLETE RV1842C) protein domain (PD411228) which is seen in YI42_MYCTU.Residues 23-203 are 93% similar to a (COMPLETE PROTEOME INTEGRAL MEMBRANE) protein domain (PD002457) which is seen in O68574_STRMU.Residues 275-347 are 34% similar to a (DOMAIN FFH-GRPE CBS CORB) protein domain (PD414453) which is seen in YFJD_ECOLI.Residues 289-342 are 38% similar to a (PROTEOME DOMAIN TRANSMEMBRANE COMPLETE) protein domain (PD274712) which is seen in Q9PDU9_XYLFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 10:31:50 2002","Wed Feb 27 10:31:50 2002","Thu Oct 17 08:12:59 2002","Thu Oct 17 08:12:59 2002","","Thu Feb 7 14:17:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1543 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 10:31:50 2002","","No significant hits to the NCBI PDB database.","SMU.1693c","","Residues 11 to 201 (E-value = 5.9e-74) place SMu1543 in the DUF21 family which is described as Domain of unknown function DUF21 (PF01595)Residues 220 to 274 (E-value = 7e-12) place SMu1543 in the CBS family which is described as CBS domain (PF00571)Residues 284 to 337 (E-value = 3.1e-05) place SMu1543 in the CBS family which is described as CBS domain (PF00571)Residues 352 to 436 (E-value = 2.3e-22) place SMu1543 in the CorC_HlyC family which is described as Transporter associated domain (PF03471)","Thu Feb 7 14:17:28 2002","","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)PUBMED 11029425","","Wed Feb 27 10:31:50 2002","","1","","","SMU.1693c","149" "SMu1544","1609938","1608844","1095","ATGTTTAAGAGTAGTAAATTGTTTTTCTGGACAGTAGAAATTTTACTGGTCACTTTAATTCTTTTTATCTGGCGGCAAATGGGAAGTATCTTTAATCCTTTTTTCAGTGTTGCTAAAACGTTTTTTCTTCCTTTTTTATTGGGAGGTTTTCTTTATTATATTACTAATCCTATTGTCACTTTTTTAGAAAACCGTTTTAAAATTAAGCGTATTTGGGGGATCACTCTTATTTTTGCTGTATTGCTTTCCTTGCTGGTTTTTTCTATTACCAGTCTGATTCCCAATTTGATTAATCAGCTAACAGATCTTATTTCAGCCAGCCAAAATATTTATGTGGGTTTGCAGGATTTATTCAATGAATGGAAAAGCAATCCTGCCTTTAAAAATATTGATATCCCTGTTCTTTTAAAACAGTTCAATTTATCTTATGTTGATATTTTGACAAATGTTTTGGATAGCGTGACAGTTAGTGTCTCAAGTATTGTTTATATGATTACAAATACGGTGATGATTCTGGTTCTTACACCCGTTATTCTTTTTTATCTCCTCAAGGACAAAGATGGTTTAATGCCCATGTTAGATCGTACTATATTGAAAAATGATAGGCATAATATCAGTCAATTACTGAATCAAATGAACAAAACCATTTCTCGTTATATTAGTGGTGTAGCTATTGATGCTGCCTTCATATTTGTTTTTGCTTTAATTGGTTATCAGATTATGGGCGTCCAGTATGCTTTCTTATTTGCTTTAGTTGCTGGGATTACTAATGTTATTCCTTATGTTGGCCCTTACTTAGGTTTGACACCAGTTGTTTTAGCTTATGTGGTCAGCGATCCTAAGAAGATGATTATTGCTATTATTTATATTATGACCTTGCAGCAAATTGATGGGAATATTGTCTACCCACGTGTTGTAGGAAGTACCATGAAAATTCATCCTTTAACAATAATGGTTCTCTTGGTGTTAGGTGGCAATATTGCTGGTTTGGTTGGTATGTTAGTTGCTGTACCAGCTTATGCTATCATTAAAGAAATTGTAAAATTCCTTGTAGGTGTTTATGATTACCACAAGAAAAATAAAATTGTGTTATAA","10.40","10.71","41037","MFKSSKLFFWTVEILLVTLILFIWRQMGSIFNPFFSVAKTFFLPFLLGGFLYYITNPIVTFLENRFKIKRIWGITLIFAVLLSLLVFSITSLIPNLINQLTDLISASQNIYVGLQDLFNEWKSNPAFKNIDIPVLLKQFNLSYVDILTNVLDSVTVSVSSIVYMITNTVMILVLTPVILFYLLKDKDGLMPMLDRTILKNDRHNISQLLNQMNKTISRYISGVAIDAAFIFVFALIGYQIMGVQYAFLFALVAGITNVIPYVGPYLGLTPVVLAYVVSDPKKMIIAIIYIMTLQQIDGNIVYPRVVGSTMKIHPLTIMVLLVLGGNIAGLVGMLVAVPAYAIIKEIVKFLVGVYDYHKKNKIVL","1608860","For other components see SMu1545 (NBD1).","permease ( possible ABC transporter permease )","Membrane, Cytoplasm","This sequence corresponds to the previously published GI:2952526, a predicted permease in GenBank. Significant hits in gapped BLAST to permease. Residues 1-364 are 93% similar to >gi|2952526 as seen in S. mutans. Residues 1-358 are 50% similar to >gi|15902821 as seen in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1194 (9e-42).","

InterPro
IPR002549
Family

Protein of unknown function UPF0118
PTHR21716	$\"[99-351]T$	UPF0118
PF01594	$\"[18-351]T$	UPF0118

","BeTs to 12 clades of COG0628COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0628 is amtK-qVCEBRHuj--ol--xNumber of proteins in this genome belonging to this COG is 3","***** IPB002549 (Domain of unknown function DUF20) with a combined E-value of 1.2e-17. IPB002549A 11-23 IPB002549B 303-340","Residues 6-99 are 88% similar to a (PROTEOME COMPLETE TRANSMEMBRANE PERMEASE) protein domain (PD132771) which is seen in O68573_STRMU.Residues 100-156 are identical to a (PERMEASE) protein domain (PD251636) which is seen in O68573_STRMU.Residues 157-347 are 93% similar to a (TRANSMEMBRANE COMPLETE PROTEOME PERMEASE INTEGRAL) protein domain (PD002159) which is seen in O68573_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:31:29 2002","Mon Oct 28 11:31:29 2002","Thu Oct 17 08:12:14 2002","Fri Apr 26 09:10:16 2002","Thu Feb 7 14:21:26 2002","Thu Feb 7 14:21:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1544 is paralogously related (blast p-value < 1e-3) to SMu1324 a predicted membrane protein; possible permease, and SMu1006, a predicted permease.","Thu Feb 7 14:22:38 2002","","No significant hits to the NCBI PDB database.","SMU.1694c","","Residues 18 to 351 (E-value = 2.4e-122) place SMu1544 in the UPF0118 family which is described as Domain of unknown function DUF20 (PF01594)","Thu Feb 7 14:21:26 2002","24380070","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)PUBMED 11029425","","Mon Oct 28 11:31:29 2002","","1","","","SMU.1694c","" "SMu1545","1610015","1610797","783","ATGGCACTCATTTCCATGAAAAATGTGACCTTAAAAAAACAGGGCAAAATCTTGCTCAACAATCTTAATTGGAAAGTCAAAAAGGGAGAAAATTGGGTTATTCTAGGTCTTAACGGTTCTGGAAAAACCACTCTTTTAAAACTTATTATGGCGGAGTATTGGTCAACACAAGGACAGGTTGAAATTCTCAATACTAGGTTTGGTCAGGGTGATATTCCCAATATGCGGACTAAAATCGGTGTCGTGGGCTCTTTTATTGCTGAGCGACTCCCTGCAAATATGTTGGCTGAAAAGATCGTGCTAACTGGTAAATACAAATCAAGCATTCTCTACAAGGAATACGACGAAACAGAACTTAATGAAGCACGCCAAATGCTTACTGTCATCGGCGGAAAACACTTGCTTGGTCGCATCTATAGCAGCCTCTCACAAGGTGAAAAACAACTCCTCCTTATTGCGCGCAGCCTTATGGAAGATCCTGAAATCATTATTTTGGATGAAGCAACCAGCGGACTGGATCTTTTTGCCCGTGAAAAATTGCTAACACAAGTTGAAAAGATTACTGAGTTACCACATGCTCCAACTATCCTTTATGTTACCCACCATGCTGAAGAAATCACTGATAAAATGAGTCATATCCTCCTCCTTCGTAGAGGTAAAATAGTGGCTCAAGGTCCTAAAAAAGATATTATTACACCTCAAGTCCTTGAAAATTTTTATGAAAGTCCCGTCAATATCATTTCCATTGATGACAAACGTTTTTTTATCAAACCGCAAGTATGA","10.00","6.21","29352","MALISMKNVTLKKQGKILLNNLNWKVKKGENWVILGLNGSGKTTLLKLIMAEYWSTQGQVEILNTRFGQGDIPNMRTKIGVVGSFIAERLPANMLAEKIVLTGKYKSSILYKEYDETELNEARQMLTVIGGKHLLGRIYSSLSQGEKQLLLIARSLMEDPEIIILDEATSGLDLFAREKLLTQVEKITELPHAPTILYVTHHAEEITDKMSHILLLRRGKIVAQGPKKDIITPQVLENFYESPVNIISIDDKRFFIKPQV","1610807","For other components see SMu1544 (MSD1).","ABC transporter, ATP-binding protein; possible molybdenum transport system","Membrane, Cytoplasm","This sequence corresponds to the previously published GI:2062756, GI:2492598, and GI:2952525, predicted ABC transporters in GenBank. Significant hits in gapped BLAST to ABC transporter. Residues 1-256 are 55% similar to >gi|15673204, >gi|13878959, and >gi|486728 as seen in L. lactis. Residues 2-258 are 42% similar to >gi|1857045 as seen in Leuconostoc mesenteroides subsp. cremoris.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2129 (4e-19).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[141-184]T$	ABC_transporter
PF00005	$\"[29-219]T$	ABC_tran
PS00211	$\"[142-156]T$	ABC_TRANSPORTER_1
PS50893	$\"[4-243]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-229]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-241]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-251]T$	PTHR19222
PTHR19222:SF31	$\"[4-251]T$	PTHR19222:SF31
SSF52540	$\"[3-234]T$	SSF52540

","BeTs to 4 clades of COG1119COG name: ABC-type molybdenum transport system, ATPase component/photorepair protein PhrAFunctional Class: PThe phylogenetic pattern of COG1119 is ----y---ebr----------Number of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.9e-25. IPB001140A 18-64 IPB001140B 139-177 IPB001140C 196-225","Residues 192-254 are identical to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD012247) which is seen in ABCX_STRMU.Residues 100-216 are 33% similar to a (YDR061 ATP-BINDING METAL MEMBRANE) protein domain (PD133621) which is seen in Q12298_YEAST.Residues 186-256 are 39% similar to a (ATP-BINDING PROTEOME COMPLETE 3'REGION) protein domain (PD406769) which is seen in YLUD_LACLA.Residues 3-69 are 40% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD278888) which is seen in O53288_MYCTU.Residues 67-139 are 28% similar to a (PROTEOME COMPLETE YLMA) protein domain (PD028038) which is seen in P97112_LEUMC.Residues 63-141 are identical to a (ATP-BINDING ABC TRANSPORT TRANSPORTER) protein domain (PD028075) which is seen in ABCX_STRMU.Residues 19-62 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in ABCX_STRMU.Residues 142-181 are identical to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in ABCX_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:27:32 2002","Thu Feb 7 14:29:26 2002","Thu Oct 17 08:11:08 2002","Fri Apr 26 08:56:07 2002","Thu Feb 7 14:29:26 2002","Tue Oct 29 14:27:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1545 is paralogously related (blast p-value < 1e-3) to ABC transporters: SMu1950, SMu0884, SMu0258, SMu1518, SMu1210, SMu0390, SMu0335, SMu1003, SMu0836, SMu0907, SMu1949, SMu1410, SMu0825, SMu1920, SMu0944, SMu0517, SMu1710, SMu0849, SMu0476, SMu1762, SMu0916, SMu1757, SMu0418, SMu0164, SMu1093, SMu0986, SMu1064, SMu0971, SMu1751, SMu0824, SMu0596, SMu0837, SMu0475, SMu0235, SMu1380, SMu1023, SMu0987, SMu0218, SMu0786, SMu1079, SMu1246, SMu1231, SMu1068, SMu0976, SMu1065, SMu0216, SMu1517, SMu1001, SMu1811, SMu0594, SMu1649, SMu0374, SMu1724, SMu0666, SMu0731, SMu1959, SMu1316, SMu0729, SMu1428, SMu1306, SMu0224, SMu0024, SMu1288, SMu0950, SMu0805, SMu1037, SMu0823, SMu0234, SMu1050, SMu1036, SMu0752, and SMu1202, all ATP-binding proteins.","Wed Feb 27 10:33:59 2002","Thu Feb 7 14:29:26 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 68 1e-012pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 62 9e-011","SMU.1695","","Residues 29 to 219 (E-value = 4.1e-47) place SMu1545 in the ABC_tran family which is described as ABC transporter (PF00005)","Thu Feb 7 14:29:26 2002","24380071","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)","","Tue Oct 29 14:27:32 2002","","1","","","SMU.1695","" "SMu1546","1611476","1610931","546","ATGATCAAACGTCCCATTGAACTCTCTCATGATTTTTTGTCCCAAGTTTTGGATAAAAACAGTATAGCCATTGATGCGACTATGGGCAACGGAAATGATACCGTTTTTTTGTCCCATCTTGCTAAGAAAGTCTACGCTTTTGATGTACAGGAACAGGCCTTAATCAAGACGAGAGAAAAACTGGAACAATTAAATATTAAAAATGTCCAACTCATTTTAGATGGACATCAAACTATTAATAAATATGTGACTGAACCTATCCGTGCAGCTATTTTTAATTTAGGTTATCTGCCTTCGGCAGACAAGTCAGTCATTACTCAGCCTGCTACAACCCTGACAGCTATTAAAAAGATTTTAGAGAGATTAGAAATTGGCGGTCGTTTGGCAATTATGGTATATTATGGTCATGAGGGTGGCGATAAGGAAAAAGATGCGGTTCTGAACTTTGTTAAAGAGCTAGATCAACAGCATTTTACAGTCATGCTTTATCAACCCTTAAATCAAATAAATACCCCACCCTTTTTGGTGATGATAGAGAAATTATAA","7.10","0.20","20462","MIKRPIELSHDFLSQVLDKNSIAIDATMGNGNDTVFLSHLAKKVYAFDVQEQALIKTREKLEQLNIKNVQLILDGHQTINKYVTEPIRAAIFNLGYLPSADKSVITQPATTLTAIKKILERLEIGGRLAIMVYYGHEGGDKEKDAVLNFVKELDQQHFTVMLYQPLNQINTPPFLVMIEKL","1610947","This sequence corresponds to the previously published GI:2952524, a predicted YtqB in GenBank. ","possible rRNA methylase, SAM-dependent methyltransferase superfamily","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-181 are 69% similar to >gi15674524 as seen in S. pyogenes. Residues 2-181 are 61% similar to >gi15902615 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1400 (5e-72).","

InterPro
IPR010719
Family

Putative rRNA methylase
PF06962	$\"[43-180]T$	rRNA_methylase

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[17-130]T$	G3DSA:3.40.50.150
SSF53335	$\"[17-180]T$	SSF53335

","BeTs to 4 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 44-180 are 52% similar to a (PROTEOME COMPLETE METHYLTRANSFERASE RRNA) protein domain (PD105958) which is seen in Q9CDF6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:55:44 2002","Tue Aug 1 10:32:00 2006","Tue Aug 1 10:32:00 2006","Tue Oct 8 17:55:44 2002","","Thu Feb 7 14:34:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1546 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:55:44 2002","","No significant hits to the NCBI PDB database.","SMU.1697c","","Residues 43 to 180 (E-value = 4.3e-94) place SMu1546 in the rRNA_methylase family which is described as Putative rRNA methylase (PF06962)","Thu Feb 7 14:34:38 2002","24380072","","Boyd,D.A., Cvitkovitch,D.G., Bleiweis,A.S., Kiriukhin,M.Y., Debabov,D.V., Neuhaus,F.C. and Hamilton,I.R.Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid SensitivityJ. Bacteriol. 182 (21), 6055-6065 (2000)","","Tue Aug 1 10:32:00 2006","","1","","","SMU.1697c","699" "SMu1547","1612405","1611473","933","ATGAATAAACGTTATAATACATTAAATGACTATTACCGTCGTATTTTTGGCGAAAAGACTTTTAAGGTTCCCATTGATGCTGGCTTTGACTGCCCAAACCGTGATGGAACTGTGGCTCATGGTGGCTGTACTTTTTGTACGGTTTCAGGTTCTGGTGATGCTATTGTGGCACCAGAAGCTCCTATTCGGGACCAATTTTACAAGGAAGTTGATTTCATGCATCGCAAATGGCCGGATGTCAAGAAGTACCTCGTTTATTTTCAAAATTTTACCAATACCCATGACAAGGTTGAGGTCATTCGGGAGCGCTATGAGCAGGCTATCAATGAACCTGGTGTTATTGGTATCAATATTGGAACAAGACCGGACTGTTTGCCTGATGTGACTATCCTTTACCTAGCGGAGCTATCCCAACGTTTGCATGTGACCTTGGAGTTAGGCTTACAGACAACCTATGAAAAAACGTCCAAGTTAATTAATCGTGCTCATTCTTATCAACTTTATGTAGAAACTGTTAAACGCGTAAGAGATTTGGCGCCAAAAGTTGAAATTGTTTCCCATCTCATCAATGGTTTACCAGGTGAAAGCCATGAGATGATGCTGGAAAATGTTCGCCGTTGTGTGACAGATAATGACATTGATGGCATTAAACTCCATCTTCTACATCTCATGACCAATACGCGTATGCAACGTGATTATCATGAGGGACGCTTACATCTGCTGAGTATGGAAGAATATGTCAACATTATCTGTGACCAATTAGAAATTATTCCTAAAAACATTGTCATTCATCGTCTGACAGGTGATGCACCGCGTGATATGTTGATTGGACCGATGTGGAGCCTTAACAAGTGGGAAGTTTTAAATAGCATTGATAGGGAAATGGAAAGGCGTAATGCTTATCAAGGCTGTAAGCTGGAGGTGAATATATGA","6.80","-1.42","35980","MNKRYNTLNDYYRRIFGEKTFKVPIDAGFDCPNRDGTVAHGGCTFCTVSGSGDAIVAPEAPIRDQFYKEVDFMHRKWPDVKKYLVYFQNFTNTHDKVEVIRERYEQAINEPGVIGINIGTRPDCLPDVTILYLAELSQRLHVTLELGLQTTYEKTSKLINRAHSYQLYVETVKRVRDLAPKVEIVSHLINGLPGESHEMMLENVRRCVTDNDIDGIKLHLLHLMTNTRMQRDYHEGRLHLLSMEEYVNIICDQLEIIPKNIVIHRLTGDAPRDMLIGPMWSLNKWEVLNSIDREMERRNAYQGCKLEVNI","1611489","","conserved hypothetical protein, radical SAM superfamily","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-307 are 82% similar to >gi15674523 as seen in S. pyogenes. Residues 1-305 are 72% similar to >gi15674248 as seen in L. lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1401 (1e-162).","

InterPro
IPR005911
Family

Conserved hypothetical protein 1212
TIGR01212	$\"[4-308]T$	CHP1212

InterPro
IPR006638
Domain

Elongator protein 3/MiaB/NifB
SM00729	$\"[21-252]T$	Elp3

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[25-207]T$	Radical_SAM

noIPR
unintegrated

unintegrated
PTHR11135	$\"[79-277]T$	PTHR11135
SSF102114	$\"[10-297]T$	SSF102114

","BeTs to 5 clades of COG1242COG name: Uncharacterized FeS oxidoreductasesFunctional Class: RThe phylogenetic pattern of COG1242 is -m---qv-eb-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 7-116 are 76% similar to a (PROTEOME COMPLETE BH3284 PLASMID) protein domain (PD016462) which is seen in Q9CDF5_LACLA.Residues 11-121 are 31% similar to a (MJ0486) protein domain (PD094309) which is seen in Y486_METJA.Residues 182-229 are 50% similar to a (BIOTIN SYNTHASE SYNTHETASE IRON-SULFUR) protein domain (PD003026) which is seen in O35008_BACSU.Residues 118-195 are 45% similar to a (PROTEOME COMPLETE OXIDASE III COPROPORPHYRINOGEN) protein domain (PD000690) which is seen in Q9KPJ6_VIBCH.Residues 122-206 are 63% similar to a (COMPLETE OXIDASE PROTEOME III) protein domain (PD342340) which is seen in Q9CDF5_LACLA.Residues 219-303 are 54% similar to a (PROTEOME BH3284 COMPLETE PLASMID) protein domain (PD414073) which is seen in Q9K7S5_BACHD.Residues 233-305 are 79% similar to a (PROTEOME COMPLETE MJ0486 YXFC) protein domain (PD021981) which is seen in Q9CDF5_LACLA.Residues 229-300 are 33% similar to a (PROTEOME COMPLETE VC2371 ARCB-GLTB) protein domain (PD094257) which is seen in Q9KPJ6_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:54:35 2002","Thu Sep 14 13:45:09 2006","Thu Sep 14 13:45:09 2006","Tue Oct 8 17:54:35 2002","","Thu Feb 7 14:39:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1547 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:54:35 2002","","No significant hits to the NCBI PDB database.","SMU.1699c","","Residues 25 to 207 (E-value = 5e-12) place SMu1547 in the Radical_SAM family which is described as Radical SAM superfamily (PF04055)","Thu Feb 7 14:39:40 2002","24380073","","","","","","1","","","SMU.1699c","419" "SMu1548","1613205","1612510","696","ATGAATTTTATTTTTTCGAATCCTCTTTTTGGTCTTTGGCTGTCTATATTTGCCTATTTGATAGGTATTTTGATTTTTAGGCGTTTTCCACATCCACTAACAACCCCACTTTTACTAGCAACGATTATTGTTATTATTTTTTTAAAAGTAACGCATATTTCTTATCAAGACTATTATAAGGGAGGAGCGTATTTAAATACCCTTATTGTACCTTCGACAGTTGCTTTGGGAATTCCTTTGTATCAGACTTTCCATTTAATGAGGCATCATGCCAGAAGTATTATTTTGGGTAGCTTTTTAGCAGCAGTTGTCAATACGAGTTTTACTGCCTTTGTGGCAAAAGTTTTTGGCATGGATTTCTTTTTAGCCATTTCCTTGTTTCCTAAATCTGTTACAACCGCAATGGCAGTCGGAATTGTTGATAAGATGCAGGGAATTACGACCGTAACACTGGTTGTTGTTGTAGCAACTGGTATTTTAACTAGTGTTTTGGGGCCAACTCTTTTAAAATTATTGAAAATCGAAGATCCTGTGGCCATTGGTTTGGCTCTTGGTGGAACTGGACATGCTGTTGGTACTGGAACGGCTCTTAAATACGGTAGAATATCGGGAGCTATGGCTGGTCTAGCTATTGGCATTACGGGTTTGATGTATGTCTTTGTATCGCCCATTGTGGCAGCCATTATTTTAAAATGA","10.80","10.42","24658","MNFIFSNPLFGLWLSIFAYLIGILIFRRFPHPLTTPLLLATIIVIIFLKVTHISYQDYYKGGAYLNTLIVPSTVALGIPLYQTFHLMRHHARSIILGSFLAAVVNTSFTAFVAKVFGMDFFLAISLFPKSVTTAMAVGIVDKMQGITTVTLVVVVATGILTSVLGPTLLKLLKIEDPVAIGLALGGTGHAVGTGTALKYGRISGAMAGLAIGITGLMYVFVSPIVAAIILK","1612526","","LrgB-like protein; possible murein hydrolase regulator","Membrane, Cytoplasm, Extracellular","Significant hits in gapped BLAST to conserved hypothetical protein. Residues 1-230 are 44% similar to >gi15672743 as seen in L. lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1148 (1e-64).","

InterPro
IPR007300
Family

LrgB-like protein
PF04172	$\"[15-229]T$	LrgB

","BeTs to 3 clades of COG1346COG name: Predicted membrane protein, YohK familyFunctional Class: SThe phylogenetic pattern of COG1346 is ---k----eB-h---------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 14-226 are 43% similar to a (PROTEOME COMPLETE TRANSMEMBRANE BH3268) protein domain (PD009617) which is seen in Q9CHH0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 14:46:13 2002","Wed Aug 30 15:25:03 2006","Wed Aug 30 15:25:03 2006","Tue Oct 8 17:54:09 2002","","Thu Feb 7 14:41:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1548 is paralogously related (blast p-value < 1e-3) to SMu0523, a conserved hypothetical protein; possible membrane protein.","Thu Feb 7 14:46:13 2002","","No significant hits to the NCBI PDB database.","SMU.1700c","","Residues 15 to 229 (E-value = 8.8e-104) place SMu1548 in the LrgB family which is described as LrgB-like family (PF04172)","Thu Feb 7 14:41:46 2002","24380074","","","","","","1","","","SMU.1700c","569" "SMu1549","1613543","1613202","342","ATGATTATTCTCCTCTTTTCTTTAGTGGGCGAATTTGCTTCCAATAGTTTACATTTACCTGTTCCAGGAAGCATTATTGGACTTTTTTGTCTCTTTTTAGCTTTGCAGTTTAATTGGATCCGTTTGCGTCATATCAATGCAGTTGGTCAATTTTTACTAGCTAATATGACTATTTTGTTTTTGCCAGCAGCAGTGGGGATTATGGATAAGTTTAATGTGATTGCCCCTTATCTGCTACCAATTTGTCTGATTTTATTATTTGCTGTCATTCTCAATATTGCAGTGATTGCTTTAGTTGTCCAATTTATCAAGAGACATTATGAAGGAGACTTTCCAGAATGA","7.40","0.61","12607","MIILLFSLVGEFASNSLHLPVPGSIIGLFCLFLALQFNWIRLRHINAVGQFLLANMTILFLPAAVGIMDKFNVIAPYLLPICLILLFAVILNIAVIALVVQFIKRHYEGDFPE","1613218","","conserved hypothetical protein","Membrane, Cytoplasm, Extracellular","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-111 are 44% similar to >gi|15672744 as seen in L. lactis. Residues 2-69 are 41% similar to >gi|15925531 as seen in Staphylococcus aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1147 (1e-29).","

InterPro
IPR005538
Family

LrgA
PD009239	$\"[31-105]T$	LrgA
PF03788	$\"[1-105]T$	LrgA

","BeTs to 3 clades of COG1380COG name: Predicted membrane protein, YohJ familyFunctional Class: SThe phylogenetic pattern of COG1380 is ---k----eB-h---------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 1-77 are 55% similar to a (PROTEOME COMPLETE TRANSMEMBRANE BH3269) protein domain (PD009239) which is seen in Q9CHG9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 14:45:14 2002","Thu Feb 7 14:44:13 2002","Thu Feb 7 14:45:14 2002","Tue Oct 8 17:53:16 2002","","Thu Feb 7 14:44:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1549 is paralogously related (blast p-value < 1e-3) to SMu0524, a conserved hypothetical protein; possible membrane protein.","Thu Feb 7 14:45:14 2002","","No significant hits to the NCBI PDB database.","SMU.1701c","","Residues 1 to 105 (E-value = 2.5e-31) place SMu1549 in the LrgA family which is described as LrgA family (PF03788)","Thu Feb 7 14:44:13 2002","24380075","","","","","","1","","","SMU.1701c","935" "SMu1550","1614380","1613730","651","ATGAAAATTAAACAAACTTATCTTTTAAGAGCTTCCTTTGCTTTTTTACTTTTAATGTTTCTAGGATACTTGGTCAAATTTTACCCTGATAATTTGACTGGTATTGATACCAATATTCAGAGCGCTATGCGAGGGGATTTTCCTTCAGTAGAAACTTGTTTTTTTACTACTATTACTAATTTTGGAAATGAATTATTTTTATTCATCTTTTGTATTTTTTTGTTTTTTCTATTTTATATCAAAAATTGGAAAGCTGAAGCTGGATTTATTTTGGCGAATTTCGCAACTGTAGGTTTGCTGTCAACAGCTTTAAAGTACCTGTATCAAAGACCACGTCCTAAGATTAAGTGGCTGATTCAGACAACGGGCCCTTCTTTTCCTAGCTGGCATGCCGCTTCAACCTTACTGATAGCGGCAGCCATAGTTGTGATTATTCAGCAACGTATGAAAAGCAGCGTTTTAAAACTGCTCTTACAAATACTTCTTATTGTAATAGCTATTTTGGTAGGCATTTCTAGAATTTATATCGGTGTCCACCATCCAACGGATGTTTTAGGAGGCTGGCTGTTGGCCTTAGGTTTAAGTCAAATGATTTATCCTTATTATGATGAGTGGCGTTTTAAATGGCGCTTTTCAGGCAAGCAGAAGTAA","10.70","12.61","24861","MKIKQTYLLRASFAFLLLMFLGYLVKFYPDNLTGIDTNIQSAMRGDFPSVETCFFTTITNFGNELFLFIFCIFLFFLFYIKNWKAEAGFILANFATVGLLSTALKYLYQRPRPKIKWLIQTTGPSFPSWHAASTLLIAAAIVVIIQQRMKSSVLKLLLQILLIVIAILVGISRIYIGVHHPTDVLGGWLLALGLSQMIYPYYDEWRFKWRFSGKQK","1613746","","uncharacterized phosphatase; possible PAP2 family protein","Membrane, Cytoplasm, Extracellular","Significant hits in gapped BLAST to PAP2 family protein and conserved hypothetical proteins. Residues 1-216 are 39% similar to >gi|15902478 and >gi|15900403 as seen in S. pneumoniae. Residues 1-215 are 40% similar to >gi|15674522 as seen in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1402 (8e-28).","

InterPro
IPR000326
Family

Phosphoesterase, PA-phosphatase related
PF01569	$\"[86-207]T$	PAP2
SM00014	$\"[87-199]T$	acidPPc

InterPro
IPR008934
Family

Acid phosphatase/vanadium-dependent haloperoxidase
SSF48317	$\"[10-216]T$	AcPase_VanPerase

noIPR
unintegrated

unintegrated
G3DSA:1.20.144.10	$\"[64-197]T$	G3DSA:1.20.144.10
PTHR14969	$\"[75-192]T$	PTHR14969
PTHR14969:SF3	$\"[75-192]T$	PTHR14969:SF3

","BeTs to 10 clades of COG0671COG name: Predicted phosphatasesFunctional Class: RThe phylogenetic pattern of COG0671 is -mtkYq-cEBrhUJ---l--xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 99-189 are 29% similar to a (PROTEOME COMPLETE MEMBRANE INTEGRAL) protein domain (PD356988) which is seen in Q06074_BACME.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 14:49:53 2002","Wed Feb 27 10:38:10 2002","Mon Oct 21 15:43:11 2002","Mon Oct 21 15:43:11 2002","","Thu Feb 7 14:49:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1550 is paralogously related (blast p-value < 1e-3) to SMu0812, a conserved hypothetical protein.","Thu Feb 7 14:49:53 2002","","No significant hits to the NCBI PDB database.","SMU.1702c","","Residues 71 to 207 (E-value = 2e-29) place SMu1550 in the PAP2 family which is described as PAP2 superfamily (PF01569)","Thu Feb 7 14:49:12 2002","24380076","","","","","","1","","","SMU.1702c","946" "SMu1551","1614996","1614370","627","ATGTTACACTCTTTAGGCCTTCTTTCGATTTGTAAAAATTGGAGGAATTTTTTTATGAAAAAAACACAGACAATGACTATCATTGCAATTCTATCAGCGCTCTCTTTTGTGCTTATGATCCCTAACTTTCCAATTATTCCAGGCGTGGATTTTTTGAAACTTGACTTTAGTATTCTTCCTATTTTATTGGGTTTAATCCTACTTGATTTAAAAAGTGCCTATGTCATCCTTTTTTTGAGAAGTCTACTTAAACTTTTGCTGGATAATGGTGGACCTGGTAGTATGGTTGGTTTGCCAATGAACATGGTGGCTTTTGGAATTTTTATTCTTTCTTTTGCGCTTATTTGGAAAGTTAGAGATAGTAAGGTGAAATATGTCTTGGCTAGTATTGTTGGGACATTAGCAATGACAGTGACCATGGTCTTTCTCAACTATGTTTATGCCATTCCCCTTTATGCTAAGTTTGCTAATTTTGATATTTCAAAATTCATCGGTGTTGGGAAGTATTTAATGAGCATGGTCATCCCTTTTAACTTACTTGAAGGGGTGATCTTTGCGGTCAGTTTTGCTGTGGTTTATGCAGCCACTCAACCTATTTTAAAGAATTATATAAGTAATGAAAATTAA","10.40","8.17","23151","MLHSLGLLSICKNWRNFFMKKTQTMTIIAILSALSFVLMIPNFPIIPGVDFLKLDFSILPILLGLILLDLKSAYVILFLRSLLKLLLDNGGPGSMVGLPMNMVAFGIFILSFALIWKVRDSKVKYVLASIVGTLAMTVTMVFLNYVYAIPLYAKFANFDISKFIGVGKYLMSMVIPFNLLEGVIFAVSFAVVYAATQPILKNYISNEN","1614386","","conserved hypothetical protein","Membrane, Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 19-204 are 48% similar to >gi|15674521 as seen in S. pyogenes. Residues 19-203 are 45% similar to >gi|15674521 as seen in S. pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1403 (3e-50).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-39]?$	signal-peptide
tmhmm	$\"[26-46]?$ $\"[56-76]?$ $\"[95-115]?$ $\"[125-147]?$ $\"[175-195]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 19-173 are 32% similar to a (PROTEOME COMPLETE SERA-FER YNAE) protein domain (PD104992) which is seen in Q9CG36_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:52:18 2002","Thu Feb 7 14:51:59 2002","Tue Oct 8 17:52:18 2002","Thu Feb 7 14:51:59 2002","","Thu Feb 7 14:51:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1551 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:52:18 2002","","No significant hits to the NCBI PDB database.","SMU.1703c","","No significant hits to the Pfam 11.0 database","Thu Feb 7 14:51:59 2002","24380077","","","","","","1","","","SMU.1703c","830" "SMu1552","1615455","1615781","327","ATGTATTATCCTGTTTCAGCCCTGCTAATAGAATACTTAATTTTGGCTATCGTCAGTAAACATGACTCCTACGGTTACGATATCAGTCAAACTATTAAACTAATTGCCAGTATCAAAGAATCCACTTTATATCCTATCTTAAAAAAACTTGAAAAAGCAGGATATTTAAGTACTTACACTCAAGAACATCAAGGTCGACGACGAAAGTATTATCATTTAACCGATTCGGGAGAAAAACATCTCGTTTATCTGACTAAGGAATGGTCAGTTTATAAAATGACCATTGATGGCATTGTAGAAGGGAGAATTCGCCATGACAAGAACTGA","10.00","5.19","12673","MYYPVSALLIEYLILAIVSKHDSYGYDISQTIKLIASIKESTLYPILKKLEKAGYLSTYTQEHQGRRRKYYHLTDSGEKHLVYLTKEWSVYKMTIDGIVEGRIRHDKN","1615791","","conserved hypothetical protein","Cytoplasm, Membrane","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-108 are 73% similar to >gi|15675909 as seen in S. pyogenes. Residues 1-108 are 64% similar to >gi|15902133 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0264 (1e-09).","

InterPro
IPR005149
Family

Transcriptional regulator PadR-like
PF03551	$\"[9-84]T$	PadR

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[8-91]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[4-100]T$	SSF46785

InterPro
IPR012963
Family

Protein of unknown function DUF1700
PIRSF032110	$\"[1-197]T$	UPD032110_mp
PF08006	$\"[1-59]T$	DUF1700

noIPR
unintegrated

unintegrated
PS51257	$\"[1-17]T$	PROKAR_LIPOPROTEIN

InterPro
IPR001537
Domain

tRNA/rRNA methyltransferase, SpoU
PD001243	$\"[19-164]T$	SpoU_mtfrase
PF00588	$\"[17-159]T$	SpoU_methylase

noIPR
unintegrated

unintegrated
G3DSA:3.40.1280.10	$\"[17-177]T$	G3DSA:3.40.1280.10
PTHR12029	$\"[4-172]T$	PTHR12029
PTHR12029:SF11	$\"[4-172]T$	PTHR12029:SF11
SSF75217	$\"[17-173]T$	SSF75217

","BeTs to 6 clades of COG0219COG name: Predicted rRNA methylase (SpoU class)Functional Class: JThe phylogenetic pattern of COG0219 is -------cebrh--gp--in-Number of proteins in this genome belonging to this COG is 1","***** IPB001537 (tRNA/rRNA methyltransferase (SpoU)) with a combined E-value of 8.9e-22. IPB001537A 20-44 IPB001537B 114-122 IPB001537C 147-160","Residues 60-171 are 64% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE METHYLASE RRNA) protein domain (PD331903) which is seen in Q9CGE7_LACLA.Residues 19-171 are 36% similar to a (METHYLASES SPOU METHYLTRANSFERASE OF) protein domain (PD091729) which is seen in O04633_ARATH.Residues 20-58 are 84% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE METHYLASE RRNA) protein domain (PD339659) which is seen in YGL3_BACST.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 15:06:42 2002","Thu Oct 24 13:27:58 2002","Fri Aug 18 13:25:10 2006","Thu Apr 11 09:10:34 2002","Thu Feb 7 15:06:05 2002","Thu Feb 7 15:06:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1555 is paralogously related (blast p-value < 1e-3) to SMu0147, a predicted tRNA/rRNA methyltransferase.","Thu Feb 7 15:06:42 2002","","No significant hits to the NCBI PDB database.","SMU.1707c","","Residues 17 to 159 (E-value = 3.1e-41) place SMu1555 in the SpoU_methylase family which is described as SpoU rRNA Methylase family (PF00588)","Thu Feb 7 15:06:05 2002","24380081","","","","","","1","","","SMU.1707c","709" "SMu1556","1618381","1619736","1356","ATGAAAATTATTGTCGTTGGTGGCGGCAAGGTCGGTAAGGCTCTCTGTCGCTCACTGGTGGAAGAAGAACATGATGTTATTTTGATTGAAGAAAATGAATCCGTCCTCAATCATGTCACCAAACGTCTTGATATCATGGGAATAGTCGGTAATGGTGCTAACTTTAGAATTTTAGAACAGGCTGATGTGCAACATTGTGATATTTTTATTGCTATTACTGATAAAGATGAAGTGAATATGGTAGCTGCTGTTCTAGCTAAAAGAATGGGGGCTAAAGAAACCATTGTCCGTGTTCGTAATCCTGAATATTCCAACACCTACTTTAAAGACAAGAACTTTCTTGGTTTTTCTTTAGTAGTTAATCCTGAACTTTTGACAGCACGTTATATCGCCAATATGGTTGATTTCCCTAATGCACGATCAGTTGAACATTTTGTCAATGGTCGTGTCATGTTAATGGAATTTAAAATTGTTGACGGTAACAACCTCTGTCAAATGTCCTTGAATCAATTCCGTAAAAGATTCAATAATATTGTCATCTGCGCTATTGAGCGTGGAAATGAGCTCATTATTCCTGATGGTGATGCTGTCATTCAGTCAGGGGATAAAATTTTCGTAACAGGCAAGCGTATGGAAATGATTCATTTCCATAATTTTGTTAAAAATAAAGTTATCAAACATCTAATGATTATTGGTGCAGGAAGAATTTCCTACTATTTGCTTAATATTCTCAAGACTACCAATCGTCATCTTCAAGTCAAAGTCATTGAACTTAATCCTAAAAAGGCTGAACTATTTAGTCAAGAATTCCCCCATATCCATGTCGTTCAAGGAGATGGAACTGCTAAAGATATCCTCTTAGAAGAGAGTGCTGCAAACTACGATGCTATTGCGACCTTAACTGGTGTTGATGAAGAAAATATTATTGCTTCCATGTTTTTAGAAACATTAGGTGTGCAAAAAAACATTACTAAAGTCAATCGTACTAGTATTTTAGAAATTATTAACCCTGAACAGTTTTCAAGCATTATCACTCCTAAGAGCATTGCGGTTGATTCCATGATGCATTTTATTCGCGGTCGTGTTAATGCTCAAGATTCTAATCTAGATGCTATGCACCATGTAGCAAATGGTCGTATTGAAACTTTGCAATTTGAAATTCGCCAAACCAACAAAATGGCTGGTAAAACATTGTCTGAACTTCATTTTAAGACCAATGTTTTAATTGCAGCCATCATTCGCAATGGTAAAACAATTTTCCCTACTGGTGATGATATTCTTGAAGTAGGTGACAAGATTGTTGTCATTACACTTCTTACAAACATCACTCATATTTATGATTTATTAAAGAGGTAA","7.40","2.45","50705","MKIIVVGGGKVGKALCRSLVEEEHDVILIEENESVLNHVTKRLDIMGIVGNGANFRILEQADVQHCDIFIAITDKDEVNMVAAVLAKRMGAKETIVRVRNPEYSNTYFKDKNFLGFSLVVNPELLTARYIANMVDFPNARSVEHFVNGRVMLMEFKIVDGNNLCQMSLNQFRKRFNNIVICAIERGNELIIPDGDAVIQSGDKIFVTGKRMEMIHFHNFVKNKVIKHLMIIGAGRISYYLLNILKTTNRHLQVKVIELNPKKAELFSQEFPHIHVVQGDGTAKDILLEESAANYDAIATLTGVDEENIIASMFLETLGVQKNITKVNRTSILEIINPEQFSSIITPKSIAVDSMMHFIRGRVNAQDSNLDAMHHVANGRIETLQFEIRQTNKMAGKTLSELHFKTNVLIAAIIRNGKTIFPTGDDILEVGDKIVVITLLTNITHIYDLLKR","1619746","For other 'trk' genes see SMu1557 (trkH); SMu1419 (trkB) and SMu1420 (trkA).","potassium uptake system protein","Cytoplasm","Significant hits in gapped BLAST to potassium uptake proteins. Residues 14-451 are 68% similar to >gi15900395 and >gi15902471 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1590 (0.0).","

InterPro
IPR003148
Domain

TrkA-N
PF02254	$\"[3-122]T$ $\"[228-346]T$	TrkA_N
PS51201	$\"[2-128]T$ $\"[227-350]T$	RCK_N

InterPro
IPR006036
Family

TrkA potassium uptake protein
PR00335	$\"[2-16]T$ $\"[19-33]T$ $\"[49-59]T$ $\"[60-70]T$ $\"[73-87]T$	KUPTAKETRKA

InterPro
IPR006037
Domain

TrkA-C
PF02080	$\"[152-221]T$ $\"[382-450]T$	TrkA_C
PS51202	$\"[140-222]T$ $\"[370-451]T$	RCK_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-140]T$ $\"[222-359]T$	G3DSA:3.40.50.720
SSF51735	$\"[1-222]T$ $\"[226-451]T$	SSF51735

","BeTs to 10 clades of COG0569COG name: Potassium uptake system NAD-binding component TrkAFunctional Class: PThe phylogenetic pattern of COG0569 is AmtK-Q-CEBRh--gpoL---Number of proteins in this genome belonging to this COG is 3","***** PR00335 (TrkA potassium uptake protein signature) with a combined E-value of 2e-06. PR00335A 2-16 PR00335B 19-33 PR00335E 73-87","Residues 228-349 are 30% similar to a (COMPLETE PROTEOME POTASSIUM TRANSPORT) protein domain (PD001173) which is seen in Q9JQZ0_NEIMB.Residues 378-437 are 33% similar to a (POTASSIUM PROTEOME COMPLETE SYSTEM) protein domain (PD328660) which is seen in TRKA_ARCFU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 15 09:26:54 2006","Tue Aug 15 09:26:54 2006","Tue Aug 15 09:26:54 2006","Wed Apr 10 15:57:48 2002","Thu Feb 7 15:10:15 2002","Thu Feb 7 15:10:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1556 is paralogously related (blast p-value < 1e-3) to predicted potassium uptake proteins: SMu1419, and SMu1420.","Thu Feb 7 15:11:16 2002","","No significant hits to the NCBI PDB database.","SMU.1708","","Residues 2 to 122 (E-value = 4.3e-20) place SMu1556 in the TrkA_N family which is described as TrkA-N domain (PF02254)Residues 152 to 221 (E-value = 5.2e-13) place SMu1556 in the TrkA_C family which is described as TrkA-C domain (PF02080)Residues 227 to 346 (E-value = 2.8e-05) place SMu1556 in the TrkA_N family which is described as TrkA-N domain (PF02254)Residues 382 to 450 (E-value = 2.3e-15) place SMu1556 in the TrkA_C family which is described as TrkA-C domain (PF02080)","Tue Aug 15 09:26:54 2006","24380082","","","","","","1","","","SMU.1708","162" "SMu1557","1619743","1621182","1440","ATGAATAAAAGTATGGTACGCTTTCTCTTATCAAAATTATTGTTAATTGAAGCTGCACTTCTTCTTGTCCCCTTGATTGTTGCTTTCATTTATCAAGAAAGTTTTACAATCATCTTTAGCATTTTGGCCACTATGGCTATTTTAATCTTGCTTGGCAGTATTGGCATCATATTTAAACCTAAAAATTATCACATCTATACCAAAGAAGGCTTACTTATTGTAGCTCTTTGCTGGGTACTTTGGTCCTTTTTTGGAGCTCTTCCTTTTATCTTTACTGGTCAAATACCTAATATTATTGATGCTTTTTTTGAAGTTAGTTCAGGCTTCACAACAACGGGTGCCACTATTTTACCAGATGTTTCTGTTTTATCACATTCACTGCTTTTTTGGCGGAGTTTTACCCACTTAATCGGTGGGATGGGAGTACTTGTTTTTGCTCTTGCCATTATGGAAAACAGTAAAAACAGCCACTTAGAAGTTATGCGCGCAGAAGTACCTGGTCCTGTTTTTGGTAAAGTGGTCTCAAAGCTCAAAAACACTGCTCAGATCCTCTATATTATTTACCTCATTATGTTTGCTGTTTTCGCTATTATACTGTGGGGTGTTGGTATGCCTCTATATGATAGCCTCGTAACAGCAATGGGTACAGCTGGTACTGGTGGATTTACAGTTTTTAATGATGGGATTGCTCATTATCACAGTTCGCTCATTACAAATCTGGTTTCCATCGGAATGTTGCTCTTTGGAGTTAATTTTAATCTCTACTATCTTCTCTTGATTCGTAAATTTAAAACTTTCTTTGGTGATGAAGAACTGCGTACTTATATTGGTATTGCTCTGCTAGCAACCCTATTAATTTGGTTAAACGTCGGTGGACAGTTTGCAACAGCAAAAGAGGGCTTGGAAATTTCTTTCTTTCAAGTCTCCACTACCATGACTACAACTGGTTTTGGTATTACTAATCTCACAACTTGGCCGCTCTTTTCTCAGTTTATCTTGCTTCTACTGATGTTTCTTGGTGGTTCTGCTGGATCAACAGCAGGTGGATTCAAGGTTATGCGGGTATTAATTTTATCAAAAATCGCTAAAAATCAAGTTCTTTCCAGTCTCTATCCTAACCGTGTGATATCACTGCATATCAATCAGCAATCACTGGATAAAAGAACACAACACAGTGTGTTGAAATATTTAGCTATCTATCTTCTGATTTTTATTAGTCTGGTTTTAATTTTAACACTTGATAATAACAACCTTATGATTGTAACCAGCGCTGCTGCCAGTGCTTTTAACAATATTGGACCTATACTTGGTACTGATAAAACCTTTGCTATCTTTAGCCCATTTTCAAAATTAGTTCTATCATTTGCTATGATTGCGGGACGTTTAGAAATTTACCCCATGTTGTTGCTATTTATTCCAAAAACTTGGTCTAAAACTTAA","10.30","11.87","52877","MNKSMVRFLLSKLLLIEAALLLVPLIVAFIYQESFTIIFSILATMAILILLGSIGIIFKPKNYHIYTKEGLLIVALCWVLWSFFGALPFIFTGQIPNIIDAFFEVSSGFTTTGATILPDVSVLSHSLLFWRSFTHLIGGMGVLVFALAIMENSKNSHLEVMRAEVPGPVFGKVVSKLKNTAQILYIIYLIMFAVFAIILWGVGMPLYDSLVTAMGTAGTGGFTVFNDGIAHYHSSLITNLVSIGMLLFGVNFNLYYLLLIRKFKTFFGDEELRTYIGIALLATLLIWLNVGGQFATAKEGLEISFFQVSTTMTTTGFGITNLTTWPLFSQFILLLLMFLGGSAGSTAGGFKVMRVLILSKIAKNQVLSSLYPNRVISLHINQQSLDKRTQHSVLKYLAIYLLIFISLVLILTLDNNNLMIVTSAAASAFNNIGPILGTDKTFAIFSPFSKLVLSFAMIAGRLEIYPMLLLFIPKTWSKT","1621192","For other 'trk' genes see SMu1556 (trkA); SMu1419 (trkB) and SMu1420 (trkA).","potassium uptake protein TrkH","Membrane, Cytoplasm","Significant hits in gapped BLAST to potassium uptake protein, Trk family. Residues 1-478 are 60% similar to >gi15902470 and >gi15900394 as seen in S. pneumoniae. Residues 67-476 are 34% similar to >gi16762149 as seen in Salmonella enterica.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1591 (0.0).","

InterPro
IPR003445
Family

Cation transporter
PF02386	$\"[152-476]T$	TrkH

","BeTs to 12 clades of COG0168COG name: Potassium uptake system component TrkGFunctional Class: PThe phylogenetic pattern of COG0168 is amtkYqvcEB-h--gpol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 67-411 are 34% similar to a (PROTEOME COMPLETE POTASSIUM UPTAKE) protein domain (PD003400) which is seen in Q9L6L2_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 15 09:45:41 2006","Thu Feb 7 15:14:56 2002","Tue Aug 15 09:45:41 2006","Wed Apr 10 15:58:12 2002","","Thu Feb 7 15:14:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1557 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 10:47:27 2002","","No significant hits to the NCBI PDB database.","SMU.1709","","Residues 152 to 476 (E-value = 9.1e-47) place SMu1557 in the TrkH family which is described as Cation transport protein (PF02386)","Thu Feb 7 15:14:56 2002","24380083","","","Schlosser A, Meldorf M, Stumpe S, Bakker EP, Epstein W.TrkH and its homolog, TrkG, determine the specificity and kinetics of cation transport by the Trk system of Escherichia coli.J Bacteriol. 1995 Apr;177(7):1908-10.PMID: 7896723 ","","Wed Feb 27 10:49:34 2002","1","","","SMU.1709","163" "SMu1558","1621503","1621249","255","ATGAAAAAAGTATTGATTGCTCCGATTAAATTTTATCAAAAATTTATTTCTCCCATCTTTCCAGCTTCCTGTCGTTATCGGCCAACTTGTTCAGCCTATATGATAGAGGCAATTGAAAAACATGGTTTAAAAGGTTTTTTAATGGGGATTGCCCGTATTTTACGCTGTCATCCTTTTGTTGAGGGAGGTGAAGATCCTGTACCAAATCATTTTACCTTGCGAAGAAATAAAAAAGAAAAGCCGTCTAAATCATAA","10.70","10.56","9648","MKKVLIAPIKFYQKFISPIFPASCRYRPTCSAYMIEAIEKHGLKGFLMGIARILRCHPFVEGGEDPVPNHFTLRRNKKEKPSKS","1621265","","conserved hypothetical protein","Periplasm, Membrane, Extracellular","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-77 are 74% similar to >gi|15674519 as seen in S. pyogenes. Residues 1-78 are 66% similar to >gi|15901701 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1592 (6e-33).","

InterPro
IPR002696
Family

Protein of unknown function DUF37
PD004225	$\"[5-69]T$	DUF37
PF01809	$\"[1-67]T$	DUF37
TIGR00278	$\"[5-78]T$	DUF37

","BeTs to 9 clades of COG0759COG name: Uncharacterized ACR, YidD familyFunctional Class: SThe phylogenetic pattern of COG0759 is -----qvcebrhuj--o-in-Number of proteins in this genome belonging to this COG is 1","***** IPB002696 (Domain of unknown function DUF37) with a combined E-value of 1.4e-15. IPB002696 9-59 IPB002696 8-58","Residues 1-67 are 60% similar to a (PROTEOME COMPLETE 3'REGION RNPA) protein domain (PD004225) which is seen in Q9X1H3_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:49:49 2002","Thu Feb 7 15:17:57 2002","Tue Oct 8 17:49:49 2002","Tue Oct 8 17:49:49 2002","Thu Feb 7 15:17:57 2002","Tue Oct 8 17:49:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1558 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:49:49 2002","","No significant hits to the NCBI PDB database.","SMU.1710c","","Residues 1 to 67 (E-value = 1.9e-37) place SMu1558 in the DUF37 family which is described as Domain of unknown function DUF37 (PF01809)","Thu Feb 7 15:17:57 2002","24380084","","","","","","1","","","SMU.1710c","960" "SMu1559","1622225","1621503","723","ATGAGAATTAATAAATACATTGCACACGCAGGAGTAGCCAGTCGTCGAAAAGCAGAAGAACTCATCAAGCAGGGGCTGGTCACTCTTAATGGTCAAATGGTGACTGAATTGGCTACTACTGTTAAATCAGGCGATCGTGTCGAAGTTGAGGGACAACCTATCTATAATGAAGAAAAAGTTTACTATCTTCTCAATAAACCACGCGGAGTGATTTCTAGTGTTAGAGATGATAAGGGTCGTCAAACGGTTGTTGATTTATTACCTGAGGTTAAGGAGCGTATCTATCCTGTTGGTCGTTTAGATTGGGATACGTCTGGGCTTCTTATTTTAACCAATGATGGTGATTTTACAGATAAGATGCTTCATCCACGGCATGAAATTGATAAGGTCTACGTGGCGCGTGTTAAAGGACTTGCCAGTAAGGATAATCTGCGCCCTTTGACAAAAGGAATCGTTATTGATGGCAAAAAAACACAACCTGCCCGCTATCGTATTGTCAAGACGGATAGAGAAAAAAATAGATCTGTTGTGGAACTGACTATTCACGAAGGACGCAACCATCAAGTTAAAAAGATGTTTGAAGCAGTTGGTTTAATGGTTGATAAATTATCGCGTACTCGTTTTGGAACACTTGATTTATCGGGTCTTAATCCGGGAGAGGCTAGGCGCCTTAATAAAAAAGAAATCAGCCAGCTTTACAATGCTGCTGTTAATGAAAACTAA","10.50","12.21","27189","MRINKYIAHAGVASRRKAEELIKQGLVTLNGQMVTELATTVKSGDRVEVEGQPIYNEEKVYYLLNKPRGVISSVRDDKGRQTVVDLLPEVKERIYPVGRLDWDTSGLLILTNDGDFTDKMLHPRHEIDKVYVARVKGLASKDNLRPLTKGIVIDGKKTQPARYRIVKTDREKNRSVVELTIHEGRNHQVKKMFEAVGLMVDKLSRTRFGTLDLSGLNPGEARRLNKKEISQLYNAAVNEN","1621519","For other 'rlu' genes see SMu0580 (rluB); SMu0778 (rluD); SMu0953 (rluE) and SMu1772 (rluD).","ribosomal large subunit pseudouridine synthase B","Cytoplasm","Significant hits in gapped BLAST to hypothetical protein and ribosomal large subunit pseudouridine synthase B. Residues 1-236 are 84% similar to >gi15674518 as seen in S. pyogenes. Residues 1-239 are 85% similar to >gi15901702 a sseen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1593 (1e-120).","

InterPro
IPR000748
Domain

Pseudouridine synthase, Rsu
TIGR00093	$\"[65-226]T$	Psi__synth_RSU
PS01149	$\"[98-112]T$	PSI_RSU

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[1-47]T$	S4
SM00363	$\"[1-64]T$	S4
PS50889	$\"[1-67]T$	S4

InterPro
IPR006145
Domain

Pseudouridine synthase
PF00849	$\"[60-195]T$	PseudoU_synth_2

noIPR
unintegrated

unintegrated
PTHR21600	$\"[5-233]T$	PTHR21600
PTHR21600:SF2	$\"[5-233]T$	PTHR21600:SF2
SSF55120	$\"[59-233]T$	SSF55120
SSF55174	$\"[1-59]T$	SSF55174

","BeTs to 11 clades of COG1187COG name: Predicted pseudouridylate synthase family 1Functional Class: JThe phylogenetic pattern of COG1187 is -----QvCEBrHuj--olinxNumber of proteins in this genome belonging to this COG is 3","***** IPB000748 (Pseudouridine synthase, Rsu family) with a combined E-value of 5.3e-67. IPB000748A 2-27 IPB000748B 65-80 IPB000748C 97-129 IPB000748D 179-213***** IPB000613 (Pseudouridine synthase) with a combined E-value of 5.7e-10. IPB000613A 54-74 IPB000613B 97-136 IPB000613C 183-207","Residues 147-205 are 45% similar to a (COMPLETE PROTEOME SYNTHASE PSEUDOURIDINE) protein domain (PD350128) which is seen in Q9KCJ5_BACHD.Residues 131-228 are 63% similar to a (SYNTHASE COMPLETE PSEUDOURIDINE PROTEOME RIBOSOMAL) protein domain (PD003862) which is seen in Q9CG35_LACLA.Residues 91-129 are 82% similar to a (SYNTHASE PROTEOME COMPLETE PSEUDOURIDINE RIBOSOMAL) protein domain (PD033985) which is seen in Q9CG35_LACLA.Residues 1-67 are 68% similar to a (SYNTHASE COMPLETE PROTEOME PSEUDOURIDINE RIBOSOMAL) protein domain (PD004022) which is seen in Q9CG35_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 14 16:43:21 2006","Thu Sep 14 16:43:21 2006","Thu Sep 14 16:43:21 2006","Thu Apr 4 10:59:51 2002","Thu Feb 7 15:20:50 2002","Thu Feb 7 15:20:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1559 is paralogously related (blast p-value < 1e-3) to pseudouridylate synthases: SMu0580, SMu0778, and SMu0953.","Thu Feb 7 15:21:59 2002","","No significant hits to the NCBI PDB database.","SMU.1711c","","Residues 1 to 47 (E-value = 2.4e-15) place SMu1559 in the S4 family which is described as S4 domain (PF01479)Residues 60 to 195 (E-value = 2e-23) place SMu1559 in the PseudoU_synth_2 family which is described as RNA pseudouridylate synthase (PF00849)","Thu Sep 14 16:43:21 2006","","","","","","","1","","","SMU.1711c","443" "SMu1560","1622811","1622215","597","ATGACACCGCTATCAAAGATAGAAGCCTTGCTATTTGTAGCTGGTGAAGATGGGTTAAGTCTGCGCCAGTTGGCAACTTTATTAGATATACCTGTAACAGCATTGCTTCAGCAATTGGAAAAGATGGCTCAGAAATATGAAAGGGATGATAATTCTGCCTTATCTTTATTGGAGTCTTCCAAAACTTATAAATTAGTCACTAAAAAAGATTATGCGGATCTTTTACGGCAGTATTCTAAAACGCCGATTAATCAGAGCTTATCAAGAGCCAGTTTGGAAGTTCTCTCTATCATAGCTTATAAACAACCCATTACAAGAATTGAAGTTGATAATATTCGTGGGGTGAATTCTAGCAGTGCTATTTCAAAACTGCAAGCTTTTGATTTGATTCAAGAGGCTGGAAAAAAAGAGGTGCTTGGACGTCCTAATCTCTATGTTACTTCAGATTATTTTCTGGATTATATGGGAATCAATAGTTTAGAAGAATTGCCAGATGCTTCCAGTATTGAATTAAAAGATGAAGAGTTTACACTTTTTGATAATAAGGAAAACGAAGAACAAATAAGTGAAAATGTAAAGGAAGAAAATGAGAATTAA","4.40","-11.98","22343","MTPLSKIEALLFVAGEDGLSLRQLATLLDIPVTALLQQLEKMAQKYERDDNSALSLLESSKTYKLVTKKDYADLLRQYSKTPINQSLSRASLEVLSIIAYKQPITRIEVDNIRGVNSSSAISKLQAFDLIQEAGKKEVLGRPNLYVTSDYFLDYMGINSLEELPDASSIELKDEEFTLFDNKENEEQISENVKEENEN","1622231","","segregation and condensation protein B","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-183 are 68% similar to >gi15674517 as seen in S. pyogenes. Residues 1-187 are 66% similar to >gi15901703 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1594 (1e-71).","

InterPro
IPR005234
Family

Prokaryotic chromosome segregation and condensation protein ScpB
PF04079	$\"[5-166]T$	DUF387
TIGR00281	$\"[2-186]T$	ScpB

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[4-81]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:1.10.10.590	$\"[82-157]T$	G3DSA:1.10.10.590

","BeTs to 8 clades of COG1386COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1386 is a--k--vc-br---gp-l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-160 are 71% similar to a (PROTEOME COMPLETE MG214 PLASMID) protein domain (PD134294) which is seen in Q9EUQ6_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:49:16 2002","Fri Aug 18 13:59:57 2006","Fri Aug 18 13:59:57 2006","Tue Oct 8 17:49:16 2002","","Thu Feb 7 15:24:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1560 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:49:16 2002","","No significant hits to the NCBI PDB database.","SMU.1712c","","Residues 5 to 166 (E-value = 1.2e-76) place SMu1560 in the DUF387 family which is described as Putative transcriptional regulators (Ypuh-like) (PF04079)","Thu Feb 7 15:24:03 2002","24380086","","","","","","1","","","SMU.1712c","710" "SMu1561","1623515","1622808","708","ATGGATATTAAATTAAAAGATTTTGAGGGACCGTTAGATTTACTTTTGCATTTGGTCTCTAAGTACGAAGTAGATATTTATGACGTTCCGATTGTAGATATTATTGAGCAATATCTAGCCTATATTGCAACGCTGCAAGCCATGAAGCTTGAAGTAGCTGGAGAATACATGGTTATGGCCAGTCAGTTAATGCTGATTAAAAGCCGTAAATTGCTTCCTAAAGTTGTTGAAACTATTGAAGCAGAAGAAGATCCAGAACTGCAACTCTTGCATCAAATTGAGGAATATCGAACTTACAAACTTTTAGGAGAGGAACTGGCCCTTAAACATAATGAAAGAGCACAGCGTTTTTCAAAACCCAAATTAGAACTCATTTATGACGATATAACACTTAAACAGGATAAAACTGTCCTTGATGTCTTTTTGGCTTTTTCAAAGGTAATGGCTGAAAAACAGGAAGAAATCAAAAACAGTCATACAACAATTAAAAGTGATGATTACCGGATTGAAGATATAATGACTGTAGTTGAAGAACAGGTAATTCGTCAAAAAGAAACCAATTTGTCTTGGTTTTTTAAAAGGGCCGGTTCGCTTAATGAGATAATTACTATCTTTTTAGCAGCTCTAGAGTTAATTAAAGTTCATCGTGTTTATGTTAAACAGGAACACAATTTTGATGACATCATTTTAAGGAAGGAGAGTGCATGA","4.90","-10.53","27547","MDIKLKDFEGPLDLLLHLVSKYEVDIYDVPIVDIIEQYLAYIATLQAMKLEVAGEYMVMASQLMLIKSRKLLPKVVETIEAEEDPELQLLHQIEEYRTYKLLGEELALKHNERAQRFSKPKLELIYDDITLKQDKTVLDVFLAFSKVMAEKQEEIKNSHTTIKSDDYRIEDIMTVVEEQVIRQKETNLSWFFKRAGSLNEIITIFLAALELIKVHRVYVKQEHNFDDIILRKESA","1622824","","segregation and condensation protein A","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-233 are 58% similar to >gi15903733 as seen in S. pneumoniae. Residues 1-233 are 57% similar to >gi11967873 as seen in S. mitis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1595 (6e-77).","

InterPro
IPR003768
Family

Prokaryotic chromosome segregation and condensation protein ScpA
PF02616	$\"[18-124]T$ $\"[197-233]T$	ScpA_ScpB

","BeTs to 6 clades of COG1354COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1354 is am-k-qvc-br---gp-l---Number of proteins in this genome belonging to this COG is 1","***** IPB003768 (DUF173) with a combined E-value of 5.5e-17. IPB003768A 28-39 IPB003768B 60-78 IPB003768E 202-230","Residues 4-222 are 58% similar to a (PROTEOME COMPLETE MATCH YNAH) protein domain (PD013752) which is seen in Q9EUQ7_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:48:33 2002","Thu Aug 31 14:58:56 2006","Thu Aug 31 14:33:21 2006","Tue Oct 8 17:48:33 2002","Thu Feb 7 15:26:09 2002","Thu Feb 7 15:26:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1561 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:48:33 2002","","No significant hits to the NCBI PDB database.","SMU.1713c","","Residues 18 to 233 (E-value = 1.1e-19) place SMu1561 in the DUF173 family which is described as Uncharacterised ACR, COG1354 (PF02616)","Thu Feb 7 15:26:09 2002","24380087","","","","","","1","","","SMU.1713c","593" "SMu1562","1624252","1623515","738","ATGATAACTTTTATTTCTAAATTTCTTGCCAGTAAATCCTTAACATTGAATTCGCAAAAATCTTATCTTTATGATCTGCAACAATTTGCCGAAATTATTGGAGAGGAAGTGACTCCCAATAAGCTTAAATTGTATGAGCAATCTTTGGCTGACTTAAAGGTTTCTGCTAAAAAACGTAAGATTTCGGCAGTCAATCAATTTCTGTTTTTCCTTTATGAAAATGAAGTATTGGATCGTTTTTATAAAATTAAAAATAAAGAAAAACTGCCGCTTTTGACGCCTGCTTATCAGGAAGTGGATTTATCCGTTCTCTACCGGAAAATAGGGGATTCTAAGGGGCAGTTGATTGCTCTTTTAATTGTAGAATTAGGCTTATCACCAAGTGAGATTATTCAATTAAAATGGGAAAATATTGCATTAGAATTCCAAGTCTTAACAATAGTCAATGAAAAAGTTATGAGAATTTTAGAGATTCCTCAACTGTTACTACCTTATCTTGAGGGAGAGCACAAGGCTGTTTATTTATTTGATAATAAAGGTGAAGCCTACTCACGTCAATGGCTTTTTCAAAAACTGAATTATTATTTGGCTTCTGTTGATTTGTCCCAAATGACAGCTCAAAAATTACGTGAACAATATATTATAAAAGAAAAAAATAAAGGGACTGCTATTTTGGATTTAACCAGAAAGCTTGGTCTTAAAAGCCCAGTAACATTGGAAAAATATTTTAAAAACTAA","10.10","7.25","28501","MITFISKFLASKSLTLNSQKSYLYDLQQFAEIIGEEVTPNKLKLYEQSLADLKVSAKKRKISAVNQFLFFLYENEVLDRFYKIKNKEKLPLLTPAYQEVDLSVLYRKIGDSKGQLIALLIVELGLSPSEIIQLKWENIALEFQVLTIVNEKVMRILEIPQLLLPYLEGEHKAVYLFDNKGEAYSRQWLFQKLNYYLASVDLSQMTAQKLREQYIIKEKNKGTAILDLTRKLGLKSPVTLEKYFKN","1623531","","tyrosine recombinase","Cytoplasm","Significant hits in gapped BLAST to integrase/recombinase and hypothetical proteins. Residues 1-245 are 46% similar to >gi15674515 as seen in S. pyogenes. Residues 5-242 are 41% similar to >gi15901705 as seen in S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1596 (1e-59).","

InterPro
IPR010998
Domain

Integrase, Lamba-type, N-terminal
SSF47823	$\"[1-79]T$	L_intgrse_like_N

InterPro
IPR011010
Domain

DNA breaking-rejoining enzyme, catalytic core
SSF56349	$\"[94-244]T$	DNA_brk_join_enz

InterPro
IPR013762
Domain

Integrase-like, catalytic core, phage
G3DSA:1.10.443.10	$\"[112-244]T$	Phage_intgr_like

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 5-242 are 41% similar to a (INTEGRASE PROTEOME COMPLETE) protein domain (PD407859) which is seen in Q9EUQ8_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:47:26 2002","Thu Jul 13 16:33:29 2006","Thu Jul 13 16:24:07 2006","Thu Feb 7 15:28:23 2002","","Thu Feb 7 15:28:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1562 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:47:26 2002","","No significant hits to the NCBI PDB database.","SMU.1714c","","No significant hits to the Pfam 11.0 database","Thu Feb 7 15:28:23 2002","24380088","","","","","","1","","","SMU.1714c","841" "SMu1563","1624710","1624249","462","ATGATTGCACAAGAATTTAAAGATTTTCTAAAACCACTTTTGAAAGATGCCCTCACTCCGGCTGAGGAATTAGCTATTTTTATTGATACTCATAAGACTGATCATGTTATGCTGCTGTTAGCTAATAATGGTTTTTCACGTGTCCCTGTTCTGACTAAGGATAAAAAATATGTAGGCACTATTAGTATGTCTGATATTGTTAAATATCAAAAAGAAGAGGGGGTAGATAATGAAAAGTTAGCAGCCCTAGACATTTCTTATATGACTAACGGTAGTTATGCTACTGTGAGTCCTAATGCCGATCTAACAGAAGTCATGCATAAATTAGTTGATGCTAATTTTCTTCCTGTTGTTGAAGCAGATGGTACTTTTTTAGGTATTATTACACGAAAAACAATTTTAAAAGCCTTAAATAACTTGCTTCATGAATTTACAAATGACTATACATTGACTAAAAAATGA","5.70","-3.04","17105","MIAQEFKDFLKPLLKDALTPAEELAIFIDTHKTDHVMLLLANNGFSRVPVLTKDKKYVGTISMSDIVKYQKEEGVDNEKLAALDISYMTNGSYATVSPNADLTEVMHKLVDANFLPVVEADGTFLGIITRKTILKALNNLLHEFTNDYTLTKK","1624265","","CBS domain protein","Cytoplasm, Extracellular","Significant hits in gapped BLAST to hypothetical protein and CBS domain protein. Residues 1-153 are 57% similar to >gi15674514 as seen in S. pyogenes. Residues 1-150 are 52% similar to >gi15901706 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1597 (3e-45).","

InterPro
IPR000644
Domain

Cystathionine-beta-synthase
PF00571	$\"[35-138]T$	CBS
SM00116	$\"[23-71]T$ $\"[92-138]T$	CBS

noIPR
unintegrated

unintegrated
PTHR11911	$\"[39-137]T$	PTHR11911
PTHR11911:SF5	$\"[39-137]T$	PTHR11911:SF5
SSF54631	$\"[6-76]T$ $\"[86-139]T$	SSF54631

","BeTs to 9 clades of COG0517COG name: CBS domainsFunctional Class: RThe phylogenetic pattern of COG0517 is AMTKYQVCEBRHUJgpo-inxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 69-150 are 54% similar to a (PROTEOME YNBB COMPLETE) protein domain (PD407126) which is seen in Q9EUQ9_STRPN.Residues 1-66 are 51% similar to a (PROTEOME YNBB COMPLETE) protein domain (PD412933) which is seen in Q9EUQ9_STRPN.Residues 20-141 are 30% similar to a (PROTEOME COMPLETE YKUL BH1482) protein domain (PD033629) which is seen in Q9KCT7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 15:32:35 2002","Thu Jul 13 16:43:57 2006","Thu Jul 13 16:43:57 2006","Tue Oct 8 17:46:29 2002","","Thu Feb 7 15:31:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1563 is paralogously related (blast p-value < 1e-3) to SMu1416, a conserved hypothetical protein.","Thu Feb 7 15:32:35 2002","","No significant hits to the NCBI PDB database.","SMU.1715c","","Residues 18 to 71 (E-value = 1.9e-05) place SMu1563 in the CBS family which is described as CBS domain (PF00571)Residues 87 to 138 (E-value = 7.2e-09) place SMu1563 in the CBS family which is described as CBS domain (PF00571)","Thu Jul 13 16:43:57 2006","24380089","","","","","","1","","","SMU.1715c","842" "SMu1564","1625225","1624707","519","ATGGCAGAACGCACATTAATTATCATGAGTGATTCTCATGGTGATCAACAAATTGTTCAGGAGATAAAAAATCGTTACTTAGGTAAAGTGGATGCTATTTTTCATAATGGAGATTCAGAGTTATCTGTTAATGATCCTATTTGGGAAGGGATTCATGTTGTTTGTGGGAATTGCGACTTTGGCGATTATCCCGATTGTTTGGTAACAAATTTTCCTGAATTGCTAGTAGCACAGACACATGGTCACCTATTTAATATTAATTTTGGCTTTGAACGTCTGGATTTGTGGGCTCAAGAGGAAGATGCTGATATCTGTACTTATGGACATCTTCATAGACCAGCTGTTTGGAAGAATGGGAAAACAGTTTTTATCAATCCAGGAAGCATTTCCCAGCCGCGTGGTGAGATTAATGAATGTCTTTATGCTAAAGTACGTGTCAATGCTGATACTATTTTTGTTGACTATTTGACGCGAGACCACAAGCTCTATACAGCACTTTCACAGGAAATAAAAAGATGA","5.10","-8.31","19606","MAERTLIIMSDSHGDQQIVQEIKNRYLGKVDAIFHNGDSELSVNDPIWEGIHVVCGNCDFGDYPDCLVTNFPELLVAQTHGHLFNINFGFERLDLWAQEEDADICTYGHLHRPAVWKNGKTVFINPGSISQPRGEINECLYAKVRVNADTIFVDYLTRDHKLYTALSQEIKR","1624723","","possible phosphoesterase","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 1-172 are 64% similar to >gi15674513 as seen in S. pyogenes. Residues 1-172 are 60% similar to >gi15903736 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1598 (1e-63).","

InterPro
IPR000979
Family

Protein of unknown function UPF0025
PIRSF000886	$\"[4-164]T$	VPS29
TIGR00040	$\"[4-154]T$	yfcE

InterPro
IPR004843
Domain

Metallophosphoesterase
PF00149	$\"[4-113]T$	Metallophos

noIPR
unintegrated

unintegrated
G3DSA:3.60.21.10	$\"[5-137]T$	G3DSA:3.60.21.10
PTHR11124	$\"[47-128]T$	PTHR11124
SSF56300	$\"[1-169]T$	SSF56300

","BeTs to 9 clades of COG0622COG name: Predicted phosphoesteraseFunctional Class: RThe phylogenetic pattern of COG0622 is AMTKy-V-eb----gp-l---Number of proteins in this genome belonging to this COG is 1","***** IPB000979 (Uncharacterized protein family UPF0025) with a combined E-value of 1.2e-20. IPB000979A 4-13 IPB000979B 28-38 IPB000979C 49-59 IPB000979D 93-133","Residues 8-142 are 47% similar to a (PROTEOME COMPLETE MG207 YNBC) protein domain (PD179616) which is seen in Q9CG30_LACLA.Residues 8-133 are 32% similar to a (PROTEOME COMPLETE PH1746 MJ0936) protein domain (PD006202) which is seen in Q9V1W7_PYRAB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:44:49 2002","Fri Aug 18 14:10:14 2006","Fri Aug 18 14:10:14 2006","Tue Oct 8 17:44:49 2002","Thu Feb 7 15:34:43 2002","Thu Feb 7 15:34:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1564 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:44:49 2002","","No significant hits to the NCBI PDB database.","SMU.1716c","","No significant hits to the Pfam 11.0 database","Thu Feb 7 15:34:43 2002","24380090","","","","","","1","","","SMU.1716c","711" "SMu1565","1626184","1625207","978","ATGAAAGAAAAAATTTATGAATATAAAGATGATCATAACTGGTTCATTAGCCAATGGTCTAAAGTAGGCTCCTCAACTTACTATGAGGAAGAGGCAGAAGAAACTTACAGTTCTATTGAACAAAGTCTTAGAGGTTTACTTGATGAAGGCAATTCGTTTATACTGACAGTTATTAAAATCAACTCCAACATAGCTCTTGTACGTTTTATCTTAAAAATGCTTAATGAAGAGCAACAAGATAATTTTAAAGTCAGCAGTCATAAAGGAGCTATTTTAGTGACACAGGGACAACAGTTGCTTTTAGTTTGTTTGCCAAAAAAAGGCATAACTATAACCGATTTTTTTGAAAAGGAAAAAAAGGTTTCTGAATTAGGAGATACTATTTTAATTGCCACACGCAACGAAGGTAAAACCAAGGAATTCAGTCAAATGTTCGCTCAATTAGGAATAAAAGTTGAAAATCTTAATCAATATCCTGATTTGCCCGAGGTAGAAGAAACCGGTCTAACCTTTGAAGAAAACGCTCGTTTGAAAGCAGAGACCATTTCTCATTTGACAGGGCAGATGGTTTTGGCAGATGATTCAGGGTTGAAGGTAGATGTTTTAGGTGGTTTACCGGGAATCTGGTCAGCTCGTTTTTCGGGACTTGATGCAACAGATCAAAGTAATAATGCTAAATTACTACATGAACTCGCTATGGTTTTTGATATCAAGGATCGTTCCGCTCAGTTTCATACAACTTTGGTTGTAGCTGCTCCAGATAAGGAAAGCCTTGTGGTTGAAGCAGATTGGTCTGGATACATTGATTTTGCTCCTAAAGGGAATAATGGTTTTGGCTATGATCCTTTGTTTTTAGTGGGAGAAACAGGGAAGACCGCAGCAGAACTTTCAAATCACGAAAAAAATATTATTTCTCACAGAGGACAAGCTGTTAAGAAGCTTATGGAGGTATTTCCAGCATGGCAGAACGCACATTAA","4.90","-13.09","36385","MKEKIYEYKDDHNWFISQWSKVGSSTYYEEEAEETYSSIEQSLRGLLDEGNSFILTVIKINSNIALVRFILKMLNEEQQDNFKVSSHKGAILVTQGQQLLLVCLPKKGITITDFFEKEKKVSELGDTILIATRNEGKTKEFSQMFAQLGIKVENLNQYPDLPEVEETGLTFEENARLKAETISHLTGQMVLADDSGLKVDVLGGLPGIWSARFSGLDATDQSNNAKLLHELAMVFDIKDRSAQFHTTLVVAAPDKESLVVEADWSGYIDFAPKGNNGFGYDPLFLVGETGKTAAELSNHEKNIISHRGQAVKKLMEVFPAWQNAH","1625223","","HAM1-like protein","Cytoplasm","Significant hits in gapped BLAST to hypothetical proteins. Residues 1-323 are 61% similar to >gi15903737 as seen in S. pneumoniae. Residues 1-322 are 61% similar to >gi15674512 as seen in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1599 (1e-107).","

InterPro
IPR002637
Family

Ham1-like protein
PTHR11067	$\"[124-325]T$	Ham1p_like
PF01725	$\"[128-318]T$	Ham1p_like
TIGR00042	$\"[127-319]T$	Ham1p_like

noIPR
unintegrated

unintegrated
PD457820	$\"[1-126]T$	PD457820
G3DSA:3.90.950.10	$\"[103-318]T$	G3DSA:3.90.950.10
PTHR11067:SF1	$\"[124-325]T$	PTHR11067:SF1
SSF52972	$\"[113-321]T$	SSF52972

","BeTs to 14 clades of COG0127COG name: Xanthosine triphosphate pyrophosphatase, HAM1/YggV familyFunctional Class: FThe phylogenetic pattern of COG0127 is amtkyqvcebrh----olin-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 132-211 are 37% similar to a (PROTEOME COMPLETE HAM1 HYDROLASE) protein domain (PD218601) which is seen in O28046_ARCFU.Residues 127-253 are 64% similar to a (PROTEOME COMPLETE HAM1 FAMILY) protein domain (PD330109) which is seen in Q9CG29_LACLA.Residues 266-319 are 64% similar to a (PROTEOME COMPLETE HAM1 FAMILY) protein domain (PD004952) which is seen in Q9CG29_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:43:57 2002","Thu Sep 14 16:58:45 2006","Thu Sep 14 16:58:45 2006","Tue Oct 8 17:43:57 2002","","Thu Feb 7 15:36:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1565 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:43:57 2002","","No significant hits to the NCBI PDB database.","SMU.1717c","","Residues 128 to 318 (E-value = 8.1e-71) place SMu1565 in the Ham1p_like family which is described as Ham1 family (PF01725)","Thu Feb 7 15:36:46 2002","24380091","","","","","","1","","","SMU.1717c","444" "SMu1566","1626975","1626181","795","ATGGATAATAGACCTATTGGTTTTTTAGACTCCGGAGTGGGCGGTTTAACGGTCGTACGTGAATTAATGCGTCAGCTTCCACATGAAGAGGTTATCTATATTGGGGATTCAGCGCGTGCACCTTATGGACCGCGTCCAGCTAAACAGATAAAGACATATACTTGGGAATTGGTCAACTTTCTCCTTACTAAAAAGGTTAAAATGATTGTTTTTGCTTGTAATACAGCAACGGCTGTTGTTTGGGAAGAGGTCAAAGAAAAACTTGATATTCCCGTTTTAGGTGTTATTTTACCAGGTTCTAGCGCTGCTATTAAATCAACTATTTCTGGTCAAATTGGCATTATTGGGACACCGATGACCATCAAATCTAATATTTATGAGCAAAAAATACGAGATCTCTCACCACAAATGAAAGTAAGAAGCCTAGCTTGCCCCAAATTTGTTCCTATTGTTGAATCAAATAAAATGAACTCAAGTGTAGCGAAAAAGATTGTTTATGAAAGTCTATCTCCTCTGGTGGGGAAAATTGATACTCTTGTTTTAGGCTGTACCCATTATCCACTTTTACGGCCCATTATTCAAAATGTAATGGGACCAGATGTTGAGTTAATTGATAGTGGTGCAGAATGTGTACGTGATATTTCTGTTCTCCTGAATTACTTTGATCTTAATCGCAGCAGAACTTCAAAAGTGCTGCATCATCGTTTCTATACAACAGCTAGTGTGGCCAGTTTTAAAGAAATAGCTAGCGACTGGTTACCTTTAGCTATTGAAGTGGAGCATGTAACATTATGA","8.80","5.02","29250","MDNRPIGFLDSGVGGLTVVRELMRQLPHEEVIYIGDSARAPYGPRPAKQIKTYTWELVNFLLTKKVKMIVFACNTATAVVWEEVKEKLDIPVLGVILPGSSAAIKSTISGQIGIIGTPMTIKSNIYEQKIRDLSPQMKVRSLACPKFVPIVESNKMNSSVAKKIVYESLSPLVGKIDTLVLGCTHYPLLRPIIQNVMGPDVELIDSGAECVRDISVLLNYFDLNRSRTSKVLHHRFYTTASVASFKEIASDWLPLAIEVEHVTL","1626197","For other 'mur' genes see SMu0549 (murF); SMu0653 (murN); SMu0654 (murM); SMu0883 (murB); SMu1529 (murE); SMu0498 (murD);SMu0499 (murG); SMu1577 (murC); SMu1304 (murC);SMu1386 (murA) and SMu1429 (murZ). ","glutamate racemase","Membrane, Cytoplasm","Significant hits in gapped BLAST to glutamate racemase. Residues 1-264 are 73% similar to >gi|15901709 as seen in S. pneumoniae. Residues 1-264 are 74% similar to >gi|15674511 as seen in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1600 (1e-107).","

InterPro
IPR001920
Family

Asp/Glu racemase
PF01177	$\"[5-219]T$	Asp_Glu_race
PS00924	$\"[179-189]T$	ASP_GLU_RACEMASE_2
SSF53681	$\"[4-108]T$ $\"[109-263]T$	Asp/Glu_race

InterPro
IPR004391
Family

Glutamate racemase
TIGR00067	$\"[6-255]T$	glut_race

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1860	$\"[4-149]T$	G3DSA:3.40.50.1860
PTHR21198	$\"[1-264]T$	PTHR21198

","BeTs to 8 clades of COG0796COG name: Glutamate racemaseFunctional Class: MThe phylogenetic pattern of COG0796 is -----q-ceBrhuj--ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 141-206 are 71% similar to a (RACEMASE GLUTAMATE ISOMERASE CELL) protein domain (PD004566) which is seen in MURI_LACLA.Residues 68-142 are 41% similar to a (GLUTAMATE RACEMASE ISOMERASE SYNTHESIS) protein domain (PD002869) which is seen in MURI_BACSU.Residues 209-264 are 54% similar to a (GLUTAMATE RACEMASE SYNTHESIS ALL) protein domain (PD348223) which is seen in MURI_LACLA.Residues 66-132 are 37% similar to a (RACEMASE ASPARTATE PROTEOME COMPLETE) protein domain (PD355676) which is seen in MURI_AQUPY.Residues 3-57 are 70% similar to a (RACEMASE GLUTAMATE ISOMERASE SYNTHESIS) protein domain (PD004303) which is seen in MURI_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 07:56:05 2002","Thu Feb 7 15:40:00 2002","Thu Oct 17 07:56:05 2002","Thu Apr 4 08:58:52 2002","","Thu Feb 7 15:40:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1566 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 11:02:45 2002","Thu Feb 7 15:40:00 2002","pdb|1B74|A Chain A, Glutamate Racemase From Aquifex Pyrophilus ... 159 3e-040","SMU.1718c","","Residues 5 to 219 (E-value = 1.7e-98) place SMu1566 in the Asp_Glu_race family which is described as Asp/Glu/Hydantoin racemase (PF01177)","Thu Feb 7 15:40:00 2002","","","","Glavas S, Tanner ME.Active site residues of glutamate racemase.Biochemistry. 2001 May 29;40(21):6199-204.PMID: 11371180Liu L, Yoshimura T, Endo K, Esaki N, Soda K.Cloning and expression of the glutamate racemase gene of Bacillus pumilus.J Biochem (Tokyo). 1997 Jun;121(6):1155-61.PMID: 9354391 ","","Wed Feb 27 11:02:45 2002","1","","","SMU.1718c","445" "SMu1567","1627276","1627028","249","ATGAATACTTTTCTTTGGATTCTATTAGTTATTATTGCCTTACTTGCAGGACTTGTGGGAGGCACTTTTATTGCTCGTAAGCAGATGGAAAAATATTTAGAAGAAAACCCACCACTTAACGAAGATGTTATTCGTAATATGATGAGTCAGATGGGTCAAAAACCAAGTGAAGCTAAAGTGCAACAAGTTGTTCGTCAGATGAATAAACAACAAAAAGCAGCTAAAGCAAAGGCTAAAAAGAAGAAATAA","11.00","8.98","9326","MNTFLWILLVIIALLAGLVGGTFIARKQMEKYLEENPPLNEDVIRNMMSQMGQKPSEAKVQQVVRQMNKQQKAAKAKAKKKK","1627044","","conserved hypothetical protein","Periplasm, Membrane","Significant hit in gapped BLAST to hypothetical protein. Residues 1-67 are 47% similar to >gi|15674510 as seen in S. pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1601 (1e-12).","

InterPro
IPR005359
Family

Protein of unknown function UPF0154
PD048972	$\"[5-67]T$	UPF0154
PF03672	$\"[8-71]T$	UPF0154

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 22-67 are 56% similar to a (TRANSMEMBRANE MG335.1 YNBE BH2350) protein domain (PD048972) which is seen in YNBE_LACLA.Residues 23-68 are 56% similar to a (TTK-CCDA TRANSMEMBRANE) protein domain (PD388765) which is seen in YNEF_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:43:11 2002","Thu Feb 7 15:41:38 2002","Tue Oct 8 17:43:11 2002","Thu Feb 7 15:41:38 2002","","Thu Feb 7 15:41:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1567 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:43:11 2002","","No significant hits to the NCBI PDB database.","SMU.1719c","","Residues 8 to 71 (E-value = 9.6e-32) place SMu1567 in the UPF0154 family which is described as Uncharacterised protein family (UPF0154) (PF03672)","Thu Feb 7 15:41:38 2002","24380093","","","","","","1","","","SMU.1719c","961" "SMu1568","1628899","1627649","1251","ATGAAAACACCATTTGTATCAAAAGAACAGCTAGATAAGATCACAGCACAGTTTCCAACCCCTTTTCACCTTTATGATGAAAAAGGCATACGAGAAACAGCTCGTGCTGTCAATAAAGCCTTTGCTTGGAATTCCGGTTTCAAGGAATTTTTTGCGGTTAAAGCAACACCTAATCCAACTATTTTAAAGATATTGCAAGAAGAAGGCTGTGGGGTAGATTGTGCGACTGATGTTGAGTTGAAGATGGCTGATAAACTTGGTTTCGATCGCTCTGCTATTAGTTTTACATCAAATGATACTCAGGCTTCAGAGTTTGTTTTTGCGCGCAGTATCAATGCAACGATTAATTTGGATGCCTATGAACATATTGCTTTCTTAGAAGAAGCAGCAGGACTTCCTGAAACGGTTTCTCTGCGTTTTAACCCCGGCGGTGTTTTTTCGCTTGGGACAGATATTATGGATCATCCTGAAGAGTCTAAATTTGGAATGACTAAGGAACAACTTTTCCAAGGCTATCAAGATTTGAAAGACAAAGGTGTTAAATCTTTTGGCCTACATGCTTTTTTGGCATCTAATACTGTTACTAATGATTATTATCCAACTTTAGCAGCTCAACTATTTGAATTAGCTGTTGAAATAAAAAATGAATTGGGTATCAGCCTTGATTTTATCAATTTGTCAGGTGGTATTGGTATTGATTACTCGGCAGCTGATGAACAAAATGATATTGCTGTTATTGGAGAGGGTGTTCATCAAAAATTTGATGATATTTTAGTTCCTAATGGGCTCAGTCAGATCAAAATTTATACAGAACTTGGACGCTATATGTTGGCTTCACATGGGCATCTGATTACTAAAGTGCTTCATTTAAAAGATACCTATCGTCATTATGTTGGTGTTGATGCCAGTGCTGTTAATCTTTTGCGTCCTGCCATGTATGATGCTTATCATCACATTACCAATATCAGCAACCCACAGGGAACTGTTCAAGTTGTTGATATTGTAGGCAGTTTGTGTGAGAATAATGATAAGTTTGCCAAACGGCGTGAATTGCCAGAAGCGCGTGTGGGTGATACACTTGTTATTCATGATACAGGTGCTCATGGCTTTTCAATGGGTTACAATTACAATGGTCGTTTACGCTCTGCGGAAATTTTACTCCGAGAAGACGGTCAAACTCAAATGATTCGTCGAGCAGAAACTCCAGAAGATTATTTTGCAACACTTTATGGCTTTAATTTTGATAGATAA","5.10","-14.98","46314","MKTPFVSKEQLDKITAQFPTPFHLYDEKGIRETARAVNKAFAWNSGFKEFFAVKATPNPTILKILQEEGCGVDCATDVELKMADKLGFDRSAISFTSNDTQASEFVFARSINATINLDAYEHIAFLEEAAGLPETVSLRFNPGGVFSLGTDIMDHPEESKFGMTKEQLFQGYQDLKDKGVKSFGLHAFLASNTVTNDYYPTLAAQLFELAVEIKNELGISLDFINLSGGIGIDYSAADEQNDIAVIGEGVHQKFDDILVPNGLSQIKIYTELGRYMLASHGHLITKVLHLKDTYRHYVGVDASAVNLLRPAMYDAYHHITNISNPQGTVQVVDIVGSLCENNDKFAKRRELPEARVGDTLVIHDTGAHGFSMGYNYNGRLRSAEILLREDGQTQMIRRAETPEDYFATLYGFNFDR","1627665","For other 'lys' genes see SMu0701 (lysS) and SMu1594 (lysC). ","diaminopimelate decarboxylase","Cytoplasm","Significant hits in gapped BLAST to diaminopimelate decarboxylase. Residues 1-415 are 68% similar to >gi|15901801 and >gi|15903834 as seen in S. pneumoniae. Residues 1-414 are 67% similar to >gi|15673266 as seen in L. lactis.SMu1568 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000183
Domain

Orn/DAP/Arg decarboxylase 2
PR01179	$\"[51-69]T$ $\"[71-83]T$ $\"[268-287]T$ $\"[366-379]T$	ODADCRBXLASE
PF00278	$\"[282-387]T$	Orn_DAP_Arg_deC
PF02784	$\"[26-279]T$	Orn_Arg_deC_N

InterPro
IPR002986
Domain

Diaminopimelate decarboxylase
PR01181	$\"[69-86]T$ $\"[154-163]T$ $\"[295-313]T$ $\"[376-398]T$	DAPDCRBXLASE

InterPro
IPR009006
Domain

Alanine racemase/group IV decarboxylase, C-terminal
SSF50621	$\"[250-406]T$	Racem_decarbox_C

noIPR
unintegrated

unintegrated
G3DSA:3.20.20.10	$\"[27-278]T$	G3DSA:3.20.20.10
PTHR11482	$\"[5-416]T$	PTHR11482
PTHR11482:SF5	$\"[5-416]T$	PTHR11482:SF5
SSF51419	$\"[26-281]T$	SSF51419

","BeTs to 11 clades of COG0019COG name: Diaminopimelate decarboxylaseFunctional Class: EThe phylogenetic pattern of COG0019 is amt-yQVCebrhUJ-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 334-381 are 54% similar to a (DECARBOXYLASE ORNITHINE LYASE BIOSYNTHESIS PYRIDOXAL) protein domain (PD001257) which is seen in DCDA_METJA.Residues 20-139 are 45% similar to a (DECARBOXYLASE ORNITHINE LYASE BIOSYNTHESIS PYRIDOXAL) protein domain (PD001258) which is seen in TABA_PSESZ.Residues 326-401 are 38% similar to a (DECARBOXYLASE) protein domain (PD244080) which is seen in Q9RL03_STRCO.Residues 133-214 are 73% similar to a (PROTEOME COMPLETE DIAMINOPIMELATE) protein domain (PD393400) which is seen in Q9CG26_LACLA.Residues 21-121 are 72% similar to a (PROTEOME DIAMINOPIMELATE COMPLETE) protein domain (PD414684) which is seen in Q9CG26_LACLA.Residues 216-311 are 70% similar to a (DECARBOXYLASE DIAMINOPIMELATE LYASE) protein domain (PD312460) which is seen in Q9CG26_LACLA.Residues 334-409 are 73% similar to a (DECARBOXYLASE DIAMINOPIMELATE LYASE) protein domain (PD115551) which is seen in Q9CG26_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 07:54:48 2002","Thu Feb 7 15:44:11 2002","Thu Oct 17 07:54:48 2002","Thu Apr 4 14:30:45 2002","","Thu Feb 7 15:44:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1568 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 11:09:02 2002","Thu Feb 7 15:44:11 2002","pdb|7ODC|A Chain A, Crystal Structure Ornithine Decarboxylase F... 66 8e-012","SMU.1721c","","Residues 26 to 279 (E-value = 5.3e-20) place SMu1568 in the Orn_Arg_deC_N family which is described as Pyridoxal-dependent decarboxylase, pyridoxal binding domain (PF02784)Residues 282 to 388 (E-value = 3.2e-42) place SMu1568 in the Orn_DAP_Arg_deC family which is described as Pyridoxal-dependent decarboxylase, C-terminal sheet domain (PF00278)","Thu Feb 7 15:44:11 2002","24380094","","","Engst,K. and Shaw,P.D.Identification of a lysA-like gene required for tabtoxinbiosynthesis and pathogenicity in Pseudomonas syringae pv. tabacistrain PTBR2.024Mol. Plant Microbe Interact. 5 (4), 322-329 (1992)PubMed: 1515668Kal'cheva EO, Shanskaia VO, Maliuta SS.[Cloning and regulation of the expression of the lysA gene from Bacillus subtilis]Genetika. 1992 May;28(5):5-10. Russian.PMID: 1639261","","Thu Oct 17 07:54:48 2002","1","","","SMU.1721c","" "SMu1569","1629777","1629088","690","ATGAATAATAACACAATTTACACACAAAGTGATAGCAGGCTTAGCAGTTTTTTTGCTAAGATTTATGGTTTAGTTGGCATGGGAATTGGGCTATCAGCAGTCGTTTCTTATCTCATGCTCTATGTTTTTCGCAATAACATGATAGCTATTATGGTTAATGCGCCTTGGGTTTACTATGTTGCTATCTTCGCAGAACTGGCGCTTGTTTTAATAGCAAGCAACGCAGCACGTAAGAATAGTCCTACAGCTTTACCATTGTTTTTGGTTTATTCAGCTTTAAATGGCTTTACTTTGAGCTTTATTATTGCTCTTTATACCCAAACAACGGTTTTACAAGCCTTTGTTTCATCAGCAGCTGTTTTCTTTGTTATGGCACTTATTGGAGTGACCATTAAAAAAGATTTATCTGGAATGGGTAAAGCTTTGCTTGCTGCTTTAATTGGTATCATTATTGCCAGCCTTATTAATATGTTTATCGGCAGCGGAACAATGAGCTATGTCATTAGTATTATTTCAGTCTTGATTTTTTCTGGATTGATTGCTTATGATAATCAATTGATTAAGCGTGTATATGACTATAATAGTGGAAATGTCAGTGACGGTTGGGCAGTATCAATGGCTCTCAATCTTTACTTAGACTTTATCAATCTGTTTCTTAGTTTACTTCGTATCTTTGGAAGAAATGATTAA","10.20","3.98","24982","MNNNTIYTQSDSRLSSFFAKIYGLVGMGIGLSAVVSYLMLYVFRNNMIAIMVNAPWVYYVAIFAELALVLIASNAARKNSPTALPLFLVYSALNGFTLSFIIALYTQTTVLQAFVSSAAVFFVMALIGVTIKKDLSGMGKALLAALIGIIIASLINMFIGSGTMSYVISIISVLIFSGLIAYDNQLIKRVYDYNSGNVSDGWAVSMALNLYLDFINLFLSLLRIFGRND","1629104","","conserved hypothetical protein, membrane protein","Membrane, Extracellular","Significant hits in gapped BLAST to conserved hypothetical proteins and membrane proteins. Residues 1-229 are 68% similar to >gi15674509 as seen in S. pyogenes. Residues 1-229 are 54% similar to >gi15903829 and >gi15901795 as seen in S. pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1604 (7e-86).","

InterPro
IPR006214
Family

Protein of unknown function UPF0005
PTHR23291	$\"[9-229]T$	UPF0005
PF01027	$\"[10-229]T$	UPF0005

noIPR
unintegrated

unintegrated
PTHR23291:SF6	$\"[9-229]T$	PTHR23291:SF6

","BeTs to 8 clades of COG0670COG name: Integral membrane protein YccA, interacts with FtsHFunctional Class: RThe phylogenetic pattern of COG0670 is ----y--cEb-huj--o-inxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 95-226 are 49% similar to a (PROTEOME COMPLETE TRANSPORT PERMEASE) protein domain (PD035975) which is seen in Q9CEU8_LACLA.Residues 2-92 are 39% similar to a (PROTEOME COMPLETE TRANSPORT PERMEASE) protein domain (PD393347) which is seen in Q9CEU8_LACLA.Residues 95-226 are 35% similar to a (TRANSMEMBRANE INHIBITOR-1 BAX APOPTOSIS) protein domain (PD241206) which is seen in O31539_BACSU.Residues 25-224 are 27% similar to a (PROTEOME COMPLETE) protein domain (PD103291) which is seen in P73793_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 07:52:46 2002","Thu Aug 31 15:05:49 2006","Thu Aug 31 15:05:49 2006","Thu Oct 17 07:52:46 2002","","Thu Feb 7 15:47:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1569 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 07:52:46 2002","","No significant hits to the NCBI PDB database.","SMU.1722c","","Residues 10 to 229 (E-value = 2.8e-21) place SMu1569 in the UPF0005 family which is described as Uncharacterised protein family UPF0005 (PF01027)","Thu Feb 7 15:47:00 2002","24380095","","","","","","1","","","SMU.1722c","594" "SMu1570","1630300","1629797","504","ATGAAGAAGTATGAACAAGATGAAGAATTCATGAGTCTTGTAGGACCTTTAATTGACCATCCGCGGTTTCAAAAATTGGAAGGTATTATACAGCATCACCATTCTACGCGCTCAGAACATTCCATTAATGTAAGCTATACTAGTTATAGGATTGCTAAAAAATTTGGTTGGGATGCTAAGAGTACGGCTCGTGGCGGTTTGTTACATGACCTATTTTATTATGATTGGCGAGATACTAAGTTCAATAAAGGTCATGCCTGGGTTCATCCAAGAATTGCTGTAAAAAATGCTCGTAAGGTAACCAAGCTTAATCAAAAAGAAGAAGACATCATTTTAAAACACATGTGGGGAGCAACCATAGCTCCACCGCGTTACAAAGAGGGTTATATCGTAACTATGGTTGATAAATATTGGGCTGTAAAAGAGGCGATAACCCCTTTAAGAATGAAATGGCAAAAACGCCGTATCTTTCGTCGTAAGTTTTTAGGCAGTCACAATCATTAG","10.90","17.63","19975","MKKYEQDEEFMSLVGPLIDHPRFQKLEGIIQHHHSTRSEHSINVSYTSYRIAKKFGWDAKSTARGGLLHDLFYYDWRDTKFNKGHAWVHPRIAVKNARKVTKLNQKEEDIILKHMWGATIAPPRYKEGYIVTMVDKYWAVKEAITPLRMKWQKRRIFRRKFLGSHNH","1629813","","conserved hypothetical protein","Cytoplasm","Significant hits in gapped BLAST to conserved hypothetical proteins. Residues 4-166 are 79% similar to >gi|15674508 as seen in S. pyogenes. Residues 2-159 are 58% similar to >gi|15673720 as seen in L. lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1605 (1e-80).","

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[33-149]T$	HDc

","BeTs to 4 clades of COG1418COG name: Uncharacterized hydrolases of the HD superfamilyFunctional Class: RThe phylogenetic pattern of COG1418 is Amtk-qv-eB--ujgpol---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 2-159 are 58% similar to a (PROTEOME YRJG COMPLETE) protein domain (PD399234) which is seen in Q9CEU6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:42:19 2002","Thu Feb 7 15:48:59 2002","Tue Oct 8 17:42:19 2002","Tue Oct 8 17:42:19 2002","","Thu Feb 7 15:48:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1570 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:42:19 2002","","No significant hits to the NCBI PDB database.","SMU.1723c","","No significant hits to the Pfam 11.0 database","Thu Feb 7 15:48:59 2002","24380096","","","","","","1","","","SMU.1723c","712" "SMu1571","1631075","1630335","741","ATGACTATTATAACCTCAAAAGCCAATTCCTTGATTAAAAAAACTAAAAAATTATTACAAAAAAAATACCGTCAATATTCCTATTTGATTGAAGGTTGGCATTTATTTGCAGAAGCACAAGCCAACAATGCTGATATTATTAATATTTTTGTCCTAGAGTGTTATGCTTCTAGAGTATCTGAGTTTCCCAATGTTGTTCTAGTATCAGAGGATATTTTAAAAGACTTATCTGCTTCAAAGACTCCTCAAGGTATTGTTGCTGAAATAGCTTTTCCTAAGCAAGTAATTCCTCAGCAGTTCTTTGGAAAATATCTGCTTTTGGAAGACGTTCAAGATCCAGGAAATGTAGGAACAATCATTCGGACAGCAGATGCAGCAGCTTTTGATGCTGTTTTTGTGTCAGAAAAGACAGCAGATATTTATAATTCCAAGACTCTTCGTTCAATGCAGGGTAGCCATTTTCATCTTCCTATTTATAGAGTCAATCTTTTATCTTTAGTGAATGATTTAAAAAATGCAGATGTTACTACCATTGCGACCACACTATCTGATCATTCCTGTGACTATAAGTCTTTAAAAAAGGTTGAAAATTTTGCGCTTATTATGGGAAATGAAGGGCAAGGCATTACTTCAGAAATGACTGAACAAGCAGATGTTTTGACCCATATCACTATGCCTGGAAGAGCAGAAAGCTTAAATGTAGCAGCTGCTGCAGCTATATTTATTTTTAGCTTAATTTAA","6.40","-1.89","27183","MTIITSKANSLIKKTKKLLQKKYRQYSYLIEGWHLFAEAQANNADIINIFVLECYASRVSEFPNVVLVSEDILKDLSASKTPQGIVAEIAFPKQVIPQQFFGKYLLLEDVQDPGNVGTIIRTADAAAFDAVFVSEKTADIYNSKTLRSMQGSHFHLPIYRVNLLSLVNDLKNADVTTIATTLSDHSCDYKSLKKVENFALIMGNEGQGITSEMTEQADVLTHITMPGRAESLNVAAAAAIFIFSLI","1630351","","rRNA methyltransferase","Cytoplasm, Membrane","Significant hits in gapped BLAST to rRNA methylase. Residues 3-246 are 52% similar to >gi15674507 as seen in S. pyogenes. Residues 1-234 are 54% similar to >gi15903830 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1606 (2e-68).","

InterPro
IPR001537
Domain

tRNA/rRNA methyltransferase, SpoU
PD001243	$\"[105-234]T$	SpoU_mtfrase
PF00588	$\"[102-243]T$	SpoU_methylase

InterPro
IPR013123
Domain

RNA 2-O ribose methyltransferase, substrate binding
PF08032	$\"[29-95]T$	SpoU_sub_bind

noIPR
unintegrated

unintegrated
G3DSA:3.30.1330.30	$\"[2-93]T$	G3DSA:3.30.1330.30
G3DSA:3.40.1280.10	$\"[102-243]T$	G3DSA:3.40.1280.10
PTHR12029	$\"[64-246]T$	PTHR12029
PTHR12029:SF8	$\"[64-246]T$	PTHR12029:SF8
SSF55315	$\"[2-94]T$	SSF55315
SSF75217	$\"[85-246]T$	SSF75217

","BeTs to 14 clades of COG0566COG name: rRNA methylasesFunctional Class: JThe phylogenetic pattern of COG0566 is a---YQvCEBRHujgpOLinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 150-234 are 50% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE RRNA TRNA/RRNA) protein domain (PD001243) which is seen in Q9CHW1_LACLA.Residues 68-146 are 45% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE RRNA) protein domain (PD016373) which is seen in Q9CHW1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 15:51:38 2002","Thu Aug 31 15:17:33 2006","Thu Aug 31 15:17:33 2006","Thu Oct 17 07:49:07 2002","","Thu Feb 7 15:51:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1571 is paralogously related (blast p-value < 1e-3) to SMu0147, a predicted tRNA/rRNA methyltransferase.","Thu Feb 7 15:51:38 2002","","No significant hits to the NCBI PDB database.","SMU.1724c","","Residues 102 to 243 (E-value = 1e-29) place SMu1571 in the SpoU_methylase family which is described as SpoU rRNA Methylase family (PF00588)","Thu Feb 7 15:51:06 2002","24380097","","","","","","1","","","SMU.1724c","595" "SMu1572","1631108","1631386","279","ATGAAAAAAGTCAGATTACTAGTCTCTGGTCGTGTTCAAGGTGTCGGTTTTCGCTATTCTACCTATAATCTCGCTTTAGAAATAGGGGATATTTATGGACGTGTTTGGAACAATGATGATGGAACAGTAGAAATTCTAGCTCAGTCAGATAATGCTGAAAAACTAGCTAAGTTTATTCAAGAAATTCGCAAAGGTCCATCTCCTTTTTCTAAAGTCACTTATGTTGACGTCAATATAGCAAATTTTTCTGATTACCATGATTTCAGAATGGCCAATTAA","9.10","1.23","10446","MKKVRLLVSGRVQGVGFRYSTYNLALEIGDIYGRVWNNDDGTVEILAQSDNAEKLAKFIQEIRKGPSPFSKVTYVDVNIANFSDYHDFRMAN","1631396","","acylphosphatase","Cytoplasm","Significant hits in gapped BLAST to acylphosphatase. Residues 1-90 are 73% similar to >gi|15674506 as seen in S. pyogenes. Residues 1-92 are 695 similar to >gi|15903831 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1607 (7e-39).","

InterPro
IPR001792
Domain

Acylphosphatase
PD001884	$\"[4-89]T$	Acylphosphatase
PF00708	$\"[1-53]T$	Acylphosphatase
PS00150	$\"[8-18]T$	ACYLPHOSPHATASE_1
PS51160	$\"[3-92]T$	ACYLPHOSPHATASE_3

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.100	$\"[1-92]T$	G3DSA:3.30.70.100
PTHR10029	$\"[4-92]T$	PTHR10029
SSF54975	$\"[1-92]T$	SSF54975

","BeTs to 5 clades of COG1254COG name: AcylphosphatasesFunctional Class: CThe phylogenetic pattern of COG1254 is a-----v-eb------o----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 8-88 are 45% similar to a (ACYLPHOSPHATASE PROTEOME COMPLETE HYDROLASE) protein domain (PD001884) which is seen in Q9X1Q0_THEMA.Residues 4-90 are 55% similar to a (HYDROGENASE ZINC-FINGER MATURATION) protein domain (PD371993) which is seen in Q9CHW2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 15:28:46 2002","Thu Feb 7 15:54:01 2002","Wed Oct 16 15:28:46 2002","Wed Oct 16 15:28:46 2002","","Thu Feb 7 15:54:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1572 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 15:28:46 2002","","No significant hits to the NCBI PDB database.","SMU.1725","","Residues 1 to 90 (E-value = 5.2e-07) place SMu1572 in the Acylphosphatase family which is described as Acylphosphatase (PF00708)","Thu Feb 7 15:54:01 2002","24380098","","","","","","1","","","SMU.1725","964" "SMu1573","1631478","1632410","933","GTGAAAAAAATTTACAAGCGTCTTTTATTTTCGGGCTTAGCTCTGTCTATGCTTTTTTTCCTATCTGGTTGCGTGCAGATGAAAAATGGAAAACCAACTGGTGAAGGTTGGGTTTACAAATTTTTTGCTGCCCCAATGGGAAGTGTTATCCAATATTTAGCTAATAATCTTGGTCTGGGATTTGGCTTTGCTATTATCATTGTCACAGTTATTGTCCGTCTTCTCATCTTGCCATTAGGTCTTAGTCAAGTACGAAAGATGACTTACCAATCTGAGAAAATGGCTTATCTAAAACCAGTCTTTGATCCTATTCAAGAACGCATGAAGAATGCCAAAACTCAGGAAGAAAAAATGGCTGCTCAAACAGAATTAATGCAGGCGCAGCGTCATTACGGTATGAGCATGTTTGGTGGTTTAGGATGTCTACCGCTGCTGATCCAGATGCCTTTCTTCTCTGCACTTTATATTTCTACCCGTTACACCAAGGGAATCGCCAGTGCTAGTTTCTTAGGTATTAAACTTGGCAGTCCAAATATGATCATCACTGTTATTATTGGAATTCTTTATCTTGTTCAGTCTTGGGTTTCAACGCTAAGTGTTCCAGAAGCACAAAGACAGCAAACAAGAAATATGATGTTTATGATGCCAATTATGATGGTTATGATTTCCATAGGTGCTCCTGCTGGAGGTGCTCTTTACTGGCTAGTCAGTGGTATTTTTGGTCTCATCCAACAATTGATCACAAACCATATCATTAAACCAAAATTGCGGAAGCAAATTGATGAAGAATTTAAGAAAAACCCTCCAAAACCTTTCAAATCAAATGCTCGTAAAGATATCACTCCACAAGCCAATAATGATAAAAAGCTTATAACCTCTAAAAAGCAAAAGTCCAACCGCAATGCAGGTAAACAGCGTCACCATAAGCAATAA","11.10","28.85","34864","MKKIYKRLLFSGLALSMLFFLSGCVQMKNGKPTGEGWVYKFFAAPMGSVIQYLANNLGLGFGFAIIIVTVIVRLLILPLGLSQVRKMTYQSEKMAYLKPVFDPIQERMKNAKTQEEKMAAQTELMQAQRHYGMSMFGGLGCLPLLIQMPFFSALYISTRYTKGIASASFLGIKLGSPNMIITVIIGILYLVQSWVSTLSVPEAQRQQTRNMMFMMPIMMVMISIGAPAGGALYWLVSGIFGLIQQLITNHIIKPKLRKQIDEEFKKNPPKPFKSNARKDITPQANNDKKLITSKKQKSNRNAGKQRHHKQ","1632420","","OxaA-like protein; inner membrane protein","Membrane, Periplasm, Extracellular","Significant hits in gapped BLAST to hypothetical proteins. Residues 1-306 are 505 similar to >gi15674505 as seen in S. pyogenes. Residues 3-306 are 43% similar to >gi15903832 as seen in S. pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1608 (2e-83).","

InterPro
IPR001708
Family

60 kDa inner membrane insertion protein
PR00701	$\"[133-156]T$ $\"[216-239]T$	60KDINNERMP
PTHR12428	$\"[40-257]T$	OXA1
PF02096	$\"[61-253]T$	60KD_IMP

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[95-258]T$	no description

noIPR
unintegrated

unintegrated
PTHR12428:SF11	$\"[40-257]T$	OXAA 1, 2
signalp	$\"[1-30]?$	signal-peptide
tmhmm	$\"[9-27]?$ $\"[57-77]?$ $\"[136-156]?$ $\"[175-195]?$ $\"[216-236]?$	transmembrane_regions

","BeTs to 11 clades of COG0706COG name: Inner membrane proteins, SpoIIIJ familyFunctional Class: SThe phylogenetic pattern of COG0706 is ----yqvceBrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 78-252 are 25% similar to a (TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD409339) which is seen in O66561_AQUAE.Residues 78-247 are 50% similar to a (MEMBRANE COMPLETE PROTEOME INNER) protein domain (PD002157) which is seen in Q9CHZ9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 7 15:56:32 2002","Thu Aug 31 15:50:13 2006","Thu Aug 31 15:50:13 2006","Wed Oct 16 15:28:02 2002","","Wed Jan 16 14:02:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1573 is paralogously related (blast p-value < 1e-3) to SMu0303, a possible inner membrane protein.","Thu Feb 7 15:56:32 2002","","No significant hits to the NCBI PDB database.","SMU.1727","","Residues 61 to 253 (E-value = 1.4e-38) place SMu1573 in the 60KD_IMP family which is described as 60Kd inner membrane protein (PF02096)","Wed Jan 16 14:02:02 2002","24380099","","","","","","1","","","SMU.1727","596" "SMu1574","1633307","1632825","483","ATGTCAGAAAAAACTTATCCAATGACTCTTGCAGAAAAAGAACAATTAGAACAAGAACTTGAAGAGTTAAAATTAGTTCGTCGTCCAGAAGTGATTGAACGTATTAAAATAGCACGTTCTTATGGTGATTTATCAGAAAATAGTGAATATGAAGCGGCAAAAGATGAACAAGCTTTTGTTGAAGGACAAATTTCAAGTATTGAAACTAAAATTCGTTATGCTGAAATTGTTGACAGTGATGCTGTTGCTAAAAATGAGGTCGCTATTGGTAAAACAGTTATTGTTCGTGAAGTAGGAACAAACGATGAAGATACTTATTCTATTGTTGGTGCCGCCGGAGCTGATGTTTTTGCTGGAAAAATTTCTAATGAGAGCCCAATTGCTCAAGCACTTATCGGTAAGAAAACAGGTGATAAAGTAATGATTGAATCACCAGCGGGAAGTTATCAAGTCGAAATTGTTAAAGTGAAAAAGACAAAATAA","4.60","-7.98","17570","MSEKTYPMTLAEKEQLEQELEELKLVRRPEVIERIKIARSYGDLSENSEYEAAKDEQAFVEGQISSIETKIRYAEIVDSDAVAKNEVAIGKTVIVREVGTNDEDTYSIVGAAGADVFAGKISNESPIAQALIGKKTGDKVMIESPAGSYQVEIVKVKKTK","1632841","","transcription elongation factor GreA","Cytoplasm","Similarities in gapped BLAST to transcription elongation factor GreA sequences. Residues 1-159 are 77% similar to gi|15674504 from S.pyogenes and 72% similar to gi|15903412 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1612 (5e-65).","

InterPro
IPR001437
Domain

Transcription elongation factor, GreA/GreB region, prokaryotic
PD004918	$\"[102-156]T$	GreA_GreB
G3DSA:1.10.287.180	$\"[3-77]T$	GreA_GreB_reg
PF01272	$\"[82-158]T$	GreA_GreB
PF03449	$\"[3-76]T$	GreA_GreB_N
PS00829	$\"[19-50]T$	GREAB_1
PS00830	$\"[122-138]T$	GREAB_2
SSF46557	$\"[4-81]T$	GreA_GreB

InterPro
IPR006359
Domain

Prokaryotic transcription elongation factor GreA
TIGR01462	$\"[7-157]T$	greA

InterPro
IPR012243
Family

Prokaryotic transcription elongation factor GreA, GreB
PIRSF006092	$\"[3-159]T$	GreA

noIPR
unintegrated

unintegrated
SSF54534	$\"[81-159]T$	SSF54534

","BeTs to 10 clades of COG0782COG name: Transcription elongation factorFunctional Class: KThe phylogenetic pattern of COG0782 is ------v-EbRHujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001437 (Prokaryotic transcription elongation factor GreA/GreB) with a combined E-value of 2.5e-45. IPB001437A 19-68 IPB001437B 106-138","Residues 67-157 are 34% similar to a (KINASE PROTEOME NUCLEOSIDE REGULATOR) protein domain (PD083674) which is seen in Q9RV68_DEIRA.Residues 71-140 are 67% similar to a (FACTOR TRANSCRIPTION ELONGATION COIL) protein domain (PD344060) which is seen in GREA_LACLA.Residues 26-65 are 87% similar to a (FACTOR TRANSCRIPTION ELONGATION COIL) protein domain (PD004918) which is seen in GREA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 11:13:23 2002","Wed Feb 27 11:13:23 2002","Wed Oct 16 15:27:03 2002","Wed Oct 16 15:27:03 2002","Wed Feb 27 11:12:45 2002","Wed Feb 27 11:12:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1574 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 11:13:23 2002","Wed Feb 27 11:12:45 2002","pdb|1GRJ| Grea Transcript Cleavage Factor From Escherichia Coli 118 5e-028","SMU.1728c","","Residues 3 to 76 (E-value = 3e-24) place SMu1574 in the GreA_GreB_N family which is described as Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain (PF03449)Residues 82 to 158 (E-value = 2.2e-15) place SMu1574 in the GreA_GreB family which is described as Prokaryotic transcription elongation factor, GreA/GreB, C-terminal domain (PF01272)","Wed Feb 27 11:12:45 2002","","","","Artsimovitch I, Svetlov V, Anthony L, Burgess RR, Landick R.RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro.J Bacteriol. 2000 Nov;182(21):6027-35.PMID: 11029421 ","","Wed Feb 27 11:20:41 2002","1","","","SMU.1728c","713" "SMu1575","1635287","1633443","1845","ATGAAAAAGGCTAAGCAATCACGTAAAAATCGTGATATTAGTCAAGTGAAGAAGGGAAATGTTGCTAAGGATCACCAAAAGTATTCTGATTCAGCAGTGCAAAAACAGGATAAAGAAGAAACACGAACTGTTATGCCGATTCCTGAAGGAAATATTACAGATAAAGATGTTGATAATGTTCTGGCTAATTTAGATGAAATTTTTGCGCCTGGGCAACTGAATCATTCTGATCAAATTAATGAGAAGGAAAATTCCCAACAAATTACAGGGAAACAATCTTCTTCCTTAAAGACTGGTTCTGCTACTCAAGAAACTGAAACTTTTCAATCTAAGGAAAGTTTGACACTTCCTAATAAAAAAACATCAGAAAACAAAGTTTCTGATGTTTTGGAAGTTAAAGTAAAAAAAACGAACAATTGGGTTGATGATGGTGAGGCAGAAAATTGGCAATTACCTGATTTGACTGAAAAATTGACAAATAATAATGATGAAGAAACAAAAGAATTGCCTTTATCCAGTTTGGCTGAAAAGACCAACTCAGAATCGGAAATGAAACATAGTGTCAAAGAAACTGAAGAACTCTTAAAACAAGAGAAAAAGCTATCTTCAAAATATGATAAAACAAAATCTCAGACAAAAGCTAGTTCCAAGGAAAAGGATGTGACAGCTAATTTGAACCAAAAAAGACAGCAGCATTATAAAAAAACAAATAGACTCGCTAAAAAGATTTCAACTGTCTTGATAACTTTTATTTTAATTTTATTGTTAGGAACAGGACTTTTTGGTTATTATTATGTTTCGAGTGCTATAAAGCCATTGGATGCTCATTCAACTAAGTATATTCAAGTAGAGATTCCTAGTGGTTCTGGTAATCGAATGATTGGTAAAATACTTGAAAAAGCTGGTGTAATCAAGAATGCCACTGTTTTTAATTTTTACACCAAATTCCGTAATTACAGTAATTTACAAAGTGGCTACTATAATTTACAAAAAAGCATGTCTTTAGATGATATTGCTAAAACTTTGAAAAATGGGGGTACGACAACGCCTCAAGCTCCAGTTTTAGGAAAGGTGGTCATTCCAGAAGGCTATACCATTAAGCAAATTTCCAAAGCTATCACTAGCAATGCTAATACCAAAAAAAAGACGGATAAAACCCCTTTTACAGCTAAAGAATTTTTAAAAACGGTTAAGGATAAAGCATTTATTGAGAAAATGGTCAAGAAGTACCCAAGACTTTTGGGAAGCTTACCTGATGCTTCTAAGGTGACTTATCAGCTTGAAGGTTATCTTTTCCCAGCCACATACAGTTATGGGGAAAAGACCAGTATTGAGGATTTAATTGATAATATGTTAGCTGCTATGGATACTAATATGCAAAGTTATTATGATACGATTGAATCTCAAGGAAAGACAGTTAATGACATCTTAACGCTTGCTTCTCTTGTCGAAAAAGAAGGTGCAACAGATGATGATCGAAAGAAAATTGCTGGTATTTTCTACAATCGTATAAATCAGGATATGCCATTGCAGTCTAATATTGCTATCCTTTATGCTATGGGAAAACTTGGTGAGAAAACCAGTTTAAAAGAAGATGCAACTATTAATACTAAAATTGATTCTCCTTACAATGTTTATACCAATAAAGGACTTATGCCTGGGGCAGTAGATAATCCTAGTTTGTCAGCCATCAAAGCAGCAGTAGAACCAGAGTCAACAGATGATCTTTATTTTGTAGCCGATGTTACAACAGGTGAAGTTCATTATGCTAAAACTTATGAGGAACACTCTGCCAATGTTGAGAAGTATGTTAACAAAAAGGTAGCATCAAGCAGTGATTCGTAA","9.60","8.75","68535","MKKAKQSRKNRDISQVKKGNVAKDHQKYSDSAVQKQDKEETRTVMPIPEGNITDKDVDNVLANLDEIFAPGQLNHSDQINEKENSQQITGKQSSSLKTGSATQETETFQSKESLTLPNKKTSENKVSDVLEVKVKKTNNWVDDGEAENWQLPDLTEKLTNNNDEETKELPLSSLAEKTNSESEMKHSVKETEELLKQEKKLSSKYDKTKSQTKASSKEKDVTANLNQKRQQHYKKTNRLAKKISTVLITFILILLLGTGLFGYYYVSSAIKPLDAHSTKYIQVEIPSGSGNRMIGKILEKAGVIKNATVFNFYTKFRNYSNLQSGYYNLQKSMSLDDIAKTLKNGGTTTPQAPVLGKVVIPEGYTIKQISKAITSNANTKKKTDKTPFTAKEFLKTVKDKAFIEKMVKKYPRLLGSLPDASKVTYQLEGYLFPATYSYGEKTSIEDLIDNMLAAMDTNMQSYYDTIESQGKTVNDILTLASLVEKEGATDDDRKKIAGIFYNRINQDMPLQSNIAILYAMGKLGEKTSLKEDATINTKIDSPYNVYTNKGLMPGAVDNPSLSAIKAAVEPESTDDLYFVADVTTGEVHYAKTYEEHSANVEKYVNKKVASSSDS","1633459","","aminodeoxychorismate lyase-like protein (fragment)","Extracellular","Matches in gapped BLAST to fragments of aminodeoxychorismate lyase-like protein. Residues 213-608 are 58% similar to residues 123-523 of gi15674503 from S.pyogenes. Residues 109-610 are 43% similar to residues 77-550 of gi15672617 (YgcC) from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1613 (1e-134).","

InterPro
IPR003770
Family

Aminodeoxychorismate lyase
PF02618	$\"[281-606]T$	ADC_lyase
TIGR00247	$\"[236-610]T$	ADC_lyase

","BeTs to 8 clades of COG1559COG name: Uncharacterized BCR, YceG familyFunctional Class: SThe phylogenetic pattern of COG1559 is -----q--ebrhuj--ol--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 428-603 are 59% similar to a (PROTEOME COMPLETE LYASE MEMBRANE) protein domain (PD009996) which is seen in Q9CHT3_LACLA.Residues 268-410 are 51% similar to a (PROTEOME COMPLETE YGCC YRRL) protein domain (PD132462) which is seen in Q9CHT3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 11:25:18 2002","Wed Feb 27 11:22:11 2002","Thu Sep 14 17:04:42 2006","Wed Oct 16 15:24:34 2002","","Wed Feb 27 11:22:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1575 is paralogously related (blast p-value < 1e-3) to SMu1947, a conserved hypothetical, and to SMu0500, a predicted dell divisiion protein.","Wed Feb 27 11:33:19 2002","","No significant hits to the NCBI PDB database.","SMU.1729c","","Residues 281 to 606 (E-value = 8.3e-139) place SMu1575 in the ADC_lyase family which is described as Aminodeoxychorismate lyase (PF02618)","Wed Feb 27 11:22:11 2002","24380101","","","","","","1","","","SMU.1729c","446" "SMu1576","1635952","1635461","492","ATGCTTATTCGACAAGTGACAATGGAAGATTTAGAAGATATCATCCGAATCGAAAATGATAATTTTTCAGCTGAAGAAGCAGCAACATCTCAAGCTTTAAAGGAGCGTATTGAAGTCATAGCAGATACTTTTTTGGTTGCTGAGCAAGATGGTCAGATAGCTGGCTATGTTGAAGGGCCTGTTATCAACAGTCGTTACTTGACTGATGATTTATTCCATAAGGTTAAACCCAATCAAGAAAAGTCGGGTTATATTGCTGTTACAAGTCTTTCGGTTGATAAAGCATTTCAAAAACAAGGCGTTGGTACAACTTTACTAGCTGCTCTTAAAGATTTAACTGTGGCTCAAAACCGGCTGGGAATTCATTTAACCTGTCATGATTATTTGATTTCTTACTATGAGATGAATGGCTTTAGTAATGAAGGATTGTCAGAATCAACCCATGGAGGAACCGTTTGGTATAATATGATTTGGGAAAATCCTAAGATTTAG","4.50","-10.08","18260","MLIRQVTMEDLEDIIRIENDNFSAEEAATSQALKERIEVIADTFLVAEQDGQIAGYVEGPVINSRYLTDDLFHKVKPNQEKSGYIAVTSLSVDKAFQKQGVGTTLLAALKDLTVAQNRLGIHLTCHDYLISYYEMNGFSNEGLSESTHGGTVWYNMIWENPKI","1635477","","arylalkylamine n-acetyltransferase","Cytoplasm","Similarities in gapped BLAST to arylalkylamine n-acetyltranssferases and to hypothetical proteins. Residues 1-159 are 64% similar to gi15674502 from S.pyogenes. Residues 1-147 are 49% similar to gi15925651 from S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1614 (3e-54).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[45-139]T$	Acetyltransf_1
PS51186	$\"[1-159]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[3-160]T$	G3DSA:3.40.630.30
PTHR23091	$\"[6-123]T$	PTHR23091
PTHR23091:SF1	$\"[6-123]T$	PTHR23091:SF1
SSF55729	$\"[1-159]T$	SSF55729

InterPro
IPR000713
Domain

Cytoplasmic peptidoglycan synthetase, N-terminal
PF01225	$\"[13-113]T$	Mur_ligase

InterPro
IPR004101
Domain

Cytoplasmic peptidoglycan synthetases, C-terminal
PF02875	$\"[306-393]T$	Mur_ligase_C

InterPro
IPR005758
Family

UDP-N-acetylmuramate--alanine ligase
TIGR01082	$\"[13-441]T$	murC

InterPro
IPR012237
Family

UDP-N-acetylmuramate-alanine ligase
PIRSF001562	$\"[12-441]T$	UDP-NAcM_Alig

InterPro
IPR013221
Domain

Mur ligase, middle region
PF08245	$\"[115-286]T$	Mur_ligase_M

noIPR
unintegrated

unintegrated
PTHR23135	$\"[117-452]T$	PTHR23135
PTHR23135:SF5	$\"[117-452]T$	PTHR23135:SF5
SSF51984	$\"[11-100]T$	SSF51984
SSF53244	$\"[305-444]T$	SSF53244
SSF53623	$\"[100-304]T$	SSF53623

","BeTs to 11 clades of COG0773COG name: UDP-N-acetylmuramate-alanine ligaseFunctional Class: MThe phylogenetic pattern of COG0773 is -----qvcEbrHuj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 239-293 are 43% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN) protein domain (PD039273) which is seen in MURC_LACLA.Residues 381-445 are 40% similar to a (LIGASE PROTEOME COMPLETE) protein domain (PD386550) which is seen in Q9K7W1_BACHD.Residues 12-174 are 75% similar to a (LIGASE CELL SYNTHETASE PEPTIDOGLYCAN SYNTHESIS) protein domain (PD001083) which is seen in MURC_LACLA.Residues 175-233 are 54% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS ENZYME) protein domain (PD212530) which is seen in MURC_BACSU.Residues 175-234 are 71% similar to a (LIGASE CELL ATP-BINDING SYNTHESIS) protein domain (PD336761) which is seen in MURC_LACLA.Residues 300-447 are 72% similar to a (LIGASE SYNTHETASE CELL PEPTIDOGLYCAN SYNTHESIS) protein domain (PD001216) which is seen in MURC_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 15 09:55:55 2006","Tue Aug 15 09:55:55 2006","Tue Aug 15 09:55:55 2006","Thu Apr 4 09:13:14 2002","","Wed Feb 27 11:34:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1577 is paralogously related (blast p-value < 1e-3) to SMu0498, a predicted murD protein, and to SMu0704, a conserved hypothetical protein.","Wed Feb 27 11:41:21 2002","","No significant hits to the NCBI PDB database.","SMU.1731c","","Residues 44 to 297 (E-value = 1.4e-35) place SMu1577 in the Mur_ligase family which is described as Mur ligase family, catalytic domain (PF01225)Residues 306 to 395 (E-value = 2.9e-22) place SMu1577 in the Mur_ligase_C family which is described as Mur ligase family, glutamate ligase domain (PF02875)","Tue Aug 15 09:55:55 2006","","","","Reck F, Marmor S, Fisher S, Wuonola MA.Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.Bioorg Med Chem Lett. 2001 Jun 4;11(11):1451-4.PMID: 11378375 ","","Wed Feb 27 11:39:57 2002","1","","","SMU.1731c","164" "SMu1578","1637943","1637353","591","ATGAGTCGTGAAAGAAAGTTTCCTTTAGTCGATGATAATGACGTTGTGGTTGCAGTTCCTAAAACAATGCGTCTATATGAAAACGAAGACTTGATCACAAATATCCACGGTCCTTACGAAGATAAGGTTTATAACGACGTAACTCAAGATTATCAGTTTATACCTGATAATCCTAATCCTCAGAAAGTAGCTTCAGACCGCCTTGTGACACAAAAGGCAGGAAAAACTTATGCCGAATTAGCGCGTGAAGAAGCCAGATGGGATCTAAAAAAGAAAAGACAATCCTTAATTACAAATGATTACCCTAAATCGGTTTCTAGAACAAGTACCAAAAAATCTGAAAAAGCAACTAAGGCTCCTAAGAATGAGTTGGGACGTTTTTCCGATCATCTCCATCAAGATACTTATATCTTGGCTGAGCTTCCCAAAAATTATTCAGAGCCAAAAAATCCTTCTAGAAAAGAGAACAAAAAAAATAACTATGATTTCTTGAAAACGAGTCAAATTTATAATCAAAAAGAAAAGCAAGAATATCAAGATCGTCATGTGGCCCAAGAACTAAATTTGGAACGCTTTGAAGATGTTAACTAG","9.40","2.97","23097","MSRERKFPLVDDNDVVVAVPKTMRLYENEDLITNIHGPYEDKVYNDVTQDYQFIPDNPNPQKVASDRLVTQKAGKTYAELAREEARWDLKKKRQSLITNDYPKSVSRTSTKKSEKATKAPKNELGRFSDHLHQDTYILAELPKNYSEPKNPSRKENKKNNYDFLKTSQIYNQKEKQEYQDRHVAQELNLERFEDVN","1637369","","conserved hypothetical protein","Extracellular","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 4-195 are 44% similar to gi|15674500 from S.pyogenes. Residues 3-194 are 39% similar to gi|15903417 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1616 (5e-31).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:41:16 2002","Wed Feb 27 11:44:53 2002","Tue Oct 8 17:41:16 2002","Wed Feb 27 11:44:53 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1578 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:41:16 2002","","No significant hits to the NCBI PDB database.","SMU.1732c","","No significant hits to the Pfam 11.0 database","Wed Feb 27 11:44:53 2002","24380104","","","","","","1","","","SMU.1732c","967" "SMu1579","1641097","1638005","3093","ATGAGTAAATTGATTCCTGGGCGTGTCCGCAATGAGGGCATCCACTTTTATGAAAAAGATTTGGTCTCTATTCTAGAAGAAAAAGATAACTCACTATTAGTGCAGGTTGCTGATTATAAGATCCAATTTTCTCTTGAAGATGATTTAGTTTCTTGTCCTTGTAGCATGTTTCAAAAAAGAGGTTATTGTTCTCATTTAGCTGCAGTTGAACATTATTTGAAAAATCACCCCAAAGGTAAAAATTTGGCTGATAATTTGCTAGCTGATGAACAAAAACTTGAAGAAAGAAAAGAGAAAACTTCCCTTGGCAGCCTCTTCCTTGATGGTTTAAACATGAATGAAGATGATGATGTTAAATATCGTTTATCTGCTCAAGGCAGTCAAAGTCCTTTTTCTTCTGATTTTTGGTGGACTTTGAAAATCAATCGTTTACCCGATGAACGTTCTTATGTTATTCGTGATATAAAAGCTTTTTTATTATTGGTGAAGAAGGAATCTTATTATCAGATAGGAAAAAATTACTATGAACCGCTTTCCCTGCTGCAATTTGATACTGCTAGTCAGGAGTTAATTGAGTTTTTATGGCGCATTCTGCCAGATTCAAATCAAGTAGACACAGATTTTATTATGCCTAATCATGCCCGTAATCTAACTTTTACAAGCGGTTTTTTTGAAGAAGGAGTGACACTTTTAAACCAACTCTATGATTTCTCTTTTGAAGGAGAGCATCAGGATTATCATACTATTAATTTTGCAGAGTTGGATAGTTCCAATCAATTTTATCATTTTAAGATAGTTGTTCATCGTCAATCAATTGAGTTGATTATCAAAGAAAAAACAGCAACTTTTTTCTTTGATAATCACTATTTACTCTATCATAATACCTTTTATCATCTGAACAATAAGCAAAGAAAATTGGTAACTGCAATTAGAAGTCTGCCTTTAGAAAAAGACTTGGCAAAACATATTTATTTTGATTTTGAAGATCAGGCTAAATTAGCAGCAAGCCTTTTAGACTTTAAGACTCTTGGTGAAGTTGAAGCACCAGCAAGTTTTGATATTCGTGATTTTGATGTAGTATTTACGTTTAGTCTATTAGCTAATCGCGAAATTCTGTTGGAATTGACTTTTGATTATGGACAGATAAAAGTGTCCAATGTCAAGGGAAAAGAGGCTCTTCCTTTTGCTAGCAATTTTAAAAAAGAAAAGAAGATTGCTAATCTTTTGAAACAGTATGGCTTTTCACAAGGTTTTAGGTCTTATCATCCCCCTTTATTAGATGAAGAGCTTTATAACTTTTTTACAGAGACCTTAAGTCATTTTGAACGGTTTGGTAAGGTATTGCTTTCACCTTCTATTGAAGCGTTACGTTATCTTGAAAAACCTCAAATTGATATTAAGACCGAACAGGGATTGTTGGATATTTCTTTTGATTTTTCAACAATTTTTGAAAATGATATTGATAATGCCTTAACAGCACTTTTTGAAAATCATTCCTATTTTGTTAGTCAATCAGGGAAATTAATTATCTTTGATGAAGAAACCCAAAAGGTTAGTCAAGCGTTGCAAAATCTGCGTGCACAAAAACCTCATAATGGACATTTGCAGATTAATAAATTCGCAGCTTATCAAGTCTCTGAAACCCTTCAGAATATGGATAACGTTCACTTTTCAGAGGACTTCAGTCAATTAGTCAAAGATTTACGGCATCCAGAAGATTTTTCTTTACCAGAATTTGAAGTTAATGCCAGTTTACGTGAGTATCAGGTCAGAGGTATCAAATGGATGTCTATGCTTGATAAGTACGGTTTTGGTGGTATTTTGGCTGATGATATGGGTTTGGGGAAAACTTTGCAGACCCTTTCTTTTTTAACAAGCCGCTTAGATAAAGATTCTAAAGTCTTGATTTTATCACCTTCGAGTTTGATTTATAATTGGCAAGATGAATGTCAAAAGTTCACCCCTCAGTTAGATGTTGCCGTCTCATACGGTTTAAAGGCGGTAAGAGATGAGATTATTGCAGAAAATCATCAAATTACAATTACTAGTTATGCATCATTCAGGCAAGATTTTAATCTCTATAATCAACTGAACTTTGACTATTTAATCTTAGATGAAGCTCAAGTTATGAAAAATACTCAGACTAAAATAGCGCAAAGTTTGCGTGCTTTTGATGTCAAAAATTGTTTTGCCTTATCAGGTACACCTATTGAAAATAAACTTTTGGAAATTTGGTCCATTTTTCAAATTGTCTTGCCTGGACTTTTACCCACTAAAAAAGAATTTCTTAAAATGGAACCACAAAGTGTGGCTCGCTATATCAGTCCTTTTATCATGCGCCGCCGCAAAGAGGATGTCCTGCCCGAATTGCCAGATTTGATTGAAATTAATTATCATAATGAATTGATAGATAGTCAAAAGGCGATTTACTTGGCACAATTGCGTCAGATGCAAGACGGCATTCGTCATTCTTCTGATTCTGAAATTAATCGGCAAAAAATTGAAATTCTTTCAGGTATCACACGTCTACGTCAAATTTGCGATACGCCAAAACTTTTTATGAATTATGATGATGACAGTGGGAAATTGGCTAGTTTACGTGAGCTTCTACTACAGATTAAAGAAAATGGGCATCGAGCGCTTATCTTCTCTCAGTTTCGTGATATGCTTGATTTAGCAGAAAAAGAAATAGAGGCCTTGGGTTTAACGAGTTATAAGATGACGGGTTCAACTCCTGCTAATGAGCGTCAAGAAATGACGCATGCTTTTAATAATGGCAGTAAGGATACTTTTTTAATTTCCTTGAAAGCTGGTGGTGTCGGTCTTAACCTGACAGGAGCAGATACGGTCGTTTTGATTGATCTATGGTGGAATCCAGCCATTGAGATGCAGGCTATTAGCCGCGCTCATCGTATTGGTCAAAAAGAGAATGTTGAGGTTTACCGTATGATTACTCGAGGAACAATAGAAGAGAAAATTTTAGAACTCCAAGAAAGCAAGAAGAATTTAGTAACAACTGTGTTAGATGGAAATGAGAGTCGTGCCAGTATGAGTATTGAAGAAATAAAAGAAATTTTAGGAATTTCTTCATGA","5.30","-26.88","118909","MSKLIPGRVRNEGIHFYEKDLVSILEEKDNSLLVQVADYKIQFSLEDDLVSCPCSMFQKRGYCSHLAAVEHYLKNHPKGKNLADNLLADEQKLEERKEKTSLGSLFLDGLNMNEDDDVKYRLSAQGSQSPFSSDFWWTLKINRLPDERSYVIRDIKAFLLLVKKESYYQIGKNYYEPLSLLQFDTASQELIEFLWRILPDSNQVDTDFIMPNHARNLTFTSGFFEEGVTLLNQLYDFSFEGEHQDYHTINFAELDSSNQFYHFKIVVHRQSIELIIKEKTATFFFDNHYLLYHNTFYHLNNKQRKLVTAIRSLPLEKDLAKHIYFDFEDQAKLAASLLDFKTLGEVEAPASFDIRDFDVVFTFSLLANREILLELTFDYGQIKVSNVKGKEALPFASNFKKEKKIANLLKQYGFSQGFRSYHPPLLDEELYNFFTETLSHFERFGKVLLSPSIEALRYLEKPQIDIKTEQGLLDISFDFSTIFENDIDNALTALFENHSYFVSQSGKLIIFDEETQKVSQALQNLRAQKPHNGHLQINKFAAYQVSETLQNMDNVHFSEDFSQLVKDLRHPEDFSLPEFEVNASLREYQVRGIKWMSMLDKYGFGGILADDMGLGKTLQTLSFLTSRLDKDSKVLILSPSSLIYNWQDECQKFTPQLDVAVSYGLKAVRDEIIAENHQITITSYASFRQDFNLYNQLNFDYLILDEAQVMKNTQTKIAQSLRAFDVKNCFALSGTPIENKLLEIWSIFQIVLPGLLPTKKEFLKMEPQSVARYISPFIMRRRKEDVLPELPDLIEINYHNELIDSQKAIYLAQLRQMQDGIRHSSDSEINRQKIEILSGITRLRQICDTPKLFMNYDDDSGKLASLRELLLQIKENGHRALIFSQFRDMLDLAEKEIEALGLTSYKMTGSTPANERQEMTHAFNNGSKDTFLISLKAGGVGLNLTGADTVVLIDLWWNPAIEMQAISRAHRIGQKENVEVYRMITRGTIEEKILELQESKKNLVTTVLDGNESRASMSIEEIKEILGISS","1638021","","SNF helicase","Cytoplasm, Extracellular","Similarities in gapped BLAST to SNF helicases. Residues 1-1030 are 67% similar to gi15674499 from S.pyogenes and 51% similar to gi15901369 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1618 (0.0).","

InterPro
IPR000330
Domain

SNF2-related
PF00176	$\"[588-762]T$ $\"[773-853]T$	SNF2_N

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[896-973]T$	Helicase_C
SM00490	$\"[891-973]T$	HELICc
PS51194	$\"[865-1023]T$	HELICASE_CTER

InterPro
IPR007527
Domain

Zinc finger, SWIM-type
PF04434	$\"[39-74]T$	SWIM
PS50966	$\"[39-74]T$	ZF_SWIM

InterPro
IPR013663
Domain

SNF2 helicase associated, bacterial
PF08455	$\"[214-577]T$	SNF2_assoc

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[581-762]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[597-754]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[846-1013]T$	G3DSA:3.40.50.300
PTHR10799	$\"[8-59]T$ $\"[568-1028]T$	PTHR10799
PTHR10799:SF72	$\"[8-59]T$ $\"[568-1028]T$	PTHR10799:SF72
SSF52540	$\"[353-753]T$ $\"[846-1029]T$	SSF52540

","BeTs to 10 clades of COG0553COG name: Superfamily II DNA/RNA helicases, SNF2 familyFunctional Class: K,LThe phylogenetic pattern of COG0553 is a--kY-vceBrh--gp--IN-Number of proteins in this genome belonging to this COG is 1","***** IPB000330 (SNF2 related domain) with a combined E-value of 1.4e-75. IPB000330A 585-599 IPB000330B 607-621 IPB000330C 633-646 IPB000330D 729-753 IPB000330E 790-810 IPB000330F 904-924 IPB000330G 931-982","Residues 777-933 are 26% similar to a (ATP-BINDING HELICASE A548L) protein domain (PD210286) which is seen in O41030_CHVP1.Residues 933-1028 are 65% similar to a (HELICASE ATP-BINDING NUCLEAR DNA-BINDING REPAIR COMPLETE) protein domain (PD039514) which is seen in Q9CE08_LACLA.Residues 770-812 are 62% similar to a (HELICASE ATP-BINDING FAMILY PROTEOME) protein domain (PD126818) which is seen in Q9CE08_LACLA.Residues 607-661 are 60% similar to a (HELICASE ATP-BINDING COMPLETE PROTEOME) protein domain (PD364536) which is seen in Q9CE08_LACLA.Residues 817-863 are 54% similar to a (HELICASE PROTEOME ATP-BINDING COMPLETE) protein domain (PD411301) which is seen in Q9CE08_LACLA.Residues 1-296 are 31% similar to a (HELICASE PROTEOME COMPLETE FAMILY) protein domain (PD401444) which is seen in Q9CE08_LACLA.Residues 297-606 are 38% similar to a (HELICASE PROTEOME ATP-BINDING COMPLETE) protein domain (PD416170) which is seen in Q9CE08_LACLA.Residues 607-664 are 55% similar to a (HELICASE ATP-BINDING NUCLEAR DNA-BINDING REPAIR) protein domain (PD334662) which is seen in O84714_CHLTR.Residues 866-924 are 55% similar to a (HELICASE ATP-BINDING NUCLEAR DNA-BINDING REPAIR) protein domain (PD336785) which is seen in Q9CE08_LACLA.Residues 669-747 are 54% similar to a (HELICASE ATP-BINDING NUCLEAR DNA-BINDING) protein domain (PD000441) which is seen in Q9CE08_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 12:21:45 2002","Wed Feb 27 12:20:56 2002","Tue Aug 15 10:02:22 2006","Wed Oct 16 15:17:44 2002","Wed Feb 27 12:20:56 2002","Wed Feb 27 12:20:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1579 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 12:21:45 2002","","No significant hits to the NCBI PDB database.","SMU.1733c","","Residues 39 to 74 (E-value = 1.6e-05) place SMu1579 in the SWIM family which is described as SWIM zinc finger (PF04434)Residues 588 to 853 (E-value = 2.2e-57) place SMu1579 in the SNF2_N family which is described as SNF2 family N-terminal domain (PF00176)Residues 896 to 973 (E-value = 2.7e-24) place SMu1579 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)","Tue Aug 15 10:02:22 2006","24380105","","","","","","1","","","SMU.1733c","165" "SMu1580","1641983","1641213","771","ATGAGTGATGTATCAAGAATACTCAAGGAAGCTCGTAGTCAATCGCGTTTGACAACTTTGGATTATGCAGAGCAAATTTTTGATGATTTTATGGAACTACATGGAGATCGTCATTTTGCAGATGATGGCGCTATTGTTGGAGGTATTGGCCTTTTGGATGGTCAAGCAGTAACCGTCATTGGCGTTCAAAAAGGAAAGAATTTACAGGATAATCTTAATCGTAATTTCGGCCAACCCAATCCAGAGGGTTATCGGAAAGCTTTGCGACTGATGAAACAAGCGGAAAAATTTAAAAGACCGGTTGTCACTTTTATCAACACAGCAGGAGCTTATCCGGGTATTGGAGCTGAAGAGCGCGGTCAAGGAGAAGCGATTGCCAGAAATTTGCTAGAAATGAGTGATCTTAAAGTTCCGATTATTGCTATTATCATTGGTGAAGGAGGCTCAGGTGGAGCACTAGCTTTAGCGGTTGCTGATAAGGTTTGGATGCTTGAGCATACGATGTATGCAGTACTTAGTCCAGAAGGTTTTGCTTCTATTCTCTGGAAGGACGGCAGCCGCTCAATTGAAGCCGCTGAACTAATGAAAATTACAGCTGGTGAATTGCTCAAAATGGAGGTTGTTGACAAGGTAATTCCTGAACATGGCTATTTTTCAAGTGAAATTATTCAAATGCTCAAGACCAATTTAATTGAAGAATTAAAGAATTTGGATCAATATCCTTTGAACGATTTACTTGAAAAACGTTACCAACGTTTTAGAAAGTATTAA","5.50","-4.02","28473","MSDVSRILKEARSQSRLTTLDYAEQIFDDFMELHGDRHFADDGAIVGGIGLLDGQAVTVIGVQKGKNLQDNLNRNFGQPNPEGYRKALRLMKQAEKFKRPVVTFINTAGAYPGIGAEERGQGEAIARNLLEMSDLKVPIIAIIIGEGGSGGALALAVADKVWMLEHTMYAVLSPEGFASILWKDGSRSIEAAELMKITAGELLKMEVVDKVIPEHGYFSSEIIQMLKTNLIEELKNLDQYPLNDLLEKRYQRFRKY","1641229","For other 'acc' genes see SMu1581 (accD) and SMu1582 (accC).For the beta subunit see SMu1581 (accD).","acetyl-CoA carboxylase alpha subunit","Cytoplasm, Membrane","Similarities in gapped BLAST to accA sequences. Residues 1-256 are 75% similar to gi|15675592 from S.pyogenes. Residues 3-256 are 58% similar to gi|15902431 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0354 (1e-108).","

InterPro
IPR001095
Family

Acetyl-CoA carboxylase, alpha subunit
PR01069	$\"[35-46]T$ $\"[60-78]T$ $\"[81-97]T$ $\"[100-113]T$ $\"[116-129]T$ $\"[144-153]T$	ACCCTRFRASEA
PTHR22855:SF3	$\"[11-255]T$	Ac-CoA_carboxylA
PF03255	$\"[2-95]T$	ACCA
TIGR00513	$\"[1-256]T$	accA

InterPro
IPR011763
Domain

Acetyl-coenzyme A carboxyltransferase, C-terminal
PS50989	$\"[1-256]T$	COA_CT_CTER

noIPR
unintegrated

unintegrated
G3DSA:3.90.226.10	$\"[20-212]T$	G3DSA:3.90.226.10
PTHR22855	$\"[11-255]T$	PTHR22855
SSF52096	$\"[11-256]T$	SSF52096

","BeTs to 11 clades of COG0825COG name: Acetyl-CoA carboxylase alpha subunitFunctional Class: IThe phylogenetic pattern of COG0825 is a--kyqvceBRhuj----inxNumber of proteins in this genome belonging to this COG is 1","***** PR01069 (Acetyl-CoA carboxylase carboxyl transferase alpha subunit signature) with a combined E-value of 1.1e-54. PR01069A 35-46 PR01069B 60-78 PR01069C 81-97 PR01069D 100-113 PR01069E 116-129 PR01069F 144-153","Residues 3-256 are 68% similar to a (TRANSFERASE ALPHA SUBUNIT CARBOXYLASE) protein domain (PD004951) which is seen in Q9FBB7_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 15:16:25 2002","Wed Feb 27 12:22:52 2002","Wed Oct 16 15:16:25 2002","Thu Apr 11 09:46:47 2002","Wed Feb 27 12:22:52 2002","Wed Feb 27 12:22:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1580 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 12:26:22 2002","","No significant hits to the NCBI PDB database.","SMU.1734c","","Residues 2 to 95 (E-value = 2e-25) place SMu1580 in the ACCA family which is described as Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit (PF03255)","Wed Feb 27 12:22:52 2002","","","","Marini PE, Perez CA, de Mendoza D.Growth-rate regulation of the Bacillus subtilis accBC operon encoding subunits of acetyl-CoA carboxylase, the first enzyme of fatty acid synthesis.Arch Microbiol. 2001 Mar;175(3):234-7.PMID: 11357516","","Wed Feb 27 12:37:22 2002","1","","","SMU.1734c","268" "SMu1581","1642846","1641980","867","ATGGCTTTATTTGAAAGAAAAAACAAGTATATTCGCATAAATCCTCAACGCTCGATGAAAAAGACAAAGGAGCGGGAGACTCCTGAAGTTCCGGATGAATTATTTGCTAAATGTCCTGCTTGTAAACACATGATCTATCAAAAAGATTTGGGTCTAGAAAAAATTTGCCCTAAATGTTTTTATAATTTTCGTATTTCAGCTAAAGAACGATTAGCTATTACAGTTGATGGAGACTCTTTTCAAGAAATGTTTACAGGCATTAAAAGCAAGGATCCGCTTAATTTTCCTGCTTATCAGGAAAAGTTAGCAGCAACCCAATCTAAGACAGGGCTTGATGAGGCTGTTGTAACAGGAACTGCTGAGTTTACAGGACAAAAAGCAGCGCTGGCTATTATGGATTCCAATTTTATCATGGCTTCAATGGGGACTGTTGTTGGTGAAAAAATTACGCGCCTTTTTGAGTATGCCAGAGAAGAACGATTACCTGTTGTCATTTTCACGGCTTCAGGAGGAGCTCGTATGCAAGAAGGTATCATGAGCTTGATGCAGATGGCTAAAATTTCTGCTGCTGTAAAGCGACATTCTAATGCTGGACTTTTTTATCTCACCGTATTGACCGACCCTACAACGGGTGGTGTCACAGCGAGTTTTGCTATGGAGGGCGATATTATTTTAGCAGAACCTCAGACCTTAATTGGCTTCGCTGGACGCCGTGTCATTGAGACAACTGTTCGTGAAACCTTGCCCGAAGGATTTCAAAAGGCAGAATTTCTTTTGGAACATGGTTTTGTTGATGCCATTGTTAAAAGAACAGAATTAAAGAAAACAATTGCTAAGCTGCTCGCATTTCATGGAGGTAGCAAATGA","9.50","6.79","31956","MALFERKNKYIRINPQRSMKKTKERETPEVPDELFAKCPACKHMIYQKDLGLEKICPKCFYNFRISAKERLAITVDGDSFQEMFTGIKSKDPLNFPAYQEKLAATQSKTGLDEAVVTGTAEFTGQKAALAIMDSNFIMASMGTVVGEKITRLFEYAREERLPVVIFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTVLTDPTTGGVTASFAMEGDIILAEPQTLIGFAGRRVIETTVRETLPEGFQKAEFLLEHGFVDAIVKRTELKKTIAKLLAFHGGSK","1641996","For other 'acc' genes see SMu1580 (accA) and SMu1582 (accC).For the alpha subunit, see SMu1580.","acetyl-CoA carboxylase beta subunit","Cytoplasm","Similarities in gapped BLAST to accD proteins. Residues 1-287 are 78% similar to gi|15900345 from S.pneumoniae and 78% similar to gi|15675593 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0353 (1e-132).","

InterPro
IPR000022
Domain

Carboxyl transferase
PF01039	$\"[140-212]T$	Carboxyl_trans

InterPro
IPR000438
Family

Acetyl-CoA carboxylase carboxyl transferase, beta subunit
PR01070	$\"[134-148]T$ $\"[168-186]T$ $\"[205-222]T$ $\"[234-245]T$ $\"[256-265]T$	ACCCTRFRASEB
TIGR00515	$\"[1-288]T$	accD

InterPro
IPR011762
Domain

Acetyl-coenzyme A carboxyltransferase, N-terminal
PS50980	$\"[39-266]T$	COA_CT_NTER

noIPR
unintegrated

unintegrated
G3DSA:3.90.226.10	$\"[23-279]T$	G3DSA:3.90.226.10
PTHR22855	$\"[63-284]T$	PTHR22855
PTHR22855:SF4	$\"[63-284]T$	PTHR22855:SF4
SSF52096	$\"[57-288]T$	SSF52096

","BeTs to 11 clades of COG0777COG name: Acetyl-CoA carboxylase beta subunitFunctional Class: IThe phylogenetic pattern of COG0777 is a--k-qvceBRhuj----inxNumber of proteins in this genome belonging to this COG is 1","***** PR01070 (Acetyl-CoA carboxylase carboxyl transferase beta subunit signature) with a combined E-value of 6.7e-48. PR01070A 134-148 PR01070B 168-186 PR01070C 205-222 PR01070D 234-245 PR01070E 256-265","Residues 132-204 are 93% similar to a (BETA CARBOXYLASE SUBUNIT TRANSFERASE) protein domain (PD001571) which is seen in Q9FBB8_STRPN.Residues 37-131 are 74% similar to a (BETA TRANSFERASE CARBOXYLASE SUBUNIT) protein domain (PD003279) which is seen in Q9CHF2_LACLA.Residues 205-284 are 83% similar to a (BETA TRANSFERASE CARBOXYLASE SUBUNIT) protein domain (PD003130) which is seen in Q9FBB8_STRPN.Residues 33-131 are 23% similar to a (BETA SUBUNIT CHLOROPLAST CHAIN) protein domain (PD030260) which is seen in ACCD_PINTH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 15:15:36 2002","Wed Feb 27 12:29:52 2002","Wed Oct 16 15:15:36 2002","Thu Apr 11 09:48:40 2002","Wed Feb 27 12:29:52 2002","Wed Feb 27 12:29:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1581 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 12:33:40 2002","","No significant hits to the NCBI PDB database.","SMU.1735c","","No significant hits to the Pfam 11.0 database","Wed Feb 27 12:29:52 2002","","","","Marini PE, Perez CA, de Mendoza D.Growth-rate regulation of the Bacillus subtilis accBC operon encoding subunits of acetyl-CoA carboxylase, the first enzyme of fatty acid synthesis.Arch Microbiol. 2001 Mar;175(3):234-7.PMID: 11357516","","Wed Feb 27 12:36:35 2002","1","","","SMU.1735c","267" "SMu1582","1644225","1642855","1371","ATGTTTAAGAAAATTTTGATTGCCAATCGTGGTGAAATCGCTGTGCGTATCATTCGAGCAGCCAGAGAATTAGGAATTGTGACTGTTGCAGTTTATTCAGAAGCAGATAAAGAATCGCTTCACACCCTCTTAGCAGATGAGGCTGTATGTGTTGGACCGGCTAAATCAACGGATTCTTACCTTAATATGAATGCTATTTTATCAGCAGCTATTGTAACTGGAGCTGAAGCTATTCATCCAGGTTTTGGTTTTTTAAGTGAAAATTCTAAATTTGCAACTATGTGTGAAGAGATGCGTATTAAGTTTATTGGTCCATCTGCATCTGTTATGGACAAAATGGGTGATAAAATTAATGCACGTTCTGAAATGCTTAAAGCCAAGGTTCCTGTTATTCCAGGGTCAGATGGGGAAGTTTTTACTGCCCAAGAAGCATTAGAAATTGCCCAAGATATTGGCTATCCTGTTATGCTGAAAGCTTCTGCTGGTGGTGGTGGTAAGGGCATCCGTAAGGTTGATAAAAAGGAAGATCTAACAGCAGCTTTTGAGTCAGCCTCTCAAGAGGCTCTATCAGCTTTTGGCAATGGCGCTATGTATCTGGAAAAAGTCATTTATCCCGCTCGCCATATAGAAGTTCAAATACTGGGGGACTCTTTTGGCAATATTATTCATCTTGGTGAACGTGATTGTTCATTGCAACGTAATAATCAAAAGGTCTTAGAAGAAAGCCCTTCTATAGCTATTGGGAAAACACTTCGTGGTAAAATGGGTGATGCAGCAGTTCGTGCCGCTAAAGCGGTTGCTTATGAAAATGCCGGAACAATTGAATTTCTCTTGGATGAGGCTTCAGGGCAATTCTATTTTATGGAAATGAACACACGTGTTCAGGTCGAACATCCTGTAACAGAATTTGTGACTGGTATTGATATCGTTAAAGAACAGATTAAAATTGCTGCTGGTCAAGAATTGACTTATCAACAAAAAGATATTGTTATTTCAGGGCATGCTATTGAATGTCGGATTAATGCAGAAAATCCTAAATTTAATTTCGCACCTAGCCCAGGTAAAGTTGAAGATCTCTTTTTACCAAGTGGTGGCGTTGGTTTACGTGTTGATAGTGCTATGTACAATAACTATACTATTCCGCCTTATTATGACAGTATGATTGCCAAAATCATTGTTCATGGAGAAAACCGCTTTGATGCTTTAATGAAAATGCAGCGTGCTCTGTATGAATTTGAAGTAACTGGTGTGGTTACGAATGCAGAGTTTCAACTGGACTTAATTTCTAATCCAAATGTTATTGCTGGTGATTATGATACTTCTTTTTTGATGGAAACTTTTTTACCCGCTTATGCTAATGATAAAGAATAG","4.90","-14.46","49688","MFKKILIANRGEIAVRIIRAARELGIVTVAVYSEADKESLHTLLADEAVCVGPAKSTDSYLNMNAILSAAIVTGAEAIHPGFGFLSENSKFATMCEEMRIKFIGPSASVMDKMGDKINARSEMLKAKVPVIPGSDGEVFTAQEALEIAQDIGYPVMLKASAGGGGKGIRKVDKKEDLTAAFESASQEALSAFGNGAMYLEKVIYPARHIEVQILGDSFGNIIHLGERDCSLQRNNQKVLEESPSIAIGKTLRGKMGDAAVRAAKAVAYENAGTIEFLLDEASGQFYFMEMNTRVQVEHPVTEFVTGIDIVKEQIKIAAGQELTYQQKDIVISGHAIECRINAENPKFNFAPSPGKVEDLFLPSGGVGLRVDSAMYNNYTIPPYYDSMIAKIIVHGENRFDALMKMQRALYEFEVTGVVTNAEFQLDLISNPNVIAGDYDTSFLMETFLPAYANDKE","1642871","For other 'acc' genes see SMu1580 (accA) and SMu1581 (accD).","acetyl-CoA carboxylase biotin carboxylase subunit","Cytoplasm","Similarities in gapped BLAST to accC proteins. Residues 1-454 are 82% similar to gi15675594 from S.pyogenes. Residues 1-451 are 80% similar to gi15900344 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0352 (0.0).","

InterPro
IPR001760
Family

Opsin
PS00238	$\"[258-274]?$	OPSIN

InterPro
IPR004549
Family

Acetyl-CoA carboxylase, biotin carboxylase
TIGR00514	$\"[1-452]T$	accC

InterPro
IPR005479
Domain

Carbamoyl-phosphate synthase L chain, ATP-binding
PF02786	$\"[115-330]T$	CPSase_L_D2
PS00866	$\"[153-167]?$	CPSASE_1
PS00867	$\"[287-294]?$	CPSASE_2

InterPro
IPR005481
Domain

Carbamoyl-phosphate synthetase large chain, N-terminal
PF00289	$\"[1-113]T$	CPSase_L_chain

InterPro
IPR005482
Domain

Biotin carboxylase, C-terminal
PF02785	$\"[337-444]T$	Biotin_carb_C

InterPro
IPR011054
Domain

Rudiment single hybrid motif
SSF51246	$\"[331-454]T$	Rudmnt_hyb_motif

InterPro
IPR011761
Domain

ATP-grasp fold
PS50975	$\"[120-318]T$	ATP_GRASP

InterPro
IPR011764
Domain

Biotin carboxylation region
PS50979	$\"[1-448]T$	BC

InterPro
IPR013816
Domain

ATP-grasp fold, subdomain 2
G3DSA:3.30.470.20	$\"[86-452]T$	ATP_grasp_subdomain_2

InterPro
IPR013817
Domain

Pre-ATP-grasp fold
G3DSA:3.40.50.20	$\"[1-85]T$	Pre-ATP_grasp

noIPR
unintegrated

unintegrated
PTHR18866	$\"[4-443]T$	PTHR18866
SSF52440	$\"[1-115]T$	SSF52440
SSF56059	$\"[116-330]T$	SSF56059

","BeTs to 12 clades of COG0439COG name: Biotin carboxylaseFunctional Class: IThe phylogenetic pattern of COG0439 is amt-YQ-CeBRhuj----inxNumber of proteins in this genome belonging to this COG is 3","***** IPB001882 (Biotin-requiring enzymes attachment site) with a combined E-value of 1.1e-89. IPB001882A 75-95 IPB001882B 104-132 IPB001882C 152-169 IPB001882D 208-243 IPB001882E 266-280 IPB001882F 293-302 IPB001882G 333-351***** IPB000901 (Carbamoyl-phosphate synthase) with a combined E-value of 1.2e-13. IPB000901 148-171***** IPB000291 (D-alanine--D-alanine ligase) with a combined E-value of 1.8e-06. IPB000291B 75-112 IPB000291C 153-190 IPB000291E 243-278","Residues 54-95 are 54% similar to a (PROTEOME COMPLETE CARBOXYLASE BIOTIN) protein domain (PD377840) which is seen in Q9PN09_CAMJE.Residues 293-443 are 79% similar to a (CARBOXYLASE BIOTIN LIGASE ACETYL-COA PYRUVATE PROTEOME) protein domain (PD000755) which is seen in Q9CHF3_LACLA.Residues 218-292 are 52% similar to a (CARBOXYLASE BIOTIN PEPTIDE PRECURSOR) protein domain (PD253426) which is seen in O67449_AQUAE.Residues 57-97 are 56% similar to a (PROTEOME COMPLETE BIOTIN FATTY) protein domain (PD337090) which is seen in P71538_MYCTU.Residues 59-92 are 85% similar to a (CARBOXYLASE BIOTIN PYRUVATE LIGASE PROTEOME COMPLETE) protein domain (PD371458) which is seen in Q9FBB9_STRPN.Residues 126-292 are 42% similar to a (LIGASE SYNTHETASE CARBOXYLASE COMPLETE PROTEOME) protein domain (PD000180) which is seen in Q9K3W3_STRCO.Residues 3-52 are 90% similar to a (CARBOXYLASE BIOTIN PYRUVATE PROTEOME LIGASE COMPLETE) protein domain (PD000820) which is seen in Q9FBB9_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 25 08:41:58 2006","Wed Feb 27 12:38:37 2002","Tue Jul 25 08:41:58 2006","Thu Apr 11 09:49:16 2002","Wed Feb 27 12:38:37 2002","Wed Feb 27 12:38:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1582 is paralogously related (blast p-value < 1e-3) to SMu0784, and SMu0045.","Wed Feb 27 12:41:07 2002","Tue Jul 25 08:41:58 2006","pdb1DV1A Chain A, Structure Of Biotin Carboxylase (Apo) >gi9... 447 1e-126pdb1DV2A Chain A, The Structure Of Biotin Carboxylase, Mutant... 446 3e-126pdb1CE8A Chain A, Carbamoyl Phosphate Synthetase From Escheri... 71 4e-013","SMU.1736c","","Residues 1 to 113 (E-value = 1.8e-47) place SMu1582 in the CPSase_L_chain family which is described as Carbamoyl-phosphate synthase L chain, N-terminal domain (PF00289)Residues 115 to 330 (E-value = 2.7e-102) place SMu1582 in the CPSase_L_D2 family which is described as Carbamoyl-phosphate synthase L chain, ATP binding domain (PF02786)Residues 337 to 444 (E-value = 4.2e-51) place SMu1582 in the Biotin_carb_C family which is described as Biotin carboxylase C-terminal domain (PF02785)","Tue Jul 25 08:41:58 2006","","","","Marini PE, Perez CA, de Mendoza D.Growth-rate regulation of the Bacillus subtilis accBC operon encoding subunits of acetyl-CoA carboxylase, the first enzyme of fatty acid synthesis.Arch Microbiol. 2001 Mar;175(3):234-7.PMID: 11357516Marini P, Li SJ, Gardiol D, Cronan JE Jr, de Mendoza D.The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fattyacid synthesis.J Bacteriol. 1995 Dec;177(23):7003-6.PMID: 7592499","","Wed Feb 27 13:05:47 2002","1","","","SMU.1736c","45" "SMu1583","1644814","1644392","423","ATGATTGACATTAGCAAAATTCGTGAAGCTCTTCCTCATCGTTATCCAATATTATTGGTTGATCGTGTTCTTGAAGTTAGTGATGATGAAATTGTTGCCATTAAGAATGTAACCATTAATGAACCTTTTTTCAATGGTCATTTTCCCCAATATCCTGTTATGCCGGGTGTTCTGATTATGGAAGCATTGGCACAAACAGCAGGTGTTCTGGAATTATCAAAAAAAGAGAATACAGGGAAACTTGTCTTTTATGCAGGTATGGATAAGGTGAAATTTAAAAAACAAGTTGTTCCTGGAGATCAACTTGTTATGACGGCTAAGTTTGTTAAGCGTCGTGGAACAATTGCAGTAGTTGAAGCTAAGGCAGAAGTAGATGGGAAATTGGCTGCAAGTGGTACCTTAACTTTTGCCATTGGAAATTGA","9.70","2.47","15355","MIDISKIREALPHRYPILLVDRVLEVSDDEIVAIKNVTINEPFFNGHFPQYPVMPGVLIMEALAQTAGVLELSKKENTGKLVFYAGMDKVKFKKQVVPGDQLVMTAKFVKRRGTIAVVEAKAEVDGKLAASGTLTFAIGN","1644408","For other 'fab' genes see SMu1585 (fabF); SMu1586 (fabG); SMu1587 (fabD); SMu1588 (fabK); SMu1590 (fabH); SMu1218 (fabK) and SMu1227 (fabD).","(3R)-hydroxymyristoyl-(acyl carrier protein) dehydratase","Cytoplasm","Similarities in gapped BLAST to fabZ proteins. Residues 1-140 are 92% similar to gi15900343 from S.pneumoniae. Residues 2-239 are 89% similar to gi15675595 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0351 (5e-71).","

InterPro
IPR010084
Domain

Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ
TIGR01750	$\"[2-138]T$	fabZ

InterPro
IPR013114
Domain

Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ
PF07977	$\"[11-133]T$	FabA

noIPR
unintegrated

unintegrated
PD838104	$\"[17-133]T$	PD838104
G3DSA:3.10.129.10	$\"[3-138]T$	G3DSA:3.10.129.10
SSF54637	$\"[1-138]T$	SSF54637

","BeTs to 8 clades of COG0764COG name: 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratasesFunctional Class: IThe phylogenetic pattern of COG0764 is -----qvcEB-Huj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB001143 (Bacterial thioester dehydrase) with a combined E-value of 3.2e-69. IPB001143A 6-19 IPB001143B 21-74 IPB001143C 82-124","Residues 40-131 are 95% similar to a (CARRIER DEHYDRATASE COMPLETE PROTEOME) protein domain (PD005671) which is seen in Q9FBC0_STRPN.Residues 40-129 are 45% similar to a (LIPID DEHYDRATASE SYNTHESIS LYASE) protein domain (PD226032) which is seen in FABZ_HAEIN.Residues 2-39 are 68% similar to a (CARRIER DEHYDRATASE LIPID COMPLETE) protein domain (PD416034) which is seen in Q9CHF4_LACLA.Residues 2-39 are 84% similar to a (DEHYDRATASE PROTEOME COMPLETE CARRIER) protein domain (PD414454) which is seen in Q9FBC0_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jul 26 10:44:24 2006","Wed Jul 26 10:44:24 2006","Wed Jul 26 10:43:05 2006","Thu Apr 11 09:53:17 2002","Wed Feb 27 13:07:09 2002","Wed Feb 27 13:07:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1583 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Feb 27 13:09:51 2002","Wed Jul 26 10:43:05 2006","pdb1MKAA Chain A, E. Coli Beta-Hydroxydecanoyl Thiol Ester De... 167 5e-043","SMU.1737c","","Residues 45 to 132 (E-value = 3.7e-22) place SMu1583 in the 4HBT family which is described as Thioesterase superfamily (PF03061)","Wed Feb 27 13:07:09 2002","","","","Mohan S, Kelly TM, Eveland SS, Raetz CR, Anderson MS.An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis.J Biol Chem. 1994 Dec 30;269(52):32896-903.PMID: 7806516","","Wed Feb 27 13:11:48 2002","1","","","SMU.1737c","641" "SMu1584","1645272","1644811","462","ATGGCACAATTTGATACGTCAAGTCTGAGAGAATTTTCTTATAAGAATGGGACAGATGAATTGTCTTTTTCAAAAAATAGGCAGGGCTCTATCAGTTCAGTCCAAACAGTCCCCGTTCCTGCTGCTAATTCAGTTTCGACTGTTGCATCGGTAGACGCTGAAGCGGTACCAGCTATCTCTAAAAATGAAGAAAGCACAGTGGCAGCTCCAGTAGCTGAAACAGCTGAAGGGGAAATTGTTGAAAGTCCGCTTGTTGGTGTAGCTTATTTAGCCTCAGCTCCTGATAAGCCAGCTTTTATTTCAGTTGGCGACAGTGTTAAAAAAGGACAGACTTTACTTATCATTGAAGCTATGAAGGTTATGAATGAAGTTCCAGCACCAAAAGATGGCGTTGTCACTGAGATCTTAGTGGCTAATGAGGAAGTCGTTGAATTTGGAAAGGGATTGGTACGTATCAAATGA","4.40","-8.00","15980","MAQFDTSSLREFSYKNGTDELSFSKNRQGSISSVQTVPVPAANSVSTVASVDAEAVPAISKNEESTVAAPVAETAEGEIVESPLVGVAYLASAPDKPAFISVGDSVKKGQTLLIIEAMKVMNEVPAPKDGVVTEILVANEEVVEFGKGLVRIK","1644827","","biotin carboxyl carrier protein of acetyl-CoA carboxylase","Periplasm, Membrane, Extracellular","Similarities in gapped BLAST to bccP proteins. Residues 1-153 are 66% similar to gi|15900342 from S.pneumoniae and 61% similar to gi|15675596 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0350 (3e-46).","

InterPro
IPR000089
Domain

Biotin/lipoyl attachment
PF00364	$\"[78-152]T$	Biotin_lipoyl
PS50968	$\"[78-152]T$	BIOTINYL_LIPOYL

InterPro
IPR001249
Family

Acetyl-CoA biotin carboxyl carrier
PR01071	$\"[82-95]T$ $\"[99-113]T$ $\"[114-127]T$	ACOABIOTINCC

InterPro
IPR001882
Binding_site

Biotin-binding site
PS00188	$\"[109-126]T$	BIOTIN

InterPro
IPR011053
Domain

Single hybrid motif
SSF51230	$\"[74-153]T$	Hybrid_motif

noIPR
unintegrated

unintegrated
G3DSA:2.40.50.100	$\"[74-153]T$	G3DSA:2.40.50.100
PTHR23151	$\"[100-153]T$	PTHR23151
PTHR23151:SF8	$\"[100-153]T$	PTHR23151:SF8

","BeTs to 15 clades of COG0511COG name: Biotin carboxyl carrier protein of acetyl-CoA carboxylaseFunctional Class: IThe phylogenetic pattern of COG0511 is AmtKYQvceBRhuj---linxNumber of proteins in this genome belonging to this COG is 2","***** PR01071 (Acetyl-CoA biotin carboxyl carrier protein signature) with a combined E-value of 1.5e-16. PR01071A 82-95 PR01071B 99-113 PR01071C 114-127***** IPB003016 (2-oxo acid dehydrogenases acyltransferase component lipoyl binding site) with a combined E-value of 1e-11. IPB003016 101-135***** IPB001882 (Biotin-requiring enzymes attachment site) with a combined E-value of 5.6e-08. IPB001882H 90-135***** IPB001078 (2-Oxo acid dehydrogenase acyltransferase catalytic domain) with a combined E-value of 9.2e-08. IPB001078A 98-130","Residues 100-153 are 88% similar to a (BIOTIN DIHYDROLIPOAMIDE LIPOYL CARBOXYLASE TRANSFERASE) protein domain (PD000268) which is seen in Q9FBC1_STRPN.Residues 1-99 are 53% similar to a (BIOTIN CARRIER CARBOXYL CARBOXYLASE) protein domain (PD286227) which is seen in Q9FBC1_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 27 13:15:58 2002","Wed Feb 27 13:13:17 2002","Wed Oct 16 14:40:27 2002","Wed Oct 16 14:40:27 2002","Wed Feb 27 13:13:17 2002","Wed Feb 27 13:13:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1584 is paralogously related (blast p-value < 1e-3) to SMu0926, also a predicted biotin carboxyl carrier protein.","Wed Feb 27 13:19:55 2002","Wed Feb 27 13:13:17 2002","pdb|1A6X| Structure Of The Apo-Biotin Carboxyl Carrier Prote... 80 2e-016pdb|3BDO|A Chain A, Solution Structure Of Apo-Biotinyl Domain F... 75 3e-015pdb|1BDO| Structure Of The Biotinyl Domain Of Acetyl-Coenzym... 75 3e-015","SMU.1738c","","Residues 78 to 152 (E-value = 1.3e-23) place SMu1584 in the Biotin_lipoyl family which is described as Biotin-requiring enzyme (PF00364)","Wed Feb 27 13:13:17 2002","","","","Marini P, Li SJ, Gardiol D, Cronan JE Jr, de Mendoza D.The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fattyacid synthesis.J Bacteriol. 1995 Dec;177(23):7003-6.PMID: 7592499","","Wed Feb 27 13:19:07 2002","1","","","SMU.1738c","761" "SMu1585","1646534","1645302","1233","ATGACATTAAAAAGAGTTGTAGTGACAGGTTACGGCGTAACATCGCCAATCGGACATACACCAGAAGATTTTTGGAATAGTCTTCATGATGGTAAAATCGGTATTAAACCAATTACTAAGTTTGATGCTTCAGAAATTCCTGTTTTCAATGCAGGCGAAATTCAAGATTTTCCATTTGATAAATACTTTGTTAAAAAAGATAAAAATCGTATGGATACTTACTCTCTTTATGCCATTTATGCAGCCATGGAAGCTATTGAAAATGCTGCACTTGACATGGCACAAGAAATTCGTGATCGTGTTGGTGTTATTGTATCCTCAGGTATTGGTGGTTTACAAGAATTAGAAGATCAAATCATTCGTATGCATGAGCGTGGCATGAAACGCATTAAACCAATGTTTATCCCTAAAGCTCTGTCTAACATGGGAGCTGGAAATATTGCCCTCAAGATTGGCGCACAAGGAGTCTGCAAATCTATTACTACAGCTTGTGCTTCAGCTAATGATGCTATTGGTGAAGCTTTCCGTGAAATTAAATACGGTTTTCATGATGTGATTCTTGCAGGTGGTTCAGAAGCATCCATTACTAAGATTGGTATTGGTGGTTTCAACGCTTTGACTGCTCTTTCTACAACAGAGGATCCAGCGCGTTCAGCTATTCCATTTGATAAAGATCGCAATGGTTTTGTCATGGGTGAAGGTGCTGCCGTTCTTATTCTGGAAAGTCTTGAACATGCTCAAAAACGTGGGGCTAGGATTTTGGCAGAGGTTGTTGGTTATGGAAGTAACTGTGATGCCTACCATATGACAACACCGACTCCTGATGGTTCGGGTGCTGCTAAGGCTATTAAATTAGCAATTAATGAAGCAGGTATCTCACCAGAGGAAGTCAATTATGTTAATGCTCATGGTACATCAACACAGGCCAATGAAAAAGGAGAAAGCAAGGCAATCGTTGCTGTTTTAGGTAAAGATGTACCTGTCTCTTCTACAAAATCATTCACAGGCCATCTTCTTGGTGCTGCTGGCGGTGTTGAGGCTATTGCCACTATTGAAGCAATTCGTAATCATTTTGTACCTATGACAGCTGGCACTAAGGAACTTTCAGAAGATATTGAAGCGAATGTTGTTTATGGTCAAGGTCAAGAAGCAGTTATCAAATATGCTATCTCAAATACCTTTGGATTTGGCGGACACAATGCCGTTCTTGCCTTTAAGCGTTGGGAGGATTAA","5.90","-6.70","43651","MTLKRVVVTGYGVTSPIGHTPEDFWNSLHDGKIGIKPITKFDASEIPVFNAGEIQDFPFDKYFVKKDKNRMDTYSLYAIYAAMEAIENAALDMAQEIRDRVGVIVSSGIGGLQELEDQIIRMHERGMKRIKPMFIPKALSNMGAGNIALKIGAQGVCKSITTACASANDAIGEAFREIKYGFHDVILAGGSEASITKIGIGGFNALTALSTTEDPARSAIPFDKDRNGFVMGEGAAVLILESLEHAQKRGARILAEVVGYGSNCDAYHMTTPTPDGSGAAKAIKLAINEAGISPEEVNYVNAHGTSTQANEKGESKAIVAVLGKDVPVSSTKSFTGHLLGAAGGVEAIATIEAIRNHFVPMTAGTKELSEDIEANVVYGQGQEAVIKYAISNTFGFGGHNAVLAFKRWED","1645318","For other 'fab' genes see SMu1583 (fabZ); SMu1586 (fabG); SMu1587 (fabD); SMu1588 (fabK); SMu1590 (fabH); SMu1218 (fabK) and SMu1227 (fabD).","3-oxoacyl-(acyl-carrier-protein) synthase","Cytoplasm","Similarities in gapped BLAST to beta ketoacyl-acyl carrier protein synthases. Residues 1-410 are 72% similar to gi15902426 from S.pneumoniae and are 70% similar to gi15675597 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0349 (1e-177).","

InterPro
IPR000794
Domain

Beta-ketoacyl synthase
PTHR11712	$\"[4-410]T$	Ketoacyl_synth

InterPro
IPR014030
Domain

Beta-ketoacyl synthase, N-terminal
PF00109	$\"[4-245]T$	ketoacyl-synt
PS00606	$\"[155-171]?$	B_KETOACYL_SYNTHASE

InterPro
IPR014031
Domain

Beta-ketoacyl synthase, C-terminal
PF02801	$\"[254-366]T$	Ketoacyl-synt_C

noIPR
unintegrated

unintegrated
G3DSA:3.40.47.10	$\"[6-259]T$ $\"[262-408]T$	G3DSA:3.40.47.10
PTHR11712:SF23	$\"[4-410]T$	PTHR11712:SF23

","BeTs to 10 clades of COG0304COG name: 3-oxoacyl-(acyl-carrier-protein) synthase IFunctional Class: IThe phylogenetic pattern of COG0304 is ----YqvCEBRhuj----inxNumber of proteins in this genome belonging to this COG is 2","***** IPB000794 (Beta-ketoacyl synthase) with a combined E-value of 2.3e-07. IPB000794A 187-198 IPB000794B 218-230 IPB000794C 332-341","Residues 374-407 are 88% similar to a (SYNTHASE II BETA-KETOACYL-ACP TRANSFERASE) protein domain (PD003436) which is seen in Q9FBC2_STRPN.Residues 321-376 are 50% similar to a (PROTEOME 3-OXOACYL-ACYL COMPLETE CARRIER) protein domain (PD384192) which is seen in Q9CHF6_LACLA.Residues 4-146 are 27% similar to a (SYNTHASE HOMOLOG BETA- FATTY) protein domain (PD081657) which is seen in CEM1_YEAST.Residues 5-35 are 64% similar to a (I SYNTHASE TRANSFERASE PROTEOME) protein domain (PD389521) which is seen in Q9CHF6_LACLA.Residues 3-145 are 24% similar to a (F10G8.9) protein domain (PD397406) which is seen in Q93458_CAEEL.Residues 329-407 are 40% similar to a (SYNTHASE PROTEOME II BETA-KETOACYL-ACP) protein domain (PD063696) which is seen in Q9PCW5_XYLFA.Residues 214-300 are 58% similar to a (SYNTHASE POLYKETIDE CHAIN LENGTH) protein domain (PD063697) which is seen in Q9WZQ9_THEMA.Residues 293-407 are 30% similar to a (CFA-BETA-KETOACYLSYNTHASE) protein domain (PD063698) which is seen in P72239_PSESG.Residues 279-318 are 57% similar to a (SYNTHASE I II COMPLETE) protein domain (PD413621) which is seen in O67612_AQUAE.Residues 223-360 are 29% similar to a (FATTY ACID SYNTHASE TRANSFERASE) protein domain (PD149030) which is seen in Q04846_CORAM.Residues 3-57 are 76% similar to a (SYNTHASE II TRANSFERASE PROTEOME) protein domain (PD077301) which is seen in Q9FBC2_STRPN.Residues 140-403 are 26% similar to a (NONJ NONK) protein domain (PD360282) which is seen in Q9XDF8_BBBBB.Residues 278-318 are 58% similar to a (COMPLETE PROTEOME SYNTHASE CARRIER) protein domain (PD403763) which is seen in O34340_BACSU.Residues 70-130 are 45% similar to a (SYNTHASE TRANSFERASE II COMPLETE PROTEOME) protein domain (PD001987) which is seen in Q9FBC2_STRPN.Residues 4-306 are 19% similar to a (PROTEOME TRANSFERASE COMPLETE II) protein domain (PD321497) which is seen in Q9KBT4_BACHD.Residues 274-318 are 77% similar to a (SYNTHASE BETA-KETOACYL-ACP TRANSFERASE II) protein domain (PD349651) which is seen in Q9FBC2_STRPN.Residues 141-407 are 25% similar to a (C41A3.1) protein domain (PD067861) which is seen in Q18559_CAEEL.Residues 270-318 are 48% similar to a (CARRIER SYNTHASE ACYL) protein domain (PD381479) which is seen in Q9Z4Y3_STRCO.Residues 4-66 are 39% similar to a (F25A4.7) protein domain (PD389817) which is seen in Q9SSG8_ARATH.Residues 221-273 are 71% similar to a (SYNTHASE TRANSFERASE PHOSPHOPANTETHEINE) protein domain (PD000224) which is seen in Q9VNF5_DROME.Residues 321-372 are 80% similar to a (SYNTHASE TRANSFERASE PHOSPHOPANTETHEINE) protein domain (PD000208) which is seen in Q9FBC2_STRPN.Residues 147-211 are 69% similar to a (TRANSFERASE SYNTHASE PHOSPHOPANTETHEINE POLYKETIDE) protein domain (PD000145) which is seen in Q9FBC2_STRPN.Residues 7-62 are 46% similar to a (SYNTHASE POLYKETIDE LENGTH CHAIN) protein domain (PD001234) which is seen in Q56164_STRVL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 25 08:32:05 2006","Thu Feb 28 14:03:57 2002","Tue Jul 25 08:32:05 2006","Thu Apr 11 09:53:55 2002","Thu Feb 28 14:03:57 2002","Thu Feb 28 14:03:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1585 is paralogously related (blast p-value < 1e-3) to SMu1226, a predicted polyketide synthase.","Thu Feb 28 14:12:27 2002","Tue Jul 25 08:32:05 2006","pdb1E5MA Chain A, Beta Ketoacyl Acyl Carrier Protein Synthase... 364 1e-101pdb1KAS Beta-Ketoacyl-Acp Synthase Ii From Escherichia Col... 326 4e-090pdb1DD8A Chain A, Crystal Structure Of Beta-Ketoacyl-[acyl Ca... 193 3e-050","SMU.1739c","","Residues 4 to 246 (E-value = 3e-59) place SMu1585 in the ketoacyl-synt family which is described as Beta-ketoacyl synthase, N-terminal domain (PF00109)Residues 254 to 409 (E-value = 2.5e-57) place SMu1585 in the Ketoacyl-synt_C family which is described as Beta-ketoacyl synthase, C-terminal domain (PF02801)","Tue Jul 25 08:32:05 2006","","","","Schujman GE, Choi KH, Altabe S, Rock CO, de Mendoza D.Response of Bacillus subtilis to cerulenin and acquisition of resistance.J Bacteriol. 2001 May;183(10):3032-40.PMID: 11325930","","Thu Feb 28 14:11:26 2002","1","","","SMU.1739c","44" "SMu1586","1647317","1646583","735","ATGGAAATCAAAAATAAAAATGTTTTTATCACAGGTTCAACTCGTGGTATTGGTCTAGCTATTGCTCATAAATTTGCTCAGGCGGGAGCTAATATTGTATTAAATGGTCGCTCAGAAATTTCTCAGGACCTAGTAGCTGAATTTAAAGATTATGGTGTCAAAGTAGCGACAATTTCAGGTGATGTCTCTCATTTTGAAGATGCTAAACGTATGGTTGATGAAGCTACTGAAGCATTGGGAAGCGTTGATATCTTGGTTAATAATGCTGGAATTACTAATGATAAGCTGATGTTGAAGATGACAGAAGAGGACTTTGAAAGGGTTCTTAAGATCAATTTGACAGGTAGCTTTAACATGACTAAAGCTGTTTTGAAACCAATGACCAAAGCTCGCCAAGGTGCTATCATTAATATGTCTAGTGTTGTTGGACTTGCTGGAAACGTTGGTCAGGCTAATTACGCAGCTTCTAAAGCTGGTTTGATTGGCTTTACCAAGGCAGTTGCTCGTGAAGTTGCGGCTAGAAATATACGTGTTAACGCTATTGCACCAGGTTTTATTGAATCTGATATGACTGAACGTATTCCAAATAAGATGAAAGACGCTATGTTAAATCAAATTCCAATGAAAACATTTGGAAAGACTGAAAATGTTGCTGAAGTTGCTATGTTTTTAGCTCAACAAGATTATCTGACAGGTCAAGTTATTGCTATTGATGGCGGCATGACCATGCAATGA","9.00","1.49","26208","MEIKNKNVFITGSTRGIGLAIAHKFAQAGANIVLNGRSEISQDLVAEFKDYGVKVATISGDVSHFEDAKRMVDEATEALGSVDILVNNAGITNDKLMLKMTEEDFERVLKINLTGSFNMTKAVLKPMTKARQGAIINMSSVVGLAGNVGQANYAASKAGLIGFTKAVAREVAARNIRVNAIAPGFIESDMTERIPNKMKDAMLNQIPMKTFGKTENVAEVAMFLAQQDYLTGQVIAIDGGMTMQ","1646599","For other 'fab' genes see SMu1583 (fabZ); SMu1585 (fabF); SMu1587 (fabD); SMu1588 (fabK); SMu1590 (fabH); SMu1218 (fabK) and SMu1227 (fabD)."," 3-oxoacyl-acyl-carrier-protein reductase / 3-ketoacyl-acyl carrier protein reductase","Cytoplasm","Similarities in gapped BLAST to FabG sequences. Residues 1-244 are 78% similar to gi15675598 from S.pyogenes. Residues 1-243 are 74% similar to gi15902425 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0348 (1e-110).","

InterPro
IPR002198
Family

Short-chain dehydrogenase/reductase SDR
PR00080	$\"[80-91]T$ $\"[133-141]T$ $\"[153-172]T$	SDRFAMILY
PTHR19410	$\"[1-239]T$	ADH_short_C2
PF00106	$\"[6-172]T$	adh_short
PS00061	$\"[140-168]T$	ADH_SHORT

InterPro
IPR002347
Family

Glucose/ribitol dehydrogenase
PR00081	$\"[7-24]T$ $\"[80-91]T$ $\"[127-143]T$ $\"[153-172]T$ $\"[174-191]T$ $\"[207-227]T$	GDHRDH

InterPro
IPR011284
Family

3-oxoacyl-(acyl-carrier-protein) reductase
TIGR01830	$\"[8-242]T$	3oxo_ACP_reduc

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-243]T$	G3DSA:3.40.50.720
PTHR19410:SF87	$\"[1-239]T$	PTHR19410:SF87
SSF51735	$\"[4-241]T$	SSF51735

","BeTs to 12 clades of COG1028COG name: Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)Functional Class: RThe phylogenetic pattern of COG1028 is a--KYQVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 4","***** IPB002198 (Short-chain dehydrogenase/reductase (SDR) superfamily) with a combined E-value of 1.3e-16. IPB002198 133-168","Residues 10-176 are 25% similar to a (OXIDOREDUCTASE R119.3) protein domain (PD260605) which is seen in O61709_CAEEL.Residues 131-176 are 67% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD003795) which is seen in FABG_THEMA.Residues 8-37 are 90% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME) protein domain (PD058480) which is seen in Q9FBC3_STRPN.Residues 4-190 are 26% similar to a (PROTEOME KETOREDUCTASE C-13 COMPLETE) protein domain (PD318292) which is seen in Q9PCN7_XYLFA.Residues 8-175 are 19% similar to a (C21H7.08 PRECURSOR DEHYDROGENASE) protein domain (PD093754) which is seen in O42949_SCHPO.Residues 61-242 are 24% similar to a (OXIDOREDUCTASE PROTEOME COMPLETE LONG) protein domain (PD169769) which is seen in O59473_PYRHO.Residues 10-122 are 34% similar to a (COMPLETE PROTEOME 4-EPIMERASE REDUCTASE UDP-GLUCOSE NAD) protein domain (PD000038) which is seen in O32457_BBBBB.Residues 179-225 are 55% similar to a (OXIDOREDUCTASE DEHYDROGENASE ALCOHOL) protein domain (PD005160) which is seen in FABG_THEMA.Residues 58-120 are 77% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME) protein domain (PD126102) which is seen in Q9FBC3_STRPN.Residues 177-241 are 64% similar to a (OXIDOREDUCTASE DEHYDROGENASE COMPLETE PROTEOME NAD) protein domain (PD000197) which is seen in Q9CHF7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 18:06:07 2006","Thu Feb 28 14:23:42 2002","Wed Sep 6 18:06:07 2006","Thu Apr 11 09:54:25 2002","Thu Feb 28 14:23:42 2002","Thu Feb 28 14:23:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1586 is paralogously related (blast p-value < 1e-3) to SMu1207, a predicted acetoin reductase, to SMu0278, a predicted sorbitol-6-phosphate 2-dehydrogenase, and to SMu1340, SMu0949, SMu1919, and SMu0339, miscellaneous oxidoreductases.","Thu Feb 28 14:31:39 2002","Wed Sep 6 18:06:07 2006","pdb1EDOA Chain A, The X-Ray Structure Of Beta-Keto Acyl Carri... 214 9e-057pdb1I01A Chain A, Crystal Structure Of Beta-Ketoacyl [acyl Ca... 194 7e-051pdb1HDCA Chain A, 3-Alpha, 20-Beta-Hydroxysteroid Dehydrogena... 133 2e-032","SMU.1740c","","Residues 8 to 241 (E-value = 1e-82) place SMu1586 in the adh_short family which is described as short chain dehydrogenase (PF00106)","Thu Feb 28 14:23:42 2002","","","","Podkovyrov SM, Larson TJ.Identification of promoter and stringent regulation of transcription of the fabH, fabD and fabG genes encoding fatty acid biosynthetic enzymes of Escherichia coli.Nucleic Acids Res. 1996 May 1;24(9):1747-52.PMID: 8649995","","Thu Feb 28 14:28:42 2002","1","","","SMU.1740c","266" "SMu1587","1648252","1647332","921","ATGACAAAAACAGCATTTTTATTTGCTGGCCAAGGAGCTCAAAAACTTGGTATGGCAAGTGATTTGTATGAAATTTACCCAGTTGTCAAAGAGACTTTTAAAACCGCTCATTCAATTTTGGGATATGATGTTCGTGCTTTGATTGATAATGATGAAGAAAAGCTAAATCAAACACGTTATGCACAGCCAGCGATTTTAACAACTTCAGTAGCTATTTATCGTCTTTTGAAAGAAAAAGGTTATCAACCAGACATTGTTGCTGGACTGTCACTAGGAGAATACTCTGCTCTTGTTGCAGCCGGTGCCATTTCATTTGAAGATGCCTTAGCCTTGGTTGCCAAACGTGGTGAATTTATGGAAACAGCAGCACCCGCTGGAGTGGGGAAAATGGTTGCTGTTATGAATACTGACCCTAGGCTCATTGAAGAGATTTGTCAGAAAGCCAGCTCTAAAGGCATTGTTAGTCCAGCTAATTATAATACTCCTACACAAATTGTTATTGGTGGTGAAGTAGCAGCTGTTGATTATGCTGTGGAACTTTTAAAGGGAGCTGGTAGTAAACGTTTGATTTCTCTTAAAGTTTCTGGTCCCTTTCATACGGCTCTTTTGAAATCTGCTAGTCAAAAATTGGCTCAAGCTTTGGAAAATATTAAATTTTCAGATTTCATGCTTCCACTAGTGGGGAACACTAAAGCTGAAATTATGAAGGAACAGGAGATTAAACCTTTGCTTGCTCGTCAAGTCAAAGAACCTGTTCGCTTCTATGAATCTATTGCTGTAATGCAAAAATTTGGTGTGAATAACTATGTCGAAATTGGACCTGGTAAGGTCTTGAGTGGTTTTGTGAAAAAGATTGATAAATCTGCAAAGATCTCAGCTGTTGAAGACTTAGCTAGTTTGCAGGCTTTCTTAGATAACTAG","8.90","2.45","33029","MTKTAFLFAGQGAQKLGMASDLYEIYPVVKETFKTAHSILGYDVRALIDNDEEKLNQTRYAQPAILTTSVAIYRLLKEKGYQPDIVAGLSLGEYSALVAAGAISFEDALALVAKRGEFMETAAPAGVGKMVAVMNTDPRLIEEICQKASSKGIVSPANYNTPTQIVIGGEVAAVDYAVELLKGAGSKRLISLKVSGPFHTALLKSASQKLAQALENIKFSDFMLPLVGNTKAEIMKEQEIKPLLARQVKEPVRFYESIAVMQKFGVNNYVEIGPGKVLSGFVKKIDKSAKISAVEDLASLQAFLDN","1647348","For other 'fab' genes see SMu1583 (fabZ); SMu1585 (fabF); SMu1586 (fabG); SMu1588 (fabK); SMu1590 (fabH); SMu1218 (fabK) and SMu1227 (fabD).","[acyl-carrier-protein] S-malonyltransferase","Cytoplasm","Matches in gapped BLAST to malonyl CoA-acyl carrier protein transacylases. Residues 1-305 are 71% similar to gi15900339 from S.pneumoniae and 69% similar to gi15672755 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0347 (1e-110).","

InterPro
IPR001227
Domain

Acyl transferase region
G3DSA:3.40.366.10	$\"[1-306]T$	Ac_transferase_reg

InterPro
IPR004410
Family

Malonyl CoA-acyl carrier protein transacylase
TIGR00128	$\"[2-289]T$	fabD

InterPro
IPR014043
Domain

Acyl transferase
PF00698	$\"[61-190]T$	Acyl_transf_1

noIPR
unintegrated

unintegrated
PTHR10982	$\"[4-303]T$	PTHR10982
PTHR10982:SF4	$\"[4-303]T$	PTHR10982:SF4
SSF52151	$\"[2-305]T$	SSF52151
SSF55048	$\"[126-195]T$	SSF55048

InterPro
IPR004136
Domain

2-nitropropane dioxygenase, NPD
PF03060	$\"[2-304]T$	NPD

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-211]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51412	$\"[1-305]T$	SSF51412

","BeTs to 7 clades of COG2070COG name: Dioxygenases related to 2-nitropropane dioxygenaseFunctional Class: RThe phylogenetic pattern of COG2070 is a---yqv--bR-uj-------Number of proteins in this genome belonging to this COG is 2","***** IPB001295 (Dihydroorotate dehydrogenase) with a combined E-value of 6.9e-09. IPB001295H 163-193***** IPB001093 (IMP dehydrogenase / GMP reductase) with a combined E-value of 9.8e-09. IPB001093B 6-48 IPB001093D 164-203","Residues 113-194 are 41% similar to a (DEHYDROGENASE OXIDASE OXIDOREDUCTASE BIOSYNTHESIS FMN) protein domain (PD000662) which is seen in Q9FMG0_ARATH.Residues 191-301 are 66% similar to a (PROTEOME COMPLETE DIOXYGENASE) protein domain (PD032844) which is seen in Q9FBC5_STRPN.Residues 191-306 are 39% similar to a (TRANS-2-ENOYL-ACP II REDUCTASE) protein domain (PD397509) which is seen in Q9EZA7_ZYMMO.Residues 8-111 are 82% similar to a (PROTEOME COMPLETE DIOXYGENASE) protein domain (PD010873) which is seen in Q9FBC5_STRPN.Residues 113-190 are 73% similar to a (PROTEOME COMPLETE DIOXYGENASE) protein domain (PD024891) which is seen in Q9FBC5_STRPN.Residues 191-301 are 36% similar to a (PROTEOME COMPLETE) protein domain (PD407583) which is seen in Q9WZQ7_THEMA.Residues 184-253 are 37% similar to a (PROTEOME COMPLETE NMB1452 NMA1666) protein domain (PD358387) which is seen in Q9JTR4_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 14:33:10 2002","Thu Feb 28 14:58:32 2002","Wed Oct 16 14:33:10 2002","Thu Apr 11 09:55:20 2002","Thu Feb 28 14:58:32 2002","Thu Feb 28 14:58:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1588 is paralogously related (blast p-value < 1e-3) to SMu1218, a predicted enoyl-(acyl-carrier-protein) reductase, to SMu1957, a predicted inosine monophosphate dehydrogenase, and to SMu1118, a predicted dihydroorotate dehydrogenase.","Thu Feb 28 15:14:12 2002","","No significant hits to the NCBI PDB database.","SMU.1742c","","Residues 2 to 304 (E-value = 9.1e-105) place SMu1588 in the NPD family which is described as 2-nitropropane dioxygenase (PF03060)","Thu Feb 28 14:58:32 2002","24380114","","","Heath RJ, Su N, Murphy CK, Rock CO.The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.J Biol Chem. 2000 Dec 22;275(51):40128-33.PMID: 11007778","","Thu Feb 28 15:02:03 2002","1","","","SMU.1742c","264" "SMu1589","1649547","1649323","225","ATGGCAGTATTTGAAAAAGTACAAGAAATTATTGTTGAGGAACTCGGCAAAGATACAGATGAAGTTAAATTAGAAACAACTTTTGATGAACTTGATGCAGATTCCCTTGATGTCTTTCAAGTTATTTCCGAAATTGAAGATGAGTTTGACATTCAAATCGAATCTGAAGATGGACTTAACACAGTTGGTGATTTAGTTGCTTTTGTTGAAGAAAAAACAAAATAA","3.60","-18.99","8367","MAVFEKVQEIIVEELGKDTDEVKLETTFDELDADSLDVFQVISEIEDEFDIQIESEDGLNTVGDLVAFVEEKTK","1649339","For other 'acp' genes see SMu0023 (ACP),(acpP); SMu1671 (acpS) and SMu1376 (acpA).","acyl carrier protein","Cytoplasm","Matches in gapped BLAST to acyl carrier proteins. Residues 1-74 are 87% similar to gi|15675601 from S.pyogenes and 81% similar to gi|15900337 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0345 (7e-32).","

InterPro
IPR003231
Family

Acyl carrier protein (ACP)
PD000887	$\"[30-74]T$	Acyl_carrier

InterPro
IPR006163
Domain

Phosphopantetheine-binding
PF00550	$\"[5-69]T$	PP-binding
PS50075	$\"[3-70]T$	ACP_DOMAIN

InterPro
IPR009081
Family

Acyl carrier protein-like
G3DSA:1.10.1200.10	$\"[3-71]T$	ACP_like
SSF47336	$\"[3-72]T$	ACP_like

noIPR
unintegrated

unintegrated
PTHR20863	$\"[2-73]T$	PTHR20863

","BeTs to 13 clades of COG0236COG name: Acyl carrier proteinFunctional Class: IThe phylogenetic pattern of COG0236 is ----yqVceBRhUjgpolinxNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 3-64 are 82% similar to a (ACYL CARRIER PHOSPHOPANTETHEINE FATTY) protein domain (PD000887) which is seen in Q9FBC6_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 14:32:37 2002","Thu Feb 28 15:03:26 2002","Wed Oct 16 14:32:37 2002","Wed Apr 3 10:55:56 2002","","Thu Feb 28 15:03:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1589 is paralogously related (blast p-value < 1e-3) to SMu0023, also a predicted acp.","Thu Feb 28 15:10:48 2002","","No significant hits to the NCBI PDB database.","SMU.1743c","","Residues 5 to 69 (E-value = 3.4e-11) place SMu1589 in the PP-binding family which is described as Phosphopantetheine attachment site (PF00550)","Thu Feb 28 15:03:26 2002","","","","Wong HC, Liu G, Zhang YM, Rock CO, Zheng J.The solution structure of acyl carrier protein from mycobacterium tuberculosis.J Biol Chem. 2002 Feb 1 PMID: 1182590Roujeinikova A, Baldock C, Simon WJ, Gilroy J, Baker PJ, Stuitje AR, Rice DW, Rafferty JB, Slabas AR.Crystallization and preliminary X-ray crystallographic studies on acyl-(acyl carrier protein) from Escherichia coli.Acta Crystallogr D Biol Crystallogr. 2002 Feb 1;58(Pt 2):330-2.PMID: 11807267","","Thu Feb 28 15:10:09 2002","1","","","SMU.1743c","895" "SMu1590","1650584","1649607","978","ATGACTTTTGCAAAGATTAGTCAAGCAGCATATTATGTACCATCACAGGTTGTCACCAATGATGATTTATCTAAAATAATGGATACCAGTGATGAATGGATTACAAGTCGTACGGGAATAAGAGAGCGCCGTATTAGTCAATCCGAAGATACCAGTGACTTAGCCAGTCAGGTGGCCAAAGAACTTTTAAAAAAAGCCTCATTAAAGGCGAAAGAGATTGATTTTATTATTGTTGCTACAATTACTCCGGATGCAATGATGCCATCAACAGCTGCTTGTGTCCAAGCGAAAATTGGTGCAGTGAATGCTTTTGCTTTCGATTTAACTGCCGCCTGCAGTGGATTTATTTTTGCACTTTCAGCTGCGGAAAAAATGATTAAATCCGGTCAGTACCAGAAAGGTTTAGTTATCGGTGCAGAAGTTCTATCTAAAATCATCGATTGGTCGGATCGAACAACAGCTGTTCTTTTTGGAGATGGAGCTGGCGGTGTTCTTTTAGAAGCAGATTCTTCTGAACATTTTTTATTTGAATCTATTCATTCAGATGGCAGTCGTGGTGAAAGTTTGACATCAGGTGAACACGCTGTTTCGTCACCCTTTTCACAGGTTGATAAAAAAGATAACTGTTTTCTAAAAATGGATGGTCGAGCTATATTTGACTTTGCTATTCGTGATGTGTCAAAAAGTATTTCGATGCTCATTAGGAAGTCAGATATGCCTGTAGAAGCGATTGATTATTTCTTATTACATCAGGCTAATATTCGTATTTTGGATAAAATGGCTAAAAAAATTGGCGCTGATAGAGAAAAATTTCCTGCTAATATGATGAAGTATGGTAATACCAGTGCAGCAAGTATTCCTATTTTATTAGCCGAATGTGTCGAAAATGGAACTATAGAGCTAAATGGTTCACACACTGTTCTCCTGAGCGGGTTCGGTGGGGGTTTGACATGGGGCAGTTTAATTGTTAAAATTTAG","5.50","-4.97","35104","MTFAKISQAAYYVPSQVVTNDDLSKIMDTSDEWITSRTGIRERRISQSEDTSDLASQVAKELLKKASLKAKEIDFIIVATITPDAMMPSTAACVQAKIGAVNAFAFDLTAACSGFIFALSAAEKMIKSGQYQKGLVIGAEVLSKIIDWSDRTTAVLFGDGAGGVLLEADSSEHFLFESIHSDGSRGESLTSGEHAVSSPFSQVDKKDNCFLKMDGRAIFDFAIRDVSKSISMLIRKSDMPVEAIDYFLLHQANIRILDKMAKKIGADREKFPANMMKYGNTSAASIPILLAECVENGTIELNGSHTVLLSGFGGGLTWGSLIVKI","1649623","For other 'fab' genes see SMu1583 (fabZ); SMu1585 (fabF); SMu1586 (fabG); SMu1587 (fabD); SMu1588 (fabK); SMu1218 (fabK) and SMu1227 (fabD).","3-oxoacyl-[acyl-carrier-protein] synthase III","Membrane, Cytoplasm","Matches in gapped BLAST to beta-ketoacyl-acyl carrier protein synthase III sequences. Residues 1-325 are 69% similar to gi15212446 from S.pneumoniae and 65% similar to >gi15675602 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0344 (1e-119).","

InterPro
IPR004655
Family

Beta-ketoacyl-acyl carrier protein synthase III (FabH)
TIGR00747	$\"[2-325]T$	fabH

InterPro
IPR013747
Domain

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
PF08541	$\"[234-325]T$	ACP_syn_III_C

InterPro
IPR013751
Domain

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
PF08545	$\"[106-183]T$	ACP_syn_III

noIPR
unintegrated

unintegrated
G3DSA:3.40.47.10	$\"[4-177]T$ $\"[223-323]T$	G3DSA:3.40.47.10
SSF53901	$\"[4-324]T$	SSF53901

","BeTs to 12 clades of COG0332COG name: 3-oxoacyl-[acyl-carrier-protein] synthase IIIFunctional Class: IThe phylogenetic pattern of COG0332 is Amtkyq-ceBRhuj--o-inxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 12-295 are 20% similar to a (SYNTHASE HMG-COA PROTEOME COMPLETE) protein domain (PD004407) which is seen in O26883_METTH.Residues 156-223 are 66% similar to a (III SYNTHASE PROTEOME BETA-KETOACYL-ACP) protein domain (PD413057) which is seen in Q9FBC7_STRPN.Residues 54-155 are 68% similar to a (III SYNTHASE) protein domain (PD397240) which is seen in Q9CHG0_LACLA.Residues 73-324 are 39% similar to a (SYNTHASE CHALCONE TRANSFERASE ACYLTRANSFERASE) protein domain (PD000453) which is seen in FABH_CAMJE.Residues 3-51 are 73% similar to a (III SYNTHASE) protein domain (PD003207) which is seen in Q9FBC7_STRPN.Residues 5-319 are 24% similar to a (PROTEOME COMPLETE PA0998) protein domain (PD270250) which is seen in Q9I4X1_PSEAE.Residues 154-323 are 29% similar to a (PROTEOME COMPLETE SYNTHASE) protein domain (PD281060) which is seen in Q9PMZ6_CAMJE.Residues 244-323 are 45% similar to a (III SYNTHASE) protein domain (PD259222) which is seen in Q9Z4Y5_STRCO.Residues 12-154 are 24% similar to a (GUMO) protein domain (PD121795) which is seen in O34266_XANCA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 17:48:18 2006","Thu Feb 28 15:15:31 2002","Wed Sep 6 17:48:18 2006","Thu Apr 11 09:55:55 2002","","Thu Feb 28 15:15:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1590 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Feb 28 15:22:41 2002","Wed Sep 6 17:48:18 2006","pdb1HN9A Chain A, Crystal Structure Of Beta-Ketoacyl-Acp Synt... 222 3e-059pdb1EBLA Chain A, The 1.8 A Crystal Structure And Active Site... 217 2e-057pdb1HNHA Chain A, Crystal Structure Of Beta-Ketoacyl-Acp Synt... 214 1e-056","SMU.1744c","","No significant hits to the Pfam 11.0 database","Thu Feb 28 15:15:31 2002","","","","Khandekar SS, Gentry DR, Van Aller GS, Warren P, Xiang H, Silverman C, Doyle ML, Chambers PA, Konstantinidis AK, Brandt M, Daines RA, Lonsdale JT.Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH).J Biol Chem. 2001 Aug 10;276(32):30024-30.PMID: 11375394Qiu X, Janson CA, Smith WW, Head M, Lonsdale J, Konstantinidis AK.Refined structures of beta-ketoacyl-acyl carrier protein synthase III.J Mol Biol. 2001 Mar 16;307(1):341-56.PMID: 11243824Qiu X, Janson CA, Konstantinidis AK, Nwagwu S, Silverman C, Smith WW, Khandekar S, Lonsdale J, Abdel-Meguid SS.Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.J Biol Chem. 1999 Dec 17;274(51):36465-71.PMID: 10593943","","Thu Feb 28 15:22:41 2002","1","","","SMU.1744c","263" "SMu1591","1651018","1650584","435","TTGGATTATAAACAAATTAATACCTATTTAGTTGATATTTTCAATAAAATTATGATTATCGAAGAGATGAGCTTGAAAACAAGTCAATTTAACGATGTGTCTTTAAAAGAGATGCATACGGTAGATATTATTGGAAAAAATGCCAATGTGACACCGAGTGATATTGCTCATGAGTTATTAGTAACTTTGGGAACGGTTACGACCAGCTTAAATAAGCTTGAAAAAAAAGGTTATATTGAACGGACGCGTTCACAACTTGATAGGCGCGTTGTTTATTTAACCCTGACACAAAAAGGAAGACTGCTTTATCGTTTACATAATAGGTTTCATAAAAATGTGGTTAATCGAATCACAGAAGCAATGGATGCGACGGAGCTTGGTGCTTTGGAGAAGGGGTTAAGAAACCTTCATCAATTTCTTGAGGGGTTAGTTTAA","10.00","4.20","16598","MDYKQINTYLVDIFNKIMIIEEMSLKTSQFNDVSLKEMHTVDIIGKNANVTPSDIAHELLVTLGTVTTSLNKLEKKGYIERTRSQLDRRVVYLTLTQKGRLLYRLHNRFHKNVVNRITEAMDATELGALEKGLRNLHQFLEGLV","1650600","","transcriptional regulator, MarR family","Cytoplasm","Matches in gapped BLAST to MarR family transcriptional regulators. Residues 1-144 are 62% similar to gi15675603 from S.pyogenes. Residues 1-143 are 52% similar to gi15900335 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0343 (6e-48).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PR00598	$\"[50-66]T$ $\"[67-82]T$ $\"[86-102]T$ $\"[116-136]T$	HTHMARR
PF01047	$\"[33-102]T$	MarR
SM00347	$\"[26-126]T$	HTH_MARR
PS50995	$\"[1-138]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[33-106]T$	no description

","BeTs to 5 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class: KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","***** IPB000835 (Bacterial regulatory protein, MarR family) with a combined E-value of 2.6e-14. IPB000835 66-99","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 1 07:19:40 2002","Thu Jul 6 13:33:51 2006","Thu Jul 6 13:33:51 2006","Mon Apr 15 09:12:50 2002","Fri Mar 1 07:18:26 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1591 is paralogously related (blast p-value < 1e-3) to SMu0574, SMu1812, and SMu0111, all predicted transcriptional regulators.","Mon Apr 15 09:12:50 2002","","No significant hits to the NCBI PDB database.","SMU.1745c","","Residues 33 to 136 (E-value = 1.7e-19) place SMu1591 in the MarR family which is described as MarR family (PF01047)","Fri Mar 1 07:18:26 2002","24380117","","","","","","1","","","SMU.1745c","760" "SMu1592","1652138","1651347","792","ATGGATTTTAAGGAAATTCTGTACAATGTGGATAATGGTGTGGCGACTTTAACGCTGAATCGTCCGGAGGTTTCTAATGGATTTAATATCCCTATTTGTGAGGAAATTTTGAAGGCCATTGATATTGCTAAAAAGGATGACACAGTACAAATTTTACTGATTAATGCCAATGGGAAAGTCTTTTCAGTTGGTGGCGATCTGGTTGAGATGCAAAGAGCTGTTGATGCAGATGATGTACAATCTCTTGTTCGCATTGCAGAACTTGTCAATAAAATTTCTTTTGCTTTAAAACGTTTACCTAAGCCGGTTGTCATGAGTACAGATGGTGCAGTTGCAGGTGCTGCAGCTAATATAGCGGTAGCTGCAGACTTTTGTATTGCCAGTGACAAAACACGCTTTATTCAAGCCTTTGTGAATGTCGGTTTGGCCCCTGATGCCGGAGGACTTTTCTTATTAACGAGAGCCATTGGTATTACTCGTGCAACACAACTTGCCATGACCGGTGAAGCTTTAAATGCAGAGAAAGCTTTGGAATACGGTATTGTTTACAAAGTCTGTGAGCCAGAGAAACTAGAAAAAATAACAGATCGTGTCATTACACGTTTGAAACGTGGCTCAGTTAATTCTTATAAAGCCATTAAAGAAATGGTTTGGCAAAGTTCATTTGCAGGTTGGCAGGAATATGAGGATCTAGAATTAGAATTGCAAAAGTCATTAGCATTTACAAATGATTTTAAAGAGGGAGTGCGTGCTTATACAGAGAAACGCCGTCCTAAATTTACAGGAAAGTAA","5.70","-1.13","28913","MDFKEILYNVDNGVATLTLNRPEVSNGFNIPICEEILKAIDIAKKDDTVQILLINANGKVFSVGGDLVEMQRAVDADDVQSLVRIAELVNKISFALKRLPKPVVMSTDGAVAGAAANIAVAADFCIASDKTRFIQAFVNVGLAPDAGGLFLLTRAIGITRATQLAMTGEALNAEKALEYGIVYKVCEPEKLEKITDRVITRLKRGSVNSYKAIKEMVWQSSFAGWQEYEDLELELQKSLAFTNDFKEGVRAYTEKRRPKFTGK","1651363","","enoyl-CoA hydratase/trans-2, cis-3-decenoyl-ACP isomerase","Cytoplasm","This sequence corresponds to GI:50253369 in GenBank.Similarities in gapped BLAST to enoyl-CoA hydratase sequences: Residues 4-263 are 60% simialar to gi15900334 from S.pneumoniae. Residues 1-263 are 58% similar to gi15675604 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0342 (2e-81).","

InterPro
IPR001114
Family

Adenylosuccinate synthetase
SM00788	$\"[38-244]T$	no description

InterPro
IPR001753
Domain

Enoyl-CoA hydratase/isomerase
PF00378	$\"[15-187]T$	ECH

noIPR
unintegrated

unintegrated
G3DSA:3.90.226.10	$\"[3-261]T$	no description
PTHR11941	$\"[8-260]T$	ENOYL-COA HYDRATASE-RELATED

","BeTs to 5 clades of COG1024COG name: Enoyl-CoA hydratase/carnithine racemaseFunctional Class: IThe phylogenetic pattern of COG1024 is A---Yq--EBR---------xNumber of proteins in this genome belonging to this COG is 1","***** IPB001753 (Enoyl-CoA hydratase/isomerase) with a combined E-value of 1.8e-26. IPB001753A 17-28 IPB001753B 52-66 IPB001753C 102-123 IPB001753D 145-186 IPB001753E 251-256","Residues 2-66 are 40% similar to a (PROTEOME COMPLETE ECHA2 KRE1) protein domain (PD407210) which is seen in O07179_MYCTU.Residues 205-262 are 41% similar to a (COMPLETE PROTEOME HYDRATASE ENOYL-COA ISOMERASE ACID) protein domain (PD001362) which is seen in Q9HL00_THEAC.Residues 181-260 are 32% similar to a (ENOYL-COA HYDRATASE PAAG LYASE) protein domain (PD308129) which is seen in Q9ETY7_BBBBB.Residues 14-67 are 42% similar to a (ISOMERASE COMPLETE PROTEOME HYDRATASE) protein domain (PD166985) which is seen in Q9K6A5_BACHD.Residues 133-180 are 56% similar to a (HYDRATASE ENOYL-COA ACID PROTEOME) protein domain (PD378884) which is seen in O84979_PSEPU.Residues 17-106 are 33% similar to a (HYDRATASE ENOYL-COA COMPLETE PROTEOME ACID LYASE FATTY) protein domain (PD000523) which is seen in Q9YEI7_AERPE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 14:28:19 2002","Tue Feb 1 11:18:34 2005","Tue Feb 1 11:18:34 2005","Wed Oct 16 14:28:19 2002","Fri Mar 1 07:27:52 2002","Fri Mar 1 07:27:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1592 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 14:28:19 2002","Tue Feb 1 11:18:34 2005","pdb1DUBD Chain D, 2-Enoyl-Coa Hydratase, Data Collected At 10... 89 8e-019pdb1NZYA Chain A, 4-Chlorobenzoyl Coenzyme A Dehalogenase Fro... 81 2e-016pdb1NZYB Chain B, 4-Chlorobenzoyl Coenzyme A Dehalogenase Fro... 80 2e-016","SMU.1746c","","Residues 15 to 187 (E-value = 2.2e-30) place SMu1592 in the ECH family which is described as Enoyl-CoA hydratase/isomerase family (PF00378)","Fri Mar 1 07:27:52 2002","24380118","","Fozo EM, Quivey RG.The fabM gene product of Streptococcus mutans is responsible for the synthesis of monounsaturated fatty acids and is necessary for survival at low pH.J Bacteriol. 2004 Jul;186(13):4152-8.PMID: 15205416","","Thu Feb 3 15:31:26 2005","","1","","","SMU.1746c","526" "SMu1593","1652944","1652300","645","ATGGCAACTAAAGCAGTCATTTTTGATATGGATGGTGTTCTTTTTGATACAGAAGGTTTTTATTATCGAAGGCGAGAAATTTTTTTAAATGATAAAGGAATTTCCATCAAACATATACCACCAGCATTCTTTATTGGGGGGAATATGAAGCAGGTTTGGCAAAAGATATTGGAAGATGATTATGCTAACTGGGATGTTGAACAGTTACAAAAGGATTATACTAGTTATAAAAATAAACATCCTCTGCCTTACCAAAATTTGATTTTTCCCGATGTTAAAGTCATTTTAGAAAAACTCAAGCAGCATCAATTTAAAATAGCTTTAGCATCTAGTTCAACTAAATCAGATATCTTACTGGCGCTCAATAAGACAGGGATTTATGATTATTTTGACCTTGTTTTATCGGGAGAAGAATTTCCTGAGAGCAAGCCCCATCCTGCGATTTATAATGAAGCTGCCTATCAGTTGGGTTTTCCTAAATCAGAATTACTGATTATTGAAGATAGTGAGAAAGGGATTGCTGCTGGAGTATCTGCTGGCATAGAAGTTTGGGCTATCAAAGACAGAACATTTGGACTTAATCAAAGAGCTGCTAGTCGCTTGTTTTCTAATTTGACAGAAGTGGTTGATTTTCTTTTAAAATAA","5.80","-3.03","24435","MATKAVIFDMDGVLFDTEGFYYRRREIFLNDKGISIKHIPPAFFIGGNMKQVWQKILEDDYANWDVEQLQKDYTSYKNKHPLPYQNLIFPDVKVILEKLKQHQFKIALASSSTKSDILLALNKTGIYDYFDLVLSGEEFPESKPHPAIYNEAAYQLGFPKSELLIIEDSEKGIAAGVSAGIEVWAIKDRTFGLNQRAASRLFSNLTEVVDFLLK","1652316","","possible phosphatase","Cytoplasm, Extracellular","Matches in gapped BLAST to phosphatase sequences and hypothetivcal proteins. Residues 1-212 are 50% similar to gi15672725 from L.lactis. Residues 4-208 are 44% similar to gi15674711 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0340 (3e-70).","

InterPro
IPR005833
Family

Haloacid dehydrogenase/epoxide hydrolase
PR00413	$\"[3-14]T$ $\"[48-61]T$ $\"[99-112]T$ $\"[130-146]T$ $\"[148-168]T$	HADHALOGNASE

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[3-189]T$	Hydrolase

InterPro
IPR006402
Domain

HAD-superfamily hydrolase, subfamily IA, variant 3
TIGR01509	$\"[5-186]T$	HAD-SF-IA-v3

InterPro
IPR006439
Family

HAD-superfamily hydrolase, subfamily IA, variant 1
TIGR01549	$\"[5-180]T$	HAD-SF-IA-v1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[88-207]T$	G3DSA:3.40.50.1000
PTHR18901	$\"[1-213]T$	PTHR18901
SSF56784	$\"[1-212]T$	SSF56784

","BeTs to 8 clades of COG0546COG name: Predicted phosphatasesFunctional Class: RThe phylogenetic pattern of COG0546 is a-TkyQ-CEBRhuj--oL---Number of proteins in this genome belonging to this COG is 4","***** PR00413 (Haloacid dehalogenase/epoxide hydrolase family signature) with a combined E-value of 1.5e-08. PR00413A 3-14 PR00413E 130-146 PR00413F 148-168","Residues 1-89 are 52% similar to a (PROTEOME COMPLETE YHFA) protein domain (PD392473) which is seen in Q9CHI8_LACLA.Residues 91-184 are 52% similar to a (PROTEOME COMPLETE HYDROLASE PHOSPHATASE DEHALOGENASE) protein domain (PD000816) which is seen in Q9CHI8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 1 07:32:37 2002","Wed Jul 26 10:14:16 2006","Wed Jul 26 10:14:16 2006","Fri Jan 3 15:23:23 2003","Fri Mar 1 07:31:43 2002","Fri Mar 1 07:31:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1593 is paralogously related (blast p-value < 1e-3) to SMu1146, a conserved hypothetical protein/possible phosphatase.","Fri Mar 1 07:32:37 2002","","No significant hits to the NCBI PDB database.","SMU.1747c","","Residues 3 to 189 (E-value = 5.3e-21) place SMu1593 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Fri Mar 1 07:31:43 2002","24380119","","","","","","1","","","SMU.1747c","640" "SMu1594","1653043","1654401","1359","ATGAAAGTCGTAAAATTTGGTGGTAGTTCATTGGCCTCTGCAACACAATTAGAAAAAGTTCTGAATATCATAAAATCAGACGAAGAGCGACGCTTTGTTGTTGTTTCTGCTCCGGGTAAGCGTGACGCCCAAGATACAAAAGTTACAGATGCTCTCATTAGATACTATAGATCTTATACTTCAGATAAAGACGTTACTGCTGACCAATCTTGGATTATCAACCGCTACCGTGCTATTATTGATGAACTTGGCCTTGGTCAAAATATCTTAGAAAAAATTACTAAAGCTATTGTTGATCTTGCAAATTTGCCTATTGAAGATAATGATTTCCTATATGATACTTTCCTAGCCGCAGGTGAGGACAATAATGCCAAATTAATTGCCGAATACTTCAGGAAAAATGGGCTCTCTGCTCGTTATATTCACCCTAAAAAAGCAGGTATCATTGTTACAAGTGAACCCGGTAATGCTCGGATTATTCCATCCAGTTATGATAAATTAGAAGAATTGCGAGATAGTGACGAAGTTTTAGTTATTCCTGGTTTTTTCGGTGTCACAATTGATAACCAAATCTGTACTTTTTCGCGCGGTGGTTCTGATATTACTGGTTCAATTGTCGCAGCGGGTGTTAAAGCTGACCTTTATGAAAACTTTACCGATGTAGATGGTATCTTTGCAGCTCACCCAGGGGTTGTGCATAAGCCACATTCTATTTCAGAACTAACCTATCGTGAAATGCGTGAATTGGCTTACGCAGGCTTTTCAGTACTCCACGACGAGGCCTTAATCCCTGCCTATCGCGGAAAAATTCCCCTTGTTATTAAAAATACAAATAATCCCGAACATCCAGGCACAAAAATTGTTCTTGCGCATACTGGTGCCACTATACCAGTTGTTGGTATTGCCGGAGATGATGATTTTGTCAGTATTAATCTTTCCAAATATCTGATGAATAGAGAAATCGGTTTTGGTCGCAAAATTCTTCAAGTTTTAGAAGAATTGAACATTCGTTGGGAACATATTCCGACCGGTATTGATGATATGTCAATTATTTTAAGAGGCCGTGAATTGACCCCTATAAAAGAGCAAGAAATCATCTCACAATTAACTCGTAAATTAGAAGTTGACGAAGTTGAAATTGAACGCAATCTTTCTATTATCATGATTGTCGGAGAAAATATGAAAAATCACATTGGGGTGACTGCCAAAGCTGCTGAAGCATTTTCCAAAAAACATATTAACTTGGAAATGATTTCCCAAGGTTCCAGTGAAGTATCCGTCATGTTTGTTATCAAAACTGAACAAGAAAAACAAGCAGTTAGAGCCTTATACCAAACATTTTTTATGAAAGATGAGTAA","5.50","-9.59","50390","MKVVKFGGSSLASATQLEKVLNIIKSDEERRFVVVSAPGKRDAQDTKVTDALIRYYRSYTSDKDVTADQSWIINRYRAIIDELGLGQNILEKITKAIVDLANLPIEDNDFLYDTFLAAGEDNNAKLIAEYFRKNGLSARYIHPKKAGIIVTSEPGNARIIPSSYDKLEELRDSDEVLVIPGFFGVTIDNQICTFSRGGSDITGSIVAAGVKADLYENFTDVDGIFAAHPGVVHKPHSISELTYREMRELAYAGFSVLHDEALIPAYRGKIPLVIKNTNNPEHPGTKIVLAHTGATIPVVGIAGDDDFVSINLSKYLMNREIGFGRKILQVLEELNIRWEHIPTGIDDMSIILRGRELTPIKEQEIISQLTRKLEVDEVEIERNLSIIMIVGENMKNHIGVTAKAAEAFSKKHINLEMISQGSSEVSVMFVIKTEQEKQAVRALYQTFFMKDE","1654411","For other 'thr' genes see SMu0063 (thrC); SMu0877 (thrB) and SMu1441 (thrS).For other 'lys' genes see SMu0701 (lysS) and SMu1568 (lysA). ","aspartate kinase / homoserine dehydrogenase","Cytoplasm","Several matches in gapped BLAST to aspartate kinases. Residues 1-448 are 76% similar to gi:15900332 from S.pneumoniae and 62% similar to gi15672722 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0339 (0.0).","

InterPro
IPR001048
Domain

Aspartate/glutamate/uridylate kinase
G3DSA:3.40.1160.10	$\"[70-287]T$	Aa_kinase
PF00696	$\"[1-276]T$	AA_kinase
SSF53633	$\"[1-288]T$	Aa_kinase

InterPro
IPR001341
Domain

Aspartate kinase region
TIGR00657	$\"[1-449]T$	asp_kinases
PS00324	$\"[3-11]T$	ASPARTOKINASE

InterPro
IPR002912
Domain

Amino acid-binding ACT
PF01842	$\"[388-448]T$	ACT

InterPro
IPR012150
Family

Aspartate kinase
PIRSF000726	$\"[1-452]T$	Asp_kin

noIPR
unintegrated

unintegrated
PTHR21499	$\"[100-452]T$	PTHR21499
PTHR21499:SF1	$\"[100-452]T$	PTHR21499:SF1
SSF55021	$\"[374-445]T$	SSF55021

","BeTs to 14 clades of COG0527COG name: AspartokinasesFunctional Class: EThe phylogenetic pattern of COG0527 is amtKyqVcEBrHuj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB001341 (Aspartokinase, N-terminus) with a combined E-value of 1.6e-34. IPB001341A 1-13 IPB001341B 33-43 IPB001341C 119-129 IPB001341D 192-225 IPB001341E 421-447","Residues 120-287 are 69% similar to a (KINASE ASPARTOKINASE BIOSYNTHESIS) protein domain (PD000447) which is seen in Q9CHJ1_LACLA.Residues 391-448 are 58% similar to a (KINASE ASPARTOKINASE BIOSYNTHESIS) protein domain (PD002283) which is seen in Q9CHJ1_LACLA.Residues 297-390 are 61% similar to a (KINASE BIOSYNTHESIS PROTEOME) protein domain (PD102703) which is seen in Q9CHJ1_LACLA.Residues 3-445 are 22% similar to a (PROTEOME ASPARTOKINASE COMPLETE) protein domain (PD324083) which is seen in Q9KLC4_VIBCH.Residues 55-119 are 49% similar to a (PROTEOME ASPARTOKINASE COMPLETE) protein domain (PD387152) which is seen in Q9CHJ1_LACLA.Residues 413-448 are 63% similar to a (BIOSYNTHESIS KINASE ASPARTOKINASE) protein domain (PD189653) which is seen in AK3_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 25 08:18:24 2006","Tue Jul 25 08:18:24 2006","Fri May 20 13:16:13 2005","Wed Apr 3 15:09:28 2002","Fri Mar 1 13:33:14 2002","Fri Mar 1 13:33:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1594 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 1 13:38:52 2002","","No significant hits to the NCBI PDB database.","SMU.1748","","Residues 1 to 276 (E-value = 1.8e-35) place SMu1594 in the AA_kinase family which is described as Amino acid kinase family (PF00696)Residues 385 to 452 (E-value = 2.4e-07) place SMu1594 in the ACT family which is described as ACT domain (PF01842)","Fri May 20 13:16:13 2005","24380120","","","Kochhar S, Paulus H.Lysine-induced premature transcription termination in the lysC operon of Bacillus subtilis.Microbiology. 1996 Jul;142 ( Pt 7):1635-9.PMID: 8757727Lu Y, Shevtchenko TN, Paulus H.Fine-structure mapping of cis-acting control sites in the lysC operon of Bacillus subtilis.FEMS Microbiol Lett. 1992 Apr 1;71(1):23-7.PMID: 1624109","","Fri Mar 1 13:38:52 2002","1","","","SMU.1748","43" "SMu1595","1661680","1661570","111","ATGATTTTCAACAGAAGAAAGTTTTTCCAATACTTTGGGCTTTCAAAAGAAGCCATGGTTGAGCACATTCAACCCTTTATTTTAGACATTTGGCAGATTCATCTTTTCTGA","9.40","1.46","4527","MIFNRRKFFQYFGLSKEAMVEHIQPFILDIWQIHLF","1661586","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu1595 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-2]?$	signal-peptide

noIPR
unintegrated

unintegrated
tmhmm	$\"[33-53]?$	transmembrane_regions

InterPro
IPR003799
Family

Protein of unknown function DUF196
PF02647	$\"[1-93]T$	DUF196
TIGR01573	$\"[1-95]T$	cas2

","BeTs to 5 clades of COG1343COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1343 is Amt---v---r----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-89 are 52% similar to a (PROTEOME COMPLETE MJ0386 BH0342) protein domain (PD020032) which is seen in Q9KFX8_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:24:39 2002","Fri Mar 1 13:44:48 2002","Tue Oct 8 17:24:39 2002","Tue Oct 8 17:24:39 2002","","Fri Mar 1 13:44:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1597 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:24:39 2002","","No significant hits to the NCBI PDB database.","SMU.1753c","","Residues 1 to 93 (E-value = 5.2e-13) place SMu1597 in the DUF196 family which is described as Uncharacterized ACR, COG1343 (PF02647)","Fri Mar 1 13:44:48 2002","24380123","","","","","","1","","","SMU.1753c","" "SMu1598","1663131","1662736","396","ATGTTGACTTATGAGTGTCAGTCTGCCTTAGAGGCGGTTGGATTAGACAGTTATGTCGGATTTTACCATACAGATAGACCTGGTCGTGCCAGCTTAGCTTTGGATTTAGTGGAAGAATTTCGTTCTTATATTGTTGATAGATTTGTTTTTTCGTTGATAAATAAAGGACAATTAAGCAAAAAGCACTTTGACATTAAGGAAAATGGCAGTGTTATTTTGACTGAAAAAGGACGTGCTATTTTTATTGAAGCGTGGCAAAAGCGCAAGCATACGGAGGTTGAACACCCTTTCACCAAGGAAAAAGTCAAGTTAATGTTGTTACCTTATGTACAAGCTCAGCTACTATCTAAAGCTATTCGTGGAGAATTAGAATCTTATCCACCATTCTTAATCTAG","8.40","1.91","15106","MLTYECQSALEAVGLDSYVGFYHTDRPGRASLALDLVEEFRSYIVDRFVFSLINKGQLSKKHFDIKENGSVILTEKGRAIFIEAWQKRKHTEVEHPFTKEKVKLMLLPYVQAQLLSKAIRGELESYPPFLI","1662752","","conserved hypothetical protein","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-131 are 88% similar to gi|15675454 from S.pyogenes. Residues 1-130 are 53% similar to gi|15612904 from B.halodurans.SMu1598 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002729
Family

Protein of unknown function DUF48
PD008695	$\"[1-95]T$	DUF48
PF01867	$\"[8-96]T$	DUF48

","BeTs to 7 clades of COG1518COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1518 is AmtK-qv---r----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 1-49 are 44% similar to a (PROTEOME COMPLETE CJ1522C NMA0630) protein domain (PD360113) which is seen in Q9YCL8_AERPE.Residues 1-102 are 51% similar to a (PROTEOME COMPLETE MJ0378 PH0173) protein domain (PD008695) which is seen in Q9KFX9_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:23:58 2002","Fri Mar 1 13:47:26 2002","Tue Oct 8 17:23:58 2002","Tue Oct 8 17:23:58 2002","","Fri Mar 1 13:47:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1598 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:23:58 2002","","No significant hits to the NCBI PDB database.","SMU.1754c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 13:47:26 2002","24380124","","","","","","1","","","SMU.1754c","" "SMu1599","1663506","1663207","300","ATGGCAATCCTTTTACGACGTCAGCAGTATAGGCTAGCTGATAATGACCTTTCTCTGGCGTATGCCAAACGGTTTATCCTGGCAAAGATTTCAAATGCCAGAAAGTATCTATTACGGTTTCGGCGTGACCATCGAGCCAAAATAAATCAACAACTTTTTGAGGAAGTCAATACTGAGTTGACTTTTGCTCTGGAAATGGTGGCTACTGCAAGAGATAAGGATACTTTACTTGGTATTGAAGGTCAAGCTGCTAACCACTATTTCCGTGCTTTTAATGATTTAGTCTTGACAGATAAGTAG","10.60","5.47","11615","MAILLRRQQYRLADNDLSLAYAKRFILAKISNARKYLLRFRRDHRAKINQQLFEEVNTELTFALEMVATARDKDTLLGIEGQAANHYFRAFNDLVLTDK","1663223","","conserved hypothetical protein","Cytoplasm","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 3-99 are 72% similar to gi|15675454 from S.pyogenes and 31% similar to gi|15612904 from B.haldurans. SMu1599 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","BeTs to 3 clades of COG1518COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1518 is AmtK-qv---r----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 3-99 are 31% similar to a (PROTEOME COMPLETE MJ0378 PH0173) protein domain (PD008695) which is seen in Q9KFX9_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:23:27 2002","Fri Mar 1 13:50:13 2002","Tue Oct 8 17:23:27 2002","Tue Oct 8 17:23:27 2002","","Fri Mar 1 13:50:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1599 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:23:27 2002","","No significant hits to the NCBI PDB database.","SMU.1755c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 13:50:13 2002","24380125","","","","","","1","","","SMU.1755c","" "SMu1600","1663759","1663475","285","ATGAAAAAATTGTTAAATACGTTATATCTCACACAAGATAATTTTTATTTAACGCGTGAGCGAGATAATATTGTTATCAAGCAAGAGGGAGCTGTTGTTCATCGTTTCCCCTATCGGATCATTTATGGCATCGTTTGTTTTTCATACCTAGGTGCCTCACCATCTTTGATTGAACTTTGTGCCAAAAATCAAATTAACCTTTCCTTTCATACGCCTCAGGGACGATTTTGTGGCCGTTTCGTTGGGCCGGCAAATGGCAATCCTTTTACGACGTCAGCAGTATAG","10.00","5.32","10628","MKKLLNTLYLTQDNFYLTRERDNIVIKQEGAVVHRFPYRIIYGIVCFSYLGASPSLIELCAKNQINLSFHTPQGRFCGRFVGPANGNPFTTSAV","1663491","","conserved hypothetical protein","Cytoplasm, Extracellular","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 1-87 are 75% similar to gi|15675454 from S.pyogenes and 47% similar to gi|15612904 from B.halodurans.SMu1600 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 22-87 are 42% similar to a (PROTEOME COMPLETE MJ0378 PH0173) protein domain (PD008695) which is seen in Q9KFX9_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:22:31 2002","Fri Mar 1 13:52:52 2002","Tue Oct 8 17:22:31 2002","Fri Mar 1 13:52:52 2002","","Fri Mar 1 13:52:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1600 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:22:31 2002","","No significant hits to the NCBI PDB database.","SMU.1757c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 13:52:52 2002","24380126","","","","","","1","","","SMU.1757c","" "SMu1601","1664400","1663756","645","ATGTTATCAGGTATCCAGCATTTTCAATTTTGTAAAAGACAGTGGGGGCTAATTCACATCGAGCAGCAATGGGCTGAAAATGAAGCTACAGCTCATGGCCAGATTTTGCACCAAAAGGCGGATAATCCTTATATTAGGGAAAAGCGAAAGGATATTATCACTTCGCGGGCCATGCATGTTTCCTCAAAAACACTTGGTCTTTATGGAATTCTCGATGTTGTGGAATTTCATAAAGATAAAAATGGTGTTACTTTGAAAGGCAAAAGAGGAAAGTGGCTGCCCCGTATTGTTGAGTATAAGCGGGGAAAACCCAAAAGAGATACTCGCGATATTGTTCAGCTGGTAGCACAGACCATTTGTCTTGAGGAAACGTTTGGGTGTCCTATTGAGACTGGCTGTCTTTATTACCATAGCGTGAATCAAAAAAAGGTCATTGAAATTACGGAGGCATTGCGTCAAGAAGTTTTTGATTTAGCCGGACAAATGCATTATTATTATGATAATAAAATCATAGACAAGGCTGAATATTTTAAAAATTGTCCGTTATGCTCTTTAGTAGATATTTGTAAACCGCGTCTAAGTAAGAAATCTCGCAATGTAGCTAATTACATCAAGCGGCATGTGATGAGTGAGGAGAGTTTATGA","9.70","11.83","24954","MLSGIQHFQFCKRQWGLIHIEQQWAENEATAHGQILHQKADNPYIREKRKDIITSRAMHVSSKTLGLYGILDVVEFHKDKNGVTLKGKRGKWLPRIVEYKRGKPKRDTRDIVQLVAQTICLEETFGCPIETGCLYYHSVNQKKVIEITEALRQEVFDLAGQMHYYYDNKIIDKAEYFKNCPLCSLVDICKPRLSKKSRNVANYIKRHVMSEESL","1663772","","conserved hypothetical protein","Cytoplasm","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 1-212 are 71% similar to gi|15675455 from S.pyogenes. Residues 36-205 are 46% similar to gi|15612903 from B.halodurans.SMu1601 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR013343
Family

CRISPR-associated protein Cas4
TIGR00372	$\"[2-191]T$	cas4

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 36-205 are 46% similar to a (PROTEOME COMPLETE BH0340) protein domain (PD306157) which is seen in Q9KFY0_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:21:53 2002","Fri Mar 1 13:56:30 2002","Tue Oct 8 17:21:53 2002","Fri Mar 1 13:56:30 2002","","Fri Mar 1 13:56:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1601 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:21:53 2002","","No significant hits to the NCBI PDB database.","SMU.1758c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 13:56:30 2002","24380127","","","","","","1","","","SMU.1758c","" "SMu1602","1665304","1664429","876","ATGTTGGAACAAAAAATTGATTTTATGGTAACAGTTGAAGTGAGAGAAGCGAATGCAAACGGAGACCCCTTATCAGTCAATATGCCCAGAACAGACGCTAAGGACTATGGCTTGATGAGTGACGTTTCCATTAAGCGTAAAATCAGAAATCGAATGCAGGATATGGGACAGCCTATTTTTGTACAAGCTAGGGATCGGGTCGATGATTGTATTTATTCCTTGAAACAACGTTTAGAGAATAAAGAGTTCTTTGATACTGTTAAAGAGGGGAGTAAGAAGAAAAAGTCAGTTGAGAATTTTGTAAAACAAATAAATGCAGAGTGGTTAGATGTTCGTAGCTTTGGTCAGGTGTTTGCTTTTGACGGTTATTCTGCTGCTAATGTTCGGGGTCCTGTATCTATTTCTTGGGCGAAAAGCTTAGAAAAGGTTGTAACTCAAAGTATGCAAATTACCAAAAGTACAAATAGTGAATTGAATAGTAAAACTGAGTTAGAATCTAGTACTATGGGAACAAAACATTTTGTGGATTACGGTGTTTATGTCATCAAAGGTTCGATTAATCCAAATTTTGCTGAAAAAACAGGATTTTCTGATGCTGATGCAGAAATTATCAAAGAAGTGCTAGTCAGTCTCTTTGAAAATGATGCCTCTTCTGCCCGTCCGGAAGGGTCAATGCGTGTTCGTGAGGTCTTCTGGTTTACTCACTCCAACAAGCTAGGCAATGTTTCTAGTGCGCGTGTCTTTGATTTATTAGAATTTGATAAGGAGAAGCAGGATAAAGACAGCTACGAAGACTATGCTATCCATCTTAATCAAGAAGAACTGGCAGAATATGAAGCAAAAGGTTTACAGGTTGAAATTATAGAAGGGCTGTAA","5.00","-8.29","33069","MLEQKIDFMVTVEVREANANGDPLSVNMPRTDAKDYGLMSDVSIKRKIRNRMQDMGQPIFVQARDRVDDCIYSLKQRLENKEFFDTVKEGSKKKKSVENFVKQINAEWLDVRSFGQVFAFDGYSAANVRGPVSISWAKSLEKVVTQSMQITKSTNSELNSKTELESSTMGTKHFVDYGVYVIKGSINPNFAEKTGFSDADAEIIKEVLVSLFENDASSARPEGSMRVREVFWFTHSNKLGNVSSARVFDLLEFDKEKQDKDSYEDYAIHLNQEELAEYEAKGLQVEIIEGL","1664445","","conserved hypothetical protein","Cytoplasm, Periplasm","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 1-291 are 65% similar to gi|15675456 from S.pyogenes. Residues 1-290 are 49% similar to gi|15612902 from B.halodurans.SMu1602 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006482
Family

CRISPR-associated protein TM1801
PF05107	$\"[2-271]T$	DUF694
TIGR01595	$\"[2-271]T$	cas_CT1132

InterPro
IPR013418
Family

CRISPR-associated protein Csd2
TIGR02589	$\"[5-288]T$	cas_Csd2

noIPR
unintegrated

unintegrated
SSF100934	$\"[62-94]T$	SSF100934

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-290 are 49% similar to a (PROTEOME COMPLETE BH0339) protein domain (PD317632) which is seen in Q9KFY1_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:21:18 2002","Fri Mar 1 16:19:59 2002","Tue Oct 8 17:21:18 2002","Fri Mar 1 16:19:59 2002","","Fri Mar 1 16:19:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1602 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:21:18 2002","","No significant hits to the NCBI PDB database.","SMU.1760c","","Residues 2 to 271 (E-value = 1e-127) place SMu1602 in the DUF694 family which is described as Family of unknown function (DUF694) (PF05107)","Fri Mar 1 16:19:59 2002","24380128","","","","","","1","","","SMU.1760c","" "SMu1603","1666717","1665308","1410","TTGGAGAAAAAAAAACAAAAAATAGCTTTAAAAGATATTAAATTATCATTTAAAATTTTAGAGTTTGATGGTTTGAGAGACGTTTCAGTTTCAAATTTTAATGAAATGCATCATGATTTTATTAACTATATTAATAATAATTCAACTGAAATTGGCATTGGAATATGTAATATTAGCGGAAAAGAAGACAGGATTATTAAAAATCATCGTAAACCGAAAGGTGTATTTTCAAATGGAAAACTGATTTCCCAAAATAATAAAATAGCATACCTTGGTGATAGATTTCCAAATGAAAATGCTTCATCAGACATAATTAAAATTGGCTATGAAACCTCAGAAAAAATACATTTGATGATTAAGTATCTGTTGGAGAACAATAATAGTCATACTTGGTTAGGTACCTCTCAATATTTGATCAATTGGTTTAGTGATGATTTGTCAAATGATAGTCAGTTAGATATTGTCAAACCAGAGTTTGATGATTTATTTGAAGATGATGAAGAAGAAAAACAAGTTTTTATTAAACCGAATGAAGAGAATAAAAAAATTGGTTCATCTTTTGTTAGAGGTCAGAAATTATTCAGCAATAATGCTACTTATAATATTGCTATCCTGAATGAAAATAAAGGTCGTATTGCTTTAAAGTATTTTCGCCAGCTCCAAGTTTCTCAGCTGCTAAAAAATCTGGAATCATGGCAGGAGAACTACTCTTGGGAAGCAAAAACGAAAGCAGGAAACTATGAATTGAAGAAAACACCTACCTTCAATGAAATCATTAACGCTGCTTACGGTGTTGACAGAGAACGGTATTTGGAATTGGATAATGATAGTTTCCGAAGTGACCAATATCAGCAATTGGTAACAGCTTTGATTGATGGGAAGCCACTACCAAATACAATTGTTAAAAAATTAGAAGATAACATTAGACAAAGACAAAAGTATTCTAAGCACTGGTATCAAGTACAACAAGTTAGTTTAGCGGTTTTACAAAAACAATATGGAAGGGAGTTCACACCAATGTTAGATCATCAAGAAACAGATCGTTCTTATCTATTTGGACGCTTACTTGCAATTTATGAGCTGTTCGAGGCGCAGCGCTATGCTCTAGATGGCAGTAGCCAAGAACGCGTCACAAATGCTGAACGTTATTGGAATGCTTATACAGGTCAACCAGCCAAGATGATGACTCATTTAGAAAATAAAATTAAGCCTTATGAGGAAGTTTTGAAGTTGAATAAGCCTGGTATTTGGCATAAATTGGAGAAAGAAAGAAAAGAAATTATTCAATTAATGACACCGATGTATGCTCATAAAAATTTTACACAATCATTAGATTATAAATTCATTTTTGGCTACTATGCTGAAAAACAATTTTATTATACTAAACAAGCTAAAGAAAACGAGGAATAA","8.30","3.41","55303","MEKKKQKIALKDIKLSFKILEFDGLRDVSVSNFNEMHHDFINYINNNSTEIGIGICNISGKEDRIIKNHRKPKGVFSNGKLISQNNKIAYLGDRFPNENASSDIIKIGYETSEKIHLMIKYLLENNNSHTWLGTSQYLINWFSDDLSNDSQLDIVKPEFDDLFEDDEEEKQVFIKPNEENKKIGSSFVRGQKLFSNNATYNIAILNENKGRIALKYFRQLQVSQLLKNLESWQENYSWEAKTKAGNYELKKTPTFNEIINAAYGVDRERYLELDNDSFRSDQYQQLVTALIDGKPLPNTIVKKLEDNIRQRQKYSKHWYQVQQVSLAVLQKQYGREFTPMLDHQETDRSYLFGRLLAIYELFEAQRYALDGSSQERVTNAERYWNAYTGQPAKMMTHLENKIKPYEEVLKLNKPGIWHKLEKERKEIIQLMTPMYAHKNFTQSLDYKFIFGYYAEKQFYYTKQAKENEE","1665324","","conserved hypothetical protein","Cytoplasm","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 17-459 are 57% similar to gi|15675457 from S.pyogenes. Residues 35-469 are 5% similar to gi|15612901 from B.halodurans.SMu1603 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010144
Family

CRISPR-associated protein, CT1133
TIGR01863	$\"[1-467]T$	cas_Csd1: CRISPR-associated protein, Csd1 f

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 35-469 are 25% similar to a (PROTEOME COMPLETE BH0338) protein domain (PD325881) which is seen in Q9KFY2_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:20:51 2002","Fri Mar 1 16:26:01 2002","Tue Oct 8 17:20:51 2002","Fri Mar 1 16:26:01 2002","","Fri Mar 1 16:26:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1603 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:20:51 2002","","No significant hits to the NCBI PDB database.","SMU.1761c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:26:01 2002","24380129","","","","","","1","","","SMU.1761c","" "SMu1604","1667240","1666677","564","ATGGATTTATTTACTTCTCTCTTAAAAGCCTATGAAAAAGCAGAAGAAATTGGCCTGGTTGATCAACAAACGGGGGACAATCCTGTTTTGCTACCGATTTACCATGATAATAAGGTAATAAAAAATAATGATATCTATATCGAAATATTATTAGATAATGAAGGTGCTTTTTATAAGGCAAGAAAGTTTGAAATAGGTGAAAATGTGATTTTTCCTGTAACCTATGAATCTAGTAATAGAACGAGCACTAAGATAGCACCACATCCAATCGTAGATAGTTGGTACTATGTCATGTATTCGGAATTAAGAAAAGAGAAGCATCAAAGGTATCTACAAAATTTAGATAACTGGATTATCCAGACTGAAAATAATAAAGTAGAAAATTTTTTAAAAATAATTAAAAAATTTGTTGAGAATCCAGAATCAGTTGAATTAGTTTTAAATAGTGCATTTGGTTCAGATTGCCAAATACAAGAAGAGTTTGTTGATAATAACGGAAAAATTCAAGAAGGTTCACTTATTTTTGGAGAAAAAAAAACAAAAAATAGCTTTAAAAGATATTAA","5.10","-5.32","21854","MDLFTSLLKAYEKAEEIGLVDQQTGDNPVLLPIYHDNKVIKNNDIYIEILLDNEGAFYKARKFEIGENVIFPVTYESSNRTSTKIAPHPIVDSWYYVMYSELRKEKHQRYLQNLDNWIIQTENNKVENFLKIIKKFVENPESVELVLNSAFGSDCQIQEEFVDNNGKIQEGSLIFGEKKTKNSFKRY","1666693","","conserved hypothetical protein","Cytoplasm","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 1-167 are 40% similar to gi|15675457 from S.pyogenes. Residues 1-117 are 28% similar to gi|15612901 from B.halodurans.SMu1604 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF54334	$\"[12-54]T$	Stap/Strep_toxin

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-117 are 28% similar to a (PROTEOME COMPLETE BH0338) protein domain (PD325881) which is seen in Q9KFY2_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:05:31 2002","Fri Mar 1 16:30:47 2002","Tue Oct 8 17:05:31 2002","Fri Mar 1 16:30:47 2002","","Fri Mar 1 16:30:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1604 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:05:31 2002","","No significant hits to the NCBI PDB database.","SMU.1762c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:30:47 2002","24380130","","","","","","1","","","SMU.1762c","" "SMu1605","1667989","1667240","750","TTGAATTTGTATAGATCAAGAAATTTCTATGCTAGGATACGAGGAGACAGGGCACTCTTTACAAATCCTGCAACCAAAGGGGGGAGCGAAAGAAGTTCGTATTCTGTTCCTACGCGGCAAGCTTTGCAGGGAATCATAGATGGGATTTATCATAAGCCGACATTTACAAATGTTATTACTGAAGTTAAGGTCGTCAATCAAATCCAGACAGAGCTGCATGGCGTTCGTGCTTTGTTACATGACTACAGTGCAGACTTGAGCTATGTTTCATATTTGAGTGATGTGGAGTATCTAGTTAAATTCCACTTCATTTGGAATGAAAATCGTGAAGACTTGATACAGGATAGACTACCTAAGAAACATGAAGCTATTATGGAACGTTCTATTCGAAAAGGTGGCCGGCGGGATATTTTTCTTGGTACGAGAGAGTGCTTTGGCTTGGTTGATGAAATCAGTCAGGAAGAGTATGAAACCATCCCTTCTTATTACAACGGCGTCACTATTGATTTAGGTATCATGTTTCATTCTTTCGCCTATCCAACAAGTAAGGATACGCCATTGAAATCTTATTTCACCAAAACAGTGATGGAGAATGGGGCGATTAAATTTAAACCCCAATCTGAGTGTGAAATCGTAAATACTTTGTCCAGTTATGCATTCAAGTCACTTGGTCAGCTTAAATCAGTTGATGATGAATATGTTGATGATGAATATGAAGAATATGAAGCTATGGAGAAAGGGGAAGGCTAA","5.30","-6.63","28702","MNLYRSRNFYARIRGDRALFTNPATKGGSERSSYSVPTRQALQGIIDGIYHKPTFTNVITEVKVVNQIQTELHGVRALLHDYSADLSYVSYLSDVEYLVKFHFIWNENREDLIQDRLPKKHEAIMERSIRKGGRRDIFLGTRECFGLVDEISQEEYETIPSYYNGVTIDLGIMFHSFAYPTSKDTPLKSYFTKTVMENGAIKFKPQSECEIVNTLSSYAFKSLGQLKSVDDEYVDDEYEEYEAMEKGEG","1667256","Note tandem repeats at 1667288,1667318.","conserved hypothetical protein","Cytoplasm","Limited hits in gapped BLAST to conserved hypothetical proteins. Residues 3-248 are 77% similar to gi|15675458 from S.pyogenes. Residues 15-212 are 46% similar to gi|15612900 from B.halodurans.SMu1605 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010155
Family

CRISPR-associated protein, CT1134
TIGR01876	$\"[11-212]T$	cas_Cas5d: CRISPR-associated protein Cas5,

InterPro
IPR013422
Domain

CRISPR-associated protein Cas5
TIGR02593	$\"[8-52]T$	CRISPR_cas5: CRISPR-associated protein Cas5

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 15-212 are 46% similar to a (PROTEOME COMPLETE BH0337) protein domain (PD314088) which is seen in Q9KFY3_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 30 11:27:25 2002","Fri Mar 1 16:34:53 2002","Wed Oct 30 11:27:25 2002","Fri Mar 1 16:34:53 2002","","Fri Mar 1 16:34:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1605 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:04:32 2002","","No significant hits to the NCBI PDB database.","SMU.1763c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:34:53 2002","24380131","","","","","","1","","","SMU.1763c","" "SMu1606","1670492","1668084","2409","ATGAAAATGAAACTGGCGCATAAAAATAATACTGGAGAAGAGCAATCATTGGAAGATCATTCCTTTAACGTAGCCAACAAGGCAAGGGAAGATGCTGAATTTATAGGGCAAGGGGATTTATTATTTTTGCTGGGCATGTTTCATGATTTGGGGAAGGCAGATGAGAAATTCCAGAACAAATTAACCAAGAATCCCACGATGCATGTAGATCATGCCTATGCTGGTGCTAAATATTTATATGAGAAAATCAAAATACGTCTATCCGCAAAGGGTGTTGACAAAGCAACACGTTTACAATTCAACGAAATTGTTGCTTATGTTATTGCTGCTCATCATGGGATGTTCGATATTGTTGACCTTGAATCGGAGCAACATGCTTATAACAAGCTAAGAAATCGTATTGCTAGACCGAAGTCAGATTATCATTTCGATAGTGATGTGACGAATTTTGCCAACTTTTTAGAAACAAAATTGGAGCATTATGGCTATCAGGATTTAGGAATGTTAATTGATAAATCCTTTGAAAATTACCAACAAGCTCTATCAAAATTAGATTGTCAGGATAGTAGTGAGGAAGTCTATTATCAATCATGTTTTGTACGGCTATATCTATCATTATTAAAGAATGCTGACATTCTAGATACAATTAATGCTTATGGTCTGCTTATAAATCCTTTAAAACAGGAAGAAAAAATAAGACTAAATAGGTCTTATCTGGAAGCTATTGAGAAGAAGTACGGTGAGTTTGGGAGTCCAACCACAAGGCTTAATGAAATTCGCTCACAAATTGCTGAACGAGTAAAAAGTAGGGGAGAAAGTGATTCAACGGGTATCTATCGATTAGACTTACCCACTGGTGCTGGGAAGACGAATCTTAGTATGAGGTATGCTTTTCATCAATTAGTTGACCAAGATAGATCAAGATTTTTCTATATTACGCCTTTTTTATCTGTTTTGGAGCAAAATGCGGCAGCTATTAAAAAAGTTATTGGAGAAGATGGAGTACTAGAGCACCATTCAAATGTTGTACAGAACAAACAAGAGAACGAAGATAAGGGAGACGAAAAAGAGAGCTTATTACCAGAGTACTTGATAGAAAGTTGGGATAGTCCAGTCGTTTTGACATCAATGGTTCAATTTTTTCAAACTTTATTTAAAACTAAATCAGCAAATATTCGTCGTTTTTCTAGTTTAGCGAATAGTGTTTTGATTTTAGATGAAGTGCAATCATTGCCTATTGAGGTGACAGCTTTATTTAATTTAACCATGAATTTCTTAAATAAAGTTATGAACACGACTATTATCTTATGTACGGCTACACAGCCTGCTTATGACTCTACTGCTATTAAACATAAACTTTCTTATGGTGGGAAATATGGTGAAGCTACTGATATGGTCGAGTTAACTCATGATGAAAAAGAAGTCTTTTCAAGAACTGAGCTTAGAAAATTTGATGAAACTAATCAAAACTCGAAACTTTCAGATTTGGTAGATTTTGTTTTGGAGAATGATGAATCAATCCTTGTTATTTTCAATACCAAAAAGACAGTTGATAGATTTTATTCCTTACTTGAGAAGTTGACAGATAGGCCAATCTATCAGCTTTCAACGAATATGTGTGCGCAGCATAGATTGGATATTATTTCGGAAATTAAACAAGGTTTGGAAGATGGTATACCACTTATTTGTATCAGTACACAGCTAATTGAAGCGGGTGTTGATGTCGATTTTAATCACGTCATTCGCTCGTATGCAGGAATTGATTCGATTGTACAAGCTAGCGGACGTTGTAATCGTGAAGGAAAACGGGATAAGGGACAAGTTACCTTAATTAATCTGACAAGTGAAGAAGAAAATATCTCACCACTCAAAGAAATAAAAGCTAAGAAAGATGCAACAGAATATATTCTACATAAGATTTCATCGCCCATAGACACTTCACTTTTAAATCGTGATTTCTTTGAGTATTATTATGCTAATAACCAAGGTTCAATGGATTATCCCTTGGAACATGATGGTGAGTCAGTTTATGATTATTTAAGTGTTAATTTCTATCAGAAAAAAGTAGGATTTAAAGGAAAATTAAAGCAAGCCTTTAAGACTGCTGGTTTAAAAATGAATCTAATTAACAATGAAACCATTGGTATATTAGTTCCATATAGAGATGCTGCTGAAAAATTATTAATTTTAGAAGAATTGTGTAAGTCTGATTATCCATCTGAAGAAGACTATCGAGCAATTAAAGCTCTTTTAAAAGAATTGCAGTCTTATACGGTAAATGTTCGTGAACACAATCAAATACTTGAAGCCACAAAACCCTATCTTAATGGTCAAATTCAGATATTGTCAGATAGTTATTATGATGATAAAAAAGGTATTACTTTAGAATCGGCAAGTTTCCTAATGTAA","5.50","-18.41","91723","MKMKLAHKNNTGEEQSLEDHSFNVANKAREDAEFIGQGDLLFLLGMFHDLGKADEKFQNKLTKNPTMHVDHAYAGAKYLYEKIKIRLSAKGVDKATRLQFNEIVAYVIAAHHGMFDIVDLESEQHAYNKLRNRIARPKSDYHFDSDVTNFANFLETKLEHYGYQDLGMLIDKSFENYQQALSKLDCQDSSEEVYYQSCFVRLYLSLLKNADILDTINAYGLLINPLKQEEKIRLNRSYLEAIEKKYGEFGSPTTRLNEIRSQIAERVKSRGESDSTGIYRLDLPTGAGKTNLSMRYAFHQLVDQDRSRFFYITPFLSVLEQNAAAIKKVIGEDGVLEHHSNVVQNKQENEDKGDEKESLLPEYLIESWDSPVVLTSMVQFFQTLFKTKSANIRRFSSLANSVLILDEVQSLPIEVTALFNLTMNFLNKVMNTTIILCTATQPAYDSTAIKHKLSYGGKYGEATDMVELTHDEKEVFSRTELRKFDETNQNSKLSDLVDFVLENDESILVIFNTKKTVDRFYSLLEKLTDRPIYQLSTNMCAQHRLDIISEIKQGLEDGIPLICISTQLIEAGVDVDFNHVIRSYAGIDSIVQASGRCNREGKRDKGQVTLINLTSEEENISPLKEIKAKKDATEYILHKISSPIDTSLLNRDFFEYYYANNQGSMDYPLEHDGESVYDYLSVNFYQKKVGFKGKLKQAFKTAGLKMNLINNETIGILVPYRDAAEKLLILEELCKSDYPSEEDYRAIKALLKELQSYTVNVREHNQILEATKPYLNGQIQILSDSYYDDKKGITLESASFLM","1668100","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-800 are 66% similar to gi|15675459 from S.pyogenes. Residues 15-798 are 26% similar to gi|15644543 from T.maritima.SMu1606 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[526-601]T$	Helicase_C
SM00490	$\"[518-601]T$	HELICc
PS51194	$\"[492-652]T$	HELICASE_CTER

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[13-225]T$	HDc

InterPro
IPR006474
Domain

CRISPR-associated helicase Cas3, core
TIGR01587	$\"[278-629]T$	cas3_core

InterPro
IPR006483
Domain

CRISPR-associated HD
TIGR01596	$\"[5-222]T$	cas3_HD

InterPro
IPR006674
Domain

Metal-dependent phosphohydrolase, HD region, subdomain
PF01966	$\"[17-81]T$	HD

InterPro
IPR006675
Domain

HDIG
TIGR00277	$\"[13-114]T$	HDIG

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[252-476]T$	DEXDc

","BeTs to 7 clades of COG1203COG name: Predicted helicasesFunctional Class: RThe phylogenetic pattern of COG1203 is AMtK-qv-e------------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 401-602 are 40% similar to a (PROTEOME COMPLETE ATP-BINDING HELICASE) protein domain (PD011501) which is seen in Q9KFY4_BACHD.Residues 617-793 are 25% similar to a (PROTEOME ATP-BINDING COMPLETE HELICASE) protein domain (PD311872) which is seen in Q9KFY4_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:03:48 2002","Fri Mar 1 16:39:23 2002","Tue Oct 8 17:03:48 2002","Tue Oct 8 17:03:48 2002","","Fri Mar 1 16:39:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1606 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:03:48 2002","","No significant hits to the NCBI PDB database.","SMU.1764c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:39:23 2002","24380132","","","","","","1","","","SMU.1764c","" "SMu1607","1671711","1670737","975","ATGGCGGAGTCAAAGACAAAACGGTTGCTCTATTTTATGTCAGAATTGGAAAAAGGAAATCAGATTAATAAAGAGGAATATATAGCGAAGTTCAATATTAGCGATAGGACGATGAAAGAGGATGTTAGTGAACTTAAAACCAATTTAAAAGAGCTGCGTCCTAATATGCAAATTAAATTTTCACGAAAACATGCCTGCTATTTTGCTAGCTATGAGCAGGGATATGGGAATTTGAAGTATAATCAAGCAGTTATTCTGTCCAAGATTTTATTGGAGAGCAGAGCATTGCGAAAAGAGGAAGTTGCTGAAATAATTAATATTTTTGTTGAACGTGCGGTCGATGATAAGGAGCGCACAAGAATCAAAAAATTAACACAGTTTGAGCTTAATAGTTATCAGGAGTTAAAGTTTTATCAAAAATCTAATAAGTCTATTTTACCAACTATTTCTGCTATTTTCGATGCTATTGTTGATCAGCGCCCGCTTGCTTTCAGTTATACAAAGCCATCTAGCAAAGTTGAGGAATATATTGTCTTGCCGATTTCAGTCATTTTTGATAATCATTATTTTTACTGCATTTCTTACAAATTAGACAACTGTTTTCAGAGTCGGTACGAACTTCAAGAACTAAGATATTTTCGAGTTGACAGGTTTAAAACCATTCATAAATCTATTAGCAATTCAGCTTTTGCACTAACTGAAGAAGAACAAGAACGACTTATTACAGATGAACAAGTCCGCTATCAAACTTTTTCAATGCTTTCTGATCAAAAATGGGTGCGGATTCAGTTCAGGTATACAGGGCAATTCAGAGATGTATTAGAGGCGGATATTCCAAAACTTAAAATGATTAATGAATTGGAAGAAGGAATAATCTATGAGATTGAAACCTTGAGTTTACTTGGTTTTCAGAAATATATTCAACGTTTTGATGGGGACTTTGTCTTTCTGAATATAAAAAGTATCAAAAAATAA","9.00","4.61","38656","MAESKTKRLLYFMSELEKGNQINKEEYIAKFNISDRTMKEDVSELKTNLKELRPNMQIKFSRKHACYFASYEQGYGNLKYNQAVILSKILLESRALRKEEVAEIINIFVERAVDDKERTRIKKLTQFELNSYQELKFYQKSNKSILPTISAIFDAIVDQRPLAFSYTKPSSKVEEYIVLPISVIFDNHYFYCISYKLDNCFQSRYELQELRYFRVDRFKTIHKSISNSAFALTEEEQERLITDEQVRYQTFSMLSDQKWVRIQFRYTGQFRDVLEADIPKLKMINELEEGIIYEIETLSLLGFQKYIQRFDGDFVFLNIKSIKK","1670753","","conserved hypothetical protein","Cytoplasm","A single significant match at this time: residues 5-286 are 26% similar to gb|AAL94689.1, an hypothetical protein from Fusobacterium nucleatum subsp.nucleatum ATCC 25586.SMu1607 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 17:02:40 2002","Mon Oct 28 18:26:53 2002","Mon Oct 28 18:26:53 2002","Fri Mar 1 16:40:59 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1607 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 17:02:40 2002","","No significant hits to the NCBI PDB database.","SMU.1765c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:40:59 2002","24380133","","","","","","1","","","SMU.1765c","" "SMu1608","1672159","1672007","153","ATGAAAATGCCTGATTTTGAAGGTGCGGTAGTAGCTGCTGTTGCCTTGTCTAACGACATTAATATTGTAGTGACAAGAAATGTCACGGATTTTCAAGATAGCGAACTTATAATTTATTTACCCGAGGAATTTTTGGAGCGCTTGAAAAGGTAA","4.20","-4.01","5694","MKMPDFEGAVVAAVALSNDINIVVTRNVTDFQDSELIIYLPEEFLERLKR","1672023","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu1608 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:52:20 2002","Fri Mar 1 16:42:45 2002","Tue Oct 8 16:52:20 2002","Fri Mar 1 16:42:45 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1608 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:52:20 2002","","No significant hits to the NCBI PDB database.","SMU.1766c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:42:45 2002","24380134","","","","","","1","","","SMU.1766c","" "SMu1609","1672407","1672216","192","ATGAAAGTCTTACTTGATGTTAATATTTTTTTAGATTTTTTTCTTGATCGCCATAGTGTCTCAAAAGAAATTGTCCTTAAATCAGTCTATGGTGCCCATACAGCCTATATTTCTGCAAATATGCTAACGGATCTTTATTATATCATGGAAAAAGTATGGGAAAAATTGCTCGGCTGGAACTCGAAAAATTAG","7.70","0.46","7395","MKVLLDVNIFLDFFLDRHSVSKEIVLKSVYGAHTAYISANMLTDLYYIMEKVWEKLLGWNSKN","1672232","","hypothetical protein","Cytoplasm","No significant hits in gapped BLASTSMu1609 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:51:16 2002","Fri Mar 1 16:44:42 2002","Tue Oct 8 16:51:16 2002","Fri Mar 1 16:44:42 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1609 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:51:16 2002","","No significant hits to the NCBI PDB database.","SMU.1767c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:44:42 2002","24380135","","","","","","1","","","SMU.1767c","" "SMu1610","1672696","1672391","306","ATGGCTGTGTTGCTAGAGCAAGATAGAATTCAGTTGAAGAAATGGGGAAACAGCAACGCTTTTCGGATTCCACAGAAGCTTTTGAAGTCCTTGAAATTTGAACCAGATCAGGAGTTTACGATTAAGGCTGTTGATTTAGGTGGACATAAACAACTAGTTATTGAGCCTCTTGTCAGTCAAAATGACCAGTTGTCTCTTATTGAGTCTCTCTCAGGGATTTTATCAGATAGTGAAACTGTCGATGTCAAAGATTACCGTAGTGAACGTAAAGAGGAAAGGCTAAAGAAATATGAAAGTCTTACTTGA","6.00","-0.76","11628","MAVLLEQDRIQLKKWGNSNAFRIPQKLLKSLKFEPDQEFTIKAVDLGGHKQLVIEPLVSQNDQLSLIESLSGILSDSETVDVKDYRSERKEERLKKYESLT","1672407","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu1610 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
G3DSA:2.10.260.10	$\"[9-93]T$	G3DSA:2.10.260.10
SSF89447	$\"[8-87]T$	SSF89447

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:50:52 2002","Fri Mar 1 16:47:41 2002","Tue Oct 8 16:50:52 2002","Fri Mar 1 16:47:41 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1610 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:50:52 2002","","No significant hits to the NCBI PDB database.","SMU.1768c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 16:47:41 2002","24380136","","","","","","1","","","SMU.1768c","" "SMu1611","1675918","1673267","2652","ATGTCAACACAACTTTCACCTAAATACAATCCAGCCGAGGTTGAGGCTGATCGTTACCAAAAATGGCTTGATGCCGATGTTTTCAAGCCTTCTGGAGATCAAAAGGCTAAGCCTTATTCAATCGTGATTCCACCACCAAATGTGACGGGGAAATTGCACCTTGGTCACGCTTGGGACACGACTTTGCCGGATATTATTATCCGTCAAAAGCGTATGCAGGGTTTTGACACGCTCTGGCTGCCGGGGATGGATCACGCTGGTATTGCCACACAGGCCAAGGTAGAAGCTCGCTTGGCTGAAGATGGCATTTCCCGTTATGATCTTGGTCGTGAGAAATTTCTGGATAAGGTCTGGGAATGGAAGGATGAGTATGCGGCAACCATCAAGGAGCAATGGGGCAAGATGGGAATTTCTGTTGATTATTCGCGGGAACGTTTCACCCTTGATGAAGGATTGTCTAAAGCGGTCCGCAAGGTTTTCGTAGAACTCTATAAAAAAGGCTGGATTTATCGCGGCGAATTTATCATCAACTGGGACCCTAAGGCACGCACAGCTTTGTCCGACATCGAAGTCATTCATAAGGATGTGGAAGGTGCCTTCTACCATATGAATTATATGTTGGAAGATGGCTCGCGCGCTTTGGAAGTTGCGACCACGCGTCCAGAGACCATGTTTGGGGATACGGCTGTCGCTGTCAATCCAAATGATGATCGTTACAAAGATCTGATTGGACAAAATGTTATCTTGCCAATTGTTAACAAGCTGATTCCAATCGTAGCAGATGAACATGCTGACCCTGAGTTTGGAACAGGTGTTGTTAAGATCACACCTGCCCATGACCCTAACGACTTCCTCGTTGGTCAGCGCCACAATCTGCCACAAGTCAATGTTATGAACGATGACGGAACCATGAACGAACTGGCTGGCGAATTTGCTGGCATGGATCGCTTTGAAGCCCGCAAGGCAACTGTTAAGAAACTGGAAGAAATCGGCGCTCTTGTGGAAATCGAAAAGATGACCCACTCGGTTGGTCACTCAGAACGGACAGGTGTACCAATTGAGCCACGTCTGTCTACCCAGTGGTTCGTTAAGATGGACCAACTGGCTAAGAATGCCATTGCCAATCAAGACACTGATGACAAAGTGGACTTTTACCCACCGCGTTTCAATGATACCTTCCTGCAATGGATGGAAAATGTGCATGACTGGGTGATTTCCCGTCAGCTCTGGTGGGGTCACCAAATCCCTGCTTGGTACAATGCGGATGGTGACATGTATGTCGGTGAAGAGGCTCCAGAGGGTGATGGCTGGAAGCAAGATGAAGATGTGCTTGACACTTGGTTCAGCTCTGCTCTTTGGCCATTCTCAACCATGGGCTGGCCTGACACGGACTCAGAAGATTTCAAACGTTATTTCCCAACATCAACGCTGGTAACGGGTTATGACATCATTTTCTTCTGGGTGTCTCGTATGATTTTCCAATCTTTGGAATTCACTGGTTGCCGTCCTTTCCAGAATGTTCTCATCCACGGACTTATCCGTGACGAACAAGGGCGCAAGATGTCTAAATCTCTCGGTAACGGCATTGACCCTATGGATGTTGTTGACAAATACGGTGCTGATGCTTTGCGTTGGTTCCTGTCAAATGGATCTGCACCGGGTCAAGATGTGCGTTTCTCTTACGAAAAAATGGACGCTGCTTGGAATTTCATTAACAAGATTTGGAACATTTCCCGCTATATCCTCATGAATAATGAAGGCCTTAGCCTTGATCAAGCTAGCAAAAATGTTGTTTTAGTAACCAATGGCAAAGCTGGTAATGTGACGGACCGCTGGATTCTTCATAATCTCAATGAAACCATTGCCAAAGTTACTGAAAACTTCGATAAGTTCGAATTTGGTGTGGCTGGTCACATCCTTTACAATTTCATCTGGGATGAATTTGCCGACTGGTATGTGGAGTTGACCAAAGAAGTCCTTTACAGCGAAGATGAGGCTGAAAAAGTTATTACGCGTTCGGTCCTCCTTTACACCTTGGACAAAATCCTGCGTCTTCTCCATCCTATCATGCCATTTGTAACAGAAGAAATCTTCGGTCAATACGCAGATGGTTCTATCGTGACAGCAGCTTATCCAACTGTTAATCCTGCTTTTGAAAATCAAACGGCGCATTCTGGCGTGGAAAGTCTCAAAGACCTGATTCGAGCTGTACGTAATGCGCGTGCAGAAGTCAACGTAGCTCCAAGCAAACCTATCACCATTCTTGTCAAAACAAGCGATAGCAACTTGGAAGACTTTTTCAAGGCCAATGTCAACTACATCAAACGCTTCACAAACCCAGAAACACTTGAAATCAGCTCTGCCATTGCCACCCCAGAACTAGCCATGTCAGCAGTTATCACAGGTGCAGAAATCTTCCTGCCGCTGGCAGACTTGCTCAACGTTGAGGAAGAACTAGCCCGCCTCAACAAAGAACTGGCCAAATGGCAAAAAGAACTAGACATAGTTGCTAAAAAACTCAGCAACGACCGCTTTGTCCAAAATGCCAAACCTGAAATCGTCCAAAAAGAACGCGACAAACAAATCGACTACCAAACCAAATACGACGCCACAGTGGAACGGATTAAAGAGATGGAGAAACTAATTAAATAG","4.90","-32.83","100932","MSTQLSPKYNPAEVEADRYQKWLDADVFKPSGDQKAKPYSIVIPPPNVTGKLHLGHAWDTTLPDIIIRQKRMQGFDTLWLPGMDHAGIATQAKVEARLAEDGISRYDLGREKFLDKVWEWKDEYAATIKEQWGKMGISVDYSRERFTLDEGLSKAVRKVFVELYKKGWIYRGEFIINWDPKARTALSDIEVIHKDVEGAFYHMNYMLEDGSRALEVATTRPETMFGDTAVAVNPNDDRYKDLIGQNVILPIVNKLIPIVADEHADPEFGTGVVKITPAHDPNDFLVGQRHNLPQVNVMNDDGTMNELAGEFAGMDRFEARKATVKKLEEIGALVEIEKMTHSVGHSERTGVPIEPRLSTQWFVKMDQLAKNAIANQDTDDKVDFYPPRFNDTFLQWMENVHDWVISRQLWWGHQIPAWYNADGDMYVGEEAPEGDGWKQDEDVLDTWFSSALWPFSTMGWPDTDSEDFKRYFPTSTLVTGYDIIFFWVSRMIFQSLEFTGCRPFQNVLIHGLIRDEQGRKMSKSLGNGIDPMDVVDKYGADALRWFLSNGSAPGQDVRFSYEKMDAAWNFINKIWNISRYILMNNEGLSLDQASKNVVLVTNGKAGNVTDRWILHNLNETIAKVTENFDKFEFGVAGHILYNFIWDEFADWYVELTKEVLYSEDEAEKVITRSVLLYTLDKILRLLHPIMPFVTEEIFGQYADGSIVTAAYPTVNPAFENQTAHSGVESLKDLIRAVRNARAEVNVAPSKPITILVKTSDSNLEDFFKANVNYIKRFTNPETLEISSAIATPELAMSAVITGAEIFLPLADLLNVEEELARLNKELAKWQKELDIVAKKLSNDRFVQNAKPEIVQKERDKQIDYQTKYDATVERIKEMEKLIK","1673283","","valyl-tRNA synthetase","Cytoplasm","Several matches to val-tRNA synthase sequences. Residues 1-883 are 88% similar to gi|15902536 from S.pneumoniae. Residues 3-881 are 87% similar to gi|15675460 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0445 (0.0).","

InterPro
IPR001412
Family

Aminoacyl-tRNA synthetase, class I
PS00178	$\"[46-57]T$	AA_TRNA_LIGASE_I

InterPro
IPR002300
Domain

Aminoacyl-tRNA synthetase, class Ia
PF00133	$\"[17-560]T$	tRNA-synt_1

InterPro
IPR002303
Family

Valyl-tRNA synthetase, class Ia
PR00986	$\"[39-50]T$ $\"[233-250]T$ $\"[348-361]T$ $\"[440-461]T$ $\"[472-490]T$	TRNASYNTHVAL
PTHR11946:SF5	$\"[1-883]T$	tRNA-synt_val
TIGR00422	$\"[5-862]T$	valS

InterPro
IPR009008
Domain

ValRS-IleRS-LeuRS editing
SSF50677	$\"[194-343]T$	ValRS_IleRS_edit

InterPro
IPR009080
Domain

Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
SSF47323	$\"[571-830]T$	tRNAsyn_1a_bind

InterPro
IPR010978
Domain

tRNA-binding arm
SSF46589	$\"[814-879]T$	tRNA_binding_arm

InterPro
IPR013155
Domain

tRNA synthetase, valyl/leucyl, anticodon-binding
PF08264	$\"[610-757]T$	Anticodon_1

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[6-559]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
G3DSA:1.10.730.10	$\"[607-701]T$	G3DSA:1.10.730.10
PTHR11946	$\"[1-883]T$	PTHR11946
SSF52374	$\"[2-570]T$	SSF52374

","BeTs to 17 clades of COG0525COG name: Valyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0525 is amtkyqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001412 (Aminoacyl-transfer RNA synthetases class-I) with a combined E-value of 3.1e-10. IPB001412A 46-56 IPB001412B 517-527","Residues 630-698 are 62% similar to a (SYNTHETASE LIGASE ISOLEUCYL-TRNA) protein domain (PD023651) which is seen in SYV_BACSU.Residues 327-495 are 84% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000647) which is seen in Q9CDP6_LACLA.Residues 14-107 are 85% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000389) which is seen in SYV_LACCA.Residues 327-373 are 61% similar to a (LIGASE VALINE--TRNA SYNTHETASE) protein domain (PD411872) which is seen in SYV_BACSU.Residues 464-504 are 61% similar to a (SYNTHETASE TRNA AMINOACYL-TRNA VALYL) protein domain (PD329442) which is seen in O77443_GIALA.Residues 638-755 are 56% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD347709) which is seen in Q9CDP6_LACLA.Residues 573-733 are 24% similar to a (CG5414) protein domain (PD276669) which is seen in Q9VUY4_DROME.Residues 516-867 are 22% similar to a (LIGASE SYNTHETASE ATP-BINDING VALYL-TRNA) protein domain (PD011442) which is seen in O14160_SCHPO.Residues 631-715 are 55% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD001183) which is seen in SYV_LACCA.Residues 119-178 are 90% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD002670) which is seen in Q9CDP6_LACLA.Residues 792-879 are 69% similar to a (SYNTHETASE LIGASE VALYL-TRNA) protein domain (PD004138) which is seen in Q9CDP6_LACLA.Residues 517-630 are 76% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000476) which is seen in Q9CDP6_LACLA.Residues 180-324 are 70% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD004139) which is seen in SYV_LACCA.Residues 380-432 are 64% similar to a (LIGASE SYNTHETASE ATP-BINDING VALYL-TRNA) protein domain (PD382343) which is seen in SYV_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 1 16:55:11 2002","Fri Mar 1 16:50:32 2002","Wed Oct 16 14:21:47 2002","Wed Oct 16 14:21:47 2002","Fri Mar 1 16:50:32 2002","Fri Mar 1 16:50:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1611 is paralogously related (blast p-value < 1e-3) to SMu0508, SMu1766, and SMu1492, predicted isoleucyl, leucyl and methionyl tRNA synthases respectively.","Fri Mar 1 16:58:45 2002","Fri Mar 1 16:50:32 2002","pdb|1GAX|A Chain A, Crystal Structure Of Thermus Thermophilus V... 632 0.0pdb|1FFY|A Chain A, Insights Into Editing From An Ile-Trna Synt... 270 7e-073pdb|1ILE| Isoleucyl-Trna Synthetase 233 9e-062","SMU.1770c","","Residues 17 to 560 (E-value = 6.3e-289) place SMu1611 in the tRNA-synt_1 family which is described as tRNA synthetases class I (I, L, M and V) (PF00133)","Fri Mar 1 16:50:32 2002","","","","","","","1","","","SMU.1770c","54" "SMu1612","1676238","1675930","309","ATGGGGAACGCGATTATAAATTTGATTAGTAACATAGAATTTAAAAAATTACTAGATGAAACGATTCGATTTGAACTTTATCAATTTGGTTCTTCGTTAGAAAAAGAAGAGTTTAACGATATTGATTTATTGTTAATATATAAAAATAGTGAAAAAAATAAACAGAATGAAATACTAACTCTAAAGAAAATAATTAAAAGTTATTTATTTAAACAGTATCAGATTGATATTGACATCACAGTTTTATCAGAAAATGAAGAGAAAGAAAAGAAATTTCTAGAGCAAGTCAATTATATAAAAGTATATTAA","4.90","-3.00","12230","MGNAIINLISNIEFKKLLDETIRFELYQFGSSLEKEEFNDIDLLLIYKNSEKNKQNEILTLKKIIKSYLFKQYQIDIDITVLSENEEKEKKFLEQVNYIKVY","1675946","","hypothetical protein","Cytoplasm, Extracellular","No significant matches in gapped BLAST.SMu1612 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:50:32 2002","Fri Mar 1 17:02:27 2002","Tue Oct 8 16:50:32 2002","Fri Mar 1 17:02:27 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1612 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:50:32 2002","","No significant hits to the NCBI PDB database.","SMU.1771c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 17:02:27 2002","24380138","","","","","","1","","","SMU.1771c","" "SMu1613","1676620","1676210","411","ATGGTTAATTTTAGCGATGAACCGAGACCAGAGTCAGTAGTTTATTTTGAACAGATATTAGAGAGACATGGTAAGATTGTTAGATATGAAAGACCAGAAGATTTTATTTATAAGTTATTTCTTAGTGGTGGTAAGACATATTTAGTATGGTTAACTAATAAGTACACTGTATCTATTAATGATGTTGTTGAAAAGATAAATGAAGGTTTTGATGCTTTAATCACCATTAGTATGTGGAATAGCTATACGTATGAAGCTAAAGAATATGCACTACAAAAACATTTTGGTTTATTCAAAATTCAAGAATTCATGGGTGCATTAAATTACTCAGATCCATCTCAATATTATATGGGAATTGATGAAGAAGATGGTAAAAGATTGTATGGGGAACGCGATTATAAATTTGATTAG","4.70","-6.52","16210","MVNFSDEPRPESVVYFEQILERHGKIVRYERPEDFIYKLFLSGGKTYLVWLTNKYTVSINDVVEKINEGFDALITISMWNSYTYEAKEYALQKHFGLFKIQEFMGALNYSDPSQYYMGIDEEDGKRLYGERDYKFD","1676226","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu1613 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:50:15 2002","Fri Mar 1 17:06:04 2002","Tue Oct 8 16:50:15 2002","Fri Mar 1 17:06:04 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1613 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:50:15 2002","","No significant hits to the NCBI PDB database.","SMU.1772c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 17:06:04 2002","24380139","","","","","","1","","","SMU.1772c","" "SMu1614","1677548","1676613","936","ATGGACTGTTGGAGAAGGAATGGGAGGAAAGTATTGTTTGAAACAAGTGATAATATTAATCAATTTATTCGTACATTAAGAGACTTAAACGAAATTATTGAAAAAAGAGCAAAGCTTAATTTACTGGATAATGCGGTGTTAGCAGAATCTTTTTATAAAGAAATTTTAAATGCTTTATTTTCTTGGAAGTTAGAAAATTTAAATATTGAACAGTCCAATTTTGAAGCAATTGATTTAATTGATGATAAAAATAAAATTGTTGTTCAAATTTCATGTACTTGTGAGAATCAAAAAGTGCATGGTACTATTTCTAAAGATGAATTAACTAAAGAAGATTATAAGGAATACGTACTTTACTTTGTTTTTATTGGAAAACAGAATAGCAAGATTAAAAATGGTAAATATAATAATACTTCACAATTGAATTTTAATCCCAAGAAGAATATTTTTTTAACAGAAGATTTAATAAAAAAGTTTCAGGATTTAACCCCAAATTCTCAGCGTAAAGTTCTTGATATTATTCAAAATTATCTAAGTAATGAGAAAAGTGGCGAGAATATCTTATCAAAAAGAGAAATTTCAGAAAGCATTCTTGAAATTTTGGATGAGAATAGTGAAATCTTTTTTAAGTATGGTCCACATTCTAAAGTAGCTTCAACTAGTCCAATGAGTAAGTCTTCCTATAAAATTTGGAATAAGCAAAAACAAAAAATTATTGAGAATAACAAAGATATATTAAATTTGTATAGTAAACATCAATCATTTTTTAGTAGAAAAGAAAAATTGCTATTTAACAAATTTAAATCAAATGTTGAATCATTTGAATGTAATGACAAACAAAGACTAGATTCAAATGTATATGAATCATTTCCAGAAGACTTTCCAAAAATGTTAGAATCAATTATTAAAAATCAAGGAGTTAATTTAAATGGTTAA","8.80","4.56","36525","MDCWRRNGRKVLFETSDNINQFIRTLRDLNEIIEKRAKLNLLDNAVLAESFYKEILNALFSWKLENLNIEQSNFEAIDLIDDKNKIVVQISCTCENQKVHGTISKDELTKEDYKEYVLYFVFIGKQNSKIKNGKYNNTSQLNFNPKKNIFLTEDLIKKFQDLTPNSQRKVLDIIQNYLSNEKSGENILSKREISESILEILDENSEIFFKYGPHSKVASTSPMSKSSYKIWNKQKQKIIENNKDILNLYSKHQSFFSRKEKLLFNKFKSNVESFECNDKQRLDSNVYESFPEDFPKMLESIIKNQGVNLNG","1676629","","conserved hypothetical protein","Cytoplasm","Residues 16-292 are 32% similar to gi|21283478, an hypothetical protein from Staphylococcus aureus subsp. aureus MW2.SMu1614 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:49:45 2002","Mon Oct 28 18:32:31 2002","Mon Oct 28 18:32:31 2002","Fri Mar 1 17:08:27 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1614 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:49:45 2002","","No significant hits to the NCBI PDB database.","SMU.1773c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 17:08:27 2002","24380140","","","","","","1","","","SMU.1773c","" "SMu1615","1678095","1677838","258","ATGATGTCATACGAACAGGAATTTTTACGAGAATTTGAAGCTTGGGTCAATTCACAAGTGACCATTAACGAAATGGCCATGAATGCTAGTCGTAAAATCATTGAAGAAGATAAAGATGAGCGTGCAGCAGATGCCTATATTCGTTATGAAAGCAAACTGGATGCCTATAAATTTATCCAAGGAAAATTTGAAAATTATAAGGCTGGCAAAGGATTTCACGATATACCAGACGGTCTTTTTGGTGAGAGAAATTATTGA","4.70","-4.76","10072","MMSYEQEFLREFEAWVNSQVTINEMAMNASRKIIEEDKDERAADAYIRYESKLDAYKFIQGKFENYKAGKGFHDIPDGLFGERNY","1677854","","conserved hypothetical protein","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 2-85 are 73% similar to gi|15902531 from S.pneumoniae. Residues 2-85 are 64% similar to gi|15675464 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0440 (1e-35).","

InterPro
IPR015026
Family

Domain of unknown function DUF1912
PF08930	$\"[2-85]T$	DUF1912

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 2-85 are 58% similar to a (PROTEOME COMPLETE) protein domain (PD391212) which is seen in Q9CDP4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:49:10 2002","Fri Mar 1 17:13:27 2002","Tue Oct 8 16:49:10 2002","Fri Mar 1 17:13:27 2002","","Fri Mar 1 17:13:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1615 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:49:10 2002","","No significant hits to the NCBI PDB database.","SMU.1774c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 17:13:27 2002","24380141","","","","","","1","","","SMU.1774c","899" "SMu1616","1678767","1678588","180","ATGTGGATCGTAGGAAAGGATAGGAAGAATGAAAAAGGTTTTGACTTTGTTAACGGTTTTTGGATGGCAATGATATTGGTGGCTTGTTTGTCTGGCAGCAATACTGAACATAAAACTTCTGTTTCTAATATGGATGGAACATATTATGAGTTTTATAAGCTTAAGAAAGTAATTGGATAA","9.30","2.17","6770","MWIVGKDRKNEKGFDFVNGFWMAMILVACLSGSNTEHKTSVSNMDGTYYEFYKLKKVIG","1678604","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST.SMu1616 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
PS51257	$\"[1-29]T$	PROKAR_LIPOPROTEIN

InterPro
IPR007337
Family

RelB antitoxin
PF04221	$\"[1-77]T$	RelB
TIGR02384	$\"[1-77]T$	RelB_DinJ

InterPro
IPR004465
Family

Ribonucleotide reductase Class Ib, NrdI
PF07972	$\"[7-144]T$	Flavodoxin_NdrI

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.360	$\"[7-150]T$	G3DSA:3.40.50.360
PIRSF005087	$\"[5-153]T$	NrdI
SSF52218	$\"[3-152]T$	SSF52218

","BeTs to 4 clades of COG1780COG name: NrdI protein involved in ribonucleotide reductionFunctional Class: FThe phylogenetic pattern of COG1780 is --------eBr---gp-----Number of proteins in this genome belonging to this COG is 1","***** IPB003707 (Glutaredoxin-like enzyme NrdI) with a combined E-value of 8e-18. IPB003707A 7-23 IPB003707B 90-107 IPB003707C 113-151","Residues 8-140 are 61% similar to a (PROTEOME COMPLETE RIBONUCLEOTIDE) protein domain (PD006143) which is seen in Q9KWY3_STREQ.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 14:19:39 2002","Fri Mar 1 17:20:42 2002","Wed Oct 16 14:19:39 2002","Mon Apr 1 15:49:37 2002","Fri Mar 1 17:20:42 2002","Fri Mar 1 17:20:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1618 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 1 17:32:14 2002","","No significant hits to the NCBI PDB database.","SMU.1777c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 17:20:42 2002","","","","Eklund H, Uhlin U, Farnegardh M, Logan DT, Nordlund P.Structure and function of the radical enzyme ribonucleotide reductase.Prog Biophys Mol Biol. 2001;77(3):177-268.PMID: 11796141Reichard P.Ribonucleotide reductases: the evolution of allosteric regulation.Arch Biochem Biophys. 2002 Jan 15;397(2):149-55. Review.PMID: 11795865 ","","Fri Mar 1 17:32:14 2002","1","","","SMU.1777c","864" "SMu1619","1681347","1679968","1380","ATGAATTTACGAGTAAAACAAAAGATTCCCTTGAAAATCAAGAGAATGGGAATTAACGGTGAAGGAATTGGCTTTTATAAGAGAACCTTAGTTTTTGTTCCCGGTGCTCTGAAAGGTGAAGAGATTTTTTGTCAAATAACCAGTGTTAAACACAATTTCGTGCAAGCCAGACTATTGACCATCAATAAAAAATCTAAATTTCGGGTGCGGCCTGCTTGTCCTATTTATGAGGAATGTGGCGGCTGTCAAATCATGCATTTACGTTATGATAAACAATTGGATTTCAAAAAAGATTTGCTAAAGCAAGCTTTGAAAAAATTTAAGCCGCAAGGTTATGAGACCTATGACATTCGAGCGACAATTGGAATGGAACACCCTCAGCATTATCGCGCCAAGTTACAATTTCAGACGAGAAAATTTGGCGGTTCTGTTAGAGCGGGACTTTTCAAAGAGCAAAGTCATCATTTGGTAGATATTAAAGATTGTTTGATACAAGATGAGCTGACCCAAAAAATCGTCAATCGAGTCTGTCAGCTTTTGGACGACTACAATATCCCTGTTTATGACGAACGGCGTCATTTTGCTGGTGTCAGAACTATCATGGTCAGAAAGTCACAAGCCACCAATCAAGTTCAGTTGATTTTTGTAACCAGTAAGGAAGTTAATCTCGTCGGAATTATTCGTGATTTGACAGGATATTTTCCAGAAATTAAGACGGTTGCCGTTAATTTTAATTCCAGCAAATCCAGTGCTATTTATGGTCAGAAAACAGAAATTCTCTGGGGTATTGATAGCATATCAGAGGAAGTTTTAGATTATTCCTTTTCTTTATCTCCCAGAGCCTTTTATCAACTTAATCCTCAGCAGACGCAAGTTCTTTATCATCAAGCACTTCAAGCTCTTGATGTGACTGCAGAAGATCATTTAATTGATGCTTACTGTGGTGTCGGTAGTATTGGTCTTGCTTTTGCTAATAAAGTAAAATCAGTTAGAGGGATGGATATTATTCCTGAAGCTATTACAGATGCTAAAAGAAATGCTGAGCGTATGGGATACACAAACACCTATTATGAAATGGGGAAAGCCGAAAATGTTATTCCAAAATGGTACAAAGACGGCTATCAAGCATCGGCGCTTATTGTTGATCCACCTAGAACAGGACTTGATGAGAAACTTTTAAAAACTCTGCTAACCTATCAGCCAGAAAAAATGGTTTATGTCTCTTGTAATGTTTCAACTCTTGCCAGAGATTTGGTTCAATTGGTTAAAGTCTATGAAGTCAATTATATCCAATCGGTCGATATGTTCCCTCATACAGCAAGAACTGAGGCTGTTGTTAAATTAGTAAAACGAAAACAAAATAGTTGTTCTAAAAAGTAA","10.10","22.00","52497","MNLRVKQKIPLKIKRMGINGEGIGFYKRTLVFVPGALKGEEIFCQITSVKHNFVQARLLTINKKSKFRVRPACPIYEECGGCQIMHLRYDKQLDFKKDLLKQALKKFKPQGYETYDIRATIGMEHPQHYRAKLQFQTRKFGGSVRAGLFKEQSHHLVDIKDCLIQDELTQKIVNRVCQLLDDYNIPVYDERRHFAGVRTIMVRKSQATNQVQLIFVTSKEVNLVGIIRDLTGYFPEIKTVAVNFNSSKSSAIYGQKTEILWGIDSISEEVLDYSFSLSPRAFYQLNPQQTQVLYHQALQALDVTAEDHLIDAYCGVGSIGLAFANKVKSVRGMDIIPEAITDAKRNAERMGYTNTYYEMGKAENVIPKWYKDGYQASALIVDPPRTGLDEKLLKTLLTYQPEKMVYVSCNVSTLARDLVQLVKVYEVNYIQSVDMFPHTARTEAVVKLVKRKQNSCSKK","1679984","","RNA methyltransferase, TrmA family","Cytoplasm","Several matches in gapped BLAST to RNA methyltransferases and to hypothetical proteins. Residues 1-451 are 68% similar to gi15675488 from S.pyogenes and 67% similar to gi15903759 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0413 (0.0).","

InterPro
IPR001566
Family

23S rRNA methyltransferase/RumA
TIGR00479	$\"[16-443]T$	rumA

InterPro
IPR002792
Domain

Deoxyribonuclease/rho motif-related TRAM
PF01938	$\"[2-60]T$	TRAM
PS50926	$\"[2-60]T$	TRAM

InterPro
IPR010280
Family

(Uracil-5)-methyltransferase
PF05958	$\"[88-451]T$	tRNA_U5-meth_tr
PS01230	$\"[382-413]T$	TRMA_1
PS01231	$\"[433-443]N$	TRMA_2

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[276-369]T$	G3DSA:3.40.50.150
PTHR11061	$\"[11-453]T$	PTHR11061
PTHR11061:SF2	$\"[11-453]T$	PTHR11061:SF2
SSF50249	$\"[7-66]T$	Nucleic_acid_OB
SSF53335	$\"[67-451]T$	SSF53335

","BeTs to 9 clades of COG2265COG name: SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferaseFunctional Class: JThe phylogenetic pattern of COG2265 is --------eBr---gp-----Number of proteins in this genome belonging to this COG is 2","***** IPB001566 (RNA methyltransferase trmA family) with a combined E-value of 1.1e-34. IPB001566A 309-350 IPB001566B 379-389 IPB001566C 404-413 IPB001566D 425-448","Residues 178-289 are 27% similar to a (METHYLTRANSFERASE PROTEOME RNA COMPLETE) protein domain (PD332150) which is seen in Q9UZR7_PYRAB.Residues 302-361 are 50% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME ARGININE) protein domain (PD006760) which is seen in O31503_BACSU.Residues 256-346 are 34% similar to a (METHYLTRANSFERASE TRNA) protein domain (PD035416) which is seen in Y885_CHLPN.Residues 358-396 are 64% similar to a (PROTEOME COMPLETE METHYLTRANSFERASE YFJO) protein domain (PD405632) which is seen in Q9CDP0_LACLA.Residues 307-363 are 49% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD030986) which is seen in Q9CGB9_LACLA.Residues 185-297 are 26% similar to a (PROTEOME METHYLTRANSFERASE COMPLETE) protein domain (PD338157) which is seen in Q9KL20_VIBCH.Residues 306-354 are 65% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE TRNA) protein domain (PD292646) which is seen in Q9CDP0_LACLA.Residues 299-357 are 49% similar to a (PROTEOME YFJO COMPLETE) protein domain (PD386579) which is seen in O31545_BACSU.Residues 63-294 are 41% similar to a (METHYLTRANSFERASE PROTEOME RNA COMPLETE 2.1.1.-) protein domain (PD007501) which is seen in O31545_BACSU.Residues 401-450 are 84% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME RNA TRNA) protein domain (PD004091) which is seen in Q9CDP0_LACLA.Residues 190-398 are 24% similar to a (PROTEOME COMPLETE) protein domain (PD121811) which is seen in O54099_STRCO.Residues 7-56 are 60% similar to a (PROTEOME COMPLETE METHYLTRANSFERASE RNA) protein domain (PD007943) which is seen in Q9KEF5_BACHD.Residues 262-388 are 27% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE RNA) protein domain (PD099587) which is seen in O66617_AQUAE.Residues 203-302 are 45% similar to a (PROTEOME COMPLETE Y FF) protein domain (PD396785) which is seen in Q9CDP0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 25 10:47:32 2006","Tue Jul 25 10:47:32 2006","Tue Jul 25 10:47:32 2006","Wed Oct 16 14:17:04 2002","Sat Jan 5 09:20:04 2002","Sat Jan 5 09:20:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1619 is paralogously related (blast p-value < 1e-3) to SMu0715, also a predicted RNA methyltransferase.","Sat Jan 5 09:24:49 2002","","No significant hits to the NCBI PDB database.","SMU.1779c","","Residues 2 to 60 (E-value = 7.4e-05) place SMu1619 in the TRAM family which is described as TRAM domain (PF01938)Residues 88 to 451 (E-value = 7.1e-07) place SMu1619 in the tRNA_U5-meth_tr family which is described as tRNA (Uracil-5-)-methyltransferase (PF05958)","Tue Jul 25 10:47:32 2006","24380145","","","Thanedar S, Dineshkumar TK, Varshney U.The Mere Lack of rT Modification in Initiator tRNA Does Not Facilitate Formylation-Independent Initiation in Escherichia coli.J Bacteriol. 2001 Dec;183(24):7397-402.PMID: 11717300Frees D, Varmanen P, Ingmer H.Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation of non-native proteins andconcomitantly increases stress tolerance in Lactococcus lactis.Mol Microbiol. 2001 Jul;41(1):93-103.PMID: 11454203 ","","Sat Jan 5 09:26:26 2002","1","","","SMU.1779c","53" "SMu1620","1681383","1682159","777","ATGAAAATTACTAAAATTGAAAAGAAAAAAAGACTTTATCTGATTGAAATTGATGAAGCTGAACATTTCTATATCACTGAAGATACCATTGTCCATTTTATGCTCAGCAAGAATAAGGAAATTCTTCCTGAGCAACTAGAAGAAATCAAGACCTTTGCCCAATTTTCTTATGGTAAAAACCTTGCTCTGTATTATCTTTCTTTTAAACAGCGCACGGAAAAAGAAGTCAAAGATTATCTGATAAGACATGATATTAACACTACTGTTATTTCTCAGATTCTCACCCAATTAAAAGAGGAAAAGTGGCTTGATGACAGTAAATATATCGACAATATATTGCAGCAAAATCTTCATTCTGGTGATAAAGGCGCCTTTGTCCTTAAACAGAAATTACTTCAAAAAGGAATCGAATCTCAATTAATTGAAGACATGTTAAAAGATTTTGATTTCAGCAGTATTTGCATTAAAACGGCCCAAAAACTCCTTAAAAAATATCAAAGTAAGCTCCCAAAAAGAGCTCTCAAGGATAAACTTAAGCAAGCCTTAACGACCAAAGGATTTTCCTATCAAGAAGCCCAAATAGCTCTTGAAGATTTAGATATTGAAAACAATTCTGAAAATGAAGAAGAACTTATTTATAAAGAACTAGATAAACAATATCGGAAATATAGTAAAAAATATGAAAATTATGAACTCAGACAACGCCTGACACAAAGCTTAGCCAGAAAAGGCTTTGCCTTTGATGCTATTAAAAATGCCTTACGGGAGTATTTGTAA","9.50","4.94","30722","MKITKIEKKKRLYLIEIDEAEHFYITEDTIVHFMLSKNKEILPEQLEEIKTFAQFSYGKNLALYYLSFKQRTEKEVKDYLIRHDINTTVISQILTQLKEEKWLDDSKYIDNILQQNLHSGDKGAFVLKQKLLQKGIESQLIEDMLKDFDFSSICIKTAQKLLKKYQSKLPKRALKDKLKQALTTKGFSYQEAQIALEDLDIENNSENEEELIYKELDKQYRKYSKKYENYELRQRLTQSLARKGFAFDAIKNALREYL","1682169","","RecA regulator RecX","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-258 are 60% similar to gi15901729 from S.pneumoniae and are 56% similar to gi15675489 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0412 (1e-83).","

InterPro
IPR003783
Family

Regulatory protein RecX
PF02631	$\"[80-206]T$	RecX

InterPro
IPR013822
Domain

GTP-binding signal recognition particle SRP54, helical bundle
SSF47364	$\"[68-122]T$	SRP54

","BeTs to 5 clades of COG2137COG name: Uncharacterized protein RecXFunctional Class: RThe phylogenetic pattern of COG2137 is ------v-ebrh-----l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 182-256 are 41% similar to a (PROTEOME COMPLETE YFHG BH0924) protein domain (PD098633) which is seen in Q9CDN7_LACLA.Residues 48-178 are 36% similar to a (REGULATORY PROTEOME COMPLETE BH0924) protein domain (PD013331) which is seen in Q9CDN7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:46:53 2002","Wed Aug 23 17:27:24 2006","Wed Aug 23 17:27:00 2006","Tue Oct 8 16:46:53 2002","","Fri Mar 1 17:37:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1620 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:46:53 2002","","No significant hits to the NCBI PDB database.","SMU.1780","","Residues 80 to 206 (E-value = 6.7e-07) place SMu1620 in the RecX family which is described as RecX family (PF02631)","Fri Mar 1 17:37:28 2002","24380146","","","","","","1","","","SMU.1780","532" "SMu1621","1682245","1682778","534","ATGAAATTACCTAAGGAAGGCGACTTTATTACAATTCAAAGTTATAAGCATGATGGTAGTTTGCACCGAACTTGGCGCGACACTATGGTACTAAAAACAACAGAAAATGCCGTTATTGGTGTTAATGATCATACGCTAGTCACTGAAAGTGATGGGAGACGATGGGTAACCCGCGAACCAGCTATTGTTTACTTTCATAAAAAATTCTGGTTTAATATCATCGCAATGATTCGAGATAATGGCGTTTCTTACTATTGCAACTTAGCTAGTCCTTATATAATGGATCAAGAAGCATTAAAGTATATCGATTATGATTTAGATGTTAAGGTTTTTGCAGATGGTGAAAAAAAACTTCTAGATGTTGATGAATATGAGTTACATAAACAAAAAATGGGATATTCTTCTGATATTGACTACATTTTGAAAGAAAACGTCAAAATTTTAGTAGACTGGATTAATAATGGTAAAGGACCCTTTTCACAATCCTATATCAATATTTGGTACAAACGTTATCTTGAACTTAAGAATCGTTAA","7.10","0.15","20990","MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAVIGVNDHTLVTESDGRRWVTREPAIVYFHKKFWFNIIAMIRDNGVSYYCNLASPYIMDQEALKYIDYDLDVKVFADGEKKLLDVDEYELHKQKMGYSSDIDYILKENVKILVDWINNGKGPFSQSYINIWYKRYLELKNR","1682788","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-177 are 90% similar to gi|15675490 from S.pyogenes and 87% similar to gi|15901730 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0411 (2e-94).","

InterPro
IPR007295
Family

Protein of unknown function DUF402
PF04167	$\"[37-134]T$	DUF402

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-81 are 90% similar to a (PROTEOME COMPLETE YJJG BH0940) protein domain (PD069731) which is seen in Q9CGX3_LACLA.Residues 82-175 are 76% similar to a (PROTEOME COMPLETE YJJG UU423) protein domain (PD348906) which is seen in Q9CGX3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:45:46 2002","Mon Mar 4 16:05:33 2002","Tue Oct 8 16:45:46 2002","Mon Mar 4 16:05:33 2002","","Mon Mar 4 16:05:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1621 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:45:46 2002","","No significant hits to the NCBI PDB database.","SMU.1781","","Residues 37 to 134 (E-value = 6.9e-39) place SMu1621 in the DUF402 family which is described as Protein of unknown function (DUF402) (PF04167)","Mon Mar 4 16:05:33 2002","24380147","","","","","","1","","","SMU.1781","531" "SMu1622","1682838","1683158","321","ATGGCCTTTACAAATACAAAGGGACGGTATGCAAGTTTTGGTGTGGTAACAAGTTTACCTCCCGAATTGATTGATGTTTTTTGGGAAATTCTTGATAATAACTTAAAAGACGTTTTCACACTTGACACTCTTTTAACCTTTCAATTAGTGAATAATCAAGGGCAACTGAGTTTTAAGTACTACGATAAATACAGTAAAACCGTTATTGTATCTGACTATGCAACCAAATTTGACCCTTTCTATCCAGAAATCGTTCAAATTATTGATAATAATGGCAGAGAAACTATTATTCTCCCTTATGAATTGGACATAGATTTGTAA","4.10","-7.01","12269","MAFTNTKGRYASFGVVTSLPPELIDVFWEILDNNLKDVFTLDTLLTFQLVNNQGQLSFKYYDKYSKTVIVSDYATKFDPFYPEIVQIIDNNGRETIILPYELDIDL","1683168","","conserved hypothetical protein","Cytoplasm, Extracellular","Limited matches to hypothetical proteins. Residues 1-104 are 52% similar to gi|15902314 from S.pneumoniae. Residues 1-102 are 46% similar to gi|15674169 from L.lactis.SMu1622 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-102 are 46% similar to a (PROTEOME COMPLETE) protein domain (PD394151) which is seen in Q9CDN2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:45:08 2002","Mon Mar 4 16:10:19 2002","Tue Oct 8 16:45:08 2002","Mon Mar 4 16:10:19 2002","","Mon Mar 4 16:10:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1622 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:45:08 2002","","No significant hits to the NCBI PDB database.","SMU.1782","","No significant hits to the Pfam 11.0 database","Mon Mar 4 16:10:19 2002","24380148","","","","","","1","","","SMU.1782","" "SMu1623","1691255","1689405","1851","ATGAAACAAAGTAATATGTTAATCCCCACCTTGCGCGAAATGCCAAGTGATGCACAAGTCATCAGTCATGCCCTTATGGTGCGTGCTGGTTATGTCCGCCAAGTATCGGCAGGGATTTACTCTTATTTACCTTTAGCTCATCGCGTTATTGAAAAAATTAAAAAAATCATGCGTGAAGAATTTGATAAAATTGGTGCTGTTGAAATGCTGGCACCTGCCCTTTTAACAGCTGACTTATGGCGTGAATCCGGCCGATATGGAACTTATGGGGAAGATCTTTATAAGTTAAAAAATCGCGATCAATCAGATTTTATTTTAGGGCCGACTCATGAAGAAACTTTTACAAATCTCATCCGTGATGCAGTGAAATCTTACAAGCAGCTTCCCTTGAATCTTTATCAAATTCAAGCAAAATATCGTGACGAAAAACGCCCTCGCAATGGCTTGCTTCGTACTCGTGAATTTATTATGAAAGATGGCTATAGTTTTCATGCTGATTATGACAGTTTAGATGCTACTTATGAAGATTATCGTAAGGCTTATGAAGCCATTTTTACTAGAGTTGGTTTAGATTTTAAAGCGATTATTGGTGATGGCGGTGCTATGGGTGGTAAAGATAGTCAGGAATTTATGGCAGTAACGCCAGATCGTACAGATTTGGAGCATTGGCTGGTTCTTGATAAAGCTATTGGCTCTATTGAAGAGATTCCAGCTGATGTTTTGAAAGAGATTAAACAAGAACTCTCCTCTTGGTTAATATCAGGCGAGGATACTATTGCTTATTCAAGTGAGTCTGATTATGCGGCTAATCTGGAAATGGCGACGAGCGAATATAAGCCTAACAATAAGGTTGTTTCTCATGAAGATATACAGCGTATTGAAACACCAAATTGTAAAACGATTGATGAAGTTGCTGCCTTTTTAGAAATAGATCCAACACAAACCATAAAAACCTTGTTATTTATTGCAGATGATGAACCAGTTGTTGCTTTACTTGTAGGAAATGATCAGGTTAATGAAGTTAAACTAAAAAACTATCTGGGTGCTGACTTCTTGGAACCAGCTAATGAAGAAGAAGCAAGAGAAATTTTTAGTGCTTCCTTTGGTTCTCTAGGTCCAGTTAATCTACCAGAAAATGTCAAAATTGTGGCAGATCGTAAGGTGAAAAATATTGGGAATGCCGTTGTTGGTGCTAATGAAGATGGTTATCATTTGACAGGTGTCAATCCGGAACGTGACTTTGAAGCTGCTTATGTTGATATTCGTGAAGTCTGTGAAGGAGAGGCATCTCCAGATGGTAGGGGTGTTCTTAAATTTGCGCGTGGTATTGAAATTGGTCACATTTTTAAATTGGGAACACGTTATTCAGAAAGTATGGGAGCTAACATTCTTGATGAAAATGGACGTTCAATCCCTATTATTATGGGAAGTTATGGCATCGGTGTTAGTAGAATTCTATCAGCAGTCATTGAACAAAATGCACGTATCTTTGTTAATAAGACACCTAAAGGAGCTTACCGATTTTCTTGGGGAGTTAATTTTCCTAAAACGTTGGCGCCATTTGATGTCCATCTCATTACGGTTAATGTAAAGGATGAAGTCTCCCAACAATTGACAGCAAAAGTAGAAGAAAGTTTGGTAGATGCTCACTATTCTGTTTTAACAGATAATCGGAATGAGCGTATTGGTTCGAAATTTTCTGATAGTGACCTTATTGGGCTGCCGATTCGTGTAACAGTTGGTAAAAAAGCTTCAGATGGTATTGTAGAAGTTAAAATAAAATCGACTGGAGATACAATTGAAGTCAATGCAGAGAACCTATTAGAAACTTTATCTATTTTGATAGACTAG","4.80","-23.60","68678","MKQSNMLIPTLREMPSDAQVISHALMVRAGYVRQVSAGIYSYLPLAHRVIEKIKKIMREEFDKIGAVEMLAPALLTADLWRESGRYGTYGEDLYKLKNRDQSDFILGPTHEETFTNLIRDAVKSYKQLPLNLYQIQAKYRDEKRPRNGLLRTREFIMKDGYSFHADYDSLDATYEDYRKAYEAIFTRVGLDFKAIIGDGGAMGGKDSQEFMAVTPDRTDLEHWLVLDKAIGSIEEIPADVLKEIKQELSSWLISGEDTIAYSSESDYAANLEMATSEYKPNNKVVSHEDIQRIETPNCKTIDEVAAFLEIDPTQTIKTLLFIADDEPVVALLVGNDQVNEVKLKNYLGADFLEPANEEEAREIFSASFGSLGPVNLPENVKIVADRKVKNIGNAVVGANEDGYHLTGVNPERDFEAAYVDIREVCEGEASPDGRGVLKFARGIEIGHIFKLGTRYSESMGANILDENGRSIPIIMGSYGIGVSRILSAVIEQNARIFVNKTPKGAYRFSWGVNFPKTLAPFDVHLITVNVKDEVSQQLTAKVEESLVDAHYSVLTDNRNERIGSKFSDSDLIGLPIRVTVGKKASDGIVEVKIKSTGDTIEVNAENLLETLSILID","1689421","For other 'pro' genes see SMu1792 (proC); SMu1003 (proV);SMu0407 (proB) and SMu0408 (proA) . ","prolyl-tRNA synthetase","Cytoplasm","Matches in gapped BLAST to pro-tRNA synthetases. Residues 1-614 are 80% similar to gi|15675760 from S.pyogenes and 78% similar to gi|15902287 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1913 (0.0).","

InterPro
IPR002314
Domain

tRNA synthetase, class II (G, H, P and S)
PF00587	$\"[49-219]T$	tRNA-synt_2b

InterPro
IPR002316
Family

Prolyl-tRNA synthetase, class IIa
PR01046	$\"[68-86]T$ $\"[104-115]T$ $\"[134-142]T$ $\"[144-155]T$	TRNASYNTHPRO

InterPro
IPR004154
Domain

Anticodon-binding
G3DSA:3.40.50.800	$\"[516-616]T$	Anticodon_bd
PF03129	$\"[522-614]T$	HGTP_anticodon
SSF52954	$\"[510-616]T$	Anticodon_bd

InterPro
IPR004500
Family

Prolyl-tRNA synthetase, bacterial
TIGR00409	$\"[1-614]T$	proS_fam_II

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[33-502]T$	AA_TRNA_LIGASE_II

InterPro
IPR007214
Domain

YbaK/prolyl-tRNA synthetase associated region
PF04073	$\"[287-421]T$	YbaK

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[5-493]T$	G3DSA:3.30.930.10
PTHR11451	$\"[38-215]T$ $\"[254-291]T$ $\"[366-615]T$	PTHR11451
PTHR11451:SF3	$\"[38-215]T$ $\"[254-291]T$ $\"[366-615]T$	PTHR11451:SF3
SSF55681	$\"[9-525]T$	SSF55681
SSF55826	$\"[256-424]T$	SSF55826

","BeTs to 15 clades of COG0442COG name: Prolyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0442 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 514-608 are 61% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000606) which is seen in Q9CDT4_LACLA.Residues 26-103 are 84% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD004144) which is seen in Q9CDT4_LACLA.Residues 48-224 are 25% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD003933) which is seen in Q9CEX2_LACLA.Residues 470-513 are 63% similar to a (SYNTHETASE PROTEOME COMPLETE PROLYL-TRNA) protein domain (PD376032) which is seen in Q9CDT4_LACLA.Residues 254-469 are 64% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD006954) which is seen in Q9CDT4_LACLA.Residues 187-253 are 70% similar to a (SYNTHETASE PROTEOME COMPLETE PROLYL-TRNA) protein domain (PD387438) which is seen in Q9CDT4_LACLA.Residues 104-185 are 75% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000380) which is seen in Q9CDT4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 11:23:48 2002","Mon Mar 4 16:33:01 2002","Tue Oct 15 11:23:48 2002","Tue Apr 9 15:03:46 2002","","Mon Mar 4 16:33:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1623 is paralogously related (blast p-value < 1e-3) to SMu1441, a predicted threonyl, and to SMu1714, a predicted seryl tRNA synthetase.","Mon Mar 4 19:07:01 2002","","No significant hits to the NCBI PDB database.","SMU.1783c","","Residues 38 to 192 (E-value = 7.2e-52) place SMu1623 in the tRNA-synt_2b family which is described as tRNA synthetase class II core domain (G, H, P, S and T) (PF00587)Residues 287 to 421 (E-value = 5.7e-34) place SMu1623 in the YbaK family which is described as YbaK / prolyl-tRNA synthetases associated domain (PF04073)Residues 522 to 614 (E-value = 7e-18) place SMu1623 in the HGTP_anticodon family which is described as Anticodon binding domain (PF03129)","Mon Mar 4 16:33:01 2002","","","","","Mon Mar 4 19:04:22 2002","","1","","","SMU.1783c","190" "SMu1624","1692541","1691282","1260","ATGTCAGGACTAATAGCTTTTATTATTATCTTTGGAATTATAGTTCTTGTCCATGAATTTGGTCATTTCTATTTTGCTAGAAAATCAGGAATTTTGGTTCGGGAATTTGCCATTGGTATGGGACCGAAAATTTTTGCACATCAAGGAAAAGACGGTACAGCTTATACCATTCGAATTTTGCCTTTAGGTGGCTATGTCCGTATGGCTGGCTGGGGAGAAGATACTAGCGAAATTAAAACAGGGATACCTGCCGCTTTGACGCTTAATAAAGCAGGTGTGGTCACTCGTATTGACCTTTCTGACAGGCAAGTGGACAAGACGGCCTTGCCTATAAATGTGACAGCTTATGATTTAGAAGACAAATTAGAGATTACAGGACGCGTTCTTGAAGAAACTAAGACTTATCCAGTGGATCATGATGCAACAATTGTTGAAGAGGATGGAACAGAAATTCGCATTGCACCGCTAGATGTGCAATATCAAAAGGCTAGTATTTGGGGACGTTTAATCACTAATTTTGCAGGTCCCATGAATAACTTTATTTTAGGTATTTTTGTTTTTGCCCTCTTGATTTTTGTGCAAGGCGGTGTTCAGGATTCTTCAAGCAATCATGTGCGTGTGACTCCTAACAGTGCTGTAGCTAAGCTCGGACTTAAGAATAATGATCAAATTTTACAAATTGGGAAAAACAAAGTTCATAATTGGAATGATCTCACTAATGCGGTTGCTAAGTCAACTAGTAATTTGAAAAAGAAAGAAGCTATTCCAGTTAAGGCTAAGACTCAAGGAAGCGTAAAAACTTTAAAAGTCATCCCTAAAAAAGTTAATGGGAATTACGTTATTGGTGTCATGCCAAGTATGAAAACAGGATTTGGGGATAAAATTGTTGGTGCCTTTAAGATGTCTTGGGACGGCGCTTTTGTTATCTTGAATGGTCTTAAAGGGCTAATCCTACAGCCAAGTCTCAATAAATTAGGTGGTCCTGTTGCGATTTATCAACTGAGTAATACAGCTGCTAGAGAAGGTTTTGCAAGAGTCCTTGAATTAATGGCTATGCTTTCTATTAATCTGGGTATTTTTAATTTGTTGCCTATTCCTGCTCTTGATGGTGGTAAAATTTTAATCAATTTTATAGAAGTTATTCGAAAAAAACCGCTCAAACAAGAGACAGAAACCTATATTACCCTCGCTGGTGTTCTTATTATGGTTGCGCTTATGATTGCAGTAACTTGGAATGATATCATGCGAGCATTTTTCTAA","10.30","12.45","45769","MSGLIAFIIIFGIIVLVHEFGHFYFARKSGILVREFAIGMGPKIFAHQGKDGTAYTIRILPLGGYVRMAGWGEDTSEIKTGIPAALTLNKAGVVTRIDLSDRQVDKTALPINVTAYDLEDKLEITGRVLEETKTYPVDHDATIVEEDGTEIRIAPLDVQYQKASIWGRLITNFAGPMNNFILGIFVFALLIFVQGGVQDSSSNHVRVTPNSAVAKLGLKNNDQILQIGKNKVHNWNDLTNAVAKSTSNLKKKEAIPVKAKTQGSVKTLKVIPKKVNGNYVIGVMPSMKTGFGDKIVGAFKMSWDGAFVILNGLKGLILQPSLNKLGGPVAIYQLSNTAAREGFARVLELMAMLSINLGIFNLLPIPALDGGKILINFIEVIRKKPLKQETETYITLAGVLIMVALMIAVTWNDIMRAFF","1691298","","conserved hypothetical protein, peptidase family M50","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to pheromone-related protein, Eep proteins and hypotheticals. Residues 18-419 are 63% similar to >gi15900197, a predicted eep protein, in S.pneumoniae and 50% similar to gi5714510 in E.faecalis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1914 (1e-169).","

InterPro
IPR001478
Domain

PDZ/DHR/GLGF
SSF50156	$\"[174-277]T$	PDZ

InterPro
IPR004387
Family

Peptidase M50, putative membrane-associated zinc metallopeptidase
TIGR00054	$\"[1-419]T$	Pept_M50_Zn

InterPro
IPR006025
Binding_site

Peptidase M, neutral zinc metallopeptidases, zinc-binding site
PS00142	$\"[15-24]?$	ZINC_PROTEASE

InterPro
IPR008915
Family

Peptidase M50
PF02163	$\"[6-413]T$	Peptidase_M50

noIPR
unintegrated

unintegrated
G3DSA:2.30.42.10	$\"[205-276]T$	G3DSA:2.30.42.10

","BeTs to 13 clades of COG0750COG name: Predicted membrane-associated Zn-dependent proteases 1Functional Class: MThe phylogenetic pattern of COG0750 is AmtK-qvCebrhUj--olinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 18-85 are 73% similar to a (COMPLETE PROTEOME PROTEASE) protein domain (PD004820) which is seen in Q9CDT3_LACLA.Residues 346-409 are 60% similar to a (COMPLETE PROTEOME PROTEASE TRANSMEMBRANE) protein domain (PD005718) which is seen in Q9CDT3_LACLA.Residues 91-173 are 54% similar to a (PROTEOME COMPLETE YVJB YLUC) protein domain (PD081337) which is seen in Q9CDT3_LACLA.Residues 175-274 are 38% similar to a (PROTEOME COMPLETE PROTEASE TRANSMEMBRANE) protein domain (PD015674) which is seen in Q9RPP2_ENTFA.Residues 281-340 are 60% similar to a (PROTEOME COMPLETE YVJB EEP) protein domain (PD412567) which is seen in Q9CDT3_LACLA.Residues 343-416 are 45% similar to a (COMPLETE PROTEOME LPXA FABZ) protein domain (PD395252) which is seen in O67776_AQUAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 4 19:14:41 2002","Tue Sep 19 16:12:13 2006","Tue Sep 19 16:12:13 2006","Thu Apr 11 09:12:13 2002","","Mon Mar 4 19:08:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1624 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 4 19:14:41 2002","","No significant hits to the NCBI PDB database.","SMU.1784c","","Residues 6 to 413 (E-value = 2.4e-79) place SMu1624 in the Peptidase_M50 family which is described as Peptidase family M50 (PF02163)","Mon Mar 4 19:08:49 2002","24380150","","","","","","1","","","SMU.1784c","484" "SMu1625","1693351","1692557","795","ATGCAGAAACGTGTTCTTTTTGGGGGAGTGGCTCTGGCTATTTTTCTCCCTTTCCTATTTTTGGGAGGTCTCTTTTTTCAGCTTTTTGTTGGTGTTCTAGCCATGATTGGCGTATCTGAACTGTTGAAAATGAAGGCGTTAGAAATTTTTTCATTTGAAGGTATTTTAGCTATGCTTGCGGCTTTTGTGCTGACTATTCCTTTAGAGAACTACCTGACTTTTTTACCGATTGATGGCAGCTTTAGTGCTTTTGGTCTCGTTATCTTTTTGATTTTAGCAGGAACGGTCTTAAATACTAATCGCTATTCTTTCGAAGATGCTGCTTTTCCTATTGCTTCCAGTCTTTATGTTGGGATTGGTTTTCAAAATCTCGTTAATGCTCGCATTTCTGGACTTGATAAAGTTTTTCTAGCCCTTTTTATCGTTTGGGCGACTGATATTGGAGCTTATATGATTGGTCGGCAGTTTGGTCAACGTAAATTGATGCCGGCAGTTTCTCCTAACAAGACTATTGAAGGCAGCTTAGGAGGAATTTTGTCGGCAGTTGTCATTGCTTTTATCTTTATGTTGTTTGATAAGAATGTTTACGCACCGCATCACTTCTTAGTCATGCTTATTTTGGTTGCTCTCTTTAGTATCTTTGCCCAATTTGGTGATCTAGTTGAAAGTTCAATTAAACGACATTTTGGTGTTAAGGATTCTGGCAAACTCATACCGGGGCACGGAGGTATTTTAGACCGTTTTGACAGTATGATTTTTGTTTTTCCAATCATGCACTTCTTTGGTTTGTTCTAA","9.10","2.19","29022","MQKRVLFGGVALAIFLPFLFLGGLFFQLFVGVLAMIGVSELLKMKALEIFSFEGILAMLAAFVLTIPLENYLTFLPIDGSFSAFGLVIFLILAGTVLNTNRYSFEDAAFPIASSLYVGIGFQNLVNARISGLDKVFLALFIVWATDIGAYMIGRQFGQRKLMPAVSPNKTIEGSLGGILSAVVIAFIFMLFDKNVYAPHHFLVMLILVALFSIFAQFGDLVESSIKRHFGVKDSGKLIPGHGGILDRFDSMIFVFPIMHFFGLF","1692573","","phosphatidate cytidylyltransferase (CDP-diglyceride synthase)","Membrane, Cytoplasm","Matches in gapped BLAST to phosphatidate cytidylyltransferases. Residues 1-264 are 71% similar to gi|15675762 from S.pyogenes and 54% similar to gi|15900196 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1915 (1e-113).","

InterPro
IPR000374
Family

Phosphatidate cytidylyltransferase
PF01148	$\"[2-264]T$	CTP_transf_1
PS01315	$\"[223-249]T$	CDS

noIPR
unintegrated

unintegrated
PD002096	$\"[198-244]T$	PD002096
PTHR13773	$\"[206-249]T$	PTHR13773

","BeTs to 15 clades of COG0575COG name: CDP-diglyceride synthetaseFunctional Class: IThe phylogenetic pattern of COG0575 is amtkyqvcEbrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000374 (Phosphatidate cytidylyltransferase) with a combined E-value of 3.2e-30. IPB000374A 165-177 IPB000374B 223-250","Residues 169-254 are 53% similar to a (CYTIDYLYLTRANSFERASE COMPLETE PROTEOME) protein domain (PD016601) which is seen in CDSA_BACSU.Residues 168-259 are 63% similar to a (CYTIDYLYLTRANSFERASE SYNTHASE CDP-DIGLYCERIDE SYNTHETASE) protein domain (PD334873) which is seen in Q9CDT2_LACLA.Residues 43-167 are 32% similar to a (CYTIDYLYLTRANSFERASE PHOSPHATIDATE) protein domain (PD167880) which is seen in CDSA_BACSU.Residues 35-94 are 43% similar to a (PROTEOME CYTIDYLYLTRANSFERASE COMPLETE) protein domain (PD393269) which is seen in Q9CDT2_LACLA.Residues 96-167 are 60% similar to a (CYTIDYLYLTRANSFERASE PHOSPHATIDATE) protein domain (PD120205) which is seen in Q9CDT2_LACLA.Residues 86-189 are 28% similar to a (CYTIDYLYLTRANSFERASE SYNTHASE CDP-DIGLYCERIDE SYNTHETASE) protein domain (PD002096) which is seen in Q9PPX8_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 4 19:26:06 2002","Mon Mar 4 19:16:49 2002","Wed Oct 16 11:39:52 2002","Wed Oct 16 11:39:52 2002","Mon Mar 4 19:16:49 2002","Mon Mar 4 19:16:49 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1625 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 4 19:26:06 2002","","No significant hits to the NCBI PDB database.","SMU.1785c","","Residues 2 to 264 (E-value = 4.4e-96) place SMu1625 in the CTP_transf_1 family which is described as Cytidylyltransferase family (PF01148)","Mon Mar 4 19:16:49 2002","","","","Weber CH, Park YS, Sanker S, Kent C, Ludwig ML.A prototypical cytidylyltransferase: CTP:glycerol-3-phosphate cytidylyltransferase from bacillus subtilis.Structure Fold Des. 1999 Sep 15;7(9):1113-24.PMID: 10508782Gaillard JL, Lubochinsky B, Rigomier D.Specific inhibition of phosphatidate cytidylyltransferase from Bacillus subtilis membranes by cytidine monophosphate.Biochim Biophys Acta. 1983 Oct 11;753(3):372-80.PMID: 6311276 ","","Mon Mar 4 19:26:06 2002","1","","","SMU.1785c","485" "SMu1626","1694115","1693366","750","ATGTTTACATTAAGACGAAAAAAACAAGATATAAAATTATCTAAAATCCCAGCTCATATCGGTATCATTATGGATGGCAATGGACGCTGGGCTAAGAAACGAATGAAACCAAGGGTATTTGGACATAAGGCTGGTATGGATGCCCTTCAAGATGTGACGATAGCGGCATCGGAACTTGGAGTCAAAATTTTAACAGTTTATGCTTTTTCAACGGAAAATTGGGCTCGTCCTCAAGAAGAGGTTAAATTTATCATGAATTTACCTGTAGAGTTCTTTGATAAGTATGTTCCTAAGCTGCATAAAAATAATGTTCGTATTTTAGTGATTGGCGATAAGGAAGAACTGCCGGCAGCAACTTTAGATGCTCTGGAACGCGCTAGAGAACTGACTAAACATAATTCTGGACTTATTTTAAATTTTGCTTTGAATTATGGCGGTCGTGCTGAAATTGTTGATGCTGTAAAGTTGATTGCTCAAGATGTTTTAGATGCTCGGTTTAACCCTGGTGATATTACAGAAGGGCTCATTGCTGATTACTTGATGACAAGCAATCTTCCTTACCTTTACCGTGATCCCGATTTGATTATTAGAACGAGTGGTGAGCTGCGTCTTAGTAACTTTTTACCGTGGCAGGCTGCTTATAGTGAGCTTTATTTTACAGATACACTTTGGCCAGATTTTGATAAAAAAGCTTTGTATTTAGCTATTGAAGAATTTAACCATCGCCATCGTCGCTTTGGTGGTGTTTAG","9.70","4.45","28510","MFTLRRKKQDIKLSKIPAHIGIIMDGNGRWAKKRMKPRVFGHKAGMDALQDVTIAASELGVKILTVYAFSTENWARPQEEVKFIMNLPVEFFDKYVPKLHKNNVRILVIGDKEELPAATLDALERARELTKHNSGLILNFALNYGGRAEIVDAVKLIAQDVLDARFNPGDITEGLIADYLMTSNLPYLYRDPDLIIRTSGELRLSNFLPWQAAYSELYFTDTLWPDFDKKALYLAIEEFNHRHRRFGGV","1693382","For other 'upp' genes see SMu1525 (upp). ","undecaprenyl pyrophosphate synthetase","Cytoplasm, Extracellular","Matches in gapped BLAST to undecaprenyl pyrophosphate synthetases. Residues 1-249 are 74% similar to gi15675763 from S.pyogenes and are 71% similar to gi15902284 from S.pneumoniae. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1916 (1e-110).","

InterPro
IPR001441
Family

Di-trans-poly-cis-decaprenylcistransferase
PD003461	$\"[19-242]T$	UPP_synth
G3DSA:3.40.1180.10	$\"[11-247]T$	UPP_synth
PTHR10291	$\"[1-248]T$	UPP_synth
PF01255	$\"[23-248]T$	Prenyltransf
TIGR00055	$\"[16-247]T$	uppS
PS01066	$\"[193-210]T$	UPP_SYNTHETASE
SSF64005	$\"[10-242]T$	UPP_synth

","BeTs to 16 clades of COG0020COG name: Undecaprenyl pyrophosphate synthaseFunctional Class: IThe phylogenetic pattern of COG0020 is AmtkYqvcebRhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001441 (Undecaprenyl pyrophosphate synthetase family) with a combined E-value of 3.5e-83. IPB001441A 17-31 IPB001441B 60-87 IPB001441C 130-157 IPB001441D 190-227","Residues 23-248 are 57% similar to a (UNDECAPRENYL SYNTHETASE CELL) protein domain (PD003461) which is seen in Q9CDT1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 16:18:46 2006","Mon Mar 4 19:28:00 2002","Tue Sep 19 16:18:10 2006","Thu Apr 11 11:12:08 2002","Mon Mar 4 19:28:00 2002","Mon Mar 4 19:28:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1626 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 4 19:31:39 2002","","No significant hits to the NCBI PDB database.","SMU.1786c","","Residues 23 to 248 (E-value = 7.3e-111) place SMu1626 in the UPP_synthetase family which is described as Putative undecaprenyl diphosphate synthase (PF01255)","Mon Mar 4 19:28:00 2002","","","","Apfel CM, Takacs B, Fountoulakis M, Stieger M, Keck W.Use of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: cloning, expression, and characterization of the essential uppS gene.J Bacteriol. 1999 Jan;181(2):483-92.PMID: 9882662","","Mon Mar 4 19:35:09 2002","1","","","SMU.1786c","486" "SMu1627","1694610","1694227","384","ATGTCTTATACTACAATTATCATGTTTGTTGTTTTGATTGGAGCCATTTTTTTGATGCAGCGTTCCCAAAAGAAACAAGCTCAAGAGCGGCAAAATCAATTAAATGCTATTGCTAAAGGAGATGAAGTTGTCACCATTGGCGGTATGTACGCTGTTGTTGATGAAGTGGACAATGATAATAAAAAGATTGTTCTTGACGTTGACGGTGTCTTCTTGCCTTTTGAACTAACGGCAATTAAGCGCGTTGTAACAAAAGAAAGTCAGACTGTAGAAACTGATCAAACGCCGGAAGAAGCAACTGAAATTATTGAAACTTCAAAAATAGAAGAAAAAGGTTCAGATTCTAAGGAAACAGCAAGTACTGAATCTGCCATTGAAGAATAA","4.20","-10.99","14072","MSYTTIIMFVVLIGAIFLMQRSQKKQAQERQNQLNAIAKGDEVVTIGGMYAVVDEVDNDNKKIVLDVDGVFLPFELTAIKRVVTKESQTVETDQTPEEATEIIETSKIEEKGSDSKETASTESAIEE","1694243","","preprotein translocase, YajC subunit","Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypothetical proteins and secreted proteins. Residues 1-95 are 71% similar to gi15675764 from S.pyogenes. Residues 1-96 are 43% similar to >gi15674113 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1917 (1e-27).","

InterPro
IPR003849
Family

YajC
PD374630	$\"[6-80]T$	YajC
PF02699	$\"[1-83]T$	YajC
TIGR00739	$\"[1-84]T$	yajC

","BeTs to 8 clades of COG1862COG name: Uncharacterized secreted proteins, YajC familyFunctional Class: SThe phylogenetic pattern of COG1862 is -----qv-ebrhuj--o-inxNumber of proteins in this genome belonging to this COG is 1","***** IPB003849 (Domain of unknown function DUF219) with a combined E-value of 2.9e-14. IPB003849 14-49","Residues 6-80 are 44% similar to a (TRANSMEMBRANE COMPLETE PROTEOME YAJC) protein domain (PD010508) which is seen in Q47777_ENTFA.Residues 2-86 are 45% similar to a (PRECURSOR SIGNAL SECRETED ML0486) protein domain (PD407220) which is seen in Q9L292_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:43:56 2002","Mon Sep 4 14:14:33 2006","Mon Sep 4 14:14:33 2006","Tue Oct 8 16:43:56 2002","Tue Mar 5 07:30:09 2002","Tue Mar 5 07:30:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1627 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:43:56 2002","","No significant hits to the NCBI PDB database.","SMU.1787c","","Residues 1 to 83 (E-value = 2.3e-10) place SMu1627 in the YajC family which is described as Preprotein translocase subunit (PF02699)","Tue Mar 5 07:30:09 2002","24380153","","","","","","1","","","SMU.1787c","1023" "SMu1628","1695132","1694785","348","ATGTCACATTTTACAGAAGCGATTAAACATTTTAACGCTCTAACAGCACAAGAAGCACAGGAAAAAATTGATAGTGGAGAAAAGTTTATTCTTTTCATTGGACGTTCAACTTGTCCTTACTGTCAGCGTTTTGCTCCTAAGTTGAGTCAGGTTGCTGCAGATACGGGTCAGACAGTCGCTTTTTTAAATAGTGAAAATCAAGATGATTTAACAGCTGTTCAAGCTTTCCGTGAGAAATATCATGTTCAGACAGTACCGGGGCTTTTAGTTGCTCAAGCAGGACAAGTCAAAGTTGTTTGTGATTCATCGCTTTCACAAGAGGCTATTGCTGATTTTATCGCTCAATAG","5.20","-3.43","12592","MSHFTEAIKHFNALTAQEAQEKIDSGEKFILFIGRSTCPYCQRFAPKLSQVAADTGQTVAFLNSENQDDLTAVQAFREKYHVQTVPGLLVAQAGQVKVVCDSSLSQEAIADFIAQ","1694801","","bacterocin transport accessory protein","Cytoplasm, Extracellular","Matches in gapped BLAST to hypothetical proteins and Bta proteins. Residues 4-91 are 57% similar to gi14973539 from S.pyogenes. Residues 1-112 are 45% similar to a predicted Bta protein from S.pneumoniae (gi5929888).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1918 (1e-24).","

InterPro
IPR006662
Domain

Thioredoxin-related
PR00421	$\"[37-46]T$ $\"[81-92]T$	THIOREDOXIN

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[9-115]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[4-115]T$	IPR012336

","BeTs to 6 clades of COG0526COG name: Thiol-disulfide isomerase and thioredoxinsFunctional Class: O,CThe phylogenetic pattern of COG0526 is AMTkYQVCEBRHUJgpoLINXNumber of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 4-65 are 46% similar to a (ACCESSORY BTA TRANSPORT) protein domain (PD412736) which is seen in Q9RP93_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 07:37:25 2002","Thu Sep 21 07:59:27 2006","Thu Sep 21 07:59:27 2006","Wed Oct 16 11:38:19 2002","","Tue Mar 5 07:31:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1628 is paralogously related (blast p-value < 1e-3) to SMu1729, a hypothetical.","Tue Mar 5 07:38:17 2002","","No significant hits to the NCBI PDB database.","SMU.1788c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 07:31:00 2002","24380154","","Hardy,G.G., Caimano,M.J. and Yother,J.Capsule biosynthesis and basic metabolism in Streptococcuspneumoniae are linked through the cellular phosphoglucomutaseJ. Bacteriol. 182 (7), 1854-1863 (2000)PubMed: 20179798","","Tue Mar 5 07:37:25 2002","","1","","","SMU.1788c","980" "SMu1629","1696041","1695325","717","ATGGGACGTAAATGGGCTAATATTGTCGCTAAAAAAACTGCTAAAGACGGTGCAAACTCTAAAGTTTATGCTAAGTTTGGTGTCGAAATCTATGTGGCTGCCAAGCAAGGGGAGCCAGATCCAGAATCAAATTCAGCTTTGAAATTTGTTTTGGAACGTGCTAAACAAGCACAGGTTCCAAAACATGTTATTGATAAGGCTATTGATAAGGCTAAAGGAAATACGGATGAAACTTTCGTGGAAGGTCGTTATGAAGGCTTTGGGCCAAACGGTTCCATGATTATTGTGGATACCTTAACTTCAAATGTTAACCGTACAGCAGCCAATCTTCGGACTGCTTTTGGTAAGAATGGCGGGAATATGGGAGCAGCTGGATCTGTTTCTTATATGTTTGATAAAAAAGGTGTTATTGTCTTTGCAGGTGACGATGCGGACAGTATCTTTGAACAATTGCTTGAGGCTGATATTGATGTTGAAGATGTTGAAGCGGAAGACGGTTCTGTAACAGTTTATACTGCTCCAACAGACCTTCACAGAGGTATTGAAGCGCTTCGTGCTGGCGGTGTTGCAGAATTTCAAGTGACCGAACTTGAAATGATTCCTCAGTCTGAAGTGACACTTGAAGGGGAAGATTTGGAAACCTTTGAAAAACTTATTGATGCTCTTGAAGACGATGACGATGTGCAAAAAGTTTATCACAATGTTGATGGCTTATAA","4.30","-18.25","25726","MGRKWANIVAKKTAKDGANSKVYAKFGVEIYVAAKQGEPDPESNSALKFVLERAKQAQVPKHVIDKAIDKAKGNTDETFVEGRYEGFGPNGSMIIVDTLTSNVNRTAANLRTAFGKNGGNMGAAGSVSYMFDKKGVIVFAGDDADSIFEQLLEADIDVEDVEAEDGSVTVYTAPTDLHRGIEALRAGGVAEFQVTELEMIPQSEVTLEGEDLETFEKLIDALEDDDDVQKVYHNVDGL","1695341","Note tandem repeats at 1695841,1695866.","conserved hypothetical protein","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-235 are 85% similar to gi|15674481 from S.pyogenes. Residues 1-237 are 80% similar to gi|15901746 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1645 (1e-117).","

InterPro
IPR002876
Family

Protein of unknown function DUF28
PD004323	$\"[11-234]T$	DUF28
PTHR12532	$\"[3-236]T$	DUF28
PF01709	$\"[3-236]T$	DUF28
TIGR01033	$\"[1-236]T$	DUF28

InterPro
IPR003308
Domain

Integrase, N-terminal zinc-binding
G3DSA:1.10.10.200	$\"[4-79]T$	Intgrase_N_Zn_bd

noIPR
unintegrated

unintegrated
G3DSA:3.30.1270.10	$\"[80-236]T$	G3DSA:3.30.1270.10
SSF75625	$\"[3-236]T$	SSF75625

","BeTs to 13 clades of COG0217COG name: Uncharacterized ACR, YebC familyFunctional Class: SThe phylogenetic pattern of COG0217 is ----yqvcEBrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002876 (Domain of unknown function DUF28) with a combined E-value of 1.2e-76. IPB002876A 22-73 IPB002876B 84-129 IPB002876C 208-234","Residues 3-235 are 76% similar to a (PROTEOME COMPLETE MG332 CSBX-COXA VMA7-RPS25A TC0742) protein domain (PD004323) which is seen in Q9CIX4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 30 11:28:23 2002","Tue Mar 5 07:41:02 2002","Wed Oct 30 11:28:23 2002","Tue Oct 8 16:43:10 2002","Tue Mar 5 07:41:02 2002","Tue Mar 5 07:41:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1629 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:43:10 2002","","No significant hits to the NCBI PDB database.","SMU.1789c","","Residues 3 to 236 (E-value = 9.4e-133) place SMu1629 in the DUF28 family which is described as Domain of unknown function DUF28 (PF01709)","Tue Mar 5 07:41:02 2002","24380155","","","","","","1","","","SMU.1789c","452" "SMu1630","1696921","1696187","735","ATGAGAGGAGATTCAATCATGAAAACAGTAAAAGAAATGAGCAGGCTGTCAGGTGTTAGTGTGCGCACACTTCATTATTATGATGAAATCAATTTGCTGACACCTAGTTTTATTGCCAATAATGGCTATCGCTATTATGATGATAAAGCCTTTGAGCGCTTGCAGGAAATTTTGCTTTTTCGTGAACTGGAATTTCCTCTCAAAACAATCAAAGAGATTGTAGGGAATACAGCTTATGACAGGGATTTTGCTTTACAGGAACAAATAAAGCTTTTAGAAATGAAGAAAGCACACCTGGAGAAAGTCATCAAGCATGCTAAATCCCTGCAAGAAAAAGGAGATAGTTATATGAAATTTGATGCTTATGACAAAACGGAGCTGAAAGCTTTACAGGAAGAAGCTAAGCAAAGATGGGGAAAAACTGCGGCTTATCAGAAATTTGCAGCAAAAATATCAGATAAAGATTTTGCTCACATCAGCTCAGAAATGTCTGCTATTATGTCTGCTTTTGGTCGGTTAAAACAATTACCGGTTGACCATGCTGAAGTACAGCAGCAGGTAGAGAGCTTGAGAAACTATATTAGTCAGAATTTTTATGCTTGTAATAAGGATATATTGGCTAGATTGGGCAAAATGTATACTGCGGACAATCGTTTTAGTCAAACGATTGATACTGCAGGCGGTCAGGGAACGGCAGCCTTTGTAGCACAAGCTATCACAGCTTACTGTCGGTAA","9.40","5.12","28006","MRGDSIMKTVKEMSRLSGVSVRTLHYYDEINLLTPSFIANNGYRYYDDKAFERLQEILLFRELEFPLKTIKEIVGNTAYDRDFALQEQIKLLEMKKAHLEKVIKHAKSLQEKGDSYMKFDAYDKTELKALQEEAKQRWGKTAAYQKFAAKISDKDFAHISSEMSAIMSAFGRLKQLPVDHAEVQQQVESLRNYISQNFYACNKDILARLGKMYTADNRFSQTIDTAGGQGTAAFVAQAITAYCR","1696203","","transcriptional regulator, probable MerR family","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Residues 10-243 are 40% similar to gi|15896713 from C.acetobutylicum and 36% similar to gi|16080713 from B.subtilis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1972 (5e-79).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PR00040	$\"[9-20]T$ $\"[20-33]T$ $\"[44-64]T$	HTHMERR
PF00376	$\"[9-46]T$	MerR
SM00422	$\"[9-77]T$	HTH_MERR
PS50937	$\"[7-76]T$	HTH_MERR_2

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[8-121]T$	Putativ_DNA_bind

InterPro
IPR012925
Domain

TipAS antibiotic-recognition
PF07739	$\"[119-243]T$	TipAS

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[6-114]T$	G3DSA:1.10.1660.10
G3DSA:1.10.490.50	$\"[156-243]T$	G3DSA:1.10.490.50
SSF89082	$\"[156-244]T$	SSF89082

","BeTs to 5 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 1.7e-19. IPB000551A 10-31 IPB000551B 33-74","Residues 12-46 are 65% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REGULATOR) protein domain (PD000861) which is seen in SKGA_CAUCR.Residues 48-242 are 33% similar to a (REGULATION TRANSCRIPTION DNA-BINDING) protein domain (PD034841) which is seen in P71039_BACSU.Residues 9-105 are 32% similar to a (REGULATION TRANSCRIPTION MERCURY MERCURIC) protein domain (PD072158) which is seen in O53082_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 07:46:46 2002","Tue Mar 5 07:46:46 2002","Wed Oct 16 11:34:35 2002","Wed Oct 16 11:34:35 2002","Tue Mar 5 07:44:43 2002","Tue Mar 5 07:44:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1630 is paralogously related (blast p-value < 1e-3) to SMu0144, SMu1868, SMu0663, SMu0477, SMu1918, and SMu0619, mostly MerR-related transcriptional regulators.","Tue Mar 5 07:46:46 2002","","No significant hits to the NCBI PDB database.","SMU.1790c","","Residues 9 to 46 (E-value = 1.5e-08) place SMu1630 in the MerR family which is described as MerR family regulatory protein (PF00376)","Tue Mar 5 07:44:43 2002","24380156","","","","","","1","","","SMU.1790c","" "SMu1631","1698107","1697007","1101","ATGACCACAACAGGCATTATCGCAGAATTTAATCCTTTCCACAATGGGCATAAGTATTTGCTGGATCAGGCACATGGGCTGAAGATTGTTGCTATGTCCGGTAATTTCGTCCAGCGCGGCGAGCCTGCCATCATTGATAAGTGGACACGAGCGCAAATGGCGCTGGAAAATGGCGCTGACCTTGTGGTTGAACTGCCTTTTCTGGTTGCTGTCCAGTCGGCCGATTATTTTGCCAGCGGAGCAGTGGATATTTTAGCCAAACTCGGCATTGATACCCTTGCTTTCGGCACAGAAACTGCTCTGGACTATAATGGTTTGTCTACTATTTATGGGAAAATGGCAGAGCAGATGAGTGAATTCCTCACGACGCTGCCTGAGAAGCTCAGCTATCCCCAAAAAACGCAGCTCATGTGGGAAAAATTTGCAGGGGTTCAGTTCACAGGAGACACTCCAAATCATATTCTTGCTTTGGCCTACGCCAAGGCTTGCGCAGGAAGAAATATACGATTACGGCCCATCCAACGGCGAGGTGCAGATTATCATTCTACAGAAAAAACTGTGGCTTACGCTTCCGCGACCAGTTTACGACATCACCGGCAGGATCCAGCCTTTGTGGCTAAAAGCATGCCCAATGCAAACCTTTTTCAAACGAGTCCGCAAGTGACTTGGGAAGACTATTTTACTCTACTTCAGTATCAAGTGTTGACACAACCCGATTTAACCCAGCTTTTCCAAGTCAATGAAGAATTGGCTATCCGCATCAAAAAAGCTATCCGACAAGTCACAAGCTTTGATCAATTAGTAGAAACTGTCGCTACCAAACGCTACACCAAAGCGCGCGTGCGCCGCATCTTAATCTATATCTTAATCGGTGCGCGTGAAACTAGCCTACCGCAGGACGTTCACATCCTTGGTTTCACAGCCGCTGGTCGTACGCACCTATCTCATATTAAAAACAAGACCCGAATCATCTCCCGAATCGGGTCTCAACCGTGGGACGCCCTCACTCAACAAGCAGACCAAGTCTACCAGCTCGGAAATCCAAAAATAGCCGAACAAACATGGGGACGCGTGCCAATTAGAATAGATAACACAGTCTAG","10.00","8.37","41051","MTTTGIIAEFNPFHNGHKYLLDQAHGLKIVAMSGNFVQRGEPAIIDKWTRAQMALENGADLVVELPFLVAVQSADYFASGAVDILAKLGIDTLAFGTETALDYNGLSTIYGKMAEQMSEFLTTLPEKLSYPQKTQLMWEKFAGVQFTGDTPNHILALAYAKACAGRNIRLRPIQRRGADYHSTEKTVAYASATSLRHHRQDPAFVAKSMPNANLFQTSPQVTWEDYFTLLQYQVLTQPDLTQLFQVNEELAIRIKKAIRQVTSFDQLVETVATKRYTKARVRRILIYILIGARETSLPQDVHILGFTAAGRTHLSHIKNKTRIISRIGSQPWDALTQQADQVYQLGNPKIAEQTWGRVPIRIDNTV","1697023","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-363 are 65% similar to gi|15903629 from S.pneumoniae. Residues 1-364 are 61% similar to gi|15674479 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1656 (1e-142).","

InterPro
IPR008513
Family

Protein of unknown function DUF795
PF05636	$\"[1-360]T$	DUF795

noIPR
unintegrated

unintegrated
SSF52374	$\"[10-212]T$	SSF52374

","BeTs to 4 clades of COG1323COG name: Uncharacterized ACR, YlbM familyFunctional Class: SThe phylogenetic pattern of COG1323 is -mt---v--b-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 9-76 are 40% similar to a (PROTEOME COMPLETE MJ0951) protein domain (PD041617) which is seen in Y951_METJA.Residues 4-361 are 53% similar to a (PROTEOME COMPLETE BH2585 YCCL) protein domain (PD139992) which is seen in Q9CIX6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:42:26 2002","Tue Mar 5 07:49:51 2002","Tue Oct 8 16:42:26 2002","Tue Oct 8 16:42:26 2002","","Tue Mar 5 07:49:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1631 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:42:26 2002","","No significant hits to the NCBI PDB database.","SMU.1791c","","Residues 1 to 360 (E-value = 1.9e-188) place SMu1631 in the DUF795 family which is described as Protein of unknown function (DUF795) (PF05636)","Tue Mar 5 07:49:51 2002","24380157","","","","","","1","","","SMU.1791c","453" "SMu1632","1698428","1698255","174","ATGATTTATACAGCCATTGTGGAGCCCACATTTTTAGCTGTGCTGGCCTTGTCTGGTCAAGTCAACAATATCCCCTTATCGCTACTATATAAGCTCATCTGGGTGCTTAAGCCAAAGCCCGCTCTTCTTGTTGATTTTGGCTGTTATGTCCAACAAACACCACCTATTTATTGA","8.40","0.93","6360","MIYTAIVEPTFLAVLALSGQVNNIPLSLLYKLIWVLKPKPALLVDFGCYVQQTPPIY","1698271","","hypothetical protein","Cytoplasm, Extracellular","No significant matches in gapped BLAST to GenBank.SMu1632 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-18]?$	signal-peptide
tmhmm	$\"[10-30]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-36]?$	signal-peptide
tmhmm	$\"[15-44]?$ $\"[50-70]?$	transmembrane_regions

InterPro
IPR013216
Domain

Methyltransferase type 11
PF08241	$\"[39-137]T$	Methyltransf_11

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[17-190]T$	G3DSA:3.40.50.150
PTHR10108	$\"[4-104]T$	PTHR10108
PTHR10108:SF25	$\"[4-104]T$	PTHR10108:SF25
SSF53335	$\"[1-244]T$	SSF53335

","BeTs to 9 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","***** IPB000339 (ubiE/COQ5 methyltransferase family) with a combined E-value of 5.8e-10. IPB000339B 37-51 IPB000339C 58-75","Residues 38-102 are 50% similar to a (METHYLTRANSFERASE COMPLETE PROTEOME ARGININE) protein domain (PD006760) which is seen in Q9CIX7_LACLA.Residues 107-244 are 60% similar to a (PROTEOME COMPLETE AROD-COMER YCCK) protein domain (PD074506) which is seen in Q9CIX7_LACLA.Residues 31-146 are 31% similar to a (PROTEOME COMPLETE PA4178) protein domain (PD264117) which is seen in Q9HWK3_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 07:57:10 2002","Mon Sep 18 16:02:12 2006","Mon Sep 18 16:02:12 2006","Tue Oct 8 16:39:55 2002","Tue Mar 5 07:56:17 2002","Tue Mar 5 07:56:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1634 is paralogously related (blast p-value < 1e-3) to SMu1466, a conserved hypothetical protein.","Tue Mar 5 07:57:10 2002","","No significant hits to the NCBI PDB database.","SMU.1795c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 07:56:17 2002","24380160","","","","","","1","","","SMU.1795c","454" "SMu1635","1700162","1699809","354","ATGAAGGAAAAAAAATTACTGGAATTAATCGTTAAGGCCGCTGATGAAAAGCGGGCTGAAGATATTGTTGTGATGGATTTGCAGGGGCTGACAACCTTGACAGATTACTTTGTTATTATGCATGCGACTAATAGTCGTCAACTGGAAGCTATTGCTGAAAATATTCGTGAGAAGGTGCTTAAAGCTGGAGGCAATGCTAGCCATATTGAAGGTGATTCTAAAGGTGGTTGGGTGCTGCTTGACCTCAATGATGTTGTTGTCCATATCTTCTCAGAGGATGAGCGCTACCATTACAATCTCGAAAAACTTTGGCATGAAGCACCAATAGTGGACATGTCGAAATACTTAGCATAA","5.10","-5.80","13321","MKEKKLLELIVKAADEKRAEDIVVMDLQGLTTLTDYFVIMHATNSRQLEAIAENIREKVLKAGGNASHIEGDSKGGWVLLDLNDVVVHIFSEDERYHYNLEKLWHEAPIVDMSKYLA","1699825","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-117 are 71% similar to gi|15674477 from S.pyogenes and 70% similar to gi|15903631 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1659 (1e-47).","

InterPro
IPR004394
Family

Iojap-related protein
PTHR21043	$\"[1-112]T$	Iojap
PF02410	$\"[4-105]T$	DUF143
TIGR00090	$\"[1-108]T$	Iojap

","BeTs to 11 clades of COG0799COG name: Uncharacterized ACR (homolog of plant Iojap proteins)Functional Class: SThe phylogenetic pattern of COG0799 is -----qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003456 (Domain of unknown function DUF143) with a combined E-value of 1.1e-28. IPB003456A 21-48 IPB003456B 77-104","Residues 6-104 are 62% similar to a (COMPLETE PROTEOME IOJAP ORTHOLOG) protein domain (PD008103) which is seen in Q9CIX8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:39:14 2002","Tue Mar 5 07:59:56 2002","Tue Oct 8 16:39:14 2002","Tue Oct 8 16:39:14 2002","Tue Mar 5 07:59:56 2002","Tue Mar 5 07:59:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1635 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:39:14 2002","","No significant hits to the NCBI PDB database.","SMU.1797c","","Residues 4 to 105 (E-value = 1.1e-43) place SMu1635 in the DUF143 family which is described as Domain of unknown function DUF143 (PF02410)","Tue Mar 5 07:59:56 2002","24380161","","","","","","1","","","SMU.1797c","848" "SMu1636","1700756","1700163","594","ATGACCTATGAAGCTTATATTGCCATGAATCGAGACGATTTACTGAAAAAACTTAAATCGGTAGTTCCTAAAAAGCGTTTAAGACACATGATAGGTGTCGAAAAAGCTAGTATTTATTTAGCTGAAATCAATGGTTATGACACTGAGAAAGCTGGTTTAGCAGGGCTTTTGCATGATTATGCCAAGAAATTATCTGATCAGGAATTTTTACAACTCATTGATAAGTATCATCTTGATTCGCAATTAAAAAATTGGGGCAATAATGTCTGGCATGGAATGGTTGGCATTTATAAAATTCAAGAAGATTTGGGCTTGCAAGATCAAGAAATTCTGCGTGCCATTGAAATTCATACGGTAGGTTCTAGTCACATGTCAACTTTGGATAAGATTGTATATGTCGCTGATTATATCGAATGCAACCGTGATTTTTCGGGGGTGGACAAGGCGCGTGCCATTGCAGAAACGTCGTTGAATAAGGCTGTTGCTTATGAGACAGCTAGGACAGTTGCATTTTTGGCTAGTAAAGGTTTGAAAATTTATCCACAAACTCTAGAAACTTATAATGCTTATGTGGACTATTTAAGAGAGGATTAA","6.50","-1.60","22471","MTYEAYIAMNRDDLLKKLKSVVPKKRLRHMIGVEKASIYLAEINGYDTEKAGLAGLLHDYAKKLSDQEFLQLIDKYHLDSQLKNWGNNVWHGMVGIYKIQEDLGLQDQEILRAIEIHTVGSSHMSTLDKIVYVADYIECNRDFSGVDKARAIAETSLNKAVAYETARTVAFLASKGLKIYPQTLETYNAYVDYLRED","1700179","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-197 are 66% similar to gi|15901578 from S.pneumoniae. Residues 1-196 are 59% similar to gi|15674476 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1661 (2e-70).","

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[22-149]T$	HDc

InterPro
IPR005249
Family

Conserved hypothetical protein 488
TIGR00488	$\"[18-189]T$	CHP488

InterPro
IPR006674
Domain

Metal-dependent phosphohydrolase, HD region, subdomain
PF01966	$\"[26-140]T$	HD

","BeTs to 5 clades of COG1713COG name: Uncharacterized BCRFunctional Class: SThe phylogenetic pattern of COG1713 is ------vc-b----gp-l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 29-188 are 63% similar to a (PROTEOME COMPLETE ADENYLYLTRANSFERASE) protein domain (PD016808) which is seen in Q9CIY0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:38:28 2002","Tue Mar 5 08:02:46 2002","Tue Oct 8 16:38:28 2002","Tue Oct 8 16:38:28 2002","","Tue Mar 5 08:02:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1636 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:38:28 2002","","No significant hits to the NCBI PDB database.","SMU.1798c","","Residues 26 to 140 (E-value = 2e-10) place SMu1636 in the HD family which is described as HD domain (PF01966)","Tue Mar 5 08:02:46 2002","24380162","","","","","","1","","","SMU.1798c","716" "SMu1637","1701385","1700753","633","ATGGCTTTAGAACTGTTAACACCTTTTACTAAGGTGGAGTTGGAAGAAGAAAGAAAAGATAAAAATCGAAAACAAATTGGTATCTTAGGCGGCAATTTTAATCCGGTTCACAATGCTCATCTGTTAGTAGCGGATCAAGTACGCCAGCAATTGGGCTTGGATGAGGTCTTGCTGATGCCAGAATACAAACCACCACACGTTGATAAGAAGGCAACTATCGATGAAAAACATCGGCTCAAGATGCTGGAGTTAGCTATTAAAGGTATTGAAGGCTTGGCTATTGAAACTATTGAGCTCAAACGTAAAGGAGTCTCTTATACCTACGACACCATGAAAGATTTGATTGAACAAAATCCTGATGTTGATTATTATTTTATTATTGGTGCCGATATGGTAGACTATTTGCCTAAGTGGCACAAGATTGACGAGCTGATTCAGATGGTACAATTTGTTGGCGTACAGCGTCCTAAATATAAGGCTGGAACTTCTTATCCTGTCATTTGGGTAGATGTACCGCTTATGGATATTTCCTCTAGTATGATTCGAGATTTCATCCGTAAGAATAGAAAACCGAATTTTCTTTTACCAAAACTAGTTCTTGACTATATTGAGAAAGAAGGACTTTATCAATGA","6.70","-0.79","24426","MALELLTPFTKVELEEERKDKNRKQIGILGGNFNPVHNAHLLVADQVRQQLGLDEVLLMPEYKPPHVDKKATIDEKHRLKMLELAIKGIEGLAIETIELKRKGVSYTYDTMKDLIEQNPDVDYYFIIGADMVDYLPKWHKIDELIQMVQFVGVQRPKYKAGTSYPVIWVDVPLMDISSSMIRDFIRKNRKPNFLLPKLVLDYIEKEGLYQ","1700769","For other 'nad' genes see SMu0422 (nadE).","nicotinate mononucleotide adenylyltransferase (nicotinate-nucleotide adenylyltransferase)","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins and adenylyltransferases. Residues 1-209 are 83% similar to gi15901579 from S.pneumoniae. Residues 22-210 are 59% similar to gi15673081, a predicted NadD protein, from L.lactis. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1662 (1e-104).","

InterPro
IPR004820
Domain

Cytidylyltransferase
PF01467	$\"[28-184]T$	CTP_transf_2

InterPro
IPR004821
Domain

Cytidyltransferase-related
TIGR00125	$\"[26-91]T$	cyt_tran_rel

InterPro
IPR005248
Family

Probable nicotinate-nucleotide adenylyltransferase
PTHR12039	$\"[13-210]T$	NAMN_adtrnsfrase
TIGR00482	$\"[28-209]T$	NAMN_adtrnsfrase

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[22-210]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
SSF52374	$\"[22-210]T$	SSF52374

","BeTs to 11 clades of COG1057COG name: Predicted nucleotidyltransferasesFunctional Class: RThe phylogenetic pattern of COG1057 is ----Yqvcebr-ujgpol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 28-155 are 65% similar to a (ADENYLYLTRANSFERASE DEAMIDO-NAD NICOTINATE-NUCLEOTIDE) protein domain (PD009578) which is seen in NADD_LACLA.Residues 164-209 are 60% similar to a (ADENYLYLTRANSFERASE DEAMIDO-NAD) protein domain (PD405848) which is seen in Q9CIY1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 16:45:29 2006","Wed Oct 23 10:29:26 2002","Thu Aug 31 16:45:29 2006","Thu Apr 11 11:14:03 2002","","Tue Mar 5 08:04:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1637 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 08:07:45 2002","","No significant hits to the NCBI PDB database.","SMU.1799c","","Residues 28 to 184 (E-value = 3.6e-62) place SMu1637 in the CTP_transf_2 family which is described as Cytidylyltransferase (PF01467)","Tue Mar 5 08:04:39 2002","","","","Olland AM, Underwood KW, Czerwinski RM, Lo MC, Aulabaugh A, Bard J, Stahl ML, Somers WS, Sullivan FX, Chopra R.Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.J Biol Chem. 2002 Feb 1;277(5):3698-707.PMID: 11704676 ","","Tue Mar 5 08:09:32 2002","1","","","SMU.1799c","601" "SMu1638","1701720","1701412","309","ATGCTTACAAGTAAACAGCGTGCCTTTTTAAAATCGGAGGCACATTCTCTGAAACCCATTGTGCAGATTGGGAAAAATGGTCTCAACGACCAAATCAAAACCAGCGTTAGAAACGCTCTTGATGCACGTGAATTGATTAAAGTAACTCTTTTGCAGAACACTGATGAGGATATTCACGAAGTGGCTGAAATTTTGGAAGATGAGATTGGTTTGGAGACCGTCCTTAAAATTGGACGCATTTTGATTCTTTATAAGGAGTCCAGTCGTAAGGACAATCGGAAACTTTCGGTCAAGGTTAAAGCGATCTAA","10.10","3.47","11517","MLTSKQRAFLKSEAHSLKPIVQIGKNGLNDQIKTSVRNALDARELIKVTLLQNTDEDIHEVAEILEDEIGLETVLKIGRILILYKESSRKDNRKLSVKVKAI","1701428","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-102 are 89% similar to gi|15674474 from S.pyogenes. Residues 2-102 are 83% similar to gi|15901580 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1663 (7e-49).","

InterPro
IPR001890
Domain

CRS1/YhbY
PD010559	$\"[9-96]T$	UPF0044
PF01985	$\"[2-85]T$	CRS1_YhbY
TIGR00253	$\"[2-99]T$	CRS1_YhbY

noIPR
unintegrated

unintegrated
G3DSA:3.30.110.60	$\"[2-97]T$	G3DSA:3.30.110.60
SSF75471	$\"[1-97]T$	SSF75471

","BeTs to 5 clades of COG1534COG name: Predicted RNA-binding protein containing KH domainFunctional Class: RThe phylogenetic pattern of COG1534 is amtk----eb-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB001890 (Uncharacterized protein family UPF0044) with a combined E-value of 1.3e-17. IPB001890 2-41","Residues 23-85 are 47% similar to a (PROTEOME COMPLETE AROD-COMER VNG0601H) protein domain (PD010559) which is seen in Q9KD92_BACHD.Residues 2-102 are 58% similar to a (PROTEOME YCCF COMPLETE) protein domain (PD394140) which is seen in Q9CIY2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:35:50 2002","Tue Mar 5 08:12:27 2002","Tue Oct 8 16:35:50 2002","Tue Oct 8 16:35:50 2002","Tue Mar 5 08:12:27 2002","Tue Mar 5 08:12:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1638 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:35:50 2002","","No significant hits to the NCBI PDB database.","SMU.1800c","","Residues 2 to 85 (E-value = 3.3e-33) place SMu1638 in the CRS1_YhbY family which is described as CRS1 / YhbY domain (PF01985)","Tue Mar 5 08:12:27 2002","24380164","","","","","","1","","","SMU.1800c","849" "SMu1639","1702883","1701777","1107","GTGGAAGAATTATTTTGTATCGGCTGTGGAGCGCAAATTCAAACGACAGCCAAAGAGCAAGCTGGCTATACACCAAAGTCAGCCTTGGAAAAAGGGCTTGAAAGCGGGAAAATATACTGCCAACGCTGTTTTAGACTGCGTCATTATAACGAAATCACAGATGTGCATATTTCAGATGATGATTTTTTAAAGCTTCTCCATGAAGTGGGGGACAGCAGGACTCTTGTTGTTAATGTGATTGATATTTTTGATTTTAATGGCTCCGTTATACCGGGATTGCAGCGTTTTATCTCTAGCAGTGATTTGCTTTTAGTGGGAAATAAAGCGGACATTCTCCCCAAATCAGTCAAATCTGGGAAAATAACACAGTGGCTGATGGAGCGTGCGCATGAAGAAGGGTTGCGGCCGCTTGATCTTATCTTAATCAGTGCCCAGAATAAATGGGCGATAAAAGAATTAATTGCTAAGATTGAAGAACTTCGTCAGGGACGGGATGTCTATGTTGTTGGTGTTACTAATGTTGGGAAATCAACTCTTATCAATGCCATTATTCAGGAAATCACTGGTGATAAAAATATTATCACAACATCGCGTTTTCCGGGAACGACCCTGAATAAGATTGAAATTCCTCTGAATGATGGTTCCTATATTTTTGATACGCCGGGGATTATCCACCGTCATCAGATGGCTCATTACTTATCAGACAAGGCTCTCAAGTATATCAGTCCTAAAAAAGAAATCAAGCCTAAAACTTACCAACTCAATCCTGAACAGACGCTCTTTTTAGGCGGTTTGGCTCGTTTTGATTATGTAACGGGCGATAAGCAAGGCTTTACAGCTTATTTTGATAATAATCTCAAATTACACAGAACTAAGTTGGCTGGAGCGGATGCTTTCTATGACAAACATATCGGCAGCCTTTTGACGCCGCCAGATAAGAAGGAAATGGCAGCCTTTCCCAAATTGGTAAGGCATGAATTTACGATAAAAGAAAAGACAGATCTTGTTTTTTCAGGTTTGGGTTGGATTCGCATCAATGGCAGAGCCAAAATTGCTGCTTGGGCACCTGAAGGGGTTGCTGTTGTGACAAGAAAAGCCTTAATTTGA","9.40","8.23","41211","MEELFCIGCGAQIQTTAKEQAGYTPKSALEKGLESGKIYCQRCFRLRHYNEITDVHISDDDFLKLLHEVGDSRTLVVNVIDIFDFNGSVIPGLQRFISSSDLLLVGNKADILPKSVKSGKITQWLMERAHEEGLRPLDLILISAQNKWAIKELIAKIEELRQGRDVYVVGVTNVGKSTLINAIIQEITGDKNIITTSRFPGTTLNKIEIPLNDGSYIFDTPGIIHRHQMAHYLSDKALKYISPKKEIKPKTYQLNPEQTLFLGGLARFDYVTGDKQGFTAYFDNNLKLHRTKLAGADAFYDKHIGSLLTPPDKKEMAAFPKLVRHEFTIKEKTDLVFSGLGWIRINGRAKIAAWAPEGVAVVTRKALI","1701793","","conserved hypothetical protein, GTP-binding","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-368 are 80% similar to gi15674473 from S.pyogenes and 80% similar to gi15903636 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1664 (1e-174).","

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[164-269]T$	MMR_HSR1

InterPro
IPR005289
Domain

GTP-binding
TIGR00650	$\"[169-222]T$	MG442: GTP-binding conserved hypothetical p

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[50-227]T$	no description
PTHR11089	$\"[79-368]T$	GTP-BINDING PROTEIN-RELATED
PTHR11089:SF3	$\"[79-368]T$	GTP-BINDING PROTEIN-RELATED PLANT/BACTERIA

","BeTs to 6 clades of COG1161COG name: Predicted GTPasesFunctional Class: RThe phylogenetic pattern of COG1161 is -m-kY-Vc-B----gpo----Number of proteins in this genome belonging to this COG is 2","***** IPB000765 (GTP1/OBG family) with a combined E-value of 5e-06. IPB000765 164-207","Residues 38-267 are 27% similar to a (I C2F7.09C CHROMOSOME) protein domain (PD143245) which is seen in YA29_SCHPO.Residues 34-157 are 28% similar to a (F3H7.11) protein domain (PD215797) which is seen in Q9T0C0_ARATH.Residues 168-225 are 74% similar to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9CIY5_LACLA.Residues 75-157 are 36% similar to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in O18196_CAEEL.Residues 6-64 are 59% similar to a (PROTEOME COMPLETE GTP-BINDING) protein domain (PD041802) which is seen in Q9KD94_BACHD.Residues 228-368 are 63% similar to a (COMPLETE PROTEOME 2610024G14RIK Y48E1B.2B) protein domain (PD294057) which is seen in Q9CIY5_LACLA.Residues 65-167 are 54% similar to a (PROTEOME COMPLETE GTP-BINDING NUCB-AROD) protein domain (PD404577) which is seen in Q9CIY5_LACLA.Residues 59-160 are 28% similar to a (PROTEOME COMPLETE) protein domain (PD394920) which is seen in Q9WZV2_THEMA.Residues 6-114 are 33% similar to a (2610024G14RIK X96994 BR-1 Y48E1B.2) protein domain (PD273589) which is seen in Q9V8C9_DROME.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 08:35:19 2002","Mon Sep 18 16:08:58 2006","Mon Sep 18 16:08:58 2006","Tue Oct 8 16:32:12 2002","Tue Mar 5 08:34:35 2002","Tue Mar 5 08:34:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1639 is paralogously related (blast p-value < 1e-3) to SMu0903, a predicted GTP-binding protein.","Tue Mar 5 08:35:19 2002","","No significant hits to the NCBI PDB database.","SMU.1801c","","Residues 62 to 346 (E-value = 8.3e-31) place SMu1639 in the MMR_HSR1 family which is described as GTPase of unknown function (PF01926)","Tue Mar 5 08:34:35 2002","24380165","","","","","","1","","","SMU.1801c","455" "SMu1640","1703411","1702884","528","GTGAGTATCGAAAATTATCGACCCGATTTCGTGGTAGAAGCCGTTTATGATTTAACCCCTGATAGCCTGCGAAAGCACGGTATTAAAGCCGTTCTTGTCGATTTGGACAATACCTTAATTGCTTGGGATCATCCTGATGGTACACCCCAGTTGCGGGATTGGCTGGACAGTATGACTGAAGCAGATATGCCGGTAGTCGTGGTATCTAACAATAGTTATACACGTGTCAAACGGGCTGTCAAAGGTTTTCATGTAGATTTTGTCAGTCGGGCTCTGAAACCTTTTTCTCGCGGTATTAATATGGCAGTGAATCGCTATGGCTTTTCTAAAGATGAAGTTGTTATGGTGGGCGATCAGCTAATGACGGATATTCGTGCGGCTCACCGTGCTGGTGTTAAAAGTATTTTGGTTAAACCTTTGGTTAAGTCAGATGCTTGGAATACTAAGTTTAACCGTGCGCGTGAGCGTCGTGTTTGGAAAAAAATAGAAGACAAATATGGTGCTTTTGTCTATAAAAAGGAAATTTAA","10.30","6.96","20054","MSIENYRPDFVVEAVYDLTPDSLRKHGIKAVLVDLDNTLIAWDHPDGTPQLRDWLDSMTEADMPVVVVSNNSYTRVKRAVKGFHVDFVSRALKPFSRGINMAVNRYGFSKDEVVMVGDQLMTDIRAAHRAGVKSILVKPLVKSDAWNTKFNRARERRVWKKIEDKYGAFVYKKEI","1702900","","conserved hypothetical protein","Cytoplasm","Similarities in gapped BLAST to conserved hypothetical proteins. Residues 1-175 are 68% similar to gi|15674472 from S.pyogenes and 62% similar to >gi|15903637 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1665 (2e-75).","

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[64-140]T$	Hydrolase

InterPro
IPR006549
Domain

HAD-superfamily hydrolase, subfamily IIIA
TIGR01662	$\"[29-140]T$	HAD-SF-IIIA: hydrolase, HAD-superfamily, su

InterPro
IPR010021
Family

HAD-superfamily phosphatase, subfamily IIIA
TIGR01668	$\"[4-171]T$	YqeG_hyp_ppase: HAD superfamily (subfamily

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[27-137]T$	no description
PTHR19288	$\"[93-138]T$	4-NITROPHENYLPHOSPHATASE-RELATED

","BeTs to 3 clades of COG2179COG name: Uncharacterized proteins, HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG2179 is ------vc-b-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 85-156 are 62% similar to a (PROTEOME COMPLETE YXAC) protein domain (PD413290) which is seen in Q9CDJ8_LACLA.Residues 7-83 are 59% similar to a (PROTEOME COMPLETE NUCB-AROD BH1322) protein domain (PD077900) which is seen in Q9CDJ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 08:39:22 2002","Tue Mar 5 08:38:02 2002","Tue Mar 5 08:39:22 2002","Tue Oct 8 16:31:13 2002","","Tue Mar 5 08:38:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1640 is paralogously related (blast p-value < 1e-3) to SMu1290, a predicted phosphatase, and to SMu0702, a conserved hypothetical.","Tue Mar 5 08:39:22 2002","","No significant hits to the NCBI PDB database.","SMU.1802c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 08:38:02 2002","24380166","","","","","","1","","","SMU.1802c","717" "SMu1641","1704133","1703516","618","ATGAAGATGTTAAAGAAAATTTTGGGTTGTAAAATCTATATTTGGTTTGCTGCACTGATAGCTTTGGTGGGATTGTTTTTTTATTGGTATGGTATGAATCAAAACAATAATAAATCTGCTGATAGTTCTCAATCTTATTCAATAGTGAAATATATTGAAGCGACAAATGAAACGGTTTTCTTGAATGTAGGGATTGAAAAAGTAGATGCACTTTCTAATGCGACTAAAGTACTTGGGATAACGATTCCTTACTCGCAAAAGAAAGCAATTATCATTTTGAATTATGAAGCAAAACTAGGGATTAAAAGGGCTGTTTCAATAAATAAAACGAGAGAGAATAATTTTGAAATTAAAATTCCTAAATTTGAAGTTATTGGTGTAAAATTGGATGATAAGCATCCATATAAACTGTACAATAGAAGTGGCGAATTATTAAGCGGCTCTACAGAAGAAGTAGATACGGGTAAAGCTGCCACATCGTTGCTAACTAATAAAGAACAGAAAAAATATTTGAAACAGTATTCTGATATGATTAAAAAGTCTGCTGAAGATCATTATAAAGTTTTATTTAAATCTATTTATCCTGATGTTAAGTTGACCTTTGTTTACGAAAATTAA","10.20","10.43","23423","MKMLKKILGCKIYIWFAALIALVGLFFYWYGMNQNNNKSADSSQSYSIVKYIEATNETVFLNVGIEKVDALSNATKVLGITIPYSQKKAIIILNYEAKLGIKRAVSINKTRENNFEIKIPKFEVIGVKLDDKHPYKLYNRSGELLSGSTEEVDTGKAATSLLTNKEQKKYLKQYSDMIKKSAEDHYKVLFKSIYPDVKLTFVYEN","1703532","","conserved hypothetical protein","Membrane, Extracellular","A single weak match in gapped BLAST: residues 11-204 are 22% similar to gi|19551586, an hypothetical protein from Corynebacterium glutamicum ATCC 13032.SMu1641 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-31]?$	signal-peptide
tmhmm	$\"[12-32]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-38]?$	signal-peptide
tmhmm	$\"[21-43]?$	transmembrane_regions

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[1-40]T$	TetR_N
PS50977	$\"[1-50]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[1-61]T$	Homeodomain_like

InterPro
IPR010916
Domain

TonB box, N-terminal
PS00430	$\"[1-111]?$	TONB_DEPENDENT_REC_1

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[1-39]T$	Homeodomain-rel

","BeTs to 8 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 1.1e-12. IPB001647 8-38","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 08:56:56 2002","Tue Mar 5 08:56:09 2002","Wed Oct 16 10:31:35 2002","Wed Oct 16 10:31:35 2002","Tue Mar 5 08:56:09 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1643 is paralogously related (blast p-value < 1e-3) to SMu0539, a predicted transcriptional regulator.","Tue Mar 5 08:56:56 2002","","No significant hits to the NCBI PDB database.","SMU.1805","","Residues 1 to 42 (E-value = 9.5e-08) place SMu1643 in the TetR_N family which is described as Bacterial regulatory proteins, tetR family (PF00440)","Tue Mar 5 08:56:09 2002","24380169","","","","","","1","","","SMU.1805","" "SMu1644","1705116","1706285","1170","ATGATGAAAAAAACACACTATAACATTTTAATGGTTAATCTTCCTTTTTCCGGCCATACCAATCCGACTTTGGGACTTGCTCAAATTTTAGTCCAGCTAGGTCATAATGTCACCTATATTAATGCTCCTGATTGGCAAAGTAAGATTGAAAGAACGGGTGCACATTTTGTTCCTTATGACCATTATCCAGATTCGTTATCAGAAAGGCAAAAGAAAGTTAAAAGCTGGTCAGCTGCCTATCAGACTGTCTTACGTATGGGTAAAGATTACGATTGTTTGATTTATGAAATGCTATTCTTTCCAGGAAAAGCTCTAGCGGACAGACTGAATATTCCAGCTTATCGGCTATTCTCAACTTTTTCCTTAAATGAAAAAATTCTGACAGAATTTGGGAAAACAGGTGGCTTTTATTTGACCAGTATTTTTCGCTTCACTTTTCTGCGCCATCTTTTATCAAGAAAATTGCAAAGAACCTTTCAGCTGGCTTATGATGATCTTGCTAAGGAAATCAGTCTTAATACTCCCGAACTCAATTTCACGTATACAGTACGGGAATTTCAAATTGATGCTGATACGTTTGATGAAAATCACTATCAATACGTTGGGCCTTCCATCAATCGTCCTGTCGAGCCGCCTTTTGATTTCACACCTTTTAAAAATCCGATTATTTATATTTCATTAGGTACTCTCCTCAATCGCTCTGTCTCCTTTTTTAAAAAATGTATCAAGGCTTTTGAAAACGAGCCCTACTCTATCATCATTTCACTTGGAAATAGGATTAAAAAAGAACAACTAGGAACAATGCCAGCCAATGTTCATCTTTATTCTTTCGTTCCTCAACTCCAAATCTTGGAAAGAGCTTCACTTTTTCTTACTCATGGTGGCATGAACAGTGTTAATGAAGCTATCTATTATGGCTGCCCTATGCTAGTGATTCCTGTTGGCAACGATCAGCCTCGAGTCGCCCAGCAAGTTGCTGATTTACATTTGGGAAAATGCCTCAAGTGTCACAACTTAAATCCTCAAGAAATCAAACAAGCAGCCCATACAATTCTTAAAGATTCTTCTTACAAAAATACTATCTGGCATTTTCAAAAGATTGCTCAAACTGCTGGCGGAAATACCCTAATAGCTCAAACTATTATCAAAGATTTACAAACCAAACCTTAA","9.70","11.89","44548","MMKKTHYNILMVNLPFSGHTNPTLGLAQILVQLGHNVTYINAPDWQSKIERTGAHFVPYDHYPDSLSERQKKVKSWSAAYQTVLRMGKDYDCLIYEMLFFPGKALADRLNIPAYRLFSTFSLNEKILTEFGKTGGFYLTSIFRFTFLRHLLSRKLQRTFQLAYDDLAKEISLNTPELNFTYTVREFQIDADTFDENHYQYVGPSINRPVEPPFDFTPFKNPIIYISLGTLLNRSVSFFKKCIKAFENEPYSIIISLGNRIKKEQLGTMPANVHLYSFVPQLQILERASLFLTHGGMNSVNEAIYYGCPMLVIPVGNDQPRVAQQVADLHLGKCLKCHNLNPQEIKQAAHTILKDSSYKNTIWHFQKIAQTAGGNTLIAQTIIKDLQTKP","1706295","","macrolide-related glycosyltransferase","Cytoplasm","Similarities in gapped BLAST to macrolide-related glycosyltransferases. Residues 2-373 are 31% similar to gi|16078287 from B.subtilis. Residues 9-373 are 32% similar to gi|7480724| from S.coelicolor.SMu1644 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002213
Family

UDP-glucuronosyl/UDP-glucosyltransferase
PTHR11926	$\"[7-334]T$	UDP_glucos_trans
PF00201	$\"[290-361]T$	UDPGT
PS00375	$\"[277-318]?$	UDPGT

InterPro
IPR006326
Family

UDP-glycosyltransferase, MGT
TIGR01426	$\"[12-387]T$	MGT

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2000	$\"[2-117]T$ $\"[207-367]T$	G3DSA:3.40.50.2000
PTHR11926:SF2	$\"[7-334]T$	PTHR11926:SF2
SSF53756	$\"[7-381]T$	SSF53756

","BeTs to 5 clades of COG1819COG name: Glycosyl transferases, related to UDP-glucuronosyltransferaseFunctional Class: G,CThe phylogenetic pattern of COG1819 is -mt-y--C-BR----------Number of proteins in this genome belonging to this COG is 1","***** IPB002213 (UDP-glucoronosyl and UDP-glucosyl transferase) with a combined E-value of 5e-16. IPB002213 275-321","Residues 109-265 are 30% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE PROTEOME) protein domain (PD011043) which is seen in O34539_BACSU.Residues 268-358 are 46% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD000190) which is seen in Q9S1V2_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 10:25:20 2002","Tue Mar 5 09:00:57 2002","Wed Oct 16 10:25:20 2002","Wed Oct 16 10:25:20 2002","Tue Mar 5 09:00:57 2002","Tue Mar 5 09:00:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1644 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 10:25:20 2002","","No significant hits to the NCBI PDB database.","SMU.1806","","Residues 222 to 385 (E-value = 5.3e-05) place SMu1644 in the Glyco_tran_28_C family which is described as Glycosyltransferase family 28 C-terminal domain (PF04101)","Tue Mar 5 09:00:57 2002","24380170","","","","","","1","","","SMU.1806","" "SMu1645","1707224","1706316","909","ATGAAGAAATCGTTTAAGGGAACGGTTCTTGTTGTTCTAGCAGCCATTGCTTGGGGCATATCAGGAGTGTCGGGCCAATTTTTAATGAAGCAGGGCATTTCTGTCTATTTATTGACTTCTTTGCGTTTATTGATATCAGGGCTACTTTTAATTGGAGTTGTCATTTGGCAACAGCCTCAGCAGATCAAAGCTATTCTAGAGGATAAAAAGATGTTAGTAGGGATTTTTGGTTTTAGCATTTGTGGACTGCTTCTGAATCAATTTAGTTATTTGCAGGCTATTCATTATACTAATGCTGGAACGGCAACTGTCCTACAATATATGGCACCTGTTTTAGTTTTGACAATTATTTGTTTTAAGAATCGCAGTTTGCCAACTATAGGTGAACTTGCTGCCATTCTTTTAGCTATTTTGGGGACATTTGTCATAGCAACGCATGGACAGTTGGGCAATCTCGCTCTGTCTCCAGTTGGTCTTTTTTGGGGTCTCTTTTCTGCTGTGACTTATACTCTTTATATGCTTTTGCCCATTAAACTCATTCATAAATGGGGGAGCCTCTTAGTTATTGGATTAGGTATGGTAATGGGAGGACTGGTATTTGGTCTAGTCAGCCGGTCTTGGCAATACAATTCTCATTTTCAGGCAAATAACCTGTTGGCTTATGTTGGTTTAATCATTGTTGGCAGTGTTTTTGCTTATACTGCTTTTTTAAAGGGAGTCAGTCTTATTGGTGCTGTAAAAGGCAGCCTTCTGGCTTCTATTGAACCAGTAGCAGCAGTCTTTTTTTCAGTTACTCTTATGAAAGAAATTTTTTACCCCATCGATTTCCTAGGCATGCTGTTGATTATACTAGCCGTTCTTATCATTTCTATCAGAGACTTATTAGTAACCAATAAAGAAAAAATCTGA","10.50","11.85","32714","MKKSFKGTVLVVLAAIAWGISGVSGQFLMKQGISVYLLTSLRLLISGLLLIGVVIWQQPQQIKAILEDKKMLVGIFGFSICGLLLNQFSYLQAIHYTNAGTATVLQYMAPVLVLTIICFKNRSLPTIGELAAILLAILGTFVIATHGQLGNLALSPVGLFWGLFSAVTYTLYMLLPIKLIHKWGSLLVIGLGMVMGGLVFGLVSRSWQYNSHFQANNLLAYVGLIIVGSVFAYTAFLKGVSLIGAVKGSLLASIEPVAAVFFSVTLMKEIFYPIDFLGMLLIILAVLIISIRDLLVTNKEKI","1706332","","permease","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical membranes and possible integral membrane proteins. Residues 1-296 are 45% similar to gi15903345 from S.pneumoniae. Residues 1-267 are 28% similar to gi15804252, a predicted permease transporter, from E.coli.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1666 (6e-75).","

InterPro
IPR000620
Domain

Protein of unknown function DUF6, transmembrane
PF00892	$\"[16-145]T$ $\"[167-291]T$	DUF6

noIPR
unintegrated

unintegrated
SSF103481	$\"[41-148]T$ $\"[191-298]T$	SSF103481

","BeTs to 3 clades of COG0697COG name: Predicted permeasesFunctional Class: RThe phylogenetic pattern of COG0697 is A-tKYQVCEB-Huj---lINxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 6-110 are 30% similar to a (PROTEOME COMPLETE MEMBRANE TRANSPORT) protein domain (PD058303) which is seen in YICL_ECOLI.Residues 139-267 are 29% similar to a (PROTEOME COMPLETE TRANSPORT TRANSMEMBRANE) protein domain (PD111415) which is seen in YICL_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 09:04:58 2002","Tue Mar 6 10:22:33 2007","Mon Sep 18 16:15:47 2006","Tue Oct 8 16:29:18 2002","","Tue Mar 5 09:01:37 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1645 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 09:04:58 2002","","No significant hits to the NCBI PDB database.","SMU.1807c","","Residues 16 to 145 (E-value = 2.4e-12) place SMu1645 in the DUF6 family which is described as Integral membrane protein DUF6 (PF00892)Residues 167 to 291 (E-value = 6.9e-17) place SMu1645 in the DUF6 family which is described as Integral membrane protein DUF6 (PF00892)","Mon Sep 18 16:15:47 2006","24380171","","","","","","1","","","SMU.1807c","456" "SMu1646","1707414","1707319","96","ATGACAACTACGCAAAAAACGTATTTACATATTATTCGTGAACTGGAAAATCAAGATATTGATTTGATTATGCGTTCATTAACAAGTCTGACTTAA","5.60","-0.78","3661","MTTTQKTYLHIIRELENQDIDLIMRSLTSLT","1707335","","integrase fragment","Extracellular, Cytoplasm","One weak match in gaped BLAST to a bacteriophage integrase fragment, gi|16799599, from L.inocua. Residues 1-30 are 73% similar to this fragment.SMu1646 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 10:22:03 2002","Tue Mar 5 11:11:21 2002","Wed Oct 16 10:22:03 2002","Tue Mar 5 11:11:21 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1646 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 10:22:03 2002","","No significant hits to the NCBI PDB database.","SMU.1808c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 11:11:21 2002","24380172","","","Reichmann P, Hakenbeck R. A XerD recombinase with unusual active site motifs in Streptococcus pneumoniae.J Mol Microbiol Biotechnol. 2002 Jan;4(1):101-10.PMID: 11763967 ","","Sat Oct 26 16:49:22 2002","1","","","SMU.1808c","" "SMu1647","1708519","1707788","732","ATGAAGTATTTATCTTCTGAATGGCTTAAATTACGTAAAATCCAGCTTTTACTAGTAGGTCTTATCTTGCTTTCAATAGGAAGTTTTGTTGGACTAGGAACCTATTATGCCAATAGACAAGTCTTTATTCATGACACTCAGTCTCGGGTCATGTGGGGACAATTAACGTTTTATCATAGCCAGGTCTTCTACCCTGCTTTACTTGCCATCTTTGTGGGGATTAGTTTAATGCCAGAGTTTGAGAGAATGACCTTTGAAATGTTGAAGGCTAATAATGTATCAATAGGCAAGCTATTGATGAGCAAATTACTTACTTTAACGTTCACTTTAGTTCCCTTTCAGTTTTTGCTGGTTGTGATTTGGTGGGTTGGCTTGAAACTTGATAATATTAGTGTTACTTCAGAAATAGGGGTTCATATAAAATGGGTATTATTATCGTTGATTGGGTCGCTTAGTATTTTAAGTCTGCAGTCTTTCATTCTAGTTAAAACCAAAAGTTTTGCCAAATCAGTTGGCTTTTCTGCTATGGGGGTAATGGTTGGTTTTGTACTCATGCTGGTTTTTGAACCGCTCAGTCATATCTGTCCTTATTCACAACCAATGATAGGGTTACGTGCTAGAGCCTTAGCAGATATGTCATTTTCGGAGTTTGTTATCTTTATAGTGGTAAATGTCTTCTATACATTGCTTTTTTACAAACTGACACAGCGGACACTGGAGAAAAAAGGGTAG","10.60","10.90","27618","MKYLSSEWLKLRKIQLLLVGLILLSIGSFVGLGTYYANRQVFIHDTQSRVMWGQLTFYHSQVFYPALLAIFVGISLMPEFERMTFEMLKANNVSIGKLLMSKLLTLTFTLVPFQFLLVVIWWVGLKLDNISVTSEIGVHIKWVLLSLIGSLSILSLQSFILVKTKSFAKSVGFSAMGVMVGFVLMLVFEPLSHICPYSQPMIGLRARALADMSFSEFVIFIVVNVFYTLLFYKLTQRTLEKKG","1707804","For other components see SMu1649 (NBD1) and SMu1648 (MSD1).For other 'scn' genes see SMu1048 (scnR); SMu1648 (scnE);SMu1649 (scnF) ; SMu1652 (scnK) and SMu1653 (scnR)."," cdd2-related, bacteriocin related ABC element","Membrane, Cytoplasm","Limited matches to various proteins in gapped BLAST. Residues 26-243 are 46% similar to gi7474189 from S.pyogenes. Residues 30-242 are 25% similar to gi2581775 from L.lactis.SMu1647 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-27]?$	signal-peptide
tmhmm	$\"[15-37]?$ $\"[62-80]?$ $\"[103-123]?$ $\"[142-162]?$ $\"[172-192]?$ $\"[211-231]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 26-130 are 52% similar to a (LCTE MEMBRANE SCND MUTG) protein domain (PD357441) which is seen in O31056_STRPY.Residues 163-241 are 55% similar to a (LCTG MEMBRANE SCND MUTG) protein domain (PD115336) which is seen in O31056_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:58:06 2005","Tue May 3 12:57:19 2005","Tue May 3 12:57:19 2005","Tue Mar 5 11:12:18 2002","","Tue Mar 5 11:12:18 2002","yes","Mon Oct 21 11:03:20 2002","SMu1647 is paralogously related (blast p-value < 1e-3) to SMu1052, a possible ABC transporter, to SMu1648, a bacteriocin-related component, ScnE, and to SMu1051, an ABC-related protein.SMu1052 corresponds most closely to a previously sequenced MUTII MutG protein (Qi et al., 1999).","Tue May 3 12:58:06 2005","","No significant hits to the NCBI PDB database.","SMU.1809c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 11:12:18 2002","","","","Qi,F., Chen,P. and Caufield,P.W.Functional analyses of the promoters in the lantibiotic mutacin IIbiosynthetic locus in streptococcus mutansAppl. Environ. Microbiol. 65 (2), 652-658 (1999)PubMed: 9925596","Tue May 3 12:58:06 2005","Tue May 3 12:57:19 2005","1","","","SMU.1809c","" "SMu1648","1709271","1708519","753","ATGACAAAAGCAATTCAAGTTGAATGGCTGAAAAGCAAGCGAACAAAATCTCTGACCGTTTCTACTCTTATTATTCTTATTGGGGTATTTTGGTCAATTCTTGGAACAGTAATGCAAAAATCATCGTCTGGTTGGGAAATGTTTTTTGATAATCAAGATGCCCTTCCCATGTTTCTGCCACTAGCTATTAGTATTTTTGTTTCACGTATTATAAGTAATGAAAAAGAAGGCAGAACCTTTAAATTACAAGCAAGTAATGCCCATGGGATACTTGAAATATTCCACAATAAATTATGGTTTACAAGTTTATTCTTTTTCTCTATGGCAGTGGTATATACTTCGATAATTTCATTTTATGTTACCTTTATCAAAGGAGAATCAATTTCTGGCCTTGCGCCCGTCCATCAGATAGTGACGTTTACCTTAGGAAGCTTTGTACAAATTTGCCTTTATATAGTTATGGCAATGATAATAGAAAAACAAAGTGCCGTGTTGGCAACTGGATTTCTCGGGGCTTTTGTGGGTATAGTATTTCAACGTCTTTCAATGAAATTCTGGTCTTTTTTCATTCCTTGGTTAGGAACAAGTTTCTTAGCAATGTATCACTTTGGTTATGATGATAAAACAGAAACGGCGTTCGCTACTTTGGATAATCAAATATTCTTAAAGCTCATTGTATATAGCATGTATGCTGTACTGTGCTATCTAGCAGCGAGATATATTGTTTCGCATAAAGGAGGAGAACTGTTATAA","9.80","6.10","28339","MTKAIQVEWLKSKRTKSLTVSTLIILIGVFWSILGTVMQKSSSGWEMFFDNQDALPMFLPLAISIFVSRIISNEKEGRTFKLQASNAHGILEIFHNKLWFTSLFFFSMAVVYTSIISFYVTFIKGESISGLAPVHQIVTFTLGSFVQICLYIVMAMIIEKQSAVLATGFLGAFVGIVFQRLSMKFWSFFIPWLGTSFLAMYHFGYDDKTETAFATLDNQIFLKLIVYSMYAVLCYLAARYIVSHKGGELL","1708535","For other components see SMu1649 (NBD1) and SMu1647 (MSD2).For other 'scn' genes see SMu1048 (scnR); SMu1647 (scnG);SMu1649 (scnF) ; SMu1652 (scnK) and SMu1653 (scnR).","ABC transporter, membrane spanning permease","Membrane, Cytoplasm","Matches in gapped BLAST to cdd3-like ScnE homologs and other proteins. Residues 1-248 are 33% similar to gi7474191 from S.pyogenes. Residues 1-202 are 26% similar to gi2581774 from L.lactis.Siimilar to a MutII mutE sequence from another strain (GI:4322366).SMu1648 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[54-72]?$ $\"[103-123]?$ $\"[137-157]?$ $\"[185-205]?$ $\"[224-242]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-248 are 33% similar to a (SCNE) protein domain (PD401016) which is seen in O31055_STRPY.Residues 24-201 are 19% similar to a (SUBUNIT EPIE MEMBRANE PLASMID) protein domain (PD115338) which is seen in Q9Z6D9_STRMU.Residues 3-176 are 27% similar to a (PROTEOME COMPLETE GENES CDD1) protein domain (PD232936) which is seen in P94626_CLODI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:51:18 2005","Tue May 3 12:51:18 2005","Tue May 3 12:51:18 2005","Tue Mar 5 12:21:59 2002","","Tue Mar 5 12:21:59 2002","yes","Mon Oct 21 11:02:30 2002","SMu1648 is paralogously related (blast p-value < 1e-3) to SMu1051, a predicted ABC element, and to SMu1647, an ScnG bacteriocin protein, cdd2-related.","Tue Mar 5 12:25:49 2002","","No significant hits to the NCBI PDB database.","SMU.1810c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 12:21:59 2002","","","Bekal-Si Ali S, Hurtubise Y, Lavoie MC, LaPointe G. Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes.Gene. 2002 Jan 23;283(1-2):125-31.PMID: 11867219 ","","Sat Oct 26 16:36:23 2002","","1","","","SMU.1810c","" "SMu1649","1710181","1709273","909","ATGGACAATGTTATTGAACTACAGAATTTAACAAAGGTATACAATGGTGTGACGACAGTAGACCTTAAAAAGATTACTGTGCATCAGGGGGAAATATATGGTTTTCTTGGGCCAAATGGTGCTGGTAAGACAACAACGATGAAGATGATTTTGTCACTTATTGCACCAACTTCAGGAAACGTTTTAGTGAATGACAGTAATATCAAGAAAGATGTCGCTTACTTGGATCAAATTGGTTCCATGATTGAAGAGCCATCTTATTATCCTAACCTGACTGGTTATGAAAATCTTTTAGTATTTCAAAAAATGCTTAGTTTTGATAAAAATAATATTTGGCCAACGCTGGAACTTGTCGGATTAGCAGATGAGAAAAACACGAAGAAACTTGTTAAAGCCTATTCCCTAGGAATGAAGCAACGCTTAGCTTTAGCGTTTGCATTGGTGAAAAGGCCAAAAATCTTACTGTTGGATGAACCAACTAATGGTCTGGATCCTGCAGGTATTCATGAGATTCGGGAGTTGATTGTAACACTGGCGAAAGAGAAGGGGCTGACAGTATTTATTTCTAGCCATATCTTGTCTGAGATTGAGCATATTGCAGATCGTGTGGGCATTATTAACCACGGTCGTCTCGTCTATGAGGGAGCGATTGAAGCGATTCAGTCCAATGCTTGGATTGAGATTGGCGGCGATTTTTCAACAGGCGATATCACGACAGCTCTAAATGAATATGGATTAGTTAGGGTTCTTGATATAGCAGCCAATAAATTAACCTTGGGCGATTTTTCCAATAACGACTTAGCAGACTTTGTCACCTATTTGGTAGAAAAAGGCTTTCGCATTTTTAGAGTTGTTCGTGAGACAGAGACTCTTGAAGACATTTTCCTTAATTTAACAACGGAGGTTTGA","4.90","-8.78","33492","MDNVIELQNLTKVYNGVTTVDLKKITVHQGEIYGFLGPNGAGKTTTMKMILSLIAPTSGNVLVNDSNIKKDVAYLDQIGSMIEEPSYYPNLTGYENLLVFQKMLSFDKNNIWPTLELVGLADEKNTKKLVKAYSLGMKQRLALAFALVKRPKILLLDEPTNGLDPAGIHEIRELIVTLAKEKGLTVFISSHILSEIEHIADRVGIINHGRLVYEGAIEAIQSNAWIEIGGDFSTGDITTALNEYGLVRVLDIAANKLTLGDFSNNDLADFVTYLVEKGFRIFRVVRETETLEDIFLNLTTEV","1709289","For other components see SMu1648 (MSD1) and SMu1647 (MSD2).For other 'scn' genes see SMu1048 (scnR); SMu1647 (scnG);SMu1648 (scnE) ; SMu1652 (scnK) and SMu1653 (scnR).","cdd4-like bacteriocin component, ScnF homolog","Cytoplasm, Membrane","Matches in gapped BLAST to cdd4-like scnF homologs. Residues 1-295 are 72% similar to gi7445866 from S.pyogenes. Residues 1-298 are 43% similar to gi7445803 from C.difficile.Similar to a mutF from a mutacinII strain (GI:4322366).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1980 (4e-30).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[133-175]T$	ABC_transporter
PF00005	$\"[30-209]T$	ABC_tran
PS50893	$\"[5-233]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[29-210]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-224]T$	G3DSA:3.40.50.300
PTHR19222	$\"[5-223]T$	PTHR19222
PTHR19222:SF16	$\"[5-223]T$	PTHR19222:SF16
SSF52540	$\"[4-223]T$	SSF52540

","BeTs to 10 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1131 is AmTKy-VCEBR-uJ-pol--xNumber of proteins in this genome belonging to this COG is 14","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.2e-20. IPB001140A 19-65 IPB001140B 130-168 IPB001140C 185-214","Residues 78-130 are 84% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME) protein domain (PD342138) which is seen in O31054_STRPY.Residues 180-217 are 65% similar to a (ATP-BINDING TRANSPORTER COMPLETE PROTEOME) protein domain (PD000174) which is seen in O31054_STRPY.Residues 25-221 are 22% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 88-212 are 28% similar to a (LACF) protein domain (PD194047) which is seen in Q9RAV2_LACLA.Residues 218-295 are 56% similar to a (SCNF) protein domain (PD057883) which is seen in O31054_STRPY.Residues 25-68 are 75% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in O31054_STRPY.Residues 133-175 are 97% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O31054_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue May 3 12:42:46 2005","Tue Mar 5 12:29:34 2002","Tue May 3 12:42:46 2005","Wed Apr 10 16:54:26 2002","Tue Mar 5 12:26:30 2002","Tue Mar 5 12:26:30 2002","yes","Mon Oct 21 15:22:25 2002","SMu1649 is paralogously related (blast p-value < 1e-3) to SMu1050, SMu0596, SMu0944, SMu0335, SMu0950, SMu1003, SMu0976, SMu0666, SMu1518, SMu1410, SMu0216, SMu0374, SMu1093, SMu1762, SMu0418, SMu1023, SMu0517, SMu0390, SMu1210, SMu0218, SMu1920, SMu0884, SMu1079, SMu1517, SMu0731, SMu1949, SMu1380, SMu1950, SMu1428, SMu0235, SMu0849, SMu1316, SMu1068, SMu0594, SMu1751, SMu1036, SMu0971, SMu0786, SMu1288, SMu0805, SMu1811, SMu1246, SMu1231, SMu0916, SMu0825, SMu1001, SMu0907, SMu1710, SMu0164, SMu0752, SMu0258, SMu0234, SMu1757, SMu1037, SMu0987, SMu0224, SMu0476, SMu1545, SMu0475, SMu0986, SMu1064, SMu1959, SMu0837, SMu1065, SMu0836, SMu0824, SMu1724, SMu1306, SMu0024, SMu0823, and SMu0729, all ATP-binding proteins.","Tue Mar 5 12:30:26 2002","Tue May 3 12:42:46 2005","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 98 2e-021pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 74 3e-014","SMU.1811c","","Residues 30 to 209 (E-value = 6.5e-49) place SMu1649 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Mar 5 12:26:30 2002","","","Bekal-Si Ali S, Hurtubise Y, Lavoie MC, LaPointe G. Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes.Gene. 2002 Jan 23;283(1-2):125-31.PMID: 11867219 ","","Tue May 3 12:42:46 2005","","1","","","SMU.1811c","" "SMu1650","1710468","1711718","1251","ATGAGACTTATTAAGAATACCACAGAATTAATCGGAATTAAAGACCCAAATATCATTATTTTTCTTGTTTTTGAAACTGATACTCATATCGAGAGTCAAGCAAAACGCAATTATCCTGCACCATCATGCCCTCATTGCCAAGGAAAGATGATCAAATACGACTTTCAAAGACCTTCTAAAATTCCTCTTCTCGAGCAAGCTGGAACTCCAACACTACTACGTCTTAAGAAGCGTCGTTTCCAGTGTAAAGGGTGTAAGAGAGTAATGGTGGCTGAGACATCAATCGTTGAGAAAAACTGCCAAATCTCAAATCTTGTCCGACAAAAAGTTGCACAACGCCTAACTGAGAAGGTATCACTAACTGATATTGCCAGAAGACTTCGTGTGTCAACGTCCACTGTCTATCGTAAACTTGACCAGTTTACCTTCAAGGAACATTATGACAGACTCCCAAGGGTTATGTCCTGGGATGAAGTTGGTTTCAAGAAAGGTGAGTTGGCTTTTGTAGCTCAGAATTATGAGACAAACGAACTCATAACTATCCTTGATAATCGTCGTCAAACAACCATCCGTAATTACTTTTTGAAGTATCCATTAAAAGTTCGACAAGAGGTTCGATTTATCACAATGGATATGTCTGGGGCTTATATTCCAATGGCTCGCAAACTCTTTCCAAACGCCAAAATCGTTCTTGACAGATTTCACATTATCCAGCACCTTGGACGTGCCTTTTTAAAGACAAGAATTGCAATTATGAACCAGTTTGATAAGAAGTCGCTACCCTATCGAGCCTTGAAAAATCACTGGCGACTCTTTCAAAAGGACAGCCGTAAGTTATCTCTCAACTCTTTTTATTCAAAGACCTTCCGTCAAACCTTAAGTCCACATGAAGTCGTTGAGAAGACACTAGACTTTTCAGAAGAGCTTACCGACTACTATACTCTTTACCAGCTTTTACTTTTTCACTTTCAAGAGAAGAGAGCGGAGGAGTTTTTCGAACTCATAGAAGAAAATATGAGCAAGGTCAATCATTACTTTCAAATTATCTTTAGGACCTTTCTTAAACACAAACAATACATCAAAAACGCACTAGAAACGGACTATTCAAACGCAAAACTTGAAGCTACTAACAAGTTGATTAAAGACATCAAACGTTTGGGATTTGGTTTTAGAAACTTTATCAACTTTAGAAAGCGTGTGTTCATCACCCTGAACATCCAAAAAAAAGAAGATCTATCCGGTCCTCTCTAG","10.70","34.19","49547","MRLIKNTTELIGIKDPNIIIFLVFETDTHIESQAKRNYPAPSCPHCQGKMIKYDFQRPSKIPLLEQAGTPTLLRLKKRRFQCKGCKRVMVAETSIVEKNCQISNLVRQKVAQRLTEKVSLTDIARRLRVSTSTVYRKLDQFTFKEHYDRLPRVMSWDEVGFKKGELAFVAQNYETNELITILDNRRQTTIRNYFLKYPLKVRQEVRFITMDMSGAYIPMARKLFPNAKIVLDRFHIIQHLGRAFLKTRIAIMNQFDKKSLPYRALKNHWRLFQKDSRKLSLNSFYSKTFRQTLSPHEVVEKTLDFSEELTDYYTLYQLLLFHFQEKRAEEFFELIEENMSKVNHYFQIIFRTFLKHKQYIKNALETDYSNAKLEATNKLIKDIKRLGFGFRNFINFRKRVFITLNIQKKEDLSGPL","1711728","","transposase, IS1193n-related","Cytoplasm, Extracellular","Matches in gapped BLAST to IS1167 transposases. Residues 1-409 are 87% similar to gi14389024 from S.thermophilus. Residues 11-409 are 87% similar to gi11595699 from S.salivarius.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2022 (3e-13).","

InterPro
IPR000843
Domain

Bacterial regulatory protein, LacI
PF00356	$\"[118-143]T$	LacI

InterPro
IPR002560
Family

Transposase, IS204/IS1001/IS1096/IS1165
PF01610	$\"[153-251]T$	Transposase_12

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[102-141]T$	Homeodomain_like

","No hits to the COGs database.","***** IPB001598 (Transposases IS30 family) with a combined E-value of 1.7e-06. IPB001598A 101-136 IPB001598E 361-393","Residues 157-243 are 90% similar to a (TRANSPOSASE COMPLETE PROTEOME PLASMID) protein domain (PD003298) which is seen in Q9EVW8_STRSL.Residues 244-280 are identical to a (TRANSPOSASE ATCC PLASMID) protein domain (PD327821) which is seen in O86927_STRTR.Residues 11-156 are 88% similar to a (TRANSPOSASE ATCC INSERTION PLASMID) protein domain (PD007476) which is seen in Q9EVW8_STRSL.Residues 283-402 are 80% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD079423) which is seen in O86927_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 12:35:33 2002","Tue Sep 26 16:20:11 2006","Tue Sep 5 08:48:34 2006","Tue Mar 5 12:31:11 2002","Tue Mar 5 12:31:11 2002","Tue Mar 5 12:31:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1650 is paralogously related (blast p-value < 1e-3) to SMu1215, SMu1216, and SMu1214, all predicted transposases.","Tue Mar 5 12:36:41 2002","","No significant hits to the NCBI PDB database.","SMU.1812","","Residues 30 to 363 (E-value = 1.2e-98) place SMu1650 in the Transposase_12 family which is described as Transposase (PF01610)","Tue Mar 5 12:31:11 2002","24380176","","","Coffey,T.J., Enright,M.C., Daniels,M., Morona,J.K., Morona,R.,Hryniewicz,W., Paton,J.C. and Spratt,B.G.Recombinational exchanges at the capsular polysaccharidebiosynthetic locus lead to frequent serotype changes among naturalisolates of Streptococcus pneumoniaeMol. Microbiol. 27 (1), 73-83 (1998)PubMed: 9466257","","Tue Mar 5 12:35:33 2002","1","","","SMU.1812","1024" "SMu1651","1712141","1712251","111","ATGCCAATGACTTACTGCGGAAGTCCTAGGAGAACAGACTTAGCAGTAATCACAGATGAGGAACTAGGACAGACTTTAGAGGTTATTAATCATTGGCCACGCAATGTTTAG","4.80","-1.83","4126","MPMTYCGSPRRTDLAVITDEELGQTLEVINHWPRNV","1712261","","hypothetical protein, probable transposase fragment","Periplasm, Cytoplasm","No significant hits in gapped BLAST.SMu1651 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 16:28:18 2002","Tue Mar 5 12:38:23 2002","Tue Oct 8 16:28:18 2002","Tue Mar 5 12:38:23 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1651 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 16:28:18 2002","","No significant hits to the NCBI PDB database.","SMU.1813","","No significant hits to the Pfam 11.0 database","Tue Mar 5 12:38:23 2002","24380177","","","","","","1","","","SMU.1813","" "SMu1652","1713683","1712304","1380","ATGAATATTTTAAAAAGGAGTGCCCTAAGATTTGTCTTTTTCTTTATCTTAGTTTTACTTCTCAATATCGTCTTTGTACTAGCTGCTATGGCCTACGTCAATAGTCAACAATACCCCCCTGATACTTCTGAAACCATAGCTTCTGAGATCACTTTATCTGATGGCAGCTATCATGTTAGTCCTAAAGCCAAACGGCTGATTTCACAAGAAAAGCTGTGGGTCATGATTATTGACAAAAACACAGGTCGGGAGATCTTCAATATCAATAAACCCCAGCAGATTGGAACGCACTTTAACTATGCAGATGTTGTTAGATTTTCCCGATTTTACTTACATGATTACCCTGTCTTTACTCGGATAAAAGATGACGAAAATGCTATTTATATTGTGGCTTTTCCAAAAGACAGTATTATCCGATATAGCTACAATTTCCTAGAATCACATAGGTATCGTTTCATTCCTATCTTGGCTCTTGGTATAATCTCTATCAATGTCTTGTTGTGCTTGTTTCTCTACATTTACAGTGTCACCTTTCTCAATCGTAATATTAGGCCTATTATCAATGCCATTGGGAAGTTACCTAGTGGTTTAAATACACAAGTTAATTCTGTTAAAGAATTAGATCGATTGGCACTGGCAGTCAACTCTGCCAACCAACAACTTCGAGAAAATGAAGAATTTAAAGAAAACTGGATATCAGGTATTGCTCATGATATTAAAACCCCCCTCTCCGTTATCGTGTCTAATACATCATTAGCCATTGAAAAGACTGACAACGAAAGCCTTCTTAAGCACCTAAATCCTACTCTGGTTGAAAGTCACTACATTCAAAATCTACTAAACGACCTCAATATATTTGCTCGATTGACAAATGGTAACTTAGAGTTAAAAAAAGAAATAGTTACCATCATTCCTTTCTTTAAGGAAATTATAATTCAAATTGTCAACCAAGATGTTTGGGAAGAATTTCAGTTTGAATTTGATGCAGAATCCAACTTATCAGGTAAGAAAATGTATGTCGAGAAAGCCCTCATTTCTCGTGTTATTCATAATTTGATTTATAATTCTGTCCTCCATAATAGTCATGGCTGTACGATAAAAATTGAACTTAAATCCTATTCAGATGATAATTTTAAAATTACTGTACAGGATAATGGTGTAGGAACATCTCTAGAAAAACTGAAAAATATCAATAAAATAGAAGAATTTACTTTTGACATCTCTGGCGTTAGAAGAAGCGGTATGGGCTTGAAAATATCTAAACAAATCATTGATTTGCATAATGGTGATATGATTATCAAAAGTGAACAAGGCAGGTATTTTAAAACGGACATTATACTACCAATAGCATTTACTTCTGGTTCAGACAATCCTCTATGA","7.70","2.58","52613","MNILKRSALRFVFFFILVLLLNIVFVLAAMAYVNSQQYPPDTSETIASEITLSDGSYHVSPKAKRLISQEKLWVMIIDKNTGREIFNINKPQQIGTHFNYADVVRFSRFYLHDYPVFTRIKDDENAIYIVAFPKDSIIRYSYNFLESHRYRFIPILALGIISINVLLCLFLYIYSVTFLNRNIRPIINAIGKLPSGLNTQVNSVKELDRLALAVNSANQQLRENEEFKENWISGIAHDIKTPLSVIVSNTSLAIEKTDNESLLKHLNPTLVESHYIQNLLNDLNIFARLTNGNLELKKEIVTIIPFFKEIIIQIVNQDVWEEFQFEFDAESNLSGKKMYVEKALISRVIHNLIYNSVLHNSHGCTIKIELKSYSDDNFKITVQDNGVGTSLEKLKNINKIEEFTFDISGVRRSGMGLKISKQIIDLHNGDMIIKSEQGRYFKTDIILPIAFTSGSDNPL","1712320","For other 'scn' genes see SMu1048 (scnR); SMu1647 (scnG);SMu1648 (scnE) ; SMu1649 (scnF) and SMu1653 (scnR).","histidine kinase, ScnK homolog","Membrane, Cytoplasm","Matches in gapped BLAST to histidine kinases and sensory transduction elements. Residues 1-449 are 66% similar to gi|7474192 from S.pyogenes. Residues 36-449 are 28% similar to gi|8250638 from R.gnavus (RumK protein).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1624 (9e-13).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[298-457]T$	ATP_bd_ATPase
PF02518	$\"[340-450]T$	HATPase_c
SM00387	$\"[340-451]T$	HATPase_c
SSF55874	$\"[281-449]T$	ATP_bd_ATPase

InterPro
IPR003661
Domain

Histidine kinase A, N-terminal
PF00512	$\"[227-292]T$	HisKA
SM00388	$\"[227-292]T$	HisKA

InterPro
IPR004358
Domain

Histidine kinase related protein, C-terminal
PR00344	$\"[378-392]T$ $\"[411-429]T$	BCTRLSENSOR

InterPro
IPR005467
Domain

Histidine kinase
PS50109	$\"[234-451]T$	HIS_KIN

InterPro
IPR009082
Domain

Histidine kinase, homodimeric
SSF47384	$\"[217-288]T$	His_kin_homodim

noIPR
unintegrated

unintegrated
PTHR23283	$\"[16-449]T$	PTHR23283
PTHR23283:SF26	$\"[16-449]T$	PTHR23283:SF26

","BeTs to 13 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 341-399 are 38% similar to a (TRANSDUCTION TRANSFERASE PHOSPHORYLATION) protein domain (PD088708) which is seen in Q9L3F2_BBBBB.Residues 347-449 are 73% similar to a (KINASE COMPLETE PROTEOME HISTIDINE) protein domain (PD088883) which is seen in O31049_STRPY.Residues 29-207 are 66% similar to a (TRANSFERASE PHOSPHORYLATION KINASE) protein domain (PD088886) which is seen in O31049_STRPY.Residues 323-431 are 34% similar to a (KINASE TRANSDUCTION TRANSFERASE) protein domain (PD125954) which is seen in Q9PPC6_CAMJE.Residues 212-299 are 88% similar to a (KINASE SENSORY TRANSDUCTION PHOSPHORYLATION TRANSFERASE) protein domain (PD000142) which is seen in O31049_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 11:26:11 2002","Tue Mar 5 12:39:15 2002","Wed Oct 16 09:43:14 2002","Wed Apr 10 16:44:53 2002","","Tue Jan 8 12:02:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1652 is paralogously related (blast p-value < 1e-3) to SMu1047, SMu0602, SMu1378, SMu1031, SMu0946, SMu0842, all predicted histidine kinases, and to SMu0041, a hypothetical.","Tue Mar 5 12:44:14 2002","","No significant hits to the NCBI PDB database.","SMU.1814c","","Residues 227 to 292 (E-value = 1.4e-11) place SMu1652 in the HisKA family which is described as His Kinase A (phosphoacceptor) domain (PF00512)Residues 340 to 450 (E-value = 5.2e-15) place SMu1652 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Tue Jan 8 12:02:55 2002","","","","","","","1","","","SMU.1814c","" "SMu1653","1714399","1713701","699","GTGTCTTTTGAATCACAATTATTGAAAAAGCATATCCTAATCGTAGATGATGATACATCATTGAACCAGTCCATCAAAGAGGTTTTGATGAGTCGAGGGTTTAACAATATCAGTTCTGCCTATAGTATAGATGAAGGGATTGATATTTTTTCGGTATCAAAGATTGATTTGATCATACTGGATGTCATGTTGCCCGATGGGGAAGGTTATTTATTGGCCAAATACATTCGAAAATCGTCAGATGTCCCCATTTTATTTTTAACCGCAAAAAATAGTCCCGATGATGAAATCAAAGGACTTGATTCAGGAGGAGATGATTTTGTCACCAAACCATTTCTTCCCAAGACCCTGTCTTATAGGATTATAGCCTTACTGAGGCGATCCTACAAAGGTGAATCTGAACTTATCGAACTTACTTTCTGCACCATTGATTTAAATAATGCCAGTGTTTTAAAAGGCAATGAACATCTATCACTGACCCCAACAGAAATTCAGATTCTTCGCAAACTTTATGTCAATAAAAACCACATCGTCTCCACAGAAGCGATTTGCGATGCGGTGTGGGGACTTGAAAACTTTGGATACGAAAAATCATTAATGGTACATATCCGCAATATCAGAGAAAAAATCGAGAAAAACTCCTCAAAGCCAGTGCATCTCATTACAGTCAAGGGTCTCGGGTATAAGCTGGTTATTTAG","6.40","-1.89","26059","MSFESQLLKKHILIVDDDTSLNQSIKEVLMSRGFNNISSAYSIDEGIDIFSVSKIDLIILDVMLPDGEGYLLAKYIRKSSDVPILFLTAKNSPDDEIKGLDSGGDDFVTKPFLPKTLSYRIIALLRRSYKGESELIELTFCTIDLNNASVLKGNEHLSLTPTEIQILRKLYVNKNHIVSTEAICDAVWGLENFGYEKSLMVHIRNIREKIEKNSSKPVHLITVKGLGYKLVI","1713717","For other 'scn' genes see SMu1048 (scnR); SMu1647 (scnG);SMu1648 (scnE) ; SMu1649 (scnF) and SMu1652 (scnK).","response regulator, ScnR homolog","Cytoplasm","Matches in gapped BLAST to ScnR-related proteins. Residues 1-232 are 82% similar to gi|7444059 from S.pyogenes. Residues 5-230 are 47% similar to gi|8250637 from R.gnavus (RumR protein).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0719 (2e-33).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[11-126]T$	Q8DSH0_STRMU_Q8DSH0;
PF00072	$\"[10-122]T$	Response_reg
SM00448	$\"[10-121]T$	REC
PS50110	$\"[11-125]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[142-231]T$	Q8DSH0_STRMU_Q8DSH0;
PF00486	$\"[154-230]T$	Trans_reg_C

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[128-230]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[11-127]T$	no description
PTHR23283	$\"[9-130]T$	SENSOR HISTIDINE KINASE-RELATED
PTHR23283:SF21	$\"[9-130]T$	TWO-COMPONENT SYSTEM SENSOR HISTIDINE KINASE/RESPONSE REGULATOR (INTESTINAL BACTERIA - BACTEROIDES THETAIOTAOMICRON)

InterPro
IPR013597
Domain

Group II intron, maturase-specific
PF08388	$\"[1-42]T$	GIIM

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-77 are 84% similar to a (POLYMERASE RNA-DIRECTED DNA PLASMID) protein domain (PD036246) which is seen in O52231_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 09:40:01 2002","Tue Sep 26 16:36:05 2006","Mon Sep 25 18:10:32 2006","Tue Mar 5 12:54:42 2002","","Tue Mar 5 12:54:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1654 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 09:40:01 2002","","No significant hits to the NCBI PDB database.","SMU.1816c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 12:54:42 2002","24380180","","","","","","1","","","SMU.1816c","" "SMu1655","1715277","1715071","207","ATGTCTCTTGTTCATCATATTATCCAAGATGGCGATACAGAGTCCTTCATTCGTAGCTATCTCTACTCGGGTGTGGTCATTAATGGACAACGACATAAAACGTTAGCAGGAACTCCCCAAAGAGGGAACCTATCACCACTCTTATCCAACATTATGATTAATGAGTTGGATAAGGAATTGGAAAATAGGGATCTACACTTTGTCTGA","6.50","-1.06","7715","MSLVHHIIQDGDTESFIRSYLYSGVVINGQRHKTLAGTPQRGNLSPLLSNIMINELDKELENRDLHFV","1715087","","transposon-related, maturase-related protein fragment","Cytoplasm, Extracellular","Matches in gapped BLAST to transposases and maturase-related proteins. Residues 1-68 are 80% similar to gi15904025 from S.pneumoniae and 82% similar to gi16588995 from S.agalactiae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1235 (3e-28).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-68 are 80% similar to a (DNA RNA-DIRECTED POLYMERASE MITOCHONDRION) protein domain (PD002285) which is seen in O52231_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 09:39:23 2002","Tue Sep 26 16:39:01 2006","Mon Sep 25 18:09:41 2006","Tue Mar 5 12:57:38 2002","","Tue Mar 5 12:57:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1655 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 09:39:23 2002","","No significant hits to the NCBI PDB database.","SMU.1817c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 12:57:38 2002","24380181","","","","","","1","","","SMU.1817c","" "SMu1656","1715749","1715576","174","TTGTATCGCTGGATTCAAGAATACGAAAAATATGGAGAAAGAGCGTTCCCAGGACAAGGGAGCGCTCTTCGTCATGCCCAATTTGAACTTAAAAAACTCGAAAAAGAAAATAAGATATTACAAGAGGAGTTAGCTCTCCGTGGTAGCGTCCGAATCACTCAAGAACTCTATTGA","9.20","1.23","6838","MYRWIQEYEKYGERAFPGQGSALRHAQFELKKLEKENKILQEELALRGSVRITQELY","1715592","","hypothetical protein","Cytoplasm","A single weak match in gapped BLAST to gi|15674397 from S.pyogenes. Residues 1-28 are 89% similar to this sequence.SMu1656 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 5 13:00:08 2002","Tue Mar 5 12:58:27 2002","Tue Mar 5 13:00:08 2002","Tue Mar 5 12:58:27 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1656 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 13:00:08 2002","","No significant hits to the NCBI PDB database.","SMU.1818c","","No significant hits to the Pfam 11.0 database","Tue Mar 5 12:58:27 2002","24380182","","","","","","1","","","SMU.1818c","" "SMu1657","1717441","1716002","1440","ATGAATTTTGAAACTATCATTGGATTAGAAGTCCATGTTGAATTAAAAACAAATTCTAAAATTTTTTCACCTGCACCAGCGCATTTTGGAGAGGATCCAAATGCTAATACGAATATCGTTGACTGGTCATTTCCAGGTGTCTTGCCTGTTATGAATAAGGGTGTTATTGATTATGGCATCAAGGCTGCACTTGCTCTCAATATGGACATTCACCAACGCATGCACTTTGACCGCAAGAATTATTTTTATCCTGATAATCCCAAAGCCTACCAAATTTCACAATTTGATGAACCTATCGGCTACAACGGTTGGATTGAAATTGAATTAGAAGATGGCAGCACCAAGAAAATTCGCATTGAACGCGCTCACTTGGAAGAAGATGCTGGGAAAAATACGCATGGTGCTGATGGTTATTCTTATGTTGACCTCAACCGTCAAGGGGTCCCTTTGATTGAAATCGTATCAGAAGCTGATATGCGTTCACCTGAGGAAGCTTATGCTTATTTAACAGCCCTTAAAGAAATTATCCAATACACAGGAATTTCAGATGTCAAAATGGAAGAAGGCTCCATGCGGGTGGATGCCAACATTTCTATCCGTCCTTATGGACAGGAAGCATTTGGTGTCAAGACTGAGTTGAAAAACTTGAACTCTTTCAATTTTGTTCGTCGCGGTTTGGCCTATGAAGAAAAACGTCAGGCAGAAGTCCTTCGTTCTGGAGGTCAAATTCAGCAAGAAACACGCCGTTATGATGAAGCAACAGGGGAAACCTTGTTAATGCGTGTCAAAGAAGGTTCAGCAGATTATCGCTACTTCCCAGAACCAGATCTACCAATTTTTGAAATTGAAGATGAGTGGATTGAAAAAGTTCGAGCAGAATTACCAGCCTTTCCAAAAGAACGCCGTGCTAAGTATGTCAATGACTTAGGATTGTCGGCTTATGATGCTGCCCAACTGACCAGCTCAAAAGCCATTTCAGATTTCTTTGAGTCAGCTCTTGCTCAAGGTGCAGATGCTAAGGCTGTTTCTAACTGGCTCCAAGGAGACGTGGCACAATATCTCAATACTGAAAATCAAACCATTGATCAAATCGGTTTGACACCTGAAAATTTGACTGAAATGCTTCAGTTAGTAGCAGATGGAACGATCTCTTCTAAAATTGCTAAGAAAGTTTTTGTTCATTTAGCTAAAAATGGCGGTTCTGCCAAAGAATATGTCAAATCGGCTGGTCTTATTCAAATCTCTGATCCAGCACAGCTTCTGCCAATCATCCAAGAAGTCTTTGCCAATAACGAAAAAGCATTGAATGACTACAAAGGCGGCAACAAAAATGCAGCCAAATCTCTAGTTGGTCAAATTATGAAAGCCACAAGAGGACAAGCCAACCCACAAGTCGCGCAAAAATTGCTTAATGAAGAATTGGCAAAATTAACAGATTAA","4.90","-16.25","53491","MNFETIIGLEVHVELKTNSKIFSPAPAHFGEDPNANTNIVDWSFPGVLPVMNKGVIDYGIKAALALNMDIHQRMHFDRKNYFYPDNPKAYQISQFDEPIGYNGWIEIELEDGSTKKIRIERAHLEEDAGKNTHGADGYSYVDLNRQGVPLIEIVSEADMRSPEEAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISIRPYGQEAFGVKTELKNLNSFNFVRRGLAYEEKRQAEVLRSGGQIQQETRRYDEATGETLLMRVKEGSADYRYFPEPDLPIFEIEDEWIEKVRAELPAFPKERRAKYVNDLGLSAYDAAQLTSSKAISDFFESALAQGADAKAVSNWLQGDVAQYLNTENQTIDQIGLTPENLTEMLQLVADGTISSKIAKKVFVHLAKNGGSAKEYVKSAGLIQISDPAQLLPIIQEVFANNEKALNDYKGGNKNAAKSLVGQIMKATRGQANPQVAQKLLNEELAKLTD","1716018","For other 'gat' genes see SMu1123 (gat); SMu1658 (gatA); SMu1659 (gatC) and SMu1660 (gatA).","glutamyl-tRNA (Gln) amidotransferase subunit B","Cytoplasm","Matches in gapped BLAST to Glutamyl tRNA-Gln amidotransferase subunit B sequences. Residues 1-479 are 79% similar to gi15902437 from S.pneumoniae and 79% similar to gi15675614 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1667 (0.0).","

InterPro
IPR003789
Domain

GatB/Yqey
PF02637	$\"[327-474]T$	GatB_Yqey

InterPro
IPR004413
Family

Glutamyl-tRNA(Gln) amidotransferase B subunit
PTHR11659	$\"[11-476]T$	GatB
TIGR00133	$\"[1-475]T$	gatB
PS01234	$\"[143-157]T$	GATB

InterPro
IPR006075
Domain

GatB N-terminal region
PF02934	$\"[1-240]T$	GatB_N

InterPro
IPR006107
Domain

GatB, central region
PF01162	$\"[257-325]T$	GatB

noIPR
unintegrated

unintegrated
SSF89095	$\"[322-475]T$	SSF89095

","BeTs to 16 clades of COG0064COG name: Glu-tRNAGln amidotransferase B subunit (PET112 homolog)Functional Class: JThe phylogenetic pattern of COG0064 is AMTkyqvc-br-ujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001773 (Glutamyl-tRNA(Gln) amidotransferase subunit B) with a combined E-value of 2.1e-117. IPB001773A 7-18 IPB001773B 33-52 IPB001773C 76-94 IPB001773D 115-127 IPB001773E 141-157 IPB001773F 186-199 IPB001773G 210-233 IPB001773H 257-277 IPB001773I 424-463","Residues 287-333 are 44% similar to a (B SUBUNIT 6.3.5.- GLUTAMYL-TRNAGLN) protein domain (PD258002) which is seen in GATB_MORCA.Residues 309-463 are 69% similar to a (SUBUNIT AMIDOTRANSFERASE GLUTAMYL-TRNAGLN) protein domain (PD309942) which is seen in GATB_LACLA.Residues 1-286 are 81% similar to a (SUBUNIT AMIDOTRANSFERASE GLUTAMYL-TRNAGLN) protein domain (PD002690) which is seen in GATB_LACLA.Residues 124-256 are 27% similar to a (PH1464) protein domain (PD397639) which is seen in YE64_PYRHO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 15 10:21:42 2006","Thu May 2 12:43:01 2002","Tue Aug 15 10:21:42 2006","Thu Apr 11 11:19:21 2002","Tue Mar 5 13:01:24 2002","Tue Mar 5 13:01:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1657 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 13:04:03 2002","","No significant hits to the NCBI PDB database.","SMU.1819c","","Residues 1 to 240 (E-value = 5.6e-145) place SMu1657 in the GatB_N family which is described as PET112 family, N terminal region (PF02934)Residues 257 to 325 (E-value = 2.9e-33) place SMu1657 in the GatB family which is described as PET112 family, C terminal region (PF01162)Residues 327 to 474 (E-value = 4.3e-51) place SMu1657 in the GatB_Yqey family which is described as GatB/Yqey domain (PF02637)","Tue Aug 15 10:21:42 2006","","","","Curnow AW, Hong K, Yuan R, Kim S, Martins O, Winkler W, Henkin TM, Soll D.Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11819-26.PMID: 9342321 ","","Tue Mar 5 13:06:49 2002","1","","","SMU.1819c","168" "SMu1658","1718907","1717441","1467","ATGACTTTTAATCATAAATCCATTGATGAATTGCATGACCTTCTTGTTAATAAGGAAGTTTCAGCGCTAGAATTAACCAAGGCTACTTTAGAAGATATCAAGGAACGTGAAGAAACAGTAGGTTCTTTTATCACTGTAACACAAGAAGAAGCATTAGCACAGGCTGCTGCTATTGATGAAAAGGGAATTGATGCAGATAATGTTATGTCGGGGATTCCTTTGGCAGTCAAGGACAATATTTCGACCAAAAATATCTTAACAACTGCTGCCTCAAAAATGCTTTATAACTATAAACCTATCTTTGATGCCACTTCTGTTGAAAAGCTTTATGGCAGGGATATGATTATTGTCGGTAAAACCAATATGGATGAATTTGCCATGGGTGGTTCTACTGAAAACTCCTATTTCAAGTTGACTAAAAATGCTTGGAATCAAGAGAAAGTAGCTGGTGGTTCTTCAGGCGGTTCTGCAACAGCAGTCGCTTCTGGTCAGGTACGTTTGTCACTTGGTTCTGATACAGGTGGTTCTATTCGTCAACCTGCTGCTTTTAATGGTGTCGTTGGAATCAAGCCAACTTACGGTCGTGTATCACGTTTTGGTTTGATTGCTTTTGGTTCTTCATTGGATCAAATTGGGCCATTCTCACAAACGGTTAAAGAAAATGCCCAATTGCTTAATGTTATTTCAGGAAATGATAAGAAAGATTCAACCTCTTCACAAGTAAAAGTACCTGATTTTACGCAGTTCATTGGTAAGGACATCAAGGGAATGAAAATTGCCCTTCCTAAAGAATATATTGGTCAAGGAATTGATGAAAAGGTCAAGGAAACGATTCTGAAAGCTGCTAAGCATCTAGAAAGCTTAGGCGCTATCGTTGAAGAAGTTAGTCTGCCACACAGTAAATACGGTGTTGCCGTTTACTATATTATTGCTTCATCGGAAGCCTCTTCAAACTTGCAACGTTTCGATGGCATTCGCTATGGCTATCGCACCGACGATTATGAAAATCTGGATGATGTCTATGTCAACACCCGCAGTGAAGGTTTTGGCGAAGAAGTAAAACGTCGTATTATGCTGGGAACTTTCAGTCTTTCTTCAGGTTATTATGATGCCTATTTCAAAAAAGCTGGTCAAGTACGAACACTTATCATGGAAGATTTCAAGAAGGTTTTTGCCAACTACGATTTAATTTTAGGTCCAACAGCACCAACTGTTGCTTATGATTTGGATTCGCAACACCAAGATCCTGTTGCTATGTATTTAGCTGACTTGTTAACTATTCCAGTAAACTTAGCTGGTCTGCCAGGCATCTCTATACCTGCTGGTTTTGTGGAAGGATTGCCTGTTGGTATGCAACTAATTGGAAAACCATTTGCTGAGCAAACCATCTATCAAGCAGCGGCAGCTTTTGAAGCAAGTACGGATTATCATAAACAACAACCAGTTATTTTTGGAGGTGGCAACTAA","5.00","-10.52","52882","MTFNHKSIDELHDLLVNKEVSALELTKATLEDIKEREETVGSFITVTQEEALAQAAAIDEKGIDADNVMSGIPLAVKDNISTKNILTTAASKMLYNYKPIFDATSVEKLYGRDMIIVGKTNMDEFAMGGSTENSYFKLTKNAWNQEKVAGGSSGGSATAVASGQVRLSLGSDTGGSIRQPAAFNGVVGIKPTYGRVSRFGLIAFGSSLDQIGPFSQTVKENAQLLNVISGNDKKDSTSSQVKVPDFTQFIGKDIKGMKIALPKEYIGQGIDEKVKETILKAAKHLESLGAIVEEVSLPHSKYGVAVYYIIASSEASSNLQRFDGIRYGYRTDDYENLDDVYVNTRSEGFGEEVKRRIMLGTFSLSSGYYDAYFKKAGQVRTLIMEDFKKVFANYDLILGPTAPTVAYDLDSQHQDPVAMYLADLLTIPVNLAGLPGISIPAGFVEGLPVGMQLIGKPFAEQTIYQAAAAFEASTDYHKQQPVIFGGGN","1717457","For other 'gat' genes see SMu1123 (gat); SMu1657 (gatB); SMu1659 (gatC) and SMu1660 (gatA).","glutamyl-tRNA(Gln) amidotransferase subunit A","Cytoplasm","Matches in gapped BLAST to glutamyl-tRNA(Gln) amidotransferase, A subunit sequences. Residues 1-486 are 78% similar to gi15675615 from S.pyogenes. Residues 1-488 are 77% similar to gi15900355 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1668 (0.0).","

InterPro
IPR000120
Family

Amidase
PTHR11895	$\"[16-483]T$	Amidase
PF01425	$\"[24-464]T$	Amidase
PS00571	$\"[150-181]T$	AMIDASES

InterPro
IPR004412
Family

Glutamyl-tRNA(Gln) amidotransferase A subunit
TIGR00132	$\"[11-476]T$	gatA

noIPR
unintegrated

unintegrated
G3DSA:3.90.1300.10	$\"[2-481]T$	G3DSA:3.90.1300.10
PTHR11895:SF7	$\"[16-483]T$	PTHR11895:SF7
SSF75304	$\"[1-475]T$	SSF75304

","BeTs to 15 clades of COG0154COG name: Glu-tRNAGln amidotransferase A subunit (amidase)Functional Class: JThe phylogenetic pattern of COG0154 is Amt-YqvC-bR-ujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000120 (Amidase) with a combined E-value of 1.3e-33. IPB000120 141-194","Residues 385-471 are 41% similar to a (AMIDASE HYDROLASE) protein domain (PD407270) which is seen in AMID_PSECL.Residues 397-467 are 45% similar to a (SUBUNIT AMIDOTRANSFERASE 6.3.5.-) protein domain (PD247831) which is seen in GATA_TREPA.Residues 306-440 are 33% similar to a (SUBUNIT AMIDOTRANSFERASE GLUTAMYL-TRNAGLN) protein domain (PD038941) which is seen in Q9PPU5_UREPA.Residues 395-471 are 48% similar to a (A PROTEOME GLU-TRNAGLN SUBUNIT) protein domain (PD391148) which is seen in Q9PNN2_CAMJE.Residues 389-481 are 35% similar to a (PROTEOME COMPLETE AMIDASE) protein domain (PD354096) which is seen in Q9HW59_PSEAE.Residues 349-470 are 76% similar to a (SUBUNIT AMIDOTRANSFERASE GLUTAMYL-TRNAGLN 6.3.5.-) protein domain (PD002554) which is seen in GATA_LACLA.Residues 270-348 are 86% similar to a (SUBUNIT AMIDOTRANSFERASE GLUTAMYL-TRNAGLN) protein domain (PD343710) which is seen in GATA_LACLA.Residues 350-463 are 29% similar to a (SUBUNIT 6.3.5.- GLUTAMYL-TRNAGLN GLU-ADT) protein domain (PD302448) which is seen in GATH_YEAST.Residues 349-391 are 62% similar to a (SUBUNIT AMIDOTRANSFERASE 6.3.5.-) protein domain (PD362640) which is seen in GATA_MORCA.Residues 122-265 are 75% similar to a (HYDROLASE SUBUNIT AMIDOTRANSFERASE BIOSYNTHESIS AMIDASE) protein domain (PD038838) which is seen in GATA_LACLA.Residues 6-121 are 56% similar to a (HYDROLASE SUBUNIT AMIDOTRANSFERASE BIOSYNTHESIS) protein domain (PD001110) which is seen in GATA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 15 10:26:55 2006","Thu May 2 12:43:45 2002","Tue Aug 15 10:26:55 2006","Thu Apr 11 11:19:49 2002","Tue Mar 5 13:07:35 2002","Tue Mar 5 13:07:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1658 is paralogously related (blast p-value < 1e-3) to SMu1113.","Tue Mar 5 13:08:36 2002","","No significant hits to the NCBI PDB database.","SMU.1820c","","Residues 24 to 464 (E-value = 2.1e-187) place SMu1658 in the Amidase family which is described as Amidase (PF01425)","Tue Mar 5 13:07:35 2002","24380184","","","Curnow AW, Hong K, Yuan R, Kim S, Martins O, Winkler W, Henkin TM, Soll D.Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11819-26.PMID: 9342321 ","","Tue Mar 5 13:08:36 2002","1","","","SMU.1820c","169" "SMu1659","1719209","1718907","303","ATGAAAATTTCCGAAGAAGAAGTTCGCCATGTGGCTAACCTTTCTAAGTTAAAATTCTCAGATGATGAAACAACAGAATTTGCAACAACTTTGACTAAGATTGTTGATATGGTGGAATTACTAAATGAAGTTGATACGCAAGGTGTTCCTTTTACATCAAATGTCGCAGATAATATTAATTATATGCGAGAAGATGTTTCTGTAGCAGGTTGGGATCGTGAACAACTCTTTAAAAATGTTCCTGAACACGAAGATGGTCTGATTAAAGTGCCAGCTATCATTGATGAAGGAGGAGATGCCTAA","4.10","-12.52","11194","MKISEEEVRHVANLSKLKFSDDETTEFATTLTKIVDMVELLNEVDTQGVPFTSNVADNINYMREDVSVAGWDREQLFKNVPEHEDGLIKVPAIIDEGGDA","1718923","For other 'gat' genes see SMu1123 (gat); SMu1657 (gatB); SMu1658 (gatA) and SMu1660 (gatA).","glutamyl-tRNA (Gln) amidotransferase subunit C","Cytoplasm","Matches in gapped BLAST to Glu-tRNA Gln amidotransferase subunit C sequences. Residues 1-100 are 72% similar to gi15675616 from S.pyogenes. Residues 2-100 are 62% similar to gi15672144 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1669 (6e-37).","

InterPro
IPR003837
Family

Glu-tRNAGln amidotransferase, C subunit
PF02686	$\"[19-90]T$	Glu-tRNAGln
TIGR00135	$\"[3-95]T$	gatC

","BeTs to 8 clades of COG0721COG name: Glu-tRNAGln amidotransferase C subunitFunctional Class: JThe phylogenetic pattern of COG0721 is amt--qvc-br-ujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003837 (Glu-tRNAGln amidotransferase C subunit) with a combined E-value of 3.3e-09. IPB003837A 12-34 IPB003837B 40-52 IPB003837C 63-79","Residues 3-94 are 27% similar to a (SUBUNIT 6.3.5.- GLUTAMYL-TRNAGLN GLU-ADT) protein domain (PD172635) which is seen in GATC_CHLPN.Residues 3-91 are 64% similar to a (SUBUNIT AMIDOTRANSFERASE GLUTAMYL-TRNAGLN) protein domain (PD009162) which is seen in GATC_LACLA.Residues 3-89 are 33% similar to a (C SUBUNIT 6.3.5.- GLUTAMYL-TRNAGLN) protein domain (PD284293) which is seen in GATC_RICPR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 10:21:53 2006","Tue Mar 5 13:13:02 2002","Tue Sep 19 10:21:53 2006","Thu Apr 11 11:20:19 2002","Tue Mar 5 13:13:02 2002","Tue Mar 5 13:13:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1659 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Mar 5 13:14:02 2002","","No significant hits to the NCBI PDB database.","SMU.1821c","","Residues 19 to 90 (E-value = 1.9e-20) place SMu1659 in the Glu-tRNAGln family which is described as Glu-tRNAGln amidotransferase C subunit (PF02686)","Tue Mar 5 13:13:02 2002","24380185","","","Curnow AW, Hong K, Yuan R, Kim S, Martins O, Winkler W, Henkin TM, Soll D.Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11819-26.PMID: 9342321 ","","Tue Mar 5 13:14:02 2002","1","","","SMU.1821c","968" "SMu1660","1721087","1719336","1752","ATGAAAGAATTATTTATTGGAAATTATGGATTGGAACAAGTTGGGCAAAAAGTAACAGCTAAGGGCTGGGTTGCCAATATCAGAAATCATGGGAAACTGGCTTTCATTGAACTTCGAGATCGTGAAGGTCTGCTGCAAGTGTTTGTAGACAGCGCTGTTGCTGACTTTGATAAGCTTCATGATCTGCATAAGGAAAGTATTTTAGCCGTAACAGGTGAGATTGTGGCACGTGATGAGCGTTTTGTGAATCCTCATATTAAATCCGGACAGGTTGAATTGCGAGCGGAAACAATCGAAATCATTGCCAGCAGTAAACTCTTGCCTTTTGAATTGGACAATCACGCTCATGCTGGTGAAGATATTCGCCAGAAATACCGTTATTTAGATTTGCGCCGTGAGAAGATGACAGCTAATTTGAAGCTGCGTCATCAAGTTACCAAAGCCATTCGTGATTATCTCAATCAGGCTGACTTCATTGATGTCGAGACACCTTATTTAACCAAGTCAACGCCAGAAGGAGCGCGTGACTTCTTGGTACCATCACGTGTCTTTAAAAATCAATTCTATGCTTTGCCACAGAGTCCACAGATGTTGAAGCAACTTTTGATGGGAGCTGGTCTTGAGCGTTATTATCAAATTGTACGTTGTTTCCGTGATGAAGACTTACGTGGTGATCGCCAGCCTGAATTTACTCAGGTCGATTTGGAAATGAGCTTTGTTAGTGAAGAAGATGTTCGCAATCTTGTTGAAGGCATGCTTAAGGCTGTTGTTAAGGCGAGCAAAGGTATTGAATTGACGGAAGCCTTTCCGATAATTTCTTATGCACAAGCCATGCGTCGTTTTGGTTCTGATAAGCCAGATACCCGTTTTGCTATGGAACTTAAGGATTTAACAGAACTTTCCAGAGGAAATACTTCTCTCTTCCTACAAAAAGGTCTTAAAAAAGAAAATGGCGTGGTTATGGGAATCTGTGCTAAGAATGCTGCTAAGGCCTTCACAAATCGTCAAATGGCTACGCTGAAGCAATTGGTCATGGATTTTGGAGTTGCTGGTTTTGCAACTGCAACAATAGAAAAGGGTCAGGTGACAGGATCTTTGAAGTCTACTTTTAAAGATCATAATACAGAATTGTTGGAACTTTTTGAAGCTGAAGATGGCGATATGATTTTCTTTGTAACGGGTTCTCTCAAACGTGTTCAAGAAGCCTTGGGTGGTCTTCGTGTCAGATTGGCTAAGGATTTAGAGTTGATTGATAACGATAAACTGAATTTCCTTTGGGTTGTTGATTGGCCACTTTTGGAATGGAATGAGGATTTGAATCGTTATCAAGCCATGCACCATCCTTTCACTCAAGGAGCCTTTGAAGATGGTAGTGATTGGAAAGAAAATCCAGAGAAAATGATGAGTCGTGCCTACGATATTGTTTTAAATGGTTATGAAATCGGCGGCGGCAGTCTGCGTATTCATAAACGTAGTGCTCAAGAAGCGATGTTTGAATTGCTTGGCATGAAGAAAGAAGATTATGAGCGAGACTTTGGTTTTTTCCTAGAGGCTTTGGAATATGGTTTCCCACCCCATGGAGGTCTAGCTTTGGGACTTGATCGTTTAGTAATGATTCTAGCAGAAGAAGGAAATATCCGCGAAGTGATTGCCTTTCCTAAAAATGGTCAAGGTGCTGATGCCATGCTTGAGAGTCCAAGTTTGGTTGCAGACCAGCAGCTGGCAGAATTGCGCCTAGCTTTGCGTGACTAA","5.50","-12.12","66154","MKELFIGNYGLEQVGQKVTAKGWVANIRNHGKLAFIELRDREGLLQVFVDSAVADFDKLHDLHKESILAVTGEIVARDERFVNPHIKSGQVELRAETIEIIASSKLLPFELDNHAHAGEDIRQKYRYLDLRREKMTANLKLRHQVTKAIRDYLNQADFIDVETPYLTKSTPEGARDFLVPSRVFKNQFYALPQSPQMLKQLLMGAGLERYYQIVRCFRDEDLRGDRQPEFTQVDLEMSFVSEEDVRNLVEGMLKAVVKASKGIELTEAFPIISYAQAMRRFGSDKPDTRFAMELKDLTELSRGNTSLFLQKGLKKENGVVMGICAKNAAKAFTNRQMATLKQLVMDFGVAGFATATIEKGQVTGSLKSTFKDHNTELLELFEAEDGDMIFFVTGSLKRVQEALGGLRVRLAKDLELIDNDKLNFLWVVDWPLLEWNEDLNRYQAMHHPFTQGAFEDGSDWKENPEKMMSRAYDIVLNGYEIGGGSLRIHKRSAQEAMFELLGMKKEDYERDFGFFLEALEYGFPPHGGLALGLDRLVMILAEEGNIREVIAFPKNGQGADAMLESPSLVADQQLAELRLALRD","1719352","For other 'asp' genes see SMu1907 (aspS); SMu1199 (aspB), (aspC) and SMu1667 (aspG).","aspartyl-tRNA synthetase","Cytoplasm","Matches in gapped BLAST to Asp-tRNA synthetases. Residues 14-582 are 51% similar to gi|15924620 from S.aureus. Residues 2-583 are 48% similar to gi|15903965 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2107 (1e-163).","

InterPro
IPR002312
Family

Aspartyl-tRNA synthetase, class IIb
PR01042	$\"[191-203]T$ $\"[208-221]T$ $\"[472-488]T$ $\"[516-530]T$	TRNASYNTHASP

InterPro
IPR004115
Domain

GAD
PF02938	$\"[309-403]T$	GAD

InterPro
IPR004364
Domain

tRNA synthetase, class II (D, K and N)
PF00152	$\"[118-557]T$	tRNA-synt_2

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[18-101]T$	tRNA_anti

InterPro
IPR004524
Family

Aspartyl-tRNA synthetase bacterial/mitochondrial type
PTHR22594:SF5	$\"[89-582]T$	AspS_bac
TIGR00459	$\"[1-582]T$	aspS_bact

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[139-553]T$	AA_TRNA_LIGASE_II

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[1-107]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[111-553]T$	G3DSA:3.30.930.10
PTHR22594	$\"[89-582]T$	PTHR22594
SSF50249	$\"[1-105]T$	Nucleic_acid_OB
SSF55261	$\"[290-417]T$	SSF55261
SSF55681	$\"[96-582]T$	SSF55681

","BeTs to 13 clades of COG0173COG name: Aspartyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0173 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 516-553 are 84% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000848) which is seen in Q9CE80_LACLA.Residues 135-206 are 69% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD330536) which is seen in Q9CE80_LACLA.Residues 14-133 are 39% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD190154) which is seen in SYD_AQUAE.Residues 468-506 are 61% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD383364) which is seen in Q9PCC5_XYLFA.Residues 469-514 are 58% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD006889) which is seen in SYD_THEMA.Residues 515-553 are 61% similar to a (SYNTHETASE LIGASE LYSYL-TRNA) protein domain (PD186099) which is seen in SYK_UREPA.Residues 207-277 are 63% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD000871) which is seen in Q9CE80_LACLA.Residues 35-131 are 45% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD017062) which is seen in Q9CE80_LACLA.Residues 376-464 are 47% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD190340) which is seen in Q9KDG1_BACHD.Residues 281-341 are 36% similar to a (SYNTHETASE LIGASE ATP-BINDING) protein domain (PD291007) which is seen in Q9H9J7_HUMAN.Residues 263-350 are 36% similar to a (LIGASE SYNTHETASE ATP-BINDING ASPRS) protein domain (PD261920) which is seen in SYD_MYCPN.Residues 371-459 are 42% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD206474) which is seen in Q9PCC5_XYLFA.Residues 278-366 are 32% similar to a (SYNTHETASE LIGASE ASPARTYL-TRNA) protein domain (PD037346) which is seen in Q9KDG1_BACHD.Residues 16-131 are 42% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD381092) which is seen in SYD_MYCTU.Residues 5-132 are 38% similar to a (SYNTHETASE LIGASE ASPARTYL-TRNA) protein domain (PD228079) which is seen in SYD_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:38:02 2002","Tue Mar 5 13:16:55 2002","Wed Oct 16 08:38:02 2002","Mon Apr 8 13:09:35 2002","","Tue Mar 5 13:16:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1660 is paralogously related (blast p-value < 1e-3) to SMu1907, another asp-tRNA synthetase, to SMu0701, a lys-tRNA synthetase, and to SMu1198, an asn-tRNA synthetase.","Tue Mar 5 13:27:58 2002","Tue Mar 5 13:16:55 2002","pdb|1EFW|A Chain A, Crystal Structure Of Aspartyl-Trna Syntheta... 495 7e-141pdb|1EQR|A Chain A, Crystal Structure Of Free Aspartyl-Trna Syn... 480 2e-136pdb|1C0A|A Chain A, Crystal Structure Of The E. Coli Aspartyl-T... 480 2e-136","SMU.1822c","","Residues 18 to 101 (E-value = 2e-19) place SMu1660 in the tRNA_anti family which is described as OB-fold nucleic acid binding domain (PF01336)Residues 118 to 557 (E-value = 2.1e-12) place SMu1660 in the tRNA-synt_2 family which is described as tRNA synthetases class II (D, K and N) (PF00152)Residues 309 to 403 (E-value = 2.8e-10) place SMu1660 in the GAD family which is described as GAD domain (PF02938)","Tue Mar 5 13:16:55 2002","","","","","","","1","","","SMU.1822c","" "SMu1661","1721896","1721345","552","ATGAGTAAAGCACTGATTTCAATTGATTATACCTATGATTTTGTTGCCGATGATGGGAAATTAACAGCGGGAAAGCCAGCTCAAGCTATCTCTAAAGCTATTGCTCAAGTCACTCAAAAAGCTTATGATAATGGTGACTATATCTTTTTCACCATTGATGGTCATGATGAAGGTGATGATTTTCATCCTGAAACGAAGCTGTTTCCACCACATAATATCAAGGGTACAAGCGGACGTGATTTGTATGGGGCGCTAGCTGATTTCTATCAGAAGCATGAAAACGATAAACGTGTCTTTTGGATGGACAAGCGCCATTATTCTGCCTTTTCGGGAACGGATTTGGATATTCGCCTGCGAGAGCGTCGTGTTGATACTGTGGTTCTGACGGGTGTTTTGACAGATATTTGTGTTTTGCATACAGCTATTGATGCTTATAATCTTGGTTATCAAATTGAGGTGGTTCAGTCAGCGGTTGCTTCCCTAAGTCAAGAAAATCATCAATTTGCGCTAAACCACTTGCAAAATGTGCTTGGTGCAACTATAATAGAATAG","5.30","-7.13","20498","MSKALISIDYTYDFVADDGKLTAGKPAQAISKAIAQVTQKAYDNGDYIFFTIDGHDEGDDFHPETKLFPPHNIKGTSGRDLYGALADFYQKHENDKRVFWMDKRHYSAFSGTDLDIRLRERRVDTVVLTGVLTDICVLHTAIDAYNLGYQIEVVQSAVASLSQENHQFALNHLQNVLGATIIE","1721361","For other 'pnc' genes see SMu0421 (pncB)."," pyrazinamidase/nicotinamidase","Cytoplasm","Matches in gapped BLAST to isochorismatase and pyrazinamidase/nicotinamidase sequences. Residues 1-183 are 70% similar to gi15901425 from S.pneumoniae. Residues 3-182 are 63% similar to gi15675617 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1674 (6e-74).","

InterPro
IPR000868
Family

Isochorismatase hydrolase
G3DSA:3.40.50.850	$\"[4-178]T$	Isochorismatase_hydro
PF00857	$\"[2-183]T$	Isochorismatase
SSF52499	$\"[1-182]T$	Iscrsm_hydrolase

noIPR
unintegrated

unintegrated
PTHR11080	$\"[64-182]T$	PTHR11080
PTHR11080:SF4	$\"[64-182]T$	PTHR11080:SF4

","BeTs to 9 clades of COG1335COG name: Amidases related to nicotinamidaseFunctional Class: RThe phylogenetic pattern of COG1335 is A--kyqv-EBr-----ol---Number of proteins in this genome belonging to this COG is 2","***** IPB000868 (Isochorismatase hydrolase family) with a combined E-value of 4.8e-31. IPB000868A 5-14 IPB000868B 53-75 IPB000868C 108-162","Residues 102-170 are 52% similar to a (COMPLETE PROTEOME HYDROLASE) protein domain (PD002453) which is seen in O32091_BACSU.Residues 1-101 are 60% similar to a (PROTEOME COMPLETE YUEJ) protein domain (PD098097) which is seen in O32091_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Aug 18 14:54:44 2006","Wed Mar 6 08:34:38 2002","Fri Aug 18 14:54:44 2006","Wed Apr 10 16:17:48 2002","Wed Mar 6 08:34:38 2002","Wed Mar 6 08:34:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1661 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 08:40:23 2002","","No significant hits to the NCBI PDB database.","SMU.1823c","","Residues 2 to 183 (E-value = 4.2e-16) place SMu1661 in the Isochorismatase family which is described as Isochorismatase family (PF00857)","Wed Mar 6 08:34:38 2002","","","","Scorpio A, Zhang Y.Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.Nat Med. 1996 Jun;2(6):662-7.PMID: 8640557 ","","Wed Mar 6 08:40:23 2002","1","","","SMU.1823c","718" "SMu1662","1722683","1721898","786","ATGGCTAATTTATTATCGAAAACGCGACGTATTACATCCATTTTACAACGCTCGGTTGAGAGCCTTCAAAGTGATTTGCCTTATAATACGATTGCAGATCAATTGGCTGAAATTATTGATTGTAATGCTTGTATTATTGATGGTAGTGGTATTATTCTCGGCTATGCTATGAAGTATAAAACCAATACAGATCGTGTTGAAGAATTTTTCCAAGCTAAAAAATTACCTGATGATTATGTAAAATCGGCCAGCCGTATTTATGATACAGAAGCCAATCTGTCGGTTGAAAATGATTTGACCATTTTTCCAATTGAATCAAAAGATATCTATCCTGATGGCTTGACGACTATTGCTCCCATCTATGGCGGCGGTATGCGTCTTGGTTCTCTTATTATCTGGCGTAATGATAAAGAATTCAATGATGACGATTTGATTCTAATTGAGATTTCTTCTACTGTTGTTGGAATTCAATTATTGAACTTGCAGACAGAAAATCTTGAAGAAACAATTCGTAAGCAGACTGCTATTAATATGGCGATTAATACCTTGTCTTATTCAGAAATGAAGGCTGTCGCAGCTATTCTCAATGAATTAGATGGCAATGAAGGTCGCTTGACCGCATCGGTTATTGCTGATCGTATCGGTATTACACGTAGCGTGATTGTTAATGCTCTTAGAAAGTTAGAAAGTGCCGGTATTATTGAAAGTCGTTCCTTAGGTATGAAAGGTACTTATCTCAAAGTTATTAATGAAGGTATTTTTGATAAATTAAAGGACTATAGTTAA","4.60","-9.08","28956","MANLLSKTRRITSILQRSVESLQSDLPYNTIADQLAEIIDCNACIIDGSGIILGYAMKYKTNTDRVEEFFQAKKLPDDYVKSASRIYDTEANLSVENDLTIFPIESKDIYPDGLTTIAPIYGGGMRLGSLIIWRNDKEFNDDDLILIEISSTVVGIQLLNLQTENLEETIRKQTAINMAINTLSYSEMKAVAAILNELDGNEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVINEGIFDKLKDYS","1721914","","GTP-sensing transcriptional repressor","Cytoplasm","Matches in gapped BLAST to transcriptional regulators. Residues 1-260 are 81% similar to gi15675618 from S.pyogenes. Residues 1-258 are 69% similar to gi15901426 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1675 (1e-115).","

InterPro
IPR000485
Family

Bacterial regulatory proteins, AsnC/Lrp
PR00033	$\"[204-215]T$ $\"[215-234]T$	HTHASNC

InterPro
IPR010312
Domain

GTP-sensing transcriptional pleiotropic repressor CodY, N-terminal
PF06018	$\"[3-188]T$	CodY

InterPro
IPR013198
Domain

GTP-sensing helix-turn-helix, CodY, C-terminal
PF08222	$\"[201-261]T$	HTH_CodY

InterPro
IPR014154
Family

GTP-sensing transcriptional pleiotropic repressor CodY
TIGR02787	$\"[4-257]T$	codY_Gpos

noIPR
unintegrated

unintegrated
SSF46785	$\"[183-246]T$	SSF46785

","No hits to the COGs database.","***** IPB001845 (Bacterial regulatory proteins, ArsR family) with a combined E-value of 1.3e-06. IPB001845B 203-247","Residues 1-199 are 55% similar to a (TRANSCRIPTIONAL COMPLETE PROTEOME) protein domain (PD404820) which is seen in Q9CJ45_LACLA.Residues 200-250 are 86% similar to a (TRANSCRIPTIONAL COMPLETE PROTEOME) protein domain (PD122163) which is seen in CODY_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 17 08:06:37 2002","Mon Sep 18 16:22:59 2006","Mon Sep 18 16:22:59 2006","Wed Mar 6 08:53:43 2002","Wed Mar 6 08:53:43 2002","Wed Mar 6 08:53:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1662 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 17 08:06:37 2002","","No significant hits to the NCBI PDB database.","SMU.1824c","","Residues 3 to 261 (E-value = 6.3e-191) place SMu1662 in the CodY family which is described as GTP-sensing transcriptional pleiotropic repressor CodY (PF06018)","Wed Mar 6 08:53:43 2002","24380188","","","","","","1","","","SMU.1824c","457" "SMu1663","1724009","1722792","1218","ATGATGAAAGAATTTAATAAGTCTGCTAAACTTGAACATGTGGCCTATGATATTCGCGGTCCAGTATTAGAAGAAGCCGATCGTATGATTGCTAATGGGGAGAAAATCTTACGTCTTAATACAGGAAATCCTGCCGCTTTTGGATTAACAGCACCTGATGAGGTTATTCGGGATTTAATTATGAATGCGCGTGAGAGCGAAGGTTATTCAGATTCGAAGGGAATCTTTTCAGCTCGTAAAGCTATTATGCAATATTGTCAGCTTAAAAATATTCCTGATGTTGATGTTGATGACATCTATATTGGCAATGGTGTATCGGAAATGATTACTATGTCTATGCAAGGACTTTTAGATGACGGTGACGAAGTTTTAGTCCCCATGCCTGATTATCCACTGTGGACGGCTGCTGTTAGTCTGGCAGGAGGTCAGGCTGTTCATTATGTCTGTGATGAAAGTTCCAATTGGTATCCAGATATTGATAATATTAAGTCTAAAATCACTTCAAATACGAAAGCTCTTGTGGTTATCAATCCTAATAACCCTACAGGGGCTCTTTATCCCAAAGATGTATTAGAAGATATCGTTGAAGTTGCTCGTCAGAATGATTTAATTATTTTTGCTGATGAGATTTATGATCGTCTGGTCATGGATGGTGGGGAACATGTGGCTATTGCTAGTCTTGCACCGGATCTTTTTTGTGTTTCTATGAATGGTTTGTCAAAATCCCATCGTATTGCAGGTTTCCGTGTAGGTTGGATGGTTTTATCTGGGCCTAAAAAACATGTCAAAGATTATATTGAAGGCCTTAACATGCTTTCAAATATGCGCCTTTGTTCTAATGTTCTGGCTCAACAAGTTATTCAAACATCTTTGGGCGGCGTTCAGTCTATTGATGAACTTCTTTTGCCGGGTGGCCGTATTTATGAACAGCGTAATTTTATTTATAAAGCTATGAATGAAATCCCTGGAATCACAGCGGTAAAACCTCAGGCGGGACTTTATATTTTCCCAAAAATTGACCGTAATATGTATCGGATTGATGATGATGAGCAATTTGTTCTGAATTTTCTCAAACAGGAAAAAATCCTTCTTGTTCATGGACGCGGCTTTAACTGGATGGAACCAGATCATTTCCGTATTGTTTATTTACCGCGCGTTGAAGAGCTCTCTAAGATTCAAGAAAAGATGACACGCTTCCTAGGGCAATATCGAAAATAA","5.10","-10.47","45591","MMKEFNKSAKLEHVAYDIRGPVLEEADRMIANGEKILRLNTGNPAAFGLTAPDEVIRDLIMNARESEGYSDSKGIFSARKAIMQYCQLKNIPDVDVDDIYIGNGVSEMITMSMQGLLDDGDEVLVPMPDYPLWTAAVSLAGGQAVHYVCDESSNWYPDIDNIKSKITSNTKALVVINPNNPTGALYPKDVLEDIVEVARQNDLIIFADEIYDRLVMDGGEHVAIASLAPDLFCVSMNGLSKSHRIAGFRVGWMVLSGPKKHVKDYIEGLNMLSNMRLCSNVLAQQVIQTSLGGVQSIDELLLPGGRIYEQRNFIYKAMNEIPGITAVKPQAGLYIFPKIDRNMYRIDDDEQFVLNFLKQEKILLVHGRGFNWMEPDHFRIVYLPRVEELSKIQEKMTRFLGQYRK","1722808","","aminotransferase","Cytoplasm","Matches in gapped BLAST to aminotransferases. Residues 2-405 are 85% similar to gi|15903850 from S.pneumoniae and 81% similar to gi|15675619 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1676 (0.0).","

InterPro
IPR001176
Family

1-aminocyclopropane-1-carboxylate synthase
PR00753	$\"[120-141]T$ $\"[167-191]T$ $\"[203-226]T$	ACCSYNTHASE

InterPro
IPR004839
Domain

Aminotransferase, class I and II
PF00155	$\"[34-380]T$	Aminotran_1_2

InterPro
IPR015421
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 1
G3DSA:3.40.640.10	$\"[64-294]T$	PyrdxlP-dep_Trfase_major_sub1

InterPro
IPR015422
Domain

Pyridoxal phosphate-dependent transferase, major region, subdomain 2
G3DSA:3.90.1150.10	$\"[307-404]T$	PyrdxlP-dep_Trfase_major_sub2

InterPro
IPR015424
Domain

Pyridoxal phosphate-dependent transferase, major region
SSF53383	$\"[5-394]T$	PyrdxlP-dep_Trfase_major

noIPR
unintegrated

unintegrated
PTHR11751	$\"[54-405]T$	PTHR11751
PTHR11751:SF30	$\"[54-405]T$	PTHR11751:SF30

InterPro
IPR003784
Family

BioY protein
PF02632	$\"[25-174]T$	BioY

","BeTs to 8 clades of COG1268COG name: Uncharacterized ACR, BioY familyFunctional Class: RThe phylogenetic pattern of COG1268 is a-tk--vc-B-------li-xNumber of proteins in this genome belonging to this COG is 1","***** IPB003784 (BioY) with a combined E-value of 2.3e-24. IPB003784 45-95","Residues 43-169 are 40% similar to a (COMPLETE PROTEOME BIOTIN BIOY) protein domain (PD009527) which is seen in Q9CEQ5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:24:02 2002","Wed Mar 6 09:08:25 2002","Wed Oct 16 08:24:02 2002","Wed Oct 16 08:24:02 2002","Wed Mar 6 09:08:25 2002","Wed Mar 6 09:08:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1664 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 08:24:02 2002","","No significant hits to the NCBI PDB database.","SMU.1827","","Residues 25 to 174 (E-value = 1.2e-30) place SMu1664 in the BioY family which is described as BioY family (PF02632)","Wed Mar 6 09:08:25 2002","24380190","","","Ollagnier-De Choudens S, Sanakis Y, Hewitson KS, Roach P, Baldwin JE, Munck E, Fontecave M.Iron-sulfur center of biotin synthase and lipoate synthase.Biochemistry. 2000 Apr 11;39(14):4165-73.PMID: 10747808Gibson KJ, Pelletier DA, Turner IM Sr.Transfer of sulfur to biotin from biotin synthase (BioB protein).Biochem Biophys Res Commun. 1999 Jan 27;254(3):632-5.PMID: 9920791 ","","Wed Mar 6 09:08:25 2002","1","","","SMU.1827","1006" "SMu1665","1724817","1725266","450","ATGTCCAGCTATAAAAATATCCTAGTTGCCATTGATGGCTCCTACGAATCAGAGCTTGCCTTTGAAAAGGGTGTCAGTGTCGCACTTAGAAATGATGCTAATTTGCTTTTAACACATGTCGTTGATACACGAGCTCTTCAAAGTGTTGCAACGTTTGATGCTTATATTTATGAAAAGTTGGAACAAGAAGCTCACAGTGTTCTGGATGATTATGAAAACCAAGCCCGTGAAAGAGGCCTAGAAAAGGTTAGGCAGATTATCGAATTTGGAAACCCAAAACCTCTGTTAGCTACTGAAATTCCTGAGCGAGAACATGTTGACCTCATTATGTTGGGAGCAACAGGTCTCAACGCTTTTGAACGACTTTTAATCGGTTCTTCATCCGAATATATCCTTCGCCACGCCAAGGTTGATTTATTGGTCGTTCGTGATCCCGAAAAAACATTATAA","4.70","-8.03","16756","MSSYKNILVAIDGSYESELAFEKGVSVALRNDANLLLTHVVDTRALQSVATFDAYIYEKLEQEAHSVLDDYENQARERGLEKVRQIIEFGNPKPLLATEIPEREHVDLIMLGATGLNAFERLLIGSSSEYILRHAKVDLLVVRDPEKTL","1725276","","universal stress protein family","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 4-149 are 67% similar to gi15903852 from S.pneumoniae. Residues 1-144 are 50% similar to gi16800683 from L.innocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1677 (3e-62).","

InterPro
IPR006015
Family

Universal stress protein (Usp)
PR01438	$\"[4-22]T$ $\"[103-115]T$ $\"[121-143]T$	UNVRSLSTRESS

InterPro
IPR006016
Domain

UspA
PF00582	$\"[3-143]T$	Usp

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[4-149]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
SSF52402	$\"[1-145]T$	SSF52402

","BeTs to 10 clades of COG0589COG name: Universal stress protein UspA and related nucleotide-binding proteinsFunctional Class: TThe phylogenetic pattern of COG0589 is AMTK-Q-CEBRH--------xNumber of proteins in this genome belonging to this COG is 1","***** PR01438 (Universal stress protein signature) with a combined E-value of 3e-18. PR01438A 4-22 PR01438B 103-115 PR01438C 121-143","Residues 90-143 are 50% similar to a (COMPLETE PROTEOME CHROMOSOME NODULIN) protein domain (PD001144) which is seen in Q9CEK4_LACLA.Residues 4-80 are 41% similar to a (PROTEOME COMPLETE UNIVERSAL STRESS) protein domain (PD030450) which is seen in Q9CEK4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:43:20 2002","Mon Jul 17 15:26:48 2006","Mon Jul 17 15:26:48 2006","Tue Oct 8 15:43:20 2002","Wed Mar 6 09:12:22 2002","Wed Mar 6 09:12:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1665 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:43:20 2002","","No significant hits to the NCBI PDB database.","SMU.1828","","Residues 3 to 143 (E-value = 3.9e-20) place SMu1665 in the Usp family which is described as Universal stress protein family (PF00582)","Wed Mar 6 09:12:22 2002","24380191","","","","","","1","","","SMU.1828","850" "SMu1666","1726944","1725544","1401","ATGAAAGGTAATATTGTGGCAATCAAGGCTGTCTTTTTTGATATTGATGGGACGCTTTTAAATGATCGAAAACAGGTTCAGAAATCGACACAAGATGCAATTGCAAATATGAAAAAACAAGGCATCTTCGTTGGTGTAGCAACTGGTCGGGGTCCGGCTTTTGTTGCGCCTTTTATGGAAAATTTAGGGCTTGATTTTGCTATCACCTATAATGGTCAATATATTTTCACGCGCGATCGTATTTTATACCAAAATCAGTTACCCAAATCAACAGTTTATCGTCTTATTAAATACGCCAGTGAACAAAGGCGAGAAATTTCTCTGGGAACGAGTTCTGGTCTTGTTGGTTCTAATATCATTAACATGGGAACCAGTCGTTTTGGTCAATGGATCAGTCGTATGGTTCCCAAAAGGTGGACTAAAACGATTACTCGTAGTTTTAAACATGTAGTTCGTCGTGTTAAACCACAGAGCTTAAATAGTTTGATGACCATTATGCGCCAGCCTATCTTTCAAATTGTTTTGGTGGCAACTAAGGAACAAAGTGACATTATTGCTAAAAAATTCCCCCATTTGACCATTACTCGCAGTAGCCTGTACTCTGCTGATTTAATTTCTAAAGGCATGTCCAAAATAAAGGGTGTTTTATGTGTTGCCAGAGAATTTGATATTGAAATAGAAGAAGTCATGGCTTTTGGTGATTCTGATAACGATCTTGAAATGTTATCAGGAGTTGGGATAAGTGTTGCTATGGGCAATGCTACTGAACAAGTCAAAACGATTGCGGACTATACAACTGCTAGCAATAATAATGATGGTATTTCTCAGGCTCTAGCACATTTTGGTGTTATCCATCAAAAAACAGATAGAGTCTTTTCAAGTAGTGATGACAATTTTAATAAAGTCAAAGATTTTCATCAACTAATGGATGGCGAAACCTGTGAAATACCTAGAATTTACGACATTGTTGAAGGTGGGCACCGTTCAGCTTTTAAAGCTGAAGAAATTGTTGAATTCTTATATGCTACAAGTAACGGTGATAAGGAAGAATTTGCTCAAGCACTTGCTAGACTTCATAAAGCGGTTGATAAGGCTGCAGAGAAAGTTTTGTCAAAGCCGCATCCAGAAACGCCTTTAGTTGGACAAGTAGATGCTTTGATTGATTTATTGTATCTCACTTATGGTTCCTTTGTATTAATGGGAGTAGACCCTAAACCCTTTTTTGATACAGTACATGAAGCTAATATTGGAAAGATCTTTCCAGATGGTAAGGCCCATTTTGATCCAGAAACACATAAAATTTTAAAGCCTGATGACTGGGAAGAGCGCTTTGCACCTGAACCAGCCATCAAAAGAGAATTGGATCGTCAAATCCAGAAATCCTTACAGCATCGTAAATGA","9.00","5.83","52316","MKGNIVAIKAVFFDIDGTLLNDRKQVQKSTQDAIANMKKQGIFVGVATGRGPAFVAPFMENLGLDFAITYNGQYIFTRDRILYQNQLPKSTVYRLIKYASEQRREISLGTSSGLVGSNIINMGTSRFGQWISRMVPKRWTKTITRSFKHVVRRVKPQSLNSLMTIMRQPIFQIVLVATKEQSDIIAKKFPHLTITRSSLYSADLISKGMSKIKGVLCVAREFDIEIEEVMAFGDSDNDLEMLSGVGISVAMGNATEQVKTIADYTTASNNNDGISQALAHFGVIHQKTDRVFSSSDDNFNKVKDFHQLMDGETCEIPRIYDIVEGGHRSAFKAEEIVEFLYATSNGDKEEFAQALARLHKAVDKAAEKVLSKPHPETPLVGQVDALIDLLYLTYGSFVLMGVDPKPFFDTVHEANIGKIFPDGKAHFDPETHKILKPDDWEERFAPEPAIKRELDRQIQKSLQHRK","1725560","","conserved hypothetical protein","Cytoplasm, Membrane","Matches in gapped BLAST to conserved hypothetical proteins. Residues 6-463 are 67% similar to gi|15675621 from S.pyogenes. Residues 8-466 are 54% similar to >gi|15901820 from S.pneumoniae, a predicted Cof family protein.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1678 (0.0).","

InterPro
IPR000150
Family

Cof protein
TIGR00099	$\"[10-278]T$	Cof-subfamily
PS01228	$\"[10-21]?$	COF_1
PS01229	$\"[232-254]T$	COF_2

InterPro
IPR006379
Family

HAD-superfamily hydrolase, subfamily IIB
TIGR01484	$\"[10-251]T$	HAD-SF-IIB

InterPro
IPR013200
Domain

HAD superfamily hydrolase-like, type 3
PF08282	$\"[11-278]T$	Hydrolase_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1000	$\"[4-281]T$	G3DSA:3.40.50.1000
SSF56784	$\"[1-287]T$	SSF56784

","BeTs to 12 clades of COG0561COG name: Predicted hydrolases of the HAD superfamilyFunctional Class: RThe phylogenetic pattern of COG0561 is a-tky-vCEBrH--GPOlin-Number of proteins in this genome belonging to this COG is 11","***** IPB000150 (Cof protein) with a combined E-value of 2.4e-30. IPB000150A 7-21 IPB000150B 41-50 IPB000150C 230-262","Residues 8-197 are 24% similar to a (PROTEOME COMPLETE YCEE Y) protein domain (PD415810) which is seen in Q9CIW2_LACLA.Residues 382-457 are 71% similar to a (PROTEOME COMPLETE YHED) protein domain (PD351823) which is seen in Q9CHJ4_LACLA.Residues 264-381 are 54% similar to a (PROTEOME COMPLETE YHED) protein domain (PD396035) which is seen in Q9CHJ4_LACLA.Residues 19-107 are 49% similar to a (PROTEOME COMPLETE YJBC YRAE) protein domain (PD095670) which is seen in Q9CHJ4_LACLA.Residues 108-215 are 37% similar to a (PROTEOME COMPLETE YHED) protein domain (PD394915) which is seen in Q9CHJ4_LACLA.Residues 209-264 are 51% similar to a (PROTEOME COMPLETE HYDROLASE ATPASE) protein domain (PD001342) which is seen in Q9CKQ1_PASMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 09:16:43 2002","Wed Mar 6 09:15:13 2002","Wed Mar 6 09:16:43 2002","Tue Oct 8 15:42:45 2002","Wed Mar 6 09:15:13 2002","Wed Mar 6 09:15:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1666 is paralogously related (blast p-value < 1e-3) to SMu0461, SMu0388, SMu0655, SMu0442, SMu0675, SMu1012, SMu0674, and SMu0367, all conserved hypotheticals.","Wed Mar 6 09:16:43 2002","","No significant hits to the NCBI PDB database.","SMU.1830c","","Residues 8 to 255 (E-value = 4.7e-08) place SMu1666 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Wed Mar 6 09:15:13 2002","24380192","","","","","","1","","","SMU.1830c","171" "SMu1667","1727002","1727961","960","ATGAAAAGAATCCTTGTTTTACATACTGGAGGAACCATTTCCATGCATGCTGATAAGGCTGGTAGGGTTGTTCCAGACAGTGATAACCCTATGAACCATGCCAGTGTCAAACTTGATGATATTCAGATTAATGCTATTGATTTTTTAAACATTCCCAGTCCGCAAATAACAGTGGAGCATATGCTTTTATTGACTCAAAAAATTAGAGAAACAGCTGGCTTATACGATGGCGTGGTTATTACACATGGAACAGACACTTTAGAAGAGACTGCTTACTTCCTAGACACTATGATTTTGCCACAAATTCCCATTGTTTTGACTGGAGCTATGCGTTCTTCCAATGAGTTAGGGAGTGATGGTGTTTACAATTACTTATCTGCCCTTCGTGTTGCCAGCCATGACAATGCTGCTGACAAGGGAGTCCTTGTCGTCATGAATGATGAAATTCATGCTGCCAAATACGTTACCAAAACACATACTACTAATGTTTCTACTTTTCAAACACCTACACATGGACCGCTTGGTATCATTATGAAACATGATATTCTCTTTTTCAAAACAGCTGAACCGCGGGTTCGTTTTCGCCTAGAATCTTTAACAGGAACTGTTCCCATTATCAAGGCATACGCTGGTATGGGTGATTGGCTTTTAAATATTTTAGATAAAAGCAGTATTGATGGTTTGGTTGTTGAAGCTCTAGGTGCTGGTAACCTTCCACCCGAGGCTGCTCAAAGCATTACCAAGCTCATTCAAGAAGGAATTCCTGTCGCTCTCGTCTCTCGATGTTTTAACGGGATTGCAGAGCCTGTCTACGCTTACCAAGGTGGCGGTGTCAAACTGCAAGAAGCAGGTGTCATGTTTGTTAGGGAACTCAATGCCCCTAAGGCCAGACTCAAACTTCTCATTGCTCTCAACGCTGGCCTCAAGGGGCAAGAATTAAAAGAATACATAGAAGGTTAA","6.40","-3.63","34563","MKRILVLHTGGTISMHADKAGRVVPDSDNPMNHASVKLDDIQINAIDFLNIPSPQITVEHMLLLTQKIRETAGLYDGVVITHGTDTLEETAYFLDTMILPQIPIVLTGAMRSSNELGSDGVYNYLSALRVASHDNAADKGVLVVMNDEIHAAKYVTKTHTTNVSTFQTPTHGPLGIIMKHDILFFKTAEPRVRFRLESLTGTVPIIKAYAGMGDWLLNILDKSSIDGLVVEALGAGNLPPEAAQSITKLIQEGIPVALVSRCFNGIAEPVYAYQGGGVKLQEAGVMFVRELNAPKARLKLLIALNAGLKGQELKEYIEG","1727971","For other 'asp' genes see SMu1907 (aspS); SMu1199 (aspB), (aspC) and SMu1660 (aspS).","L-asparaginase","Cytoplasm","Matches in gapped BLAST to L-asparaginases. Residues 2-319 are 76% similar to gi|15901821 from S.pneumoniae. Residues 1-319 are 74% similar to gi|15675622 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1679 (1e-138).","

InterPro
IPR000890
Family

Acetate and butyrate kinase
PS01076	$\"[4-21]?$	ACETATE_KINASE_2

InterPro
IPR006034
Family

Asparaginase/glutaminase
PD003221	$\"[6-229]T$	Asp/Glutamnse
PR00139	$\"[4-15]T$ $\"[76-94]T$ $\"[249-267]T$	ASNGLNASE
PIRSF001220	$\"[1-319]T$	L-ASNase_gatD
PTHR11707	$\"[48-318]T$	Asp/Glutamnse
PF00710	$\"[3-314]T$	Asparaginase
PS00144	$\"[6-14]?$	ASN_GLN_ASE_1
PS00917	$\"[77-87]T$	ASN_GLN_ASE_2
SSF53774	$\"[1-319]T$	Asp/Glutamnse

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1170	$\"[1-207]T$	G3DSA:3.40.50.1170
PIRSF500176	$\"[1-319]T$	L_ASNase
PTHR11707:SF4	$\"[48-318]T$	PTHR11707:SF4

","BeTs to 9 clades of COG0252COG name: L-asparaginaseFunctional Class: EThe phylogenetic pattern of COG0252 is amtKY---EBrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000267 (Asparaginase/glutaminase family) with a combined E-value of 1.1e-65. IPB000267A 1-17 IPB000267B 30-68 IPB000267C 76-120 IPB000267D 127-168 IPB000267E 291-317","Residues 203-304 are 30% similar to a (L-ASPARAGINASE PROTEOME COMPLETE HYDROLASE) protein domain (PD344636) which is seen in O59132_PYRHO.Residues 1-162 are 61% similar to a (L-ASPARAGINASE HYDROLASE COMPLETE PROTEOME L-ASPARAGINE) protein domain (PD003221) which is seen in Q9CHJ5_LACLA.Residues 172-307 are 55% similar to a (L-ASPARAGINASE PROTEOME COMPLETE) protein domain (PD304321) which is seen in Q9CHJ5_LACLA.Residues 203-315 are 28% similar to a (L-ASPARAGINASE HYDROLASE AMIDOHYDROLASE L-ASPARAGINE) protein domain (PD244538) which is seen in Q9V0T9_PYRAB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:22:01 2002","Wed Mar 6 09:18:00 2002","Wed Oct 16 08:22:01 2002","Mon Apr 8 13:10:09 2002","Wed Mar 6 09:18:00 2002","Wed Mar 6 09:18:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1667 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 09:23:26 2002","Wed Mar 6 09:18:00 2002","pdb|3ECA|A Chain A, Asparaginase Type Ii (E.C.3.5.1.1) (Eca) >g... 145 7e-036pdb|1HFJ|A Chain A, Asparaginase From Erwinia Chrysanthemi, Hex... 143 3e-035pdb|4ECA|A Chain A, Asparaginase From E. Coli, Mutant T89v With... 141 1e-034","SMU.1831","","Residues 8 to 315 (E-value = 1.8e-64) place SMu1667 in the Asparaginase family which is described as Asparaginase (PF00710)","Wed Mar 6 09:18:00 2002","24380193","","","Wang Y, Qian S, Meng G, Zhang S.Cloning and expression of L-asparaginase gene in Escherichia coli.Appl Biochem Biotechnol. 2001 Aug;95(2):93-101.PMID: 11694066","","Wed Mar 6 09:23:26 2002","1","","","SMU.1831","458" "SMu1668","1727988","1728152","165","ATGAAGCTTAATATTACTGCTACAGACAAGTCTAAAAATCAGCACTTTAACTATTCTCTAGAATTATCCAGCAAGCAGGTTCAAAATACGACCTTAATTATTTGCGGCACAGTCTTGTTAGGTATTCTTTTCAAATCCTATTTAAAGAGCCAAAAATCAGTCTAA","10.50","5.17","6059","MKLNITATDKSKNQHFNYSLELSSKQVQNTTLIICGTVLLGILFKSYLKSQKSV","1728162","","hypothetical protein","Extracellular","No significant hits in gapped BLAST.SMu1668 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[26-44]?$	transmembrane_regions

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[491-567]T$	Helicase_C
SM00490	$\"[486-567]T$	HELICc
PS51194	$\"[445-605]T$	HELICASE_CTER

InterPro
IPR004609
Family

ATP-dependent DNA helicase RecG
TIGR00643	$\"[24-642]T$	recG

InterPro
IPR011545
Domain

DEAD/DEAH box helicase, N-terminal
PF00270	$\"[254-416]T$	DEAD

InterPro
IPR014001
Domain

DEAD-like helicases, N-terminal
SM00487	$\"[249-437]T$	DEXDc

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[267-426]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[443-579]T$	G3DSA:3.40.50.300
PTHR10967	$\"[253-579]T$	PTHR10967
SSF50249	$\"[1-172]T$	Nucleic_acid_OB

","BeTs to 10 clades of COG1200COG name: RecG-like helicasesFunctional Class: L,KThe phylogenetic pattern of COG1200 is -----qvcebrhuj--ol--xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 223-565 are 21% similar to a (PROTEOME COMPETENCE COMPLETE ATP-BINDING) protein domain (PD132737) which is seen in CMF1_BACSU.Residues 12-275 are 64% similar to a (DNA HELICASE ATP-BINDING ATP-DEPENDENT) protein domain (PD233697) which is seen in RECG_STRPN.Residues 479-530 are 61% similar to a (HELICASE ATP-BINDING RNA RNA-BINDING ATP-DEPENDENT) protein domain (PD000033) which is seen in Q9CDH6_LACLA.Residues 276-379 are 62% similar to a (HELICASE DNA ATP-BINDING COMPLETE PROTEOME DNA-BINDING) protein domain (PD003500) which is seen in RECG_STRPN.Residues 352-409 are 35% similar to a (ATP-BINDING RECOMBINASE HELICASE DNA) protein domain (PD392202) which is seen in Q9ZVG0_ARATH.Residues 531-640 are 89% similar to a (HELICASE DNA ATP-BINDING PROTEOME) protein domain (PD008437) which is seen in RECG_STRPN.Residues 410-478 are 73% similar to a (HELICASE DNA ATP-BINDING ATP-DEPENDENT) protein domain (PD035483) which is seen in RECG_STRPN.Residues 380-409 are 86% similar to a (HELICASE DNA ATP-BINDING COUPLING) protein domain (PD398886) which is seen in RECG_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 16 08:21:55 2006","Wed Aug 16 08:21:55 2006","Wed Aug 16 08:21:55 2006","Wed Apr 3 09:15:54 2002","","Wed Mar 6 09:25:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1669 is paralogously related (blast p-value < 1e-3) to SMu0006, a predicted transcription-repair coupling factor, to SMu0734, an excinuclease ABC (subunit B), to SMu0451, a late competence protein, to SMu0557, an ATP-dependent RNA helicase, and to SMu0434, a primosomal replication factor Y.","Wed Mar 6 09:39:39 2002","","No significant hits to the NCBI PDB database.","SMU.1833c","","Residues 243 to 437 (E-value = 6.8e-26) place SMu1669 in the DEAD family which is described as DEAD/DEAH box helicase (PF00270)Residues 491 to 567 (E-value = 4.2e-23) place SMu1669 in the Helicase_C family which is described as Helicase conserved C-terminal domain (PF00271)","Wed Aug 16 08:21:55 2006","","","","Gregg AV, McGlynn P, Jaktaji RP, Lloyd RG.Direct Rescue of Stalled DNA Replication Forks via the Combined Action of PriA and RecG Helicase Activities.Mol Cell. 2002 Feb;9(2):241-51.PMID: 11864599Dillingham MS, Kowalczykowski SC.A step backward in advancing DNA replication: rescue of stalled replication forks by RecG.Mol Cell. 2001 Oct;8(4):734-6.PMID: 11684009 McGlynn P, Lloyd RG, Marians KJ.Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled.Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8235-40.PMID: 11459958 ","","Wed Mar 6 09:33:56 2002","1","","","SMU.1833c","172" "SMu1670","1731598","1730483","1116","ATGATTGCTAGTTACCATCGTCCGACGACAGCTTTAGTTCATTTAGATCGTATCAAATTTAATATCGAACAAGTTCAACACCATATTCCAAAATCAGCCAAAACTTTTGCTGTGGTTAAAGCCAATGCCTATGGACATGGTGCTGTTCAGGTGGCTCAAGCCATTCAAAAGCAAGTTGACGGTTTTTGTGTTTCTAATTTAGATGAGGCCTTGGAATTGCGTCAGGCTGGTCTAAATGATTTTATTTTAATTTTGGGTGTCCTTCTTCCTGAGGAAGTTGCCTTGGCTAAAAAAGAAAATATTACTATTACAGTTGCTGACTTAGATTGGTTTGATAAAGTACAGACAGAAAACATTGATTTAGCTGGTCTTTCAGTACATGTAAAAGTCGATTCTGGTATGGGAAGAATTGGAGTTCGCAGTACTGCAGAAGCGAATCAGCTTATTGCAGGTTTGCAGAAGGCGGGAGCGACTGTTAATGGTATCTTTACCCATTTTGCAACAGCAGATGAAGCTTCTACTGTTAAATTCAGTCAACAGTTAGAGATGTTTACCACCCTTATCAGTCAATTGGATTACAAACCTCAAACAGTACATGCTTCTAACTCTGCTACAAGTATTTGGCATAGTGATACAGTAATGAATGCTGTTCGCCTGGGAATAGTGATGTATGGACTCAATCCTAGTGGCAATGCACTTGAATTACCTTATGAAGTAAAGCCAGCATTAGAGTTGACATCCGCTCTTGTTCAGGTCAAAGAAGTGCAAGCTGGTGATACAGTTGGCTATGGTGCGACTTATACTGCCAGTCAGGCTGAAATTATTGGAACCGTCCCTGTTGGTTACGCTGATGGTTGGACAAGAGATTTGCAAGGTTTTCATGTTTTGGTGAATGGTCACTATTGTGAAATTGTGGGGCGTGTGTCCATGGATCAAATCACTATTCGCTTACCCAAAGCTTATCCTTTAGGGACCAAAGTCACCTTAATTGGGCAGGATGGTCATGAAACGATTTCAGCAACAGATGTCGCTGAAAAACGAGAGACGATTAATTATGAAGTGCTCTGTTTGATCAGTGACCGAGTTCCTCGAAAATATGATAAAAAGTTCAGTTAA","6.20","-5.24","40408","MIASYHRPTTALVHLDRIKFNIEQVQHHIPKSAKTFAVVKANAYGHGAVQVAQAIQKQVDGFCVSNLDEALELRQAGLNDFILILGVLLPEEVALAKKENITITVADLDWFDKVQTENIDLAGLSVHVKVDSGMGRIGVRSTAEANQLIAGLQKAGATVNGIFTHFATADEASTVKFSQQLEMFTTLISQLDYKPQTVHASNSATSIWHSDTVMNAVRLGIVMYGLNPSGNALELPYEVKPALELTSALVQVKEVQAGDTVGYGATYTASQAEIIGTVPVGYADGWTRDLQGFHVLVNGHYCEIVGRVSMDQITIRLPKAYPLGTKVTLIGQDGHETISATDVAEKRETINYEVLCLISDRVPRKYDKKFS","1730499","","alanine racemase","Cytoplasm","Matches in gapped BLAST to alanine racemase sequences. Residues 1-366 are 64% similar to gi|15675637 in S.pyogenes and 60% similar to gi|15903583 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1684 (1e-139).","

InterPro
IPR000821
Domain

Alanine racemase region
PR00992	$\"[32-48]T$ $\"[67-85]T$ $\"[127-139]T$ $\"[161-172]T$ $\"[201-228]T$ $\"[258-273]T$ $\"[275-290]T$ $\"[295-312]T$ $\"[349-362]T$	ALARACEMASE
TIGR00492	$\"[7-368]T$	alr
PS00395	$\"[37-47]T$	ALANINE_RACEMASE

InterPro
IPR001608
Domain

Alanine racemase, N-terminal
PF01168	$\"[8-229]T$	Ala_racemase_N

InterPro
IPR009006
Domain

Alanine racemase/group IV decarboxylase, C-terminal
SSF50621	$\"[233-366]T$	Racem_decarbox_C

InterPro
IPR011079
Domain

Alanine racemase, C-terminal
PF00842	$\"[242-367]T$	Ala_racemase_C

InterPro
IPR012155
Family

Alanine racemase
PIRSF001401	$\"[11-368]T$	Ala_racemase

noIPR
unintegrated

unintegrated
G3DSA:2.40.37.10	$\"[229-366]T$	G3DSA:2.40.37.10
G3DSA:3.20.20.10	$\"[2-223]T$	G3DSA:3.20.20.10
SSF51419	$\"[13-243]T$	SSF51419

","BeTs to 9 clades of COG0787COG name: Alanine racemaseFunctional Class: MThe phylogenetic pattern of COG0787 is -----q-cEBrhuj--ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB000821 (Alanine racemase) with a combined E-value of 1.3e-74. IPB000821A 37-47 IPB000821B 58-85 IPB000821C 126-138 IPB000821D 202-228 IPB000821E 258-288 IPB000821F 341-366","Residues 124-315 are 36% similar to a (ALANINE PYRIDOXAL RACEMASE ISOMERASE) protein domain (PD401882) which is seen in ALR1_ECOLI.Residues 13-364 are 53% similar to a (RACEMASE ALANINE ISOMERASE PYRIDOXAL) protein domain (PD003767) which is seen in Q9CH94_LACLA.Residues 11-83 are 56% similar to a (ALANINE PYRIDOXAL RACEMASE ISOMERASE) protein domain (PD186147) which is seen in Q9S3V7_STRPN.Residues 315-366 are 71% similar to a (ALANINE PHOSPHATE PYRIDOXAL RACEMASE) protein domain (PD335497) which is seen in Q9S3V7_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 09:47:25 2002","Wed Mar 6 09:45:43 2002","Wed Oct 16 08:19:51 2002","Wed Oct 16 08:19:51 2002","Wed Mar 6 09:45:43 2002","Wed Mar 6 09:45:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1670 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 09:47:25 2002","Wed Mar 6 09:45:43 2002","pdb|1SFT|A Chain A, Alanine Racemase >gi|3891941|pdb|1BD0|A Cha... 310 2e-085pdb|2SFP|A Chain A, Alanine Racemase With Bound Propionate Inhi... 308 8e-085","SMU.1834c","","Residues 8 to 229 (E-value = 6.1e-81) place SMu1670 in the Ala_racemase_N family which is described as Alanine racemase, N-terminal domain (PF01168)Residues 242 to 367 (E-value = 3.2e-69) place SMu1670 in the Ala_racemase_C family which is described as Alanine racemase, C-terminal domain (PF00842)","Wed Mar 6 09:45:43 2002","","","","Kanda-Nambu K, Yasuda Y, Tochikubo K.Isozymic nature of spore coat-associated alanine racemase of Bacillus subtilis.Amino Acids. 2000;18(4):375-87.PMID: 10949920Shaw JP, Petsko GA, Ringe D.Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution.Biochemistry. 1997 Feb 11;36(6):1329-42.PMID: 9063881 ","","Wed Mar 6 09:54:58 2002","1","","","SMU.1834c","459" "SMu1671","1731954","1731595","360","ATGATAATAGGACACGGAATTGATTTACAAGATATTGCTGCTGTTCAGAGAGCTCATGAGAGAAGTTCACGCTTTGCCAGCAAAGTTTTAACATTTAAAGAATTAGAAATTTTCACTAGTCTCAAAGGTAGGCGTCAAGTAGAGTATTTAGCAGGACGTTGGGCTGCTAAAGAAGCCTTTTCAAAGGCTTATGGCAGTGGCATTGGTTCTTTGCGCTTTCAAGATTTAGAAATTTTGGCTAATAATAAAGGAGCACCGATTTTTACAAAGTCTCCCTTTTCGGGAAATATTTTTATCAGTATTTCTCATTCTAAAAATTATGTTGAGGCCAGTGTTATTTTGGAGGAGAATAACTTATGA","10.20","3.71","13201","MIIGHGIDLQDIAAVQRAHERSSRFASKVLTFKELEIFTSLKGRRQVEYLAGRWAAKEAFSKAYGSGIGSLRFQDLEILANNKGAPIFTKSPFSGNIFISISHSKNYVEASVILEENNL","1731611","For other 'acp' genes see SMu0023 (ACP),(acpP); SMu1589 (acp) and SMu1376 (acpA).","acyl carrier protein synthase","Cytoplasm","Matches in gapped BLAST to holo-(acyl-carrier protein) synthases. Residues 1-118 are 62% similar to gi|15901533 from S.pneumoniae. Residues 1-116 are 62% similar to gi|15675638 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1685 (6e-38).","

InterPro
IPR002582
Family

Holo-acyl carrier protein synthase
TIGR00516	$\"[1-119]T$	acpS

InterPro
IPR004568
Domain

Phosphopantethiene-protein transferase
PD004282	$\"[8-116]T$	ACPS
TIGR00556	$\"[1-117]T$	pantethn_trn

InterPro
IPR008278
Domain

4'-phosphopantetheinyl transferase
PF01648	$\"[6-73]T$	ACPS
SSF56214	$\"[1-117]T$	4-PPT_transf

noIPR
unintegrated

unintegrated
G3DSA:3.90.470.20	$\"[1-119]T$	G3DSA:3.90.470.20

","BeTs to 12 clades of COG0736COG name: Acyl-carrier protein synthaseFunctional Class: IThe phylogenetic pattern of COG0736 is ----Yqv-ebr-uj-polinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002582 (Holo-acyl carrier protein synthase) with a combined E-value of 6.8e-21. IPB002582A 4-15 IPB002582B 50-65 IPB002582C 75-86 IPB002582D 97-105","Residues 1-117 are 63% similar to a (SYNTHASE HOLO-ACYL-CARRIER TRANSFERASE) protein domain (PD004282) which is seen in Q9F7T5_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:17:51 2002","Wed Mar 6 09:57:10 2002","Wed Oct 16 08:17:51 2002","Wed Apr 3 10:56:35 2002","Wed Mar 6 09:57:10 2002","Wed Mar 6 09:57:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1671 is paralogously related (blast p-value < 1e-3) to SMu1217, a predicted phosphopantetheinyl transferase.","Wed Mar 6 10:17:30 2002","","No significant hits to the NCBI PDB database.","SMU.1835c","","Residues 6 to 73 (E-value = 7.1e-14) place SMu1671 in the ACPS family which is described as 4'-phosphopantetheinyl transferase superfamily (PF01648)","Wed Oct 16 08:17:51 2002","","","Chirgadze,N.Y., Briggs,S.L., McAllister,K.A., Fischl,A.S. andZhao,G.Crystal structure of Streptococcus pneumoniae acyl carrier proteinsynthase: an essential enzyme in bacterial fatty acid biosynthesisEMBO J. 19 (20), 5281-5287 (2000)PubMed: 11032795","Xu GY, Tam A, Lin L, Hixon J, Fritz CC, Powers R.Solution structure of B. subtilis acyl carrier protein.Structure (Camb). 2001 Apr 4;9(4):277-87.PMID: 11525165Parris KD, Lin L, Tam A, Mathew R, Hixon J, Stahl M, Fritz CC, Seehra J, Somers WS.Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in threeactive sites.Structure Fold Des. 2000 Aug 15;8(8):883-95.PMID: 10997907 ","Wed Apr 3 10:57:09 2002","Wed Mar 6 10:16:41 2002","1","","","SMU.1835c","970" "SMu1672","1733258","1732224","1035","ATGGGTATTCATCAAAAAAGCAAAACCATAGATCTTTTCACGGTTAAACAAGGCACGCAATTAAAAGGTCAGGATTTGGCTAAGAAAGAAGCACGTGATCGTGAATTGGTTTCCATTATCAAGGGAGAGGACAACCGTTTACTCTTGATTATTGGTCCTTGTTCATCAGATAATGAAGAAGCTGTTCTTGAGTATGCTAAACGTCTTGCTAAATTGCAGGAAGAAGTTAAAGATCGCATCTTTATGGTGATGCGTGTTTATACGGCAAAGCCACGTACTAATGGTGATGGTTATAAAGGCCTCATTCATCAACCAAATACTTCTAAATTGCCAGATTTGATTAATGGCATTCATGCTGTTCGTAATTTGCATTATCGTGTGATTACTGAGACAGGATTGACAACAGCAGATGAAATGCTTTACCCTTCTAATCTTGTCTTAGTAGATGATTTGGTTTCTTATCATGCTGTTGGTGCTCGTTCGGTTGAAGATCAGGAACATCGCTTTGTGGCTTCAGGCATTGATGTGCCTACTGGCATGAAAAATCCAACGTCTGGTAATCTCAAGGTTATGCTTAATGCTTTACATGCAGCACAAAATTCACAAAATTTTATCTATAATGGAGCAGAAGTAGAAACAGACGGCAATTCCTTGGCTCATGTTATTTTGCGCGGAGGCAGCAATGAGCATGGTGACTATGAACCTAATTATTATTATGACGTTCTCTTAAAACTGATCCAACAGTATGAAAATATGAATTTAATCAATCCCTTTATTGTTGTTGATACCAATCATGATAACTCTGGCAAAAATTATTTGGAACAAGTAAGAATTGTTCGGCAAACCCTTATTAACCGTGACTGGAATGATAAAATCAATAAGTATGTTCGCGGCTTTATGATTGAATCTTATCTAGAAGATGGTCGTCAGGATAAGCCAGAAGTTTTTGGCAAGTCTATTACGGATCCTTGTTTGGGTTGGGAAAATACTCAACAGTTGATTTATGAGATTTACCATACTCTCAAAGCAAAATAA","6.40","-3.43","39084","MGIHQKSKTIDLFTVKQGTQLKGQDLAKKEARDRELVSIIKGEDNRLLLIIGPCSSDNEEAVLEYAKRLAKLQEEVKDRIFMVMRVYTAKPRTNGDGYKGLIHQPNTSKLPDLINGIHAVRNLHYRVITETGLTTADEMLYPSNLVLVDDLVSYHAVGARSVEDQEHRFVASGIDVPTGMKNPTSGNLKVMLNALHAAQNSQNFIYNGAEVETDGNSLAHVILRGGSNEHGDYEPNYYYDVLLKLIQQYENMNLINPFIVVDTNHDNSGKNYLEQVRIVRQTLINRDWNDKINKYVRGFMIESYLEDGRQDKPEVFGKSITDPCLGWENTQQLIYEIYHTLKAK","1732240","For other 'aro' genes see SMu0705 (aroD); SMu0706 (aroE); SMu0707 (aroB); SMu0708 (aroC); SMu0711 (aroA); SMu0712 (aroK) and SMu1673 (aroH) (aroG).","phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthase)","Cytoplasm","Matches in gapped BLAST to phospho-2-dehydro-3-deoxyheptonate aldolase sequences. Residues 1-341 are 74% similar to gi|15901534 from S.pneumoniae. Residues 1-338 are 72% similar to gi|15672098 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1686 (1e-121).","

InterPro
IPR006218
Domain

DAHP synthetase I/KDSA
PF00793	$\"[35-335]T$	DAHP_synth_1

InterPro
IPR006219
Family

Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 1
PIRSF001361	$\"[1-344]T$	DAHP_synthase
PTHR21225	$\"[34-344]T$	AroFGH

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-344]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51569	$\"[1-344]T$	SSF51569

InterPro
IPR006218
Domain

DAHP synthetase I/KDSA
PF00793	$\"[35-335]T$	DAHP_synth_1

InterPro
IPR006219
Family

Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 1
PIRSF001361	$\"[1-343]T$	DAHP_synthase
PTHR21225	$\"[34-343]T$	AroFGH

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-341]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51569	$\"[1-341]T$	SSF51569

","BeTs to 8 clades of COG0722COG name: DAHP synthase/3-Deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthaseFunctional Class: E,MThe phylogenetic pattern of COG0722 is ----YqvcEb-Huj----INxNumber of proteins in this genome belonging to this COG is 2","***** IPB001785 (DAHP synthetase class I) with a combined E-value of 6.5e-39. IPB001785B 33-66 IPB001785C 82-122 IPB001785D 132-183 IPB001785E 197-225 IPB001785F 259-302 IPB001785G 316-337","Residues 24-339 are 76% similar to a (ALDOLASE PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE DAHP) protein domain (PD005060) which is seen in Q9CJ84_LACLA.Residues 40-273 are 22% similar to a (ALDOLASE SYNTHETASE) protein domain (PD005860) which is seen in Q9K7W6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 18 16:32:03 2006","Mon Sep 18 16:32:03 2006","Mon Sep 18 16:32:03 2006","Thu Apr 11 13:20:52 2002","Wed Mar 6 10:28:45 2002","Wed Mar 6 10:28:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1673 is paralogously related (blast p-value < 1e-3) to SMu1672, also a predicted DAHP synthase.","Wed Mar 6 10:33:07 2002","Mon Sep 18 16:32:03 2006","pdb1GG1A Chain A, Crystal Structure Analysis Of Dahp Synthase... 187 2e-048pdb1GG1A Chain A, Crystal Structure Analysis Of Dahp Synthase... 473 1e-134","SMU.1837c","","Residues 35 to 335 (E-value = 1.1e-29) place SMu1673 in the DAHP_synth_1 family which is described as DAHP synthetase I family (PF00793)","Wed Mar 6 10:28:45 2002","","","","","","","1","","","SMU.1837c","460" "SMu1674","1736830","1734311","2520","ATGGCAAATATTCTACGCACTATCATTGAAAATGATAAAGGCGAAGTAAGAAAGTTAACAAAAATAGCAAAAAAAGTTGAAGGTTATGCTAATGAAATGGAGGCACTTTCAGACGAAGAACTTCAGGCAAAGACTGACGAATTTAAAGAACGCTATCAAAATGGTGAGACCTTGGATGATTTACTTCCTGAGGCTTTTGCTGTTGTTCGTGAAGCCTCAAAACGCGTTTTAGGTCTCTATCCTTATCGTGTCCAAATCATGGGCGGTGTTGTCCTTCATCATGGCGACGTTCCAGAAATGCGCACTGGTGAGGGGAAGACCTTAACGGCTACCATGCCTGTTTACCTTAATGCCTTGGCTGGCGAGGGCGTTCATGTTGTTACTGTTAATGAATATCTAGCAACACGTGATGCAACTGAAATGGGAGAATTATATTCATGGTTGGGACTGTCTGTTGGAATTAATTTAGCGGCCAAGTCTTCTAGTGAAAAACGTGAAGCTTATAACTGTGATATTACTTATTCAACTAATGCTGAGATTGGTTTTGATTATCTTCGTGACAATATGGTTGTTCGCAAAGAAAATATGGTACAGCGGCCGCTTAATTTTGCTTTAGTTGATGAGGTGGATTCTGTTCTAATTGATGAGGCTAGAACGCCATTAATTGTTTCAGGACCTGTTAGCACAGAAACCAATCAGCTGTATCATCGTGCAGATAGTTTTGTAAAAACCCTATCAGAAGATGATTATGCTATTGATACGCCTACTAAAACGATTGGCTTAAAAGATTCAGGAATTGATAAAGCAGAAGAGTATTTCCATCTAGAAAATCTTTACGACATTGATAATGTGGCTTTGACCCACTATATTGACAATGCTTTGCGCGCTAACTACATTATGTTACTTGATATTGATTATGTGGTTAGTGAAGAACAGGAAATTCTAATTGTTGACCAATTTACTGGTCGTACAATGGAAGGGCGTCGTTTTTCGGATGGTCTCCACCAAGCTATTGAAGCAAAAGAGGGGGTACCAATTCAGGATGAGTCTAAAACCAGTGCTTCCATTACCTATCAAAATATGTTTCGCATGTATAAAAAGTTAGCGGGAATGACGGGGACTGCGAAGACAGAAGAAGAGGAATTTCGTGAAATTTATAATATGCGCATTATTCCCATTCCAACCAATCGTCCGGTAGCCCGTATTGATCATCAGGACTTGCTCTACCCAACACTTGAAGCAAAATTTAGAGCTGTTGTTGCTGATGTTAAGGAACGCCATGAAAAGGGACAGCCTGTTTTGGTTGGTACTGTTGCTGTCGAAACATCAGATTTGATTTCAAAAATGCTAGTTCAAGCAGGTGTTCCTCACGAAGTTCTTAATGCTAAAAATCACTTTAAAGAAGCTCAGATTATTATGAATGCGGGTCAACGTGGTGCTGTTACCATTGCCACCAACATGGCAGGACGCGGTACTGATATTAAGTTGGGCGAGGGTGTACGTGAGCTCGGCGGTCTTTGTGTTATTGGGACGGAACGTCATGAAAGCCGTCGGATTGACAATCAATTACGTGGACGTTCTGGCCGTCAGGGTGATCCTGGTGAGTCACAATTCTATCTCTCTTTAGAAGATGAATTAATGCGTCGTTTTGGTTCCGAGCGTATCAAAGCTTTTCTTGATCGGTTTATTGAGGAAGATAATGATGTGGTGATTAAATCACGCATGCTAACCAATCAAGTTGAATCAGCTCAAAGACGTGTTGAAGGAAACAACTATGATACTCGTAAGCAAGTTCTTCAATATGATGATGTTATGCGTGAACAGCGTGAGATTATCTATGCTGAGCGTTACGATGTTATCACAGCAGAACGTGACCTTGCCCCAGAGATTAAGGCTATAATTAAGCGAACAATTGAACGCACTGTGGACTCTCATAGTCAATTGGATCGTAAGGAAAGCCTAGATGCTATCCTTAACTTTGCTAAAACAAATCTTTTACCAGAAGACACTATCAGTTTACATGATATAGAAGATTTAAACTATGAAGATATTAAGGATCTGCTCTATGATGCAGCTCTTAAAAATTATGACCGTCAAATTGCTAAACTTCGTGATGAAGAGGCTGTTCGAGAGTTCCAGAAAGTGTTGATCTTGATGGTTGTTGATAATAAATGGACAGATCATATTGATGCTCTGGATCAACTGCGCAGTTCAGTTGGTTTACGTGGTTACGCGCAGAATAATCCTATTGTTGAATATCAATCAGAAGGTTTCAGGATGTTCCAAGATATGATTGGTGCTATTGAATTTGATGTGACACGTACCATGATGAAGGCGCAGATTCATGAACAAGAACGTGAGAAAGAAACTGAAAGTAGGACGACAGCTGAGCAAAATATTTCAGCACAGTCTACTATTTCTCCACAGGATCCAATCTTTAAGAATGTGGGCCGTAATGATAAATGTCCATGTGGTTCAGGTAAGAAGTTTAAAAACTGCCATGGACGCAAGCGATTTTAA","5.00","-30.00","95439","MANILRTIIENDKGEVRKLTKIAKKVEGYANEMEALSDEELQAKTDEFKERYQNGETLDDLLPEAFAVVREASKRVLGLYPYRVQIMGGVVLHHGDVPEMRTGEGKTLTATMPVYLNALAGEGVHVVTVNEYLATRDATEMGELYSWLGLSVGINLAAKSSSEKREAYNCDITYSTNAEIGFDYLRDNMVVRKENMVQRPLNFALVDEVDSVLIDEARTPLIVSGPVSTETNQLYHRADSFVKTLSEDDYAIDTPTKTIGLKDSGIDKAEEYFHLENLYDIDNVALTHYIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVPIQDESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREIYNMRIIPIPTNRPVARIDHQDLLYPTLEAKFRAVVADVKERHEKGQPVLVGTVAVETSDLISKMLVQAGVPHEVLNAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDELMRRFGSERIKAFLDRFIEEDNDVVIKSRMLTNQVESAQRRVEGNNYDTRKQVLQYDDVMREQREIIYAERYDVITAERDLAPEIKAIIKRTIERTVDSHSQLDRKESLDAILNFAKTNLLPEDTISLHDIEDLNYEDIKDLLYDAALKNYDRQIAKLRDEEAVREFQKVLILMVVDNKWTDHIDALDQLRSSVGLRGYAQNNPIVEYQSEGFRMFQDMIGAIEFDVTRTMMKAQIHEQEREKETESRTTAEQNISAQSTISPQDPIFKNVGRNDKCPCGSGKKFKNCHGRKRF","1734327","For other 'sec' genes see SMu1822 (secY) and SMu1463 (secG).","preprotein translocase subunit SecA","Cytoplasm, Membrane","Matcches in gapped BLAST to secA proteins. Residues 1-837 are 83% similar to gi13346810 from S.gordonii.Residues 1-839 are 82% similar to gi15675639 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1687 (0.0).","

InterPro
IPR000185
Family

SecA protein
PR00906	$\"[61-85]T$ $\"[99-113]T$ $\"[115-125]T$ $\"[168-188]T$ $\"[320-342]T$ $\"[357-374]T$ $\"[394-407]T$	SECA
TIGR00963	$\"[26-768]T$	secA
PS01312	$\"[481-496]T$	SECA

InterPro
IPR001650
Domain

Helicase, C-terminal
PF00271	$\"[449-531]T$	Helicase_C
PS51194	$\"[415-570]T$	HELICASE_CTER

InterPro
IPR004027
Domain

SEC-C motif
PF02810	$\"[818-838]T$	SEC-C

InterPro
IPR011115
Domain

SecA DEAD-like
PF07517	$\"[5-383]T$	SecA_DEAD

InterPro
IPR011116
Domain

SecA Wing and Scaffold
PF07516	$\"[570-781]T$	SecA_SW

InterPro
IPR011130
Domain

SecA preprotein cross-linking region
PF01043	$\"[226-339]T$	SecA_PP_bind

InterPro
IPR014018
Domain

SecA motor DEAD
PS51196	$\"[1-571]T$	SECA_MOTOR_DEAD

InterPro
IPR014021
Domain

Helicase superfamily 1 and 2 ATP-binding
PS51192	$\"[87-245]T$	HELICASE_ATP_BIND_1

noIPR
unintegrated

unintegrated
G3DSA:1.10.3060.10	$\"[601-781]T$	G3DSA:1.10.3060.10
G3DSA:3.40.50.300	$\"[11-397]T$ $\"[398-571]T$	G3DSA:3.40.50.300
SSF52540	$\"[1-396]T$ $\"[397-571]T$	SSF52540
SSF81767	$\"[225-349]T$	SSF81767
SSF81886	$\"[573-826]T$	SSF81886

","BeTs to 12 clades of COG0653COG name: Preprotein translocase subunit SecA (ATPase, RNA helicase)Functional Class: NThe phylogenetic pattern of COG0653 is -----qvcebRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000185 (SecA protein) with a combined E-value of 0. IPB000185A 70-115 IPB000185B 116-153 IPB000185C 168-189 IPB000185D 203-222 IPB000185E 294-347 IPB000185F 367-419 IPB000185G 459-499 IPB000185H 500-548 IPB000185I 575-621 IPB000185J 716-761","Residues 505-622 are 77% similar to a (TRANSPORT TRANSLOCASE PREPROTEIN SUBUNIT TRANSLOCATION) protein domain (PD000905) which is seen in Q9CJ85_LACLA.Residues 813-836 are 91% similar to a (TRANSPORT TRANSLOCASE PREPROTEIN SUBUNIT) protein domain (PD243435) which is seen in Q9CJ85_LACLA.Residues 625-714 are 35% similar to a (PROTEOME SECA TRANSLOCASE SUBUNIT) protein domain (PD393068) which is seen in Q9CJ85_LACLA.Residues 630-715 are 35% similar to a (TRANSPORT SUBUNIT PREPROTEIN TRANSLOCASE) protein domain (PD042417) which is seen in SECA_LISMO.Residues 716-778 are 74% similar to a (TRANSPORT PREPROTEIN TRANSLOCASE SUBUNIT) protein domain (PD042419) which is seen in Q9CJ85_LACLA.Residues 695-762 are 34% similar to a (TRANSPORT TRANSLOCASE SUBUNIT CHLOROPLAST) protein domain (PD139635) which is seen in SECA_ODOSI.Residues 422-490 are 81% similar to a (TRANSPORT TRANSLOCASE PREPROTEIN SUBUNIT TRANSLOCATION) protein domain (PD296196) which is seen in Q9CJ85_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 16 08:29:24 2006","Wed Mar 6 10:41:54 2002","Wed Aug 16 08:29:24 2006","Tue Apr 9 13:58:37 2002","Wed Mar 6 10:41:54 2002","Wed Mar 6 10:41:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1674 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:58:37 2002","","No significant hits to the NCBI PDB database.","SMU.1838c","","Residues 5 to 419 (E-value = 3.3e-268) place SMu1674 in the SecA_protein family which is described as SecA protein, amino terminal region (PF01043)Residues 818 to 838 (E-value = 1.6e-08) place SMu1674 in the SEC-C family which is described as SEC-C motif (PF02810)","Wed Aug 16 08:29:24 2006","","","","Baud C, Karamanou S, Sianidis G, Vrontou E, Politou AS, Economou A.Allosteric communication between signal peptides and the SecA protein DEAD motor ATPase domain.J Biol Chem. 2002 Feb 1 [epub ahead of print]PMID: 11825907 [Weinkauf S, Hunt JF, Scheuring J, Henry L, Fak J, Oliver DB, Deisenhofer J.Conformational stabilization and crystallization of the SecA translocation ATPase from Bacillus subtilis.Acta Crystallogr D Biol Crystallogr. 2001 Apr;57(Pt 4):559-65.PMID: 11264585","","Wed Mar 6 10:41:54 2002","1","","","SMU.1838c","173" "SMu1675","1737958","1737008","951","ATGGCAGAACCTTTGTTTTTACAATCACAAATGCATAAAAAAATCTGGGGCGGCAATCGGCTCAGAAAAGAATTTGGTTATGACATTCCTAGTGAAACGACGGGAGAATATTGGGCGATTTCTGCGCATCCTAATGGAGTGTCTGTTGTTAAAAATGGTGTTTATAAAGGTGTCCCCTTAGATGAATTATATGCAGAGCATAGAGAACTGTTCGGCAATAGCAAGAGTTCTGTTTTTCCGCTTTTAACTAAAATCTTAGATGCCAACGATTGGCTTAGTGTTCAAGTTCATCCTGATAATGCTTATGCTTTGGAACATGAAGGTGAGTTAGGAAAGACAGAATGTTGGTATGTCATTTCAGCTGATGAAGGTGCTGAAATTATCTATGGACACGAAGCTAAATCTAAAGAAGAATTGCGTCAAATGATTGCCGCGGGCGATTGGGATCACCTTTTGACAAAGATTCCTGTTAAAGCTGGGGATTTCTTCTATGTTCCTAGTGGTACTATGCATGCCATTGGTAAGGGAATTATGATTTTGGAGACACAGCAGTCAAGTGATACGACCTACCGCGTTTATGATTTTGATCGCAAAGATGATCAAGGACGAAAACGAGCTCTTCATATTGAACAGTCAATTGATGTTTTGACAATTGGTAAGCCGGCAAATGCGACGCCAGCTTGGTTATCTCTACAAGGCCTTGAAACAACGGTCTTGGTTTCCAGCCCTTTCTTTACTGTCTATAAATGGCAGATTAGTGGTTCCGTCAAAATGCAGCAGACAGCTCCTTACCTTTTGGTGAGTGTCCTTGCTGGACAAGGTCGTATTACGGTTGGTTTAGAACAATATGCCTTAAGAAAAGGAGATCATCTTATTCTTCCTAATACTATTAAATCTTGGCAGTTTGATGGTGATTTAGAAATAATTGCCAGCCATTCCAATGAATGTTAA","5.80","-7.43","35361","MAEPLFLQSQMHKKIWGGNRLRKEFGYDIPSETTGEYWAISAHPNGVSVVKNGVYKGVPLDELYAEHRELFGNSKSSVFPLLTKILDANDWLSVQVHPDNAYALEHEGELGKTECWYVISADEGAEIIYGHEAKSKEELRQMIAAGDWDHLLTKIPVKAGDFFYVPSGTMHAIGKGIMILETQQSSDTTYRVYDFDRKDDQGRKRALHIEQSIDVLTIGKPANATPAWLSLQGLETTVLVSSPFFTVYKWQISGSVKMQQTAPYLLVSVLAGQGRITVGLEQYALRKGDHLILPNTIKSWQFDGDLEIIASHSNEC","1737024","For other 'man' genes see SMu1707 (manL) and SMu1708 (manM).","mannose-6-phosphate isomerase","Cytoplasm","This sequence corresponds to the previously published gi|2499711 in GenBank. In addition, residues 1-315 are 72% similar to gi|15675642 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1688 (1e-140).","

InterPro
IPR001250
Family

Mannose-6-phosphate isomerase, type I
PF01238	$\"[5-313]T$	PMI_typeI
TIGR00218	$\"[4-312]T$	manA

InterPro
IPR011051
Domain

Cupin, RmlC-type
SSF51182	$\"[1-313]T$	RmlC_like_cupin

InterPro
IPR014628
Family

Mannose-6-phosphate isomerase, Firmicutes type, short form
PIRSF036894	$\"[4-314]T$	PMI_Firm_short

InterPro
IPR014710
Domain

RmlC-like jelly roll fold
G3DSA:2.60.120.10	$\"[4-225]T$	RmlC-like_jellyroll

noIPR
unintegrated

unintegrated
PTHR18964	$\"[17-313]T$	PTHR18964
PTHR18964:SF1	$\"[17-313]T$	PTHR18964:SF1

","BeTs to 6 clades of COG1482COG name: Phosphomannose isomeraseFunctional Class: GThe phylogenetic pattern of COG1482 is a---y-v-eBr-----o----Number of proteins in this genome belonging to this COG is 1","***** IPB001250 (Mannose-6-phosphate isomerase type I) with a combined E-value of 1e-51. IPB001250A 7-17 IPB001250B 79-95 IPB001250C 96-127 IPB001250D 151-195","Residues 250-312 are identical to a (ISOMERASE PROTEOME MANNOSE-6-PHOSPHATE) protein domain (PD328250) which is seen in MANA_STRMU.Residues 217-249 are identical to a (ISOMERASE PHOSPHOMANNOSE) protein domain (PD227093) which is seen in MANA_STRMU.Residues 237-312 are 52% similar to a (ISOMERASE PROTEOME COMPLETE) protein domain (PD393905) which is seen in Q9CHG2_LACLA.Residues 16-276 are 24% similar to a (DOMAIN OF UNKNO N) protein domain (PD325390) which is seen in Q9S1S8_STRCO.Residues 10-216 are 99% similar to a (ISOMERASE PROTEOME COMPLETE) protein domain (PD277863) which is seen in MANA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:13:49 2002","Wed Mar 6 10:43:00 2002","Wed Oct 16 08:13:49 2002","Thu Apr 11 11:02:57 2002","Wed Mar 6 10:43:00 2002","Wed Mar 6 10:43:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1675 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 10:49:45 2002","","No significant hits to the NCBI PDB database.","SMU.1839c","","Residues 5 to 313 (E-value = 3.9e-156) place SMu1675 in the PMI_typeI family which is described as Phosphomannose isomerase type I (PF01238)","Wed Mar 6 10:43:00 2002","","","Sato,Y., Yamamoto,Y., Kizaki,H. and Kuramitsu,H.K.Isolation and sequence analysis of the pmi gene encodingphosphomannose isomerase of Streptococcus mutansFEMS Microbiol. Lett. 114 (1), 61-66 (1993)PubMed: 8293960","","Thu Apr 11 11:02:57 2002","","1","","","SMU.1839c","461" "SMu1676","1739008","1738127","882","ATGTCTAAATTATATGGCAGCATCGAAGCTGGCGGAACAAAATTTGTCTGTGCTGTAGGTGATGAAAATTTTCAAATTTTAGAAAAAGTTCAGTTCCCAACAACAACACCTTATGAAACAATAGAAAAAACAGTTGCTTTCTTTAAAAAATTTGAAGCTGATTTAGCCAGTGTTGCCATTGGTTCTTTTGGCCCTATTGATATTGATCAAAATTCAGACACTTATGGTTACATTACTTCAACACCAAAGCCAAACTGGGCTAACGTTGATTTTGTCGGCTTAATTTCTAAAGATTTTAAAATTCCATTTTACTTTACGACAGATGTTAATTCTTCTGCTTATGGGGAAACAATTGCTCGTTCAAATGTTAAAAGTCTGGTTTATTATACTATTGGAACAGGCATTGGAGCAGGGACTATTCAAAATGGCGAATTCATTGGCGGTATGGGACATACGGAAGCTGGACACGTTTACATGGCTCCGCATCCCAATGATGTTCATCATGGTTTTGTAGGCACCTGTCCTTTCCATAAAGGCTGTTTAGAAGGACTTGCAGCGGGTCCTAGCTTAGAGGCTCGTACTGGTATTCGTGGTGAGTTAATTGAGCAAAACTCAGAAGTTTGGGATATTCAGGCATACTACATTGCTCAGGCGGCTATTCAAGCGACTGTCCTTTATCGTCCGCAAGTCATTGTATTTGGCGGAGGCGTTATGGCACAAGAACATATGCTCAATCGGGTTCGTGAAAAATTTACTTCACTTTTGAATGACTATCTTCCAGTTCCAGATGTTAAAGATTATATTGTGACACCAGCTGTTGCAGAAAATGGTTCAGCAACATTGGGAAATCTCGCTTTAGCTAAAAAGATAGCAGCGCGTTAA","5.40","-6.45","31698","MSKLYGSIEAGGTKFVCAVGDENFQILEKVQFPTTTPYETIEKTVAFFKKFEADLASVAIGSFGPIDIDQNSDTYGYITSTPKPNWANVDFVGLISKDFKIPFYFTTDVNSSAYGETIARSNVKSLVYYTIGTGIGAGTIQNGEFIGGMGHTEAGHVYMAPHPNDVHHGFVGTCPFHKGCLEGLAAGPSLEARTGIRGELIEQNSEVWDIQAYYIAQAAIQATVLYRPQVIVFGGGVMAQEHMLNRVREKFTSLLNDYLPVPDVKDYIVTPAVAENGSATLGNLALAKKIAAR","1738143","For other 'scr' genes see SMu0094 (scrR); SMu1677 (scrA); SMu1678 (scrB) and SMu1679 (scrR).","fructokinase","Cytoplasm","This sequence corresponds to the previously published gi|585974 in GenBank. In addition, residues 1-291 are 68% similar to gi|15675643 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1689 (1e-123).","

InterPro
IPR000600
Family

ROK
PF00480	$\"[7-190]T$	ROK

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.160	$\"[108-284]T$	G3DSA:3.30.420.160
PTHR18964	$\"[61-287]T$	PTHR18964
PTHR18964:SF10	$\"[61-287]T$	PTHR18964:SF10

","BeTs to 3 clades of COG1940COG name: Transcriptional regulators of NagC/XylR familyFunctional Class: KThe phylogenetic pattern of COG1940 is a-t--qVcEBRH----O----Number of proteins in this genome belonging to this COG is 2","***** IPB000600 (ROK family) with a combined E-value of 2.4e-15. IPB000600A 7-14 IPB000600B 102-116 IPB000600C 131-140 IPB000600D 151-157 IPB000600E 173-182","Residues 141-288 are 91% similar to a (KINASE FRUCTOKINASE TRANSFERASE PROTEOME) protein domain (PD151308) which is seen in SCRK_STRMU.Residues 3-84 are identical to a (KINASE FRUCTOKINASE TRANSFERASE PROTEOME) protein domain (PD212369) which is seen in SCRK_STRMU.Residues 85-129 are identical to a (PROTEOME COMPLETE REPRESSOR XYLOSE) protein domain (PD212372) which is seen in SCRK_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:13:07 2002","Wed Mar 6 10:54:30 2002","Wed Oct 16 08:13:07 2002","Thu Apr 11 13:33:49 2002","Wed Mar 6 10:54:30 2002","Wed Mar 6 10:54:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1676 is paralogously related (blast p-value < 1e-3) to SMu0493, a predicted glucose kinase.","Wed Mar 6 10:58:16 2002","","No significant hits to the NCBI PDB database.","SMU.1840c","","Residues 7 to 190 (E-value = 3.9e-96) place SMu1676 in the ROK family which is described as ROK family (PF00480)","Wed Mar 6 10:54:30 2002","","","Sato,Y., Yamamoto,Y., Kizaki,H. and Kuramitsu,H.K.Isolation, characterization and sequence analysis of the scrK geneencoding fructokinase of Streptococcus mutansJ. Gen. Microbiol. 139 (Pt 5), 921-927 (1993)PubMed: 8336109","Thompson J, Sackett DL, Donkersloot JA.Purification and properties of fructokinase I from Lactococcus lactis. Localization of scrK on the sucrose-nisin transposon Tn5306.J Biol Chem. 1991 Nov 25;266(33):22626-33.PMID: 1658003","Thu Apr 11 13:33:49 2002","Wed Mar 6 11:05:11 2002","1","","","SMU.1840c","462" "SMu1677","1741202","1739208","1995","ATGGATTATAGCAAAGTAGCTAGTGAAGTCATCACAGCTGTTGGTAAAGATAATCTTGTAGCTGCCGCTCACTGTGCGACACGTCTTCGTCTTGTTTTAAAAGATGACAGTAAAGTAGATCAAAAAGCGTTGGATAAAAATGCTGATGTCAAGGGAACTTTTAAAACGGATGGTCAATATCAAGTTATTATTGGCCCTGGTGATGTTAACTTTGTTTATGATGAAATTATTAAACAAACAGGTTTAACAGAAGTCTCAACAGATGATTTGAAAAAGATTGCTGCCAGTGGTAAAAAGTTCAATCCTATTATGGCTTTGATCAAACTGTTGTCTGATATCTTTGTACCAATTATCCCTGCCTTGGTAGCAGGCGGTCTCTTAATGGCTTTAAATAACTTTTTAACTTCAGAAGGTTTATTTGGTACTAAGTCACTGGTTCAACAATTCCCGATTATTAAGGGTTCATCTGACATGATTCAATTAATGTCAGCAGCGCCTTTCTGGTTCTTACCCATTTTGGTTGGGATTTCAGCCGCTAAACGTTTTGGTGCTAACCAATTCTTAGGAGCTTCAATCGGCATGATTATGGTCGCACCGGGGGCAGCAAATATCATTGGTTTAGCAGCTAATGCTCCAATTTCAAAGGCTGCTACTATTGGTGCTTATACAGGATTTTGGAATATTTTTGGGTTGCATGTTACTCAGGCAAGTTATACTTATCAAGTGATTCCAGTACTTGTGGCTGTATGGCTTTTATCTATCTTAGAAAAATTTTTCCATAAGAGATTGCCCTCAGCAGTTGACTTTACCTTTACACCTTTATTGTCAGTTATTATTACTGGATTTTTGACATTTATCGTTATTGGTCCTGTTATGAAAGAAGTTTCTGACTGGCTTACAAATGGAATCGTATGGCTGTATGATACAACGGGATTCCTAGGTATGGGTGTCTTTGGTGCTCTGTATTCACCTGTAGTTATGACTGGTCTCCATCAAAGTTTCCCAGCTATTGAAACCCAACTCATTTCAGCTTTCCAAAATGGTACTGGTCATGGTGACTTTATCTTTGTTACAGCTTCAATGGCCAATGTCGCACAAGGCGCAGCAACCTTTGCAATTTACTTCTTAACAAAAGATAAGAAGATGAAAGGTCTCTCATCTTCTTCAGGTGTGTCAGCGCTTCTTGGTATTACAGAACCTGCTCTTTTTGGGGTGAATTTGAAATATCGTTTCCCATTCTTTTGTGCTCTGATTGGCTCAGCTAGTGCTGCAGCAATTGCGGGCTTACTTCAAGTTGTAGCGGTTTCTCTTGGTTCGGCAGGTTTTCTTGGTTTCCTTTCTATTAAGGCAAGTTCTATTCCATTTTATGTAGTCTGTGAATTAATCAGTTTTGCTATAGCTTTTGCAGTAACTTATGGCTATGGTAAGACGAAGGCTGTTGATGTCTTTGCTGCTGAAGCTGCTGTCGAAGAAGCTATTGAAGAAGTGCAAGAAATTCCAGAAGAAGCTGCTTCTGCAGCAAATAAGGCACAAGTTACTGATGAAGTTCTTGCGGCTCCTCTTGCTGGTGAAGCTGTTGAATTAACCTCTGTTAATGACCCTGTTTTTTCTAGCGAAGCAATGGGTAAGGGGATTGCTATCAAACCTAGTGGTAATACAGTTTATGCACCGGTTGATGGGACTGTTCAAATTGCTTTTGATACTGGCCATGCTTATGGTATTAAGTCAGACAATGGTGCGGAGATTCTTATTCATATTGGTATTGATACAGTATCAATGGAAGGTAAAGGATTTGAACAAAAAGTTCAAGCAGATCAAAAAATTAAAAAAGGTGACGTTCTCGGAACATTTGATAGTGACAAAATTGCAGAAGCTGGTCTTGATAATACAACAATGTTCATTGTTACTAATACAGCTGATTATGCGTCAGTTGAAACCCTCGCTTCTTCAGGAACTGTTGCTGTAGGTGATAGCTTACTTGAAGTTAAAAAATAA","5.00","-12.42","69981","MDYSKVASEVITAVGKDNLVAAAHCATRLRLVLKDDSKVDQKALDKNADVKGTFKTDGQYQVIIGPGDVNFVYDEIIKQTGLTEVSTDDLKKIAASGKKFNPIMALIKLLSDIFVPIIPALVAGGLLMALNNFLTSEGLFGTKSLVQQFPIIKGSSDMIQLMSAAPFWFLPILVGISAAKRFGANQFLGASIGMIMVAPGAANIIGLAANAPISKAATIGAYTGFWNIFGLHVTQASYTYQVIPVLVAVWLLSILEKFFHKRLPSAVDFTFTPLLSVIITGFLTFIVIGPVMKEVSDWLTNGIVWLYDTTGFLGMGVFGALYSPVVMTGLHQSFPAIETQLISAFQNGTGHGDFIFVTASMANVAQGAATFAIYFLTKDKKMKGLSSSSGVSALLGITEPALFGVNLKYRFPFFCALIGSASAAAIAGLLQVVAVSLGSAGFLGFLSIKASSIPFYVVCELISFAIAFAVTYGYGKTKAVDVFAAEAAVEEAIEEVQEIPEEAASAANKAQVTDEVLAAPLAGEAVELTSVNDPVFSSEAMGKGIAIKPSGNTVYAPVDGTVQIAFDTGHAYGIKSDNGAEILIHIGIDTVSMEGKGFEQKVQADQKIKKGDVLGTFDSDKIAEAGLDNTTMFIVTNTADYASVETLASSGTVAVGDSLLEVKK","1739224","For other 'scr' genes see SMu0094 (scrR); SMu1676 (scrK); SMu1678 (scrB) and SMu1679 (scrR).","PTS system, sucrose-specific IIABC component","Membrane, Cytoplasm","This sequence corresponds to the previously sequenced gi131505, gi153801, and gi97996 in GenBank. In addition, The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0192 (2e-95).","

InterPro
IPR001127
Domain

Phosphotransferase system, sugar-specific permease EIIA 1 domain
PD002243	$\"[515-639]T$	PTS_EIIA
PF00358	$\"[512-644]T$	PTS_EIIA_1
TIGR00830	$\"[517-637]T$	PTBA
PS00371	$\"[579-591]T$	PTS_EIIA_TYPE_1_HIS
PS51093	$\"[533-637]T$	PTS_EIIA_TYPE_1

InterPro
IPR001996
Domain

Phosphotransferase system, EIIB
PD001476	$\"[33-72]T$	Ptrans_EIIB
PF00367	$\"[7-40]T$	PTS_EIIB
PS01035	$\"[18-35]T$	PTS_EIIB_TYPE_1_CYS
PS51098	$\"[3-86]T$	PTS_EIIB_TYPE_1

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[111-420]T$	PTS_EIIC

InterPro
IPR010973
Domain

Phosphotransferase system, sucrose-specific IIBC component
TIGR01996	$\"[2-474]T$	PTS-II-BC-sucr

InterPro
IPR011055
Domain

Duplicated hybrid motif
SSF51261	$\"[508-663]T$	Dup_hybrid_motif

InterPro
IPR011535
Domain

Phosphotransferase system, glucose-like IIB component
TIGR00826	$\"[27-112]T$	EIIB_glc

InterPro
IPR013013
Domain

Phosphotransferase system, EIIC component, type 1
PS51103	$\"[108-492]T$	PTS_EIIC_TYPE_1

noIPR
unintegrated

unintegrated
G3DSA:2.70.70.10	$\"[503-664]T$	G3DSA:2.70.70.10
G3DSA:3.30.1360.60	$\"[2-93]T$	G3DSA:3.30.1360.60
SSF55604	$\"[6-84]T$	SSF55604

","No hits to the COGs database.","***** IPB001127 (Sugar-specific permease, EIIA 1 domain) with a combined E-value of 4.7e-50. IPB001127A 517-551 IPB001127B 556-598***** IPB001996 (PTS (phosphotransferase system) EIIB domain) with a combined E-value of 6.7e-21. IPB001996A 6-40 IPB001996B 56-68","Residues 505-532 are identical to a (COMPONENT IIABC PHOSPHOTRANSFERASE SYSTEM) protein domain (PD135103) which is seen in PTSA_STRMU.Residues 59-300 are 93% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE II ENZYME IIBC) protein domain (PD003077) which is seen in PTSA_STRMU.Residues 7-40 are identical to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIABC) protein domain (PD001476) which is seen in PTSA_STRMU.Residues 317-409 are 86% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIBC IIABC) protein domain (PD024747) which is seen in PTSA_STRMU.Residues 412-476 are 78% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIBC) protein domain (PD229066) which is seen in PTSA_STRMU.Residues 533-637 are identical to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE TRANSPORT PTS IIABC) protein domain (PD002243) which is seen in PTSA_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 10:12:54 2006","Wed Mar 6 11:14:46 2002","Tue Sep 19 10:12:54 2006","Wed Mar 6 11:14:46 2002","Wed Mar 6 11:14:46 2002","Wed Mar 6 11:14:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1677 is paralogously related (blast p-value < 1e-3) to SMu1852, a predicted Phosphotransferase system, trehalose-specific IIBC component, to SMu0890, a predicted beta-glucoside-specific EII permease, to SMu1858, a predicted PTS system, enzyme II, A component and to SMu1451, a predicted PTS system, cellobiose-specific IIC component.","Wed Mar 6 11:31:30 2002","Tue Sep 19 10:12:54 2006","pdb1GGRA Chain A, Complex Of Enzyme Iiaglc And The Histidine-... 122 1e-028pdb1F3G Phosphocarrier Iiiglcfast >gi2914331pdb1F3Z ... 122 1e-028pdb1AX3 Solution Nmr Structure Of B. Subtilis Iiaglc, 16 S... 105 2e-023","SMU.1841c","","Residues 7 to 40 (E-value = 1.9e-18) place SMu1677 in the PTS_EIIB family which is described as phosphotransferase system, EIIB (PF00367)Residues 111 to 420 (E-value = 4.2e-76) place SMu1677 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)Residues 533 to 637 (E-value = 4.3e-72) place SMu1677 in the PTS_EIIA_1 family which is described as phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PF00358)","Tue Sep 19 10:12:54 2006","","","Sato,Y., Poy,F., Jacobson,G.R. and Kuramitsu,H.K.Characterization and sequence analysis of the scrA gene encodingenzyme IIScr of the Streptococcus mutansphosphoenolpyruvate-dependent sucrose phosphotransferase systemJ. Bacteriol. 171 (1), 263-271 (1989)PubMed: 2536656","Hiratsuka K, Wang B, Sato Y, Kuramitsu H.Regulation of sucrose-6-phosphate hydrolase activity in Streptococcus mutans: characterization of the scrR gene.Infect Immun. 1998 Aug;66(8):3736-43.PMID: 9673256Titgemeyer F, Jahreis K, Ebner R, Lengeler JW.Molecular analysis of the scrA and scrB genes from Klebsiella pneumoniae and plasmid pUR400, which encode the sucrose transport protein Enzyme II Scr of the phosphotransferase system and a sucrose-6-phosphate invertase.Mol Gen Genet. 1996 Feb 5;250(2):197-206.PMID: 8628219 Chen YY, Lee LN, LeBlanc DJ.Sequence analysis of scrA and scrB from Streptococcus sobrinus 6715.Infect Immun. 1993 Jun;61(6):2602-10.PMID: 8500898","Tue Sep 19 10:12:54 2006","Wed Mar 6 11:43:38 2002","1","","","SMU.1841c","463" "SMu1678","1741398","1742837","1440","ATGAATTTGCCTCAAAATATCAGATATCGCCGCTATCAAGATTGGACTGAAGAAGAAATAAAAAGTATTAAAACCAATGTAGCTTTGTCTCCTTGGCATACAACGTATCATATAGAACCTAAAACAGGACTCCTTAATGATCCAAACGGTTTTTCCTATTTTAATGGAAAATTTAACCTTTTTTATCAAAATTGGCCATTTGGAGCAGCTCACGGCTTAAAATCTTGGATCCATACTGAAAGTGAAGACTTAGTCCATTTCAAAGAAACAGGTACAGTCCTTTATCCCGATACTTCCCATGACAGCCATGGTGCATACTCGGGCAGTGCCTATGAAATCGGTGATCAGCTTTTTCTCTTTTATACAGGAAATGTCCGAGATGAAAATTGGGTTCGTCATCCACTTCAAATCGGCGCTTTTATGGATAAAAAAGGTAATATCCAAAAATTTACTGATGTCCTTATTAAACAGCCAAATGATGTTACTGAACACTTTCGCGATCCCCAAATTTTTAATTATAAAGGACAATTTTATGCTATTGTTGGAGCACAAAGTCTAGATAAAAAAGGATTTATCAAACTCTATAAAGCTGTTGATAATGATATTAAGAATTGGCAAGAAGTTGGTAATCTAGACTTTGGCGGAAGTAAATCTGAGTATATGATTGAGTGCCCAAATCTTGTTTTTATAAACGAACAGCCTGTCCTGATTTATAGTCCTCAGGGACTCAGTAAATCTGAATTAGATTATCATAATATTTATCCTAATACTTACAAAGTATGTCAATCGTTTGACACAGAAAAGCCTGCCCTAGTTGATGCATCGGAAATTCAAAATCTTGACTTCGGATTTGAATGTTATGCTACCCAAGCTTTCAATGCTCCTGATGGCCGTGTTTATGCTGTCTCATGGATTGGGTTACCAGATATTGATTATCCAAGTGATTCATACGACTATCAAGGAGCTTTGAGCCTCGTCAAAGAGCTAAGCCTTAAACACGGTAAACTCTATCAATATCCCGTTGAAGCTGTTCGTTCATTACGTTCTGAAAAAGAAGCAGTCACTTACAAGCCAGAAACCAATAATACTTATGAATTAGAGTTAACTTTTGACTCTTCATCAGTTAATGAATTGCTCCTTTTTGCTGATAATAAAGGCAATGGTCTAGCTATTACAGTTGATACTAAGATGGGAACCATTCTGATCGATCGCTCTAAAGCAGGGGAGCAATATGCCTTAGAATTTGGAAGCCAACGTTCTTGCTCTATCCAAGCAAAAGAGACTGTTGTCAATATTTTTGTTGACAAATCGATTTTTGAAATTTTTATTAATAAGGGAGAAAAAGTTTTTACTGGACGTGTTTTTCCAAATGACAAACAAACTGGTATTGTGATTAAATCTGGAAAGCCAAGCGGTAATTACTACGAATTGAAATATTAA","5.30","-11.50","54661","MNLPQNIRYRRYQDWTEEEIKSIKTNVALSPWHTTYHIEPKTGLLNDPNGFSYFNGKFNLFYQNWPFGAAHGLKSWIHTESEDLVHFKETGTVLYPDTSHDSHGAYSGSAYEIGDQLFLFYTGNVRDENWVRHPLQIGAFMDKKGNIQKFTDVLIKQPNDVTEHFRDPQIFNYKGQFYAIVGAQSLDKKGFIKLYKAVDNDIKNWQEVGNLDFGGSKSEYMIECPNLVFINEQPVLIYSPQGLSKSELDYHNIYPNTYKVCQSFDTEKPALVDASEIQNLDFGFECYATQAFNAPDGRVYAVSWIGLPDIDYPSDSYDYQGALSLVKELSLKHGKLYQYPVEAVRSLRSEKEAVTYKPETNNTYELELTFDSSSVNELLLFADNKGNGLAITVDTKMGTILIDRSKAGEQYALEFGSQRSCSIQAKETVVNIFVDKSIFEIFINKGEKVFTGRVFPNDKQTGIVIKSGKPSGNYYELKY","1742847","For other 'scr' genes see SMu0094 (scrR); SMu1676 (scrK); SMu1677 (scrA) and SMu1679 (scrR).","sucrose-6-phosphate hydrolase","Cytoplasm","This sequence corresponds to the previously published gi|153804, gi|47259, gi|97999| in GenBank. In addition, residues 1-477 are 71% similar to gi|2126627 from S.sobrinus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1691 (0.0).","

InterPro
IPR001362
Family

Glycoside hydrolase, family 32
SM00640	$\"[37-446]T$	Glyco_32
PS00609	$\"[37-50]T$	GLYCOSYL_HYDROL_F32

InterPro
IPR006232
Family

Sucrose-6-phosphate hydrolase
TIGR01322	$\"[20-457]T$	scrB_fam

InterPro
IPR008985
Domain

Concanavalin A-like lectin/glucanase
SSF49899	$\"[341-478]T$	ConA_like_lec_gl

InterPro
IPR013148
Domain

Glycosyl hydrolases family 32, N-terminal
PF00251	$\"[37-340]T$	Glyco_hydro_32N

InterPro
IPR013189
Domain

Glycosyl hydrolase family 32, C-terminal
PF08244	$\"[368-446]T$	Glyco_hydro_32C

noIPR
unintegrated

unintegrated
G3DSA:2.60.120.560	$\"[333-479]T$	G3DSA:2.60.120.560
SSF75005	$\"[31-340]T$	SSF75005

","BeTs to 3 clades of COG1621COG name: Beta-fructosidases (levanase/invertase)Functional Class: GThe phylogenetic pattern of COG1621 is ----y-v--B-----------Number of proteins in this genome belonging to this COG is 3","***** IPB001362 (Glycoside hydrolase family 32) with a combined E-value of 6.5e-10. IPB001362 36-61","Residues 259-349 are 86% similar to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN PRECURSOR) protein domain (PD000903) which is seen in SCRB_STRMU.Residues 158-265 are 35% similar to a (HYDROLASE SUCRASE SUCROSE-6-PHOSPHATE) protein domain (PD210907) which is seen in SCRB_PEDPE.Residues 165-258 are 73% similar to a (HYDROLASE SUCRASE SUCROSE-6-PHOSPHATE) protein domain (PD414364) which is seen in SCRB_STRMU.Residues 273-405 are 42% similar to a (HYDROLASE PROTEOME COMPLETE) protein domain (PD415477) which is seen in SCRB_LACLA.Residues 166-262 are 33% similar to a (PROTEOME COMPLETE SCRB) protein domain (PD394831) which is seen in Q9CJZ0_PASMU.Residues 83-164 are identical to a (HYDROLASE GLYCOSIDASE SUCROSE-6-PHOSPHATE) protein domain (PD186656) which is seen in SCRB_STRMU.Residues 350-402 are identical to a (HYDROLASE SUCRASE SUCROSE-6-PHOSPHATE) protein domain (PD136407) which is seen in SCRB_STRMU.Residues 166-285 are 33% similar to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN) protein domain (PD186044) which is seen in SCRB_KLEPN.Residues 32-82 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN PRECURSOR) protein domain (PD186045) which is seen in SCRB_STRMU.Residues 76-149 are 40% similar to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN SIGNAL) protein domain (PD336564) which is seen in SCRB_BACSU.Residues 403-475 are identical to a (HYDROLASE GLYCOSIDASE INVERTASE GLYCOPROTEIN) protein domain (PD002161) which is seen in SCRB_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:11:55 2002","Wed Mar 6 11:32:34 2002","Wed Oct 16 08:11:55 2002","Thu Apr 11 13:35:20 2002","Wed Mar 6 11:32:34 2002","Wed Mar 6 11:32:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1678 is paralogously related (blast p-value < 1e-3) to SMu0070, and SMu0071, both predicted fructan hydrolases.","Wed Mar 6 11:45:31 2002","","No significant hits to the NCBI PDB database.","SMU.1843","","Residues 37 to 446 (E-value = 4.7e-214) place SMu1678 in the Glyco_hydro_32 family which is described as Glycosyl hydrolases family 32 (PF00251)","Wed Mar 6 11:32:34 2002","24380204","","Sato,Y. and Kuramitsu,H.K.Sequence analysis of the Streptococcus mutans scrB geneInfect. Immun. 56, 1956-1960 (1988)PubMed: 3397182Sato,Y., Poy,F., Jacobson,G.R. and Kuramitsu,H.K.Characterization and sequence analysis of the scrA gene encodingenzyme IIScr of the Streptococcus mutansphosphoenolpyruvate-dependent sucrose phosphotransferase systemJ. Bacteriol. 171 (1), 263-271 (1989)PubMed: 2536656","Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM.A simple model host for identifying Gram-positive virulence factors.Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10892-7.PMID: 11535834 Hiratsuka K, Wang B, Sato Y, Kuramitsu H.Regulation of sucrose-6-phosphate hydrolase activity in Streptococcus mutans: characterization of the scrR gene.Infect Immun. 1998 Aug;66(8):3736-43.PMID: 9673256Chen YY, Lee LN, LeBlanc DJ.Sequence analysis of scrA and scrB from Streptococcus sobrinus 6715.Infect Immun. 1993 Jun;61(6):2602-10.PMID: 8500898","Thu Apr 11 13:35:20 2002","Wed Mar 6 11:43:05 2002","1","","","SMU.1843","174" "SMu1679","1742840","1743802","963","ATGGTTGCAAAATTAACAGATGTCGCAAAACTCGCTGGCGTAAGTCCAACAACCGTTTCACGCGTGATTAATCGAAAAGGCTATCTCTCTGAAAAAACAATTACTAAAGTACAGGCTGCCATGAAAACTCTAGGATACAAGCCCAATAATCTCGCTCGCAGCCTTCAGGGGAAATCTGCCAAGCTAATTGGACTTATTTTCCCTAATATCAGTCACATCTTCTATTCTGAACTTATTGAATATTTAGAAATAGAGTTGTTTAAACATGGCTACAAAGCCATTATTTGTAACAGTCAGAATAATCCCGATAAAGAACGGGATTATCTCGAAATGTTAGAAGCTAATCAGGTTGATGGCATTATTTCCAGTAGTCACAACCTCGGCATTGATGACTATGAGAAAGTTTCTGCTCCTATTATTGCCTTTGATCGTAACTTAGCACCCAATATTCCCATCGTCTCTTCTGACAATTTTGAAGGCGGACGAATGGCCGCAAAACTTTTAAAAAAACACGGCTGCCAACATCCCATTATGATCGCTGGAAAAGATAATTCTAATTCTCCGACAGGACTGCGACAATTAGGCTTTAAGTCCGTCTTTGCTCAAGCACCTATTTTTCATCTATCTGGAGAGCTGTCCATCATTCGTAAAGAAATGGAAATAAAAGTAATTCTCCAAAATGAAAAACCTGATGGTATCTTTTTGTCCGATGATATGACAGCTATTTTAACAATGAAAATTGCTAACCAGTTAAACATTACCATTCCCCATGAACTTAAAATTATTGGGTACGATGGAACACACTTTGTTGAGAACTACTATCCTTATCTAACAACTATTAGGCAACCTATTAAAGATATCGCACATCTTTTGGTAGACGTATTGCTAAAGAAAATTGATCACCAAGATACTCCTAAAGATTATATTCTCCCCGTTGGTCTTTTATCAGGAGAAAGTGTTTAG","8.20","3.32","35613","MVAKLTDVAKLAGVSPTTVSRVINRKGYLSEKTITKVQAAMKTLGYKPNNLARSLQGKSAKLIGLIFPNISHIFYSELIEYLEIELFKHGYKAIICNSQNNPDKERDYLEMLEANQVDGIISSSHNLGIDDYEKVSAPIIAFDRNLAPNIPIVSSDNFEGGRMAAKLLKKHGCQHPIMIAGKDNSNSPTGLRQLGFKSVFAQAPIFHLSGELSIIRKEMEIKVILQNEKPDGIFLSDDMTAILTMKIANQLNITIPHELKIIGYDGTHFVENYYPYLTTIRQPIKDIAHLLVDVLLKKIDHQDTPKDYILPVGLLSGESV","1743812","For other 'scr' genes see SMu0094 (scrR); SMu1676 (scrK); SMu1677 (scrA) and SMu1678 (scrB).","sucrose operon repressor","Cytoplasm","This sequence corresponds to the previously published gi1184967 and gi2495406. In addition, residues 1-320 are 66% similar to gi15901558 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1692 (1e-123).","

InterPro
IPR000169
Active_site

Peptidase, cysteine peptidase active site
PS00639	$\"[255-265]F$	THIOL_PROTEASE_HIS

InterPro
IPR000843
Domain

Bacterial regulatory protein, LacI
PR00036	$\"[4-14]T$ $\"[14-24]T$	HTHLACI
PF00356	$\"[3-28]T$	LacI
SM00354	$\"[2-72]T$	HTH_LACI
PS00356	$\"[5-23]T$	HTH_LACI_1
PS50932	$\"[3-57]T$	HTH_LACI_2

InterPro
IPR001761
Domain

Periplasmic binding protein/LacI transcriptional regulator
PF00532	$\"[60-196]T$	Peripla_BP_1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[1-59]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[54-189]T$	G3DSA:3.40.50.2300
SSF53822	$\"[59-314]T$	SSF53822

InterPro
IPR006027
Domain

NusB/RsmB/TIM44
G3DSA:1.10.940.10	$\"[6-138]T$	NusB_RsmB_TIM44
PF01029	$\"[10-141]T$	NusB

InterPro
IPR011605
Family

NusB antitermination factor
TIGR01951	$\"[9-139]T$	nusB

noIPR
unintegrated

unintegrated
SSF48013	$\"[8-138]T$	SSF48013

","BeTs to 11 clades of COG0781COG name: Transcription termination factor NusBFunctional Class: KThe phylogenetic pattern of COG0781 is -----qvcebrhuj--olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000139 (Antitermination protein NusB) with a combined E-value of 4e-26. IPB000139A 9-20 IPB000139B 87-99 IPB000139C 105-137","Residues 60-138 are 49% similar to a (COMPLETE PROTEOME TRANSCRIPTION) protein domain (PD005242) which is seen in Q9CHN4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 17 16:28:58 2006","Mon Jul 17 16:28:58 2006","Mon Jul 17 16:28:58 2006","Wed Apr 10 09:53:09 2002","Wed Mar 6 11:56:34 2002","Wed Mar 6 11:56:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1680 is paralogously related (blast p-value < 1e-3) to SMu0436, a predicted RNA-binding Sun protein; possible rRNA methylase.","Wed Mar 6 12:03:53 2002","Mon Jul 17 16:28:58 2006","pdb1EYVA Chain A, The Crystal Structure Of Nusb From Mycobact... 71 5e-014pdb1EY1A Chain A, Solution Structure Of Escherichia Coli Nusb... 63 2e-011","SMU.1845c","","Residues 10 to 141 (E-value = 8.5e-29) place SMu1680 in the NusB family which is described as NusB family (PF01029)","Wed Mar 6 11:56:34 2002","","","","Carlomagno MS, Nappo A.The antiterminator NusB enhances termination at a sub-optimal Rho site.J Mol Biol. 2001 May 25;309(1):19-28.PMID: 11491288","","Wed Mar 6 12:02:55 2002","1","","","SMU.1845c","852" "SMu1681","1744806","1744417","390","ATGGAAAATGAAATGATTGGCGAAATTGTTATTTCCCCACGTGTACTTGAAGTGATTACAGGTGTTGCGACAACGAAAGTTGAAGGTGTTCATTCGCTTCACAATAAAACAGTGACGGATAGTCTTAGTAAAGTTGCTCACGGTCGAGGTGTTTATCTCAAAACAGAAGAAGACGGAACAGTCAGTGCAGATATCTATGTCTACCTACAATATGGGATCAATGTACCTGCTGTTTCCATGGAAATTCAACGGGCAGTCAAAACAGCCGTTTATGATATGGCTGAAGTGAATCTTTCTGAAGTTAATATTCATGTGGTTGGCATTGTGCCGGAAAAGACACCCAAACCTGATATGAAAAACCTATTTGATGAGGATTTTCTTGATGACTAA","4.50","-9.04","14202","MENEMIGEIVISPRVLEVITGVATTKVEGVHSLHNKTVTDSLSKVAHGRGVYLKTEEDGTVSADIYVYLQYGINVPAVSMEIQRAVKTAVYDMAEVNLSEVNIHVVGIVPEKTPKPDMKNLFDEDFLDD","1744433","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-129 are 75% similar to gi|15675649 from S.pyogenes. Residues 4-129 are 61% similar to gi|15900352 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1694 (3e-56).","

InterPro
IPR005531
Family

Protein of unknown function DUF322
PF03780	$\"[5-109]T$	DUF322

noIPR
unintegrated

unintegrated
PD532004	$\"[7-108]T$	PD532004

","BeTs to 3 clades of COG1302COG name: Uncharacterized BCRFunctional Class: SThe phylogenetic pattern of COG1302 is ------V--B--------in-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 6-108 are 54% similar to a (COMPLETE PROTEOME YBJK STRESS-LIKE) protein domain (PD332055) which is seen in Q9CHN5_LACLA.Residues 4-123 are 27% similar to a (PROTEOME COMPLETE GLS24 YTGH) protein domain (PD012770) which is seen in Q9CEF2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 12:07:26 2002","Wed Mar 6 12:06:42 2002","Wed Mar 6 12:07:26 2002","Tue Oct 8 15:41:12 2002","","Wed Mar 6 12:06:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1681 is paralogously related (blast p-value < 1e-3) to SMu0207, a predicted alkaline-shock protein homolog.","Wed Mar 6 12:07:26 2002","","No significant hits to the NCBI PDB database.","SMU.1846c","","Residues 5 to 109 (E-value = 9.9e-39) place SMu1681 in the DUF322 family which is described as Protein of unknown function (DUF322) (PF03780)","Wed Mar 6 12:06:42 2002","24380207","","","","","","1","","","SMU.1846c","853" "SMu1682","1745409","1744849","561","ATGATTGAAGCAAGTAAGCTTAAGGCTGGTATGACTTTTGAAACAACAGACGGAAAATTAATCAGAGTTCTTGAAGCCAGCCACCATAAACCAGGTAAAGGCAATACAGTTATGCGTATGAAATTGCGTGATGTTCGCACAGGTTCAACCTTTGATACAACTTATCGTCCGGAAGAAAAATTTGAACAAGCTATTATCGAAACACGTCCTGCTCAATACCTTTATCAAATGGATGACACTGCTTATTTTATGGACACCGAAAACTATGAGCAGTATGAAATTCCAATCGTTAACATTGAAAATGAATTAAAATTTATCCTTGAGAATTCAGAAGTTAAAATTCAATTCTATGGTTCAGAGGTTATCGGCGTTACCATACCAACAACTGTTGAATTGGTTGTTACTGATACGCAGCCATCTATCAAAGGGGCTACTGTAACAGGTTCAGGTAAACCAGCGACACTTGAAACAGGTCTTGTTGTCAATGTACCTGACTTTATTGAAGTTGGTCAGAAATTAGTTATTAATACCGCTGAGGGAACCTACGTTTCCCGTGCCTAA","4.70","-7.51","20765","MIEASKLKAGMTFETTDGKLIRVLEASHHKPGKGNTVMRMKLRDVRTGSTFDTTYRPEEKFEQAIIETRPAQYLYQMDDTAYFMDTENYEQYEIPIVNIENELKFILENSEVKIQFYGSEVIGVTIPTTVELVVTDTQPSIKGATVTGSGKPATLETGLVVNVPDFIEVGQKLVINTAEGTYVSRA","1744865","","translation elongation factor P","Cytoplasm","Matches in gapped BLAST to translation elongation factor P sequences. Residues 1-186 are 89% similar to gi15900353 from S.pneumoniae and 87% similar to gi15675650 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1695 (5e-94).","

InterPro
IPR001059
Domain

Translation elongation factor P/YeiP, central
PF01132	$\"[68-122]T$	EFP

InterPro
IPR008991
Domain

Translation protein SH3-like
SSF50104	$\"[1-64]T$	Transl_SH3_like

InterPro
IPR011768
Family

Translation elongation factor P
PIRSF005901	$\"[1-186]T$	EF-P
TIGR00038	$\"[1-186]T$	efp

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[65-128]T$ $\"[129-186]T$	OB_NA_bd_sub

InterPro
IPR013185
Domain

Translation elongation factor, KOW-like
PF08207	$\"[3-61]T$	EFP_N

InterPro
IPR013852
Domain

Translation elongation factor P/YeiP, C-terminal
PS01275	$\"[151-170]T$	EFP

InterPro
IPR014722
Domain

Translation protein SH3-like, subgroup
G3DSA:2.30.30.30	$\"[1-64]T$	Ribosomal_L2

InterPro
IPR015365
Domain

Elongation factor P, C-terminal
PF09285	$\"[130-185]T$	Elong-fact-P_C

noIPR
unintegrated

unintegrated
SSF50249	$\"[65-128]T$ $\"[129-186]T$	Nucleic_acid_OB

","BeTs to 15 clades of COG0231COG name: Translation elongation factor P/translation initiation factor eIF5-aFunctional Class: JThe phylogenetic pattern of COG0231 is amtkYqvcEbrhujgpolINxNumber of proteins in this genome belonging to this COG is 1","***** IPB001059 (Elongation factor P (EF-P)) with a combined E-value of 1.1e-47. IPB001059A 23-62 IPB001059B 142-185","Residues 1-186 are 87% similar to a (FACTOR INITIATION ELONGATION BIOSYNTHESIS) protein domain (PD002832) which is seen in EFP_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 12:10:51 2002","Wed Mar 6 12:08:11 2002","Thu Aug 31 16:53:34 2006","Wed Oct 16 08:09:13 2002","Wed Mar 6 12:08:11 2002","Wed Mar 6 12:08:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1682 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 12:10:51 2002","","No significant hits to the NCBI PDB database.","SMU.1847c","","Residues 1 to 186 (E-value = 2.3e-75) place SMu1682 in the EFP family which is described as Elongation factor P (EF-P) (PF01132)","Wed Mar 6 12:08:11 2002","","","","Abratt VR, Mbewe M, Woods DR.Cloning of an EF-P homologue from Bacteroides fragilis that increases B. fragilis glutamine synthetase activity in Escherichia coli.Mol Gen Genet. 1998 May;258(4):363-72.PMID: 9648740Aoki H, Dekany K, Adams SL, Ganoza MC.The gene encoding the elongation factor P protein is essential for viability and is required for protein synthesis.J Biol Chem. 1997 Dec 19;272(51):32254-9.PMID: 9405429 ","","Wed Mar 6 12:15:49 2002","1","","","SMU.1847c","602" "SMu1683","1745549","1746253","705","ATGAGACAAACGATCTATGAGATAATTGATTCAAAAGACAACGATAGTACTGTTGGAAAGTGTTACAACGCTTTTATGATTTTGACAATCAGCTTTAGTTTACTGCCACTTACTGTTAAAACTGACAGCGAATGGAAATACAATATTGATAACATTACATCCTTGCTTTTTCTTATTGATTATCTTTTAAGATTTTGTACTGCAGATTTTCATCTAAACAAGGGAAAACTGTCATTTTTGTATTATCCTTTTACGCCACTTGCTATTATTGATTTACTCTGCTTATCTCCTTCAGTTTTACTATGGAACAACAGTCTCAAATTATTAAAGATTGTACGTTTTACACGGATGCTGCGACTTTTTAAAATCATTCGCCATTCCAAAAATATTACTATTATTCTTAATGTTTTAAAAAAACAAAAAGATTCTCTAGTTATTGTTGGTATTTTTTCTTTAGGATATATTTTTCTATCGGCTTTAATCATTTTTAATGTAGAACCCAATACATTTCCCAGTTTTTTTGACGCCATTTACTGGGCAACTATATCTTTAACCACGGTGGGATATGGAGATATCTTTGCTGTCTCAACTATCGGTAAAATCATTACTATGTTTTCATCTCTCATTGGTGTTGCTATTGTAGCTCTTCCTGCTGGCATCATTACAGCAGGGTATATGGAAGAAATCCAAAACCATAAAAAATAG","9.80","6.57","26563","MRQTIYEIIDSKDNDSTVGKCYNAFMILTISFSLLPLTVKTDSEWKYNIDNITSLLFLIDYLLRFCTADFHLNKGKLSFLYYPFTPLAIIDLLCLSPSVLLWNNSLKLLKIVRFTRMLRLFKIIRHSKNITIILNVLKKQKDSLVIVGIFSLGYIFLSALIIFNVEPNTFPSFFDAIYWATISLTTVGYGDIFAVSTIGKIITMFSSLIGVAIVALPAGIITAGYMEEIQNHKK","1746263","","hypothetical protein (similar to eukaryotic potassium channel proteins)","Membrane, Cytoplasm","Several weak matches in gapped BLAST to potassium channel proteins from eukaryotes, e.g. residues 2-234 are 28% similar to gi|16758912 from R. norvegicus.SMu1683 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003091
Family

Voltage-dependent potassium channel
PR00169	$\"[13-41]T$ $\"[114-140]T$ $\"[170-192]T$ $\"[199-225]T$	KCHANNEL

InterPro
IPR013099
Domain

Ion transport 2
PF07885	$\"[149-227]T$	Ion_trans_2

noIPR
unintegrated

unintegrated
G3DSA:1.10.287.70	$\"[137-234]T$	G3DSA:1.10.287.70
PTHR11537	$\"[1-234]T$	PTHR11537
PTHR11537:SF14	$\"[1-234]T$	PTHR11537:SF14
SSF81324	$\"[13-230]T$	SSF81324

","BeTs to 11 clades of COG1226COG name: Eukaryotic-type potassium channelsFunctional Class: PThe phylogenetic pattern of COG1226 is AMTKyQvCEbr-uj-------Number of proteins in this genome belonging to this COG is 2","***** PR00169 (Potassium channel signature) with a combined E-value of 4.2e-18. PR00169C 48-71 PR00169E 114-140 PR00169G 170-192 PR00169H 199-225***** PR01333 (Two pore domain K+ channel signature) with a combined E-value of 4e-09. PR01333A 182-210 PR01333B 185-194","Residues 49-163 are 28% similar to a (CHANNEL POTASSIUM IONIC VOLTAGE-GATED TRANSMEMBRANE) protein domain (PD337747) which is seen in CIKB_CANFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:40:46 2002","Wed Mar 6 12:19:36 2002","Tue Oct 8 15:40:46 2002","Tue Oct 8 15:40:46 2002","Wed Mar 6 12:19:36 2002","Wed Mar 6 12:19:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1683 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:40:46 2002","","No significant hits to the NCBI PDB database.","SMU.1848","","Residues 45 to 221 (E-value = 6.1e-21) place SMu1683 in the Ion_trans family which is described as Ion transport protein (PF00520)","Wed Mar 6 12:19:36 2002","24380209","","","","","","1","","","SMU.1848","" "SMu1684","1746753","1746301","453","ATGACGAATAGACTTTCTTGGCAAGATTATTTTATGGCAAATGCAGAGTTGATTTCTAAACGTTCCACCTGCAATCGTGCCTATGTCGGTGCTGTATTGGTTAAAAATAATCGAATTATTGCAACGGGTTACAATGGTGGTGTGGCTGATACAGACAATTGTGATGATGTTGGACATGAAATGGAAGATGGGCACTGTATCCGTACAGTTCACGCCGAAATGAATGCCTTGATTCAATGTGCTAAGGAAGGGATTTCTGCCAATAATACGGAAATCTATGTCACGCATTTTCCTTGCATTAATTGCACTAAGGCTCTCTTACAGGCAGGCGTCAAAAAAATTACCTATAATACAGCTTATCGTATTCATCCCTTTGCTATTGAACTCATGACGCAAAAAGAAGTGGAATACGTACAACATGATGTACCGAGAGTGAAATTAGGTGAAAAGTAA","7.00","0.00","16823","MTNRLSWQDYFMANAELISKRSTCNRAYVGAVLVKNNRIIATGYNGGVADTDNCDDVGHEMEDGHCIRTVHAEMNALIQCAKEGISANNTEIYVTHFPCINCTKALLQAGVKKITYNTAYRIHPFAIELMTQKEVEYVQHDVPRVKLGEK","1746317","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0451 (comF);SMu0452 (comFC); SMu0490 (comC);SMu1782 (comA);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).","deoxycytidylate deaminase; late competence protein","Cytoplasm, Extracellular","Matches in gapped BLAST to late competence proteins. Residues 1-148 are 83% similar to gi15675651 from S.pyogenes. Residues 4-137 are 56% similar to gi15924579 from S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1704 (2e-73).","

InterPro
IPR002125
Domain

CMP/dCMP deaminase, zinc-binding
PF00383	$\"[5-118]T$	dCMP_cyt_deam_1
PS00903	$\"[71-106]?$	CYT_DCMP_DEAMINASES

InterPro
IPR015517
Family

Cytidine deaminase
PTHR11086	$\"[2-148]T$	Cyt_deaminase

noIPR
unintegrated

unintegrated
G3DSA:3.40.140.10	$\"[6-146]T$	G3DSA:3.40.140.10
PTHR11086:SF2	$\"[2-148]T$	PTHR11086:SF2
SSF53927	$\"[5-139]T$	SSF53927

","BeTs to 6 clades of COG2131COG name: Deoxycytidylate deaminaseFunctional Class: FThe phylogenetic pattern of COG2131 is a--ky-v--b-------l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 21-118 are 58% similar to a (DEAMINASE COMPLETE PROTEOME REDUCTASE) protein domain (PD001793) which is seen in Q9KD83_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Aug 18 15:59:55 2006","Fri Aug 18 15:59:55 2006","Fri Aug 18 15:49:48 2006","Thu Apr 4 10:14:22 2002","","Wed Mar 6 12:20:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1684 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 12:24:17 2002","","No significant hits to the NCBI PDB database.","SMU.1849c","","Residues 6 to 118 (E-value = 4.1e-35) place SMu1684 in the dCMP_cyt_deam family which is described as Cytidine and deoxycytidylate deaminase zinc-binding region (PF00383)","Wed Mar 6 12:20:52 2002","","","","Pestova EV, Morrison DA.Isolation and characterization of three Streptococcus pneumoniae transformation-specific loci by use of a lacZ reporter insertion vector.J Bacteriol. 1998 May;180(10):2701-10.PMID: 9573156 Inamine GS, Dubnau D.ComEA, a Bacillus subtilis integral membrane protein required for genetic transformation, is needed for both DNA binding and transport.J Bacteriol. 1995 Jun;177(11):3045-51.PMID: 7768800","","Wed Mar 6 12:28:43 2002","1","","","SMU.1849c","720" "SMu1685","1747987","1746923","1065","ATGAAAAATAGATTGATAACATTTGAGGAAAAGTTATCTCAATCGCCAGCTGAAGCTATATTGGTAACTGGCCAAAAAAACGTTTATTATCTAACAGGGTTTTGGGGAACAGCAGGAACAGTTTTTATCAGTAAAAATCGCCGTCTTTTCCTAACCGATGCTCGCTATAGTTTGCTTGCTCGGCAAACCATCACAGACTTTGATATTATCGAAACACGTTCGGCACTTGCAGAAATTGTTAAAATAATCAAAGCTGATAAGCTTTCAGTGATTGGCTTTGACAGTGCTATTACTTATTCTTATTATCAAGAATTGGCAGCGACTTTTGCGGATTATCGTTTACTTGCTCTGACGAATTTTGTAGAAGAGTTACGCATGATTAAGGATACTGATGAAATTGAAGCTATTCGTCGTGCCTGTCAAATTTCTGATCGTGCTTTTGCAGATGTCTTAGATTTTATCAAACCGGGGCAAACGTCTGAGTTAGATGTGGCTAATTTTTTAGATTTTCGTATGCGAAAATATGGTGCAAGCGGCCTATCCTTTGAAACTATTGTTGCATCAGGTTACCGTTCTGCTATTCCTCATGGAGTGGCCGGTGATAAAGTGATTCAGTTGGGCGAAATGTTGACCATGGACTTTGGCTGTTATTATAACCACTATGTCAGTGATATGACACGTACTATCCATATTGGTGTTCCGACTGATGAGGAACGCACTATTTATGATATTGTCCTGAATTCTAATCGTGCTTTAATTGATATACTTAGGCCCAAAATGACACGTCGTGATTATGATAAGGCTGCGCGTGATGTGATTGCAGCAGCAGGTTATGGACAGGCTTTTACGCATGGCATCGGTCATGGTATTGGTCTGGATATTCACGAAATACCTTATTTTGGTAACGTTGAAGGCAGAATTGAATCTGGTATGGTTATCACAGATGAGCCTGGTATTTATCTAGATGGCAAGTATGGCGTTCGCATTGAAGATGATCTCCTTGTAACTAAGGATGGTTGTGAAGTGTTGACCCTAGCTCCTAAAGAGTTAATTATTTTAAAGTAG","5.10","-8.67","39687","MKNRLITFEEKLSQSPAEAILVTGQKNVYYLTGFWGTAGTVFISKNRRLFLTDARYSLLARQTITDFDIIETRSALAEIVKIIKADKLSVIGFDSAITYSYYQELAATFADYRLLALTNFVEELRMIKDTDEIEAIRRACQISDRAFADVLDFIKPGQTSELDVANFLDFRMRKYGASGLSFETIVASGYRSAIPHGVAGDKVIQLGEMLTMDFGCYYNHYVSDMTRTIHIGVPTDEERTIYDIVLNSNRALIDILRPKMTRRDYDKAARDVIAAAGYGQAFTHGIGHGIGLDIHEIPYFGNVEGRIESGMVITDEPGIYLDGKYGVRIEDDLLVTKDGCEVLTLAPKELIILK","1746939","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1415 (pepM) and SMu1447 (pepQ). ","aminopeptidase P (XAA-Pro aminopeptidase)","Cytoplasm, Extracellular","Matches in gapped BLAST to aminopeptidase P sequences. Residues 1-353 are 65% similar to gi15675652 from S.pyogenes and 53% similar to gi15902216 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0706 (9e-41).","

InterPro
IPR000587
Domain

Creatinase
PF01321	$\"[18-127]T$	Creatinase_N

InterPro
IPR000994
Domain

Peptidase M24, catalytic core
G3DSA:3.90.230.10	$\"[126-349]T$	Peptidase_M24_cat_core
PTHR10804	$\"[173-344]T$	Peptidase_M24_cat_core
PF00557	$\"[134-345]T$	Peptidase_M24

InterPro
IPR001131
Domain

Peptidase M24B, X-Pro dipeptidase, cataltyic core
PS00491	$\"[284-296]T$	PROLINE_PEPTIDASE

noIPR
unintegrated

unintegrated
G3DSA:3.40.350.10	$\"[1-125]T$	G3DSA:3.40.350.10
PTHR10804:SF16	$\"[173-344]T$	PTHR10804:SF16
SSF53092	$\"[1-126]T$	SSF53092
SSF55920	$\"[126-353]T$	SSF55920

","BeTs to 16 clades of COG0006COG name: Xaa-Pro aminopeptidaseFunctional Class: EThe phylogenetic pattern of COG0006 is amtKYqvcEBRhujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** IPB001131 (Proline dipeptidase) with a combined E-value of 3.1e-54. IPB001131A 176-196 IPB001131B 208-229 IPB001131C 284-296 IPB001131D 307-320 IPB001131E 326-344***** IPB002467 (Methionine aminopeptidase, subfamily 1) with a combined E-value of 2.3e-09. IPB002467C 204-232 IPB002467F 314-344 IPB002467D 278-303 IPB002467E 307-319","Residues 11-102 are 40% similar to a (AMINOPEPTIDASE XAA-PRO HYDROLASE PROTEOME) protein domain (PD391003) which is seen in Q9CHN7_LACLA.Residues 118-196 are 37% similar to a (DIPEPTIDASE AMINOPEPTIDASE HYDROLASE XAA-PRO PROTEOME) protein domain (PD335744) which is seen in O67493_AQUAE.Residues 160-319 are 41% similar to a (AMINOPEPTIDASE METHIONINE HYDROLASE MAP) protein domain (PD000555) which is seen in YQHT_BACSU.Residues 124-203 are 62% similar to a (AMINOPEPTIDASE DIPEPTIDASE COMPLETE) protein domain (PD004954) which is seen in O08316_BBBBB.Residues 304-351 are 77% similar to a (AMINOPEPTIDASE COMPLETE PROTEOME DIPEPTIDASE HYDROLASE) protein domain (PD000896) which is seen in O08316_BBBBB.Residues 154-196 are 55% similar to a (COMPLETE PROTEOME AMINOPEPTIDASE) protein domain (PD383450) which is seen in Q9WXP9_THEMA.Residues 204-283 are 53% similar to a (AMINOPEPTIDASE DIPEPTIDASE COMPLETE PROTEOME HYDROLASE) protein domain (PD289122) which is seen in Q9CHN7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 11:46:38 2006","Wed Mar 6 12:33:08 2002","Thu Sep 28 11:46:38 2006","Thu Apr 4 11:14:27 2002","Wed Mar 6 12:33:08 2002","Wed Mar 6 12:33:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1685 is paralogously related (blast p-value < 1e-3) to SMu1447, a predicted dipeptidase, and to SMu1415, a predicted methionine aminopeptidase A.","Wed Mar 6 12:34:53 2002","Thu Sep 28 11:46:38 2006","pdb1JAW Aminopeptidase P From E. Coli Low Ph Form 96 7e-021pdb1AZ9 Aminopeptidase P From E. Coli 96 7e-021pdb1A16 Aminopeptidase P From E. Coli With The Inhibitor P... 96 7e-021","SMU.1850c","","Residues 283 to 344 (E-value = 1.7e-14) place SMu1685 in the Peptidase_M24 family which is described as metallopeptidase family M24 (PF00557)","Wed Mar 6 12:33:08 2002","","","","Matos J, Nardi M, Kumura H, Monnet V.Genetic characterization of pepP, which encodes an aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl aminopeptidase.Appl Environ Microbiol. 1998 Nov;64(11):4591-5.PMID: 9797327Hanna MN, Ferguson RJ, Li YH, Cvitkovitch DG.uvrA is an acid-inducible gene involved in the adaptive response to low pH in Streptococcus mutans.J Bacteriol. 2001 Oct;183(20):5964-73.PMID: 11566996 ","Thu Sep 28 11:46:38 2006","Wed Mar 6 12:50:07 2002","1","","","SMU.1850c","" "SMu1686","1750808","1747977","2832","ATGCAAGATAAATTAATTATTCGTGGAGCGCGTGCTCATAACTTAAAAAATATAGATGTGGAAATTCCGCGTGATAAGTTGATTGTCATGACGGGCTTATCGGGTTCAGGAAAGTCCAGTCTGGCTTTTGATACCATTTACGCCGAAGGGCAACGCCGTTATGTTGAGAGTTTATCGGCTTATGCTAGACAGTTTTTAGGAAATATGGATAAGCCTGATGTTGATTCGATTGATGGTCTTAGCCCTGCTATTTCCATTGACCAAAAGACAACCAGTAAAAATCCACGTTCTACTGTTGGTACAGTTACAGAGATTAATGATTATCTCCGATTATTATATGCACGCGTTGGTATTCCTTATTGTAAAAATGGTCATGGTGCTATCACGGCTTCTTCAGTAGAGCAGATTGTTGATCAAGTTTTGATCTTGCCTGAGCGGACACGAATGCAGATTTTGGCACCTGTTGTTCGGCGGAAAAAAGGTCAACATAAGGCAGTATTTGATCGCATTCAAAAAGATGGCTATGTTCGTGTGCGTATAGATGGCGACATTATGGATGTAGCAGAAGTTCCTGAACTTTCAAAAAATAAAATGCACAACATTGAAGTGGTTGTTGATCGTCTCGTGCAAAAGGATGGTATTAGAGGACGTTTGTTTGATTCCATTGAAGCAGCTTTGCATTTGGGAGATGGTTATGTCATCATTGATACTATGGATGATCATGAATTGATTTTCTCAGAACACTATTCTTGTCCTGTTTGTGGTTTTACTGTTCCAGAATTGGAACCGCGTCTCTTTTCTTTTAATGCACCCTTTGGTTCTTGTCCTACCTGTGATGGTTTAGGGATTAAATTAGAAGTCGATTTGGACTTGGTTATTCCAGATGAGAATAAGACTTTGAGAGAGGGAACGCTGGCTCCTTGGAATCCTATTTCTTCAAACTATTATCCGCAGCTATTAGAGCAGGCTATGAATGCTTTTGGTGTAGATATGGATAAACCTTGGAAAGATTTATCAGATGAGGATAAAAAACTCGTCTTACATGGTTCAGGTGACACAGCATTTCATTTTCATTATCAAAATGATTTTGGCGGTGTCAGGGATATTGATATTCCTTTTGAAGGCATTATTAGCAATATTAGCCGCCGTTATCATGAAACTAATAGTGATTTCACACGTAATGTCATGCGCAGCTATATGAATGAGCTGCCTTGTGCAACCTGTCATGGTTATCGACTCAATGATCAAGCTCTTAGTGTACGGGTTGGCGGAAAAGAAGGCCTAAATATTGGTCAGGTATCTGAGCTATCCATTGCGGATCACTTGAGTTTGCTGACTCATTTGGAACTGTCAGAAAATGAAAAAACCATTGCAACACCCATTGTCAAGGAAATTAAGGATCGTCTGACTTTCCTTAATAATGTGGGTCTTAATTATTTGACTTTATCACGCTCAGCAGGAACGCTATCAGGAGGTGAAAGCCAACGCATTCGTCTAGCAACTCAGATTGGTTCTAATTTAAGCGGTGTACTTTATATTTTGGATGAACCTTCCATTGGTTTACATCAAAGAGATAACGACCGCCTTATTTCCAGTCTTAAGAAAATGCGAGATTTGGGGAATACTTTGATTGTTGTCGAACATGATGAAGATACCATGATGGCAGCTGATTGGCTGGTTGATGTTGGACCGGGAGCAGGTGCTTTAGGTGGTGAAATTGTTGCCTCAGGCACCCCAAGGCAAGTTGCTAAAAATAAAAAGTCTATTACTGGACAGTATTTATCTGGTAAGAAAAAAATTCCTGTACCTTTGGATCGTCGTAAAGGGAGTGGCCGTTTCATTGAAATCAAAGGAGCAGCAGAAAACAATCTGCAAAACATTAATGTTAAATTTCCTCTTGGAAAATTTATTGCCGTTACAGGTGTTTCGGGTTCTGGTAAATCAACACTGGTTAATAGTATTTTAAAAAAAGTCATTGCTCAAAAACTCAATCGTAATTCTGAAAAGCCAGGCAAATACAAGTCTATTTCAGGAATTGAACATATTGATCGTTTAATTGACATTGATCAAAGCCCAATTGGCCGTACACCAAGATCCAATCCTGCCACCTATACAGGTGTCTTTGATGATATTCGTGACCTTTTTGCTCAAACCAATGAAGCTAAAATTCGCGGTTACAAGAAGGGACGTTTTTCTTTCAATGTTAAAGGCGGACGCTGCGAAGCCTGCTCAGGTGATGGCATTATCAAAATTGAAATGCACTTTTTGCCAGATGTTTATGTGCCTTGTGAAGTCTGTCATGGAACGCGTTATAATAGTGAGACTTTGGAAGTTCATTACAAGGACAAAAATATTGCAGAAATTCTTAATATGACAGTCAATGACGCAGCAGAATTTTTTGCACCGATTCCTAAAATTGCTCGCAAGATTCGAACCATTAAGGATGTTGGTCTGGGTTATGTGACTCTTGGACAGCCAGCGACCACTTTATCAGGTGGGGAAGCGCAGCGCATGAAGTTGGCTTCTGAACTGCATAAACGCTCAACGGGAAAGAGTTTTTATATTCTTGATGAGCCTACAACTGGTCTCCATACAGATGATATTGCTAGACTTCTTAAAGTCTTAGAGCGCTTTGTTGATGATGGCAATACCGTGCTTGTCATTGAGCATAATTTGGACGTTATTAAAACAGCTGACCATATTATTGACTTGGGACCGGAAGGCGGTGTTGGTGGTGGTCAAGTCATAGCGACTGGGACACCAGAACAAGTAGCTGAGATGACGGAAAGCTATACAGGACAGTATTTGAAGGGAAGACTAAATGAAAAATAG","6.90","-1.65","104115","MQDKLIIRGARAHNLKNIDVEIPRDKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGNMDKPDVDSIDGLSPAISIDQKTTSKNPRSTVGTVTEINDYLRLLYARVGIPYCKNGHGAITASSVEQIVDQVLILPERTRMQILAPVVRRKKGQHKAVFDRIQKDGYVRVRIDGDIMDVAEVPELSKNKMHNIEVVVDRLVQKDGIRGRLFDSIEAALHLGDGYVIIDTMDDHELIFSEHYSCPVCGFTVPELEPRLFSFNAPFGSCPTCDGLGIKLEVDLDLVIPDENKTLREGTLAPWNPISSNYYPQLLEQAMNAFGVDMDKPWKDLSDEDKKLVLHGSGDTAFHFHYQNDFGGVRDIDIPFEGIISNISRRYHETNSDFTRNVMRSYMNELPCATCHGYRLNDQALSVRVGGKEGLNIGQVSELSIADHLSLLTHLELSENEKTIATPIVKEIKDRLTFLNNVGLNYLTLSRSAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLISSLKKMRDLGNTLIVVEHDEDTMMAADWLVDVGPGAGALGGEIVASGTPRQVAKNKKSITGQYLSGKKKIPVPLDRRKGSGRFIEIKGAAENNLQNINVKFPLGKFIAVTGVSGSGKSTLVNSILKKVIAQKLNRNSEKPGKYKSISGIEHIDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNEAKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVPCEVCHGTRYNSETLEVHYKDKNIAEILNMTVNDAAEFFAPIPKIARKIRTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYILDEPTTGLHTDDIARLLKVLERFVDDGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGQVIATGTPEQVAEMTESYTGQYLKGRLNEK","1747993","For other 'uvr' genes see SMu0734 (uvrB) and SMu1136 (uvrC). For the subunit B sequence (uvrB), see SMu0734.For the subunit C sequence (uvrC) see SMu1136.","excinuclease ABC subunit A","Cytoplasm","This sequence corresponds to the previously published gi1661191 in GenBank. Residues 469-604 are identical to residues 1-136 of gi1661191. Also, residues 1-942 are 85% similar to gi15675653 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1709 (0.0).","

InterPro
IPR003439
Domain

ABC transporter related
PF00005	$\"[634-908]T$	ABC_tran
PS00211	$\"[489-503]T$ $\"[830-844]T$	ABC_TRANSPORTER_1
PS50893	$\"[605-937]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[24-260]T$ $\"[633-908]T$	AAA

InterPro
IPR004602
Family

Excinuclease ABC, A subunit
TIGR00630	$\"[4-925]T$	uvra

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[438-586]T$ $\"[623-935]T$	G3DSA:3.40.50.300
PTHR19222	$\"[784-927]T$	PTHR19222
SSF52540	$\"[7-571]T$ $\"[604-934]T$	SSF52540

","BeTs to 13 clades of COG0178COG name: Excinuclease ATPase subunitFunctional Class: LThe phylogenetic pattern of COG0178 is --t--qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 2.4e-13. IPB001140A 623-669 IPB001140C 884-913 IPB001140A 14-60 IPB001140C 542-571","Residues 600-651 are 62% similar to a (ABC EXCINUCLEASE ATP-BINDING SUBUNIT) protein domain (PD002065) which is seen in UVRA_LACLA.Residues 243-360 are 60% similar to a (ABC EXCINUCLEASE SUBUNIT ATP-BINDING) protein domain (PD003717) which is seen in Q9K6Y0_BACHD.Residues 133-242 are 69% similar to a (EXCINUCLEASE ABC SUBUNIT ATP-BINDING) protein domain (PD003919) which is seen in UVRA_LACLA.Residues 343-404 are 41% similar to a (ABC SUBUNIT EXCINUCLEASE ATP-BINDING) protein domain (PD363446) which is seen in Q9KUW5_VIBCH.Residues 882-936 are 45% similar to a (ABC EXCINUCLEASE ATP-BINDING SUBUNIT) protein domain (PD001721) which is seen in Q9HWG0_PSEAE.Residues 709-877 are 59% similar to a (ABC EXCINUCLEASE ATP-BINDING SUBUNIT) protein domain (PD001646) which is seen in UVRA_BACSU.Residues 652-708 are 82% similar to a (EXCINUCLEASE ABC SUBUNIT ATP-BINDING) protein domain (PD003881) which is seen in UVRA_LACLA.Residues 600-651 are 64% similar to a (EXCINUCLEASE ABC ATP-BINDING SUBUNIT) protein domain (PD407780) which is seen in UVRA_MYCGE.Residues 361-400 are 55% similar to a (A PROTEOME ATP-BINDING SUBUNIT) protein domain (PD376282) which is seen in Q9K6Y0_BACHD.Residues 829-875 are 48% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9X7M5_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 16 08:34:13 2006","Wed Aug 16 08:34:13 2006","Wed Aug 16 08:34:13 2006","Mon Apr 1 16:18:20 2002","Wed Mar 6 12:41:12 2002","Mon Oct 28 01:25:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1686 is paralogously related (blast p-value < 1e-3) to SMu1064, SMu0884, SMu0731, SMu0164, SMu0218, SMu1949, SMu1751, SMu1068, SMu0849, SMu0418, SMu1023, SMu1001, SMu1950, SMu1517, SMu0390, SMu1210, SMu1065, SMu0837, SMu0517, SMu1518, SMu0907, SMu1246, SMu1231, SMu0024, SMu1710, SMu0836, SMu0824, SMu0805, SMu0786, SMu1757, SMu1288, SMu0916, SMu0596, SMu1811, SMu0950, SMu1428, SMu1410, SMu1380, SMu1003, and SMu0258, all ABC related elements.","Wed Mar 6 12:49:42 2002","","No significant hits to the NCBI PDB database.","SMU.1851c","","Residues 25 to 565 (E-value = 4.4e-06) place SMu1686 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 634 to 905 (E-value = 7.3e-30) place SMu1686 in the ABC_tran family which is described as ABC transporter (PF00005)","Wed Aug 16 08:34:13 2006","","","Hanna MN, Ferguson RJ, Li YH, Cvitkovitch DG.uvrA is an acid-inducible gene involved in the adaptive response to low pH in Streptococcus mutans.J Bacteriol. 2001 Oct;183(20):5964-73.PMID: 11566996 ","Smith BT, Grossman AD, Walker GC.Localization of UvrA and effect of DNA damage on the chromosome of Bacillus subtilis.J Bacteriol. 2002 Jan;184(2):488-93.PMID: 11751826Goosen N, Moolenaar GF.Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair.Res Microbiol. 2001 Apr-May;152(3-4):401-9. Review.PMID: 11421287","Mon Oct 28 01:25:45 2002","Wed Mar 6 12:51:34 2002","1","","","SMU.1851c","175" "SMu1687","1751479","1752423","945","ATGAAGCAAATGTTTCTTTCAACAGCAACCGAATTTAAAGAAATCGAAACATTCGAGCCAGGTGCTTGGATTAATTTGGTCAATCCCTCCCAGGAAGAGTCTTTACAGATTGCTGAAAGGTTCAATATTGATATCACAGACTTAAGAGCACCACTTGATGTTGAAGAAACCTCACGTGTTTCTGTTGAGGATGATTATACTCTCATTATTGTTGACGTTCCCACACCAGAAGAACGCAACAGCAGAAGTTACTTTATTACAATTCCTCTTGGTATTATTGTCACAGAAACAGCTGTTATTACGACTTGTTTAGAATCTTTGACTCTCTTTGACAATTTCTGGAGCCATCGTATCCGTAATTTTTATACTTTCATGAAGACACGTTTCGTTTTCCAGCTCCTCTATCGCAATGCCGGACTTTACCTAACTGCCCTGCGTTCTATTGATCGTCAAAGTGATAAAATTGAAGCTCAGCTGGAAAAAGCAACACGCAATGAACAGCTAATTGACATGATGGAATTAGAAAAATCAATTGTCTACCTCAGAGCCTCTCTAAAACTTAATGAACGAATCGTTAAAAAGCTCTCCAGCAATACATCCAGTCTCAAAAAATATGTGGAAGATGAAGATTTGCTGGAAGATACTTTAATTGAGACACAACAGGCCATTGAGATGGCAGGTATCTATGAAAATGTCCTTAATGTTATGACTGAAACTTCTGCTTCAATTATTTCTAACAACCAAAATACTATAATGAAAACTTTAGCTCTGATGACAATGGCTTTAGATATACCAACTGTCATTTTCTCTGCTTATGGTATGAATTTTCAAAATAACTGGTTACCACTAAATGGATTGAATCATGCTTTCTGGTATATCGTCTTAATTGCAGCAGCAATGAGTGCTATTGTCGTTATTTATTTCATTCGCAAAAAATGGTTTTAA","4.60","-11.54","36260","MKQMFLSTATEFKEIETFEPGAWINLVNPSQEESLQIAERFNIDITDLRAPLDVEETSRVSVEDDYTLIIVDVPTPEERNSRSYFITIPLGIIVTETAVITTCLESLTLFDNFWSHRIRNFYTFMKTRFVFQLLYRNAGLYLTALRSIDRQSDKIEAQLEKATRNEQLIDMMELEKSIVYLRASLKLNERIVKKLSSNTSSLKKYVEDEDLLEDTLIETQQAIEMAGIYENVLNVMTETSASIISNNQNTIMKTLALMTMALDIPTVIFSAYGMNFQNNWLPLNGLNHAFWYIVLIAAAMSAIVVIYFIRKKWF","1752433","","cation transporter, CorA family","Membrane, Cytoplasm","Matches in gapped BLAST to divalent cation transport proteins. Residues 1-314 are 77% similar to gi15675654 from S.pyogenes and 64% similar to gi15900122 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1711 (1e-138).","

InterPro
IPR002523
Family

Mg2+ transporter protein, CorA-like
PTHR21535:SF1	$\"[7-314]T$	Mg2+_transptCorA
PF01544	$\"[21-314]T$	CorA

noIPR
unintegrated

unintegrated
PTHR21535	$\"[7-314]T$	PTHR21535

","BeTs to 10 clades of COG0598COG name: Mg and Co transportersFunctional Class: PThe phylogenetic pattern of COG0598 is am-kYqvCEBrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB002523 (CorA-like Mg2+ transporter protein) with a combined E-value of 3.2e-07. IPB002523A 23-33 IPB002523D 249-281","Residues 145-310 are 34% similar to a (COMPLETE PROTEOME TRANSPORT MAGNESIUM COBALT) protein domain (PD003039) which is seen in Q9RRM5_DEIRA.Residues 21-142 are 32% similar to a (PROTEOME COMPLETE TRANSPORT PROTEIN) protein domain (PD223080) which is seen in Q9RRM5_DEIRA.Residues 37-228 are 28% similar to a (PROTEOME COMPLETE MEMBRANE ORFA) protein domain (PD038170) which is seen in Q9CFJ3_LACLA.Residues 23-160 are 28% similar to a (MAGNESIUM COBALT TRANSPORT COMPLETE) protein domain (PD208658) which is seen in Q58439_METJA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 16 08:02:58 2002","Tue Sep 19 10:21:17 2006","Tue Sep 19 10:21:17 2006","Wed Oct 16 08:02:58 2002","Wed Mar 6 13:07:57 2002","Wed Mar 6 13:07:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1687 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 16 08:02:58 2002","","No significant hits to the NCBI PDB database.","SMU.1852","","Residues 21 to 314 (E-value = 9.1e-08) place SMu1687 in the CorA family which is described as CorA-like Mg2+ transporter protein (PF01544)","Wed Mar 6 13:07:57 2002","24380213","","","","","","1","","","SMU.1852","464" "SMu1688","1752705","1753367","663","ATGGATGTACAAAATCTTACTAAAAAAAATCAAGAATTCATCAATATTGTAACACATCAATTGCTCCAATCAGGCAAATCCGATGAAGATATTCAAACTATTCTCGCCAAGACTTTACCTGAAATTATCGAAAAACAAAAGCAAGGAATCCCTGCACGTTCTTTTTTGGGTGCACCAACTGCTTGGGCAGCTCAATTTATTGAAACAGAACAAAACAAGTCAACAGCTTCTGCTCCTAAAAATACAAATCCCTGGCTTATGTGGCTAGATACTTCCCTCTTCTTCCTTGCTGTTGTGACCTTAATAACAGGATTTTTAAATTTTTTTAGCAAACAAGCACCTACCTACGGGATTGTGACACTTACCTTTCTTGGCTTTGGTGGCGGTGCTATCATGTTTTTAACTTATCACTTTTTCTATCGCTACTCAGGAATGCCTAAAAATGAACGTCCTAGTTTTATCAAATCATTTGGGATCTTAGCATTCTTCATGATTTTTTGGATGTTTCTTTATGCAGCAACAGGCTTCTTACCAGCTTTTCTCAATCCCAAAGTTCCAGGCTTCGTCTTGCTTGTTATTTGTGCCCTCGCTTTTGGTATTCGTTATCTGCTTAAGAAAAAATATAATATTGAAAATGCTTTGGCTCCTCAACAAAGAAAATAA","10.50","9.42","24907","MDVQNLTKKNQEFINIVTHQLLQSGKSDEDIQTILAKTLPEIIEKQKQGIPARSFLGAPTAWAAQFIETEQNKSTASAPKNTNPWLMWLDTSLFFLAVVTLITGFLNFFSKQAPTYGIVTLTFLGFGGGAIMFLTYHFFYRYSGMPKNERPSFIKSFGILAFFMIFWMFLYAATGFLPAFLNPKVPGFVLLVICALAFGIRYLLKKKYNIENALAPQQRK","1753377","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-216 are 50% similar to gi|15675655 from S.pyogenes. Residues 1-219 are 40% similar to gi|15900121 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1710 (2e-68).","

InterPro
IPR009214
Family

Membrane protein of unknown function UCP033111
PIRSF033111	$\"[1-220]T$	UCP033111
PF06570	$\"[1-213]T$	DUF1129

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-220 are 38% similar to a (PROTEOME COMPLETE) protein domain (PD400543) which is seen in Q9CJ13_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:39:55 2002","Wed Mar 6 13:10:35 2002","Tue Oct 8 15:39:55 2002","Wed Mar 6 13:10:35 2002","","Wed Mar 6 13:10:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1688 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:39:55 2002","","No significant hits to the NCBI PDB database.","SMU.1853","","Residues 1 to 213 (E-value = 1.1e-149) place SMu1688 in the DUF1129 family which is described as Protein of unknown function (DUF1129) (PF06570)","Wed Mar 6 13:10:35 2002","24380214","","","","","","1","","","SMU.1853","854" "SMu1689","1753461","1753862","402","ATGGAGACAAGATACATTTTTGATGACAAAGTGGCGCCCGGTGTTATGGAGATTCACTTAAATCCTAAACATCAGTCAGTAGAGGTCTTTTTAGAAAAGGAAATTTTCTTTTTAAATATTAGAGATATTCTCTTTATTGAAATCAACAATCGGAAAACTTATGTTCATACTAATGATAAAGTTTACAAAAGCCATTTGCTTCTGCGCGATTTCAAAGAAATTTTACCTGATTATTTTCAGCAAATTGGCAAGAGTCAGATTGCCAATAGCCTTGAAATTTCTGCCATCAATAAGTCTTTCTCCTCTACCCCCAAAATTAGTTTTAGACATTCATCCAAAACAACTTGGGTATCTCGTAAATACTACAAAGAATTACTTATGAAAAAAAGGAGTTTACTATGA","10.40","8.19","15841","METRYIFDDKVAPGVMEIHLNPKHQSVEVFLEKEIFFLNIRDILFIEINNRKTYVHTNDKVYKSHLLLRDFKEILPDYFQQIGKSQIANSLEISAINKSFSSTPKISFRHSSKTTWVSRKYYKELLMKKRSLL","1753872","","high density responsive regulator, HdrR","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins. Residues 36-132 are 38% similar to residues 52-148 of gi15901739 from S.pneumoniae. Residues 23-125 are 24% similar to gi15925353 from S.aureus.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1016 (3e-04).","

InterPro
IPR007492
Domain

LytTr DNA-binding region
PF04397	$\"[33-130]T$	LytTR
PS50930	$\"[27-133]T$	HTH_LYTTR

InterPro
IPR012360
Family

LytTR_ LMO transcriptional regulator, putative
PIRSF031486	$\"[1-133]T$	LMO_LytTR

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[10-32]?$ $\"[38-58]?$ $\"[73-93]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-24]?$	signal-peptide
tmhmm	$\"[27-47]?$ $\"[62-82]?$ $\"[88-106]?$ $\"[116-136]?$ $\"[155-175]?$ $\"[185-203]?$ $\"[217-237]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-229 are 35% similar to a (ASSEMBLY FIMC SEROGROUP FIMBRIAL) protein domain (PD038706) which is seen in Q9CFU4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 16:39:47 2002","Wed Mar 6 16:38:39 2002","Wed Mar 6 16:39:47 2002","Wed Mar 6 16:38:39 2002","","Wed Mar 6 16:38:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1691 is paralogously related (blast p-value < 1e-3) to SMu0600, a conserved hypothetical.","Wed Mar 6 16:39:47 2002","","No significant hits to the NCBI PDB database.","SMU.1856c","","No significant hits to the Pfam 11.0 database","Wed Mar 6 16:38:39 2002","24380217","","","","","","1","","","SMU.1856c","" "SMu1692","1755830","1755591","240","ATGGCTCAACAACGTCGTGGCGGATTCAAACGCCGTAAAAAAGTTGATTATATCGCAGCAAATAAAATTGAATATGTTGATTACAAAGATACTGAATTGCTTAGTCGTTTTGTTTCAGAACGTGGAAAGATTCTTCCACGCCGTGTGACAGGGACTTCGGCTAAGAATCAACGTAAGGTAACAACAGCTATCAAACGTGCTCGCGTAATGGCACTTATGCCTTTTGTAAATGAAGATTAA","11.50","11.98","9187","MAQQRRGGFKRRKKVDYIAANKIEYVDYKDTELLSRFVSERGKILPRRVTGTSAKNQRKVTTAIKRARVMALMPFVNED","1755607","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1841 (rps10);SMu1838 (rps19); SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA) and SMu1694 (rpsF).For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1828 (rs8); SMu1819 (rs13) SMu1819 (rs13); SMu1819 (rs13); SMu1818 (rs11) and SMu1694 (rs6). ","30S ribosomal protein S18","Cytoplasm, Extracellular","Matches in gapped BLAST to 30S ribosomal S18 sequences. Residues 1-79 are 87% similar to gi|15901383 from S.pneumoniae and 84% similar to gi|15675656 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1712 (5e-33).","

InterPro
IPR001648
Family

Ribosomal protein S18
PD002239	$\"[25-78]T$	RS18_STRPN_Q97PR3;
PR00974	$\"[33-43]T$ $\"[43-50]T$ $\"[51-65]T$ $\"[65-75]T$	RIBOSOMALS18
G3DSA:4.10.640.10	$\"[4-78]T$	no description
PTHR13479	$\"[10-79]T$	30S RIBOSOMAL PROTEIN S18
PF01084	$\"[20-73]T$	Ribosomal_S18
TIGR00165	$\"[9-78]T$	S18: ribosomal protein S18
PS00057	$\"[26-49]T$	RIBOSOMAL_S18

noIPR
unintegrated

unintegrated
PTHR13479:SF16	$\"[10-79]T$	30S RIBOSOMAL PROTEIN S18

","BeTs to 13 clades of COG0238COG name: Ribosomal protein S18Functional Class: JThe phylogenetic pattern of COG0238 is ----yqvcebRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001648 (Ribosomal protein S18) with a combined E-value of 6.1e-33. IPB001648 33-75","Residues 20-73 are 88% similar to a (RIBOSOMAL 30S CHLOROPLAST RNA-BINDING REPEAT S18-1 BS21) protein domain (PD002239) which is seen in RS18_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 14:07:33 2002","Wed Mar 6 16:44:22 2002","Wed Mar 6 16:50:47 2002","Thu Apr 4 14:56:14 2002","Wed Mar 6 16:44:22 2002","Wed Mar 6 16:44:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1692 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 16:50:47 2002","Wed Mar 6 16:44:22 2002","pdb|1FKA|R Chain R, Structure Of Functionally Activated Small R... 64 3e-012pdb|1FKA|R Chain R, Structure Of Functionally Activated Small R... 94 3e-021","SMU.1858c","","Residues 20 to 73 (E-value = 5.5e-34) place SMu1692 in the Ribosomal_S18 family which is described as Ribosomal protein S18 (PF01084)","Wed Mar 6 16:44:22 2002","","","","","","","1","","","SMU.1858c","971" "SMu1693","1756353","1755859","495","ATGATTAATAATGTAGTACTAGTTGGTCGCATGACTCGTGATGCTGAGCTCCGTTACACCCCAAGTAATCAAGCTGTGGCAACTTTTACGCTTGCGGTTAACCGTAATTTTAAAAATCAAAATGGTGAACGTGAAGCTGATTTCATTAATATCGTGATTTGGCGTCAGCAAGCTGAAAATTTAGCTAACTGGGCTAAAAAAGGGACTCTTTTAGGCATTACTGGTCGAATCCAGACCCGCAATTATGAAAACCAACAAGGTCAGCGTGTTTACGTCACAGAAGTTGTTGCGGATAATTTCCAAATTTTGGAAAGTCGTGCTACACGTGAAGGTCAATCAAACAGTTATAATGCTGGTGGTAACAATAACTTTGGCGGAAATAATTTTTCTTCCCAAGGTTCTTCACAATCTCAAACGCCAAACTTTGCTAGAGATGAAAGTCCATTTGGTGATTCAAATCCTATGGATATTTCAGACGATGATCTTCCGTTTTAA","4.80","-3.00","18316","MINNVVLVGRMTRDAELRYTPSNQAVATFTLAVNRNFKNQNGEREADFINIVIWRQQAENLANWAKKGTLLGITGRIQTRNYENQQGQRVYVTEVVADNFQILESRATREGQSNSYNAGGNNNFGGNNFSSQGSSQSQTPNFARDESPFGDSNPMDISDDDLPF","1755875","","single-stranded DNA-binding protein","Periplasm, Cytoplasm, Extracellular","Matches i gapped BLAST to ssb proteins. Residues 1-164 are 74% similar to gi15675657 from S.pyogenes and 69% similar to gi15901384 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1713 (1e-67).","

InterPro
IPR000424
Family

Single-strand binding protein/Primosomal replication protein n
PF00436	$\"[2-103]T$	SSB
PS50935	$\"[1-104]T$	SSB

InterPro
IPR011344
Family

Single-strand binding protein
PTHR10302	$\"[34-164]T$	Single_strand_bd
TIGR00621	$\"[1-164]T$	ssb

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[2-139]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
PIRSF002070	$\"[2-146]T$	SSB
SSF50249	$\"[1-164]T$	Nucleic_acid_OB

","BeTs to 11 clades of COG0629COG name: Single-stranded DNA-binding proteinFunctional Class: LThe phylogenetic pattern of COG0629 is ----yqvCeBRhujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000424 (Single-strand binding protein family) with a combined E-value of 3.7e-38. IPB000424A 2-40 IPB000424B 63-85 IPB000424C 158-164","Residues 2-59 are 87% similar to a (DNA-BINDING SINGLE-STRAND REPLICATION) protein domain (PD186103) which is seen in Q9CDM9_LACLA.Residues 104-164 are 49% similar to a (BINDING SINGLE ORF9 STRAND) protein domain (PD234635) which is seen in Q9FDF5_STRPY.Residues 66-103 are 86% similar to a (BINDING DNA DNA-BINDING SINGLE-STRAND) protein domain (PD187678) which is seen in Q9FDF5_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Mar 6 16:58:18 2002","Wed Mar 6 16:53:09 2002","Fri Aug 18 16:08:39 2006","Tue Oct 15 17:53:35 2002","Wed Mar 6 16:53:09 2002","Wed Mar 6 16:53:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1693 is paralogously related (blast p-value < 1e-3) to SMu1785, also a predicted ssb protein.","Wed Mar 6 17:05:36 2002","Fri Aug 18 16:08:39 2006","pdb1EYGA Chain A, Crystal Structure Of Chymotryptic Fragment ... 69 4e-013pdb1QVCA Chain A, Crystal Structure Analysis Of Single Strand... 69 4e-013pdb1KAWA Chain A, Structure Of Single Stranded Dna Binding Pr... 69 4e-013","SMU.1859c","","Residues 2 to 104 (E-value = 1.5e-36) place SMu1693 in the SSB family which is described as Single-strand binding protein family (PF00436)","Wed Mar 6 16:53:09 2002","","","","Steffen SE, Katz FS, Bryant FR.Complete inhibition of streptococcus pneumoniae RecA protein-catalyzed ATP hydrolysis by SSB protein:Implications for the mechanism of SSB protein-stimulated DNA strand exchange.J Biol Chem. 2002 Feb 19 PMID: 11854290","","Wed Mar 6 17:04:26 2002","1","","","SMU.1859c","721" "SMu1694","1756661","1756371","291","ATGGCTAAATACGAAATTCTTTATATCATTCGTCCAAACATTGAAGAAGAAGCGAAAAACGCTTTGGTAGCACGTTTTGATGCTGTTTTGACTGACAATGGTGCAACTATTGTTGAATCAAAAGATTGGGAAAAACGTCGTCTAGCATATGAAATCCAAGATTTCCGTGAAGGACTTTACCATGTCATTAATGTTGAAACTGAAGATGCCCATGCTCTTAACGAGTTTGACCGTCTATCAAAAATCAATAATGACATTCTTCGTCATATGATCGTTAAACTTGACGCTTAA","4.90","-5.28","11230","MAKYEILYIIRPNIEEEAKNALVARFDAVLTDNGATIVESKDWEKRRLAYEIQDFREGLYHVINVETEDAHALNEFDRLSKINNDILRHMIVKLDA","1756387","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1841 (rps10);SMu1838 (rps19); SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA) and SMu1692 (rpsR).For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1828 (rs8); SMu1819 (rs13) SMu1819 (rs13); SMu1819 (rs13); SMu1818 (rs11) and SMu1692 (rs18). ","30S ribosomal protein S6","Cytoplasm","Matches in gapped BLAST to 30S ribosomal protein S6 sequences. Residues 1-96 are 88% similar to gi|15675658 from S.pyogenes and 86% similar to gi|15901385 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1714 (3e-46).","

InterPro
IPR000529
Family

Ribosomal protein S6
PD003809	$\"[38-89]T$	Ribosomal_S6
PF01250	$\"[2-94]T$	Ribosomal_S6
TIGR00166	$\"[1-96]T$	S6

InterPro
IPR014717
Domain

Translation elongation factor EF1B/ribosomal protein S6, conserved
G3DSA:3.30.70.60	$\"[1-95]T$	Transl_elong_EF1B/rib_con

noIPR
unintegrated

unintegrated
SSF54995	$\"[1-96]T$	SSF54995

","BeTs to 12 clades of COG0360COG name: Ribosomal protein S6Functional Class: JThe phylogenetic pattern of COG0360 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000529 (Ribosomal protein S6) with a combined E-value of 8.3e-13. IPB000529A 4-17 IPB000529B 44-60","Residues 1-95 are 72% similar to a (RIBOSOMAL 30S RRNA-BINDING CHLOROPLAST) protein domain (PD003809) which is seen in RS6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 14:08:10 2002","Wed Mar 6 17:10:09 2002","Wed Mar 6 17:13:58 2002","Thu Apr 4 14:56:39 2002","Wed Mar 6 17:10:09 2002","Wed Mar 6 17:10:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1694 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Mar 6 17:13:58 2002","","No significant hits to the NCBI PDB database.","SMU.1860c","","Residues 2 to 94 (E-value = 1.6e-28) place SMu1694 in the Ribosomal_S6 family which is described as Ribosomal protein S6 (PF01250)","Wed Mar 6 17:10:09 2002","","","","","","","1","","","SMU.1860c","855" "SMu1695","1757062","1756817","246","ATGAATCAGAAATCTAAAAAATCGTTGACTCCACTTGTACTTGGTATTTTTTCTCTTCCCTTTGCTATTTTTCCAGCGATTGTTGGTTTAATTCTCGGTATCGCTGGACTTATACTTGCTATCAACAAAAATAAAGAAGAGGAATTTAATTATAGGATTGAAATTATTTTGAACAGTCTTGGTATTATTATCGCAGCTATTAATATGATTATTGGGTTTATTCAAGGTTTCAACAATGGAATGTGA","10.10","1.98","8801","MNQKSKKSLTPLVLGIFSLPFAIFPAIVGLILGIAGLILAINKNKEEEFNYRIEIILNSLGIIIAAINMIIGFIQGFNNGM","1756833","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu1695 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[21-41]?$ $\"[55-77]?$	transmembrane_regions

InterPro
IPR000086
Domain

NUDIX hydrolase
G3DSA:3.90.79.10	$\"[242-377]T$	NUDIX_hydrolase

InterPro
IPR000445
Domain

Helix-hairpin-helix motif
PF00633	$\"[112-141]T$	HHH

InterPro
IPR003265
Domain

HhH-GPD
PF00730	$\"[48-183]T$	HhH-GPD
SM00478	$\"[52-203]T$	ENDO3c

InterPro
IPR003583
Domain

Helix-hairpin-helix DNA-binding, class 1
SM00278	$\"[122-141]T$	HhH1

InterPro
IPR005760
Family

A/G-specific adenine glycosylase MutY, bacterial form
TIGR01084	$\"[19-295]T$	mutY

InterPro
IPR011257
Domain

DNA glycosylase
SSF48150	$\"[16-236]T$	DNA_glycsylse

InterPro
IPR015797
Domain

NUDIX
SSF55811	$\"[241-381]T$	NUDIX_hydrolase

noIPR
unintegrated

unintegrated
G3DSA:1.10.340.30	$\"[34-145]T$	G3DSA:1.10.340.30
PTHR10359	$\"[36-241]T$	PTHR10359
PTHR10359:SF1	$\"[36-241]T$	PTHR10359:SF1

","BeTs to 7 clades of COG1194COG name: A/G-specific DNA glycosylaseFunctional Class: LThe phylogenetic pattern of COG1194 is --t-----ebrhuj---lin-Number of proteins in this genome belonging to this COG is 1","***** IPB001502 (Endonuclease III) with a combined E-value of 4.8e-11. IPB001502A 31-52 IPB001502C 113-144 IPB001502D 150-176 IPB001502E 194-221","Residues 72-161 are 62% similar to a (ENDONUCLEASE COMPLETE PROTEOME III) protein domain (PD001558) which is seen in Q9KEC2_BACHD.Residues 24-70 are 51% similar to a (GLYCOSYLASE PROTEOME COMPLETE ADENINE) protein domain (PD100362) which is seen in Q9HPQ6_HALN1.Residues 72-161 are 29% similar to a (DNA LYASE GLYCOSIDASE GLYCOSYLASE) protein domain (PD007425) which is seen in O26858_METTH.Residues 41-70 are 76% similar to a (GLYCOSYLASE ADENINE COMPLETE PROTEOME) protein domain (PD339571) which is seen in Q9KUR3_VIBCH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 10:34:52 2006","Tue Sep 19 10:29:07 2006","Tue May 3 12:04:50 2005","Tue Apr 2 11:12:23 2002","Wed Mar 6 17:22:26 2002","Wed Mar 6 17:22:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1697 is paralogously related (blast p-value < 1e-3) to SMu1502, a predicted endonuclease III.","Wed Mar 6 17:33:45 2002","Tue May 3 12:04:50 2005","pdb1MUYA Chain A, Catalytic Domain Of Muty From Escherichia C... 175 1e-044pdb1MUN Catalytic Domain Of Muty From Escherichia Coli D13... 173 4e-044","SMU.1865","","Residues 48 to 183 (E-value = 4.3e-17) place SMu1697 in the HhH-GPD family which is described as HhH-GPD superfamily base excision DNA repair protein (PF00730)Residues 112 to 141 (E-value = 4.7e-07) place SMu1697 in the HHH family which is described as Helix-hairpin-helix motif (PF00633)","Tue May 3 12:04:50 2005","24380223","","","Tsai-Wu JJ, Radicella JP, Lu AL.Nucleotide sequence of the Escherichia coli micA gene required for A/G-specific mismatch repair: identity of micAand mutY.J Bacteriol. 1991 Mar;173(6):1902-10.PMID: 2001994 ","","Wed Mar 6 17:33:45 2002","1","","","SMU.1865","465" "SMu1698","1760989","1759940","1050","ATGAAAACAGCAGTGTTTGTAAAAGCTGGTCAAATGGCCATTGAAACTATTGAGAAGCCAAGTGTTATTGAAGTTGATGATGCGATCATCCGTGTCGTCCGTGCTTGTGTCTGTGGTTCTGATCTGTGGTCTTATCGTGGAGATGATGACAAAGCTACGCATTCAGCCAACTCAGGTCACGAAATTATCGGAATCGTTGATGAAGTTGGCTCTGCTATTAATACAGTGAAAAAAGGAGACTTTGTTATTGCACCATTCACGCATGGTTGCGGTCATTGTGCAGCTTGTCGTGCTGGTTTTGAAGGAGGTTGTCAAGGACACGATCGGTCAACAAACTTTTCAAGTGGTTATCAAGCCGAATATGTTCGTTATGCTCATGCTGATTGGTCTTTAGTAAAAATTCCGGGTCAACCTAGCGATTATTCAGAAGGTATGATTGCTTCGCTTTTAGCTTTGGCGGATGTTATGCCAACAGGCTATCATGCAGCGCGCGTGGCCAATGTTCAAAAGGGGGATACGGTTGCAGTTGTTGGCGATGGAGCGGTTGGACTCTGTGCTGTTATCGCAGCTAAAATGCGTGGAGCTAAACGTATCATTATCATGAGTCGCCACAAGGATCGTCAGGAATTGGCGTTGGAATTTGGCGCTACTGATATTGTAGAAGAGCGCGGCGAAGAAGGTGTAGCTAAAGTTCTTGAACTGACAAATGGCGATGGTGTTGATGCCGCTCTTGAATGTGTCGGAACTCAGCTGTCTACTGAAACAGCGTTAGCTATTGCCCGTCCAGGTGCATCTATCGGTCGCGTGGGTGTTCCACATACCAAAGATATTAATCTTTCCGATTACTTCTTCCAAAACGCTATTATTGCAGGTGGACCAGCATCAGTAACGACTTATGACAAATCGGTTCTTCTCAAGGCTGTTCTTGATGGTGAGATTAATCCAGGAAAGGTCTTCACTCAATCTTACAGCTTAGATGATATTGATCAAGCCTATAAGGATATGCAGGAGCGCAAGACCATTAAGTCTATGGTTGTCGTTAGCAAATGA","5.50","-8.20","37060","MKTAVFVKAGQMAIETIEKPSVIEVDDAIIRVVRACVCGSDLWSYRGDDDKATHSANSGHEIIGIVDEVGSAINTVKKGDFVIAPFTHGCGHCAACRAGFEGGCQGHDRSTNFSSGYQAEYVRYAHADWSLVKIPGQPSDYSEGMIASLLALADVMPTGYHAARVANVQKGDTVAVVGDGAVGLCAVIAAKMRGAKRIIIMSRHKDRQELALEFGATDIVEERGEEGVAKVLELTNGDGVDAALECVGTQLSTETALAIARPGASIGRVGVPHTKDINLSDYFFQNAIIAGGPASVTTYDKSVLLKAVLDGEINPGKVFTQSYSLDDIDQAYKDMQERKTIKSMVVVSK","1759956","For other 'adh' genes see SMu0107 (adh);SMu0113 (adhA); SMu0114 (adhB); SMu0115 (adhC); SMu0116 (adhD); SMu0131 (adhE) and SMu1299 (adhD).","alcohol dehydrogenase","Cytoplasm","Matches in gapped BLAST to alcohol dehydrogenases. Residues 1-347 are 63% similar to gi|15901683 from S.pneumoniae. Residues 1-349 are 52% similar to gi|15673531 from L.lactis.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0428 (1e-113).","

InterPro
IPR002085
Family

Alcohol dehydrogenase superfamily, zinc-containing
PTHR11695	$\"[11-86]T$ $\"[112-347]T$	ADH_Sf_Zn

InterPro
IPR002328
Domain

Alcohol dehydrogenase, zinc-containing
PS00059	$\"[59-73]?$	ADH_ZINC

InterPro
IPR011032
Domain

GroES-like
SSF50129	$\"[1-191]T$ $\"[304-347]T$	GroES_like

InterPro
IPR013149
Domain

Alcohol dehydrogenase, zinc-binding
PF00107	$\"[170-310]T$	ADH_zinc_N

InterPro
IPR013154
Domain

Alcohol dehydrogenase GroES-like
PF08240	$\"[25-134]T$	ADH_N

noIPR
unintegrated

unintegrated
G3DSA:3.90.180.10	$\"[1-216]T$	G3DSA:3.90.180.10
PTHR11695:SF38	$\"[11-86]T$ $\"[112-347]T$	PTHR11695:SF38
SSF51735	$\"[146-304]T$	SSF51735

","BeTs to 5 clades of COG1063COG name: Threonine dehydrogenase and related Zn-dependent dehydrogenasesFunctional Class: E,RThe phylogenetic pattern of COG1063 is ---kY-V-EB-h---------Number of proteins in this genome belonging to this COG is 1","***** IPB002328 (Zinc-containing alcohol dehydrogenase) with a combined E-value of 1.5e-21. IPB002328A 12-43 IPB002328B 55-80 IPB002328C 90-104 IPB002328D 137-184","Residues 77-131 are 52% similar to a (DEHYDROGENASE OXIDOREDUCTASE ZINC) protein domain (PD270368) which is seen in Q9CFD2_LACLA.Residues 1-73 are 47% similar to a (DEHYDROGENASE OXIDOREDUCTASE ZINC) protein domain (PD015380) which is seen in Q9HMB6_HALN1.Residues 1-70 are 35% similar to a (OXIDOREDUCTASE DEHYDROGENASE ZINC ALCOHOL NAD COMPLETE) protein domain (PD225307) which is seen in Q9I1V7_PSEAE.Residues 132-170 are 71% similar to a (DEHYDROGENASE PROTEOME COMPLETE ALCOHOL) protein domain (PD405920) which is seen in Q9CFD2_LACLA.Residues 26-99 are 32% similar to a (PROTEOME COMPLETE ALCOHOL) protein domain (PD065028) which is seen in YDJL_ECOLI.Residues 267-349 are 51% similar to a (PROTEOME COMPLETE DEHYDROGENASE) protein domain (PD391912) which is seen in Q9CFD2_LACLA.Residues 184-266 are 61% similar to a (OXIDOREDUCTASE DEHYDROGENASE ZINC ALCOHOL NAD COMPLETE) protein domain (PD000104) which is seen in Q9CFD2_LACLA.Residues 23-346 are 24% similar to a (ALCOHOL DEHYDROGENASE OXIDOREDUCTASE ZINC) protein domain (PD201070) which is seen in O87871_THAAR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 16:12:10 2002","Wed Mar 6 17:40:23 2002","Tue Oct 15 16:12:10 2002","Thu Apr 4 14:21:18 2002","Wed Mar 6 17:40:23 2002","Wed Mar 6 17:40:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1698 is paralogously related (blast p-value < 1e-3) to SMu0107, a predicted alcohol dehydrogenase class III.","Wed Mar 6 17:51:39 2002","Wed Mar 6 17:40:23 2002","pdb|1YKF|A Chain A, Nadp-Dependent Alcohol Dehydrogenase From T... 111 1e-025pdb|1KEV|A Chain A, Structure Of Nadp-Dependent Alcohol Dehydro... 110 3e-025pdb|1TEH|A Chain A, Structure Of Human Liver Chichi Alcohol Deh... 97 3e-021","SMU.1867c","","Residues 7 to 347 (E-value = 3.7e-62) place SMu1698 in the ADH_zinc_N family which is described as Zinc-binding dehydrogenase (PF00107)","Wed Mar 6 17:40:23 2002","24380224","","","Hillman JD, Brooks TA, Michalek SM, Harmon CC, Snoep JL, van Der Weijden CC.Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental caries.Infect Immun. 2000 Feb;68(2):543-9.PMID: 10639415 ","","Wed Mar 6 17:49:45 2002","1","","","SMU.1867c","533" "SMu1699","1761401","1761087","315","ATGACAAAAGTAGTTACAGATGCAACTTTTGAAGCTGAAACGGCTAAGGGACTTGTACTTGTTGATTTTTGGGCAACATGGTGTGGTCCATGTCTTATGCAGGCGCCAATTTTGGAACAGCTTTCAGAAGAATTAGATGAAGATGAACTCAAAATTGTTAAGCTTGATGTGGATGAAAATCCTAATACAGCACAAAATTTTGGCATCATGTCGATTCCAACTTTGCTTTTTAAAAAGGATGGCGAAGTTGTCAAACAAGTTGCAGGTGTTCATACGAAAGATCAAATTAAGGCTATTGTAGCCGAACTTGCATAG","4.20","-8.86","11430","MTKVVTDATFEAETAKGLVLVDFWATWCGPCLMQAPILEQLSEELDEDELKIVKLDVDENPNTAQNFGIMSIPTLLFKKDGEVVKQVAGVHTKDQIKAIVAELA","1761103","For other 'trx' genes see SMu0792 (trxB); SMu1789 (trxH) and SMu0420 (trxB)","thioredoxin","Cytoplasm, Extracellular","Matches in gapped BLAST to thioredoxins. Residues 1-104 are 72% similar to gi15901605 from S.pneumoniae and 70% to gi15675662 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1717 (4e-39).","

InterPro
IPR005746
Family

Thioredoxin
TIGR01068	$\"[5-104]T$	thioredoxin

InterPro
IPR006662
Domain

Thioredoxin-related
PR00421	$\"[19-27]T$ $\"[27-36]T$ $\"[68-79]T$	THIOREDOXIN
PS00194	$\"[20-38]T$	THIOREDOXIN

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[15-104]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[1-102]T$	IPR012336

InterPro
IPR013766
Domain

Thioredoxin domain
PF00085	$\"[1-103]T$	Thioredoxin

InterPro
IPR015467
Domain

Thioredoxin family
PTHR10438	$\"[19-104]T$	Trx

noIPR
unintegrated

unintegrated
PTHR10438:SF13	$\"[19-104]T$	PTHR10438:SF13

","BeTs to 15 clades of COG0526COG name: Thiol-disulfide isomerase and thioredoxinsFunctional Class: O,CThe phylogenetic pattern of COG0526 is AMTkYQVCEBRHUJgpoLINXNumber of proteins in this genome belonging to this COG is 4","***** IPB000063 (Thioredoxin) with a combined E-value of 4.1e-08. IPB000063 19-32","Residues 55-97 are 55% similar to a (THIOREDOXIN REDOX-ACTIVE CENTER ELECTRON) protein domain (PD374254) which is seen in THIO_HELPY.Residues 55-96 are 59% similar to a (REDOX-ACTIVE CENTER THIOREDOXIN TRANSPORT) protein domain (PD000611) which is seen in Q9S386_LISMO.Residues 56-89 are 79% similar to a (THIOREDOXIN REDOX-ACTIVE CENTER ELECTRON TRANSPORT) protein domain (PD009023) which is seen in Q9CF37_LACLA.Residues 5-37 are 78% similar to a (ISOMERASE REDOX-ACTIVE CENTER PRECURSOR DISULFIDE) protein domain (PD003146) which is seen in Q9CF37_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 10:25:08 2006","Wed Mar 6 17:52:50 2002","Thu Sep 28 10:25:08 2006","Mon Apr 8 09:25:58 2002","Wed Mar 6 17:52:50 2002","Wed Mar 6 17:52:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1699 is paralogously related (blast p-value < 1e-3) to SMu1070, a thioredoxin family protein.","Wed Mar 6 17:57:36 2002","Thu Sep 28 10:25:08 2006","pdb1QUWA Chain A, Solution Structure Of The Thioredoxin From ... 93 1e-020pdb1XOA Thioredoxin (Oxidized Disulfide Form), Nmr, 20 Str... 83 8e-018pdb2TRXA Chain A, Thioredoxin >gi230778pdb2TRXB Chain B, ... 83 8e-018","SMU.1869c","","Residues 1 to 104 (E-value = 5.4e-33) place SMu1699 in the Thioredoxin family which is described as Thioredoxin (PF00085)","Wed Mar 6 17:52:50 2002","","","","Scharf C, Riethdorf S, Ernst H, Engelmann S, Volker U, Hecker M.Thioredoxin is an essential protein induced by multiple stresses in Bacillus subtilis.J Bacteriol. 1998 Apr;180(7):1869-77.PMID: 953738","","Wed Mar 6 18:03:49 2002","1","","","SMU.1869c","856" "SMu1700","1763806","1761476","2331","ATGAATACAAAGATTTTAAAAGCCTTAGAATTTGATAAGGTTAAAAAGCAATTTACTCATTTCTTGCAGAGTGAGCAAGGGCAAATGGAATTAAACGATTTATTACCTATGACCAATCAGGAAAAAATTGAACGTTCTTTTGCTGAAATTGCAGATGTAGCACAGATTTTTCAGGAGTATGCTTCCTTTGGCTTTGGGCACAGTCAGGATATTTCAGAAAGTTTACGTCGTTTAGAATTAGGAGCGGATCTCAATACTCAAGAGCTTTTGGCTGTCAAACGTATTTTGCAGATGTCAGCAGAGCTCAAGGACTTTTATGATAATTTAGAAAATGTTGATTTGCAAATTTTGGATTGCTTATTTGAAAAGATTGAAACGTTTCCTGATTTGCAAGGGAGTTTACAAGCCATCAATGATGGTGGCTTTATTGAAGATTTTGCTAGTCCTGAATTAACTAAAATTCGTCATCATATTCACCAAAATGAACAACAAATTCGTCAAATTCTTCAAGAAATGTTGAAGAAACAAGGTGATTTATTGGCTGAAAACCTTATTGCCAGTCGCAGTGGTCGCAGTGTTCTTCCAGTGAAAAATACTTATCGTCATCGTATTGCAGGTGTTATTCATGATATTTCAGCTTCAGGAAATACGGTTTACATTGAACCTCGAGCTGTTGTTAATTTAAATGAAGAGATGACTCAGGCGCGTGCAGACGAACGCCATGAAATGACTCGCATTTTACATGATTTATCCGATAGGCTAAGATCACAAACAGATATTATTGGTAATAATGCTTGGTTGCTTGGGCATATTGATTTTGTTCGTGGGAAATACCTTTATATGAGAGAAAATCAAGCCAGTCTTCCTAGTTTAACAACGGATCAAACTATCCGTCTTTTGAGTGTACGTCATCCTCTGCTAAGTAATCCAATTGCCAATGATTTACATTTTGAACATGATACAACAGCCATTTTAATTACAGGTCCTAATACGGGCGGTAAAACCATCATGTTAAAAACATTGGGAATAACACAACTGATGGCTCAGTCAGGTCTTCCTATTTTGGCTGATGAGGGAAGTAAGGTTGCTGTTTTTAAAGACATCTTTGCAGACATTGGTGATGAACAGTCCATTGAGCAAAGTTTATCCACTTTTTCAAGTCATATGACACATATTGTCGAAATTCTGCAAAAGGCCAATAAAGACAGCTTAGTCCTTTTTGATGAACTTGGTGCTGGTACGGATCCACAAGAAGGGGCAGCCTTGGCCATGAGTATTCTGGAACATTTACGCTTATCAGATATTAAAACAATGATTACCACCCATTATCCAGAGCTCAAGGCCTATGGTATCGAAACAGAATTTATTGAAAATGCGAGTATGGAATTTGATATGGTGACGCTCAGCCCCACCTATCATTTTATGCAAGGAGTACCGGGACGATCCAATGCTTTTGAGATTGCACGTCGTTTAGGTTTGTCTGAAATTATTGTTGCAGAAGCGGAAAATTTGACGAATACGGATTCAGATGTTAATAAAATTATCGAACGTTTGGAAAATCAAACCATTGAAAGTCGCAGACGTTTGGATAATATTCGTGAAGTGGAGCAGGAAAATCTCAAATTTAATCGAGCCGTCAAAAAACTTTATAATGAATTCTCACATGCACAAGACAAAGAGTTGCGTAAGGCCAAACTAAAGGCTCAAGAGATTGTTGACAAGGCTCTTGCAGAGAGTGATTTTATTCTCAAAAATCTTCAAGACAAAGCACAACTTAAGCCCCATGAAATTATTGAAGCTAAAGGCAAGCTCAAGAAGTTGGTTCCCGAGATAGAGCTTTCGAAAAATAAGGTTCTTAAAAAAGCTAAGAAGAAACGTGCTGCGAAAGTTGGAGATGATATTATTGTCAGCAGTTATGGGCAAAGAGGAACGCTTACTAAGCGCTTCAAAGATGGTCGTTGGGAAGCACAAGTAGGGCTGATCAAAATGACTTTACAAGAGTCAGAGTTTGATTTAGTGAAATCAGACAAAGCCCAAGCATCGCAGAAAAGACAAGCTCACCTTGTCAAAAGGACTTCTCAAAAGGCTCCTAGTGCTAGACTTGATTTACGTGGCAAGCGTTATGAAGAAGCGATGCAAGAATTAGATGAATTCATTGATCAGGCACTCTTGAACAATATGGCTCAGGTTGACATCATCCATGGTATCGGAACTGGTGTTATCCGTGATGGCGTAACTAAATATCTTCGCCGTAATAAGCAAGTTAAGGAGTTTGGCTATGCTCCTCAAAATGCAGGTGGTTCGGGCGCTACAATCGTGACTTTCAAATAG","6.60","-4.65","87758","MNTKILKALEFDKVKKQFTHFLQSEQGQMELNDLLPMTNQEKIERSFAEIADVAQIFQEYASFGFGHSQDISESLRRLELGADLNTQELLAVKRILQMSAELKDFYDNLENVDLQILDCLFEKIETFPDLQGSLQAINDGGFIEDFASPELTKIRHHIHQNEQQIRQILQEMLKKQGDLLAENLIASRSGRSVLPVKNTYRHRIAGVIHDISASGNTVYIEPRAVVNLNEEMTQARADERHEMTRILHDLSDRLRSQTDIIGNNAWLLGHIDFVRGKYLYMRENQASLPSLTTDQTIRLLSVRHPLLSNPIANDLHFEHDTTAILITGPNTGGKTIMLKTLGITQLMAQSGLPILADEGSKVAVFKDIFADIGDEQSIEQSLSTFSSHMTHIVEILQKANKDSLVLFDELGAGTDPQEGAALAMSILEHLRLSDIKTMITTHYPELKAYGIETEFIENASMEFDMVTLSPTYHFMQGVPGRSNAFEIARRLGLSEIIVAEAENLTNTDSDVNKIIERLENQTIESRRRLDNIREVEQENLKFNRAVKKLYNEFSHAQDKELRKAKLKAQEIVDKALAESDFILKNLQDKAQLKPHEIIEAKGKLKKLVPEIELSKNKVLKKAKKKRAAKVGDDIIVSSYGQRGTLTKRFKDGRWEAQVGLIKMTLQESEFDLVKSDKAQASQKRQAHLVKRTSQKAPSARLDLRGKRYEEAMQELDEFIDQALLNNMAQVDIIHGIGTGVIRDGVTKYLRRNKQVKEFGYAPQNAGGSGATIVTFK","1761492","For other 'mut' genes associated with repair and DNA mutation, see Smu0510; SMu0024 (mutT); SMu1697 (mutY);SMu1700 (mutS2);SMu1291 (mutT); SMu1325 (mutX); SMu1371 (mutR); SMu1468 (mutM); SMu0824 (mutT) and SMu0825 (mutT).","DNA mismatch repair protein","Cytoplasm","Matches in gapped BLAST to DNA mismatch repair proteins. Residues 1-774 are 69% similar to gi15675664 from S.pyogenes. Residues 1-776 are 65% similar to gi15902412 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1719 (0.0).","

InterPro
IPR000432
Domain

DNA mismatch repair protein MutS, C-terminal
PD001263	$\"[372-473]T$	MutS_C
PF00488	$\"[286-521]T$	MutS_V
SM00534	$\"[321-506]T$	MUTSac
PS00486	$\"[403-419]T$	DNA_MISMATCH_REPAIR_2

InterPro
IPR002625
Domain

Smr protein/MutS2 C-terminal
PF01713	$\"[701-776]T$	Smr
SM00463	$\"[698-776]T$	SMR
PS50828	$\"[701-776]T$	SMR

InterPro
IPR005747
Family

MutS 2 protein
PIRSF005814	$\"[1-776]T$	MutS_YshD
TIGR01069	$\"[1-776]T$	mutS2

InterPro
IPR007696
Domain

MutS III
SM00533	$\"[13-310]T$	MUTSd

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[286-511]T$	G3DSA:3.40.50.300
PTHR11361	$\"[326-714]T$	PTHR11361
PTHR11361:SF14	$\"[326-714]T$	PTHR11361:SF14
SSF48334	$\"[24-285]T$	SSF48334
SSF52540	$\"[286-512]T$	SSF52540
SSF81573	$\"[558-624]T$	SSF81573

","BeTs to 8 clades of COG1193COG name: MutS-like ATPases involved in mismatch repair, family 1Functional Class: LThe phylogenetic pattern of COG1193 is --tk-qvc-b--uj--o----Number of proteins in this genome belonging to this COG is 1","***** IPB000432 (DNA mismatch repair protein MutS family, C-terminal domain) with a combined E-value of 7.2e-27. IPB000432C 325-356 IPB000432D 366-414 IPB000432E 437-447 IPB000432F 470-501","Residues 501-614 are 42% similar to a (PROTEOME COMPLETE MISMATCH REPAIR) protein domain (PD396678) which is seen in Q9CF36_LACLA.Residues 271-501 are 60% similar to a (REPAIR DNA MISMATCH ATP-BINDING) protein domain (PD001263) which is seen in MUS2_BACSU.Residues 722-776 are 58% similar to a (MUTS2 ATP-BINDING DNA-BINDING COMPLETE) protein domain (PD013182) which is seen in Q9CF36_LACLA.Residues 458-539 are 35% similar to a (PROTEOME COMPLETE MISMATCH REPAIR) protein domain (PD291320) which is seen in Q9KFU5_BACHD.Residues 631-720 are 45% similar to a (PROTEOME DNA COMPLETE MISMATCH) protein domain (PD407224) which is seen in Q9CF36_LACLA.Residues 2-254 are 44% similar to a (MUTS2 ATP-BINDING DNA DNA-BINDING) protein domain (PD151475) which is seen in Q9CF36_LACLA.Residues 467-509 are 55% similar to a (PROTEOME COMPLETE MISMATCH REPAIR) protein domain (PD238738) which is seen in Q9K8A0_BACHD.Residues 542-772 are 24% similar to a (F16G16.7) protein domain (PD298572) which is seen in Q9SS53_ARATH.Residues 515-720 are 27% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in MUS2_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 16 08:39:20 2006","Wed Aug 16 08:39:20 2006","Tue May 3 12:05:31 2005","Tue Apr 2 11:13:15 2002","Wed Mar 6 18:05:44 2002","Wed Mar 6 18:05:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1700 is paralogously related (blast p-value < 1e-3) to SMu1898, a predicted hexA DNA mismatch repair protein.","Wed Mar 6 18:12:06 2002","Tue May 3 12:05:31 2005","pdb1EWRA Chain A, Crystal Structure Of Taq Muts >gi11514362... 113 1e-025pdb1EWQA Chain A, Crystal Structure Taq Muts Complexed With A... 112 2e-025pdb1E3MA Chain A, The Crystal Structure Of E. Coli Muts Bindi... 87 1e-017","SMU.1870c","","Residues 286 to 521 (E-value = 1.1e-15) place SMu1700 in the MutS_V family which is described as MutS domain V (PF00488)Residues 701 to 776 (E-value = 6.3e-35) place SMu1700 in the Smr family which is described as Smr domain (PF01713)","Tue May 3 12:05:31 2005","","","","Joshi A, Rao BJ.MutS recognition: Multiple mismatches and sequence context effects.J Biosci. 2001 Dec;26(5):595-606.PMID: 11807290","","Wed Mar 6 18:16:26 2002","1","","","SMU.1870c","176" "SMu1701","1764420","1763875","546","ATGATTTCGCTGCTAATTCTTCTGCTTTTAGCTTGGAATTTTTATATTGGCTATCATCGGGGTATTATTTTACAGACTTATTATGTTATAGCAAGTCTAATTTCCTTGGGAATCGCAATCGTTTACTATAAAAGGCTGGCAAATGTATTAACTCTTTGGATACCATATTCCAATGCTAGTGAGAATGCTTCTGTTGCCTTTTTTAAAACAGTAAATTTATTTGAATTGGATCAGGTATTCTATGCGGGTCTGGCTTTTTTTACTATTTACGTATTGGTTTATTTTGTTTTTCGCTTATTGGGGATTTTTGTTCATCTTGTGAAAACAGACCGTTTTAATAAGGAAACTCTCAATTATTTTAGTGGTGCAATGGCAGTATTAGTGACTATGCTGACTGTTAGTCTTTTTTTGAATGTTTTGGCAGCCATTCCTATGTCGAGTCTTCAAAATATTTTATCTGAAAGTTTAATGATTCGTTTACTGATTGACTTCCCCCTGTTTTCTTGGTTTATTAATTATTTTTGGGTAACAACAATAGTGAAGTGA","10.00","3.46","20877","MISLLILLLLAWNFYIGYHRGIILQTYYVIASLISLGIAIVYYKRLANVLTLWIPYSNASENASVAFFKTVNLFELDQVFYAGLAFFTIYVLVYFVFRLLGIFVHLVKTDRFNKETLNYFSGAMAVLVTMLTVSLFLNVLAAIPMSSLQNILSESLMIRLLIDFPLFSWFINYFWVTTIVK","1763891","","conserved hypothetical protein","Membrane, Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-180 are 45% similar to gi|15675665 from S.pyogenes and 35% similar to gi|15902411 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1720 (2e-41).","

InterPro
IPR003825
Family

Colicin V production protein
PF02674	$\"[1-176]T$	Colicin_V

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 20-162 are 33% similar to a (PROTEOME COMPLETE YQJB BH3108) protein domain (PD093870) which is seen in Q9CF35_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:35:54 2002","Fri Mar 8 14:34:50 2002","Tue Oct 8 15:35:54 2002","Fri Mar 8 14:34:50 2002","","Fri Mar 8 14:34:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1701 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:35:54 2002","","No significant hits to the NCBI PDB database.","SMU.1871c","","Residues 1 to 176 (E-value = 7.7e-29) place SMu1701 in the Colicin_V family which is described as Colicin V production protein (PF02674)","Fri Mar 8 14:34:50 2002","24380227","","","","","","1","","","SMU.1871c","973" "SMu1702","1764722","1764417","306","ATGACAAGCAAAAATCGTTACAAATTCACATTTGGTGAAAAAGCACTCACTTTAACAACAGATAAAGATAATCTATTTATGGAAGAAATTGAACGTGTTGCTAAAGAAAAATATGATGCTATCAAAGAGAAATTGCCTCAGGCAGACAATGAAACAATAGCTATCTTGATGGCCATTAATGCTTTATCAACTCAGTTGAGCCGAGAAATTGACTTTGATAAAAAGGAGGAAGAATTAGAAAAATTCAGGACAAAAGAATTATCTATTCTTAAAGATCGTGCTCAACGAAGCGGAGCTAAAAAATGA","9.00","1.00","11760","MTSKNRYKFTFGEKALTLTTDKDNLFMEEIERVAKEKYDAIKEKLPQADNETIAILMAINALSTQLSREIDFDKKEEELEKFRTKELSILKDRAQRSGAKK","1764433","","Streptococcus-specific protein","Cytoplasm","Limited matches in gapped BLAST to streptococcal conserved hypothetical proteins. Residues 1-96 are 66% similar to gi15675666 fromS.pyogenes. Residues 1-95 are 55% similar to gi15900323 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1721 (3e-32).","

noIPR
unintegrated

unintegrated
SSF102829	$\"[6-96]T$	SSF102829

InterPro
IPR001352
Family

Ribonuclease HII/HIII
PF01351	$\"[88-293]T$	RNase_HII

InterPro
IPR004641
Family

Ribonuclease HIII
TIGR00716	$\"[5-292]T$	rnhC

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[85-303]T$	RNaseH_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.10	$\"[86-252]T$	G3DSA:3.30.420.10

","BeTs to 4 clades of COG1039COG name: Ribonuclease HII Family 2Functional Class: LThe phylogenetic pattern of COG1039 is -----q---b----gp--in-Number of proteins in this genome belonging to this COG is 1","***** IPB001352 (Ribonuclease HII) with a combined E-value of 7.7e-08. IPB001352A 89-103 IPB001352B 124-133 IPB001352C 224-244","Residues 5-67 are 41% similar to a (RIBONUCLEASE HIII COMPLETE MAGNESIUM) protein domain (PD271472) which is seen in Q9CDG3_LACLA.Residues 34-146 are 40% similar to a (HIII NUCLEASE ENDONUCLEASE 3.1.26.-) protein domain (PD172377) which is seen in RNH3_BACSU.Residues 144-295 are 71% similar to a (HIII RIBONUCLEASE RNASE MAGNESIUM) protein domain (PD013060) which is seen in RNH3_STRPN.Residues 89-277 are 27% similar to a (HII RIBONUCLEASE HYDROLASE RNASE) protein domain (PD005501) which is seen in RNH2_PYRHO.Residues 4-142 are 30% similar to a (HIII NUCLEASE ENDONUCLEASE 3.1.26.-) protein domain (PD407660) which is seen in RNH3_CHLPN.Residues 87-141 are 72% similar to a (HIII RIBONUCLEASE RNASE MAGNESIUM) protein domain (PD337471) which is seen in RNH3_STRPN.Residues 89-240 are 28% similar to a (RNASE RIBONUCLEASE SUBUNIT HI) protein domain (PD003015) which is seen in RNH2_PYRAB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 12:57:30 2007","Tue Sep 19 10:50:35 2006","Tue Sep 19 10:45:22 2006","Tue Apr 9 09:04:58 2002","Fri Mar 8 14:40:33 2002","Fri Mar 8 14:40:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1703 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 8 14:49:36 2002","","No significant hits to the NCBI PDB database.","SMU.1873","","Residues 88 to 293 (E-value = 9.4e-55) place SMu1703 in the RNase_HII family which is described as Ribonuclease HII (PF01351)","Fri Mar 8 14:40:33 2002","24380229","","","","","","1","","","SMU.1873","466" "SMu1704","1765849","1766436","588","ATGAAAAGATTTTTAAAAGAATGGGGCCTTTTCTTGGTCATCATTTTCGCATTGCTACTCCCGCGTCTCTTTATCTGGTTTCCTGTCCAAGTAGATGGACATTCAATGGATCCTACCTTAGCCAATGGGGAGCATCTCATTGTCGTCAGGACAACTTCTATCAAACATTTTGACATTGTTGTTGCTGCTGAAGGCAATAAAAATATTGTCAAACGTGTGATTGGCATGCCCGGTGATACCATTACCTATGAAAATGATATGCTTTCTATTAATGGGAAAAAAGTCAATGAAACTTATCTCAAGCAATACAAGGATAAATTTGCCAAGGACAAACTCCAAAAGACTTATGCCTACAATCAGTATTTCCAAGAATTAGCCTCACAATCAACAGCTTTCACAACAGACGAACAAGGAAACGCCAGCTTTACGATTAAAGTACCAAAAGGACGTTACCTGCTTTTAGGTGATGATCGCATTGTCTCTAAAGACAGCCGCCATGTTGGAACTTTTGCTAAGAATAAAATTGTTGGTGAAGTTAAATTCCGCTTTTGGCCTTTAAACGCTATTCGTTTCATTTCAAATAAATAA","10.50","10.95","22412","MKRFLKEWGLFLVIIFALLLPRLFIWFPVQVDGHSMDPTLANGEHLIVVRTTSIKHFDIVVAAEGNKNIVKRVIGMPGDTITYENDMLSINGKKVNETYLKQYKDKFAKDKLQKTYAYNQYFQELASQSTAFTTDEQGNASFTIKVPKGRYLLLGDDRIVSKDSRHVGTFAKNKIVGEVKFRFWPLNAIRFISNK","1766446","For other 'lep' genes see SMu0862 (lepA) and SMu1271 (lepA).","signal peptidase I","Extracellular, Membrane, Cytoplasm","Matches in gapped BLAST to signal peptidase I sequences. Residues 1-187 are 61% similar to gi|15675668 from S.pyogenes. Residues 2-189 are 57% similar to gi|15902408 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1723 (2e-65).","

InterPro
IPR000223
Family

Peptidase S26A, signal peptidase I
PR00727	$\"[24-40]T$ $\"[69-81]T$ $\"[146-165]T$	LEADERPTASE
TIGR02227	$\"[8-187]T$	sigpep_I_bact
PS00501	$\"[33-40]?$	SPASE_I_1
PS00760	$\"[71-83]T$	SPASE_I_2

InterPro
IPR006198
Domain

Peptidase S24, S26A and S26B
PF00717	$\"[30-93]T$	Peptidase_S24

InterPro
IPR011056
Domain

Peptidase S24 and S26, C-terminal region
G3DSA:2.10.109.10	$\"[19-190]T$	Pept_S24_S26_C
SSF51306	$\"[22-192]T$	Pept_S24_S26_C

InterPro
IPR014037
Family

Peptidase S26A
PTHR12383	$\"[14-106]T$ $\"[144-190]T$	Peptidase_S26A

noIPR
unintegrated

unintegrated
PTHR12383:SF1	$\"[14-106]T$ $\"[144-190]T$	PTHR12383:SF1

","BeTs to 13 clades of COG0681COG name: Signal peptidase IFunctional Class: NThe phylogenetic pattern of COG0681 is AmTKYqvCeBrhuj--OLinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000508 (Signal peptidase) with a combined E-value of 5.6e-26. IPB000508A 18-48 IPB000508B 52-63 IPB000508C 69-79 IPB000508D 146-165","Residues 36-166 are 40% similar to a (I PEPTIDASE SIGNAL PROTEASE) protein domain (PD001438) which is seen in LEPQ_BACNA.Residues 146-189 are 70% similar to a (I PEPTIDASE SIGNAL LEADER) protein domain (PD204547) which is seen in LEP_STRPN.Residues 4-139 are 55% similar to a (I PEPTIDASE SIGNAL COMPLETE) protein domain (PD097105) which is seen in LEP_STRPN.Residues 84-179 are 33% similar to a (I PEPTIDASE SIGNAL HYDROLASE) protein domain (PD343894) which is seen in Q9ZG05_STACA.Residues 1-187 are 24% similar to a (TYPE-I SIPA PEPTIDASE SIGNAL) protein domain (PD342889) which is seen in Q9ZG06_STACA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 15:49:40 2002","Fri Mar 8 14:51:22 2002","Tue Oct 15 15:49:40 2002","Wed Apr 10 09:43:35 2002","Fri Mar 8 14:51:22 2002","Fri Mar 8 14:51:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1704 is paralogously related (blast p-value < 1e-3) to SMu1087, also a predicted signal peptidase I, and to SMu1275, a predicted repressor protein - phage associated.","Fri Mar 8 14:57:21 2002","","No significant hits to the NCBI PDB database.","SMU.1874","","Residues 1 to 177 (E-value = 2.4e-32) place SMu1704 in the Peptidase_S26 family which is described as Signal peptidase I (PF00461)","Fri Mar 8 14:51:22 2002","24380230","","","","","","1","","","SMU.1874","722" "SMu1705","1766522","1768885","2364","ATGACCTATTACTTTTCAGGCACCATTGACCGTGTTATTTTTGAAAATACCAGCAATTTTTTTAAAATTATTCTTCTGGAAATTGACGATACTGACAGCGATTTTGATGATTTTGAAATTATTGTGACAGGTACTATTGCTGATGTTATTGAAGGAGAAAACTATACTTTTTGGGGTGAATTGACCCAGCATCCTAAATATGGACAGCAGTTAAAAGTGGAAAGATACCAGCGTGCTAAACCCTCTTCTGCTGGTCTGATTAAGTATTTTTCCAGTCAGCATTTCAAGGGAATCGGGAAAAAAACAGCCGAAAAAATTATTCACTTATATGGTGATGACCCTATTGATAATATTCTGGAAGATCCTGATAAGTTAGAAAGCATTAGTGGACTTTCTAAGGCTAATAGAGAAAATTTAGTTAGTAAACTTCGTCTTAACTACGGTGCTGAACAGATTCTGGCAAAATTAGCAGAATATGGATTAAATAACAAAACAGCTGTTCAAATTTTTGAACGCTATAAAGAAGAAAGTTTGACTGTTATTACTGAAAATCCTTATCAACTGGTTGAGGACATTCAAGGCATTGGATTCAAAATGGCTGACAAATTAGCAGAACAAGTAGGTATTAACAGCGATGCTCCTCAGCGTTTTCGTGCTGCTCTTGTTCATACTCTTTTAGAAACCTCTATTGACAAAGGTGACACCTATATTGAAGCCAAAGAATTACTCGAAAAATCTCTTTTTATTCTTGAAGAGGTGAGACAAGTCGAACTGGATCCCAGTCAAATTGCTCAGGAACTGACACAATTAATCTCCGAAGATAAGGTACAAAATATTGGTACTAAAATCTTTGATAATACGCTTTTTTATGCCGAATCAGGCATTCATAAGCATCTTACCCGCATTCTGGATAGACCACTTGAAAAAGAGATCAGCAGCCAAGACATTCAAACTGAAATTAAACATATTCAAGCAGAATTTAATATTAACTATGACAAAGCACAAAAAAATGCTATCCAAAAAGCCATCCAAAGCAAGGTTTTCCTTTTAACAGGCGGTCCAGGAACCGGAAAAACGACTGTCATCAATGGAATTATTAAGGCTTATGCTAATTTGCATCAAATTGACCTGCAAAAAAGTGACCGACCTATTATTCTGGCTGCCCCGACTGGTCGTGCTGCTAGACGGATGAATGAGCTAACAGGTTTACCTAGTGCCACCATTCACCGGCATTTAGGACTTAATGGTGATAGTGAATATCAGGCACTTGATGATTTTCTGGATTGTGATCTCATTATTATTGACGAGTTTTCTATGGTTGATACTTGGCTAGCCAATCAATTGTTTAGTGCTATTGCTTCAAATACACAAGTTATCATTGTTGGTGATAGCGATCAGCTCCCATCCGTCGGTCCAGGTCAAATTTTGGCTGATTTACTGAAAATAAATAGATTACCGCAAGTTTCCTTAACTAAAATATTCAGGCAATCTGAGGACTCAACTATTGTCACACTTGCCAACCAGATTCGCCAAGGTCGTCTTCCAACTGACTTCACAGCTAAAAAGGCTGACCGTTCTTATTTTGAAGCACAGAGCACTCACATTCCGCAAATGATTCAAAAGATTGTCAGTTCTGCCCTTAAAAGTGGTATAGATGCTCAGGAAATACAGATTTTAGCACCGATGTATCGTGGGCAAGCAGGTATTACGCATCTTAATAAACTGATGCAAGATTTGCTCAATCCTTTAAATAACCAGTTAGAATTTCAATTTAATGACCTTCATTTTCGTAAGGGCGATAAAGTACTTCATCTTATCAACGATGCGCAAATTAACGTGTTTAATGGTGACATTGGGTACATTACTGATCTTATTCCTGCAAAATATACAGAGTCCAAACAAGATGAAATGATTCTGGATTTTGATGGAACTGAGATTAACTATCCTCGCAATGAATGGTTGAAAATAACACTCGCTTACGCTATGAGTATCCACAAATCTCAAGGCAGTGAATTTAAAGTAGTTATTCTTCCTGTCACACGCCAAAGCGGCAGACTTTTGCAACGCAATCTCATTTATACAGCTATCACACGCTCAAAAAGCAAACTTGTCATGTTGGGAGAAATTGCAGCCTTTGACAACGCCATCAAAAATGAAGGAACTAAAAGAAAAACTTATCTTATTGAACGCTTTAAGAAGGATGAATGCAGTGGCCACCATAACACCGAGAAAAATAAACAAGGAGTAAAAGAAAGTGCAGCTATATTAAAAGAAGATTTTATTTTGACAGAAAGAAATATCTTAACGATTGACCCTATGATTGGCTTATCTCAAGCTGACATTGACTTATTTTTTAAGAAATAA","5.60","-13.91","88880","MTYYFSGTIDRVIFENTSNFFKIILLEIDDTDSDFDDFEIIVTGTIADVIEGENYTFWGELTQHPKYGQQLKVERYQRAKPSSAGLIKYFSSQHFKGIGKKTAEKIIHLYGDDPIDNILEDPDKLESISGLSKANRENLVSKLRLNYGAEQILAKLAEYGLNNKTAVQIFERYKEESLTVITENPYQLVEDIQGIGFKMADKLAEQVGINSDAPQRFRAALVHTLLETSIDKGDTYIEAKELLEKSLFILEEVRQVELDPSQIAQELTQLISEDKVQNIGTKIFDNTLFYAESGIHKHLTRILDRPLEKEISSQDIQTEIKHIQAEFNINYDKAQKNAIQKAIQSKVFLLTGGPGTGKTTVINGIIKAYANLHQIDLQKSDRPIILAAPTGRAARRMNELTGLPSATIHRHLGLNGDSEYQALDDFLDCDLIIIDEFSMVDTWLANQLFSAIASNTQVIIVGDSDQLPSVGPGQILADLLKINRLPQVSLTKIFRQSEDSTIVTLANQIRQGRLPTDFTAKKADRSYFEAQSTHIPQMIQKIVSSALKSGIDAQEIQILAPMYRGQAGITHLNKLMQDLLNPLNNQLEFQFNDLHFRKGDKVLHLINDAQINVFNGDIGYITDLIPAKYTESKQDEMILDFDGTEINYPRNEWLKITLAYAMSIHKSQGSEFKVVILPVTRQSGRLLQRNLIYTAITRSKSKLVMLGEIAAFDNAIKNEGTKRKTYLIERFKKDECSGHHNTEKNKQGVKESAAILKEDFILTERNILTIDPMIGLSQADIDLFFKK","1768895","For other 'rec' genes see SMu0021 (recO);SMu0532 (recN); SMu0545 (recR),(recM);SMu1956 (recF); SMu1892 (recA) ; SMu0425 (recU); SMu1669 (recG) and SMu1339 (recJ).","exodeoxyribonuclease V alpha subunit","Cytoplasm, Extracellular","Matches in gapped BLAST to exodeoxyribonuclease V (alpha subunit) and to conjugation transfer proteins. Residues 1-787 are 65% similar to gi15675669 from S.pyogene and 60% similar to gi15902407 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1724 (0.0).","

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[344-495]T$	AAA

InterPro
IPR006345
Family

Helicase RecD/TraA
TIGR01448	$\"[5-731]T$	recD_rel

InterPro
IPR010994
Domain

RuvA domain 2-like
SSF47781	$\"[94-166]T$	RuvA_2_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[320-466]T$	G3DSA:3.40.50.300
SSF52540	$\"[320-719]T$	SSF52540

","BeTs to 6 clades of COG0507COG name: ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I memberFunctional Class: LThe phylogenetic pattern of COG0507 is -m--Y---ebrh----o-IN-Number of proteins in this genome belonging to this COG is 1","***** IPB000212 (UvrD/REP helicase) with a combined E-value of 1.6e-12. IPB000212A 352-362 IPB000212B 384-401 IPB000212F 659-677 IPB000212G 687-699","Residues 405-479 are 58% similar to a (V EXODEOXYRIBONUCLEASE PROTEOME COMPLETE) protein domain (PD360018) which is seen in Q9CEU4_LACLA.Residues 159-412 are 25% similar to a (PROTEOME MJ1519 COMPLETE) protein domain (PD116435) which is seen in Q58914_METJA.Residues 586-660 are 68% similar to a (PROTEOME COMPLETE EXODEOXYRIBONUCLEASE) protein domain (PD413493) which is seen in Q9CEU4_LACLA.Residues 662-731 are 62% similar to a (HELICASE DNA COMPLETE PROTEOME ATP-DEPENDENT ATP-BINDING) protein domain (PD002094) which is seen in Q9CEU4_LACLA.Residues 599-718 are 40% similar to a (V EXODEOXYRIBONUCLEASE ALPHA PROTEOME) protein domain (PD008273) which is seen in O84036_CHLTR.Residues 4-83 are 52% similar to a (PROTEOME COMPLETE EXODEOXYRIBONUCLEASE) protein domain (PD134882) which is seen in Q9CEU4_LACLA.Residues 84-295 are 54% similar to a (V PROTEOME EXODEOXYRIBONUCLEASE COMPLETE) protein domain (PD188445) which is seen in Q9CEU4_LACLA.Residues 488-582 are 56% similar to a (V EXODEOXYRIBONUCLEASE ALPHA PROTEOME) protein domain (PD101002) which is seen in Q9CEU4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 16 08:45:07 2006","Thu May 2 12:49:11 2002","Wed Aug 16 08:45:07 2006","Wed Apr 3 09:16:38 2002","Fri Mar 8 15:06:09 2002","Fri Mar 8 15:06:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1705 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Apr 3 09:16:38 2002","","No significant hits to the NCBI PDB database.","SMU.1875","","No significant hits to the Pfam 11.0 database","Fri Mar 8 15:06:09 2002","24380231","","","","","","1","","","SMU.1875","177" "SMu1706","1768984","1769454","471","ATGATATCATACGAAAAAACAGCCCGAGCTTTTAAAAGCAGCACTATTGCTATCGCTGTTCTTAATATTTTGACCTTTGTCTTGGGGCTTTGGGGATTACTTGGCATTGTTTCCATACAACAAGCAATGAAAAATGGAACCATTGATAAATTTAACCTAACAGCAAAACAACTAGCTGCAGTTAAACAAAGTATTACACCATTATCTATCTCGATTACTATCTTGGCAATTATTATTGCTGCTACAATTGCTGTCTTTTGTTTTCTTAATCTTTCAAAATTAAAAAAGCAACAAACTATCAGCTTTATTCCTTACTATTTGGGTATTGGTATTAAAACGTTTGACATTATCTATAGCCTTATCTTTGGAACATTTGCCGTTTTTTCATTAATTATTCAAATTGCTTTTATTGTTCTTTATTTCTATACTATCCAAAAAGCAAGGATACTAGCAGAAAAAGAAGAGGCTTAA","10.50","7.93","17250","MISYEKTARAFKSSTIAIAVLNILTFVLGLWGLLGIVSIQQAMKNGTIDKFNLTAKQLAAVKQSITPLSISITILAIIIAATIAVFCFLNLSKLKKQQTISFIPYYLGIGIKTFDIIYSLIFGTFAVFSLIIQIAFIVLYFYTIQKARILAEKEEA","1769464","","conserved hypothetical protein","Membrane, Cytoplasm","Single match in gapped BLAST to gi|15675670, a hypothetical from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1725 (3e-15).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[69-89]?$ $\"[94-114]?$ $\"[120-140]?$	transmembrane_regions

InterPro
IPR004701
Domain

Phosphotransferase system, fructose subfamily IIA component
G3DSA:3.40.50.510	$\"[2-140]T$	PTS_EIIA_fruc
PF03610	$\"[3-123]T$	EIIA-man
PS51096	$\"[2-130]T$	PTS_EIIA_TYPE_4
SSF53062	$\"[2-134]T$	PTS_EIIA_fruc

InterPro
IPR004720
Domain

Phosphotransferase system, sorbose subfamily IIB component
PD008332	$\"[176-321]T$	PTSIIB_sorb
G3DSA:3.40.35.10	$\"[168-326]T$	PTS_IIB_sorb
PF03830	$\"[169-319]T$	PTSIIB_sorb
PS51101	$\"[166-330]T$	PTS_EIIB_TYPE_4
SSF52728	$\"[168-330]T$	PTS_IIB_sorb

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 122-169 are 70% similar to a (SYSTEM MANNOSE-SPECIFIC COMPONENT IIAB) protein domain (PD244943) which is seen in Q9S4L5_STRSL.Residues 1-121 are 80% similar to a (COMPONENT SYSTEM COMPLETE PROTEOME) protein domain (PD328938) which is seen in Q9S4L5_STRSL.Residues 170-324 are 89% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIB) protein domain (PD008332) which is seen in Q9S4L5_STRSL.Residues 15-133 are 31% similar to a (SYSTEM PTS N DOMAIN) protein domain (PD009343) which is seen in Q47350_ECOLI.Residues 6-102 are 77% similar to a (COMPONENT SYSTEM IIA PHOSPHOTRANSFERASE) protein domain (PD403187) which is seen in Q9CEX8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 12:58:05 2007","Wed Sep 6 18:47:42 2006","Wed Sep 6 18:43:24 2006","Fri Mar 8 15:11:52 2002","","Fri Mar 8 15:11:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1707 is paralogously related (blast p-value < 1e-3) to SMu0089, a predicted sorbose PTS system, IIB component, to SMu1780, a probable PTS system fructose-specific enzyme IIA component, to SMu1779, a probable PTS system fructose-specific enzyme IIB component, and to SMu0092, a predicted PTS system, IIA component.","Fri Mar 8 15:53:59 2002","Wed Sep 6 18:43:24 2006","pdb1BLE Phosphoenolpyruvate-Dependent Phosphotransferase Sy... 139 3e-034pdb1PDO Phosphoenolpyruvate-Dependent Phosphotransferase S... 84 2e-017","SMU.1877","","Residues 3 to 123 (E-value = 2e-54) place SMu1707 in the EIIA-man family which is described as PTS system fructose IIA component (PF03610)Residues 169 to 319 (E-value = 6e-87) place SMu1707 in the PTSIIB_sorb family which is described as PTS system sorbose subfamily IIB component (PF03830)","Wed Sep 6 18:43:24 2006","24380233",""," Abranches J, Candella MM, Wen ZT, Baker HV, Burne RA.Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans.J Bacteriol. 2006 Jun;188(11):3748-56. PMID: 16707667","Lortie,L.A., Pelletier,M., Vadeboncoeur,C. and Frenette,M.The gene encoding IIAB(Man)L in Streptococcus salivarius is part of a tetracistronic operon encoding a phosphoenolpyruvate:mannose/glucose phosphotransferase systemMicrobiology 146 (Pt 3), 677-685 (2000)PubMed: 10746771","Fri Mar 16 12:58:05 2007","Thu Apr 11 11:03:35 2002","1","","","SMU.1877","270" "SMu1708","1771358","1772176","819","ATGTCAGTTATTTCTATTATTTTGGTCCTCATCATCGCCTTCCTTGCAGGTCTTGATGGTATCTTGGACCAATTTCAATTCCACCAACCACTTGTATCTTGTACCTTGATTGGTTTAGCATCTGGTCACACAGTTGCAGGTATTATGCTTGGGGGAACCTTGCAATTTCTTGCTCTTGGTTGGGCAAATATCGGTGCTGCTGTTGCTCCTGATGTCGCACTCGCTTCAACTGCAGCGGCAGTCATTATGATTAAAGGAGGAGATTTTTCACAAAAAGGTATTACCATTGCCTATGGTGTTGCAGTCCCTCTTGCTATTGCCGGTCTTGCACTAACAATGGTGGTACGCGCTATTTCAATTGGTATCGTCCATGGAGCCGATGCTGCCGCAAAGAATGGTAATATTCGTGCTGTTGAACGCTCACATTATTTTGCTCTTCTTCTTCAAGGTCTTCGTATCGTTTTCCCTGTTGCCCTGCTTCTTGCACTCCCCGCTAATCATGTTAAATCAATACTGGAAGCTATCCCTAGTTGGCTATCTGATGGTATGACTATTGGCGGTGGTATGGTAGTCGCCGTAGGTTATGCAATGATCCTTAACATGATGGCTACAAGAGAAGTCTGGCCATTCTTTATTATCGGTTTTGTTCTCGCCGCTATCCCAGATACACAAATTACTTTGTTTGGACTTGGTATGATAGGTGTAGCACTTGCCATGATTTATATCGCCCTTACTAATCAAACTGGTAGAAACAGTAGTAGTGGACAAGCGTCTTCCAGTTCAAACGATCCAATTGGCGATATCTTAGAGGATTACTAG","6.00","-2.86","28088","MSVISIILVLIIAFLAGLDGILDQFQFHQPLVSCTLIGLASGHTVAGIMLGGTLQFLALGWANIGAAVAPDVALASTAAAVIMIKGGDFSQKGITIAYGVAVPLAIAGLALTMVVRAISIGIVHGADAAAKNGNIRAVERSHYFALLLQGLRIVFPVALLLALPANHVKSILEAIPSWLSDGMTIGGGMVVAVGYAMILNMMATREVWPFFIIGFVLAAIPDTQITLFGLGMIGVALAMIYIALTNQTGRNSSSGQASSSSNDPIGDILEDY","1772186","For other 'ptn' genes see SMu1777 (ptnD) and SMu1709 (ptnD).For other 'man' genes see SMu1675 (manA) and SMu1707 (manL).","mannose PTS system component IIC","Membrane, Cytoplasm","Matches in gapped BLAST to PTS system, enzyme IIC. Residues 13-272 are 61% similar to >gi15900217 in S.pneumoniae and 58% similar to gi15675588 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0360 (2e-84).","

InterPro
IPR002016
Family

Haem peroxidase, plant/fungal/bacterial
PS00435	$\"[35-45]?$	PEROXIDASE_1

InterPro
IPR004700
Family

Phosphotransferase system, sorbose-specific IIC subunit
PF03609	$\"[1-241]T$	EII-Sor
PS51106	$\"[1-238]T$	PTS_EIIC_TYPE_4

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 130-244 are 50% similar to a (COMPONENT IIC SYSTEM PHOSPHOTRANSFERASE) protein domain (PD010825) which is seen in Q9S4L4_STRSL.Residues 13-113 are 72% similar to a (COMPONENT IIC SYSTEM PHOSPHOTRANSFERASE) protein domain (PD009389) which is seen in Q9S4L4_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 18:55:00 2006","Wed Aug 23 16:47:49 2006","Wed Aug 23 16:47:49 2006","Fri Mar 8 16:21:02 2002","","Fri Mar 8 16:21:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1708 is paralogously related (blast p-value < 1e-3) to SMu0090, a predicted sorbose PTS system, IIC component, and to SMu1778, a possible PTS system fructose-specific enzyme IIC component.","Fri Mar 8 16:31:14 2002","","No significant hits to the NCBI PDB database.","SMU.1878","","Residues 1 to 241 (E-value = 3.9e-120) place SMu1708 in the EII-Sor family which is described as PTS system sorbose-specific iic component (PF03609)","Fri Mar 8 16:21:02 2002","24380234","","","Lortie,L.A., Pelletier,M., Vadeboncoeur,C. and Frenette,M.The gene encoding IIAB(Man)L in Streptococcus salivarius is part of a tetracistronic operon encoding a phosphoenolpyruvate:mannose/glucose phosphotransferase systemMicrobiology 146 (Pt 3), 677-685 (2000)PubMed: 10746771","","Thu Apr 11 10:59:43 2002","1","","","SMU.1878","527" "SMu1709","1772191","1773117","927","ATGTCAGAAAGAATTCAACTATCAAAATCTGATCGTCATAAAGTATGGTGGCGTTCAACCTTCCTGCAAGGTTCTTGGAACTATGAACGGATGCAAAATTTAGGTTGGGCATATGCTTTGATTCCAGCTATCAAAAAACTTTATACAAACAAAGAAGATCGTGCTGCCGCCCTTGAGCGTCATTTGGAATTTTTCAATACTCATCCATATATTGCTGCTCCTATCTTAGGAGTAACACTTGCTTTGGAAGAAGAGAAATCAAACGGTACCAAAGTGGATGATGCTGCTATTCAGGGAATTAAAATCGGTATGATGGGACCATTAGCCGGTATCGGAGATCCCGTTTTCTGGTTTGTTCTTCGCCCAACACTAGGTGCCCTTGGGGCTTCTCTTGCAATATCAGGAAACATCCTAGGACCAATCATCTTCTTCTTTGCTTGGAACATTATCCGTATGGCTTTCTTATGGTATACACAAGAGTTTGGCTATAAAGCAGGGACAGAAATTACTAAAGATCTCTCAGGAGGGATTCTCAAAAATATTACTAAGGGGGCTTCAATCCTCGGTATGTTTGTTATTGGGGCACTTGTTCAGCGTTGGGTAACGATTAATTTCGCGCTGAAACTCCCATCAACTAAATTAACGAATGATAATGGAGCCACTTATATACAATTCCCCAAAGACAGCGAAGTTATTCATAGTGGTCAGCTTCAAAAGATACTTCAAGGTGTTAAAGATAATTTAAGCTTAACAAATGTAAAAGTGGAAACTTTACAAGATCAATTGGATAAATTACTTCCAGGTTTGATGGCTCTTCTACTTACACTTCTTTGTATGTGGTTGCTTAAGAAAAAAGTTTCTCCAATTGTAATGATTCTTGGACTGTTCGTTGTAGGTATTATTGCTCACGTCATTGGATTGATGTAA","10.20","9.15","34218","MSERIQLSKSDRHKVWWRSTFLQGSWNYERMQNLGWAYALIPAIKKLYTNKEDRAAALERHLEFFNTHPYIAAPILGVTLALEEEKSNGTKVDDAAIQGIKIGMMGPLAGIGDPVFWFVLRPTLGALGASLAISGNILGPIIFFFAWNIIRMAFLWYTQEFGYKAGTEITKDLSGGILKNITKGASILGMFVIGALVQRWVTINFALKLPSTKLTNDNGATYIQFPKDSEVIHSGQLQKILQGVKDNLSLTNVKVETLQDQLDKLLPGLMALLLTLLCMWLLKKKVSPIVMILGLFVVGIIAHVIGLM","1773127","For other 'ptn' genes see SMu1708 (ptnC) and SMu1709 (ptnD).","mannose PTS system component IID","Membrane, Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0359 (1e-115).","

InterPro
IPR004704
Family

Phosphotransferase system, mannose/fructose/sorbose family IID component
PF03613	$\"[5-308]T$	EIID-AGA
TIGR00828	$\"[5-308]T$	EIID-AGA
PS51108	$\"[5-308]T$	PTS_EIID

noIPR
unintegrated

unintegrated
SSF82866	$\"[203-307]T$	SSF82866

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-203 are 82% similar to a (COMPONENT IID SYSTEM PHOSPHOTRANSFERASE) protein domain (PD013894) which is seen in Q9S4L3_STRSL.Residues 222-308 are 36% similar to a (IID SYSTEM MANNOSE-SPECIFIC COMPONENT) protein domain (PD242695) which is seen in Q9S4L3_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 6 18:44:01 2006","Wed Sep 6 18:21:20 2006","Wed Sep 6 18:44:01 2006","Fri Mar 8 16:39:43 2002","","Fri Mar 8 16:39:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1709 is paralogously related (blast p-value < 1e-3) to SMu1777, a predicted PTS system fructose-specific enzyme IID component and SMu0091, a predicted PTS system, IID component.","Mon Apr 15 16:31:21 2002","","No significant hits to the NCBI PDB database.","SMU.1879","","Residues 5 to 308 (E-value = 4.1e-188) place SMu1709 in the EIID-AGA family which is described as PTS system mannose/fructose/sorbose family IID component (PF03613)","Fri Mar 8 16:39:43 2002","24380235","","","","","","1","","","SMU.1879","269" "SMu1710","1775740","1773449","2292","ATGAACATATTTTCTTATCTTCTTTTGACTGTAGTTTCAGTATTATTAGTCAATTTATTCTTAGAATTTATAAAATACTTTTTTAAAACAACTCCAGCAATGAATAAGGAAAATTCTAAGAAATCTTCAATTTTTTTGTGGAGTCGAACTAGACGTTTTAAATTTGTACCACAAGTCGATAATAGAGACTGTGGCCCGGCTGCTCTAGCCTCTATTGCCAAACATTATGGTTCATATTATTCCTTGGTTCATCTGCGTGAACTTACAAAGACAGATCGACAAGGCACCACAGCATTAGGCATCATTGAAGCTGCCAAAAATATTGGATTTGAAACTTACTCGCTAGATGCTGATATGTCTTTATTTAATTATGATGACCTTATTTACCCTTTTATTGTTCACGTTGTTAAAAATAAACGTCTTCAACATTACTATGTTGTTTATGACGATGAAGGAGATAGTCTAATCATCGGAGATCCAGATCCTTCTGTCAAAGTTATTCGCATGTCTAAGGAGAGATTTCAGCATGAATGGACAGGTGTAGCTATCTTCTTTTCCCCAAAGGATGATTATCAGCCTCAAAAAGATAAAAGAAGAGGATTAACAAGTTTCATACCTTCTTTTTTAAAGCAAAAGAGTCTCTTGTTCTATATTATAATGGCGAGTTTAATCATTACTTTAATAGAAATTATTGGAGCTTTTTATCTCCAAGTAATGCTGGATGAGTATATTCCCAGTCAAAAAATTTCAACTTTAGGCTTTATCACTTTAGGATTAATAATAACTTATGTTGCCCAACAAATAATAGCTTTTGCAAAAGAGTACTTATTAATTATATTAGGACAAAGGCTGGTAATTGATGTTATACTTACTTATATTAAGCACATTTTTATTCTTCCGATGTCTTTTTTTTCGACAAGACGAACGGGAGAAATCACATCTCGCTTCACTGATGCCAATCAAATTATTGATGCTGTGGCGTCAACAATTTTTTCTATTTTCTTAGACATTTCGATGGTATTTATAGTTGGTGGAGTATTATTAATTCAAAATGTCGTTTTATTTTTCCTAGCCTTGCTCTGCGTTCCTATCTACATTATCATTGTTTTTGCATTTATGAAAATGTTTGGTTACTTAAACTATGAGGTAATGGAAAGTAATGCGATAATGTCTTCATCTGTTATTGAGGATATTAATGGAATAGAAACTATCAAATCTTTGACGAGTGAAGAAGTTAGCTATCAGAGAATTGACAAGGAATTTGTTGATTTTTTAGAGAAATCTTTTAGGCTGCATAAGTATGGAGCTATTCAAGTCTCAATTAAAACTGCTGCAAAGCTAATTTTGAATATCGTTATTCTATGGTATGGAGCACGATTGGTTATGACCGGGAAAATTTCAGTGGGTCAAATGATTGCTTTTAATGTGCTTTTAGGATATTTTTCAAGCCCAATTGAAAATATGATTAATTTACAAATTAAGCTCCAATCAGCCCGCATAGCTAATACGCGTCTCAATGAAGTCTATCTGGTCGATTCTGAGTTTGAAAATAATGGGGAGCTTTCAGAAGGCAGCTTTTTGGATGGGGATATCTCTTTTGAAAAGTTATCTTACAAGTATGGTTATGGTCGTGATACTCTGTCAGATATCAATCTAACTATTAAAAAAGGTTCAAAGGTCAGTCTGGTCGGAGCCTCTGGTTCTGGTAAAACGACTCTTGCCAAGATGATTGTCAATTTTTATGAACCTATACAGGGTCTTATCCGTCTTAATGGCTATGACCTAAAAGATATAGATAAGACTGTTTTACGCCAGCATATTAACTATCTCCCCCAACAAGCTTATGTCTTTAGTGGTACCATTATGGATAATCTGACCTTGGGAGCCAAGGAAGACACTATTCAGGAAGATATTATTCGAGCCTGTGAAATTGCTGAGATTCATTCAGACATTGAACAAATGCCGCTGGGGTACCAGACTGAGTTATCTGATAGTACTGGAGTTTCCGGTGGCCAGAAGCAGCGGATTGCCTTGGCTCGCGCTCTCTTAACCCAAGCTCCAGTTTTGATTTTGGATGAAGCCACCAGCAGTCTGGATGTCCTGACTGAAAAGAAAATCGTCAACAACCTCATGGCCATGACCAATAAGACTATTGTTTTTGTGGCACACCGTTTGAGTATTGCTCAACGGACAGACCGAATTATTGTTATGGATCAAGGTAAGATTGTGGAAGAAGGTAGCCATAAGGAACTTTTAGCTCATAAAGGCTTCTACTACAAGCTGTTTAACTAA","7.20","0.80","86445","MNIFSYLLLTVVSVLLVNLFLEFIKYFFKTTPAMNKENSKKSSIFLWSRTRRFKFVPQVDNRDCGPAALASIAKHYGSYYSLVHLRELTKTDRQGTTALGIIEAAKNIGFETYSLDADMSLFNYDDLIYPFIVHVVKNKRLQHYYVVYDDEGDSLIIGDPDPSVKVIRMSKERFQHEWTGVAIFFSPKDDYQPQKDKRRGLTSFIPSFLKQKSLLFYIIMASLIITLIEIIGAFYLQVMLDEYIPSQKISTLGFITLGLIITYVAQQIIAFAKEYLLIILGQRLVIDVILTYIKHIFILPMSFFSTRRTGEITSRFTDANQIIDAVASTIFSIFLDISMVFIVGGVLLIQNVVLFFLALLCVPIYIIIVFAFMKMFGYLNYEVMESNAIMSSSVIEDINGIETIKSLTSEEVSYQRIDKEFVDFLEKSFRLHKYGAIQVSIKTAAKLILNIVILWYGARLVMTGKISVGQMIAFNVLLGYFSSPIENMINLQIKLQSARIANTRLNEVYLVDSEFENNGELSEGSFLDGDISFEKLSYKYGYGRDTLSDINLTIKKGSKVSLVGASGSGKTTLAKMIVNFYEPIQGLIRLNGYDLKDIDKTVLRQHINYLPQQAYVFSGTIMDNLTLGAKEDTIQEDIIRACEIAEIHSDIEQMPLGYQTELSDSTGVSGGQKQRIALARALLTQAPVLILDEATSSLDVLTEKKIVNNLMAMTNKTIVFVAHRLSIAQRTDRIIVMDQGKIVEEGSHKELLAHKGFYYKLFN","1773465","SMu1710 has a NBD1.For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0451 (comF);SMu0452 (comFC); SMu0490 (comC);SMu1782 (comA);SMu1684 (comEB); SMu1739 (comC) and SMu1740 (comD).","competence factor transporting ATP-binding / permease protein","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to ComA-related ABC transporters. Residues 57-763 are 62% similar to gi|15902087 from S.pneumoniae. Residues 51-763 are 56% similar to gi|703126, a predicted leucocin A translocator from Leuconostoc gelidum.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (1e-66).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[215-485]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[669-710]T$	ABC_transporter
PF00005	$\"[557-740]T$	ABC_tran
PS00211	$\"[668-682]T$	ABC_TRANSPORTER_1
PS50893	$\"[531-763]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[556-741]T$	AAA

InterPro
IPR005074
Domain

Peptidase C39, bacteriocin processing
PF03412	$\"[56-190]T$	Peptidase_C39
PS50990	$\"[58-185]T$	PEPTIDASE_C39

InterPro
IPR005897
Family

Peptidase C39, ABC-type bacteriocin transporter
TIGR01193	$\"[58-763]T$	bacteriocin_ABC

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[218-497]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[496-762]T$	G3DSA:3.40.50.300
PIRSF002787	$\"[55-763]T$	Hemolysin_sec_B
PTHR19242	$\"[191-763]T$	PTHR19242
PTHR19242:SF91	$\"[191-763]T$	PTHR19242:SF91
SSF52540	$\"[531-763]T$	SSF52540
SSF90123	$\"[193-514]T$	SSF90123

","BeTs to 12 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.2e-63. IPB001140A 546-592 IPB001140B 665-703 IPB001140C 717-746","Residues 715-744 are 76% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER P-GLYCOPROTEIN) protein domain (PD000383) which is seen in Q9EW69_STRPN.Residues 191-247 are 45% similar to a (ATP-BINDING TRANSPORT COMPETENCE COMA) protein domain (PD155322) which is seen in COMA_STRPN.Residues 85-207 are 63% similar to a (TRANSPORT ATP-BINDING COMPLETE PROTEOME) protein domain (PD003456) which is seen in Q9ETN5_STRPN.Residues 562-742 are 24% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD316735) which is seen in Q9PPY0_UREPA.Residues 598-663 are 72% similar to a (TRANSPORT ATP-BINDING LACTOCOCCIN) protein domain (PD402967) which is seen in COMA_STRPN.Residues 354-461 are 62% similar to a (ATP-BINDING TRANSPORT TRANSPORTER) protein domain (PD331886) which is seen in Q9EW68_STRPN.Residues 599-665 are 47% similar to a (TRANSPORTER SUBLANCIN ATP-BINDING) protein domain (PD336499) which is seen in Q9XDS0_BBBBB.Residues 547-682 are 26% similar to a (ABC TRANSPORTER) protein domain (PD241124) which is seen in Q9U0N4_PLAF7.Residues 597-664 are 67% similar to a (TRANSPORT ATP-BINDING ABC TRANSPORTER) protein domain (PD306522) which is seen in Q9EW69_STRPN.Residues 607-664 are 44% similar to a (ATP-BINDING TRANSPORT COMPLETE ABC) protein domain (PD333091) which is seen in Q9ZI23_STRSL.Residues 552-755 are 26% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 668-716 are 55% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459) which is seen in MDR1_LEIEN.Residues 600-665 are 66% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME) protein domain (PD285760) which is seen in Q48553_LEUGE.Residues 224-335 are 65% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC TRANSMEMBRANE) protein domain (PD087348) which is seen in Q9CJB8_LACLA.Residues 462-545 are 58% similar to a (ATP-BINDING TRANSPORT TRANSPORTER ABC COMPLETE PROTEOME) protein domain (PD149818) which is seen in COMA_STRPN.Residues 215-540 are 20% similar to a (LTKB HOMOLOG) protein domain (PD168585) which is seen in O85327_SALTY.Residues 547-595 are 71% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in COMA_STRPN.Residues 668-710 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9EW69_STRPN.Residues 208-540 are 21% similar to a (TRANSPORT ATP-BINDING 481/LACTOCOCCIN) protein domain (PD102152) which is seen in Q9F445_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:26:47 2002","Mon Oct 28 11:26:47 2002","Tue Oct 15 15:44:45 2002","Thu Apr 4 10:15:09 2002","Sat Mar 9 13:05:54 2002","Sat Mar 9 13:05:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1710 is paralogously related (blast p-value < 1e-3) to SMu0258, SMu1724, SMu0825, SMu0837, SMu0986, SMu0476, SMu0836, SMu0824, SMu1065, SMu1064, SMu0024, SMu0475, SMu1723, SMu0987, SMu1920, SMu1003, SMu0218, SMu0971, SMu1517, SMu0517, SMu0418, SMu1950, SMu0916, SMu0390, SMu1757, SMu1380, SMu1762, SMu0849, SMu0731, SMu0786, SMu1036, SMu0884, SMu0235, SMu1001, SMu0950, SMu1949, SMu1068, SMu0594, SMu1210, SMu1545, SMu1751, SMu1246, SMu1231, SMu1518, SMu1079, SMu1037, SMu0976, SMu0907, SMu0234, SMu1288, SMu1023, SMu0805, SMu1093, SMu1316, SMu0823, SMu1649, SMu0944, SMu0335, SMu1428, SMu0374, SMu0752, SMu0216, SMu1410, SMu1725, SMu0596, SMu1959, SMu0224, SMu0164, SMu1811, SMu0729, SMu1306, SMu1050, SMu0666, and SMu1686, all ATP-binding proteins.","Sat Mar 9 13:10:26 2002","Sat Mar 9 13:05:54 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 89 1e-018pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 76 2e-014","SMU.1881c","","Residues 56 to 190 (E-value = 6e-60) place SMu1710 in the Peptidase_C39 family which is described as Peptidase C39 family (PF03412)Residues 215 to 485 (E-value = 7.2e-57) place SMu1710 in the ABC_membrane family which is described as ABC transporter transmembrane region (PF00664)Residues 557 to 740 (E-value = 1.5e-56) place SMu1710 in the ABC_tran family which is described as ABC transporter (PF00005)","Sat Mar 9 13:05:54 2002","24380236","","","Hui,F.M. and Morrison,D.A.Genetic transformation in Streptococcus pneumoniae: nucleotidesequence analysis shows comA, a gene required for competenceinduction, to be a member of the bacterial ATP-dependent transportprotein familyJ. Bacteriol. 173 (1), 372-381 (1991)PubMed: 1987129","Mon Oct 28 11:26:26 2002","Thu Apr 4 10:15:09 2002","1","","","SMU.1881c","" "SMu1711","1776643","1776290","354","ATGAAATGTCAAGCGTTTGAAGATTTTAAAGCTACAAGTTTGAATAAGCTGTCTTATACGACAGGTGGAGCTACTGATGGTGAAATTATAGCTAATCGGATGTTACAAGGTAAAGCTACTAAGGGCGAAATTACTATGTATACTTGGAACATTATTCAAAATGGCTGGGTGAATTCACTCGTGTCTTGGGGTATTGGTGGTTATAATAGTTCTATAGGATACTCAGCTCAAGGTAATAGAGGATTTAGTAATTATCCATACGATGTTTCTATGGATTCAGATAATAGCAGTAGTTCAAGTAATACGACAGGTGGTTATGTTAATTATAACCAGAGTTTTAATTCTGGATGGTAA","4.90","-1.07","12719","MKCQAFEDFKATSLNKLSYTTGGATDGEIIANRMLQGKATKGEITMYTWNIIQNGWVNSLVSWGIGGYNSSIGYSAQGNRGFSNYPYDVSMDSDNSSSSSNTTGGYVNYNQSFNSGW","1776306","","hypothetical protein","Extracellular","No significant hits in gapped BLAST.SMu1711 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Mar 9 13:11:41 2002","Sat Mar 9 13:11:41 2002","Sat Mar 9 13:11:41 2002","Sat Mar 9 13:11:41 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1711 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sat Mar 9 13:11:41 2002","","No significant hits to the NCBI PDB database.","SMU.1882c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 13:11:41 2002","24380237","","","","","","1","","","SMU.1882c","" "SMu1712","1776962","1777330","369","ATGGCACAGTCAATTAATACAAAAGTTGAATACACAGGCAAAGGTGTATCATATTTAGGCGTAGGTGGCAAAGTGGGAAAATTTCTTCTTGGCGATCGTAGCTTTGAATTCTATAATGATGCTAATGTGGAACATTTTATCCAAATTCCTTGGTCTAGTATTATTGAAATAGGAGCCAATGTCAATCGGAAAAAGGTCAGCAGACACTTTGAAATTATTACGGACAAAGGAAAATTCCTCTTTGCCTCATCTGATTCTGGTAAAATTCTAAAAATTGCAAGACAGCATGTTGGTAATGATAAAGTGGTTCGCTACCCTAGTTTACTTCAAAAGATTGCCAGCTTCTTTAAACGAAAAAAGAAGGGTTAG","10.90","12.70","13708","MAQSINTKVEYTGKGVSYLGVGGKVGKFLLGDRSFEFYNDANVEHFIQIPWSSIIEIGANVNRKKVSRHFEIITDKGKFLFASSDSGKILKIARQHVGNDKVVRYPSLLQKIASFFKRKKKG","1777340","","conserved hypothetical protein","Cytoplasm","Limited matches in gapped BLAST to conserved hypothetical proteins. Residues 1-118 are 60% similar to gi|15675590 from S.pyogenes. Residues 1-117 are 57% similar to gi|5669858 from S.salivarius.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0358 (1e-36).","

InterPro
IPR010360
Family

Protein of unknown function DUF956
PF06115	$\"[1-122]T$	DUF956

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-109 are 57% similar to a (PROTEOME COMPLETE YRGE YRGG) protein domain (PD293752) which is seen in Q9S4L2_STRSL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:34:25 2002","Sat Mar 9 13:14:27 2002","Tue Oct 8 15:34:25 2002","Sat Mar 9 13:14:27 2002","","Sat Mar 9 13:14:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1712 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:34:25 2002","","No significant hits to the NCBI PDB database.","SMU.1883","","Residues 1 to 122 (E-value = 9.3e-85) place SMu1712 in the DUF956 family which is described as Domain of unknown function (DUF956) (PF06115)","Sat Mar 9 13:14:27 2002","24380238","","","","","","1","","","SMU.1883","762" "SMu1713","1778640","1777567","1074","ATGAATAAGAAGAATGAAAAAATAAAAAGTTTACCATATAATGCTGGAATAGATTTCTTACGTATTTTTGCCATGTTTATGATTGTGGTGACGCATGTTTTGGGGAAAGGCGGCATTCGCTCAACTGTAAAAGAGAATTTTGACCTTTATTATTTTGTGACATGGGGAATTCAAGTATCTGCCTATAGTGCGGTTAATTGCTATGCTTTGATTAGTGGTTACGTTGGTGTTGATTCACCTTATCGTTATTCAAAATGTCTCTCATTGTGGTTACAGGTCTTCTTCTATACTTTATTATTTATCTTATTTTTTACTTTTTTGCAAAAGCCTATAACATACCATGATTGGATACAGGCTTTCTTCCCTATTATCACAGGTCAATATTGGTATGTAACAGCTTATTTTGGACTCTTGATTTTTATGCCTATTTTGAATCTAGCTTTAAGAAAGTTGAATACTAAAGATTTGAAACATATTGTCCTTTTAGCGATTATCTTCTTTTCTGTTCTTCCTGCATTATTGAATACCAAAGTAGATGAATTTTCATTTGCTAAGGGTTTTAGTATGAACTGGTTGAGTGTACTGTACATTATTGGAGCTTATTTGAAGCGGCTTGACTTAAAGCGTTTATTCAGTCGTAAATTTTTACTTTTTCTGTGTTTAATGGCAATGGCAGTGACTTTTATAACCAAAGTATTTATTGGAGATATCTGGTACTGGTATACCTCTCCCACTCTTCTTTGTGAGGCAGTGACTATTTTTATCTTTTTTGTCACTTTAGATATTAAAAAGACTGGTAGATTGTTTAGAATAATTAAACGAATGGCGCCGGCAACATTAGGAGTTTATCTTTTTCATCTAAATCCCCTTTTGGTTAAATTTCTTTTAAAAGATGGTTTTGAGTCATTTGTGACTGCTCCTATATGGCTTTTTCCTTTTTTGATTTTAGGGATGGCGCTCCTTATTTATCTCATTTCGACTCTAGTTGAGCTTTTACGGATAAAACTTTTTACTTATCTTAAGGTCAGACACCTTATTCTTAAATTGGATACTTATCTGCCGTTTGACAATTAA","10.50","20.00","41726","MNKKNEKIKSLPYNAGIDFLRIFAMFMIVVTHVLGKGGIRSTVKENFDLYYFVTWGIQVSAYSAVNCYALISGYVGVDSPYRYSKCLSLWLQVFFYTLLFILFFTFLQKPITYHDWIQAFFPIITGQYWYVTAYFGLLIFMPILNLALRKLNTKDLKHIVLLAIIFFSVLPALLNTKVDEFSFAKGFSMNWLSVLYIIGAYLKRLDLKRLFSRKFLLFLCLMAMAVTFITKVFIGDIWYWYTSPTLLCEAVTIFIFFVTLDIKKTGRLFRIIKRMAPATLGVYLFHLNPLLVKFLLKDGFESFVTAPIWLFPFLILGMALLIYLISTLVELLRIKLFTYLKVRHLILKLDTYLPFDN","1777583","","conserved hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0357 (3e-94).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[15-35]?$ $\"[49-71]?$ $\"[86-106]?$ $\"[128-148]?$ $\"[158-176]?$ $\"[182-200]?$ $\"[215-235]?$ $\"[239-259]?$ $\"[274-292]?$ $\"[306-326]?$	transmembrane_regions

InterPro
IPR002314
Domain

tRNA synthetase, class II (G, H, P and S)
PF00587	$\"[173-343]T$	tRNA-synt_2b

InterPro
IPR002317
Family

Seryl-tRNA synthetase, class IIa
PR00981	$\"[263-275]T$ $\"[275-288]T$ $\"[315-328]T$ $\"[332-348]T$ $\"[350-366]T$	TRNASYNTHSER
PTHR11778	$\"[100-424]T$	tRNA-synt_ser
PF02403	$\"[1-108]T$	Seryl_tRNA_N
TIGR00414	$\"[1-416]T$	serS

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[172-409]T$	AA_TRNA_LIGASE_II

InterPro
IPR010978
Domain

tRNA-binding arm
SSF46589	$\"[1-113]T$	tRNA_binding_arm

noIPR
unintegrated

unintegrated
G3DSA:1.10.287.40	$\"[1-105]T$	G3DSA:1.10.287.40
G3DSA:3.30.930.10	$\"[106-425]T$	G3DSA:3.30.930.10
SSF55681	$\"[115-425]T$	SSF55681

","BeTs to 17 clades of COG0172COG name: Seryl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0172 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003364 (Seryl-tRNA synthetase N-terminal domain) with a combined E-value of 1.7e-164. IPB003364A 1-10 IPB003364B 104-128 IPB003364C 140-177 IPB003364D 189-220 IPB003364E 223-250 IPB003364F 259-284 IPB003364G 330-367 IPB003364H 377-404 IPB003364I 408-417","Residues 1-90 are 34% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD263014) which is seen in Q9PIB3_CAMJE.Residues 104-417 are 84% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD003933) which is seen in Q9CEX2_LACLA.Residues 220-341 are 29% similar to a (SYNTHETASE LIGASE ATP-BINDING SERYL-TRNA) protein domain (PD023780) which is seen in SYS_METJA.Residues 1-97 are 60% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD058075) which is seen in Q9CEX2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 15:42:55 2002","Sat Mar 9 13:19:11 2002","Tue Oct 15 15:42:55 2002","Wed Apr 10 14:48:29 2002","Sat Mar 9 13:19:11 2002","Sat Mar 9 13:19:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1714 is paralogously related (blast p-value < 1e-3) to SMu1623, a predicted prolyl-tRNA synthetase, and to SMu1441, a predicted threonyl-tRNA synthetase.","Sat Mar 9 13:30:57 2002","Sat Mar 9 13:19:11 2002","pdb|1SES|A Chain A, Seryl-Trna Synthetase (E.C.6.1.1.11) (Serin... 259 3e-070","SMU.1886","","Residues 1 to 108 (E-value = 1.1e-45) place SMu1714 in the Seryl_tRNA_N family which is described as Seryl-tRNA synthetase N-terminal domain (PF02403)Residues 162 to 316 (E-value = 1.2e-61) place SMu1714 in the tRNA-synt_2b family which is described as tRNA synthetase class II core domain (G, H, P, S and T) (PF00587)","Sat Mar 9 13:19:11 2002","24380240","","","Stefanska AL, Fulston M, Houge-Frydrych CS, Jones JJ, Warr SR.A potent seryl tRNA synthetase inhibitor SB-217452 isolated from a Streptomyces species.J Antibiot (Tokyo). 2000 Dec;53(12):1346-53.PMID: 11217799 ","","Sat Mar 9 13:29:29 2002","1","","","SMU.1886","46" "SMu1715","1780765","1780971","207","ATGAAACCCACCTTTAAAAGTATTGACCAGCTAAAATCAGCTATTACAGATTATATTATTTATACTCTTCAAACTAGGTCAGCTTCACCTTGCCCTGCCTTAGCACTGCCCGTAGCTAGCTTCCTAGTTTGCTTTTTGATTTTCATTGAGTATTACTGCAGTAACAAACAAATCAAGACAAAATTAAAAGGACTGAGTCCTGTCTAA","9.90","4.83","7602","MKPTFKSIDQLKSAITDYIIYTLQTRSASPCPALALPVASFLVCFLIFIEYYCSNKQIKTKLKGLSPV","1780981","","transposase fragment","Membrane, Periplasm","Sub-threshold similarities in gapped BLAST to transposase fragments.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (7e-05).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[33-53]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[36-56]?$ $\"[62-84]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Mar 9 13:49:14 2002","Sat Mar 9 13:47:20 2002","Sat Oct 26 16:35:19 2002","Sat Mar 9 13:47:20 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1716 is paralogously related (blast p-value < 1e-3) to SMu1722, SMu0384, SMu1738, SMu1731, SMu0133, SMu0558, and SMu0255, all hypothetical proteins, some with relationships to bacteriocins.","Sat Mar 9 13:49:14 2002","","No significant hits to the NCBI PDB database.","SMU.1889c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 13:47:20 2002","24380242","","Bekal-Si Ali S, Hurtubise Y, Lavoie MC, LaPointe G. Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes.Gene. 2002 Jan 23;283(1-2):125-31.PMID: 11867219 ","","Sat Oct 26 16:35:19 2002","","1","","15","SMU.1889c","" "SMu1717","1781749","1781567","183","ATGCTCGCTGGTTTCGAAGATCTTGGCGCGGTTCAGGCTCATCCAGCCGTTTTTAAGACAGAAAACTTTGCTAATAAAAATCTGAGTTGCTGTAATGTTACTATTTTTCTGGAATATAATAAGCAGTATCATGCCAAAAAACTTGCTATTTTATGGTCTAATGCAGGAGTCATAAGCAGCTGA","8.10","1.36","6600","MLAGFEDLGAVQAHPAVFKTENFANKNLSCCNVTIFLEYNKQYHAKKLAILWSNAGVISS","1781583","","hypothetical protein","Extracellular","No significant matches in gapped BLAST.SMu1717 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:30:40 2002","Sat Mar 9 13:50:25 2002","Tue Oct 8 15:30:40 2002","Sat Mar 9 13:50:25 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1717 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:30:40 2002","","No significant hits to the NCBI PDB database.","SMU.1891c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 13:50:25 2002","24380243","","","","","","1","","15","SMU.1891c","" "SMu1718","1781879","1781694","186","ATGAAAACACAAACTGAAATCTGGAAACGATTTGAAGCATTAGATACAGCTGATCTAGCTATTATCCAAGGAGGAAGTGAGAACATAGCAAGATTTGCTGCTGCTTTTGAAAATGAACAAGTTGTAAGCTATGCTCGCTGGTTTCGAAGATCTTGGCGCGGTTCAGGCTCATCCAGCCGTTTTTAA","10.50","1.98","7014","MKTQTEIWKRFEALDTADLAIIQGGSENIARFAAAFENEQVVSYARWFRRSWRGSGSSSRF","1781710","","hypothetical protein","Extracellular, Periplasm","No significant hits in gapped BLAST.SMu1718 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:30:17 2002","Sat Mar 9 13:51:29 2002","Tue Oct 8 15:30:17 2002","Sat Mar 9 13:51:29 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1718 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:30:17 2002","","No significant hits to the NCBI PDB database.","SMU.1892c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 13:51:29 2002","24380244","","","","","","1","","15","SMU.1892c","" "SMu1719","1782835","1781999","837","TTGGTAACGGAGTTTTCTTTAGACATTCTTCTAAAGATTATTAAGCTCGCTCGTTCAACCTATTATTACCACTTAAAGCAGCTAGATAAAAGCAATAAAGATCATGCTATTAAAGCTGAAATTCAAGCTATTTTTACTGAGCACAAAGGAAATTATGGTTATCGTCGAATGACTCTTGAATTGAGAAATCGTGGCTTCTTGGTAAATCATAAAAAGGTTCAACGTCTAATGAAAGTTCTTGGTTTGGAGGCTCGTATTCGTCGCAAACGGAAGTATTCTTCCTACCAAGGAGAGGTGGGCAAGAAAGCAGACAACCTTATTCAACGCCAATTTGAAGCATCAAAACCAATGGAAAAGTGCTACACAGATGTGACAGAATTTGCCATTCCAGCAAGCGGTCAAAAGCTCTATTTGTCACCAGTTTTAGATGGTTTCAACAGTGAAATTATTGCTTATAACCTTTCTACGTCACCGAACTTGATACAAGTGAAAGCTATGCTAGAACAGGCTTTCACAGAGAAACATTACACAAATACTATTCTTCATAGTGACCAAGGCTGGCAATACCAGCATGATTTTTATCATCAATTTTTAGAGAACAAGGGGATTCAGCCGTCCATGTCACGTAAAGGAAACAGCCCAGATAATGGCATGATGGAATCTTTCTTTGGCATTTTGAAATCCGAAATGTTTTACGGTTATGAGAAGACATTTAAGTCACTTAAGCAATTGGAACAAGCTATTGTAGACTATATTGATTATTACAACAACAAACGTATTAAGGTAAAACTAAAAGGACTTAGTCCTGTACAGTACAGAACGAAATCCTTTACTTAA","10.40","17.88","32568","MVTEFSLDILLKIIKLARSTYYYHLKQLDKSNKDHAIKAEIQAIFTEHKGNYGYRRMTLELRNRGFLVNHKKVQRLMKVLGLEARIRRKRKYSSYQGEVGKKADNLIQRQFEASKPMEKCYTDVTEFAIPASGQKLYLSPVLDGFNSEIIAYNLSTSPNLIQVKAMLEQAFTEKHYTNTILHSDQGWQYQHDFYHQFLENKGIQPSMSRKGNSPDNGMMESFFGILKSEMFYGYEKTFKSLKQLEQAIVDYIDYYNNKRIKVKLKGLSPVQYRTKSFT","1782015","","IS3-Spn1 transposase (IS861)","Cytoplasm","Similarities in gapped BLAST to IS3-Spn1 transposases. Residues 2-277 are 84% similar to >gi8163693 from S.pneumoniae. Residues 5-278 are 76% similar to >gi97890 from S.agalactiae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1527 (1e-122).","

InterPro
IPR001584
Domain

Integrase, catalytic core
PF00665	$\"[112-274]T$	rve
PS50994	$\"[112-277]T$	INTEGRASE

noIPR
unintegrated

unintegrated
PD688335	$\"[35-76]T$	Q8DVC7_STRMU_Q8DVC7;
G3DSA:3.30.420.10	$\"[137-278]T$	no description
signalp	$\"[1-19]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 231-273 are 51% similar to a (ELEMENT ORFB B. CRYIIB) protein domain (PD410106) which is seen in Q57057_BACAN.Residues 163-203 are 82% similar to a (TRANSPOSASE ELEMENT COMPLETE) protein domain (PD335900) which is seen in Q9KK23_STRPN.Residues 122-162 are 95% similar to a (TRANSPOSASE ELEMENT INSERTION COMPLETE) protein domain (PD006527) which is seen in Q9KK23_STRPN.Residues 12-150 are 27% similar to a (TRANSPOSASE) protein domain (PD102854) which is seen in Q48525_LACCA.Residues 59-119 are 73% similar to a (TRANSPOSASE COMPLETE ELEMENT OF) protein domain (PD245714) which is seen in Q9KK23_STRPN.Residues 206-273 are 95% similar to a (TRANSPOSASE PROTEOME COMPLETE PLASMID) protein domain (PD004749) which is seen in Q9KK23_STRPN.Residues 206-256 are 86% similar to a (TRANSPOSASE PLASMID COMPLETE OF) protein domain (PD000334) which is seen in Q53640_STRAG.Residues 5-56 are 76% similar to a (TNIA ISTB TNIBDELTA1 COMPLETE) protein domain (PD402756) which is seen in Q9KK23_STRPN.Residues 125-198 are 41% similar to a (TRANSPOSASE OF PROTEOME COMPLETE) protein domain (PD395630) which is seen in O50351_LACHE.Residues 10-56 are 48% similar to a (TRANSPOSASE ELEMENT PROTEOME FOR) protein domain (PD195495) which is seen in INSK_ECOLI.","","Thu Nov 29 18:53:52 2001","Thu Nov 29 18:53:52 2001","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Mar 9 13:59:09 2002","Sat Mar 9 13:56:33 2002","Thu Aug 31 12:17:37 2006","Sat Mar 9 13:56:33 2002","","Sat Mar 9 13:56:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1719 is paralogously related (blast p-value < 1e-3) to SMu1283, SMu0695, SMu0395, SMu1258, SMu0514, SMu0798, SMu1250, SMu0934, SMu0537, SMu1237, SMu1236, and SMu1235, all transposases or transposase fragments.","Sat Mar 9 13:59:09 2002","","No significant hits to the NCBI PDB database.","SMU.1893c","Thu Nov 29 18:53:52 2001","Residues 112 to 274 (E-value = 1.2e-40) place SMu1719 in the rve family which is described as Integrase core domain (PF00665)","Sat Mar 9 13:56:33 2002","24380245","","","Rubens,C.E., Heggen,L.M. and Kuypers,J.M.IS861, a group B streptococcal insertion sequence related to IS150and IS3 of Escherichia coliJ. Bacteriol. 171 (10), 5531-5535 (1989)PubMed: 2477359","Thu Aug 31 12:17:37 2006","Sat Mar 9 13:56:33 2002","1","","15","SMU.1893c","588" "SMu1720","1783347","1782829","519","ATGAAATTGACTTATGAAGATAAAGTTCTCATCTATGAACTGAAAAACCAAGGGTATAGCTTAGAGCAGCTTTCAAATAAATTTGGGATAAAAATTTCTAATCTTAGCTACATGATTAAATTGATTGATCATTACGGAATAGAGATCGTCAAAAAAGGAAAGAATCGTTACTATTCTCCTGAACTAAAACAAGAAATCATTGATAAAGTTCTTCTTGAAGGTCGTTCACAAATAAGGGTGTCTCTAGATTATGCTCTTCCAAGTCATGGAATGTTGCCTAATTGGATAGCACAATACAAGAAAAATAGGTATACTATTGTTGAGAAAACAAGAGGGAGACCACCTAAAATGGGACGTAAGCCAAAGAAGAAATCGGAAGAAATGACAGAGCTAGAGCAACTTCAGAAAGAATTAGAATATCTGAGAGCGGAGAATGCTGTTCTAAAAAAGTTGAGAGAACTCCGATTGAGGGAAGAAAAAGAGCAAGAAGAAAAACGGAAATTGTCCGAGGATTGGTAA","10.40","10.49","20606","MKLTYEDKVLIYELKNQGYSLEQLSNKFGIKISNLSYMIKLIDHYGIEIVKKGKNRYYSPELKQEIIDKVLLEGRSQIRVSLDYALPSHGMLPNWIAQYKKNRYTIVEKTRGRPPKMGRKPKKKSEEMTELEQLQKELEYLRAENAVLKKLRELRLREEKEQEEKRKLSEDW","1782845","","transposase, IS861-associated","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins and to degenerate transposases. Residues 1-108 are 73% similar to gi8163692 from S.pneumoniae and 62% similar to gi15674401 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1526 (9e-37).","

InterPro
IPR002514
Family

Transposase IS3/IS911
PF01527	$\"[55-148]T$	Transposase_8

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[3-96]T$	Homeodomain_like

InterPro
IPR010133
Domain

Bacteriocin-type signal sequence
TIGR01847	$\"[9-23]T$	bacteriocin_sig: bacteriocin-type signal se

InterPro
IPR010133
Domain

Bacteriocin-type signal sequence
TIGR01847	$\"[26-40]T$	bacteriocin_sig: bacteriocin-type signal se

noIPR
unintegrated

unintegrated
tmhmm	$\"[53-73]?$ $\"[79-99]?$	transmembrane_regions

InterPro
IPR002035
Domain

von Willebrand factor, type A
PR00453	$\"[6-20]T$ $\"[105-113]T$	VWFADOMAIN

InterPro
IPR005074
Domain

Peptidase C39, bacteriocin processing
PF03412	$\"[29-152]T$	Peptidase_C39
PS50990	$\"[31-157]T$	PEPTIDASE_C39

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 58-139 are 71% similar to a (TRANSPORT ATP-BINDING COMPLETE PROTEOME) protein domain (PD003456) which is seen in Q9ETN5_STRPN.Residues 28-53 are 84% similar to a (TRANSPORT ATP-BINDING ABC TRANSMEMBRANE) protein domain (PD253434) which is seen in Q9ETN5_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Mar 9 14:18:52 2002","Sat Mar 9 14:16:12 2002","Tue Oct 15 15:37:57 2002","Sat Mar 9 14:16:12 2002","","Sat Mar 9 14:16:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1723 is paralogously related (blast p-value < 1e-3) to SMu0258, and SMu1710, both ABC transporter elements related to ComA.","Sat Mar 9 14:20:13 2002","","No significant hits to the NCBI PDB database.","SMU.1897","","Residues 29 to 152 (E-value = 4.1e-48) place SMu1723 in the Peptidase_C39 family which is described as Peptidase C39 family (PF03412)","Sat Mar 9 14:16:12 2002","24380249","","","","","","1","","15","SMU.1897","" "SMu1724","1784881","1786392","1512","ATGGCCAGTTTAATGGTGACACTGATTGATATCGCAGGTTCCTATTATCTACTAGGTATTCTGGATGAATATATCCCTAATCAGCTCATTTCAACACTGGGTATTATCTCTATTGGCTTAATTATCACCTATATCATCCAACAGATGATGGAGTTTGCCAAAGGTTACTTACTGGTGGTTCTAAGTCAGCGTCTTGTTATTGATGTTATCCTTTCTTATATTAGACACATCTTTACCCTGCCGATGTCTTTTTTTGCTACAAGAAGAACAGGGGAAATTACCTCACGTTTCTCTGATGCTAATTCCATTATTGATGCCGTGGCTTCAACCATTTTTTCTATCTTTTTGGATCTTACCATGCTTATTTTAGTCGGCAGTGTCCTATTGATACAAAATGGCAACCTTTTCCTGCTTACACTCATTTCGATTCCTATCTATGCAGTGATTATCTTTGTTTTCATGAAACCTTTTGAAAAAATGAATCAGGAAATCATGCAGAGCAATTCAATGGTTTCTTCTGCCATCATTGAAGATATCAATGGTATTGAAACCATTAAATCTTTAACCAGTGAAACTGCCCGTTATCAAAATATTGACAGTGAATTTGTGGATTATTTGGACAAATCTTTCAAACTCCATAAATATGAAACGCTGCAAACATCACTTAAAAAAGGGGCCCAATTGATTCTCAACGTTGTCATTTTGTGGTGCGGTGCTCAATTGGTTATGTCGGTCGGCCAGCTCATTACTTATAATTCTTTATTAACCTACTTTTCTAATCCTATTGAAAATATTATCAACCTGCAAACCAAACTGCAGTCTGCCAGAGTGGCTAATAATCGTTTAAATGAAGTTTATCTTGTCGAATCAGAATTTAACGATACTGGAACTTTATCAGACAGTGACTTCCTTGCTGGAGATATTACTTTTGAAGACTTATCTTATAAGTATGGTTTTGGAAGAGACACTTTATCAGATATTAATTTAAGGATCAAAAAAAATGATAAAGTCAGTATCGTTGGTGTCAGCGGATCTGGAAAGACCACTCTAGCGAAAATAATTGTTCATTTTTATGACCCTTATAAGGGACATATTCGAATTAATGGCAATGACTTAAAAACAATTGACAAAACCACTTTGCGGCAATATATCAATTATCTGCCGCAGCAGGCTTATATCTTTAGTGGAACTATCTTTGAAAATCTAACATTAGGAGCTAAAGAAGGCATTAGTCAAGCAGATGTTCTAAAGGCTTGTGAAATTGCTGAAATTCGCTCGGATATAGAACAAATGCCTATGGGCTATCAAACAGAACTCTCTGACGGAGCCGGTCTATCAGGCGGACAAAAACAGCGGGTTGCTTTAGCACGTGCACTTTTAACAAAGTCTCCTGTTTTAATTCTTGATGAAGCTACCAGCAGTCTTGATGTTCTTACTGAGAAAAAAATTATGGATAACCTGCTGCAGATGGCAGACAAGACTGTTGCTCAGTATCTCTCAGCGGACCGATAG","5.00","-9.10","56103","MASLMVTLIDIAGSYYLLGILDEYIPNQLISTLGIISIGLIITYIIQQMMEFAKGYLLVVLSQRLVIDVILSYIRHIFTLPMSFFATRRTGEITSRFSDANSIIDAVASTIFSIFLDLTMLILVGSVLLIQNGNLFLLTLISIPIYAVIIFVFMKPFEKMNQEIMQSNSMVSSAIIEDINGIETIKSLTSETARYQNIDSEFVDYLDKSFKLHKYETLQTSLKKGAQLILNVVILWCGAQLVMSVGQLITYNSLLTYFSNPIENIINLQTKLQSARVANNRLNEVYLVESEFNDTGTLSDSDFLAGDITFEDLSYKYGFGRDTLSDINLRIKKNDKVSIVGVSGSGKTTLAKIIVHFYDPYKGHIRINGNDLKTIDKTTLRQYINYLPQQAYIFSGTIFENLTLGAKEGISQADVLKACEIAEIRSDIEQMPMGYQTELSDGAGLSGGQKQRVALARALLTKSPVLILDEATSSLDVLTEKKIMDNLLQMADKTVAQYLSADR","1786402","For other components see SMu1726 (SBP1).","ABC transporter, ATP-binding and permease element","Membrane, Cytoplasm, Extracellular","Matches in gapped BLAST to conserved hypotheticals and to ComA-related ABC transport elements. Residues 5-495 are 74% similar to gi|15902512 from S.pneumoniae. Residues 14-495 are 64% similar to gi|1698421 from S.gordonii.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1337 (1e-44).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[1-262]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[445-487]T$	ABC_transporter
PF00005	$\"[334-489]T$	ABC_tran
PS00211	$\"[445-459]T$	ABC_TRANSPORTER_1
PS50893	$\"[308-503]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[333-503]T$	AAA

InterPro
IPR005897
Family

Peptidase C39, ABC-type bacteriocin transporter
TIGR01193	$\"[1-501]T$	bacteriocin_ABC

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[1-274]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[273-493]T$	G3DSA:3.40.50.300
PTHR19242	$\"[1-487]T$	PTHR19242
PTHR19242:SF91	$\"[1-487]T$	PTHR19242:SF91
SSF52540	$\"[308-492]T$	SSF52540
SSF90123	$\"[2-302]T$	SSF90123

noIPR
unintegrated

unintegrated
PTHR19242	$\"[9-40]T$	ATP-BINDING CASSETTE TRANSPORTER
PTHR19242:SF53	$\"[9-40]T$	ABC TRANSPORTER (SPAT)

","BeTs to 11 clades of COG1132COG name: ABC-type multidrug/protein/lipid transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1132 is ---KYQVCEBRHUJGP--inXNumber of proteins in this genome belonging to this COG is 16","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Mar 9 14:34:04 2002","Sat Mar 9 14:31:15 2002","Tue Oct 15 15:35:58 2002","Tue Oct 15 15:35:58 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1725 is paralogously related (blast p-value < 1e-3) to SMu0258, SMu1710, SMu0476, SMu0837, SMu0825, SMu0836, SMu0824, SMu1064, SMu0986, and SMu0475, all ABC transport-related proteins.","Sat Mar 9 14:34:04 2002","","No significant hits to the NCBI PDB database.","SMU.1899","","No significant hits to the Pfam 11.0 database","Sat Mar 9 14:31:15 2002","24380251","","","","","","1","","15","SMU.1899","" "SMu1726","1786502","1787515","1014","ATGAACCCAAATTTATTTAAAAGCGCTGAATTCTACCGAAGACGCTATCATAATTTTGCTACAGTTCTTATTATTCCTTTGGTTTGTTTACTTGTATTTTTATTTATCTTTCTATTATTTGCTAAAAAAGAGGTCACTGTCTTGTCTGATGGCGAGATCTCTCCCATTAAAGTAATTGATGTTATTCAATCTAAAAGTGATTATCCCATTTCTGAAAATAATTTAACAGATAATCACGCCGTTAAAAAAAGGGATGTTCTCATCCAATATGTTAATCCAGCAGCAAATACAAGACAGGGCGGAAATAATCAGAATCAAAATCAATCTCAAAACAAGCAAAATAAGAATCAGCAGCAAAACAATAAGAATCAAAAAAACGGCAATCAAGGTCAAAAAAATCAAAATCAGAACCAAAATAAAAAGGATCAGAAAAACAATAACCAATCTCAGCAAAACAAGCAAGGACAAAAGAAAACTAATCAATCCCAAAATCAGCAGAATAAGAATCAAAATAAAAACCAATCTCAAAACAAACAAAATGGGAATCAAAACCAAAATAACTGGAATCAGAATAATCAAAATGATAAAGTCACAGCCAGCCAAGATGGTGTTATCCATACCAACCCCAAATATGAAGGTGAAAACTTAATTCCTCGGGGGACTGAAATCGCACAGCTCTATCCAGATATTAACAAAACAAGACAAGTTCTGATCACTTATTACGTCTCCTCTAAAGATGTCACCCGCCTCAAACAAGGCCAAAAGACTCATCTTGCTTTAACCAAGGTAGGAAATGATCAAATTTCCATTAGAGGAAAAATTAATAGTATCGCTTCAGCTGCTACAACGACGAAAAAAGGCAATGTTTTTAAAGTGACAGCTAAAGCAAAAGTTTCTAAAAAAGACAGCCAAACCATTAAATACGGCCTCCAGGGTAAAACCATCACAGTTGTTGAAAAAAAGACTTTCTTTGATTATTATAAAGATAAACTGTTAAATAAAAATCAAAAATAA","10.90","31.90","38485","MNPNLFKSAEFYRRRYHNFATVLIIPLVCLLVFLFIFLLFAKKEVTVLSDGEISPIKVIDVIQSKSDYPISENNLTDNHAVKKRDVLIQYVNPAANTRQGGNNQNQNQSQNKQNKNQQQNNKNQKNGNQGQKNQNQNQNKKDQKNNNQSQQNKQGQKKTNQSQNQQNKNQNKNQSQNKQNGNQNQNNWNQNNQNDKVTASQDGVIHTNPKYEGENLIPRGTEIAQLYPDINKTRQVLITYYVSSKDVTRLKQGQKTHLALTKVGNDQISIRGKINSIASAATTTKKGNVFKVTAKAKVSKKDSQTIKYGLQGKTITVVEKKTFFDYYKDKLLNKNQK","1787525","For other components see SMu1724 (NBD1) and (MSD1).","ABC transporter","Extracellular","Matches in gapped BLAST to conserved hypothetical proteins and to BlpC ABC transporter proteins. Residues 197-332 are 50% similar to residues 314-449 of gi|15900443 in S.pneumoniae. Residues 1-90 are 50% similar to residues 1-90 of this protein. Residues 1-90 and residues 196-333 are 40% and 41% similar to gi|1698422, a predicted ComB protein, from S.gordonii.SMu1726 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006144
Domain

HlyD secretion protein, C-terminal
PS00543	$\"[306-328]?$	HLYD_FAMILY

","No hits to the COGs database.","***** IPB002215 (HlyD family secretion protein) with a combined E-value of 5.3e-07. IPB002215A 56-92 IPB002215B 197-231 IPB002215C 309-331","Residues 282-332 are 58% similar to a (TRANSPORT ACCESSORY TRANSMEMBRANE) protein domain (PD224420) which is seen in Q9EU69_STRPN.Residues 197-277 are 48% similar to a (TRANSPORT ACCESSORY TRANSMEMBRANE) protein domain (PD007371) which is seen in Q9EU69_STRPN.Residues 1-78 are 50% similar to a (TRANSPORT SECRETION ABC TRANSMEMBRANE) protein domain (PD225235) which is seen in Q9EU69_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:28:42 2002","Mon Oct 28 14:21:02 2002","Mon Oct 28 14:21:02 2002","Sat Mar 9 15:09:31 2002","Sat Mar 9 15:09:31 2002","Sat Mar 9 15:09:31 2002","yes","Mon Oct 28 14:21:09 2002","SMu1726 is paralogously related (blast p-value < 1e-3) to SMu0259, a comB related protein, to SMu0382, a predicted translation factor 2, and to SMu0764, a hypothetical.","Sat Mar 9 15:11:12 2002","","No significant hits to the NCBI PDB database.","SMU.1900","","No significant hits to the Pfam 11.0 database","Sat Mar 9 15:09:31 2002","24380252","","","","","","1","","15","SMU.1900","" "SMu1727","1787920","1787777","144","ATGAATTATTCAAAAAATCATGTAAAGTCATTGACAGAAACTGAGTTGATGGCTATTGTTGGCGGTGCTTTTTATCAAAGAAAAGAAAATGTTATTTCTCTTGATCCAAGAGAGTGGCTAGGTTTTAATGTAACAGAAAAATAA","7.50","0.22","5428","MNYSKNHVKSLTETELMAIVGGAFYQRKENVISLDPREWLGFNVTEK","1787793","","hypothetical protein","Cytoplasm","No significant hits in gapped BLAST.SMu1727 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:24:13 2002","Sat Mar 9 15:12:23 2002","Tue Oct 8 15:24:13 2002","Sat Mar 9 15:12:23 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1727 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:24:13 2002","","No significant hits to the NCBI PDB database.","SMU.1902c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 15:12:23 2002","24380253","","","","","","1","","15","SMU.1902c","" "SMu1728","1788139","1787987","153","ATGAAAACAACAAAGAAGCTAATAATAGTCATTATTCTTACACCCCTTGCCTTTTTTCTAGGCTGGTTATTGTGGCCTATTTCAAAATATATAGCTGTTATAGCCTTTATATTAGCTATGGGTGGGAATATTTTCGAATATTTTTTAGAATAA","10.20","1.98","5745","MKTTKKLIIVIILTPLAFFLGWLLWPISKYIAVIAFILAMGGNIFEYFLE","1788003","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu1728 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-35]?$	signal-peptide
tmhmm	$\"[5-25]?$ $\"[31-49]?$	transmembrane_regions

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[116-245]T$	IPR012336

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 130-238 are 23% similar to a (PLASMID PEDIOCIN BIOSYNTHESIS PA-1) protein domain (PD099684) which is seen in PEDC_PEDAC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Mar 9 15:46:17 2002","Sat Mar 9 15:44:26 2002","Sat Mar 9 15:46:17 2002","Sat Mar 9 15:44:26 2002","","Sat Mar 9 15:44:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1729 is paralogously related (blast p-value < 1e-3) to SMu1628, a bacteriocin related transport protein, and to SMu0057, SMu0999, and SMu1947, all conserved hypotheticals.","Sat Mar 9 15:46:17 2002","","No significant hits to the NCBI PDB database.","SMU.1904c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 15:44:26 2002","24380255","","","","","","1","","15","SMU.1904c","" "SMu1730","1789908","1789720","189","ATGGAAAAACAATATAATAATTTTAAAATATTAAATACTGATGCATTGGAAAATATTCAAGGCGGCGGTCGAGCTCCTAGGTGTGCTGCCCTTGTGGGAGCAAGTATTTATGATGGCTTAGCAGTAGTTGGAGATCCTGTTGGAGTTGCCATGGCAGCCGGTACAATTGCAGCGGGAAGTTTTTGTTGA","4.70","-1.12","6242","MEKQYNNFKILNTDALENIQGGGRAPRCAALVGASIYDGLAVVGDPVGVAMAAGTIAAGSFC","1789736","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST.SMu1730 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010133
Domain

Bacteriocin-type signal sequence
TIGR01847	$\"[8-22]T$	bacteriocin_sig: bacteriocin-type signal se

","BeTs to 4 clades of COG2217COG name: Cation transport ATPasesFunctional Class: PThe phylogenetic pattern of COG2217 is AmT-YQvCEBRhUJ---lin-Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:10:23 2002","Tue Oct 8 15:10:23 2002","Tue Oct 8 15:21:20 2002","Tue Oct 8 15:10:23 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1730 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:10:23 2002","","No significant hits to the NCBI PDB database.","SMU.1905c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 15:48:05 2002","24380256","","","","","","1","","15","SMU.1905c","" "SMu1731","1790284","1790072","213","ATGAATACACACGTATTGGAACAATTTGACGTCATGGATAGTCAAGTACCTTCAGCTATTGAAGGTGGGGGATGTAGTTGGAAAGGAGCCGATAAAGCTGGTTTTTCAGGTGGCGTTGGTGGTCTCATTGGTGCAGGTGGTAACCCCGTTGGTGGAGTCCTTGGAATAGCTGGTGGCTTAGATGCATACGGTGAACTTGTTGGAGGTAATTAA","4.00","-4.83","6660","MNTHVLEQFDVMDSQVPSAIEGGGCSWKGADKAGFSGGVGGLIGAGGNPVGGVLGIAGGLDAYGELVGGN","1790088","Kreth et al., 2005, state that this gene is regulated by the competence system.","bacteriocin-related protein","Extracellular","No significant hits in gapped BLAST.SMu1731 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jun 30 14:33:56 2005","Thu Jun 30 14:33:36 2005","Thu Jun 30 14:33:36 2005","Sat Mar 9 15:49:14 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1731 is paralogously related (blast p-value < 1e-3) to SMu1738, SMu0384, SMu1716, SMu0133, and SMu1722, hypothetical proteins, some with bacteriocin relatedness.","Sat Mar 9 15:51:07 2002","","No significant hits to the NCBI PDB database.","SMU.1906c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 15:49:14 2002","24380257","","Kreth J, Merritt J, Shi W, Qi F.Co-ordinated bacteriocin production and competence development: a possible mechanism for taking up DNA from neighbouring species.Mol Microbiol. 2005 Jul;57(2):392-404.PMID: 15978073","","Thu Jun 30 14:33:36 2005","","1","","15","SMU.1906c","" "SMu1732","1790364","1790495","132","ATGGAGCAAAATATCCTAAACGGTAGCTATTTTGTCCTAAACGGTAAAAATGCCAAATTTCTATTAGAAATTGACAAATTGACCCTTCCTGACAAATTAGCAACTTTGCCTGTACCGCATCAAGTTAGATAA","9.30","1.22","4862","MEQNILNGSYFVLNGKNAKFLLEIDKLTLPDKLATLPVPHQVR","1790505","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST.SMu1732 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:09:20 2002","Sat Mar 9 15:52:22 2002","Tue Oct 8 15:09:20 2002","Sat Mar 9 15:52:22 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1732 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:09:20 2002","","No significant hits to the NCBI PDB database.","SMU.1907","","No significant hits to the Pfam 11.0 database","Sat Mar 9 15:52:22 2002","24380258","","","","","","1","","15","SMU.1907","" "SMu1733","1790853","1790689","165","ATGAAAAAGTATTTAGTAGTACCTTTTGCCTTGATAATCATATTTTTAGGAGTTAAGGTTCTTTTGACTTCAAATAACATTTGGCAGATGATGTTTGCATCTATCGGTATGCTATTGTTTTTATTTGGCGTTTTTAGAGAATACAGCAAGATAAAAACAAAATAA","11.00","5.97","6286","MKKYLVVPFALIIIFLGVKVLLTSNNIWQMMFASIGMLLFLFGVFREYSKIKTK","1790705","","hypothetical protein","Membrane, Cytoplasm","No significant hits in gapped BLAST.SMu1733 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-23]?$	signal-peptide
tmhmm	$\"[2-21]?$ $\"[27-45]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-25]?$	signal-peptide
tmhmm	$\"[10-30]?$ $\"[40-60]?$ $\"[81-99]?$ $\"[109-127]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
tmhmm	$\"[21-39]?$ $\"[43-61]?$ $\"[88-106]?$ $\"[116-134]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
SSF103473	$\"[6-131]T$	SSF103473

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 18-131 are 26% similar to a (MEMBRANE BLPL) protein domain (PD296936) which is seen in Q9ETK8_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sat Mar 9 16:09:38 2002","Sat Mar 9 16:08:55 2002","Sat Mar 9 16:09:38 2002","Sat Mar 9 16:08:55 2002","","Sat Mar 9 16:08:55 2002","no","Tue Oct 8 15:06:04 2002","SMu1737 is paralogously related (blast p-value < 1e-3) to SMu0839, a hypothetical protein.","Sat Mar 9 16:09:38 2002","","No significant hits to the NCBI PDB database.","SMU.1913c","","No significant hits to the Pfam 11.0 database","Sat Mar 9 16:08:55 2002","24380263","","","","","","1","","15","SMU.1913c","" "SMu1738","1794741","1794511","231","ATGAATACACAAGCATTTGAACAATTTAACGTAATGGATAATGAAGCACTTTCAGCTGTTGAAGGTGGGGGCCGCGGATGGAATTGTGCAGCAGGTATTGCTCTAGGTGCTGGGCAAGGTTATATGGCTACTGCAGGCGGTACAGCATTTCTTGGTCCATATGCTATTGGCACTGGTGCCTTTGGGGCTATTGCTGGAGGAATCGGAGGAGCTCTTAATTCCTGTGGTTAG","3.90","-3.12","7245","MNTQAFEQFNVMDNEALSAVEGGGRGWNCAAGIALGAGQGYMATAGGTAFLGPYAIGTGAFGAIAGGIGGALNSCG","1794527","Kreth et al., 2005, state that this gene is regulated by the competence system.","bacteriocin immunity protein, BlpO-like","Extracellular","Matches in gapped BLAST to bacteriocin, BlpO-like sequences. Residues 1-44 are 52% similar to gi15900454 from S.pneumoniae. Residues 1-27 are 70% similar to gi11095283 from a Strep sp.SMu1738 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010133
Domain

Bacteriocin-type signal sequence
TIGR01847	$\"[9-23]T$	bacteriocin_sig: bacteriocin-type signal se

noIPR
unintegrated

unintegrated
tmhmm	$\"[50-72]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Jun 30 14:32:14 2005","Sat Mar 9 16:12:36 2002","Thu Jun 30 14:32:14 2005","Sun Jan 13 15:28:34 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1738 is paralogously related (blast p-value < 1e-3) to SMu0384, SMu1731, SMu1716, SMu0133, SMu1722, SMu0558, SMu0270, and SMu0254, all hypotheticals, some with bacteriocin relatedness.","Sat Mar 9 16:14:44 2002","","No significant hits to the NCBI PDB database.","SMU.1914c","","No significant hits to the Pfam 11.0 database","Sun Jan 13 15:28:34 2002","24380264",""," Matsumoto-Nakano M, Kuramitsu HK.Role of bacteriocin immunity proteins in the antimicrobial sensitivity of Streptococcus mutans.J Bacteriol. 2006 Dec;188(23):8095-102. Epub 2006 Sep 22.PMID: 16997961Kreth J, Merritt J, Shi W, Qi F.Co-ordinated bacteriocin production and competence development: a possible mechanism for taking up DNA from neighbouring species.Mol Microbiol. 2005 Jul;57(2):392-404.PMID: 15978073Bekal-Si Ali S, Hurtubise Y, Lavoie MC, LaPointe G.Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes.Gene. 2002 Jan 23;283(1-2):125-31.PMID: 11867219","","Thu Jun 30 14:32:14 2005","","1","","15","SMU.1914c","" "SMu1739","1795008","1795148","141","ATGAAAAAAACACTATCATTAAAAAATGACTTTAAAGAAATTAAGACTGATGAATTAGAGATTATCATTGGCGGAAGCGGAAGCCTATCAACATTTTTCCGGCTGTTTAACAGAAGTTTTACACAAGCTTTGGGAAAATAA","10.50","2.98","5193","MKKTLSLKNDFKEIKTDELEIIIGGSGSLSTFFRLFNRSFTQALGK","1795158","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0451 (comF);SMu0452 (comFC); SMu0490 (comC);SMu1782 (comA);SMu1684 (comEB); SMu1710 (comA) and SMu1740 (comD).","S. mutans specific competence stimulating peptide, precursor","Extracellular, Cytoplasm","This sequence corresponds to the previously published gi|12698430, gi|12698428|, and >gi|12698434 in GenBank. There are no other signnificant matches to SMu1739.SMu1739 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 25 07:06:15 2003","Sat Mar 9 16:25:10 2002","Tue Oct 15 15:29:25 2002","Sat Mar 9 16:20:51 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1739 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sat Mar 9 16:25:10 2002","","No significant hits to the NCBI PDB database.","SMU.1915","","No significant hits to the Pfam 11.0 database","Sat Mar 9 16:20:51 2002","24380265",""," Matsumoto-Nakano M, Kuramitsu HK.Role of bacteriocin immunity proteins in the antimicrobial sensitivity of Streptococcus mutans.J Bacteriol. 2006 Dec;188(23):8095-102. Epub 2006 Sep 22.PMID: 16997961 Petersen FC, Fimland G, Scheie AA.Purification and functional studies of a potent modified quorum-sensing peptide and a two-peptide bacteriocin in Streptococcus mutans.Mol Microbiol. 2006 Sep;61(5):1322-34.PMID: 16925560Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209","Cheng Q, Campbell EA, Naughton AM, Johnson S, Masure HR.The com locus controls genetic transformation in Streptococcus pneumoniae.Mol Microbiol. 1997 Feb;23(4):683-92.PMID: 9157240","Fri Oct 25 15:12:32 2002","Tue Mar 25 07:06:15 2003","1","","","SMU.1915","" "SMu1740","1796615","1795290","1326","ATGAATGAAGCCTTAATGATACTTTCAAATGGTTTATTAACTTATCTAACCGTTCTATTTCTCTTGTTTCTATTTTCTAAGGTAAGTAATGTCACTTTATCGAAAAAGGAATTAACTCTTTTTTCGATAAGCAATTTTCTGATAATGATTGCTGTTACGATGGTGAACGTAAACCTGTTTTATCCTGCAGAGCCTCTTTATTTTATAGCTTTATCAATTTATCTTAATAGACAGAATAGTCTTTCTCTAAATATATTTTATGGTCTGCTGCCTGTTGCCAGTTCTGACTTGTTTAGGCGGGCAATCATATTCTTTATCTTGGATGGAACTCAAGGAATTGTAATGGGCAGTAGCATTATAACCACCTATATGATCGAGTTTGCAGGAATAGCGCTAAGTTACCTCTTTCTCAGTGTGTTCAATGTTGATATTGGTCGACTTAAAGATAGTTTGACCAAGATGAAGGTCAAAAAACGCTTGATTCCAATGAATATTACTATGCTTCTATACTACCTTTTAATACAGGTATTGTATGTTATAGAGAGTTATAATGTGATACCGACTTTAAAATTTCGTAAATTTGTCGTTATTGTCTATCTTATTTTATTTTTGATTCTGATCTCATTTTTAAGCCAATATACCAAACAAAAGGTTCAAAATGAGATAATGGCACAAAAGGAAGCTCAGATTCGAAATATCACCCAGTATAGTCAGCAAATAGAATCTCTTTACAAGGATATTCGAAGTTTCCGCCATGATTATCTGAATATTTTAACTAGCCTCAGATTAGGCATTGAAAATAAAGATTTAGCTAGTATTGAAAAGATTTACCATCAAATCTTAGAAAAAACAGGACATCAATTGCAGGATACCCGTTATAATATCGGCCATCTAGCTAATATTCAAAACGATGCTGTCAAGGGTATCTTGTCAGCAAAAATCTTAGAAGCTCAGAATAAAAAGATTGCTGTCAATGTAGAAGTCTCAAGTAAAATACAACTGCCTGAGATGGAGTTGCTTGATTTCATTACCATACTTTCTATCTTGTGTGATAATGCCATTGAGGCTGCTTTCGAATCATTAAATCCTGAAATTCAGTTAGCCTTTTTTAAGAAAAATGGCAGTATAGTCTTTATCATTCAGAATTCCACCAAAGAAAAACAAATAGATGTGAGTAAAATTTTTAAAGAAAACTATTCCACTAAAGGCTCCAATCGCGGTATTGGTTTAGCAAAGGTGAATCATATTCTTGAACATTATCCCAAAACCAGTTTACAAACAAGCAATCATCATCATTTATTCAAGCAACTCCTAATAATAAAATAG","10.20","14.13","50529","MNEALMILSNGLLTYLTVLFLLFLFSKVSNVTLSKKELTLFSISNFLIMIAVTMVNVNLFYPAEPLYFIALSIYLNRQNSLSLNIFYGLLPVASSDLFRRAIIFFILDGTQGIVMGSSIITTYMIEFAGIALSYLFLSVFNVDIGRLKDSLTKMKVKKRLIPMNITMLLYYLLIQVLYVIESYNVIPTLKFRKFVVIVYLILFLILISFLSQYTKQKVQNEIMAQKEAQIRNITQYSQQIESLYKDIRSFRHDYLNILTSLRLGIENKDLASIEKIYHQILEKTGHQLQDTRYNIGHLANIQNDAVKGILSAKILEAQNKKIAVNVEVSSKIQLPEMELLDFITILSILCDNAIEAAFESLNPEIQLAFFKKNGSIVFIIQNSTKEKQIDVSKIFKENYSTKGSNRGIGLAKVNHILEHYPKTSLQTSNHHHLFKQLLIIK","1795306","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0451 (comF);SMu0452 (comFC); SMu0490 (comC);SMu1782 (comA);SMu1684 (comEB); SMu1710 (comA) and SMu1739 (comC).","histidine kinase","Membrane, Cytoplasm","Matches in gapped BLAST to histidine kinases. Residues 27-440 are 35% similar to gi|10303398 from S.pneumoniae. Residues 219-441 are 41% similar to residues 201-423 of gi|2564259| from L.plantarum.SMu1740 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
PF02518	$\"[337-420]T$	HATPase_c
SM00387	$\"[337-424]T$	HATPase_c
SSF55874	$\"[303-440]T$	ATP_bd_ATPase

noIPR
unintegrated

unintegrated
PTHR23283	$\"[233-418]T$	PTHR23283
PTHR23283:SF13	$\"[233-418]T$	PTHR23283:SF13

","BeTs to 6 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 217-434 are 47% similar to a (KINASE HISTIDINE COMD AGRC) protein domain (PD002560) which is seen in Q9F2F5_STRPN.Residues 233-420 are 28% similar to a (NATA NATB COMPLETE PROTEOME) protein domain (PD040486) which is seen in Q9EYJ7_LACRH.Residues 48-167 are 33% similar to a (KINASE HISTIDINE BLPH) protein domain (PD339116) which is seen in Q9S1I5_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Mar 25 07:05:39 2003","Tue Jan 8 12:04:33 2002","Tue Oct 15 15:28:27 2002","Thu Apr 4 10:16:32 2002","","Tue Jan 8 12:04:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1740 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sat Mar 9 16:30:15 2002","","No significant hits to the NCBI PDB database.","SMU.1916c","","No significant hits to the Pfam 11.0 database","Tue Jan 8 12:04:33 2002","",""," Ahn SJ, Wen ZT, Burne RA.Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159.Infect Immun. 2006 Mar;74(3):1631-42.PMID: 16495534Li YH, Tang N, Aspiras MB, Lau PC, Lee JH, Ellen RP, Cvitkovitch DG.A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation.J Bacteriol. 2002 May;184(10):2699-708.PMID: 11976299","Reichmann,P. and Hakenbeck,R.Allelic variation in a peptide-inducible two-component system ofStreptococcus pneumoniaeFEMS Microbiol. Lett. 190 (2), 231-236 (2000)PubMed: 11034284","Fri Oct 25 15:13:56 2002","Tue Mar 25 07:05:39 2003","1","","","SMU.1916c","" "SMu1741","1797364","1796612","753","ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGAAAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAATCACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCATAATCCTAGTGCAGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTTGGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACAGCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATTCTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTCTACGGCAGTATGACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTATTGATCGGAAAAAACGCTTGGCCTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGAGCTGTGATTGCTGATCAAAGGAGAGCAAAATGA","8.40","3.55","29344","MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGNHQIFFLDIEIKKEEKKGLEVANQIRQHNPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEILYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLRAVIADQRRAK","1796628","","response regulator","Cytoplasm","SMu1741 is similar to gi4538831 the comE gene of Streptococcus pneumoniae (1e-40).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1957 (6e-65).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[4-112]T$	Response_reg
PF00072	$\"[2-124]T$	Response_reg
SM00448	$\"[2-123]T$	REC
PS50110	$\"[3-127]T$	RESPONSE_REGULATORY

InterPro
IPR007492
Domain

LytTr DNA-binding region
PF04397	$\"[150-244]T$	LytTR
PS50930	$\"[144-245]T$	HTH_LYTTR

InterPro
IPR008246
Family

Response regulator, LytTR DNA-binding AlgR/VirR/ComE type
PIRSF006198	$\"[2-247]T$	RR_LytTR_AlgR

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-127]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[2-127]T$	G3DSA:3.40.50.2300

","BeTs to 3 clades of COG0745COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG0745 is -----QVCEBRHUJ----inXNumber of proteins in this genome belonging to this COG is 10","No significant hits to the Blocks database.","Residues 4-112 are 42% similar to a (RESPONSE REGULATOR PHOSPHORYLATION) protein domain (PD006702) which is seen in O32833_LACPL.Residues 145-236 are 47% similar to a (REGULATOR RESPONSE PHOSPHORYLATION) protein domain (PD006687) which is seen in O32833_LACPL.Residues 4-127 are 59% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in Q9F2F6_STRPN.Residues 155-239 are 38% similar to a (REGULATOR RESPONSE SENSORY TRANSDUCTION) protein domain (PD395697) which is seen in Q9S3T6_STALU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 11:29:26 2002","Tue Jan 8 12:05:33 2002","Thu Sep 21 08:34:11 2006","Tue Oct 15 15:27:44 2002","","Tue Jan 8 12:05:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1741 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 15 15:27:44 2002","","No significant hits to the NCBI PDB database.","SMU.1917c","","Residues 2 to 131 (E-value = 5.1e-05) place SMu1741 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 143 to 244 (E-value = 2.8e-28) place SMu1741 in the LytTR family which is described as LytTr DNA-binding domain (PF04397)","Thu Sep 21 08:34:11 2006","",""," Ahn SJ, Wen ZT, Burne RA.Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159.Infect Immun. 2006 Mar;74(3):1631-42.PMID: 16495534","","Tue Mar 25 07:22:30 2003","","1","","","SMU.1917c","981" "SMu1742","1798474","1797836","639","ATGTTTTTTATTGATTTTATTTTACATATTGATAACTATATTTATAGTATTGCCAATACCGTTGGCTTGTGGACTTACCTAATTCTATTTTTAGTAATCTTTGTGGAAACGGGTGTCGTCATTCTTCCTTTTCTGCCGGGAGACAGCCTCTTATTTGCAGCAGGTGCCTTAGCAGCCAATCCTAAGATGCACTTTAGTGTTTTAGTTTTTGGTATTTTATTTTTCATAGCTGCTTTTGTTGGAGATACTTGTAATTTCTTTATCGGTCGTACGGCTGGTTATCGTTTGGTGCATCACAAATTTTTCAGTCAATTTATTAAAGAAGATAATATCAAAGATGCTGAGCTTTATTTTGAAAAATACGGTTCAACTTCTATCATTTTAGGACGTTATATCCCAATTATCAGAACTTTTGTTCCTTTTGTAGCTGGCCTTAGTCAATTCCCTGTGTCTTCTTTTATTAAACGCAGTTTTATAGCTGCTTTATCTTGGACAGTGATTGCAGCAGGAGCTGGCTATCTTTTTGGTAACATTCCTTTTGTTAAAACACATTTTTCTGCTATTATCTTGGCTATTGTTTTTGTGACTTTACTACCAAGTGCTATTACTGTCGTCAAAACCAGCAAAAAGAAAAAATAA","10.40","8.14","23634","MFFIDFILHIDNYIYSIANTVGLWTYLILFLVIFVETGVVILPFLPGDSLLFAAGALAANPKMHFSVLVFGILFFIAAFVGDTCNFFIGRTAGYRLVHHKFFSQFIKEDNIKDAELYFEKYGSTSIILGRYIPIIRTFVPFVAGLSQFPVSSFIKRSFIAALSWTVIAAGAGYLFGNIPFVKTHFSAIILAIVFVTLLPSAITVVKTSKKKK","1797852","","membrane-associated protein DedA","Membrane, Cytoplasm","Matches in gapped BLAST to DedA-related proteins. Residues 2-212 are 41% similar to gi|16802090 from L.monocytogenes and 40% similar to >gi|16799114 from L.innocua.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0687 (6e-90).","

InterPro
IPR015414
Domain

SNARE associated Golgi protein
PF09335	$\"[45-174]T$	SNARE_assoc

","BeTs to 6 clades of COG0586COG name: Uncharacterized membrane-associated protein, DedA familyFunctional Class: SThe phylogenetic pattern of COG0586 is -------CEBRhUJ--ol---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 67-206 are 48% similar to a (COMPLETE PROTEOME TRANSMEMBRANE DEDA INTEGRAL ALKALINE) protein domain (PD002864) which is seen in Q9CES6_LACLA.Residues 22-58 are 72% similar to a (TRANSMEMBRANE PROTEOME COMPLETE DEDA) protein domain (PD305353) which is seen in DEDA_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 12:53:33 2002","Mon Mar 11 12:47:40 2002","Tue Oct 15 15:26:47 2002","Tue Oct 15 15:26:47 2002","","Mon Mar 11 12:47:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1742 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 12:53:33 2002","","No significant hits to the NCBI PDB database.","SMU.1918c","","Residues 27 to 191 (E-value = 1.1e-26) place SMu1742 in the DedA family which is described as DedA family (PF00597)","Mon Mar 11 12:47:40 2002","","","","","","","1","","","SMU.1918c","" "SMu1743","1799147","1798521","627","ATGTTTGAAAATCTAAAAGCTTATTTGACACAGCAAGGTTTTAAGTATATTAAACCAGAAAAGGCTGGTTCCTTGGCTGAAGAAATGATAGCTTTGAAAACCTTAGGACAATCTGCGCGTGCTGAATTTACAGAGATAGCTAAGGTGCTTGCTCTTAAAGTTTCTCCTTTTGAGATGATGCGTGTCAGTAATTGGGCTAATCAGGCACAAATTGCCAGACCGCATTTTTGGTGCTATTATAAACAACCTGAAGATAATCAGGACGATGTTGGACTTGCCATCAGGCTTTATGGGAATTCAGCTAATTTTGGTATTTCAGTAGAGGTCAGTTTTATTGAACGCAAAAAATCAAAGGCGACTCTAGCTAAACAGCATAAAGTTTTAGACATACCGATTGCTGAACCGCTTTATTATTTTGCTCAAGAGAAAAGTGAAAGTCATCGGGTTTCAGGAACAGAAGCTTATCGTCAGATGTTACGGCAAAAAGTTGCTGACGGTCAAGTTCGAAAAGTTTTGGTCAAGTATGACATACCTATATCAGAGGGATCAGATCTAGTTATACTAACTGATCAATTGGCTCAAGGCTTTGATAAATTGATGCCATATTATCAAGCAACTAAATTATAG","9.70","4.68","23693","MFENLKAYLTQQGFKYIKPEKAGSLAEEMIALKTLGQSARAEFTEIAKVLALKVSPFEMMRVSNWANQAQIARPHFWCYYKQPEDNQDDVGLAIRLYGNSANFGISVEVSFIERKKSKATLAKQHKVLDIPIAEPLYYFAQEKSESHRVSGTEAYRQMLRQKVADGQVRKVLVKYDIPISEGSDLVILTDQLAQGFDKLMPYYQATKL","1798537","---------------------------------------------The following comment was provided by Dragona Ajdic, University of Oklahoma Health Sciences Center.Analyses of this gene did not reveal resemblance to the other response regulators of S. mutans.","sakacin A production response regulator","Cytoplasm, Periplasm","This sequence corresponds to the previously sequenced gi6681651 in GenBank Residues 29-170 correspond to residues 1-142 of gi6681651. No other significant matches in GenBank.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0355 (2e-60).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 29-170 are 98% similar to a (A REGULATOR PRODUCTION SAKACIN) protein domain (PD300779) which is seen in Q9RHV4_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed May 1 15:07:07 2002","Mon Mar 11 12:58:34 2002","Thu Apr 5 12:57:37 2007","Mon Mar 11 12:58:34 2002","","Mon Mar 11 12:58:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1743 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 11 13:59:43 2002","","No significant hits to the NCBI PDB database.","SMU.1919c","","No significant hits to the Pfam 11.0 database","Wed May 1 14:45:29 2002","","","Kawabata,S., Terao,Y. and Hamada,S.Molecular cloning, sequence and characterization of a novelstreptococcal phosphoglycerate dehydrogenase geneOral Microbiol. Immunol. 15 (1), 58-62 (2000)PubMed: 11155166","Diep DB, Axelsson L, Grefsli C, Nes IF.The synthesis of the bacteriocin sakacin A is a temperature-sensitive process regulated by a pheromone peptide through a three-component regulatory system.Microbiology. 2000 Sep;146 ( Pt 9):2155-60.PMID: 10974103Axelsson L, Holck A, Birkeland SE, Aukrust T, Blom H.Cloning and nucleotide sequence of a gene from Lactobacillus sake Lb706 necessary for sakacin A production and immunity.Appl Environ Microbiol. 1993 Sep;59(9):2868-75.PMID: 8215360","Thu Apr 5 12:57:37 2007","Thu Apr 5 12:57:37 2007","1","","","SMU.1919c","" "SMu1744","1800532","1799222","1311","ATGGCTTTACCAACAGTTGCTATTGTCGGACGCCCAAATGTCGGCAAATCAGCGCTTTTTAATCGTATAGCTGGTGAGCGTATTTCCATCGTTGAGGATGTTGAAGGAGTAACAAGAGACCGCATTTATACAAAGGCGGAATGGCTTAATCGCCAATTTTCAATCATTGATACAGGCGGTATTGACGATGTTGATGCCCCCTTTATGGAACAAATTAAACATCAAGCTGATATTGCTATGACAGAGGCTGATGTGATTGTTTTTGTGGTATCTGCTAAGGAAGGTATCACAGATGCCGATGAATATGTAGCAAAGATTCTTTATCGGACACACAAGCCGGTTATTTTAGCTGTTAATAAAGTTGATAATCCTGAGATGCGCAGTGCTATTTATGATTTCTATGCCTTGGGACTGGGGGATCCTTATCCTGTTTCTTCTGCTCATGGTATTGGTACAGGAGATGTCCTTGATGCTATCGTTGATAATTTACCGACAGAAGCGCAAGAAGAGAGTTCAGACATTATTAAGTTTAGTTTGATCGGACGTCCCAATGTTGGTAAATCCAGTTTAATCAATGCTATCTTAGGAGAAGATCGTGTTATAGCATCACCAGTAGCTGGTACGACCCGTGATGCGATTGATACAACCTTCACGGATGAAGAAGGTCAAGAATTTACCATGATTGACACAGCTGGGATGCGTAAGTCAGGTAAAGTTTATGAAAATACAGAGAAATATTCTGTTATGCGTGCTATGCGTGCGATTGATCGCTCAGATATTGTTTTGATGGTGTTGAATGCTGAGGAAGGTATTCGTGAATACGACAAGCGCATTGCTGGTTTTGCTCATGAGGCTGGTAAAGGGATTGTTGTCGTTGTGAATAAGTGGGATGCGATTAAGAAAGATAATCGTACTGTTGCACAATGGGAAGCAGATATTCGTGACAATTTTCAATATATCCCTTATGCTCCCATTGTTTTTGTGTCAGCAGTTACCAAACAACGACTGCATAAACTGCCAGACGTGATTAAACAAGTAAGCCAAAGTCAAAATACCCGTATTCCATCAGCTGTTTTAAATGATGTTGTCATGGATGCTGTGGCAATCAATCCCACACCAACAGATAAAGGAAAGCGCCTCAAAATTTTTTATGCGACACAGGTTTCGGTCAAACCGCCAACCTTTGTTATTTTTGTTAATGAAGAAGAGCTGATGCATTTTTCTTATTTGCGTTTTTTGGAAAATCAAATTCGCCAAGCTTTTGTTTTTGAGGGAACCCCTATCCGCTTGATTGCAAGGAAACGGAAATAA","5.50","-6.51","48574","MALPTVAIVGRPNVGKSALFNRIAGERISIVEDVEGVTRDRIYTKAEWLNRQFSIIDTGGIDDVDAPFMEQIKHQADIAMTEADVIVFVVSAKEGITDADEYVAKILYRTHKPVILAVNKVDNPEMRSAIYDFYALGLGDPYPVSSAHGIGTGDVLDAIVDNLPTEAQEESSDIIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTTFTDEEGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDIVLMVLNAEEGIREYDKRIAGFAHEAGKGIVVVVNKWDAIKKDNRTVAQWEADIRDNFQYIPYAPIVFVSAVTKQRLHKLPDVIKQVSQSQNTRIPSAVLNDVVMDAVAINPTPTDKGKRLKIFYATQVSVKPPTFVIFVNEEELMHFSYLRFLENQIRQAFVFEGTPIRLIARKRK","1799238","","phosphoglycerate dehydrogenase","Cytoplasm","This sequence corresponds to the previously sequenced gi|6681650 in GenBank. In addition, residues 1-436 are 86% similar to gi|15901543 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1620 (0.0).","

InterPro
IPR002917
Domain

GTP-binding protein, HSR1-related
PF01926	$\"[4-122]T$ $\"[175-297]T$	MMR_HSR1

InterPro
IPR005225
Domain

Small GTP-binding protein domain
TIGR00231	$\"[1-161]T$ $\"[172-345]T$	small_GTP

InterPro
IPR005289
Domain

GTP-binding
TIGR00650	$\"[9-60]T$ $\"[180-214]T$	MG442

InterPro
IPR006073
Domain

GTP1/OBG
PR00326	$\"[177-197]T$ $\"[248-266]T$	GTP1OBG

InterPro
IPR009019
Domain

KH, prokaryotic type
G3DSA:3.30.300.20	$\"[344-436]T$	KH_prok

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[4-174]T$ $\"[175-341]T$	G3DSA:3.40.50.300
PTHR11649	$\"[1-436]T$	PTHR11649
PTHR11649:SF5	$\"[1-436]T$	PTHR11649:SF5
SSF52540	$\"[2-66]T$ $\"[68-345]T$	SSF52540
SSF82653	$\"[353-436]T$	SSF82653

","BeTs to 12 clades of COG1160COG name: Predicted GTPasesFunctional Class: RThe phylogenetic pattern of COG1160 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000765 (GTP1/OBG family) with a combined E-value of 1.3e-15. IPB000765 175-218 IPB000765 4-47","Residues 4-102 are 29% similar to a (HYDROCARBONS CAT ORF1 CATABOLISM) protein domain (PD139582) which is seen in YCT1_ACICA.Residues 68-179 are 35% similar to a (GTP-BINDING REPEAT ENGA) protein domain (PD173289) which is seen in ENGA_CHLPN.Residues 178-240 are identical to a (GTP-BINDING PROTEOME COMPLETE GTPASE HOMOLOG REPEAT) protein domain (PD000414) which is seen in Q9RHV5_STRMU.Residues 249-363 are identical to a (GTP-BINDING FACTOR INITIATION COMPLETE PROTEOME) protein domain (PD200055) which is seen in Q9RHV5_STRMU.Residues 364-431 are identical to a (GTP-BINDING REPEAT PROTEOME COMPLETE) protein domain (PD005185) which is seen in Q9RHV5_STRMU.Residues 72-164 are 46% similar to a (GTP-BINDING REPEAT PROTEIN-LIKE) protein domain (PD084499) which is seen in ENGA_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 13:02:46 2002","Mon Mar 11 12:59:29 2002","Tue Oct 15 15:16:51 2002","Tue Oct 15 15:16:51 2002","Mon Mar 11 12:59:29 2002","Mon Mar 11 12:59:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1744 is paralogously related (blast p-value < 1e-3) to SMu1130, a predicted thiophene and furan oxidation protein, to SMu1471 and SMu0903, GTP-binding proteins, to SMu0519, a predicted ferrous ion transport protein B, to SMu0496, a GTP-binding protein and to SMu0382, a translation initiation factor 2.","Mon Mar 11 13:12:30 2002","Mon Mar 11 12:59:29 2002","pdb|1EGA|B Chain B, Crystal Structure Of A Widely Conserved Gtp... 75 2e-014","SMU.1920c","","Residues 1 to 167 (E-value = 3.1e-05) place SMu1744 in the GTP_EFTU family which is described as Elongation factor Tu GTP binding domain (PF00009)Residues 72 to 323 (E-value = 8.3e-42) place SMu1744 in the MMR_HSR1 family which is described as GTPase of unknown function (PF01926)","Mon Mar 11 12:59:29 2002","","","Kawabata,S., Terao,Y. and Hamada,S.Molecular cloning, sequence and characterization of a novelstreptococcal phosphoglycerate dehydrogenase geneOral Microbiol. Immunol. 15 (1), 58-62 (2000)PubMed: 21069259","","Mon Mar 11 13:02:46 2002","","1","","","SMU.1920c","166" "SMu1745","1801444","1800545","900","GTGGAAACAATTGGACAGACATTGGCTAAAAAAGATAACCATAAGTATGATACAGAAAAAATGACTCAAGCCATTTTATCAGATCAGGAAATTGCTAATTTCATTGCTGCTCACCATCTGTCGAAAGAACAAATTAAAATTAGTTTACCTAAATTCAATCAATATCGTTTAGAGCGTACTCGCTTTGAAAATCATGATCAGGCCTATATTGCCAAGGGCTATCAGCCGCTTCTTGTAATGAATGAAGGTTATGCAGATGTCGCCTATAAAGAGACAAAAGAACTGATTGCTGCAAAGAAGACTCAAGCGATTTCTGACCGAATTAATGTGGTTAGTTTACCAAGATCTTATAAGAACATCTCCTTTGATGATATTAATCTTGATGATGTCAAGCGACTAGATGTTTTTAAAAGGGTAGCTGATTTTGTGGAGCAGTATCCGAATCCTGAGCAAAAAGGACTTTATCTTTATGGTGATATGGGAATTGGTAAGTCTTACCTCATGGCAGCCATGGCTCATGAATTGTCAGAACAAAGAGGAGCTGCAACGACACTGCTGCATTTTCCGAGTTTTACGATTGATGTCAAGAATGCCATCAACACAGGAACGGTTAAGAAAGAAATTGATGCTGTCAAGACGGCTGATATTTTGATTCTTGACGATATTGGTGCTGAACAAAGCACTTCTTGGATTCGTGATGAAGTTTTGCAGGTTATTTTACAATATCGGATGTTAGAAGAATTGCCAACCTTTTTTACCTCTAATTATAGTTTTAAGGATTTAGAGGCGAAATTAGCGAATATAAAAGGGAGCGATGAAACTTGGCAGGCTAAGCGTGTGATGGAGCGTATTCGTTATTTAGCAAAAGAAATTCACCTTGAAGGTGAAAATAGAAGATAA","6.40","-2.29","34365","METIGQTLAKKDNHKYDTEKMTQAILSDQEIANFIAAHHLSKEQIKISLPKFNQYRLERTRFENHDQAYIAKGYQPLLVMNEGYADVAYKETKELIAAKKTQAISDRINVVSLPRSYKNISFDDINLDDVKRLDVFKRVADFVEQYPNPEQKGLYLYGDMGIGKSYLMAAMAHELSEQRGAATTLLHFPSFTIDVKNAINTGTVKKEIDAVKTADILILDDIGAEQSTSWIRDEVLQVILQYRMLEELPTFFTSNYSFKDLEAKLANIKGSDETWQAKRVMERIRYLAKEIHLEGENRR","1800561","For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0074 (dnaK);SMu075 (dnaJ); SMu0745 (dnaG); SMu1091 (dnaE); SMu1746 (dnaB);SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC). ","DNA replication protein; primosome component","Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1621 (1e-114).","

InterPro
IPR005654
Family

AFG1-like ATPase
PTHR12169	$\"[119-200]T$	ATPASE N2B

InterPro
IPR009928
Domain

Primosomal DnaI, N-terminal
PF07319	$\"[2-108]T$	DnaI_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[113-262]T$	no description

","BeTs to 4 clades of COG1484COG name: DNA replication protein DnaCFunctional Class: LThe phylogenetic pattern of COG1484 is -----q--EBR----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 1-115 are 35% similar to a (PROTEOME PRIMOSOMAL COMPLETE ORF12) protein domain (PD110515) which is seen in Q9CHH9_LACLA.Residues 224-299 are 63% similar to a (PRIMOSOMAL DNAI ATP-BINDING COMPLETE) protein domain (PD413695) which is seen in Q9CHH9_LACLA.Residues 118-223 are 43% similar to a (PROTEOME PRIMOSOMAL COMPLETE DNAI) protein domain (PD393760) which is seen in Q9CHH9_LACLA.Residues 152-263 are 31% similar to a (HELICASE PROTEOME COMPLETE) protein domain (PD339610) which is seen in Q9RFQ3_MYCFE.Residues 122-255 are 45% similar to a (REPLICATION ATP-BINDING DNA-BINDING INITIATOR) protein domain (PD066439) which is seen in Q9K863_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Sep 18 15:01:48 2006","Mon Mar 11 13:13:35 2002","Mon Sep 18 15:01:48 2006","Thu Mar 28 10:25:31 2002","","Mon Mar 11 13:13:35 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1745 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome. It is weakly similar to M102_023 in the M102 phage.","Thu Jun 29 11:21:14 2006","","No significant hits to the NCBI PDB database.","SMU.1921c","","Residues 2 to 108 (E-value = 4e-53) place SMu1745 in the DnaI_N family which is described as Primosomal protein DnaI N-terminus (PF07319)","Mon Mar 11 13:13:35 2002","","","","","","","1","","","SMU.1921c","447" "SMu1746","1802614","1801445","1170","ATGAAACCAATTGATGAATTTCTCTATGTCAAGCAAAATTATTTGACTTCTGATACAAATAGTTTGATGCGCCTTTATTTTCCGATTATTGGCAGTGATGCTGCTGGGCTTTATCAATATTTTGTCAGTTTTTTTGATAACGGTGAAAAGAAGCACAAATTTAGTGAGATTCTCAATCATACTCAATTTGGAATGGCTTGTTTTGAGAATGCCTTATCTGTACTGACGGCTATGGATTTGTTAGTTTTTTATCGACAAGAAAATCTTTATTATATTAAACTAAAAGCTCCTTTAAATGCAGAAACTTTTCTAAAAAATGCTGTCTATCGCCATCTTTTAGAACAAAAAATTGGACAAGTTGCAGTTGAACATTTGGATTTACATCTTCCCCGAGAAGCCCAAGACCTTTCTAAACAATTTTCTGAAGTTTTTACTGCTGCAGGTCAACTCGATTTAAAAACACCCAAGAGTAAGACGGATTTTGACTTAGATCATTTTAAGGATTTAATGATACGAGATAACTTGCAATTTACTGATGAACAAACAGATGTTATTGCGTTGTACATCCTTTCTGAGAAATATCAGCTTACTTGGTATGAGACCTATCTTTTAGCTAAAGAGACTGCTAGCAATTATAGAATTTCTCTGAAACGTATGCAAGCTAAACAAGAACAAAGGGATCATGTTGATGCAGATAACTCTTTTTCTAAAAAGGAACAAATTATTATAGAAGAGGCTAAAGCTGACAAAGTAGAAGTTTTCCTTGCTAAAATAAAAAAAACAAGGCATGCTGCTATTACAAAGGATGAACGCAGCTTGTTAGCAGAGCTTGCAGAGATGGGCTTTTTGGATGAGGTTATCAATATTATGCTGCTGTATACTCTTGATAAAACAAATACAGCTAATATTAACAAGACTTATATCATGAAAATTGCGAATGATTTTGCTTTTCAAAAGATAGACAGTGCAGAAAAGGCAGTACTTAAACTACGTAGCTTTGCCGAACGTAAAACAAAGCAAAATCAAAAAAAAATAAAAGAAAGCTCAAAAAACAATGTTCCTGAATGGAGCAATCAAGACTATCAAAATAATACAACTGCAGATGAGCAGGCTCGTTTAGACGAGATTAAACGCAAAACTTTAGCAAGATTGAGAAGGGATGGTGAGTAA","7.30","0.92","45352","MKPIDEFLYVKQNYLTSDTNSLMRLYFPIIGSDAAGLYQYFVSFFDNGEKKHKFSEILNHTQFGMACFENALSVLTAMDLLVFYRQENLYYIKLKAPLNAETFLKNAVYRHLLEQKIGQVAVEHLDLHLPREAQDLSKQFSEVFTAAGQLDLKTPKSKTDFDLDHFKDLMIRDNLQFTDEQTDVIALYILSEKYQLTWYETYLLAKETASNYRISLKRMQAKQEQRDHVDADNSFSKKEQIIIEEAKADKVEVFLAKIKKTRHAAITKDERSLLAELAEMGFLDEVINIMLLYTLDKTNTANINKTYIMKIANDFAFQKIDSAEKAVLKLRSFAERKTKQNQKKIKESSKNNVPEWSNQDYQNNTTADEQARLDEIKRKTLARLRRDGE","1801461","For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0074 (dnaK);SMu075 (dnaJ); SMu0745 (dnaG); SMu1091 (dnaE); SMu1745 (dnaI);SMu1437 (dnaX),(dnaH) and SMu1940 (dnaC).","chromosome replication initiation and membrane attachment protein","Cytoplasm","Matches in gapped BLAST to hypothetical proteins and to chromosome replication proteins. Residues 1-389 are 50% similar to gi15674496 from S.pyogenes. Residues 1-386 are 46% similar to gi15903599 from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1622 (1e-115).","

InterPro
IPR010833
Family

Replication initiation and membrane attachment
PF07261	$\"[1-383]T$	DnaB_2

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 192-366 are 27% similar to a (REPLICATION PROTEOME ATTACHMENT COMPLETE) protein domain (PD407831) which is seen in Q9CHI0_LACLA.Residues 1-191 are 31% similar to a (PROTEOME COMPLETE DNAB REPLICATION) protein domain (PD399838) which is seen in Q9CHI0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 16:01:47 2006","Thu Aug 31 16:01:47 2006","Thu Aug 31 16:01:47 2006","Mon Mar 11 13:18:15 2002","","Mon Mar 11 13:18:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1746 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Mar 11 13:23:23 2002","","No significant hits to the NCBI PDB database.","SMU.1922c","","Residues 1 to 383 (E-value = 4.4e-07) place SMu1746 in the DnaB_2 family which is described as Replication initiation and membrane attachment protein (DnaB) (PF07261)","Mon Mar 11 13:18:15 2002","","","","Hoshino,T., McKenzie,T., Schmidt,S., Tanaka,T. and Sueoka,N.Nucleotide sequence of Bacillus subtilis dnaB: a gene essential for DNA replication initiation and membrane attachmentProc. Natl. Acad. Sci. U.S.A. 84 (3), 653-657 (1987)PubMed: 3027697 Ogasawara,N., Moriya,S., Mazza,P.G. and Yoshikawa,H.Nucleotide sequence and organization of dnaB gene and neighbouringgenes on the Bacillus subtilis chromosomeNucleic Acids Res. 14 (24), 9989-9999 (1986)PubMed: 3027671","","Thu Mar 28 10:26:19 2002","1","","","SMU.1922c","597" "SMu1747","1803092","1802601","492","ATGCGTTGTCCAAAATGTAATTATCTAAAATCCAGTGTTGTTGATAGCCGTCAAGCTGAGGAAGGAAACACCATTAGACGCCGTCGGGAATGTGAAAATTGTCATACACGCTTTACAACTTTTGAAAGAATTGAGGAATTACCGCTTTTAGTTGTTAAAAAAGATGGTACCAGAGAGCAATTTTCTCGTGACAAAATTTTCAATGGTATTATTAGAAGTGCTCAAAAACGTCCAGTATCTAGCAGTGCTATTGAAAAAGTTGTCAATGATATTGAACAAAAAATTCGCAGTGATTATGATAGTGAAGTATCTAGCGTTGTTATTGGGAATTTAGTTATGGATGAGTTGGCAGAACTTGATGAAATTACCTATGTTCGTTTTGCCAGTGTTTACCGTAGTTTCAAAGATGTTGATGAGATTGAAGCTCTTTTGCAGCAAATCACAAATCGTGTAAGAAGTAAGAAAAAGAGAAAAGCAGATGAAACCAATTGA","8.50","3.06","18965","MRCPKCNYLKSSVVDSRQAEEGNTIRRRRECENCHTRFTTFERIEELPLLVVKKDGTREQFSRDKIFNGIIRSAQKRPVSSSAIEKVVNDIEQKIRSDYDSEVSSVVIGNLVMDELAELDEITYVRFASVYRSFKDVDEIEALLQQITNRVRSKKKRKADETN","1802617","","conserved hypothetical protein","Cytoplasm","Matches in gapped BLAST to conserved hypothetical proteins. Residues 1-163 are 82% similar to gi|15674495 from S.pyogenes. Residues 1-157 are 75% similar to gi|15903600| from S.pneumoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1623 (4e-70).","

InterPro
IPR003796
Family

Ribonucleotide reductase regulator NrdR-like
TIGR00244	$\"[1-147]T$	RNR_NrdR-like

InterPro
IPR005144
Domain

ATP-cone
PF03477	$\"[49-139]T$	ATP-cone
PS51161	$\"[49-139]T$	ATP_CONE

","BeTs to 6 clades of COG1327COG name: Uncharacterized BCRFunctional Class: SThe phylogenetic pattern of COG1327 is ------vcebrh------in-Number of proteins in this genome belonging to this COG is 1","***** IPB003796 (DUF193) with a combined E-value of 1e-57. IPB003796A 26-80 IPB003796B 101-149","Residues 25-150 are 65% similar to a (COMPLETE PROTEOME ORF DNAB) protein domain (PD006144) which is seen in Q9CHI1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Mar 11 13:28:37 2002","Mon Mar 11 13:27:46 2002","Mon Mar 11 13:28:37 2002","Tue Oct 8 15:02:06 2002","Mon Mar 11 13:27:46 2002","Mon Mar 11 13:27:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1747 is paralogously related (blast p-value < 1e-3) to SMu1882, a predicted anaerobic ribonucleoside-triphosphate reductase.","Mon Mar 11 13:28:37 2002","","No significant hits to the NCBI PDB database.","SMU.1923c","","Residues 49 to 139 (E-value = 1.1e-30) place SMu1747 in the ATP-cone family which is described as ATP cone domain (PF03477)","Mon Mar 11 13:27:46 2002","24380273","","","","","","1","","","SMU.1923c","714" "SMu1748","1804154","1803462","693","ATGGCTAAGGACATTTTAATTATTGAAGATGAAAAAAAACTTGCAAAGTTTGTTTCTTTAGAATTACAACATGAAGGATATGAGGTTGAAGTGACATATGATGGGCGTTCTGGCCTGGAAAGAGCACTTGAAAAAGATTTCGATCTCATCCTTCTTGATTTAATGTTACCAGAGATGGACGGGTATGAAGTGATTCGTCGTTTACAATTGGAAAAGACAACTTATGTTATTATTATCACTGCTCGTGACTCTATTATGGATATTGTGACTGGTCTTGATCGTGGAGCAGATGGTTATATCGTTAAACCATTTGCTATTGAAGAATTACTAGCTCGTGTTCGTGCCATATTTCGTCGTCAAGATATTGAGAAAGCTAAGCATTCTTCTAAAAATGACACTACCTATCGTGATTTGAAATTAGATGTTCATAACCGAGCTGCCATTAGAAATGGTGAGACAATTCCTTTAACTAAACGTGAATTTGATTTATTAAATGCTCTTGTAGAAAATATCAATCAAGTCATGACTAGAGAAGAGCTTTTGGCCCGTGTTTGGAAGTATGATCAAGAAGCTGAAACTAATGTTGTCGATGTTTATATTCGCTATCTTCGTGGGAAGATTGATGTTCCCGGTAAAGAAAGCTATATTCAGACTGTCCGCGGCATGGGGTATATCATTCGCGAAAATAATTAA","5.10","-6.25","26725","MAKDILIIEDEKKLAKFVSLELQHEGYEVEVTYDGRSGLERALEKDFDLILLDLMLPEMDGYEVIRRLQLEKTTYVIIITARDSIMDIVTGLDRGADGYIVKPFAIEELLARVRAIFRRQDIEKAKHSSKNDTTYRDLKLDVHNRAAIRNGETIPLTKREFDLLNALVENINQVMTREELLARVWKYDQEAETNVVDVYIRYLRGKIDVPGKESYIQTVRGMGYIIRENN","1803478","","response regulator for glucan-binding protein","Cytoplasm","This sequence corresponds to the previously published gi6174678 in GenBank. In addition, 1-228 are 75% similar to gi3599371 from S.pyogenes. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1625 (3e-95).","

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[5-118]T$	Response_reg
PF00072	$\"[3-114]T$	Response_reg
SM00448	$\"[3-113]T$	REC
PS50110	$\"[4-117]T$	RESPONSE_REGULATORY

InterPro
IPR001867
Domain

Transcriptional regulatory protein, C-terminal
PD000329	$\"[144-227]T$	Trans_reg_C
PF00486	$\"[151-226]T$	Trans_reg_C

InterPro
IPR005829
Family

Sugar transporter superfamily
PS00217	$\"[89-114]?$	SUGAR_TRANSPORT_2

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[3-193]T$	CheY_like

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[4-139]T$	G3DSA:3.40.50.2300
PTHR23283	$\"[1-121]T$	PTHR23283
PTHR23283:SF21	$\"[1-121]T$	PTHR23283:SF21

InterPro
IPR003772
Family

Protein of unknown function DUF177
PF02620	$\"[7-176]T$	DUF177

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-177 are 46% similar to a (PROTEOME COMPLETE YLBN-LIKE BH2584) protein domain (PD013320) which is seen in Q9F2I3_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:01:13 2002","Mon Mar 11 13:38:10 2002","Tue Oct 8 15:01:13 2002","Mon Mar 11 13:38:10 2002","","Mon Mar 11 13:38:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1749 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 15:01:13 2002","","No significant hits to the NCBI PDB database.","SMU.1925c","","Residues 7 to 176 (E-value = 1.8e-61) place SMu1749 in the DUF177 family which is described as Uncharacterized ACR, COG1399 (PF02620)","Mon Mar 11 13:38:10 2002","24380275","","","","Tue Oct 8 15:01:13 2002","","1","","","SMU.1925c","844" "SMu1750","1805615","1805040","576","ATGTCTAGTTATGAAACCAAAAAAGAAAATACTAAATCTTATCTTCTGGAGGCCTTAGTGGATCTTTTAAAAGAGACGCCATTGAGTCAACTGACCGTGTCTGCTCTAACTCGAAAGGCGGGAGTTTCTAGAGGAACATTTTACCTGCATTATTTGGATATAAACGATTTTATTAAGACAATTGAAGAGAACTTATTTTTAGTCATTGAAGAAAATTTGCAAGATGACCTTTTTTATGACAGTGGTTTAGGTAAACTTCGTTATCTCATTGCTTATGTTGAAAAAAATTATGCTATCTTTCAAATTTTAATCGGAAAAAACGGAGACAAAAATTTTGAACAACGTTTGATTGATCTCATCAAACAATTTATTGTTGGAAATATTGATAAAAATAATCAACATTTCAATATTCCTAAAGATTATATTTTAGATTTGTTGACGATGAGTGTTGTTTCTATTATCTATACTTGGTTTGATGAAGAAACTCCACGGACAAGTCAAGAGATTATTGATATAATAATTAAAACGCGTTTTTTATCACCAGTAGAATTAGTAGGAGAAAAAGTCAATGTTTAA","4.80","-6.51","22154","MSSYETKKENTKSYLLEALVDLLKETPLSQLTVSALTRKAGVSRGTFYLHYLDINDFIKTIEENLFLVIEENLQDDLFYDSGLGKLRYLIAYVEKNYAIFQILIGKNGDKNFEQRLIDLIKQFIVGNIDKNNQHFNIPKDYILDLLTMSVVSIIYTWFDEETPRTSQEIIDIIIKTRFLSPVELVGEKVNV","1805056","For other 'psa' genes see SMu1001 (psaA); SMu1067 (psaB);SMu1068 (psaA); SMu1069 (psaR); SMu1171 (psaR); SMu1231 (psaA) ; SMu1752 (psaB) and SMu1751 (psaA). ","transcriptional regulator PsaR","Cytoplasm","This sequence corresponds to the previously published gi|15625443 in GenBank. In addition, residues 11-175 are 35% similar to gi|15675217 from S.pyogenes.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2135 (9e-12).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[15-51]T$	TetR_N
PS50977	$\"[9-69]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[8-77]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[3-53]T$	Homeodomain-rel

","BeTs to 4 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","No significant hits to the Blocks database.","Residues 5-175 are 25% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD106875) which is seen in Q9KEY0_BACHD.Residues 9-178 are 23% similar to a (HTPG-ALDX) protein domain (PD291723) which is seen in YXBF_BACSU.Residues 11-171 are 27% similar to a (PROTEOME COMPLETE BH3394) protein domain (PD399751) which is seen in Q9K7G7_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 14:53:43 2002","Mon Mar 11 13:43:26 2002","Tue Oct 15 14:53:43 2002","Wed Apr 10 15:12:32 2002","","Mon Mar 11 13:41:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1750 is paralogously related (blast p-value < 1e-3) to SMu1069, SMu1936, SMu1171, SMu0398, SMu0466, SMu1139, and SMu1294, all predicted transcriptional regulators.","Mon Mar 11 13:43:26 2002","","No significant hits to the NCBI PDB database.","SMU.1926c","","Residues 15 to 61 (E-value = 7.4e-05) place SMu1750 in the TetR_N family which is described as Bacterial regulatory proteins, tetR family (PF00440)","Mon Mar 11 13:41:28 2002","","","","","Mon Mar 11 13:43:26 2002","","1","","","SMU.1926c","" "SMu1751","1805723","1806430","708","ATGTCAAACCTTATTAGCTTAAAAGATGTTTATAAAATATACAATGAAAATAAAGAAGACGAGGTCCGTGCCAATAATAAAATCAACTTTACTATTAAAAAGGGGGAATTAACGATTATCGTCGGTAACAGCGGTGCTGGAAAATCAACCCTGCTCAACATTTTAGGCGGTATGGATCAAGCGACTCGCGGACAAGTTCAGATAGGAGAGAAAAATTTAACAGACTTATCAGAAAAAGAACTTACAACTTATCGCCGCTTGGATGTTGGTTTTGTATTTCAATTTTATAATTTAGTTCCCAATTTAACAGCTCTTGAAAACGTTGAACTAGCCAGCGAAGTTGTTAAAGATGTCCTTGATCCGAAGGACGTCTTAGACAATGTCGGCCTTGCCAAACGAACAAACAACTTTCCAGCACAATTGTCCGGTGGTGAACAGCAGCGTGTTTCCATTGCTCGGGCAATGGCCAAGAATCCTAAATTACTATTAGCAGATGAGCCAACTGGTGCCTTGGATTATAAAACAGGTAAGCAGATTTTACAACTCTTTCAAGAATACGTCCGTACAACTGAGAAAAATGTTATTATTGTGACTCATAATTCAATGATCAAGCCGATGGCTGATCATGTTCTTGAAGTATCTGACGGGCAAATCAAGGCAGATTATTACAATGAGAAGCCAATTCCTATTAAAGATTTGGAGTGGTAA","5.50","-2.51","26298","MSNLISLKDVYKIYNENKEDEVRANNKINFTIKKGELTIIVGNSGAGKSTLLNILGGMDQATRGQVQIGEKNLTDLSEKELTTYRRLDVGFVFQFYNLVPNLTALENVELASEVVKDVLDPKDVLDNVGLAKRTNNFPAQLSGGEQQRVSIARAMAKNPKLLLADEPTGALDYKTGKQILQLFQEYVRTTEKNVIIVTHNSMIKPMADHVLEVSDGQIKADYYNEKPIPIKDLEW","1806440","For other components see SMu1752 (MSD1). For other 'psa' genes see SMu1001 (psaA); SMu1067 (psaB);SMu1068 (psaA); SMu1069 (psaR); SMu1171 (psaR); SMu1231 (psaA) ; SMu1752 (psaB) and SMu1750 (psaR). ","PsaA protein/ ABC transporter, ATP-binding protein","Cytoplasm, Membrane","This sequence corresponds to the previously sequenced gi|15625442, a predicted PsaA protein, and paralgously to gi|4098078, a predicted ABC transporter, ATP-binding subunit. See also gi|9802355, gi|15625431, gi|153741, gi|282320, gi|547928, >gi|15625436, gi|4322367|, >gi|9802352, gi|9802002, gi|4103630, gi|5918764, gi|3152919, gi|2062756, gi|2492598, gi|2952525, gi|8925937, gi|3399707, >gi|7430357, >gi|1661187, gi|2492547, gi|9802003.No other matches in gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1004 (2e-70).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[140-182]T$	ABC_transporter
PF00005	$\"[35-216]T$	ABC_tran
PS00211	$\"[141-155]T$	ABC_TRANSPORTER_1
PS50893	$\"[5-235]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[34-217]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-218]T$	G3DSA:3.40.50.300
PTHR19222	$\"[5-218]T$	PTHR19222
PTHR19222:SF32	$\"[5-218]T$	PTHR19222:SF32
SSF52540	$\"[1-218]T$	SSF52540

","BeTs to 14 clades of COG1136COG name: ABC-type (unclassified) transport system, ATPase componentFunctional Class: RThe phylogenetic pattern of COG1136 is AMt--QVCEBRHUJGPOLinxNumber of proteins in this genome belonging to this COG is 8","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.6e-37. IPB001140A 24-70 IPB001140B 138-176 IPB001140C 193-222","Residues 77-113 are 86% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000230) which is seen in Q9CGJ3_LACLA.Residues 128-229 are 29% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in YN26_MYCTU.Residues 26-75 are 56% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CGJ3_LACLA.Residues 140-182 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CGJ3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:33:26 2002","Mon Mar 11 14:53:08 2002","Tue Oct 15 14:51:16 2002","Fri Mar 8 18:46:36 2002","Fri Mar 8 18:46:36 2002","Fri Mar 8 18:46:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1751 is paralogously related (blast p-value < 1e-3) to SMu1068, SMu1246, SMu1231, SMu1288, SMu0786, SMu1210, SMu1001, SMu0916, SMu1380, SMu1762, SMu1003, SMu0517, SMu0418, SMu0849, SMu0971, SMu0594, SMu0731, SMu1920, SMu0234, SMu0218, SMu0884, SMu1079, SMu1023, SMu0235, SMu0390, SMu1428, SMu1950, SMu1949, SMu0805, SMu1316, SMu0907, SMu1757, SMu1065, SMu0216, SMu1649, SMu0836, SMu0335, SMu0987, SMu0475, SMu0258, SMu0824, SMu1064, SMu1517, SMu1036, SMu1710, SMu0596, SMu0024, SMu1037, SMu1518, SMu1545, SMu0825, SMu0374, SMu1811, SMu0986, SMu1724, SMu0944, SMu1959, SMu1050, SMu1410, SMu0823, SMu0837, SMu0752, SMu0164, SMu0950, SMu0476, SMu0976, SMu1306, SMu0224, SMu1093, SMu0729, SMu1686, SMu1202, and SMu0666, mostly ABC transporter, ATP-binding proteins.","Mon Mar 11 14:51:35 2002","Fri Mar 8 18:46:36 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 109 4e-025pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 101 9e-023","SMU.1927","","Residues 35 to 216 (E-value = 6.9e-52) place SMu1751 in the ABC_tran family which is described as ABC transporter (PF00005)","Fri Mar 8 18:46:36 2002","24380277","","","","Tue Oct 29 09:21:30 2002","","1","","","SMU.1927","" "SMu1752","1806432","1809044","2613","ATGAAAACATTAACAAAAAATATTTTCCGTACATTTAGACGGACTTGGGCACGCTTTTTATCGGTAAGCTTATTGATTGGTCTTGCTATTTTTGTTTTTGTTGGACTCTTCTCAGCTGGGCCTGATATGCGGCAAACCGTCATTAGGCAATTTAAAAAAGAAAATTTAGCTGATGTTCAGGTTATAGCCAGTGATAAATTTACCGATGCTGATAAAAAGACACTCAATCATATCCATGGTATTCGTGCAATTTCCTATGGCAAGCAAACTGATGCTGAACTGGCTGACAAGGGTATTCATATCATCAGCAATCCTAAAAATATCTCAACTTTAAAAGTTATCAAAGGACGGCTAGCAAACTCTAATGATGAGATCGCCATTGGCGAACAGTTCCATAAAAACATTGGTGAGTACATTACGCTTAAAACGAACGATTTGAAGATAAAAAAAGTGAAAATTGTTGGTATAGTCCGTACATCTGAATTTATGTCTAAAACTAAGTTAGGACAAACAAATGTTGCCGATGGAACCTTAAGTTACTTTGCTGTTATGCCTGACTCCAATTTTACTATTTCAGACAATCTTGCACGTGCTACTTTTAAAAATACCAAATACAAAAAAGCCTATACCAAAAACTATTCAGATACTGTCTCTGAAAATATCGAAAAATTGGAACGGGTCACGCAAAAGCTGACTAAAAAGAATCAAGAACAAGCTTTAGCAGATATTTCAAAAAAAGAAGAAAACCTTAAAATGGCTGAGGTAACGCTCAAACAAAAAGAACTTCAGCTTAAAGAAAATGAGGTTCAACTCAATGTAACTGCCCAAACTGCAACTTCTTATCAAGCTCAACTTCAAATAGCTAATCAAAACGCTCAGCTTCAACAAGAAAAGGATAAATTAAAAAAGCTTAAGACAGATTTAGCTCAGAAAAAAATAAACTTGAAGAAGGCAAAAAAACAAGTTAGCCTTTTAAGCATTACTGTTCAAGAACGCTCTCAGTTTGCTCATGGTTACTCTGATTACGGCAGTTCGGCAACACGAATGGATGCCTTGGCACTCGTACTTCCCGTTATTTTCTTTGCTATTTCGCTTATGGTATCCTTTACCACCATGAGACGCATGGTAACAGAAAAACGTATTGAATTGGGGACATTGCGAGCTCTTGGTTTTACTAGAAAAGAGGTCATGCGGGAGTACATCCTCTATAGCACAGCAACAGCTATTTTGGGTACATTCTTTGGGAGTTTATTAGGAACCTTCTTCCTACCAAGCAGGATCTACAATATTTTTGCCGATGGTTCTTATCAGCTAGGTAACATAACCTTTGTCTATAACATCCCTCTTCTTCTAATTTCACTGGCTCTTTCTCTTGTGAGTACGCTCTTTGCAGCCTACTGGGCAGCCAGACAAGAACTCAAGGAAAAACCAAGTAGTCTTATGCTAGCTAAACCACCAGCAATCACCAACAAAATTTTTCTGGAACGCCTTACCTTTATTTGGAAAAAACTTTCCTTCTCAAATAAAGTGACACTTCGTAATGCCTTTCGTTATAAATCGCGTATGTTTATGACTATTTTTGGTGTTATGGGGTCTATTTCCCTACTGATTTTAGGAATCGGCATCAGGGATAGTTTGATAGAACTTGTCCCCAGCCAATACGAGCATATTTCAGCTTATGACATGATTGCAGTTTACAATCCTGGTTCTTCTAATGTGGCTTCTTACCAAAAGATTATTAAGAACGATGCCAATCATGAACTTGCTATCGGCTATGAGACCTTTTACGCCAAATCCAAAGAGCTTCTTGATAGCCAATCTATCCAAGCTTTCACTGCTAATAACTTTAAAGACTATATCAAGTTAGATAAAGAGCCAACTGCAGACGGTGCTATCTTGTCACAAAAATTAGCACATGCCTTCCATTTAAAAGTAGGTGACAAACTGACTGTCAAAAATAGTGAAGGAAAATCGTATCATATTAAAGTCGCAGGCTTTACAACAAATTATGTTGGCCATATGATTTACATGAAACCAAGTTACCATGAAAAAGTCTTTCATGAAAAGTACGAAAACAATGCTTATTTGATTAGAACCAAAAAGAATATTGAAAACCAAAACCTAGCAGAAAAAATCAATAAAAACAAAGCGAGTCTAACTATCGTTAAAAGCAAAGTCCTTCGTCAAACAATCAGTGATTTCCTAAATGGCTTAACTAACATTATCTTAATTATTATTTTTGTTTCTATTATGCTAGCTTTTATCGTTCTTTATACTCTAACAAGTATCAATGTCGCTGAGCGGGAAAAGGAATTAGCAACCATCAAAGTTTTGGGCTTTTATCAAAAAGAAGCTCTCATGTATATCTTTAAAGAGACCTTCCTTCTGACAGCTATCGGTATTTTATCTGGTTTAGCTCTAGGTTACTTCATTCATAAATACGTTATGACTGTTATTCCTCCTGAATATGTCATGTCAATCCCCGGTATCACTTGGACTAATATCCTTATATCATCTGGAGCTGTTTTCTTCTTTACTTTTATTGTTATGATTATTATGAATCGACACATTAGAAAAATTGATATGTTAGAGGCTTTAAAATCAGTTGATTAA","10.60","46.66","98556","MKTLTKNIFRTFRRTWARFLSVSLLIGLAIFVFVGLFSAGPDMRQTVIRQFKKENLADVQVIASDKFTDADKKTLNHIHGIRAISYGKQTDAELADKGIHIISNPKNISTLKVIKGRLANSNDEIAIGEQFHKNIGEYITLKTNDLKIKKVKIVGIVRTSEFMSKTKLGQTNVADGTLSYFAVMPDSNFTISDNLARATFKNTKYKKAYTKNYSDTVSENIEKLERVTQKLTKKNQEQALADISKKEENLKMAEVTLKQKELQLKENEVQLNVTAQTATSYQAQLQIANQNAQLQQEKDKLKKLKTDLAQKKINLKKAKKQVSLLSITVQERSQFAHGYSDYGSSATRMDALALVLPVIFFAISLMVSFTTMRRMVTEKRIELGTLRALGFTRKEVMREYILYSTATAILGTFFGSLLGTFFLPSRIYNIFADGSYQLGNITFVYNIPLLLISLALSLVSTLFAAYWAARQELKEKPSSLMLAKPPAITNKIFLERLTFIWKKLSFSNKVTLRNAFRYKSRMFMTIFGVMGSISLLILGIGIRDSLIELVPSQYEHISAYDMIAVYNPGSSNVASYQKIIKNDANHELAIGYETFYAKSKELLDSQSIQAFTANNFKDYIKLDKEPTADGAILSQKLAHAFHLKVGDKLTVKNSEGKSYHIKVAGFTTNYVGHMIYMKPSYHEKVFHEKYENNAYLIRTKKNIENQNLAEKINKNKASLTIVKSKVLRQTISDFLNGLTNIILIIIFVSIMLAFIVLYTLTSINVAEREKELATIKVLGFYQKEALMYIFKETFLLTAIGILSGLALGYFIHKYVMTVIPPEYVMSIPGITWTNILISSGAVFFFTFIVMIIMNRHIRKIDMLEALKSVD","1809054","For other components see SMu1751 (NBD1).For other 'psa' genes see SMu1001 (psaA); SMu1067 (psaB);SMu1068 (psaA); SMu1069 (psaR); SMu1171 (psaR); SMu1231 (psaA) ; SMu1750 (psaR) and SMu1751 (psaA). ","protein secretion ABC transport permease","Membrane, Cytoplasm, Extracellular","Smu1752 was previously sequenced and submitted to GenBank as protein secretion ABC transport permease PsaB (gi:15625441) by Tao,L. and Tanzer,J.M.Several strong hits in gapped BLAST to an ABC transporter protein and conserved hypothetical proteins; residues 2-870 are 30% similar to ABC transporter permease protein of Lactococcus lactis (gi|15673086).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1003 (1e-90).","

InterPro
IPR003838
Domain

Protein of unknown function DUF214, permase predicted
PF02687	$\"[278-477]T$ $\"[692-862]T$	FtsX

","BeTs to 9 clades of COG0577COG name: Predicted permeaseFunctional Class: RThe phylogenetic pattern of COG0577 is AMt--QVcEBRHuj--OLinxNumber of proteins in this genome belonging to this COG is 7","***** IPB003838 (DUF214) with a combined E-value of 5.8e-09. IPB003838A 368-415 IPB003838A 757-804","Residues 2-271 are 27% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD401701) which is seen in Q9CGJ2_LACLA.Residues 338-839 are 35% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD147912) which is seen in Q9CGJ2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 11:24:07 2002","Fri Mar 8 18:13:55 2002","Tue Oct 15 14:50:19 2002","Fri Mar 8 18:13:55 2002","Fri Mar 8 18:13:55 2002","Fri Mar 8 18:13:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1752 is paralogously related (blast p-value < 1e-3) to SMu1067, ABC transporter permease protein, SMu1245, ABC transporter permease protein, SMu1230, ABC transporter permease protein, SMu1288, ABC transporter membrane protein subunit, SMu1000, ABC transporter permease protein, SMu1031, histidine kinase, and SMu0917, ABC transporter permease and substrate binding protein.","Fri Mar 8 18:17:45 2002","","No significant hits to the NCBI PDB database.","SMU.1928","","Residues 278 to 477 (E-value = 2.9e-28) place SMu1752 in the FtsX family which is described as Predicted permease (PF02687)Residues 692 to 862 (E-value = 1.5e-25) place SMu1752 in the FtsX family which is described as Predicted permease (PF02687)","Fri Mar 8 18:13:55 2002","24380278","","","","Mon Oct 28 11:24:07 2002","","1","","","SMU.1928","" "SMu1753","1810080","1809181","900","ATGCTATTTAATCAAATTGCTAGCAATAAAAGAAAAACAATCGTTCTTCTGATTGTTTTCTTTATGCTTTTAGCTGCTATTGGTGCGGCAGTCGGTTATCTCTGGTTGGATAGTTTGGTAGGCGGCATGGCTATTGCTTTGATTATCGGCTTTATTTATGCCTTTAGTATGATTTTTCAGTCAACCAATATTGTCATGGCCATGAATAATGCCAAAGAAATTACAGTAGATGAAATGCCAGACTATTATCATATTGTTGAGGATATGGCTATGGTGGCACAAATCCCTATGCCCCGTGTTTATGTGATTGACGATCCTTCGCTCAATGCTTTTGCTACAGGATCCAGTCCCCAAAATGCTGCAGTGGCTGCAACCACTGGACTCTTAGCTATTATGAATCGTGAAGAATTAGAAGGCGTTATTGGGCATGAGGTTAGTCATATCAGGAATTATGACATTCGAATTTCAACTATTGCTGTTGCTCTTGCTAGTGCTGTCACCTTGATTTCGAGTATAGGCGGTCGAATGATGTGGTTTGGTGGCGGCAGGAGCCGCCGTTCAAATGATAATGAAGGCGGCGGTTACCTACAAATTATCCTTCTTATTTTTTCTCTTCTGGCCATTATCTTAGCTCCTTTGGCAGCCAGTCTTGTTCAATTAGCTATTTCACGTCAGCGAGAATATTTGGCAGATGCCAGTTCTGTTGAACTAACACGCAATCCGCAAGGAATGATTAGGGCTCTGCAAAAATTAGAACAGTCTCAGCCCATGGCTCACTCTGTTGATAATGCCAGTGCTGCGCTATATATCAATGATCCTAAGAAAAAATCGGGTTTAAAGCACCTTTTTTATACTCATCCGCCAATTGCTGATAGAATTAGACGTTTAGAACAAGTGTAG","7.90","1.44","32712","MLFNQIASNKRKTIVLLIVFFMLLAAIGAAVGYLWLDSLVGGMAIALIIGFIYAFSMIFQSTNIVMAMNNAKEITVDEMPDYYHIVEDMAMVAQIPMPRVYVIDDPSLNAFATGSSPQNAAVAATTGLLAIMNREELEGVIGHEVSHIRNYDIRISTIAVALASAVTLISSIGGRMMWFGGGRSRRSNDNEGGGYLQIILLIFSLLAIILAPLAASLVQLAISRQREYLADASSVELTRNPQGMIRALQKLEQSQPMAHSVDNASAALYINDPKKKSGLKHLFYTHPPIADRIRRLEQV","1809197","","protease HtpX-like protein; heat shock protein","Membrane, Cytoplasm, Extracellular","Smu1753 was previously sequenced and submitted to GenBank as protease HtpX-like protein (gi:15625440) by Tao,L. and Tanzer,J.M.Several strong hits to HtpX heat shock proteins; residues 1-299 are 67% similar to putative heat shock protein of Streptococcus pyogenes (gi15674492), residues 1-299 are 68% similar to heat shock protein HtpX of Streptococcus pneumoniae (gi15901143).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1627 (1e-119).","

InterPro
IPR001915
Family

Peptidase M48, Ste24p
PF01435	$\"[86-297]T$	Peptidase_M48

noIPR
unintegrated

unintegrated
PTHR10120	$\"[86-299]T$	PTHR10120

","BeTs to 11 clades of COG0501COG name: Predicted Zn-dependent proteases (possible chaperone function)Functional Class: OThe phylogenetic pattern of COG0501 is AmTKYQ-CEBRhUJ-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 8-83 are 57% similar to a (PROTEASE 3.4.24.- HOMOLOG HYDROLASE) protein domain (PD336378) which is seen in HTPX_STRGC.Residues 158-251 are 60% similar to a (HYDROLASE HOMOLOG PROTEASE TRANSMEMBRANE) protein domain (PD290110) which is seen in HTPX_STRGC.Residues 266-299 are 67% similar to a (HYDROLASE HOMOLOG PROTEASE TRANSMEMBRANE) protein domain (PD334160) which is seen in HTPX_STRGC.Residues 89-148 are 85% similar to a (COMPLETE PROTEOME PROTEASE) protein domain (PD002296) which is seen in HTPX_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 14:49:29 2002","Mon Sep 18 15:17:42 2006","Mon Sep 18 15:17:42 2006","Fri Mar 8 18:03:45 2002","","Fri Mar 8 18:03:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1753 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 15 14:49:29 2002","","No significant hits to the NCBI PDB database.","SMU.1929c","","Residues 86 to 299 (E-value = 3.8e-21) place SMu1753 in the Peptidase_M48 family which is described as Peptidase family M48 (PF01435)","Fri Mar 8 18:03:45 2002","","","","Shimohata N, Chiba S, Saikawa N, Ito K, Akiyama Y.The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membraneprotease with a cytosolic active site.Genes Cells. 2002 Jul;7(7):653-62.PMID: 12081643Vickerman MM, Mather NM, Minick PE, Edwards CA.Initial characterization of the Streptococcus gordonii htpX gene.Oral Microbiol Immunol. 2002 Feb;17(1):22-31.PMID: 11860552 Kornitzer D, Teff D, Altuvia S, Oppenheim AB.Isolation, characterization, and sequence of an Escherichia coli heat shock gene, htpX.J Bacteriol. 1991 May;173(9):2944-53.PMID: 1826904 ","Mon Sep 18 15:17:42 2006","Thu Oct 24 13:16:39 2002","1","","","SMU.1929c","448" "SMu1754","1810650","1810090","561","ATGTTGATTTGGATTATTTTAGTTATTGTCATCCTTCTTGTGATTTGGGTGACTGTCGGTTATAATGGCCTTGTAAGAAGCCGTATGCAAACGCAAGAGGCTTGGAGTCAGATTGATGTTCAGTTGAAACGCCGCAATGATTTGATTCCTAATTTGCTTGAAACAGTCAAAGGTTATGCTAAGTATGAACAAAGCACTTTAGAAAAAGTAACCGAACTGCGCAGTAAGGTAGCCAATGCCAGTACGCCTAATGAAGCTATGAAAGCTAGTGATGCTCTCGGAAAACAAATGGCTAGTATTTTAGCAGTTGCAGAAAGTTATCCTGATCTCAAAGCAAATCAAAATTTTCTTAAGTTGCAAGAAGAACTGACAAATACAGAAAATAAAATTTCTTATTCACGTCAACTTTTCAATTCAACCACAGCTAACTACAATGTTAAGTTAGAAACCTTTCCAAGTAATCTTATTGCTGGTTTATTTGGTTTTAAGGCTAAGGAATTTTTAGAAACACCAGAAGAAGAAAAATCAGTGCCAAAAGTGGACTTTGGAGATATGGCTTAG","5.50","-1.00","20995","MLIWIILVIVILLVIWVTVGYNGLVRSRMQTQEAWSQIDVQLKRRNDLIPNLLETVKGYAKYEQSTLEKVTELRSKVANASTPNEAMKASDALGKQMASILAVAESYPDLKANQNFLKLQEELTNTENKISYSRQLFNSTTANYNVKLETFPSNLIAGLFGFKAKEFLETPEEEKSVPKVDFGDMA","1810106","","LemA-like protein","Membrane, Cytoplasm","Smu1754 was previously sequenced and submitted to GenBank as LemA-like protein (gi15625439) by Tao,L. and Tanzer,J.M.Many hits in gapped BLAST to LemA proteins; residues 19-185 are 79% similar to lemA protein, Cytoplasmic membrane protein, of Streptococcus pneumoniae (gi15901144), residues 19-182 are 75% similar to putative cytoplasmic membrane protein of Streptococcus pyogenes (gi15674491).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1628 (5e-70).","

InterPro
IPR007156
Family

LemA
PF04011	$\"[1-182]T$	LemA

noIPR
unintegrated

unintegrated
PD024065	$\"[53-174]T$	PD024065

","BeTs to 3 clades of COG1704COG name: Uncharacterized ACR, LemA familyFunctional Class: SThe phylogenetic pattern of COG1704 is -m----v----------l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 21-182 are 77% similar to a (PROTEOME COMPLETE LEMA 5'REGION) protein domain (PD022603) which is seen in Q9FA50_STRGN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 8 17:48:18 2002","Fri Mar 8 17:37:52 2002","Fri Aug 18 14:34:17 2006","Fri Mar 8 17:37:52 2002","","Fri Aug 18 14:34:17 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1754 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 8 17:48:18 2002","","No significant hits to the NCBI PDB database.","SMU.1930c","","Residues 1 to 182 (E-value = 2.6e-99) place SMu1754 in the LemA family which is described as LemA family (PF04011)","Fri Mar 8 17:37:52 2002","","","","","Fri Aug 18 14:34:17 2006","","1","","","SMU.1930c","715" "SMu1755","1810738","1811451","714","ATGACCCCTGAAGAATTTTACCAAGCTTTGGCCAAACATCACATCAACTTATCTGCTAAACAAAAAGAACAATTTGACCTTTATTTTAAATTATTGGTGGAATGGAATGATAAAATCAATCTTACTGCCATTACTGAGGAAAAAGAAGTCTATCTTAAACATTTCTATGACTCTATAGCACCACTTTTATCAGGCTATATTCCTAATGAGTCTTTAAAACTTTTGGACATTGGGGCAGGAGCTGGTTTTCCTAGTCTACCAATGAAAATTATTTATCCCCAGTTAGACGTCACTATCATTGACTCACTGAATAAGCGTATTAAATTTCTTAATTTATTAGCTGATGCTTTAGAACTTGACAAGGTTCATTTTTACCATGGCAGGGCTGAAGTTTTTGGACAAGACAAGAATTTTCGAGCTCACTTTGACCTTGTTACGGCCAGAGCTGTCGCTCGTTTACAAGTGTTATCCGAACTCACTATTCCCTTTTTAAAAGTCGGCGGTCAATTGCTTGCTCTTAAAGCCAGTGCTGCTGACGAAGAATTAAAAACTGCTCAAAATGCTTTAAACTTATTGTTTAGTCAAACAACTAGCAGTGACAACTATCAACTTCCCAATGGAGACGGACGCAATCTCACTATTATCACTAAAAAGAAAGAAACACCGAATAAATATCCACGTAAGGCTGGAATGCCTAACAAAAAACCTTTGTAG","9.70","4.45","26758","MTPEEFYQALAKHHINLSAKQKEQFDLYFKLLVEWNDKINLTAITEEKEVYLKHFYDSIAPLLSGYIPNESLKLLDIGAGAGFPSLPMKIIYPQLDVTIIDSLNKRIKFLNLLADALELDKVHFYHGRAEVFGQDKNFRAHFDLVTARAVARLQVLSELTIPFLKVGGQLLALKASAADEELKTAQNALNLLFSQTTSSDNYQLPNGDGRNLTIITKKKETPNKYPRKAGMPNKKPL","1811461","For other 'gid' genes see SMu1943 (gidA) and SMu0913 (gidA) , (gid).","glucose-inhibited division protein","Cytoplasm","Smu1755 was previously sequenced and submitted to GenBank as putative glucose-inhibited division protein, GidB, (gi:15625438) by Tao,L. and Tanzer,J.M.Many strong hits in gapped BLAST to glucose-inhibited division protein; residues 1-237 are 73% similar to glucose-inhibited division protein of Streptococcus pyogenes (gi|15674490), residues 1-237 are 74% similar to glucose inhibited division protein B of Streptococcus pneumoniae (gi|15903207).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1629 (1e-101).","

InterPro
IPR003682
Family

Glucose inhibited division protein
PD004441	$\"[30-99]T$	GidB
PF02527	$\"[21-204]T$	GidB
TIGR00138	$\"[25-217]T$	gidB

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[4-237]T$	G3DSA:3.40.50.150
SSF53335	$\"[2-221]T$	SSF53335

","BeTs to 11 clades of COG0357COG name: Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell divisionFunctional Class: MThe phylogenetic pattern of COG0357 is -----qvcebrhujgpol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB003682 (Glucose inhibited division protein) with a combined E-value of 4.4e-40. IPB003682A 32-59 IPB003682B 76-101 IPB003682C 142-182","Residues 28-182 are 70% similar to a (DIVISION INHIBITED GLUCOSE PROTEOME) protein domain (PD004441) which is seen in GIDB_LACLA.Residues 185-237 are 50% similar to a (INHIBITED GLUCOSE DIVISION PROTEOME) protein domain (PD101293) which is seen in GIDB_LACLA.Residues 73-237 are 37% similar to a (B GLUCOSE DIVISION INHIBITED) protein domain (PD101295) which is seen in Q9LCY2_THETH.Residues 25-204 are 28% similar to a (B GLUCOSE DIVISION INHIBITED) protein domain (PD230733) which is seen in GIDB_MYCGE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 13:46:20 2002","Fri Mar 8 17:27:27 2002","Tue Oct 15 13:46:20 2002","Fri Mar 8 17:27:27 2002","Fri Mar 8 17:27:27 2002","Fri Mar 8 17:27:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1755 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 2 14:41:12 2002","","No significant hits to the NCBI PDB database.","SMU.1931","","Residues 21 to 204 (E-value = 2.3e-55) place SMu1755 in the GidB family which is described as Glucose inhibited division protein (PF02527)","Fri Mar 8 17:27:27 2002","24380281","","","","Tue Apr 2 14:41:12 2002","","1","","","SMU.1931","449" "SMu1756","1812508","1811675","834","ATGAATAAACCCTTAATTGGCTATCATGATGGTCAAGGTTTTCTCTACAAGCTATCAGGTGCTAGTAAACTACTTTTCTTTCTCCTTGTTTCTATTGCTTGTATGACAACCTATGATACGCGTTTAATTGCAGCAGTAGGTATCCTTTCAATCTTTCTCTTTAAAATGGCAGACATTCATTGGCGGGACATTTCTTTTGTCATGAAATTCATAACCGTATTTGCGGTTTTGAATGTTGTCATGGTTTATCTTTTTGCACCTGATTATGGAGAAAAAATTTATGGAGCAAAGACCTTATTATTTGAAGGATTTGGTGGATTTTACTTAAGCAGTCAGGAAATCTTTTATCTTTTAAATTTAGTTCTCAAGTATTTCTGTACAGTCCCTCTGGCTATTTTATTTTTGATGACGACTCATCCTAGTCAATTTGCTTCCAGTCTCAATCAAATTGGGGTTCCTTATAAAATAGCCTACGCTGTTAGTTTAACGTTGCGTTATATTCCTGATGTTCAGGAAGAATTTTATATGATTCGAACTTCACAGGAAGCGCGTGGATTGGAATTATCAAAAAAGGCCAGATTAATGAGTCGTATTAAAGGGAATGTTCAAATTATTGTTCCGCTCATTTTCAGCTCCTTGGATAGAATAGATACCATTTCCACTGCCATGGAACTTCGTCGTTTTGGCAAAAACAAGAAGAGAACTTGGTATACTTATCAGCCTTTTAGAAAAAATGACTTTCTTACTATATTTCTAGCCTGTTTGATTTTACTAATCAGTCTAAGTTTATTTGCTCTTAATAAAGGACGATTTTATAACCCATGGGCAGGTTAA","10.40","13.57","31791","MNKPLIGYHDGQGFLYKLSGASKLLFFLLVSIACMTTYDTRLIAAVGILSIFLFKMADIHWRDISFVMKFITVFAVLNVVMVYLFAPDYGEKIYGAKTLLFEGFGGFYLSSQEIFYLLNLVLKYFCTVPLAILFLMTTHPSQFASSLNQIGVPYKIAYAVSLTLRYIPDVQEEFYMIRTSQEARGLELSKKARLMSRIKGNVQIIVPLIFSSLDRIDTISTAMELRRFGKNKKRTWYTYQPFRKNDFLTIFLACLILLISLSLFALNKGRFYNPWAG","1811691","For other components see SMu1757 (NBD1 and NBD2) and SMu1758 (MSD2).","cobalt ABC transporter permease","Membrane, Cytoplasm","Smu1756 was previously sequenced and submitted to GenBank as ABC transport permease (gi:15625437) by Tao,L. and Tanzer,J.M.Several moderate hits in gapped BLAST to ABC transporter permeases; residues 1-275 are 63% similar to ABC transporter membrane-spanning permease - unknown substrate of Streptococcus pneumoniae (gi15902475), residues 5-275 are 53% similar to ABC transporter permease protein of Lactococcus lactis (gi15672308).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1632 (1e-108).","

InterPro
IPR003339
Family

Cobalt transport protein
PF02361	$\"[11-237]T$	CbiQ

noIPR
unintegrated

unintegrated
PS51257	$\"[1-34]T$	PROKAR_LIPOPROTEIN

","BeTs to 9 clades of COG0619COG name: Cobalt permease and related transportersFunctional Class: PThe phylogenetic pattern of COG0619 is AMTk--vC-Brh--GP-----Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 43-250 are 56% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD112638) which is seen in Q9CIN0_LACLA.Residues 5-41 are 56% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD376658) which is seen in Q9CIN0_LACLA.Residues 109-228 are 26% similar to a (PROTEOME COMPLETE TRANSMEMBRANE MG302) protein domain (PD220051) which is seen in Q9CIS7_LACLA.Residues 22-240 are 23% similar to a (DOMAIN OF UNKNO N) protein domain (PD237849) which is seen in Q9WW91_LACLC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:14:17 2002","Mon Sep 18 15:33:36 2006","Mon Sep 18 15:33:36 2006","Fri Mar 8 17:19:36 2002","","Fri Mar 8 17:19:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1756 is paralogously related (blast p-value < 1e-3) to SMu1948, probable ABC transporter membrane-spanning permease.","Thu Apr 25 17:37:20 2002","","No significant hits to the NCBI PDB database.","SMU.1933c","","Residues 11 to 237 (E-value = 2.3e-18) place SMu1756 in the CbiQ family which is described as Cobalt transport protein (PF02361)","Fri Mar 8 17:19:36 2002","24380282","","","","Mon Oct 28 13:14:17 2002","","1","","","SMU.1933c","450" "SMu1757","1814177","1812501","1677","ATGAAACCATTTATTGAATTCAAGGATTTTTCTTTTAAATATGATGCTCAGGCAGAGCCAACCTTGAAAGAAATCACACTTTCTATTGAGAAAGGGGAAAAGGTACTGATTATTGGGCCGTCTGGAAGTGGAAAGTCAACCATAGGGCACTGTTTAAATGGCATTATTCCTAATATTTATAAAGGGCAGGCTGAAGGTTCTTTGACAATAGATGGCAAGGATGTCTTTGATCTATCTATTTATGAAAAATCTCATCTTGTTTCAACTGTTTTACAAGATCCAGATGGGCAATTTATTGGCTTAACAGTAGCAGAAGATCTTGCTTTTGCCTTGGAAAATGATTGTGTAGCCCATGAGACAATGTTTGAGAGGGTGGACACTTGGGCAGACAAATTAGATTTAAAAGAATTGCTCCAACATCGTCCGCAGGATTTATCAGGCGGACAAAAGCAAAGAGTCAGTTTGGCAGGTGTTATGATTGATGAAAGTCCTGTTTTATTATTTGACGAACCTTTAGCTAATCTAGATCCAAAATCTGGTCAGGACACCATAGATTTGATTGATCATCTTCATCAGACGGCAGAAACAACTACTATTATTATTGAACATCGCTTAGAAGATGTTCTTTATCGACCTGTTGATCGGGTTATACTGATTAATGAAGGTCAAGTTCTTTTTAACGGAAGTCCTAATGATCTTTTAAAGACTAGTCTTTTACAAGAAAATGGTATTCGTGAGCCCCTTTATGTGACTGTTTTACGTCATCTTGGTTTGGATATCAAAAATACTTCTCATTTAGCCAATCTTGAACAACTTGATCTCTCTGGTGTCAGTTTTGCAGGCGATATTTCCCTAAAAGAACCTCAAGAGCCACAAGTCTTGTTTGATATTCAACACCTTAATTTTGCCTATAGTTCAGAGCGTCCCATTTTGAAGAATCTCTCTTTTACCCTTAATAAGGGGGAACGTCTTGCTATTGTTGGCAAAAATGGTGCAGGTAAATCAACGCTGGCCAAAGCTCTTTGTCAGTTTATTTCCTACGCTGGCCAAATCTTTTATCAAGGCCAGGATATTGCATCTGATTCTATCAAGGAACGCTCCGAGCGTATTGGCTATGTTCTCCAAAATCCTAATCAAATGATTAGTCAAACGATGATTTTTGATGAAGTTGCTCTGGGACTCCGTTTACGCGGTGTTGATGACAGTCAGATCGAAAAGCGCGTTTTGAAGGTTTTAAAGACCTGCGGTCTTTATGAGTTTCGCAAGTGGCCCATTTCAGCCCTTTCCTTCGGGCAGAAAAAACGCGTGACCATTGCTTCTATTTTGGTATTGAATCCAGAGGTGATTCTTTTAGATGAACCGACAGCAGGACAAGATAAGAAGCATTATACAGAAATGATGTCTTTCTTAAATGATTTGCATGCTTTGGGGCATACTATTATTATGATTACACATGATATGCAACTCATGTTAGAATATTCTGATCGAGCCTTGGTTATTAGTGATGGTCAAATTCTAGCTGATCAAAGTCCCATTACTCTCTTTAATCAACCGGACATACTAAGAATAGCCAATCTTAAACAAACTAGCATTTTTGATTTGGCGCAAAGACTGAATTGTGACCCAATTGCTCTGACACATTACTATATTGATCAGCAAGGAGGAGAAGATGAATAA","4.80","-23.57","62377","MKPFIEFKDFSFKYDAQAEPTLKEITLSIEKGEKVLIIGPSGSGKSTIGHCLNGIIPNIYKGQAEGSLTIDGKDVFDLSIYEKSHLVSTVLQDPDGQFIGLTVAEDLAFALENDCVAHETMFERVDTWADKLDLKELLQHRPQDLSGGQKQRVSLAGVMIDESPVLLFDEPLANLDPKSGQDTIDLIDHLHQTAETTTIIIEHRLEDVLYRPVDRVILINEGQVLFNGSPNDLLKTSLLQENGIREPLYVTVLRHLGLDIKNTSHLANLEQLDLSGVSFAGDISLKEPQEPQVLFDIQHLNFAYSSERPILKNLSFTLNKGERLAIVGKNGAGKSTLAKALCQFISYAGQIFYQGQDIASDSIKERSERIGYVLQNPNQMISQTMIFDEVALGLRLRGVDDSQIEKRVLKVLKTCGLYEFRKWPISALSFGQKKRVTIASILVLNPEVILLDEPTAGQDKKHYTEMMSFLNDLHALGHTIIMITHDMQLMLEYSDRALVISDGQILADQSPITLFNQPDILRIANLKQTSIFDLAQRLNCDPIALTHYYIDQQGGEDE","1812517","For other components see SMu1756 (MSD1) and SMu1758 (MSD2). ","cation ABC transport ATP-binding protein","Cytoplasm, Membrane","This sequence corresponds to the previously sequenced gi|15625436 in GenBank, a predicted SdcBA ABC transport ATP-binding protein, submitted by Tao,L. and Tanzer,J.M.Many strong hits in gapped BLAST; residues 5-555 are 66% similar to ABC transporter ATP-binding protein - cobalt transport of Streptococcus pneumoniae(gi|15902474), residues 1-556 are 52% similar to of Lactococcus lactis (gi|15672307).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1633 (0.0).","

InterPro
IPR000767
Family

Disease resistance protein
PR00364	$\"[34-49]T$ $\"[264-280]T$	DISEASERSIST

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[145-187]T$ $\"[428-470]T$	ABC_transporter
PF00005	$\"[32-222]T$ $\"[321-503]T$	ABC_tran
PS00211	$\"[145-159]T$ $\"[428-442]T$	ABC_TRANSPORTER_1
PS50893	$\"[5-246]T$ $\"[295-527]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[31-223]T$ $\"[320-504]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[2-236]T$ $\"[288-531]T$	G3DSA:3.40.50.300
PTHR19222	$\"[295-534]T$	PTHR19222
PTHR19222:SF22	$\"[295-534]T$	PTHR19222:SF22
SSF52540	$\"[3-235]T$ $\"[294-551]T$	SSF52540

","BeTs to 7 clades of COG1122COG name: ABC-type cobalt transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1122 is AMTK--VC-Brh--GP-l---Number of proteins in this genome belonging to this COG is 3","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.4e-22. IPB001140A 310-356 IPB001140B 425-463 IPB001140C 480-509***** PR00364 (Disease resistance protein signature) with a combined E-value of 2.4e-06. PR00364A 34-49 PR00364D 264-280","Residues 5-234 are 28% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD313900) which is seen in Q9WZT4_THEMA.Residues 360-427 are 60% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD387940) which is seen in Q9CIN1_LACLA.Residues 479-556 are 46% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD392779) which is seen in Q9CIN1_LACLA.Residues 76-144 are 59% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD387947) which is seen in Q9CIN1_LACLA.Residues 311-510 are 22% similar to a (C24F3.5) protein domain (PD218211) which is seen in Q21213_CAEEL.Residues 190-230 are 46% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in Q9CIN1_LACLA.Residues 318-503 are 25% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in O27709_METTH.Residues 370-486 are 31% similar to a (REPEAT CG8473 D) protein domain (PD318904) which is seen in Q9VXP7_DROME.Residues 311-358 are 50% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CIN1_LACLA.Residues 428-470 are 69% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CIN1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:35:50 2002","Wed Oct 23 15:29:14 2002","Tue Oct 15 13:44:04 2002","Fri Mar 8 16:57:56 2002","Sun Jan 13 13:39:46 2002","Sun Jan 13 13:39:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1757 is paralogously related (blast p-value < 1e-3) to SMu1950, SMu0884, SMu1949, SMu1288, SMu0218, SMu0786, SMu0517, SMu0731, SMu1762, SMu1380, SMu1023, SMu0823, SMu0418, SMu0971, SMu1210, SMu0916, SMu1003, SMu1316, SMu1246, SMu1231, SMu0849, SMu0805, SMu0258, SMu1065, SMu1920, SMu1064, SMu1710, SMu1428, SMu0335, SMu1410, SMu0824, SMu1036, SMu1068, SMu0907, SMu1079, SMu1811, SMu0976, SMu0836, SMu1751, SMu0374, SMu1959, SMu0234, SMu1037, SMu0476, SMu0164, SMu0825, SMu0594, SMu0986, SMu0390, SMu0944, SMu1001, SMu0950, SMu0235, SMu0216, SMu0475, SMu0752, SMu1517, SMu0837, SMu1518, SMu1306, SMu1724, SMu1545, SMu0729, SMu0224, SMu0596, SMu1649, SMu1093, SMu0024, SMu0987, SMu0666, SMu1050, SMu1686, and SMu1202, all ABC transporter, ATP-binding proteins.","Fri Mar 8 16:57:56 2002","Sun Jan 13 13:39:46 2002","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 96 8e-021pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 92 2e-019","SMU.1934c","","Residues 32 to 222 (E-value = 2.7e-39) place SMu1757 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 321 to 503 (E-value = 2.5e-49) place SMu1757 in the ABC_tran family which is described as ABC transporter (PF00005)","Sun Jan 13 13:39:46 2002","24380283","","","","Tue Oct 29 14:35:50 2002","","1","","","SMU.1934c","167" "SMu1758","1814751","1814206","546","ATGAAAAATAATTCAATTAAAGCAGTTGTCGCAACAGGGATTGGAGCAGCCTTATTTGTTATTATTGGTATGTTTATCAATATTCCACTCTTTGCTAATACAAGTATTCAGCTGCAATATGCTGTTCAAGCCTTTTTAGCTGTTATTTTTGGTCCAGTTGTCGGCTTCTTTATTGGTTTAATCGGTCATATGGTAAAAGATATGTTTGCTGGTTATGGTATTTGGTGGTCATGGGTTATTCCAAGCGGCCTTGTTGGTCTTGGAATTGGTTTTTTGAGAAATCGTCTTCATGTTGAAAAGGGAATCTTTTCAACTAAAGATGTTGTTACCTTTAATATTGTTCAAGTGCTGGTAAACGTTCTTGCTTGGGGAGTTATCGCACCTCTTGGCGATATCATTATTTTTAAAGAGCCAGCAAGCAAGGTTTTTGTTCAAGGTTTGTTAGCTAGTGTTGCCAATGCTCTAACAGTTGGTGTTGGCGCTACCATTCTTTTGGCTATTTATGCAAAAAGTCGGACACAAGCAGGAAGTTTATCAAAAGATTAA","10.70","6.46","19220","MKNNSIKAVVATGIGAALFVIIGMFINIPLFANTSIQLQYAVQAFLAVIFGPVVGFFIGLIGHMVKDMFAGYGIWWSWVIPSGLVGLGIGFLRNRLHVEKGIFSTKDVVTFNIVQVLVNVLAWGVIAPLGDIIIFKEPASKVFVQGLLASVANALTVGVGATILLAIYAKSRTQAGSLSKD","1814222","For other components see SMu1757 (NBD1 and NBD2) and SMu1756 (MSD1).Smu1758 was previously sequenced and submitted to GenBank as unknown (gi:15625435) by Tao,L. and Tanzer,J.M.","conserved hypothetical protein ","Membrane, Cytoplasm","This is a potential ABC transporter membrane spanning permease. Several moderate hits in gapped BLAST to conserved hypothetical proteins; residues 1-181 are 57% similar to hypothetical protein of Lactococcus lactis (gi6165407).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1634 (3e-58).","

InterPro
IPR009825
Family

Protein of unknown function DUF1393
PF07155	$\"[3-181]T$	DUF1393

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-181 are 57% similar to a (PROTEOME COMPLETE YDCD) protein domain (PD307394) which is seen in Q9CIN2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 16:41:17 2002","Fri Mar 16 14:21:12 2007","Fri Mar 16 14:20:11 2007","Fri Mar 8 16:48:42 2002","","Fri Mar 8 16:48:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1758 is paralogously related (blast p-value < 1e-3) to SMu0078, conserved hypothetical protein.","Fri Apr 26 09:23:18 2002","","No significant hits to the NCBI PDB database.","SMU.1935c","","Residues 3 to 181 (E-value = 1.2e-134) place SMu1758 in the DUF1393 family which is described as Protein of unknown function (DUF1393) (PF07155)","Fri Mar 8 16:48:42 2002","24380284","","","","Mon Oct 28 16:41:17 2002","","1","","","SMU.1935c","845" "SMu1759","1815606","1814761","846","ATGAGTAATAATTTATTAGTCTTGCAGTCAGATTTTGGCTTGGTTGATGGTGCTGTATCTGCGATGATTGGTGTCGCTTTGCAAGAAGCCCCAACACTCGGTATTCACAATTTAACTCATGAAATAACTCCTTACAACATTTTTGAAGCTTCTTATCGTCTCTTTCAGACAGTTGAATATTGGCCTCAAGGAACTACCTTTGTCTCAGTGGTTGATCCGGGAGTTGGCTCAGACAGGAAAAGCGTTGTGGCCTTAACGTCAAGAAATCAGTATATTGTGACGCCTGATAATGGGACTTTATCTTATATCAAGAAGCATGTTGGTATCAAAGCTGTTCGTGAGATTTCAGAAATTGAGAATCGTCGTCGTAATACAGAATTATCCTACACTTTTCATGGACGTGATGTCTATGCCTTTACAGGAGCCAAATTGGCTAGTGATCATATTTCTTTTGAAGAAGTTGGTCCAGAATTAGCTATTGAGTCTATAGTAGAATTACCAGTGGTTGAAACCGTTATTGAAGATAATCTTGTTCGTGGTGCCGTTGATATTCTGGATGTTCGTTTTGGTTCTTTATGGACGTCTATTACACGTGAAGAATTTTACACGCTTAAGCCAGAATTCAATGATCGCTTTGAAGTAACTATCTACAATAATGATATGCTCGTTTATCAAAATCAAGTGACCTATGGCAAATCATTTGCAGCTGTTCGGATTGGTCAACCCATTATTTATATCAATTCTCTCTATCGTGTGGGCGTTGCTATTAACCAAGGTTCTTTTGCTAATGCCTACAATGTCGGTGTCGGACCTCAGTGGCGTATCGAAATCAAAAAATTAAATTAA","5.10","-6.78","31482","MSNNLLVLQSDFGLVDGAVSAMIGVALQEAPTLGIHNLTHEITPYNIFEASYRLFQTVEYWPQGTTFVSVVDPGVGSDRKSVVALTSRNQYIVTPDNGTLSYIKKHVGIKAVREISEIENRRRNTELSYTFHGRDVYAFTGAKLASDHISFEEVGPELAIESIVELPVVETVIEDNLVRGAVDILDVRFGSLWTSITREEFYTLKPEFNDRFEVTIYNNDMLVYQNQVTYGKSFAAVRIGQPIIYINSLYRVGVAINQGSFANAYNVGVGPQWRIEIKKLN","1814777","Smu1759 was previously sequenced and submitted to GenBank as unknown (gi:15625434) by Tao,L. and Tanzer,J.M.","conserved hypothetical protein","Cytoplasm","Several moderate hits to conserved hypothetical proteins; residues 1-280 are 79% similar to conserved hypothetical protein of Streptococcus pneumoniae (gi|14971953).SMu1759 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002747
Family

Protein of unknown function DUF62
PD013834	$\"[22-272]T$	DUF62
PIRSF006779	$\"[4-278]T$	UCP006779
PF01887	$\"[5-277]T$	DUF62

noIPR
unintegrated

unintegrated
SSF101852	$\"[169-277]T$	SSF101852
SSF102522	$\"[3-168]T$	SSF102522

","BeTs to 6 clades of COG1912COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1912 is am-k-qv-----uj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 22-270 are 46% similar to a (PROTEOME COMPLETE APE2338 MJ1651) protein domain (PD013834) which is seen in O25413_HELPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:58:31 2002","Fri Mar 8 16:35:54 2002","Tue Oct 8 14:58:31 2002","Fri Mar 8 16:35:54 2002","","Fri Mar 8 16:35:54 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1759 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:58:31 2002","","No significant hits to the NCBI PDB database.","SMU.1936c","","Residues 5 to 277 (E-value = 9.7e-78) place SMu1759 in the DUF62 family which is described as Protein of unknown function DUF62 (PF01887)","Fri Mar 8 16:35:54 2002","24380285","","","","Tue Oct 8 14:58:31 2002","","1","","","SMU.1936c","" "SMu1760","1816506","1815730","777","TTGAAAATTAGTCTTTTGCAATTAGATATAAAAGATGGTCAGTCTCATGTTAATCAGGCAAACGTCCAAAATCTTTTACAAGAAGCACTCTTAGAAGAGCCGGATGTCATTGTTTTACCAGAATTATGGAACAGTGGTTATGCGTTGGATAAATTAGAAAAAATTGCTGATGAAGATGGGAAAGTCAGCCGTCCTTGGCTTAGTCAATTTGCTGAGAAACATGGAGTTACTTTAGTTGCTGGATCTGTAGCGACTAAACGAAAAGGCCAATTTTACAATACAGCTTACAGTTTTTCTTCGAAAGGACAGCTGATAAATACTTATGATAAGGTCCATCTTTTTGGTCTAATGGCTGAAGATAAATTTTTGACTGCTGGACAAAGAGAAAGTCATTTTCAAATTGGAACTGTTGGTGCCAGCCATGTTATTTGTTACGATATCCGCTTTCCTGAATGGATTCGTCATTTGATGAGTCAAGATGCTGCTCTTTTATTTGTTTCAGCCCAGTGGCCCAGCAGCCGCATTGAACAATGGAGGATCCTTTTACAAGCGCGTGCTATTGAAAATCAGGCCTTTGTCATTGCTGTTAATCGTGTCGGACAGGGGCTCAAGGACCAGTTCAACGGTCATTCTTTAATCATTGATCCTTTGGGAAAAATTCTTTTAGAGGCAAATGATTGTGAAGGAGTTTTTAGTGCTCAGATAGATCTAAACCAAGTTAAAAAGGTTCGTGGTCAGATTCCTGTTTTTAAAGATAGACGTTTGGAACTTTATTAA","6.90","-0.40","29101","MKISLLQLDIKDGQSHVNQANVQNLLQEALLEEPDVIVLPELWNSGYALDKLEKIADEDGKVSRPWLSQFAEKHGVTLVAGSVATKRKGQFYNTAYSFSSKGQLINTYDKVHLFGLMAEDKFLTAGQRESHFQIGTVGASHVICYDIRFPEWIRHLMSQDAALLFVSAQWPSSRIEQWRILLQARAIENQAFVIAVNRVGQGLKDQFNGHSLIIDPLGKILLEANDCEGVFSAQIDLNQVKKVRGQIPVFKDRRLELY","1815746","","hydrolase, carbon-nitrogen family","Cytoplasm","Smu1760 was previously sequenced and submitted to GenBank as putative carbon-nitrogen hydrolase (gi:15625433) by Tao,L. and Tanzer,J.M.Many moderate hits in gapped BLAST to conserved hypothetical proteins and possible hydrolases; residues 1-257 are 34% similar to probable hydrolase of Streptomyces coelicolor (gi7480759), residues 1-258 are 32% similar to Predicted amidohydrolase of Clostridium acetobutylicum (gi15894942).SMu1760 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003010
Domain

Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase
G3DSA:3.60.110.10	$\"[1-258]T$	no description
PF00795	$\"[2-169]T$	CN_hydrolase
PS50263	$\"[1-258]T$	CN_HYDROLASE

noIPR
unintegrated

unintegrated
PIRSF001253	$\"[1-258]T$	Nitrilase (carbon-nitrogen hydrolase)
PTHR23088	$\"[83-258]T$	NITRILASE-RELATED

","BeTs to 11 clades of COG0388COG name: Predicted amidohydrolaseFunctional Class: RThe phylogenetic pattern of COG0388 is A-tkYQVCEBR-UJ-------Number of proteins in this genome belonging to this COG is 1","***** IPB001110 (Uncharacterized protein family UPF0012) with a combined E-value of 9.6e-26. IPB001110B 108-116 IPB001110C 138-159 IPB001110D 177-193 IPB001110E 209-218***** IPB000132 (Nitrilase / cyanide hydratase) with a combined E-value of 1.2e-06. IPB000132A 14-48 IPB000132B 50-96 IPB000132D 209-218 IPB000132E 228-257","Residues 67-144 are 44% similar to a (PROTEOME COMPLETE HYDROLASE NITRILASE) protein domain (PD346093) which is seen in O31664_BACSU.Residues 3-66 are 40% similar to a (PROTEOME COMPLETE YKRU) protein domain (PD387440) which is seen in O31664_BACSU.Residues 1-57 are 37% similar to a (PROTEOME COMPLETE ORF AGR) protein domain (PD240233) which is seen in Q9KE11_BACHD.Residues 78-237 are 40% similar to a (HYDROLASE NITRILASE COMPLETE PROTEOME) protein domain (PD052217) which is seen in O30121_ARCFU.Residues 145-213 are 46% similar to a (PROTEOME COMPLETE NITRILASE HYDROLASE) protein domain (PD000957) which is seen in Q9KE11_BACHD.Residues 145-258 are 34% similar to a (HYDROLASE PROTEOME COMPLETE BETA-ALANINE) protein domain (PD356362) which is seen in Q9ZQH4_ARATH.Residues 1-144 are 25% similar to a (PROTEOME PA3797 COMPLETE ASPV-FADF) protein domain (PD415485) which is seen in Q9HXK0_PSEAE.Residues 37-216 are 28% similar to a (PROTEOME COMPLETE TA0888) protein domain (PD258179) which is seen in Q9HJS6_THEAC.Residues 1-129 are 29% similar to a (PROTEOME COMPLETE HYDROLASE NMA2044) protein domain (PD357575) which is seen in Q9XA70_STRCO.Residues 1-126 are 39% similar to a (DOMAIN OF UNKNO N) protein domain (PD398229) which is seen in O68163_STAEP.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu May 2 12:58:27 2002","Thu Mar 1 13:41:44 2007","Thu Mar 1 13:41:44 2007","Fri Mar 8 16:31:12 2002","Fri Mar 8 16:31:12 2002","Fri Mar 8 16:31:12 2002","yes","Mon Oct 21 10:51:04 2002","SMu1760 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu May 2 12:58:27 2002","Thu Mar 1 13:41:44 2007","pdb1EMSA Chain A, Crystal Structure Of The C. Elegans Nitfhit... 102 5e-023pdb1EMSA Chain A, Crystal Structure Of The C. Elegans Nitfhit... 380 1e-106","SMU.1937c","","Residues 2 to 169 (E-value = 4.2e-20) place SMu1760 in the CN_hydrolase family which is described as Carbon-nitrogen hydrolase (PF00795)","Fri Mar 8 16:31:12 2002","","","","","Thu Mar 1 13:41:44 2007","","1","","","SMU.1937c","" "SMu1761","1817263","1816574","690","ATGCATTTTATTCAAACCTATTTACCCAATGCTTATGAGCTTGGTTTGACAGGAGATGCTGGTTGGTTAACAGCAATTCTGAATACACTTTATATGACTATTGTTCCTTTTGTTATTGGAGGAGGCGTTGGTCTGGTTTTTGGTCTTCTCTTAGTATTGATGGGACCTGAAGGTGTTATTGAAAATAAGGTTGTTTGTTGGATCATTGATAAAGTAACATCTGTTTTCCGCGCCATTCCTTTTGTTATTTTGATTGCTGTCTTAGCACCATTAACCATGCTTTTGATGCAAACGAATTTAGGTGCGACAGCAGCCTTGGTTCCTTTATCTTTTGCGACTTTTCCTTTCTTTGCACGGCAAGTACAGGTTGTCTTTTCTGAATTGGATCGCGGTGTTATTGAGGCAGCACAAGCTTCTGGAGCTACCTTTTGGGATATTGTAAAGGTCTATCTCAGTGAAGGTTTTCCGGATCTTATTCGTGTCTCAACAGTAACCTTGATTTCTCTTGTTGGTGAAACGGCTATGGCCGGAGCAATCGGAGCTGGGGGACTTGGGAATGTTGCTATTTCTTACGGCTATAATCGTTTTAATAATGATGTCACTTGGGTTGCAACTTTACTTATTCTTTTGCTTATTTTTACAATCCAATTTATTGGAGATACGCTAACTCGAAAAGTAAGTCATCGTTAA","5.20","-2.58","24675","MHFIQTYLPNAYELGLTGDAGWLTAILNTLYMTIVPFVIGGGVGLVFGLLLVLMGPEGVIENKVVCWIIDKVTSVFRAIPFVILIAVLAPLTMLLMQTNLGATAALVPLSFATFPFFARQVQVVFSELDRGVIEAAQASGATFWDIVKVYLSEGFPDLIRVSTVTLISLVGETAMAGAIGAGGLGNVAISYGYNRFNNDVTWVATLLILLLIFTIQFIGDTLTRKVSHR","1816590","For other components see SMu1762 (NBD1) ; SMu1765 (SBP1) and SMu1764 (SBP2).For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762(atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1210 (atmB); SMu1764 (atmB) and SMu1763 (atmC). ","amino acid ABC transport permease","Membrane, Cytoplasm","Smu1761 is similar to a protein previously sequenced and submitted to GenBank as AtmE (gi:15625432) by Tao,L. and Tanzer,J.M. Several strong hits in gapped BLAST to ABC transporter, permease protein; residues 18-229 are 64% similar to a possible ABC transporter (permease protein) of Streptococcus pyogenes (gi15674485), residues 4-229 are 55% similar to ABC transporter membrane-spanning permease - unknown substrate of Streptococcus pneumoniae (gi15902194).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1638 (1e-58).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[26-228]T$	BPD_transp_1
PS50928	$\"[26-219]T$	ABC_TM1

","BeTs to 5 clades of COG2011COG name: Permease component of an uncharacterized ABC transporterFunctional Class: RThe phylogenetic pattern of COG2011 is --------eb-huj---l-n-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 115-165 are 51% similar to a (TRANSPORT PERMEASE COMPLETE PROTEOME TRANSMEMBRANE) protein domain (PD349044) which is seen in Q9PF04_XYLFA.Residues 115-165 are 59% similar to a (PROTEOME AMINO COMPLETE TRASPORTER) protein domain (PD411500) which is seen in Q9CIN3_LACLA.Residues 29-110 are 40% similar to a (COMPLETE PROTEOME PERMEASE ABC) protein domain (PD030333) which is seen in Q9CIN3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 16:24:11 2006","Thu Aug 31 16:24:11 2006","Thu Aug 31 16:24:11 2006","Fri Mar 8 15:39:05 2002","","Fri Mar 8 15:39:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1761 is paralogously related (blast p-value < 1e-3) to SMu1002, a predicted phosphate ABC transporter; SMu0219,a predicted amino acid ABC transporter, permease (potential glutamine permease) and SMu1921, a predicted glycine betaine/carnitine/choline ABC transporter permease (membrane p).","Mon Apr 15 16:37:58 2002","","No significant hits to the NCBI PDB database.","SMU.1938c","","Residues 26 to 228 (E-value = 8.8e-10) place SMu1761 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Fri Mar 8 15:39:05 2002","24380287","","","","Mon Oct 28 08:26:45 2002","","1","","","SMU.1938c","599" "SMu1762","1818329","1817265","1065","ATGAGTAAAGCGATTATAAAACTTGACCATATTGATATCACTTTTCACCAAAAGAAGCGAACTATTGAAGCGGTTAAAGGTGTCACAGTACATATTAATCAAGGTGATATTTATGGTATTGTTGGTTATTCTGGCGCCGGTAAGTCCACTCTTGTTCGTGTGATTAATCTTTTGCAGACCCCAACAAAAGGAAAAATTACAGTAGATCAAGATGTGATTTTTGAAAATGGTGAAAAGCGGTTATCCAGTCAGGAACTCAGAAAGAAGCGTCATGAAATTGGTATGATTTTTCAGCATTTTAATTTAATGGCTCAGAAGACTGCGCGCCAAAATGTTGCTTTTGCCTTGCGTCATTCCAATCTTAGTGCAGCGCAAAAAGAAAGCAAAGTAACAGAATTATTAGAATTGGTGGGCTTAACTGATCGTGCAGAGAATTACCCTTCACAGCTTTCTGGCGGTCAAAAACAACGTGTCGCGATTGCTCGAGCTCTTGCTAATGATCCTAAAATTCTGATTTCAGATGAAGCTACTTCGGCCTTAGATCCCAAAACAACCAAGCAAATTTTAGCACTTTTACAAGATTTAAATAAAAAATTGGGATTGACTGTTGTCATGATTACTCATGAGATGCAAATTGTTAAAGATATTTGCAATCGTGTGGCTGTCATGCAGGAAGGTTCTCTAATTGAAGAAGGATCTGTTTTAGATATTTTTTCAAATCCTAGAGAAGACTTAACCAAAGACTTCATCAAAACAGCAACGGGAATTGAAGAAGCTTTGATAAAGATTAAACAGCAAGAAATCGTTAAAAACTTGCCAGCTAATGCTGCTTTGGTGCAATTAAAATACGCGGGTAAAACCACGGATGAGCCTATTTTAAATAACCTTTATAAAAAATATCAAGTCACTGCTAATATTCTGTATGGCAATATAGAAATTTTAGAAAAGACACCTGTTGGTGAGATGATTGTTATTTTAGAGGGCGCAGCTACTAATATTGATCAAGCACTTAATGATTTAACACATTCAGATTTAACAGTAACGGTTTTAAAGAGAGGAGTTTAA","9.60","5.90","39154","MSKAIIKLDHIDITFHQKKRTIEAVKGVTVHINQGDIYGIVGYSGAGKSTLVRVINLLQTPTKGKITVDQDVIFENGEKRLSSQELRKKRHEIGMIFQHFNLMAQKTARQNVAFALRHSNLSAAQKESKVTELLELVGLTDRAENYPSQLSGGQKQRVAIARALANDPKILISDEATSALDPKTTKQILALLQDLNKKLGLTVVMITHEMQIVKDICNRVAVMQEGSLIEEGSVLDIFSNPREDLTKDFIKTATGIEEALIKIKQQEIVKNLPANAALVQLKYAGKTTDEPILNNLYKKYQVTANILYGNIEILEKTPVGEMIVILEGAATNIDQALNDLTHSDLTVTVLKRGV","1817281","For other components see SMu1761 (MSD1) ; SMu1765 (SBP1) and SMu1764 (SBP2).For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu0971 (atmD); SMu1002 (atmE); SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA) ; SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).","amino acid ABC transport ATP-binding protein","Cytoplasm, Membrane","This sequence corresponds to the previously sequenced gi|15625431 and gi|4098078 in GenBank, a predicted AtmD protein. See also gi|15625442, gi|9802355, gi|153741, gi|282320, g547928.Many hits in gapped BLAST to ABC transporter ATP-binding proteins; residues 1-351 are 73% similar to ABC transporter, ATP-binding protein of Streptococcus pneumoniae (gi|15900089), residues 4-330 are 52% similar to amino acid ABC transporter ATP binding protein of Lactococcus lactis (gi|15672304).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1639 (1e-147).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[149-192]T$	ABC_transporter
PF00005	$\"[35-226]T$	ABC_tran
PS00211	$\"[150-164]T$	ABC_TRANSPORTER_1
PS50893	$\"[8-250]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[34-249]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[5-259]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-316]T$	PTHR19222
PTHR19222:SF34	$\"[6-316]T$	PTHR19222:SF34
SSF52540	$\"[5-274]T$	SSF52540

","BeTs to 6 clades of COG1135COG name: Uncharacterized ABC-type transport system ATPase component/cell division protein FtsEFunctional Class: D,RThe phylogenetic pattern of COG1135 is -------cEBrHuj---l-n-Number of proteins in this genome belonging to this COG is 2","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 6.3e-38. IPB001140A 24-70 IPB001140B 147-185 IPB001140C 203-232","Residues 278-351 are 32% similar to a (ATP-BINDING ABC PROTEOME COMPLETE) protein domain (PD403055) which is seen in Q9ZJ34_HELPJ.Residues 195-250 are 44% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER) protein domain (PD019551) which is seen in O26096_HELPY.Residues 134-226 are 34% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 201-242 are 54% similar to a (ATP-BINDING TRANSPORT ABC COMPLETE) protein domain (PD284383) which is seen in O83157_TREPA.Residues 83-147 are 41% similar to a (ATP-BINDING TRANSPORT PROTEOME SYSTEM) protein domain (PD239735) which is seen in Q9PPE5_CAMJE.Residues 195-232 are 55% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9PF03_XYLFA.Residues 111-247 are 24% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q44375_AGRTU.Residues 132-214 are 37% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD033004) which is seen in Q9V0X7_PYRAB.Residues 194-232 are 61% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in O32169_BACSU.Residues 130-208 are 44% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in Q9CCF9_MYCLE.Residues 90-147 are 43% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in O32169_BACSU.Residues 16-228 are 28% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 278-330 are 37% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD015783) which is seen in Q9CIN4_LACLA.Residues 150-188 are 61% similar to a (RESISTANCE ATP-BINDING MULTIGENE) protein domain (PD250459) which is seen in MDR1_LEIEN.Residues 25-79 are 65% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CIN4_LACLA.Residues 149-192 are 90% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CIN4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 13:39:41 2002","Fri Mar 8 16:16:03 2002","Tue Oct 15 13:39:41 2002","Fri Mar 8 16:16:03 2002","Sun Jan 13 13:58:11 2002","Sun Jan 13 13:58:11 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1762 is paralogously related (blast p-value < 1e-3) to SMu0517, SMu0731, SMu0218, SMu0786, SMu0849, SMu0418, SMu1380, SMu0971, SMu1210, SMu1246, SMu1231, SMu0235, SMu1068, SMu1950, SMu1003, SMu1288, SMu1920, SMu0884, SMu1751, SMu1949, SMu0234, SMu1036, SMu1079, SMu0594, SMu1518, SMu0916, SMu0805, SMu1001, SMu1428, SMu0335, SMu1757, SMu1037, SMu0390, SMu1649, SMu0944, SMu1023, SMu0374, SMu0950, SMu0976, SMu0907, SMu0836, SMu0825, SMu0596, SMu0987, SMu0986, SMu0752, SMu1517, SMu1710, SMu1316, SMu0476, SMu1410, SMu0258, SMu1064, SMu0824, SMu0164, SMu0216, SMu0837, SMu1959, SMu1811, SMu1545, SMu1050, SMu1724, SMu0475, SMu0823, SMu1065, SMu0666, SMu0224, SMu0024, SMu1093, SMu1306, and SMu0729, all ABC tranporter, ATP-binding proteins.","Fri Mar 8 16:16:03 2002","Sun Jan 13 13:58:11 2002","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 165 6e-042pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 136 5e-033","SMU.1939c","","Residues 35 to 226 (E-value = 2.2e-63) place SMu1762 in the ABC_tran family which is described as ABC transporter (PF00005)","Sun Jan 13 13:58:11 2002","24380288","","Russell,R.R., Aduse-Opoku,J., Sutcliffe,I.C., Tao,L. andFerretti,J.J.A binding protein-dependent transport system in Streptococcusmutans responsible for multiple sugar metabolismJ. Biol. Chem. 267 (7), 4631-4637 (1992) PubMed: 1537846.","","Fri Mar 8 16:16:03 2002","","1","","","SMU.1939c","451" "SMu1763","1819695","1818322","1374","ATGGCATTTTCAAGTGAACAAGAGCAAATTGCTAAATTTTGGCAGGATGAAGTTGCTCAGCATTATTTTGAGGTTTTACGGACCTTAATTTCCAAAAAATCTATTTTTGCACAACAGATAGGCCTGCAGGATGTTGCAGGCTATTTGGGCGAAATTTTTGCCAATGTCGGTGCTGAAGTGACAATTGATGAAACCTATACGGCTCCTTTTGTTATTGCTAAATTTAAAAGTTCCAAACCTCAGGCTAAAACCATTATTTTTTATAACCATTATGATACAGTACCTGCAGATAATGATCAGATTTGGACAGATAATCCCTTTAAACTGACCTTAAGAAAAGGTTATATGTATGGCCGTGGTGTTGATGATGACAAAGGGCATATTACAGCTCGTTTGACAGCTGTTCGAAAGTATATTCGTGAGGTTGGGGACCTTCCTGTTAATGTTACTTTTATAATAGAAGGAGCTGAAGAATCTGCTTCAACAGATCTTGACAAGTATTTAAAAAAATATGCGGATAGTTTGCTTCCTGCAGATGTTTTGATTTGGGAACAAGGTGTTAAAAATAGTCAGGGTCAGTTAGAAATTACAGGTGGTAATAAAGGTATTATTACTTTTAATCTTTCTGTATCCAGTGCAGAGGTTGATATTCACTCAAAATATGGTGCGGTTATTGAATCGGCAGCATGGTATCTCTTAAATGCAATTTCCAGTATGCGAGCAGATGATGGTCAGATTTTGATCGATGGTATTTATGATCAGGTCTTGGAGCCCAATGAGCGTGAATTGGATTTAGTAGAGCGTTATGCTCTTGAAAATAGTGAAGGTTTGCGCAAAGTTTATGGTTTAAAATTACCAACTTTAAAAAAAGAGCGTCGTGATTTTCTTAAAACCTATTTTTTTGAACCCGCCTTATCCATAGAAGGACTTTCTTCTGGTTATCAAGGGCAAGGTGTGAAAACAATTCTGCCTTCTGCTGCCAGTGCTAAGATGGAAATGCGTTTAGTTCCCGGTCTCAGTCCCCAGTACGTTTTTGAAAAGATTAATAGTCATTTGAGAAAATTAGGCTTTGAACATGTTAAGGTAACCTATACCTTAGGCGAAGAATCTTATCGCAGTGATATGAGTGCTCCGGCTATTTTGACCATTATTGACTTGGCTAAGCAATTTTATGAAGCTGGCGTATCTGTTCTGCCCACTGCTGCTGGTACAGGTCCTATGCATACGGTTTATGATGCTTTGGGCATTCCTATGTTAGCTTTTGGACTTGGCAATCCCAATAGTCGCGATCACGGTGGTGATGAAAATGTTAATTTAGCAGACTATTATACCCATATTGAATTAATTAAGGAGTTAATTAGAAGTTATGAGTAA","5.00","-13.79","50986","MAFSSEQEQIAKFWQDEVAQHYFEVLRTLISKKSIFAQQIGLQDVAGYLGEIFANVGAEVTIDETYTAPFVIAKFKSSKPQAKTIIFYNHYDTVPADNDQIWTDNPFKLTLRKGYMYGRGVDDDKGHITARLTAVRKYIREVGDLPVNVTFIIEGAEESASTDLDKYLKKYADSLLPADVLIWEQGVKNSQGQLEITGGNKGIITFNLSVSSAEVDIHSKYGAVIESAAWYLLNAISSMRADDGQILIDGIYDQVLEPNERELDLVERYALENSEGLRKVYGLKLPTLKKERRDFLKTYFFEPALSIEGLSSGYQGQGVKTILPSAASAKMEMRLVPGLSPQYVFEKINSHLRKLGFEHVKVTYTLGEESYRSDMSAPAILTIIDLAKQFYEAGVSVLPTAAGTGPMHTVYDALGIPMLAFGLGNPNSRDHGGDENVNLADYYTHIELIKELIRSYE","1818338","For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762(atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1210 (atmB); SMu1764 (atmB) and SMu1761 (atmE).For other 'dap' genes see SMu0821 (dapB) and SMu0900 (dapA). ","peptidase, possible succinyl-diaminopimelic descuccinlyase","Cytoplasm, Extracellular","Smu1763 was previously sequenced and submitted to GenBank as AtmC, putative peptidase (gi:15625430), by Tao,L. and Tanzer,J.M. Several strong hits in gapped BLAST to desuccinlyases/deacetylases/peptidases; residues 1-457 are 71% similar to Succinyl-diaminopimelic descuccinlyase (ArgE/DapE/Acy1 family protein) of Streptococcus pneumoniae (gi15902192), residues 24-456 are 34% similar to Deacetylase of Sulfolobus solfataricus (gi15899453).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1640 (1e-165).","

InterPro
IPR002933
Family

Peptidase M20
PF01546	$\"[86-455]T$	Peptidase_M20

InterPro
IPR011650
Domain

Peptidase M20, dimerisation
PF07687	$\"[198-360]T$	M20_dimer

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.10	$\"[15-456]T$	G3DSA:3.40.630.10
PTHR11014	$\"[17-248]T$ $\"[293-456]T$	PTHR11014
PTHR11014:SF15	$\"[17-248]T$ $\"[293-456]T$	PTHR11014:SF15
SSF53187	$\"[17-456]T$	SSF53187
SSF55031	$\"[202-369]T$	SSF55031

","BeTs to 12 clades of COG0624COG name: Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylasesFunctional Class: EThe phylogenetic pattern of COG0624 is AM-KYqV-EBRHuj-----nxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 157-255 are 34% similar to a (PROTEOME COMPLETE FAMILY PEPTIDASE) protein domain (PD361106) which is seen in Q9RSV5_DEIRA.Residues 41-145 are 37% similar to a (COMPLETE PROTEOME HYDROLASE DESUCCINYLASE) protein domain (PD001449) which is seen in Q9RSV5_DEIRA.Residues 303-437 are 31% similar to a (PROTEOME COMPLETE FAMILY FIS) protein domain (PD024139) which is seen in Q9RSV5_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon May 23 10:05:05 2005","Mon May 23 10:05:05 2005","Mon May 23 10:03:16 2005","Fri Mar 8 15:22:04 2002","","Fri Mar 8 15:22:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1763 is paralogously related (blast p-value < 1e-3) to SMu1134, dipeptidase.","Fri Mar 8 15:24:23 2002","","No significant hits to the NCBI PDB database.","SMU.1940c","","Residues 26 to 456 (E-value = 5.6e-48) place SMu1763 in the Peptidase_M20 family which is described as Peptidase family M20/M25/M40 (PF01546)","Fri Mar 8 15:22:04 2002","24380289","","","","Mon May 23 10:03:16 2005","","1","","","SMU.1940c","846" "SMu1764","1820732","1819890","843","ATGAAACTTAAAAAAATATTAGGTCTTTTAGGATTGGCTTTAGCTGCGGCATTTGTTTTAACGGCTTGCGGTCAAAAAAATGATAAAAATACGTTAACTGTTGGTGTGATGACCATGACTGATTCTGATAAAGAACGTTGGGATAAAATTGAGGAACTGCTTAAAAAAGAAAATATCAAACTTAAATTTAAAGAGTTTACAGATTATTCACAGCCGAATAAAGCTTTAAAAAACGGTGAAATTGACATCAATTCTTTCCAGCATTATAATTTCTTGAATAATTGGAACAAGGAAAACAAGGGTGATTTAGTTACTGTAGCTGAGACATATATCAGTCCGATTAATCTTTTCTCAGGCACAGAAAATGGTAAAGCAAAATACAGTAGTGCTAAGGAAATTCCAAATGGTGGTCAAATTGCTATTCCTAATGATGCTACTAACGAAAGCCGCGCTCTTTACGTTCTTCAAGATGCTGGCTTAATTAAATTAAATGTTTCTGGTGATGAATTGGCTACCGTTAAAAATATTAAGTCAAATCCCAAAAATCTTGATATTAAAGAAGTAGATGCTAGTCAAACAGCTCGTAATTTAGCATCCGTTGATGCTGCTGTTGTTAATAACAGTTACGCTGTTCCAGCAAAAATTGATTTCAAAACTTCTCTTTATAAAGAAAAAGTGAACGAAGGCTCTAAACAATGGATTAATATCATTGCAGCTCAAAAGAATTGGAAAAAATCAAAGAAGGCAGCAGCGATTAAGAAATTGATTAAGGCTTATCATACAGATGCTGTTAAAAAAGTTATTAAAAAGACTGCCAAAGGCGTTGATGAACCTGTTTGGTAA","10.30","13.44","31005","MKLKKILGLLGLALAAAFVLTACGQKNDKNTLTVGVMTMTDSDKERWDKIEELLKKENIKLKFKEFTDYSQPNKALKNGEIDINSFQHYNFLNNWNKENKGDLVTVAETYISPINLFSGTENGKAKYSSAKEIPNGGQIAIPNDATNESRALYVLQDAGLIKLNVSGDELATVKNIKSNPKNLDIKEVDASQTARNLASVDAAVVNNSYAVPAKIDFKTSLYKEKVNEGSKQWINIIAAQKNWKKSKKAAAIKKLIKAYHTDAVKKVIKKTAKGVDEPVW","1819906","For other components see SMu1762 (NBD1) ; SMu1761 (MSD1) and SMu1765 (SBP1). For other 'atm' genes see SMu0846 (atmA); SMu1765 (atmA);SMu1762(atmD);SMu0971 (atmD); SMu1002 (atmE);SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA); SMu1210 (atmB); SMu1763 (atmC) and SMu176 (atmE).","ABC transporter solute-binding protein","Membrane, Periplasm, Extracellular","Smu1764 was previously sequenced and submitted to GenBank as AtmB outer membrane lipoprotein (gi15625429) by Tao,L. and Tanzer,J.M. Several moderate hits in gapped BLAST to lipoproteins and to ABC transporter solute-binding proteins; residues 1-280 are 50% similar to lipoprotein of Streptococcus pneumoniae (gi15900087), residues 26-270 are 47% similar to outer membrane lipoprotein precursor of Lactococcus lactis (gi15672300).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0971 (8e-77).","

InterPro
IPR004872
Family

NLPA lipoprotein
PF03180	$\"[32-280]T$	Lipoprotein_9

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[31-179]T$	G3DSA:3.40.190.10
PS51257	$\"[1-23]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[31-280]T$	SSF53850

","BeTs to 5 clades of COG1464COG name: Lipoprotein, attached to the cytoplasmic membraneFunctional Class: MThe phylogenetic pattern of COG1464 is --------EB-huj---l-n-Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 67-270 are 54% similar to a (LIPOPROTEIN MEMBRANE OUTER PROTEOME) protein domain (PD006353) which is seen in Q9CIN7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 14:23:09 2007","Fri Mar 16 14:23:09 2007","Thu Sep 28 11:08:13 2006","Fri Mar 8 14:37:36 2002","","Fri Mar 8 14:37:36 2002","yes","Mon Oct 21 10:46:54 2002","SMu1764 is paralogously related (blast p-value < 1e-3) to SMu1765, and SMu0741, both amino acid ABC transporter, amino acid-binding protein.","Fri Mar 8 14:55:33 2002","","No significant hits to the NCBI PDB database.","SMU.1941c","","Residues 32 to 280 (E-value = 7.9e-111) place SMu1764 in the Lipoprotein_9 family which is described as NLPA lipoprotein (PF03180)","Fri Mar 8 14:37:36 2002","","","","","Mon Oct 28 13:38:47 2002","","1","","","SMU.1941c","555" "SMu1765","1821702","1820899","804","ATGAAATTGAAACATATTTTAAGAATTGGAGCGGTTGCTTTTGCCTCAATTCTTTTGTTAACTGCTTGCGGATCAAAAACATCTAAAAAAACAGTAACCCTTGCGACTGTTGGAACAACAAATCCATTTTCTTATGAGAAAAAGGGAAAATTGACGGGATATGATATCGAAGTTGCTAAGGAAGTTTTCAAAGCTTCTGATAAATACGATGTCAAATATCAAAAAACAGAGTGGACCAGCATTTTCTCTGGTCTAGATAGTGACAAATATCAAATCGGAGCTAACAATATCAGTTATACTAAAGAGCGTGCCAATAAATATCTTTATTCTAATCCAACGGCTTCCAATCCATTGGTATTAGTGGTTCCAAAAGATAGTGATATTAAGTCTTATAACGATATTGCTGGGCATAGCACTCAAGTTGTTCAAGGAAATACAACAGTGTCTATGCTGCAGAAATTCAATAAAAACCATGAAAACAATCAAGTTAAACTAAACTTTACCAGTGAAGATCTTGCGCATCAAATCCGGAATGTCAGTGATGGTAAGTATGATTTTAAAATTTTTGAAAAAATTTCAGCAGAAACGATCATCAAAGAGCAAGGACTTGATAATTTGAAAGTTATTGATCTTCCTTCAGACCAAAAACCATATGTTTACTTTATTTTTGCGCAAGACCAAAAAGACTTACAAAAGTTTGTCAATAAACGTCTCAAAAAACTTTACGAGAATGGTACACTTGAAAAATTATCGAAAAAATACCTTGGAGGAAGCTATCTTCCAGATAAAAAAGATATGAAATAA","10.20","12.91","30229","MKLKHILRIGAVAFASILLLTACGSKTSKKTVTLATVGTTNPFSYEKKGKLTGYDIEVAKEVFKASDKYDVKYQKTEWTSIFSGLDSDKYQIGANNISYTKERANKYLYSNPTASNPLVLVVPKDSDIKSYNDIAGHSTQVVQGNTTVSMLQKFNKNHENNQVKLNFTSEDLAHQIRNVSDGKYDFKIFEKISAETIIKEQGLDNLKVIDLPSDQKPYVYFIFAQDQKDLQKFVNKRLKKLYENGTLEKLSKKYLGGSYLPDKKDMK","1820915","For other components see SMu1762 (NBD1) ; SMu1761 (MSD1) and SMu1764 (SBP2).For other 'atm' genes see SMu0846 (atmA); SMu1762 (atmD);SMu0971 (atmD); SMu1002 (atmE); SMu1003 (atmD);SMu1036 (atmD);SMu1078 (atmA); SMu1112 (atmA) ; SMu1210 (atmD); SMu1764 (atmB); SMu1763 (atmC) and SMu176 (atmE).","amino acid ABC transporter substrate-binding protein","Periplasm, Membrane, Extracellular","This sequence corresponds to the previously sequenced gi15625428 in GenBank, a predicted AtmA (amino acid ABC transport substrate-binding) protein. Several hits in gapped BLAST to ABC transporter substrate-binding proteins; residues 3-267 are 52% similar to ABC transporter substrate-binding protein - amino acid transport of Streptococcus pneumoniae (gi15902190), residues 12-267 are 40% similar to amino acid ABC transporter substrate binding protein of Lactococcus lactis (gi15672919).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1642 (1e-88).","

InterPro
IPR001638
Family

Bacterial extracellular solute-binding protein, family 3
PF00497	$\"[32-257]T$	SBP_bac_3
SM00062	$\"[31-258]T$	PBPb

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[29-153]T$	G3DSA:3.40.190.10
PS51257	$\"[1-23]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[1-262]T$	SSF53850

","BeTs to 10 clades of COG0834COG name: Periplasmic amino acid binding proteinsFunctional Class: EThe phylogenetic pattern of COG0834 is A-----VCEBrHUJ---LINxNumber of proteins in this genome belonging to this COG is 8","***** IPB001638 (Bacterial extracellular solute-binding proteins, family 3) with a combined E-value of 3e-09. IPB001638A 49-58 IPB001638B 82-113","Residues 32-136 are 48% similar to a (COMPLETE PROTEOME PERIPLASMIC TRANSPORT ABC TRANSPORTER) protein domain (PD245531) which is seen in Q9CH05_LACLA.Residues 182-257 are 49% similar to a (AMINO TRANSPORTER ABC PERIPLASMIC) protein domain (PD090480) which is seen in Q9CH05_LACLA.Residues 127-267 are 35% similar to a (PROTEOME BINDING AMINO COMPLETE) protein domain (PD398808) which is seen in Q9CDZ9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 16:33:47 2006","Thu Aug 31 16:33:47 2006","Thu Aug 31 16:33:47 2006","Fri Mar 8 14:22:55 2002","Sun Jan 13 13:32:23 2002","Sun Jan 13 13:32:23 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1765 is paralogously related (blast p-value < 1e-3) to SMu0416, ABC transporter, periplasmic amino acid binding protein, SMu0846, amino acid ABC transporter, amino acid substrate-binding protein, SMu1078, amino acid ABC transporter, amino acid-binding protein, SMu1112, ABC transporter (binding protein), SMu0741, amino acid ABC transporter, amino acid-binding protein, SMu0732, amino acid ABC transporter, permease protein-glutamine transport, SMu0219, amino acid ABC transporter, permease (potential glutamine permease), SMu1764, and SMu1381.","Fri Mar 8 14:30:35 2002","","No significant hits to the NCBI PDB database.","SMU.1942c","","Residues 32 to 257 (E-value = 5.1e-59) place SMu1765 in the SBP_bac_3 family which is described as Bacterial extracellular solute-binding proteins, family 3 (PF00497)","Sun Jan 13 13:32:23 2002","24380291","","","","Thu Aug 31 16:33:47 2006","","1","","","SMU.1942c","600" "SMu1766","1824504","1822003","2502","ATGGTTTACTACAATCACAAAGCAATTGAGAATAAATGGCAAAAATTCTGGGAAGATAACCATACTTTTAAGACTGGAACGGCTTCCTCAAAACCAAAATTTTATGCCCTTGATATGTTTCCTTATCCATCTGGAGCTGGCCTACACGTTGGACACCCTGAGGGCTATACAGCGACAGATATTCTCAGTCGTTTCAAACGTGCGCAAGGCTACAATGTCCTTCACCCTATGGGCTGGGATGCTTTTGGTTTACCTGCTGAGCAATATGCTATGGACACGGGTCATGATCCTGCTGACTTTACAGCGCAAAATATTGCGACCTTTAAACGCCAAATTAAATCACTTGGTTTCTCTTATGATTGGGACCGTGAAATCAACACGACAGATCCTAACTACTATAAATGGACTCAGTGGATTTTTACCAAACTTTATGAAAAAGGTCTGGCTTATGAAGCTGAAGTGCCTGTCAACTGGGTTGAAGAACTAGGGACAGCTATTGCAAATGAAGAGGTGCTGCCAGACGGAACTTCTGAACGCGGTGGTTATCCTGTTGTCCGTAAACCTATGCGCCAATGGATGTTGAAAATCACAGCTTATGCTGAACGTCTCTTAGAAGATTTGGAAGATCTGGACTGGCCTGAGTCAATCAAAGATATGCAACGCAACTGGATTGGTAAATCAACTGGTGCCAATGTAACTTTCAAAGTCAAGGACACAGATGAGGAATTCACCGTTTTCACCACTCGTCCTGATACACTCTTTGGTGCTACTTATGCTGTTCTTGCTCCTGAGCATGATTTGGTAGATATTATTACTACTGCTGGCCAAGCGCAAGCAGTTGCTGATTATAAACATCAAGCCAGTCTCAAATCGGACTTAGCTCGTACAGACCTTGCCAAAGAAAAGACTGGTGTTTGGACGGGTGCCTATGCTATCAATCCTGTCAATGGCAAGGAGATTCCAATTTGGATAGCCGACTACGTGCTTGCTAGCTACGGAACAGGTGCTATCATGGCCGTTCCAGCTCATGACGAACGTGACTGGGAATTTGCTAAACAGTTTAATCTTGATATCATTCCCGTTCTTGAAGGTGGAAATGTAGCAGAAGCAGCTTATACAGATGACGGATTGCATATTAATTCTGGTTTCTTAAACGGCCTTGACAAGGCTGCCGCTATTGACAAGATGGTGACTTGGCTTGAAACTGAAGGTGTCGGTAATAAGAAAGTGACCTATCGCTTGCGTGACTGGCTCTTTAGCCGCCAACGATACTGGGGTGAGCCTATTCCAATTATTCATTGGGAAGATGGAACGAGTACAGCTCTTCCTGAAAATGAATTGCCACTTGTCTTACCAGTAACCAAGGACATCAAACCTTCAGGCACAGGTGAGTCTCCACTTGCCAACTTGACAGACTGGTTGGAAGTGACGCGTGAAGACGGTGTTAAAGGTCGCCGAGAAACCAACACTATGCCGCAGTGGGCAGGTTCTAGCTGGTATTTCCTACGCTATATTGATCCGCATAATGACCAAAAATTGGCCGATGAGGATCTTTTGAAACAATGGTTGCCAGTTGATGTTTATGTTGGCGGCGCTGAACATGCCGTTCTCCACTTGCTTTATGCACGTTTTTGGCATAAGTTTCTCTATGATCTTGGTGTTGTACCAACCAAAGAACCTTTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGAACCAGCTATCGCGATCATCGTGGTGCTTTAGTAGCAACAGATAAAGTTGAAAAACGTGATGGTTCTTTCTTCAACATCGAAACAGACGAAGAGTTGGAACAAGCACCGGCTAAGATGTCCAAATCACTCAAAAACGTTGTCAATCCTGACGATGTTGTCGAACAATATGGTGCTGATACCCTTCGTGTTTACGAAATGTTCATGGGGCCGCTTGATGCTTCCATTGCTTGGTCTGAAGAAGGTCTTGAAGGCAGCCGTAAATTTCTTGACCGTGTCTACCGTCTTATCACAACAAAAGAAATAGCTGCCAAAAACAATGGACACTTAGACAAGGTTTATAATGAAGTGGTTAAAACTGTAACAGAGCATCTTGAAGCTATGCGCTTTAACACAGCTATTTCTCAATTGATGATTTTTGTCAATGCCGCTAACAAGGAAGAACAACTCTTTCTTGATTATGCTAAGGGATTTATCCAGTTATTGGCACCATTTGCACCGCATTTAGCTGAAGAACTTTGGCAATTCTTAACGCAGTCTGGACAATCTATTACTTATGTTGCTTGGCCAAGTTATGATGAATCCAAATTGGTCGAAGACGAAATCGAGATTGTCCTTCAAATCAAAGGAAAAGTTCGTGCCAAGGTTGTTGTTTCTAAGGATTCCAGCCGTGAAGATCTTGAAAAAATTGCTCTTGCCAACGACAAAATCCAAGCAGAAGTTGCAGGAAAAGATATTGTAAAAGTTATTGCAGTGCCTAACAAACTGGTTAATATCGTGATTAAATGA","5.00","-28.31","94405","MVYYNHKAIENKWQKFWEDNHTFKTGTASSKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGYNVLHPMGWDAFGLPAEQYAMDTGHDPADFTAQNIATFKRQIKSLGFSYDWDREINTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEDLDWPESIKDMQRNWIGKSTGANVTFKVKDTDEEFTVFTTRPDTLFGATYAVLAPEHDLVDIITTAGQAQAVADYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPIWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVAEAAYTDDGLHINSGFLNGLDKAAAIDKMVTWLETEGVGNKKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALPENELPLVLPVTKDIKPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYFLRYIDPHNDQKLADEDLLKQWLPVDVYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGSFFNIETDEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEIAAKNNGHLDKVYNEVVKTVTEHLEAMRFNTAISQLMIFVNAANKEEQLFLDYAKGFIQLLAPFAPHLAEELWQFLTQSGQSITYVAWPSYDESKLVEDEIEIVLQIKGKVRAKVVVSKDSSREDLEKIALANDKIQAEVAGKDIVKVIAVPNKLVNIVIK","1822019","For other 'leu' genes see SMu1259 (leuD); SMu1260 (leuC); SMu1261 (leuB) and SMu1262 (leuA).","leucyl-tRNA synthetase","Cytoplasm, Cellwall","Numerous strong significant hits in gapped BLAST to leucyl-tRNA synthetase; residues 1-833 are 86% similar to leucyl-tRNA synthetase of Streptococcus pyogenes (gi15674378); residues 4-833 are 78% similar to leucyl-tRNA synthetase of Lactococcus lactis (gi15672798).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2057 (0.0).","

InterPro
IPR001412
Family

Aminoacyl-tRNA synthetase, class I
PS00178	$\"[43-53]T$	AA_TRNA_LIGASE_I

InterPro
IPR002302
Family

Leucyl-tRNA synthetase bacterial/mitochondrial, class Ia
PR00985	$\"[127-144]T$ $\"[153-169]T$ $\"[186-199]T$ $\"[215-234]T$ $\"[486-504]T$ $\"[525-547]T$ $\"[558-568]T$	TRNASYNTHLEU
PTHR11946:SF7	$\"[4-206]T$ $\"[234-568]T$ $\"[608-832]T$	Leu_tRNAsyn_1a
TIGR00396	$\"[4-833]T$	leuS_bact

InterPro
IPR009008
Domain

ValRS-IleRS-LeuRS editing
SSF50677	$\"[226-412]T$	ValRS_IleRS_edit

InterPro
IPR009080
Domain

Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
SSF47323	$\"[651-833]T$	tRNAsyn_1a_bind

InterPro
IPR013155
Domain

tRNA synthetase, valyl/leucyl, anticodon-binding
PF08264	$\"[729-785]T$	Anticodon_1

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[30-619]T$	Rossmann-like_a/b/a_fold

InterPro
IPR015413
Domain

tRNA synthetase class I (M)
PF09334	$\"[41-153]T$ $\"[610-634]T$	tRNA-synt_1g

noIPR
unintegrated

unintegrated
G3DSA:1.10.730.10	$\"[628-768]T$	G3DSA:1.10.730.10
PTHR11946	$\"[4-206]T$ $\"[234-568]T$ $\"[608-832]T$	PTHR11946
SSF52374	$\"[1-659]T$	SSF52374

","BeTs to 13 clades of COG0495COG name: Leucyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0495 is amtkYQvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 414-504 are 76% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000647) which is seen in Q9CHB6_LACLA.Residues 701-801 are 66% similar to a (SYNTHETASE LIGASE LEUCYL-TRNA) protein domain (PD118334) which is seen in Q9CHB6_LACLA.Residues 9-90 are 87% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000389) which is seen in Q9CHB6_LACLA.Residues 404-513 are 31% similar to a (ZK524.3) protein domain (PD118452) which is seen in Q23511_CAEEL.Residues 227-308 are 51% similar to a (LIGASE SYNTHETASE LEURS ATP-BINDING) protein domain (PD392511) which is seen in SYL_TREPA.Residues 310-366 are 77% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD350559) which is seen in Q9CHB6_LACLA.Residues 367-413 are 63% similar to a (SYNTHETASE PROTEOME COMPLETE LEUCYL-TRNA) protein domain (PD378613) which is seen in Q9CHB6_LACLA.Residues 225-269 are 60% similar to a (SYNTHETASE LIGASE LEUCYL-TRNA) protein domain (PD399422) which is seen in SYL_MYCTU.Residues 568-608 are 85% similar to a (SYNTHETASE PROTEOME COMPLETE LEUCYL-TRNA) protein domain (PD373848) which is seen in Q9CHB6_LACLA.Residues 227-308 are 75% similar to a (SYNTHETASE LIGASE LEUCYL-TRNA) protein domain (PD409879) which is seen in Q9CHB6_LACLA.Residues 517-567 are 92% similar to a (SYNTHETASE LIGASE LEUCYL-TRNA) protein domain (PD403220) which is seen in Q9CHB6_LACLA.Residues 97-158 are 87% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD002670) which is seen in Q9CHB6_LACLA.Residues 609-694 are 83% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000476) which is seen in Q9CHB6_LACLA.Residues 319-397 are 69% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD004139) which is seen in SYL_BACSU.Residues 683-831 are 33% similar to a (SYNTHETASE LIGASE LEUCYL-TRNA ATP-BINDING) protein domain (PD346307) which is seen in SYL_HELPJ.Residues 678-781 are 30% similar to a (ZK524.3 CG7479) protein domain (PD253824) which is seen in Q23511_CAEEL.Residues 454-509 are 53% similar to a (LIGASE SYNTHETASE LEURS ATP-BINDING) protein domain (PD388240) which is seen in SYL_TREPA.Residues 162-224 are 57% similar to a (LIGASE SYNTHETASE LEURS ATP-BINDING) protein domain (PD386284) which is seen in SYL_MYCLE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 10:39:21 2006","Thu Aug 24 10:39:21 2006","Thu Aug 24 10:39:21 2006","Fri Mar 1 18:31:43 2002","","Fri Mar 1 18:31:43 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1766 is paralogously related (blast p-value < 1e-3) to SMu0508, isoleucine-tRNA synthetase, SMu1611, valyl-tRNA synthetase, and SMu1492.","Fri Mar 1 18:52:23 2002","Thu Aug 24 10:39:21 2006","pdb1FFYA Chain A, Insights Into Editing From An Ile-Trna Synt... 99 2e-021pdb1ILE Isoleucyl-Trna Synthetase 92 3e-019pdb1GAXA Chain A, Crystal Structure Of Thermus Thermophilus V... 81 5e-016","SMU.1943c","","Residues 12 to 650 (E-value = 3.4e-209) place SMu1766 in the tRNA-synt_1 family which is described as tRNA synthetases class I (I, L, M and V) (PF00133)","Fri Mar 1 18:31:43 2002","","","","","","","1","","","SMU.1943c","193" "SMu1767","1824905","1825669","765","ATGTTAAATGAAACTATCCAAAAAGAATTCCAAAGAAAAGAAATCAAATATTTAATTGAAGCTGACACCTTTGAACAATTACAAAAAGAATTTAAAGATTATCTTACTCCGGATCGCTTCACTCATTCCTCCATTACTAATATTTATTTTGATAATCCCGACTTTCAATTGATTAAGGATTCAATCAACCACCGCCATGCCAGTGAAAAAATTAGAATGCGTACCTATGACCCAAAACCTACTCAAAAAAGTCAAGCTTTTTTAGAAATCAAGAAAAAAGAATATCAGGGTGAACAAGAAATCGGTTATAAATACCGTCTGACGTCCACCCCTTTGTCTCTTTGCAATTATGTTCAGCAAGGAATAATTGACAATAACATAAAACAAGATGACAGAGCTAATCATGAGCTTGCTATTTTACGAGAACGTTATAAAAAACTAGTACCAAAAATGTTCATTCACTATGAACGCTTTTCACTAAGGGGAATTGAAAATCCTAAACTTCGCGTTACTTTTGACCGCAATGTTATTTATCGCCACGAAAATGTTAATCTCACTTCGGGTTTTAATGGTTATCCACTTCTAAAAAACAATCAAATCGTTATGGAAATCAAAGTTAAAAATGGGCTTCCTGCTTGGATGGAAAAAATATTCCATAAACACCAGCTAATTCCACAATCTTTTTCAAAGTATACCACTGCCTATTTAAAGGCTTATGGACTAACACCTGAAGATATCAGAGAGGAGCCTACGTCAATTGCTTAA","10.00","8.89","30290","MLNETIQKEFQRKEIKYLIEADTFEQLQKEFKDYLTPDRFTHSSITNIYFDNPDFQLIKDSINHRHASEKIRMRTYDPKPTQKSQAFLEIKKKEYQGEQEIGYKYRLTSTPLSLCNYVQQGIIDNNIKQDDRANHELAILRERYKKLVPKMFIHYERFSLRGIENPKLRVTFDRNVIYRHENVNLTSGFNGYPLLKNNQIVMEIKVKNGLPAWMEKIFHKHQLIPQSFSKYTTAYLKAYGLTPEDIREEPTSIA","1825679","","conserved hypothetical protein","Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1555 (1e-11).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 16:41:11 2002","Tue Mar 13 10:27:18 2007","Tue Mar 13 10:27:18 2007","Fri Mar 1 18:30:41 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1767 is paralogously related (blast p-value < 1e-3) to SMu1773, a predicted conserved hypothetical protein.","Mon Apr 15 16:41:11 2002","","No significant hits to the NCBI PDB database.","SMU.1945","","No significant hits to the Pfam 11.0 database","Fri Mar 1 18:30:41 2002","24380293","","","","","","1","","","SMU.1945","" "SMu1768","1825662","1826351","690","TTGCTTAATCAGATTTTTAACAGTGTTTTCTCAAATCGAGATATTACTATTAGTCCCAGCATGTTCGCCTTATCTATCTTAACCAGCCTGCTTTTAGGATTGTTACTGGCTAAAATTTATAAATACAAGACTATCTATACTAAAGAATTCATTATTACCTTGGCTACCTTGCCTGTACTCATTTCCATGATTATTTTTCTTGTTAATGGTAATTTAGGAACCAGTGTCGCTGTTGCAGGAACTTTTGGTCTGATTCGTTTTCGTTCAGCTGCAGGCGGTGCTAAAGAAATTCTTTATATTTTCTTTGCAACTGCTGTTGGTATTGCAACAGGTATGGGCTTTCTTGTCCTAGCCATCCTGTTTACCTTGACCTTGACCCTTGTGCTTTGGCTTTATGAGAATTCAGGATTTTCACAGGTCAGCACAAGCAGGCGACAGGCAACTTTTATTGTTCCTAATAATGAGATTGATTATATCCCTATTCTGGAAAAAATCCTAAACAAAACTTGCCGTGAAATAAATCTCATTTCTGTTAAAAACATTAACAAAAACAACACCATTCAAATGGAATATCATTTAGACTTAAAACCAGAAATGAATGACATAGGACTTATCAATAGTATCATGACTTACAACCCTGATATTGAAGTCACTCTTGATACCAGTGCCAAAAAAAAGAAAATTTTATGA","10.00","5.18","25468","MLNQIFNSVFSNRDITISPSMFALSILTSLLLGLLLAKIYKYKTIYTKEFIITLATLPVLISMIIFLVNGNLGTSVAVAGTFGLIRFRSAAGGAKEILYIFFATAVGIATGMGFLVLAILFTLTLTLVLWLYENSGFSQVSTSRRQATFIVPNNEIDYIPILEKILNKTCREINLISVKNINKNNTIQMEYHLDLKPEMNDIGLINSIMTYNPDIEVTLDTSAKKKKIL","1826361","","conserved hypothetical protein","Membrane, Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1554 (4e-07).","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[21-167]T$	no description

noIPR
unintegrated

unintegrated
signalp	$\"[1-37]?$	signal-peptide
tmhmm	$\"[19-39]?$ $\"[44-66]?$ $\"[72-87]?$ $\"[97-131]?$	transmembrane_regions

InterPro
IPR001062
Family

Bacterial transcription antitermination protein NusG
PR00338	$\"[60-72]T$ $\"[154-170]T$	NUSGTNSCPFCT
PF02357	$\"[6-107]T$	NusG
TIGR00922	$\"[8-178]T$	nusG

InterPro
IPR003257
Domain

Bacterial NusG ribosomal protein
PD005267	$\"[66-164]T$	Ribosomal_NusG

InterPro
IPR005824
Domain

KOW
PF00467	$\"[127-160]T$	KOW

InterPro
IPR006645
Domain

NGN
SM00738	$\"[5-116]T$	NGN

InterPro
IPR006646
Domain

KOW (Kyrpides, Ouzounis, Woese) motif
SM00739	$\"[126-153]T$	KOW

InterPro
IPR008991
Domain

Translation protein SH3-like
SSF50104	$\"[123-178]T$	Transl_SH3_like

noIPR
unintegrated

unintegrated
G3DSA:3.30.70.940	$\"[5-120]T$	G3DSA:3.30.70.940
SSF82679	$\"[5-119]T$	SSF82679

","BeTs to 15 clades of COG0250COG name: Transcription antiterminator NusG/RfaHFunctional Class: KThe phylogenetic pattern of COG0250 is amtkyqvcEbrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001062 (Bacterial transcription antitermination protein, nusG) with a combined E-value of 1.2e-49. IPB001062A 8-22 IPB001062B 44-93 IPB001062C 127-143 IPB001062D 143-177***** IPB000302 (Ribosomal protein L24/bacterial NUSG) with a combined E-value of 3.9e-07. IPB000302A 127-161***** IPB003257 (Bacterial NUSG) with a combined E-value of 2.3e-06. IPB003257B 127-161","Residues 5-142 are 67% similar to a (TRANSCRIPTION ANTITERMINATION PROTEOME) protein domain (PD003474) which is seen in Q9CDV7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 13:29:06 2002","Fri Mar 1 18:26:50 2002","Tue Oct 15 13:29:06 2002","Fri Mar 1 18:26:50 2002","Fri Mar 1 18:26:50 2002","Fri Mar 1 18:26:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1769 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Apr 10 09:52:36 2002","","No significant hits to the NCBI PDB database.","SMU.1947c","","Residues 5 to 48 (E-value = 1.2e-17) place SMu1769 in the NusG family which is described as Transcription termination factor nusG (PF02357)Residues 127 to 160 (E-value = 2.2e-08) place SMu1769 in the KOW family which is described as KOW motif (PF00467)","Fri Mar 1 18:26:50 2002","","","","","","","1","","","SMU.1947c","607" "SMu1770","1827436","1827260","177","ATGAAATTCATTGGTGGCGTTTTTTCAGTTCTAAAGCATACGACATGGCCAACACGTAAACAATCTTGGCATGATTTTATTTCAATTCTGGAGTATTCAGCATTCTTTGCTCTTGTCATCTTTATTTTTGATAAGCTGTTAACTCTGGGATTGGCTGAATTATTAAAACGTTTTTAA","10.50","3.46","6805","MKFIGGVFSVLKHTTWPTRKQSWHDFISILEYSAFFALVIFIFDKLLTLGLAELLKRF","1827276","","preprotein translocase, SecE subunit","Membrane, Cytoplasm","Two very weak hits in gapped BLAST to a hypothetical protein (gi15675826) of S pyogenes and a preprotein translocase, SecE subunit (gi15901831) of S. pneuomoniae.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2064 (5e-15).","

InterPro
IPR005807
Family

SecE subunit of protein translocation complex
TIGR00964	$\"[1-56]T$	secE_bact

","BeTs to 4 clades of COG0690COG name: Preprotein translocase subunit SecEFunctional Class: NThe phylogenetic pattern of COG0690 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 2-44 are 55% similar to a (PROTEOME SECE TRANSLOCASE SUBUNIT) protein domain (PD386349) which is seen in Q9CDV6_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon May 6 10:42:53 2002","Tue Sep 5 08:53:57 2006","Tue Sep 5 08:53:57 2006","Fri Mar 1 18:17:32 2002","","Fri Mar 1 18:17:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1770 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon May 6 10:42:53 2002","","No significant hits to the NCBI PDB database.","SMU.1948c","","No significant hits to the Pfam 11.0 database","Fri Mar 1 18:17:32 2002","","","","","","","1","","","SMU.1948c","1025" "SMu1771","1829843","1827651","2193","ATGCCTCAAAATCTTGATAATCAAGCTAGCCAAGCCTCTGACAACCATTATCACCGTCGCCATGCACAGGAAGAGGCTAGTAAATTCAGCAACATTTTGAGCAAGATAGGTCTTTCTAAAAATGGTTTGGTTAGAAGATATTGGCGCCGTTATCATGTCGGTAAGATTTTGCTGATTGCGGTAGGTATTTTTGTACTTTTGACAGGCTCTTATCTGTTTTATCTAGCTAAGACAACCAAAGTTTCTGATTTAAAACAGGCTTTGAAGGCAACAACGGTCATTTATGATAAAAATGAAAAACAAGCTGGAACTCTTTATGGGCAAAAGGGGACTTATGTTGAACTTGATGCTATTTCCGACGATTTAGAAAATGCAGTGATTTCAACAGAAGACAGAAGCTTCTATAAAAATAGTGGCATCAATTACAAGCGGATGCTTTTAGCGATAGTTACCTTAGGTTATTCGGGCGGAGGATCTACCATTACACAGCAATTGGCTAAAAATGCCTTTTTAACCCAAGAACAAACAGTTAAAAGAAAAGCACGCGAGTTTTTCCTCGCTCTGGAATTGACCAAAAAATATAGTAAAAAAGAAATTTTAACCATGTATCTTAACAATGCCTACTTTGGTAATGGTGTTTGGGGGGTCGAAGATGCTAGTCAAAAGTATTTTGGAACTTCTGCTAGTCGGCTGACACTTGATGAGGCAGCTACTTTGGCAGGTATGTTGAAGGGTCCGGGTATCTACAATCCACTGTATTCTATTGAGAATGCGACCAGTCGACGCGATACTGTCCTGCAAAATATGGTGGCTGCGGGGAAAATATCGCAGAAACAGGCCAATGAGGCTAAAAAAGTGGGAATGGGGAACCGTATAAGTGATACTTATGTTGCTAAGACAGATGATTATCAATATCCATCTTATTTTGATGCTGTTATTAGTGAGGCTAGCTCTGTCTATGGTATCAGTGAAAAAGACATTGTTAACAATGGTTATAGGATTTACACTGAATTAGACCAGAATTACCAAACTGGCATGCAGCAAACCTTTGATGAGGAAAGTCTCTTTCCTGTATCCACTTATGATAATACCAGTGCTCAAGCTGCTAGCGTGGCTTTGGATCCTAAAACAGGTGGTGTTAGAGGCTTAGTTGGACGTGTTAATAGCACAAAAAATGTTACTTTTAGAAATTATAACTATGCGACTCAGTCTAATAGAAGTCCGGGTTCAACGATTAAACCACTAGCTGTTTATACTCCCGCAATCGCTTCAGGCTGGTCTATGGATAAACTATTACCCAATACTTCCCGTGATTTTGATGGTTACAAACCCAATAACTATGGAAATATTGAAACAGAAGACATTCCTATGTATCAGGCACTAGCCAATTCCTATAACATTCCTGCTGTTTATACGCTTGATAAATTGGGTATCAATAAGGCGTTTTCTTATGGTAAAAAGTTTGGTCTTAATATGGATGCTGCTAAAAAAGAATTAGGTGTTGCTTTGGGAGGAAGCGTCACAACTAATCCACTTGAGATGGCTCAGGCTTATGCAACATTTGCTAATGGAGGCGTGATGCCAACTGCTCACTTGATTAGTCGCATTGAAACTGCCAGCGGTGAAATTTTGAAGAAATTCACACCTAATGATAAACGTGTTATCAGTAAATCTGTGGCAGACAAAATGACTAGTATGATGTTAGGAACTTTTTCTAACGGGACTGGTGTCAATGCCAATGCTTATGGTTATACTTTAGCCGGTAAGACAGGAACAACTGAAACGAATTTTGATTCTAATCTTGCCAGTGACCAGTGGGTGATTGGTTATACACCTGATGTGGTTATTAGTCAATGGTTAGGTTTTAATAAGACTGATGAAAATCACTATTTGAATGATTCTAGTTCAGGAACGGCTTCCAATATCTTTAGCACTCAGGCAAGTTACATTTTACCCTATACTAAAGGAACAGAATTTAAGGTTAAAAATGCTTATTTCCAAGACGGCATTAAATCTACCTATGATTCAGATGATACTTCGGATGAAACTAATTCTAATTCCCAAAATATCATTGATGGTATTCGCGAGAAAGCTCAAAATGCTACGGATTCTATTAAGAAAAAAGTGGATGATTCAAATATTATTGATAAGGCCAAGAAAGTTTGGGATAGTGTTGTGAATTATTTTGAATAA","9.50","6.49","80546","MPQNLDNQASQASDNHYHRRHAQEEASKFSNILSKIGLSKNGLVRRYWRRYHVGKILLIAVGIFVLLTGSYLFYLAKTTKVSDLKQALKATTVIYDKNEKQAGTLYGQKGTYVELDAISDDLENAVISTEDRSFYKNSGINYKRMLLAIVTLGYSGGGSTITQQLAKNAFLTQEQTVKRKAREFFLALELTKKYSKKEILTMYLNNAYFGNGVWGVEDASQKYFGTSASRLTLDEAATLAGMLKGPGIYNPLYSIENATSRRDTVLQNMVAAGKISQKQANEAKKVGMGNRISDTYVAKTDDYQYPSYFDAVISEASSVYGISEKDIVNNGYRIYTELDQNYQTGMQQTFDEESLFPVSTYDNTSAQAASVALDPKTGGVRGLVGRVNSTKNVTFRNYNYATQSNRSPGSTIKPLAVYTPAIASGWSMDKLLPNTSRDFDGYKPNNYGNIETEDIPMYQALANSYNIPAVYTLDKLGINKAFSYGKKFGLNMDAAKKELGVALGGSVTTNPLEMAQAYATFANGGVMPTAHLISRIETASGEILKKFTPNDKRVISKSVADKMTSMMLGTFSNGTGVNANAYGYTLAGKTGTTETNFDSNLASDQWVIGYTPDVVISQWLGFNKTDENHYLNDSSSGTASNIFSTQASYILPYTKGTEFKVKNAYFQDGIKSTYDSDDTSDETNSNSQNIIDGIREKAQNATDSIKKKVDDSNIIDKAKKVWDSVVNYFE","1827667","For other 'pbp' genes see SMu0544 (pbp2b); SMu0811 (pbpX); SMu1808 (pbp1b); SMu0412 (pbp2X) and SMu0424 (pbp1a).","penicillin-binding protein 2a","Extracellular","Numerous strong significant hits in gapped BLAST to penicillin-binding protein 2a; residues 44-729 are 73% similar to penicillin-binding protein 2a of Streptococcus pyogenes (gi|15675827); residues 38-729 are 60% similar to penicillin-binding protein 2a of Streptococcus pneumoniae (gi|15903865).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2066 (0.0).","

InterPro
IPR001264
Domain

Glycosyl transferase, family 51
PD001895	$\"[176-231]T$	Glyco_trans_51
PF00912	$\"[92-255]T$	Transgly

InterPro
IPR001460
Domain

Penicillin-binding protein, transpeptidase
PF00905	$\"[368-644]T$	Transpeptidase

InterPro
IPR011816
Domain

Penicillin-binding protein 1A
TIGR02074	$\"[109-653]T$	PBP_1a_fam

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[337-655]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[365-647]T$	G3DSA:3.40.710.10

","BeTs to 10 clades of COG0744COG name: Membrane carboxypeptidase (penicillin-binding protein)Functional Class: MThe phylogenetic pattern of COG0744 is -----qvCEBRHuj--ol--xNumber of proteins in this genome belonging to this COG is 3","***** IPB001264 (Glycosyltransferase family 51) with a combined E-value of 6.5e-59. IPB001264A 113-152 IPB001264B 157-209 IPB001264C 214-240***** IPB001460 (Penicillin binding protein transpeptidase domain) with a combined E-value of 7.2e-10. IPB001460B 336-344 IPB001460C 510-525","Residues 44-92 are 53% similar to a (2A PENICILLIN-BINDING PROTEOME COMPLETE) protein domain (PD082060) which is seen in Q9RQJ1_STRPN.Residues 586-636 are 49% similar to a (1A PENICILLIN-BINDING SYNTHESIS ALL) protein domain (PD137205) which is seen in PBPF_BACSU.Residues 499-650 are 28% similar to a (PENICILLIN-BINDING) protein domain (PD312654) which is seen in Q9EXH0_BBBBB.Residues 256-373 are 59% similar to a (PENICILLIN-BINDING PROTEOME COMPLETE 2A) protein domain (PD170292) which is seen in Q9RQJ1_STRPN.Residues 93-253 are 72% similar to a (PENICILLIN-BINDING COMPLETE PROTEOME PEPTIDOGLYCAN 1A) protein domain (PD001895) which is seen in Q9CDV3_LACLA.Residues 397-490 are 58% similar to a (PENICILLIN-BINDING PROTEOME COMPLETE CELL PEPTIDOGLYCAN) protein domain (PD000435) which is seen in Q9RQJ1_STRPN.Residues 377-493 are 29% similar to a (1B PROTEOME PENICILLIN-BINDING COMPLETE) protein domain (PD407520) which is seen in Q9X6W0_PSEAE.Residues 589-670 are 63% similar to a (2A PENICILLIN-BINDING PROTEOME COMPLETE) protein domain (PD407062) which is seen in Q9RQJ1_STRPN.Residues 511-576 are 71% similar to a (PENICILLIN-BINDING COMPLETE PROTEOME 1A) protein domain (PD186125) which is seen in Q9RQJ1_STRPN.Residues 376-492 are 36% similar to a (PROTEOME COMPLETE 1B PENICILLIN-BINDING) protein domain (PD396802) which is seen in Q9CIH4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 10:55:31 2002","Fri Mar 1 18:10:56 2002","Tue Oct 15 10:55:31 2002","Fri Mar 1 18:10:56 2002","Fri Mar 1 18:10:56 2002","Fri Mar 1 18:10:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1771 is paralogously related (blast p-value < 1e-3) to SMu0424, penicillin-binding protein 1a, SMu1808, penicillin-binding protein 1b, and SMu0544, penicillin-binding protein 2b.","Fri Mar 1 18:13:17 2002","","No significant hits to the NCBI PDB database.","SMU.1949c","","Residues 92 to 255 (E-value = 2.4e-80) place SMu1771 in the Transgly family which is described as Transglycosylase (PF00912)Residues 368 to 644 (E-value = 2.4e-39) place SMu1771 in the Transpeptidase family which is described as Penicillin binding protein transpeptidase domain (PF00905)","Fri Mar 1 18:10:56 2002","","","","","","","1","","","SMU.1949c","194" "SMu1772","1829971","1830837","867","ATGACTTTTACTGTAAAAATTATAAACCCATATCCTATAGGGACTGTCAAGGAACTATTAGAAGAGCATTTTTTAATCCCAAGAAAGATCAGGCACTTTCTAAGAATAAAAAAGAATGTCACAGTTAATAGTCAAGCCGTCAATTGGCAAAGTCTTGTCAGGCGGGGAGATATTATCCAGCTGAACTTTGATAACACAGACTATCCTATCAAGAAAATTCCTATGGGAAACAAGACTTTAATAGACTGTCTCTACCAAGATGAACATCTTATTATTGTCAATAAAATAGAAGGCATGAAAACACATGCTAATGACCCCAATGAAATCGCACTTCTCAATCATGTTTCTGCTTATGTCGGACAGACCTGCTATGTTGTTCATCGACTTGATATGAAAACCAGCGGTACTGTCATGTTTGCTAAGAATCCATTTATCCTGCCGATCCTTAATCGTCTTTTAGAAAATAAGTCTATCAAACGCGAATACTGGGCTTTAGCACAAGGTCAATTTTCTGAACATGCAATTATTTATAGGGAGCCAATTGGACGCGATCGTCATGATCGACGTAAACGAGTTGTGGATCATAAGCATGGCCAGACAGCTATCACTCAGGTTTCACTCTTAAAGCATTTCTCCAATAATACCAGCCTGATCAAATGCCAACTTCAAACAGGACGAACCCACCAAATCCGTGTCCATCTAGCCTATCATGATCATGCCATTGTTGGCGATCCCCTATACAGTCAGCAAACAGCTGGTAGACTCATGCTGCATGCTCACCAGTTAACCTTTACTCATCCTCTTACACTTGAAAAAATTAAGGTTGAAGCTCCATCTGCAACATTTGAAAAGGGACTTCCTAAATAG","10.50","18.18","33223","MTFTVKIINPYPIGTVKELLEEHFLIPRKIRHFLRIKKNVTVNSQAVNWQSLVRRGDIIQLNFDNTDYPIKKIPMGNKTLIDCLYQDEHLIIVNKIEGMKTHANDPNEIALLNHVSAYVGQTCYVVHRLDMKTSGTVMFAKNPFILPILNRLLENKSIKREYWALAQGQFSEHAIIYREPIGRDRHDRRKRVVDHKHGQTAITQVSLLKHFSNNTSLIKCQLQTGRTHQIRVHLAYHDHAIVGDPLYSQQTAGRLMLHAHQLTFTHPLTLEKIKVEAPSATFEKGLPK","1830847","For other 'rlu' genes see SMu0580 (rluB); SMu0778 (rluD); SMu0953 (rluE) and SMu1559 (rluB).","ribosomal large subunit pseudouridine synthase D","Cytoplasm","Many strong and moderate significant hits in gapped BLAST to ribosomal large subunit pseudouridine synthase D; residues 1-288 are 60% similar to Ribosomal large subunit pseudouridine synthase D of Streptococcus pneumoniae (gi14973521); residues 16-282 are 47% similar to pseudouridine synthase of Lactococcus lactis (gi15674094).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2067 (1e-103).","

InterPro
IPR006145
Domain

Pseudouridine synthase
PD001819	$\"[126-170]T$	PseudoU_synth
PF00849	$\"[89-236]T$	PseudoU_synth_2

noIPR
unintegrated

unintegrated
PTHR10436	$\"[7-278]T$	PTHR10436
SSF55120	$\"[81-278]T$	SSF55120

","BeTs to 13 clades of COG0564COG name: Predicted pseudouridylate synthase family 2Functional Class: JThe phylogenetic pattern of COG0564 is ----YqVCEBRHUJGPOLINXNumber of proteins in this genome belonging to this COG is 3","***** IPB000613 (Pseudouridine synthase) with a combined E-value of 6.7e-47. IPB000613A 83-103 IPB000613B 126-165 IPB000613C 224-248 IPB000613D 254-267***** IPB002990 (Pseudouridine synthase, Rlu family) with a combined E-value of 6.4e-39. IPB002990A 83-103 IPB002990B 126-164 IPB002990C 224-248","Residues 82-182 are 57% similar to a (SYNTHASE PSEUDOURIDINE COMPLETE PROTEOME RIBOSOMAL) protein domain (PD001819) which is seen in Q9CDU9_LACLA.Residues 198-247 are 52% similar to a (SYNTHASE COMPLETE PROTEOME PSEUDOURIDINE RIBOSOMAL LARGE) protein domain (PD224882) which is seen in Q9PJ89_CAMJE.Residues 16-80 are 46% similar to a (PROTEOME COMPLETE PSEUDOURIDINE SYNTHASE) protein domain (PD390854) which is seen in Q9CDU9_LACLA.Residues 198-267 are 52% similar to a (SYNTHASE PROTEOME COMPLETE PSEUDOURIDINE RIBOSOMAL LARGE) protein domain (PD350148) which is seen in Q9CDU9_LACLA.Residues 84-169 are 33% similar to a (COMPLETE PROTEOME SYNTHASE PSEUDOURIDINE) protein domain (PD414934) which is seen in Q9PJ89_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 16:56:44 2006","Fri Mar 1 17:59:28 2002","Tue Sep 19 16:56:44 2006","Fri Mar 1 17:59:28 2002","Fri Mar 1 17:59:28 2002","Fri Mar 1 17:59:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1772 is paralogously related (blast p-value < 1e-3) to SMu0778, pseudouridylate synthase, and SMu0953, pseudouridine synthase.","Fri Mar 1 18:01:44 2002","","No significant hits to the NCBI PDB database.","SMU.1950","","Residues 89 to 236 (E-value = 4.7e-43) place SMu1772 in the PseudoU_synth_2 family which is described as RNA pseudouridylate synthase (PF00849)","Fri Mar 1 17:59:28 2002","24380298","","","","","","1","","","SMU.1950","492" "SMu1773","1832560","1830857","1704","ATGGATAGATTAAAAGAAAAGTGGCAGAAATACTTTAAAAAAGCACAAGAAACAGTGGCTACTCTTGTGGGGAAATTAAAGCAGCAGCTGCAAGATCTTCTTAAGAGAAAACCTATACGTACGACTTTAATTATTATAGGGAGCTTCTTTGTTCTTTTTGGATTATGGGGAAGTATTCATTATTCAAAAGCAGCTACCCTTGATCGTTATTTAAAGGCTAGAAGTGCTTCTGGTCATACTTTTGAAAATATTAAAGAGTATATGGTTTGGGATGATACGAATGAATTGATAACCAACGATGAGGCTCAATATACAAAGTTTTCACGTCTGAAGACAAGTTTAAAAAAACGCAGTCTCCGACAGAAACTATTATCAGCAAAAGCTTCGGATAAACTCTATCTCAAAAGTATTGGCCATAAATTTTTCTTTTTTCCTGATTATCGTCTTGCCATGAAACCATTGAAATTAACATTAAAGACGAATGTTTCAGGCTTAGATGTTCTTTTAAATGGTAAAAAAATTGCTACTAGTGATTCAGATAATTATCATGTTACGGTTACGCACTTACCCATAGATAATTATACCTTTACTCTTGATGGTATCCATAATGGTAAAGAGGTGGAATTTAATAAAAATTATGATGGTAAACATCAGACGGTTAATATGAACTTAGCCTTCAAAAACTTTACAGTTAAGAGCAATTTATCTGATGGAAATCTTTATTTTGGTAAAAAGAAAATTTCTTCCCTCTCAAATGGACAATATAATGTTGATAATTATCCTATTATGGGAAGCAAATCGGTTTATGTTAAGAAAAATTTTTCAGATGGGACAATCAAGTCTAACAAGCAATCTCTAAAGGATATTGCAGACGGCAGCACAGTTCAGCTTGATGTTCCTAATCAGTTGAATCAGGATACAGCTCAGCAACTATTAAATACTGCTTTTGAAAAATTTTCTGTTCATGCTAGTAATCAACAAGACCCAACAGATTTAAACACGGTTTTTGAAAATGGTTCTAATAATGATGTTTACAAGGCTTTAAAAGAGAGTATCAAGCAAAAAATGATGGTAGATAGTCGTAAGCCATCTAGCTTTACCATTACTTCGGTCAGTCTCAATGACTTACATCAAACAGGTATGAAAACTTATACTTTATCTTATGTTCTCACTTATGATTATTACTACGATGAAGCAACTGATCAAGAAAAGAAAACGTCAGGTCATTTGTTACAAAATATTACGGGACAGGTTCAAGTTAAAAAAACAGAGACTGGTTATACCATTCGTAAATCTATTAGTGGTCCGACAGTTGTCAGTGAAGACAATCAGGTGAAAAGTCCGACACCATTACCAGAAGAATTAATAGGAACTTGGGAAACGAAGCAAGATGATAAGACCGTTACCATGATCTTCTCAGAAGATGGTACAGTAACTAAAAAAACGGATTACAAGGACGATAAAAAAGAAGATACGACTAAGACAGCAAAAGTTGAAAAAACAGAAAAGACTTCAGATGGTACTTATCGCTATTACTATCAATCGGGGGATCGTGCTGCTCTTACCGTTTTAGATGACATCGGTGCTAATGATCAATACACTTATGGTGTTAAGATTAATGGCTCCAGTATAACGACTGTCTATTGGGAATCAGGCGATACCAGTGGCAGTCCTAAAACAGGCATTAGCTTAACTAAGAAATAA","10.10","17.44","64180","MDRLKEKWQKYFKKAQETVATLVGKLKQQLQDLLKRKPIRTTLIIIGSFFVLFGLWGSIHYSKAATLDRYLKARSASGHTFENIKEYMVWDDTNELITNDEAQYTKFSRLKTSLKKRSLRQKLLSAKASDKLYLKSIGHKFFFFPDYRLAMKPLKLTLKTNVSGLDVLLNGKKIATSDSDNYHVTVTHLPIDNYTFTLDGIHNGKEVEFNKNYDGKHQTVNMNLAFKNFTVKSNLSDGNLYFGKKKISSLSNGQYNVDNYPIMGSKSVYVKKNFSDGTIKSNKQSLKDIADGSTVQLDVPNQLNQDTAQQLLNTAFEKFSVHASNQQDPTDLNTVFENGSNNDVYKALKESIKQKMMVDSRKPSSFTITSVSLNDLHQTGMKTYTLSYVLTYDYYYDEATDQEKKTSGHLLQNITGQVQVKKTETGYTIRKSISGPTVVSEDNQVKSPTPLPEELIGTWETKQDDKTVTMIFSEDGTVTKKTDYKDDKKEDTTKTAKVEKTEKTSDGTYRYYYQSGDRAALTVLDDIGANDQYTYGVKINGSSITTVYWESGDTSGSPKTGISLTKK","1830873","","conserved hypothetical protein","Extracellular","One significant hit in gapped BLAST to a hypothetical protein; residues 39-567 are 38% similar to the hypothetical protein of S. pyogenes (gi|15675830).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2068 (1e-120).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[42-62]?$	transmembrane_regions

InterPro
IPR001844
Family

Chaperonin Cpn60
PR00298	$\"[26-52]T$ $\"[82-109]T$ $\"[266-289]T$ $\"[348-373]T$ $\"[396-417]T$	CHAPERONIN60
PS00296	$\"[403-414]T$	CHAPERONINS_CPN60

InterPro
IPR002423
Family

Chaperonin Cpn60/TCP-1
PR00304	$\"[24-40]T$ $\"[46-64]T$ $\"[80-99]T$ $\"[376-398]T$ $\"[409-421]T$	TCOMPLEXTCP1
PTHR11353	$\"[2-542]T$	Cpn60/TCP-1
PF00118	$\"[22-522]T$	Cpn60_TCP1

InterPro
IPR008950
Domain

GroEL-like chaperone, ATPase
SSF48592	$\"[9-519]T$	GroEL-ATPase

InterPro
IPR012723
Family

chaperonin GroEL
TIGR02348	$\"[2-524]T$	GroEL

noIPR
unintegrated

unintegrated
G3DSA:1.10.560.10	$\"[390-522]T$	G3DSA:1.10.560.10
G3DSA:3.50.7.10	$\"[172-374]T$	G3DSA:3.50.7.10
PTHR11353:SF10	$\"[2-542]T$	PTHR11353:SF10
SSF52029	$\"[182-374]T$	SSF52029
SSF54849	$\"[136-191]T$	SSF54849

","BeTs to 17 clades of COG0459COG name: Chaperonin GroEL (HSP60 family)Functional Class: OThe phylogenetic pattern of COG0459 is AmTkYqvCebRhujgpolINxNumber of proteins in this genome belonging to this COG is 1","***** IPB001844 (Chaperonin cpn60 (60Kd subunit)) with a combined E-value of 1.1e-209. IPB001844A 23-72 IPB001844B 169-223 IPB001844C 249-302 IPB001844D 343-394 IPB001844E 474-520 IPB001844A 54-103***** PR00304 (Tailless complex polypeptide 1 (chaperone) signature) with a combined E-value of 4.9e-62. PR00304A 24-40 PR00304B 46-64 PR00304C 80-99 PR00304D 376-398 PR00304E 409-421***** IPB002194 (Chaperonins TCP-1) with a combined E-value of 1.9e-11. IPB002194A 58-112 IPB002194B 474-518","Residues 451-514 are 90% similar to a (CHAPERONE ATP-BINDING CHAPERONIN CPN60 GROEL HEAT SHOCK) protein domain (PD000184) which is seen in CH60_STRPY.Residues 102-221 are 93% similar to a (CHAPERONE ATP-BINDING CHAPERONIN CPN60 GROEL HEAT SHOCK) protein domain (PD000186) which is seen in CH60_STRPY.Residues 1-101 are 26% similar to a (PROTEOME COMPLETE CHAPERONIN HSP-60) protein domain (PD344451) which is seen in Q9PJD6_CHLMU.Residues 444-514 are 40% similar to a (CHAPERONIN ATP-BINDING CPN60 GROEL) protein domain (PD391902) which is seen in CH60_XANMA.Residues 234-402 are 90% similar to a (CHAPERONE ATP-BINDING CHAPERONIN CPN60 GROEL HEAT SHOCK) protein domain (PD000354) which is seen in CH60_STRPY.Residues 31-101 are 76% similar to a (ATP-BINDING CHAPERONE CHAPERONIN CPN60 GROEL SHOCK HEAT) protein domain (PD403168) which is seen in O08500_BBBBB.Residues 2-30 are 89% similar to a (CHAPERONE ATP-BINDING CHAPERONIN CPN60 GROEL SHOCK HEAT) protein domain (PD340567) which is seen in CH60_STRPY.Residues 31-119 are 85% similar to a (CHAPERONE ATP-BINDING CHAPERONIN SUBUNIT CPN60 GROEL) protein domain (PD209943) which is seen in Q9KJV7_CLODI.Residues 10-225 are 23% similar to a (PROTEOME CHAPERONIN COMPLETE ATP-BINDING) protein domain (PD165916) which is seen in Q9Z708_CHLPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 26 09:42:29 2007","Fri Mar 1 17:41:06 2002","Tue Feb 1 11:11:26 2005","Fri Mar 1 17:41:06 2002","Fri Mar 1 17:41:06 2002","Fri Mar 1 17:41:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1774 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 11 11:06:01 2002","Tue Feb 1 11:11:26 2005","pdb1AONH Chain H, Crystal Structure Of The Asymmetric Chapero... 599 3e-172pdb1DERA Chain A, The 2.4 Angstrom Crystal Structure Of The B... 596 2e-171pdb1OELA Chain A, Mol_id: 1; Molecule: Groel (Hsp60 Class); C... 595 4e-171","SMU.1954c","","Residues 22 to 522 (E-value = 7.1e-195) place SMu1774 in the Cpn60_TCP1 family which is described as TCP-1/cpn60 chaperonin family (PF00118)","Fri Mar 1 17:41:06 2002","","","Teng LJ, Hsueh PR, Tsai JC, Chen PW, Hsu JC, Lai HC, Lee CN, Ho SW. groESL Sequence Determination, Phylogenetic Analysis, and SpeciesDifferentiation for Viridans Group Streptococci.J Clin Microbiol. 2002 Sep;40(9):3172-8.PMID: 12202549Lemos JA, Chen YY, Burne RA. Genetic and physiologic analysis of the groE operon and role of the HrcArepressor in stress gene regulation and acid tolerance in Streptococcus mutans.J Bacteriol. 2001 Oct;183(20):6074-84.PMID: 11567008 Hill JE, Penny SL, Crowell KG, Goh SH, Hemmingsen SM.cpnDB: a chaperonin sequence database.Genome Res. 2004 Aug;14(8):1669-75.PMID: 15289485Hung WC, Tsai JC, Hsueh PR, Chia JS, Teng LJ.Species identification of mutans streptococci by groESL gene sequence.J Med Microbiol. 2005 Sep;54(Pt 9):857-62.PMID: 16091437","","Thu Apr 26 09:42:29 2007","","1","","","SMU.1954c","196" "SMu1775","1835231","1834944","288","ATGTTAAAACCCTTAGGAGACCGAGTGGTCGTACAATTGAAAGAAGAAAAGGAACAAACAGTTGGTGGTTTTGTCCTTGCTGGTGCTAGTCAAGAAAAGACTAAAAAAGCTCAAGTAGTAGCTGTTGGTGAAGGTGTTCGTACTTTAACTGGGGAATTGGTTGCGTCCAGTTTAGTACAAGGCGATACTATTTTAATTGAAAATCATGTAGGAACGCCTGTTAAAGATGATGGTAAAGATTGCCTTATCATTCGTGAAGCAGATGTTTTAGCAGTTGTAAACGATTAA","4.70","-3.82","10022","MLKPLGDRVVVQLKEEKEQTVGGFVLAGASQEKTKKAQVVAVGEGVRTLTGELVASSLVQGDTILIENHVGTPVKDDGKDCLIIREADVLAVVND","1834960","For other 'gro' genes see SMu1774 (groEL).From GenBank (gi:584918): In L.lactis, groES binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. It is a subunit of a heptamer arranged in a ring. It belongs to the GroES chaperonin family of proteins.","co-chaperonin 10kDa","Cytoplasm","Several weak significant hits in gapped BLAST to chaperonins; residues 1-93 are 59% similar to 10kDa chaperonin of Streptococcus agalactiae (gi13123669); residues 1-95 are 61% similar to cochaperonin GroES of Streptococcus pneumoniae (gi15903765).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2075 (4e-29).","

InterPro
IPR001476
Family

Chaperonin Cpn10
PD000566	$\"[6-90]T$	Chaprnin_Cpn10
PR00297	$\"[2-17]T$ $\"[24-45]T$ $\"[59-71]T$ $\"[80-93]T$	CHAPERONIN10
G3DSA:2.30.33.40	$\"[2-95]T$	Chaprnin_Cpn10
PTHR10772	$\"[1-95]T$	Chaprnin_Cpn10
PF00166	$\"[1-93]T$	Cpn10
PS00681	$\"[2-26]T$	CHAPERONINS_CPN10

InterPro
IPR011032
Domain

GroES-like
SSF50129	$\"[1-95]T$	GroES_like

","BeTs to 13 clades of COG0234COG name: Co-chaperonin GroES (HSP10)Functional Class: OThe phylogenetic pattern of COG0234 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001476 (Chaperonins cpn10 (10 Kd subunit)) with a combined E-value of 8.2e-22. IPB001476A 2-20 IPB001476B 37-88","Residues 1-93 are 62% similar to a (CHAPERONIN GROES CHAPERONE CPN10 SHOCK HEAT CHLOROPLAST) protein domain (PD000566) which is seen in Q9X4R4_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 26 09:42:10 2007","Thu Sep 21 08:18:02 2006","Thu Sep 21 08:18:02 2006","Fri Mar 1 17:25:15 2002","Fri Mar 1 17:25:15 2002","Fri Mar 1 17:25:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1775 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Mar 1 17:28:36 2002","Thu Sep 21 08:18:02 2006","pdb1AONO Chain O, Crystal Structure Of The Asymmetric Chapero... 63 8e-012","SMU.1955c","","Residues 1 to 94 (E-value = 2.5e-27) place SMu1775 in the Cpn10 family which is described as Chaperonin 10 Kd subunit (PF00166)","Fri Mar 1 17:25:15 2002","","","Teng LJ, Hsueh PR, Tsai JC, Chen PW, Hsu JC, Lai HC, Lee CN, Ho SW. groESL Sequence Determination, Phylogenetic Analysis, and SpeciesDifferentiation for Viridans Group Streptococci.J Clin Microbiol. 2002 Sep;40(9):3172-8.PMID: 12202549Lemos JA, Chen YY, Burne RA. Genetic and physiologic analysis of the groE operon and role of the HrcA repressor in stress gene regulation and acid tolerance in Streptococcus mutans.J Bacteriol. 2001 Oct;183(20):6074-84.PMID: 11567008 Hung WC, Tsai JC, Hsueh PR, Chia JS, Teng LJ.Species identification of mutans streptococci by groESL gene sequence.J Med Microbiol. 2005 Sep;54(Pt 9):857-62.PMID: 16091437","","Thu Apr 26 09:42:10 2007","","1","","","SMU.1955c","984" "SMu1776","1835649","1835353","297","ATGCTAACAGAAAAAGAATTCATCAAAGGATATGAAAATGAAATCGCTTATCAAAAACATATGATTGAAAACCTAGGACGTTGGTTTACTTTAATGTTTATCATTGCTAGTATCGGTGTCGTTTTGATTTACTTATTCTCAGCTAATCTCGTTGGGTTTACTATTGGAATTGTTTTGACGGCCTTAGGATTCTTAGCTATGTTAGTCTTTGGTTATGGTATTTACAAGGGTCGCCTCAATGTTCAAAAAGTCGTTGATGATTTTGAAGAAAAACTGCGACTTGCCAATTCTAAATAA","9.10","1.23","11171","MLTEKEFIKGYENEIAYQKHMIENLGRWFTLMFIIASIGVVLIYLFSANLVGFTIGIVLTALGFLAMLVFGYGIYKGRLNVQKVVDDFEEKLRLANSK","1835369","","conserved hypothetical protein","Membrane, Cytoplasm","A single significant hit in gapped BLAST: residues 9-93 are 36% similar to gi|23023678, an hypothetical protein from Leuconostoc mesenteroides subsp. mesenteroides.SMu1776 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-71]?$	signal-peptide
tmhmm	$\"[29-47]?$ $\"[53-75]?$	transmembrane_regions

InterPro
IPR004704
Family

Phosphotransferase system, mannose/fructose/sorbose family IID component
PF03613	$\"[4-272]T$	EIID-AGA
PS51108	$\"[4-272]T$	PTS_EIID

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 29-270 are 29% similar to a (COMPONENT IID SYSTEM PHOSPHOTRANSFERASE) protein domain (PD013894) which is seen in PTND_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 21 15:14:17 2002","Fri Mar 1 17:03:10 2002","Mon Oct 21 10:33:03 2002","Fri Mar 1 17:03:10 2002","","Fri Mar 1 17:03:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1777 is paralogously related (blast p-value < 1e-3) to SMu1709, and SMu0091, PTS system, IID component.","Fri Mar 1 17:08:13 2002","","No significant hits to the NCBI PDB database.","SMU.1957c","","Residues 4 to 272 (E-value = 5e-104) place SMu1777 in the EIID-AGA family which is described as PTS system mannose/fructose/sorbose family IID component (PF03613)","Fri Mar 1 17:03:10 2002","","","Zeng L, Wen ZT, Burne RA,A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177","Erni,B., Zanolari,B. and Kocher,H.P. The mannose permease of Escherichia coli consists of three different proteins. Amino acid sequence and function in sugar transport, sugar phosphorylation, and penetration of phage lambda DNA. J. Biol. Chem. 262 (11), 5238-5247 (1987) PubMed: 2951378Rhiel,E., Flukiger,K., Wehrli,C. and Erni,B. The mannose transporter of Escherichia coli K12: oligomeric structure, and function of two conserved cysteines. Biol. Chem. Hoppe-Seyler 375 (8), 551-559 (1994) PubMed: 7811395","","Fri Mar 1 17:07:19 2002","1","","","SMU.1957c","" "SMu1778","1837362","1836511","852","ATGACAATTTCTTGGTTTCAAGCAGCCTTGCTAGGATTGTTTGCCTGTTTGTCTTCAATGCCTGGTCTTGGCGGTACAACAATTGGTAACTATACTTTGGGACGCCCTTTAGTCGGCGGCTTGGTTTGTGGACTTATCCTAGGAGACATTAAGACAGGTATTGTTTGCGGTGTTGCTATGCAACTTGTTTACATCGCTCTTGTAACACCCGGTGGTACTGTTTCTGCTGATGTGCGTGCAGTATCTTATATCGGTATCCCATTAGCAATGGTTGCGATTCATTCTCAAGGTTTATCAGCAACTTCATCAGATGCAGCCAACCTTGCTAAATCAATGGGAACCCTTGTAGGTACTATTGGTACAGTGCTTTTCTATGGTACTGCAACAATGAACCTTGTTTGGCAACACATTGGATGGCAAGCTGTTGAAAAAAGAGAATTCAAGAGACTCTATGTTGTAGACTGGGGACTTCCATGGATCTCGCATATCGTCTTTTCATTCATTCCTACATTGATTATGTGTAAATTAGGTGCAGATGCCGTTACTGCTCTTAAGAATGCTCTTCCAATGGATGGTATTCCAATGAAGACTCTCTTTACGGTGGGTTCACTTCTTCCATGTGTAGGGATTGCTATTTTATTAAAACAAATTGTTGAAAAAGCAGTTGACTTTATTCCATTCTTTGTTGGTTTCACTTTGGCAGCTTCACTTGGTTTAAACTTAGTATCATGTGCAGTCATTTCTTTAATTTTTGCAGTACTGTTCTATGAACTTGAAACAATAAAGAATATGAGAGCAACGGCTTCGGCTGAAGCTTCAGATTTCGATGACGATGATGAGGAGGATATTTAA","4.80","-5.57","29949","MTISWFQAALLGLFACLSSMPGLGGTTIGNYTLGRPLVGGLVCGLILGDIKTGIVCGVAMQLVYIALVTPGGTVSADVRAVSYIGIPLAMVAIHSQGLSATSSDAANLAKSMGTLVGTIGTVLFYGTATMNLVWQHIGWQAVEKREFKRLYVVDWGLPWISHIVFSFIPTLIMCKLGADAVTALKNALPMDGIPMKTLFTVGSLLPCVGIAILLKQIVEKAVDFIPFFVGFTLAASLGLNLVSCAVISLIFAVLFYELETIKNMRATASAEASDFDDDDEEDI","1836527","From GenBank (gi:126218): In B.subtilis, this protein is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system. The IICD domains contain the sugar binding site and the transmembrane channel; the IIA domain contains the primary phosphorylation site (the donor is phospho-HPR); IIA transfers its phosphoryl group to the IIB domain which finally transfers it to the sugar. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator.","fructose-specific Enzyme IIC component","Membrane, Cytoplasm","One strong significant hit in gapped BLAST to PTS system fructose-specific enzyme IIC component; residues 1-141 are 65% similar to this protein of Clostridium acetobutylicum (gi|15894738).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1949 (1e-10).","

InterPro
IPR004700
Family

Phosphotransferase system, sorbose-specific IIC subunit
PF03609	$\"[3-75]T$	EII-Sor
PS51106	$\"[3-254]T$	PTS_EIIC_TYPE_4

InterPro
IPR004720
Domain

Phosphotransferase system, sorbose subfamily IIB component
PD008332	$\"[9-149]T$	PTSIIB_sorb
G3DSA:3.40.35.10	$\"[1-161]T$	PTS_IIB_sorb
PF03830	$\"[2-154]T$	PTSIIB_sorb
PS51101	$\"[1-164]T$	PTS_EIIB_TYPE_4
SSF52728	$\"[1-164]T$	PTS_IIB_sorb

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-148 are 28% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE IIB) protein domain (PD008332) which is seen in Q48520_LACCU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 1 16:18:47 2002","Fri Mar 1 16:18:47 2002","Tue Oct 15 13:18:44 2002","Fri Mar 1 16:18:47 2002","","Fri Mar 1 16:18:47 2002","yes","Mon Oct 21 10:32:06 2002","SMu1779 is paralogously related (blast p-value < 1e-3) to SMu1707, a predicted PTS system, mannose-specific component IIAB and SMu0089, a predicted sorbose PTS system, IIB component.","Mon Apr 15 16:43:16 2002","Fri Mar 1 16:18:47 2002","pdb|1BLE| Phosphoenolpyruvate-Dependent Phosphotransferase Sy... 187 9e-049","SMU.1960c","","Residues 2 to 154 (E-value = 6.7e-10) place SMu1779 in the PTSIIB_sorb family which is described as PTS system sorbose subfamily IIB component (PF03830)","Fri Mar 1 16:18:47 2002","24380305","","Zeng L, Wen ZT, Burne RA,A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177","","","","1","","","SMU.1960c","" "SMu1780","1838679","1838248","432","ATGAAATACCTATTGCTTGTAAGCCATGGCGGTTTTGCGCAGGGCTTAAAGACTTCTTTAGCTATGTTTGCTGAGGATAAAGTAAGTCAAGTTATAGCTGTCGGATTGGAAAATGGTAAATCAGTAGATGATTTTGCGGAAACTTTTAGACAAGCTCTTTCTAATCTAAAGGATGAGGATTCAGTTGTTGTTTTAGCTGATATTGTCGGGGGAAGCCCTTTGACAACAGCTTGCAATGTTTTAGCGGATTTGGGTAAGTTAGATGACGCCATTGTCTTAGGGGGGATGAACTTACCAATGGCAGTCAATGCTGTTGTTATGAAAGATATGCTTGAAGGTCAGGATTTTGTAACCACTGTTTTGGGTGAAGCTAAAAGCGCCTTACAAGAATTTAGGGTAACTTCTGATGAAGAAGATGATGATGACATTTAA","3.90","-14.81","15168","MKYLLLVSHGGFAQGLKTSLAMFAEDKVSQVIAVGLENGKSVDDFAETFRQALSNLKDEDSVVVLADIVGGSPLTTACNVLADLGKLDDAIVLGGMNLPMAVNAVVMKDMLEGQDFVTTVLGEAKSALQEFRVTSDEEDDDDI","1838264","From GenBank (gi:126218): In B.subtilis, this protein is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system. The IICD domains contain the sugar binding site and the transmembrane channel; the IIA domain contains the primary phosphorylation site (the donor is phospho-HPR); IIA transfers its phosphoryl group to the IIB domain which finally transfers it to the sugar. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator. LevD, a cytoplasmic protein, catalyzes the reaction: protein N-phosphohistidine + sugar = protein histidine + sugar phosphate.","fructose-specific Enzyme IIA component","Cytoplasm","One moderate and several weak significant hits in gapped BLAST to PTS fructose-specific enzyme IIA components; residues 1-141 are 43% similar to PTS system, fructose-specific IIA component of Clostridium acetobutylicum (gi|15894736); residues 4-129 are 28% similar to PTS system, fructose-specific IIA component of Bacillus subtilis (gi|16079761).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0361 (1e-10).","

InterPro
IPR004701
Domain

Phosphotransferase system, fructose subfamily IIA component
G3DSA:3.40.50.510	$\"[1-138]T$	PTS_EIIA_fruc
PF03610	$\"[2-121]T$	EIIA-man
PS51096	$\"[1-128]T$	PTS_EIIA_TYPE_4
SSF53062	$\"[1-132]T$	PTS_EIIA_fruc

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-110 are 30% similar to a (COMPONENT SYSTEM COMPLETE PROTEOME) protein domain (PD328938) which is seen in Q9S4L5_STRSL.Residues 1-116 are 27% similar to a (SYSTEM PTS N DOMAIN) protein domain (PD009343) which is seen in Q9KIQ1_ECOLI.Residues 4-120 are 29% similar to a (COMPONENT SYSTEM IIA PHOSPHOTRANSFERASE) protein domain (PD403187) which is seen in PTFA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 1 16:11:35 2002","Fri Mar 1 16:00:53 2002","Tue Oct 15 13:19:01 2002","Fri Mar 1 16:00:53 2002","","Fri Mar 1 16:00:53 2002","yes","Mon Oct 21 10:27:04 2002","SMu1780 is paralogously related (blast p-value < 1e-3) to SMu1707, predicted PTS system, mannose-specific component IIAB.","Mon Apr 15 08:26:43 2002","","No significant hits to the NCBI PDB database.","SMU.1961c","","Residues 2 to 121 (E-value = 4e-24) place SMu1780 in the EIIA-man family which is described as PTS system fructose IIA component (PF03610)","Fri Mar 1 16:00:53 2002","24380306","","Zeng L, Wen ZT, Burne RA,A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177","Martin-Verstraete,I., Debarbouille,M., Klier,A. and Rapoport,G. Levanase operon of Bacillus subtilis includes a fructose-specific phosphotransferase system regulating the expression of the operon. J. Mol. Biol. 214 (3), 657-671 (1990) PubMed: 2117666.","","Fri Mar 1 16:02:38 2002","1","","","SMU.1961c","" "SMu1781","1840289","1838982","1308","ATGATTAAAAAACGGCTTTACCAGTATAAATTTCACCTATTGGTCTTGTTGGTACTTTTAGGAGCCCTGTTAACCTTATTTCTTGTGCAATCGCGGCAAAAGAAAATCTTGAGATTAGGTGTTTATGCTGGCAGTAGCTGGGATGTACCCAGTGGGAAAGATTATCAATTTTTAGATAGTGTCATTAAACGGTTTGAAAAGGCTCATCCAAATGTTGATGTTCAATATGAGACTGGCATTTTAAAAGAAGATTATTCTTCGTGGCTGTCTAAAAAAATTGTTGAGGGAAAGCAACCAGATGTTTTTATGGTTCCTGAAAATGATTTTAATCTTTTAGCTTCAACAAAAACTTTAGCTAATTTAGATAGTTATATTAAAAAAGATTTGAAACCTTCGCTCTTTTATCATTCAGCCTATAATTCAGGTCAATTTGAAAGGAAACAATTTGCCCTTCCCTTTGAAAGCAATCCTGTTATGATGTGCATCAATAATGATCTCTTAAAAAAAGAGGGAATAGAGTTACCAAACTCTTCATGGACCTTAAACGATTTTTATAGTATTTGTAAAAAAGTTACCAAGGATACAGATGGTGATGGTGTTATTGATCAATATGGCAGTCTAGGTTATGGTTGGGAAGAGGCTTTAGCTGCCTATAATGTTAAGTTATTTAATGAAACTGGTACAGAGGCTTACTTTAACACCAAAAGAGTTCGTTCGGCTTTAGCATTAGTCACAAAATTAAAGAGCTTAAATGGTAATTATAATGTTACTCTTAAAGATTTTGATGAGGGTAAGGTTGCTTTTTATCCTATGACTCTAGCTCAATATCGTACTTATAAACCCTATCCTTATCATGTTGCAAAATACTCTTCCTTTTCGTGGTCTTGTGTTGAAATGCCTTCACAAAAACCAAATACGGCGAAGATACAAATTAATACATCTTTATATGCTATGTCGTCCAAAACTTCACAGTCTAAATTAGCTTGGGAGTTTCTTAAACTTTTATGTGCCAATAAAAAATCACAACAGCAATTATTTGAAGAATCACAAGGAGCATCTGTTTTAAAATCAGTAATGAACAGTCAAGCAAGTAAGAATCTTTTGCAAAATGATAGCTTTGGTTCAAAAGCTTTGACTGTTAATACCTTGGACAATATGATGCGAAAAGCGAAAACGACTCCTAAATTTAAATCTTATAATACTATTTATGAAAAAGCAGGCTATCTTATTACCAAATCGTTGGAAGGAAATACTGTAGAAAATGATTTATCTGATATTCAAAAAGAAATTGAAGAAGAATTAAAGTAG","9.80","11.79","49601","MIKKRLYQYKFHLLVLLVLLGALLTLFLVQSRQKKILRLGVYAGSSWDVPSGKDYQFLDSVIKRFEKAHPNVDVQYETGILKEDYSSWLSKKIVEGKQPDVFMVPENDFNLLASTKTLANLDSYIKKDLKPSLFYHSAYNSGQFERKQFALPFESNPVMMCINNDLLKKEGIELPNSSWTLNDFYSICKKVTKDTDGDGVIDQYGSLGYGWEEALAAYNVKLFNETGTEAYFNTKRVRSALALVTKLKSLNGNYNVTLKDFDEGKVAFYPMTLAQYRTYKPYPYHVAKYSSFSWSCVEMPSQKPNTAKIQINTSLYAMSSKTSQSKLAWEFLKLLCANKKSQQQLFEESQGASVLKSVMNSQASKNLLQNDSFGSKALTVNTLDNMMRKAKTTPKFKSYNTIYEKAGYLITKSLEGNTVENDLSDIQKEIEEELK","1838998","","sugar-binding periplasmic protein","Extracellular, Membrane","One very strong and several weak significant hits in gapped BLAST to sugar-binding periplasmic proteins; residues 32-434 are 46% similar to sugar-binding periplasmic protein of Clostridium acetobutylicum (gi|15894735); residues 54-245 are 31% similar to sugar ABC transporter, sugar-binding of Listeria monocytogenes (gi|16802227).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0034 (4e-08).","

InterPro
IPR006059
Family

Bacterial extracellular solute-binding protein, family 1
PF01547	$\"[15-342]T$	SBP_bac_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[47-363]T$	G3DSA:3.40.190.10
SSF53850	$\"[47-435]T$	SSF53850

","BeTs to 5 clades of COG1653COG name: Sugar-binding periplasmic proteins/domainsFunctional Class: GThe phylogenetic pattern of COG1653 is ---K--VCEBR------l---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 50-177 are 25% similar to a (COMPLETE PROTEOME SUGAR TRANSPORT) protein domain (PD001485) which is seen in YURO_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:34:27 2002","Mon Apr 15 08:27:27 2002","Tue Oct 15 11:37:21 2002","Fri Mar 1 15:51:08 2002","","Fri Mar 1 15:51:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1781 is paralogously related (blast p-value < 1e-3) to SMu1425, a predicted maltose/maltodextrin-binding protein.","Mon Apr 15 08:27:27 2002","","No significant hits to the NCBI PDB database.","SMU.1963c","","Residues 15 to 342 (E-value = 1.3e-13) place SMu1781 in the SBP_bac_1 family which is described as Bacterial extracellular solute-binding protein (PF01547)","Fri Mar 1 15:51:08 2002","24380307","","Zeng L, Wen ZT, Burne RA,A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177","","","","1","","","SMU.1963c","" "SMu1782","1840962","1840282","681","GTGATTAAAGTCTTGATTGCTGATGACCAAGAACTCATCAGAGAATCTTTAAAAATTGTTTTGTCATCCTATAAAGACATTGAAGTTGTTGATGCAGTCGATGACGGTTTTGCGGTTTTAGAGAGTATGAAAAAAGTTCAACCGGACCTTGTTTTGATGGATATCCGCATGCCTAAAATGGATGGCGTTTTATGTACCAAGGCCGTTAAGGAAAATTACCCTAATGTTAAAGTTATTATTTTAACAACCTTTGATGATGATGATTTTATTTTTAAAGCTCTTCAATATGGTGCTTCTGGTTACATTTTAAAGGGGATCTCTATGGAAGATTTATACCAGGCTATTGTGACAGTCAATAAAGGAAATGCCATGATTAATCCAGATGTTGCAACTAAGGTTGTTAAGCTGTTTTCACAAATGGCGCAGTCTAATTCTGCTATTCAAGTACAAGGAAATAGTGTCGAAAATATTTCAAAGGCTGAATGGAAAATTATTCAGCAAATTGGTTTTGGCTTATCAAATAAAGAAATTGCAGCTAAGCTCTTTTTGTCAGAAGGTACTATCCGTAATTACCTGTCGACCATTTTATCTAAATTGAATTTGCGTGATCGAACGCAATTAGCGATTTGGGCAGTCCAAACGGGTGTTACTACTAGACATTTTGGAGATGAAAATGATTAA","5.00","-3.80","25138","MIKVLIADDQELIRESLKIVLSSYKDIEVVDAVDDGFAVLESMKKVQPDLVLMDIRMPKMDGVLCTKAVKENYPNVKVIILTTFDDDDFIFKALQYGASGYILKGISMEDLYQAIVTVNKGNAMINPDVATKVVKLFSQMAQSNSAIQVQGNSVENISKAEWKIIQQIGFGLSNKEIAAKLFLSEGTIRNYLSTILSKLNLRDRTQLAIWAVQTGVTTRHFGDEND","1840298","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu1801 (comYD); SMu0451 (comF);SMu0452 (comFC); SMu0490 (comC);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).","two-component response regulator","Cytoplasm","Many significant hits in gapped BLAST to two-component response regulators; residues 1-216 are 62% similar to two-component system regulator of Clostridium acetobutylicum (gi|15894734); residues 1-217 are 36% similar to two-component regulator protein of Bacillus subtilis (gi|7443042).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0322 (6e-27).","

InterPro
IPR000792
Domain

Bacterial regulatory protein, LuxR
PD000307	$\"[157-208]T$	Q97MF8_CLOAB_Q97MF8;
PR00038	$\"[157-171]T$ $\"[171-187]T$ $\"[187-199]T$	HTHLUXR
PF00196	$\"[154-211]T$	GerE
SM00421	$\"[154-211]T$	HTH_LUXR
PS50043	$\"[150-215]T$	HTH_LUXR_2

InterPro
IPR001789
Domain

Response regulator receiver
PD000039	$\"[2-115]T$	Q8DS71_STRMU_Q8DS71;
PF00072	$\"[2-116]T$	Response_reg
SM00448	$\"[2-115]T$	REC
PS50110	$\"[3-119]T$	RESPONSE_REGULATORY

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[130-217]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[2-128]T$	no description
PTHR23283	$\"[3-119]T$	SENSOR HISTIDINE KINASE-RELATED
PTHR23283:SF41	$\"[3-119]T$	TWO COMPONENT SENSOR AND REGULATOR HISTIDINE KINASE BACTERIA

","BeTs to 4 clades of COG2197COG name: Response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domainFunctional Class: T,KThe phylogenetic pattern of COG2197 is -------CEBRh---------Number of proteins in this genome belonging to this COG is 4","***** IPB000673 (CheB methylesterase) with a combined E-value of 4.7e-20. IPB000673A 4-14 IPB000673B 21-74 IPB000673C 75-105***** IPB000792 (Bacterial regulatory protein, LuxR family) with a combined E-value of 1.4e-16. IPB000792 157-203***** IPB001789 (Response regulator receiver domain) with a combined E-value of 8.7e-13. IPB001789A 4-10 IPB001789B 49-62 IPB001789C 97-106***** IPB001867 (Transcriptional regulatory protein, C terminal) with a combined E-value of 1.5e-10. IPB001867A 49-62 IPB001867B 77-121","Residues 2-115 are 37% similar to a (SENSORY TRANSDUCTION PHOSPHORYLATION REGULATOR) protein domain (PD000039) which is seen in P94439_BACSU.Residues 157-213 are 49% similar to a (DNA-BINDING TRANSCRIPTION REGULATION REGULATOR) protein domain (PD000307) which is seen in P94439_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 14:57:46 2002","Fri Mar 1 15:40:13 2002","Tue Oct 15 11:36:23 2002","Fri Mar 1 15:32:00 2002","Tue Jan 8 12:07:51 2002","Tue Jan 8 12:07:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1782 is paralogously related (blast p-value < 1e-3) to SMu0441, SMu1406, SMu1379, SMu1653, SMu0918, SMu0841, SMu1748, SMu1032, SMu0947, SMu0601, and SMu0525, all predicted response regulators.","Mon Apr 15 08:51:35 2002","Tue Jan 8 12:07:51 2002","pdb|1A04|A Chain A, The Structure Of The NitrateNITRITE RESPON... 97 2e-021pdb|1DZ3|A Chain A, Domain-Swapping In The Sporulation Response... 63 3e-011pdb|1TMY| Chey From Thermotoga Maritima (Apo-I) >gi|2781153|p... 62 6e-011","SMU.1964c","","Residues 2 to 123 (E-value = 1.2e-35) place SMu1782 in the Response_reg family which is described as Response regulator receiver domain (PF00072)Residues 154 to 211 (E-value = 5.8e-17) place SMu1782 in the GerE family which is described as Bacterial regulatory proteins, luxR family (PF00196)","Tue Jan 8 12:07:51 2002","24380308","","Zeng L, Wen ZT, Burne RA,A novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177","Yamamoto,H., Uchiyama,S. and Sekiguchi,J. The Bacillus subtilis chromosome region near 78 degrees contains the genes encoding a new two-component system, three ABC transporters and a lipase. Gene 181 (1-2), 147-151 (1996) PubMed: 8973323.","","Fri Mar 1 15:40:13 2002","1","","","SMU.1964c","" "SMu1783","1842284","1840962","1323","ATGAATAGTTATAAGTATTTAAAATACAGTCAATATGCTAAGCAGGCTTTAATTTTTATTAATTTTTTGGCAGTTACTTATTATGTTTTTGTTTATCTTTTTGCTAGCAAATATATTGTGGCTAAAAATTTAAGTCATGTTCTTTTGGATAAACTAGATATTGTCCCTATAGCCCCTGAAAATATCTTTTTTACAACACTCTTCTTTTTTGCCATTTTTCTCATTGTCATGTTTTATAGAGAAAGTATTCTTAATAAAAAGGAAGAGATTAATGATTGGTTGATTGTTGCAGAAATTGTCTTAATGATTCTTACCTTTATTTCCTTGCAATTTTCTTACAATGGGCTGTTCCTCCTCGTTTTTGCAGATATTTTTTATAGTTATGCTAATTTTTATAATGTTAAGGAGCAAAAATATTGGCTTCTTTTCATCATTCTAGGCTTTAGTATGCTTTTGATCTCAAATTTCGATCTTTTATCTCTGGTGATGAGACTACCTTCTTTAGATGTTTACATTAGCTTTTTTCCTAGTGGCAGTCGTCTGATTGTTATGTTTATTAAAAACTTTCTTTACTCGCTCAATATCATTGTTTTTCTAATTTCTTTAGTGGCTTATATCATGTATTCAGTAGCTGAAAATCATAAGATAGAAGAAGAGCTGAGGATGGCTGCACGTGCTAATATTGAACTAAATGATTATGTTTCTTTGGCTGAGAAAATCGCTGAGGATAAAGAGCGTAAGAGGATTGCCAGAGAAATTCATGATACCTTGGGGCATGCTTTAACGGGTATTTCAGCAGGAATTGACGCAGTTACTGTGTTAGTTGATTTTGATCCTAATCATGCTAAGAGTCAACTAAAAAATGTGTCAGATGTTGTTAGAGAAGGTATTCAAGATGTTAGAAGGTCTTTAGAAAAAATGAGGCCAGGGGCCCTTGAAAAGGGAAGCCTTAAAGAGGCTTTATTAAAAATGATTGCAGATTATGAAAAATTATCCAAGCTACAGGTCAGTCTGCATTATGATTGGGATAACATTGATTTAGACATTACTAAGGAAGATATTATTTTCCGTGTTATTCAAGAGACTATTACCAATTCCCTTAGACATGGGCATGCCCGTCATGTCAGTATCGATATGCTCAATGAGGATTTCTATATTATTAAGATTAAGGACGATGGTATTGGCTGTGAGGATTTTAAATTGGGGTATGGTTTAACACAAATGCAAGAACGGTTAGCTATTATTGGAGGCTATGCGGACTTTGAAAGTGATGATGGTTTTCAAACAATGGTAAGAATACCTAAGAAAAAAGGAGAAGAATAG","5.70","-6.85","50969","MNSYKYLKYSQYAKQALIFINFLAVTYYVFVYLFASKYIVAKNLSHVLLDKLDIVPIAPENIFFTTLFFFAIFLIVMFYRESILNKKEEINDWLIVAEIVLMILTFISLQFSYNGLFLLVFADIFYSYANFYNVKEQKYWLLFIILGFSMLLISNFDLLSLVMRLPSLDVYISFFPSGSRLIVMFIKNFLYSLNIIVFLISLVAYIMYSVAENHKIEEELRMAARANIELNDYVSLAEKIAEDKERKRIAREIHDTLGHALTGISAGIDAVTVLVDFDPNHAKSQLKNVSDVVREGIQDVRRSLEKMRPGALEKGSLKEALLKMIADYEKLSKLQVSLHYDWDNIDLDITKEDIIFRVIQETITNSLRHGHARHVSIDMLNEDFYIIKIKDDGIGCEDFKLGYGLTQMQERLAIIGGYADFESDDGFQTMVRIPKKKGEE","1840978","There is poor similarity/conservation of the N-terminal end of this protein with respect to similar histidine kinases in other bacteria.","histidine kinase","Membrane, Cytoplasm","Several moderate and partial hits in gapped BLAST to Histidine kinase-like ATPases; residues 12-439 are 32% similar to Membrane associated histidine kinase-like ATPase of Clostridium acetobutylicum (gi|15894733); residues 217-427 are 32% similar to two-component sensor histidine kinase of Bacillus subtilis (gi|16077896).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0321 (2e-16).","

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[308-433]T$	ATP_bd_ATPase
PF02518	$\"[350-436]T$	HATPase_c
SM00387	$\"[350-437]T$	HATPase_c
SSF55874	$\"[317-438]T$	ATP_bd_ATPase

InterPro
IPR011712
Domain

Histidine kinase, dimerisation and phosphoacceptor region
PF07730	$\"[245-312]T$	HisKA_3

","BeTs to 6 clades of COG0642COG name: Sensory transduction histidine kinasesFunctional Class: TThe phylogenetic pattern of COG0642 is AMT-YQVCEBRHUJ--O-inXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 244-326 are 40% similar to a (KINASE SENSOR TWO-COMPONENT PROTEOME COMPLETE SENSORY) protein domain (PD002447) which is seen in Q55918_SYNY3.Residues 359-426 are 43% similar to a (KINASE COMPLETE PROTEOME HISTIDINE) protein domain (PD088883) which is seen in Q9F5X3_BACLI.Residues 335-433 are 33% similar to a (KINASE SENSOR COMPLETE PROTEOME SENSORY TRANSDUCTION) protein domain (PD005700) which is seen in Q9ZBS5_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 1 15:28:18 2002","Thu Oct 24 11:31:46 2002","Tue Oct 15 11:35:39 2002","Fri Mar 1 15:11:35 2002","","Tue Jan 8 12:08:33 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1783 is paralogously related (blast p-value < 1e-3) to SMu0440, and SMu1407,both predicted histidine kinases.","Mon Apr 15 08:53:36 2002","","No significant hits to the NCBI PDB database.","SMU.1965c","","Residues 350 to 436 (E-value = 6.7e-07) place SMu1783 in the HATPase_c family which is described as Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518)","Tue Jan 8 12:08:33 2002","24380309","","Zeng L, Wen ZT, Burne RAA novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177","Yamamoto,H., Uchiyama,S. and Sekiguchi,J. The Bacillus subtilis chromosome region near 78 degrees contains the genes encoding a new two-component system, three ABC transporters and a lipase. Gene 181 (1-2), 147-151 (1996) PubMed: 8973323.","","Fri Mar 1 15:44:06 2002","1","","","SMU.1965c","" "SMu1784","1843246","1842284","963","ATGAAAATACAGAGTTTAGTGAAGTCTCTAGCCTGCCTTTTTGTTGTGCTAATTATTTCAAGTCTGTTTTTTTATTATAAAGAGGAACCTGTTTTTCCAAGGCAAACTAAGATTGGTGCTACTTATATGACAATGAATAATGATTTTTATAAGTATCTCAATGCTGAAGTGGAAAAAAATGTTAATGAGCAACACGATTTACTTTATACGCGGGATCCGGCTCTTAGTATTAAAAAACAGGTTGAACAAATTCGGTTTTTTATTAAGGAGAGAGTTGATGTTATCATTATTAATCCAGTTGATGGTAATAGCAAACTCTTGATTAATAGTCTTAAAAGAGCTAGAAAGCAAGGTATTAAAGTTATTGCAGTAGATAGTCAGTTTAAAGATAATTCTGCTATTAACACGACCATTGTCTCAGATAATTATAAGGCGGGTGTACTGTGTGCTCAAGAAATGATACGAAAACAAAAAGGTGCTAAAATTCTTCTTTTAGAGCATCGTAATGCTTTATCTGCTACAAGTAGGATACAAGGCTTTCTTGATACCATTAAAACGCATAAGGACTATCAGGTTGTTGCACGAATTGATAGTTTAGGACAGACAGAAATTGCCATGCCTAAAGTAAAAAAACTTATTGAAAATGGTTTAACATTTGATACTGTCATGGCGCTCAATGATAGAGCAGCCATAGGTGCTTTAGCAGCAGTAAAAGGTGAAAAATTACCAACTAATCCTTATATTTATGGTATTGATGGTTCACCAGATATGAAAAATCTGCTTTCAGCCACTTCAGAAGTGCAAGCAACGGTAGCTCAATCACCTTATACTATGGGACAGGAAGTTACAAAGGCAAGTCTTAAATTATCTAAGAATCAGACTTATCCTAAGAGAATTGTTGTGCCCGTTGAATTAATAACAAAGAAAACAATCGGGAAGTATGATTTAACAGGGTGGCAGTGA","10.30","14.63","35901","MKIQSLVKSLACLFVVLIISSLFFYYKEEPVFPRQTKIGATYMTMNNDFYKYLNAEVEKNVNEQHDLLYTRDPALSIKKQVEQIRFFIKERVDVIIINPVDGNSKLLINSLKRARKQGIKVIAVDSQFKDNSAINTTIVSDNYKAGVLCAQEMIRKQKGAKILLLEHRNALSATSRIQGFLDTIKTHKDYQVVARIDSLGQTEIAMPKVKKLIENGLTFDTVMALNDRAAIGALAAVKGEKLPTNPYIYGIDGSPDMKNLLSATSEVQATVAQSPYTMGQEVTKASLKLSKNQTYPKRIVVPVELITKKTIGKYDLTGWQ","1842300","From GenBank (gi:6174949): In Bacillus subtilis, this protein is involved in the high-affinity d-ribose membrane transport system. It is attached to the membrane by a lipid anchor and belongs to the bacterial extracellular solute-binding receptor family 2.","ABC transport ribose-binding protein, periplasmic","Membrane, Cytoplasm","Several strong matches in gapped BLAST to sugar binding proteins; e.g. residues 37-320 are 41% similar to Ribose ABC transporter (ribose-binding periplasmic component) of Clostridium acetobutylicum (gi15024397); residues 38-319 are 30% similar to periplasmic ribose-binding protein of ABC transport system of Escherichia coli (gi15804680). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0114 (2e-28).","

InterPro
IPR001761
Domain

Periplasmic binding protein/LacI transcriptional regulator
PF00532	$\"[35-309]T$	Peripla_BP_1

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.2300	$\"[140-285]T$	G3DSA:3.40.50.2300
SSF53822	$\"[34-314]T$	SSF53822

","BeTs to 3 clades of COG1879COG name: Periplasmic sugar-binding proteinsFunctional Class: GThe phylogenetic pattern of COG1879 is ------V-Eb-H-----l---Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 119-238 are 27% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REPRESSOR) protein domain (PD000591) which is seen in Q9X6A9_YERPE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 15:56:08 2002","Tue Apr 3 14:36:07 2007","Thu Sep 28 09:12:10 2006","Wed Jan 16 15:53:51 2002","","Wed Jan 16 15:53:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1784 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 15:56:08 2002","Thu Sep 28 09:12:10 2006","pdb1DRK D-Ribose-Binding Protein Mutant With Ile 132 Repla... 80 3e-016pdb1DBP D-Ribose-Binding Protein Mutant With Gly 72 Replac... 78 1e-015pdb2DRI D-Ribose-Binding Protein Complexed With Beta-D-Rib... 78 1e-015","SMU.1966c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 15:53:51 2002","24380310","","Zeng L, Wen ZT, Burne RAA novel signal transduction system and feedback loop regulate fructan hydrolase gene expression in Streptococcus mutans.Mol Microbiol. 2006 Oct;62(1):187-200.PMID: 16987177","Woodson,K. and Devine,K.M. Analysis of a ribose transport operon from Bacillus subtilis . Microbiology 140 (Pt 8): 1829-1838(1994) [PubMed: 7921236].","Tue Apr 3 14:36:07 2007","Wed Jan 16 15:56:08 2002","1","","","SMU.1966c","" "SMu1785","1844057","1843662","396","ATGTATAATAAAGTTATTTTGATTGGTCGTTTAGTTGCGACACCTGAAATGGTAAAAACACCAAAGGATAAGTCTGTTACGCGCGTGACACTGGCTGTCAATCGGCGATTTAAAAGTCAAGATGGGGAAAAGCAGGCTGATTTTGTCAATGTTGTTCTTTGGGGCAGATTGGCAGAAACAATAGCTTCCTATGGTAGTAAGGGAAGTCTCATCTCTCTTGATGGAGAATTGCGTACCCGTAAATATGAAAAAGATGGCGTCACTCATTTTGTGACTGAAGTTTTGGGACACTCCTTTCAATTACTGGAAAGTCGTGCTCAACGTGCTATGCGTGAAAATAATTCTGAAAATGATTTGGCCGATTTGGTTCTAGAAGAGGAGGAACTCCCTTTTTAA","6.60","-0.52","14826","MYNKVILIGRLVATPEMVKTPKDKSVTRVTLAVNRRFKSQDGEKQADFVNVVLWGRLAETIASYGSKGSLISLDGELRTRKYEKDGVTHFVTEVLGHSFQLLESRAQRAMRENNSENDLADLVLEEEELPF","1843678","From GenBank (gi:586039): In Bacillus subtilis, this protein is essential for replication of the chromosome. It is also involved in DNA recombination and repair, and it belongs to the ssb family. From GenBank (gi:15459403): Also known as Competence induced loci A, CilA.","single-stranded DNA-binding protein","Cytoplasm","Numerous moderate matches in gapped BLAST to single-strand DNA binding protein; residues 1-115 are 73% similar to Single-stranded DNA-binding protein of Streptococcus pneumoniae (gi15903766); residues 1-108 are 48% similar to single-strand binding protein of Streptococcus pneumoniae (gi14973030). See Spy0120.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0180 (1e-51).","

InterPro
IPR000424
Family

Single-strand binding protein/Primosomal replication protein n
PF00436	$\"[2-102]T$	SSB
PS50935	$\"[1-103]T$	SSB

InterPro
IPR011344
Family

Single-strand binding protein
PTHR10302	$\"[34-131]T$	Single_strand_bd
TIGR00621	$\"[1-131]T$	ssb

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[2-117]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
PIRSF002070	$\"[2-130]T$	SSB
SSF50249	$\"[1-131]T$	Nucleic_acid_OB

","BeTs to 11 clades of COG0629COG name: Single-stranded DNA-binding proteinFunctional Class: LThe phylogenetic pattern of COG0629 is ----yqvCeBRhujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000424 (Single-strand binding protein family) with a combined E-value of 2e-21. IPB000424A 2-40 IPB000424B 63-85 IPB000424C 125-131","Residues 3-59 are 59% similar to a (DNA-BINDING SINGLE-STRAND REPLICATION) protein domain (PD186103) which is seen in Q9CIG8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 15:21:40 2002","Wed Jan 16 15:21:40 2002","Wed Feb 22 10:00:53 2006","Wed Jan 16 15:21:40 2002","Wed Jan 16 15:21:40 2002","Wed Jan 16 15:21:40 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1785 is paralogously related (blast p-value < 1e-3) to SMu1693, a predicted single-stranded DNA-binding protein.","Mon Apr 15 08:54:45 2002","Wed Feb 22 10:00:53 2006","pdb1EYGA Chain A, Crystal Structure Of Chymotryptic Fragment ... 68 4e-013pdb1QVCA Chain A, Crystal Structure Analysis Of Single Strand... 68 4e-013pdb1KAWA Chain A, Structure Of Single Stranded Dna Binding Pr... 68 4e-013","SMU.1967c","","Residues 2 to 103 (E-value = 7.7e-29) place SMu1785 in the SSB family which is described as Single-strand binding protein family (PF00436)","Wed Jan 16 15:21:40 2002","","","","","","","1","","","SMU.1967c","752" "SMu1786","1844500","1844144","357","ATGGATAAACTTGCATTTTTAGAAATGTATCTTGATTTATATAGGAATCATTTTACAGTTTTGGAGGCCATGAAAGCAGAAAATTCGGATATTGTGGTGTTAGATATTAGAAATGCTCCATCTCAGATTAAGAAAGAGCAAATTAAAGGAGCAAAGGTTATGCCAGCTAAGGACTTAGCTAATCATTTGACAGAGCTTGATAAAAATAAAACCTATGTTGTCTACGATTGGAATGGCGGCAGTGTTTTAGGTAAGCACGCCTTATTTATTCTTTTGAAGGCAGGATTTAAAGCATATGAATTAGCAGGAGCTTTTGAAGGATGGAAAGGCATGCATTTGCCAACAGAAAAATGCTGA","8.40","1.90","13343","MDKLAFLEMYLDLYRNHFTVLEAMKAENSDIVVLDIRNAPSQIKKEQIKGAKVMPAKDLANHLTELDKNKTYVVYDWNGGSVLGKHALFILLKAGFKAYELAGAFEGWKGMHLPTEKC","1844160","","conserved hypothetical protein","Cytoplasm","Few weak matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-117 are 66% similar to hypothetical protein of Streptococcus criceti (gi|15383629); residues 4-107 are 28% similar to hypothetical protein 120 of Bacillus licheniformis (gi|628983). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2042 (4e-07).","

InterPro
IPR001763
Domain

Rhodanese-like
SM00450	$\"[18-114]T$	RHOD
PS50206	$\"[27-117]T$	RHODANESE_3

noIPR
unintegrated

unintegrated
G3DSA:3.40.250.10	$\"[17-117]T$	G3DSA:3.40.250.10
SSF52821	$\"[6-117]T$	SSF52821

","BeTs to 6 clades of COG0607COG name: Rhodanese-related sulfurtransferasesFunctional Class: PThe phylogenetic pattern of COG0607 is amT-YQ-CEBRHuj--o---xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 08:55:41 2002","Wed Jan 16 15:07:05 2002","Wed Jan 16 15:07:05 2002","Wed Jan 16 15:07:05 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1786 is paralogously related (blast p-value < 1e-3) to SMu0494, also a predicted conserved hypothetical protein.","Mon Apr 15 08:55:41 2002","","No significant hits to the NCBI PDB database.","SMU.1968c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 15:07:05 2002","24380312","","","","","","1","","","SMU.1968c","" "SMu1787","1844931","1844500","432","GTGATTATATTGAAATTAGAAGATTCTTGGGGATTTCAGATTAGTAAGATTGCTCAAGAGATGGACAGTCAATTTTCGAAGAAGCTAACAAAATATGATATCGGTTCCAGAGAATACGGTATTTTGTTGACAATTCATCAATATGCACTGTTAACACAGCTTAAGATTGGTGAACTGAACAAGGTTGATCGTACGACAATTGGGCAGCTTGTTGATTTATTAGAAAGAAAAGACTTTGTGGCGAGACAAAAGAATCCAAAAGATAGACGACAAAATTTACTAGTTTTAACTAAAACAGGGCGATCTTTGGCTGAAGAAATGTGGCAGGAAATGAAAGAGATAGAAAAAGACGTTCTTAAGCATTTGTCTGCTAAACAAAAAGAAACGCTTTTAACGATGGTAAAAGCAATTAGGAAAGGAGAGTTGAACTGA","10.30","6.48","16626","MIILKLEDSWGFQISKIAQEMDSQFSKKLTKYDIGSREYGILLTIHQYALLTQLKIGELNKVDRTTIGQLVDLLERKDFVARQKNPKDRRQNLLVLTKTGRSLAEEMWQEMKEIEKDVLKHLSAKQKETLLTMVKAIRKGELN","1844516","","probable transcriptional regulator","Cytoplasm","Few weak matches in gapped BLAST to transcriptional regulators; e.g. residues 21-139 are 46% similar to transcriptional regulator of Streptococcus criceti (gi|15383628); residues 3-137 are 27% similar to transcriptional regulator of Mesorhizobium loti (gi|13476856). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1910 (6e-06).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PR00598	$\"[51-67]T$ $\"[68-83]T$ $\"[87-103]T$ $\"[117-137]T$	HTHMARR
PF01047	$\"[34-103]T$	MarR
SM00347	$\"[27-127]T$	HTH_MARR
PS50995	$\"[7-139]T$	HTH_MARR_2
PS01117	$\"[66-100]T$	HTH_MARR_1

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[34-107]T$	no description

","BeTs to 5 clades of COG1846COG name: Transcriptional regulators, MarR/EmrR familyFunctional Class: KThe phylogenetic pattern of COG1846 is amtk--V-EBR----------Number of proteins in this genome belonging to this COG is 9","***** IPB000835 (Bacterial regulatory protein, MarR family) with a combined E-value of 8.5e-11. IPB000835 67-100","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 08:58:20 2002","Wed Jan 16 14:52:57 2002","Tue Oct 15 11:29:52 2002","Wed Jan 16 14:52:57 2002","Wed Jan 16 14:52:57 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1787 is paralogously related (blast p-value < 1e-3) to SMu0935, SMu0400, SMu0574, SMu1004, and SMu0835, all predicted transcriptional regulators.","Mon Apr 15 08:58:20 2002","","No significant hits to the NCBI PDB database.","SMU.1969c","","Residues 34 to 137 (E-value = 5.5e-17) place SMu1787 in the MarR family which is described as MarR family (PF01047)","Wed Jan 16 14:52:57 2002","24380313","","","","","","1","","","SMU.1969c","" "SMu1788","1845646","1845020","627","ATGATTTTTACATATAATAAAGAACACGTTGGAGATGTCCTTATGGTTATTGTTAAAGATAGTAAGGGCGCAAAGTTAAACTGTGAACGCAAGGGTAAGGTGACTCGTATTTTTCTTGAAAAAAATAAGGAGACAGTGGCTTGGAATATTTTTGCGGTATCAAATTTGCTTGATCTTAATGGCAATGGACAGGTATTTTTGACAGATGAAGAGCTGGCGGTTTTAAATGCTGAACTTGCCAAAGAAGGTTTTGAAGAAAAATTAGAAAATAATGCCGCAGCTAAGTTTGTTGTTGGTGAAATTGTAGAAATGGTTGCTCATCCAGATAGTGATCATCTTAATATTTGTCAAGTTAAGATTGCTGAGGACAAGACTGTCCAAATTGTTGCTGGTGCACCAAATGCCAGAGTAGGATTGAAAACCATTGTTGCTCTGCCAGGTGCCATGATGCCAAGCGGTGGCCTCATTTTTCCAGGCAACTTACGTGGCGAAAAGAGCTTTGGCATGTTGTGTTCTCCTCGCGAGTTAGCTTTGCCTAAAGCTCCTCAAAAGCGTGGAATTATTGAATTAAGTACAGATGCTGTTATAGGCCAAGCTTTTGATGCTGGGAAACATTGGAAAGGGTGA","6.90","-0.17","22524","MIFTYNKEHVGDVLMVIVKDSKGAKLNCERKGKVTRIFLEKNKETVAWNIFAVSNLLDLNGNGQVFLTDEELAVLNAELAKEGFEEKLENNAAAKFVVGEIVEMVAHPDSDHLNICQVKIAEDKTVQIVAGAPNARVGLKTIVALPGAMMPSGGLIFPGNLRGEKSFGMLCSPRELALPKAPQKRGIIELSTDAVIGQAFDAGKHWKG","1845036","For other 'phe' genes see SMu0713 (pheA); SMu1178 (pheA); SMu1367 (pheT); SMu1372 (pheT) and SMu1374 (pheS).For phenylalanyl-tRNA synthetase (beta subunit) see SMu1367.For phenylalanyl-tRNA synthetase (beta subunit) see SMu1372. For phenylalanyl-tRNA synthetase (alpha subunit) see SMu1374. From GenBank (gi:12585228): In Bacillus halodurans, this protein catalyzes the reaction: tRNA(phe) = AMP + pyrophosphate + l-phenylalanyl-tRNA(phe). It is a tetramer of two alpha and two beta chains. This cytoplasmic protein belongs to the phenylalanyl-tRNA synthetase beta chain family, subfamily 1. ","phenylalanyl-tRNA synthetase beta subunit","Cytoplasm","Many strong matches in gapped BLAST to conserved hypothetical proteins and phenylalanyl-tRNA synthetase, beta subunit; e.g. residues 1-206 are 75% similar to conserved hypothetical protein of Streptococcus pneumoniae (gi15901735); residues 5-200 are 43% similar to phenylalanyl-tRNA synthetase, beta subunit of Bacillus subtilis (gi16080034).See Spy0119. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0178 (1e-81).","

InterPro
IPR002547
Domain

t-RNA-binding region
PF01588	$\"[96-199]T$	tRNA_bind
PS50886	$\"[90-201]T$	TRBD

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[89-207]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
PTHR10947	$\"[30-179]T$	PTHR10947
SSF50249	$\"[90-205]T$	Nucleic_acid_OB

","BeTs to 12 clades of COG0073COG name: EMAP domainFunctional Class: RThe phylogenetic pattern of COG0073 is AmTKyQVcEBrHUJGPolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002547 (Putative tRNA binding domain) with a combined E-value of 8.2e-10. IPB002547A 107-121 IPB002547B 155-172","Residues 97-172 are 69% similar to a (SYNTHETASE BETA CHAIN LIGASE) protein domain (PD009777) which is seen in Q9CIH0_LACLA.Residues 9-96 are 52% similar to a (PROTEOME COMPLETE SYNTHETASE BETA) protein domain (PD072011) which is seen in Q9CIH0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 22 09:58:20 2006","Wed Feb 22 09:58:20 2006","Wed Feb 22 09:58:20 2006","Wed Jan 16 14:46:30 2002","Wed Jan 16 14:46:30 2002","Wed Jan 16 14:46:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1788 is paralogously related (blast p-value < 1e-3) to SMu1372, a predicted phenylalanyl-tRNA synthetase (beta subunit).","Mon Apr 15 08:59:16 2002","","No significant hits to the NCBI PDB database.","SMU.1970c","","Residues 96 to 199 (E-value = 5.5e-22) place SMu1788 in the tRNA_bind family which is described as Putative tRNA binding domain (PF01588)","Wed Jan 16 14:46:30 2002","24380314","","","Mechulam,Y., Fayat,G. and Blanquet,S. Sequence of the Escherichia coli pheST operon and identification of the himA gene. J. Bacteriol. 163 (2): 787-791 (1985) [PubMed: ].","","Wed Jan 16 14:46:30 2002","1","","","SMU.1970c","626" "SMu1789","1845972","1845643","330","GTGATTGTTCCAAAAACGTATGAAGAATTGGCTGTTTATTTTGAAAAGCCTGACAAGCTTGTCCTTTTCTTTACAGCAGATTGGTGCTCTGATTGTCAATTTATCTACCCAGCCATGCCTAAAATTGAGCTGGCAAATCCAGACTTTCTTTTTCTTCGTGTAGACCGTGATAATTTCATGGAAATCGCGCAGCGCTGGCATATTTTTGGTATTCCAAGTTTTGTTGTCGTAGAAAATGGTAAAGAAATTGGCCGTTTAGTCAGTAAATCACGTAAAACACAAGCAGAGATTAACAGCTTTTTGGCTGAATTAACAGAGGAGAAATTATGA","4.80","-3.86","12719","MIVPKTYEELAVYFEKPDKLVLFFTADWCSDCQFIYPAMPKIELANPDFLFLRVDRDNFMEIAQRWHIFGIPSFVVVENGKEIGRLVSKSRKTQAEINSFLAELTEEKL","1845659","For other 'trx' genes see SMu0792 (trxB); SMu0420 (trxB) and SMu1699 (trxA).From GenBank (gi:267124): This protein was weakly similar to an H-type thioredoxin of Nicotiana tabacum. The N.tabacum protein participates in various redox reactions through the reversible oxidation of the active center dithiol, to a disulfide. The H form is known to activate a number of cytosolic enzymes. This cytoplasmic protein belongs to the thioredoxin family - plant H-type. ","thioredoxin family protein","Cytoplasm","Many moderate matches in gapped BLAST to thioredoxin H1; e.g. residues 1-102 are 57% similar to thioredoxin H-type of Lactococcus lactis (gi15672371); residues 1-104 are 54% similar to thioredoxin of Streptococcus pneumoniae (gi15901736).See Spy0118. The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0177 (3e-39).","

InterPro
IPR006662
Domain

Thioredoxin-related
PR00421	$\"[20-28]T$ $\"[28-37]T$ $\"[67-78]T$	THIOREDOXIN

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[1-96]T$	no description

InterPro
IPR013766
Domain

Thioredoxin domain
PF00085	$\"[1-104]T$	Thioredoxin

InterPro
IPR015467
Domain

Thioredoxin family
PTHR10438	$\"[18-101]T$	THIOREDOXIN-RELATED

noIPR
unintegrated

unintegrated
PTHR10438:SF4	$\"[18-101]T$	THIOREDOXIN-RELATED

","BeTs to 13 clades of COG0526COG name: Thiol-disulfide isomerase and thioredoxinsFunctional Class: O,CThe phylogenetic pattern of COG0526 is AMTkYQVCEBRHUJgpoLINXNumber of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 8-102 are 60% similar to a (PROTEOME THIOREDOXIN COMPLETE H-TYPE) protein domain (PD248887) which is seen in Q9CIH1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 09:31:03 2006","Thu Sep 7 09:31:03 2006","Wed Feb 22 09:57:25 2006","Wed Jan 16 14:36:05 2002","","Wed Jan 16 14:36:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1789 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Apr 8 09:22:54 2002","","No significant hits to the NCBI PDB database.","SMU.1971c","","Residues 1 to 106 (E-value = 8.5e-06) place SMu1789 in the Thioredoxin family which is described as Thioredoxin (PF00085)","Wed Jan 16 14:36:05 2002","24380315","","","","","","1","","","SMU.1971c","887" "SMu1790","1846258","1845950","309","ATGGAAAGTAAAAACTTCAAACTTGCTTCAAGTGCTTGTCTTATAGGAATAGGCGGAGCAGTTTTGCTTGGAACGGTTGTAAAAAAACAATTCGAAGAAAGAAAGCGTGAACGTATTAAGGCAGAGCTTCGCCAGTTTTTTAATCAGTTGGGTGAGATTGCTGTCCTCTACGTCAATGAATTTGAATCTGACAAAGATACGATACGAGGTGGTCTTGTCATGAATGATGAGACTATCTATCTTTTTACTTATGAGAATGGTCAGATAAGCTATGAGGAGGATAAACGTGATTGTTCCAAAAACGTATGA","5.10","-2.10","11661","MESKNFKLASSACLIGIGGAVLLGTVVKKQFEERKRERIKAELRQFFNQLGEIAVLYVNEFESDKDTIRGGLVMNDETIYLFTYENGQISYEEDKRDCSKNV","1845966","","conserved hypothetical protein","Cytoplasm","Two weak matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 7-95 are 41% similar to hypothetical protein of Streptococcus pyogenes (gi15674337).See Spy0117.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0176 (3e-15).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:54:06 2002","Wed Jan 16 14:29:01 2002","Wed Feb 22 09:54:13 2006","Wed Jan 16 14:29:01 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1790 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:54:06 2002","","No significant hits to the NCBI PDB database.","SMU.1972c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 14:29:01 2002","24380316","","","","","","1","","","SMU.1972c","1027" "SMu1791","1846318","1847385","1068","ATGACGGAATTATTTGACAAAATCAAAGAAATCACCGAACTTGATGGTATTGCCGGTTATGAGCACAAGATCCGTGACTTTTTTCGCCAAAAAATGACGCCTTTCGTTGATGAAGTTGAAACGGACGGTCTTGGTGGCCTTTTTGGCATCAAACATAGTAAGTTGGAAAGGGCTCCTCGTGTCATGGTCGCTGCTCACATGGATGAAGTTGGTTTTATGGTCAGCGATATTAAAGAAGATGGCACTTTGCGCGCGGTGGCTATCGGTGGCTGGAATCCTCTGGTTATTAGTTCACAACGCTTCACCCTTTATACACGCACTGAACAGGCGATTCCTGTTATTTCAGGTTCTGTCCCACCACATTTTCTACGTGGTAATAACGGCGGAGCTTCTTTACCCAAGGTCGAAGATATTGTTTTTGATGGCGGTTTTGCTGATAAAACAGAAGCTGAAAGCTTTGGCATAACCCCAGGTGATATCATTATTCCTAAATCAGAAGCTATTCTGACGGCTAATCAAAAGAATGTCATTTCCAAAGCTTGGGATAATCGTTACGGTGTTCTCATGGTTACAGAACTTCTTCAAAGCCTAAAAAATGAACAGCTAGACAATACCCTCATTGCTGGTGCTAATGTTCAAGAAGAAGTTGGTCTTCGTGGTGCTCAGGTTTCAACAACCAAATTCAAGCCAGATATTTTTCTGGCAGTTGACTGCTCACCTGCTGGTGATGTCTATGACAATCAAGGTAAAATTGGTGAGGGCACTCTCATTCGCTTTTACGATCCGGGTCATGTCATGCTTAAAGACATGCGTGACTTTTTGTTGACTACTGCCCAAGATGCTGGTGTCAAATACCAATACTATTGTGCTAAAGGGGGTACAGATGCTGGTGCTGCTCACCTCAAAAATAGCGGAATTCCTTCAACAACAATCGGCGTTTGTGCTCGTTATATTCACTCTCACCAAACACTCTATGCAATGGATGATTTCTTACAGGCTCAAGCTTTTCTGCAAACTATTGTGAAAAAACTTAATCGCTCTACAGTTGATTTAATCAAAAACTATTAG","5.70","-6.20","38992","MTELFDKIKEITELDGIAGYEHKIRDFFRQKMTPFVDEVETDGLGGLFGIKHSKLERAPRVMVAAHMDEVGFMVSDIKEDGTLRAVAIGGWNPLVISSQRFTLYTRTEQAIPVISGSVPPHFLRGNNGGASLPKVEDIVFDGGFADKTEAESFGITPGDIIIPKSEAILTANQKNVISKAWDNRYGVLMVTELLQSLKNEQLDNTLIAGANVQEEVGLRGAQVSTTKFKPDIFLAVDCSPAGDVYDNQGKIGEGTLIRFYDPGHVMLKDMRDFLLTTAQDAGVKYQYYCAKGGTDAGAAHLKNSGIPSTTIGVCARYIHSHQTLYAMDDFLQAQAFLQTIVKKLNRSTVDLIKNY","1847395","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1850 (pepO); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). From GenBank (gi:6093667): In Lactococcus lactis, the catalytic acitivity of this protein is the release of an N-terminal glutamate (and to a lesser extent aspartate) from a peptide. It belongs to peptidase family M42.","glutamyl aminopeptidase","Cytoplasm, Extracellular","Many strong matches in gapped BLAST to glutamyl-aminopeptidases; e.g. residues 1-355 are 80% similar to glutamyl-aminopeptidase of Streptococcus pyogenes (gi15674335); residues 1-355 are 73% similar to- glutamyl-aminopeptidase of Streptococcus pneumoniae (gi15901693). The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0174 (1e-173).","

InterPro
IPR008007
Family

Peptidase M42
PIRSF001123	$\"[4-355]T$	PepA_GA
PF05343	$\"[45-336]T$	Peptidase_M42

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.10	$\"[3-352]T$	G3DSA:3.40.630.10
SSF101821	$\"[71-162]T$	SSF101821
SSF53187	$\"[1-352]T$	SSF53187

","BeTs to 7 clades of COG1363COG name: Cellulase M and related proteinsFunctional Class: GThe phylogenetic pattern of COG1363 is amtK--V-EB-----------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 300-352 are 39% similar to a (PROTEOME COMPLETE ENDO-14-BETA-GLUCANASE) protein domain (PD412041) which is seen in P94521_BACSU.Residues 70-299 are 64% similar to a (COMPLETE PROTEOME AMINOPEPTIDASE) protein domain (PD004380) which is seen in PEPA_LACLC.Residues 8-69 are 46% similar to a (AMINOPEPTIDASE PROTEOME COMPLETE LONG) protein domain (PD232445) which is seen in O59485_PYRHO.Residues 300-355 are 66% similar to a (AMINOPEPTIDASE PROTEOME COMPLETE GLUTAMYL) protein domain (PD406308) which is seen in PEPA_LACLC.Residues 3-69 are 52% similar to a (AMINOPEPTIDASE PROTEOME GLUTAMYL) protein domain (PD236185) which is seen in PEPA_LACLC.Residues 9-69 are 47% similar to a (PROTEOME COMPLETE ENDO-14-BETA-GLUCANASE) protein domain (PD344738) which is seen in Q9K7V2_BACHD.Residues 226-344 are 31% similar to a (AMINOPEPTIDASE PROTEOME DEBLOCKING 339AA) protein domain (PD396438) which is seen in Q9YCC1_AERPE.Residues 8-69 are 38% similar to a (PROTEOME COMPLETE AMINOPEPTIDASE FRV) protein domain (PD005405) which is seen in O26537_METTH.Residues 8-69 are 38% similar to a (M ENDOGLUCANASE PROTEOME COMPLETE) protein domain (PD121337) which is seen in GUNM_CLOTM.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 18:10:16 2006","Tue Sep 5 18:10:16 2006","Tue Feb 21 10:24:26 2006","Wed Jan 16 14:25:58 2002","","Wed Jan 16 14:25:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1791 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 11:09:57 2002","","No significant hits to the NCBI PDB database.","SMU.1973","","Residues 45 to 336 (E-value = 4.2e-135) place SMu1791 in the Peptidase_M42 family which is described as M42 glutamyl aminopeptidase (PF05343)","Wed Jan 16 14:25:58 2002","24380317","","","l'Anson,K.J., Movahedi,S., Griffin,H.G., Gasson,M.J. andMulholland,F. A non-essential glutamyl aminopeptidase is required for optimal growth of Lactococcus lactis MG1363 in milk. Microbiology 141 (Pt 11): 2873-2881 (1995) [PubMed: 8535515].","","Tue Sep 5 18:10:16 2006","1","","","SMU.1973","245" "SMu1792","1847441","1848211","771","ATGAAAATTGGATTTATTGGTGTTGGTAAAATGGCCAGCGCTATTATTACTGGACTCAAAAAAACCGATTTTGAATTAATCATATCAGATAGCAGTTTGAAAGCCGGTCAAGACAAGGCAGAAGCACTTGGAGTTGCTGTTGCTCAATCTCATCAAGAATTGGTTGACGAGGTTGATTTACTTGTATTGGGTGTTAAACCACAAGTTCTTGCTTCTGTTTTGAATCCTTTAATATTAACAAAACCGATTTTATCCATGGCAGCCGGTACTTCATTAGAATATCTGGATAAATTAAGTCAGGCTGATTTACCGATCATCCGCATTATGCCTAATCTTAATGCTAAGATTCTTCAAAGTAGCACTGCTATCTGCCGAAATGATAAAGTTTCTGATCAGCTTTTTGCAATTGCCAAACAGATTACGGACTCATTTGGAACAACTTTTGAAATCGCTGAAAAAGATTTTGATACTTTCACCGCACTTGCAGGGTCCAGTCCTGCTTATATTGCACTCTTTATTGAAGCTATGTCAAAAGCAGGATTGAAACACGGATTTCCCAAAGATTTAGCTTTTAAGATTGTCAGTCAAACTGTTCTAGCAACTACAAGCAATCTCATCCAAGGGCAAGAGAAGCCAAACGATCTTATTGATAAGGTATCCAGTCCCGGTGGGACAACTATCGCTGGACTTCTTGATCTAGAGAAAACCGGCTTTACAGCCAGTACCATTTCAGCCATTGATGCGACTATTGACAAATCAAAAAACATGTAA","5.20","-3.57","27087","MKIGFIGVGKMASAIITGLKKTDFELIISDSSLKAGQDKAEALGVAVAQSHQELVDEVDLLVLGVKPQVLASVLNPLILTKPILSMAAGTSLEYLDKLSQADLPIIRIMPNLNAKILQSSTAICRNDKVSDQLFAIAKQITDSFGTTFEIAEKDFDTFTALAGSSPAYIALFIEAMSKAGLKHGFPKDLAFKIVSQTVLATTSNLIQGQEKPNDLIDKVSSPGGTTIAGLLDLEKTGFTASTISAIDATIDKSKNM","1848221","For other 'pro' genes see SMu1003 (proV); SMu0407 (proB);SMu0408 (proA) and SMu1623 (proS) . From GenBank (gi:6225883): In Aquifex aeolicus, this protein catalyzes the reaction: L-proline + NAD(P)(+) = 1-pyrroline-5-carbosylate + NAD(P)H. This is the third and terminal step in proline biosynthesis. It belongs to the pyrroline-5-carbosylate reductase family.","pyrroline-5-carboxylate reductase","Cytoplasm","Many strong matches in gapped BLAST to pyrroline carboxylate reductase; e.g. residues 1-256 are 58% similar to pyrroline carboxylate reductase of Streptococcus pyogenes (gi15674334); residues 3-256 are 50% similar to pyrroline carboxylate reductase of Lactococcus lactis (gi12724918).See Spy0112.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0173 (8e-86).","

InterPro
IPR000304
Family

Delta 1-pyrroline-5-carboxylate reductase
PIRSF000193	$\"[1-255]T$	Pyrrol-5-carb_rd
PTHR11645	$\"[1-256]T$	P5CR
TIGR00112	$\"[3-256]T$	proC
PS00521	$\"[212-234]T$	P5CR

InterPro
IPR004455
Family

NADP oxidoreductase, coenzyme F420-dependent
PF03807	$\"[2-241]T$	F420_oxidored

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[1-67]T$	G3DSA:3.40.50.720
SSF51735	$\"[1-171]T$	SSF51735

","BeTs to 10 clades of COG0345COG name: Pyrroline-5-carboxylate reductaseFunctional Class: EThe phylogenetic pattern of COG0345 is --t-yqvceBrhuj---l---Number of proteins in this genome belonging to this COG is 1","***** IPB000304 (Delta 1-pyrroline-5-carboxylate reductase) with a combined E-value of 4.3e-49. IPB000304A 3-18 IPB000304B 57-67 IPB000304C 105-114 IPB000304D 152-187 IPB000304E 211-239","Residues 3-52 are 54% similar to a (PROTEOME PYRROLINE-5-CARBOXYLATE COMPLETE) protein domain (PD386278) which is seen in Q9CEF7_LACLA.Residues 66-256 are 52% similar to a (REDUCTASE PYRROLINE-5-CARBOXYLATE) protein domain (PD002555) which is seen in Q9CEF7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 22 11:57:20 2006","Tue Aug 22 11:57:20 2006","Tue Feb 21 10:20:59 2006","Wed Jan 16 14:12:40 2002","Wed Jan 16 13:57:21 2002","Wed Jan 16 13:57:21 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1792 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 14:12:40 2002","","No significant hits to the NCBI PDB database.","SMU.1974","","Residues 1 to 241 (E-value = 1.8e-69) place SMu1792 in the P5CR family which is described as Delta 1-pyrroline-5-carboxylate reductase (PF01089)","Wed Jan 16 13:57:21 2002","24380318","","","Williamson,C.L. and Slocum,R.D. Molecular cloning and evidence for osmoregulation of the delta 1-pyrroline-5-carboxylate reductase (proC) gene in pea (Pisumsativum L.). Plant physiology. 100, 1464-1470 (1992) [PubMed: 11537868].","","Tue Feb 21 10:20:59 2006","1","","","SMU.1974","516" "SMu1793","1848958","1848296","663","ATGAAAACAATTTTAAAGAAAACGGCAGCAGTTATTGCTATTGTTGGTTTGTTTATTGTTAGTCAACTGCCAAGTATTGTGATGGCACTTTGGCAGAGAAATCAACATCAGTTAGAATTATGGCAATCCATTGTTATTTTGATTTTGCAACTAATGGTTCTTATTGGCTTTTATATTTTGGCTAGAAAGAGAAAGTTAATTAGTTCGGGAATCAAGTATTGGTTGAGTTGGAAAACATTGGGAATTGCTTCTTTGGGTTTTGTTGCTCTCTTTATTGTCAAAATTATTGCTGGCATCATTTTGACTTATGAAGGAAAAACAACAACCAATAATCAAGAGACAATCACTCAAATGTTTAACAATTCATCGTTATTGCTGATGTTCATGTTTATTGTTATTATCGCTCCTTTAACAGAAGAAATTATCTTTAGGGGACTTATTCCTCAACTATTTTCCAAACGTTTTGAAGGACTTGGTTTTGGACTTGGAGCTTTGCTTTTTGGTTTACTTCATGGTCCAAGTGATATTGGTAGTTTTGTTCTTTATGTGGGAATGGGTACTATTTTAGCTTTTATTTGTTATAAACTTAAACATTTGGAATACAGTATTTGGACTCATGCACTTAACAATGGTCTCGGTTTTCTGCTATTATTATTTAAATAA","10.70","10.90","24712","MKTILKKTAAVIAIVGLFIVSQLPSIVMALWQRNQHQLELWQSIVILILQLMVLIGFYILARKRKLISSGIKYWLSWKTLGIASLGFVALFIVKIIAGIILTYEGKTTTNNQETITQMFNNSSLLLMFMFIVIIAPLTEEIIFRGLIPQLFSKRFEGLGFGLGALLFGLLHGPSDIGSFVLYVGMGTILAFICYKLKHLEYSIWTHALNNGLGFLLLLFK","1848312","","conserved hypothetical protein","Membrane, Cytoplasm","Several weak matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 2-206 are 28% similar to conserved hypothetical protein of Streptococcus pneumoniae (gi|15902309).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0172 (3e-25).","

InterPro
IPR003675
Family

Abortive infection protein
PF02517	$\"[126-217]T$	Abi

","BeTs to 4 clades of COG1266COG name: Predicted membrane proteinFunctional Class: SThe phylogenetic pattern of COG1266 is --T--qvC-BR-----o-in-Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 09:01:00 2002","Wed Jan 16 12:19:40 2002","Wed Jan 16 12:19:40 2002","Wed Jan 16 12:19:40 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1793 is paralogously related (blast p-value < 1e-3) to SMu0604, a predicted conserved hypothetical protein; possible membrane protein.","Mon Apr 15 09:01:00 2002","","No significant hits to the NCBI PDB database.","SMU.1975c","","Residues 126 to 217 (E-value = 1.7e-16) place SMu1793 in the Abi family which is described as CAAX amino terminal protease family (PF02517)","Wed Jan 16 12:19:40 2002","24380319","","","","","","1","","","SMU.1975c","886" "SMu1794","1849451","1849011","441","ATGTTTCAAAATTTAGGAAAGAAAAAAAGTAAGGAAGAATATAAAAAATCACAGCAGGCAATCGGCAGCTGTCTGATATGTATTGGTGGTTTACTACTGGTTTTATCTTTAAGTGTATCAATGTCAGATTTTGCAGCGGGATTTTTGATAGGAATTAGCATTGGTATGAACCTATTGGGAATCATAGCTTTTACAAAAACTACAACTGATAAGACATTGACACGCTACTACATAGCAGCTTATGATGAGCGTAATAAACGAATTCGTAGTTTGACAGCACAGTTAACTTTGGCTGTTTTAATATTGTTGATAGTAGCTTTAGTAGTTTTATATGCTTTTTGGCATATCGCTTTCAGCTATCTGATTACTCTGATGATTCTTCTTTATGGGACAATCATATGTGGCGTTTTACTTAGAGTGTTCTTCAATCACTTATTGTGA","10.40","8.32","16259","MFQNLGKKKSKEEYKKSQQAIGSCLICIGGLLLVLSLSVSMSDFAAGFLIGISIGMNLLGIIAFTKTTTDKTLTRYYIAAYDERNKRIRSLTAQLTLAVLILLIVALVVLYAFWHIAFSYLITLMILLYGTIICGVLLRVFFNHLL","1849027","","conserved hypothetical protein","Membrane, Cytoplasm","A very weak match to Spy0110.This sequence is similar to Sag0171 and to S. thermophilus GI:62526671.","

noIPR
unintegrated

unintegrated
signalp	$\"[1-47]?$	signal-peptide
tmhmm	$\"[21-41]?$ $\"[47-69]?$ $\"[90-110]?$ $\"[116-138]?$	transmembrane_regions

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[5-59]T$	HTH_3
SM00530	$\"[4-59]T$	HTH_XRE
PS50943	$\"[5-59]T$	HTH_CROC1

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[1-65]T$	Lambda_like_DNA

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[3-65]T$	G3DSA:1.10.260.40

","BeTs to 4 clades of COG1476COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1476 is Amt------b-----------Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 5-53 are 59% similar to a (COMPLETE PROTEOME REGULATOR) protein domain (PD284760) which is seen in YD28_METTH.Residues 4-65 are 58% similar to a (PROTEOME TRANSCRIPTIONAL REGULATOR) protein domain (PD222678) which is seen in Q9V101_PYRAB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 09:03:58 2002","Wed Aug 30 15:25:01 2006","Wed Aug 30 15:25:01 2006","Wed Jan 16 12:14:41 2002","","Wed Jan 16 12:14:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1795 is paralogously related (blast p-value < 1e-3) to SMu0603, SMu0151 and SMu0737,all predicted transcriptional regulators and SMu1274,a predicted conserved hypothetical protein.","Mon Apr 15 09:03:58 2002","","No significant hits to the NCBI PDB database.","SMU.1977c","","Residues 5 to 59 (E-value = 1e-15) place SMu1795 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Wed Jan 16 12:14:41 2002","24380321","","","","","","1","","","SMU.1977c","1001" "SMu1796","1851433","1850234","1200","ATGTCAAAAACTATTTCAATTAATGCAGGTTCTTCTAGCCTTAAATGGCAGCTATACTTGATGCCTGAAGAAAAAGTACTTGCAAAGGGGTTAATTGAGCGTATTGGCAAGGATGATGCTATTTCTACTGTAAAATTTAATGGTCAAGAAGCTTCAGAAACCTTAGCTATTAAAGACCATACTGCAGCAGTGAAAATTCTCTTAGATGATTTAATCCATTTGGATATTATTAAATCGTATGATGAAATCACAGGTGTAGGGCACCGTGTAGTTGCTGGTGGAACTTACTTTAATGAATCCGCTTTAGTTGATAGTGAAGAAGTCATTAAAAAGGTTGAAGAGTTAGCACTCTTAGCGCCCTTGCATAATAAAGCAAATGCTGCAGGAATTCGAGCATTTAAGAAAATTCTACCAGATATTACCAGTGTCGTTGTCTTTGATACTGCTTTCCACACTACGATGCCGGAGGTTGCCTACCGCTATCCATTGCCGAATAAGTATTTTACAGAAAATCAGGTTCGTAAATATGGAGCTCATGGAACTAGCCATTATTATGTTGCTCATGAAGCAGCCAAAATATTAGAAAAACCGATTGAAAAACTTAAATTGATTACGGTTCATATGGGAAACGGGGTTTCTCTTACGGCAGTTGATGGCGGAAAGTCAGTTGACACGTCAATGGGCTTTACACCACTGGGTGGTGTGATGATGGGAACACGAACGGGAGATCTTGATCCAGCCGTTATTCCTTATTTAATGGATAATACAGAAGATTTTAAAACACCAGAAGATATTCGCCGTATTTTCAATAATGAGTCAGGTTTGCTGGGGATTTCTGAGTTATCAAATGATATGCGTGAAATTGAGGCGGCTACAGCAGCTGGTAATAAGAATGCTACCTTGGCTTATAACATGTTCATTGACCGTATTATTAAGCATATTGGTGCTTACGCTGCTGTGATGAATGGAGTTGATGCTATTGTCTTTACGGCGGGTATTGGTGAAAATGATGCTCATATTCGAAGCGAAATTATGAAACACTTTGATTGGCTTGGAGCTGATATCGTTACCGAAAAGAACGAAAAGCGTCCAGTTTACGGGGTCATATCATCGAATGCCGCTAAAGTTAAAGTTTTGGTGATTCCCACTGATGAAGAGCTTGTTATTGCACGTGATGTCGAGCGTTTGAAAACTAAATAA","6.10","-6.08","43721","MSKTISINAGSSSLKWQLYLMPEEKVLAKGLIERIGKDDAISTVKFNGQEASETLAIKDHTAAVKILLDDLIHLDIIKSYDEITGVGHRVVAGGTYFNESALVDSEEVIKKVEELALLAPLHNKANAAGIRAFKKILPDITSVVVFDTAFHTTMPEVAYRYPLPNKYFTENQVRKYGAHGTSHYYVAHEAAKILEKPIEKLKLITVHMGNGVSLTAVDGGKSVDTSMGFTPLGGVMMGTRTGDLDPAVIPYLMDNTEDFKTPEDIRRIFNNESGLLGISELSNDMREIEAATAAGNKNATLAYNMFIDRIIKHIGAYAAVMNGVDAIVFTAGIGENDAHIRSEIMKHFDWLGADIVTEKNEKRPVYGVISSNAAKVKVLVIPTDEELVIARDVERLKTK","1850250","From GenBank (gi:584719): In B.subtilis, this protein is involved in the secretion of excess carbohydrate. It catalyzes interconversion of acetate and acetyl phosphate and appears to favor the formation of acetate by the reaction: ATP + acetate = ADP + acetyl phosphate. Its activity is induced by glucose excess; the induction may be mediated by CcpA transcriptional regulator. It is involved in the first of two steps in the conversion of acetate to acetyl-CoA. This cytoplasmic protein belongs to the acetokinase family. ","acetate kinase","Cytoplasm","Many strong matches in gapped BLAST to acetate kinase; e.g. residues 1-397 are 67% similar to acetate kinase of Streptococcus pneumoniae (gi15901865); residues 1-397 are 59% similar to acetate kinase of Streptococcus pyogenes (gi15674332). See Spy0109.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0168 (1e-130).","

InterPro
IPR000890
Family

Acetate and butyrate kinase
PR00471	$\"[4-15]T$ $\"[173-186]T$ $\"[203-224]T$ $\"[302-315]T$ $\"[324-340]T$ $\"[378-390]T$	ACETATEKNASE
PTHR21060	$\"[1-398]T$	Acetate_kin
PF00871	$\"[3-391]T$	Acetate_kinase
PS01075	$\"[4-15]T$	ACETATE_KINASE_1
PS01076	$\"[203-220]T$	ACETATE_KINASE_2

InterPro
IPR004372
Family

Acetate kinase
PIRSF000722	$\"[2-399]T$	Acetate_prop_kin
PTHR21060:SF11	$\"[1-398]T$	AckA
TIGR00016	$\"[1-398]T$	ackA

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.40	$\"[2-183]T$	G3DSA:3.30.420.40
SSF53067	$\"[2-155]T$ $\"[156-399]T$	SSF53067

","BeTs to 10 clades of COG0282COG name: Acetate kinaseFunctional Class: CThe phylogenetic pattern of COG0282 is ------VcEBrhujgpol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB000890 (Acetate and butyrate kinase) with a combined E-value of 3.7e-95. IPB000890A 4-15 IPB000890B 85-95 IPB000890C 118-130 IPB000890D 143-164 IPB000890E 173-186 IPB000890F 206-244 IPB000890G 269-280 IPB000890H 325-336 IPB000890I 381-390","Residues 3-378 are 56% similar to a (KINASE ACETATE TRANSFERASE ACETOKINASE) protein domain (PD003226) which is seen in Q9CE35_LACLA.Residues 2-168 are 52% similar to a (KINASE ACETATE TRANSFERASE ACETOKINASE) protein domain (PD348124) which is seen in ACKA_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Jan 16 12:09:06 2002","Wed Jan 16 12:09:06 2002","Tue Feb 21 10:09:16 2006","Wed Jan 16 12:09:06 2002","Wed Jan 16 12:09:06 2002","Wed Jan 16 12:09:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1796 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 15 11:17:22 2002","Wed Feb 9 11:00:24 2005","pdb1G99A Chain A, An Ancient Enzyme: Acetate Kinase From Meth... 342 6e-095","SMU.1978c","","Residues 3 to 391 (E-value = 5.9e-188) place SMu1796 in the Acetate_kinase family which is described as Acetokinase family (PF00871)","Wed Jan 16 12:09:06 2002","","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","Grundy FJ, Waters DA, Allen SH, Henkin TM.Regulation of the Bacillus subtilis acetate kinase gene by CcpA.J Bacteriol. 1993 Nov;175(22):7348-55.PMID: 8226682","Wed Feb 9 11:06:02 2005","Wed Feb 9 11:06:02 2005","1","","","SMU.1978c","244" "SMu1797","1852445","1851492","954","ATGGATTTTGAAAAAATAGAAGCTGCCTATAACTTACTGTTAGATAATTGTCAAAGGCTGGAAACTCAACTTCATACTCACCTTTATGATGCCTTAATTGAGCAAAATGCTTGCTATCTAGGTGCTGAAGGTGCTGATGATTTTATTAAAGAAAATAATAAAAAACTGCGTCAGCTTAATCTAAGTAAAGAGGAGTGGCGTCGTAGTTTTCAATTTATTTTTATTAAGGCTACTCAAAGTCAGCAATTACAGTCAAATCACCAATTTACACCAGATAGTATTGGTTTTATTATTCTTTATTTATTGGAAGGTTTAACAAATAAGAGTCAGTTAGACATCATTGAAATTGGTTCTGGGACAGGAAATCTTGCAGAGACTATTGTGAATAACAGTTCAAAAAGCATTGATTATATGGGGATTGAGGTTGACGATCTGTTAATTGATTTATCAGCAAGTATTGCCGATGTATTGGATTCTTCTGTGCATTTTGTTCAAGAAGATGCAGTGCGGCCTCAGATTTTAAAAGAAAGTGATATCATTATCAGTGATCTGCCAGTTGGCTTTTATCCCAATGATAAAATTGCTCAGCGTTATCAGGTTGCAGCCAAGTTAGGACATACTTATGCACATCATCTTTTGATGGAGCAATCGCTTAAGTATTTAAAAAAAGAGGGACTTGCTATTTTTTTAGCGCCAGTGGATCTTTTAACTAGTGAGCAGAGTCCTTTGCTTAAAAAGTGGTTACAGAACAATGTAACTATTTTAGCCGTTATTTCTTTACCTGAGGCAATTTTTAAACAGAAAAGTAATATAAAGTCAATCTTTGTCTTAAAGAAACAATCGCAACAAAGTTTGGAAAGTTTTGTCTATCCTTTGACAGATTTACAAGACCCCGAAGTTTTAAGACGATTTATGAAAAATTTTAAAAAGTGGAAGGAAGATAATGTCTTTTAA","5.30","-7.39","36259","MDFEKIEAAYNLLLDNCQRLETQLHTHLYDALIEQNACYLGAEGADDFIKENNKKLRQLNLSKEEWRRSFQFIFIKATQSQQLQSNHQFTPDSIGFIILYLLEGLTNKSQLDIIEIGSGTGNLAETIVNNSSKSIDYMGIEVDDLLIDLSASIADVLDSSVHFVQEDAVRPQILKESDIIISDLPVGFYPNDKIAQRYQVAAKLGHTYAHHLLMEQSLKYLKKEGLAIFLAPVDLLTSEQSPLLKKWLQNNVTILAVISLPEAIFKQKSNIKSIFVLKKQSQQSLESFVYPLTDLQDPEVLRRFMKNFKKWKEDNVF","1851508","","conserved hypothetical protein, methyltransferase domain","Cytoplasm","Several strong matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-316 are 65% similar to conserved hypothetical protein of Streptococcus pyogenes (gi:15674331).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0167 (1e-125).","

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[88-280]T$	G3DSA:3.40.50.150
SSF53335	$\"[88-311]T$	SSF53335

","BeTs to 4 clades of COG0500COG name: SAM-dependent methyltransferasesFunctional Class: RThe phylogenetic pattern of COG0500 is AMTKYQVCEBRHUJgPOLINXNumber of proteins in this genome belonging to this COG is 14","No significant hits to the Blocks database.","Residues 209-279 are 45% similar to a (METHYLTRANSFERASE RESTRICTION METHYLASE) protein domain (PD011355) which is seen in YTXK_BACSU.Residues 1-208 are 47% similar to a (PROTEOME COMPLETE YUJA ACKA-SSPA) protein domain (PD133062) which is seen in Q9CE34_LACLA.Residues 210-310 are 48% similar to a (PROTEOME COMPLETE YUJA BH3193) protein domain (PD414739) which is seen in Q9CE34_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 09:05:26 2002","Tue Sep 5 17:49:11 2006","Wed Feb 9 11:12:19 2005","Wed Jan 16 12:02:20 2002","","Wed Jan 16 12:02:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1797 is paralogously related (blast p-value < 1e-3) to SMu0314, a predicted dimethyladenosine transferase.","Mon Apr 15 09:05:26 2002","","No significant hits to the NCBI PDB database.","SMU.1979c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 12:02:20 2002","24380323","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","","Tue Sep 5 17:49:11 2006","","1","","","SMU.1979c","243" "SMu1798","1852889","1852500","390","ATGCTTTTCATGAAAAAAATTAAAGCAGGCGTACTTCTATATGCTCTGTTTATGTCAGCAATCTTTAGTCTTTTCTTACAATTTTATCTTAATCGTGTTGTAGCAACAGAGAGACAAAATCAGGCACAATTATCGGCCAGTAAAGCTTATCTTATAGCAGATCTAACTCAAGATTTGGCTAAAGACAACTTTGGGCAGTTGACTTTTAATCACGGAAGGTCTAGTTATCATAAACAGGAAGGAGAACTTCTGATAAAAGTCCATTTGACAGATGGTCAGTCCTACCAATATCGTTTTAACTGTGTAACAGAAAATAAGGAAAAAGGAAAATTTAGTGTGGCTAATAAAACTTTTACTAAATCTATAGAAAAACGTCATTTTCAAAAATAG","10.60","9.90","14938","MLFMKKIKAGVLLYALFMSAIFSLFLQFYLNRVVATERQNQAQLSASKAYLIADLTQDLAKDNFGQLTFNHGRSSYHKQEGELLIKVHLTDGQSYQYRFNCVTENKEKGKFSVANKTFTKSIEKRHFQK","1852516","","conserved hypothetical protein","Membrane, Cytoplasm, Extracellular","Two weak matches in gapped BLAST to conserved domain proteins; e.g. residues 5-129 are 38% similar to conserved domain protein of Streptococcus pneumoniae (gi:15901867).See Spy0107.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0166 (2e-18).","

InterPro
IPR002035
Domain

von Willebrand factor, type A
PR00453	$\"[47-64]T$ $\"[85-93]T$	VWFADOMAIN

noIPR
unintegrated

unintegrated
signalp	$\"[1-22]?$	signal-peptide
tmhmm	$\"[9-29]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 23-142 are 42% similar to a (PROTEOME COMPLETE YVII ORF150) protein domain (PD176302) which is seen in Q9CDU3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Feb 9 14:53:23 2005","Thu Sep 7 09:17:57 2006","Tue Feb 21 09:52:43 2006","Wed Jan 16 11:58:14 2002","","Wed Jan 16 11:58:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1799 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:49:24 2002","","No significant hits to the NCBI PDB database.","SMU.1981c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 11:58:14 2002","24380325","","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","Tue Feb 21 09:52:43 2006","Tue Feb 21 09:52:43 2006","1","","","SMU.1981c","885" "SMu1800","1853581","1853288","294","GTGGTCAGTATAAAAAAACAGAAAGTTAAAGCTTATATTCTTCTAGAAAGTTTAGTTGCTTTGGGGCTTTTCGTAACCATCACAACTTTAATTCTTACTCAGTTGAGTCATTATCAGGAAAGAACAGCTAAAAATTTACAAAAACAAGAAATATTGAATTTAGCAATAATGGCTCTTCAAACTCAGCAAGATCATTTAAGCTTCAACGGCGTCAGTGTTACGGTTGTTAAAAATCAAGGGGAAACTATAGTTTATCATGATCATGAGGAGGTTATCAATCTTGTTAAAAAGTAA","9.80","2.95","10953","MVSIKKQKVKAYILLESLVALGLFVTITTLILTQLSHYQERTAKNLQKQEILNLAIMALQTQQDHLSFNGVSVTVVKNQGETIVYHDHEEVINLVKK","1853304","","conserved hypothetical protein","Membrane, Cytoplasm","Few weak matches in gapped BLAST to conserved hypothetical proteins; e.g.residues 13-92 are 45% similar to conserved hypothetical protein of Streptococcus pneumoniae gi:15901869. See Spy0105.SMu1800 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-30]?$	signal-peptide
tmhmm	$\"[12-32]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 3-94 are 32% similar to a (PROTEOME COMPLETE YVIJ) protein domain (PD174894) which is seen in Q9CDU2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:43:50 2002","Wed Jan 16 11:39:41 2002","Tue Feb 21 09:49:20 2006","Wed Jan 16 11:39:41 2002","","Wed Jan 16 11:39:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1800 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:43:50 2002","","No significant hits to the NCBI PDB database.","SMU.1982c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 11:39:41 2002","24380326","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","","Tue Feb 21 09:49:20 2006","","1","","","SMU.1982c","" "SMu1801","1853984","1853553","432","ATGCAAAACACCCAAGTAAAACACGGCATGTCGCGAATTAAAGCTTTTACGCTTATAGAAAGTTTAGTGACTTTGGCAATTACTAGTTTTTTGATTTTAAGCTTTTCAGGTAGTATAACTCAAACGTTTGCCAAAGTAGAAGAGCGTCTCTTTTTTCTTTCTTTTGAACATCTTTACCGTGACACGCAAAAACTTAGTGTTTATCAAAGACAAGATATGACTTTAATATTAAAAAGCGAATATATCTCAAATGGTGTTGAAGTACTTAAAATCCCTAAGGATGTCAAACTAGAGAGGAATAAAACTTTGCACTTTGATCAGGCAGGAGGAAATTCTTCTTTAGAAAAACTTGTTTTTCAAACATCTGATGAAAAAAGAGTTACTTATCAATTATATATAGGAAGTGGTCAGTATAAAAAAACAGAAAGTTAA","10.10","4.71","16453","MQNTQVKHGMSRIKAFTLIESLVTLAITSFLILSFSGSITQTFAKVEERLFFLSFEHLYRDTQKLSVYQRQDMTLILKSEYISNGVEVLKIPKDVKLERNKTLHFDQAGGNSSLEKLVFQTSDEKRVTYQLYIGSGQYKKTES","1853569","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1802 (comYC); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).For other 'cgl' genes see SMu1804 (cglA);SMu1803 (cglB) and SMu1802 (cglC). ","competence protein ComYD","Membrane, Cytoplasm","Few moderate matches in gapped BLAST to competence proteins;e.g. residues 1-140 are 46% similar to Competence protein of Streptococcus pneumoniae (gi:15903902); residues 6-141 are 44% similar to competence protein of Streptococcus pyogenes (gi:15674327). See Spy0104.SMu1801 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR012902
PTM

Prepilin-type cleavage/methylation, N-terminal
TIGR02532	$\"[13-36]T$	IV_pilin_GFxxxE

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 13-140 are 49% similar to a (COMPETENCE PROTEOME COMPLETE COMGD) protein domain (PD175279) which is seen in O85196_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 21 09:47:51 2006","Wed Jan 16 11:36:20 2002","Tue Feb 21 09:46:59 2006","Wed Jan 16 11:36:20 2002","","Wed Jan 16 11:36:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1801 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 10:08:23 2002","","No significant hits to the NCBI PDB database.","SMU.1983c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 11:36:20 2002","","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","Pestova EV, Morrison DA.Isolation and characterization of three Streptococcus pneumoniae transformation-specific loci by use of a lacZ reporter insertion vector.J Bacteriol. 1998 May;180(10):2701-10.PMID: 9573156Lunsford RD, Roble AG.comYA, a gene similar to comGA of Bacillus subtilis, is essential for competence-factor-dependent DNA transformation in Streptococcus gordonii.J Bacteriol. 1997 May;179(10):3122-6.PMID: 9150204","Wed Feb 9 15:46:35 2005","Wed Feb 9 15:50:42 2005","1","","","SMU.1983c","" "SMu1802","1854258","1853944","315","ATGAAAAAGATCAAGAGAGTCAGTGTACGGGCTTTTACGCTTATAGAAATGTTAGTAGTTCTTCTCATTATTAGTATTCTTTTACTATTATTTGTTCCTAATTTAACTAAGCAAAAAGATAAGGTAAAAGATACTGGCGGTTCTGCCGTGGTTAAAGTTGTAGAAAGTCAGGCTGAGCTTTATGAGCTTAATAAAACCGATTCTGCTACTCTTTCTAAATTAGTAGCTAGTGGTGATATTACACAAGAACAGGCAAATTCATACAAGGATTACTATGCAAAACACCCAAGTAAAACACGGCATGTCGCGAATTAA","10.40","6.46","11575","MKKIKRVSVRAFTLIEMLVVLLIISILLLLFVPNLTKQKDKVKDTGGSAVVKVVESQAELYELNKTDSATLSKLVASGDITQEQANSYKDYYAKHPSKTRHVAN","1853960","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).For other 'cgl' genes see SMu1804 (cglA);SMu1803 (cglB) and SMu1801 (cglD). ","competence protein ComYC","Membrane, Cytoplasm, Extracellular","Some moderate matches in gapped BLAST to competence proteins;e.g. residues are 56% similar to ComYC of Streptococcus gordonii (gi:2058546); residues 1-1042 are 47% similar to competence protein of Streptococcus pneumoniae (gi:15903903). SMu1802 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiaeSee Spy0103.","

InterPro
IPR000983
Family

Bacterial general secretion pathway protein G
PR00813	$\"[11-36]T$ $\"[47-65]T$	BCTERIALGSPG

InterPro
IPR012902
PTM

Prepilin-type cleavage/methylation, N-terminal
PF07963	$\"[10-33]T$	N_methyl
TIGR02532	$\"[9-32]T$	IV_pilin_GFxxxE

noIPR
unintegrated

unintegrated
SSF54523	$\"[12-93]T$	SSF54523

","No hits to the COGs database.","***** PR00813 (Bacterial general secretion pathway protein G signature) with a combined E-value of 8.8e-08. PR00813A 11-36***** IPB001120 (Prokaryotic N-terminal methylation site) with a combined E-value of 1.3e-06. IPB001120 9-28","Residues 46-98 are 70% similar to a (COMPETENCE PROTEOME COMPLETE ORF125) protein domain (PD029711) which is seen in O06668_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 21 09:44:23 2006","Wed Jan 16 11:29:56 2002","Tue Feb 21 09:44:23 2006","Wed Jan 16 11:29:56 2002","Wed Jan 16 11:29:56 2002","Wed Jan 16 11:29:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1802 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 11:36:52 2002","","No significant hits to the NCBI PDB database.","SMU.1984c","","No significant hits to the Pfam 11.0 database","Wed Jan 16 11:29:56 2002","","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","Pestova EV, Morrison DA.Isolation and characterization of three Streptococcus pneumoniae transformation-specific loci by use of a lacZ reporter insertion vector.J Bacteriol. 1998 May;180(10):2701-10.PMID: 9573156Lunsford RD, Roble AG.comYA, a gene similar to comGA of Bacillus subtilis, is essential for competence-factor-dependent DNA transformation in Streptococcus gordonii.J Bacteriol. 1997 May;179(10):3122-6.PMID: 9150204","Thu Feb 3 14:20:00 2005","Wed Feb 9 15:53:45 2005","1","","","SMU.1984c","" "SMu1803","1855106","1854258","849","ATGCGACAAGGGTTGTTGAATGGTCTGCATTTGGCTGAAATAATGAGTTCTTTGGGATTCTCAGATGATGTTGTTACTCAATTAGCACTTTCTGAAGTTCATGGAAACACTCAAAAAAGTCTTTTAAAGATTGAATCTTATCTAAATAATCTGATACTTGTTAAAAAGAAATTAGTTGAGGTTATCACTTATCCGATCATTTTATTGATTTTTCTTGTCGTTATTATGTTGGGATTAAAGAATTATTTATTACCACAACTTGAAAGGGGAAATTTTGCGACTCGGTTGATTTCTAATTTCCCAATACTTTTCTTGCTGGGATGTTGCTTTTTTATTTTACTAGTTGGCATTTTTACTTTCTTTTCACGAAAGATCAGTCGTCTGCATTTAATTGGTTTTTGCAGCCATTTGCCTTTTGCTGGTAAGTATTTGCAACTTTATTTAACAGCTTATTATGCGCGTGAATGGGGTAATCTTATTGGGCAAGGAGTAGAAATGGCTCAGATAGTTAGATTGATGCAAGATCAAAAGTCACAACTTTTTAGAGAAATTGGCTATGATATGGAGAAGGCTCTGCTATCAGGTCAAGAGTTTCATCAAAAAGTTTTAGATTATCCTTTCTTTTTAAAAGAACTCAGCCTTATGATTGAATATGGAGAAGTAAAGTCAAAATTGGGAAATGAATTGGAAATTTATGCTGAGGAAACATGGGAACACTTTTTTGCAAAGTTAAAAAAAGCAACACAGTTTGTTCAGCCACTCATCTTTGTTTTTGTAGCTATTGTTATTGTTATGATTTATGCAGCCATGCTTTTGCCAATTTATCAGAATATGGAGGTTAATTTATAA","8.00","2.31","32484","MRQGLLNGLHLAEIMSSLGFSDDVVTQLALSEVHGNTQKSLLKIESYLNNLILVKKKLVEVITYPIILLIFLVVIMLGLKNYLLPQLERGNFATRLISNFPILFLLGCCFFILLVGIFTFFSRKISRLHLIGFCSHLPFAGKYLQLYLTAYYAREWGNLIGQGVEMAQIVRLMQDQKSQLFREIGYDMEKALLSGQEFHQKVLDYPFFLKELSLMIEYGEVKSKLGNELEIYAEETWEHFFAKLKKATQFVQPLIFVFVAIVIVMIYAAMLLPIYQNMEVNL","1854274","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1804 (comYA); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). For other 'cgl' genes see SMu1804 (cglA);SMu1802 (cglC) and SMu1801 (cglD). ","competence protein; general (type II) secretory pathway protein","Membrane, Cytoplasm","Several strong matches in gapped BLAST to competence proteins; e.g. residues 1-282 are 47% similar to ABC transporter subunit ComYB of Streptococcus gordonii (gi:2058545); residues 1-281 are 45% similar to Competence protein of Streptococcus pneumoniae (gi:15903904). See Spy0102.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0164 (3e-77).","

InterPro
IPR001992
Family

Bacterial type II secretion system protein
PF00482	$\"[1-85]T$ $\"[152-273]T$	GSPII_F

InterPro
IPR003004
Family

Bacterial general secretion pathway protein F
PR00812	$\"[57-85]T$ $\"[246-260]T$ $\"[262-281]T$	BCTERIALGSPF

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 36-279 are 44% similar to a (PROTEOME COMPLETE F SECRETION) protein domain (PD190313) which is seen in O06667_STRGC.Residues 1-35 are 71% similar to a (COMPETENCE PROTEOME SUBUNIT COMPLETE) protein domain (PD039976) which is seen in O06667_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 14:25:23 2007","Tue Aug 22 10:34:00 2006","Tue Feb 21 09:41:08 2006","Wed Jan 16 11:23:22 2002","","Wed Jan 16 11:23:22 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1803 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 11:23:57 2002","","No significant hits to the NCBI PDB database.","SMU.1985c","","Residues 150 to 273 (E-value = 5.1e-21) place SMu1803 in the GSPII_F family which is described as Bacterial type II secretion system protein F domain (PF00482)","Wed Jan 16 11:23:22 2002","","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","Pestova EV, Morrison DA.Isolation and characterization of three Streptococcus pneumoniae transformation-specific loci by use of a lacZ reporter insertion vector.J Bacteriol. 1998 May;180(10):2701-10.PMID: 9573156Lunsford RD, Roble AG.comYA, a gene similar to comGA of Bacillus subtilis, is essential for competence-factor-dependent DNA transformation in Streptococcus gordonii.J Bacteriol. 1997 May;179(10):3122-6.PMID: 9150204","Wed Feb 9 15:56:34 2005","Wed Feb 9 16:00:40 2005","1","","","SMU.1985c","515" "SMu1804","1856166","1855225","942","ATGGTTCAAAAATTAGGTAGAAAAATCATTGCCGAAGCTGTTCAAAATAAAGCACAAGATATCTATATTATTCCTAAAAAAGAATCTTATGAGCTTTATATGAGAATAGGGAATGAAAGGAGGTTCATTGATGTTTATGACCATCATTTCATGGCTAATCTTATTAGTCACTTTAAATTTGTTGCAGGAATGAATGTTGGTGAGAAAAGACGAAGTCAGCTGGGCTCTTGTGATTATTCTTATGATGAAGGGAAAGTTATTTCATTAAGGTTATCAAGTGTAGGAGATTATCGTGGTTATGAAAGTTTGGTTATTCGCTTACTTTTTTCTGGACGTCACGATTTAAAATTCTGGTTTAACAGTATGGATTTGATTTTAAATGAAATCAAGGGGCGAGGGCTTTATCTTTTTTCGGGTCCAGTTGGAAGTGGCAAAACAAGTTTGATGTATCAATTGGTAAAACTAAGATTTGAGACCAAACAGGTAATTACCATTGAAGATCCTGTGGAAATTAAGCAAGATAATATGTTACAACTGCAGCTTAATGAAAGCATTGATATGACTTATGATAATTTAATTAAATTATCTCTGAGGCATCGTCCGGATATTTTAATTATTGGAGAAATTCGAGATAAAGAAACCGCCAGAGCTGTTATTAGAGCAAGTCTTACAGGGGCAATGGTATTCTCAACTATCCATGCTAAAAGCATTCCAGGTGTTTATGCTAGGATGTTAGAATTGGGTACTAGTTCAGAAGAATTACAAAATGCTTTGCGTGGTATTGTTTATCAACGTTTAATAGGGGGAGGAGGGATTATTGACTTTGCCAAAGGGGATTATCAAAACCACTCAGCAAAAAAGTGGAACAAACAAATTTATGACCTTTTTACAGCAGGATATATCACTGAAGGAGAAGCACAAGCAGAAGAAATTGAAGATTAA","8.40","2.66","35726","MVQKLGRKIIAEAVQNKAQDIYIIPKKESYELYMRIGNERRFIDVYDHHFMANLISHFKFVAGMNVGEKRRSQLGSCDYSYDEGKVISLRLSSVGDYRGYESLVIRLLFSGRHDLKFWFNSMDLILNEIKGRGLYLFSGPVGSGKTSLMYQLVKLRFETKQVITIEDPVEIKQDNMLQLQLNESIDMTYDNLIKLSLRHRPDILIIGEIRDKETARAVIRASLTGAMVFSTIHAKSIPGVYARMLELGTSSEELQNALRGIVYQRLIGGGGIIDFAKGDYQNHSAKKWNKQIYDLFTAGYITEGEAQAEEIED","1855241","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu1814 (comX1); SMu0258 (comA);SMu0259 (comB);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD).For other 'cgl' genes see SMu1803 (cglB);SMu1802 (cglC) and SMu1801 (cglD). ","late competence protein; type II secretion system protein E","Cytoplasm","Many strong matches in gapped BLAST to ABC transporter subunit ComYA/competence protein; e.g. residues 1-313 are 67% similar to of Streptococcus gordonii (gi:2058544); residues 1-311 are 65% similar to competence protein CglA of Streptococcus pneumoniae (gi:15901873). See Spy0101.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0163 (1e-122).","

InterPro
IPR001482
Domain

Bacterial type II secretion system protein E
PD000739	$\"[136-202]T$	GSPII_E
PF00437	$\"[1-270]T$	GSPII_E
PS00662	$\"[197-211]?$	T2SP_E

noIPR
unintegrated

unintegrated
G3DSA:3.30.450.90	$\"[2-108]T$	G3DSA:3.30.450.90
G3DSA:3.40.50.300	$\"[124-308]T$	G3DSA:3.40.50.300
SSF52540	$\"[2-268]T$	SSF52540

","BeTs to 13 clades of COG0630COG name: Predicted ATPases involved in pili biogenesisFunctional Class: NThe phylogenetic pattern of COG0630 is AMtK-QVCEbrhUJ----inxNumber of proteins in this genome belonging to this COG is 2","***** IPB001482 (Bacterial type II secretion system protein E) with a combined E-value of 2.1e-29. IPB001482A 18-40 IPB001482B 131-153 IPB001482C 161-171 IPB001482D 193-237","Residues 268-311 are 56% similar to a (SUBUNIT COMPETENCE ABC TRANSPORTER) protein domain (PD098268) which is seen in O85193_STRPN.Residues 9-267 are 70% similar to a (COMPLETE PROTEOME SECRETION TYPE PLASMID ATP-BINDING) protein domain (PD000739) which is seen in O06666_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 17:44:18 2006","Tue Sep 5 17:44:18 2006","Tue Feb 21 09:34:18 2006","Wed Jan 16 11:07:20 2002","Wed Jan 16 11:07:20 2002","Wed Jan 16 11:07:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1804 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 16 11:24:51 2002","","No significant hits to the NCBI PDB database.","SMU.1987c","","Residues 1 to 270 (E-value = 5.4e-26) place SMu1804 in the GSPII_E family which is described as Type II/IV secretion system protein (PF00437)","Wed Jan 16 11:07:20 2002","","","Merritt J, Qi F, Shi W.A unique nine-gene comY operon in Streptococcus mutans.Microbiology. 2005 Jan;151(Pt 1):157-66.PMID: 15632435","Berg M, Moscoso M, Prudhomme M, Martin B, Claverys JP.Uptake of transforming DNA in Gram-positive bacteria: a view from Streptococcus pneumoniae.Mol Microbiol. 2002 Jul;45(2):411-21.PMID: 12123453Pestova EV, Morrison DA.Isolation and characterization of three Streptococcus pneumoniae transformation-specific loci by use of a lacZ reporter insertion vector.J Bacteriol. 1998 May;180(10):2701-10.PMID: 9573156Lunsford RD, Roble AG.comYA, a gene similar to comGA of Bacillus subtilis, is essential for competence-factor-dependent DNA transformation in Streptococcus gordonii.J Bacteriol. 1997 May;179(10):3122-6.PMID: 9150204","Wed Feb 9 16:06:43 2005","Wed Feb 9 16:07:32 2005","1","","","SMU.1987c","242" "SMu1805","1856679","1856296","384","ATGTATCAAGTAATCAGAATGTATGGGGCTATGGAACCGTGGTGGTTTTTAGATGATTGGAAAGAAGATATTACCAAGGTTCTTGAATTTGATAATTATCATGAAGCTTTGCAGTGTTATCAAAAAGAGTGGGCAAAATTACGTCGCCGTTATTCCGACTTTAACAGTCATGGCGATATTATGACAGCTTTTTGGAATAAACAAGATCAACATTGGTGCGAAGAATGTGGTGACTATGTACAGCGGTATCATTCTCTTGCGCTTTTAACTGACTGGCAGGAAACCCCTAGCTCTTGGTTTCGACCAACATTTACTAAACAAAATGATACCCCTTTTCGTTCCAAATGTTTTATTAAGCAAAAGAATGAACAAGGACAAAATTAG","6.10","-2.23","15695","MYQVIRMYGAMEPWWFLDDWKEDITKVLEFDNYHEALQCYQKEWAKLRRRYSDFNSHGDIMTAFWNKQDQHWCEECGDYVQRYHSLALLTDWQETPSSWFRPTFTKQNDTPFRSKCFIKQKNEQGQN","1856312","","probable DNA binding protein","Cytoplasm","Few moderate matches in gapped BLAST to DNA binding proteins and conserved hypothetical proteins; e.g. residues 1-121 are 47% similar to possible DNA binding protein of Streptococcus gordonii (gi2058543); residues 1-111 are 40% similar to possible DNA binding protein of Streptococcus pyogenes (gi15674323).See Spy0100.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0162 (1e-29).","

InterPro
IPR010434
Family

Protein of unknown function DUF1033
PF06279	$\"[1-121]T$	DUF1033

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-119 are 47% similar to a (PROTEOME BINDING COMPLETE DNA) protein domain (PD077394) which is seen in O06665_STRGC.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 11:01:08 2002","Tue Jan 15 14:22:33 2002","Fri Feb 17 13:51:10 2006","Tue Jan 15 14:22:33 2002","","Tue Jan 15 14:22:33 2002","yes","Mon Oct 21 10:17:47 2002","SMu1805 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 15 11:01:08 2002","","No significant hits to the NCBI PDB database.","SMU.1988c","","Residues 1 to 121 (E-value = 3.2e-89) place SMu1805 in the DUF1033 family which is described as Protein of unknown function (DUF1033) (PF06279)","Tue Jan 15 14:22:33 2002","24380331","","","","","","1","","","SMU.1988c","884" "SMu1806","1860463","1856807","3657","ATGAGAATTATAAGAAAGGTAAAATTAGTGGTTGACGTAAATCGTTTTAAAAGTATGCAAATCACATTAGCTTCGCCTAATAAAGTCCGTTCTTGGTCTTATGGTGAAGTTAAAAAACCTGAAACAATCAACTACCGCACACTGAAACCAGAACGTGAAGGTCTTTTTGACGAAGTTATTTTTGGACCTACTAAAGACTGGGAGTGTGCCTGTGGTAAATATAAACGTATTCGTTATAAAGGGATTGTTTGTGACCGTTGTGGTGTTGAAGTAACGCGCGCTAAAGTTCGCCGTGAACGTATGGGCCATATTGAGTTGAAGGCTCCGGTATCACACATTTGGTACTTTAAGGGAATTCCATCTCGTATGGGCTTAACACTTGATATGAGTCCTCGTGCCTTGGAAGAAGTTATTTATTTTGCGGCTTATGTGGTTATTGATCCTAAGGAAACACCGCTTGAAGCAAAATCGCTTTTGACAGAACGTGAATATCGTGAAAAACTTCAAGAATATGGCTCAGGTTCTTTTATTGCTAAGATGGGAGCTGAAGCTATTCAGGATTTGCTTAAACGGGTAGATCTTGATGCTGAAATTGCTGAATTAAAAGAAGAATTAAAAACAGCTTCAGGTCAAAAACGTGTAAAGGCCATTCGTCGTTTAGATGTGCTTGATGCCTTCCAAAAATCAGGTAATAAACCTGAATGGATGGTATTAAACATTTTACCGGTTATTCCACCAGATCTTCGCCCAATGTTGCAATTGGATGGTGGCCGCTTTGCGACATCTGACCTTAATGACCTTTATCGTCGTGTGATCAATCGGAACAATCGTTTGGCTCGCCTTTTGGAACTTAATGCACCGGGAATTATTGTCCAAAATGAAAAACGGATGCTGCAAGAGGCAGTTGATGCTTTGATTGATAATGGCCGTCGTGGTCGCCCAATTACTGGACCAGGTAGTCGTCCTCTGAAATCTCTCAGTCAAATGTTAAAGGGGAAACAAGGACGTTTCCGTCAAAACTTGCTGGGTAAACGTGTTGACTTTTCAGGACGCTCTGTTATCGCTGTTGGACCAACGCTTAAAATGTATCAATGTGGTGTACCGCGTGAAATGGCTATTGAACTTTTCAAACCATTTGTGATGCGTGAAATTGTTGATCGGGATATTGTCCAAAATGTAAAAGCTGCTAAACGTTTAATTGAACGTGGCGATGACCGTATTTGGGATATTCTTGAGGAAGTTATTAAAGAGCACCCTGTTCTGCTTAACCGCGCCCCAACGCTTCACCGTTTGGGAATTCAGGCTTTCGAACCAGTTCTGATTGATGGTAAGGCACTTCGCCTTCATCCGCTTGCTTGTGAAGCCTACAATGCCGACTTTGATGGTGACCAAATGGCTATCCATGTTCCTCTGTCAGAAGAAGCACAAGCAGAAGCTCGTCTTCTCATGTTGGCAGCAGAGCACATTCTGAATCCTAAAGATGGAAAACCTGTTGTTACGCCATCTCAAGATATGGTTCTTGGGAATTATTATTTGACCATGGAAGGTGCTGATCGTGAAGGTGAGGGTATGGTCTTTAAGGATCGCGATGAAGCTGTTATGGCATACCGCAATGGTTATGTTCATCTCCACAGTCGTGTAGGTATCGCTGTTGATAGTATGCCTAATAAACCATGGACGGACGAACAACGACATAAGATCATGATAACAACTGTTGGTAAGATTCTCTTTAATGATATTATGCCGGCAGATCTTCCTTACCTTCAAGAACCAAACAATGCTAATCTGACGGATAAAACACCTGATAAGTATTTCTTAGCACCGGGCTCCAATATCCAAGAAGCTATTAAAAATCTTGATTTGAATATTCCATTTAAAAAGAAAAATCTTGGAAATATTATTGCTGAAATCTTCAAACGTTTCCGTACAACAGAAACATCAGCTTTCCTTGATAGGTTGAAGGATCTTGGTTATTATCATTCAACTTTAGCTGGTTTGACAGTTGGTATTGCTGATATTCCTGTCATTGATAATAAACAAGAGATCATTGATGCTGCTCACCATCGTGTTGAAGAAATTTCAAAAGCCTTCCGCCGAGGTCTTATGACTGATGATGATCGTTATGAAGCTGTTACAGCGACATGGCGTGATGCTAAGGAGCAATTGGAAGCACGTTTGGTTGAAACGCAGGATGCTAAGAATCCAATTGTTATGATGATGGATTCAGGAGCTCGTGGTAATATTTCCAACTTCTCTCAGCTTGCTGGTATGCGTGGTCTGATGGCTGCTCCTAATGGACGAATTATGGAATTGCCTATCCTTTCTAATTTCCGTGAAGGTCTGTCTGTTTTGGAAATGTTCTTCTCAACTCACGGAGCACGTAAAGGAATGACTGATACAGCCCTTAAGACTGCTGATTCAGGTTATCTAACTCGCCGTTTGGTTGATGTCGCTCAAGATGTCATTATTCGCGAAGATGATTGTGGTACAGATCGCGGTCTTACTATTACAGCTATTACAGACGGTAAAGAAGTGACTGAAACACTTGAAGAACGTCTGGTTGGCCGTTATACTAAAAAATCGGTAAGACATCCTGAAACCGGAGAGATTATCGCTAGTCCTGATACATTGATTACAGAAGATATGGCCCATTATATTGCTGAAGCTGGAGTCAGTGAAGTGACTATTCGTTCTGTCTTTACATGTAATACGCGTCATGGTGTTTGTCGTCACTGTTATGGAATAAATCTTGCTACTGGGGATGCTGTTGAGGTTGGTGAAGCAGTTGGTACAATTGCAGCTCAATCCATTGGTGAACCGGGTACACAGTTGACCATGCGTACTTTCCACACAGGAGGTGTGGCTTCAAATGCTGATATCACACAAGGTTTGCCTCGTATTCAAGAAATCTTTGAAGCTCGTAATCCAAAAGGTGAAGCCGTTATTACAGAAGTCAAAGGGCAAGTAACAGATATTGAGGAAGATGCTGCTACTCGGACGAAGAAGGTTTATGTCAAAGGAGCAACAGGTGAAGGAGAATACACAGTACCATTTACTGCTCGTATGAAAGTTCAAGTAGGTGATGAAGTTCATCGTGGTGCGCCACTGACTGAAGGTTCTATCCAACCTAAGCACTTACTTGAAGTTCGTGATACCTTATCTGTTGAAACTTATCTTCTTGCAGAAGTGCAAAAGGTTTATCGCAGTCAAGGGGTGGAAATCGGTGATAAACACGTTGAAGTAATGGTACGTCAAATGCTTCGCAAAGTACGTGTTATGGATCCGGGAGATACAGGTTTGCTTCCAGGCATTCTTATGGATATTGCCGATTTTACAGATGCCAACAGAGATATTGTTATTGCTGGTGGTATTCCTGCAACAAGCCGTCCAGTTCTTATGGGAATTACCAAGGCATCACTTGAAACAAATTCATTCTTATCTGCAGCTTCCTTCCAAGAAACAACACGTGTGCTTACAGATGCAGCTATTCGTGGTAAGAAAGATCATCTTCTAGGGCTTAAAGAAAATGTCATTATTGGTAAGATCATTCCGGCTGGTACTGGTATGGCGCGTTACCGTAATCTTGAACCATTGGCTGTCAATGAAATTGAAGTCATTGAAGATTCTGAAGAACAAGAGGACACAGTAGAAGAGTAA","6.80","-2.76","136086","MRIIRKVKLVVDVNRFKSMQITLASPNKVRSWSYGEVKKPETINYRTLKPEREGLFDEVIFGPTKDWECACGKYKRIRYKGIVCDRCGVEVTRAKVRRERMGHIELKAPVSHIWYFKGIPSRMGLTLDMSPRALEEVIYFAAYVVIDPKETPLEAKSLLTEREYREKLQEYGSGSFIAKMGAEAIQDLLKRVDLDAEIAELKEELKTASGQKRVKAIRRLDVLDAFQKSGNKPEWMVLNILPVIPPDLRPMLQLDGGRFATSDLNDLYRRVINRNNRLARLLELNAPGIIVQNEKRMLQEAVDALIDNGRRGRPITGPGSRPLKSLSQMLKGKQGRFRQNLLGKRVDFSGRSVIAVGPTLKMYQCGVPREMAIELFKPFVMREIVDRDIVQNVKAAKRLIERGDDRIWDILEEVIKEHPVLLNRAPTLHRLGIQAFEPVLIDGKALRLHPLACEAYNADFDGDQMAIHVPLSEEAQAEARLLMLAAEHILNPKDGKPVVTPSQDMVLGNYYLTMEGADREGEGMVFKDRDEAVMAYRNGYVHLHSRVGIAVDSMPNKPWTDEQRHKIMITTVGKILFNDIMPADLPYLQEPNNANLTDKTPDKYFLAPGSNIQEAIKNLDLNIPFKKKNLGNIIAEIFKRFRTTETSAFLDRLKDLGYYHSTLAGLTVGIADIPVIDNKQEIIDAAHHRVEEISKAFRRGLMTDDDRYEAVTATWRDAKEQLEARLVETQDAKNPIVMMMDSGARGNISNFSQLAGMRGLMAAPNGRIMELPILSNFREGLSVLEMFFSTHGARKGMTDTALKTADSGYLTRRLVDVAQDVIIREDDCGTDRGLTITAITDGKEVTETLEERLVGRYTKKSVRHPETGEIIASPDTLITEDMAHYIAEAGVSEVTIRSVFTCNTRHGVCRHCYGINLATGDAVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVASNADITQGLPRIQEIFEARNPKGEAVITEVKGQVTDIEEDAATRTKKVYVKGATGEGEYTVPFTARMKVQVGDEVHRGAPLTEGSIQPKHLLEVRDTLSVETYLLAEVQKVYRSQGVEIGDKHVEVMVRQMLRKVRVMDPGDTGLLPGILMDIADFTDANRDIVIAGGIPATSRPVLMGITKASLETNSFLSAASFQETTRVLTDAAIRGKKDHLLGLKENVIIGKIIPAGTGMARYRNLEPLAVNEIEVIEDSEEQEDTVEE","1856823","For other 'rpo' genes see, SMu0086 (rpoE); Smu0746 (rpoD); Smu1817 (rpoA); SMu1807 (rpoB) and SMu0433 (rpoZ).For DNA-directed RNA polymerase, delta subunit see SMu0086. For DNA-directed RNA polymerase, omega subunit see SMu0433. For DNA-directed RNA polymerase, beta subunit see SMu1807. For DNA-directed RNA polymerase, alpha subunit see SMu1817. ","DNA-directed RNA polymerase, beta' subunit","Cytoplasm","Numerous strong matches in gapped BLAST to DNA-dependent RNA polymerase, B' subunit; e.g. residues 10-1201 are 90% similar to DNA-dependent RNA polymerase, B' subunit of Streptococcus pyogenes (gi15674322); residues 10-1199 are 69% similar to DNA-dependent RNA polymerase, B' subunit of Bacillus subtilis (gi2507344).See Spy0099.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0161 (0.0).","

InterPro
IPR000722
Domain

RNA polymerase, alpha subunit
G3DSA:2.40.40.30	$\"[345-487]T$	no description
PF00623	$\"[343-485]T$	RNA_pol_Rpb1_2

InterPro
IPR006592
Domain

RNA polymerase, N-terminal
SM00663	$\"[234-513]T$	RPOLA_N

InterPro
IPR007066
Domain

RNA polymerase Rpb1, domain 3
PF04983	$\"[488-673]T$	RNA_pol_Rpb1_3

InterPro
IPR007080
Domain

RNA polymerase Rpb1, domain 1
G3DSA:3.90.1120.10	$\"[12-344]T$	no description
PF04997	$\"[13-341]T$	RNA_pol_Rpb1_1

InterPro
IPR007081
Domain

RNA polymerase Rpb1, domain 5
PF04998	$\"[780-1148]T$	RNA_pol_Rpb1_5

InterPro
IPR007083
Domain

RNA polymerase Rpb1, domain 4
PF05000	$\"[702-778]T$	RNA_pol_Rpb1_4

InterPro
IPR012754
Family

DNA-directed RNA polymerase, subunit beta-prime
TIGR02386	$\"[18-1194]T$	rpoC_TIGR: DNA-directed RNA polymerase, bet

noIPR
unintegrated

unintegrated
PTHR19376	$\"[13-547]T$ $\"[566-1196]T$	DNA-DIRECTED RNA POLYMERASE
PTHR19376:SF4	$\"[13-547]T$ $\"[566-1196]T$	DNA-DIRECTED RNA POLYMERASE BETA CHAIN

","BeTs to 17 clades of COG0086COG name: DNA-dependent RNA polymerase beta' subunit (split gene in Mjan, Mthe, Aful, and Synechocystis)Functional Class: KThe phylogenetic pattern of COG0086 is AMTKYqVCebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000722 (RNA polymerase, alpha subunit) with a combined E-value of 1e-99. IPB000722A 87-115 IPB000722B 233-250 IPB000722C 331-348 IPB000722D 420-438 IPB000722E 456-470 IPB000722F 474-513***** IPB000684 (Eukaryotic RNA polymerase II heptapeptide repeat) with a combined E-value of 2.5e-49. IPB000684A 86-132 IPB000684B 331-385 IPB000684C 431-478 IPB000684E 780-831 IPB000684F 906-945 IPB000684K 1166-1200","Residues 851-920 are 77% similar to a (RNA POLYMERASE BETA' DNA-DIRECTED) protein domain (PD002641) which is seen in O06664_STRGC.Residues 959-1094 are 29% similar to a (SUBUNIT POLYMERASE BETA' RNA) protein domain (PD123705) which is seen in O21238_RECAM.Residues 877-946 are 50% similar to a (RNA POLYMERASE DNA-DIRECTED SUBUNIT TRANSFERASE BETA') protein domain (PD001579) which is seen in RPOC_THEMA.Residues 361-419 are 37% similar to a (SUBUNIT CHLOROPLAST POLYMERASE BETA') protein domain (PD262066) which is seen in Q9TL05_NEPOL.Residues 542-620 are 84% similar to a (POLYMERASE RNA BETA' DNA-DIRECTED) protein domain (PD034961) which is seen in RPOC_STRPY.Residues 847-918 are 36% similar to a (RNA POLYMERASE DNA-DIRECTED CHAIN) protein domain (PD406905) which is seen in RPOC_UREPA.Residues 474-540 are 94% similar to a (RNA POLYMERASE DNA-DIRECTED BETA') protein domain (PD298347) which is seen in RPOC_STRPY.Residues 298-372 are 76% similar to a (RNA POLYMERASE DNA-DIRECTED SUBUNIT) protein domain (PD011201) which is seen in Q9KWU6_THEAQ.Residues 947-994 are 91% similar to a (POLYMERASE RNA BETA' DNA-DIRECTED) protein domain (PD378695) which is seen in RPOC_STRPY.Residues 749-828 are identical to a (RNA POLYMERASE DNA-DIRECTED SUBUNIT) protein domain (PD001122) which is seen in RPOC_STRPY.Residues 1136-1192 are identical to a (RNA POLYMERASE DNA-DIRECTED BETA') protein domain (PD000751) which is seen in O06664_STRGC.Residues 1009-1135 are 86% similar to a (RNA POLYMERASE DNA-DIRECTED BETA') protein domain (PD003181) which is seen in O06664_STRGC.Residues 296-373 are 98% similar to a (RNA POLYMERASE DNA-DIRECTED SUBUNIT) protein domain (PD000691) which is seen in RPOC_STRPY.Residues 10-295 are 89% similar to a (RNA POLYMERASE BETA' DNA-DIRECTED) protein domain (PD002077) which is seen in RPOC_STRPY.Residues 411-471 are 98% similar to a (RNA POLYMERASE DNA-DIRECTED SUBUNIT) protein domain (PD000656) which is seen in RPOC_STRPY.Residues 374-410 are 75% similar to a (RNA POLYMERASE DNA-DIRECTED BETA') protein domain (PD190242) which is seen in RPOC_STRPY.Residues 622-748 are 91% similar to a (RNA POLYMERASE DNA-DIRECTED SUBUNIT) protein domain (PD000956) which is seen in RPOC_STRPY.Residues 1059-1116 are 44% similar to a (RNA POLYMERASE DNA-DIRECTED CHLOROPLAST) protein domain (PD384441) which is seen in RPOD_MAIZE.Residues 843-920 are 36% similar to a (POLYMERASE RNA DNA-DIRECTED TRANSCRIPTION) protein domain (PD392624) which is seen in RPOD_EUGGR.Residues 296-323 are 92% similar to a (POLYMERASE RNA BETA' DNA-DIRECTED) protein domain (PD365590) which is seen in P95688_STAAU.Residues 294-381 are 33% similar to a (COMPLETE ORF MITOCHONDRION PROTEOME) protein domain (PD000146) which is seen in RPOC_PLAFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 12:31:16 2006","Wed Sep 27 12:31:16 2006","Wed Sep 27 12:31:16 2006","Wed Sep 27 12:31:16 2006","Tue Jan 15 14:10:25 2002","Wed Sep 27 12:31:16 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1806 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 15 14:14:47 2002","Fri Feb 17 13:48:25 2006","pdb1HQMD Chain D, Crystal Structure Of Thermus Aquaticus Core... 1138 0.0","SMU.1989c","","Residues 13 to 341 (E-value = 4e-144) place SMu1806 in the RNA_pol_Rpb1_1 family which is described as RNA polymerase Rpb1, domain 1 (PF04997)Residues 343 to 485 (E-value = 1.4e-83) place SMu1806 in the RNA_pol_Rpb1_2 family which is described as RNA polymerase Rpb1, domain 2 (PF00623)Residues 488 to 673 (E-value = 3.4e-69) place SMu1806 in the RNA_pol_Rpb1_3 family which is described as RNA polymerase Rpb1, domain 3 (PF04983)Residues 698 to 778 (E-value = 2.9e-25) place SMu1806 in the RNA_pol_Rpb1_4 family which is described as RNA polymerase Rpb1, domain 4 (PF05000)Residues 780 to 1148 (E-value = 1.1e-55) place SMu1806 in the RNA_pol_Rpb1_5 family which is described as RNA polymerase Rpb1, domain 5 (PF04998)","Fri Feb 17 13:48:25 2006","","","","Yang,X. and Price,C.W. Streptolydigin resistance can be conferred by alterations to either the beta or beta' subunits of Bacillus subtilis RNA polymerase. J. Biol. Chem. 270 (41): 23930-23933 (1995) [PubMed: 7592585].","","Wed Sep 27 12:31:16 2006","1","","","SMU.1989c","29" "SMu1807","1864235","1860672","3564","TTGGCAGGACATGAAGTTCAGTACGGGAAACATCGTACGCGTCGTAGTTTTTCAAGAATCAAAGAGGTTCTTGATTTACCAAATTTGATTGAAATCCAAACGGACTCTTTTAAAGATTTCTTGGATACAGGTCTGAAGGAAGTTTTTGAAGATGTGCTTCCAATTTCCAATTTCACAGACACTATGGAATTAGAGTTTGTGGGTTATGAGTTGAAAGAGCCTAAGTATACATTGGAAGAAGCACGTGCTCATGATGCACATTATTCTGCCCCCATCTTTGTTACTTTCCGTCTCATCAATAAAGAAACTGGTGAAATTAAGACACAAGAAGTATTTTTTGGTGATTTTCCCTTGATGACTGAAATGGGTACTTTTATTATTAATGGTGCTGAACGTATTATCGTTTCTCAGTTGGTACGTTCACCAGGTGTTTATTTTAATGATAAAGTGGATAAAAATGGGAAAATTGGCTATGGTTCAACTGTTATCCCTAACCGTGGTGCTTGGCTTGAGCTTGAAACGGACTCTAAGGATATTGCTTATACTCGTATTGACCGTACTCGTAAAATTCCTTTCACGACGCTGGTTCGTGCACTCGGTTTTTCCGGGGATGATGAGATTATTGATATTTTTGGTGATAGCGAATTGGTTCGTAATACCATTGAAAAAGATATCCATAAAAATCCTAATGACTCTCGTACAGATGAAGCTCTCAAGGAAATTTATGAACGTCTTCGTCCGGGTGAACCTAAGACGGCAGATTCTTCACGCAGTCTTCTGATTGCACGTTTCTTTGATGCGCGCCGTTATGATTTAGCAGCTGTTGGCCGCTATAAGATTAATAAGAAGTTAAACGTCAAAACGCGTCTTTTGAATCAAGTCATTGCTGAAAACTTAGTAGATCCTGAAACAGGCGAAATTCTTGTTGAAGCTGGGACTGAAATGACACGCAGTGTAATTGATTCGATTGCAGATTATCTTGATGGAGATCTCAATAAAATTGTTTATACGCCAAATGAATACGCTGTTTTGACAGAACCTGTTGTTCTTCAAAAATTCAAAGTTATGGCTCCAAATGATCCAGACCGCACGGTTACTGTTATTGGTAATGCCAGTCCAGATGACAAAGTACGTCACTTGACACCAGCCGATATTTTAGCTGAAATGTCTTATTTCCTTAACTTGGCTGAGGGTCTAGGTAAAGTTGATGATATTGACCATTTAGGCAACCGACGTATTCGTGCTGTTGGTGAATTGCTAGCTAATCAATTTCGTATTGGTTTGGCACGTATGGAACGCAATGTTCGTGAACGCATGTCCGTTCAAGATAATGAAGTCTTAACGCCACAACAGATTATTAACATTCGCCCTGTAACAGCGGCAATTAAAGAGTTTTTTGGTTCTTCTCAATTGTCACAGTTCATGGACCAACACAATCCACTGTCTGAACTGTCTCATAAACGCCGTTTGTCAGCTTTAGGTCCTGGTGGTTTAACACGCGACCGTGCTGGTTATGAAGTCCGTGATGTGCATTATACGCATTATGGTCGTATGTGTCCAATTGAAACGCCTGAAGGACCAAATATTGGATTGATTAATAACTTGTCTTCCTATGGTCATCTTAATAAATATGGATTTATCCAAACACCATACCGTAAAGTTGACCGTGAGACAGGTAAAGTAACCAATGAAATTGAATGGCTTACTGCTGATGAAGAAGATGAATTCACTGTAGCTCAGGCTAACTCAAAACTTAATGAAGATGGAAGCTTTGCTGAAGAAATCGTCATGGGACGTCATCAAGGGAATAACCAAGAGTTTCCAGCAAGTTCTGTTGAATATATGGATGTTTCTCCTAAACAGGTAGTTGCGGTAGCGACAGCATGTATTCCTTTCCTTGAAAATGATGACTCCAACCGTGCCCTTATGGGAGCTAACATGCAGCGCCAAGCTGTGCCATTGATTGATCCTAAAGCACCTTTTGTTGGAACTGGTATGGAATATCAAGCAGCCCATGATTCTGGAGCCGCTATTATCGCTCAACATAATGGGAAAGTGGTTTATTCCGATGCAGATAAGATTGAAGTTCGCCGTGAAGATGGCTCACTAGATGTTTATCATGTTACCAAATTCCGTCGTTCTAACTCTGGAACTGCCTACAATCAACGTACTCTTGTTAGGGTAGGCGATAGTGTCGAGAAGGGGGACTTTATTGCAGATGGTCCTTCTATGGAAAAGGGTGAGATGGCTCTTGGACAAAATCCAGTGGTTGCTTACATGACTTGGGAGGGTTACAACTTTGAAGATGCTGTTATCATGAGCGAGCGTCTTGTCAAGGATGATGTTTATACTTCTGTCCATTTAGAAGAATTTGAATCTGAAACTCGTGATACAAAGCTTGGACCTGAAGAAATTACGCGTGAAATCCCAAATGTTGGTGAAGATGCCCTGAAAGACCTTGATGAAATGGGAATTATTCGCATTGGTGCTGAGGTTAAAGAAGGTGATATTCTAGTTGGTAAAGTGACTCCTAAAGGAGAAAAAGATCTTTCTGCAGAAGAACGCCTCTTGCATGCCATTTTTGGTGACAAATCACGTGAAGTTCGTGATACTTCTCTTCGTGTACCTCATGGTGGCGACGGTGTTGTTTGTGATGTGAAAATCTTTACACGTGCTAATGGAGATGAACTTCAATCAGGTGTTAACATGCTGGTTCGTGTTTATATCGCTCAAAAACGTAAAATCAAGGTCGGAGATAAGATGGCCGGACGTCATGGTAATAAGGGTGTCGTTTCCCGTATTGTACCAGTGGAAGATATGCCATATCTTCCAGATGGAACACCTGTTGATATCATGCTTAATCCACTTGGGGTGCCATCACGGATGAACATTGGGCAAGTTATGGAACTCCATCTTGGTATGGCTGCTCGTAATTTGGGCATTCATATTGCAACGCCTGTCTTTGACGGAGCAACTTCTGATGATCTTTGGGAAACAGTAAAAGAAGCCGGTATGGATTCTGATGCTAAAACTGTTCTTTATGATGGTCGCACAGGGGAGCCGTTTGATAATCGTGTATCAGTTGGTGTTATGTATATGATTAAACTTCACCACATGGTTGATGATAAATTGCATGCACGTTCAGTTGGCCCTTATTCAACGATTACTCAACAGCCGCTTGGTGGTAAGGCTCAATTTGGTGGTCAACGTTTCGGAGAAATGGAAGTTTGGGCTTTGGAAGCTTATGGTGCCTCAAACGTTCTTCAAGAAATTTTAACTTATAAGTCAGATGATGTCACCGGTCGTCTTAAAGCCTATGAAGCTATTACAAAAGGTAAGCCAATTCCAAAACCAGGGGTACCAGAATCATTCCGTGTACTTGTGAAAGAACTGCAATCACTTGGACTTGATATGCGCGTTCTTGATAAAGATGATAAAGAAGTAGATCTTCGTGATCTTGATGAAGGCGAAGATGATGATGTTATGCATGTTGATGATCTTGAAAAGGCGCGTGAAAAACAAGCACTTGAAGCTGCTGAATTTGCAAATAGTGATGAGAAATAA","4.90","-46.68","132701","MAGHEVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFKDFLDTGLKEVFEDVLPISNFTDTMELEFVGYELKEPKYTLEEARAHDAHYSAPIFVTFRLINKETGEIKTQEVFFGDFPLMTEMGTFIINGAERIIVSQLVRSPGVYFNDKVDKNGKIGYGSTVIPNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIIDIFGDSELVRNTIEKDIHKNPNDSRTDEALKEIYERLRPGEPKTADSSRSLLIARFFDARRYDLAAVGRYKINKKLNVKTRLLNQVIAENLVDPETGEILVEAGTEMTRSVIDSIADYLDGDLNKIVYTPNEYAVLTEPVVLQKFKVMAPNDPDRTVTVIGNASPDDKVRHLTPADILAEMSYFLNLAEGLGKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNEVLTPQQIINIRPVTAAIKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSYGHLNKYGFIQTPYRKVDRETGKVTNEIEWLTADEEDEFTVAQANSKLNEDGSFAEEIVMGRHQGNNQEFPASSVEYMDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPFVGTGMEYQAAHDSGAAIIAQHNGKVVYSDADKIEVRREDGSLDVYHVTKFRRSNSGTAYNQRTLVRVGDSVEKGDFIADGPSMEKGEMALGQNPVVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEFESETRDTKLGPEEITREIPNVGEDALKDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGGDGVVCDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFDGATSDDLWETVKEAGMDSDAKTVLYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSTITQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDVTGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDKDDKEVDLRDLDEGEDDDVMHVDDLEKAREKQALEAAEFANSDEK","1860688","For other 'rpo' genes see, SMu0086 (rpoE); Smu0746 (rpoD); Smu1817 (rpoA); SMu1806 (rpoC) and SMu0433 (rpoZ).For DNA-directed RNA polymerase, delta subunit see SMu0086. For DNA-directed RNA polymerase, omega subunit see SMu0433. For DNA-directed RNA polymerase, beta' subunit see SMu1806. For DNA-directed RNA polymerase, alpha subunit see SMu1817. From GenBank (gi:1350848): In Spiroplasma citri, DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It catalyzes the reaction: N nucleoside triphosphate = N pyrophosphate + RNA(N). The enzyme consists of the sigma chain and the core enzyme which is composed of 2 alpha chains, 1 beta chain, and 1 beta' chain. It belongs to the RNA polymerase beta chain family. ","DNA-directed RNA polymerase, beta subunit","Cytoplasm","Numerous strong matches in gapped BLAST to DNA-directed RNA polymerase, beta subunit; e.g. residues 1-1171 are 91% similar to DNA-directed RNA polymerase, beta subunit of Streptococcus pneumoniae (gbAAK76028.1); residues 1-1145 are 69% similar to DNA-directed RNA polymerase, beta subunit of Staphylococcus aureus (spP47768).See Spy0098.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0160 (0.0).","

InterPro
IPR007120
Domain

RNA polymerase Rpb2, domain 6
PF00562	$\"[677-1065]T$	RNA_pol_Rpb2_6

InterPro
IPR007121
Family

RNA polymerase, beta subunit
PS01166	$\"[918-930]T$	RNA_POL_BETA

InterPro
IPR007641
Domain

RNA polymerase Rpb2, domain 7
PF04560	$\"[1067-1143]T$	RNA_pol_Rpb2_7

InterPro
IPR007642
Domain

RNA polymerase Rpb2, domain 2
PF04561	$\"[140-328]T$ $\"[378-414]T$	RNA_pol_Rpb2_2

InterPro
IPR007644
Domain

RNA polymerase beta subunit
PF04563	$\"[28-469]T$	RNA_pol_Rpb2_1

InterPro
IPR007645
Domain

RNA polymerase Rpb2, domain 3
PF04565	$\"[473-542]T$	RNA_pol_Rpb2_3

InterPro
IPR010243
Family

DNA-directed RNA polymerase, beta subunit
TIGR02013	$\"[10-1140]T$	rpoB: DNA-directed RNA polymerase, beta sub

noIPR
unintegrated

unintegrated
G3DSA:2.40.270.10	$\"[744-1051]T$	no description
G3DSA:2.40.50.100	$\"[677-741]T$	no description
G3DSA:3.90.1100.10	$\"[12-676]T$	no description
PTHR20856	$\"[449-1162]T$	DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2
PTHR20856:SF3	$\"[449-1162]T$	DNA-DIRECTED RNA POLYMERASE BETA CHAIN

","BeTs to 17 clades of COG0085COG name: DNA-dependent RNA polymerase beta subunit (split gene in Mjan, Mthe, Aful)Functional Class: KThe phylogenetic pattern of COG0085 is AMTkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001572 (RNA polymerases beta subunit) with a combined E-value of 8.2e-219. IPB001572A 403-419 IPB001572B 464-503 IPB001572C 508-532 IPB001572D 624-653 IPB001572E 752-769 IPB001572F 820-844 IPB001572G 918-960 IPB001572H 1032-1085","Residues 380-551 are 81% similar to a (POLYMERASE RNA DNA-DIRECTED BETA) protein domain (PD011517) which is seen in Q9CEN6_LACLA.Residues 213-301 are 37% similar to a (BETA POLYMERASE RNA CHAIN) protein domain (PD017531) which is seen in RPOB_SPICI.Residues 984-1136 are 88% similar to a (POLYMERASE RNA DNA-DIRECTED TRANSFERASE BETA) protein domain (PD000748) which is seen in Q9CEN6_LACLA.Residues 844-923 are 39% similar to a (POLYMERASE RNA DNA-DIRECTED TRANSFERASE) protein domain (PD392212) which is seen in RPOB_CHLVU.Residues 153-205 are 50% similar to a (RNA POLYMERASE BETA DNA-DIRECTED) protein domain (PD383640) which is seen in Q9PA86_XYLFA.Residues 270-378 are 52% similar to a (POLYMERASE RNA BETA DNA-DIRECTED) protein domain (PD039436) which is seen in Q9CEN6_LACLA.Residues 188-254 are 59% similar to a (POLYMERASE RNA BETA DNA-DIRECTED) protein domain (PD383941) which is seen in RPOB_STAAU.Residues 149-187 are 82% similar to a (RNA POLYMERASE BETA DNA-DIRECTED) protein domain (PD415995) which is seen in RPOB_BACHD.Residues 562-747 are 72% similar to a (POLYMERASE RNA BETA DNA-DIRECTED) protein domain (PD001760) which is seen in Q9CEN6_LACLA.Residues 924-979 are 85% similar to a (POLYMERASE RNA DNA-DIRECTED TRANSFERASE TRANSCRIPTION) protein domain (PD000636) which is seen in RPOB_BACSU.Residues 842-889 are 81% similar to a (POLYMERASE RNA BETA DNA-DIRECTED) protein domain (PD105072) which is seen in RPOB_BACHD.Residues 188-269 are 64% similar to a (DNA-DIRECTED RNA POLYMERASE BETA) protein domain (PD404433) which is seen in Q9CEN6_LACLA.Residues 380-467 are 38% similar to a (POLYMERASE RNA DNA-DIRECTED TRANSCRIPTION) protein domain (PD407541) which is seen in RPOB_TOBAC.Residues 331-418 are 35% similar to a (BETA POLYMERASE RNA CHAIN) protein domain (PD331653) which is seen in RPOB_MYCPN.Residues 471-542 are 44% similar to a (RNA POLYMERASE DNA-DIRECTED TRANSCRIPTION) protein domain (PD008835) which is seen in O28393_ARCFU.Residues 230-323 are 35% similar to a (BETA POLYMERASE RNA CHAIN) protein domain (PD127618) which is seen in RPOB_THEMA.Residues 163-269 are 25% similar to a (POLYMERASE RNA DNA-DIRECTED TRANSFERASE) protein domain (PD414892) which is seen in Q9KWU7_THEAQ.Residues 852-923 are 50% similar to a (POLYMERASE RNA DNA-DIRECTED TRANSCRIPTION) protein domain (PD379538) which is seen in Q9XPS7_WHEAT.Residues 748-889 are 73% similar to a (POLYMERASE RNA DNA-DIRECTED BETA TRANSFERASE) protein domain (PD001712) which is seen in RPOB_SYNY3.Residues 738-921 are 24% similar to a (COMPLETE ORF MITOCHONDRION PROTEOME) protein domain (PD000146) which is seen in RPOB_PLAFA.Residues 14-175 are 67% similar to a (POLYMERASE RNA DNA-DIRECTED BETA TRANSFERASE) protein domain (PD001037) which is seen in RPOB_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 27 12:30:02 2006","Tue Jul 11 09:38:25 2006","Fri Feb 17 13:46:28 2006","Thu Mar 28 13:49:06 2002","Tue Jan 15 13:44:53 2002","Tue Jan 15 13:44:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1807 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 15 13:50:28 2002","Fri Feb 17 13:46:28 2006","pdb1HQMC Chain C, Crystal Structure Of Thermus Aquaticus Core... 910 0.0","SMU.1990c","","Residues 28 to 469 (E-value = 2.9e-55) place SMu1807 in the RNA_pol_Rpb2_1 family which is described as RNA polymerase beta subunit (PF04563)Residues 140 to 328 (E-value = 2.5e-08) place SMu1807 in the RNA_pol_Rpb2_2 family which is described as RNA polymerase Rpb2, domain 2 (PF04561)Residues 470 to 542 (E-value = 2e-41) place SMu1807 in the RNA_pol_Rpb2_3 family which is described as RNA polymerase Rpb2, domain 3 (PF04565)Residues 677 to 1065 (E-value = 7.7e-246) place SMu1807 in the RNA_pol_Rpb2_6 family which is described as RNA polymerase Rpb2, domain 6 (PF00562)Residues 1067 to 1143 (E-value = 3.6e-49) place SMu1807 in the RNA_pol_Rpb2_7 family which is described as RNA polymerase Rpb2, domain 7 (PF04560)","Fri Feb 17 13:46:28 2006","","","","Laigret,F., Gaurivaud,P. and Bove,J.M. The unique organization of the rpoB region of Spiroplasma citri: a restriction and modification system gene is adjacent to rpoB. Gene 171 (1): 95-98 (1996) [PubMed: 8675039].Aboshkiwa,M., al-Ani,B., Coleman,G. and Rowland,G. Cloning and physical mapping of the Staphylococcus aureus rplL, rpoB and rpoC genes, encoding ribosomal protein L7/L12 and RNApolymerase subunits beta and beta'. J. Gen. Microbiol. 138 (Pt 9): 1875-1880 (1992) [PubMed: 1402788].Yang,X. and Price,C.W. Streptolydigin resistance can be conferred by alterations to either the beta or beta' subunits of Bacillus subtilis RNA polymerase. J. Biol. Chem. 270 (41): 23930-23933 (1995) [PubMed: 7592585].Boor,K.J., Duncan,M.L. and Price,C.W. Genetic and transcriptional organization of the region encoding the beta subunit of Bacillus subtilis RNA polymerase. J. Biol. Chem. 270 (35): 20329-20336 (1995) [PubMed: 7657605].","","Wed Sep 27 12:30:02 2006","1","","","SMU.1990c","28" "SMu1808","1866850","1864496","2355","ATGTCCCTGCTAAATAAGATAAAAACTAAATTTAAAAGAAATATTAAAAAACCACATTTTAAAAAGATTGATGTAACAAAATTTAATCTTAAAATTTTAAAACGAGCAGATTATCTGGACGTTGCTTCTGTTTTTTTACGAACTTTTAAGTTACTATCTGATTTTGCTTATATTCTTATCCTTTTGATTGCTTTTATGGGAATCGGTATGGGTTTTGGCTATTTGGCAAGCCAAGTTGAGAGTGTTAAAATTCCAAGTAAGGTTAATCTGGTCAATCAAGTTAGTACTTTTACTAGGATTTCTAAAATGACTTACTCAGATAAGTCTATTATTTCAACAATTGATACCGATCTGTTAAGAACACCTATTGAGAGCCGAAATATTTCAGATAATGTAAAAAAAGCTGTCATTGCAACAGAAGATGAAAATTTTAAAACACATAAGGGTGTAGTGCCTAAGGCGGTTTTTCGAGCCACTCTTGCTTCTGTTTTGGGCTTAGGTGAGAATAGCGGCGGTTCTACTTTGACACAGCAATTACTGAAGCAGCAAGTTTTGGGAGACGATCCAACTTTTAAGCGTAAAACCAAGGAAATTATTTATGCTCTTGCCCTTGAACGTTATATTGGTAAGGACAGTATCTTAACCAACTATCTTAATGTATCTCCTTTTGGGCGAAATAACAGGGGGCAAAATATTGCTGGTATTGAAGAAGCTGCTAAAGGGATTTTTGGTGTTGCTGCTAAAGATTTGACAATCCCCCAAGCAGCCTTTTTAGCGGGATTGCCACAGAGTCCAATTACATATTCACCTTATACAGCAGATGGTAAGTTTAAAACTAAGAAGGATATGGAATATGGTTTAAAACGCTCTCAAAATGTTCTTTACAATATGTATCGTACGGGCGTTCTTTCTAAGGTAGACTATGAGAGTTATAAAAAATACGATCTTAGAAAAGATTTTAAGAGACCTCAAGCATCCCAAACAGATTCTCATGATTACTTATACTATTCTGTTTTTGAAGAAGCACAGAAAGTTATGTATGATTATTTAATCAAACGGGACCATGTTTCTTCGCAGGATTTGAAAAATGATAAAACCAAGGCAGCTTACAAGGAAAAAGCTCTACGTGAGATACGTTTAGGTGGCTATACGATTGCTACAACGATTAATAAGATGGTTTATAATGCTATGCAGATGGCAGTAGCTCAGCATGGTGCTTCTCTTGATGATGGAACGGGAAATGTTGAAGTTGGTAATGTTCTTATGGATAATTCGACAGGAGCTATTCTTGGTTTTGTCGGTGGCCGTGATTATAAGAGTAATCAGAATAATCACGCCTTTGATACTGCCAGATCTCCTGGTTCCAGTATTAAGCCTTTATTAGCTTACGGTCCTGCTATTGATCAAGGCTTAATGGGAAGTTCAAGTATGCTTTCCAATTATCCAACAACCTTTTCTAGTGGTCAAAAGATTATGCACGCTGGCGATGAAGGTACGGCCATGGTAAATCTGCAAGAAGCGCTGGATGTTTCTTGGAATATCCCAGCTTATTGGACCTATCAGATGTTGTTGCAAAAAGGTGTTGATGTTCCGGACTATATGGAAAAAATGGGCTATAATATCCCTGAGTACTCTATTGAGAGTCTGCCCTTGGGGGGCGGTGTTGAGACAACAGTAGCTCAACAGACCAATGGTTATCAAACGATTGCTAATGGTGGTGTTTATCAAAAGCAGTACATGATTGATAAAATTACAGATAGCAAGGGGAAAGTCATTTATCAGCATGAGCCTAAACCAGTTCGTGTCTATTCGCAAGCCACTGCCAGCATTTTGAATGATTTGCTTAAAGGACCAATTAGTTCAGGTAAAACAACGACTTTCAAGGATAAATTGAAGGGTCTCAATTCAGATCTTGCAGGAGCTGAATGGACTGGAAAGACAGGAACAACAGATGACTATACAGATGTTTGGTTAATCTTGTCTACTCCTAAAACAACACTTGGTGGTTGGGCTGGCCATGATAACAATGCTTCGTTAGACAAGATGTCAGGTTATAATAACAATGCCCAGTATATGGCATATCTAGTTAATGCCATTAATCAGGCGGATCCAAATATTTTAGGAACAAATCAGCGTTTTAGCCTAGATCCGAGTGTTATCAAAGCAGATGTCTTAAAATCAACCGGTCTCAAACCAGCTACTGTTAATGTCAATGGTAAGAATATTTCTCTTAGTGGTGAGACGACAACCAGCTATTGGGCGAAAAACGGTCCCGGAGATACCGTCTATAAGTTTGCTATAGGCGGTTCAGATAGTGATTATCAAAAAGCTTGGGCCAGCATTGGAGGTAAGTAG","10.10","21.20","86351","MSLLNKIKTKFKRNIKKPHFKKIDVTKFNLKILKRADYLDVASVFLRTFKLLSDFAYILILLIAFMGIGMGFGYLASQVESVKIPSKVNLVNQVSTFTRISKMTYSDKSIISTIDTDLLRTPIESRNISDNVKKAVIATEDENFKTHKGVVPKAVFRATLASVLGLGENSGGSTLTQQLLKQQVLGDDPTFKRKTKEIIYALALERYIGKDSILTNYLNVSPFGRNNRGQNIAGIEEAAKGIFGVAAKDLTIPQAAFLAGLPQSPITYSPYTADGKFKTKKDMEYGLKRSQNVLYNMYRTGVLSKVDYESYKKYDLRKDFKRPQASQTDSHDYLYYSVFEEAQKVMYDYLIKRDHVSSQDLKNDKTKAAYKEKALREIRLGGYTIATTINKMVYNAMQMAVAQHGASLDDGTGNVEVGNVLMDNSTGAILGFVGGRDYKSNQNNHAFDTARSPGSSIKPLLAYGPAIDQGLMGSSSMLSNYPTTFSSGQKIMHAGDEGTAMVNLQEALDVSWNIPAYWTYQMLLQKGVDVPDYMEKMGYNIPEYSIESLPLGGGVETTVAQQTNGYQTIANGGVYQKQYMIDKITDSKGKVIYQHEPKPVRVYSQATASILNDLLKGPISSGKTTTFKDKLKGLNSDLAGAEWTGKTGTTDDYTDVWLILSTPKTTLGGWAGHDNNASLDKMSGYNNNAQYMAYLVNAINQADPNILGTNQRFSLDPSVIKADVLKSTGLKPATVNVNGKNISLSGETTTSYWAKNGPGDTVYKFAIGGSDSDYQKAWASIGGK","1864512","For other 'pbp' genes see SMu0544 (pbp2b); SMu0811 (pbpX); SMu0412 (pbp2X);SMu0424 (pbp1a) and SMu1771 (pbp2a).This protein is similar to PBP-1F from B.subtilis. PBP-1F in involved in cell wall formation. It may be involved in outgrowth of the germinated spore or it could function in the synthesis of the germ cell wall. It is active in the final stages in peptidoglycan synthesis. This membrane-associated protein has expression that remains constant during vegetative growth, decreases during early sporulation, and is induced in the forespore during late sporulation. In the N-terminal section, it belongs to the transglycosylase family. In the C-terminal section, it belongs to the transpeptidase family.Note: The N-terminal 30 amino acids are poorly conserved.","penicillin-binding protein 1b","Extracellular","Numerous strong matches in gapped BLAST to penicillin-binding protein 1b; e.g. residues 34-782 are 67% similar to penicillin-binding protein 1b of Streptococcus pyogenes (gi15674320); residues 34-783 are 58% similar to penicillin-binding protein 1b of Streptococcus pneumoniae (gi15901914).See Spy0097.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0159 (0.0).","

InterPro
IPR001264
Domain

Glycosyl transferase, family 51
PD001895	$\"[190-250]T$	Glyco_trans_51
PF00912	$\"[101-274]T$	Transgly

InterPro
IPR001460
Domain

Penicillin-binding protein, transpeptidase
PF00905	$\"[417-617]T$	Transpeptidase

InterPro
IPR012338
Domain

Penicillin-binding protein, transpeptidase fold
SSF56601	$\"[388-704]T$	PBP_transp_fold

noIPR
unintegrated

unintegrated
G3DSA:3.40.710.10	$\"[396-700]T$	G3DSA:3.40.710.10

","BeTs to 10 clades of COG0744COG name: Membrane carboxypeptidase (penicillin-binding protein)Functional Class: MThe phylogenetic pattern of COG0744 is -----qvCEBRHuj--ol--xNumber of proteins in this genome belonging to this COG is 3","***** IPB001264 (Glycosyltransferase family 51) with a combined E-value of 2.9e-45. IPB001264A 123-162 IPB001264B 171-223 IPB001264C 233-259","Residues 275-424 are 54% similar to a (PENICILLIN-BINDING PROTEOME COMPLETE 1B) protein domain (PD137203) which is seen in O70038_STRPN.Residues 624-781 are 57% similar to a (1B PENICILLIN-BINDING PROTEOME COMPLETE) protein domain (PD137204) which is seen in O70038_STRPN.Residues 107-271 are 65% similar to a (PENICILLIN-BINDING COMPLETE PROTEOME PEPTIDOGLYCAN 1A) protein domain (PD001895) which is seen in O70038_STRPN.Residues 426-539 are 71% similar to a (PENICILLIN-BINDING PROTEOME COMPLETE CELL PEPTIDOGLYCAN) protein domain (PD000435) which is seen in O70038_STRPN.Residues 551-621 are 51% similar to a (PENICILLIN-BINDING COMPLETE PROTEOME 1A) protein domain (PD186125) which is seen in Q9CIH4_LACLA.Residues 426-550 are 66% similar to a (PROTEOME COMPLETE 1B PENICILLIN-BINDING) protein domain (PD396802) which is seen in Q9CIH4_LACLA.Residues 48-160 are 42% similar to a (PROTEOME COMPLETE 1B PENICILLIN-BINDING) protein domain (PD398881) which is seen in Q9CIH4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Mar 16 14:27:20 2007","Tue Jan 15 11:30:19 2002","Fri Feb 17 13:43:05 2006","Wed Apr 3 15:39:21 2002","Tue Jan 15 11:30:19 2002","Tue Jan 15 11:30:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1808 is paralogously related (blast p-value < 1e-3) to SMu1771, a predicted penicillin-binding protein 2a and SMu0424,a predicted penicillin-binding protein 1a.","Mon Apr 15 09:09:28 2002","","No significant hits to the NCBI PDB database.","SMU.1991c","","Residues 101 to 274 (E-value = 1.7e-80) place SMu1808 in the Transgly family which is described as Transglycosylase (PF00912)Residues 417 to 701 (E-value = 4.1e-08) place SMu1808 in the Transpeptidase family which is described as Penicillin binding protein transpeptidase domain (PF00905)","Fri Feb 17 13:43:05 2006","","","Hoskins,J., Matsushima,P., Mullen,D.L., Tang,J., Zhao,G., Meier,T.I., Nicas,T.I. and Jaskunas,S.R. Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae. J. Bacteriol. 181 (20), 6552-6555 (1999) PubMed: 10515951.","","Tue Jan 15 11:30:19 2002","","1","","","SMU.1991c","27" "SMu1809","1867006","1868274","1269","ATGGAGAACTCTATGACTATTTTTGAAGAACTCAAAGCGCGTGGCTTAGTCTTTCAAACCACTGATGAAGAAGCCCTTAAAAAATCATTAGATGACGGACAAGTTTCTTTTTACACAGGTTATGATCCAACAGCAGATAGCCTCCATTTGGGGCATCTCGTACCTATCCTTGTTATGAGGCATTTACAATTGGCTGGACATAAACCTTATGCTCTTGTGGGCGGTGCAACAGGCCTCATCGGCGATCCCTCTTTTAAAGATGATGAACGCAGTCTACAGACTAAAGAAACAGTGAAAAATTGGGTACAAAGCATTCGTAGTCAATTAGAACGTTTCATTGATTTTAAACACGGTGATAACAAGGCTCAGATGGTCAATAACTATGACTGGATGGGAAAGATAACTTTTATTGACTTTCTTCGTGATGTCGGTAAATACTTTACTGTTAATTACATGATGAGTAAAGAATCTGTCAAAAAACGGATTGAAACAGGTATTTCATACACCGAGTTCGCTTACCAGATTATGCAGGGGTATGATTTTTACGTCCTTAATCAAGAACATGCTGTTACACTTCAAGTCGGAGGGTCTGACCAATGGGGAAATATGACTGCAGGAACTGAATTAATTCGTCGAAAAGCTAATAAAACAGCCCATGTCATTACTGTCCCATTAATCACAGATGCAACTGGTAAAAAATTTGGTAAGTCTGAAGGAAATGCTGTCTGGCTTGATGCTGATAAAACATCTCCTTACGAAATGTATCAATTTTGGCTTAATGTCATGGATGCTGATGCCATTCGCTTCCTCAAGATTTTTACTTTCCTATCTCTAGATGAAATCGAAGACATCCGAGTCAAATTTGAAGCAGCACCTCACGAACGTTTAGCTCAAAAAATATTGGCAAAAGAAGTTGTAACTTTTGTTCACGGGCAAACAGCCTATCAAGAAGCTGTCAAAATTACCGAACAACTTTTTGCAGGTCATATCAAGAGCCTCTCTGCAAAAGAACTTAAACAAGGACTTAGTAACGTTCCAAATTATGCTGTTAAGTCCAATGACAATCACAATATCGTTGAATTATTAGTGACGGCTGGCATCGTGAATTCTAAACGTCAGGCGCGTGAAGATCTTCAAAACGGGGCTATTTATATTAATGGGGAACGTATCCAAGATTTAACTTATAACTTATCTCAACAAGATAAAATTGACAATGAACTCACAGTTATTCGTCGTGGTAAGAAAAAATATTTTGTCTTAACTTATTAA","6.90","-0.32","48031","MENSMTIFEELKARGLVFQTTDEEALKKSLDDGQVSFYTGYDPTADSLHLGHLVPILVMRHLQLAGHKPYALVGGATGLIGDPSFKDDERSLQTKETVKNWVQSIRSQLERFIDFKHGDNKAQMVNNYDWMGKITFIDFLRDVGKYFTVNYMMSKESVKKRIETGISYTEFAYQIMQGYDFYVLNQEHAVTLQVGGSDQWGNMTAGTELIRRKANKTAHVITVPLITDATGKKFGKSEGNAVWLDADKTSPYEMYQFWLNVMDADAIRFLKIFTFLSLDEIEDIRVKFEAAPHERLAQKILAKEVVTFVHGQTAYQEAVKITEQLFAGHIKSLSAKELKQGLSNVPNYAVKSNDNHNIVELLVTAGIVNSKRQAREDLQNGAIYINGERIQDLTYNLSQQDKIDNELTVIRRGKKKYFVLTY","1868284","For other 'tyr' genes see SMu0709 (tyrA).From GenBank (gi:135197): In Geobacillus stearothermophilus, TyrS catalyzes the reaction: ATP + L-tyrosine + tRNA(TYR) = AMP + pyrophosphate + L-tyrosyl-tRNA(TYR). This cytoplasmic homodimer belongs to the class-I aminoacyl-tRNA synthetase family.","tyrosyl-tRNA synthetase","Cytoplasm","Numerous strong matches in gapped BLAST to tyrosyl-tRNA synthetase; e.g. residues 5-422 are 82% similar to tyrosyl-tRNA synthetase of Streptococcus pneumoniae (gi15901915); residues 5-422 are 80% similar to tyrosyl-tRNA synthetase of Streptococcus pyogenes (gi15674319).See Spy0096.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0158 (0.0).","

InterPro
IPR000183
Domain

Orn/DAP/Arg decarboxylase 2
PS00878	$\"[348-366]T$	ODR_DC_2_1

InterPro
IPR001412
Family

Aminoacyl-tRNA synthetase, class I
PS00178	$\"[43-53]T$	AA_TRNA_LIGASE_I

InterPro
IPR002305
Domain

Aminoacyl-tRNA synthetase, class Ib
PF00579	$\"[30-327]T$	tRNA-synt_1b

InterPro
IPR002307
Family

Tyrosyl-tRNA synthetase, class Ib
PR01040	$\"[47-69]T$ $\"[165-180]T$ $\"[186-208]T$ $\"[219-231]T$	TRNASYNTHTYR
PTHR11766	$\"[4-422]T$	TYROSYL-TRNA SYNTHETASE
TIGR00234	$\"[2-422]T$	tyrS: tyrosyl-tRNA synthetase

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[356-403]T$	S4
SM00363	$\"[356-418]T$	S4
PS50889	$\"[356-422]T$	S4

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[7-225]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:1.10.240.10	$\"[226-332]T$	no description
G3DSA:3.10.290.10	$\"[343-422]T$	no description

","BeTs to 16 clades of COG0162COG name: Tyrosyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0162 is amtkYqvCeBrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 358-416 are 71% similar to a (SYNTHETASE LIGASE TYROSYL-TRNA) protein domain (PD004483) which is seen in Q9CIH5_LACLA.Residues 168-328 are 79% similar to a (SYNTHETASE LIGASE TYROSYL-TRNA) protein domain (PD131906) which is seen in Q9CIH5_LACLA.Residues 40-167 are 76% similar to a (SYNTHETASE LIGASE TYROSYL-TRNA) protein domain (PD005447) which is seen in Q9CIH5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jul 11 09:32:36 2006","Tue Jul 11 09:32:36 2006","Fri Feb 17 13:39:28 2006","Thu Apr 4 14:35:34 2002","","Tue Jan 15 11:13:51 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1809 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 14:35:34 2002","Fri Feb 17 13:39:28 2006","pdb2TS1 Tyrosyl-Transfer RNA Synthetase (E.C.6.1.1.1) >gi2... 487 9e-139pdb1TYC Tyrosyl-Transfer Rna Synthetase (E.C.6.1.1.1) Muta... 386 2e-108pdb1TYDE Chain E, Tyrosyl-Transfer Rna Synthetase (E.C.6.1.1.... 383 2e-107","SMU.1992","","Residues 30 to 327 (E-value = 5.5e-106) place SMu1809 in the tRNA-synt_1b family which is described as tRNA synthetases class I (W and Y) (PF00579)Residues 356 to 403 (E-value = 1.6e-06) place SMu1809 in the S4 family which is described as S4 domain (PF01479)","Fri Feb 17 13:39:28 2006","24380335","","","Henkin,T.M., Glass,B.L. and Grundy,F.J. Analysis of the Bacillus subtilis tyrS gene: conservation of a regulatory sequence in multiple tRNA synthetase genes. J. Bacteriol. 174 (4): 1299-1306 (1992) [PubMed: 1735721].Waye,M.M. and Winter,G. A transcription terminator in the 5' non-coding region of the tyrosyl tRNA synthetase gene from Bacillus stearothermophilus. Eur. J. Biochem. 158 (3): 505-510 (1986) [PubMed: 3525162].Bhat,T.N., Blow,D.M., Brick,P. and Nyborg,J. Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold. J. Mol. Biol. 158 (4): 699-709 (1982) [PubMed: 7120416].Brick,P., Bhat,T.N. and Blow,D.M. Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. J. Mol. Biol. 208 (1): 83-98 (1989) [PubMed: 2504923].","","Tue Jul 11 09:32:36 2006","1","","","SMU.1992","26" "SMu1810","1869242","1868430","813","ATGTTAAATAGCATTTTAGCTTATGACTTTATGCAACGTGCTTTATTGGCTGTTGTTGCAATCAGTTTTTTTGCACCAATTTTAGGATTATTTTTGATTTTACGTCGTCAGAGTTTAATGAGTGATACCTTGAGTCATGTCTCTTTAGCAGGTGTTGCTTTTGGTGTAGTATTAGGAATTTCTCCCACTTGGACAACTCTTGTAGTCGTCACGTTAGCAGCTGTTATACTTGAATATTTACGGACTGTTTATCGTCATTATATGGAAATTGCGACTGCTATTTTGATGTCACTAGGACTAGCTATATCTTTAATTGTTATGAGCAAAGCTAGGAATACTAGCAATGTCAGTCTTGAACAATATCTTTTTGGTTCTATTATCACCATCAGTCCTGAACAAGTTATTGCCTTATTTATAATTGCGATTATTGTTCTTATTTTGACAATTTGTTTTATCAGACCAATGTATATTTTGACTTTTGATGAAGATACTGCTTTTGTGGATGGTTTGCCAGTTCGTTTAATGTCTGTTTTATTCAATATTGTGACAGGAATTGCTATTTCCCTTACAATTCCGGCAGCAGGAGCTCTTTTAGTATCAACTATTATGGTTTTGCCAGCAAGTATTGCGATGAAATTGGGAAAAAGTTTCAAAACAGTTATTGTTTTAGGGATTCTAATTGGTTTTATTGGCATGGTTTCTGGAATTATTATTTCTTATTTGGCAGAAACACCTGCCAGTGCTACAATTACTTTGATTTTTATTACAATTTTCGTTTTTATTGGATTGATGGATCGATTGGTGAAAGATTGA","8.40","1.42","29213","MLNSILAYDFMQRALLAVVAISFFAPILGLFLILRRQSLMSDTLSHVSLAGVAFGVVLGISPTWTTLVVVTLAAVILEYLRTVYRHYMEIATAILMSLGLAISLIVMSKARNTSNVSLEQYLFGSIITISPEQVIALFIIAIIVLILTICFIRPMYILTFDEDTAFVDGLPVRLMSVLFNIVTGIAISLTIPAAGALLVSTIMVLPASIAMKLGKSFKTVIVLGILIGFIGMVSGIIISYLAETPASATITLIFITIFVFIGLMDRLVKD","1868446","For other components see SMu1811 (NBD1) and SMu1189 (SBP1).For other'adc' genes see SMu1812 (adcR); SMu1811 (adcC) and SMu1189 (adcA). From Medline (98025470): Adc is an ABC-type Zn permease, the first such protein complex identified in any organism. AdcA, together with a set of 14 proteins, including PsaA and homologous adhesins, defines a new family of external solute-binding proteins specific for metals. Investigation of growth of adc and psaA mutants in synthetic medium revealed that the addition of Zn improved the growth rate of the former, whereas the latter exhibited an absolute requirement for added Mn. A psaA-adc double mutant turned out to be essentially non-viable unless both metals were added in the appropriate ratio. Taken together, these results suggest a previously undocumented requirement of S. pneumoniae for Zn and Mn. The addition of Zn also restored near-normal spontaneous transformation of adc mutant cells in standard transformation medium. Zn was found to be specifically required soon after contact of cells with the competence-stimulating peptide, revealing an unsuspected need for Zn in transformation of S. pneumoniae.","zinc ABC transporter, permease","Membrane, Cytoplasm","Many matches in gapped BLAST to zinc ABC transporter, permease protein; e.g. residues 4-269 are 60% similar to ABC transporter membrane-spanning permease - Zinc transport of Streptococcus pneumoniae (gi15904017); residues 5-269 are 54% similar to zinc ABC transporter permease protein of Lactococcus lactis (gi15674095).See Spy0094.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0156 (2e-90).","

InterPro
IPR001626
Family

ABC-3
PF00950	$\"[7-265]T$	ABC-3

noIPR
unintegrated

unintegrated
SSF81345	$\"[2-265]T$	SSF81345

","BeTs to 10 clades of COG1108COG name: ABC-type Mn/Zn transport systems, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1108 is a-tk-QvCeB-H-----LINxNumber of proteins in this genome belonging to this COG is 2","***** IPB001626 (ABC 3 transport family) with a combined E-value of 4.8e-64. IPB001626A 21-67 IPB001626B 74-108 IPB001626C 117-134 IPB001626D 184-229 IPB001626E 230-262","Residues 165-245 are 37% similar to a (MEMBRANE TRANSPORT PROTEOME COMPLETE) protein domain (PD002769) which is seen in O34610_BACSU.Residues 153-248 are 72% similar to a (PROTEOME COMPLETE PERMEASE TRANSMEMBRANE) protein domain (PD401101) which is seen in O33704_STRPN.Residues 29-133 are 69% similar to a (TRANSPORT MEMBRANE TRANSMEMBRANE PROTEOME COMPLETE) protein domain (PD186109) which is seen in O33704_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 5 17:27:38 2006","Tue Sep 5 17:27:38 2006","Fri Feb 17 13:33:29 2006","Tue Apr 9 14:51:14 2002","Tue Jan 15 11:03:03 2002","Tue Jan 15 11:03:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1810 is paralogously related (blast p-value < 1e-3) to SMu0165, a predicted ABC transporter permease element, manganese.","Mon Apr 15 09:10:21 2002","","No significant hits to the NCBI PDB database.","SMU.1993c","","Residues 7 to 265 (E-value = 2.6e-101) place SMu1810 in the ABC-3 family which is described as ABC 3 transport family (PF00950)","Tue Jan 15 11:03:03 2002","","","Dintilhac,A. and Claverys,J.P. The adc locus, which affects competence for genetic transformation in Streptococcus pneumoniae, encodes an ABC transporter with aputative lipoprotein homologous to a family of streptococcal adhesins. Res. Microbiol. 148 (2): 119-131 (1997) [PubMed: 9765793].Dintilhac,A., Alloing,G., Granadel,C. and Claverys,J.P. Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Mol. Microbiol. 25 (4): 727-739 (1997) [PubMed: 9379902].Claverys,J.P., Dintilhac,A., Alloing,G. and Granadel,C. ABC Mn & Zn permeases required for transformation and virulence of Streptococcus pneumoniae. (in) Courvalin,P., Rubens and de Vos,W.M. (Eds.); ASM CONFERENCE ON STREPTOCOCCAL GENETICS. GENETICS OF THE STREPTOCOCCI, ENTEROCOCCI, AND LACTOCOCCI: 29-30;American Society for Microbiology, 1325 Massachusetts Avenue, NW,Washington, DC 20004-4171, USA (1998)","","Tue Jan 15 11:03:03 2002","","1","","","SMU.1993c","241" "SMu1811","1869942","1869232","711","GTGAGATACATTACTGTTGAAAATCTGTCTTATCAGTATGATGCAGAACCTGTTTTGGAAGGAATTAACTATCATTTAGATAGTGGCGAATTTGTAACTTTGACTGGGGAAAACGGAGCTGCAAAGTCAACTTTGATTAAAGCAACTTTGGGTATTCTTAAGCCTAAAATTGGCTCTGTTATTTTTTCTAAAAAAAATGTATCCGGAAAACCATTACGTTTAGCTTATTTGCCCCAGCAAATTGCCAGTTTTAACGCAGGTTTTCCTAGTACGGTCTATGAATTTGTGAAATCAGGACGTTATCCAAGAAATGGTTGGTTTAGAAGACTGACAAAGCATGATGATGAGCATATAAAAGTTAGTCTAGAGTCGGTTGGTATGTGGGAAAATTGCCAAAAACCTATCGGAAGTCTTTCTGGCGGACAAAAACAGCGTGCGGTTATTGCTAGAATGTTTGCTAGTGACCCTGATATTTTTGTCTTGGATGAGCCGACAACGGGAATGGATACAGGAACAACAGAGACCTTTTATAAACTCATGCATCATAGTGCTCATGAGCATGATAAAGCGGTTTTGATGATTACACATGATCCAGAAGAGGTTAAAGCATACGCAGACCGTAATATCCATTTAGTCAGAAATCAAAATCTCCCATGGCGTTGTTTTAATGTTCATGAAAAAGACAGAGAGGAAGAAAATAATGTTAAATAG","7.30","1.32","26766","MRYITVENLSYQYDAEPVLEGINYHLDSGEFVTLTGENGAAKSTLIKATLGILKPKIGSVIFSKKNVSGKPLRLAYLPQQIASFNAGFPSTVYEFVKSGRYPRNGWFRRLTKHDDEHIKVSLESVGMWENCQKPIGSLSGGQKQRAVIARMFASDPDIFVLDEPTTGMDTGTTETFYKLMHHSAHEHDKAVLMITHDPEEVKAYADRNIHLVRNQNLPWRCFNVHEKDREEENNVK","1869248","For other components see SMu1810 (MSD1) and SMu1189 (SBP1). For other'adc' genes see SMu1812 (adcR); SMu1810 (adcB) and SMu1189 (adcA). ","zinc ABC transport, ATP-binding protein","Cytoplasm, Membrane","Many strong matches in gapped BLAST to zinc ABC transporter, ATP-binding protein; e.g. residues 1-232 are 75% similar to ABC transporter (ATP-binding protein) of Streptococcus pyogenes (gi15674316); residues 1-230 are 75% similar to zinc ABC transporter, ATP-binding protein of Streptococcus pneumoniae (gi15901981).See Spy0093.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0155 (1e-106).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[138-180]T$	Q8DS42_STRMU_Q8DS42;
PF00005	$\"[29-215]T$	ABC_tran
PS50893	$\"[4-234]T$	ABC_TRANSPORTER_2
PS00211	$\"[138-152]T$	ABC_TRANSPORTER_1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-216]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-211]T$	no description
PTHR19222	$\"[4-211]T$	ATP BINDING CASSETE (ABC) TRANSPORTER
PTHR19222:SF31	$\"[4-211]T$	METAL ABC TRANSPORTER

","BeTs to 8 clades of COG1121COG name: ABC-type iron (III) transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1121 is a-tk-qvCeB-H-----LINxNumber of proteins in this genome belonging to this COG is 2","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 3.5e-24. IPB001140A 18-64 IPB001140B 135-173","Residues 181-230 are 84% similar to a (PROTEOME BINDING COMPLETE ZINC) protein domain (PD167184) which is seen in O87862_STRPN.Residues 73-133 are 83% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD001985) which is seen in O87862_STRPN.Residues 19-60 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CDU7_LACLA.Residues 138-180 are 60% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O87862_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 13:30:05 2006","Wed Oct 23 15:02:01 2002","Fri Feb 17 13:30:05 2006","Tue Apr 9 14:50:36 2002","Tue Jan 15 10:45:50 2002","Tue Jan 15 10:45:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1811 is paralogously related (blast p-value < 1e-3) to SMu0164, SMu0907, SMu0418, SMu1410, SMu1001, SMu0390, SMu1757, SMu0884, SMu1003, SMu0517, SMu1380, SMu1036, SMu0731, SMu1068, SMu0916, SMu1246, SMu1231, SMu0786, SMu1950, SMu1288, SMu1762, SMu0944, SMu0218, SMu1649, SMu0594, SMu1949, SMu0216, SMu1517, SMu1316, SMu1023, SMu1751, SMu1920, SMu0258, SMu0976, SMu1518, SMu0729, SMu1724, SMu1037, SMu0234, SMu0374, SMu0335, SMu1545, SMu0235, SMu0666, SMu1428, SMu1959, SMu1710, SMu0849, SMu0823, SMu0950, SMu0805, SMu1079, SMu1050, SMu0596, SMu1210, SMu1306, SMu0824, SMu1093, SMu0987, SMu0971, SMu1065, SMu0986, SMu0224, SMu0825, SMu0752, SMu1064, SMu0475, SMu0024, SMu0836, SMu0837, SMu0476, and SMu1686, all having ATP-binding capabilities.","Mon Apr 15 09:11:35 2002","Fri Feb 17 13:30:05 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 64 1e-011","SMU.1994c","","Residues 29 to 215 (E-value = 2.3e-35) place SMu1811 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Jan 15 10:45:50 2002","","","","","","","1","","","SMU.1994c","240" "SMu1812","1870391","1869945","447","ATGACTTTAGGACAGCAAATTGATGCTTTAATCAACCAGATTATCTTAAAAGCTGAAAATCATCATGAACTGTTAATTGGCTCCTGTCAAAGTGATGTTAAATTGACTAATACTCAAGAGCATATTCTCATGTTATTATCACAGGAAAAAAGTCTAACTAATTCTGATTTGGCTAAAGAGTTAAATATTAGTCAAGCTGCTGTGACAAAAGCCGTGAAATCTCTTGTTGGGCAAGAAATGTTAGAATTAATAAAGGATGGAACAGATGCTAGGGTTACTTATTTTCGTCTAACGAAATTGGCGGAACCAGTTGCCAAAGAGCATGAACATCATCATGTTGCAACTTTATCTGTTTATGATCGTATATCACAAAAATTTTCTCAGAAGGAAAAGTCTGTGATTAGTCGCTTTTTAACGGCTTTAACTAAGGAATTAGAAGAGGAATAA","6.40","-2.36","16661","MTLGQQIDALINQIILKAENHHELLIGSCQSDVKLTNTQEHILMLLSQEKSLTNSDLAKELNISQAAVTKAVKSLVGQEMLELIKDGTDARVTYFRLTKLAEPVAKEHEHHHVATLSVYDRISQKFSQKEKSVISRFLTALTKELEEE","1869961","For other'adc' genes see SMu1811 (adcC); SMu1810 (adcB) and SMu1189 (adcA). ","zinc transport transcriptional repressor","Cytoplasm","Four moderate matches in gapped BLAST to zinc transport transcriptional repressor; e.g. residues 3-146 are 59% similar to Transcriptional repressor for Zn(2+)-responsive expression of Streptococcus pneumoniae (gi15904019); residues 1-146 are 52% similar to zinc transport transcriptional regulator of Lactococcus lactis (gi15674098).See Spy0092.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0154 (1e-50).","

InterPro
IPR000835
Family

Bacterial regulatory protein, MarR
PF01047	$\"[35-104]T$	MarR
SM00347	$\"[28-131]T$	HTH_MARR
PS50995	$\"[1-143]T$	HTH_MARR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[15-127]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
SSF46785	$\"[3-148]T$	SSF46785

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 53-144 are 50% similar to a (TRANSCRIPTION DNA-BINDING REGULATION) protein domain (PD001097) which is seen in Q9CDU5_LACLA.Residues 3-49 are 65% similar to a (PROTEOME TRANSCRIPTIONAL REGULATION) protein domain (PD410853) which is seen in O33703_STRPN.Residues 100-146 are 48% similar to a (REGULATION TRANSCRIPTION DNA-BINDING ADCR) protein domain (PD378361) which is seen in O33703_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 13:26:20 2006","Tue Jan 15 10:22:03 2002","Fri Feb 17 13:26:20 2006","Tue Jan 15 10:22:03 2002","","Tue Jan 15 10:22:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1812 is paralogously related (blast p-value < 1e-3) to SMu1591, and SMu0574, both predicted transcriptional regulators.","Mon Apr 15 09:12:38 2002","","No significant hits to the NCBI PDB database.","SMU.1995c","","Residues 35 to 141 (E-value = 1.5e-17) place SMu1812 in the MarR family which is described as MarR family (PF01047)","Tue Jan 15 10:22:03 2002","24380338","","","","","","1","","","SMU.1995c","751" "SMu1813","1871874","1871026","849","ATGGAAATTATTGAAAAAGCTCCGGCTAAAATCAATCTTGGTCTTGATATTGCTGGAAAATATCAAGATGGTTTTCACGAATTGTCAATGATTATGGCCAGTGTTGATTTAAATGATTATTTGACTATTACAGAAATTGCTGAGGATAAGATAGTTGTAGAATCAAATAATTGCAAATTACCTTTAAACCGAAAAAATGATGTTTATAAAGCTGCTCATCTTCTAAAGAGGAGATACCATATCTCAACGGGGCTCAAAATATCTCTTCAAAAAAAGATACCTATATGTGCTGGTTTAGGCGGCGGGTCCAGTGATGCTGCTGCAACTTTACGTGCTCTCAATTGTTTGTGGAAACTCAATTTATCACCAAAAGAACTAATTGATGTTGGTTTTGAAATTGGAAGTGATGTTCCTTATTGCATTGAAGCAGGCTGTGCTTTAATTTCAGGTAAAGGTGAAATTGTAGAACCTTTAGCGACTACTTTGTCAACTTGGGTGGTTTTGGTCAAACCTGATTTTGGAATTTCAACGAAAACAATCTTTAAAGAAATTGATATGGCAACAATTTCTCGAGTTGATATTCCTGCTCTAAAAGAGGCACTTTTAGCAAATTATTATGAGGATGCCTTACAATTTATGGGGAATTCTCTTGAAGATATTACTATTGCTAAAAAACCTTTTATTCAAAAAATAAAAGGCCGTATGATAAAATGTGGTGCGGATATTGCTTTGATGACGGGAAGTGGACCAACCGTTTTTGCTCTCTGTCGAACGGAAAAACGAGCGGATCGTGTTGTTAATAGCATGAAAGGTTTTTGTAAGGAAGTTTATAAAGTTAGAATGTTATAG","8.20","4.35","30951","MEIIEKAPAKINLGLDIAGKYQDGFHELSMIMASVDLNDYLTITEIAEDKIVVESNNCKLPLNRKNDVYKAAHLLKRRYHISTGLKISLQKKIPICAGLGGGSSDAAATLRALNCLWKLNLSPKELIDVGFEIGSDVPYCIEAGCALISGKGEIVEPLATTLSTWVVLVKPDFGISTKTIFKEIDMATISRVDIPALKEALLANYYEDALQFMGNSLEDITIAKKPFIQKIKGRMIKCGADIALMTGSGPTVFALCRTEKRADRVVNSMKGFCKEVYKVRML","1871042","For other 'isp' genes see SMu0529 (ispA).From GenBank (gi:12230281): In Bacillus halodurans, this protein catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2c-methyl-d-erythritol. It is involved in the deoxyxylulose-5-phosphate pathway (dxp) of soprenoid biosynthesis; fourth step. This protein belongs to the IspE family. ","isopentenyl monophosphate kinase (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase)","Cytoplasm","Many strong matches in gapped BLAST to isopentenyl monophosphate kinase; residues 1-282 are 41% similar to 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase of Bacillus subtilis (gi16077114); residues 6-282 are 40% similar to isopentenyl monophosphate kinase of Bacillus halodurans (gi15612624).See Spy0088 and Spy0091.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0153 (1e-100).","

InterPro
IPR000870
Family

Homoserine kinase
PR00958	$\"[7-22]T$ $\"[100-115]T$ $\"[168-185]T$ $\"[240-255]T$	HOMSERKINASE

InterPro
IPR004424
Family

4-diphosphocytidyl-2C-methyl-D-erythritol kinase
PIRSF010376	$\"[6-282]T$	IspE
PTHR20861:SF2	$\"[48-281]T$	IspE
TIGR00154	$\"[1-282]T$	ispE

InterPro
IPR006204
Domain

GHMP kinase
PF00288	$\"[86-144]T$	GHMP_kinases_N

InterPro
IPR013750
Domain

GHMP kinase, C-terminal
PF08544	$\"[193-275]T$	GHMP_kinases_C

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[3-160]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
PTHR20861	$\"[48-281]T$	PTHR20861
SSF54211	$\"[1-158]T$	SSF54211
SSF55060	$\"[161-281]T$	SSF55060

","BeTs to 9 clades of COG1947COG name: Uncharacterized ACR, YchB/YabH familyFunctional Class: SThe phylogenetic pattern of COG1947 is -----qvcebrhuj---li--Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 7-139 are 45% similar to a (KINASE TRANSFERASE ATP-BINDING) protein domain (PD008614) which is seen in ISPE_BACSU.Residues 141-255 are 35% similar to a (KINASE ATP-BINDING TRANSFERASE CMK) protein domain (PD338721) which is seen in ISPE_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 13:24:10 2006","Fri Jan 11 16:09:45 2002","Fri Feb 17 13:24:10 2006","Fri Jan 11 16:09:45 2002","","Fri Jan 11 16:09:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1813 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 16:49:25 2002","","No significant hits to the NCBI PDB database.","SMU.1996c","","Residues 84 to 260 (E-value = 1.9e-25) place SMu1813 in the GHMP_kinases family which is described as GHMP kinases putative ATP-binding protein (PF00288)","Fri Jan 11 16:09:45 2002","","","","","","","1","","","SMU.1996c","" "SMu1814","1872503","1872021","483","ATGGAAGAAGATTTTGAAATTGTTTTTAATAAGGTTAAGCCAATTGTATGGAAATTAAGCCGTTATTACTTTATTAAAATGTGGACTCGTGAAGATTGGCAACAAGAGGGAATGTTGATTTTGCACCAATTATTAAGGGAACATCCAGAATTAGAAGAGGATGATACAAAATTGTATATCTATTTTAAGACACGTTTTTCTAATTACATTAAAGATGTTTTGCGTCAGCAAGAAAGTCAGAAACGTCGTTTTAATAGAATGTCTTATGAAGAAGTCGGTGAGATTGAACACTGTTTGTCAAGTGGCGGTATGCAATTGGATGAATATATTTTATTTCGTGATAGTTTGCTTGCATATAAACAAGGTCTGAGTACTGAAAAGCAAGAGCTGTTTGAGCGCTTGGTAGCAGGAGAGCACTTTTTGGGAAGGCAAAGTATGCTGAAAGATTTACGTAAAAAATTAAGTGATTTTAAGGAAAAATAG","6.50","-1.07","19590","MEEDFEIVFNKVKPIVWKLSRYYFIKMWTREDWQQEGMLILHQLLREHPELEEDDTKLYIYFKTRFSNYIKDVLRQQESQKRRFNRMSYEEVGEIEHCLSSGGMQLDEYILFRDSLLAYKQGLSTEKQELFERLVAGEHFLGRQSMLKDLRKKLSDFKEK","1872037","For other 'com' genes see SMu0567 (comEA); SMu0568 (comEC); SMu0138 (comR);SMu0258 (comA); SMu0259 (comB);SMu1804 (comYA);SMu1803 (comYB); SMu1802 (comYC);SMu1801 (comYD); SMu0451 (comF); SMu0452 (comFC); SMu0490 (comC); SMu1782 (comA);SMu1684 (comEB);SMu1710 (comA); SMu1739 (comC) and SMu1740 (comD). ","competence-specific sigma factor","Cytoplasm","Few moderate matches in gapped BLAST to competence-specific global transcription modulator; residues 1-160 are 43% similar to competence protein of Streptococcus pyogenes (gi15674470); residues 8-157 are 46% similar to transcriptional regulator ComX1 of Streptococcus pneumoniae (gi15899963).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0091 (1e-39).","

InterPro
IPR013325
Domain

RNA polymerase sigma factor, region 2
SSF88946	$\"[2-97]T$	Sigma_r2

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 18-144 are 48% similar to a (PROTEOME COMPLETE REGULATOR COMPETENCE) protein domain (PD303084) which is seen in Q9R2W8_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 08:38:04 2006","Thu Sep 7 08:36:10 2006","Thu Feb 3 15:06:44 2005","Fri Jan 11 16:01:46 2002","","Fri Jan 11 16:01:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1814 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 10:02:40 2002","","No significant hits to the NCBI PDB database.","SMU.1997c","","No significant hits to the Pfam 11.0 database","Fri Jan 11 16:01:46 2002","","","Aspiras MB, Ellen RP, Cvitkovitch DG.ComX activity of Streptococcus mutans growing in biofilms.FEMS Microbiol Lett. 2004 Sep;238(1):167-74.PMID: 15336418","","Thu Sep 7 08:36:10 2006","","1","","","SMU.1997c","879" "SMu1815","1879807","1878521","1287","ATGGCTAAAGCAGTAGACTTATTAAAAAAGCGCTATCTTGATAATATTCAAGATAAACCAGAGTCTTATATAGGAGTTGAATTAGAGTTTCCAATAGTTAATTTAAGCCATCAGGCAACTGATATAACAGTAACAAAATCTGTAATGTTTCATCTTAAGGAATCTCTATTTTTTGAAGTGGAAAGATATGATCAGGATGGTTGCCCTGTGCAATTGATTGATAGAAAATCAGAGGATAGAATTCTTTTTGAAGTTTCTTATAATACAATAGAATTTGCTTTTGGGAAAGCAAAAAAGATTCAGGATATTGAAGAACGCTTTAATCAATATATGAAAGTCATACAAGCCTTTCTCAAACCTTACAACCATGCTATACAGGGATTTGGAGTGCATCCTTATTGGTATTTAAATGATAATAGAGCTGTTAAATTACCTCGTTATCAAATGCTTTTAAATTTCTTGGCTTTATCGGGAAATAAAAAAGATTCTTTTTTTCATGGTTTTCCTCAATACGGTTCTTTTATTTGTGGCAATCAAGTACAATTAGATGTCAGCAAGAGCAATTATTTAAGAGTTATCAACGCTTTTAATAAGATTGAAGCTGTGAAAGCTTACCTTTTTGCTAACTCAGAATTTTGGGGACAAAATTGGTCAACTAAAATTTCACGAGATATTTTTTGGGAAAATTCTATGCATGGGGTTTTTGAAGAGAATGTCGGTGTTAATAAGATATCTTTTGAAACAGAAGAAGATTTTTTTAATTATCTTGCCAATTCAGCTCTTTTTACAGCCGAAAGAGAAACAGAAATCCTCTATTTTGAACCCATTCGTGTAAAAGATTATTTGGGACAGGAAGAAATCTCAGCTTGGGATTTAAGTGGTCAACAGCACTATATTCTTCCAGATGAGGCAGATTTTGCTAATCATAGAAGCTATCAATATCAAAATTTAACAAAACGGGGGACTGTTGAGTTTAGAAGCGTCTGCACGCAACCACTGGAGAAAACCTTTGTTCCTATTGCTTTTCACGTTGGGCTTTTGGAGAACTTAGATGAATTAGAGAAGCTTCTTGAAAAAAGTGATTTTCTGCAATTTTATAATCATGATTATAAATTCATCAGACGGCAATTCTCGCAAAAAGTTATCACTCAAGAAGCCAAGAGGTTCATCAGTGTATTTTCGGAGGCAGTGCTAGAGTGTTGCGAAAGGGGACTAAAAAGGCGTGGTTTGGGGGAAGAGAGGTATATAAAGGAAATAAAACAGAAAAAAAGCGAGAAAAGCTATTGA","6.40","-3.78","50455","MAKAVDLLKKRYLDNIQDKPESYIGVELEFPIVNLSHQATDITVTKSVMFHLKESLFFEVERYDQDGCPVQLIDRKSEDRILFEVSYNTIEFAFGKAKKIQDIEERFNQYMKVIQAFLKPYNHAIQGFGVHPYWYLNDNRAVKLPRYQMLLNFLALSGNKKDSFFHGFPQYGSFICGNQVQLDVSKSNYLRVINAFNKIEAVKAYLFANSEFWGQNWSTKISRDIFWENSMHGVFEENVGVNKISFETEEDFFNYLANSALFTAERETEILYFEPIRVKDYLGQEEISAWDLSGQQHYILPDEADFANHRSYQYQNLTKRGTVEFRSVCTQPLEKTFVPIAFHVGLLENLDELEKLLEKSDFLQFYNHDYKFIRRQFSQKVITQEAKRFISVFSEAVLECCERGLKRRGLGEERYIKEIKQKKSEKSY","1878537","","glutamate--cysteine ligase","Cytoplasm","Some strong matches in gapped BLAST to conserved hypothetical proteins; residues 398 are 55% similar to hypothetical protein of Streptococcus pneumoniae (gi15903920).SMu1815 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
SSF55931	$\"[13-403]T$	SSF55931

InterPro
IPR000456
Family

Ribosomal protein L17
PD004277	$\"[18-124]T$	Ribosomal_L17
PTHR14413	$\"[1-67]T$ $\"[84-128]T$	Ribosomal_L17
PF01196	$\"[16-128]T$	Ribosomal_L17
TIGR00059	$\"[2-128]T$	L17
PS01167	$\"[30-52]T$	RIBOSOMAL_L17

noIPR
unintegrated

unintegrated
G3DSA:3.90.1030.10	$\"[1-128]T$	G3DSA:3.90.1030.10
SSF64263	$\"[10-128]T$	SSF64263

","BeTs to 13 clades of COG0203COG name: Ribosomal protein L17Functional Class: JThe phylogenetic pattern of COG0203 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000456 (Ribosomal protein L17) with a combined E-value of 1.6e-54. IPB000456A 15-58 IPB000456B 75-128","Residues 87-127 are 82% similar to a (RIBOSOMAL 50S PROTEOME COMPLETE) protein domain (PD249232) which is seen in Q9CDY4_LACLA.Residues 4-59 are 85% similar to a (RIBOSOMAL 50S PROTEOME COMPLETE) protein domain (PD004277) which is seen in Q9CDY4_LACLA.Residues 5-66 are 51% similar to a (RIBOSOMAL 50S CHLOROPLAST PROTEOME) protein domain (PD389410) which is seen in RL17_SYNP6.Residues 88-128 are 63% similar to a (RIBOSOMAL 50S PROTEOME COMPLETE) protein domain (PD408674) which is seen in RM08_YEAST.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 13:13:58 2006","Fri Jan 11 15:51:07 2002","Fri Feb 17 13:13:58 2006","Fri Jan 11 15:51:07 2002","Fri Jan 11 15:51:07 2002","Fri Jan 11 15:51:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1816 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:11:49 2002","","No significant hits to the NCBI PDB database.","SMU.2000c","","Residues 16 to 128 (E-value = 4.3e-62) place SMu1816 in the Ribosomal_L17 family which is described as Ribosomal protein L17 (PF01196)","Fri Jan 11 15:51:07 2002","","","","Boylan,S.A., Suh,J.W., Thomas,S.M. and Price,C.W. Gene encoding the alpha core subunit of Bacillus subtilis RNA polymerase is cotranscribed with the genes for initiation factor 1and ribosomal proteins B, S13, S11, and L17. J. Bacteriol. 171 (5): 2553-2562 (1989) [PubMed: 2496109].","","Fri Jan 11 15:51:07 2002","1","","","SMU.2000c","617" "SMu1817","1881376","1880438","939","ATGATTGAGTTTGAAAAACCAATAATAACAAAAATTGATGAAAATAAAGATTACGGCAGATTTGTCATTGAACCACTTGAACGTGGCTATGGTACAACTCTAGGGAATTCCCTTCGTCGTGTGCTGTTGTCTTCACTTCCGGGTGCAGCTGTTACATCAATTAAGATTGATGGAGTACTACACGAATTTGATACTATCCCAGGTGTACGCGAGGATGTTATGCAAATCATCCTTAATATAAAAGGACTTGCTGTAAAATCTTATGTCGAAGAAGAAAAGATTGTTGAATTAGATGTTGAAGGACCTGCAGAAATTACTGCTGGAGATATTTTAACAGACAGTGATATTGAAATAGTTAATCCTGATCATTATCTCTTTACTATTGCTGAAGGTGCTAATTTAAAAGCAACCATGACTGTTGCAACTAATCGTGGTTATGTTCCAGCAGAGAAAAATAAAAGAGATGATGCACCAGTTGGGACGCTCGCGATAGATTCTATCTATACGCCAGTTAAAAAAGTTAATTATCAAGTTGAGCCAGCTCGTGTGGGCAGCAATGATAACTTTGATAAATTAACAATTGAAATTATGACCAATGGCACAATTATTCCTGAGGATGCTCTTGGGTTATCTGCTCGTGTTTTGATTGAGCATTTAAATCTTTTTACTGATTTAACCGAGGTAGCCAAGGCGACTGATGTCATGAAAGAAACAGAACAAGTTTCTGATGAGAAAGTACTTGATCGTACGATTGAGGAACTTGATTTATCAGTGCGTTCTTATAACTGTCTTAAACGCGCTGGTATTAATACAGTCTATGATTTAACTGAAAAGTCTGAATCTGAAATGATGAAAGTTAGAAATCTTGGACGTAAAAGTCTTGAAGAAGTTAAAGTAAAGCTTGCAGATCTTGGTTTAGGCTTGAAAAATGATAAATAA","4.60","-16.28","34557","MIEFEKPIITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLSSLPGAAVTSIKIDGVLHEFDTIPGVREDVMQIILNIKGLAVKSYVEEEKIVELDVEGPAEITAGDILTDSDIEIVNPDHYLFTIAEGANLKATMTVATNRGYVPAEKNKRDDAPVGTLAIDSIYTPVKKVNYQVEPARVGSNDNFDKLTIEIMTNGTIIPEDALGLSARVLIEHLNLFTDLTEVAKATDVMKETEQVSDEKVLDRTIEELDLSVRSYNCLKRAGINTVYDLTEKSESEMMKVRNLGRKSLEEVKVKLADLGLGLKNDK","1880454","For other 'rpo' genes see, SMu0086 (rpoE); Smu0746 (rpoD); Smu1807 (rpoB); SMu1806 (rpoC) and SMu0433 (rpoZ).For DNA-directed RNA polymerase, delta subunit see SMu0086. For DNA-directed RNA polymerase, omega subunit see SMu0433. For DNA-directed RNA polymerase, beta subunit see SMu1807. For DNA-directed RNA polymerase, beta' subunit see SMu1806. From GenBank (gi:13878751): In Lactococcus lactis, DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It catalyzes the reaction: N nucleoside triphosphate = N pyrophosphate + RNA(N). This protein consists of a sigma factor and the RNAP core enzyme which is composed of 2 alpha chains, 1 beta chain, 1 beta' chain and 1 omega chain. The amino-terminal portion is involved in the assembly of core RNAP, whereas the C-terminal is involved in interaction with transcriptional regulators. It belongs to the RNA polymerase alpha chain family.","DNA-directed RNA polymerase, alpha subunit","Cytoplasm","Numerous strong matches in gapped BLAST to DNA-directed RNA polymerase, alpha subunit; residues 1-312 are 93% similar to DNA-directed RNA polymerase, alpha subunit of Streptococcus pyogenes (gi15674313); residues 1-310 are 86% similar to DNA-directed RNA polymerase, alpha subunit of Streptococcus pneumoniae (gi15900172).See Spy0080.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0084 (1e-167).","

InterPro
IPR009025
Domain

RNA polymerase, RBP11-like
SSF55257	$\"[4-226]T$	RNAP_RBP11-like

InterPro
IPR011260
Domain

RNA polymerase, alpha subunit, C-terminal
PD001179	$\"[251-309]T$	RNAP_alpha_C
PF03118	$\"[236-303]T$	RNA_pol_A_CTD

InterPro
IPR011261
Domain

RNA polymerase, dimerisation
PF01193	$\"[14-224]T$	RNA_pol_L

InterPro
IPR011262
Domain

RNA polymerase, insert
G3DSA:2.170.120.12	$\"[48-168]T$	RNAP_insert
PF01000	$\"[54-169]T$	RNA_pol_A_bac
SSF56553	$\"[48-169]T$	RNAP_insert

InterPro
IPR011263
Domain

RNA polymerase, RpoA/D/Rpb3-type
SM00662	$\"[18-225]T$	RPOLD

InterPro
IPR011773
Family

DNA-directed RNA polymerase, alpha subunit
TIGR02027	$\"[18-311]T$	rpoA

noIPR
unintegrated

unintegrated
G3DSA:1.10.150.20	$\"[240-311]T$	G3DSA:1.10.150.20
SSF47789	$\"[243-309]T$	SSF47789

","BeTs to 13 clades of COG0202COG name: DNA-dependent RNA polymerase alpha subunitFunctional Class: KThe phylogenetic pattern of COG0202 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001700 (Bacterial RNA polymerase, alpha chain) with a combined E-value of 1.6e-94. IPB001700A 18-62 IPB001700B 125-141 IPB001700C 164-178 IPB001700D 190-222 IPB001700E 251-293","Residues 3-301 are 69% similar to a (RNA POLYMERASE ALPHA DNA-DIRECTED) protein domain (PD001179) which is seen in RPOA_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Sep 1 18:05:55 2006","Fri Jan 11 15:42:00 2002","Fri Feb 17 13:09:26 2006","Fri Jan 11 15:42:00 2002","Fri Jan 11 15:42:00 2002","Fri Jan 11 15:42:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1817 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 13:38:19 2002","Fri Feb 17 13:09:26 2006","pdb1HQMA Chain A, Crystal Structure Of Thermus Aquaticus Core... 241 1e-064pdb1BDFB Chain B, Structure Of Escherichia Coli Rna Polymeras... 207 2e-054pdb1COO The Cooh-Terminal Domain Of Rna Polymerase Alpha S... 63 4e-011","SMU.2001c","","Residues 14 to 224 (E-value = 2e-21) place SMu1817 in the RNA_pol_L family which is described as RNA polymerase Rpb3/Rpb11 dimerisation domain (PF01193)Residues 54 to 169 (E-value = 2.4e-58) place SMu1817 in the RNA_pol_A_bac family which is described as RNA polymerase Rpb3/RpoA insert domain (PF01000)Residues 236 to 303 (E-value = 1.5e-31) place SMu1817 in the RNA_pol_A_CTD family which is described as Bacterial RNA polymerase, alpha chain C terminal domain (PF03118)","Fri Feb 17 13:09:26 2006","","","","Nakasone,K., Takaki,Y., Takami,H., Inoue,A. and Horikoshi,K. Cloning and expression of the gene encoding RNA polymerase alpha subunit from alkaliphilic Bacillus sp. strain C-125. FEMS Microbiol. Lett. 168 (2): 269-276 (1998) [PubMed: 9835038].","","Fri Jan 11 15:42:00 2002","1","","","SMU.2001c","227" "SMu1818","1881805","1881422","384","TTGGCTAAACCAACACGTAAACGTCGTGTCAAGAAAAATATTGAATCTGGTATTGCCCATATTCACGCAACATTTAATAACACTATTGTTATGATTACAGATGTGCATGGTAACGCTCTTGCATGGTCATCAGCTGGTGCTCTTGGATTCAAAGGTTCACGTAAATCTACTCCATTTGCTGCTCAAATGGCTGCAGAAGCCGCTGCTAAGTCTGCACAAGAACACGGTCTTAAAACAGTTGAAGTTACTGTAAAAGGTCCAGGTTCAGGTCGTGAGTCTGCTATTCGTGCGCTTGCCGCTGCTGGTCTTGAAGTAACGTCAATTCGTGATGTGACTCCTGTACCACATAATGGTGCTCGTCCTCCAAAACGTCGTCGTGTATAA","12.00","14.19","13365","MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNALAWSSAGALGFKGSRKSTPFAAQMAAEAAAKSAQEHGLKTVEVTVKGPGSGRESAIRALAAAGLEVTSIRDVTPVPHNGARPPKRRRV","1881438","For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1828 (rs8); SMu1819 (rs13) SMu1819 (rs13); SMu1819 (rs13); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:133719): In Bacillus subtilis, S11 plays an essential role for the selection of the correct tRNA in protein biosynthesis. It is located on the large lobe of the small subunit and belongs to the S11P family of ribosomal proteins. ","30S ribosomal protein S11","Cytoplasm, Extracellular","Many strong matches in gapped BLAST to 30S ribosomal protein S11; residues 1-127 are 86% similar to 30S ribosomal protein S11 of Streptococcus pneumoniae (gi15900171); residues 1-127 are 86% similar to 30S ribosomal protein S11 of Streptococcus pyogenes(gi15674312).See Spy0078.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0083 (5e-56).","

InterPro
IPR001971
Family

Ribosomal protein S11
PD001010	$\"[18-91]T$	RS11_STRMU_P59378;
G3DSA:3.30.420.80	$\"[1-126]T$	no description
PTHR11759	$\"[7-127]T$	40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11
PF00411	$\"[17-126]T$	Ribosomal_S11
PS00054	$\"[95-117]T$	RIBOSOMAL_S11

noIPR
unintegrated

unintegrated
PTHR11759:SF3	$\"[7-127]T$	30S RIBOSOMAL PROTEIN S11

","BeTs to 17 clades of COG0100COG name: Ribosomal protein S11Functional Class: JThe phylogenetic pattern of COG0100 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001971 (Ribosomal protein S11) with a combined E-value of 1.9e-68. IPB001971A 19-65 IPB001971B 85-126","Residues 20-127 are 42% similar to a (RIBOSOMAL S11 MITOCHONDRION MITOCHONDRIAL) protein domain (PD082002) which is seen in Q9DCA2_MOUSE.Residues 20-127 are 33% similar to a (RIBOSOMAL NUCLEAR ENCODED S11) protein domain (PD083079) which is seen in P93408_ORYSA.Residues 5-29 are 92% similar to a (RIBOSOMAL 30S BS11) protein domain (PD333712) which is seen in RS11_BACSU.Residues 5-29 are 88% similar to a (RIBOSOMAL PROTEOME COMPLETE S11) protein domain (PD368025) which is seen in Q9CDY2_LACLA.Residues 32-123 are 80% similar to a (RIBOSOMAL 30S CHLOROPLAST 40S COMPLETE PROTEOME S11P) protein domain (PD001010) which is seen in Q9CDY2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 13:05:22 2006","Fri Jan 11 15:34:28 2002","Fri Feb 17 13:05:22 2006","Fri Jan 11 15:34:28 2002","Fri Jan 11 15:34:28 2002","Fri Jan 11 15:34:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1818 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:30:20 2002","Fri Feb 17 13:05:22 2006","pdb1FJFK Chain K, Structure Of The Thermus Thermophilus 30s R... 139 1e-034","SMU.2002c","","Residues 17 to 126 (E-value = 2.2e-72) place SMu1818 in the Ribosomal_S11 family which is described as Ribosomal protein S11 (PF00411)","Fri Jan 11 15:34:28 2002","","","","Boylan,S.A., Suh,J.W., Thomas,S.M. and Price,C.W. Gene encoding the alpha core subunit of Bacillus subtilis RNA polymerase is cotranscribed with the genes for initiation factor 1and ribosomal proteins B, S13, S11, and L17. J. Bacteriol. 171 (5): 2553-2562 (1989) [PubMed: 2496109].","","Fri Jan 11 15:34:28 2002","1","","","SMU.2002c","616" "SMu1819","1882188","1881823","366","ATGGCTCGTATTGCTGGAGTTGATATTCCAAATGACAAACGTGTAGTCGTATCACTTACTTATGTATATGGTATCGGTTTGCCAACTTCTAAAAAAATTCTTGCAGCAGCAGGTGTTTCTGAGGATATCCGTGTCAAAGATTTAACATCTGATCAAGAAGATGCTATTCGTCGTGAAGTTGATGCAATCAAGGTTGAAGGAGATCTTCGTCGTGAAGTTAACTTGAATATTAAACGGTTGATGGAAATTGGTTCATATCGCGGAATCCGTCATCGTCGTGGACTTCCTGTCCGTGGACAAAATACCAAAAACAATGCTCGCACTCGCAAGGGTAAAGCTGTAGCGATTGCAGGTAAGAAAAAATAA","11.30","13.23","13389","MARIAGVDIPNDKRVVVSLTYVYGIGLPTSKKILAAAGVSEDIRVKDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK","1881839","For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1828 (rs8); SMu1819 (rs13) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:13432228): In Lactococcus lactis, the full ribosomal protein is involved in the binding of fMet-tRNA and, hence, in the initiation of translation. It belongs to the S13P family of ribosomal proteins. ","30S ribosomal protein S13, N-terminal fragment","Cytoplasm","Many strong matches in gapped BLAST to large N-terminal fragments of the 30S ribosomal protein S13; residues 1-109 are 96% similar to 30S ribosomal protein S13 of Streptococcus pyogenes (gi15674311); residues 1-109 are 95% similar to 30S ribosomal protein S13 of Streptococcus pneumoniae (gi15900170).See Spy0077.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0082 (1e-55).","

InterPro
IPR001892
Family

Ribosomal protein S13
PD001363	$\"[44-109]T$	Ribosomal_S13
PTHR10871:SF1	$\"[1-120]T$	Ribosomal_S13
PF00416	$\"[3-108]T$	Ribosomal_S13
PS00646	$\"[87-100]T$	RIBOSOMAL_S13_1
PS50159	$\"[4-111]T$	RIBOSOMAL_S13_2

InterPro
IPR010979
Domain

Ribosomal protein S13-like, H2TH
SSF46946	$\"[2-120]T$	Ribosomal_H2TH

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.50	$\"[1-71]T$	G3DSA:1.10.8.50
G3DSA:4.10.910.10	$\"[72-121]T$	G3DSA:4.10.910.10
PTHR10871	$\"[1-120]T$	PTHR10871

","BeTs to 17 clades of COG0099COG name: Ribosomal protein S13Functional Class: JThe phylogenetic pattern of COG0099 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001892 (Ribosomal protein S13) with a combined E-value of 4.6e-43. IPB001892A 3-26 IPB001892B 76-108","Residues 3-108 are 84% similar to a (RIBOSOMAL 30S MITOCHONDRION PROTEOME MITOCHONDRIAL) protein domain (PD001363) which is seen in RS13_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 24 11:28:50 2006","Fri Jan 11 15:29:16 2002","Fri Feb 17 13:01:34 2006","Fri Jan 11 15:29:16 2002","Fri Jan 11 15:29:16 2002","Fri Jan 11 15:29:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1819 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:29:21 2002","Fri Feb 17 13:01:34 2006","pdb1FJFM Chain M, Structure Of The Thermus Thermophilus 30s R... 128 3e-031","SMU.2003c","","Residues 3 to 108 (E-value = 1.1e-55) place SMu1819 in the Ribosomal_S13 family which is described as Ribosomal protein S13/S18 (PF00416)","Fri Jan 11 15:29:16 2002","","","","Koivula,T. and Hemila,H. Nucleotide sequence of a Lactococcus lactis gene cluster encoding adenylate kinase, initiation factor 1 and ribosomal proteins. J. Gen. Microbiol. 137 (Pt 11): 2595-2600 (1991) [PubMed: ].","","Fri Jan 11 15:29:16 2002","1","","","SMU.2003c","615" "SMu1820","1882568","1882350","219","GTGGCAAAAGAAGATGTGATTGAAATTGAAGGTAAAGTTGTCGAAACAATGCCAAATGCAATGTTTACAGTTGAATTGGAAAATGGACACCAAATTTTGGCAACCGTATCTGGAAAAATTCGGAAAAACTATATTCGTATTTTAGTAGGAGATAAGGTTACTGTCGAAATGAGTCCGTATGATTTAACACGTGGACGTATCACATACCGCTTTAAATAA","9.20","1.23","8195","MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDKVTVEMSPYDLTRGRITYRFK","1882366","From GenBank (gi:124195): In Lactococcus lactis, no specific function has so far been attributed to this initiation factor; however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3. This cytoplasmic protein belongs to the IF-1 family and contains 1 'S1 motif' domain. ","translation initiation factor IF-1","Cytoplasm","Many moderate matches in gapped BLAST to translation initiation factor IF-1; residues 1-72 are 97% similar to translation initiation factor IF-1 of Streptococcus pyogenes (gi15674309); residues 1-72 are 93% similar to translation initiation factor IF-1 of Streptococcus pneumoniae (gi15902255).See Spy0075.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0080 (2e-36).","

InterPro
IPR003029
Domain

RNA binding S1
SM00316	$\"[4-72]T$	S1

InterPro
IPR004368
Family

Translation initiation factor IF-1
TIGR00008	$\"[3-71]T$	infA: translation initiation factor IF-1

InterPro
IPR006196
Family

S1, IF1 type
PF01176	$\"[5-70]T$	eIF-1a
PS50832	$\"[1-72]T$	S1_IF1_TYPE

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[1-71]T$	no description

","BeTs to 14 clades of COG0361COG name: Translation initiation factor IF-1Functional Class: JThe phylogenetic pattern of COG0361 is amtkyqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003029 (S1 RNA binding domain) with a combined E-value of 6.1e-06. IPB003029A 11-22 IPB003029B 50-61","Residues 3-70 are 57% similar to a (FACTOR INITIATION IF-1 BIOSYNTHESIS) protein domain (PD026322) which is seen in IF1_CHLTR.Residues 3-39 are 78% similar to a (FACTOR INITIATION TRANSLATION IF-1) protein domain (PD003775) which is seen in IF1_BACHD.Residues 40-70 are 90% similar to a (INITIATION FACTOR TRANSLATION IF-1) protein domain (PD003406) which is seen in IF1_LACLA.Residues 2-39 are 84% similar to a (FACTOR INITIATION IF-1 BIOSYNTHESIS) protein domain (PD351538) which is seen in IF1_LACLA.Residues 40-72 are 72% similar to a (FACTOR INITIATION IF-1 BIOSYNTHESIS) protein domain (PD370864) which is seen in IF1C_SPIMX.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 14:48:13 2006","Fri Jan 11 14:57:16 2002","Fri Feb 17 12:42:43 2006","Fri Jan 11 14:57:16 2002","Fri Jan 11 14:57:16 2002","Fri Jan 11 14:57:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1820 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 15:18:47 2002","Fri Feb 17 12:42:43 2006","pdb1AH9 The Structure Of The Translational Initiation Fact... 106 6e-025pdb1HR0W Chain W, Crystal Structure Of Initiation Factor If1 ... 86 7e-019","SMU.2004c","","Residues 2 to 72 (E-value = 5.3e-13) place SMu1820 in the S1 family which is described as S1 RNA binding domain (PF00575)","Fri Jan 11 14:57:16 2002","","","","Koivula,T. and Hemila,H. Nucleotide sequence of a Lactococcus lactis gene cluster encoding adenylate kinase, initiation factor 1 andribosomal proteins. J. Gen. Microbiol. 137 (Pt 11): 2595-2600 (1991) [PubMed: 1783905].","","Fri Jan 11 15:18:47 2002","1","","","SMU.2004c","878" "SMu1821","1883325","1882687","639","ATGAATCTTTTAATCATGGGATTGCCAGGTGCTGGCAAAGGGACTCAGGCAGCTAAGATTGTTGAAAAATTTGGCCTTGCTCATATTTCAACGGGAGATATGTTTCGTGCAGCTATGGCTAACCAAACAGAAATGGGAACCTTGGCAAAGAGTTTTATTGATAAGGGAGAGCTTGTTCCTGATGAAGTAACCAATGGTATTGTTAAAGAGCGTCTTTCAGAATCAGATATTACTAAAAAAGGTTTCTTGCTAGATGGCTATCCACGTACCATTGAACAAGCTCATGCTTTGGATGAGATTTTATCAAAACTTAACCTTAAGCTAGATGGCGTTATCAATATTGATGTTGATCCAGCTTGTTTGGTGGAGCGTTTGAGTGGTCGTATTATCAATCGTAAGACAGGTGAAACTTATCATAAAGTCTTTAACCCACCAGCAGATTATAATGAAGATGATTATTATCAACGTGAAGATGATAAACCGGAAACAGTAAAACGTCGCTTAGATGTCAACATTGCTCAAGGGCATCCAATAATTGAATACTATCGTAATAAAGGTCTTGTTTATGATATTGAAGGAAATCAAGATATCAATTTAGTTTTTGAGACAATTGCTAAAGTTTTAGCAAATTTGTCATAA","5.10","-6.07","23623","MNLLIMGLPGAGKGTQAAKIVEKFGLAHISTGDMFRAAMANQTEMGTLAKSFIDKGELVPDEVTNGIVKERLSESDITKKGFLLDGYPRTIEQAHALDEILSKLNLKLDGVINIDVDPACLVERLSGRIINRKTGETYHKVFNPPADYNEDDYYQREDDKPETVKRRLDVNIAQGHPIIEYYRNKGLVYDIEGNQDINLVFETIAKVLANLS","1882703","From GenBank (gi:14195590): In Lactococcus lactis, this small ubiquitous enzyme is essential for maintenance and cell growth. It catalyzes the reaction: ATP + AMP = ADP + ADP. This cytoplasmic monomer belongs to the adenylate kinase family. ","adenylate kinase (ATP-AMP transphosphorylase) (superoxide-inducible protein 16)","Cytoplasm","Numerous strong matches in gapped BLAST to adenylate kinase; residues 1-211 are 82% similar to adenylate kinase of Streptococcus pyogenes (gi15674308); residues 1-211 are 81% similar to adenylate kinase of Streptococcus pneumoniae (gi15900167).See Spy0074.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0079 (2e-99).","

InterPro
IPR000850
Family

Adenylate kinase
PR00094	$\"[4-17]T$ $\"[32-46]T$ $\"[82-98]T$ $\"[156-171]T$ $\"[173-187]T$	ADENYLTKNASE
PTHR23359	$\"[1-210]T$	Adenylate_kin
PF00406	$\"[5-187]T$	ADK
PS00113	$\"[82-93]T$	ADENYLATE_KINASE

InterPro
IPR006259
Family

Adenylate kinase, subfamily
TIGR01351	$\"[2-209]T$	adk

InterPro
IPR011769
Domain

Adenylate/cytidine kinase, N-terminal
PD000657	$\"[1-45]T$	Adenylate_kin

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-208]T$	G3DSA:3.40.50.300
PTHR23359:SF22	$\"[1-210]T$	PTHR23359:SF22
SSF52540	$\"[1-212]T$	SSF52540
SSF57774	$\"[127-159]T$	SSF57774

","BeTs to 15 clades of COG0563COG name: Adenylate kinase/yeast uridylate kinaseFunctional Class: FThe phylogenetic pattern of COG0563 is a--kYqvCebrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","***** IPB000850 (Adenylate kinase) with a combined E-value of 3.7e-52. IPB000850A 4-36 IPB000850B 77-91 IPB000850C 116-146 IPB000850D 156-182***** IPB003136 (Cytidylate kinase) with a combined E-value of 1.1e-06. IPB003136A 3-36","Residues 5-186 are 85% similar to a (KINASE ADENYLATE TRANSFERASE ATP-BINDING) protein domain (PD000657) which is seen in KAD_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Jan 11 14:48:18 2002","Mon Aug 21 17:51:24 2006","Fri Feb 17 11:31:06 2006","Fri Jan 11 14:48:18 2002","Fri Jan 11 14:48:18 2002","Fri Jan 11 14:48:18 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1821 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 15 10:31:27 2002","Fri Feb 17 11:31:06 2006","pdb1ZIN Adenylate Kinase With Bound Ap5a >gi2392649pdb1Z... 224 9e-060pdb1AKY Atp:amp Phosphotransferase, Myokinase Mol_id: 1; M... 170 1e-043pdb3AKY Atp:amp Phosphotransferase, Myokinase Mol_id: 1; M... 170 1e-043","SMU.2005c","","Residues 5 to 187 (E-value = 9.2e-88) place SMu1821 in the ADK family which is described as Adenylate kinase (PF00406)","Fri Jan 11 14:48:18 2002","","","","Koivula,T. and Hemila,H. Nucleotide sequence of a Lactococcus lactis gene cluster encoding adenylate kinase, initiation factor 1 and ribosomal proteins. J. Gen. Microbiol. 137 (Pt 11): 2595-2600 (1991) [PubMed: 1783905].","","Fri Jan 11 14:48:18 2002","1","","","SMU.2005c","511" "SMu1822","1884859","1883555","1305","ATGTTTTTTAGACTTTTAAAAGACGCCCTAAAGGTGAAAAGTGTTAGAAAAAAGATTTTCTTTACTATTTTTATCATCTTTGTATTTCGTGTTGGTACACACATTACCGTACCAGGCATCAATGCTAAAAGTCTTGAACAACTAAGTGATCTACCATTTTTAAATATGCTTAACCTTGTTAGTGGTAATGCTATGAGTAACTTTTCCGTTTTTTCCATGGGGGTTAGTCCTTATATTACCGCTTCCATTGTTGTTCAACTTTTACAAATGGATATTTTACCTAAGTTTGTTGAATGGGGAAAACAAGGGGAAGTCGGGCGTCGTAAGCTGAATCAAGCAACGCGCTATATTTCACTAGTCCTTGCTTTTTTCCAATCTATTGGTATTACAGCAGGATTTAGTGCTCTATCAAGTGTTTCTCTTGTGAAGACACCAAATGTCCAGACATTTCTTTTAATTGGTGCTATTTTAACCGCAGGAAGTGTGGTTGTAACTTGGCTAGGAGATCAGATTTCGGATAAAGGTTTTGGTAATGGTGTTTCAATGATCATCTTTGCGGGAATTATTTCATCTATACCAGGGACTATCAAATCCGTTTATGAAGATTATTTTGTCAATATCCGTTCAAGCGAAATGAAGAATTCCCTTATTTTTGTGGGACTTTTGATTTTAGCTAGTCTCATCATTATTTTCTTTACAACTTTTGTTCAACAAGCAGAATATAAGATTCCAATCCAATATACTAAGTTGGCGCAAGGTGCTCCGACGAATTCTTATCTTCCTTTGAAGATAAATCCAGCTGGAGTTATTCCTGTTATTTTTGCAAGTTCTATTACAACTATTCCAAGTACTATCTTGCCATTTTTCCAACATGGTCGCGATATTCCTTGGATGACAACCTTGCAAGAATGGCTTTCTTATACTAATCCAACAGGAATGGCAGTTTATGCTGTTCTCATTGTACTTTTCTCATTCTTTTATACTTTTGTGCAAGTCAATCCTGAAAAGACAGCAGAGAATTTACAAAAAAACGCTTCTTATATTCCTAGTGTTCGACCTGGTCGTGAAACAGAGGAATACCTTTCATCGCTTCTGAAAAAATTGGCAACGATTGGTTCCATTTTCTTGGCCTTTGTTGCTTTGAGTCCAATTGTAGCTCAACAACAATTTGATTTGTCATCAAGTGTTGCTTTAGGAGGTACCAGTCTGTTAATTGTTATTTCTACAGGCATTGAAGGAATGAAGCAATTGGAAGGCTATCTGTTGAAGAGAAAATATGTTGGTTTTATGAATGTTACAGAATAG","10.40","11.48","47808","MFFRLLKDALKVKSVRKKIFFTIFIIFVFRVGTHITVPGINAKSLEQLSDLPFLNMLNLVSGNAMSNFSVFSMGVSPYITASIVVQLLQMDILPKFVEWGKQGEVGRRKLNQATRYISLVLAFFQSIGITAGFSALSSVSLVKTPNVQTFLLIGAILTAGSVVVTWLGDQISDKGFGNGVSMIIFAGIISSIPGTIKSVYEDYFVNIRSSEMKNSLIFVGLLILASLIIIFFTTFVQQAEYKIPIQYTKLAQGAPTNSYLPLKINPAGVIPVIFASSITTIPSTILPFFQHGRDIPWMTTLQEWLSYTNPTGMAVYAVLIVLFSFFYTFVQVNPEKTAENLQKNASYIPSVRPGRETEEYLSSLLKKLATIGSIFLAFVALSPIVAQQQFDLSSSVALGGTSLLIVISTGIEGMKQLEGYLLKRKYVGFMNVTE","1883571","For other 'sec' genes see SMu1674 (secA) and SMu1463 (secG).From GenBank (gi:14285762): In Lactococcus lactis, SecY is involved in protein export. It interacts with SecA and SecE to allow the translocation of proteins across the plasma membrane, by forming part of a channel. It is one of seven secretory proteins (SecA-F & SecY) that comprise the prokaryotic protein translocation apparatus. This integral membrane protein belongs to the SecY/Sec61-alpha family. ","preprotein translocase","Membrane, Cytoplasm","Numerous strong matches in gapped BLAST to preprotein translocase, SecY subunit; residues 1-434 are 77% similar to preprotein translocase of Streptococcus pyogenes (gi15674307); residues 1-434 are 67% similar to preprotein translocase, SecY subunit of Streptococcus pneumoniae (gi15900166).See Spy0073.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0078 (0.0).","

InterPro
IPR002208
Family

SecY protein
PR00303	$\"[19-37]T$ $\"[68-88]T$ $\"[110-133]T$ $\"[147-172]T$ $\"[173-196]T$ $\"[267-286]T$ $\"[310-332]T$ $\"[365-383]T$ $\"[399-417]T$	SECYTRNLCASE
PTHR10906	$\"[2-432]T$	SecY
PF00344	$\"[69-416]T$	SecY
TIGR00967	$\"[16-426]T$	3a0501s007
PS00755	$\"[69-88]T$	SECY_1

noIPR
unintegrated

unintegrated
PTHR10906:SF2	$\"[2-432]T$	PTHR10906:SF2
SSF103491	$\"[2-422]T$	SSF103491

","BeTs to 16 clades of COG0201COG name: Preprotein translocase subunit SecYFunctional Class: NThe phylogenetic pattern of COG0201 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002208 (SecY protein) with a combined E-value of 3.9e-94. IPB002208A 18-40 IPB002208B 62-88 IPB002208C 106-126 IPB002208D 157-193 IPB002208E 259-278 IPB002208F 320-354","Residues 69-173 are 76% similar to a (SUBUNIT PREPROTEIN TRANSLOCASE) protein domain (PD001056) which is seen in SECY_LACLA.Residues 3-68 are 53% similar to a (TRANSLOCASE PREPROTEIN SUBUNIT) protein domain (PD331160) which is seen in SECY_LACLA.Residues 174-328 are 62% similar to a (TRANSLOCASE PREPROTEIN SUBUNIT) protein domain (PD001699) which is seen in SECY_LACLA.Residues 330-428 are 37% similar to a (SUBUNIT SECY TRANSLOCASE PREPROTEIN) protein domain (PD338039) which is seen in O83238_TREPA.Residues 69-188 are 57% similar to a (TRANSPORT SUBUNIT TRANSMEMBRANE TRANSLOCATION) protein domain (PD004152) which is seen in SECY_BACLI.Residues 336-426 are 63% similar to a (SUBUNIT PREPROTEIN TRANSLOCASE) protein domain (PD001749) which is seen in SECY_LACLC.Residues 329-412 are 32% similar to a (PROTEOME SECY TRANSLOCASE SUBUNIT) protein domain (PD294653) which is seen in Q9PQP1_UREPA.Residues 57-173 are 31% similar to a (SECY TRANSLOCASE PREPROTEIN) protein domain (PD396969) which is seen in Q9SIQ4_ARATH.Residues 56-213 are 23% similar to a (COMPLETE ORF MITOCHONDRION PROTEOME) protein domain (PD000146) which is seen in O21257_RECAM.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Sun Jul 9 10:02:48 2006","Sun Jul 9 10:02:48 2006","Fri Feb 17 11:28:43 2006","Fri Jan 11 14:40:41 2002","Fri Jan 11 14:40:41 2002","Fri Jan 11 14:40:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1822 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:58:04 2002","","No significant hits to the NCBI PDB database.","SMU.2006c","","Residues 69 to 416 (E-value = 1.1e-156) place SMu1822 in the SecY family which is described as eubacterial secY protein (PF00344)","Fri Jan 11 14:40:41 2002","","","","Koivula,T., Palva,I. and Hemila,H. Nucleotide sequence of the secY gene from Lactococcus lactis and identification of conserved regions by comparison of four SecY proteins. FEBS Lett. 288 (1-2): 114-118 (1991) [PubMed: 1908794].","","Sun Jul 9 10:02:48 2006","1","","","SMU.2006c","12" "SMu1823","1885299","1884859","441","ATGAAACTTCATGAACTTAAACCTGCTCAAGGTTCTCGTAAAACTCGTAACCGTGTGGGTCGTGGCTCATCTTCTGGTAATGGTAAGACTGCAGGTCGTGGACAAAAAGGGCAAAAAGCTCGTAGTGGAGGTAATATCCGTTCGGGCTTTGAAGGTGGACAAACGCCACTCTTTCGTCGTCTTCCAAAACGCGGTTTTACTAATATCAATGCTAAAGAGTATGCATTGGTTAATCTTGATCAGTTAAATGTCTTTGAAGATGGTGCAGAAGTAACACCAGTTGTTCTTGTTGAAACTGGTATCGTAAAAGCTGAAAAATCAGGAATTAAAATTCTTGGTAATGGCGAATTAACTAAAAAATTAACTGTTAAGGCAGCTAAATTCTCAAAATCTGCTGAAGCAGCCATCATTGCTAAAGGTGGTTCAATCGAGGTGATCTAA","11.30","15.23","15430","MKLHELKPAQGSRKTRNRVGRGSSSGNGKTAGRGQKGQKARSGGNIRSGFEGGQTPLFRRLPKRGFTNINAKEYALVNLDQLNVFEDGAEVTPVVLVETGIVKAEKSGIKILGNGELTKKLTVKAAKFSKSAEAAIIAKGGSIEVI","1884875","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:2500269): In Staphylococcus aureus, the complete ribosomal protein binds directly to 23S ribosomal RNA and belongs to the L15P family of ribosomal proteins.","50S ribosomal protein L15, N-terminal fragment","Cytoplasm, Extracellular","Many strong matches in gapped BLAST to a large N-terminal fragment of 50S Ribosomal protein L15; residues 1-123 are 82% similar to 50S Ribosomal protein L15 of Streptococcus pneumoniae (gi15900165); residues 1-123 are 73% similar to 50S Ribosomal protein L15 of Streptococcus pyogenes (gi15674306).See Spy0072.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0077 (1e-51).","

InterPro
IPR001196
Family

Ribosomal protein L15
PF00256	$\"[110-141]T$	L15
PF01305	$\"[1-102]T$	Ribosomal_L15
PS00475	$\"[110-140]T$	RIBOSOMAL_L15

InterPro
IPR005749
Family

Ribosomal protein L15, bacterial form
PTHR12934	$\"[40-146]T$	Ribosom_L15_bac
TIGR01071	$\"[2-144]T$	rplO_bact

noIPR
unintegrated

unintegrated
G3DSA:3.100.10.10	$\"[72-144]T$	G3DSA:3.100.10.10
SSF52080	$\"[14-146]T$	SSF52080

","BeTs to 13 clades of COG0200COG name: Ribosomal protein L15Functional Class: JThe phylogenetic pattern of COG0200 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001196 (Ribosomal protein L15) with a combined E-value of 1e-23. IPB001196A 17-41 IPB001196B 120-141","Residues 1-109 are 72% similar to a (RIBOSOMAL 50S RRNA-BINDING PROTEOME) protein domain (PD003120) which is seen in RL15_STAAU.Residues 1-93 are 35% similar to a (L7 MITOCHONDRIAL RIBOSOMAL PROTEIN) protein domain (PD355776) which is seen in Q9H0Y1_HUMAN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 24 11:16:17 2006","Fri Jan 11 14:31:20 2002","Fri Feb 17 11:26:08 2006","Wed Jan 9 17:09:53 2002","Wed Jan 9 17:09:53 2002","Wed Jan 9 17:09:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1823 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Jan 11 14:31:20 2002","","No significant hits to the NCBI PDB database.","SMU.2007c","","Residues 1 to 102 (E-value = 9.4e-60) place SMu1823 in the Ribosomal_L15 family which is described as Ribosomal protein L15 amino terminal region (PF01305)Residues 110 to 141 (E-value = 5.6e-11) place SMu1823 in the L15 family which is described as Ribosomal protein L15 (PF00256)","Fri Feb 17 11:26:08 2006","","","","Kimura,M., Kimura,J. and Ashman,K. The complete primary structure of ribosomal proteins L1, L14, L15, L23, L24 and L29 fromBacillus stearothermophilus. Eur. J. Biochem. 150 (3): 491-497 (1985) [PubMed: 4018095].","","Fri Jan 11 14:32:05 2002","1","","","SMU.2007c","614" "SMu1824","1885774","1885592","183","ATGGCACAGATTAAAATTACTTTGACTAAGTCTCCAATCGGTCGCATTCCTGCACAACGTAAAACAGTTGTTGCCCTTGGACTTGGTAAATTAAATAGTTCAGTTATCAAAGAAGATAATGCCGCTATTCGTGGTATGGTTAATGCAGTTTCACATTTGGTAACTGTAGAAGATGTCAAGTAA","11.10","5.22","6364","MAQIKITLTKSPIGRIPAQRKTVVALGLGKLNSSVIKEDNAAIRGMVNAVSHLVTVEDVK","1885608","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).","50S ribosomal protein L30","Cytoplasm","Some moderate matches in gapped BLAST to 50S Ribosomal protein L30; residues 1-59 are 93% similar to 50S Ribosomal protein L30 of Streptococcus pneumoniae (gi15457752); residues 1-59 are 91% similar to 50S Ribosomal protein L30 of Streptococcus pyogenes (gi15674305).See Spy0071.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0076 (4e-25).","

InterPro
IPR000517
Domain

Ribosomal protein L30
PF00327	$\"[2-54]T$	Ribosomal_L30
PS00634	$\"[22-54]T$	RIBOSOMAL_L30

InterPro
IPR005996
Family

Ribosomal protein L30, bacterial
TIGR01308	$\"[4-58]T$	rpmD_bact

noIPR
unintegrated

unintegrated
G3DSA:3.30.1390.20	$\"[1-60]T$	G3DSA:3.30.1390.20
SSF55129	$\"[1-60]T$	Ribosomal_L30

","BeTs to 9 clades of COG1841COG name: Ribosomal protein L30/L7EFunctional Class: JThe phylogenetic pattern of COG1841 is amtkYqv-ebrh----ol--xNumber of proteins in this genome belonging to this COG is 1","***** IPB000517 (Ribosomal protein L30) with a combined E-value of 3.7e-21. IPB000517 10-57","Residues 8-58 are 76% similar to a (RIBOSOMAL 50S PROTEOME COMPLETE) protein domain (PD005137) which is seen in Q9CDY1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 11:23:18 2006","Wed Jan 9 16:58:59 2002","Fri Feb 17 11:23:18 2006","Wed Jan 9 16:58:59 2002","Wed Jan 9 16:58:59 2002","Wed Jan 9 16:58:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1824 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:09:53 2002","","No significant hits to the NCBI PDB database.","SMU.2008c","","Residues 2 to 54 (E-value = 2.8e-14) place SMu1824 in the Ribosomal_L30 family which is described as Ribosomal protein L30p/L7e (PF00327)","Wed Jan 9 16:58:59 2002","","","","","","","1","","","SMU.2008c","877" "SMu1825","1886282","1885788","495","ATGGCATTTAAAGATAATGCAGTAGAACTTGAAGAACGCGTTGTTGCGATTAACCGTGTTACAAAAGTTGTTAAGGGTGGACGTCGTCTTCGCTTTGCTGCTCTTGTAGTTGTTGGTGATCGTAATGGCCGTGTTGGTTTTGGTACTGGTAAAGCTCAAGAAGTACCAGAAGCTATTCGTAAAGCAGTAGAAGCTGCTAAGAAAAACATGATTGAGGTACCAATGGTTGGCACAACAATTCCTCACGAAGTTCGTTCAGAATTTGGTGGTGCTCGTGTCTTGTTGAAGCCAGCAGTAGAAGGTGCTGGGGTTGCTGCTGGCGGTGCTGTTCGTGCTGTTGTTGAATTAGCCGGTGTAGCAGATATTACATCAAAATCATTAGGTTCAAATACTCCAATCAACATTGTTCGTGCAACTGTTGAAGGATTGAAACAGCTTAAACGTGCTGAAGAAGTCGCTTCACTTCGCGGTGTTTCAGTCTCTGATTTGGCATAA","10.80","7.24","17105","MAFKDNAVELEERVVAINRVTKVVKGGRRLRFAALVVVGDRNGRVGFGTGKAQEVPEAIRKAVEAAKKNMIEVPMVGTTIPHEVRSEFGGARVLLKPAVEGAGVAAGGAVRAVVELAGVADITSKSLGSNTPINIVRATVEGLKQLKRAEEVASLRGVSVSDLA","1885804","For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1828 (rs8); SMu1825 (rs5) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:133964): In Geobacillus stearothermophilus, protein S5 is important in the assembly and function of the 30s ribosomal subunit and belongs to the S5P family of ribosomal proteins. ","30S ribosomal protein S5","Cytoplasm","Many strong matches in gapped BLAST to 30S ribosomal protein S5; residues 1-164 are 81% similar to 30S ribosomal protein S5 of Streptococcus pyogenes (gi15674304); residues 1-164 are 79% similar to 30S ribosomal protein S5 of Streptococcus pneumoniae (gi15900163).See Spy0069.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0075 (3e-71).","

InterPro
IPR000851
Family

Ribosomal protein S5
PTHR13718	$\"[3-164]T$	Ribosomal_S5

InterPro
IPR002197
Domain

Helix-turn-helix, Fis-type
PR01590	$\"[57-74]T$ $\"[153-164]T$	HTHFIS

InterPro
IPR005324
Domain

Ribosomal protein S5, C-terminal
PF03719	$\"[84-157]T$	Ribosomal_S5_C

InterPro
IPR005712
Family

Ribosomal protein S5, bacterial and chloroplast
TIGR01021	$\"[7-162]T$	rpsE_bact

InterPro
IPR013810
Domain

Ribosomal protein S5, N-terminal
PF00333	$\"[9-75]T$	Ribosomal_S5
PS00585	$\"[27-59]T$	RIBOSOMAL_S5
PS50881	$\"[10-73]T$	S5_DSRBD

InterPro
IPR014720
Domain

Double-stranded RNA-binding-like
G3DSA:3.30.160.20	$\"[9-72]T$	dsRNA-bd-like

InterPro
IPR014721
Domain

Ribosomal protein S5 domain 2-type fold
G3DSA:3.30.230.10	$\"[73-149]T$	Ribosomal_S5_D2-type_fold

noIPR
unintegrated

unintegrated
SSF54211	$\"[78-158]T$	SSF54211
SSF54768	$\"[3-76]T$	SSF54768

","BeTs to 17 clades of COG0098COG name: Ribosomal protein S5Functional Class: JThe phylogenetic pattern of COG0098 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000851 (Ribosomal protein S5) with a combined E-value of 7e-68. IPB000851A 14-67 IPB000851B 84-134","Residues 6-46 are 82% similar to a (RIBOSOMAL 30S 40S S5P) protein domain (PD001336) which is seen in RS5_BACST.Residues 9-46 are 63% similar to a (RIBOSOMAL 30S PROTEOME COMPLETE) protein domain (PD393625) which is seen in Q9RSL1_DEIRA.Residues 12-46 are 80% similar to a (RIBOSOMAL 30S CHLOROPLAST PROTEOME) protein domain (PD336298) which is seen in RS5_MYCTU.Residues 47-147 are 62% similar to a (RIBOSOMAL 30S 40S PROTEOME COMPLETE S5P CHLOROPLAST) protein domain (PD001364) which is seen in Q9CDY0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 11:20:38 2006","Wed Jan 9 16:53:53 2002","Fri Feb 17 11:20:38 2006","Wed Jan 9 16:53:53 2002","Wed Jan 9 16:53:53 2002","Wed Jan 9 16:53:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1825 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:28:14 2002","Fri Feb 17 11:20:38 2006","pdb1PKP Ribosomal Protein S5 (Prokaryotic) 192 2e-050pdb1EG0B Chain B, Fitting Of Components With Known Structure ... 189 2e-049pdb1DV4E Chain E, Partial Structure Of 16s Rna Of The Small R... 189 2e-049","SMU.2009c","","Residues 9 to 75 (E-value = 2.6e-42) place SMu1825 in the Ribosomal_S5 family which is described as Ribosomal protein S5, N-terminal domain (PF00333)Residues 84 to 157 (E-value = 8.9e-33) place SMu1825 in the Ribosomal_S5_C family which is described as Ribosomal protein S5, C-terminal domain (PF03719)","Fri Feb 17 11:20:38 2006","","","","Ramakrishnan,V. and Gerchman,S.E. Cloning, sequencing, and overexpression of genes for ribosomal proteins fromBacillus stearothermophilus. J. Biol. Chem. 266 (2): 880-885 (1991) [PubMed: 1985969].Kimura,M. Proteins of the Bacillus stearothermophilus ribosome. The amino acid sequences of proteins S5 and L30. J. Biol. Chem. 259 (2): 1051-1055 (1984) [PubMed: 6363400].Ramakrishnan,V. and White,S.W. The structure of ribosomal protein S5 reveals sites of interaction with 16S rRNA. Nature 358 (6389): 768-771 (1992) [PubMed: 1508272].","","Wed Jan 9 16:53:53 2002","1","","","SMU.2009c","510" "SMu1826","1886657","1886301","357","GTGATTTCGAAACCAGATAAAAATAAAATCCGCCAAAAACGCCATCGTCGTGTTCGCGGAAAACTCTCTGGAACTGCTGATCGCCCACGTTTGAACATTTTCCGTTCTAATACAGGCATCTACGCTCAAGTGATTGATGACGTAGCGGGTGTAACGCTCGCAAGTGCTTCAACTCTTGACAAAGAAGTTTCAAAAGGGACTAAAACTGAACAAGCCGTTGTTGTTGGTAAACTCGTTGCTGAACGCGCAGTAGCTAAAGGTATTTCTGAAGTGGTGTTTGACCGCGGTGGATATCTCTATCACGGACGTGTTAAGGCCTTGGCTGATGCAGCTCGTGAAAACGGATTGAAATTCTAA","11.20","12.47","12845","MISKPDKNKIRQKRHRRVRGKLSGTADRPRLNIFRSNTGIYAQVIDDVAGVTLASASTLDKEVSKGTKTEQAVVVGKLVAERAVAKGISEVVFDRGGYLYHGRVKALADAARENGLKF","1886317","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:1172978): In Bacillus subtilis, this is one of 3 proteins that mediate the attachment of the 5S RNA into the large ribosomal subunit. It belongs to the L18P family of ribosomal proteins. ","50S ribosomal protein L18","Cytoplasm","Many strong matches in gapped BLAST to 50S ribosomal protein L18; residues 1-118 are 97% similar to 50S ribosomal protein L18 of Streptococcus pyogenes (gi15674303); residues 1-118 are 95% similar to 50S ribosomal protein L18 of Streptococcus pneumoniae (gi15900162).See Spy0067.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0074 (2e-61).","

InterPro
IPR004389
Family

Ribosomal protein L18
TIGR00060	$\"[7-118]T$	L18_bact: ribosomal protein L18

InterPro
IPR005484
Family

Ribosomal protein L18P/L5E
PD001394	$\"[31-118]T$	Q8DS29_STRMU_Q8DS29;
PF00861	$\"[6-118]T$	Ribosomal_L18p

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.100	$\"[28-118]T$	no description

","BeTs to 13 clades of COG0256COG name: Ribosomal protein L18Functional Class: JThe phylogenetic pattern of COG0256 is amtkyqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 28-118 are 75% similar to a (RIBOSOMAL 50S RRNA-BINDING COMPLETE) protein domain (PD001394) which is seen in RL18_BACSU.Residues 7-117 are 40% similar to a (PROTEOME COMPLETE 50S L18) protein domain (PD396085) which is seen in Q9PLY7_CAMJE.Residues 1-29 are 75% similar to a (RIBOSOMAL PROTEOME COMPLETE 50S) protein domain (PD369874) which is seen in Q9CDX9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 11:17:25 2006","Wed Jan 9 16:47:38 2002","Fri Feb 17 11:17:25 2006","Wed Jan 9 16:47:38 2002","","Wed Jan 9 16:47:38 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1826 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 11:53:42 2002","","No significant hits to the NCBI PDB database.","SMU.2010c","","Residues 6 to 118 (E-value = 8.3e-56) place SMu1826 in the Ribosomal_L18p family which is described as Ribosomal L18p/L5e family (PF00861)","Wed Jan 9 16:47:38 2002","","","","Suh,J.W., Boylan,S.A., Oh,S.H. and Price,C.W. Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region. Gene 169 (1): 17-23 (1996) [PubMed: 8635744].","","Wed Jan 9 16:47:38 2002","1","","","SMU.2010c","613" "SMu1827","1887283","1886747","537","ATGTCACGTATTGGTAATAAAGTAATCACGTTGCCTGCTGGTGTAGAAGTCACTAATAAAGATAATGTTGTTACTGTAAAAGGCCCTAAAGGGGAGCTTACACGTGAGTTCCCAAAAGTTATTGAAATTAAAATTGAAGGAACAGAAGTAACACTTCATCGTCCAAATGATTCCAAAGAAATGAAAACAATCCATGGTACAGCTCGTGCTAACTTAAACAATATGGTTATTGGCGTTTCTGAAGGGTTCAAAAAGGAACTTGAAATGCGTGGGGTTGGTTACCGTGCTCAACTTCAAGGGAAGAAACTTGTTCTTTCAGTCGGTAAATCTCATCCAGATGAAGTTGAGGCTCCAGAAGGTATTACGTTTGAAGTACCAACTGCTACAGCCATCGTTGTTAATGGAATTAATAAAGAGGTTGTTGGTCAGACAGCAGCTTATATTCGTGGTCTTCGTGTTCCAGAACCTTATAAAGGTAAGGGAATTCGTTACGCTGGTGAGTATGTACGCCGTAAAGAAGGTAAAACAGGTAAATAA","10.50","9.73","19421","MSRIGNKVITLPAGVEVTNKDNVVTVKGPKGELTREFPKVIEIKIEGTEVTLHRPNDSKEMKTIHGTARANLNNMVIGVSEGFKKELEMRGVGYRAQLQGKKLVLSVGKSHPDEVEAPEGITFEVPTATAIVVNGINKEVVGQTAAYIRGLRVPEPYKGKGIRYAGEYVRRKEGKTGK","1886763","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:133004): In Geobacillus stearothermophilus, this protein binds directly to 23S ribosomal RNA and is located at the aminoacyl-tRNA binding site of the peptidyltransferase center. It belongs to the L6P family of ribosomal proteins.","50S ribosomal protein L6 (BL10)","Cytoplasm, Extracellular","Numerous strong matches in gapped BLAST to 50S ribosomal protein L6 (BL10); residues 1-178 are 86% similar to 50S ribosomal protein L6 of Streptococcus pneumoniae (gi15902248); residues 1-178 are 84% similar to 50S ribosomal protein L6 of Streptococcus pyogenes (gi15674302).See Spy0066.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0073 (2e-84).","

InterPro
IPR000702
Family

Ribosomal protein L6
PD002236	$\"[87-175]T$	Ribosomal_L6
PR00059	$\"[71-96]T$ $\"[99-115]T$ $\"[141-162]T$	RIBOSOMALL6
G3DSA:3.90.930.12	$\"[2-82]T$ $\"[83-178]T$	Ribosomal_L6
PTHR11655	$\"[2-178]T$	Ribosomal_L6
PF00347	$\"[11-82]T$ $\"[90-165]T$	Ribosomal_L6

InterPro
IPR002358
Family

Ribosomal protein L6, signature 1
PS00525	$\"[154-162]T$	RIBOSOMAL_L6_1

noIPR
unintegrated

unintegrated
PTHR11655:SF6	$\"[2-178]T$	PTHR11655:SF6
SSF56053	$\"[5-82]T$ $\"[83-171]T$	SSF56053

","BeTs to 17 clades of COG0097COG name: Ribosomal protein L6Functional Class: JThe phylogenetic pattern of COG0097 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002358 (Ribosomal protein L6, signature 1) with a combined E-value of 1.5e-82. IPB002358A 1-31 IPB002358B 65-113 IPB002358C 133-175 IPB002358A 27-57***** PR00059 (Ribosomal protein L6 signature) with a combined E-value of 1.5e-37. PR00059A 71-96 PR00059B 99-115 PR00059C 141-162***** IPB002359 (Ribosomal protein L6, signature 2) with a combined E-value of 7.5e-17. IPB002359A 9-39 IPB002359B 59-98 IPB002359C 128-171","Residues 1-78 are 61% similar to a (RIBOSOMAL 50S RRNA-BINDING PROTEOME COMPLETE L6P 60S) protein domain (PD003414) which is seen in Q9CDX8_LACLA.Residues 1-82 are 41% similar to a (RIBOSOMAL 50S CHLOROPLAST RRNA-BINDING) protein domain (PD051002) which is seen in RL6_BORBU.Residues 87-175 are 82% similar to a (RIBOSOMAL 50S RRNA-BINDING MITOCHONDRION PROTEOME) protein domain (PD002236) which is seen in Q9CDX8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Aug 21 17:42:22 2006","Wed Jan 9 16:30:10 2002","Fri Feb 17 11:14:23 2006","Wed Jan 9 16:30:10 2002","Wed Jan 9 16:30:10 2002","Wed Jan 9 16:30:10 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1827 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 16:35:30 2002","Fri Feb 17 11:14:23 2006","pdb1RL6A Chain A, Ribosomal Protein L6 >gi6137592pdb1C04B... 214 5e-057pdb1EG0J Chain J, Fitting Of Components With Known Structure ... 203 2e-053pdb487DJ Chain J, Seven Ribosomal Proteins Fitted To A Cryo-E... 192 2e-050","SMU.2011c","","Residues 11 to 82 (E-value = 2.3e-24) place SMu1827 in the Ribosomal_L6 family which is described as Ribosomal protein L6 (PF00347)Residues 90 to 165 (E-value = 6.3e-27) place SMu1827 in the Ribosomal_L6 family which is described as Ribosomal protein L6 (PF00347)","Fri Feb 17 11:14:23 2006","","","","Ramakrishnan,V. and Gerchman,S.E. Cloning, sequencing, and overexpression of genes for ribosomal proteins fromBacillus stearothermophilus. The Journal of biological chemistry. 266 (2): 880-885 (1991) [PubMed: 1985969].Kimura,M., Rawlings,N. and Appelt,K. The amino acid sequence of protein BL10 from the 50S subunit of the Bacillus stearothermophilus ribosome. FEBS Lett. 136, 58-64 (1981).Golden,B.L., Ramakrishnan,V. and White,S.W. Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein. The EMBO journal. 12 (13): 4901-4908 (1993) [PubMed: 8262035].","","Wed Jan 9 16:35:30 2002","1","","","SMU.2011c","509" "SMu1828","1888094","1887696","399","ATGGTTATGACTGATCCGATTGCAGACTTCTTAACTCGTATTCGTAATGCTAATCAAGCAAATCACAGCGTAGTTGAAGCTCCTGCATCAAACATCAAAAGAGGAATTGCTGAAATCCTTAAGTGTGAGGGTTTTGTAAAAGATGTTGAAGTTATTGAAGATGACAAGCAGGGTATTATCCGTATCTTTCTTAAATATGGTCAAAATGGTGAAAGAGTTATCACTGGCTTAAAACGTATTTCAAAACCGGGTCTTCGTGTCTATACAAAACGCGAAGATGTTCCAAAAGTTCTCAATGGGCTTGGGATTGCAATTATTTCAACTTCTGAAGGTCTTTTGACTGATAGAGAAGCCCGTCAAAAAAATATTGGCGGAGAAGTTATTACTTACGTTTGGTAA","9.80","3.19","14677","MVMTDPIADFLTRIRNANQANHSVVEAPASNIKRGIAEILKCEGFVKDVEVIEDDKQGIIRIFLKYGQNGERVITGLKRISKPGLRVYTKREDVPKVLNGLGIAIISTSEGLLTDREARQKNIGGEVITYVW","1887712","For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1829 (rs14); SMu1825 (rs5) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:1173279): In , this protein binds directly to the central domain of 16S ribosomal RNA and belongs to the S8P family of ribosomal proteins. ","30S ribosomal protein S8","Cytoplasm","Many strong matches in gapped BLAST to 30S ribosomal protein S8; residues 1-132 are 87% similar to 30S ribosomal protein S8 of Streptococcus pyogenes (gi15674301); residues 1-132 are 84% similar to 30S ribosomal protein S8 of Streptococcus pneumoniae (gi15900160).See Spy0065.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0072 (4e-64).","

InterPro
IPR000630
Family

Ribosomal protein S8
PD001098	$\"[11-132]T$	Ribosomal_S8
PTHR11758	$\"[2-132]T$	Ribosomal_S8
PF00410	$\"[5-132]T$	Ribosomal_S8
PS00053	$\"[102-119]T$	RIBOSOMAL_S8
SSF56047	$\"[2-132]T$	Ribosomal_S8

noIPR
unintegrated

unintegrated
G3DSA:3.30.1370.30	$\"[2-73]T$	G3DSA:3.30.1370.30
G3DSA:3.30.1490.10	$\"[75-132]T$	G3DSA:3.30.1490.10

","BeTs to 17 clades of COG0096COG name: Ribosomal protein S8Functional Class: JThe phylogenetic pattern of COG0096 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000630 (Ribosomal protein S8) with a combined E-value of 1.2e-40. IPB000630A 5-17 IPB000630B 28-50 IPB000630C 100-132 IPB000630C 75-107","Residues 38-132 are 77% similar to a (RIBOSOMAL 30S RRNA-BINDING CHLOROPLAST) protein domain (PD001098) which is seen in RS8_BACSU.Residues 39-131 are 27% similar to a (RIBOSOMAL S8 MITOCHONDRION) protein domain (PD228704) which is seen in Q9TAI6_CAFRO.Residues 4-33 are 76% similar to a (RIBOSOMAL 30S RRNA-BINDING PROTEOME) protein domain (PD337983) which is seen in Q9CDX7_LACLA.Residues 5-128 are 28% similar to a (RIBOSOMAL S8 MITOCHONDRION) protein domain (PD261898) which is seen in Q9TCB5_NEPOL.Residues 1-56 are 39% similar to a (RIBOSOMAL 30S RRNA-BINDING) protein domain (PD201229) which is seen in RS8_AQUPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:52:30 2006","Wed Jan 9 16:15:27 2002","Fri Feb 17 10:52:30 2006","Wed Jan 9 16:15:27 2002","Wed Jan 9 16:15:27 2002","Wed Jan 9 16:15:27 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1828 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 16:18:32 2002","Fri Feb 17 10:52:30 2006","pdb1SEIA Chain A, Structure Of 30s Ribosomal Protein S8 >gi1... 192 1e-050pdb1EG0E Chain E, Fitting Of Components With Known Structure ... 131 4e-032pdb1EMIA Chain A, Structure Of 16s Rrna In The Region Around ... 130 9e-032","SMU.2012c","","Residues 5 to 132 (E-value = 3.8e-72) place SMu1828 in the Ribosomal_S8 family which is described as Ribosomal protein S8 (PF00410)","Wed Jan 9 16:15:27 2002","","","","Higo,K., Otaka,E. and Osawa,S. Purification and characterization of 30S ribosomal proteins from Bacillus subtilis: correlation to Escherichia coli 30S proteins. Mol. Gen. Genet. 185 (2): 239-244 (1982) PubMed: 6806564.Henkin,T.M., Moon,S.H., Mattheakis,L.C. and Nomura,M. Cloning and analysis of the spc ribosomal protein operon of Bacillus subtilis: comparison with the spc operon of Escherichia coli. Nucleic Acids Res. 17 (18): 7469-7486 (1989) PubMed: 2508062.Suh,J.W., Boylan,S.A., Oh,S.H. and Price,C.W. Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region. Gene 169 (1): 17-23 (1996) PubMed: 8635744.","","Sat Oct 19 09:48:35 2002","1","","","SMU.2012c","612" "SMu1829","1888536","1888351","186","TTGGCTAAAAAATCTATGGTTGCTAAGAGCAAACGCCCAGCAAAATTCTCTACGCAAGCTTACACTCGTTGTGAAAAATGCGGTCGACCACACTCTGTTTACCGCAAGTTTAAACTTTGTCGTGTTTGCTTCCGTGAATTAGCATACAAAGGACAAATTCCGGGCGTAACAAAAGCTTCTTGGTAG","11.10","14.02","7009","MAKKSMVAKSKRPAKFSTQAYTRCEKCGRPHSVYRKFKLCRVCFRELAYKGQIPGVTKASW","1888367","For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1828 (rs8); SMu1825 (rs5) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:1710734): In B.subtilis, this protein is known to be required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. It belongs to the S14P family of ribosomal proteins. ","30S ribosomal protein S14","Periplasm, Cytoplasm, Extracellular","Many moderate matches in gapped BLAST to 30S ribosomal protein S14; residues 1-61 are 91% similar to 30S ribosomal protein S14 of Streptococcus pyogenes (gi13621381); residues 1-61 are 85% similar to 30S ribosomal protein S14 of Lactococcus lactis (gi15674068).See Spy0064.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0071 (9e-32).","

InterPro
IPR001209
Family

Ribosomal protein S14
PTHR19836	$\"[15-61]T$	30S RIBOSOMAL PROTEIN S14
PF00253	$\"[6-60]T$	Ribosomal_S14
PS00527	$\"[23-45]T$	RIBOSOMAL_S14

noIPR
unintegrated

unintegrated
G3DSA:4.10.830.10	$\"[1-61]T$	no description

","BeTs to 17 clades of COG0199COG name: Ribosomal protein S14Functional Class: JThe phylogenetic pattern of COG0199 is amtkYqvceBRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001209 (Ribosomal protein S14) with a combined E-value of 3.6e-26. IPB001209 23-61","Residues 1-61 are 60% similar to a (RIBOSOMAL 30S CHLOROPLAST MITOCHONDRION MITOCHONDRIAL) protein domain (PD001990) which is seen in RS14_MYCGE.Residues 13-50 are 92% similar to a (RIBOSOMAL 30S S14P PROTEOME 40S COMPLETE MULTIGENE S36) protein domain (PD351708) which is seen in Q9CDX5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:49:58 2006","Wed Jan 9 16:03:13 2002","Fri Feb 17 10:49:58 2006","Wed Jan 9 16:03:13 2002","Wed Jan 9 16:03:13 2002","Wed Jan 9 16:03:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1829 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:26:55 2002","Fri Feb 17 10:49:58 2006","pdb1FJFN Chain N, Structure Of The Thermus Thermophilus 30s R... 91 2e-020pdb1FJFN Chain N, Structure Of The Thermus Thermophilus 30s R... 123 2e-030","SMU.2014c","","Residues 1 to 61 (E-value = 1.2e-19) place SMu1829 in the Ribosomal_S14 family which is described as Ribosomal protein S14p/S29e (PF00253)","Wed Jan 9 16:03:13 2002","","","","Higo,K., Otaka,E. and Osawa,S. Purification and characterization of 30S ribosomal proteins from Bacillus subtilis: correlation to Escherichia coli 30S proteins. Mol. Gen. Genet. 185 (2): 239-244 (1982) PubMed: 6806564.Henkin,T.M., Moon,S.H., Mattheakis,L.C. and Nomura,M. Cloning and analysis of the spc ribosomal protein operon of Bacillus subtilis: comparison with the spc operon of Escherichia coli. Nucleic Acids Res. 17 (18): 7469-7486 (1989) PubMed: 2508062.Suh,J.W., Boylan,S.A., Oh,S.H. and Price,C.W. Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region. Gene 169 (1): 17-23 (1996) PubMed: 8635744.","","Sat Oct 19 09:42:21 2002","1","","","SMU.2014c","876" "SMu1830","1889093","1888551","543","ATGGCAAATCGCTTAAAAGAAAAATATCTTAATGAAGTAGTTCCTGCATTGACAGAAAAATTTAATTACACATCTGTAATGGCCGTTCCTAAGGTTGATAAAATCGTCCTTAACATGGGTGTTGGTGATGCTGTGTCAAATGCAAAAAATCTTGAAAAAGCAGCTGCTGAATTAGCGCTTATTTCAGGTCAAAAACCACTTATTACTAAAGCTAAGAAATCAATCGCCGGCTTCCGTCTTCGTGAAGGTGTTGCTATCGGTGCGAAGGTTACTCTTCGCGGACAACGCATGTATGAATTCTTAGATAAATTGGTGACAGTTTCACTTCCACGTGTCCGTGACTTCCATGGTGTCCCAACAAAATCATTTGATGGACGCGGTAATTACACACTTGGTGTGAAAGAACAATTGATCTTCCCAGAAATCAACTTTGATAATGTTGATAAAGTCCGTGGTCTTGATATTGTTATCGTTACAACTGCTAACACTGATGAAGAATCGCGTGAATTGCTGACAGGCCTTGGAATGCCTTTCGCAAAATAA","10.30","6.24","19796","MANRLKEKYLNEVVPALTEKFNYTSVMAVPKVDKIVLNMGVGDAVSNAKNLEKAAAELALISGQKPLITKAKKSIAGFRLREGVAIGAKVTLRGQRMYEFLDKLVTVSLPRVRDFHGVPTKSFDGRGNYTLGVKEQLIFPEINFDNVDKVRGLDIVIVTTANTDEESRELLTGLGMPFAK","1888567","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:132988): In Bacillus subtilis, this is one of 3 proteins that mediate the attachment of the 5S RNA into the large ribosomal subunit. It belongs to the L5P family of ribosomal proteins. ","50S ribosomal protein L5","Cytoplasm","Numerous strong matches in gapped BLAST to 50S ribosomal protein L5; residues 1-179 are 87% similar to 50S ribosomal protein L5 of Streptococcus pyogenes (gi15674299); residues 1-179 are 87% similar to 50S ribosomal protein L5 of Streptococcus pneumoniae (gi15900157).See Spy0063.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0070 (2e-86).","

InterPro
IPR002132
Family

Ribosomal protein L5
PTHR11994	$\"[1-180]T$	Ribosomal_L5
PF00281	$\"[25-81]T$	Ribosomal_L5
PF00673	$\"[85-179]T$	Ribosomal_L5_C
PS00358	$\"[58-74]T$	RIBOSOMAL_L5

InterPro
IPR003236
Family

Mitochondrial ribosomal protein L5
PD013434	$\"[9-180]T$	Ribosomal_L5_mit

noIPR
unintegrated

unintegrated
G3DSA:3.30.1440.10	$\"[2-180]T$	G3DSA:3.30.1440.10
PTHR11994:SF4	$\"[1-180]T$	PTHR11994:SF4
SSF55282	$\"[1-180]T$	SSF55282

","BeTs to 17 clades of COG0094COG name: Ribosomal protein L5Functional Class: JThe phylogenetic pattern of COG0094 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002132 (Ribosomal protein L5) with a combined E-value of 1.7e-51. IPB002132A 27-44 IPB002132B 61-103 IPB002132C 123-140","Residues 27-103 are 71% similar to a (RIBOSOMAL 50S RRNA-BINDING 60S CHLOROPLAST L5P PROTEOME) protein domain (PD001076) which is seen in Q9CDX4_LACLA.Residues 112-157 are 86% similar to a (RIBOSOMAL 50S RRNA-BINDING PROTEOME) protein domain (PD013434) which is seen in Q9CDX4_LACLA.Residues 7-173 are 31% similar to a (RIBOSOMAL MITOCHONDRION L5 MITOCHONDRIAL) protein domain (PD358556) which is seen in RM05_MARPO.Residues 104-178 are 56% similar to a (RIBOSOMAL 50S RRNA-BINDING CHLOROPLAST) protein domain (PD375218) which is seen in RK5_EUGGR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:45:59 2006","Wed Jan 9 15:46:28 2002","Fri Feb 17 10:45:59 2006","Wed Jan 9 15:46:28 2002","Wed Jan 9 15:46:28 2002","Wed Jan 9 15:46:28 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1830 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 11:51:57 2002","Fri Feb 17 10:45:59 2006","pdb1FFKD Chain D, Crystal Structure Of The Large Ribosomal Su... 80 2e-016pdb1FFKD Chain D, Crystal Structure Of The Large Ribosomal Su... 187 1e-048","SMU.2015c","","Residues 25 to 81 (E-value = 1.1e-29) place SMu1830 in the Ribosomal_L5 family which is described as Ribosomal protein L5 (PF00281)Residues 85 to 179 (E-value = 4.1e-51) place SMu1830 in the Ribosomal_L5_C family which is described as ribosomal L5P family C-terminus (PF00673)","Fri Feb 17 10:45:59 2006","","","","Henkin,T.M., Moon,S.H., Mattheakis,L.C. and Nomura,M. Cloning and analysis of the spc ribosomal protein operon of Bacillus subtilis: comparison with the spc operon of Escherichia coli. Nucleic Acids Res. 17 (18): 7469-7486 (1989) PubMed: 2508062.Suh,J.W., Boylan,S.A., Oh,S.H. and Price,C.W. Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region. Gene 169 (1): 17-23 (1996) PubMed: 8635744.","","Sat Oct 19 09:36:54 2002","1","","","SMU.2015c","508" "SMu1831","1889422","1889117","306","ATGTTTGTAAAAAAAGGCGATAAAGTTCGCGTTATTGCTGGAAAGGACAAAGGTGTTGAAGCTGTAGTTCTTAAAGCTTTTCCGAAAATTAATAAAGTTGTTGTTGAAGGTGTGGCCATTGTTAAAAAACACCAAAAACCTAACAATGAGAACCCTCAAGGTGCTATCGTAGAAAAGGAAGCACCTATCCATGTATCAAACGTACAAGTTCTTGATAAAAATGGAGTTGCGGGTCGTGTTGGCTATAAAGTTGTTGATGGTAAAAAAGTTCGCTACAACAAAAAATCAGGCGAAGTACTTGATTAA","10.70","10.47","10954","MFVKKGDKVRVIAGKDKGVEAVVLKAFPKINKVVVEGVAIVKKHQKPNNENPQGAIVEKEAPIHVSNVQVLDKNGVAGRVGYKVVDGKKVRYNKKSGEVLD","1889133","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:7674236): In Geobacillus stearothermophilus, this protein is found in the ribonucleoprotein core and is involved in the early assembly of the 50S subunit. It is not involved in the functions of the mature 50S subunit and it belongs to the L24P family of ribosomal proteins.","50S ribosomal protein L24","Periplasm, Cytoplasm","Many moderate matches in gapped BLAST to 50S ribosomal protein L24; residues 1-101 are 90% similar to 50S ribosomal protein L24 of Streptococcus pyogenes (gi13621379); residues 1-101 are 87% similar to 50S ribosomal protein L24 of Streptococcus pneumoniae (gi7674236).See Spy0062.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0069 (3e-52).","

InterPro
IPR003256
Family

Ribosomal protein L24
PD001677	$\"[5-38]T$	Ribosomal_L24
PTHR12903	$\"[1-101]T$	Ribosomal_L24
TIGR01079	$\"[1-100]T$	rplX_bact

InterPro
IPR005824
Domain

KOW
PF00467	$\"[3-36]T$	KOW

InterPro
IPR005825
Family

Ribosomal protein L24/L26
PS01108	$\"[6-23]T$	RIBOSOMAL_L24

InterPro
IPR006646
Domain

KOW (Kyrpides, Ouzounis, Woese) motif
SM00739	$\"[2-29]T$	KOW

InterPro
IPR008991
Domain

Translation protein SH3-like
SSF50104	$\"[1-90]T$	Transl_SH3_like

","BeTs to 16 clades of COG0198COG name: Ribosomal protein L24Functional Class: JThe phylogenetic pattern of COG0198 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000302 (Ribosomal protein L24/bacterial NUSG) with a combined E-value of 3.2e-24. IPB000302A 3-37 IPB000302B 60-70","Residues 70-101 are 96% similar to a (RIBOSOMAL 50S PROTEOME COMPLETE) protein domain (PD226180) which is seen in RL24_STRPN.Residues 3-69 are 82% similar to a (RIBOSOMAL 50S CHLOROPLAST PROTEOME COMPLETE PRECURSOR) protein domain (PD001677) which is seen in RL24_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:44:10 2006","Wed Jan 9 15:40:01 2002","Fri Feb 17 10:44:10 2006","Wed Jan 9 15:40:01 2002","Wed Jan 9 15:40:01 2002","Wed Jan 9 15:40:01 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1831 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 11:50:54 2002","","No significant hits to the NCBI PDB database.","SMU.2016c","","Residues 3 to 36 (E-value = 1.6e-08) place SMu1831 in the KOW family which is described as KOW motif (PF00467)","Wed Jan 9 15:40:01 2002","","","","Henkin,T.M., Moon,S.H., Mattheakis,L.C. and Nomura,M.Kimura,M., Kimura,J. and Ashman,K. The complete primary structure of ribosomal proteins L1, L14, L15, L23, L24 and L29 from Bacillus stearothermophilus. Eur. J. Biochem. 150 (3): 491-497 (1985) PubMed: 4018095.","","Sat Oct 19 09:32:49 2002","1","","","SMU.2016c","747" "SMu1832","1889956","1889588","369","ATGATTCAATCAGAAAGTCGTTTAAAAGTCGCTGACAACAGTGGTGCCCGCGAAATCCTGACTATCAAAGTTCTTGGCGGTTCAGGTCGTAAATTTGCGAACATCGGTGATGTCATCGTTGCTTCAGTAAAACAAGCTACTCCTGGTGGTGCGGTTAAAAAAGGTGATGTGGTGAAAGCCGTTATTGTTCGTACTAAATCAGGTGCTCGTCGTGCTGATGGTTCATACATCAAATTTGATGAGAATGCAGCTGTTATTATCCGTGATGATAAAACACCTCGCGGAACTCGTATCTTTGGTCCTGTTGCTCGTGAATTGCGTGAAGGTAACTTCATGAAGATCGTGTCACTAGCGCCAGAAGTACTTTAA","11.00","8.99","13005","MIQSESRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIRDDKTPRGTRIFGPVARELREGNFMKIVSLAPEVL","1889604","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:7674183): In Streptococcus pneumoniae, this protein binds directly to 23S ribosomal RNA and belongs to the L14P family of ribosomal proteins. ","50S ribosomal protein L14","Cytoplasm","Many moderate matches in gapped BLAST to 50S ribosomal protein L14; residues 1-122 are 84% similar to 50S ribosomal protein L14 of Streptococcus pneumoniae (gi7674183); residues 1-122 are 81% similar to 50S ribosomal protein L14 of Streptococcus pyogenes (gi15674297).See Spy0061.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0068 (6e-51).","

InterPro
IPR000218
Family

Ribosomal protein L14b/L23e
PD001093	$\"[1-121]T$	Ribosomal_L14
G3DSA:2.40.150.20	$\"[1-122]T$	Ribosomal_L14
PTHR11761	$\"[1-122]T$	Ribosomal_L14
PF00238	$\"[1-122]T$	Ribosomal_L14
PS00049	$\"[60-86]T$	RIBOSOMAL_L14
SSF50193	$\"[1-122]T$	Ribosomal_L14

InterPro
IPR005745
Family

Ribosomal protein L14, bacterial and organelle form
PTHR11761:SF3	$\"[1-122]T$	Ribosom_L14_bac
TIGR01067	$\"[1-122]T$	rplN_bact

","BeTs to 17 clades of COG0093COG name: Ribosomal protein L14Functional Class: JThe phylogenetic pattern of COG0093 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000218 (Ribosomal protein L14b/L23e family) with a combined E-value of 5.2e-71. IPB000218A 1-26 IPB000218B 32-67 IPB000218C 73-108 IPB000218D 113-122","Residues 1-122 are 84% similar to a (RIBOSOMAL 50S CHLOROPLAST RRNA-BINDING MITOCHONDRION 60S) protein domain (PD001093) which is seen in RL14_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:42:22 2006","Wed Jan 9 15:17:24 2002","Fri Feb 17 10:42:22 2006","Wed Jan 9 15:17:24 2002","Wed Jan 9 15:17:24 2002","Wed Jan 9 15:17:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1832 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 11:50:10 2002","Fri Feb 17 10:42:22 2006","pdb487DM Chain M, Seven Ribosomal Proteins Fitted To A Cryo-E... 176 9e-046pdb1FFKH Chain H, Crystal Structure Of The Large Ribosomal Su... 76 2e-015pdb487DM Chain M, Seven Ribosomal Proteins Fitted To A Cryo-E... 182 2e-047","SMU.2017c","","Residues 1 to 122 (E-value = 3.5e-76) place SMu1832 in the Ribosomal_L14 family which is described as Ribosomal protein L14p/L23e (PF00238)","Wed Jan 9 15:17:24 2002","","","","Henkin,T.M., Moon,S.H., Mattheakis,L.C. and Nomura,M. Cloning and analysis of the spc ribosomal protein operon of Bacillus subtilis: comparison with the spc operon of Escherichiacoli. Nucleic Acids Res. 17 (18): 7469-7486 (1989) PubMed: 2508062.Suh,J.W., Boylan,S.A., Oh,S.H. and Price,C.W. Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region. Gene 169 (1): 17-23 (1996) PubMed: 8635744.","","Sat Oct 19 09:29:19 2002","1","","","SMU.2017c","746" "SMu1833","1890243","1889983","261","ATGGAACGTAAACAACGTAGAACGCTAGTTGGTCGTGTTGTGTCTGATAAAATGGACAAAACAATCACAGTTGTAGTTGAAACTAAACGTAACCACCCAGTCTATGGTAAACGTATTAACTACTCAAAGAAATATAAGGCTCATGATGAAAACAATATTGCAAAAGCAGGCGATATTGTTCGTATCATGGAAACTCGTCCGCTTTCAGCAACAAAACGTTTTCGTCTTGTTGAAGTGGTTGAAGAAGCTGTCATTATTTAA","11.00","9.47","10008","MERKQRRTLVGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKKYKAHDENNIAKAGDIVRIMETRPLSATKRFRLVEVVEEAVII","1889999","For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1836 (rs3); SMu1829 (rs14); SMu1828 (rs8); SMu1825 (rs5) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:7388155): In Streptococcus pneumoniae, this protein, S17, binds specifically to the 5' end of 16S ribosomal RNA and belongs to the S17P family of ribosomal proteins. ","30S ribosomal protein S17","Cytoplasm","Many moderate matches in gapped BLAST to 30S ribosomal protein S17; residues 1-86 are 93% similar to 30S ribosomal protein S17 of Streptococcus pyogenes (gi15674296); residues 1-86 are 93% similar to 30S ribosomal protein S17 of Streptococcus pneumoniae (gi7388155).See Spy0060.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0067 (5e-42).","

InterPro
IPR000266
Family

Ribosomal protein S17
PD001295	$\"[6-77]T$	Ribosomal_S17
PR00973	$\"[25-48]T$ $\"[57-67]T$ $\"[67-74]T$	RIBOSOMALS17
PTHR10744	$\"[3-86]T$	Ribosomal_S17
PF00366	$\"[11-79]T$	Ribosomal_S17
PS00056	$\"[57-69]T$	RIBOSOMAL_S17

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[4-81]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
SSF50249	$\"[5-83]T$	Nucleic_acid_OB

","BeTs to 17 clades of COG0186COG name: Ribosomal protein S17Functional Class: JThe phylogenetic pattern of COG0186 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000266 (Ribosomal protein S17) with a combined E-value of 2.3e-34. IPB000266A 11-47 IPB000266B 57-74","Residues 11-79 are 97% similar to a (RIBOSOMAL 30S RRNA-BINDING 40S CHLOROPLAST PROTEOME) protein domain (PD001295) which is seen in RS17_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:40:12 2006","Wed Jan 9 15:10:26 2002","Fri Feb 17 10:40:12 2006","Wed Jan 9 15:10:26 2002","Wed Jan 9 15:10:26 2002","Wed Jan 9 15:10:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1833 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:25:42 2002","Fri Feb 17 10:40:12 2006","pdb1EG0G Chain G, Fitting Of Components With Known Structure ... 138 1e-034pdb1QD7I Chain I, Partial Model For 30s Ribosomal Subunit 134 2e-033pdb1RIP Ribosomal Protein S17 (Nmr, 6 Structures) 134 2e-033","SMU.2018c","","Residues 11 to 79 (E-value = 7.1e-38) place SMu1833 in the Ribosomal_S17 family which is described as Ribosomal protein S17 (PF00366)","Wed Jan 9 15:10:26 2002","","","","Herfurth,E., Hirano,H. and Wittmann-Liebold,B. The amino-acid sequences of the Bacillus stearothermophilus ribosomal proteins S17 and S21 and their comparison to homologous proteins of other ribosomes. Biol. Chem. Hoppe-Seyler 372 (10): 955-961 (1991) PubMed: 1772592.","","Sat Oct 19 09:24:19 2002","1","","","SMU.2018c","745" "SMu1834","1890473","1890264","210","ATGAAACTTCAAGAAATTAAAGATTTTGTTAAAGAGCTTCGTGGTCTTTCTCAAGAAGAACTTGCTAAGAAAGAAAACGAACTTAAGAAAGAACTTTTCGATCTTCGTTTCCAAGCTGCAGCAGGTCAACTTGATCAAACTGCCCGTTTGAACGAAGTGAAAAAGCAAATTGCACGTGTTAAAACCGTGCAAGCAGAAACGAAAGAATAG","9.80","1.99","8013","MKLQEIKDFVKELRGLSQEELAKKENELKKELFDLRFQAAAGQLDQTARLNEVKKQIARVKTVQAETKE","1890280","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).","50s ribosomal protein L29","Cytoplasm","Some weak matches in gapped BLAST to 50S ribosomal protein L29; residues 1-68 are 72% similar to 50S ribosomal protein L29 of Streptococcus pyogenes (gi15674295); residues 1-68 are 64% similar to 50S ribosomal protein L29 of Streptococcus pneumoniae (gi7674275).See Spy0059.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0066 (4e-21).","

InterPro
IPR001854
Family

Ribosomal protein L29
PF00831	$\"[10-67]T$	Ribosomal_L29
TIGR00012	$\"[12-67]T$	L29
PS00579	$\"[46-60]T$	RIBOSOMAL_L29
SSF46561	$\"[10-69]T$	Ribosomal_L29

noIPR
unintegrated

unintegrated
G3DSA:1.10.287.310	$\"[10-66]T$	G3DSA:1.10.287.310

","BeTs to 10 clades of COG0255COG name: Ribosomal protein L29Functional Class: JThe phylogenetic pattern of COG0255 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001854 (Ribosomal protein L29) with a combined E-value of 1.1e-28. IPB001854A 12-42 IPB001854B 46-67","Residues 11-63 are 64% similar to a (RIBOSOMAL 50S L29P 60S) protein domain (PD188758) which is seen in RL29_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:38:05 2006","Wed Jan 9 12:50:46 2002","Fri Feb 17 10:38:05 2006","Wed Jan 9 12:50:46 2002","Wed Jan 9 12:50:46 2002","Wed Jan 9 12:50:46 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1834 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 15:17:45 2002","","No significant hits to the NCBI PDB database.","SMU.2019c","","Residues 10 to 67 (E-value = 1.2e-28) place SMu1834 in the Ribosomal_L29 family which is described as Ribosomal L29 protein (PF00831)","Wed Jan 9 12:50:46 2002","","","","Kimura,M., Kimura,J. and Ashman,K. The complete primary structure of ribosomal proteins L1, L14, L15, L23, L24 and L29 from Bacillus stearothermophilus. Eur. J. Biochem. 150 (3): 491-497 (1985) [PubMed: 4018095].","","Wed Jan 9 12:50:46 2002","1","","","SMU.2019c","875" "SMu1835","1890896","1890483","414","ATGTTAGTACCTAAGCGTGTTAAACATCGTCGTGAATTCCGTGGAAAAATGCGTGGTGAAGCTAAAGGCGGTAAGGAAGTAGCTTTTGGAGAATATGGTCTGCAAGCTACAACTAGTCACTGGATTACTAATCGTCAAATTGAGGCTGCTCGTATCGCTATGACGCGTTACATGAAACGTGGTGGTAAAGTTTGGATTAAAATCTTTCCTCATAAGTCCTACACTGCTAAGGCCATCGGTGTACGTATGGGATCTGGGAAAGGTGCTCCAGAAGGCTGGGTCGCACCAGTTAAGCGTGGAAAAATCATGTTTGAAATTGCTGATGTTCCAGAAGAAGTTGCCCGTGAAGCTCTTCGCCTTGCAAGCCACAAATTACCAGTTAAAACTAAATTCGTAAAACGTGAAGCAGAATAA","11.40","18.95","15486","MLVPKRVKHRREFRGKMRGEAKGGKEVAFGEYGLQATTSHWITNRQIEAARIAMTRYMKRGGKVWIKIFPHKSYTAKAIGVRMGSGKGAPEGWVAPVKRGKIMFEIADVPEEVAREALRLASHKLPVKTKFVKREAE","1890499","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:7674208): In S.pneumoniae, this protein binds directly to 23S ribosomal RNA and is located at the a site of the peptidyltransferase center and belongs to the L16P family of ribosomal proteins. ","50S ribosomal protein L16","Cytoplasm","Many strong matches in gapped BLAST to 50S Ribosomal protein L16; residues 1-137 are 96% similar to 50S Ribosomal protein L16 of Streptococcus pneumoniae (gi7674208); residues 1-137 are 95% similar to 50S Ribosomal protein L16 of Streptococcus pyogenes (gi15674294).See Spy0057.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0065 (4e-74).","

InterPro
IPR000114
Family

Ribosomal protein L16
PR00060	$\"[24-36]T$ $\"[42-53]T$ $\"[58-87]T$ $\"[88-117]T$	RIBOSOMALL16
PF00252	$\"[1-132]T$	Ribosomal_L16
TIGR01164	$\"[2-127]T$	rplP_bact
PS00586	$\"[59-70]T$	RIBOSOMAL_L16_1
PS00701	$\"[82-93]T$	RIBOSOMAL_L16_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.1170.10	$\"[31-135]T$	G3DSA:3.90.1170.10
PTHR12220	$\"[1-135]T$	PTHR12220
SSF54686	$\"[1-135]T$	SSF54686

","BeTs to 16 clades of COG0197COG name: Ribosomal protein L16/L10EFunctional Class: JThe phylogenetic pattern of COG0197 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000114 (Ribosomal protein L16) with a combined E-value of 1.9e-47. IPB000114A 1-19 IPB000114B 60-114","Residues 7-132 are 96% similar to a (RIBOSOMAL 50S CHLOROPLAST 60S RRNA-BINDING MITOCHONDRION) protein domain (PD001146) which is seen in RL16_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:34:34 2006","Wed Jan 9 12:43:17 2002","Fri Feb 17 10:34:34 2006","Wed Jan 9 12:43:17 2002","Wed Jan 9 12:43:17 2002","Wed Jan 9 12:43:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1835 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 12:44:33 2002","","No significant hits to the NCBI PDB database.","SMU.2020c","","Residues 1 to 132 (E-value = 2.6e-81) place SMu1835 in the Ribosomal_L16 family which is described as Ribosomal protein L16 (PF00252)","Wed Jan 9 12:43:17 2002","","","","Aarestrup,F.M. and Jensen,L.B. Presence of variations in ribosomal protein L16 corresponding to susceptibility of enterococci to oligosaccharides (Avilamycin andEvernimicin). Antimicrob. Agents Chemother. 44 (12): 3425-3427 (2000) PubMed: 11083650.","","Sat Oct 19 09:20:26 2002","1","","","SMU.2020c","611" "SMu1836","1891526","1890900","627","ATGCGTGTCGGTATCATTCGTGATTGGGATGCAAAATGGTATGCTGAAAAAGAATACGCGGATTACCTTCATGAAGATCTCGCAATCCGTAAATTCATTCAAAAAGAGTTGGCTGACGCCGCAGTTTCAACTATTGAAATTGAACGTGCAGTCAATAAGGTAAATGTTTCCCTTCATACTGCAAAACCTGGTATGGTTATCGGTAAAGGCGGAGCAAATGTCGATGCTCTTCGTGCTCAACTTAACAAATTGACTGGAAAACAAGTTCACATTAATATTGTTGAGATCAAATCACCAGATCTTGATGCTCACCTTGTTGGTGAAAATATTGCTCGTCAGCTTGAGCAACGTGTTGCTTTCCGTCGTGCTCAAAAGCAAGCAATCCAACGTACTATGCGTGCAGGAGCTAAAGGAATTAAAACTCAAGTATCGGGTCGTTTAAATGGTGCGGACATCGCACGTAGCGAAGGATATTCAGAAGGAACTGTTCCACTTCACACACTTCGTGCGGATATCGATTATGCTTGGGAAGAAGCTGATACGACTTATGGTAAGCTTGGTGTTAAAGTTTGGATTTACCGTGGCGAAATTCTTCCAGCTCGTAAAAACACTAAAGGAGGGAAATAA","10.40","9.21","23158","MRVGIIRDWDAKWYAEKEYADYLHEDLAIRKFIQKELADAAVSTIEIERAVNKVNVSLHTAKPGMVIGKGGANVDALRAQLNKLTGKQVHINIVEIKSPDLDAHLVGENIARQLEQRVAFRRAQKQAIQRTMRAGAKGIKTQVSGRLNGADIARSEGYSEGTVPLHTLRADIDYAWEEADTTYGKLGVKVWIYRGEILPARKNTKGGK","1890916","For other 'rs' genes see SMu1937 (rs4); SMu1847 (rs2); SMu1833 (rs17); SMu1829 (rs14); SMu1828 (rs8); SMu1825 (rs5) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:7388194): In , this protein is involved in the binding of initiator met-tRNA and belongs to the S3P family of ribosomal proteins. It contains 1 KH domain. ","30S ribosomal protein S3","Cytoplasm","Numerous strong matches in gapped BLAST to 30S Ribosomal protein S3; residues 1-208 are 96% similar to 30S Ribosomal protein S3 of Streptococcus pneumoniae (gi7388194); residues 1-208 are 96% similar to 30S Ribosomal protein S3 of Streptococcus pyogenes (gi15674293).See Spy0056.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0064 (1e-114).","

InterPro
IPR001351
Domain

Ribosomal protein S3, C-terminal
G3DSA:3.30.1140.32	$\"[98-197]T$	no description
PF00189	$\"[109-192]T$	Ribosomal_S3_C
PS00548	$\"[153-187]T$	RIBOSOMAL_S3

InterPro
IPR004044
Domain

KH, type 2
PF07650	$\"[53-107]T$	KH_2
PS50823	$\"[29-97]T$	KH_TYPE_2

InterPro
IPR004087
Domain

KH
SM00322	$\"[50-115]T$	KH

InterPro
IPR005704
Family

Bacterial ribosomal protein S3
TIGR01009	$\"[1-201]T$	rpsC_bact: ribosomal protein S3

InterPro
IPR008282
Domain

Ribosomal protein S3, N-terminal
PF00417	$\"[1-52]T$	Ribosomal_S3_N

InterPro
IPR009019
Domain

KH, prokaryotic type
G3DSA:3.30.300.20	$\"[8-97]T$	no description

noIPR
unintegrated

unintegrated
PTHR11760	$\"[80-201]T$	30S/40S RIBOSOMAL PROTEIN S3
PTHR11760:SF10	$\"[80-201]T$	CHLOROPLAST 30S RIBOSOMAL PROTEIN S3

","BeTs to 17 clades of COG0092COG name: Ribosomal protein S3Functional Class: JThe phylogenetic pattern of COG0092 is amtkyqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001351 (Ribosomal protein S3) with a combined E-value of 7.9e-25. IPB001351B 138-174","Residues 27-129 are 95% similar to a (RIBOSOMAL 30S TRNA-BINDING PROTEOME) protein domain (PD001959) which is seen in RS3_STRPN.Residues 74-192 are 31% similar to a (RIBOSOMAL S3 MITOCHONDRION MITOCHONDRIAL) protein domain (PD269017) which is seen in Q95749_ARATH.Residues 29-128 are 49% similar to a (RIBOSOMAL CHLOROPLAST 30S TRNA-BINDING) protein domain (PD188071) which is seen in RS3_LEPIN.Residues 130-196 are 97% similar to a (RIBOSOMAL 30S CHLOROPLAST TRNA-BINDING MITOCHONDRION) protein domain (PD000851) which is seen in Q9CDW8_LACLA.Residues 1-191 are 22% similar to a (S3 MITOCHONDRION RIBOSOMAL) protein domain (PD268919) which is seen in Q9G8W8_EEEEE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:30:15 2006","Wed Jan 9 12:37:42 2002","Fri Feb 17 10:30:15 2006","Wed Jan 9 12:37:42 2002","Wed Jan 9 12:37:42 2002","Wed Jan 9 12:37:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1836 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 15:18:23 2002","Fri Feb 17 10:30:15 2006","pdb1FJFC Chain C, Structure Of The Thermus Thermophilus 30s R... 215 5e-057","SMU.2021c","","Residues 1 to 52 (E-value = 3e-16) place SMu1836 in the Ribosomal_S3_N family which is described as Ribosomal protein S3, N-terminal domain (PF00417)Residues 55 to 102 (E-value = 7.4e-07) place SMu1836 in the KH family which is described as KH domain (PF00013)Residues 109 to 192 (E-value = 8.6e-51) place SMu1836 in the Ribosomal_S3_C family which is described as Ribosomal protein S3, C-terminal domain (PF00189)","Fri Feb 17 10:30:15 2006","","","","Higo,K., Otaka,E. and Osawa,S. Purification and characterization of 30S ribosomal proteins from Bacillus subtilis: correlation to Escherichia coli 30S proteins. Mol. Gen. Genet. 185 (2): 239-244 (1982) [PubMed: 6806564].","","Wed Jan 9 12:37:42 2002","1","","","SMU.2021c","226" "SMu1837","1891910","1891566","345","ATGGCAGAAATTACTTCAGCTAAAGCAATGGCTCGTACAGTCCGTGTTTCACCTCGTAAAACACGTCTTGTGCTTGATCTTATTCGTGGTAAGAACGTTGCTGACGCAATCGCAATCTTGAAATTCACTCCAAACAAAGCTGCTCGTATTGTTGAGAAAACTCTTAACTCTGCTGTCGCAAATGCAGAAAATAACTTTGGTTTGGAAAAAGCTAATTTGGTCGTATCTGAAACTTTCGCAAACGAAGGACCAACGATGAAACGTTTCCGTCCGCGTGCGAAGGGTTCGGCTTCACCAATCAATAAACGTACAACTCACGTTACTGTAGTTGTAGAAGAAAAATAA","11.50","11.23","12428","MAEITSAKAMARTVRVSPRKTRLVLDLIRGKNVADAIAILKFTPNKAARIVEKTLNSAVANAENNFGLEKANLVVSETFANEGPTMKRFRPRAKGSASPINKRTTHVTVVVEEK","1891582","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi7674235): In S.pneumoniae, this protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins; e.g. L4, L17, and L20. It is important during the early stages of 50S reconstitution and belongs to the L22P family of ribosomal proteins.","50S ribosomal protein L22","Cytoplasm","Many moderate matches in gapped BLAST to 50S ribosomal protein L22; residues 1-114 are 95% similar to 50S ribosomal protein L22 of Streptococcus pyogenes (gi15674292); residues 1-114 are 87% similar to 50S ribosomal protein L22 of Streptococcus pneumoniae (gi7674235).See Spy0055.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0063 (3e-58).","

InterPro
IPR001063
Family

Ribosomal protein L22/L17
PD001032	$\"[35-113]T$	Ribosomal_L22
G3DSA:3.90.470.10	$\"[5-113]T$	Ribosomal_L22
PF00237	$\"[9-113]T$	Ribosomal_L22
PS00464	$\"[87-111]T$	RIBOSOMAL_L22
SSF54843	$\"[5-114]T$	Ribosomal_L22

InterPro
IPR005727
Family

Ribosomal protein L22, bacterial and organelle form
PTHR13501	$\"[9-113]T$	Ribosom_L22_bac
TIGR01044	$\"[9-111]T$	rplV_bact

","BeTs to 17 clades of COG0091COG name: Ribosomal protein L22Functional Class: JThe phylogenetic pattern of COG0091 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001063 (Ribosomal protein L22p / L17e) with a combined E-value of 1.7e-60. IPB001063A 9-39 IPB001063B 40-65 IPB001063C 68-111","Residues 8-111 are 87% similar to a (RIBOSOMAL 50S RRNA-BINDING CHLOROPLAST COMPLETE 60S) protein domain (PD001032) which is seen in RL22_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Feb 17 10:27:13 2006","Wed Jan 9 12:23:32 2002","Fri Feb 17 10:27:13 2006","Wed Jan 9 12:23:32 2002","Wed Jan 9 12:23:32 2002","Wed Jan 9 12:23:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1837 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 12:31:06 2002","Fri Feb 17 10:27:13 2006","pdb1BXEA Chain A, Ribosomal Protein L22 From Thermus Thermoph... 109 1e-025","SMU.2022c","","Residues 9 to 113 (E-value = 6.5e-60) place SMu1837 in the Ribosomal_L22 family which is described as Ribosomal protein L22p/L17e (PF00237)","Wed Jan 9 12:23:32 2002","","","","Kromer,W.J., Hatakeyama,T. and Kimura,M. Nucleotide sequences of Bacillus stearothermophilus ribosomal protein genes: part of the ribosomal S10 operon. Biol. Chem. Hoppe-Seyler 371 (7): 631-636 (1990) PubMed: 2222862.","","Sat Oct 19 09:12:41 2002","1","","","SMU.2022c","744" "SMu1838","1892049","1891927","123","ATGAATCGTAAACATGTTCCTGTTTACATTCAAGAGGACATGGTAGGTCACAAGCTTGGTGAGTTTGCACCGACTCGTACTTACAAAGGTCATGCAACTGATGATAAGAAAACACGTCGTTAA","10.70","4.70","4695","MNRKHVPVYIQEDMVGHKLGEFAPTRTYKGHATDDKKTRR","1891943","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1841 (rps10);SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).From GenBank (gi:7388179): Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. It belongs to the S19P family of ribosomal proteins.","30S ribosomal protein S19, C-terminal fragment","Extracellular, Periplasm","Many weak matches in gapped BLAST to the C-terminal end of 30S ribosomal protein S19; residues 3-40 are 97% similar to 30S ribosomal protein S19 of Streptococcus pyogenes (gi15674291); residues 3-40 are 97% similar to 30S ribosomal protein S19 of Streptococcus pneumoniae (gi15900149).See Spy0053.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0062 (2e-18).","

InterPro
IPR002222
Family

Ribosomal protein S19/S15
PD001012	$\"[3-31]T$	Ribosomal_S19
PR00975	$\"[1-13]T$ $\"[13-28]T$	RIBOSOMALS19
G3DSA:3.30.860.10	$\"[3-40]T$	Ribosomal_S19
PTHR11880	$\"[3-40]T$	Ribosomal_S19
PF00203	$\"[3-31]T$	Ribosomal_S19
SSF54570	$\"[3-33]T$	Ribosomal_S19

noIPR
unintegrated

unintegrated
PTHR11880:SF1	$\"[3-40]T$	PTHR11880:SF1

","BeTs to 17 clades of COG0185COG name: Ribosomal protein S19Functional Class: JThe phylogenetic pattern of COG0185 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 3-31 are identical to a (RIBOSOMAL 30S CHLOROPLAST RRNA-BINDING MITOCHONDRION) protein domain (PD001012) which is seen in RS19_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 15:13:55 2006","Wed Jan 9 12:21:23 2002","Fri Feb 10 10:41:36 2006","Tue Jan 8 17:36:25 2002","","Tue Jan 8 17:36:25 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1838 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 12:21:23 2002","Fri Feb 10 10:41:36 2006","pdb1FKAS Chain S, Structure Of Functionally Activated Small R... 64 3e-012pdb1QKFA Chain A, Solution Structure Of The Ribosomal Protein... 64 3e-012pdb1FKAS Chain S, Structure Of Functionally Activated Small R... 79 5e-017","SMU.2023c","","No significant hits to the Pfam 11.0 database","Tue Jan 8 17:36:25 2002","24380365","","","Higo,K., Otaka,E. and Osawa,S. Purification and characterization of 30S ribosomal proteins from Bacillus subtilis: correlation to Escherichia coli 30S proteins.Mol. Gen. Genet. 185 (2), 239-244 (1982) PubMed: 6806564.","","Sat Oct 19 09:08:52 2002","1","","","SMU.2023c","996" "SMu1839","1892134","1892039","96","ATGGCAAACGTAAAACTATTTGACCAAACTGGTAAAGAAGCTGGTGAAGTAACACTTAACGACGCTATCTTCGGTATCGAACCAAATGAATCGTAA","3.90","-4.02","3321","MANVKLFDQTGKEAGEVTLNDAIFGIEPNES","1892055","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:132978): This protein binds directly and specifically to 23S rRNA and belongs to the L4P family of ribosomal proteins.","50S ribosomal protein L4, N-terminal fragment","Cytoplasm, Extracellular","Few weak matches in gapped BLAST to the N-terminal portion of 50S Ribosomal protein L4; residues 1-31 are 83% similar to 50S Ribosomal protein L4 of Streptococcus pneumoniae (gi15900146); residues 1-31 are 87% similar to 50S Ribosomal protein L4 of Streptococcus pyogenes (gi15674288).See Spy0050.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0059 (3e-10).","

InterPro
IPR002136
Family

Ribosomal protein L4/L1e
SSF52166	$\"[2-30]T$	Ribosomal_L4/L1E

","BeTs to 3 clades of COG0088COG name: Ribosomal protein L4Functional Class: JThe phylogenetic pattern of COG0088 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 10:25:56 2006","Wed Jan 9 12:22:31 2002","Thu Feb 9 10:04:39 2006","Tue Jan 8 17:33:54 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1839 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 12:10:31 2002","","No significant hits to the NCBI PDB database.","SMU.2024c","","No significant hits to the Pfam 11.0 database","Tue Jan 8 17:33:54 2002","24380366","","","Herwig,S., Kruft,V. and Wittmann-Liebold,B. Primary structures of ribosomal proteins L3 and L4 from Bacillus stearothermophilus. Eur. J. Biochem. 207 (3), 877-885 (1992) PubMed: 1499563.","","Sat Oct 19 08:57:18 2002","1","","","SMU.2024c","1026" "SMu1840","1892785","1892159","627","ATGACAAAAGGAATCTTAGGGAAAAAAGTGGGAATGACTCAAATCTTCACTGAATCTGGTGAATTTATCCCTGTTACTGTCATCGAAGCAACTCCAAATGTTGTGCTTCAAGTTAAGACTGTTGAAACAGACGGTTACGAAGCAGTTCAAGTTGGCTTTGATGATAAACGTGAAGTATTGAGCAACAAACCTGCCAAAGGCCATGTGGCAAAAGCCGACACAGCTCCTAAGCGCTTCATTCGTGAATTTAAAAACATTGAAGGCTTAGAAGTTGGACAAGAAATTACAGTCGAACAATTCGAGGCTGGTGATGTTGTTGATGTTACTGGTACAACTAAAGGTAAAGGTTTCCAAGGTGCTATTAAACGCCATGGTCAATCACGTGGCCCTATGGCTCATGGTTCTCGTTATCACCGCCGTCCAGGTTCAATGGGACCTGTAGCACCTAACCGTGTATTCAAAGGTAAAAACCTTGCTGGACGTATGGGAGGTAACCGCGTAACGGTTCAAAACCTTGAAGTCGTTCAAGTTGTTCCAGAAAAAAATGTTATCCTTATCAAGGGTAATGTGCCAGGTGCTAAGAAATCTCTTATCATCATCAAATCAGCAGTTAAAGCTGCTAAATAA","10.80","13.96","22368","MTKGILGKKVGMTQIFTESGEFIPVTVIEATPNVVLQVKTVETDGYEAVQVGFDDKREVLSNKPAKGHVAKADTAPKRFIREFKNIEGLEVGQEITVEQFEAGDVVDVTGTTKGKGFQGAIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKGKNLAGRMGGNRVTVQNLEVVQVVPEKNVILIKGNVPGAKKSLIIIKSAVKAAK","1892175","For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28); SMu1839 (rl4);SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).From GenBank (gi:1710556): In B.subtilis, this protein binds directly to 23S rRNA and may participate in the formation of the peptidyltransferase center of the ribosome. It belongs to the L3P family of ribosomal proteins. ","50S ribosomal protein L3","Cytoplasm, Extracellular","Many strong matches in gapped BLAST to 50S ribosomal protein L3; residues 1-208 are 88% similar to 50S ribosomal protein L3 of Streptococcus pyogenes (gi15674287); residues 1-208 are 87% similar to 50S ribosomal protein L3 of Streptococcus pneumoniae (gi15900145).See Spy0049.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0058 (1e-104).","

InterPro
IPR000597
Family

Ribosomal protein L3
PD001374	$\"[112-163]T$	Ribosomal_L3
PF00297	$\"[9-201]T$	Ribosomal_L3
PS00474	$\"[100-123]T$	RIBOSOMAL_L3

InterPro
IPR009000
Domain

Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447	$\"[1-205]T$	Translat_factor

noIPR
unintegrated

unintegrated
PTHR11229	$\"[1-207]T$	PTHR11229

","BeTs to 17 clades of COG0087COG name: Ribosomal protein L3Functional Class: JThe phylogenetic pattern of COG0087 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000597 (Ribosomal protein L3) with a combined E-value of 5.9e-23. IPB000597 98-134","Residues 8-192 are 78% similar to a (RIBOSOMAL 50S RRNA-BINDING PROTEOME COMPLETE CHLOROPLAST) protein domain (PD001374) which is seen in Q9CDW2_LACLA.Residues 90-208 are 32% similar to a (RIBOSOMAL 60S 50S L3P MULTIGENE FAMILY PROTEOME COMPLETE) protein domain (PD004346) which is seen in RL3_ARCFU.Residues 5-110 are 36% similar to a (RIBOSOMAL 50S RRNA-BINDING) protein domain (PD334460) which is seen in RL3_CHLPN.Residues 4-71 are 73% similar to a (RIBOSOMAL 50S RRNA-BINDING CHLOROPLAST) protein domain (PD347954) which is seen in RL3_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Feb 9 10:03:28 2006","Wed Jan 9 11:15:48 2002","Thu Feb 9 09:56:40 2006","Wed Jan 9 11:15:48 2002","Wed Jan 9 11:15:48 2002","Wed Jan 9 11:15:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1840 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 9 15:19:39 2002","","No significant hits to the NCBI PDB database.","SMU.2025c","","Residues 9 to 201 (E-value = 2.2e-90) place SMu1840 in the Ribosomal_L3 family which is described as Ribosomal protein L3 (PF00297)","Wed Jan 9 11:15:48 2002","","","","Takami,H., Takaki,Y., Nakasone,K., Hirama,C., Inoue,A. and Horikoshi,K. Sequence analysis of a 32-kb region including the major ribosomal protein gene clusters from alkaliphilic Bacillus sp. strain C-125. Biosci. Biotechnol. Biochem. 63 (2), 452-455 (1999) PubMed: 10192928.Herwig,S., Kruft,V. and Wittmann-Liebold,B. Primary structures of ribosomal proteins L3 and L4 from Bacillus stearothermophilus. Eur. J. Biochem. 207 (3), 877-885 (1992) PubMed: 1499563.","","Wed Jan 9 11:15:48 2002","1","","","SMU.2025c","225" "SMu1841","1893130","1893020","111","ATGCGTACTCACAAACGTCTGATTGATATTGTGAACCCAACGCAAAAGACAGTTGATGCGCTTATGAAGCTTGATCTTCCAAGTGGTGTAAACGTAGAGATTAAACTTTAA","10.30","2.22","4070","MRTHKRLIDIVNPTQKTVDALMKLDLPSGVNVEIKL","1893036","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu1937 (rpsD);SMu0788 (rpsP); SMu1838 (rps19);SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).Note: Check start codon to see if the 66 amino acid residues preceding the current start are similar to those residues of similar proteins.","30S ribosomal protein S10 fragment","Cytoplasm, Extracellular","This protein is identical to the C-terminal portion of a peviously sequenced protein, 30S ribosomal protein S10 (gi1350920), submitted by Kuramitsu,H.K. and Shibata,Y.Many weak matches in gapped BLAST to the C-terminal portion of 30S ribosomal protein S10; residues 1-36 are 100% similar to the C-terminal portion of 30S ribosomal protein S10 of Streptococcus pneumoniae (gi17865583); residues 1-36 are 94% similar to 30S ribosomal protein S10 of Streptococcus pyogenes (gi17865589).See Spy0047.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0057 (2e-15).","

InterPro
IPR001848
Family

Ribosomal protein S10
PD001272	$\"[1-35]T$	RS10_STRPN_Q97SV6;
G3DSA:3.30.70.600	$\"[1-35]T$	no description
PTHR11700	$\"[1-36]T$	30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER
PF00338	$\"[1-34]T$	Ribosomal_S10

InterPro
IPR005731
Family

Ribosomal protein S10, bacterial form
PTHR11700:SF2	$\"[1-36]T$	30S RIBOSOMAL PROTEIN S10

","BeTs to 17 clades of COG0051COG name: Ribosomal protein S10Functional Class: JThe phylogenetic pattern of COG0051 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Aug 30 15:07:21 2006","Tue Jan 8 17:30:06 2002","Thu Feb 9 09:49:10 2006","Tue Jan 8 17:30:06 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1841 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 14:52:31 2002","Thu Feb 9 09:49:10 2006","pdb1FJFJ Chain J, Structure Of The Thermus Thermophilus 30s R... 70 4e-014","SMU.2026c","","No significant hits to the Pfam 11.0 database","Tue Jan 8 17:30:06 2002","24380368","","","","","","1","","","SMU.2026c","995" "SMu1842","1893648","1894334","687","ATGTTTTCAAGTCAAAAATTAAAAGAAAGACGAAAAAAACTTGGTCTTTCGCAAGCACAAACAGCTGATAAATTAGGAATTAGCCGACCTTCTTATTTTAACTGGGAAATTGGCAAAACAAAGCCAAATCAAAAAAACTTAGATAAATTGGCTCACTTATTAAAGGTTGATTCTGCTTACTTTTTATCACAGCACGATATTGTCGAAATTTATACCCGTTTGAATGAAAGCAATAAAACTAAAACCTTAAAATACTCACAGTATTTACTAGAACAACAAGATAAGGAAAGGAATCTAATGAAAAATAAACGTTATCCCTACAGAGTTTACGAAAAATTATCAGCAGGCACAGGCTATTCCTATTTTGGTGATGGCAATTTTGATACCGTTTTTTATGACGAAGAAATTGATCACGATTTTGCGTCTTGGATCTTTGGAGATTCAATGGAACCTATTTTTCTCAATGGTGAAGTTGCCCTTATTAAACAAACAGGATTTGATTATGATGGCGCCATTTATGCGATTGATTGGGATGGACAAACCTATATAAAAAAGGTCTACCGTGAAGAAACGGGCCTTCGTCTTGTTTCTCTCAACAAGAAATACGCTGATAAATTTGCTCCTTATGATGAAAATCCTCGAATCATTGGATTAATTGTAGGAAATTTTATCCCCCTTGAAGGCTAA","8.80","1.73","26545","MFSSQKLKERRKKLGLSQAQTADKLGISRPSYFNWEIGKTKPNQKNLDKLAHLLKVDSAYFLSQHDIVEIYTRLNESNKTKTLKYSQYLLEQQDKERNLMKNKRYPYRVYEKLSAGTGYSYFGDGNFDTVFYDEEIDHDFASWIFGDSMEPIFLNGEVALIKQTGFDYDGAIYAIDWDGQTYIKKVYREETGLRLVSLNKKYADKFAPYDENPRIIGLIVGNFIPLEG","1894346","","transcriptional regulator/repressor","Cytoplasm","Smu1842 is virtually identical to a previously sequenced protein, hypothetical protein 3 (gi79997), submitted by Shiroza,T. and Kuramitsu,H.K.Several strong and many moderate matches in gapped BLAST to transcriptional regulators/repressor proteins; residues 1-227 are 58% similar to putative repressor protein of Streptococcus pyogenes (gi15675164); residues 5-227 are 33% similar to transcriptional regulator of Lactococcus lactis (gi15673253).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1268 (6e-58).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
PF01381	$\"[7-61]T$	HTH_3
SM00530	$\"[6-61]T$	HTH_XRE
PS50943	$\"[7-61]T$	HTH_CROC1

InterPro
IPR006198
Domain

Peptidase S24, S26A and S26B
PF00717	$\"[143-210]T$	Peptidase_S24

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[2-62]T$	Lambda_like_DNA

InterPro
IPR011056
Domain

Peptidase S24 and S26, C-terminal region
G3DSA:2.10.109.10	$\"[137-225]T$	Pept_S24_S26_C
SSF51306	$\"[104-225]T$	Pept_S24_S26_C

noIPR
unintegrated

unintegrated
G3DSA:1.10.260.40	$\"[4-111]T$	G3DSA:1.10.260.40

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 6-62 are identical to a (REPRESSOR COMPLETE PROTEOME) protein domain (PD027337) which is seen in Q54446_STRMU.Residues 138-220 are 39% similar to a (REPRESSOR DNA SOS HYDROLASE) protein domain (PD001529) which is seen in Q9G039_VVVVV.Residues 63-137 are 97% similar to a (MUCA HOMOLOG UMUD) protein domain (PD202258) which is seen in Q54446_STRMU.Residues 138-220 are identical to a (REPRESSOR PROTEOME COMPLETE TRANSCRIPTION) protein domain (PD079968) which is seen in Q54446_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Jan 8 17:20:56 2002","Wed Jul 12 16:07:07 2006","Wed Jul 12 16:07:07 2006","Tue Jan 8 17:20:00 2002","","Tue Jan 8 17:20:00 2002","no","Tue Oct 8 14:34:04 2002","SMu1842 is paralogously related (blast p-value < 1e-3) to SMu1275,a predicted repressor protein - phage associated; SMu0197, SMu0737 and SMu0366, predicted hypothetical protein; possible transcriptional regulator.","Mon Apr 15 09:22:23 2002","","No significant hits to the NCBI PDB database.","SMU.2027","","Residues 7 to 61 (E-value = 3.3e-17) place SMu1842 in the HTH_3 family which is described as Helix-turn-helix (PF01381)","Tue Jan 8 17:20:00 2002","24380369","","Shiroza,T. and Kuramitsu,H.K. Sequence analysis of the Streptococcus mutans fructosyltransferase gene and flanking regions. J. Bacteriol. 170 (2), 810-816 (1988) PubMed: 2828325.","","Mon Apr 15 09:22:23 2002","","1","","","SMU.2027","818" "SMu1843","1896912","1894525","2388","ATGGAAACTAAAGTTAGAAAAAAGATGTATAAGAAAGGGAAATTTTGGGTGGTAGCCACCATCACAACTGCTATGCTGACTGGAATTGGGCTCTCTTCTGTTCAGGCAGATGAAGCCAATTCAACTCAAGTTTCTTCAGAATTGGCTGAAAGAAGTCAGGTTCAAGAAAATACAACTGCTTCATCATCAGCAGCAGAAAATCAGGATAAGACTGAAGTTAAAGAAACACCATCAACAAATCCCGCAGCTGCTACTGTTGAGAATACTGATCAAACAACTAAGGTGATAACAGATAATGCTGCTGTTGAATCAAAAGCCAGTAAAACTAAGGATCAAGCAGCTACCGTAACTAAAACATCAGCTAGTACACCGGAAGTAGGTCAAACAAATGAAAAGGCTAAGGCAACTAAAGAAGCTGACATAACTACGCCAAAGAATACAATAGATGAATACGGTCTAACAGAACAGGCTCGTAAGATTGCGACTGAAGCTGGTATTAATTTAAGCAGTTTGACACAAAAGCAAGTTGAAGCATTAAATAAAGTTAAATTAACGAGTGATGCTCAAACGGGTCATCAAATGACCTATCAAGAATTTGACAAGATTGCTCAAACGTTGATAGCTCAAGATGAACGCTATGCTATCCCTTATTTTAATGCAAAAGCAATCAAAAATATGAAGGCGGCTACAACGCGTGATGCCCAAACGGGTCAAATAGCTGATTTGGATGTTTGGGATTCTTGGCCAGTTCAGGATGCTAAGACTGGTGAAGTTATTAATTGGAATGGTTATCAGCTTGTTGTTGCTATGATGGGCATTCCAAATACTAATGATAATCATATTTATCTTCTTTATAATAAATATGGAGATAATAATTTTGATCATTGGAAAAATGCAGGTTCTATCTTTGGTTATAATGAAACACCCCTAACTCAAGAATGGTCAGGTTCAGCTACCGTAAATGAAGATGGAAGTTTGCAGTTATTCTACACCAAGGTTGATACTAGTGACAAAAACAGTAACAATCAACGTTTAGCAACAGCGACTGTAAATCTTGGCTTTGATGACCAAGATGTTAGAATTCTTTCTGTTGAAAATGATAAAGTTTTAACGCCTGAAGGCGGTGATGGCTATCATTATCAAAGTTATCAACAATGGCGTTCAACCTTTACAGGTGCTGATAATATTGCTATGCGTGATCCACATGTCATTGAAGATGAGAATGGAGATCGCTATCTTGTCTTTGAGGCTAGTACAGGTACAGAGAATTATCAAGGTGAAGATCAGATTTACAACTTTACTAACTATGGCGGCAGCTCTGCTTATAATGTTAAAAGTCTTTTTAGATTTTTAGATGATCAAGATATGTATAACCGTGCAAGCTGGGCCAATGCAGCTATTGGTATTTTAAAACTTAAGGGCGATAAAAAAACACCTGAGGTAGATCAATTTTACACGCCTTTACTAAGTTCAACAATGGTTTCGGATGAACTCGAGCGACCCAATGTGGTTAAATTAGGAGATAAGTACTATCTTTTTACAGCTTCACGTCTTAATCACGGAAGTAACAACGATGCTTGGAATAAAGCAAATGAAGTTGTTGGTGATAATGTCGTTATGCTAGGTTATGTTTCTGATCAATTGACTAACGGCTACAAACCCTTAAATAATAGTGGTGTGGTTTTAACAGCTTCAGTTCCAGCAGATTGGCGAACGGCGACTTACTCTTATTATGCTGTTCCAGTAGCTGGATCATCTGATACCCTGTTAATGACGGCTTATATGACCAATCGTAATGAAGTCGCAGGTAAAGGTAAGAATTCAACCTGGGCACCTAGTTTTCTGATTCAGGTTTTACCAGATGGGACTACAAAAGTCTTAGCAGAAATGACACAACAGGGTGATTGGATTTGGGATGAATCAAGTCGCACGACAGACACTGTTGGCACGCTGGATACAGCCTATCTTCCAGGTGAAAATGATGGTTATATTGATTGGAATGTTATTGGTGGCTACGGTTTGAAGCCACATACACCGGGACAATATCAACCAACTGTTCCATCAACACCAATTCATACAGATGACATTATTTCTTTTGAAGTCTCTTTTGATGGTCATCTCGTTATTAAACCTGTCAAAGTAAATAATGACTCCGCTGGTCGAATTGACCAATCAAGGAATTCAGGTGGGTCTCTTAATGTTGCCTTTAATGTCTATGCGGGCGGAAATATTTCTGTCAAACCTTCTCAAAAATCGATTAATAACACAAAAGAAACAAAGAAAGCTCATCATGTTTCAACAGAAAAGAAACAGAAAAAAGGAAATTCTTTCTTTGCAGCTTTATTAGCTCTTTTCAGTGCTTTCTGTGTAAGCATTGGTTTTAAATAA","5.00","-18.33","87379","METKVRKKMYKKGKFWVVATITTAMLTGIGLSSVQADEANSTQVSSELAERSQVQENTTASSSAAENQDKTEVKETPSTNPAAATVENTDQTTKVITDNAAVESKASKTKDQAATVTKTSASTPEVGQTNEKAKATKEADITTPKNTIDEYGLTEQARKIATEAGINLSSLTQKQVEALNKVKLTSDAQTGHQMTYQEFDKIAQTLIAQDERYAIPYFNAKAIKNMKAATTRDAQTGQIADLDVWDSWPVQDAKTGEVINWNGYQLVVAMMGIPNTNDNHIYLLYNKYGDNNFDHWKNAGSIFGYNETPLTQEWSGSATVNEDGSLQLFYTKVDTSDKNSNNQRLATATVNLGFDDQDVRILSVENDKVLTPEGGDGYHYQSYQQWRSTFTGADNIAMRDPHVIEDENGDRYLVFEASTGTENYQGEDQIYNFTNYGGSSAYNVKSLFRFLDDQDMYNRASWANAAIGILKLKGDKKTPEVDQFYTPLLSSTMVSDELERPNVVKLGDKYYLFTASRLNHGSNNDAWNKANEVVGDNVVMLGYVSDQLTNGYKPLNNSGVVLTASVPADWRTATYSYYAVPVAGSSDTLLMTAYMTNRNEVAGKGKNSTWAPSFLIQVLPDGTTKVLAEMTQQGDWIWDESSRTTDTVGTLDTAYLPGENDGYIDWNVIGGYGLKPHTPGQYQPTVPSTPIHTDDIISFEVSFDGHLVIKPVKVNNDSAGRIDQSRNSGGSLNVAFNVYAGGNISVKPSQKSINNTKETKKAHHVSTEKKQKKGNSFFAALLALFSAFCVSIGFK","1894543","From GenBank (gi:134174): This S.mutans protein catalyzes the reaction: sucrose + (2,6-beta-D-fructosyl)(N) = glucose + (2,6-beta-D-fructosyl)(N+1) (other sugars can also acts as fructosyl acceptors). It is secreted and belongs to family 68 of glycosyl hydrolases.","fructosyltransferase ","Extracellular","This protein is virtually identical to a previously sequenced protein, levansucrase (gi134174), submitted by .Many strong matches in gapped BLAST to levansucrase; residues 18-678 are 48% similar to levansucrase of Streptococcus salivarius (gi3914956); residues 209-634 are 41% similar to levansucrase of Bacillus amyloliquefaciens (gi134172).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1206 (1e-11).","

InterPro
IPR003469
Family

Glycoside hydrolase, family 68
PF02435	$\"[184-637]T$	Glyco_hydro_68

noIPR
unintegrated

unintegrated
SSF75005	$\"[182-640]T$	SSF75005

","No hits to the COGs database.","***** IPB003469 (Levansucrase/Invertase) with a combined E-value of 1.1e-30. IPB003469A 408-424 IPB003469B 482-517***** IPB003318 (Glucosyltransferase S precursor) with a combined E-value of 1e-07. IPB003318A 1-19","Residues 2-86 are 97% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002249) which is seen in SACB_STRMU.Residues 19-213 are 23% similar to a (GP7) protein domain (PD325028) which is seen in Q9G0H8_VVVVV.Residues 679-795 are 88% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD291575) which is seen in SACB_STRMU.Residues 579-678 are 99% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD042476) which is seen in SACB_STRMU.Residues 92-218 are 97% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD042477) which is seen in SACB_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 09:26:34 2002","Tue Apr 3 14:45:50 2007","Thu Feb 3 14:39:51 2005","Tue Jan 8 16:57:34 2002","Tue Jan 8 16:57:34 2002","Tue Jan 8 16:57:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1843 is paralogously related (blast p-value < 1e-3) to SMu0827, a predicted glucosyltransferase-S; SMu0915, a predicted glucosyltransferase-SI; SMu0914, a predicted glucosyltransferase-I ; SMu0897, a predicted wall-associated protein A precursor; SMu0555,a predicted 40K cell wall protein precursor (sr 5' region); choline binding protein D; SMu1947 and SMu0057 , both predicted conserved hypothetical proteins; SMu0070,a predicted fructan hydrolase; exo-beta-D-fructosidase and SMu0556, a predicted cell surface antigen I/II, SpaP protein precursor, pac protein precursor; saliva-interacting protein;PAGS-5.","Tue Apr 3 14:45:50 2007","","No significant hits to the NCBI PDB database.","SMU.2028c","","Residues 184 to 637 (E-value = 1.5e-273) place SMu1843 in the Glyco_hydro_68 family which is described as Levansucrase/Invertase (PF02435)","Tue Jan 8 16:57:34 2002","",""," Shemesh M, Tam A, Feldman M, Steinberg D.,Differential expression profiles of Streptococcus mutans ftf, gtf and vicR genes in the presence of dietary carbohydrates at early and late exponential growth phases.Carbohydr Res. 2006 Sep 4;341(12):2090-7. Epub 2006 Jun 9.PMID: 16764842Rozen R, Bachrach G, Steinberg D.Effect of carbohydrates on fructosyltransferase expression and distribution in Streptococcus mutans GS-5 biofilms.Carbohydr Res. 2004 Dec;339(18):2883-8.PMID: 15582615Bronshteyn M, Steinberg D.Immobilization of fructosyltransferase from Streptococcus mutans on hydroxyapatite surfaces induces the formation of multimeric complexes.Lett Appl Microbiol. 2002;34(3):205-9.PMID: 11874543Shiroza,T. and Kuramitsu,H.K.,Sequence analysis of the Streptococcus mutans fructosyltransferase gene and flanking regions.J. Bacteriol. 170 (2), 810-816 (1988)PubMed: 2828325","","Tue Apr 3 14:45:25 2007","Mon Apr 15 09:26:34 2002","1","","","SMU.2028c","" "SMu1844","1899640","1897199","2442","ATGACCGATTACTCATTAAAAATGCAGGAAGTCTTTCGATTGGCGCAGTTTGAAGCAGCTCGTTTTGAAAGTTCCTATTTAGAAAGCTGGCATGTCCTTCTTGCAATGGTAGAGATTGATTCCTCAGTGGCTGGTTTAAGTTTTGCGGAGTTTGAAGCAGATGTCCGTTTTGAGGATTATCAGGCTGCTGCTATTTTGGCGATTGGTAAAAAGCCTAAGTCCTCGAGTAATGATATTATGCTTTTAGAGCAATCACATGCTTTAAAACGAACCCTAGCAGAGGCCGCTGCTATTAGTCAGGTGACACACGCTAAAGAAGTCGGCACAGAACATGTTCTCTTTGCTATGTTACTGAATCCTAATCTTTTGGCGACTCGCATTTTAGAATTAGTTGGTTTTCACGCCAAAGATGATGGAGAGTCCATCCGTCTTTTGGATCTGCGAAAAGTGATTGAACGTTATGCTGGCTTTTCCAAAGAGGACATTAAGGCCATCTTTGAAATGCGTAAACCTAAAAAGGTCAAAAATAGCAGCAGCTTTTCTGATTTAATGAAGCCACCTAGCGTTACAGGTGAACTAGCTGATTTTACACGGGATTTGACGGAGTTGGCAAGACAAGGTCGTTTAGAACCTGTTATTGGCCGTGAACAAGAAATTTCACGGATGGTTCAAATTTTAAGCCGTAAGACAAAAAATAACCCTGTTTTAGTTGGCGATGCTGGTGTTGGGAAGACGGCCTTGGCTTACGGCCTTGCTCAACGTATTGTGGATAGTGCCGTTCCTTTTGAATTGGCAGATATGAAAGTACTAGAGCTCGATATGATGAGTGTTGTTGCAGGGACTCGTTTTCGTGGCGATTTTGAGGAACGAATGAATCAAATTATTGCAGACATTGAAGCAGATGGTCACATTGTCCTCTTCATTGATGAGCTGCATACCATTATGGGTTCAGGAAGTGGTATTGATAGTACGCTGGATGCTGCTAATATTCTTAAACCAGCTTTAGCGCGCGGCAGTCTTAGAACGATTGGAGCGACTACTCAAGAGGAGTATCAAAAGCATATTGAAAAAGATGCTGCTCTTTCTCGCCGTTTTGCTAAGGTAACTATTGAAGAACCAAGTGAAGAAGAAGCTTATCAGATCTTGCTTGGTTTAAAGAAAAGTTATGAAACTTATCATCATGTTATTATTTCTGATGCAGCCGTAATGGCGGCAGTCAAAGGAGCACATCGTTATTTAAGTGGTAAAAATTTACCTGATTCGGCTATCGATCTTTTAGATGAAGCTAGTGCAACTGTTCAAGGCTTAGTGAAAAAAAAGGCACCAGCTTATTTGACAGATTTAGATCATGCTCTTATCACTAACGATTACCAATTAGCTAAGCGTTTGCTGAAAAAGGAGAAGAAGCCTCTACTTAAAAAACGAGCTGAAGTCAAGGAAGAAGATATCCTAGCTACTCTCAGCAAACTTTCAGGCATCCCTGTCAAAAAATTAACACAGGCTGACAGTAAAAAGTACCTTAATCTCGAAAGGGAATTACATAAGCGTGTAATTGGTCAAGACGATGCGGTGTCCAGTATCAGCCGTGCTATTCGCCGCAATCAATCCGGAATTCGGGTTGGCAAACGTCCCATTGGCTCTTTCATGTTTTTGGGGCCGACAGGTGTTGGTAAAACAGAGCTTGCTAAGGCTTTGGCAGAAGTGCTTTTTGATGATGAGTCAGCTCTTATTCGTTTTGACATGAGCGAATATATGGAAAAATTTGCAGCTTCTCGCCTTAATGGAGCTCCTCCGGGCTATGTGGGGTATGAAGAAGGCGGTGAGTTGACGGAAAAGGTTCGTAACAAACCTTACTCTGTTCTTCTTTTTGATGAGGTGGAAAAAGCTCATCCAGATATTTTCAATATCTTACTTCAAGTACTTGATGATGGTGTTTTGACAGATAGCCGTGGTCGCAAAGTTGATTTTTCAAATACGATTATTATCATGACCTCTAATTTGGGTGCGACTGCGCTTCGTGATGATAAAACCGTTGGTTTTGGAGCTAAAAGCTTTTCCCAGGATTATAAGGCCATGGAAAGTCGTATTTTAGAGGAATTAAAAAAGGTTTACCGACCTGAATTTATTAATCGTATTGATGAAAAAGTTGTCTTTCATAACCTTGGTCAAGAAGACATACGCCATATTGTTAAAATTATGGTTGCTCCATTGATTGCCCATTTGGCTGATCAGGGGATTACACTTAAGTTTCAGCCTTCAGCTTTGAAACATTTAGCTCTGGCAGGTTATGATGCTGAAATGGGGGCACGTCCTTTGCGTCGGACACTTCAGACAGAAGTGGAAGATAAGTTAGCAGAGCTTATTCTTTCGGGAAAACTAGCCAGTGGACAGACTCTGAAAATAGGTATTCAAAAAGAAAAATTAAAATTTGATATTGTATAA","6.90","-0.56","90325","MTDYSLKMQEVFRLAQFEAARFESSYLESWHVLLAMVEIDSSVAGLSFAEFEADVRFEDYQAAAILAIGKKPKSSSNDIMLLEQSHALKRTLAEAAAISQVTHAKEVGTEHVLFAMLLNPNLLATRILELVGFHAKDDGESIRLLDLRKVIERYAGFSKEDIKAIFEMRKPKKVKNSSSFSDLMKPPSVTGELADFTRDLTELARQGRLEPVIGREQEISRMVQILSRKTKNNPVLVGDAGVGKTALAYGLAQRIVDSAVPFELADMKVLELDMMSVVAGTRFRGDFEERMNQIIADIEADGHIVLFIDELHTIMGSGSGIDSTLDAANILKPALARGSLRTIGATTQEEYQKHIEKDAALSRRFAKVTIEEPSEEEAYQILLGLKKSYETYHHVIISDAAVMAAVKGAHRYLSGKNLPDSAIDLLDEASATVQGLVKKKAPAYLTDLDHALITNDYQLAKRLLKKEKKPLLKKRAEVKEEDILATLSKLSGIPVKKLTQADSKKYLNLERELHKRVIGQDDAVSSISRAIRRNQSGIRVGKRPIGSFMFLGPTGVGKTELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNILLQVLDDGVLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKSFSQDYKAMESRILEELKKVYRPEFINRIDEKVVFHNLGQEDIRHIVKIMVAPLIAHLADQGITLKFQPSALKHLALAGYDAEMGARPLRRTLQTEVEDKLAELILSGKLASGQTLKIGIQKEKLKFDIV","1897217","For other 'clp' genes see SMu0511 (clpE); SMu0861 (clpX) ; SMu0868 (clpE), (clpL); SMu1524 (clpP) and SMu1300 (clpB).For ATP-dependent Clp protease subunit X see SMu0861. For ATP-dependent Clp protease, ATP-binding subunit see SMu0868. For ATP-dependent Clp protease,ATP-binding subunit ClpB see SMu1300. For ATP-dependent Clp protease, proteolytic subunit see SMu1524. From GenBank (gi:586900): In B.subtilis, this protein functions as a competence gene repressor, required for cell growth at high temperature. It is a negative regulator of ComK expression and may interact with MecA to negatively regulate ComK. It belongs to the ClpA/ClpB family; ClpC subfamily.","ATP-dependent Clp protease, ATP-binding subunit (Class III stress response-related ATPase)","Cytoplasm","Numerous strong matches in gapped BLAST to Class III stress response-related ATPase protein ClpC; residues 1-812 are 72% similar to endopeptidase Clp ATP-binding chain C of Streptococcus pyogenes (gi15675834); residues 3-812 are 64% similar to ATP-dependent Clp protease, ATP-binding subunit of Streptococcus pneumoniae (gi15902001).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1828 (0.0).","

InterPro
IPR001270
Family

Chaperonin clpA/B
PR00300	$\"[548-566]T$ $\"[593-611]T$ $\"[622-640]T$ $\"[655-669]T$	CLPPROTEASEA
PS00870	$\"[326-338]T$	CLPAB_1
PS00871	$\"[578-596]?$	CLPAB_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[230-375]T$ $\"[544-684]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[233-382]T$	AAA

InterPro
IPR004176
Domain

Clp, N-terminal
PF02861	$\"[15-69]T$ $\"[95-156]T$	Clp_N

InterPro
IPR013093
Domain

ATPase AAA-2
PF07724	$\"[543-715]T$	AAA_2

noIPR
unintegrated

unintegrated
G3DSA:1.10.1780.10	$\"[3-159]T$	G3DSA:1.10.1780.10
G3DSA:1.10.8.60	$\"[721-810]T$	G3DSA:1.10.8.60
G3DSA:3.40.50.300	$\"[189-383]T$ $\"[496-720]T$	G3DSA:3.40.50.300
PTHR11638	$\"[4-645]T$	PTHR11638
PTHR11638:SF19	$\"[4-645]T$	PTHR11638:SF19
SSF81923	$\"[2-161]T$	SSF81923

","BeTs to 14 clades of COG0542COG name: ATPases with chaperone activity, ATP-binding domainFunctional Class: OThe phylogenetic pattern of COG0542 is --t-YQVCEBRhUJgpOLINxNumber of proteins in this genome belonging to this COG is 4","***** IPB001270 (Chaperonins clpA/B) with a combined E-value of 5.5e-193. IPB001270A 212-254 IPB001270B 255-303 IPB001270C 304-318 IPB001270D 345-399 IPB001270E 524-578 IPB001270F 605-659 IPB001270G 704-718 IPB001270H 762-776 IPB001270E 210-264","Residues 260-312 are 52% similar to a (PROTEASE ATP-BINDING SHOCK HEAT COMPLETE PROTEOME) protein domain (PD187342) which is seen in CLPC_BACSU.Residues 190-234 are 51% similar to a (PROTEASE ATP-BINDING PROTEOME COMPLETE) protein domain (PD251998) which is seen in Q9JV15_NEIMA.Residues 478-796 are 51% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9PQ99_UREPA.Residues 343-420 are 56% similar to a (PROTEASE ATP-BINDING PROTEOME COMPLETE ATP-DEPENDENT) protein domain (PD001382) which is seen in Q9HVN5_PSEAE.Residues 543-646 are 66% similar to a (COMPLETE PROTEOME SECRETION TYPE PLASMID ATP-BINDING) protein domain (PD000739) which is seen in CLPB_HELPJ.Residues 478-536 are 49% similar to a (COIL COILED MYOSIN CHAIN ATP-BINDING HEAVY FILAMENT) protein domain (PD000002) which is seen in CLPB_SYNY3.Residues 144-257 are 48% similar to a (PROTEASE ATP-BINDING COMPLETE SHOCK HEAT PROTEOME) protein domain (PD002024) which is seen in Q9ZIL9_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 09:51:56 2006","Tue Jan 8 16:36:58 2002","Thu Aug 24 09:51:56 2006","Tue Jan 8 16:36:58 2002","Tue Jan 8 16:36:58 2002","Tue Jan 8 16:36:58 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1844 is paralogously related (blast p-value < 1e-3) to SMu0511, a predicted ATP-dependent protease ClpE; SMu0868,a predicted ATP-dependent Clp protease, ATP-binding subunit; SMu1300,a predicted ATP-dependent Clp protease, ATP-binding subunit ClpB; SMu0861,a predicted ATP-dependent Clp protease subunit X and SMu1866, a predicted chromosome segregation helicase (ATPase related to the helicase subunit of the Holliday junction resolvase).","Mon Apr 15 09:30:32 2002","","No significant hits to the NCBI PDB database.","SMU.2029c","","Residues 233 to 427 (E-value = 2e-08) place SMu1844 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)","Tue Jan 8 16:36:58 2002","","","Lemos JA, Burne RA. Regulation and Physiological Significance of ClpC and ClpP in Streptococcusmutans.J Bacteriol. 2002 Nov 15;184(22):6357-6366.PMID: 12399506 ","Ingmer,H., Vogensen,F.K., Hammer,K. and Kilstrup,M. Disruption and analysis of the clpB, clpC, and clpE genes in Lactococcus lactis: ClpE, a new clp family in gram-positive bacteria. J. Bacteriol. 181 (7), 2075-2083 (1999) PubMed: 10094684.Kruger,E., Volker,U. and Hecker,M. Stress induction of clpC in Bacillus subtilis and its involvement in stress tolerance. J. Bacteriol. 176 (11), 3360-3367 (1994) PubMed: 8195092.","Thu Aug 24 09:51:56 2006","Tue Jan 8 16:40:55 2002","1","","","SMU.2029c","187" "SMu1845","1900101","1899637","465","ATGACGTCAAAAAATACTTCAGACAGTATTGAAGAATATATTAAAAAAATCTTAGCACAGTCGGGCTTCGCGGAAATCAAAAGAAGTGTTCTGGCAGATAATTTTAGTGTTGTTCCCAGTCAGATTAATTATGTCATTAAGACGCGTTTCACAGAGAGCCGTGGTTATGCCGTTGAGAGCAAACGTGGTGGTGGCGGTTATATTAGGATTGCTAAAATCCGTTTTTCAGACCAACACCAGATGCTCAATGATTTAGAAGCGACTATTGGTGAACAAATTAGCGAGCAAGTTTTTACAGATATTATTCAACTTCTCTTTGATGAGAAAATTATTAGCGAGCGTGAAGGGAATATTATTTTGGCGAGTTCAGGAGATGATGTTCTTGGAGAAGAGAGCTCTCGAATTCGTGCCCGTATGCTTCGCAAAATATTACAACGTTTAGATAGAAAAGGATACCATCTATGA","9.10","1.48","17486","MTSKNTSDSIEEYIKKILAQSGFAEIKRSVLADNFSVVPSQINYVIKTRFTESRGYAVESKRGGGGYIRIAKIRFSDQHQMLNDLEATIGEQISEQVFTDIIQLLFDEKIISEREGNIILASSGDDVLGEESSRIRARMLRKILQRLDRKGYHL","1899655","From GenBank (gi:15672623): In Lactococcus lactis, this protein is a regulator of class III stress genes (clpC, clpP).","transcriptional regulator of class III stress genes, CtsR","Cytoplasm, Membrane","Several moderate matches in gapped BLAST to transctiptional regulators; residues 1-151 are 74% similar to transctiptional regulator of Streptococcus pyogenes (gi|15675835); residues 1-151 are 59% similar to transctiptional regulator, CtsR, of Streptococcus pneumoniae (gi|15904042).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1829 (2e-66).","

InterPro
IPR008463
Family

Firmicute transcriptional repressor of class III stress genes
PIRSF010607	$\"[3-151]T$	Txn_repr_CtsR
PF05848	$\"[3-149]T$	CtsR

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-149 are 52% similar to a (CTSR REPRESSOR PROTEOME COMPLETE) protein domain (PD033972) which is seen in Q9CHT0_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 08:23:48 2002","Tue Oct 15 08:23:48 2002","Tue Oct 15 08:23:48 2002","Tue Jan 8 16:24:50 2002","","Tue Jan 8 16:24:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1845 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 16:26:27 2002","","No significant hits to the NCBI PDB database.","SMU.2030c","","Residues 3 to 149 (E-value = 5.6e-86) place SMu1845 in the CtsR family which is described as Firmicute transcriptional repressor of class III stress genes (CtsR) (PF05848)","Tue Jan 8 16:24:50 2002","","","","","","","1","","","SMU.2030c","860" "SMu1846","1901428","1900382","1047","ATGGCAAATATTACTGCAGCTCTTGTTAAGGAATTGCGTGAAAAAACTGGTGCTGGTGTCATGGACGCCAAAAAAGCCTTGGTTGAAGTTGAAGGCGATATGGGAAAAGCAATTGAACTTCTTCGCGAAAAAGGTATGGCCAAAGCAGCTAAAAAAGCTGACCGTGTTGCCGCTGAAGGTTTAACAGGTGTTTATGTTGATGGCAATGTTGCCGCTATTGTGGAAGTTAATGCCGAAACCGATTTTGTTGCTAAAAATGCTCAATTTGTTGACTTAGTCAATGAAACAGCTAAAGTTATCGCTGAAGGTAAACCTGCTAACAATGAAGAAGCCCTTGCTTTAAAAACAGCAGCTGGAGATACTTTAGAGGCTGCTTATGTCAATGCAACAGCAACCATTGGAGAAAAAATTTCTTTCCGCCGTTTTGCTCTTGTTGAGAAAGCTGATAAACAAGTTTTCGGTGCCTACCAGCATAATGGTGGTAAGATTGGCGTTATCACGGTCCTTGAAGGTGAAAATACGGATGAAGCTCTTGCCAAACAACTTGCCATGCATGTTGCTGCAATGAACCCAAGTGTTCTTTCATACAAAGAATTGAGCGAAGAATTTATTCATGATGAATTGGCTCAAATGAACCATAAAATTGAACAAGATAATGAAAGCCGTGCTATGGTTGATAAACCAGCTCTTCCGCTTCTTAAATACGGTTCAAAAGGTCAATTAACTGATGAAGTCGTTGCTCAAGCTGAAGAAGATATCAAGGCAGAGCTTAAAGCTGAAGGCAAACCTGAAAAAATTTGGGATAAAATCATTCCTGGTAAAATGGCTCGCTTCTTCTTGGACAATACGAAGGTTGACCAACAATATACTTTGTTATCACAAGTTTACATTATGGATGACAGTAAGACTGTTGAAGCTTATATGGAATCCGTAAATGGGAAAGTGATTAGCTTTGTTCGTTTTGAGGTCGGCGAAGGTATTGAAAAAGCAGCTAACGATTTTGAAAATGAAGTTGCTGCAACCATGGCAGCTGCTCTTAATAAATAA","4.70","-14.99","37707","MANITAALVKELREKTGAGVMDAKKALVEVEGDMGKAIELLREKGMAKAAKKADRVAAEGLTGVYVDGNVAAIVEVNAETDFVAKNAQFVDLVNETAKVIAEGKPANNEEALALKTAAGDTLEAAYVNATATIGEKISFRRFALVEKADKQVFGAYQHNGGKIGVITVLEGENTDEALAKQLAMHVAAMNPSVLSYKELSEEFIHDELAQMNHKIEQDNESRAMVDKPALPLLKYGSKGQLTDEVVAQAEEDIKAELKAEGKPEKIWDKIIPGKMARFFLDNTKVDQQYTLLSQVYIMDDSKTVEAYMESVNGKVISFVRFEVGEGIEKAANDFENEVAATMAAALNK","1900400","From GenBank (gi:13878479): In Lactococcus lactis, EF-TS associates with EF-TU - GDP complex and induces the exchange of GDP to GTP. This cytoplasmic protein remains bound to the aminoacyl-tRNA-EF-TU-GTP complex up until the GTP is hydrolysed on the ribosome. It belongs to the EF-TS family.","translation elongation factor Ts","Cytoplasm","Many strong matches in gapped BLAST to translation elongation factor Ts; residues 1-347 are 78% similar to translation elongation factor Ts of Streptococcus pyogenes (gi15675850); residues 1-347 are 80% similar to translation elongation factor Ts of Streptococcus pneumoniae (gi15904060).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1831 (1e-156).","

InterPro
IPR000449
Domain

Ubiquitin-associated/Translation elongation factor EF1B, N-terminal
PF00627	$\"[4-44]T$	UBA

InterPro
IPR001816
Family

Translation elongation factor EFTs/EF1B
PTHR11741	$\"[7-215]T$ $\"[234-340]T$	Transl_elong_EFTs/EF1B
TIGR00116	$\"[1-344]T$	tsf
PS01126	$\"[12-27]T$	EF_TS_1
PS01127	$\"[75-85]T$	EF_TS_2

InterPro
IPR009060
Domain

UBA-like
SSF46934	$\"[2-55]T$	UBA_like

InterPro
IPR014039
Domain

Translation elongation factor EFTs/EF1B, dimerisation
PF00889	$\"[57-325]T$	EF_TS
SSF54713	$\"[57-325]T$	EF_TS

noIPR
unintegrated

unintegrated
G3DSA:1.10.8.30	$\"[2-55]T$	G3DSA:1.10.8.30
G3DSA:3.30.479.20	$\"[57-146]T$ $\"[152-324]T$	G3DSA:3.30.479.20

","BeTs to 12 clades of COG0264COG name: Translation elongation factor TsFunctional Class: JThe phylogenetic pattern of COG0264 is -----qvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001816 (Elongation factor Ts) with a combined E-value of 1.1e-72. IPB001816A 9-55 IPB001816B 73-89 IPB001816C 130-143 IPB001816D 180-205 IPB001816E 261-290","Residues 235-325 are 32% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD355203) which is seen in Q9KA64_BACHD.Residues 8-200 are 24% similar to a (FACTOR TS ELONGATION) protein domain (PD208645) which is seen in O97235_PLAFA.Residues 11-97 are 66% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD002210) which is seen in EFTS_LACLA.Residues 140-231 are 67% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD106461) which is seen in EFTS_LACLA.Residues 123-191 are 57% similar to a (FACTOR ELONGATION BIOSYNTHESIS EF-TS) protein domain (PD249321) which is seen in EFTS_BACSU.Residues 237-329 are 72% similar to a (ELONGATION FACTOR EF-TS BIOSYNTHESIS) protein domain (PD337039) which is seen in EFTS_LACLA.Residues 118-191 are 38% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD248236) which is seen in EFTS_RICPR.Residues 98-139 are 71% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD375058) which is seen in EFTS_LACLA.Residues 132-191 are 43% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD406595) which is seen in EFTS_CHLPN.Residues 1-96 are 43% similar to a (FACTOR ELONGATION EF-TS BIOSYNTHESIS) protein domain (PD395995) which is seen in EFTS_PSEAE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 08:22:41 2002","Tue Jan 8 16:15:34 2002","Tue Sep 19 15:35:19 2006","Tue Jan 8 16:15:34 2002","Tue Jan 8 16:15:34 2002","Tue Jan 8 16:15:34 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1846 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 16:19:25 2002","Tue Sep 19 15:35:19 2006","pdb1EFUB Chain B, Elongation Factor Complex Ef-TuEF-Ts From E... 177 1e-045pdb1AIPC Chain C, Ef-Tu Ef-Ts Complex From Thermus Thermophil... 80 3e-016","SMU.2031c","","Residues 4 to 44 (E-value = 5.9e-09) place SMu1846 in the UBA family which is described as UBA/TS-N domain (PF00627)Residues 57 to 325 (E-value = 7.1e-79) place SMu1846 in the EF_TS family which is described as Elongation factor TS (PF00889)","Tue Sep 19 15:35:19 2006","","","","Schmid,R., Bernhardt,J., Antelmann,H., Volker,A., Mach,H., Volker,U. and Hecker,M. Identification of vegetative proteins for a two-dimensional protein index of Bacillus subtilis. Microbiology 143 (Pt 3), 991-998 (1997) PubMed: 9084183.","","Tue Jan 8 16:19:25 2002","1","","","SMU.2031c","482" "SMu1847","1902280","1901495","786","ATGGCAGTTATTTCAATGAAACAACTCCTCGAGGCTGGTGTGCACTTTGGTCACCAAACGCGTCGTTGGAATCCTAAGATGGCTAAGTACATCTTCACAGAACGTAATGGAATTCACGTTATTGACCTTCAACAAACTGTAAAATTAGCTGATCAAGCTTACGACTTCGTTCGTGATGCTGCAGCAAATGATGCTGTTATCTTGTTTGTTGGTACGAAAAAACAAGCTTCTGAAGCGATTAAAGAAGAGGCAGAACGTGCTGGTCAATACTATATCAACCACCGCTGGTTGGGTGGGACTTTGACAAACTGGGATACAATTCAAAAACGTATCGCACGTTTGAAAGAAATCAAACAAATGGAAGTTGATGGTATTTTTGATGTTCTTCCTAAAAAAGAAGTTGCTCTTCTTAATAAGCAACGTGCGCGTCTTGAAAAATTCTTGGGTGGTATCGAAGATATGCCTCGTATTCCAGATATTATCTACATCGTTGATCCGCACAAAGAACAAATTGCAGTTAAAGAAGCTAAGAAACTTGGTATTCCAGTTGTCGCTATGGTTGATACTAATGCTGATCCAGACGATATTGATGTTATTATCCCAGCAAATGACGATGCGATCCGCGCCGTTAAATTGATTACCAGCAAATTAGCTGATGCTGTGATTGAAGGTCGTCAAGGTGAAGACAGTGTTGAAGCTGTTGAAGCAGAACTTGCAGCTGGAGAAACACAAGCAGATTCAATTGAAGAAATTGTTGAAGTTGTTGAAGGCGCAAACGAAAATTAA","4.80","-10.77","29079","MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQTVKLADQAYDFVRDAAANDAVILFVGTKKQASEAIKEEAERAGQYYINHRWLGGTLTNWDTIQKRIARLKEIKQMEVDGIFDVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDIIYIVDPHKEQIAVKEAKKLGIPVVAMVDTNADPDDIDVIIPANDDAIRAVKLITSKLADAVIEGRQGEDSVEAVEAELAAGETQADSIEEIVEVVEGANEN","1901513","For other 'rs' genes see SMu1937 (rs4); SMu1836 (rs3); SMu1833 (rs17); SMu1829 (rs14); SMu1828 (rs8); SMu1825 (rs5) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). ","30S ribosomal protein S2","Cytoplasm","Numerous strong matches in gapped BLAST to 30S ribosomal protein S2; residues 1-259 are 81% similar to 30S ribosomal protein S2 of Streptococcus pyogenes (gi|13959506); residues 1-259 are 79% similar to 30S ribosomal protein S2 of Streptococcus pneumoniae (gi|15902019).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1832 (1e-115).","

InterPro
IPR001865
Family

Ribosomal protein S2
PR00395	$\"[6-24]T$ $\"[37-46]T$ $\"[87-104]T$ $\"[158-175]T$ $\"[175-186]T$ $\"[196-210]T$	RIBOSOMALS2
PF00318	$\"[9-225]T$	Ribosomal_S2
PS00962	$\"[6-17]T$	RIBOSOMAL_S2_1
SSF52313	$\"[6-242]T$	Ribosomal_S2

InterPro
IPR005706
Family

Ribosomal protein S2, bacterial and organelle form
PTHR12534	$\"[1-254]T$	Ribosom_S2_bac
TIGR01011	$\"[3-227]T$	rpsB_bact

","BeTs to 17 clades of COG0052COG name: Ribosomal protein S2Functional Class: JThe phylogenetic pattern of COG0052 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001865 (Ribosomal protein S2) with a combined E-value of 1.2e-68. IPB001865A 20-73 IPB001865B 91-104 IPB001865C 172-213","Residues 172-226 are 63% similar to a (RIBOSOMAL 30S CHLOROPLAST 40S P40 SA MITOCHONDRION) protein domain (PD280344) which is seen in RS2_STRPY.Residues 11-111 are 29% similar to a (RIBOSOMAL MITOCHONDRIAL S2 MITOCHONDRION) protein domain (PD106774) which is seen in RT02_PROWI.Residues 106-169 are 94% similar to a (RIBOSOMAL 30S CHLOROPLAST COMPLETE) protein domain (PD328397) which is seen in RS2_BACSU.Residues 56-104 are 87% similar to a (RIBOSOMAL 30S CHLOROPLAST COMPLETE) protein domain (PD000490) which is seen in RS2_STRPY.Residues 15-189 are 21% similar to a (RIBOSOMAL S2 MITOCHONDRION) protein domain (PD241081) which is seen in Q9XPI7_DICDI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 15 08:07:58 2002","Tue Jan 8 16:07:19 2002","Tue Oct 15 08:07:58 2002","Tue Jan 8 16:07:19 2002","Tue Jan 8 16:07:19 2002","Tue Jan 8 16:07:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1847 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 13:24:03 2002","Tue Jan 8 16:07:19 2002","pdb|1FJF|B Chain B, Structure Of The Thermus Thermophilus 30s R... 223 2e-059","SMU.2032c","","Residues 9 to 225 (E-value = 9.2e-102) place SMu1847 in the Ribosomal_S2 family which is described as Ribosomal protein S2 (PF00318)","Tue Jan 8 16:07:19 2002","","","","Higo,K., Otaka,E. and Osawa,S. Purification and characterization of 30S ribosomal proteins from Bacillus subtilis: correlation to Escherichia coli 30S proteins. Mol. Gen. Genet. 185 (2), 239-244 (1982) PubMed: 6806564.","","Tue Jan 8 16:07:19 2002","1","","","SMU.2032c","483" "SMu1848","1904324","1902471","1854","ATGATAAAAGATTTTCGGTTACGTTTTTTAGATAATTTAAAAAGCAATAAAGAAATTAAAAATTCAAGTAACGATTCCAATGACGATTCTTTAATGCTTAGCAGTTATTTATCATATAGTATTGTTTTTTTAATCTATGCCATAATAATAACTTATATATCATATATTTCTATAAACCGCGGTAGCTGGATGTATGATTATTCGTTTCATATGTCTAGAATAGTCGGCTTAGCTCAATCTCTAAAAAATGGAGACTGGCTCCCTAATTTAAATTATGTAATAGCTAATAACTCTGGCTATGCTGTAACCATGTTTTATGGGAATTGGCAGCTTTATATTCCGGCCCTTGTATTTTTAGCAACAAAAACGGCCACGTTTGCGTACTCAGTGTATGCTTTTCTGCTCATCTACAGTTCCTCTCTGACAGGTTTTTATTCCTTATATCAGATGAGTAAAAGTAGAAAGCGAGCTTTTATTTTTGCCTTGATACTGCCTATTACCATACCATTTTTTGGATATGGGATGGTGGCTGCTATTCCTTTGATACCATTATTATTTTATAGCCTGTATAAGGTCATATATAGTGAACGCTACAATCCTATGTTGCTAGCGGCAGTTATATCTTTGCTCATTCAAACACATGTGATATCAACAATAGTGCTAGGAATTGCTTCTGCTATATTTGTATTATTAAATAGTAACCAGCTAACACGACAAAAACTTTTTTCATTCTCCTTGTCTTTAGTTATAGGTCTTATTATGACTAGTGGCTATATTTTTCAATATGTAGAGCAAACTCAATCTCAAACTTTTTTTGTATCTTGGATAATAAGAGATTTTCCATTTCCAGCTAAGATTTTAATGCTTCCAAATAGTGTTGGAGATGCTATTATCAACTATCAATTTCCAATTGCCATAGTTATTATCGTTATAGGATTGGTATCTAGTTTTTGGATTAAAAGCGTTTCTCGAAAGCTTATTTTGATGTCACTCTTATTGCTTTTCTCAACCACAACATTAATTCCGTGGAAAATATTAAAGTATAGTTTTTTAGGTGTTTTTCAATATACAAATAGATTGGTGTATTTTCTTCCAATATACGTCTTGATGGCAGCGTGTATTTCTTTTAATAAATACCTTGTTATTTCAATCTGTATCTTTCAATTTGGTTATTATATAGTAACACAGCCTTATAAATATAGTTATGAAGAATATCGAGAAAGTATAGAATATTTAAAAAACACCAATACCTTTGCTGTAAAGGCATTTAAAAATCCGCTTCAGCTATCTTATGATACTAGTGGAGATGAATATCTCAACCTTTCTGTCAATCATGATGATATGCGAAATGGTTTAAGCCTCAATCAGTTTCTTTATAATCAGCAGGAGGTAGTTATTGAGAATGTTCGGCAAAAATATAATGATTTAGAATTTGATGTTTCGCTTAAAAGCAATCAACCTCAGACAATTGTTGTACCGAGAATTTGGTATAAGGGTTATAAAGCGTACTATAGCGACAAAGCTGTCGGAACACAGCCTAAAATAATCTATCAAAAATTATCGAAAGAAGAGCTAGCTCAATATTCTAAGGCCAAAAAACCTAAGGTGACAGAAAAAGCCTTATATAATGGTTTTGCTACGATTTCTGTATCACATTCAGGACATGTTCAAATAGCTTACAAAAAGACATTTGTACAGTGTATTGGATACACTATAGAAATTCTAGCTTGGCTTCCTAGGAAGGTTCGACAGCAATTATGGATGGTTTTATCTAAAATAGGAGAAACTATCATCCTATGTTCGAAGAAAATCAGACAGTATGTTGATGAAAATCTAAAGCGAAAAATAAGCTAA","10.30","27.02","71292","MIKDFRLRFLDNLKSNKEIKNSSNDSNDDSLMLSSYLSYSIVFLIYAIIITYISYISINRGSWMYDYSFHMSRIVGLAQSLKNGDWLPNLNYVIANNSGYAVTMFYGNWQLYIPALVFLATKTATFAYSVYAFLLIYSSSLTGFYSLYQMSKSRKRAFIFALILPITIPFFGYGMVAAIPLIPLLFYSLYKVIYSERYNPMLLAAVISLLIQTHVISTIVLGIASAIFVLLNSNQLTRQKLFSFSLSLVIGLIMTSGYIFQYVEQTQSQTFFVSWIIRDFPFPAKILMLPNSVGDAIINYQFPIAIVIIVIGLVSSFWIKSVSRKLILMSLLLLFSTTTLIPWKILKYSFLGVFQYTNRLVYFLPIYVLMAACISFNKYLVISICIFQFGYYIVTQPYKYSYEEYRESIEYLKNTNTFAVKAFKNPLQLSYDTSGDEYLNLSVNHDDMRNGLSLNQFLYNQQEVVIENVRQKYNDLEFDVSLKSNQPQTIVVPRIWYKGYKAYYSDKAVGTQPKIIYQKLSKEELAQYSKAKKPKVTEKALYNGFATISVSHSGHVQIAYKKTFVQCIGYTIEILAWLPRKVRQQLWMVLSKIGETIILCSKKIRQYVDENLKRKIS","1902489","","conserved hypothetical protein","Membrane, Cytoplasm","Residues 19-512 are 21% similar to residues 1-482 of gi|22993076, an hypothetical protein from Enterococcus faecium. Residues 33-554 are 18% similar to gi|1175775 YDNK_LACLC an hypothetical 70.0 kDa protein in dnaK 3'region (ORF4).SMu1848 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[202-347]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[36-56]?$ $\"[89-109]?$ $\"[128-148]?$ $\"[158-190]?$ $\"[209-231]?$ $\"[241-261]?$ $\"[297-317]?$ $\"[326-346]?$ $\"[360-380]?$	transmembrane_regions

InterPro
IPR003507
Family

Peptidase S66, LD-carboxypeptidase A
PF02016	$\"[10-307]T$	Peptidase_S66

","BeTs to 5 clades of COG1619COG name: Uncharacterized proteins, homologs of microcin C7 resistance protein MccFFunctional Class: SThe phylogenetic pattern of COG1619 is -------ceB-------l--xNumber of proteins in this genome belonging to this COG is 1","***** IPB003507 (Uncharacterized protein family UPF0094) with a combined E-value of 2.8e-45. IPB003507A 83-96 IPB003507B 103-131 IPB003507C 191-226 IPB003507D 281-301","Residues 2-81 are 55% similar to a (HYDROLASE PROTEOME YRGH COMPLETE) protein domain (PD038314) which is seen in Q9CEX1_LACLA.Residues 82-308 are 54% similar to a (HYDROLASE COMPLETE PROTEOME) protein domain (PD009804) which is seen in Q9CEX1_LACLA.Residues 30-302 are 23% similar to a (PROTEOME BH0726 COMPLETE) protein domain (PD320369) which is seen in Q9KEX3_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri Aug 18 17:07:42 2006","Fri Aug 18 17:07:42 2006","Fri Aug 18 17:07:42 2006","Tue Jan 8 15:57:02 2002","Tue Jan 8 15:57:02 2002","Tue Jan 8 15:57:02 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1849 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:32:34 2002","","No significant hits to the NCBI PDB database.","SMU.2035","","Residues 80 to 150 (E-value = 6.1e-34) place SMu1849 in the Peptidase_U61 family which is described as LD-carboxypeptidase (PF02016)","Tue Jan 8 15:57:02 2002","24380376","","","","","","1","","","SMU.2035","730" "SMu1850","1908114","1906219","1896","ATGGTACGTTTACAAGATGATTTTTATAACGCAGTCAATGGCCAGTGGGAAGAGGCAGCGGTCATTCCTGATGATAAACCACGGACGGGTGGCTTTTCTGACTTGGCTGATGATATTGAAGATTTAATGTTAGAAACTACTGACAAGTGGCTAGATGGGAAAGATGTTCCTGATGATAGTATTTTACAAAATTTTGTGAAGTTCCATCGTCAGGTGGCGGACTATGATGCGCGTGAAGAGACGGGTGTTAAGCCAGTGCTGCCTCTCATTGAAGAATATAAGAGTCTAACTTCTTTTGCTGATTTTGCTTCCAACATAGCCACTTATGAAATGGCTGGCAAGCCTAATGAGCTTCCTTTTGGTGTGGCACCGGATTTTATGAATGCACAAATGAATGTGCTTTGGGCAGAGGCTCCAAATCTTATTTTACCAGATACCACTTATTATGCTGAAGGTAATGACAAAGGTAAGGAACTGCTTGCTAAGTGGCGTACGATGCAAGAGGAACTTTTGCCTAAGTTTGGTTTTGAAGAAGCAGAAATTAAAGATCTTCTAGATAAGGTGCTTACTTTAGATGCCAAATTGGCTCAATATGTTCTTTCCAGTGAGGAATCATCAGAATATGTGAAGCTTTATCATCCTTATGATTGGGCTGATTTTACCAAATTAACACCAGAACTGCCTTTAGATGCGATTTTTACACAGATTTTAGGTCAAAAACCAGATAAAGTTATCGTTCCTGAAGAGCGTTTTTGGACAAATTTTGCAGCTGAATTTTATTCAGAAAAAAATTGGCCTTTCTTAAAAGCTACCTTAGTTTTAGCTGCAGCAAGTTCTTACAATTCTTACCTGACAGATGATATTCGTATCCTTTCAGGAAGCTATAATCGTGCTCTTTCAGGGACACCTCAAGCTATGGGTAAGAAAAAAGCCGCTTTTTATCTGGCTCAGGGCCCTTATAATCAAGCGCTCGGTCTTTGGTACGCTGGCGAGAAATTTTCTCCTGAGGCAAAGAAAGACGTGGAAGCTAAAGTGGCAACTATGATTGAGGTTTATAAAGAACGTTTGCATAAGACGGACTGGTTGGCTCAAGAAACGCGTAATAAGGCTATTACCAAACTCAATGTCATAACGCCTCATATTGGTTATCCAGAACAATTACCCAAGACTTATGCTCAAAAGATTATTGACGACAATCTCAGTCTAGTGGAAAATGCTCAAAATTTGGCTAAAATCTCAATTGCCTATAATTGGAGCAAGTGGAATCAACCAGTTGATCGCAGTGAATGGCATATGCCAGCTCACATGGTTAATGCTTACTATGATCCGCAGCAAAATCAAATTGTCTTTCCAGCGGCTATTTTGCAGGCACCATTTTATTCATTGGAGCAATCTTCATCTGCTAATTACGGTGGCATTGGTGCTGTCATTGCCCATGAAATCTCTCACGCTTTTGATACGAATGGCGCTTCCTTTGATGAAAATGGCAGTCTTAACAACTGGTGGACTGATGAAGATTATGCGGCTTTTAAAAAGCGTACAGACAGAGTTGTTGAACAGTTTGAAGGACTTGATTCTTATGGTGCTAAGGTCAACGGTCAGCTAACTGTTTCGGAAAATGTGGCTGATCTTGGTGGCCTTGCCTGTGCTCTTGAAGCTGCCAAACGTGAAGCAGATTTTTCTGTCCGTGATTTCTTTATTAATTTTGCAACGATCTGGCGCATGAAAGCACGCGACGAATATATGCAAATGCTAGCAAGTATTGACGTTCATGCTCCAGCTAAATGGCGGACCAATGTTACAATTACCAACTTTGACGAATTCCACCAAGAATTTGCGGTTAAAGAAGGTGATGGCATGTGGCGTGATGAAGATAAACGTGTTATTATTTGGTAG","4.60","-32.56","71759","MVRLQDDFYNAVNGQWEEAAVIPDDKPRTGGFSDLADDIEDLMLETTDKWLDGKDVPDDSILQNFVKFHRQVADYDAREETGVKPVLPLIEEYKSLTSFADFASNIATYEMAGKPNELPFGVAPDFMNAQMNVLWAEAPNLILPDTTYYAEGNDKGKELLAKWRTMQEELLPKFGFEEAEIKDLLDKVLTLDAKLAQYVLSSEESSEYVKLYHPYDWADFTKLTPELPLDAIFTQILGQKPDKVIVPEERFWTNFAAEFYSEKNWPFLKATLVLAAASSYNSYLTDDIRILSGSYNRALSGTPQAMGKKKAAFYLAQGPYNQALGLWYAGEKFSPEAKKDVEAKVATMIEVYKERLHKTDWLAQETRNKAITKLNVITPHIGYPEQLPKTYAQKIIDDNLSLVENAQNLAKISIAYNWSKWNQPVDRSEWHMPAHMVNAYYDPQQNQIVFPAAILQAPFYSLEQSSSANYGGIGAVIAHEISHAFDTNGASFDENGSLNNWWTDEDYAAFKKRTDRVVEQFEGLDSYGAKVNGQLTVSENVADLGGLACALEAAKREADFSVRDFFINFATIWRMKARDEYMQMLASIDVHAPAKWRTNVTITNFDEFHQEFAVKEGDGMWRDEDKRVIIW","1906237","For other 'pep' genes see SMu0587 (pepB); SMu0632 (pepT);SMu0649 (pepC); SMu1791 (pepA); SMu0358 (pepX),(pepXP); SMu0423 (pepC); SMu1034 (pepN); SMu1134 (pepV); SMu1190 (pepD); SMu1685 (pepP); SMu1415 (pepM) and SMu1447 (pepQ). From GenBank (gi:13432245): In Lactococcus lactis, this is an endopeptidase with braod substrate specificity for several oligopeptides. Optimum activity is measured at pH 6.0-6.5 and temperatures 30-38 degrees C. This monomer binds one zinc ion as a cofactor and belongs to peptidase family M13 (zinc metalloprotease), also known as the neprilysin subfamily.","endopeptidase O","Cytoplasm, Extracellular","Numerous strong matches in gapped BLAST to oligopeptidases/endopeptidases; residues 1-631 are 76% similar to endopeptidase O of Streptococcus pyogenes (gi|15675851); residues 1-631 are 64% similar to Endopeptidase O of Streptococcus pneumoniae (gi|15459150).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1890 (0.0).","

InterPro
IPR000718
Family

Peptidase M13, neprilysin
PR00786	$\"[430-442]T$ $\"[448-460]T$ $\"[469-485]T$ $\"[539-550]T$	NEPRILYSIN
PTHR11733	$\"[6-631]T$	Peptidase_M13
PF01431	$\"[438-628]T$	Peptidase_M13

InterPro
IPR006025
Binding_site

Peptidase M, neutral zinc metallopeptidases, zinc-binding site
PS00142	$\"[476-485]?$	ZINC_PROTEASE

InterPro
IPR008753
Domain

Peptidase M13
PF05649	$\"[3-384]T$	Peptidase_M13_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.390.10	$\"[314-631]T$	G3DSA:3.40.390.10
SSF55486	$\"[5-631]T$	SSF55486

","No hits to the COGs database.","***** PR00786 (Neprilysin metalloprotease (M13) family signature) with a combined E-value of 8.4e-37. PR00786A 430-442 PR00786B 448-460 PR00786C 469-485 PR00786D 539-550","Residues 578-631 are 70% similar to a (ENDOPEPTIDASE METALLOPROTEASE ZINC) protein domain (PD011850) which is seen in Q9XD02_STRPA.Residues 1-119 are 73% similar to a (OLIGOPEPTIDASE) protein domain (PD043072) which is seen in Q9F2E1_STRTR.Residues 335-547 are 22% similar to a (CHROMOSOME II F12A10.4) protein domain (PD400905) which is seen in Q09946_CAEEL.Residues 452-513 are 85% similar to a (METALLOPROTEASE ENDOPEPTIDASE ZINC) protein domain (PD415518) which is seen in Q9XD02_STRPA.Residues 472-573 are 35% similar to a (CG3775 CG9505) protein domain (PD289531) which is seen in Q9VYJ1_DROME.Residues 574-631 are 81% similar to a (OLIGOPEPTIDASE) protein domain (PD384196) which is seen in Q9F2E1_STRTR.Residues 5-220 are 67% similar to a (ZINC METALLOPROTEASE ENDOPEPTIDASE) protein domain (PD002031) which is seen in Q9XD02_STRPA.Residues 448-502 are 92% similar to a (ZINC ENDOPEPTIDASE HYDROLASE) protein domain (PD001606) which is seen in Q9F2E1_STRTR.Residues 508-573 are 86% similar to a (ZINC ENDOPEPTIDASE METALLOPROTEASE) protein domain (PD241703) which is seen in Q9F2E1_STRTR.Residues 415-485 are 36% similar to a (KELL BLOOD GLYCOPROTEIN GROUP) protein domain (PD415143) which is seen in Q9EQF2_MOUSE.Residues 315-489 are 22% similar to a (CG4723 CG4725) protein domain (PD290271) which is seen in Q9VCU3_DROME.Residues 258-462 are 24% similar to a (CG6265) protein domain (PD314169) which is seen in Q9VB85_DROME.Residues 517-573 are 45% similar to a (ENDOPEPTIDASE METALLOPROTEASE 3.4.24.-) protein domain (PD265847) which is seen in Q9L996_BBBBB.Residues 432-504 are 32% similar to a (CG15485) protein domain (PD396681) which is seen in Q9VK72_DROME.Residues 236-446 are 80% similar to a (ENDOPEPTIDASE METALLOPROTEASE ZINC HYDROLASE NEUTRAL) protein domain (PD358468) which is seen in Q9F2E1_STRTR.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Nov 26 14:23:20 2002","Tue Jan 8 15:50:26 2002","Tue Oct 15 07:59:10 2002","Tue Jan 8 15:50:26 2002","Tue Jan 8 15:50:26 2002","Tue Jan 8 15:50:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1850 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 11:09:20 2002","Tue Jan 8 15:50:26 2002","pdb|1DMT|A Chain A, Structure Of Human Neutral Endopeptidase Co... 221 2e-058","SMU.2036c","","Residues 3 to 384 (E-value = 6.2e-185) place SMu1850 in the Peptidase_M13_N family which is described as Peptidase family M13 (PF05649)Residues 438 to 628 (E-value = 5.3e-71) place SMu1850 in the Peptidase_M13 family which is described as Peptidase family M13 (PF01431)","Tue Jan 8 15:50:26 2002","","","","Tynkkynen,S., Buist,G., Kunji,E., Kok,J., Poolman,B., Venema,G. and Haandrikman,A. Genetic and biochemical characterization of the oligopeptide transport system of Lactococcus lactis. J. Bacteriol. 175 (23), 7523-7532 (1993) PubMed: 8244921.Chavagnat,F., Meyer,J. and Casey,M.G. Purification, characterisation, cloning and sequencing of the gene encoding oligopeptidase PepO from streptococcus thermophilus A. FEMS Microbiol. Lett. 191 (1), 79-85 (2000) PubMed: 11004403.","Tue Nov 26 14:23:20 2002","Tue Nov 26 14:23:20 2002","1","","","SMU.2036c","188" "SMu1851","1910251","1908623","1629","ATGACATTAGACAAAAGGAAAGTTGTCTATCAAATTTATCCCAAATCGTATAAAGACACAAGTGGAAATGGGGTCGGGGATCTTCAGGGAATTATTGAAAAATTACCTTATTTAGAAGAATTGGGAATTGATGTTATCTGGCTCAACCCATTTTATCCTAGTCCACAGCGCGATAACGGCTATGATGTGTCTGACTATACTGCTGTGAATCCTTTATTTGGGAGCATGGCCGATTTTGAAGAATTAGTACGCAAAGGAAAAGAGCATGGCATTGAGATCATGCTGGACATGGTACTCAATCACTGTTCGATAGAACACGAATGGTTCCAAAAGGCCTTGGCTGGAGATAAGTATTATCAGGATTTCTTTATTTTAAGAGATAGGCCTACTGACTGGGTTTCTAAATTCGGGGGCAATGCTTGGGCACCTTTTGGAGAGACAGGGAAGTATTACCTGCATCTGTATGATGTCACGCAGGCTGATTTAAATTGGCGCAATCCTCACGTTCGTGAGGAACTGTTTAAGGTGGTCAATTTCTGGCGCAACAGGGGAGTCAAGGGCTTTCGCTTTGATGTTATCAATGTGATTGGGAAAGACGAGGTCCTAAAGGATAATCCTCATTTTGATGGGAAACCTGAATATACAGACCGTCCCATTAATCATGATTATTTAAAAATGCTCAATAAAGCCAGCTTTGGTCAGGATGAAAATGGTATGACTGTTGGCGAGATGAGTTTTACAGACATTCCTAACTGCATACAATACAGCAATCCCGACAACCATGAATTGGATATGGTCTTTAATTTTCATCATCTTAAAGTGGATTATGAAAATGGTCAAAAATGGACACGCAAAACGTTTGATTTTGAAGAACTGAAACATCTCTTTCATACTTGGGGTGAAGGGATGAGTCAAGGTAACGGCTGGTCTGCTCTCTTTTGGAATAATCACGATCAGCCACGAGCGCTTAATCGCTTTGTTGATATTAAGCAGTTTCGCAATGAAGGAGCGACCATGCTTGCAGCCTCGATTCATTTATCTCGTGGTACGCCCTATATTTATATGGGGGAAGAAATTGGCATGATTGATCCAGACTATGGTTCTATGGCTGATTATGTTGATGTGGAAAGCCTGAATGCCTATCAAGAATTAATAGATAAAGGCAAATCTTCTGAGGAAGCCTTTCACATTATTCGAGCCAAATCGCGTGATAATGCACGTACCCCTATGCAATGGGATACTAGCGAGAATGCAGGTTTTTCAACTGGCAGGCCGTGGCTGAAGGTTGGAAAGAGCTACCCACAAATCAATGTGGCTAATGAAAAACAAGGTAAGATCTTTCCTTTTTATCAAAAATTGATTCGTTTGCGAAAAGAAATGCCGCTAATTGCTCAAGGCAGTTATCAAGCAGCTTTGACAGACAGTGATAAAATCTATGCCTTTGAACGAGAGTACGAAGGCCAAAAGCTGCTGGTTCTCAATAATTTCTTTGCTGAAACAGTTGAGCTAGACTTGCCTTCCCTTTATCAAGCAGGGACCGTTCTCATTAGTAATTACGATGATGTTATCTTAGATAAACGGATTTCCTTAAAACCTTATCAGACAGTAGCGATTTTAGCAGAAGTCTGA","5.30","-15.43","62761","MTLDKRKVVYQIYPKSYKDTSGNGVGDLQGIIEKLPYLEELGIDVIWLNPFYPSPQRDNGYDVSDYTAVNPLFGSMADFEELVRKGKEHGIEIMLDMVLNHCSIEHEWFQKALAGDKYYQDFFILRDRPTDWVSKFGGNAWAPFGETGKYYLHLYDVTQADLNWRNPHVREELFKVVNFWRNRGVKGFRFDVINVIGKDEVLKDNPHFDGKPEYTDRPINHDYLKMLNKASFGQDENGMTVGEMSFTDIPNCIQYSNPDNHELDMVFNFHHLKVDYENGQKWTRKTFDFEELKHLFHTWGEGMSQGNGWSALFWNNHDQPRALNRFVDIKQFRNEGATMLAASIHLSRGTPYIYMGEEIGMIDPDYGSMADYVDVESLNAYQELIDKGKSSEEAFHIIRAKSRDNARTPMQWDTSENAGFSTGRPWLKVGKSYPQINVANEKQGKIFPFYQKLIRLRKEMPLIAQGSYQAALTDSDKIYAFEREYEGQKLLVLNNFFAETVELDLPSLYQAGTVLISNYDDVILDKRISLKPYQTVAILAEV","1908641","For other 'dex' genes see SMu0806 (dexB) and SMu1854 (dexT).For other 'tre' genes see SMu1853 (treR) and SMu1852 (treB). From GenBank (gi:7404478): This protein is similar to TreC of B.subtilis, this protein catalyses the reaction: ALPHA,ALPHA-TREHALOSE 6-PHOSPHATE + H(2)O = D-GLUCOSE + D-GLUCOSE 6-PHOSPHATE. This cytoplasmic protein belongs to family 13 of glycosyl hydrolases, also known as the alpha-amylase family.","trehalose-6-phosphate hydrolase","Cytoplasm","Numerous strong matches in gapped BLAST to dextran glucosidases; residues 1-541 are 77% similar to dextran glucosidase of Streptococcus pyogenes (gi15675852); residues 1-538 are 75% similar to dextran glucosidase of Streptococcus pneumoniae (gi15903740). Also strongly similar to trehalose-6-phosphate hydrolases; residues 5-536 are 47% similar to trehalose-6-phosphate hydrolase of Bacillus subtilis (gi7404478).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0193 (0.0).","

InterPro
IPR006047
Domain

Glycosyl hydrolase, family 13, catalytic region
PF00128	$\"[11-407]T$	Alpha-amylase

InterPro
IPR006589
Domain

Glycosyl hydrolase, family 13, subfamily, catalytic region
SM00642	$\"[11-407]T$	Aamy

InterPro
IPR012769
Family

Alpha,alpha-phosphotrehalase
TIGR02403	$\"[3-540]T$	trehalose_treC

InterPro
IPR013780
Domain

Glycosyl hydrolase, family 13, all-beta
G3DSA:2.60.40.1180	$\"[467-541]T$	Glyco_hydro_13_b

InterPro
IPR013781
Domain

Glycoside hydrolase, catalytic core
G3DSA:3.20.20.80	$\"[5-466]T$	Glyco_hydro_cat

noIPR
unintegrated

unintegrated
PTHR10357	$\"[5-278]T$ $\"[310-539]T$	PTHR10357
PTHR10357:SF11	$\"[5-278]T$ $\"[310-539]T$	PTHR10357:SF11
SSF51011	$\"[466-541]T$	SSF51011
SSF51445	$\"[5-463]T$	SSF51445

","BeTs to 6 clades of COG0366COG name: GlycosidasesFunctional Class: GThe phylogenetic pattern of COG0366 is ----Y-VcEBR----------Number of proteins in this genome belonging to this COG is 4","No significant hits to the Blocks database.","Residues 308-506 are 27% similar to a (HYDROLASE GLUCOSIDASE MALTASE) protein domain (PD021736) which is seen in AGLA_RHIME.Residues 239-309 are 74% similar to a (HYDROLASE GLYCOSIDASE PROTEOME COMPLETE) protein domain (PD002863) which is seen in O07880_STRSU.Residues 10-111 are 28% similar to a (PROTEOME MALTODEXTRIN GLYCOSYLTRANSFERASE) protein domain (PD018483) which is seen in Q9KY04_STRCO.Residues 22-109 are 31% similar to a (ANTIGEN CHAIN HEAVY CD98) protein domain (PD187081) which is seen in 4F2_HUMAN.Residues 8-90 are 32% similar to a (C38C6.2) protein domain (PD273859) which is seen in O45298_CAEEL.Residues 58-91 are 79% similar to a (BRANCHING ENZYME TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD000114) which is seen in O07880_STRSU.Residues 95-198 are 88% similar to a (HYDROLASE ALPHA-AMYLASE GLYCOSIDASE PRECURSOR SIGNAL) protein domain (PD000173) which is seen in O07880_STRSU.Residues 310-349 are 82% similar to a (DEXTRAN GLUCOSIDASE DEXS) protein domain (PD083101) which is seen in O07880_STRSU.Residues 312-361 are 68% similar to a (HYDROLASE GLYCOSIDASE ALPHA-GLUCOSIDASE MALTASE PROTEOME) protein domain (PD201428) which is seen in Q9KTJ1_VIBCH.Residues 425-538 are 63% similar to a (HYDROLASE GLYCOSIDASE MALTASE PROTEOME COMPLETE) protein domain (PD002991) which is seen in O07880_STRSU.Residues 310-361 are 57% similar to a (HYDROLASE GLYCOSIDASE ALPHA-AMYLASE) protein domain (PD082291) which is seen in O16G_BACCE.Residues 31-122 are 35% similar to a (HYDROLASE SYNTHASE PROTEOME COMPLETE) protein domain (PD011989) which is seen in Q55262_SULSO.Residues 59-199 are 26% similar to a (F26D10.9) protein domain (PD237548) which is seen in Q9XVU3_CAEEL.Residues 5-56 are 92% similar to a (HYDROLASE GLYCOSIDASE PRECURSOR ALPHA-AMYLASE SIGNAL) protein domain (PD001430) which is seen in O07880_STRSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 22 12:13:09 2006","Tue Aug 22 12:13:09 2006","Tue Aug 22 12:13:09 2006","Tue Jan 8 15:22:29 2002","","Tue Jan 8 15:22:29 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1851 is paralogously related (blast p-value < 1e-3) to SMu0806,a predicted glucan 1,6-alpha-glucosidase; SMu1445, a predicted intracellular a-amylase and SMu1401,a predicted thermostable pullulanase.","Mon Apr 15 09:33:01 2002","Tue Aug 22 12:13:09 2006","pdb1UOK Crystal Structure Of B. Cereus Oligo-1,6-Glucosidase 451 7e-128pdb1BVZA Chain A, Alpha-Amylase Ii (Tvaii) From Thermoactinom... 127 3e-030pdb1SMAA Chain A, Crystal Structure Of A Maltogenic Amylase >... 102 8e-023","SMU.2037c","","Residues 11 to 407 (E-value = 9.7e-104) place SMu1851 in the Alpha-amylase family which is described as Alpha amylase, catalytic domain (PF00128)","Tue Jan 8 15:22:29 2002","","","Serhir,B., Dugourd,D., Jacques,M., Higgins,R. and Harel,J. Cloning and characterization of a dextranase gene (dexS) from Streptococcus suis. Gene 190 (2), 257-261 (1997) PubMed: 9197542.","Serhir,B., Dugourd,D., Jacques,M., Higgins,R. and Harel,J. Cloning and characterization of a dextranase gene (dexS) from Streptococcus suis. Gene 190 (2), 257-261 (1997) PubMed: 9197542.Gotsche,S. and Dahl,M.K. Purification and characterization of the phospho-alpha(1,1)glucosidase (TreA) of Bacillus subtilis 168. J. Bacteriol. 177 (10), 2721-2726 (1995) PubMed: 7751281.Helfert,C., Gotsche,S. and Dahl,M.K. Cleavage of trehalose-phosphate in Bacillus subtilis is catalysed by a phospho-alpha-(1-1)-glucosidase encoded by the treA gene. Mol. Microbiol. 16 (1), 111-120 (1995) PubMed: 7651129.","Mon Apr 8 11:31:36 2002","Thu Oct 24 16:07:23 2002","1","","","SMU.2037c","517" "SMu1852","1912244","1910277","1968","ATGGGAAAATTTGAAAAAGATGCCAAGGTATTACTAGATGCTATTGGCGGCAAAGAAAATGTTTCTGCTGTTACACATTGTGCAACACGTATGCGCTTTGTTTTAAATGATGAAAGTAAAGCCGATGTTAAGACAATTGAAGCTATTCCGGCTGTAAAGGGAACTTTTACCAATGCGGGGCAATTCCAAATTATTATTGGGAATGATGTTCCTTTGTTTTATAATGATTTTACAGCTGTTTCAGGTATTGAAGGGGTCTCTAAGGAAACCGCTAAGTCGGCTGCTAAAAGCCATCAGAATCCTATTCAGCGTGTGATGACTCTGTTAGCAGAAATTTTCACCCCTATTATCCCAGCTATCATTGTTGGGGGGCTGATTCTTGGATTTCGTAATGTCATTGATCAGGTTCAATGGGGATTTCTAGATGGACAAACAATCGCACAGCATTCACAATTTTGGAGTGGTATCAGTTCATTTCTATGGCTGCCGGGCGAAGCCATCTTCCAATTTTTACCTGTAGGTATTGTTTGGTCTGTCAGCCGTAAGATGGGAACGAGTCAAATTTTAGGTATTGTACTTGGAATTTGTTTGGTTTCACCGCAGCTGCTGAATGCCTATAATGTAGCTAGTACACCCGCAGCTGAAATCGCTAAAAAATGGGTTTGGGATTTTGGTTTCTTTACGGTGAGACGTATTGGTTATCAAGGGCAAGTTATCCCAGCTTTACTAGCTGGACTTTCTCTTTCGTATCTTGAGATCTTTTGGCGCAAGAAAATTCCAGAAGTGGTTTCCATGATTTTTGTTCCCTTTTTATCTCTTATCCCAGCATTGATTTTAGCCCATACTGTTCTGGGGCCAATTGGCTGGACTATTGGACAATGGATTTCAACAATTGTATATGCAGGTCTAACCGGTCCTGTTAAGTGGCTTTTTGGAGCTATCTTTGGAGCTCTTTATGCGCCATTTGTTATCACTGGTCTACATCATATGACTAATGCTATTGATACGCAATTAGTAGCAGATACAGGAGGTACAGGACTATGGCCAATGATTGCTCTTTCTAATATTGCTCAAGGATCAGCAGTATTTGCTTATTATCTTATGAACCGTCATGAAGAACGTGAAGCACAAGTTTCACTTCCAGCCACTATCTCAGCTTATCTTGGTGTGACAGAACCAGCACTTTTTGGGGTGAATATCAAATATGTTTATCCTCTTGTAGCTGGAATGATTGGCTCTTCCATTGCAGGCTTCCTTTCAGTCACATTTAACGTAACAGCTAATGCTATTGGTATTGGTGGTCTTCCAGGAATTTTGTCTATCAAAGTTAAATACATGCTTCCATTTTTCATCATTATGTTAGTTGCTATCGCAGTTCCTATGGTTTTAACAGTTTTCTTCCGTAGGATTAACTTTCTCACTAAATCTGAAGATGAAGCTCATCAAGAAAAAACAGAAACTGCTGAAATATCAGCATCAGAAAAGACTAATGAACCTGCTGTAGGAACAACGTTTGAGATTAAAAGTCCTTTAAAGGGTCAAGTCAAACCTTTGTCTGAAGCGGTTGATCCTGTTTTTGCCCAAGGTGTCATGGGACAAGGTGTTTTGATTGATCCAAGTGAAGGTCTCTTAACGTCTCCTGTTAATGGTGTGGTTTCTGTCCTCTTTCCAACAAAACATGCTCTTGGTCTTGTAACAGATCAAGGACTTGAATTATTGATCCATATTGGTATGGACACGGTCAATCTGGAAGGAAAAGGTTTTGAAACATATGTCAAACAAGGAGATACGATCAAGGTCGGAGACAAATTGATTCGTTTTGATATTGATGCTATCCATCAGGCAGGTTATACTACAGAGACACCTGTTATTGTCACCAATCAAAATGACTACCAGCCTGATGTCGTTGGAAGCCTTCCTCGTGAAATTGAACGCGGTGAGGTCCTCTTAACAGCAAGCAAAATATAG","6.20","-5.41","70835","MGKFEKDAKVLLDAIGGKENVSAVTHCATRMRFVLNDESKADVKTIEAIPAVKGTFTNAGQFQIIIGNDVPLFYNDFTAVSGIEGVSKETAKSAAKSHQNPIQRVMTLLAEIFTPIIPAIIVGGLILGFRNVIDQVQWGFLDGQTIAQHSQFWSGISSFLWLPGEAIFQFLPVGIVWSVSRKMGTSQILGIVLGICLVSPQLLNAYNVASTPAAEIAKKWVWDFGFFTVRRIGYQGQVIPALLAGLSLSYLEIFWRKKIPEVVSMIFVPFLSLIPALILAHTVLGPIGWTIGQWISTIVYAGLTGPVKWLFGAIFGALYAPFVITGLHHMTNAIDTQLVADTGGTGLWPMIALSNIAQGSAVFAYYLMNRHEEREAQVSLPATISAYLGVTEPALFGVNIKYVYPLVAGMIGSSIAGFLSVTFNVTANAIGIGGLPGILSIKVKYMLPFFIIMLVAIAVPMVLTVFFRRINFLTKSEDEAHQEKTETAEISASEKTNEPAVGTTFEIKSPLKGQVKPLSEAVDPVFAQGVMGQGVLIDPSEGLLTSPVNGVVSVLFPTKHALGLVTDQGLELLIHIGMDTVNLEGKGFETYVKQGDTIKVGDKLIRFDIDAIHQAGYTTETPVIVTNQNDYQPDVVGSLPREIERGEVLLTASKI","1910295","For other 'tre' genes see SMu1853 (treR) and SMu1851 (treC).From GenBank (gi:2851580): In Escherichia coli, EIIBC-tre is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system. It belongs to the EIIBC domain type and lacks a covalently bound EIIA domain. The IIB domain contains the phosphoryl transfer domain; the IIC domain contains the transmembrane channel. The EII-tre-mediated phosphorylation of trehalose requires the activity of enzyme IIA-glc, a component of the major glucose transport system. The reaction: protein N-phosphohistidine + sugar = protein hisitidine + sugar phosphate. This integral membrane complex contains a PTS EIIB domain and a PTS EIIC domain.","phosphotransferase system, trehalose-specific IIBC component (EIIBC-tre)","Membrane, Cytoplasm","Numerous strong matches in gapped BLAST to Phosphotransferase system, trehalose-specific IIBC component; residues 1-655 are 73% similar to EIIBC-tre of Streptococcus pneumoniae (gi|15903741); residues 5-466 are 47% similar to EIIBC-tre of Escherichia coli (gi|2851580).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0192 (0.0).","

InterPro
IPR001127
Domain

Phosphotransferase system, sugar-specific permease EIIA 1 domain
PD002243	$\"[504-629]T$	PTS_EIIA
PF00358	$\"[502-634]T$	PTS_EIIA_1
TIGR00830	$\"[507-627]T$	PTBA
PS00371	$\"[569-581]?$	PTS_EIIA_TYPE_1_HIS
PS51093	$\"[523-627]T$	PTS_EIIA_TYPE_1

InterPro
IPR001996
Domain

Phosphotransferase system, EIIB
PD001476	$\"[35-71]T$	Ptrans_EIIB
PF00367	$\"[8-42]T$	PTS_EIIB
PS01035	$\"[20-37]?$	PTS_EIIB_TYPE_1_CYS
PS51098	$\"[5-87]T$	PTS_EIIB_TYPE_1

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[110-413]T$	PTS_EIIC

InterPro
IPR011055
Domain

Duplicated hybrid motif
SSF51261	$\"[498-653]T$	Dup_hybrid_motif

InterPro
IPR011296
Domain

Phosphotransferase system, trehalose-specific IIBC component
TIGR01992	$\"[5-469]T$	PTS-IIBC-Tre

InterPro
IPR011535
Domain

Phosphotransferase system, glucose-like IIB component
TIGR00826	$\"[29-111]T$	EIIB_glc

InterPro
IPR013013
Domain

Phosphotransferase system, EIIC component, type 1
PS51103	$\"[107-483]T$	PTS_EIIC_TYPE_1

noIPR
unintegrated

unintegrated
G3DSA:2.70.70.10	$\"[493-654]T$	G3DSA:2.70.70.10
G3DSA:3.30.1360.60	$\"[2-94]T$	G3DSA:3.30.1360.60
SSF55604	$\"[7-85]T$	SSF55604

","No hits to the COGs database.","***** IPB001127 (Sugar-specific permease, EIIA 1 domain) with a combined E-value of 2.1e-41. IPB001127A 507-541 IPB001127B 546-588***** IPB001996 (PTS (phosphotransferase system) EIIB domain) with a combined E-value of 2.4e-24. IPB001996A 8-42 IPB001996B 58-70","Residues 314-400 are 28% similar to a (PROTEOME COMPLETE SYSTEM COMPONENT) protein domain (PD403132) which is seen in Q9CGG5_LACLA.Residues 46-296 are 49% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE II ENZYME IIBC) protein domain (PD003077) which is seen in Q9KTJ2_VIBCH.Residues 8-42 are 57% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIABC) protein domain (PD001476) which is seen in PTTB_BACSU.Residues 309-402 are 31% similar to a (BETA-GLUCOSIDE SPECIFIC TRANSPORT) protein domain (PD395003) which is seen in Q9X565_ENTFC.Residues 314-402 are 58% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE ENZYME II IIBC IIABC) protein domain (PD024747) which is seen in Q9KTJ2_VIBCH.Residues 523-627 are 58% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE TRANSPORT PTS IIABC) protein domain (PD002243) which is seen in Q9CFK9_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 18:38:02 2002","Thu Apr 11 09:14:40 2002","Thu Oct 10 18:38:02 2002","Tue Jan 8 15:05:31 2002","Tue Jan 8 15:05:31 2002","Tue Jan 8 15:05:31 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1852 is paralogously related (blast p-value < 1e-3) to SMu1677, a predicted PTS system, sucrose-specific IIABC component; SMu0890, a predicted beta-glucoside-specific EII permease and SMu1858, a predicted PTS system, enzyme II, A component.","Mon Apr 15 09:35:06 2002","Tue Jan 8 15:05:31 2002","pdb|1AX3| Solution Nmr Structure Of B. Subtilis Iiaglc, 16 S... 122 1e-028pdb|1GGR|A Chain A, Complex Of Enzyme Iiaglc And The Histidine-... 115 2e-026pdb|1F3G| Phosphocarrier Iiiglcfast >gi|2914331|pdb|1F3Z| ... 115 2e-026","SMU.2038c","","Residues 8 to 42 (E-value = 1e-16) place SMu1852 in the PTS_EIIB family which is described as phosphotransferase system, EIIB (PF00367)Residues 110 to 413 (E-value = 2.1e-37) place SMu1852 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)Residues 523 to 627 (E-value = 4.8e-54) place SMu1852 in the PTS_EIIA_1 family which is described as phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PF00358)","Tue Jan 8 15:05:31 2002","","","","Klein,W., Horlacher,R. and Boos,W. Molecular analysis of treB encoding the Escherichia coli enzyme II specific for trehalose. J. Bacteriol. 177 (14), 4043-4052 (1995) PubMed: 7608078.","Thu Apr 11 09:14:40 2002","Tue Jan 8 15:05:31 2002","1","","","SMU.2038c","" "SMu1853","1912418","1913131","714","ATGAAAAAATATGAAATTATTTTTAAAAAACTAGAAGAAGATATTCTCAAAGGACACTATCAAATGGGTGACTATCTTCCCCCTGAAATGGAACTTAGCCAGACCTATGCCAGCAGCCGAGATACTGTTAGAAAGGCTTTACAGCTCTTGACTAAGGCAGGTTTTATTAAAACAGTACAGGGAAGGGGATCCCAAATTATCAAGCGTGAGCGCATTAACTTTCCTGTTTCTCAACTAACCAGCTATCAAGAATTGGTTAAACAATTGCAGATGAATGTCAAGACAAATGTTATTGCTATTGATAAACTGATTGTTGATGAGAAACTCACCAAACTAACCGGTTTTGAAAATAAAGGTCTTGTCTGGCGCATCACAAGACAGCGCGTCATAGACGGCGTTGCTTCCATTTTAGATACGGATTATTTGGATAAAGCATTGATTCCTCATATGACCAGAGAAATCGCTGAACATTCTATCTATGATTATCTTGAAAATCAACTTAAGCTGGACATTGCCTATGCTCAAAAGATTATTACCATAGATCAAGTATCGCAAAAAGATAAAATTTTGCTTGATTTGGATTCTGAAAATCATGTCGTTTCGGTTAAATCTAAAGTTTATCTCAGTAATCAGCAGCAATTTCAATTCACTGAAAGCCGGCACAAACTGGAAAAGTTCCGTTTTGTTGACTTTGCCAGACGGCATCGTGATTAA","10.10","7.45","27766","MKKYEIIFKKLEEDILKGHYQMGDYLPPEMELSQTYASSRDTVRKALQLLTKAGFIKTVQGRGSQIIKRERINFPVSQLTSYQELVKQLQMNVKTNVIAIDKLIVDEKLTKLTGFENKGLVWRITRQRVIDGVASILDTDYLDKALIPHMTREIAEHSIYDYLENQLKLDIAYAQKIITIDQVSQKDKILLDLDSENHVVSVKSKVYLSNQQQFQFTESRHKLEKFRFVDFARRHRD","1913143","For other 'tre' genes see SMu1852 (treB) and SMu1851 (treC).From GenBank (gi:1717743): In B.subtilis, TreR is a respressor for the trehalose operon and belongs to the GntR family of transcriptional regulators.","trehalose operon transcriptional repressor (transcriptional regulator, GntR family)","Cytoplasm","Several strong matches in gapped BLAST to transcriptional regulators; residues 1-234 are 68% similar to transcriptional regulator, GntR family, of Streptococcus pyogenes (gi|15675854); residues 1-236 are 59% similar to trehalose operon transcriptional repressor of Streptococcus pneumoniae (gi|15901713).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0968 (6e-14).","

InterPro
IPR000524
Domain

Bacterial regulatory protein GntR, HTH
PR00035	$\"[26-40]T$ $\"[40-56]T$	HTHGNTR
PF00392	$\"[3-66]T$	GntR
SM00345	$\"[7-66]T$	HTH_GNTR
PS50949	$\"[1-69]T$	HTH_GNTR

InterPro
IPR011663
Domain

UbiC transcription regulator-associated
PF07702	$\"[88-227]T$	UTRA

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[4-69]T$	Wing_hlx_DNA_bd

InterPro
IPR012770
Family

Trehalose transcription repressor
TIGR02404	$\"[3-234]T$	trehalos_R_Bsub

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-73]T$	SSF46785

","No hits to the COGs database.","***** IPB000524 (Bacterial regulatory proteins, GntR family) with a combined E-value of 3.6e-12. IPB000524 26-66","Residues 7-64 are 43% similar to a (TRANSCRIPTIONAL REGULATOR DNA-BINDING) protein domain (PD000726) which is seen in Q9KEH9_BACHD.Residues 1-64 are 39% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD371622) which is seen in Q9RXP4_DEIRA.Residues 121-229 are 48% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD004095) which is seen in TRER_BACSU.Residues 4-85 are 47% similar to a (DNA-BINDING REGULATION TRANSCRIPTION) protein domain (PD410995) which is seen in Q9CID8_LACLA.Residues 94-236 are 47% similar to a (PROTEOME TRANSCRIPTIONAL COMPLETE) protein domain (PD398425) which is seen in Q9CID8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 18:35:25 2002","Tue Jan 8 14:46:19 2002","Thu Oct 10 18:35:25 2002","Tue Jan 8 14:46:19 2002","Tue Jan 8 14:46:19 2002","Tue Jan 8 14:46:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1853 is paralogously related (blast p-value < 1e-3) to SMu0973,a predicted transcriptional regulator, GntR family; SMu0865,a predicted conserved hypothetical protein; possible transcriptional regulator, and SMu0582,a predicted transcriptional regulator.","Mon Apr 15 09:36:51 2002","","No significant hits to the NCBI PDB database.","SMU.2040","","Residues 3 to 66 (E-value = 5e-16) place SMu1853 in the GntR family which is described as Bacterial regulatory proteins, gntR family (PF00392)","Tue Jan 8 14:46:19 2002","24380380","","","Helfert,C., Gotsche,S. and Dahl,M.K. Cleavage of trehalose-phosphate in Bacillus subtilis is catalysed by a phospho-alpha-(1-1)-glucosidase encoded by the treA gene. Mol. Microbiol. 16 (1), 111-120 (1995) PubMed: 7651129.","","Tue Jan 8 14:52:15 2002","1","","","SMU.2040","" "SMu1854","1916029","1913477","2553","ATGGAACAGTCAAATAGGCAAACGGCTGAACCAGCTATTAGGTCAGCTGAAACGGTGGATTCGACCATTAACTCTTTTCAAGAGACAGACCTTAAGGTGCAAGAGAAGGAGGATGTTGCGGCTGCAGTACAGACAGAATCAGCGTCAATAGATTCTAATGAACAGGGACAATCGGTCTCTGCAAATACTAACACACAATCTCAAGCGAAGAAACTTTCTAACAATTCCCATCAGGAGCCAATGCAAATGGTATCTGCCGCCAATAAAGAAAGGGCAGTGCTAGAAACTGCACAGAACCAAAAGAATGGCAACATGATAAATCTGACAACAGATAAAGCAGTCTATCAGGCGGGAGAGGCTGTTCATTTGAACCTTACTTTAAACAATACAACATCTTTAGCCCAAAATATTACAGCTACTGCTGAGGTTTATTCTCTTGAAAATAAATTAAAGACACTTCAGTATACGAAGTATCTTCTGCCTAATGAAAGTTATACAACTCAAAAAGGTGAATTCGTTATTCCTGCAAACTCCTTAGCTAATAATCGCGGTTATCTTTTGAAGGTTAACATATCAGATAGCCAAAATAATATTTTAGAGCAGGGCAATCGGGCTATTGCGGTTGAGGATGACTGGCGTACCTTTCCGCGTTATGCTGCTATTGGAGGTTCTCAAAAAGACAATAACAGTGTCTTGACTAAGAACTTACCAGATTATTATCGCGAATTAGAGCAGATGAAAAATATGAACATTAATTCCTATTTCTTCTATGATGTTTATAAGTCTGCTACAAATCCTTTCCCTAATGTTCCTAAGTTTGATCAGTCTTGGAATTGGTGGAGCCATTCGCAGGTTGAAACAGATGCTGTTAAAGCCTTGGTCAATCGTGTCCATCAAACTGGCGCTGTTGCCATGCTCTATAATATGATTTTAGCACAGAATGCTAATGAAACGGCTGTTTTACCAGATACTGAGTACATCTATAATTATGAGACTGGTGGTTATGGTCAAAATGGTCAGGTCATGACTTACTCTATTGATGATAAGCCGCTGCAATATTATTACAATCCTTTGAGTAAAAGTTGGCAAAATTATATTTCTAATGCCATGGCTCAAGCTATGAAAAATGGCGGTTTTGATGGCTGGCAGGGAGATACAATTGGAGATAATCGTGTTCTTTCCCATAATCAAAAGGACAGTCGAGATATTGCTCATTCCTTTATGTTATCTGATGTCTATGCTGAATTTCTCAATAAAATGAAGGAAAAACTGCCTCAGTATTATTTAACACTCAATGATGTTAATGGTGAAAATATCAGCAAACTCGCCAACAGCAAACAAGATGTGATTTACAATGAATTATGGCCTTTTGGAACTTCAGCTTTGGGGAACCGTCCCCAAGAAAGTTATGGTGACTTGAAAGCTCGTGTTGATCAAGTTCGCCAAGCGACAGGGAAATCTTTGATTGTCGGAGCTTATATGGAAGAGCCTAAATTTGATGATAATAGGGTTCCTCTCAATGGTGCAGCGCGTGACGTTTTAGCTTCAGCAACTTACCAAACAGATGCGGTTCTGCTGACAACTGCGGCCATTGCGGCAGCAGGAGGATATCACATGTCTCTGGCTGCTCTGGCTAATCCTAATGATGGGGGTGGTGTCGGTGTCTTAGAAACAGCTTATTATCCAACACAAAGCCTCAAGGTTTCGAAAGAGCTCAATCGTAAAAACTATCATTACCAACAATTTATTACGGCTTATGAAAATCTTTTGCGTGATAAAGTTGAAAATGATTCTGCTGAACCTCAGACTTTCACTGCTAACGGTCGGCAGCTATCGCAAGATGCTTTGGGGATCAATGGCGATCAGGTTTGGACTTATGCCAAAAAGGGAAACGATTTCAGAACGATTCAATTGCTCAACCTTATGGGAATTACATCCGACTGGAAAAATGAAGATGGTTATGAAAATAATAAAACACCTGATGAGCAAACCAATTTATTGGTTACTTATCCTTTGACTGGTGTGTCTATGGCAGAGGCTGATCGAATAGCTAAACAAGTCTATCTGACGTCACCAGATGATTGGCTGCAATCTAGTATGATTTCTCTAGCGACCCAGATAAAAACGAATGAGAATGGCGATCCTGTTCTTTATATTCAAGTGCCAAGACTGACGCTTTGGGATATGATTTATATTAATGAAACCATTAAACCAGAAACGCCTAAAGTTCCAGAACAGCCCCAACATCCTGCTAGGACACTTGAACCAGCAATTCCGCAAACTCCAGAAGCAGTCAGCCCTCTCCCAGTAGCTAATAAGCAGGCAGTAGATGAAAATAAAAATGAGATTGTTTCAGCCTTAACCGGTGAAGAAAATGACTTGCAGTTGCCAACTCTTTCCAAACGATCATTGTCAATCTCCCAAGCAGAGTTACCGCAAACAGGAGATAACAATGAAACGCGCTCCAATCTCCTCAAAGTGATAGGTGCTGGTGCGCTTCTAATCGGCGCTGCAGGATTATTAAGCTTGATAAAGGGTAGAAAAAAAGATTGA","4.80","-22.75","94478","MEQSNRQTAEPAIRSAETVDSTINSFQETDLKVQEKEDVAAAVQTESASIDSNEQGQSVSANTNTQSQAKKLSNNSHQEPMQMVSAANKERAVLETAQNQKNGNMINLTTDKAVYQAGEAVHLNLTLNNTTSLAQNITATAEVYSLENKLKTLQYTKYLLPNESYTTQKGEFVIPANSLANNRGYLLKVNISDSQNNILEQGNRAIAVEDDWRTFPRYAAIGGSQKDNNSVLTKNLPDYYRELEQMKNMNINSYFFYDVYKSATNPFPNVPKFDQSWNWWSHSQVETDAVKALVNRVHQTGAVAMLYNMILAQNANETAVLPDTEYIYNYETGGYGQNGQVMTYSIDDKPLQYYYNPLSKSWQNYISNAMAQAMKNGGFDGWQGDTIGDNRVLSHNQKDSRDIAHSFMLSDVYAEFLNKMKEKLPQYYLTLNDVNGENISKLANSKQDVIYNELWPFGTSALGNRPQESYGDLKARVDQVRQATGKSLIVGAYMEEPKFDDNRVPLNGAARDVLASATYQTDAVLLTTAAIAAAGGYHMSLAALANPNDGGGVGVLETAYYPTQSLKVSKELNRKNYHYQQFITAYENLLRDKVENDSAEPQTFTANGRQLSQDALGINGDQVWTYAKKGNDFRTIQLLNLMGITSDWKNEDGYENNKTPDEQTNLLVTYPLTGVSMAEADRIAKQVYLTSPDDWLQSSMISLATQIKTNENGDPVLYIQVPRLTLWDMIYINETIKPETPKVPEQPQHPARTLEPAIPQTPEAVSPLPVANKQAVDENKNEIVSALTGEENDLQLPTLSKRSLSISQAELPQTGDNNETRSNLLKVIGAGALLIGAAGLLSLIKGRKKD","1913495","For other 'dex' genes see SMu0806 (dexB) and SMu1851 (dexS).From GenBank (gi:2498300): This S.mutans protein may play a role in sucrose-independent adherence to the pellicle-coated tooth surface. Its catalytic activity is the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran. This homodimer is a type I membrane protein of the cell wall. It also shows similarity to other streptococcal and staphylococcal proteins in the region of the membrane anchor. It belongs to family 66 of glycosyl hydrolases.","dextranase ( 1,6-alpha-glucanhydrolase )","Extracellular, Cellwall","This protein is nearly identical to a previously sequenced S. mutans protein, dextranase (gi2498300), submitted to GenBank.Several strong matches in gapped BLAST to dextranases; residues 2-814 are 45% similar to dextranase of Streptococcus sobrinus (gi729317); residues 179-747 are 52% similar to dextranase of Streptococcus salivarius (gi3023639).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0477 (9e-04).","

InterPro
IPR001899
Domain

Surface protein from Gram-positive cocci, anchor region
TIGR01167	$\"[810-848]T$	LPXTG_anchor
PS50847	$\"[811-850]T$	GRAM_POS_ANCHORING

InterPro
IPR014756
Domain

Immunoglobulin E-set
SSF81296	$\"[106-132]T$	Ig_E-set

noIPR
unintegrated

unintegrated
SSF51445	$\"[204-429]T$	SSF51445

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 518-735 are 93% similar to a (PRECURSOR SIGNAL DEXTRANASE) protein domain (PD013540) which is seen in DEXT_STRMU.Residues 736-823 are 96% similar to a (DEXTRANASE ALPHA-16-GLUCAN-6- PRECURSOR) protein domain (PD108727) which is seen in DEXT_STRMU.Residues 1-178 are 84% similar to a (DEXTRANASE ALPHA-16-GLUCAN-6- PRECURSOR) protein domain (PD138086) which is seen in DEXT_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 1 14:04:07 2007","Thu Mar 1 14:04:07 2007","Thu Mar 1 14:04:07 2007","Tue Jan 8 14:39:16 2002","","Tue Jan 8 14:39:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1854 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Apr 8 11:30:41 2002","","No significant hits to the NCBI PDB database.","SMU.2042c","","No significant hits to the Pfam 11.0 database","Tue Jan 8 14:39:16 2002","","","Morisaki H, Igarashi T, Yamamoto A, Goto N. Analysis of a dextran-binding domain of the dextranase of Streptococcus mutans.Lett Appl Microbiol. 2002;35(3):223-7.PMID: 12180945Igarashi T, Morisaki H, Yamamoto A, Goto N. An essential amino acid residue for catalytic activity of the dextranase of Streptococcus mutans.Oral Microbiol Immunol. 2002 Jun;17(3):193-6.PMID: 12030973Igarashi,T., Yamamoto,A. and Goto,N. Sequence analysis of the Streptococcus mutans Ingbritt dexA gene encoding extracellular dextranase. Microbiol. Immunol. 39 (11), 853-860 (1995) PubMed: 8657012.Colby,S.M., Whiting,G.C., Tao,L. and Russell,R.R. Insertional inactivation of the Streptococcus mutans dexA (dextranase) gene results in altered adherence and dextran catabolism. Microbiology 141 (Pt 11), 2929-2936 (1995) PubMed: 8535521.","Igarashi T, Yamamoto A, Goto N. Nucleotide sequence and molecular characterization of a dextranase gene from Streptococcus downei.Microbiol Immunol. 2001;45(5):341-8.PMID: 11471821Igarashi T, Ichikawa K, Yamamoto A, Goto N. Identification of mutans streptococcal species by the PCR products of the dex genes.J Microbiol Methods. 2001 Aug;46(2):99-105.PMID: 11412920 ","Sat Oct 26 17:21:05 2002","Sat Oct 26 17:22:18 2002","1","","","SMU.2042c","" "SMu1855","1916960","1916514","447","ATGAAAATTGTCATTCAGCGCGTTATGAAAGCCAGTCTGACTGTTAATGGTAAGAGCAGGGCTTCCATTAACCAAGGCCTAGTCTTATTAGTCGGGATAGGTCCAGATGATGTTCAAGAAGACCTAACTTATGCTGTTCGGAAAATTACTAATATGAGAATTTTTTCGGATGAAGAAGGAAAGATGAACCTTTCCGTTCGAGACATTAAGGGGGAGGTTCTTTCTGTGTCTCAATTTACTCTTTTTGCTAATACGAAAAAGGGCAACCGTCCGGCCTTCACAGGAGCAGCGCAAGCGGATTTAGCCAGTTATTTGTATGATCAATTTAACCAAGAGCTAGCTCAGTTTGTTCCTGTTCAAACAGGAATATTTGGCTCTGATATGCAGGTATCTCTTACTAATGATGGCCCTGTGACGATTCTATTGGATACAAAAAATAAAGAGTAG","6.90","-0.01","16230","MKIVIQRVMKASLTVNGKSRASINQGLVLLVGIGPDDVQEDLTYAVRKITNMRIFSDEEGKMNLSVRDIKGEVLSVSQFTLFANTKKGNRPAFTGAAQADLASYLYDQFNQELAQFVPVQTGIFGSDMQVSLTNDGPVTILLDTKNKE","1916532","","D-tyrosyl-tRNA deacylase","Periplasm, Membrane, Cytoplasm","Many strong matches in gapped BLAST to conserved hypothetical proteins; residues 1-145 are 72% similar to conserved hypothetical protein of Streptococcus pyogenes (gi15675771).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1939 (6e-55).","

InterPro
IPR003732
Family

D-tyrosyl-tRNA(Tyr) deacylase
PD005653	$\"[17-139]T$	DTyrtRNA_deacyls
G3DSA:3.50.80.10	$\"[1-144]T$	DTyrtRNA_deacyls
PTHR10472	$\"[1-145]T$	DTyrtRNA_deacyls
PF02580	$\"[2-144]T$	Tyr_Deacylase
TIGR00256	$\"[1-145]T$	DTyrtRNA_deacyls
SSF69500	$\"[1-144]T$	DTyrtRNA_deacyls

noIPR
unintegrated

unintegrated
PTHR10472:SF4	$\"[1-145]T$	PTHR10472:SF4

","BeTs to 6 clades of COG1490COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1490 is ----yqv-ebrh---------Number of proteins in this genome belonging to this COG is 1","***** IPB003732 (DUF154) with a combined E-value of 5.7e-69. IPB003732A 1-29 IPB003732B 35-66 IPB003732C 70-115 IPB003732D 122-141","Residues 28-145 are 74% similar to a (COMPLETE PROTEOME 0610006H08RIK ORF1) protein domain (PD005653) which is seen in Q54088_STREQ.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 17 18:02:01 2006","Mon Jul 17 18:02:01 2006","Mon Jul 17 18:02:01 2006","Tue Jan 8 14:22:45 2002","Tue Jan 8 14:22:45 2002","Tue Jan 8 14:22:45 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1855 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:31:22 2002","","No significant hits to the NCBI PDB database.","SMU.2043c","","Residues 28 to 144 (E-value = 2.9e-73) place SMu1855 in the Tyr_Deacylase family which is described as D-Tyr-tRNA(Tyr) deacylase (PF02580)","Tue Jan 8 14:22:45 2002","24380382","","","","","","1","","","SMU.2043c","863" "SMu1856","1919189","1916967","2223","ATGGCGAAAGATGCAAATTTAACAGGTCAAGAGGTTATTGATATCTGCTCAATGTATATGAATAAAGCAGATATTGCCTTTGTTCAAAAAGCTTTAGATTATGCCACGGAATGCCATAGCGGTCAATTTCGTAAGTCAGGGGAACCTTATATTATTCATCCTATTCAGGTTGCAGGAATTTTAGCCGACTTACATTTGGATGCTATTACAGTTTCCTGTGGCTTTTTGCATGATGTCATTGAAGATACCGAAGCAACTTTAGATCATTTAGAAGCTAAATTTGGCAGTGATGTTAAGAACATTGTTGATGGTGTCACAAAGCTAGGGAAAGTTGAGTATAAATCGCATGAAGAACAGCTAGCAGAAAATCACCGTAAGATGTTGATGGCTATGTCTAAAGATATTCGTGTCATTCTGGTTAAATTAGCTGACCGTCTTCATAATATGCGGACGCTGAGGCATTTACGCAAGGATAAGCAAGAACGTATTTCACGCGAAACCATGGAAATTTATGCTCCCTTGGCGCATCGGCTGGGGATTAGTCGCATCAAATGGGAATTAGAAGATTTAGCTTTTCGTTATCTTAATGAAGTTGAATTTTATAAAATTTCGCATTTAATGAACGAAAAGCGTCGTGAACGTGAAGCATTAGTTGATGATATTGTTGATAAAATTAAAGCTTATACTGCAGAGCAGGGCTTACATGGTGAGATTTACGGACGTCCCAAACACATTTATTCCATTTATCGGAAGATGCGTGATAAGAAGAAACGTTTTGATCAAATTTATGATTTGATCGCTATTCGTTGTATTTTGGATACACAAAGTGATGTTTATGCCATGCTGGGTTATATTCATGAGCTTTGGCGTCCTATGCCCGGTCGTTTTAAGGACTATATTGCTAACCCTAAAGCAAATGGTTACCAATCCATTCATACAACTGTTTATGGACCCAAAGGGCCAATTGAAGTACAAATTCGGACGCATGAAATGCATCAAGTGGCTGAATATGGGGTAGCAGCTCACTGGGCTTATAAAAAGGGAATCAAAGGTAAGGTTAACAGTCAAGAATCAGCTCTAGGAATGAACTGGATTAAGGAACTTGTTGAGTTGCAAGACGCTTCCAATGGCAATGCGGTTGACTTTGTTGATTCTGTCAAAGAAGATATCTTTGCAGAGCGTATTTATGTTTTCACACCTAATGGTGCTGTTCAAGAATTGCCTAAGGATTCTGGTCCTATTGACTTTGCCTATGCCATTCATACACAGGTTGGAGAAAAAGCAACAGGCGCTAAAGTTAATGGTCGCATGGTCCCTTTAACAGCTAAGCTCAAAACAGGTGATGTGGTTGAAATCATCACAAATTCCAATTCTTTTGGTCCCAGCCGTGACTGGATTAATATTGTTAAGACCAATAAAGCTCGTAATAAAATTCGTCAATTTTTTAAAAACCAAGATAAGGAACTCTCTATCACAAAAGGCCGTGATTTGCTGGTTGATTATTTTCAAGAGCAGGGCTATGTGGCCAATAAATATTTGGATAGAAAACATATAGAGGCTGTTTTGAATCGTCTCAACTACCGTAATGAAGGAGCTCTTTATGCGGCTGTCGGTTTTGGTGAATTGTCGCCTGTTACCGTCTTTAATAAATTGACAGAAAAAGAACGCCGTGAACAAGAACGTGCCAAAGCTAAAGCGGAGGCTGAGGAACTCATGAAGGGCGGTGAAGTCAAGCACGACAATAAAAAAGAAGTCCTTAAGGTTAAAAGTGAAGGCGGTGTTATTGTTCAAGGCTCCTCTGGTCTTTTGATGCGGATTGCTAAGTGCTGTAACCCTGTCCCAGGCGATCCTATTGAAGGCTATATCACAAAAGGGCGTGGCGTCGCTATTCATCGTGCTGACTGTCATAATATTAAGAGTCAAGAAGGCTATGAAGAGCGTTTGATTGATGTCGAATGGGAAGATGATTATTCCACCAAGGAATATATGGCAGAAATTGATATTTATGGTCTCAACCGTGCCGGTCTCTTAAATGATGTTCTGCAAATCTTATCGAATCAAACAAAGAACATCTCAACGGTCAACGCCCAGCCAACTAAGGATATGAAATTTGCCAATATCCATGTGACTTTTGGCATCCCTAACTTAACCGTTTTAACAGCTGTTGTTGATAAAATTAAGGTCATTCCAGATGTTTATTCTGTTAAAAGGACTAACGGGTAA","8.20","8.53","84088","MAKDANLTGQEVIDICSMYMNKADIAFVQKALDYATECHSGQFRKSGEPYIIHPIQVAGILADLHLDAITVSCGFLHDVIEDTEATLDHLEAKFGSDVKNIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLRHLRKDKQERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNEVEFYKISHLMNEKRREREALVDDIVDKIKAYTAEQGLHGEIYGRPKHIYSIYRKMRDKKKRFDQIYDLIAIRCILDTQSDVYAMLGYIHELWRPMPGRFKDYIANPKANGYQSIHTTVYGPKGPIEVQIRTHEMHQVAEYGVAAHWAYKKGIKGKVNSQESALGMNWIKELVELQDASNGNAVDFVDSVKEDIFAERIYVFTPNGAVQELPKDSGPIDFAYAIHTQVGEKATGAKVNGRMVPLTAKLKTGDVVEIITNSNSFGPSRDWINIVKTNKARNKIRQFFKNQDKELSITKGRDLLVDYFQEQGYVANKYLDRKHIEAVLNRLNYRNEGALYAAVGFGELSPVTVFNKLTEKERREQERAKAKAEAEELMKGGEVKHDNKKEVLKVKSEGGVIVQGSSGLLMRIAKCCNPVPGDPIEGYITKGRGVAIHRADCHNIKSQEGYEERLIDVEWEDDYSTKEYMAEIDIYGLNRAGLLNDVLQILSNQTKNISTVNAQPTKDMKFANIHVTFGIPNLTVLTAVVDKIKVIPDVYSVKRTNG","1916985","From GenBank (gi:2498843): In eubacteria, PPGPP (guanosine 3'-diphosphate 5-'diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyses the formation of PPPGPP which is then hydrolysed to form PPGPP. The reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5-'triphosphate, is the first step in the metabolism of PPGPP. This protein belongs to the RelA/SpoT family.","GTP pyrophosphokinase","Cytoplasm","Numerous strong matches in gapped BLAST to GTP pyrophosphokinase; residues 1-740 are 75% similar to GTP pyrophosphokinase of Streptococcus pneumoniae (gi15901481); residues 1-740 are 82% similar to stringent response-like protein of Streptococcus equisimilis (gi2498843).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1940 (0.0).","

InterPro
IPR002912
Domain

Amino acid-binding ACT
PF01842	$\"[664-731]T$	ACT

InterPro
IPR003607
Domain

Metal-dependent phosphohydrolase, HD region
SM00471	$\"[46-158]T$	HDc

InterPro
IPR004095
Domain

TGS
PF02824	$\"[395-454]T$	TGS

InterPro
IPR004811
Family

RelA/SpoT protein
TIGR00691	$\"[31-737]T$	spoT_relA

InterPro
IPR006674
Domain

Metal-dependent phosphohydrolase, HD region, subdomain
PF01966	$\"[50-149]T$	HD

InterPro
IPR007685
Domain

RelA/SpoT
PF04607	$\"[240-349]T$	RelA_SpoT

InterPro
IPR012675
Domain

Beta-grasp fold, ferredoxin-type
G3DSA:3.10.20.30	$\"[394-457]T$	Ferredoxin_fold

InterPro
IPR012676
Domain

TGS-like
SSF81271	$\"[395-455]T$	TGS-like

noIPR
unintegrated

unintegrated
PTHR21262	$\"[121-740]T$	PTHR21262
SSF109604	$\"[5-196]T$	SSF109604
SSF55021	$\"[658-738]T$	SSF55021
SSF81301	$\"[197-371]T$	SSF81301

","BeTs to 9 clades of COG0317COG name: Guanosine polyphosphate pyrophosphohydrolases/synthetasesFunctional Class: T,KThe phylogenetic pattern of COG0317 is -----qvcEbrHujgpo----Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 195-349 are 89% similar to a (SYNTHETASE PROTEOME COMPLETE KINASE) protein domain (PD002902) which is seen in RELA_STREQ.Residues 35-148 are 64% similar to a (SYNTHETASE COMPLETE PROTEOME) protein domain (PD002764) which is seen in RELA_STAAU.Residues 322-380 are 45% similar to a (MANGANESE 3'-PYROPHOSPHOHYDROLASE) protein domain (PD213177) which is seen in SPOT_AQUAE.Residues 313-388 are 33% similar to a (PROTEOME 3'-PYROPHOSPHOHYDROLASE COMPLETE) protein domain (PD272244) which is seen in Q9PN26_CAMJE.Residues 149-192 are 72% similar to a (3'-PYROPHOSPHOHYDROLASE PROTEOME SYNTHETASE COMPLETE) protein domain (PD371068) which is seen in RELA_STRCO.Residues 108-148 are 58% similar to a (PROTEOME PPPGPP TRANSFERASE COMPLETE) protein domain (PD405475) which is seen in Q9RH69_BRAJA.Residues 149-194 are 73% similar to a (SYNTHETASE GTP KINASE PYROPHOSPHOKINASE) protein domain (PD334556) which is seen in RELA_STAAU.Residues 601-737 are 25% similar to a (HYDROLASE KINASE/PHOSPHOHYDROLASE) protein domain (PD118638) which is seen in O69970_STRCO.Residues 350-392 are 81% similar to a (SYNTHETASE ATP:GTP PPPGPP RESPONSE-LIKE) protein domain (PD375265) which is seen in RELA_STREQ.Residues 613-697 are 30% similar to a (PPPGPP TRANSFERASE SYNTHETASE HOMOLOG) protein domain (PD414392) which is seen in Q9RH69_BRAJA.Residues 393-737 are 78% similar to a (SYNTHETASE COMPLETE PROTEOME KINASE) protein domain (PD003989) which is seen in RELA_STREQ.Residues 184-218 are 77% similar to a (PYROPHOSPHOKINASE PROTEOME COMPLETE GTP SYNTHETASE PPGPP) protein domain (PD253748) which is seen in Q9CJ94_LACLA.Residues 149-183 are 97% similar to a (HYDROLASE COMPLETE) protein domain (PD368508) which is seen in RELA_STREQ.Residues 108-148 are identical to a (SYNTHETASE PPGPP PROTEOME GTP) protein domain (PD378346) which is seen in Q9CJ94_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 10:26:31 2006","Thu Aug 24 10:03:26 2006","Thu Aug 24 10:03:26 2006","Tue Jan 8 14:14:55 2002","","Thu Aug 24 10:26:31 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1856 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 14:20:26 2002","","No significant hits to the NCBI PDB database.","SMU.2044c","","Residues 50 to 149 (E-value = 2.2e-10) place SMu1856 in the HD family which is described as HD domain (PF01966)Residues 240 to 351 (E-value = 2.1e-75) place SMu1856 in the RelA_SpoT family which is described as Region found in RelA / SpoT proteins (PF04607)Residues 391 to 454 (E-value = 8.5e-30) place SMu1856 in the TGS family which is described as TGS domain (PF02824)Residues 664 to 738 (E-value = 4.4e-06) place SMu1856 in the ACT family which is described as ACT domain (PF01842)","Thu Aug 24 10:03:26 2006","","","Mechold,U., Steiner,K., Vettermann,S. and Malke,H. Genetic organization of the streptokinase region of the Streptococcus equisimilis H46A chromosome Mol. Gen. Genet. 241 (1-2), 129-140 (1993) PubMed: 8232196.","","Tue Jan 8 14:20:26 2002","","1","","","SMU.2044c","191" "SMu1857","1920158","1919337","822","ATGGTTAAGTTATTAACAATCAATAGCCATAGTTGGATGGAAGAAGACCCACAAAAGAAATTAGAGATTTTAGGAAAAACAATTCTTGAAAATGATTATGATGTTATTTGCGTTCAAGAGGTGAATCAGCTTTTGCATTCAGAACCTGCTAAAGATTTGCCTAATTATTGTCAAGTGGCAGGAACTCCAGCCATTCATAAGGACAATTATGCTCTACAATTGGTGACTTTTTTATTGGAACAAGAGAGAGTTTATTATTGGTCTTGGGCTTATAATCATATCGGCTATGATCGTTTTCAAGAAGGCGTAGCTATTTTATCCAAAACACCGCTTGTCAGTCAGGGGATCCTCATATCAGATGTAGATGATGAGCATGACTACCATACAAGACGGGCTCTTTTAGGAAAAACGAAAATTGATCAAGAGGATATCGCTATTGTCAGTCTTCATATGTCTTGGTGGAACAAGGGGTTTCAAGGAGAATGGAACAAATTGGAAAGAGTACTGTCCAACCTAAAGCTTCCCTTACTTTTAATGGGGGATTTTAACAACCCTTATGAAAATGAAGGGTATCAAGCAATTCTAAAAAGTTCACTGAAGTTACAAGATAGCCACCAGTCAGCTAAAATTACTTATGGCAAAGCCACTATCCAAAAGGAAATTGATGGTTGGCAAGGTAATCAAGAAGCCCTCAAAGTTGATTATGTTTTCCTAAGTTCAGATTGGCAGGTGGAAAAATCAGAAGTTATTTTTGATGGGAAACATTACCCAATGATTAGTGATCACTGTGGTTTAGCCTGCCAAGCAAATTTGAATAAATAA","5.30","-9.77","31418","MVKLLTINSHSWMEEDPQKKLEILGKTILENDYDVICVQEVNQLLHSEPAKDLPNYCQVAGTPAIHKDNYALQLVTFLLEQERVYYWSWAYNHIGYDRFQEGVAILSKTPLVSQGILISDVDDEHDYHTRRALLGKTKIDQEDIAIVSLHMSWWNKGFQGEWNKLERVLSNLKLPLLLMGDFNNPYENEGYQAILKSSLKLQDSHQSAKITYGKATIQKEIDGWQGNQEALKVDYVFLSSDWQVEKSEVIFDGKHYPMISDHCGLACQANLNK","1919355","","conserved hypothetical protein","Cytoplasm","Few strong matches in gapped BLAST to conserved hypothetical proteins; residues 1-265 are 55% similar to hypothetical protein of Streptococcus pyogenes (gi|15675775).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1958 (1e-84).","

InterPro
IPR005135
Domain

Endonuclease/exonuclease/phosphatase
PF03372	$\"[2-269]T$	Exo_endo_phos

noIPR
unintegrated

unintegrated
SSF56219	$\"[1-270]T$	SSF56219

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:30:48 2002","Tue Jan 8 14:06:41 2002","Tue Jan 8 14:05:41 2002","Tue Jan 8 14:05:41 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1857 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Jan 8 14:06:41 2002","","No significant hits to the NCBI PDB database.","SMU.2046c","","Residues 2 to 269 (E-value = 2e-13) place SMu1857 in the Exo_endo_phos family which is described as Endonuclease/Exonuclease/phosphatase family (PF03372)","Tue Jan 8 14:05:41 2002","24380384","","","","","","1","","","SMU.2046c","732" "SMu1858","1922438","1920249","2190","ATGAAAAATTATAAACAACTTTTTAGCTTCGAATTTTGGCAAAAATTCGGAAAATGTTTAATGGTTGTTATTGCTGTTATGCCTGCAGCAGGTTTGATGGTTTCTATTGGGAATTCATTAGCCTTGATTGACCCTAAATCAACCCTTTTAGTGACTGTTGCTAATATCATTGCCCAAATTGGTTGGGGTGTTATTAACAACCTTCATATTTTATTTGCTGTGGCTATCGGGGGTAGCTGGGCTAAGGAACGTGCAGGTGGAGCTTTCGCTGCAGCCCTTGCCTTTATTTTGATTAACCTTATTACTGGTAACTTTTATGGCATATCGCTTGAGATGATTGCGGATAAAACAAGTTATGTACACAATATCTTTGGCGGTAAGATGCACGTTGCTGATTACTTTATCAATGTACTTGGCCAACCTGCCTTGAACATGGGAGTTTTCGTTGGTATTATCTCTGGTTTCGTTGGCGCAACAGCTTATAACAAGTATTATAATTTCCGTAAACTTCCAGATGTTTTATCGTTCTTTAACGGAAAACGCTTTGTACCTTTTGTCGTTATTGTTCGTTCAACAATTGTTGCTTTAATTCTTTCTGTATTTTGGCCAATTGTACAATCTGGTATTAATGGTTTTGGTATGTGGATTGCTTCTTCACAACATACCGCACCGTTTCTTGCGCCATTCCTTTATGGTACTTTAGAACGTTTACTGTTGCCATTTGGTTTACACCATATGTTAACGATTCCAATGAATTATACCCAACTCGGTGGTACTTATGTTGTCTTGACAGGTGCTCAAGCAGGAAAACATGTGCTTGGACAAGATCCACTTTGGTTAGCTTGGGTGCAAGACCTTATCCATCTTAAAGGTGCAGGTCATATGTCTCAATACCATCACTTGTTAACATCTGTAACTCCTGCTCGTTTCAAGGTAGGACAAATGATTGGTTCATCAGGTATTCTTATGGGACTTACATTGGCGATGTACCGCAATGTTGACCCAGATAAAAAAGAAAAATATAAAGGGATGTTCCTTTCAGCAGCTGTTGCCGTATTCTTAACAGGGGTAACAGAACCACTTGAATACATGTTTATGTTTGCAGCTTTACCGCTCTATCTTGTTTACGCTGTTGTTCAAGGTTTGGCCTTTGCATCAGCCGATTTGATTCACCTTCGTGTGCATTCATTTGGTAATATTGAGTTTCTGACGAGAACGCCAATGGCTATCAAAGCCGGTTTAGCTATGGATATTGTCAACTTTATCGTTGTTTCAGTTGTCTTTGGTGTTGCTATGTACTTCATTACCAACTTTATGATTAAGAAGTTTAATTTGGCAACTTCAGGACGTAATGGCAATTATGATACAGGTGATGATGCTTCTGACGAAACAGCTTCAAATAGTAATGCAGGAACAGCAAATGCTAATTCACAAATTGTAAAAATTATCAATCTTTTAGGTGGTAAAGAAAATATCTCTGATGTTGATGCTTGTATGACCCGCCTGCGTATTACTGTGACCGATGTTGCTAAAGTGGGTGATGAAGCTGCTTGGAAAAAAGCAGGAGCTATGGGCTTAATTGTCAAAGGCAATGGTGTTCAAGCCGTTTATGGTCCTAAGGCAGATGTCCTTAAATCTGATATTCAGGATTTATTAGATTCAGGAGTGGACATTCCTAAGACAGATGTTACAGCTCTAGAAGAAGATAAGACAGCAGATGTCAGCTTCAAAGGAGTTACAGAAGAAATAGCAACTGTGGCAGATGGTCAAGTACTTCCAATTACACAAGTACATGACCCAGTCTTCTCACAAAAAATGATGGGCGATGGTTTCGCTGTTGAGCCAGAAAATGGCAATATCTACTCTCCAGTAGCTGGTTTAGTAACTAGTGTCTTCCCAACCAAACATGCTCTTGGTCTTTTAACGGATGATGGACTTGAAGTTTTAGTTCATGTCGGTTTAGATACTGTTGCTCTTAATGGAGCTCCATTCTCTGCTAAGGTGAAAGATGGCCAACGTGTTGCATTAGGAGACTTACTTCTAGTTGCTGATTTGGAAGCTATCAAATCTGCAGATCGTGAAACAACTGTTATTGTTGCCTTTACAAATACAGCAGAACTTAAGTCTGTAACGCTTGAGAAAACAGGTCAACAAGCTGCTAAAACAGTTGTCGCCAAAGTAGAACTTTAA","7.00","0.00","78411","MKNYKQLFSFEFWQKFGKCLMVVIAVMPAAGLMVSIGNSLALIDPKSTLLVTVANIIAQIGWGVINNLHILFAVAIGGSWAKERAGGAFAAALAFILINLITGNFYGISLEMIADKTSYVHNIFGGKMHVADYFINVLGQPALNMGVFVGIISGFVGATAYNKYYNFRKLPDVLSFFNGKRFVPFVVIVRSTIVALILSVFWPIVQSGINGFGMWIASSQHTAPFLAPFLYGTLERLLLPFGLHHMLTIPMNYTQLGGTYVVLTGAQAGKHVLGQDPLWLAWVQDLIHLKGAGHMSQYHHLLTSVTPARFKVGQMIGSSGILMGLTLAMYRNVDPDKKEKYKGMFLSAAVAVFLTGVTEPLEYMFMFAALPLYLVYAVVQGLAFASADLIHLRVHSFGNIEFLTRTPMAIKAGLAMDIVNFIVVSVVFGVAMYFITNFMIKKFNLATSGRNGNYDTGDDASDETASNSNAGTANANSQIVKIINLLGGKENISDVDACMTRLRITVTDVAKVGDEAAWKKAGAMGLIVKGNGVQAVYGPKADVLKSDIQDLLDSGVDIPKTDVTALEEDKTADVSFKGVTEEIATVADGQVLPITQVHDPVFSQKMMGDGFAVEPENGNIYSPVAGLVTSVFPTKHALGLLTDDGLEVLVHVGLDTVALNGAPFSAKVKDGQRVALGDLLLVADLEAIKSADRETTVIVAFTNTAELKSVTLEKTGQQAAKTVVAKVEL","1920267","For other 'pts' genes see SMu0617 (ptsI) and SMu0685 (ptsK).From GenBank (gi:131493): In B. subtilis, this is a component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system. The IICD domains contain the sugar binding site and the transmembrane channel; the IIA domain contains the primary phosphorylation site (the donor is phospho-HPR); IIA transfers its phosphoryl group to the IIB domain which finally transfers it to the sugar. The reaction: protein N-phosphohistidine + sugar = protein histidine + sugar phosphate. This is an integral membrane complex containing EIIA, EIIB, and EIIC domains.","PTS system, enzyme II, A component","Membrane, Cytoplasm","The C-terminal portion of this protein is nearly identical to a previously sequenced protein, putative ptsG protein (gi|4098489), submitted to GenBank by Peruzzi, et al.Many strong matches in gapped BLAST to PTS system, enzyme II, A component; residues 3-729 are 66% similar to PTS system, enzyme II, A component of Streptococcus pyogenes (gi|15675776); residues 4-729 are 62% similar to PTS glucose-specific enzyme IIABC component of Streptococcus pneumoniae (gi|15902712).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1959 (0.0).","

InterPro
IPR001127
Domain

Phosphotransferase system, sugar-specific permease EIIA 1 domain
PD002243	$\"[586-703]T$	PTS_EIIA
PF00358	$\"[578-710]T$	PTS_EIIA_1
TIGR00830	$\"[583-703]T$	PTBA
PS00371	$\"[645-657]T$	PTS_EIIA_TYPE_1_HIS
PS51093	$\"[599-703]T$	PTS_EIIA_TYPE_1

InterPro
IPR001996
Domain

Phosphotransferase system, EIIB
PF00367	$\"[480-513]T$	PTS_EIIB
PS01035	$\"[491-508]T$	PTS_EIIB_TYPE_1_CYS
PS51098	$\"[476-558]T$	PTS_EIIB_TYPE_1

InterPro
IPR003352
Domain

Phosphotransferase system, EIIC
PF02378	$\"[17-381]T$	PTS_EIIC

InterPro
IPR011055
Domain

Duplicated hybrid motif
SSF51261	$\"[574-728]T$	Dup_hybrid_motif

InterPro
IPR011300
Domain

Phosphotransferase system, IIBC component
TIGR02003	$\"[6-554]T$	PTS-II-BC-unk1

InterPro
IPR011535
Domain

Phosphotransferase system, glucose-like IIB component
TIGR00826	$\"[441-538]T$	EIIB_glc

InterPro
IPR013013
Domain

Phosphotransferase system, EIIC component, type 1
PS51103	$\"[7-452]T$	PTS_EIIC_TYPE_1

noIPR
unintegrated

unintegrated
G3DSA:2.70.70.10	$\"[569-722]T$	G3DSA:2.70.70.10
G3DSA:3.30.1360.60	$\"[464-565]T$	G3DSA:3.30.1360.60
SSF55604	$\"[478-556]T$	SSF55604

","BeTs to 4 clades of COG1263COG name: Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specificFunctional Class: GThe phylogenetic pattern of COG1263 is --------EB----gpO----Number of proteins in this genome belonging to this COG is 1","***** IPB001127 (Sugar-specific permease, EIIA 1 domain) with a combined E-value of 5.1e-42. IPB001127A 583-617 IPB001127B 622-664***** IPB001996 (PTS (phosphotransferase system) EIIB domain) with a combined E-value of 4.2e-19. IPB001996A 479-513 IPB001996B 529-541","Residues 483-552 are 41% similar to a (PROTEOME SYSTEM TRANSFERASE) protein domain (PD308452) which is seen in Q9HXN4_PSEAE.Residues 53-402 are 30% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE PTS) protein domain (PD001764) which is seen in Q57071_STACA.Residues 515-554 are 55% similar to a (PROTEOME COMPONENT SYSTEM COMPLETE) protein domain (PD165075) which is seen in O51590_BORBU.Residues 599-703 are 48% similar to a (COMPONENT SYSTEM PHOSPHOTRANSFERASE TRANSPORT PTS IIABC) protein domain (PD002243) which is seen in Q9CGG4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 18:20:10 2002","Tue Jan 8 12:08:14 2002","Thu Oct 10 18:20:10 2002","Tue Jan 8 12:08:14 2002","Tue Jan 8 12:08:14 2002","Tue Jan 8 12:08:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1858 is paralogously related (blast p-value < 1e-3) to SMu1852 ,a predicted phosphotransferase system, trehalose-specific IIBC component (EIIBC-tre); SMu1677,a predicted PTS system, sucrose- specific IIABC component; and SMu0890, a predicted beta-glucoside -specific EII permease.","Mon Apr 15 09:40:17 2002","Tue Jan 8 12:08:14 2002","pdb|1AX3| Solution Nmr Structure Of B. Subtilis Iiaglc, 16 S... 113 6e-026pdb|2GPR| Glucose Permease Iia From Mycoplasma Capricolum 98 4e-021pdb|1GGR|A Chain A, Complex Of Enzyme Iiaglc And The Histidine-... 87 7e-018","SMU.2047c","","Residues 17 to 381 (E-value = 1.6e-40) place SMu1858 in the PTS_EIIC family which is described as Phosphotransferase system, EIIC (PF02378)Residues 480 to 513 (E-value = 4.3e-15) place SMu1858 in the PTS_EIIB family which is described as phosphotransferase system, EIIB (PF00367)Residues 599 to 703 (E-value = 8.1e-52) place SMu1858 in the PTS_EIIA_1 family which is described as phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PF00358)","Tue Jan 8 12:08:14 2002","",""," Abranches J, Candella MM, Wen ZT, Baker HV, Burne RA.Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans.J Bacteriol. 2006 Jun;188(11):3748-56. PMID: 16707667Peruzzi,F., Piggot,P.J. and Daneo-Moore,L. Development of an integrative, lacZ transcriptional-fusion plasmid vector for Streptococcus mutans and its use to identify sugar regulated genes. Unpublished.","Sutrina,S.L., Reddy,P., Saier,M.H. Jr. and Reizer,J. The glucose permease of Bacillus subtilis is a single polypeptide chain that functions to energize the sucrose permease. J. Biol. Chem. 265 (30), 18581-18589 (1990) PubMed: 2120236.Liao,D.I., Kapadia,G., Reddy,P., Saier,M.H. Jr., Reizer,J. and Herzberg,O. Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolution. Biochemistry 30 (40), 9583-9594 (1991) PubMed: 1911744.","Thu Apr 4 11:39:56 2002","Tue Jan 8 12:26:36 2002","1","","","SMU.2047c","488" "SMu1859","1922836","1922988","153","TTGAAAAGATGTACCAAGCTGACAGCCGACTATGCTCAACATTCCTACAACACTAACCGTAAGCAATCTGTAAAGCCTGTGACTTATGATAAAGAAACACAGGAGAAAATCAAATCCTGCATTACCTTAAGCAGAAGTTCTCTCCTGAAATGA","10.60","7.12","5787","MKRCTKLTADYAQHSYNTNRKQSVKPVTYDKETQEKIKSCITLSRSSLLK","1923000","","hypothetical protein","Extracellular, Cytoplasm","No significant matches in gapped BLAST.SMu1859 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:30:12 2002","Tue Jan 8 11:58:06 2002","Tue Jan 8 11:58:06 2002","Tue Jan 8 11:58:06 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1859 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:30:12 2002","","No significant hits to the NCBI PDB database.","SMU.2048","","No significant hits to the Pfam 11.0 database","Tue Jan 8 11:58:06 2002","24380386","","","","","","1","","","SMU.2048","" "SMu1860","1924020","1923277","744","ATGCAGCAGTATTTTGTAAATGGCAAAGCTGACAAGCTGGTCACGATTACTGATAAGGATACTATCAAGCATATGTTTAATGTCATGCGCTTGACTGAGGATGACGAAGTGGTGCTGGTTTTTGATGATGGAATCAAACGTTTGGCGCGTGTGACCAATGTCCAAGAACACACTTTTGAAATTGTAGATGAGCTATCTGACAATGTGGAATTACCTGTCCAAGTCGTTATCGCTTCAGGATTCCCCAAAGGAGATAAATTGGAATTTCTTGCCCAAAAGACGACTGAGCTGGGTGCGCATGCTCTCTGGGCCTTTCCAGCTGATTGGTCTGTCGTTAAATGGGATAGTAAAAAATTGCTCAAAAAAGCCGATAAGCTGACTAAGATTGCCCAAGGAGCGGCTGAACAGTCCAAACGCAATATCATTCCGCAAGTCAAATTTTTTGAGAAAAAGTCTGACTTTCTGACTCAGTTGGCCGTATTTAATAAAATCTTCGTTGCCTATGAAGAATCTGCTAAAATCGGTGAAAGCGCAGCTCTGGCGCGTGAACTAGCACAACTGAGCGCAGACCAGCAAATTCTTTTCATTTTCGGTCCGGAAGGCGGCCTTTCACCAGCGGAGATAGCAGCCTTTGAGAAAGCTGGGGCTGTTAAAGTTGGACTAGGTCCCCGCATCATGCGAACAGAAACAGCTCCGTTGTTTGCTTTAAGCAGTATTAGTTATGTTCTGGAATTAGCAAAATAA","5.90","-2.26","27376","MQQYFVNGKADKLVTITDKDTIKHMFNVMRLTEDDEVVLVFDDGIKRLARVTNVQEHTFEIVDELSDNVELPVQVVIASGFPKGDKLEFLAQKTTELGAHALWAFPADWSVVKWDSKKLLKKADKLTKIAQGAAEQSKRNIIPQVKFFEKKSDFLTQLAVFNKIFVAYEESAKIGESAALARELAQLSADQQILFIFGPEGGLSPAEIAAFEKAGAVKVGLGPRIMRTETAPLFALSSISYVLELAK","1923295","","conserved hypothetical protein","Cytoplasm, Membrane","Many matches in gapped BLAST to conserved hypothetical protein; residues 1-245 are 64% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675777).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1968 (3e-95).","

InterPro
IPR006700
Family

Protein of unknown function DUF558, methyltransferase predicted
PF04452	$\"[14-241]T$	DUF558
TIGR00046	$\"[18-246]T$	DUF558_mtase_pred

noIPR
unintegrated

unintegrated
G3DSA:2.40.240.20	$\"[1-68]T$	G3DSA:2.40.240.20
G3DSA:3.40.1280.10	$\"[69-244]T$	G3DSA:3.40.1280.10
PIRSF015601	$\"[3-246]T$	MT_UPF0088
SSF75217	$\"[68-247]T$	SSF75217
SSF88697	$\"[2-61]T$	SSF88697

","BeTs to 9 clades of COG1385COG name: Uncharacterized BCRFunctional Class: SThe phylogenetic pattern of COG1385 is -----qvcebrhuj--OL--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 30-115 are 45% similar to a (PROTEOME COMPLETE PA0419 NMB1925) protein domain (PD081730) which is seen in Q9KD69_BACHD.Residues 24-100 are 46% similar to a (PROTEOME COMPLETE BU410 DNAJ-RPSU) protein domain (PD010785) which is seen in Q9S5A1_LISMO.Residues 4-106 are 41% similar to a (PROTEOME COMPLETE UU301 SLR0722) protein domain (PD292929) which is seen in Q9CJ96_LACLA.Residues 129-239 are 53% similar to a (COMPLETE PROTEOME BB0062 PA0419) protein domain (PD008210) which is seen in Q9CJ96_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:29:48 2002","Tue Jan 8 11:56:59 2002","Tue Jan 8 11:56:59 2002","Tue Jan 8 11:56:59 2002","","Tue Jan 8 11:56:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1860 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:29:48 2002","","No significant hits to the NCBI PDB database.","SMU.2049c","","Residues 127 to 240 (E-value = 1.6e-47) place SMu1860 in the DUF558 family which is described as Protein of unknown function (DUF558) (PF04452)","Tue Jan 8 11:56:59 2002","24380387","","","","","","1","","","SMU.2049c","489" "SMu1861","1924974","1924021","954","ATGGACAAATGGCAAGAATTAACCATCACAGTCAATCGTGAGGCAGAAGAAGCGGCCTCCAATATTTTAATCGAATGTGGCAGTCAAGGCGTAGTCATTGATGATAGTGCGGACTACCTTGGTAAGGTTGGTAAGTATGGCGAAGTTTTTCCAGAGGTGGAACAAGTGGAAATGGTTACCATTACTGCCTACTATCCTGAATCTGCTGATATGACAGTCATTACCGCACAGGTCAATGAGCGCTTAGCAGAATTAACCGATTTCGGTCTGCAGACAGGTCAGGTGCAGTTGACTACTCAGGAGCTGGCTGAGGAAGACTGGGCAGAAAACTGGAAAAAGTATTATGAGCCTACTCGTATCACCCATGACTTGACTATTGTGCCTAGCTGGACTGATTATGAAGTCCAAGCAGGTGAGAAAATCATCAAACTTGACCCCGGCATGGCTTTCGGCACAGGTACCCATCCGACAACCAAGATGAGCCTCTTTGCTTTGGAGCAGGTCTTGCGAGGTGGCGAAACGGTTATTGATGTCGGTACTGGAAGTGGGGTACTTTCCGTTGCTAGCTCACTTCTGGGTGCCAAGGAGATCTTCGCTTACGACTTAGATGATGTAGCGGTGCGCGTGGCTCAAGAAAATATTGATCTCAATGTTGGGACTGAAAACATTCATGTGACAGCGGGTGATCTACTCAAGGGTATTGCGATTGAAGCGGACGTTATTGTAGCTAACATTTTGGCAGATATACTGGTCAATCTGACGGATGATGCCTATCGTCTCGTTAAGGACGAGGGTTATCTCATCATGTCCGGTATTATTTCAGAAAAATTAGATATGGTTCTTGAAGCGGCTCACAGCGCAGGCTTTTTCCTTGAAACCCACATGATTCAAGGCGAATGGAATGCCCTTGTCTTCAAGAAAACCGATGCTATTTCAGGCGTGATTGGAGGATAA","4.10","-31.80","34530","MDKWQELTITVNREAEEAASNILIECGSQGVVIDDSADYLGKVGKYGEVFPEVEQVEMVTITAYYPESADMTVITAQVNERLAELTDFGLQTGQVQLTTQELAEEDWAENWKKYYEPTRITHDLTIVPSWTDYEVQAGEKIIKLDPGMAFGTGTHPTTKMSLFALEQVLRGGETVIDVGTGSGVLSVASSLLGAKEIFAYDLDDVAVRVAQENIDLNVGTENIHVTAGDLLKGIAIEADVIVANILADILVNLTDDAYRLVKDEGYLIMSGIISEKLDMVLEAAHSAGFFLETHMIQGEWNALVFKKTDAISGVIGG","1924039","","ribosomal protein L11 methylase","Cytoplasm","Many strong matches in gapped BLAST to Ribosomal protein L11 methylase; residues 1-317 are 71% similar to ribosomal protein L11 methyltransferase of Streptococcus pneumoniae (gi15901611); residues 1-317 are 60% similar to methyltransferase of Lactococcus lactis (gi15672085).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1969 (1e-131).","

InterPro
IPR004498
Family

Ribosomal protein L11 methyltransferase
PIRSF000401	$\"[2-309]T$	L11_MTase
TIGR00406	$\"[4-301]T$	prmA

InterPro
IPR010456
Family

Ribosomal L11 methyltransferase
PF06325	$\"[3-308]T$	PrmA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.150	$\"[118-308]T$	G3DSA:3.40.50.150
PTHR18895	$\"[156-308]T$	PTHR18895
PTHR18895:SF3	$\"[156-308]T$	PTHR18895:SF3
SSF53335	$\"[99-307]T$	SSF53335

","BeTs to 6 clades of COG2264COG name: Ribosomal protein L11 methylaseFunctional Class: JThe phylogenetic pattern of COG2264 is -----qvcebrhuj--OL--xNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 231-307 are 74% similar to a (METHYLTRANSFERASE 2.1.1.- COMPLETE) protein domain (PD010963) which is seen in Q9CJ97_LACLA.Residues 104-162 are 78% similar to a (METHYLTRANSFERASE RIBOSOMAL COMPLETE) protein domain (PD009497) which is seen in Q9CJ97_LACLA.Residues 4-88 are 49% similar to a (METHYLTRANSFERASE PROTEOME COMPLETE) protein domain (PD033740) which is seen in Q9CJ97_LACLA.Residues 109-170 are 41% similar to a (METHYLTRANSFERASE RIBOSOMAL PROTEOME) protein domain (PD392289) which is seen in Q9X0G8_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 13:07:45 2002","Thu Apr 11 09:15:23 2002","Tue Sep 19 16:44:48 2006","Tue Jan 8 11:49:12 2002","","Tue Jan 8 11:49:12 2002","no","Thu Oct 10 18:03:47 2002","SMu1861 is paralogously related (blast p-value < 1e-3) to SMu0992 , a predicted protoporphyrinogen oxidase.","Mon Apr 15 13:07:45 2002","","No significant hits to the NCBI PDB database.","SMU.2050c","","Residues 3 to 308 (E-value = 8.1e-167) place SMu1861 in the PrmA family which is described as Ribosomal protein L11 methyltransferase (PrmA) (PF06325)","Tue Jan 8 11:49:12 2002","24380388","","","","","","1","","","SMU.2050c","490" "SMu1862","1925417","1925202","216","TTGGTTATTAACCACGCCAATGCGATCTCGGTAAAATCCTATACTGTAACCTTTTTAGGTCTGCCGCTGTATGACATTGTACTAAATGATAAGATTTATGCAGGAACAGCAATTGGTTCCAACATTGGAACTCTTTGTAGCTTCTTTGCTTTCGTTGCTTTAATGATCGAAGAAGTCTGGCTGCGTTTGGTGAGAAGAAGACAAAAATGCTCGTGA","9.50","3.12","7918","MVINHANAISVKSYTVTFLGLPLYDIVLNDKIYAGTAIGSNIGTLCSFFAFVALMIEEVWLRLVRRRQKCS","1925220","","hypothetical protein","Membrane, Cytoplasm","No significant matches in gapped BLAST.SMu1862 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
tmhmm	$\"[32-52]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
PS51257	$\"[1-19]T$	PROKAR_LIPOPROTEIN

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[50-132]T$	Acetyltransf_1
PS51186	$\"[1-158]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[1-157]T$	G3DSA:3.40.630.30
PTHR23091	$\"[6-131]T$	PTHR23091
PTHR23091:SF1	$\"[6-131]T$	PTHR23091:SF1
SSF55729	$\"[1-159]T$	SSF55729

","BeTs to 4 clades of COG0454COG name: Predicted acetyltransferasesFunctional Class: RThe phylogenetic pattern of COG0454 is AmTKYqVCEBR-uj----in-Number of proteins in this genome belonging to this COG is 8","***** IPB000182 (GCN5-related N-acetyltransferase) with a combined E-value of 9.5e-07. IPB000182A 88-97 IPB000182B 125-131","Residues 1-84 are 35% similar to a (TRANSFERASE PROTEOME ACETYL COMPLETE) protein domain (PD391316) which is seen in Q9CJA2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Feb 6 13:35:45 2007","Tue Feb 6 13:35:45 2007","Tue Feb 6 13:35:45 2007","Tue Jan 8 11:34:16 2002","Tue Jan 8 11:34:16 2002","Tue Jan 8 11:34:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1865 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 10 18:02:37 2002","","No significant hits to the NCBI PDB database.","SMU.2055","","Residues 50 to 132 (E-value = 1.3e-14) place SMu1865 in the Acetyltransf_1 family which is described as Acetyltransferase (GNAT) family (PF00583)","Tue Jan 8 11:34:16 2002","24380392","","","","","","1","","","SMU.2055","" "SMu1866","1926593","1927876","1284","ATGATTTGGAGGCTGCCTATGCCAAATAACCTCGCACTTCGTATGCGCCCTCGAGATATCTCTGAAGTTATCGGACAAAAGCATCTAGTCGGTCAAGGCAAGATTATTTCGCGAATGGTCACTGCTAACCGTCTGTCTTCCATGATTCTTTATGGCCCTCCCGGAATTGGAAAAACCTCAATCGCTTCTGCCATCGCTGGTACAACCAAATTTGCCTTTCGTACCTTCAATGCAACAACCGACACTAAAAAACGCCTGCAGGAAATTGCTGAAGAAGCTAAATTTTCAGGTGGTTTGGTCTTGCTCCTAGATGAAATTCATCGTCTAGATAAAACTAAGCAAGATTTTCTTCTCCCCTTGTTGGAAAACGGACAAATTATCATGATTGGCGCAACCACTGAAAATCCCTTTTTCTCTGTCACCCCTGCCATTCGCTCGCGTGTTCAGATTTTTGAGTTAGAGCCATTATCAAATGAGGATATCAAAAAAGCTATGCAAGCAGCTCTGACAGATACAGAGCGCGGCTTTGATTTTGAAGTCAAATTAGATGATGATGCTCTTGACTTCATTGCGCAAGCCACCAATGGCGACTTGCGCTCTGCCTATAATTCTCTTGATTTAGCCATCATGTCCACCCAGCCAGATGACAATGGTAGTCGCCACATCACCTTAGACACTGTTGAAAACAGCCTACAGCGCAGCTACATTACCATGGACAAGGATGGTGATGGCCACTATGATGTCTTGTCCGCCTTACAAAAATCTATTCGCGGTTCAGATGTCAATGCCAGCCTTCACTATGCTGCCAGATTAATCGAAGCTGGTGATCTGCCAAGTCTAGCTAGACGTTTAACCATTATTGCTTACGAAGATATCGGCTTAGCCAATCCTGATGCACAGATTCATACAGTGACAGCGCTGGAAGCAGCCCAAAAAATTGGTTTTCCTGAAGCCCGCATTTTAATTGCCAATGTTGTTATTGATTTAGCACTCTCACCTAAGTCTAATTCCGCTTATGTTGCTATGGACAAGGCCATTGCAGATCTTCATAAAAGCGGCACGATCCCTATTCCTCGCCACTTACGTGATGGTCATTACGCTGGCAGTAAAGAATTGGGCAATGCCCAAGATTATCTCTACCCGCATGCCTATCCGGAAAAATGGGTTAAGCAGCAATATTTACCAGACAAACTCAAAGGAGCTAACTATTTTACTGCCAATGAAACAGGTAAATACGAACGGGCACTGGGGGCTAACAAAGACAAGATTGATAAACTTTCATAA","6.70","-1.57","47156","MIWRLPMPNNLALRMRPRDISEVIGQKHLVGQGKIISRMVTANRLSSMILYGPPGIGKTSIASAIAGTTKFAFRTFNATTDTKKRLQEIAEEAKFSGGLVLLLDEIHRLDKTKQDFLLPLLENGQIIMIGATTENPFFSVTPAIRSRVQIFELEPLSNEDIKKAMQAALTDTERGFDFEVKLDDDALDFIAQATNGDLRSAYNSLDLAIMSTQPDDNGSRHITLDTVENSLQRSYITMDKDGDGHYDVLSALQKSIRGSDVNASLHYAARLIEAGDLPSLARRLTIIAYEDIGLANPDAQIHTVTALEAAQKIGFPEARILIANVVIDLALSPKSNSAYVAMDKAIADLHKSGTIPIPRHLRDGHYAGSKELGNAQDYLYPHAYPEKWVKQQYLPDKLKGANYFTANETGKYERALGANKDKIDKLS","1927888","","chromosome segregation helicase (ATPase related to the helicase subunit of the Holliday junction resolvase)","Cytoplasm","Numerous strong matches in gapped BLAST to chromosome segregation helicases; residues 7-426 are 83% similar to chromosome segregation helicase of Streptococcus pneumoniae (gi|15903658); residues 7-425 are 71% similar to chromosome segregation helicase of Lactococcus lactis (gi|15672079).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1978 (0.0).","

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[44-156]T$	AAA

InterPro
IPR003959
Domain

AAA ATPase, core
PF00004	$\"[47-151]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[11-156]T$	G3DSA:3.40.50.300
PTHR13779	$\"[19-425]T$	PTHR13779
PTHR13779:SF1	$\"[19-425]T$	PTHR13779:SF1
SSF52540	$\"[10-300]T$	SSF52540

","BeTs to 6 clades of COG2256COG name: Uncharacterized ATPase related to the helicase subunit of the Holliday junction resolvaseFunctional Class: LThe phylogenetic pattern of COG2256 is ----y-v-ebrhuj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 11-66 are 73% similar to a (PROTEOME COMPLETE ATP-BINDING HELICASE) protein domain (PD342630) which is seen in O34528_BACSU.Residues 22-126 are 85% similar to a (ATP-BINDING PROTEASE SUBUNIT PROTEOME COMPLETE) protein domain (PD000092) which is seen in Q9CJA3_LACLA.Residues 16-66 are 78% similar to a (SUBUNIT REPLICATION DNA FACTOR ACTIVATOR ATP-BINDING) protein domain (PD022232) which is seen in Q9KDF6_BACHD.Residues 121-175 are 65% similar to a (PROTEOME COMPLETE ATP-BINDING HELICASE) protein domain (PD251703) which is seen in O34528_BACSU.Residues 67-119 are 58% similar to a (PROTEOME COMPLETE YRVN BH1257) protein domain (PD330962) which is seen in O34528_BACSU.Residues 178-371 are 69% similar to a (PROTEOME COMPLETE ATP-BINDING HELICASE) protein domain (PD006874) which is seen in Q9CJA3_LACLA.Residues 372-424 are 50% similar to a (PROTEOME COMPLETE HELICASE HELICASE-LIKE) protein domain (PD026875) which is seen in Q9CJA3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 13:19:27 2002","Tue Jan 8 11:21:30 2002","Thu Oct 10 18:02:03 2002","Tue Jan 8 11:21:30 2002","","Tue Jan 8 11:21:30 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1866 is paralogously related (blast p-value < 1e-3) to SMu1437, a predicted DNA polymerase III subunits gamma / tau; SMu0058,a predicted holliday junction DNA helicase; SMu0868,a predicted ATP-dependent Clp protease, ATP-binding subunit;SMu0511,a predicted ATP-dependent protease ClpE; SMu1844,a predicted ATP-dependent Clp protease, ATP-binding subunit (Class III stress response-related ATPase) and SMu0013, a predicted cell division protein FtsH.","Mon Apr 15 13:19:27 2002","","No significant hits to the NCBI PDB database.","SMU.2056","","Residues 47 to 203 (E-value = 6.8e-17) place SMu1866 in the AAA family which is described as ATPase family associated with various cellular activities (AAA) (PF00004)","Tue Jan 8 11:21:30 2002","24380393","","","","Mon Apr 15 13:19:27 2002","","1","","","SMU.2056","192" "SMu1867","1930142","1928283","1860","ATGCCAGTAACCTTTTTCTTTTTAGGGTTAATATTATTTATTGCGGGACTTTTGCCCAATTTTACTCCTGAGGTCAAAAATAGTCTAACTATCTTGGCCTTGCTGACTGCTGGTTATCATGTTATCTGGGAGGGTGTTGAAGACACTGTTGAGCAATCCAAAAAAGCCAACTGTTTTGTTCCTAACACGCATATATTGATGGCGTTGGCAGCTTTAGGTGCTGTTTTATTGGGAGAAACAACAGAAGCAGCTCTTCTTATCTTCATCTTTGCTGGTGCACACTTTTTAGAAAAGTATGTTGAAGGTTGTAGTCAACGTGAAATCACAAAACTATTAGAGCTTAATCCAACAGAAGCCAGACGTTTGACAAATACCAATGAAATTGAAATGATTTCTGTTGATCAGCTTAAGATTGGGGACTGTGTTCAGGTTTTAAATGGCGGACAGGTGCCAGCGGATGGAAAAATTCTAGAAGGATACACTAGCATTGACGAATCAACGATTACTGGAGAATCCATTCCATACGAAAAAACAGTTGGTGATGAAGTTTATGCCTCAACGATTAATGGATCTGGAACGATTATTGTAGAAGTCAGCAAAGACAGTTCACAGACTGTATTTGCCAAAATTTTACAGTTAGTTGAAGCTTCTCAGGGTCATTTTTCACCTGCTGCTAAGCGTCTTAATCGCTTTGAACCCATTTATGTTAGCATTGTTCTCCTCGCTTTTATTGGTTTACTTATTTCAGGACCTTTATTTTGGAATTGGGCTTGGACAAAAACAATTTCGATTAGTTTGACTTTTTTAGTATCAGCTTCTCCTTGTGCCTTGGCAGTATCAGTCATCCCAGCAACATTAGCTGGCATTTCAAATTTAGCACGGCAAGGTGTCTTATTTAAAGGTGGCTGTTTCCTTTCTGATTTAACGGCTATCAAAATGATTGCCTTTGATAAAACAGGGACTTTGACAGAAGGGAAACCAAAAGTGGTCACTAGTCAATTTCTTCTTTCTGATATTTCCAAAGAAAAATTCGAAGCAGTCTTAGTAGCTATGGAAAGTCAATCCAATCATCCATTGGCAACTGCTATTGTAAATTATTTCAATCCTGAGCCCTCACAGAAAAGATTGAATATCAGTGTTGAGCACTACTTAGGGCAGGGACTTCTGGCAACCTATGATGGTTTATCGTTCAAGATTGGAAAGCCTCAATTATTTCATCAAGTTGATAAGCACTGGTTAGAAAAAAAAGAAAAAGAGGAAGCTAATGGGAGGACTGTTGTTTTTGTTGCTCTCAATGAAACAGTTGTTGGATTCATTTCCATTCAAGACAGACCACAAGCTAATGCTGTGAAAGCTATTAATTATTTTAAAGCTGCTGGTGTCAAAACGCTGATGCTTACTGGTGATGCCAAGGCAGCGGGACAGGCTGTTGGGCGTGAATTAGGAATTGATGAGGTCGTCACTAATGTTTTGCCAGAACAAAAAGCAAAAATCATTGCGAAATATCAAAGTCAATATGGACTGACCGCCATGTTGGGAGACGGTGTTAATGATGCTCCTGCCCTAGCTACAGCGGATCTAGGAATTGCTATGGGAGATGGCACCGATATTGCTATAGAGACAGCTGATATCGTCCTGATGAAAAATGATTTAACCAAGTTAGTCAAAGCTCATAAACTATCCAAACGTTTACAAATTATTACCCGACAAAATATCAGCTTTGCTCTATTTGTGATTGTCCTTCTCATCAATCTTACTTTCTTTGGACATCTTTCAATGGTTACCAGTGTGACCCTACATGAAGGTTCTACCCTAATTGTTTTGTTTAACAGCCTCAGACTTTTACTAGATTACCATTAA","6.10","-6.31","67171","MPVTFFFLGLILFIAGLLPNFTPEVKNSLTILALLTAGYHVIWEGVEDTVEQSKKANCFVPNTHILMALAALGAVLLGETTEAALLIFIFAGAHFLEKYVEGCSQREITKLLELNPTEARRLTNTNEIEMISVDQLKIGDCVQVLNGGQVPADGKILEGYTSIDESTITGESIPYEKTVGDEVYASTINGSGTIIVEVSKDSSQTVFAKILQLVEASQGHFSPAAKRLNRFEPIYVSIVLLAFIGLLISGPLFWNWAWTKTISISLTFLVSASPCALAVSVIPATLAGISNLARQGVLFKGGCFLSDLTAIKMIAFDKTGTLTEGKPKVVTSQFLLSDISKEKFEAVLVAMESQSNHPLATAIVNYFNPEPSQKRLNISVEHYLGQGLLATYDGLSFKIGKPQLFHQVDKHWLEKKEKEEANGRTVVFVALNETVVGFISIQDRPQANAVKAINYFKAAGVKTLMLTGDAKAAGQAVGRELGIDEVVTNVLPEQKAKIIAKYQSQYGLTAMLGDGVNDAPALATADLGIAMGDGTDIAIETADIVLMKNDLTKLVKAHKLSKRLQIITRQNISFALFVIVLLINLTFFGHLSMVTSVTLHEGSTLIVLFNSLRLLLDYH","1928301","From GenBank (gi:584870): In Staphylococcus aureus, CadD, an electroneutral antiporter ejects one Cd2+ while accumulating two protons by an energy-dependent efflux mechanism. It catalyzes the reaction: ATP + H(2)O + CD(2+)(IN) = ADP + phosphate + CD(2+)(OUT). It is an integral membrane protein that belongs to the cation transport ATPases family (E1-E2 ATPases), subfamily IB and contains 2 heavy-metal-associated (HMA) domains.From GenBank (gi:115414): This protein is also similar to a slightly lesser degree to S. aureus CadA, another cadmium antiporter with the same function as CadD, but having only one heavy-metal-associated domain.Note: Check start codon.","cadmium-efflux ATPase, E1-E2 (heavy metal-transporting ATPase)","Membrane, Cytoplasm, Extracellular","Numerous strong matches in gapped BLAST to heavy metal-transporting ATPases and cadmium-transporting ATPases; residues 31-615 are 43% similar to cadmium-transporting ATPase of Bacillus halodurans (gi|15613307); residues 23-615 are 36% similar to metal-transporting ATPase of Streptococcus pyogenes (gi|15675345).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0385 (7e-91).","

InterPro
IPR000150
Family

Cof protein
PS01229	$\"[512-534]?$	COF_2

InterPro
IPR000695
Family

H+ transporting ATPase, proton pump
PR00120	$\"[484-500]T$ $\"[512-528]T$ $\"[543-568]T$	HATPASE

InterPro
IPR001757
Family

ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
PR00119	$\"[164-178]T$ $\"[315-329]T$ $\"[437-448]T$ $\"[459-469]T$ $\"[512-531]T$ $\"[535-547]T$	CATATPASE
PTHR11939	$\"[65-619]T$	ATPase_P
TIGR01494	$\"[85-330]T$ $\"[400-600]T$	ATPase_P-type
PS00154	$\"[317-323]?$	ATPASE_E1_E2

InterPro
IPR005834
Domain

Haloacid dehalogenase-like hydrolase
PF00702	$\"[311-535]T$	Hydrolase

InterPro
IPR006404
Family

Heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
TIGR01512	$\"[63-616]T$	ATPase-IB2_Cd

InterPro
IPR006416
Family

Heavy metal translocating P-type ATPase
TIGR01525	$\"[63-614]T$	ATPase-IB_hvy

InterPro
IPR008250
Domain

E1-E2 ATPase-associated region
PF00122	$\"[85-302]T$	E1-E2_ATPase

noIPR
unintegrated

unintegrated
G3DSA:2.70.150.10	$\"[104-195]T$	G3DSA:2.70.150.10
G3DSA:3.40.50.1000	$\"[432-556]T$	G3DSA:3.40.50.1000
PTHR11939:SF31	$\"[65-619]T$	PTHR11939:SF31
SSF56784	$\"[302-557]T$	SSF56784
SSF81653	$\"[115-214]T$	SSF81653
SSF81665	$\"[38-301]T$	SSF81665

","BeTs to 12 clades of COG2217COG name: Cation transport ATPasesFunctional Class: PThe phylogenetic pattern of COG2217 is AmT-YQvCEBRhUJ---lin-Number of proteins in this genome belonging to this COG is 3","***** IPB001757 (E1-E2 ATPases) with a combined E-value of 1.1e-21. IPB001757A 314-325 IPB001757B 503-532","Residues 245-330 are 55% similar to a (ATPASE HYDROLASE TRANSMEMBRANE ATP-BINDING) protein domain (PD000466) which is seen in Q59997_SYNY3.Residues 187-239 are 47% similar to a (ATPASE PROTEOME COMPLETE ATP-BINDING) protein domain (PD394319) which is seen in Q9KEV5_BACHD.Residues 85-177 are 51% similar to a (ATPASE HYDROLASE TRANSMEMBRANE ATP-BINDING) protein domain (PD000132) which is seen in Q9KEV5_BACHD.Residues 341-444 are 31% similar to a (ATPASE TRANSMEMBRANE PHOSPHORYLATION HYDROLASE) protein domain (PD037880) which is seen in Q9KEV5_BACHD.Residues 457-522 are 48% similar to a (ATPASE HYDROLASE TRANSMEMBRANE PHOSPHORYLATION) protein domain (PD000121) which is seen in O67432_AQUAE.Residues 531-615 are 54% similar to a (ATPASE HYDROLASE ATP-BINDING TRANSMEMBRANE) protein domain (PD274998) which is seen in O31688_BACSU.Residues 342-450 are 33% similar to a (PROTEOME COMPLETE YKV) protein domain (PD396849) which is seen in O31688_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 13:25:19 2002","Tue Jan 8 10:56:50 2002","Tue Oct 22 18:41:19 2002","Tue Jan 8 10:56:50 2002","Tue Jan 8 10:56:50 2002","Tue Jan 8 10:56:50 2002","no","Thu Oct 10 18:00:20 2002","SMu1867 is paralogously related (blast p-value < 1e-3) to SMu0386 ,a predicted copper-transporting ATPase; SMu0660, a predicted calcium-transporting ATPase and SMu1421, a predicted cation-transporting P-ATPase PacL.","Mon Apr 15 13:25:19 2002","Tue Jan 8 10:56:50 2002","pdb|1EUL|A Chain A, Crystal Structure Of Calcium Atpase With Tw... 84 4e-017","SMU.2057c","Wed Apr 24 10:39:06 2002","Residues 85 to 307 (E-value = 2.4e-57) place SMu1867 in the E1-E2_ATPase family which is described as E1-E2 ATPase (PF00122)Residues 311 to 535 (E-value = 5.4e-29) place SMu1867 in the Hydrolase family which is described as haloacid dehalogenase-like hydrolase (PF00702)","Tue Jan 8 10:56:50 2002","24380394","","","Nucifora,G., Chu,L., Misra,T.K. and Silver,S. Cadmium resistance from Staphylococcus aureus plasmid pI258 cadA gene results from a cadmium-efflux ATPase. Proc. Natl. Acad. Sci. U.S.A. 86 (10), 3544-3548 (1989) PubMed: 2524829.","Wed Apr 24 10:37:14 2002","Tue Jan 8 11:12:46 2002","1","","","SMU.2057c","" "SMu1868","1930297","1931091","795","GTGAAAAAAACGCAACAGTTATTAACAATTGGACAATTGGCTAAGTTTTCAGGTCTTCATGTCAAAGCATTACGTTATTATGAAAAAATCGGAATTTTAAACCCGACTGCTATAGATAAACAAAATGGTTATCGCTATTATTCTTATGCTCACATTCCTTATGTGAACATGATTAAAATTTGTGCTAATTATGGTCTGCCTTTAAAACAATTTACTCATTACATTTTAGATGATGGCAGCATTGATATGAATGCTATTTTAAAGGAAGCTCAGCTTAAAATTGAGGAAAAAGAAAGACAGCTGCAGTCTGATGAGCGCTATCTTCGCTTCTTTTCTGAGCAAATCAACTTCTCCCAAAAGCTTGATAAAACGACAAATTTGCATATTGAACAAGGAAATAAAGACTATTTTCTGCTGCCTTTTACAGGGGAAATGCTGTCAGCAAAATATTATGAAGCTGTCAGGTGTGCTCTGGCCGAGATTGAAAAATGTCAAATGACTTTTGATGACCGCGTTGGCTGTTATTTTAAGTATGATGATCAACAAGTAAACAGCTTTATTGCTATTAAAATCAAAGAATGTCAAGAAGATAAGACAAATTTTTTAAGTCTATGCCTCAATCATCGTCATATTCATGCTCAACACCTAACCAAAGACCGTATTCAACCAAAAATAAAAGAACTGCATCAAAAGGAGTCTATCAATGAATTTTTAATCTTAGAAACCTTTGAAAGTCCTTATCAATTATCACAACCACATTTAGAAATGCAATACGTTGTTGATAATACAGGGTAA","7.20","1.13","31070","MKKTQQLLTIGQLAKFSGLHVKALRYYEKIGILNPTAIDKQNGYRYYSYAHIPYVNMIKICANYGLPLKQFTHYILDDGSIDMNAILKEAQLKIEEKERQLQSDERYLRFFSEQINFSQKLDKTTNLHIEQGNKDYFLLPFTGEMLSAKYYEAVRCALAEIEKCQMTFDDRVGCYFKYDDQQVNSFIAIKIKECQEDKTNFLSLCLNHRHIHAQHLTKDRIQPKIKELHQKESINEFLILETFESPYQLSQPHLEMQYVVDNTG","1931103","From GenBank (gi:728974): In B. subtilits, a weakly similar transcriptional regulator activates transcription of the blt gene in response to structurally dissimilar drugs. It belongs to the MerR family of transcriptional regulators.","transcriptional regulator","Cytoplasm","Several very weak matches in gapped BLAST to transcriptional regulators; residues 5-106 are 31% similar to multidrug-efflux transporter regulator of Bacillus subtilis (gi16077613); residues 8-68 are 45% similar to transcriptional regulator, MerR family of Deinococcus radiodurans (gi15807435).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1655 (6e-08).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PF00376	$\"[9-47]T$	MerR
SM00422	$\"[8-78]T$	HTH_MERR
PS50937	$\"[7-77]T$	HTH_MERR_2
PS00552	$\"[11-33]?$	HTH_MERR_1

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[8-116]T$	no description

","BeTs to 6 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 1.7e-16. IPB000551A 10-31 IPB000551B 34-75","Residues 11-47 are 54% similar to a (TRANSCRIPTION DNA-BINDING REGULATION REGULATOR) protein domain (PD000861) which is seen in Q9K774_BACHD.Residues 9-68 are 45% similar to a (III PROTEOME TRANSCRIPTIONAL BETA) protein domain (PD327950) which is seen in Q9RRP0_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 13:27:05 2002","Fri Mar 16 14:31:50 2007","Fri Mar 16 14:28:25 2007","Mon Jan 7 14:43:41 2002","Mon Jan 7 14:43:41 2002","Mon Jan 7 14:43:41 2002","yes","Thu Oct 24 15:25:06 2002","SMu1868 is paralogously related (blast p-value < 1e-3) to SMu1630, SMu0477, SMu0663, SMu1918, and SMu0144,mostly MerR-related transcriptionalregulators.","Mon Apr 15 13:27:05 2002","Fri Mar 16 14:28:25 2007","pdb1EXIA Chain A, Crystal Structure Of Transcription Activato... 62 7e-011","SMU.2058","Mon Jan 7 14:43:41 2002","Residues 9 to 47 (E-value = 2.7e-12) place SMu1868 in the MerR family which is described as MerR family regulatory protein (PF00376)","Mon Jan 7 14:43:41 2002","24380395","","","Ahmed,M., Lyass,L., Markham,P.N., Taylor,S.S., Vazquez-Laslop,N. and Neyfakh,A.A. Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J. Bacteriol. 177 (14), 3904-3910 (1995) PubMed: 7608059.","","Mon Jan 7 14:43:41 2002","1","","","SMU.2058","" "SMu1869","1932301","1931276","1026","ATGTCGCTTAAATTTCAAAAATTATCAGGACTTGTTCTCTGTTTCTTAATTGCTCTGCCAGCTTGGTTTTTAGGACAAAGTTTTCCTCTTGTTGGGGCACCGGTTTTTGCTATCTTTTTAGGAATGTTGCTCGCTATTTTTTATAAAAATCGTGAGCATACAGAAGCTGGCATTGCTTTTACGTCTAAATATATTTTGCAATTTGCCGTTGTTTTGCTCGGTTTTGGCTTGAATTTGTCACAGGTTTTAACAGTCGGCAAAACATCCTTACCCATTATCGTAGCAACGATTAGTTCTTCCTTGCTTTTGGCTTTCCTATTACAAAAATGGTTCAAACTGGATGTCAATACAGCAACTTTGGTTGGAGTCGGTTCTTCCATTTGTGGCGGCTCCGCTATTGCAGCAACAGCACCTGTTATTCAAGCAGATGGTGATGAGATTGCCCAGTCCATTTCAGTGATTTTTCTTTTTAATATTTTAGCTGCTTTAATTTTTCCAACCTTAGGAGATATGATTGGCTTGTCCAACCATGGCTTTGCCCTTTTTGCAGGAACAGCAGTCAATGATACTTCATCCGTTACTGCAACAGCAGCAGCTTGGGATGGACTGCATCATTCGAACACATTGGATGGAGCAACCATTGTTAAATTGACACGAACATTGGCTATTATTCCTATTACCTTAGGTTTATCTTTTTATCAAGTTTATAAGACTAAAAAAGTAGGGAAAAATCAACAACATACAGTCAAATTAAAGAAGGTCTTTCCTATGTTTATTCTTTACTTTATTTTGGCTTCTATTATCACAACTATTTTAACAGCTTTAGGAGTCAATCCTATTTTCTTCACTCCTTTGAAAACTCTGTCTAAGTTTTGTATTGTCATGGCCATGGGAGCTATTGGCTTAAATACTAATATTGTTAAGCTGGTTAAAACCGGCGGTCAGGCTATTGTGCTTGGCGCTTCCTGCTGGATAGTTATCACCTTGGTTAGTCTTGGGATGCAACATCTCTTAGGCATTTGGTGA","10.30","12.23","36342","MSLKFQKLSGLVLCFLIALPAWFLGQSFPLVGAPVFAIFLGMLLAIFYKNREHTEAGIAFTSKYILQFAVVLLGFGLNLSQVLTVGKTSLPIIVATISSSLLLAFLLQKWFKLDVNTATLVGVGSSICGGSAIAATAPVIQADGDEIAQSISVIFLFNILAALIFPTLGDMIGLSNHGFALFAGTAVNDTSSVTATAAAWDGLHHSNTLDGATIVKLTRTLAIIPITLGLSFYQVYKTKKVGKNQQHTVKLKKVFPMFILYFILASIITTILTALGVNPIFFTPLKTLSKFCIVMAMGAIGLNTNIVKLVKTGGQAIVLGASCWIVITLVSLGMQHLLGIW","1931294","","conserved hypothetical protein; possible membrane protein","Membrane, Cytoplasm","Many matches in gapped BLAST to conserved hypothetical proteins and membrane proteins; residues 1-341 are 68% similar to conserved hypothetical protein of Streptococcus pyogenes (gi15675048); residues 1-341 are 61% similar to membrane protein of Streptococcus pneumoniae (gi15899980).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1125 (1e-123).","

InterPro
IPR004630
Family

Conserved hypothetical protein 698
PF03601	$\"[9-320]T$	Cons_hypoth698

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 33-327 are 29% similar to a (PROTEOME COMPLETE MEMBRANE PM1461) protein domain (PD024619) which is seen in YEIH_ECOLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 17:55:32 2002","Wed Sep 13 10:56:58 2006","Wed Sep 13 10:56:58 2006","Mon Jan 7 14:30:27 2002","","Mon Jan 7 14:30:27 2002","no","Thu Oct 10 17:55:32 2002","SMu1869 is paralogously related (blast p-value < 1e-3) to SMu0548, a predicted sodium-dependent transporter.","Mon Apr 15 13:29:52 2002","","No significant hits to the NCBI PDB database.","SMU.2059c","Mon Jan 7 15:09:33 2002","Residues 9 to 320 (E-value = 2.1e-129) place SMu1869 in the Cons_hypoth698 family which is described as Conserved hypothetical protein 698 (PF03601)","Mon Jan 7 14:30:27 2002","24380396","","","","","","1","","","SMU.2059c","381" "SMu1870","1932406","1933281","876","ATGCTAGATTATCGCGTTAAGACTTTTATTAAAGTTTGTGAAACCTTGAATTTTACCAAAGCAGCTCAGGACTTACACATTACACAACCAGCAGTTACCAAACACATTAAGGCTTTGGAAGCTGAGTACGCTTGTTCTTTATTTCTTTTTAAAGGCAAGCAATGTCAAATGACTGCCGAAGGGCAGAAACTTTTTTTGATGCTGACATCCATGACTAATGATATTAACCATTTTAAACAAAGAGTTCATGAAACAATAACTCAGCTGCACTTTGGTGCTACAATGACTATTGGAGAATACGTTCTGACAGAGTCCTTAGCTCAACTGATAACAAGTCATCCACGTTTAGAATTGAAAATGAGCATCGCTAACACTCAAAAATTACTGGGAGAAATTGACCGAGGAGAGATTGACTTTGCTGTTATTGAAGGCTTCTTTTCTCAAGAACAATACGATAGTTCCATTTATAAACATGAACCTTTTATTGCAGTGGCTTCTCCTGCTTGTCCCCTGAAAAATCAAAAGCTAGGCTTAACTGACTTACTAGCAGAACCCTTAATCATTCGTGAAGAAGGGTCTGGCACGCGCGAAGTTTTAGATACTATTTTGAAAGAAAAAAACTTGGCTAAGTCAGATTTTCAAAAGGTCAGTGAAATCAGTAATTTAAACACGATTAAACAACTCGTTAGTCGTAATTTAGGAATCTCCTTTTTCTATCGCAGTGTTGTTCAAAAGGAGCTGGAAGAAGGCAGTTTAATAGAATTAAAGTTGGAGGAGTTTCCCGTTTATCATGATTTCACCTTTGTTTGGAATAAAAATAGTTTTTTTGAGGAAGAATATAAGGAAGTTTTGGATTTGATTAGGACTTATGCCTAA","5.70","-6.24","33381","MLDYRVKTFIKVCETLNFTKAAQDLHITQPAVTKHIKALEAEYACSLFLFKGKQCQMTAEGQKLFLMLTSMTNDINHFKQRVHETITQLHFGATMTIGEYVLTESLAQLITSHPRLELKMSIANTQKLLGEIDRGEIDFAVIEGFFSQEQYDSSIYKHEPFIAVASPACPLKNQKLGLTDLLAEPLIIREEGSGTREVLDTILKEKNLAKSDFQKVSEISNLNTIKQLVSRNLGISFFYRSVVQKELEEGSLIELKLEEFPVYHDFTFVWNKNSFFEEEYKEVLDLIRTYA","1933293","From GenBank (gi:548674): This protein is similar (e-18) to the Acidithiobacillus ferrooxidans RUBISCO operon transcriptional regulator, RbcR. It is a trans-acting transcriptional regulator of RUBISCO genes. It belongs to the LysR family of transcriptionalregulators.","transcriptional regulator, LysR family (possible RUBISCO transcriptional regulator, RscR)","Cytoplasm","Many moderate matches in gapped BLAST to transcription regulators; residues 6-269 are 32% similar to transcription regulator of Bacillus subtilis (gi|2126978); residues 5-272 are 26% similar to probable transcription regulator of Pseudomonas aeruginosa (gi|11352198).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0691 (4e-12).","

InterPro
IPR000847
Domain

Bacterial regulatory protein, LysR
PR00039	$\"[18-29]T$ $\"[29-39]T$ $\"[39-50]T$	HTHLYSR
PF00126	$\"[5-62]T$	HTH_1
PS50931	$\"[1-58]T$	HTH_LYSR

InterPro
IPR005119
Domain

LysR, substrate-binding
PF03466	$\"[82-291]T$	LysR_substrate

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-87]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.10	$\"[162-248]T$	G3DSA:3.40.190.10
SSF46785	$\"[1-84]T$	SSF46785
SSF53850	$\"[83-291]T$	SSF53850

noIPR
unintegrated

unintegrated
PS51257	$\"[1-21]T$	PROKAR_LIPOPROTEIN

InterPro
IPR001015
Family

Ferrochelatase
PD002792	$\"[10-319]T$	Ferrochelatase
PTHR11108	$\"[1-319]T$	Ferrochelatase
PF00762	$\"[5-319]T$	Ferrochelatase
TIGR00109	$\"[1-319]T$	hemH
PS00534	$\"[188-206]T$	FERROCHELATASE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1400	$\"[2-211]T$	G3DSA:3.40.50.1400
SSF53800	$\"[3-319]T$	SSF53800

","BeTs to 9 clades of COG0276COG name: Protoheme ferro-lyase (ferrochelatase)Functional Class: HThe phylogenetic pattern of COG0276 is ----yq-cebrhuj----inxNumber of proteins in this genome belonging to this COG is 1","***** IPB001015 (Ferrochelatase) with a combined E-value of 1.2e-61. IPB001015A 7-17 IPB001015B 70-76 IPB001015C 111-143 IPB001015D 188-201 IPB001015E 203-222 IPB001015F 232-248 IPB001015G 257-291","Residues 106-317 are 24% similar to a (HEME BIOSYNTHESIS LYASE FERRO-LYASE) protein domain (PD129988) which is seen in HEMZ_MYCLE.Residues 8-285 are 53% similar to a (HEME BIOSYNTHESIS FERROCHELATASE LYASE) protein domain (PD002792) which is seen in HEMZ_PASMU.Residues 206-305 are 44% similar to a (HEME BIOSYNTHESIS LYASE FERRO-LYASE) protein domain (PD299049) which is seen in HEMZ_PSEFL.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 17:51:34 2002","Mon Jan 7 11:57:09 2002","Thu Oct 10 17:51:34 2002","Mon Jan 7 11:57:09 2002","Mon Jan 7 11:57:09 2002","Mon Jan 7 11:57:09 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1872 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Jan 7 12:01:00 2002","Mon Jan 7 11:57:09 2002","pdb|1C9E|A Chain A, Structure Of Ferrochelatase With Copper(Ii)... 71 2e-013pdb|1DOZ|A Chain A, Crystal Structure Of Ferrochelatase 71 2e-013pdb|1AK1| Ferrochelatase From Bacillus Subtilis >gi|7546509|p... 71 2e-013","SMU.2063c","Mon Jan 7 11:57:09 2002","Residues 5 to 319 (E-value = 6.5e-120) place SMu1872 in the Ferrochelatase family which is described as Ferrochelatase (PF00762)","Mon Jan 7 11:57:09 2002","","","","Miyamoto,K., Kanaya,S., Morikawa,K. and Inokuchi,H. Overproduction, purification, and characterization of ferrochelatase from Escherichia coli. J. Biochem. 115 (3), 545-551 (1994) PubMed: 8056770.Frustaci,J.M. and O'Brian,M.R. The Escherichia coli visA gene encodes ferrochelatase, the final enzyme of the heme biosynthetic pathway. J. Bacteriol. 175 (7), 2154-2156 (1993) PubMed: 8458858.","","Thu Oct 10 17:51:34 2002","1","","","SMU.2063c","" "SMu1873","1938042","1935244","2799","ATGGTATCAAGAGAAGAAAAAGACAACAAAGCAGTAAATGAAGGAACTCAAGATATGAGGCAGGAACCTTTGGAACATTTCAGTCGCAGTCGTGCACATCGTTCACAAGCGCGTCATCAGGAGACTGTTGCTTCTGAAAAAGAAGAGCAAAAGAATACAGAAAAGGCTCCTTTTAAGAATACCTTAGGATTTTTAGCCGCTTTCTGCCTGCCTATGTTAGTGATGGCAGTCGTTTTTGCTGTCATGAAGCTTTATCCTTTTGGTAAGGAAACTTTGATGAGCGGTGATTATACTTTACAATACATTCCCCTTTATCGTGCCTTAGGACATGCTTTTAGACATATGGATATTGGTGCTCTCTTTTGGTCTTGGCACAAAGGGGTTGGTGGTGTGATGCCATCTGTTTGGGGCTTCAACAGTCTCAGTCCCTTTAGTCTAGCTATTGGTTTGGCACCTGCTAAATATCTTAATTTATCAGTTTTTCTGGTAACCTTGCTGCGCCAAGGTTTTTCTGGTCTTAGCTTCTATTATTTCCTTCACAAACGTTATGAAGCCCATCGTCACCGTTTATTGGCTGTCTGTATAGCTGCTATCTATGGTTTGAGCGGTTTTCTTATTGTTAATCAGGTCAATCCTAATTTCTTAGATAATATTATTCTTTTACCACTTTTGCTGATTGGTGTGGAAAAAATTCTAGATGGCAAAGTCAGTATCAAGTATACCTTGGTTTTGGCTCTTATGTTTGTGGTTCAATTTTACACGGCTTATATGGCCTGTATCTTTGTTATTTTCTACAGTTTTTATTATATCCTAGCTCAAAAATCAGCTTTTCTTTTTAAAGCAAAGCAGTTGCTGCGTTTGCTAATCTATTCTCTTTTGGGAATAGGTTTGAGTGCGATTTGGCTTTTGCCGGTTTTTTATTCTCTCTTAGATACAAAGGCTGCAGGCGGAGAGGTTGATCCTTGGGCTTTTACGTTTCTTTATAATCCCATCAGACTTTTAATTAAGTTCTTTCCCGGTGCGGCCAGTGGTGAAGAATGGGGAGATTTTACTGCTCTGCCTAATTTTTATGTTGGTGTTCTTGGCTTTATTGGCTTGTTTAATTTCTTTTTCACTAAGAGAATCGCCTTACGTAAGAAAATCAGCGGTTTCTTATTATTGATCTTTCTTATTTTAGCTTTTTCGAATGCAGCTGCTATCCGTTTTTGGCATATGGGACAAATGCCGGTTGGTTTTTACTACCGTAATGCTTGGCTGTTGAGCCCTGTTTTCTTAATCTTAACTTATCAAGCTTTGCAAAAGGTCAAGTCTTGGAGTCGTCTGCAAATGATTGCGACTTTCGTCCTTGCTCTTTTAGCCAATGTTTATGTTTATTTTGCTGTTAAGGAAAAAACTTACACTTTGGTCACCGTTTGGCAGGAATTGGGCATGATCATTACTTTAATTTTACTCTTGTTCTTGATTTGGTTCCAACTGTCTAAGTCCTGGCAGCTTGCTTTTGTTATTTTAGTAAGCATGGTTGATATGGGGATCAATGCTAAAATAACGATTGACAGAAATTTATGGCATAGCCCAAGCTCTGTTTTGGCTGCTGAAAGTAAGCAGGAGGCGTTTTACAAAAACTTGAAGCTGCCTAAATCAGGCTTGGCACGTCTTGAAAAAAGCAGTGCCAATACTTGGAATGATTCTCTGACTTATAATTATTATGGTGTTAATCATTTTACATCTAGCGTTGAATATAAGAATTTAGAATTTTTAGGAAGACTTGGTCTGCCTTCTTCAACAGCTATTTCCATGTATGTTGGCGGTACGCCTTTAACAGATGCTTTGGTTAATTTACGTTATTATGTGGATAATGCTACTTGGACTTACTCTGCCAGAAAAGATTTAGCTAATTATTATCATCCTATTCAAACTCTGGGAAATGCTAAACTGTTAGAAAATACTTCTGTTTTTGGCTTGGGTTTTTCGGGTGATGGTGCTATGCTAAGGGAAAAATTAGATAAGGAAGATGTTGTTGCTAATCAAAATCAGATTTATCATGGTCTTTCGGACAATCTTGAAAATCTTCTTGATCCTTATCAAGCAGCTAATCTGTCTTTAGATAATGTTGCTTTGGCTGATGATGCTAATGGACAGCAAATTTATAAACGTCAGTCTTCAGACCGTCCGGGTACTATCCGTTTGACTTGGACACCACAGGATAATAATTCATATTATTTGTATTCTTCACAAATTCATTCGACAGATTTAAATCATCTTAAATTCACTTTGAATGGGCAAGCTTACACGGTTTTTGATCGTTACCGTAACCCACAGCTTTGGAGCCTTGCTTCCAACAGCAAAGACCAAGAACAAACCTTTGAAATCAGTTTAACAGATAATAGTTCTCTTAACTTAACAGGTTTGCAACTCTATCGCTTCAATGACGATAGTTTCACAAATTTCGTGAAGCAAGGTCATATTGCTAAATGGAATCCTGAAAAAGTAACTTCACTATCTCTTTCAGGAGAAGTAAAACAAGTTTCAGGTAAGAATTATTTATTTACTTCTATTCCTTATAATGCTGGCTGGCACGTAAAAGTAGATGGCAAAACGGTCAAAACGCAGGAAGTTTGGAATGCTATGTTAGCCTTTAAGCTGCCGTCAGGTAAACATCAGATAAAACTTTATTATATCCCACAAGGACTTATCTATGGCAGCCTTATTACCTTACTTTCTTTAATATTTGTCATTAGTATTTTAAGAAAAAGCCGTCAATTAAGAAAAAAGCAGGAAGAAGAAAGAGAACCTGTTTAA","10.20","26.47","106114","MVSREEKDNKAVNEGTQDMRQEPLEHFSRSRAHRSQARHQETVASEKEEQKNTEKAPFKNTLGFLAAFCLPMLVMAVVFAVMKLYPFGKETLMSGDYTLQYIPLYRALGHAFRHMDIGALFWSWHKGVGGVMPSVWGFNSLSPFSLAIGLAPAKYLNLSVFLVTLLRQGFSGLSFYYFLHKRYEAHRHRLLAVCIAAIYGLSGFLIVNQVNPNFLDNIILLPLLLIGVEKILDGKVSIKYTLVLALMFVVQFYTAYMACIFVIFYSFYYILAQKSAFLFKAKQLLRLLIYSLLGIGLSAIWLLPVFYSLLDTKAAGGEVDPWAFTFLYNPIRLLIKFFPGAASGEEWGDFTALPNFYVGVLGFIGLFNFFFTKRIALRKKISGFLLLIFLILAFSNAAAIRFWHMGQMPVGFYYRNAWLLSPVFLILTYQALQKVKSWSRLQMIATFVLALLANVYVYFAVKEKTYTLVTVWQELGMIITLILLLFLIWFQLSKSWQLAFVILVSMVDMGINAKITIDRNLWHSPSSVLAAESKQEAFYKNLKLPKSGLARLEKSSANTWNDSLTYNYYGVNHFTSSVEYKNLEFLGRLGLPSSTAISMYVGGTPLTDALVNLRYYVDNATWTYSARKDLANYYHPIQTLGNAKLLENTSVFGLGFSGDGAMLREKLDKEDVVANQNQIYHGLSDNLENLLDPYQAANLSLDNVALADDANGQQIYKRQSSDRPGTIRLTWTPQDNNSYYLYSSQIHSTDLNHLKFTLNGQAYTVFDRYRNPQLWSLASNSKDQEQTFEISLTDNSSLNLTGLQLYRFNDDSFTNFVKQGHIAKWNPEKVTSLSLSGEVKQVSGKNYLFTSIPYNAGWHVKVDGKTVKTQEVWNAMLAFKLPSGKHQIKLYYIPQGLIYGSLITLLSLIFVISILRKSRQLRKKQEEEREPV","1935262","","hypothetical protein","Membrane, Cytoplasm","No matches in gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2172 (1e-30).","

noIPR
unintegrated

unintegrated
tmhmm	$\"[62-82]?$ $\"[101-123]?$ $\"[133-153]?$ $\"[159-179]?$ $\"[189-207]?$ $\"[252-272]?$ $\"[287-307]?$ $\"[352-372]?$ $\"[382-402]?$ $\"[412-432]?$ $\"[441-461]?$ $\"[475-493]?$ $\"[498-516]?$ $\"[897-915]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 65-260 are 27% similar to a (MEMBRANE INTEGRAL) protein domain (PD327244) which is seen in Q9EWD3_STRCO.Residues 159-912 are 21% similar to a (PROTEOME COMPLETE YFHO YIEH) protein domain (PD148064) which is seen in Q9CHA3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:25:44 2002","Mon Jan 7 11:45:12 2002","Mon Jan 7 11:45:12 2002","Mon Jan 7 11:45:12 2002","","Mon Jan 7 11:45:12 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1873 is paralogously related (blast p-value < 1e-3) to SMu1875,a predicted conserved hypothetical protein (possible integral membrane protein/ABC transporter) and SMu1960,a possible permease, ABC transporter protein.","Mon Apr 15 13:36:27 2002","","No significant hits to the NCBI PDB database.","SMU.2064c","Mon Jan 7 11:45:12 2002","No significant hits to the Pfam 11.0 database","Mon Jan 7 11:45:12 2002","24380400","","","","","","1","","","SMU.2064c","" "SMu1874","1939191","1938175","1017","ATGACGAAAATTCTAGTAACAGGGGGCGCTGGTTATCTGGGTTCTCATACTTGTGTTGAATTATTAAACCAAGATTATCGGCTTGTTGTTGTGGATAATTTGCTGCATTCTAGTTTCAAAAGTTTAACAGCCATTAAAGAGATTACTGGCAAAGACTTTACTTTTTATCAGGCAGATATTAGAGATAAGAAAAGTCTTGAAGCCATTTTTGAAAAGGAAGCCATTACTGCGGTCATCCATTTCGCAGGACTTAAAATTGTGAATGAATCTACTTCTATTCCGCTTGATTATTATGCTAACAATTTTTCGGGAACCATTACACTCTTACAAGTTATGCAGCAGTTTTCCTGTAAAAATTTTATCTTTTCATCCTCAGCCAGCGTTTATGGAAATAAAGCACCTGCTCCAGTTTCAGAAGAGGCGCCACGTTCGGTGATGACCCCTTATGGTCGTACAAAGATGATGATTGAAGATGTGTTAATGGATGTGTCTGTTTCAGATAGTGCTTGGAATATTGTCATTTTGCGCTATTTTAACCCCATTGGTGCTCACAGTTCAGGTGAGTTAGGCGAAGATCCTCAAGGTTTGCCAACTAATCTTTTACCTTATATAAGCCAAGTTGCTCTTGGAAAATTAGATAGGGTGCGGGTTTTTGGTGGTGATTATGATACCAAAGATGGGACTGGTATTCGTGATTATATTCATGTTGTCGATCTTGCTAGAGGCCATGTTGCAGCTTTACAAAAACTAGTTGCTGGTTCGGGTCTTTCAATTTATAATCTAGGAACTGGAAAAGGAACTTCTGTTTTAGAGCTTATTCAAGAAATGGGAGAAATTGTTGGACATCCCATTCCTTATAAAATCGTTGGCAGGCGTGCAGGAGATATTGCTGTTTCTTATGCTGATGTCTCTAAAGCTGAGAAAGAGCTGAATTGGCATGCCCGATATGATTTAAAACGGATGTGCCAAGACTCTTGGCGCTGGCAAAAAAAGTACCCTAATGGATTTAGAGAGTAA","7.20","0.79","37390","MTKILVTGGAGYLGSHTCVELLNQDYRLVVVDNLLHSSFKSLTAIKEITGKDFTFYQADIRDKKSLEAIFEKEAITAVIHFAGLKIVNESTSIPLDYYANNFSGTITLLQVMQQFSCKNFIFSSSASVYGNKAPAPVSEEAPRSVMTPYGRTKMMIEDVLMDVSVSDSAWNIVILRYFNPIGAHSSGELGEDPQGLPTNLLPYISQVALGKLDRVRVFGGDYDTKDGTGIRDYIHVVDLARGHVAALQKLVAGSGLSIYNLGTGKGTSVLELIQEMGEIVGHPIPYKIVGRRAGDIAVSYADVSKAEKELNWHARYDLKRMCQDSWRWQKKYPNGFRE","1938193","For other 'gal' genes see SMu0807 (galR); SMu0808 (galK); SMu0809 (galT); SMu0810 (galE) and SMu0289 (galU). From GenBank (gi:1730193): This enzyme catalyzes the reaction UDP-glucose = UDP-galactose, requiring a cofactor, NAD. This is involved in the galactose metabolism pathway. It is a homodimer that belongs to the sugar epimerase family.From GenBank (gi:2494659): In H.sapiens, this protein catalyzes two distinct but analgous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.","UDP-glucose 4-epimerase","Cytoplasm","Numerous strong matches in gapped BLAST to UDP-glucose 4-epimerase; e.g. residues 3-338 are 61% similar to UDP-glucose 4-epimerase of Streptococcus pneumoniae (gi|15903503); residues 4-337 are 54% similar to UDP-glucose 4-epimerase of Bacillus subtilis (gi|1730193).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1923 (1e-65).","

InterPro
IPR001509
Family

NAD-dependent epimerase/dehydratase
PF01370	$\"[4-262]T$	Epimerase

InterPro
IPR005886
Family

UDP-glucose 4-epimerase
PTHR10366:SF39	$\"[6-337]T$	GalE
TIGR01179	$\"[3-336]T$	galE

InterPro
IPR008089
Family

Nucleotide sugar epimerase
PR01713	$\"[231-246]T$ $\"[256-271]T$ $\"[295-312]T$	NUCEPIMERASE

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[3-212]T$	G3DSA:3.40.50.720
PTHR10366	$\"[6-337]T$	PTHR10366
SSF51735	$\"[3-338]T$	SSF51735

","BeTs to 8 clades of COG1087COG name: UDP-glucose 4-epimeraseFunctional Class: MThe phylogenetic pattern of COG1087 is --t-yq-Ceb-hujgp-----Number of proteins in this genome belonging to this COG is 2","***** IPB001509 (NAD dependent epimerase/dehydratase family) with a combined E-value of 2.3e-28. IPB001509A 4-25 IPB001509B 76-110 IPB001509D 231-238 IPB001509E 303-313***** IPB002225 (3-Beta hydroxysteroid dehydrogenase/isomerase family) with a combined E-value of 5e-10. IPB002225A 1-31 IPB002225B 123-177 IPB002225C 227-269 IPB002225D 292-336","Residues 4-329 are 55% similar to a (COMPLETE PROTEOME 4-EPIMERASE REDUCTASE UDP-GLUCOSE NAD) protein domain (PD000038) which is seen in GALE_BACSU.Residues 3-115 are 29% similar to a (SULFOLIPID BIOSYNTHESIS PROTEOME COMPLETE) protein domain (PD322104) which is seen in O48917_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 17:50:15 2002","Sun Jan 6 16:15:52 2002","Thu Oct 10 17:50:15 2002","Tue Apr 2 10:40:10 2002","Sun Jan 6 16:13:14 2002","Sun Jan 6 16:13:14 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1874 is paralogously related (blast p-value < 1e-3) to SMu0810, and SMu0346 both predicted UDP-glucose 4-epimerases; SMu1327,a predicted dTDP-glucose-4,6-dehydratase.","Mon Apr 15 13:38:33 2002","Sun Jan 6 16:13:14 2002","pdb|1EK5|A Chain A, Structure Of Human Udp-Galactose 4-Epimeras... 386 2e-108pdb|1UDC| Structure Of Udp-Galactose-4-Epimerase Complexed Wi... 363 1e-101pdb|1UDB| Structure Of Udp-Galactose-4-Epimerase Complexed W... 363 2e-101","SMU.2065c","","Residues 3 to 330 (E-value = 9.2e-07) place SMu1874 in the 3Beta_HSD family which is described as 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073)Residues 4 to 333 (E-value = 5.5e-136) place SMu1874 in the Epimerase family which is described as NAD dependent epimerase/dehydratase family (PF01370)","Sun Jan 6 16:13:14 2002","","","","Daude,N., Gallaher,T.K., Zeschnigk,M., Starzinski-Powitz,A., Petry,K.G., Haworth,I.S. and Reichardt,J.K. Molecular cloning, characterization, and mapping of a full-length cDNA encoding human UDP-galactose 4'-epimerase. Biochem. Mol. Med. 56 (1), 1-7 (1995) PubMed: 8593531.Quimby,B.B., Alano,A., Almashanu,S., DeSandro,A.M., Cowan,T.M. and Fridovich-Keil,J.L. Characterization of two mutations associated with epimerase-deficiency galactosemia, by use of a yeast expression system for human UDP-galactose-4-epimerase. Am. J. Hum. Genet. 61 (3), 590-598 (1997) PubMed: 9326324.","Mon Apr 15 13:38:33 2002","Thu Oct 10 17:50:15 2002","1","","","SMU.2065c","" "SMu1875","1942150","1939226","2925","ATGAGACATTCAAGAAAACAAGAAAGCCAAAGATCATCTTTTAAGAAAGCTGGGAAATTTAAGGTTCTTCTAGCAAGTACCTTGCTTCCAATGATGATTATGTTGGTTGTCTGGTATTTTATGGATACGTTTCCTTTTGGAAGAAATACTTTAATGGCAGTTGACTTTGGACAGCAGTATATCGGTCTTTATGGCTTTTTGAAGGCAACGGTTTTAACGGGTGATTGGTCAGGACTCTTTTATTCTTTTTCTAAGTCTATTGGCGGTGCTATGATTGGGATTTGGGGCTTCAATTTAATTAGTCCTTTTAATCTTTTTTATATTTTATTTCCTTTGACACAGTTTAAATGGGCAGTCTTTTTAACCATCTGGTTACGCTATGGAGCGATGGGCTTGAGTTTTGCTTATCTACTTATAAAACGTTACAAGGCGCTCTCTTATAATCCTTGGCTAGTTCCTCTTATGGCAACGGCCTATGCTCTTTCAGGTATGATTGTCTCTTATCAGATGAATCCTATCTTTTATGATGCGATGATCATGCTTCCTTTAGTTATTATTAGTCTTGAAGAGTTGATAGATGGTAGGAAACCGTTTAAATACATTATAGTGTTGGCTCTGACCATGCTTTTGCATTTTTATATGGGCTACATGATTTGTTTGTTCGTTGCCCTTTATACTTGTTATTATGCAGCACCGAAGTTGGCAGAAATCGGTGATTGGAAGATCAAAATAACTGCTTTCTTTAAACCTGTTTTACGTGTGATTTGCTATTCTATTTTGGCAATTACTTCAGTGTTCTTCCTGCTCTATCCTATCTTTTTAAATCTGTTACGCAGTAAAGGTGCTTACGATAGTCCTTTAACTTTTAGCTTTGCTCTCCAAATTAATCCTTTTGATATCTTATCAAAATTGATGATAGGTGGTTTTGACAATGAATCCTCTTGGTCAGCGGGGCCCAATTTACCTAATATTTATGTTGGGGCGCTTGCTTTGGTCGGCTTTTTCCTTTATTTTGTTCAGGCTAAAGCGCACAAATATAGCAAGGTTGTTGCTGCTTTTATTAGTCTTCTTTTCTTTGTTTCTATTGTTAATGAATTTGCTAATAAAATTTGGCATATGGGACAAAATCCAGCAGGTTTCTTTTATCGTTTCTCATGGATTTTATCTTTCTTTATGGTTCTTTTGGCTTACCAAGCTCTTAGAGAAAGGAAGTATCTGGGCTGGAAAGGCCTTATAGTAGGGATTATCTTGAGCTTTGCTTCGGCTTATTATGTTATCAGTCATGATTATACCTATATCGCGAAAAAACAACCTAAGATAGTGACAGATTTTGTGACTTCACATGAAGCTTTCATACTTCTTTTAGTCTTTGTTTTTTTCGCTGGTCTCGCTGTTTATACTTGGAAGCGGCTTGACCAATACAAAGAAGCTCGTTTGTGTGCGATTGCTGCTAGTTTATTAGCTATTCCAGTCTCGCTTTATTTGTTAAATAAGGGTCTCTTATTGACACAAGTTTGCCTTACTCTCTTAACTTGGCTTTTTGTTTTGATTTATCTGGCTCTTCGTCCTAAAAGCAAGCTTGTCTGGTCTCTTCTAGCCCTTGTTACGGTGCTTGAGTTGGGCTACAATGCCTACCTTTCTCAAGTGACTCTAGGCTATGCTGATGCTTATAAATTTACGGATGTCACTAAGAGTATGAAAGAATTATCAGATGTCATCAAGAAGAAAAATAAGGCAGGATTTTACCGTGTAGGCTCTAGTTTTCTCTATTCTAAAAACGATCCTTTCTTGGTTTCCTATCCCGGTTTAAGTACCTTTAGCTCCAATATGGAAAAATCAACTATTAATCTGTTTAACTCGATGGGAGATGTTGGTGGTAATGCAGCAACCTTTTATGCCAACGGAACGGCTTTAACAGATGCTCTTTACAGCGTTCGTTACTATATTGATCGTAAAGATTACAGTGCAACGGACATTGAAAAACACCCTAACTGGCAGTTCTTCAATCGAAATGCGACACGTTCAGATCTTAAAGAGTATTACAAACCTATTTATGAGAATAAACGCTTTATCATTTATGAAAATCCTGATGTCCTCTCACCAGCCTTTGGAACAAATACCTTGACACATAATATTAAGTTTGGGATTAATAATCCTGTTTCTAATCAAAATATTATTCTCTCTTCAATGTCTGGCAAGAAGCAAAAGTATTTTGAATATATCGGTATTCCTAAAATTGAGTTGATTAATATGCAGGAAGTTAATGAAAATGGGCACCGTATTTTCAAACGAATTGATAAAAAACAAGCTGGTACGATTAGGATTACCTTTACACCGCAAACGGATGATACTTATTATTTCCAAGCTCCTTATAGTTTACGCAAATCAATGGGAAATGTTTCCATTATGCTCAATAATCAATGGTATCATTACTCACAAAGCTATGATCAAGTACAACTTTGGAATTTAACCAGTAAGACACCAAATCAAGAGATGGTTTTACAGCTGCAAACTTCGCAAGATGATCAGCTTGACTTGACTAACATGGCCCTTGTCAGAGCTAATCAGACAGCTATTAAAAAAGTTATCGATGACCGCTTAAAACAAGATATGACAGTGACTAAGTGGACAAATACCTTAATTAAAGGACATGTTCAAATTACAGATAAAAGCAATGTCATGATGACCAGTATTCCTTATAATCCGGGTTGGACAGTGAAAGTAGACGGTAAAAAAGTCAAGACTGATGAGGCTTGGGGAAGTTTATTATCCTTTCCAATTACAAGTGGCAAACATCGTATTGAAATGTCCTTTATGCCTCAAGGTTTTGTTGTGGGAATTGCTGTTTCAGTGATTTCTGTTGCCCTTACTATTTTGTTAAAGTGGCAGGATTCTAGATCAGAAAAAAGAAGTTCTATTTCTTAA","10.40","40.67","111402","MRHSRKQESQRSSFKKAGKFKVLLASTLLPMMIMLVVWYFMDTFPFGRNTLMAVDFGQQYIGLYGFLKATVLTGDWSGLFYSFSKSIGGAMIGIWGFNLISPFNLFYILFPLTQFKWAVFLTIWLRYGAMGLSFAYLLIKRYKALSYNPWLVPLMATAYALSGMIVSYQMNPIFYDAMIMLPLVIISLEELIDGRKPFKYIIVLALTMLLHFYMGYMICLFVALYTCYYAAPKLAEIGDWKIKITAFFKPVLRVICYSILAITSVFFLLYPIFLNLLRSKGAYDSPLTFSFALQINPFDILSKLMIGGFDNESSWSAGPNLPNIYVGALALVGFFLYFVQAKAHKYSKVVAAFISLLFFVSIVNEFANKIWHMGQNPAGFFYRFSWILSFFMVLLAYQALRERKYLGWKGLIVGIILSFASAYYVISHDYTYIAKKQPKIVTDFVTSHEAFILLLVFVFFAGLAVYTWKRLDQYKEARLCAIAASLLAIPVSLYLLNKGLLLTQVCLTLLTWLFVLIYLALRPKSKLVWSLLALVTVLELGYNAYLSQVTLGYADAYKFTDVTKSMKELSDVIKKKNKAGFYRVGSSFLYSKNDPFLVSYPGLSTFSSNMEKSTINLFNSMGDVGGNAATFYANGTALTDALYSVRYYIDRKDYSATDIEKHPNWQFFNRNATRSDLKEYYKPIYENKRFIIYENPDVLSPAFGTNTLTHNIKFGINNPVSNQNIILSSMSGKKQKYFEYIGIPKIELINMQEVNENGHRIFKRIDKKQAGTIRITFTPQTDDTYYFQAPYSLRKSMGNVSIMLNNQWYHYSQSYDQVQLWNLTSKTPNQEMVLQLQTSQDDQLDLTNMALVRANQTAIKKVIDDRLKQDMTVTKWTNTLIKGHVQITDKSNVMMTSIPYNPGWTVKVDGKKVKTDEAWGSLLSFPITSGKHRIEMSFMPQGFVVGIAVSVISVALTILLKWQDSRSEKRSSIS","1939244","","conserved hypothetical protein (possible integral membrane protein, ABC transporter)","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins and integral membrane proteins; e.g. residues 20-940 are 21% similar to ABC transporter, permease protein of Streptococcus pneumoniae (gi|15902035); residues 24-433 are 26% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675943).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2172 (1e-42).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-43]?$	signal-peptide
tmhmm	$\"[21-41]?$ $\"[60-80]?$ $\"[90-110]?$ $\"[120-140]?$ $\"[150-170]?$ $\"[212-232]?$ $\"[253-273]?$ $\"[321-339]?$ $\"[349-367]?$ $\"[381-400]?$ $\"[405-425]?$ $\"[444-464]?$ $\"[479-497]?$ $\"[501-521]?$ $\"[526-546]?$ $\"[942-960]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 43-432 are 25% similar to a (MEMBRANE INTEGRAL) protein domain (PD327244) which is seen in Q9EWD3_STRCO.Residues 73-437 are 26% similar to a (PROTEOME COMPLETE YFHO YIEH) protein domain (PD148064) which is seen in Q9CHA3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:25:07 2002","Fri Jan 3 15:56:10 2003","Fri Jan 3 15:56:10 2003","Sun Jan 6 16:08:26 2002","","Sun Jan 6 16:08:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1875 is paralogously related (blast p-value < 1e-3) to SMu1873 , a predicted hypothetical protein and SMu1960,a possible permease, ABC transporter protein.","Mon Apr 15 13:40:06 2002","","No significant hits to the NCBI PDB database.","SMU.2066c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 16:08:26 2002","24380402","","","","","","1","","","SMU.2066c","" "SMu1876","1943106","1942147","960","ATGAAACTGTCAATCGTCGTCGCTTTTTATAATGAAGAAAAAATGATTGAGAAGACCCACAGTGAAATTTCCAAACAGTTGCAGTTAATGCAGCCAGATACTATTGATGAGTATGAGTTGGTTTATATCAATGATGGTAGTAAAGATAAAACGTTAAGTTTAATGAAACAAATGGCTCAAAACGATCATCATGTACGGTTCATCAGTTTTAGTCGTAACTTTGGTCGTGAAGGAGCTATTTTATCAGGACTAAAGTATGCAACTGGTGATGCTGTTATGTTGATGGATGGCGATTTGCAGCACCCTCCTGCTCTCATTCCAAGCTTTGTTACAGCTTTTAAGGAAGGTTATGATGTTGTCAGCGGTCAGCGTGACCGTAAGGGAGAACCTAAACAAAGCACTTTTTTTGCAAGGTTGTTTTACCGTTTTGCTAATCATTTGATGGATGTGCAGTTAACAGATGGCATTTCTGAGTTCAAACTTTTTAGCCGTAAGGCGGTTGATACTATTTTAGCCTTACCTGAGTATAATCGTTTTTCTAAAGGAATTTTTTCATGGATTGGTTTCAAAGAAAAGATTATCCCTTATCAAAATCAAGTTCGTGAAGCAGGAGAAAGTAAATTTGGTTTTAGGCGTTCCATGAATTATGCTTTTCAAGGAATCATTTCTTTCAATGATAAACCTTTACGTATCTGTATTCAGTTTGGGCTAGCCTGCGTTGGCTTTGCTCTCTTATATCTTTTAGTGATGTTTATTGCTTATTTTGTGAAGCCAGAAATTTTAGTCAGCGGTTATTTTACAACTTTAGCAGCTATTATTCTTTTTAGTGGTGTACAGTTGATTTCCATAGGTGTTCTGGGTGAATATATTGGGAAAATTTATTATGAAGTGAAACGGCGGCCGCATTATATTGTAGATGAAACAAATATTAAGAAAGCGAAAGAGGATTTAGTGGGATGA","9.40","5.36","36478","MKLSIVVAFYNEEKMIEKTHSEISKQLQLMQPDTIDEYELVYINDGSKDKTLSLMKQMAQNDHHVRFISFSRNFGREGAILSGLKYATGDAVMLMDGDLQHPPALIPSFVTAFKEGYDVVSGQRDRKGEPKQSTFFARLFYRFANHLMDVQLTDGISEFKLFSRKAVDTILALPEYNRFSKGIFSWIGFKEKIIPYQNQVREAGESKFGFRRSMNYAFQGIISFNDKPLRICIQFGLACVGFALLYLLVMFIAYFVKPEILVSGYFTTLAAIILFSGVQLISIGVLGEYIGKIYYEVKRRPHYIVDETNIKKAKEDLVG","1942165","","stress response protein (glycosyltransferase) (sugar transferase)","Membrane, Cytoplasm","Many matches in gapped BLAST to glycosyltransferase; e.g. residues 2-309 are 47% similar to probable sugar transferase of Streptomyces coelicolor (gi|7481439); residues 3-310 are 44% similar to stress response protein of Bacillus subtilis (gi|2498262).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1479 (2e-68).","

InterPro
IPR001173
Domain

Glycosyl transferase, family 2
PF00535	$\"[4-171]T$	Glycos_transf_2

noIPR
unintegrated

unintegrated
G3DSA:3.90.550.10	$\"[1-148]T$	G3DSA:3.90.550.10
PTHR10859	$\"[10-307]T$	PTHR10859
SSF53448	$\"[2-180]T$	SSF53448

","BeTs to 15 clades of COG0463COG name: Glycosyltransferases involved in cell wall biogenesisFunctional Class: MThe phylogenetic pattern of COG0463 is AMTKYQVCEBRHujGPo---XNumber of proteins in this genome belonging to this COG is 5","No significant hits to the Blocks database.","Residues 226-312 are 38% similar to a (TRANSFERASE PROTEOME COMPLETE GLYCOSIL) protein domain (PD392195) which is seen in Q9CJ93_LACLA.Residues 81-128 are 50% similar to a (TRANSFERASE PROTEOME COMPLETE SYNTHASE) protein domain (PD395383) which is seen in CSBB_BACSU.Residues 242-300 are 51% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD005262) which is seen in CSBB_BACSU.Residues 3-85 are 42% similar to a (TRANSFERASE COMPLETE PROTEOME GLYCOSYLTRANSFERASE) protein domain (PD000196) which is seen in O86666_STRCO.Residues 140-225 are 56% similar to a (TRANSFERASE GLYCOSYLTRANSFERASE) protein domain (PD360542) which is seen in O86666_STRCO.Residues 3-124 are 40% similar to a (PROTEOME COMPLETE TRANSFERASE) protein domain (PD319470) which is seen in Q9CJ93_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 17:47:54 2002","Sun Jan 6 15:59:48 2002","Mon Oct 21 09:57:23 2002","Mon Apr 15 13:51:08 2002","","Sun Jan 6 15:59:48 2002","yes","Mon Oct 21 09:57:23 2002","SMu1876 is paralogously related (blast p-value < 1e-3) to SMu0757 ,a predicted glycosil transferase; SMu0750,a predicted rhamnosyltransferase; SMu0758,a predicted conserved hypothetical protein; possible glycosyltransferase and SMu1308,a predicted conserved hypothetical protein; possible glycosyl transferase.","Mon Apr 15 13:51:08 2002","","No significant hits to the NCBI PDB database.","SMU.2067c","","Residues 4 to 171 (E-value = 1.7e-34) place SMu1876 in the Glycos_transf_2 family which is described as Glycosyl transferase (PF00535)","Sun Jan 6 15:59:48 2002","","","","","","","1","","","SMU.2067c","" "SMu1877","1943713","1944507","795","ATGTCTCAACATTTATTTACTGCCTTTATACTTACTGCTCTTGCTGGACTCTCGACCGGAATTGGTAGTTTAATTGCTTTTGTCACCAAACATACGAATAAAACTTTTTTATCTGTTAGTTTGGGGTTTTCCGCCGGTGTCATGATTTACGTTTCTATGATTGAGATTTTTCCAACAGCTCAAACCATTTTGACTAAAGCCATGGATAAAAAAAGTGGCTCTTGGTTAACTGTTCTAGCTTTTTTTGGAGGCATTCTTTTAATTGCTATTATTGATAAATTGATTCCATCTGAAGAGAATCCCCACGAGATTAAAACTATTGAAGAAGAAGACCAAAAGCCAACTAAACTAATGCGTATGGGGCTTATGACAGCCATTGCTATTGGGATTCATAATTTCCCAGAAGGACTGGCGACTTTCATTTCTGGTTTACAAGATGCCAGTATTGCTATTCCAATTGTCATCGCCATTGCTATTCATAATATTCCTGAAGGAATTGCCGTATCCGTTCCGATTTATCAGGCAACAGGTTCTAAGAAAAAAGCCTTTACTTATTCTTTTCTATCTGGTCTAGCTGAACCTTTAGGAGCCATTATTGGCTGGTTTCTCCTTATGCCTATTATGAATAATATTGTCTATGGGGCTATCTTTTCTGCTGTTGCTGGTATTATGGTCTTTATTTCTCTAGACGAGTTACTGCCAGCAGCAGAAGAGTATGGTAAACATCACCTTGCAATCTATGGAGTTATTTCTGGTATGCTTATCATGGCTGTTAGTCTCTTACTTTTTATTTAA","6.40","-2.32","28303","MSQHLFTAFILTALAGLSTGIGSLIAFVTKHTNKTFLSVSLGFSAGVMIYVSMIEIFPTAQTILTKAMDKKSGSWLTVLAFFGGILLIAIIDKLIPSEENPHEIKTIEEEDQKPTKLMRMGLMTAIAIGIHNFPEGLATFISGLQDASIAIPIVIAIAIHNIPEGIAVSVPIYQATGSKKKAFTYSFLSGLAEPLGAIIGWFLLMPIMNNIVYGAIFSAVAGIMVFISLDELLPAAEEYGKHHLAIYGVISGMLIMAVSLLLFI","1944519","","conserved hypothetical protein (probable integral membrane protein)","Membrane, Cytoplasm","Several matches in gapped BLAST to probable integral membrane proteins and conserved hypothetical proteins; e.g. residues 3-262 are 48% similar to probable integral membrane protein of Campylobacter jejuni (gi|15791634); residues 4-263 are 41% similar to conserved hypothetical protein of Neisseria meningitidis (gi|11352991).SMu1877 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003689
Family

Zinc/iron permease
PF02535	$\"[9-260]T$	Zip

noIPR
unintegrated

unintegrated
PTHR11065	$\"[65-264]T$	PTHR11065
SSF103473	$\"[2-113]T$	SSF103473

","BeTs to 7 clades of COG0428COG name: Predicted divalent heavy-metal cations transporterFunctional Class: PThe phylogenetic pattern of COG0428 is -mtkYqv-e-r-----o----Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 126-258 are 47% similar to a (COMPLETE PROTEOME TRANSMEMBRANE GUFA) protein domain (PD004603) which is seen in Q9PIN2_CAMJE.Residues 4-122 are 34% similar to a (PROTEOME COMPLETE NMB0175 MEMBRANE) protein domain (PD332128) which is seen in Q9JX23_NEIMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:24:14 2002","Sun Jan 6 15:56:00 2002","Sun Jan 6 15:56:00 2002","Tue Oct 8 14:24:14 2002","","Sun Jan 6 15:56:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1877 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:24:14 2002","","No significant hits to the NCBI PDB database.","SMU.2069","","Residues 7 to 260 (E-value = 3e-35) place SMu1877 in the Zip family which is described as ZIP Zinc transporter (PF02535)","Sun Jan 6 15:56:00 2002","24380404","","","","","","1","","","SMU.2069","" "SMu1878","1944534","1945262","729","ATGAAATTTTTAATTCCCACTGCTAAAGAAATAAAAGAGGATAACAAGCCTTATCCCCAGCACTTATCTCAGAAAAGTCAAATTCTTGTTAATCATATGAACGCCTTATCTATTGAAGAGCTCGAAAAGAGCTACAAGGTCAGTCCGCAAATAGCTCAAACAGAACTACTAAAATGGCAAGACATAAAAAACGGGGAGGCTCTTGCCTACCCTGCTCTCTACTTATTTAATGGACTCATGTATCGGCATATCAAGCGCCAGCATTTGACTGTAGAAGAAAAAGCTTTTCTTAAAGAGAAAGTTTTTATCACATCAGCGCTTTATGGTATTATTCCTGCCCTGAAACCCATTGTTCCCCATCGCCTTGACTTCAATACTAAAGTAAAAATCAAGGGAGAATCTCTAAAGAACTACTGGCGCAAAACTTATGATAACTTTGTTTTGGACAATCCTAGTATTGTGTCACTGTTATCTAGTGAATTTGAAGCTGTTTTTTCACCAAAATTACGAAATCAATTGATAACTCTTAGATTTTTGGAAAATCAAAACGGTCAGTTAAAATCCCATTCCACTATTTCCAAAAAAGCACGCGGAGCCTTTTTAACACAGGTCATTCAGCAACAAACAAAAACGGTAGATGAGCTGAAAACAATCAGTTTTAACGGTTTTAGCTACCAGGATAACCTATCGGAACCCTTAAAATTGATTTTTATAAAGCAGAGTAAATGA","10.50","13.44","27999","MKFLIPTAKEIKEDNKPYPQHLSQKSQILVNHMNALSIEELEKSYKVSPQIAQTELLKWQDIKNGEALAYPALYLFNGLMYRHIKRQHLTVEEKAFLKEKVFITSALYGIIPALKPIVPHRLDFNTKVKIKGESLKNYWRKTYDNFVLDNPSIVSLLSSEFEAVFSPKLRNQLITLRFLENQNGQLKSHSTISKKARGAFLTQVIQQQTKTVDELKTISFNGFSYQDNLSEPLKLIFIKQSK","1945274","","conserved hypothetical protein","Cytoplasm","Several strong matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-240 are 49% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675856); residues 1-240 are 49% similar to conserved hypothetical protein of Streptococcus pneumoniae (gi|15903448).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2081 (3e-65).","

InterPro
IPR005583
Family

Protein of unknown function DUF328
PF03883	$\"[1-241]T$	DUF328

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 23-239 are 38% similar to a (PROTEOME COMPLETE CJ0984 NMB0895) protein domain (PD017420) which is seen in Q9X4U4_STRSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:23:04 2002","Sun Jan 6 15:51:06 2002","Sun Jan 6 15:52:02 2002","Sun Jan 6 15:51:06 2002","","Sun Jan 6 15:51:06 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1878 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 15:52:02 2002","","No significant hits to the NCBI PDB database.","SMU.2070","","Residues 1 to 241 (E-value = 1.2e-59) place SMu1878 in the DUF328 family which is described as Protein of unknown function (DUF328) (PF03883)","Sun Jan 6 15:51:06 2002","24380405","","","","","","1","","","SMU.2070","736" "SMu1879","1945953","1945348","606","ATGACTTGGAACACACCGAAACCAGGAGAGTGGAAGAGTGAAGAACTAAGTAAGGGACGTATTATTGATTATAAGGCCTTTAATTTTGTTGATGGAGAAGGCGTGCGTAATTCTCTTTATGTAGCAGGTTGCATGTTTCATTGTGAAGGCTGTTATAATGTTGCAACTTGGTCTTTTGATGCAGGAATTCCTTATACACAGGAATTGGAAGAACAGATTATGGAAGATTTAGCACAGCCTTATGTTCAAGGTTTAACGCTTTTAGGCGGAGAACCCTTTTTGAATACGGGTATTCTTTTGCCTTTACTAAAAAGGATTCGTAAAGAGCTTCCGGAGAAAGATATTTGGTCTTGGACAGGCTATACTTGGGAAGAATTAATGCTGGAAACTCCTGATAAATTGGAAATGCTTAATTTGCTTGATATTTTGGTGGATGGACGTTTTGATAAATCCAAGAAAAATCTAATGCTGCAATTCCGAGGTTCTTCCAATCAACGTATCATTGATGTGCCAAAATCGCTAGCTTCAGGTCAAGTTGTGATTTGGGATAAACTCAATGATGGCAAACAGACCTATGAACAAATTGACAGAGATGGACTGATATAG","4.60","-8.89","23087","MTWNTPKPGEWKSEELSKGRIIDYKAFNFVDGEGVRNSLYVAGCMFHCEGCYNVATWSFDAGIPYTQELEEQIMEDLAQPYVQGLTLLGGEPFLNTGILLPLLKRIRKELPEKDIWSWTGYTWEELMLETPDKLEMLNLLDILVDGRFDKSKKNLMLQFRGSSNQRIIDVPKSLASGQVVIWDKLNDGKQTYEQIDRDGLI","1945366","For other 'nrd' genes see SMu0609 (nrdG),(nrdF); SMu0611 (nrdH); SMu1882 (nrdD); SMu1135 (nrd); SMu1618 (nrdI), (nrd) and SMu0610 (nrdE).For ribonucleotide reductase, small subunit see SMu0609. For ribonucleotide reductase, large subunit see SMu0610. From GenBank (gi:1171763): In H.influenzae, this protein activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. It catalyzes the reaction S-adenosyl-L-methionine + dihydroflavodoxin + [formate acetyltransferase]-glycine = 5'-deoxyadenosine + methionine + flavodoxin + [formate acetyltransferase]-glycine-2-YL radical. It is cytoplasmic and belongs to the organic radical activating enzymes family.","anaerobic ribonucleoside-triphosphate reductase activating protein (NrdD activating enzyme, generating glycyl radical)","Cytoplasm","Numerous matches in gapped BLAST to anaerobic ribonucleoside-triphosphate reductase activating protein; e.g. residues 4-198 are 87% similar to NrdD activating enzyme of Streptococcus pneumoniae (gi15902229); residues 3-201 are 84% similar to anaerobic ribonucleotide reductase activator of Streptococcus pyogenes (gi15675857).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2082 (1e-102).","

InterPro
IPR007197
Domain

Radical SAM
PF04055	$\"[38-131]T$	Radical_SAM

InterPro
IPR012837
Family

Ribonucleoside-triphosphate reductase activating, anaerobic
TIGR02491	$\"[20-171]T$	NrdG

noIPR
unintegrated

unintegrated
SSF102114	$\"[6-137]T$	SSF102114

","BeTs to 4 clades of COG0602COG name: Organic radical activating enzymesFunctional Class: OThe phylogenetic pattern of COG0602 is amTK-q-cEB-Huj------xNumber of proteins in this genome belonging to this COG is 2","***** IPB001989 (Radical activating enzymes) with a combined E-value of 7e-14. IPB001989A 30-57 IPB001989B 84-95 IPB001989C 142-147","Residues 27-57 are 90% similar to a (ACTIVATING ANAEROBIC REDUCTASE ENZYME) protein domain (PD016381) which is seen in Q9CIT2_LACLA.Residues 62-165 are 83% similar to a (ANAEROBIC REDUCTASE) protein domain (PD385747) which is seen in Q9ZAX5_BBBBB.Residues 166-201 are 69% similar to a (ANAEROBIC REDUCTASE) protein domain (PD200240) which is seen in Q9CIT2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Sep 19 17:09:50 2006","Sun Jan 6 13:56:32 2002","Tue Sep 19 17:08:44 2006","Mon Apr 1 15:57:38 2002","Sun Jan 6 13:56:32 2002","Sun Jan 6 13:56:32 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1879 is paralogously related (blast p-value < 1e-3) to SMu1542 and SMu0444; both predicted pyruvate-formate lyase activating enzyme; SMu0832, a predicted conserved hypothetical protein.","Mon Apr 15 13:54:31 2002","","No significant hits to the NCBI PDB database.","SMU.2071c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 13:56:32 2002","","","","Masalha,M., Borovok,I., Schreiber,R., Aharonowitz,Y. and Cohen,G. Analysis of Transcription of the Staphylococcus aureus Aerobic Class Ib and Anaerobic Class III Ribonucleotide Reductase Genes in Response to Oxygen. J. Bacteriol. 183 (24), 7260-7272 (2001) PubMed: 11717286.","","Sun Jan 6 14:44:04 2002","1","","","SMU.2071c","493" "SMu1880","1946470","1945913","558","ATGTTAAAATTACGTAGACCGACTTTAGGAGATAAAGAAGCCATTTTGGATATGATGGTAGAGTTTGAACAATTGCAAACAGCTCATGACGGTGGCTTTTGGGGAAAAACTGACTGTGATTGTTTTGATTATGATCAATGGCTGCAAAACAACCTAGATAAGGAGATGGGACTTAAACTGCCTAAAAATTTTGTACCTGCGATTCAATTCGTGTCATTTGATGATAGTGGCAGGGCAATAGGTTTTTTACATATTCGTTTGCGTCTCAACAATTTTTTAGTTAGTTGCGGTGGTCACATTGGTTATTCTATTCGTCCATCGGCGCGTGGTAAGGGCTATGCTAAAGAGCAGTTGCGCTTGGGCTTATTGGAAGCTAAAGCTAAGAATATTAAAAAAGTACTGATCACCTGTCATAATGATAATGCAGCTAGTCGGGCAGTTATTTTGGCTAATGGTGGTGTTTTAGAAGATATCAGAAATCAGATAGAGCGTTATTGGATAGATTTGGAGGGGAAGGATGACTTGGAACACACCGAAACCAGGAGAGTGGAAGAGTGA","6.70","-0.98","21078","MLKLRRPTLGDKEAILDMMVEFEQLQTAHDGGFWGKTDCDCFDYDQWLQNNLDKEMGLKLPKNFVPAIQFVSFDDSGRAIGFLHIRLRLNNFLVSCGGHIGYSIRPSARGKGYAKEQLRLGLLEAKAKNIKKVLITCHNDNAASRAVILANGGVLEDIRNQIERYWIDLEGKDDLEHTETRRVEE","1945931","","possible acetyltransferase, GNAT family","Cytoplasm","Some moderate matches in gapped BLAST to both hypothetical proteins and acetyltransferases; e.g. residues 2-169 are 62% similar to acetyltransferase, GNAT family, of Streptococcus pneumoniae (gi15900140); residues 2-173 are 52% similar to hypothetical protein of Streptococcus pyogenes (gi15675858).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2083 (2e-53).","

InterPro
IPR000182
Domain

GCN5-related N-acetyltransferase
PF00583	$\"[71-154]T$	Acetyltransf_1
PS51186	$\"[2-176]T$	GNAT

noIPR
unintegrated

unintegrated
G3DSA:3.40.630.30	$\"[2-158]T$	G3DSA:3.40.630.30
SSF55729	$\"[1-161]T$	SSF55729

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 44-167 are 44% similar to a (PROTEOME COMPLETE VCA0631 PM0033) protein domain (PD338839) which is seen in Q9KFH6_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:22:14 2002","Tue Jul 18 10:20:42 2006","Tue Jul 18 10:20:42 2006","Sun Jan 6 13:46:03 2002","","Sun Jan 6 13:46:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1880 is paralogously related (blast p-value < 1e-3) to SMu1348,a predicted conserved hypothetical protein; possible acetyltransferase.","Mon Apr 15 13:55:17 2002","","No significant hits to the NCBI PDB database.","SMU.2072c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 13:46:03 2002","24380407","","","","","","1","","","SMU.2072c","865" "SMu1881","1946635","1946504","132","ATGGGAAAATATCAATTAGATTATAAAGGAATGCAGCAAGTAGAAAGATTTCATGAGAAGCATTCGAATGTTAAGGATGATAAAAAAGCACGTGTGCAGGCTTTGTTGAAAAAAGTTAGAAAGAAAAAATAG","11.00","9.46","5199","MGKYQLDYKGMQQVERFHEKHSNVKDDKKARVQALLKKVRKKK","1946522","","conserved hypothetical protein","Extracellular, Periplasm, Cytoplasm","No significant matches using gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2085 (3e-08).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 11:01:38 2006","Tue Aug 29 11:01:38 2006","Tue Aug 29 11:01:38 2006","Sun Jan 6 13:41:22 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1881 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:21:14 2002","","No significant hits to the NCBI PDB database.","SMU.2073c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 13:41:22 2002","24380408","","","","","","1","","","SMU.2073c","1033" "SMu1882","1948936","1946732","2205","ATGATTGCACTTGAGAAAGAAAATATTTTTGTGAAACCAGATGTCATCGTGATTAAACGTGATGGACGTCACGTTGCTTTTGATAAGGATAAAATTTATCAGGCTATTGTCAGGGCAAGTAATCAAGTGACAGAATTAACACCTTTTATTGAAGCAAAATTATCAGGTATTGCTGATCGTGTTGTCGCTGAGATTTATGAACGTTTTACTGAAAATATTAAAATTTATGAAATTCAAAATATTGTAGAGCATGAGCTGCTGCAGGCTGGAGAGTACGTTATCGCTCAGGAATATATTAATTACCGTGCGAAACGTGATTTTGAGCGTTCTCAGGCAACGGATATCAACTTTACCATTGATAAATTAATTAACAAGGATCAAGCTGTTGTTAACGAGAACGCCAACAAAGACAGTGATGTTTTCAATACACAGCGTGATTTAACAGCTGGTATTGTTGGAAAATCAATTGGGCTTAAAATGCTGCCAGAACATGTTGCCAATGCTCATCTTAAAGGAGATATTCATTTTCATGATTTGGACTACAGTCCTTATACACCAATGACTAACTGCTGCTTGATTGATTTTAAAGGTATGCTGCATTCGGGTTTTAAGATTGGTAATGCTGAGGTTGAAAGTCCTAAATCTATTCAAACAGCGACAGCTCAAATTTCACAAATTATTGCGAATGTTGCTTCCAGTCAGTATGGTGGCTGTTCAGCAGATCGTATTGATGAAACTTTAGCTCCTTATGCAGAATTAAATTATCAAAAGCATTTAAAGGATGCTGAAAAATGGGTCAGTGAAGATAAGCGTGAAGATTATGCGCGTGAAAAGACGAAAAAAGATATTTACGATGCTATGCAAAGTCTAGAGTATGAAATTAACACACTCTTCACATCAAATGGTCAAACACCTTTTACATCGCTTGGTTTTGGTCTTGGTAAGGATTGGTTTGAACGCGAGATTCAAAAAGCGATTCTTAACATCCGTATTAAAGGATTGGGCAGTGAACATCGTACCGCAATTTTTCCTAAATTAATTTTTACTTTGAAACGCGGATTGAACTTAGAACCAGGAACGCCCAACTATGATATTAAGAAACTAGCGCTTGAATGTGCTACTAAGCGTATGTATCCTGACATGCTGTCTTATGAAAAAATTATTGAATTAACAGGCTCGTTCAAGGTTCCTATGGGCTGCCGTTCTTTCCTTCAAGGATGGAAGGATGAAAATGGCGTTGAAGTTAATTCAGGTCGTATGAATCTTGGAGTTGTTACGGTTAATTTACCTCGTATTGCCCTTGAGTCAAATGGGAATATTGATAAGTTTTGGGATATCTTTAAGGAAAAAATGGCTATTGCTAAAGATGCCCTAGTTTATCGTGTTGAACGTGTCAAGGAGGCAACGCCGGCTAATGCTCCGATTCTTTATCAGTATGGAGCTTTTGGTAAGCGTCTTGGCAAGGATGATTCTGTTGATGAACTTTTTAAAGAACGTCGCGCCACTGTTTCACTTGGATATATTGGACTTTATGAAGTAGCGACAGTCTTCTATGGCGGTAACTGGGAATCAAATCCTGTTGCTAAGGATTTTACCATTGATATTGTTCGTCAAATGAAGGATCTTTGTGGCAAGTGGTCAAATGAATACGATTATCATTTTTCGGTTTATTCAACACCATCTGAAAGTTTAACGGATCGTTTCTGCCGTTTGGATACTGAAAAGTTTGGTATCATCAAAGATATCACTGATAAAGAATATTATACGAATTCTTTCCACTATGATGTTCGCAAAAATCCAACACCGTTTGAAAAGTTAGATTTTGAAAAAGACTATCCGGATGCAGGTGCCACAGGTGGTTTCATTCATTACTGTGAATACCCTGTTCTTCAACAAAATCCAAAAGCACTTGAAGCGGTGTGGGATTATGCTTATGATCGTGTCGGTTATCTGGGAACAAATACACCAATTGATCATTGCTATAAGTGTGATTTTGAAGGCGATTTTACACCGACAGAACGTGGTTTTATGTGCCCAAATTGTGGCAATACAGACCCTAAAACTGCTGATGTTGTTAAGAGAACGTGTGGTTATCTTGGCAACCCACAGGCTCGTCCAATGGTGAATGGCCGCCATAAGGAAATCTCAGCACGTGTCAAACACATGAATGGTTCAACCATTAAAAATCCGGGGCACAAGGCATAG","6.30","-6.68","83457","MIALEKENIFVKPDVIVIKRDGRHVAFDKDKIYQAIVRASNQVTELTPFIEAKLSGIADRVVAEIYERFTENIKIYEIQNIVEHELLQAGEYVIAQEYINYRAKRDFERSQATDINFTIDKLINKDQAVVNENANKDSDVFNTQRDLTAGIVGKSIGLKMLPEHVANAHLKGDIHFHDLDYSPYTPMTNCCLIDFKGMLHSGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCSADRIDETLAPYAELNYQKHLKDAEKWVSEDKREDYAREKTKKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGKDWFEREIQKAILNIRIKGLGSEHRTAIFPKLIFTLKRGLNLEPGTPNYDIKKLALECATKRMYPDMLSYEKIIELTGSFKVPMGCRSFLQGWKDENGVEVNSGRMNLGVVTVNLPRIALESNGNIDKFWDIFKEKMAIAKDALVYRVERVKEATPANAPILYQYGAFGKRLGKDDSVDELFKERRATVSLGYIGLYEVATVFYGGNWESNPVAKDFTIDIVRQMKDLCGKWSNEYDYHFSVYSTPSESLTDRFCRLDTEKFGIIKDITDKEYYTNSFHYDVRKNPTPFEKLDFEKDYPDAGATGGFIHYCEYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDHCYKCDFEGDFTPTERGFMCPNCGNTDPKTADVVKRTCGYLGNPQARPMVNGRHKEISARVKHMNGSTIKNPGHKA","1946750","For other 'nrd' genes see SMu0609 (nrdG),(nrdF); SMu0611 (nrdH); SMu1879 (nrdG); SMu1135 (nrd); SMu1618 (nrdI), (nrd) and SMu0610 (nrdE). For ribonucleotide reductase, small subunit see SMu0609. For ribonucleotide reductase, large subunit see SMu0610. From GenBank (gi:128568): In E. coli, NrdD catalyzes the reaction: 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O = ribonucleoside triphosphate + reduced thioredoxin, requiring a cofactor. NrdD contains an iron-sulfur cluster and requires S-adenoylmethionine, which is probably a glycine radical generator. It is probably induced by an NrdD-activating enzyme under anaerobic conditions by generation of an organic free radical. Exposure of activated NrdD to oxygen may result in cleavage at the glycine residue harboring its organic radical with loss of the 31 C-terminal amino acids.","anaerobic ribonucleoside-triphosphate reductase","Cytoplasm","Numerous strong matches in gapped BLAST to anaerobic ribonucleoside-triphosphate reductase; e.g. residues 1-733 are 80% similar to ribonucleotide reductase, class III, anaerobic of Streptococcus pneumoniae (gi15902227); residues 14-725 are 73% similar to anaerobic ribonucleoside-triphosphate reductase of Lactococcus lactis (gi15672255).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2086 (0.0).","

InterPro
IPR001150
Domain

Formate C-acetyltransferase glycine radical
PF01228	$\"[596-703]T$	Gly_radical
PS00850	$\"[692-700]?$	GLY_RADICAL_1
PS51149	$\"[598-724]T$	GLY_RADICAL_2

InterPro
IPR005144
Domain

ATP-cone
PF03477	$\"[15-109]T$	ATP-cone
PS51161	$\"[15-109]T$	ATP_CONE

InterPro
IPR008926
Domain

Ribonucleotide reductase R1 subunit, N-terminal
SSF48168	$\"[20-82]T$	Ribonucleo_red_N

InterPro
IPR012833
Domain

Ribonucleoside-triphosphate reductase, anaerobic
TIGR02487	$\"[131-721]T$	NrdD

noIPR
unintegrated

unintegrated
G3DSA:3.20.70.20	$\"[137-704]T$	G3DSA:3.20.70.20
PIRSF000358	$\"[14-723]T$	An_RNR_III_large
PTHR21075	$\"[17-723]T$	PTHR21075
SSF51998	$\"[137-704]T$	SSF51998

","BeTs to 4 clades of COG1328COG name: Oxygen-sensitive ribonucleoside-triphosphate reductase NrdDFunctional Class: FThe phylogenetic pattern of COG1328 is -Mtk--v-e--h---------Number of proteins in this genome belonging to this COG is 1","***** IPB001150 (Pyruvate formate-lyase, glycine radical) with a combined E-value of 2.6e-24. IPB001150A 368-378 IPB001150B 671-720","Residues 397-563 are 45% similar to a (ANAEROBIC REDUCTASE NDP RADICAL) protein domain (PD340055) which is seen in Q9T0V5_BPT4.Residues 564-718 are 85% similar to a (REDUCTASE ANAEROBIC PROTEOME COMPLETE) protein domain (PD017554) which is seen in Q9ZAX6_BBBBB.Residues 129-317 are 74% similar to a (ANAEROBIC REDUCTASE) protein domain (PD039550) which is seen in Q9ZAX6_BBBBB.Residues 17-114 are 57% similar to a (REDUCTASE RIBONUCLEOTIDE PROTEOME) protein domain (PD010634) which is seen in Q9ZAX6_BBBBB.Residues 320-393 are 87% similar to a (ANAEROBIC REDUCTASE NDP RADICAL) protein domain (PD406856) which is seen in Q9ZAX6_BBBBB.Residues 320-563 are 74% similar to a (PROTEOME COMPLETE ANAEROBIC REDUCTASE) protein domain (PD009884) which is seen in Q9CIT3_LACLA.Residues 158-257 are 32% similar to a (PROTEOME COMPLETE) protein domain (PD011513) which is seen in Y832_METJA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 10:50:14 2006","Thu Aug 24 10:50:14 2006","Thu Aug 24 10:50:14 2006","Mon Apr 1 15:50:46 2002","Sun Jan 6 13:29:59 2002","Sun Jan 6 13:29:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1882 is paralogously related (blast p-value < 1e-3) to SMu0901 and SMu1747, both predicted conserved hypothetical proteins.","Mon Apr 15 14:07:16 2002","Thu Aug 24 10:50:14 2006","pdb1B8BA Chain A, Class Iii Anaerobic Ribonucleotide Triphosp... 622 4e-179","SMU.2074c","","Residues 15 to 109 (E-value = 2.1e-22) place SMu1882 in the ATP-cone family which is described as ATP cone domain (PF03477)Residues 596 to 703 (E-value = 1e-25) place SMu1882 in the Gly_radical family which is described as Glycine radical (PF01228)","Thu Aug 24 10:50:14 2006","","","","Masalha,M., Borovok,I., Schreiber,R., Aharonowitz,Y. and Cohen,G. Analysis of Transcription of the Staphylococcus aureus Aerobic Class Ib and Anaerobic Class III Ribonucleotide Reductase Genes in Response to Oxygen. J. Bacteriol. 183 (24), 7260-7272 (2001) PubMed: 11717286.","","Sun Jan 6 13:39:29 2002","1","","","SMU.2074c","197" "SMu1883","1950606","1949035","1572","ATGGGTTTGGATAAAAGACAAAACAATTATCGGAGAGAAACAACTAAAAAAACAAATGCTAACACTCACTTGAGTGCTGACCAAAACGCAGTTAAAGTGAGTTTTTTACATCGTTTTTATATCGTCATGTTTAGTATTTTTGTCAGTTTTTTTAGTGTGGCCATGCCCTTTTTTACTGATTTTGGCAATGCTCTTCAATCTCAAAATCTTTATACAGGTTTTATGATGACGCAAAATCATTTGCCCTATAGTGATATTTTTTCAACAGGCGGCTTTCTTTACTACGCGGTAATTGCACTTAGTTATCTTTTAGGAGGTAGTATTTGGCTGGTTTTAGTCCAGTTTGCTAGTTTTTACTTTTCGGGTATCTATCTTTATAAGATTGTTTATCATATGACTGGCAAAGAAGAGGTGACGATTAATACTATATTGCTCTTTTATTTGGCTAATTTTGCTCTGGGTTTTGGAGGGCTGTATCCTGTTCAATTTGCTATGCCTTTTGTGTTCTTGTCCCTTTGGTTTTTAACCAAATATTTTGCAGGTTTGACAAGAGATGAAGGATTTATTATTTATGGCTTGACAGGAGCATTAGCTTATTTAATCGAACCACGGACTCTTTTCTTTTGGCTGGTGTCTTTAGTAATTATCTGTATCTATAATGTGAAGCATCATCAGCATGCTCGTGGATTCTATCAGTTTCTTTGTATTGTTTTTGGTGGTATCCTAGTATTTTATATTTTGGGCTATTTTGTTTTAAATATGCAAATTCTGTCATCCTATATCGCTCAAGCTGGGACTTACTACTTTACTCATTTTGCTCTTGGGAAAGATGATATTTTACTGACAATTCTCTTTCAAATTTTTATTCTCTTTGCTTCAGGTTTACTGATGGGTGCTTTAACTTTTTTCAATCATATCAAGCGTGAAAATGATCGCGATGACTTGATTAAATCTATTGTCTTTTTAAGTTTTGTTTTTAGTTTGATTTTTATTTTATTATCACAGAGTTTTGCAACCTATCAATTTTTGCTGCTTTTACCTTTTGGTCTTGTCTTGACTGGTCTTTATCTTGATGATGAATATAAGGAATCTTTAAAGCGTAAATCACGTCGGCGAAAACAACATAGACGTCTATCGCATAAAGTCTTTGATCTTTTTTTACTTAGGCATTTCTACCTTCCTTGTCTTTTATTTGCTTATGGTTTAGCTCAGCCTAGTATTCACTACATTTCTTCTTATCATTTAAATCAGGAACGTGCTCAAATTGCTGATTATATTAGAGAAAATACAGATGAAAAAACAAGAATTTATGCATGGGATTCCAGTGCAAAAATTTACTTTGACGCTAGTCGGCGCTCTAGTGCACAATTCCCTTTGCCAATGGTTAATACGGCTAAACAATCAAATCGTAAAGCATTAGAAGATGAGCTTTTACAAAATGAAGCTACTTATGTTGCTGTTAATGAGAAATCGAAGCAATTTCCATCGGTTTTAAAACAGAATTTTTCAAATAATTATAAAGTTGTTTCCTTAAAGAATAGTTCAGATTTCACAGTTTATCAGAGAAAATAG","10.20","18.23","60800","MGLDKRQNNYRRETTKKTNANTHLSADQNAVKVSFLHRFYIVMFSIFVSFFSVAMPFFTDFGNALQSQNLYTGFMMTQNHLPYSDIFSTGGFLYYAVIALSYLLGGSIWLVLVQFASFYFSGIYLYKIVYHMTGKEEVTINTILLFYLANFALGFGGLYPVQFAMPFVFLSLWFLTKYFAGLTRDEGFIIYGLTGALAYLIEPRTLFFWLVSLVIICIYNVKHHQHARGFYQFLCIVFGGILVFYILGYFVLNMQILSSYIAQAGTYYFTHFALGKDDILLTILFQIFILFASGLLMGALTFFNHIKRENDRDDLIKSIVFLSFVFSLIFILLSQSFATYQFLLLLPFGLVLTGLYLDDEYKESLKRKSRRRKQHRRLSHKVFDLFLLRHFYLPCLLFAYGLAQPSIHYISSYHLNQERAQIADYIRENTDEKTRIYAWDSSAKIYFDASRRSSAQFPLPMVNTAKQSNRKALEDELLQNEATYVAVNEKSKQFPSVLKQNFSNNYKVVSLKNSSDFTVYQRK","1949053","","conserved hypothetical protein (possible competence-induced protein)","Membrane, Cytoplasm","Few matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 11-523 are 39% similar to Streptococcus pyogenes of Streptococcus pyogenes (gi|15675861). Weak similarity is also shown to competence-induced protein, Ccs4, of S.pneumoniae; residues 55-250 are 29% similar to this Ccs4 protein.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2087 (7e-97).","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[169-354]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[39-59]?$ $\"[83-103]?$ $\"[108-126]?$ $\"[155-175]?$ $\"[180-199]?$ $\"[205-223]?$ $\"[233-253]?$ $\"[279-299]?$ $\"[314-334]?$ $\"[340-358]?$ $\"[382-402]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 54-277 are 35% similar to a (PROTEOME COMPLETE) protein domain (PD402105) which is seen in Q9CJ47_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 18:09:00 2002","Sun Jan 6 13:11:27 2002","Thu Oct 10 18:09:00 2002","Sun Jan 6 13:10:29 2002","","Sun Jan 6 13:10:29 2002","yes","Thu Oct 10 18:09:00 2002","SMu1883 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 13:11:27 2002","","No significant hits to the NCBI PDB database.","SMU.2075c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 13:10:29 2002","24380410","","","","","","1","","","SMU.2075c","494" "SMu1884","1950771","1950643","129","ATGAAAACGAAAGAAAGCTTAACACAGCAAGAAAAAAAGTTTTTGAAAGACTATGACAGGAAGTCTCTGCATCATTTTAGAGATATTTTAACTTATTGCTTTATCTTGGATAAATTGACTAATAAGTAG","10.20","4.41","5187","MKTKESLTQQEKKFLKDYDRKSLHHFRDILTYCFILDKLTNK","1950661","","hypothetical protein","Cytoplasm, Extracellular","No significant matches using gapped BLAST.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2088 (5e-05).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:19:42 2002","Sun Jan 6 13:01:06 2002","Sun Jan 6 13:01:06 2002","Sun Jan 6 13:01:06 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1884 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:19:42 2002","","No significant hits to the NCBI PDB database.","SMU.2076c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 13:01:06 2002","24380411","","","","","","1","","","SMU.2076c","" "SMu1885","1951139","1950840","300","ATGTCACATAATCATGAACAAGAGCATGATCTTATCACGCTTGTTGATGAACAAGGAAATGAAACTTTGTTCGAAGTTCTTTTGACTATTGATGGTAAAGAGGAATTTGGAAAAAATTATGTTCTCTTGGTTCCAGCGGGTGCTGAAGAAGATGCTGATGGTCAAATTGAAATTCAGGCCTATTCATTTACTGAAAATGAAGATGGAACAGAAGGGGCTCTTCAACCTATTCCAGAAGATGCTGATGCTGAATGGATTATGATCGAAGAAGTCTTTAATAGTTTTTTAGATGAAGATTGA","3.50","-25.27","11127","MSHNHEQEHDLITLVDEQGNETLFEVLLTIDGKEEFGKNYVLLVPAGAEEDADGQIEIQAYSFTENEDGTEGALQPIPEDADAEWIMIEEVFNSFLDED","1950858","","conserved hypothetical protein","Cytoplasm","Few matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-99 are 83% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675862).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2089 (2e-46).","

InterPro
IPR009711
Family

Protein of unknown function DUF1292
PF06949	$\"[9-98]T$	DUF1292

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 8-98 are 72% similar to a (PROTEOME COMPLETE YRZB BH1270) protein domain (PD064816) which is seen in Q9CJ62_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:19:17 2002","Sun Jan 6 13:00:19 2002","Sun Jan 6 13:00:19 2002","Sun Jan 6 13:00:19 2002","","Sun Jan 6 13:00:19 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1885 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:19:17 2002","","No significant hits to the NCBI PDB database.","SMU.2077c","","Residues 9 to 98 (E-value = 2.4e-52) place SMu1885 in the DUF1292 family which is described as Protein of unknown function (DUF1292) (PF06949)","Sun Jan 6 13:00:19 2002","24380412","","","","","","1","","","SMU.2077c","866" "SMu1886","1951639","1951220","420","ATGAGAATAATAGGACTGGATGTTGGTTCCAAAACAGTTGGTGTTGCTGTTAGTGACCCACTGGGGTTTACAGCACAGGGTCTTGAAATTATTCCTATTAATGAAGCTAAAGGAGAGTTTGGCTTTGATCGTCTAGCTGATTTGGTTAAGGACTACAAGGTTGAAAAGTTTGTAGTTGGTTTACCTAAAAATATGAATAATACAAGTGGTCCGCGTGTTGAGGCTAGTCAGGCTTATGGTAAGAAAATCAAAGAACTTTTCGATTTACCTGTTGAATATCAGGATGAACGTTTGACGACTGTTCAAGCTGAACGAATGCTAGTTGAGCAGGCTGATGTTAGTCGCGGTAAGCGAAAAAAGGTTATTGATAAGTTGGCTGCTCAGCTGATTTTGCAAAATTATTTGGATCGTATGTTTTAA","9.00","1.00","15530","MRIIGLDVGSKTVGVAVSDPLGFTAQGLEIIPINEAKGEFGFDRLADLVKDYKVEKFVVGLPKNMNNTSGPRVEASQAYGKKIKELFDLPVEYQDERLTTVQAERMLVEQADVSRGKRKKVIDKLAAQLILQNYLDRMF","1951238","","conserved hypothetical protein; possible Holliday junction resolvase-like protein","Cytoplasm","Many matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-139 are 83% similar to conserved hypothetical protein of Streptococcus pneumoniae (gi15457719). Also weaker matches to possible endonucleases; residues 1-136 are 51% similar to predicted endonuclease involved in recombination of Clostridium acetobutylicum (gi15894957).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2090 (2e-66).","

InterPro
IPR005227
Family

Resolvase, holliday junction-type, YqgF-like
PF03652	$\"[1-137]T$	UPF0081
TIGR00250	$\"[4-136]T$	HJR_YqgF

InterPro
IPR006641
Domain

Resolvase, RNase H-like fold
SM00732	$\"[1-103]T$	YqgFc

InterPro
IPR012337
Domain

Polynucleotidyl transferase, Ribonuclease H fold
SSF53098	$\"[1-139]T$	RNaseH_fold

noIPR
unintegrated

unintegrated
G3DSA:3.30.420.140	$\"[2-136]T$	G3DSA:3.30.420.140

","BeTs to 9 clades of COG0816COG name: Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis)Functional Class: LThe phylogenetic pattern of COG0816 is -----qvcebrhujgp--inxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 4-135 are 35% similar to a (MG291.1 PROTEOME COMPLETE HOMOLOG) protein domain (PD008222) which is seen in Q9LFA0_ARATH.Residues 81-138 are 44% similar to a (CPN0237/CP0525/CPJ0237) protein domain (PD396018) which is seen in Y237_CHLPN.Residues 24-136 are 60% similar to a (PROTEOME COMPLETE PA0404 CT184) protein domain (PD219509) which is seen in YRRK_BACSU.Residues 3-135 are 26% similar to a (XF2227) protein domain (PD398564) which is seen in YM27_XYLFA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Aug 21 16:09:52 2006","Mon Aug 21 16:09:52 2006","Mon Aug 21 16:09:52 2006","Tue Oct 8 14:18:00 2002","","Sun Jan 6 12:52:00 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1886 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 12:57:31 2002","","No significant hits to the NCBI PDB database.","SMU.2078c","","Residues 1 to 137 (E-value = 7.5e-52) place SMu1886 in the UPF0081 family which is described as Uncharacterised protein family (UPF0081) (PF03652)","Sun Jan 6 12:52:00 2002","24380413","","","","","","1","","","SMU.2078c","737" "SMu1887","1951905","1951636","270","ATGGGATTTACAGATGAAACGGTCCGTTTTAACCTTGACGATGGTAATAAGAAGGAAATTAGCGAAACCTTGACTCATGTCTATCGTTCTTTGGAAGAAAAAGGTTATAATCCAATCAATCAAATTGTGGGTTATGTCTTAAGTGGGGATCCTGCTTATGTGCCTCGCTATAATGACGCTCGAAATCAAATTCGAAAATATGAACGTGACGAAATTGTTGAAGAATTAGTGCGTTACTATTTGCAAGGGAATGGGATTGATTTAAAATGA","4.80","-3.77","10418","MGFTDETVRFNLDDGNKKEISETLTHVYRSLEEKGYNPINQIVGYVLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLQGNGIDLK","1951654","","conserved hypothetical protein","Cytoplasm","Several moderate matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-89 are 91% similar to hypothetical protein of Streptococcus pyogenes (gi|13623098).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2091 (2e-45).","

InterPro
IPR009309
Family

Protein of unknown function DUF965, bacterial
PF06135	$\"[4-82]T$	DUF965

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-88 are 69% similar to a (PROTEOME COMPLETE BH1268 YBEA) protein domain (PD279672) which is seen in Q9CJ64_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:18:31 2002","Sun Jan 6 12:51:17 2002","Sun Jan 6 12:51:17 2002","Sun Jan 6 12:51:17 2002","","Sun Jan 6 12:51:17 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1887 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:18:31 2002","","No significant hits to the NCBI PDB database.","SMU.2079c","","Residues 4 to 82 (E-value = 5.8e-52) place SMu1887 in the DUF965 family which is described as Bacterial protein of unknown function (DUF965) (PF06135)","Sun Jan 6 12:51:17 2002","24380414","","","","","","1","","","SMU.2079c","867" "SMu1888","1952073","1952507","435","ATGAAAGTAAAAATTATCAAGGATTCAAACTTTAAGGAACCCTTACTCCAAATCTATACACGTCATATTGATAAACAAACGCAAAGAGTGATTGATTTTATTCAACAAAGACCTAATATCGTTTATGGTTACAAAAATAAATGCTTAGAGTTTATCCCACTAGAAAAAGTGATTCGTATTTTCACGGAAAACAAACAGGTCTTAATTCAAACACTAACCGATACCTATTTAGCTAAACAAAGACTCTACTTTTTTGAGCAAGAATTAGGAACACCTTTTATTCGTATCTCCCAAGGTGAAATCATCAATATCAAATATATTAAACAATTGAATTTAACCATCCGAGGCAGCATTGAAGTGACTTTCAAAAATGGAACAGTCAGTTTCGTGGCTAGGCGAAGTTTGAAACGCTTCAAAGAACAATTAAATCTTTAA","10.80","12.18","17171","MKVKIIKDSNFKEPLLQIYTRHIDKQTQRVIDFIQQRPNIVYGYKNKCLEFIPLEKVIRIFTENKQVLIQTLTDTYLAKQRLYFFEQELGTPFIRISQGEIINIKYIKQLNLTIRGSIEVTFKNGTVSFVARRSLKRFKEQLNL","1952519","","conserved hypothetical protein","Cytoplasm","Similar to Str0052.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0183 (7e-05).","

InterPro
IPR007492
Domain

LytTr DNA-binding region
PF04397	$\"[47-143]T$	LytTR
PS50930	$\"[41-144]T$	HTH_LYTTR

InterPro
IPR012360
Family

LytTR_ LMO transcriptional regulator, putative
PIRSF031486	$\"[1-144]T$	LMO_LytTR

noIPR
unintegrated

unintegrated
tmhmm	$\"[10-30]?$ $\"[51-73]?$ $\"[79-99]?$ $\"[111-131]?$	transmembrane_regions

noIPR
unintegrated

unintegrated
signalp	$\"[1-39]?$	signal-peptide
tmhmm	$\"[15-37]?$ $\"[43-63]?$ $\"[68-88]?$ $\"[117-137]?$	transmembrane_regions

InterPro
IPR006504
Family

Conserved hypothetical protein, ArsC related
TIGR01617	$\"[2-115]T$	arsC_related

InterPro
IPR006660
Family

Arsenate reductase and related
PF03960	$\"[5-115]T$	ArsC

InterPro
IPR012335
Domain

Thioredoxin fold
G3DSA:3.40.30.10	$\"[1-115]T$	Thioredoxin_fold

InterPro
IPR012336
Domain

Thioredoxin-like fold
SSF52833	$\"[1-125]T$	IPR012336

","BeTs to 3 clades of COG1393COG name: Arsenate reductase, E.coli typeFunctional Class: PThe phylogenetic pattern of COG1393 is --------EB-H--gp-----Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 2-95 are 23% similar to a (ARSENATE REDUCTASE ARSENICAL) protein domain (PD004262) which is seen in Q9K785_BACHD.Residues 2-110 are 51% similar to a (COMPLETE PROTEOME OXIDOREDUCTASE MG127) protein domain (PD030877) which is seen in Q9ETA4_LACLA.Residues 1-119 are 36% similar to a (PROTEOME YNEH COMPLETE) protein domain (PD396666) which is seen in Q9CFZ8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:07:57 2002","Sun Jan 6 12:33:57 2002","Sun Jan 6 12:33:57 2002","Mon Apr 15 14:14:00 2002","","Sun Jan 6 12:33:57 2002","yes","Wed Oct 9 10:06:06 2002","SMu1891 is paralogously related (blast p-value < 1e-3) to SMu1044,a predicted conserved hypothetical protein and SMu1503, a predicted arsenate reductase.","Mon Apr 15 14:14:00 2002","","No significant hits to the NCBI PDB database.","SMU.2084c","","Residues 5 to 115 (E-value = 1.4e-50) place SMu1891 in the ArsC family which is described as ArsC family (PF03960)","Sun Jan 6 12:33:57 2002","24380418","","","","","","1","","","SMU.2084c","738" "SMu1892","1955606","1954455","1152","TTGGCCAAAAGAATAAAAAAGACAGAAGAAATAACGAAAAAATTTGGTGATGAGCGTAAGAAAGCTCTTGATGATGCTTTGAAAAACATCGAAAAAGATTTTGGTAAAGGTGCAGTTATGCGTCTGGGTGAACGCGCTGAACAAAAGGTTCAGGTGATGAGTTCAGGAAGTCTGGCTCTTGATATTGCTCTTGGGGCAGGCGGTTATCCAAAAGGGCGTATCGTTGAGATTTACGGGCCAGAATCTTCTGGTAAGACAACTGTCGCTCTTCATGCTGTTGCTCAGGCGCAAAAAGATGGCGGTATTGCCGCTTTCATTGATGCAGAACATGCCCTTGATCCAGCCTATGCTGCTGCTCTTGGTGTTAATATTGATGAGCTTTTGCTTTCACAACCAGATTCAGGAGAACAGGGTCTTGAAATTGCAGGGAAATTGATTGATTCTGGCGCTGTTGATTTAGTTGTTGTTGACTCAGTGGCAGCTTTAGTACCACGTGCGGAGATTGACGGAGATATTGGTGATAGTCATGTTGGCTTACAAGCACGCATGATGAGTCAAGCGATGCGTAAATTATCAGCTTCAATAAATAAAACAAAAACCATTGCCATTTTTATTAATCAATTGCGGGAAAAAGTTGGTATTATGTTTGGTAATCCAGAAACAACCCCTGGCGGGCGTGCCTTGAAGTTTTATTCTTCTGTGCGTCTTGATGTCCGTGGCAATACTCAAATTAAAGGAACCGGGGAACAAAAAGACAGCAATATTGGTAAAGAGACCAAAATTAAAGTTGTTAAAAATAAAGTTGCTCCACCATTTAAGGAAGCTTTTGTAGAAATTATATATGGTGAAGGCATTTCTCGTACAGGTGAATTAGTTAAGATTGCCAGTGATTTGGGAATTATCCAAAAAGCTGGAGCTTGGTACTCTTATAATGGTGAAAAAATTGGGCAAGGTTCTGAAAATGCTAAAAAATTCCTAGCTGATAATCCAGAAATTTTTGATGACATCGATCATAAAGTGCGTGTTCAATATGGTTTAATTGAGGAAGATAATACTGAAGAAAAACAGTCTTCTAAAGAAAAAGAAACTGATGAGAAAGCTGACAAAAACCTTGTTTTAGAGCTGGATGATACAATTGAGCTTGAAGATTAA","5.10","-8.99","41389","MAKRIKKTEEITKKFGDERKKALDDALKNIEKDFGKGAVMRLGERAEQKVQVMSSGSLALDIALGAGGYPKGRIVEIYGPESSGKTTVALHAVAQAQKDGGIAAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALVPRAEIDGDIGDSHVGLQARMMSQAMRKLSASINKTKTIAIFINQLREKVGIMFGNPETTPGGRALKFYSSVRLDVRGNTQIKGTGEQKDSNIGKETKIKVVKNKVAPPFKEAFVEIIYGEGISRTGELVKIASDLGIIQKAGAWYSYNGEKIGQGSENAKKFLADNPEIFDDIDHKVRVQYGLIEEDNTEEKQSSKEKETDEKADKNLVLELDDTIELED","1954473","For other 'rec' genes see SMu0021 (recO);SMu0532 (recN); SMu0545 (recR),(recM);SMu1956 (recF); SMu0425 (recU) ; SMu1669 (recG); SMu1705 (recD) and SMu1339 (recJ).From GenBank (gi:14195635): In S.pyogenes, this protein can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. This cytoplasmic protein belongs to the RecA family.","recombinase A","Cytoplasm","Numerous strong matches in gapped BLAST to recombinase A proteins (RecA); e.g. residues 1-383 are 79% similar to RecA protein of Streptococcus parasanguinis (gi6225932); residues 1-383 are 79% similar to RecA protein of Streptococcus pyogenes (gi14195635).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2093 (1e-174).","

InterPro
IPR001553
Family

RecA bacterial DNA recombination
PD000229	$\"[170-218]T$	RECA_STRTR_Q9EVV7;
PR00142	$\"[50-72]T$ $\"[76-105]T$ $\"[107-136]T$ $\"[141-170]T$ $\"[179-208]T$ $\"[224-252]T$ $\"[261-290]T$ $\"[315-332]T$	RECA
TIGR02012	$\"[18-342]T$	tigrfam_recA: protein RecA
PS50162	$\"[49-212]T$	RECA_2
PS50163	$\"[213-290]T$	RECA_3
PS00321	$\"[227-235]T$	RECA_1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[71-242]T$	AAA

InterPro
IPR013765
Domain

RecA
PF00154	$\"[21-346]T$	RecA

noIPR
unintegrated

unintegrated
G3DSA:3.30.250.10	$\"[287-345]T$	no description
G3DSA:3.40.50.300	$\"[40-286]T$	no description
PTHR22942	$\"[17-345]T$	RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER
PTHR22942:SF1	$\"[17-345]T$	DNA REPAIR PROTEIN RECA

","BeTs to 15 clades of COG0468COG name: RecA/RadA recombinaseFunctional Class: LThe phylogenetic pattern of COG0468 is AMTKYqvcebRhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001553 (RecA bacterial DNA recombination protein) with a combined E-value of 2.6e-152. IPB001553A 18-44 IPB001553B 63-116 IPB001553C 167-221 IPB001553D 284-337","Residues 21-346 are 88% similar to a (ATP-BINDING DNA-BINDING RECOMBINATION DAMAGE REPAIR) protein domain (PD000229) which is seen in RECA_STRPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 10:59:32 2006","Thu Aug 24 10:59:32 2006","Thu Aug 24 10:59:32 2006","Wed Apr 3 09:13:50 2002","Sun Jan 6 12:12:50 2002","Sun Jan 6 12:12:50 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1892 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 12:24:28 2002","Thu Aug 24 10:59:32 2006","pdb1G18A Chain A, Reca-Adp-Alf4 Complex >gi12084114pdb1G19... 391 9e-110pdb2RECA Chain A, Reca Hexamer Model, Electron Microscopy >gi... 376 3e-105pdb2REB The Structure Of The E. Coli Reca Protein Monomer ... 376 3e-105","SMU.2085c","","Residues 21 to 346 (E-value = 4.1e-230) place SMu1892 in the RecA family which is described as recA bacterial DNA recombination protein (PF00154)","Sun Jan 6 12:12:50 2002","","","Tao,L., Hollingshead,S.K., Suvorov,A.N., Ferretti,J.J. and McShan,W.M. Construction of a Streptococcus pyogenes recA mutant via insertional inactivation, and cloning and sequencing of the complete recA gene. Gene 162 (1), 59-62 (1995) PubMed: 7557418.Martin,B., Garcia,P., Castanie,M.P. and Claverys,J.P. The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls lysogenic induction. Mol. Microbiol. 15 (2), 367-379 (1995) PubMed: 7538190.Pearce,B.J., Naughton,A.M., Campbell,E.A. and Masure,H.R. The rec locus, a competence-induced operon in Streptococcus pneumoniae. J. Bacteriol. 177 (1), 86-93 (1995) PubMed: 7798154.","","Wed Apr 3 09:13:50 2002","","1","","","SMU.2085c","198" "SMu1893","1956902","1955646","1257","ATGAAATCTGAGATCATTGCTGTTGGAACAGAAATTTTAACAGGACAAATTGTTAATACTAATAGTCAATTTTTATCAGAAAAATTCGCAGAATTAGGAATTGATGTTTATTTTCAAACAGCAGTTGGTGATAATGAAGAACGCCTTTTATCTGTTTTGAAAATTGCAAAGGAACGTAGTGATTTAATCGTACTTTGTGGTGGTTTGGGACCAACAGAAGATGATTTAACAAAACAAACCCTAGCAAAATTTTTGAAAAGAGAATTGGTATTTGATAAAACAGCTCAAGAACGTCTAGATGAATTTTTTGCATCACGTCCAACATCTATGCGCACACCAAATAATGAATGTCAGGCGCAGATTATAGCAGGAAGTCAGCCTTTATCTAATAAAACAGGTTTAGCAGTTGGGGGGCTTTTGGAGGCAGATGGAGTGACTTATGTTGTATTACCTGGTCCGCCTAGCGAATTGAAGCCTATGGTTAACAAAGAGTTACTCCCTTATTTATCAAAAACTTCTGAGAAGCTTTATTCTCGTGTGTTACGCTTTTTTGGTATTGGTGAGAGTCATCTAGTGACCTTGTTGCATGACTTAATAGCGGAGCAAACAGATCCCACAATTGCTCCTTATGCTAAGACAGGCGAGGTAACAATACGTTTATCAACAAAAGCCCATAGGCAGAAAGAAGCAGATAGTAAGTTAGATAAGTTGGAAAAGAAAATTATAACTATTGATAACTTGGCTGATTATTTTTATGGTTATGGTGAAGAAAATTCATTACCACAGGTTGTATTTGATCTGCTTAAGGAAAAGGGTAAAACGATTACAGCAGCTGAAAGTTTAACAGCAGGCCTTTTTCAGGCAAGATTAGCAGATTTTGCAGGAGCATCTGATATCTTTAAGGGAGGTTTTATAACTTACAGTATAGAAGAGAAGGCTAGAATGCTAGGTATTCCCTTTGAAGATCTCCAACTTCATGGGGTTGTTAGTGCTTTTACTGCTGAAAAGATGGCAGAGCGCTCCCGCCAGCTGACTCAAGCAGATTTGGCTATTTCTTTAACAGGAGTTGCAGGTCCGGATAGCTTAGAAGGTCAGCCGGCAGGGACAGTTTTTATCGGTTTGTCAAGTTCCAAAAGAACAATGGCAATCAAAGTGTTAATTGGCGGACGCAGTCGGTCTGATGTGCGTTATATCGCTGTTTTACATGCTTTTAATTTAGTACGTCAAACTTTATTATCTCATAAAAATTTAGTATAA","6.30","-2.61","45720","MKSEIIAVGTEILTGQIVNTNSQFLSEKFAELGIDVYFQTAVGDNEERLLSVLKIAKERSDLIVLCGGLGPTEDDLTKQTLAKFLKRELVFDKTAQERLDEFFASRPTSMRTPNNECQAQIIAGSQPLSNKTGLAVGGLLEADGVTYVVLPGPPSELKPMVNKELLPYLSKTSEKLYSRVLRFFGIGESHLVTLLHDLIAEQTDPTIAPYAKTGEVTIRLSTKAHRQKEADSKLDKLEKKIITIDNLADYFYGYGEENSLPQVVFDLLKEKGKTITAAESLTAGLFQARLADFAGASDIFKGGFITYSIEEKARMLGIPFEDLQLHGVVSAFTAEKMAERSRQLTQADLAISLTGVAGPDSLEGQPAGTVFIGLSSSKRTMAIKVLIGGRSRSDVRYIAVLHAFNLVRQTLLSHKNLV","1955664","From GenBank (gi:1705867): In S.pneumoniae, this protein is induced by competence and damage.","competence damage-inducible protein A","Cytoplasm","Many strong matches in gapped BLAST to competence/damage-inducible protein CinA; e.g. residues 1-418 are 69% similar to competence-damage protein of Streptococcus pyogenes (gi15675867); residues 1-413 are 70% similar to CinA protein of Streptococcus pneumoniae (gi1705867).SMu1893 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001453
Domain

Molybdopterin binding domain
PD002460	$\"[3-96]T$	MoCF_biosynth
PF00994	$\"[4-171]T$	MoCF_biosynth
SSF53218	$\"[1-206]T$	MoCF_biosynth

InterPro
IPR008135
Family

Competence-damaged protein
PIRSF006728	$\"[1-416]T$	CinA
TIGR00200	$\"[1-414]T$	cinA_nterm

InterPro
IPR008136
Domain

CinA, C-terminal
PF02464	$\"[257-411]T$	CinA
TIGR00199	$\"[264-411]T$	cinA_cterm

noIPR
unintegrated

unintegrated
PD004924	$\"[277-384]T$	Cu-oxidase
G3DSA:3.40.980.10	$\"[3-169]T$	G3DSA:3.40.980.10
PTHR10192	$\"[3-93]T$	PTHR10192

","BeTs to 8 clades of COG1058COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1058 is a--ky-vcebr----------Number of proteins in this genome belonging to this COG is 1","***** IPB003396 (Competence-damaged protein) with a combined E-value of 5e-32. IPB003396A 275-307 IPB003396B 315-362","Residues 4-90 are 80% similar to a (BIOSYNTHESIS COFACTOR MOLYBDENUM PROTEOME COMPLETE) protein domain (PD002460) which is seen in CINA_STRPN.Residues 259-409 are 68% similar to a (COMPLETE PROTEOME CINA-LIKE CHE) protein domain (PD004924) which is seen in CINA_STRPN.Residues 115-197 are 51% similar to a (CINA-LIKE) protein domain (PD308534) which is seen in CINA_BACSU.Residues 198-257 are 58% similar to a (EXPORTED COMPETENCE-DAMAGE) protein domain (PD387107) which is seen in CINA_STRPN.Residues 115-230 are 31% similar to a (CINA-LIKE COMPETENCE-DAMAGE APE1980) protein domain (PD005383) which is seen in CINA_DEIRA.Residues 198-256 are 49% similar to a (PROTEOME COMPLETE CINA-LIKE INDUCIBLE) protein domain (PD412536) which is seen in Q9KAA5_BACHD.Residues 92-197 are 73% similar to a (PROTEOME COMPLETE COMPETENCE-DAMAGE) protein domain (PD407429) which is seen in CINA_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 17:36:49 2002","Wed Sep 20 14:31:12 2006","Wed Sep 20 14:31:12 2006","Thu Oct 10 17:36:49 2002","Sun Jan 6 12:09:26 2002","Sun Jan 6 12:09:26 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1893 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 12:26:15 2002","","No significant hits to the NCBI PDB database.","SMU.2086c","","Residues 1 to 137 (E-value = 1.1e-14) place SMu1893 in the MoCF_biosynth family which is described as Probable molybdopterin binding domain (PF00994)Residues 257 to 411 (E-value = 1.1e-69) place SMu1893 in the CinA family which is described as Competence-damaged protein (PF02464)","Wed Sep 20 14:31:12 2006","","","Martin,B., Garcia,P., Castanie,M.P. and Claverys,J.P. The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls lysogenic induction. Mol. Microbiol. 15 (2), 367-379 (1995) PubMed: 7538190.Pearce,B.J., Naughton,A.M., Campbell,E.A. and Masure,H.R. The rec locus, a competence-induced operon in Streptococcus pneumoniae. J. Bacteriol. 177 (1), 86-93 (1995) PubMed: 7798154.","","Sun Jan 6 12:26:15 2002","","1","","","SMU.2086c","495" "SMu1894","1957611","1957051","561","ATGAAGCGTTGCAGTTGGGTAAAAGAAAGCAATCCTTTGTATGTTGTTTATCATGATGAGGAATGGGGGAAGCCATTGCATGATGAGCAAAGATTATTCGAATTACTGTGTTTAGAAACTTATCAAGCTGGACTTTCTTGGGAAACTATTCTCAACAAACGTGAGGCTTTTAAATCTGTTTTTCATCATTATGAAATTGATAAAGTAGCTGCTATGTCTGATGAAGTATTGGAAGAGATTTTAAAAAATCCGAAGGTTGTTCGTAATCGCAGAAAAGTTTATGCAACACGTCATAACGCACAGGCGTTTTTAGCTATACAGAAAACATTTGGAAGTTTTGATCATTATCTTTGGTCTTGGGTGAACTTTACACCAATTGACAATTTTGTCAAGAATTGTCAAAGTATACCTGCTCAAACGAATTTATCAGAAAGGCTTGCTAAGGATTTAAAAAAGAAGGGTTTTAAATTTGTTGGTCCTGTTTGCATTTATTCTTATTTACAGGCAGCAGGTTTAATTAATGATCACGAAGTTAATTGTGATTTTAACCCTAAAAAATAA","8.30","4.45","21831","MKRCSWVKESNPLYVVYHDEEWGKPLHDEQRLFELLCLETYQAGLSWETILNKREAFKSVFHHYEIDKVAAMSDEVLEEILKNPKVVRNRRKVYATRHNAQAFLAIQKTFGSFDHYLWSWVNFTPIDNFVKNCQSIPAQTNLSERLAKDLKKKGFKFVGPVCIYSYLQAAGLINDHEVNCDFNPKK","1957069","From GenBank (gi:112785): In E. coli, this protein performs the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions. Its catalytic activity is the hydrolysis of alkylated DNA releaseing 3-methyladenine; it is controlled by product inhibition.","3-methyladenine DNA glycosylase I","Cytoplasm","Many matches in gapped BLAST to 3-Methyladenine DNA glycosylase I; e.g. residues 2-182 are 63% similar to 3-Methyladenine DNA glycosylase I, constitutive of Streptococcus pneumoniae (gi15902210); residues 1-183 are 57% similar to 3-Methyladenine DNA glycosylase I, constitutive of Streptococcus pyogenes (gi15675868).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2095 (4e-72).","

InterPro
IPR005019
Family

Methyladenine glycosylase
PF03352	$\"[6-185]T$	Adenine_glyco

InterPro
IPR011257
Domain

DNA glycosylase
SSF48150	$\"[1-185]T$	DNA_glycsylse

noIPR
unintegrated

unintegrated
G3DSA:1.10.340.30	$\"[1-183]T$	G3DSA:1.10.340.30

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 4-180 are 45% similar to a (DNA-3-METHYLADENINE GLYCOSIDASE PROTEOME) protein domain (PD013429) which is seen in O33438_PSEFL.Residues 143-180 are 52% similar to a (DNA-3-METHYLADENINE GLYCOSYLASE) protein domain (PD254850) which is seen in Q9LTW3_ARATH.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Fri May 10 17:09:45 2002","Thu Sep 21 08:28:12 2006","Thu Sep 21 08:28:12 2006","Sun Jan 6 11:23:52 2002","","Sun Jan 6 11:23:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1894 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 11:28:22 2002","","No significant hits to the NCBI PDB database.","SMU.2087c","","Residues 6 to 185 (E-value = 3.4e-93) place SMu1894 in the Adenine_glyco family which is described as Methyladenine glycosylase (PF03352)","Sun Jan 6 11:23:52 2002","","","","Sakumi,K., Nakabeppu,Y., Yamamoto,Y., Kawabata,S., Iwanaga,S. and Sekiguchi,M. Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli. J. Biol. Chem. 261 (33), 15761-15766 (1986) PubMed: 3536912.Steinum,A.L. and Seeberg,E. Nucleotide sequence of the tag gene from Escherichia coli. Nucleic Acids Res. 14 (9), 3763-3772 (1986) PubMed: 3520491.","","Sun Jan 6 11:31:59 2002","1","","","SMU.2087c","985" "SMu1895","1958286","1957693","594","ATGTACGATTATATTAAAGGGAATTTAACCAAAATTACAGCTAAATATATTGTCTTAGAAACTGGCGGTTTGGGTTATGTAATTAATGTTGCCAATCCTTATAGTTTTTCTAATCAGATAAATCAAGCTATTCAAATTTATATTCACCATGTTGTCCGTGAAGATGCCCATCTTCTTTATGGTTTTCATACTGAGGATGAAAAGGCGGTTTTTCTTAATCTTATCTCTGTTTCAGGAATCGGTCCAACTTCAGCATTAGCTATTATTGCGGCTGATGATAATGAAGGTTTGGTTAAAGCTATTGACCACAGTGATGTAAACTATTTGATGAAATTCCCTAAAATTGGGAAGAAAACAGCTCAACAAATGGTGCTTGATTTAGCAGGTAAATTTGTAGATATTAATGAAGTCTCAACCGATAAAAGCAAAGTGAGCACTATTAATAATAATCAAGAACTTGAAGAGGCGGTTGAAGCACTTTTGGCTCTTGGTTACAAAACAAATGAACTTAAGAAGATAGAAAAATTTTTTGAAGGAACGACTGATACGGCAGAAAATTATATTAAATCTGCTCTAAAAATGTTGATGAAATAG","5.70","-3.80","21881","MYDYIKGNLTKITAKYIVLETGGLGYVINVANPYSFSNQINQAIQIYIHHVVREDAHLLYGFHTEDEKAVFLNLISVSGIGPTSALAIIAADDNEGLVKAIDHSDVNYLMKFPKIGKKTAQQMVLDLAGKFVDINEVSTDKSKVSTINNNQELEEAVEALLALGYKTNELKKIEKFFEGTTDTAENYIKSALKMLMK","1957711","For other 'ruv' genes see SMu0058 (ruvB).From GenBank (gi:13878764): In Lactococcus lactis, the RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequences, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday Junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. RuvA forms a complex with RuvB and belongs to the RuvA family.For more information on the RuvABC operon, see a review: West,S.C. Processing of recombination intermediates by the RuvABC proteins. Annu. Rev. Genet. 31, 213-244 (1997) PubMed: 9442895.","Holliday junction DNA helicase","Cytoplasm","Numerous matches in gapped BLAST to Holiday junction DNA helicases; e.g. residues 1-197 are 68% similar to Holiday junction DNA helicase of Streptococcus pyogenes (gi15675869); residues 1-197 are 55% similar to DNA helicase RuvA of Lactococcus lactis (gi13878764).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2096 (7e-73).","

InterPro
IPR000085
Family

Bacterial DNA recombination protein RuvA
TIGR00084	$\"[1-197]T$	ruvA

InterPro
IPR003583
Domain

Helix-hairpin-helix DNA-binding, class 1
SM00278	$\"[72-91]T$ $\"[107-126]T$	HhH1

InterPro
IPR010994
Domain

RuvA domain 2-like
SSF47781	$\"[64-134]T$	RuvA_2_like

InterPro
IPR011114
Domain

RuvA, domain III
PF07499	$\"[151-196]T$	RuvA_C

InterPro
IPR011132
Domain

RuvA-like, C-terminal
SSF46929	$\"[149-196]T$	RuvA_C-like

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[1-65]T$	OB_NA_bd_sub

InterPro
IPR013849
Domain

Bacterial DNA recombination protein RuvA, domain I
PF01330	$\"[1-61]T$	RuvA_N

InterPro
IPR013850
Domain

Bacterial DNA recombination protein, RuvA, central
PD006268	$\"[71-133]T$	RuvA

noIPR
unintegrated

unintegrated
G3DSA:1.10.150.20	$\"[66-157]T$	G3DSA:1.10.150.20
SSF50249	$\"[1-62]T$	Nucleic_acid_OB

","BeTs to 11 clades of COG0632COG name: Holliday junction DNA helicase subunitFunctional Class: LThe phylogenetic pattern of COG0632 is ------vcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000085 (Bacterial DNA recombination protein, RuvA) with a combined E-value of 9.4e-45. IPB000085A 1-10 IPB000085B 46-87 IPB000085C 109-128 IPB000085D 155-165 IPB000085E 188-193","Residues 5-193 are 55% similar to a (DNA HELICASE HOLLIDAY JUNCTION) protein domain (PD006268) which is seen in RUVA_LACLA.Residues 14-133 are 27% similar to a (DNA HELICASE JUNCTION RECOMBINATION) protein domain (PD249938) which is seen in Q9PQ41_UREPA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Aug 21 16:59:30 2006","Mon Aug 21 16:59:30 2006","Mon Aug 21 16:59:30 2006","Wed Apr 3 15:03:50 2002","Sun Jan 6 11:07:41 2002","Sun Jan 6 11:07:41 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1895 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 11:21:21 2002","Mon Aug 21 16:59:30 2006","pdb1C7YA Chain A, E.Coli Ruva-Holliday Junction Complex >gi2... 96 4e-021pdb1CUK Escherichia Coli Ruva Protein At Ph 4.9 And Room T... 95 5e-021pdb1D8LA Chain A, E. Coli Holliday Junction Binding Protein R... 94 2e-020","SMU.2088c","","Residues 1 to 61 (E-value = 1.6e-26) place SMu1895 in the RuvA family which is described as RuvA N terminal domain (PF01330)","Sun Jan 6 11:07:41 2002","","","","Shinagawa,H., Makino,K., Amemura,M., Kimura,S., Iwasaki,H. and Nakata,A. Structure and regulation of the Escherichia coli ruv operon involved in DNA repair and recombination. J. Bacteriol. 170 (9), 4322-4329 (1988) PubMed: 2842314.Tsaneva,I.R., Muller,B. and West,S.C. RuvA and RuvB proteins of Escherichia coli exhibit DNA helicase activity in vitro. Proc. Natl. Acad. Sci. U.S.A. 90 (4), 1315-1319 (1993) PubMed: 8433990.Rafferty,J.B., Sedelnikova,S.E., Hargreaves,D., Artymiuk,P.J., Baker,P.J., Sharples,G.J., Mahdi,A.A., Lloyd,R.G. and Rice,D.W. Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction. Science 274 (5286), 415-421 (1996) PubMed: 8832889.West,S.C. Processing of recombination intermediates by the RuvABC proteins. Annu. Rev. Genet. 31, 213-244 (1997) PubMed: 9442895.","","Sun Jan 6 11:21:21 2002","1","","","SMU.2088c","739" "SMu1896","1960424","1958469","1956","ATGTCAAAAATTATTGAACTGCCAGAAGTTTTAGCCAATCAAATTGCTGCTGGAGAGGTTATTGAAAGACCAGCTAGTGTCGTAAAAGAACTAGTTGAGAATGCTATTGACGCTGATAGCAGCCAAATTACAATAGAAATTGAAGAATCAGGACTGAAAAAAATTCAAGTGACTGATAATGGTCAAGGAATAGAACAAGCGGATGTAATTATGAGCTTACGTCGCCATGCAACTAGTAAGATTAAAAAACAATCCGATCTTTTTAGAATTAGGACCTTAGGTTTTAGAGGTGAGGCCCTTCCATCAATTGCTTCTATTAGCAGATTAACATTAAAAACAGCAACAAAAGGGGAAATATATGGCACTTTATTAATCGCAAATGGAGGTAAAATTGAAAAAGAAGAAGCCATTAGTACCCCTATTGGAACCAAAGTGAGTGTTGAAAATCTTTTCTTCAATACCCCTGCTCGCCTTAAATATATGAAAAGTTTGCAGGCAGAGCTTGCTCATATTATTGATGTCATTAACCGTCTTAGCTTGGCGCATCCCGAAATTGCTTTCACGCTTATTAATGATGGCCGTGAATTAACAAAGACGGCAGGTAAAGGCGATCTGCGTCAAGCTTTAGCGGGTATTTATGGGGTAACCATTGCTAAAAAAATGGTCGAAATTTCAAATGCAGATCTTGATTTTGAGGTATCTGGTTATATTAGTTTGCCTGAATTAACCCGAGCTAATCGCAATTATATTACCATTCTTATTAATGGGCGTTATATCAAAAATTTTTTGCTCAATCGCGCTATTCTTGATGGTTATGGTTCAAAATTAATGGTGGGACGTTTTCCAATTGCTGTTATTGATATTCAGATTGACCCTTATTTAGCAGATGTTAATGTTCATCCAACTAAGCAGGAAGTTCGCATTTCTAAAGAAAAAGAGTTAATGAATCTCGTTAGTTCGGCAATTGCAGATAGTTTAAGAGAACAAGAGTTAATTCCTGATGCTTTGGAAAATCTTGCTAAAACTAGCACAAACAAGAAACAAAAGTTTGAACAAACACAGCTTCCTCTTAAACAATCAAATCTTTACTATGATAAGACTCAAAATGACTTCTTTCTCAAAGAAACGACAGTTTCAGAAGCATCAAGCGAGTTTACAGTAGTTGATAAAGCTGTAAATATTACTGATAATGTATCAGGACATAGTAGTGTAAAATATGCTCAACGTCAAATGAGAACTTGTGAAAACAAAGAGCATCCAAGTCTTACTATGACAGATAAGCAACAAAAGCGACAGCTTAGTAGAATTGTTGAAAGTCTAGAAAATGAAGAAAAGTCAACTTTTCCTGAGTTAGAATATTTTGGTCAAATGCATGGAACTTACCTCTTTGCTCAAGGTGAAGGGGGGCTTTATATTATAGATCAACATGCTGCTCAAGAACGTGTTAAATATGAATATTATCGTGATAAAATTGGAGAAGTAGACAATAGTTTACAGCAGCTTTTAGTACCTTATCTTTTTGAATTTCCTGCTAATGATTTTATGACCTTACAAGAAAAAATGAGCATTTTAAATGAGGTGGGAATTCACTTAGAAAACTATGGAGAGAATACTTTTATTTTGAGGGAACATCCTATTTGGTTACAGGAAAAAGAAATTGAATCAGCCGTTTATGAGATGTGTGACATGTTGCTGTTGACAAATGAAGTCTCCATTAAGAAATATCGAGCGGAATTAGCTATTATGATGTCTTGCAAGCGTTCTATCAAGGCTAATCATACTTTGGATGATTATTCTGCCAGAAATCTCTTAATTCAATTATCACAGTGCAAAAATCCTTACAATTGTCCTCATGGACGTCCTGTGCTTGTGAATTTCACAAAAGCTGATATGGAAAAGATGTTTCGTCGCATTCAGGAAAACCATACTAGTTTGAGAGAATTAGGGAAATACTGA","6.40","-5.02","73803","MSKIIELPEVLANQIAAGEVIERPASVVKELVENAIDADSSQITIEIEESGLKKIQVTDNGQGIEQADVIMSLRRHATSKIKKQSDLFRIRTLGFRGEALPSIASISRLTLKTATKGEIYGTLLIANGGKIEKEEAISTPIGTKVSVENLFFNTPARLKYMKSLQAELAHIIDVINRLSLAHPEIAFTLINDGRELTKTAGKGDLRQALAGIYGVTIAKKMVEISNADLDFEVSGYISLPELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMNLVSSAIADSLREQELIPDALENLAKTSTNKKQKFEQTQLPLKQSNLYYDKTQNDFFLKETTVSEASSEFTVVDKAVNITDNVSGHSSVKYAQRQMRTCENKEHPSLTMTDKQQKRQLSRIVESLENEEKSTFPELEYFGQMHGTYLFAQGEGGLYIIDQHAAQERVKYEYYRDKIGEVDNSLQQLLVPYLFEFPANDFMTLQEKMSILNEVGIHLENYGENTFILREHPIWLQEKEIESAVYEMCDMLLLTNEVSIKKYRAELAIMMSCKRSIKANHTLDDYSARNLLIQLSQCKNPYNCPHGRPVLVNFTKADMEKMFRRIQENHTSLRELGKY","1958487","From GenBank (gi:123083): In S.pneumoniae, HexB is involved in the repair of mismatches in DNA. It is nick-directed and belongs to the MutL/HexB family.From Medline(90008767): The Hex mismatch repair system of Streptococcus pneumoniae acts both during transformation (a recombination process that directly produces heteroduplex DNA) to correct donor strands and after DNA replication to remove misincorporated nucleotides. The hexB gene product is one of at least two proteins required for mismatch repair in this organism. The HexB protein is homologous to the MutL protein, which is required for methyl-directed mismatch repair in Salmonella typhimurium and Escherichia coli. The conservation of HexB-like proteins among procaryotic and eucaryotic organisms indicates that these proteins play an important common role in the repair process.See HexA, SMu1898.","DNA mismatch repair protein","Cytoplasm","Numerous strong matches in gapped BLAST to DNA mismatch repair protein, HexB; e.g. residues 1-651 are 69% similar to DNA mismatch repair protein hexB of Streptococcus pneumoniae (gi123083); residues 1-644 are 59% similar to DNA mismatch repair protein MutL of Lactococcus lactis (gi15674190).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2098 (0.0).","

InterPro
IPR002099
Family

DNA mismatch repair protein
PTHR10073	$\"[65-639]T$	DNA_mis_repair

InterPro
IPR003594
Domain

ATP-binding region, ATPase-like
G3DSA:3.30.565.10	$\"[3-216]T$	ATP_bd_ATPase
PF02518	$\"[19-69]T$	HATPase_c
SM00387	$\"[19-115]T$	HATPase_c
SSF55874	$\"[1-214]T$	ATP_bd_ATPase

InterPro
IPR013507
Domain

DNA mismatch repair protein, C-terminal
PF01119	$\"[214-327]T$	DNA_mis_repair

InterPro
IPR014762
Domain

DNA mismatch repair, MutL/HexB/PMS1
PS00058	$\"[94-100]?$	DNA_MISMATCH_REPAIR_1

InterPro
IPR014763
Domain

DNA mismatch repair protein, N-terminal
TIGR00585	$\"[2-307]T$	mutl

InterPro
IPR014790
Domain

MutL, C-terminal, dimerisation
PF08676	$\"[453-595]T$	MutL_C

noIPR
unintegrated

unintegrated
PTHR10073:SF12	$\"[65-639]T$	PTHR10073:SF12
SSF54211	$\"[190-328]T$	SSF54211

","BeTs to 10 clades of COG0323COG name: DNA mismatch repair enzyme (predicted ATPase)Functional Class: LThe phylogenetic pattern of COG0323 is ----Yqvceb-h----olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002099 (DNA mismatch repair proteins mutL/hexB/PMS1) with a combined E-value of 2.5e-79. IPB002099A 4-51 IPB002099B 61-108 IPB002099C 142-159 IPB002099D 250-262 IPB002099E 295-306 IPB002099F 616-623","Residues 4-318 are 77% similar to a (REPAIR DNA MISMATCH HOMOLOG) protein domain (PD002741) which is seen in HEXB_STRPN.Residues 583-637 are 36% similar to a (REPAIR DNA MISMATCH) protein domain (PD407510) which is seen in MUTL_SYNY3.Residues 576-637 are 87% similar to a (REPAIR DNA MISMATCH PROTEOME) protein domain (PD004905) which is seen in HEXB_STRPN.Residues 455-553 are 73% similar to a (REPAIR DNA MISMATCH PROTEOME) protein domain (PD018169) which is seen in HEXB_STRPN.Residues 486-574 are 57% similar to a (PROTEOME COMPLETE MISMATCH REPAIR) protein domain (PD414189) which is seen in Q9CDL1_LACLA.Residues 319-445 are 29% similar to a (PROTEOME COMPLETE MISMATCH REPAIR) protein domain (PD397262) which is seen in Q9CDL1_LACLA.Residues 319-454 are 36% similar to a (REPAIR DNA MISMATCH HEXB) protein domain (PD397314) which is seen in HEXB_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 17:34:28 2002","Thu Aug 24 11:05:47 2006","Thu Aug 24 11:05:47 2006","Thu Oct 10 17:34:28 2002","Sun Jan 6 10:58:15 2002","Sun Jan 6 10:58:15 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1896 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 10:59:04 2002","Thu Aug 24 11:05:47 2006","pdb1BKNA Chain A, Crystal Structure Of An N-Terminal 40kd Fra... 218 1e-057pdb1B62A Chain A, Mutl Complexed With Adp 218 1e-057pdb1B63A Chain A, Mutl Complexed With Adpnp 215 2e-056","SMU.2089c","","Residues 214 to 327 (E-value = 6.3e-41) place SMu1896 in the DNA_mis_repair family which is described as DNA mismatch repair protein, C-terminal domain (PF01119)","Sun Jan 6 10:58:15 2002","","","Prudhomme,M., Martin,B., Mejean,V. and Claverys,J.P. Nucleotide sequence of the Streptococcus pneumoniae hexB mismatch repair gene: homology of HexB to MutL of Salmonella typhimurium and to PMS1 of Saccharomyces cerevisiae. J. Bacteriol. 171 (10), 5332-5338 (1989) PubMed: 2676973.Whatmore,A.M., Efstratiou,A., Pickerill,A.P., Broughton,K., Woodard,G., Sturgeon,D., George,R. and Dowson,C.G. Genetic relationships between clinical isolates of Streptococcus pneumoniae, Streptococcus oralis, and Streptococcus mitis: characterization of 'Atypical' pneumococci and organisms allied to S. mitis harboring S. pneumoniae virulence factor-encoding genes. Infect. Immun. 68 (3), 1374-1382 (2000) PubMed: 10678950.","","Thu Aug 24 11:05:47 2006","","1","","","SMU.2089c","199" "SMu1897","1960888","1960736","153","GTGACAGTCAAAAGAGGACCTCTTAGTCTTCTCTTTTGTGATGTTCAAAATGAGGAAAATTCGTTTTTTAAAATTGTCCAAGTTCCTAAATCCAAAGGCATTGGCTTTGATATCTTTGATGAGCTTGTTGGTTGCTTCAAGTCTGGCATTTGA","6.40","-0.11","5533","MTVKRGPLSLLFCDVQNEENSFFKIVQVPKSKGIGFDIFDELVGCFKSGI","1960754","","hypothetical protein","Cytoplasm","No significant matches using gapped BLAST.SMu1897 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-3]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:06:19 2002","Sun Jan 6 10:43:07 2002","Sun Jan 6 10:43:07 2002","Sun Jan 6 10:43:07 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1897 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:06:19 2002","","No significant hits to the NCBI PDB database.","SMU.2090c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 10:43:07 2002","24380424","","","","","","1","","","SMU.2090c","" "SMu1898","1963471","1960922","2550","ATGACTAAGGAAAAACTCTCTCCAGGAATGCAGCAGTATTTGGATATCAAAAAAGACTATCCAGATGCTTTTTTGCTTTTCCGCATGGGAGACTTTTATGAACTATTTTATGATGATGCTATCAAGGCCGCTCAAATTTTAGAAATTAGCTTAACAAGTCGTAATAAAAATGCTGACAATCCTATTCCGATGGCTGGTGTCCCTTATCATTCAGCTCAACAGTATATTGATGTTTTGATTGATTTGGGTTATAAGGTTGCCATTGCTGAGCAGATGGAAGACCCTAAAAAAGCTGTTGGCGTTGTCAAACGTGAAGTGGTTCAAGTGATTACCCCGGGTACTGTTGTTGATTCAACTAAGCCAGACAGTGCTAATAATTTTTTAGTCTCTCTGGATACTGATGGCAGTCAGTTTGGCCTTTCTTACATGGATTTATCTACTGGGGAATTTTATGCGACAACATTAGCAGATTTGCCAGCAGTGAGAAGCGAAGTCCTCAATCTCAAGACGCGTGAATTAGTTATTGGTTTTGAACTGAGTGAGAATGAAGATCAGCTTTTTCGTAAGCAGATGAACCTGCTCTTATCTTTTGAAAAAACTGTCTATGACGATGTACATTTATTGGATGATCAATTAAAAGCAATAGAACTTGCTGCAGCTGGCAAACTCTTGCAATATGTTCATAACACACAAAAACGTGAGTTGAGTCATTTGCAAAAGTTGGTGCATTATGAAATCAAAGATTACTTGCAGATGGCTTATGCTACAAAATCTAGCTTGGATCTGTTAGAAAATGCCAGAAGCGGGAAAAAACACGGCAGTCTCTACTGGCTTTTAGATGAGACAAAAACAGCTATGGGGACACGTCTTTTGCGAACTTGGATTGATCGTCCTTTGGTCAGTTCAAGCCTTATCAGTAAACGTCAAGATATTATTCAGACTTTTCTAGATCACTTTTTTGAGCGCAGTGATCTTAGTGACAGCCTAAAAGGTGTTTATGATATTGAACGTTTGGCCAGCCGTGTTTCATTTGGGAAGGCCAATCCTAAGGATTTATTGCAATTGGGTCAGACCTTAAGTCAAGTTCCTGTCATTAAGACTATTCTTGAAAGTTTTGCCAGTTCTAGTTTGGAAAGCCTAATTAATCAAATTGATACTCTTCCAGAATTGGAAGCATTGATTCGTTCGGCTATTGACTCTAATGCACCTATAACTATTACAGAAGGCGGTATGATTCGAGAGGGGTTTGATGAAACTTTAGATAAGTATCGAACGGTAATGCGCGAAGGGACGAGTTGGATTGCTGACATTGAGACTAAGGAACGTCAGAAAAGCGGCATCTCAACCTTGAAGATTGATTATAACAAAAAAGACGGTTATTATTTCCATGTCACCAACTCTAATTTGTCTTTAGTACCAGATTACTTCTTTAGAAAGGCAACGCTTAAAAATTCTGAGCGCTTTGGGACAGCAGAGCTTGCAAAAATTGAAGGTGAAATGTTAGAAGCGCGTGAAGAATCAGCCAATTTAGAATATGATATTTTCATGCGTATCAGATCACAGGTTGAATCTTATATTGAGCGTCTTCAAAATCTGGCCAAGAGTCTAGCAACTGTTGATGTTTTGCAAAGTTTAGCAGTAGTAGCTGAGAATAATCATTATGTCAGACCTTCTTTTAATCATCAGCAGGAAATCAGTATTGAAAATGGTCGCCATGCTGTTGTTGAGAAGGTTATGGGAAGCCAAGAATATATTCCCAATACTATCAATTTTGACCAAAAGACTAGTATTCAACTGATTACTGGACCTAATATGAGCGGTAAGTCAACTTACATGCGGCAATTAGCTCTGACAGTTATTATGGCTCAATTAGGTTCTTTTGTAGCAGCTGATTCAGCTGATTTGCCGATTTTTGATGCTATTTTTACACGTATTGGTGCTGCAGATGATTTAATTTCAGGGCAGTCTACCTTTATGGTAGAGATGATGGAAGCCAATCATGCTATCAAGGCAGCGACACCTAATTCACTCATTTTATTTGATGAATTAGGACGTGGTACAGCAACTTATGATGGTATGGCTTTAGCACAGGCTATTATTGAGTATATTCATAATAAAGTTGGAGCTAAAACGCTATTTGCTACCCATTATCATGAGTTGACAGACTTGTCAACTAGATTGACAAGTCTTGTCAATGTACATGTTGCTACTCTTGAAAAAGATGGAGAGGTCACTTTTCTTCATAAAATTGCTGATGGACCAGCTGATAAATCTTATGGAATCCATGTTGCTAAAATTGCCGGCTTGCCTAAAGATTTACTTAATCGAGCTGATCACATATTAGTTGATTTAGAAAAAATGAGTGCAGCTGTCTCAGTCAATCTAAAAAACGAGACCAAAGAAAGCCAACCTGTGGAAGAGCAGTTGTCACTTTTTGCTATTGATAATAATTATGAAGAATTAATCAAAAAATTGAAACAGTTGGACCTTACCAATTTAACACCAAGAGAATCCATGAATGCCTTATTTGATTTGAAGGAACTATTATAA","5.10","-25.32","95336","MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIDLGYKVAIAEQMEDPKKAVGVVKREVVQVITPGTVVDSTKPDSANNFLVSLDTDGSQFGLSYMDLSTGEFYATTLADLPAVRSEVLNLKTRELVIGFELSENEDQLFRKQMNLLLSFEKTVYDDVHLLDDQLKAIELAAAGKLLQYVHNTQKRELSHLQKLVHYEIKDYLQMAYATKSSLDLLENARSGKKHGSLYWLLDETKTAMGTRLLRTWIDRPLVSSSLISKRQDIIQTFLDHFFERSDLSDSLKGVYDIERLASRVSFGKANPKDLLQLGQTLSQVPVIKTILESFASSSLESLINQIDTLPELEALIRSAIDSNAPITITEGGMIREGFDETLDKYRTVMREGTSWIADIETKERQKSGISTLKIDYNKKDGYYFHVTNSNLSLVPDYFFRKATLKNSERFGTAELAKIEGEMLEAREESANLEYDIFMRIRSQVESYIERLQNLAKSLATVDVLQSLAVVAENNHYVRPSFNHQQEISIENGRHAVVEKVMGSQEYIPNTINFDQKTSIQLITGPNMSGKSTYMRQLALTVIMAQLGSFVAADSADLPIFDAIFTRIGAADDLISGQSTFMVEMMEANHAIKAATPNSLILFDELGRGTATYDGMALAQAIIEYIHNKVGAKTLFATHYHELTDLSTRLTSLVNVHVATLEKDGEVTFLHKIADGPADKSYGIHVAKIAGLPKDLLNRADHILVDLEKMSAAVSVNLKNETKESQPVEEQLSLFAIDNNYEELIKKLKQLDLTNLTPRESMNALFDLKELL","1960940","From GenBank (gi:123080): In S.pneumoniae, this protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity and belongs to the DNA mismatch repair MutS family.From Medline (88086867): The Hex system of heteroduplex DNA base mismatch repair operates in Streptococcus pneumoniae after transformation and replication to correct donor and nascent DNA strands, respectively. A functionally similar system, called Mut, operates in Escherichia coli and Salmonella typhimurium. Only HexA functioned in mismatch repair and the promoter for hexA transcription was located within the OrfC-coding region. The HexA polypeptide contains a consensus sequence for ATP- or GTP-binding sites in proteins. Comparison of the entire HexA protein sequence to that of MutS of S. typhimurium, which was determined by Haber et al. in the accompanying paper (L. T. Haber, P. P. Pang, D. I. Sobell, J. A. Mankovitch, and G. C. Walker, J. Bacteriol. 170:197-202, 1988), showed the proteins to be homologous, inasmuch as 36% of their amino acid residues were identical. This homology indicates that the Hex and Mut systems of mismatch repair evolved from an ancestor common to the gram-positive streptococci and the gram-negative enterobacteria.See HexB, SMu1896.","DNA mismatch repair protein, HexA","Cytoplasm","Numerous strong matches in gapped BLAST to DNA mismatch repair protein HexA; e.g. residues 1-849 are 71% similar to DNA mismatch repair protein HexA of Streptococcus pneumoniae (gi|123080); residues 7-849 are 48% similar to DNA mismatch repair protein MutS of Bacillus subtilis (gi|7404403).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2101 (0.0).","

InterPro
IPR000432
Domain

DNA mismatch repair protein MutS, C-terminal
PD001263	$\"[645-753]T$	MutS_C
PF00488	$\"[554-787]T$	MutS_V
SM00534	$\"[595-782]T$	MUTSac
PS00486	$\"[676-692]T$	DNA_MISMATCH_REPAIR_2

InterPro
IPR005748
Family

MutS 1 protein
TIGR01070	$\"[6-847]T$	mutS1

InterPro
IPR007695
Domain

DNA mismatch repair protein MutS, N-terminal
PF01624	$\"[7-119]T$	MutS_I

InterPro
IPR007696
Domain

MutS III
PF05192	$\"[247-551]T$	MutS_III
SM00533	$\"[270-578]T$	MUTSd

InterPro
IPR007860
Domain

MutS II
PF05188	$\"[126-239]T$	MutS_II

InterPro
IPR007861
Domain

MutS IV
PF05190	$\"[415-506]T$	MutS_IV

noIPR
unintegrated

unintegrated
G3DSA:1.10.1420.10	$\"[247-436]T$	G3DSA:1.10.1420.10
G3DSA:3.30.420.110	$\"[126-244]T$	G3DSA:3.30.420.110
G3DSA:3.40.1170.10	$\"[4-112]T$	G3DSA:3.40.1170.10
G3DSA:3.40.50.300	$\"[554-787]T$	G3DSA:3.40.50.300
PTHR11361	$\"[600-808]T$	PTHR11361
PTHR11361:SF34	$\"[600-808]T$	PTHR11361:SF34
SSF48334	$\"[253-553]T$	SSF48334
SSF52540	$\"[554-788]T$	SSF52540
SSF53150	$\"[115-266]T$	SSF53150
SSF55271	$\"[2-112]T$	SSF55271

","BeTs to 10 clades of COG0249COG name: MutS-like ATPases involved in mismatch repair, family 2Functional Class: LThe phylogenetic pattern of COG0249 is ----Yqvceb-h----olinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000432 (DNA mismatch repair protein MutS family, C-terminal domain) with a combined E-value of 5.3e-98. IPB000432A 30-40 IPB000432B 287-308 IPB000432C 599-630 IPB000432D 639-687 IPB000432E 711-721 IPB000432F 746-777","Residues 536-777 are 79% similar to a (REPAIR DNA MISMATCH ATP-BINDING) protein domain (PD001263) which is seen in HEXA_STRPN.Residues 193-323 are 66% similar to a (REPAIR DNA MISMATCH DNA-BINDING) protein domain (PD002590) which is seen in HEXA_STRPN.Residues 5-40 are 94% similar to a (REPAIR DNA MISMATCH ATP-BINDING) protein domain (PD405064) which is seen in MUTS_LACLA.Residues 324-530 are 72% similar to a (REPAIR DNA MISMATCH ATP-BINDING) protein domain (PD188480) which is seen in HEXA_STRPN.Residues 43-192 are 78% similar to a (REPAIR DNA MISMATCH ATP-BINDING) protein domain (PD136848) which is seen in HEXA_STRPN.Residues 6-54 are 51% similar to a (PROTEOME COMPLETE MISMATCH REPAIR) protein domain (PD388263) which is seen in Q9HSL6_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 14:16:01 2002","Sun Jan 6 10:41:59 2002","Thu Oct 10 17:33:50 2002","Mon Apr 15 14:16:01 2002","Sun Jan 6 10:41:59 2002","Sun Jan 6 10:41:59 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1898 is paralogously related (blast p-value < 1e-3) to SMu1700, a predicted DNA mismatch repair protein MutS2.","Mon Apr 15 14:16:01 2002","Sun Jan 6 10:41:59 2002","pdb|1E3M|A Chain A, The Crystal Structure Of E. Coli Muts Bindi... 511 1e-145pdb|1EWQ|A Chain A, Crystal Structure Taq Muts Complexed With A... 499 5e-142pdb|1EWR|A Chain A, Crystal Structure Of Taq Muts >gi|11514362|... 416 5e-117","SMU.2091c","","Residues 7 to 119 (E-value = 1.4e-71) place SMu1898 in the MutS_I family which is described as MutS domain I (PF01624)Residues 126 to 239 (E-value = 1.1e-24) place SMu1898 in the MutS_II family which is described as MutS domain II (PF05188)Residues 247 to 551 (E-value = 3.7e-138) place SMu1898 in the MutS_III family which is described as MutS domain III (PF05192)Residues 415 to 506 (E-value = 8.1e-39) place SMu1898 in the MutS_IV family which is described as MutS family domain IV (PF05190)Residues 554 to 787 (E-value = 7.5e-150) place SMu1898 in the MutS_V family which is described as MutS domain V (PF00488)","Sun Jan 6 10:41:59 2002","24380425","","Priebe,S.D., Hadi,S.M., Greenberg,B. and Lacks,S.A. Nucleotide sequence of the hexA gene for DNA mismatch repair in Streptococcus pneumoniae and homology of hexA to mutS of Escherichia coli and Salmonella typhimurium. J. Bacteriol. 170 (1), 190-196 (1988) PubMed: 3275608.","Ginetti,F., Perego,M., Albertini,A.M. and Galizzi,A. Bacillus subtilis mutS mutL operon: identification, nucleotide sequence and mutagenesis. Microbiology 142 (Pt 8), 2021-2029 (1996) PubMed: 8760914.","Sun Jan 6 10:41:59 2002","Sun Jan 6 10:41:59 2002","1","","","SMU.2091c","200" "SMu1899","1963811","1963464","348","ATGAGCCCATTTGAAGAAGCCTTAAATCAGTTAATAGAGCTTTTGCAGGAACATGACAGTGTGCAAGCTTTTCAAGCTGTTGAAAAAAAGATTAAAGCCTTACCGGAGTTAAAGAAAGTAGCACATGATATGAAAGGCTATCAACAAGACGCTGTTCTTTTTCAAAGGATTGAAAAAAGTAAAGCTCAAAAAGAAGCTGATCAAAAGGCGCAAAAAATGGGAGAGAGTTTGGATAAGCTTCCCATTGTCCAAGATTATCGAGCCAAAATGCAGGATGCCAGCGATCTTTTACAATATGTAACCAAGACTCTAGAAGAGAAAATAAATGAGGAGTTAGGAAATGACTAA","4.90","-4.52","13203","MSPFEEALNQLIELLQEHDSVQAFQAVEKKIKALPELKKVAHDMKGYQQDAVLFQRIEKSKAQKEADQKAQKMGESLDKLPIVQDYRAKMQDASDLLQYVTKTLEEKINEELGND","1963482","","conserved hypothetical protein","Cytoplasm","One weak match in gapped BLAST to an unknown protein of Lactococcus lactis; e.g. residues 4-109 are 33% similar to this protein in L.lactis (gi|15674193).SMu1899 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 11-109 are 35% similar to a (PROTEOME COMPLETE BH2371 YMCA) protein domain (PD407390) which is seen in Q9CDK8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:05:22 2002","Sun Jan 6 10:26:57 2002","Sun Jan 6 10:26:57 2002","Sun Jan 6 10:26:57 2002","","Sun Jan 6 10:26:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1899 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:05:22 2002","","No significant hits to the NCBI PDB database.","SMU.2092c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 10:26:57 2002","24380426","","","","","","1","","","SMU.2092c","" "SMu1900","1964245","1963808","438","ATGAATAAATTATCACGTCAAAACAAAATAAAACAAATCATACGCTCAAAACATATAGGTACTCAAGAAGAATTGAAGCATCAACTTGAATTAGAAAAAGTTTTTGTTACTCAGGCGACATTATCACGAGATATGCGAGAATTAGGTCTTTTTAAATCACGTGATAAAGAAGGATACCTATATTATGAAATACCAGAAAATGGTTCGACTATTTTTACGCCTGCTGCGCTTTATTATATTAAGAAGGTTTTCCGAACAGATGCGCTTTTAGTTTTTCATACCAATTTGGGAGAGGCAGATGTTTTGGCAAATTTGATTGATTCGGAGTCTCATTCTGAAATTCTTGGAACTGTTGCTGGTGCAGATACCCTTTTGGTTATTTGTAAAAATGAAGAAATTGCCAGCCAGTTAGAAAGCGATGTTCTTTCAAACTTATGA","5.70","-3.08","16398","MNKLSRQNKIKQIIRSKHIGTQEELKHQLELEKVFVTQATLSRDMRELGLFKSRDKEGYLYYEIPENGSTIFTPAALYYIKKVFRTDALLVFHTNLGEADVLANLIDSESHSEILGTVAGADTLLVICKNEEIASQLESDVLSNL","1963826","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0607 (argB);SMu0608 (argD); SMu1904 (argS);SMu1903 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH).From GenBank (gi:3913094): In S.pneumoniae, this protein regulates arginine biosynthesis genes. It is cytoplasmic and belongs to the ArgR family.","arginine repressor","Cytoplasm","Some moderate matches in gapped BLAST to arginine repressors; e.g. residues 1-145 are 54% similar to arginine repressor of Streptococcus pyogenes (gi15675892); residues 1-141 are 42% similar to arginine repressor of Lactococcus lactis (gi15674021).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2102 (4e-35).","

InterPro
IPR001669
Family

Arginine repressor
PD007402	$\"[83-123]T$	Arg_repress
PR01467	$\"[21-34]T$ $\"[37-52]T$ $\"[84-97]T$ $\"[114-129]T$	ARGREPRESSOR
PF01316	$\"[1-70]T$	Arg_repressor
PF02863	$\"[87-144]T$	Arg_repressor_C
TIGR01529	$\"[4-145]T$	argR_whole
SSF55252	$\"[75-145]T$	Arg_repress

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[1-67]T$	Wing_hlx_DNA_bd

noIPR
unintegrated

unintegrated
G3DSA:3.30.1360.40	$\"[75-145]T$	G3DSA:3.30.1360.40
SSF46785	$\"[3-78]T$	SSF46785

InterPro
IPR000595
Domain

Cyclic nucleotide-binding
PF00027	$\"[34-124]T$	cNMP_binding
SM00100	$\"[10-137]T$	cNMP
PS50042	$\"[16-119]T$	CNMP_BINDING_3
SSF51206	$\"[33-150]T$	cNMP_binding

InterPro
IPR014710
Domain

RmlC-like jelly roll fold
G3DSA:2.60.120.10	$\"[11-150]T$	RmlC-like_jellyroll

","BeTs to 6 clades of COG0664COG name: cAMP-binding domains - Catabolite gene activator and regulatory subunit of cAMP-dependent protein kinasesFunctional Class: TThe phylogenetic pattern of COG0664 is a---YQvCEbRH-----Lin-Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 35-116 are 45% similar to a (REGULATION TRANSCRIPTION DNA-BINDING) protein domain (PD080629) which is seen in Q9K5F3_BACLI.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Apr 5 11:38:30 2007","Thu Apr 5 11:38:30 2007","Thu Apr 5 11:38:30 2007","Thu Apr 4 14:42:31 2002","","Sun Jan 6 10:03:52 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1901 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 10:12:18 2002","","No significant hits to the NCBI PDB database.","SMU.2094c","","Residues 31 to 124 (E-value = 2.8e-06) place SMu1901 in the cNMP_binding family which is described as Cyclic nucleotide-binding domain (PF00027)","Sun Jan 6 10:03:52 2002","24380428","","","Marina,A., Uriarte,M., Barcelona,B., Fresquet,V., Cervera,J. and Rubio,V. Carbamate kinase from Enterococcus faecalis and Enterococcus faecium--cloning of the genes, studies on the enzyme expressed in Escherichia coli, and sequence similarity with N-acetyl-L-glutamate kinase. Eur. J. Biochem. 253 (1), 280-291 (1998) PubMed: 9578487.Barcelona-Andres,B., Marina,A. and Rubio,V. The Arginine Deiminase Pathway in Enterococcus faecalis: Genes, Genes Products and Transcripts. Unpublished.","","Sun Jan 6 10:03:52 2002","1","","","SMU.2094c","" "SMu1902","1965864","1965640","225","TTGTTTCCACAAGCTAAAATTGGTATTGTCTTATTAAAAAAATTTCAATCTCAGAAACGATCACCAAAACCTATTATTGAATTACTTAAGAAAAGCAATGAGCTGGCTAAGACTTACCTCGTTGAAGATAACTTTAGTGATAATGCAGAAATACAAGTTCATAGAAAAGCTTATCAAAGATTTAAAACTAAAAAAGAGCATGTTCGAGTATTGAAGCATTACTAA","10.90","10.70","8790","MFPQAKIGIVLLKKFQSQKRSPKPIIELLKKSNELAKTYLVEDNFSDNAEIQVHRKAYQRFKTKKEHVRVLKHY","1965658","","conserved hypothetical protein","Cytoplasm, Periplasm","Few matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-65 are 63% similar to conserved protein of Streptococcus pyogenes (gi|15675447); residues 1-65 are 47% similar to unknown protein of Lactococcus lactis (gi|15674160).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2162 (1e-13).","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-65 are 47% similar to a (PROTEOME COMPLETE PA4181 APE1797) protein domain (PD339814) which is seen in Q9CDP1_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:03:13 2002","Sun Jan 6 09:53:03 2002","Sun Jan 6 09:53:03 2002","Sun Jan 6 09:53:03 2002","","Sun Jan 6 09:53:03 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1902 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 14:03:13 2002","","No significant hits to the NCBI PDB database.","SMU.2096c","","No significant hits to the Pfam 11.0 database","Sun Jan 6 09:53:03 2002","24380429","","","","","","1","","","SMU.2096c","" "SMu1903","1966306","1966542","237","ATGGAAGATGCTTTAGTTATGTTAAAGCCTGTCCAAAACCAAGTGATATTGAAAACACTGCCGGGTCTAGCCCAATCATTTGGCTCAATACTAGATTCCATGCAGTTAGTTGAAATTACAGCAACAGTTTGTGGTGATGATACCTGTCTTATTATTTGTAAAGATAAGGAAACAGCACTTAAATGTTTTGACCATCTATGCCAGTATACTCCTCCGTTCTTTTTCAGCAATGAATAA","4.30","-5.01","8655","MEDALVMLKPVQNQVILKTLPGLAQSFGSILDSMQLVEITATVCGDDTCLIICKDKETALKCFDHLCQYTPPFFFSNE","1966554","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0607 (argB);SMu0608 (argD); SMu1904 (argS);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH).From GenBank (gi:113535): In B.subtilis, arginine repressor represses the synthesis of biosynthetic enzymes and activates the arginine catabolism. It controls the transcription of the two operons, RocABC and RocDEF. This cytoplasmic homohexamer belongs to the ArgR family.From GenBank (gi:8134308): In Bacillus licheniformis, argR regulates arginine biosynthesis genes and activates arginine deiminase pathway genes. It is cytoplasmic and belongs to teh ArgR family.","arginine transcriptional repressor (arginine hydroxymate resistance protein)","Cytoplasm","Few moderate matches in gapped BLAST to arginine transcriptional repressor; e.g. residues 1-78 are 75% similar to arginine transcriptional repressor of Streptococcus pyogenes (gi|15675446); residues 3-57 are 43% similar to arginine repressor of Bacillus subtilis (gi|80357).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2160 (7e-32).","

InterPro
IPR001669
Family

Arginine repressor
PD007402	$\"[11-48]T$	Arg_repress
PR01467	$\"[9-22]T$ $\"[39-54]T$	ARGREPRESSOR
PF02863	$\"[1-69]T$	Arg_repressor_C
SSF55252	$\"[1-70]T$	Arg_repress

noIPR
unintegrated

unintegrated
G3DSA:3.30.1360.40	$\"[1-70]T$	G3DSA:3.30.1360.40

","BeTs to 5 clades of COG1438COG name: Arginine repressorFunctional Class: EThe phylogenetic pattern of COG1438 is ------v-ebrh-------n-Number of proteins in this genome belonging to this COG is 3","***** PR01467 (Bacterial arginine repressor signature) with a combined E-value of 9.5e-09. PR01467C 9-22 PR01467D 39-54","Residues 3-61 are 52% similar to a (REPRESSOR ARGININE TRANSCRIPTION) protein domain (PD007402) which is seen in Q9ZEV1_BACST.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 10:46:28 2002","Sun Jan 6 09:45:29 2002","Mon Oct 21 13:50:07 2002","Wed Apr 3 09:28:03 2002","Sun Jan 6 09:37:05 2002","Sun Jan 6 09:37:05 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1903 is paralogously related (blast p-value < 1e-3) to SMu1900, a predicted arginine repressor (arginine catabolic regulator).","Mon Apr 15 14:24:53 2002","Sun Jan 6 09:37:05 2002","pdb|1B4B|A Chain A, Structure Of The Oligomerization Domain Of ... 62 2e-011pdb|1B4A|A Chain A, Structure Of The Arginine Repressor From Ba... 62 2e-011","SMU.2097","","Residues 1 to 69 (E-value = 1e-08) place SMu1903 in the Arg_repressor_C family which is described as Arginine repressor, C-terminal domain (PF02863)","Sun Jan 6 09:37:05 2002","24380430","","","North,A.K., Smith,M.C. and Baumberg,S. Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor. Gene 80 (1), 29-38 (1989) PubMed: 2507400.Czaplewski,L.G., North,A.K., Smith,M.C., Baumberg,S. and Stockley,P.G. Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis. Mol. Microbiol. 6 (2), 267-275 (1992) PubMed: 1312212.Maghnouj,A., de Sousa Cabral,T.F., Stalon,V. and Vander Wauven,C. The arcABDC gene cluster, encoding the arginine deiminase pathway of Bacillus licheniformis, and its activation by the arginine repressor argR. J. Bacteriol. 180 (24), 6468-6475 (1998) PubMed: 9851988","","Sun Jan 6 09:45:29 2002","1","","","SMU.2097","" "SMu1904","1966643","1968334","1692","ATGAATCATAACAGATTAATTGCAAAAGAAATTGCAGCAATCGTTCCTGCTTTAGAGCAGGAAACTATTTTAAATTTACTGGAAAAACCCAAGAAATCTAGTATGGGAGATTTAGCTTTTCCAACATTTAGTTTAGCTAAAACGATGCGCAAAGCTCCGCAAATCATTGCCAGTGAACTTGTCGGTCAAATTAATAATAGCTATTTTGAGAAGGTCGAAGCTGTCGGCCCTTATATTAATTTTTTTCTTAATAAGTCAGAAATTTCAGCTCAAGTATTAAAAGAAGTCATTAAAAAAAGGGAAGATTACGCTCAAGCAGCCATTGGTCAAGGCCACAATATTGTTATTGATCTTTCTAGTCCTAATATTGCTAAACCTTTTTCTATTGGACATCTACGCTCCACTGTTATCGGCGATGCTTTATCTAATATTTTCCAAAAATTAGGCTATGAGACCGTTAAAATCAATCATTTAGGTGACTGGGGCAAACAGTTTGGCATGCTTATTGTTGCCTATAAAAAATGGGGCAGTGAAGAAGCAGTTAGAGCCCATCCTATTGATGAACTTTTAAAGATCTATGTTCGGATTAATGCTGAAACTAAAAACCATCCAGAACTTGATGAAGAAGCCCGCGAATGGTTCCGTAAACTCGAAAACAATGATGAGGAAGCCCTTGCACTTTGGCAATGGTTCCGCGATGAAAGCTTAATGGAATTCAATCGTCTTTATGCTGAGCTTGGTATAGATTTTGATAGCTACAATGGTGAAGCTTTTTACAATGATAAAATGGAAGAGGTTGTCCAATTACTAGCCGAGAAGGGACTTTTAGAAGAATCTAAAGGAGCTCAAGTTGTTAACCTTGAAAAATACGGCATTGAACACCCTGCTCTTATTAAGAAATCTGATGGTGCTACTCTCTATATTACCCGCGATTTGGCAGCAGCCATTTATCGCAAACGTACCTATGACTTTGCTAAAGCTATCTATGTTGTCGGTCAGGAACAAACTGCTCATTTCAAGCAATTAAAAGCTGTATTAGCTGAAATGGGCTATGCTTGGAGTAAAGATATCCAGCATGTCTCTTTTGGCCTTGTTACTAAAAATGGTCAAAAATTATCCACCCGCAAAGGAAATGTTATCTTACTTGAGCCAACAATTGCTGAAGCTGTCAAACGCTCTTTAGCGCAAATTGATACTAAAAACCCTGATTTAGTTAATAAAGAAGCCGTTGCCCATGCTGTTGGTGTAGGAGCGATAAAATTCTATGACCTTAAAACAGACCGAACAAATGGCTATGATTTTGATCTTGAAGCTATGGTCTCTTTTGAAGGCGAAACAGGTCCTTATGTTCAATATGCTCATGCCCGTATTCAATCTATCCTTAGAAAAGCTGATTTTCAGCCTCAGGCAACAGAAAACTATCAGTTAAATGACACTGAAAGTTGGGAGATTATTAAACTCATTCAGGACTTTCCAAATACCATCGTTAGAGCAGCTGATAATTTTGAGCCCTCCCTTATTGCTAGATTTGCTATTCACTTAGCACAAAGCTTTAACAAATATTATGCACACACACGCATTCTTGATAATAGCCCTGAACGTGACAGCCGTCTTGCACTCAGTTATGCCACTGCAACTGTTCTCAAAGAAGCCTTAGCCCTTCTGGGTGTTGAGGCGCCTAATGAAATGTAA","6.00","-7.80","63564","MNHNRLIAKEIAAIVPALEQETILNLLEKPKKSSMGDLAFPTFSLAKTMRKAPQIIASELVGQINNSYFEKVEAVGPYINFFLNKSEISAQVLKEVIKKREDYAQAAIGQGHNIVIDLSSPNIAKPFSIGHLRSTVIGDALSNIFQKLGYETVKINHLGDWGKQFGMLIVAYKKWGSEEAVRAHPIDELLKIYVRINAETKNHPELDEEAREWFRKLENNDEEALALWQWFRDESLMEFNRLYAELGIDFDSYNGEAFYNDKMEEVVQLLAEKGLLEESKGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAAIYRKRTYDFAKAIYVVGQEQTAHFKQLKAVLAEMGYAWSKDIQHVSFGLVTKNGQKLSTRKGNVILLEPTIAEAVKRSLAQIDTKNPDLVNKEAVAHAVGVGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYVQYAHARIQSILRKADFQPQATENYQLNDTESWEIIKLIQDFPNTIVRAADNFEPSLIARFAIHLAQSFNKYYAHTRILDNSPERDSRLALSYATATVLKEALALLGVEAPNEM","1968346","For other 'arg' genes see SMu0512 (argF); SMu0531 (argR); SMu0605 (argC);SMu0606 (argJ); SMu0607 (argB);SMu0608 (argD); SMu1903 (argR);SMu1900 (argR); SMu0238 (argF); SMu0300 (argG) and SMu0301 (argH).From GenBank (gi:2501051): In yeast, this protein catalyzes the reaction: ATP + L-arginine + tRNA(ARG) = AMP + pyrophosphate + L-arginyl-tRNA(ARG). It is a cytoplasmic monmer that belongs to class-I aminoacyl-tRNA synthetase family.","arginyl-tRNA synthetase","Cytoplasm","Many strong matches in gapped BLAST to Arginyl-tRNA synthetase; e.g. residues 1-563 are 79% similar to Arginyl-tRNA synthetase of Streptococcus pneumoniae (gi15903931); residues 1-563 are 62% similar to Arginyl-tRNA synthetase of Lactococcus lactis (gi15674020).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2103 (0.0).","

InterPro
IPR001278
Family

Arginyl-tRNA synthetase, class Ic
PR01038	$\"[113-128]T$ $\"[128-144]T$ $\"[152-165]T$ $\"[297-318]T$	TRNASYNTHARG
PTHR11956	$\"[23-563]T$	Arg_tRNA-synt_1c
PF00750	$\"[92-436]T$	tRNA-synt_1d
TIGR00456	$\"[3-563]T$	argS

InterPro
IPR005148
Domain

Arginyl tRNA synthetase, N-terminal
PF03485	$\"[1-83]T$	Arg_tRNA_synt_N

InterPro
IPR008909
Domain

DALR anticodon binding
PF05746	$\"[450-563]T$	DALR_1

InterPro
IPR009080
Domain

Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
SSF47323	$\"[445-563]T$	tRNAsyn_1a_bind

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[110-453]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
G3DSA:1.10.730.10	$\"[454-563]T$	G3DSA:1.10.730.10
G3DSA:3.30.1360.70	$\"[2-101]T$	G3DSA:3.30.1360.70
SSF52374	$\"[105-444]T$	SSF52374
SSF55190	$\"[1-104]T$	SSF55190

","BeTs to 17 clades of COG0018COG name: Arginyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0018 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 126-351 are 66% similar to a (SYNTHETASE LIGASE ARGINYL-TRNA) protein domain (PD002803) which is seen in Q9CE12_LACLA.Residues 373-501 are 64% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD186118) which is seen in Q9CE12_LACLA.Residues 204-313 are 38% similar to a (SYNTHETASE LIGASE ARGINYL-TRNA) protein domain (PD332378) which is seen in Q9HUC8_PSEAE.Residues 12-101 are 54% similar to a (SYNTHETASE LIGASE ARGINYL-TRNA) protein domain (PD003204) which is seen in Q9CE12_LACLA.Residues 504-560 are 66% similar to a (SYNTHETASE LIGASE ARGINYL-TRNA) protein domain (PD330902) which is seen in Q9KGV6_LACLA.Residues 172-351 are 27% similar to a (SYNTHETASE PROTEOME COMPLETE) protein domain (PD256250) which is seen in Q9HHN2_HALN1.Residues 449-563 are 28% similar to a (SYNTHETASE LIGASE ARGINYL-TRNA) protein domain (PD407561) which is seen in Q9PNC0_CAMJE.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 11:12:28 2006","Thu Aug 24 11:12:28 2006","Thu Aug 24 11:12:28 2006","Wed Apr 3 09:27:14 2002","","Thu Jan 3 23:35:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1904 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Sun Jan 6 09:21:52 2002","Thu Aug 24 11:12:28 2006","pdb1BS2A Chain A, Yeast Arginyl-Trna Synthetase 373 3e-104","SMU.2098","","Residues 1 to 83 (E-value = 4.3e-28) place SMu1904 in the Arg_tRNA_synt_N family which is described as Arginyl tRNA synthetase N terminal domain (PF03485)Residues 92 to 436 (E-value = 2.5e-106) place SMu1904 in the tRNA-synt_1d family which is described as tRNA synthetases class I (R) (PF00750)Residues 450 to 563 (E-value = 3e-47) place SMu1904 in the tRNA-synt_1d_C family which is described as DALR anticodon binding domain (PF05746)","Thu Aug 24 11:12:28 2006","24380431","","","Cavarelli,J., Delagoutte,B., Eriani,G., Gangloff,J. and Moras,D. L-arginine recognition by yeast arginyl-tRNA synthetase. EMBO J. 17 (18), 5438-5448 (1998) PubMed: 9736621.Chou,L.-S., Weimer,B. and Xie,Y. Arginine Metabolism in Lactococcus lactis ssp. lactis ML3: Analysis of Gene Structure and Study of Expression Profiles Using the Small Scale DNA Array. Unpublished.","","Sun Jan 6 09:28:35 2002","1","","","SMU.2098","201" "SMu1905","1969260","1968382","879","ATGAAAATAGATTATACTCTTCGTCTAAAAAATTTTATTTTTATTGCCTTAGGTGTAGCCATTTATGCTTTTGGTTTTGTCAATTTTAATATGACAAATCATATTGCTGAGGGAGGTATGGCCGGTTTAACTTTAGTTTTTCATGCCCTCTTTGGTATCAATCCAACTTATACTGGCTATCTATTTAACTTGCCTTTACTGTTGTTTGGAATTTATTTTTTTGGTCGCAAAATGATGGTTTACACCATTTATGGAACAACGTTGATGTACTTTTTTGTCTATATCTTTCAAAAAATCCCTCTTTATATTGATTTACAGCATGATTATCTAGTCGTCGCTTTAGTGGCTGGTATCTGTGCAGGTATTGGTAATGGAATTGTTTTTCGTTATGGGGGGACTACCGGTGGTTCAGATATTATTGCTCGTGTTATGGAGGATAAGTATGGTATTCAATTGGGTCAGGCTTTATTAATTTTTGATATTTTTGTTATGCTCTTATCTTTGACTTATGTCTCCATTCCTCAAATGATGTATGCTCTGATTGCTAGCTTTATGTTCAGTCAAGTGGTTATTTTAGTCCAAAATGGTGGCTATTCTGTTCGAGGAGTCTTGATCATTACTGATAAGCATGAAGAAGTGGCTGAAGCCATTCTTGAAGAACTCAATCGAGGCGCTACTTATTTAAAAGGTCAAGGTGCTTATTCAGGTAAAGAAAAAAATGTTCTGTATGTTGCTTTAAATCCTACAGATGTTAGGTTATTAAAGGAAATGATGGAAAAACTTGATCCAGATGCCTTCATTTCGATTTTAAATGTTGAAGAAATTATTAGTCCTGACTTTATTGTTAGTAAGCGTGAACGCAAACTAGCCTATAGATAG","7.00","0.00","32847","MKIDYTLRLKNFIFIALGVAIYAFGFVNFNMTNHIAEGGMAGLTLVFHALFGINPTYTGYLFNLPLLLFGIYFFGRKMMVYTIYGTTLMYFFVYIFQKIPLYIDLQHDYLVVALVAGICAGIGNGIVFRYGGTTGGSDIIARVMEDKYGIQLGQALLIFDIFVMLLSLTYVSIPQMMYALIASFMFSQVVILVQNGGYSVRGVLIITDKHEEVAEAILEELNRGATYLKGQGAYSGKEKNVLYVALNPTDVRLLKEMMEKLDPDAFISILNVEEIISPDFIVSKRERKLAYR","1968400","","conserved hypothetical protein","Membrane, Cytoplasm","Many strong matches in gapped BLAST to conserved hypothetical protein; e.g. residues 4-285 are 57% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675895); residues 15-290 are 53% similar to conserved hypothetical protein of Lactococcus lactis (gi|15673944).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2105 (2e-96).","

InterPro
IPR003740
Family

Protein of unknown function DUF161
PF02588	$\"[11-93]T$ $\"[109-190]T$	DUF161

InterPro
IPR006052
Family

Tumor Necrosis Factor
PS00251	$\"[64-80]?$	TNF_1

InterPro
IPR003740
Family

Protein of unknown function DUF161
PF02588	$\"[38-126]T$ $\"[138-219]T$	DUF161

","BeTs to 5 clades of COG1284COG name: Uncharacterized BCR, YitT familyFunctional Class: SThe phylogenetic pattern of COG1284 is ------v--B----GPo-in-Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 225-310 are 43% similar to a (PROTEOME COMPLETE TRANSMEMBRANE YUDL) protein domain (PD007590) which is seen in Q9CE81_LACLA.Residues 53-218 are 55% similar to a (COMPLETE PROTEOME TRANSMEMBRANE MG443) protein domain (PD006310) which is seen in Q9CE81_LACLA.Residues 126-214 are 24% similar to a (PROTEOME BH2964 COMPLETE) protein domain (PD393874) which is seen in Q9K8N9_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:01:20 2002","Wed Jan 2 15:53:36 2002","Wed Jan 2 15:53:36 2002","Mon Apr 15 14:26:31 2002","","Wed Jan 2 15:53:36 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1906 is paralogously related (blast p-value < 1e-3) to SMu1905, a predicted conserved hypothetical protein.","Mon Apr 15 14:26:31 2002","","No significant hits to the NCBI PDB database.","SMU.2100c","","Residues 38 to 126 (E-value = 3.3e-17) place SMu1906 in the DUF161 family which is described as Uncharacterized BCR, YitT family COG1284 (PF02588)Residues 138 to 219 (E-value = 4.2e-26) place SMu1906 in the DUF161 family which is described as Uncharacterized BCR, YitT family COG1284 (PF02588)","Wed Jan 2 15:53:36 2002","24380433","","","","","","1","","","SMU.2100c","496" "SMu1907","1971985","1970216","1770","ATGAAACGTTCTATGTATGCTGGTGCTGTGCGTTCAGAACACATCGGACAAGAGTTAACCCTTAAAGGCTGGGTGGCTCGCCGGCGTGATTTAGGAGGTCTTATTTTTATTGATTTGCGCGATCGCGAAGGCATTGTGCAACTAGTCATTAATCCTAAAACTGCCAGTAATACTGTTGTTAAAAGTGCTGAAAGCTTGCGGAGTGAGTATGTTATCGAAGTGACAGGGATGATTGTGGAGCGTGATCAAGCTAATGATAATTTACCAACGGGTTGTGTCGAAATGCAGGTGACGCAGTTAACGATTTTAAATGCTTCACAAACACCGCCCTTTGAAATTAAGGATAAAATTGAAGCCAATGATGACACACGTTTACGTTATCGTTACCTCGATCTTCGTCGTCCAGAAATGCTGAAAAATTTTAAGTTACGTGCTAAGGTCACACATGTTATCCGCAATTATCTGGATGACTTGGATTTCATAGATGTTGAGACACCTATGCTTGCCAAGTCAACACCAGAAGGAGCGCGTGATTATTTAGTACCAAGCCGTATGAGTCGAGGGCATTTTTATGCTCTTCCTCAAAGTCCGCAGATTACCAAACAGCTTTTAATGAATGCAGGTTTTGATCGTTATTACCAAATTGTCAAATGTTTTCGTGATGAAGACTTACGTGGAGACCGTCAACCTGAATTTACACAAGTTGATTTGGAAACTTCCTTTTTATCTGAACAAGAAATTCAAGAAATCACAGAAAGATTGATTGCTTGTGTCATGAAGGAAGTCAAGGGCATAGAGTTGCAATTACCACTTCCCCAAATATCTTATGATACAGCAATGAACAATTATGGTTCTGATAAACCGGATACTCGCTTTGAAATGACTTTACAGGACTTGACAGATCTTGTAAAGAATATTGATTTCAAAGTATTCTCACAGGCTCCTGCTGTAAAAGCTATTGTTGCTAAAAATGCTGCAAATAGCTATTCTCGCAAAGCAATTGATAAGTTGACAGATATTGTAAAGCCATTTGGTGCAAAGGGTCTTGCTTGGGTTAAATATAATGATGGCAAAATAGGTGGTCCTATTGCTAAGTTTTTGACAACTATTGAAGATGAGTTGATAGAACGTTTACAGCTTGAAGCAAATGATTTAGTGTTTTTTGTAGCAGATGATCTTGAAATAGCAAATGGTAGTCTTGGTGCTCTGCGTAACCACTTGGCAAAAGAACTAAACCTTATAGACCATTCGAAATTTAATTTCTTATGGGTTGTGGATTGGCCAATGTTTGAATGGTCTGAGGAAGAAAATCGCTATACAAGTGCTCACCATCCTTTCACTTTACCGCAAGAAGATACGGTTGCTGAACTTGAAGGTGATCTCAGCAAGGTTCGTGCTGTTGCATATGACATTGTTCTTAATGGTTATGAGCTTGGCGGGGGTAGTCTTCGTATCAATCAGAGAGAGACACAAGAACGTATGTTCAAGGCGCTTGGATTTACAAAAGAAAGCGCTCAAAAACAATTTGGCTTTTTACTGGAAGCTATGGATTATGGTTTTCCGCCTCATGGAGGACTAGCGCTTGGATTGGATCGATTTGTTATGCTTTTAGCAGGAAAAGAGAATATTCGTGAAGTGATTGCCTTTCCTAAGAATAATAAAGCTTCAGATCCAATGACACAAGCCCCAAGTTTAGTTTCTGATAAACAACTTGATGAGCTTTATTTGCAAGTAAACAAGAATGCAGTAAAGAACAATGAACAAGAATAA","5.20","-13.14","66959","MKRSMYAGAVRSEHIGQELTLKGWVARRRDLGGLIFIDLRDREGIVQLVINPKTASNTVVKSAESLRSEYVIEVTGMIVERDQANDNLPTGCVEMQVTQLTILNASQTPPFEIKDKIEANDDTRLRYRYLDLRRPEMLKNFKLRAKVTHVIRNYLDDLDFIDVETPMLAKSTPEGARDYLVPSRMSRGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLSEQEIQEITERLIACVMKEVKGIELQLPLPQISYDTAMNNYGSDKPDTRFEMTLQDLTDLVKNIDFKVFSQAPAVKAIVAKNAANSYSRKAIDKLTDIVKPFGAKGLAWVKYNDGKIGGPIAKFLTTIEDELIERLQLEANDLVFFVADDLEIANGSLGALRNHLAKELNLIDHSKFNFLWVVDWPMFEWSEEENRYTSAHHPFTLPQEDTVAELEGDLSKVRAVAYDIVLNGYELGGGSLRINQRETQERMFKALGFTKESAQKQFGFLLEAMDYGFPPHGGLALGLDRFVMLLAGKENIREVIAFPKNNKASDPMTQAPSLVSDKQLDELYLQVNKNAVKNNEQE","1970234","For other 'asp' genes see SMu1199 (aspB) (aspC); SMu1660 (aspS) and SMu1667 (aspG). From GenBank (gi:3122885): In Bacillus subtilis, this enzyme catalyzes the reaction: ATP + L-aspartate + tRNA(ASP) = AMP + pyrophosphate + L-aspartyl-tRNA(ASP). This cytoplasmic homodimer belongs to the Class-II aminoacyl-tRNA synthetase family.","aspartyl-tRNA synthetase","Cytoplasm","Numerous strong matches in gapped BLAST to aspartyl-tRNA synthetase; e.g. residues 1-581 are 73% similar to aspartyl-tRNA synthetase of Streptococcus pyogenes (gi|15675898); residues 3-585 are 53% similar to aspartyl-tRNA synthetase of Bacillus subtilis (gi|3122885).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2107 (0.0).","

InterPro
IPR002312
Family

Aspartyl-tRNA synthetase, class IIb
PR01042	$\"[193-205]T$ $\"[210-223]T$ $\"[469-485]T$ $\"[513-527]T$	TRNASYNTHASP

InterPro
IPR004115
Domain

GAD
PF02938	$\"[311-400]T$	GAD

InterPro
IPR004364
Domain

tRNA synthetase, class II (D, K and N)
PF00152	$\"[120-554]T$	tRNA-synt_2

InterPro
IPR004365
Domain

Nucleic acid binding, OB-fold, tRNA/helicase-type
PF01336	$\"[19-103]T$	tRNA_anti

InterPro
IPR004524
Family

Aspartyl-tRNA synthetase bacterial/mitochondrial type
PTHR22594:SF5	$\"[90-581]T$	AspS_bac
TIGR00459	$\"[1-582]T$	aspS_bact

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[141-550]T$	AA_TRNA_LIGASE_II

InterPro
IPR012340
Domain

Nucleic acid-binding, OB-fold
G3DSA:2.40.50.140	$\"[1-109]T$	OB_NA_bd_sub

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[134-581]T$	G3DSA:3.30.930.10
PTHR22594	$\"[90-581]T$	PTHR22594
SSF50249	$\"[1-107]T$	Nucleic_acid_OB
SSF55261	$\"[292-414]T$	SSF55261
SSF55681	$\"[98-581]T$	SSF55681

","BeTs to 13 clades of COG0173COG name: Aspartyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0173 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 513-550 are 94% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000848) which is seen in Q9CE80_LACLA.Residues 137-208 are 70% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD330536) which is seen in Q9CE80_LACLA.Residues 15-120 are 46% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD190154) which is seen in Q9KDG1_BACHD.Residues 465-498 are 64% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD383364) which is seen in SYD_SYNY3.Residues 466-512 are 76% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD006889) which is seen in Q9KDG1_BACHD.Residues 513-550 are 55% similar to a (SYNTHETASE LIGASE LYSYL-TRNA) protein domain (PD186099) which is seen in SYK_UREPA.Residues 210-279 are 80% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA ATP-BINDING) protein domain (PD000871) which is seen in Q9CE80_LACLA.Residues 36-118 are 55% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD017062) which is seen in Q9CE80_LACLA.Residues 378-449 are 68% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD190340) which is seen in Q9CE80_LACLA.Residues 370-458 are 42% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD206474) which is seen in SYD_ECOLI.Residues 280-366 are 54% similar to a (SYNTHETASE LIGASE ASPARTYL-TRNA) protein domain (PD037346) which is seen in Q9KDG1_BACHD.Residues 17-115 are 42% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD381092) which is seen in SYD_MYCTU.Residues 3-118 are 50% similar to a (SYNTHETASE LIGASE ASPARTYL-TRNA) protein domain (PD228079) which is seen in SYD_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 17:28:45 2002","Wed Jan 2 15:42:56 2002","Thu Oct 10 17:28:45 2002","Mon Apr 8 13:07:58 2002","","Wed Jan 2 15:42:56 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1907 is paralogously related (blast p-value < 1e-3) to SMu1660,a predicted aspartyl-tRNA synthetase; SMu0701,a predicted a lys-tRNA synthetase and SMu1198, a predicted asn-tRNA synthetase.","Mon Apr 15 14:28:41 2002","Wed Jan 2 15:42:56 2002","pdb|1EFW|A Chain A, Crystal Structure Of Aspartyl-Trna Syntheta... 538 5e-154pdb|1EQR|A Chain A, Crystal Structure Of Free Aspartyl-Trna Syn... 535 5e-153pdb|1C0A|A Chain A, Crystal Structure Of The E. Coli Aspartyl-T... 532 4e-152","SMU.2101c","","Residues 19 to 103 (E-value = 1.9e-19) place SMu1907 in the tRNA_anti family which is described as OB-fold nucleic acid binding domain (PF01336)Residues 120 to 554 (E-value = 4.5e-12) place SMu1907 in the tRNA-synt_2 family which is described as tRNA synthetases class II (D, K and N) (PF00152)Residues 311 to 400 (E-value = 3.5e-31) place SMu1907 in the GAD family which is described as GAD domain (PF02938)","Wed Jan 2 15:42:56 2002","","","","Eriani,G., Dirheimer,G. and Gangloff,J. Aspartyl-tRNA synthetase from Escherichia coli: cloning and characterisation of the gene, homologies of its translated amino acid sequence with asparaginyl- and lysyl-tRNA synthetases. Nucleic Acids Res. 18 (23), 7109-7118 (1990) PubMed: 2129559.Eiler,S., Dock-Bregeon,A., Moulinier,L., Thierry,J.C. and Moras,D. Synthesis of aspartyl-tRNA(Asp) in Escherichia coli--a snapshot of the second step. EMBO J. 18 (22), 6532-6541 (1999) PubMed: 10562565.Rees,B., Webster,G., Delarue,M., Boeglin,M. and Moras,D. Aspartyl tRNA-synthetase from Escherichia coli: flexibility and adaptability to the substrates. J. Mol. Biol. 299 (5), 1157-1164 (2000) PubMed: 10873442.","","Wed Jan 2 15:49:30 2002","1","","","SMU.2101c","202" "SMu1908","1973505","1972216","1290","ATGACATTACAAAAACCAAAAGGAACACAAGATATTCTGCCTCAAGAGACAGTTAAATGGCAGTATGTCGAAAACGTTGCGCGTAAAACTTTTAAAAAATATCATTACGGTGAAATTAGAACGCCCATGTTTGAACGCTATGAGGTCATTAGTCGTTCTGTTGGTGATACGACAGATATTGTAACAAAGGAAATGTATGATTTCCATGATAAGGGAGATCGTCACATCACACTGCGCCCAGAAGGAACAGCTCCTGTTGTTCGTTCTTATGTGGAAAACAAACTTTTTGCGCCCGAGGTACAAAAACCTGTTAAAGTTTTTTATATTGGTTCCATGTTTCGCTATGAGCGGCCTCAGGCAGGACGCTTACGTGAATTTCATCAGTTAGGAGTTGAATGTTTTGGCTCTAACAATCCTGCCATTGATGCAGAAACCATTGCCATGGCTTATCAGCTTTTCAACGAGCTAGGTATCAAAGATGTCACTTTGCACCTTAATAGTTTAGGAAATAAAGAGAGTCGCAAGGCTTATCGTCAGGCTTTGATTGATTATCTGATCCCTATGAAAGACAAACTGTCCAAAGATTCACAGCGCCGCTTAGAAGAAAATCCCTTGCGGGTACTAGATTCTAAAGAAAAAGAAGATAAAGAAGCTGTTGAAAATGCACCGTCTATCTTAGATTATTTGGATGATGACTCACAAGCGCATTTTCAGGGTGTACGTGATATGTTAGAGGTACTTGACATTCCTTATGTTATTGATACCAATATGGTTCGTGGTCTTGACTATTATAACCACACGATTTTTGAATTTATTACTCAAGTTGATAAAAGTGAATTAACGCTTTGCGCTGGCGGTCGGTATGACAGTCTTGTCGAATACTTTGGTGGTCCTGCGACAGCTGGATTCGGATTTGGTCTTGGTTTGGAGCGACTTTTATTGGTTATTGACAAACAAAAGATTAATCTGCCAGTAGATAACAGTTTAGATGTCTATATAGCTGTACTTGGTGCAGCTGCTAATAGTACGGCTTTAGAACTTATTCAAGCTATTCGTAAACAAGGTTTTTCGGCAGAACGTGATTATCTTAGTCGTAAAATTAAAGCACAATTTAAATCGGCAGATGTTTTTAAAACGAAATTGATCATGACTTTAGGTGAGAGTGAAGTTGAAACTGGACAAGTTGCAGTTAAAAATAACTTCACACGACAAGAAATTGCTGTTAGTTTTGAGGAAATTAAAACAGATTTTGCTAGTGTTTTTAAACAATTAGGTTCAGACAGACCATAG","5.80","-5.36","48885","MTLQKPKGTQDILPQETVKWQYVENVARKTFKKYHYGEIRTPMFERYEVISRSVGDTTDIVTKEMYDFHDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQKPVKVFYIGSMFRYERPQAGRLREFHQLGVECFGSNNPAIDAETIAMAYQLFNELGIKDVTLHLNSLGNKESRKAYRQALIDYLIPMKDKLSKDSQRRLEENPLRVLDSKEKEDKEAVENAPSILDYLDDDSQAHFQGVRDMLEVLDIPYVIDTNMVRGLDYYNHTIFEFITQVDKSELTLCAGGRYDSLVEYFGGPATAGFGFGLGLERLLLVIDKQKINLPVDNSLDVYIAVLGAAANSTALELIQAIRKQGFSAERDYLSRKIKAQFKSADVFKTKLIMTLGESEVETGQVAVKNNFTRQEIAVSFEEIKTDFASVFKQLGSDRP","1972234","For other 'his' genes see SMu1153 (hisE); SMu1155 (hisI) (hisE); SMu1156 (hisF); SMu1157 (hisA);SMu1158 (hisH);SMu1160 (hisB); SMu1162 (hisD); SMu1163 (hisG); SMu1164 (hisZ) and SMu1165 (hisC). From GenBank (gi:267058): In S.dysgalactiae subsp. equisimilis, this protein catalyzes the reaction: ATP + L-histidine + tRNA(his) = AMP + pyrophosphate + L-histidyl-tRNA(his). It is a cytoplasmic homodimer that belongs to the class-II aminoacyl-tRNA synthetase family.","histidine-tRNA synthetase","Cytoplasm","Numerous strong matches in gapped BLAST to histidine-tRNA ligases; e.g. residues 1-424 are 75% similar to histidine-tRNA ligase of Streptococcus pyogenes (gi15675899); residues 6-412 are 47% similar to histidyl-tRNA synthetase of Bacillus subtilis (gi3122900).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2108 (0.0).","

InterPro
IPR002314
Domain

tRNA synthetase, class II (G, H, P and S)
PF00587	$\"[19-188]T$	tRNA-synt_2b

InterPro
IPR004154
Domain

Anticodon-binding
G3DSA:3.40.50.800	$\"[326-422]T$	Anticodon_bd
PF03129	$\"[330-420]T$	HGTP_anticodon
SSF52954	$\"[326-422]T$	Anticodon_bd

InterPro
IPR004516
Family

Histidyl-tRNA synthetase, class IIa
PIRSF001549	$\"[1-419]T$	His-tRNA_synth

InterPro
IPR006195
Domain

Aminoacyl-transfer RNA synthetase, class II
PS50862	$\"[23-324]T$	AA_TRNA_LIGASE_II

InterPro
IPR015805
Family

Histidyl-tRNA synthetase
PTHR11476	$\"[1-422]T$	His-tRNA_synth

InterPro
IPR015807
Family

Histidyl-tRNA synthetase 1
TIGR00442	$\"[1-417]T$	hisS

noIPR
unintegrated

unintegrated
G3DSA:3.30.930.10	$\"[1-323]T$	G3DSA:3.30.930.10
SSF55681	$\"[2-320]T$	SSF55681

","BeTs to 17 clades of COG0124COG name: Histidyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0124 is amtkYQVCeBrhujgpolinxNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 330-413 are 69% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA BIOSYNTHESIS) protein domain (PD000606) which is seen in SYH_STREQ.Residues 227-294 are 82% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD001912) which is seen in SYH_STREQ.Residues 68-158 are 89% similar to a (SYNTHETASE LIGASE HISTIDYL-TRNA) protein domain (PD403250) which is seen in SYH_STREQ.Residues 3-66 are 35% similar to a (SYNTHETASE HISTIDYL-TRNA LIGASE) protein domain (PD412747) which is seen in SYH_RICPR.Residues 73-158 are 53% similar to a (SYNTHETASE HISTIDYL-TRNA AMINOACYL-TRNA) protein domain (PD404510) which is seen in SYH_HAEIN.Residues 68-289 are 33% similar to a (SYNTHETASE HISTIDYL-TRNA LIGASE) protein domain (PD416012) which is seen in SYH_METTH.Residues 165-223 are 45% similar to a (SYNTHETASE LIGASE HISTIDYL-TRNA) protein domain (PD404234) which is seen in Q9KXP2_STRCO.Residues 42-167 are 26% similar to a (PROTEOME COMPLETE SUBUNIT REGULATORY) protein domain (PD120527) which is seen in HISZ_LACLA.Residues 6-66 are 41% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD404351) which is seen in SYH_CHLTR.Residues 6-66 are 36% similar to a (SYNTHETASE LIGASE HISTIDINE--TRNA) protein domain (PD412913) which is seen in SYH_MYCLE.Residues 3-66 are 85% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD336444) which is seen in SYH_STREQ.Residues 187-226 are 87% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD414457) which is seen in SYH_STREQ.Residues 1-56 are 62% similar to a (SYNTHETASE LIGASE HISTIDYL-TRNA) protein domain (PD169451) which is seen in Q9CE78_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 24 11:15:52 2006","Wed Nov 6 10:34:15 2002","Thu Aug 24 11:15:52 2006","Mon Apr 8 11:37:09 2002","","Wed Jan 2 15:32:55 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1908 is paralogously related (blast p-value < 1e-3) to SMu1164, a predicted histidyl-tRNA synthetase.","Mon Apr 15 15:15:57 2002","Thu Aug 24 11:15:52 2006","pdb1QE0A Chain A, Crystal Structure Of Apo S. Aureus Histidyl... 364 1e-101pdb1KMMC Chain C, Histidyl-Trna Synthetase Complexed With His... 308 1e-084pdb1HTTA Chain A, Histidyl-Trna Synthetase >gi1942450pdb1H... 308 1e-084","SMU.2102c","","Residues 8 to 160 (E-value = 8.7e-50) place SMu1908 in the tRNA-synt_2b family which is described as tRNA synthetase class II core domain (G, H, P, S and T) (PF00587)Residues 330 to 420 (E-value = 1.3e-18) place SMu1908 in the HGTP_anticodon family which is described as Anticodon binding domain (PF03129)","Thu Aug 24 11:15:52 2006","","","Menguito,C.A., Keherly,M.J., Tang,C., Papaconstantinou,J. and Weigel,P.H. Molecular cloning, sequence, structural analysis and expression of the histidyl-tRNA synthetase gene from Streptococcus equisimilis. Nucleic Acids Res. 21 (3), 615-620 (1993) PubMed: 8441673.","","Wed Jan 2 15:36:09 2002","","1","","","SMU.2102c","203" "SMu1909","1973798","1975642","1845","GTGTTTAAAACTTTAAAAACTTTACTATTAGGGGAACCCTTAAAATCTGAATTAGAAGGAGATAGCCATGCATTAACAAAATTGCAAGCATTGGCTATGTTGTCAAGCGATGCTTTATCATCTATCGCTTACGGACCCGAGCAAGTTATTTTAGTTTTGATAGCTTTATCAGAAGGAGCTATTTGGTGGTCTTTGCCAATTGGCATTGGAGTACTCGTTTTATTGATTAGTTTAACAATTTCTTACAGTCAGATTATTCACGCCTACCCTAATGGCGGTGGTGCTTACATGGTATCATCAGACAATCTGTCTCCTTCTATGGGGCTCTTAGCAGGCGGGAGTCTGCTGATTGATTATATGCTGACAGTTGCCGTGTCAGTCTCATCTGGAGCAGATGCTATCACGTCAGCCTTCCCAGCATTTAAAGATAGCAATCTTGAAATTTCAATTGTTTTGGTTCTTATTTTAATGCTTATGAATCTACGCGGTCTGCGTGAATCAGCTACGGCACTTTTTGTCCCTGTTTATTTTTTCATTATATCCATTCTCTTTTTACTAATCTGTGGACTTTTCCAAATCGTTACTGGAAATCTCACTTACACCGCAACAGCTCATATTGGACAGCCCATATCAGGCCTGACTTTAGTCTTGCTGCTGCGTGCTTTTACTAGCGGTTCTGCTTCTTTGACCGGAGTTGAAGCCATTTCAAACGCCGTCCCTTTTTTTAAAAAACCAAAAGCAAAAAATGCGGTTAAAACGTTAACCATGATGTCTGCTATTCTCGGAGCTATGTTTATCGGAATCACTTTTCTCAACTATTGGCTCGGTATTATCCCCAATCATAACGTAACTATCTTAGCACAAATAGCTCAGAAAGTTTTCGGCCACAGCTTCATCGGACAAGTATTCTTTTATCTTTTCCAAATTGCAACAGCCCTTATCTTAGCAGTCGCTGCTAATACTGGATTTTCAGCTTTTCCGATTCTTTCTTATAATATGGCAAAGAACAAATACATGCCTCATCTTTATTTGGAAAAGGGAGCTCGTCTAGGGTATTCTAATGGTATTTTAACATTAGCTATTGGTGCTATTTGCTTACTCTTTATTTTTAACGGTTCCACTGAACGTCTGATACCGCTTTATACTATCGGTGTTTTTATCCCCTTTGCATTAGCACAGACAGGAATGATCATTTATTGGAAAAACCTTAAAGAAAAAAACTTTTTCAAACAGGCTTTGGCAAATGTCGTTGGTGCCATCATTTGCTATGCTATTATTTTGATTCTCTTGATTTTCCGTCTGCATGATATTTGGCCTTTCTTCCCGATTATTGCTATTTTAATTGCCATGTTCCACAAAATAAAAAGTCACTACAATAGTGTCGCAGAGCAGCTGCGTATTACTGATAAAAATAAAGCCGTCTGCTATTCTGACAATAAAGTCCTTGTACTCGTCGGCAATATGACACAGGCTACTATTGGAGCTGTTAATTATGCACATTCTCTCAGTAAAGATGTTATCGCTTTGCATGTCTCAACAACAGAAACACTTAGCAAAGATCATGAAGTTGAAGAAGAGTTTAAACAGTTTTTCCCAAATATCACCTTTGTCAATGTTTACTCTGATTACCGTGATATCATTAAGCCAACAGTTAATTATGTTAATGCAGCCAGTCAGAAAGCAAAAGCTCATAACAGCACTCTAACCGTACTAATACCACAATTCGTTCCGCGTAAGCCTTGGCAAACTCTGCTGCATAATCAAATGAATCTCCGTCTCAAATATTATCTCAGATGGAACCAAGATATCATCATTTCCAGCTATTCCTTCCATCTTAAGAAATAA","10.10","16.42","67640","MFKTLKTLLLGEPLKSELEGDSHALTKLQALAMLSSDALSSIAYGPEQVILVLIALSEGAIWWSLPIGIGVLVLLISLTISYSQIIHAYPNGGGAYMVSSDNLSPSMGLLAGGSLLIDYMLTVAVSVSSGADAITSAFPAFKDSNLEISIVLVLILMLMNLRGLRESATALFVPVYFFIISILFLLICGLFQIVTGNLTYTATAHIGQPISGLTLVLLLRAFTSGSASLTGVEAISNAVPFFKKPKAKNAVKTLTMMSAILGAMFIGITFLNYWLGIIPNHNVTILAQIAQKVFGHSFIGQVFFYLFQIATALILAVAANTGFSAFPILSYNMAKNKYMPHLYLEKGARLGYSNGILTLAIGAICLLFIFNGSTERLIPLYTIGVFIPFALAQTGMIIYWKNLKEKNFFKQALANVVGAIICYAIILILLIFRLHDIWPFFPIIAILIAMFHKIKSHYNSVAEQLRITDKNKAVCYSDNKVLVLVGNMTQATIGAVNYAHSLSKDVIALHVSTTETLSKDHEVEEEFKQFFPNITFVNVYSDYRDIIKPTVNYVNAASQKAKAHNSTLTVLIPQFVPRKPWQTLLHNQMNLRLKYYLRWNQDIIISSYSFHLKK","1975654","","aminoacid specific permease","Membrane, Cytoplasm","Several strong matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 5-614 are 44% similar to unknown protein of Listeria innocua (gi16801300); residues 1-614 are 39% similar to conserved hypothetical protein of Bacillus subtilis (gi7474524).SMu1909 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR006741
Family

Accessory gene regulator B
SM00793	$\"[23-191]T$	no description

noIPR
unintegrated

unintegrated
tmhmm	$\"[42-60]?$ $\"[66-86]?$ $\"[107-127]?$ $\"[146-164]?$ $\"[174-194]?$ $\"[222-242]?$ $\"[257-277]?$ $\"[309-329]?$ $\"[350-370]?$ $\"[380-400]?$ $\"[412-432]?$	transmembrane_regions

","BeTs to 4 clades of COG0531COG name: Amino acid transportersFunctional Class: EThe phylogenetic pattern of COG0531 is AMt-Y--cEBRh--GP--INXNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 6-92 are 29% similar to a (PROTEOME COMPLETE MEMBRANE YDAO) protein domain (PD404503) which is seen in P96589_BACSU.Residues 93-176 are 39% similar to a (MEMBRANE PROTEOME COMPLETE INTEGRAL) protein domain (PD407516) which is seen in O54098_STRCO.Residues 210-613 are 41% similar to a (PROTEOME COMPLETE MEMBRANE YDAO) protein domain (PD017696) which is seen in P96589_BACSU.Residues 93-176 are 54% similar to a (ACID AMINO PROTEOME COMPLETE) protein domain (PD000214) which is seen in P96589_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 14:00:09 2002","Thu Mar 1 14:23:34 2007","Thu Mar 1 14:23:34 2007","Mon Apr 15 15:16:34 2002","","Wed Jan 2 15:26:44 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1909 is paralogously related (blast p-value < 1e-3) to SMu0014, a predicted amino acid permease.","Mon Apr 15 15:16:34 2002","","No significant hits to the NCBI PDB database.","SMU.2104","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:26:44 2002","24380436","","","","","","1","","","SMU.2104","" "SMu1910","1976160","1976285","126","ATGCGATTTTTGAAAGATGAGCTTTCAGTATCAGTAAGATTGCAGGAAAAGTCGATTGAAGCTCTACCTTTTAGAACAAAAATTGAAATAGAAATTGAATCGGATAATCAAATAAAAACGCTCTAG","5.00","-1.01","4831","MRFLKDELSVSVRLQEKSIEALPFRTKIEIEIESDNQIKTL","1976297","","hypothetical protein","Cytoplasm, Extracellular","No significant hits using gapped BLAST.SMu1910 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:59:08 2002","Wed Jan 2 15:14:35 2002","Wed Jan 2 15:14:35 2002","Wed Jan 2 15:14:35 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1910 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:59:08 2002","","No significant hits to the NCBI PDB database.","SMU.2105","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:14:35 2002","24380438","","","","","","1","","","SMU.2105","" "SMu1911","1976650","1976393","258","ATGAAACAAGAATCTTCTATCAACTGCTCTTTGACGCAAGCAGGGATTAATGCTATGCAGCAATGGCTGGGATGTCAACTGAGTCCCAATATAAAATTATGTTTAGATTTTTCCGAAAGAAAGTTTCATGTTGGCGGAGCATCAGGAGAAAAGATATTAGAAAAACTAATCCATGAGAGAAAATGTCAATTAACTCAAAATAGGCAGATTGTTTTAAAAACTGACTTAAATAATTTAATGAAGGATTTTTATAAGTAA","8.90","4.27","9738","MKQESSINCSLTQAGINAMQQWLGCQLSPNIKLCLDFSERKFHVGGASGEKILEKLIHERKCQLTQNRQIVLKTDLNNLMKDFYK","1976411","","hypothetical protein","Cytoplasm","No significant hits using gapped BLAST.SMu1911 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:57:27 2002","Wed Jan 2 15:13:46 2002","Wed Jan 2 15:13:46 2002","Wed Jan 2 15:13:46 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1911 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:57:27 2002","","No significant hits to the NCBI PDB database.","SMU.2106c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:13:46 2002","24380439","","","","","","1","","","SMU.2106c","" "SMu1912","1976941","1976672","270","ATGACTATGTCAACGTCACAAATGATCTCGGTTTTATCAGCTAATCGTTTTCTCACTCAAAGTGAGATTGCTTTTTTAAAAGCTAGTCCTGAAATAGTCTTATTTAACTTTTACGGACGAATTTATTATGAATTAAATAATAATGCCCCCATCAAAGAGCAAGGAAGACTAGTCATTGAAAAACTGTCTAGGTATCCTCAAGCAATTAAGCTTGGCAAATCACGGACATGTTTGCCATTTAGCAGGAAAAGTAGGGGTTACAATATTTGA","10.90","7.93","10223","MTMSTSQMISVLSANRFLTQSEIAFLKASPEIVLFNFYGRIYYELNNNAPIKEQGRLVIEKLSRYPQAIKLGKSRTCLPFSRKSRGYNI","1976690","","hypothetical protein","Periplasm, Extracellular","No significant hits using gapped BLAST.SMu1912 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:56:44 2002","Wed Jan 2 15:12:54 2002","Wed Jan 2 15:12:54 2002","Wed Jan 2 15:12:54 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1912 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:56:44 2002","","No significant hits to the NCBI PDB database.","SMU.2107c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 15:12:54 2002","24380440","","","","","","1","","","SMU.2107c","" "SMu1913","1978064","1976967","1098","TTGGCGATTACCATTCAATTTAGCAATTATGCTCTGAAAACAGATGAAACGTTGATACAAAGAATACAATTTGTATATTCTCCTTTAAATGAACTGTTTAGAAGTTTACATGTCTTATTAAATCCACGTCATCATGGAACTAATATTGACTGGGTGATTAGGATACAAAATAAACTTACTAAGGAATTTTATGAAAATCTTCATTACTTTCGACTCTTTTATGAACTTGGTGTTTCTCCTATTTTACTTTGCAATTTTCGTTATCATGCGACAACGATTGAAGAAGAGATACAAAATCTAAAGAAATTTCTTGATGAGTTATCTACTGCTCAGTTAATTGAGCATCTGGAAAAAGTGACAAGTGATCGAGAAAATTCCTTTATTCCGACATTAGCAAGGGGATTAGAATGGAAGGATTTTTCTTTGAATAAGGATAATCAGTTACTTAGTGACTTGAGGAAGGATGCCTCTAGTGTTTATCAACATCTTTTTTCTTTTGTTGATTGGTACCGACAAGAAATATTTGATGAAACTTGGGAAAGCAAAGATATTCAACGAAAACTTTTAACAGAAATCCAGCATCAAGCTTCCTTTTTAAAGGAAAGTGGGTTTAAAGCGATGTTTAACCATCTGCAAATTGACCGCATTCATTGGCGAAAGGACAGACTAGTCATTATTAAGCCGTTTGATAAAGATATTCAGTTAAAGGATAGTGATTCTATTATGTTATTACCAAGTTATTTTATTTGGCCTCATCTGTTTGTTGAATCTTTCAACCAAGGAATTGCTGTTACCTATGATATTACAGAGCAGCCAAGTTACTATAACGCTACACCGGAAAATTTGATTACCATTTTTAAAGCTTTAAGTGACCCTGTTCGTTTACAAATTATGAATTATGTTATTGATAAACCAAGTACAACACAATCTTTGGCTCAAATTTTAGTGATGAGTAATTCCAGTGTATCCAGACATCTGCAAATTTTAAAGGAGGCTAACTTATTAACAACAACAAAAGCTAAAAAATTCGTTCTTTATGAGCCAACACAGCTCATTACACAACTTATGCCAAATTTCTACCATTTTTTTAAAAATTGA","7.00","0.00","43272","MAITIQFSNYALKTDETLIQRIQFVYSPLNELFRSLHVLLNPRHHGTNIDWVIRIQNKLTKEFYENLHYFRLFYELGVSPILLCNFRYHATTIEEEIQNLKKFLDELSTAQLIEHLEKVTSDRENSFIPTLARGLEWKDFSLNKDNQLLSDLRKDASSVYQHLFSFVDWYRQEIFDETWESKDIQRKLLTEIQHQASFLKESGFKAMFNHLQIDRIHWRKDRLVIIKPFDKDIQLKDSDSIMLLPSYFIWPHLFVESFNQGIAVTYDITEQPSYYNATPENLITIFKALSDPVRLQIMNYVIDKPSTTQSLAQILVMSNSSVSRHLQILKEANLLTTTKAKKFVLYEPTQLITQLMPNFYHFFKN","1976985","For other 'mep' genes see SMu1914 (mepA).","transcriptional regulator, MepR protein (possible regulator of MepA)","Cytoplasm","Matches in gapped BLAST to MepR:residues 207-365 are 100% similar to the previously published MepR in S.mutans (gi|4587160|). Residues 280-347 are 35% similar to a probable transcriptional regulator in Clostridium perfringens (gi|18310013|) and residues 277-346 are 36% similar to ArsR-family transcriptional regulator from S.coelicolor A3(2) (gi|6855368|).SMu1913 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001845
Domain

Bacterial regulatory protein, ArsR
PR00778	$\"[286-301]T$ $\"[318-333]T$ $\"[333-348]T$	HTHARSR
PF01022	$\"[291-337]T$	HTH_5
SM00418	$\"[284-357]T$	HTH_ARSR
PS50987	$\"[274-365]T$	HTH_ARSR_2

InterPro
IPR011991
Domain

Winged helix repressor DNA-binding
G3DSA:1.10.10.10	$\"[267-346]T$	no description

","BeTs to 10 clades of COG0640COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0477 is AMTK-qVCEBR----------Number of proteins in this genome belonging to this COG is 2","","","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 16:32:42 2002","Wed Jan 2 15:10:05 2002","Thu Oct 10 16:32:42 2002","Fri Apr 19 10:50:31 2002","Mon Mar 11 15:04:47 2002","Mon Mar 11 15:04:47 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1913 is paralogously related (blast p-value < 1e-3) to SMu1499, a predicted transcriptional regulator .","Mon Apr 15 15:17:37 2002","Mon Mar 11 15:04:47 2002","","SMU.2108c","","Residues 286 to 358 (E-value = 1.3e-11) place SMu1913 in the HTH_5 family which is described as Bacterial regulatory protein, arsR family (PF01022)","Mon Mar 11 15:04:47 2002","24380441","","","","Mon Mar 11 15:04:47 2002","","1","","","SMU.2108c","" "SMu1914","1978141","1979520","1380","ATGAAAGAAGGGATAAAAATGACGAAACATTTACAAGATTTTTTTATAACAGTTATCGCAGGTATGGGAATGTTATTATCCACCCTTGATACAGGTATTATCAATGTTGCATTATCCTTTTTGAGGGGACAATTTCAAACCACAACTAACATTGCCTCTTTTACAATAACTGGATATACTTTAGCATTAGCTATCTCTATCTTACCTTTAGGAGTATTAAGCGATAAATTTGGAAAGTTAAAGATTTCCTACTTAGGATTTGTACTTTTTGGACTGAGCTCCTTATTTTGTGGATTTGCTAATAGTATTGGCTGGCTCATTACTGGCCGGATTATTCAAGGAATGGGAGCGGCGGCTTTGCAAGCTACTTCAGCAGCTCTGATTACCACTTTAGTTTCCGAAGACCGCAAAAACAGTGCTATTAGTATTTTAGGAGTCATGATTGGTTTAGGGCCTGTTCTAGGACCATCCTTGGGAGGTGTCTTACTTTCTTTAAATCTTTGGCGCTTTATTTTCTGGATTAATGTTCCCTTTGCTCTTATTGTCATCATTTGTAATCACTATCTCCTTACTAAAGTCTCCGAACAAACTAGTGAGTGGACATTAGATTCTCTTGGAACAGTTCTCAATGCTTCTATGTTGGTTTGTCTTCTCTTAGGACTATCCTTACTCAGTAAGCCTCACCTATTAGGTATCAGTCTTATTTTGATCATCATTAGTTTCTTGATCGGGATTTGGTTTTACCGTCTTGAATGCAGCAAAGAGAGTGCTCTTGTCAATGTCAAGGGGCTGAGCGAGAATCCTCGAGTACTTTCTTATCTTTTTCAAACGGTCGCTTTTGGTTTTGCCTCTGCAATGATATTCTTACTTCCACCCTTCATTTTTGAACAATTATATCATTTAGGAGTGGGGCAGACAGGCTTTCTTGTACTAGGAGCACCTGCAGGCCTGGTTCTTTTTTCAAGAATATCTGGTAAAATCAATGATGGCAGTAAAAATAAATCATTTAGCCATATTGGTTTGGGTATCATTATTTTATCCTTAATTTTCCTCCTACTTCTCACGCCTAGCTGGCCCTATTTATTCTTAACTTTAGGATTATTTATTTATGGTATTGGCGGAGGATACTTTCAGCCTGCTAATATGGCTAGTATTATGCTAGCTAGTCCTATGAAAATGCAAGGTAGCACAGGAGCATTGCAACGAATGGTACAAAACATTGCTATTTCAGCTGGTTCAGCCATTGGATCAACTTGCTTAAATCTTTGGTCAAATAATCTATTATTAGCTACTCGAATTGGCTGGGGAATTACACTCGTTCTTGTTATTTTCAGTTTAAAAGAACTAACACCATTTAAAATGACTAATAAAACAAAATAA","10.40","13.95","49488","MKEGIKMTKHLQDFFITVIAGMGMLLSTLDTGIINVALSFLRGQFQTTTNIASFTITGYTLALAISILPLGVLSDKFGKLKISYLGFVLFGLSSLFCGFANSIGWLITGRIIQGMGAAALQATSAALITTLVSEDRKNSAISILGVMIGLGPVLGPSLGGVLLSLNLWRFIFWINVPFALIVIICNHYLLTKVSEQTSEWTLDSLGTVLNASMLVCLLLGLSLLSKPHLLGISLILIIISFLIGIWFYRLECSKESALVNVKGLSENPRVLSYLFQTVAFGFASAMIFLLPPFIFEQLYHLGVGQTGFLVLGAPAGLVLFSRISGKINDGSKNKSFSHIGLGIIILSLIFLLLLTPSWPYLFLTLGLFIYGIGGGYFQPANMASIMLASPMKMQGSTGALQRMVQNIAISAGSAIGSTCLNLWSNNLLLATRIGWGITLVLVIFSLKELTPFKMTNKTK","1979532","For other 'mep' genes see SMu1913 (mepR).","possible multiple drug efflux pump MepA","Membrane, Cytoplasm, Extracellular","This protein is 73% similar to a previously sequenced protein, submitted to GenBank as MepA protein (gi|15625447) by Tao,L. and Tanzer,J.M.Many weak matches in gapped BLAST to MDR-type permeases and multidrug resistance proteins; e.g. residues 2-420 are 20% similar to MDR-type permease of Clostridium acetobutylicum (gi|15024395); residues 14-209 are 24% similar to multidrug resistance protein of Vibrio cholera (gi|15641422).SMu1914 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR001411
Family

Tetracycline resistance protein TetB
PR01036	$\"[110-130]T$ $\"[140-164]T$	TCRTETB

InterPro
IPR007114
Family

Major facilitator superfamily
PS50850	$\"[16-450]T$	MFS

InterPro
IPR011701
Family

Major facilitator superfamily MFS_1
PF07690	$\"[20-421]T$	MFS_1

noIPR
unintegrated

unintegrated
PTHR10074	$\"[10-206]T$ $\"[254-446]T$	PTHR10074
PTHR10074:SF57	$\"[10-206]T$ $\"[254-446]T$	PTHR10074:SF57
SSF103473	$\"[7-446]T$	SSF103473

noIPR
unintegrated

unintegrated
SSF52343	$\"[30-132]T$	SSF52343

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:56:11 2002","Tue Oct 8 13:56:11 2002","Tue Oct 8 13:56:11 2002","Wed Jan 2 14:00:31 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1915 is paralogously related (blast p-value < 1e-3) to SMu0624, a predicted hypothetical protein; ATP-binding protein; myosin-like.","Mon Apr 15 15:28:04 2002","","No significant hits to the NCBI PDB database.","SMU.2111c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 14:00:31 2002","24380443","","","","Tue Oct 8 13:56:11 2002","","1","","","SMU.2111c","" "SMu1916","1981932","1980235","1698","ATGATGAAAGAAAAGACACGTTTTAAACTGCACAAGGTTAAAAAGCAGTGGATGGCGATTGCCGTGACTAGTCTAGCTCTGGCTGCGATATTGTCAGGAGCTCACTTGACTCAGGCTGAGGAACAATCCGGCGGCGGTACTGACAGTAAGCCAAGACTGACAGCAACTGTACAGGAAAGCTCAGAACAACCAGTTACAGAAGCTCCAGCAGCTGATTCATCTGTAGAAAATAACAGTGCTAACGCTGTTAAAAGTTCTGAAACAGCAGAGGCAGCTGAAGTATCCGATGGAGGCAGAGCCAGCCAAACTGAAGCAGTAACAAACCAAACAAACTCTGAAGAGCACCATCCAGCAGAAAAAGCGACAGCCGTTTCTGGAGAAGCTCAGTCAGTGCAAAATGCTCCATCAGAAAATGCTGCCCAGCAGGAAACGGCTAAAACCGAACCAGCGACTGCTGCAGAAAATAATGACGCTGCCCCAACCAATAGCTTCTTTGAAAAAGATGGTAAATGGTACTACAAAAAGGCCGATGGACAGCTGGCAACCGGTTGGCAGACAATTGATGGAAAGCAGCTCTATTTCAACCAAGATGGTAGTCAGGTCAAAGGAGAAATTCATGTGGAGACAGGGGATCAAATCATTTATCATCCTGTTTTCATAAGTGATTCACCTTCAGTTTTGGAAGTCAATAAGATTTACTACTTTGATCCTGATAGTGGTGAACTCTGGAAGGATCGTTTTGTCTATTCTAGTTATGCAGATCCCCTCCATTATGAAAATATTAAACATGAAGGCTGGTTCTATCTTGGAGAAGATGGAAAGGCTGCTATCGGCTGGAGAACTATTGGCGGCAAAAAATACTATTTTGACACTAATGGTGTTCAAGTCAAAGGAAAGCTAATTAGTACAGATGGCAATTATAATCTAATTAGCCAGAAGTATGGCAAGAAATCTTTCCTAGATCCTGACACCGGTGAAGCTTGGACTAATCGTTTTGTCAATGCAAAGTATTATTTCTACAACTTTGCAGGATACGTCTCTACGACAGACTGGTTCTATATGGGAGCCGATGGTATCGGCGTGACCGACTGGCAAAAGATCGATGGTATGGATTACTATTTCGAACCTTCCAGTGGTATTCAGGTTAAAGGCGACATTGCTGAGCGTGATGGCAAGGTCTATTATTTAGATGAAGACAGTGGACAAGTTGTTAAGAATCGTTTTGGCACAACACCTGCCGAGCGTATCAGTACAGTTGAGGCTCGTTTCCCTAAAACTTATTATTTTGGAGCGGACGGCAGCCGCAAAGATCTAACTGGTTGGCAGATTATTGATGGTAAAACTTATTACTTTAAGGATGATCACAGCATAAAAGCAAAGTCAGAGTATAGTCAAATTGGTGGTTCTGTGCCTGATGACGGTTTTGCAGAGATTGATGGAGATGGTTACTTTTTTGATACTCAAGGTCAATTCGTAACGAATAGATTTGTCAGAAAATACGACTACAGTAATATTTGGTATTATTATGGAAGCGATGGCAAACGTGTATCAGGCTGGCAAACTATCGACGGTAAGCGCTACTACTTTAGCCAAGATGAAAAGACAAAGGGCCGTCAAATTAAAGGACAAACCATCACTATCGATGGTAAAGAATATACTTTTGACAAAGACAGCGGTGAAGTTATCAATAGTAACTAG","4.90","-18.77","63118","MMKEKTRFKLHKVKKQWMAIAVTSLALAAILSGAHLTQAEEQSGGGTDSKPRLTATVQESSEQPVTEAPAADSSVENNSANAVKSSETAEAAEVSDGGRASQTEAVTNQTNSEEHHPAEKATAVSGEAQSVQNAPSENAAQQETAKTEPATAAENNDAAPTNSFFEKDGKWYYKKADGQLATGWQTIDGKQLYFNQDGSQVKGEIHVETGDQIIYHPVFISDSPSVLEVNKIYYFDPDSGELWKDRFVYSSYADPLHYENIKHEGWFYLGEDGKAAIGWRTIGGKKYYFDTNGVQVKGKLISTDGNYNLISQKYGKKSFLDPDTGEAWTNRFVNAKYYFYNFAGYVSTTDWFYMGADGIGVTDWQKIDGMDYYFEPSSGIQVKGDIAERDGKVYYLDEDSGQVVKNRFGTTPAERISTVEARFPKTYYFGADGSRKDLTGWQIIDGKTYYFKDDHSIKAKSEYSQIGGSVPDDGFAEIDGDGYFFDTQGQFVTNRFVRKYDYSNIWYYYGSDGKRVSGWQTIDGKRYYFSQDEKTKGRQIKGQTITIDGKEYTFDKDSGEVINSN","1980253","For other 'gbp' genes see SMu0018 (gbpB); SMu0760 (gbpB) and SMu1273 (gbpC).From GenBank (gi:121725): In Streptococcus downei, glycosyltransferase I (GTF-I) is responsible for the production of extracellular glucans that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacerial cells and food debris. This secreted protein catalyzes the reaction: sucrose + (1,6-alpha-D-glucosyl)(N) = D-fructose + (1,6-alpha-D-glucosyl)(N+1). This protein is involved in dental caries. Note: GTF-I synthesizes water-insoluble glucans (alpha 1,3-linked glucose and some 1,6 linkages); GTF-S synthesizes water-soluble glucans (alpha 1,6-glucose); GTF-SI synthesizes both forms of glucans.From GenBank (gi:1351266): This protein also showed similarity to Toxin A of Clostridium difficile. Only after enteral delivery of this toxin, may pseudomembranous colitis develop.","glucan-binding protein","Extracellular","This protein was previously sequenced and submitted to GenBank as glucan-binding protein (gi:97986) by Banas, et al.Many moderate matches in gapped BLAST to glucosyltransferases of Streptococci species and to toxin A; e.g. residues 166-561 are 31% similar to glucosyltransferase of Streptococcus gordonii (gi1054877); residues 162-554 are 28% similar to toxin A of Clostridium difficile (gi1351266).SMu1916 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR002479
Repeat

Putative cell wall binding repeat
PF01473	$\"[162-180]T$ $\"[277-295]T$	CW_binding_1
PS51170	$\"[161-180]T$ $\"[181-200]T$ $\"[276-295]T$ $\"[361-380]T$ $\"[382-402]T$ $\"[438-457]T$ $\"[472-491]T$ $\"[493-515]T$ $\"[516-535]T$	CW

noIPR
unintegrated

unintegrated
G3DSA:2.10.270.10	$\"[168-250]T$ $\"[272-420]T$ $\"[438-563]T$	G3DSA:2.10.270.10
SSF69360	$\"[161-249]T$ $\"[266-333]T$ $\"[351-412]T$ $\"[428-563]T$	SSF69360

","No hits to the COGs database.","***** IPB003318 (Glucosyltransferase S precursor) with a combined E-value of 8.9e-13. IPB003318R 169-202 IPB003318A 2-20 IPB003318R 264-297 IPB003318R 504-537 IPB003318R 349-382 IPB003318R 284-317 IPB003318R 426-459","Residues 5-101 are 95% similar to a (TRANSFERASE PRECURSOR SIGNAL) protein domain (PD002249) which is seen in Q54447_STRMU.Residues 489-564 are 38% similar to a (GLUCAN-BINDING GBP PRECURSOR REPEAT) protein domain (PD236206) which is seen in Q54447_STRMU.Residues 231-293 are 38% similar to a (TRANSFERASE SIGNAL PRECURSOR) protein domain (PD285093) which is seen in O69397_STRMU.Residues 427-529 are 32% similar to a (TRANSFERASE SURFACE PSPC DEXTRANSUCRASE) protein domain (PD000439) which is seen in GTFB_STRMU.Residues 102-161 are 73% similar to a (GLUCAN-BINDING GBP PRECURSOR REPEAT) protein domain (PD098734) which is seen in Q54447_STRMU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Apr 24 10:48:00 2007","Wed Jan 2 13:55:57 2002","Tue Apr 24 10:48:00 2007","Wed Jan 2 13:55:57 2002","Wed Jan 2 13:55:57 2002","Wed Jan 2 13:55:57 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1916 is paralogously related (blast p-value < 1e-3) to SMu0914, a predicted glucosyltransferase-I; SMu0827,a predicted glucosyltransferase-S; SMu0915,a predicted glucosyltransferase-SI; SMu0700,a predicted BglB-like protein; SMu1947,a predicted conserved hypothetical protein and SMu0555,a predicted 40K cell wall protein precursor (sr 5' region); choline binding protein D.","Tue Apr 24 10:48:00 2007","","No significant hits to the NCBI PDB database.","SMU.2112c","","Residues 171 to 190 (E-value = 2.6e-08) place SMu1916 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 266 to 285 (E-value = 1.2e-07) place SMu1916 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)Residues 506 to 525 (E-value = 1.3e-07) place SMu1916 in the CW_binding_1 family which is described as Putative cell wall binding repeat (PF01473)","Tue Apr 24 10:48:00 2007","",""," Banas JA, Fountain TL, Mazurkiewicz JE, Sun K, Margaret Vickerman M.Streptococcus mutans glucan-binding protein-A affects Streptococcus gordonii biofilm architecture.FEMS Microbiol Lett. 2006 Dec 8; [Epub ahead of print] PMID: 17166223Banas JA, Hazlett KR, Mazurkiewicz JE. An in vitro model for studying the contributions of the Streptococcus mutans glucan-binding protein A to biofilm structure.Methods Enzymol. 2001;337:425-33.PMID: 11398448 Banas,J.A., Russell,R.R. and Ferretti,J.J.Sequence analysis of the gene for the glucan-binding protein of Streptococcus mutans Ingbritt.Infect. Immun. 58 (3), 667-673 (1990)PubMed: 2307516.Waterhouse JC, Russell RR.Dispensable genes and foreign DNA in Streptococcus mutans.Microbiology. 2006 Jun;152(Pt 6):1777-88.PMID: 16735740","Abo,H., Matsumura,T., Kodama,T., Ohta,H., Fukui,K., Kato,K. and Kagawa,H. Peptide sequences for sucrose splitting and glucan binding within Streptococcus sobrinus glucosyltransferase (water-insoluble glucan synthetase). J. Bacteriol. 173 (3), 989-996 (1991) PubMed: 1704006.","Tue Apr 24 10:48:00 2007","Sat Oct 26 17:25:27 2002","1","","","SMU.2112c","" "SMu1917","1982631","1982086","546","ATGAAATTCTATATCATTCGCCATGCAAAAGTTAATATGCGGTGGCCTAAAAAGTGTACTTCGGATGAATTTAATCAAGCCTGTAAAAAATATGATGGAGCAGATATTGTTGCTTTTCAAGGTTCCTTAGAGTTGCCCGTCTCTAATATATATACCAGTGAACTTATCCGAACCAAGCAAACAGCTCAGCAACTGTTTCCCTTGCAGTCTTATCAGATAGATAAAAGGCTCAATGAAGTTCCTTTAAAAGCAGCCTTTTCTTCTAAGATAAAGCTGCCCTTGATCTTTTGGAATATTCTAGGTAGATTGCAGTGGCTCTTTAATTCTAGTAAACAAGAGGGAATCAAAGCCAGCAAGGAAAGAGCAGAAAAGTTTTGTGATGATTTAATTTATAAGGGCGAAGATGCTATCCTTATCACTCATGGTTTTTTTATGATAACTCTATTAAAAGAATTGAAAAAGAGAGGATTCATTGAAAAAGATAATGGCTTCAATTTTGACAATTTGCAAGTAATAGAAGTAAAAAAAAGACTGTTAGTTTATTAA","10.30","10.33","21162","MKFYIIRHAKVNMRWPKKCTSDEFNQACKKYDGADIVAFQGSLELPVSNIYTSELIRTKQTAQQLFPLQSYQIDKRLNEVPLKAAFSSKIKLPLIFWNILGRLQWLFNSSKQEGIKASKERAEKFCDDLIYKGEDAILITHGFFMITLLKELKKRGFIEKDNGFNFDNLQVIEVKKRLLVY","1982104","","conserved hypothetical protein","Cytoplasm","One weak match in gapped BLAST to unknown protein of B.halodurans; e.g. residues 1-157 are 30% similar to residues 1-159 (gi|15613299).SMu1917 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR013078
Domain

Phosphoglycerate mutase
PF00300	$\"[2-148]T$	PGAM

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1240	$\"[1-157]T$	G3DSA:3.40.50.1240
SSF53254	$\"[2-175]T$	SSF53254

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-157 are 30% similar to a (PROTEOME BH0736 COMPLETE) protein domain (PD306876) which is seen in Q9KEW3_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:54:23 2002","Wed Jan 2 13:31:39 2002","Wed Jan 2 13:31:39 2002","Wed Jan 2 13:31:39 2002","","Wed Jan 2 13:31:39 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1917 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:54:23 2002","","No significant hits to the NCBI PDB database.","SMU.2113c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 13:31:39 2002","24380445","","","","","","1","","","SMU.2113c","" "SMu1918","1983071","1982697","375","ATGCATTATTCCATTGGAAAATTTTCAAAATTAACGCGTCTTAGCGTTCATACTCTGAGGTACTATGAAAATGAAGGCTTATTGAGACCGCAAAGAGATGGCAGCAATAGGAGGTATTACAATGAAAGTGATTATCAATGGCTGCTCTTCATCTTACGCTTGAAAGCTGTTGGTATGCCCATAAAAGAAATAAAACATTATTCAGATCTTCGAGAAAAAGGGGAAAGTACTTATTTGGAGAGACTAATCCTTTTAGAGCATCATTTGCAGGTTTTAGATAATAATATTGCTGATTTATTGGACAACAGAGAAAAATTAATTGAAAAGATACATTTTTACCAAGAGAAGTTAACTTTGAAAAAAGACTTAAATTGA","9.90","4.44","15020","MHYSIGKFSKLTRLSVHTLRYYENEGLLRPQRDGSNRRYYNESDYQWLLFILRLKAVGMPIKEIKHYSDLREKGESTYLERLILLEHHLQVLDNNIADLLDNREKLIEKIHFYQEKLTLKKDLN","1982715","For other 'rme' genes see SMu0619 (rmeA).","probable transcriptional regulator, MerR family","Cytoplasm","Several moderate matches in gapped BLAST to transcriptional regulators, MerR family; e.g. residues 1-117 are 43% similar to transcription regulator of Listeria monocytogenes (gi|16802131); residues 1-117 are 47% similar to transcription regulator of Clostridium acetobutylicum (gi|15004881).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0427 (1e-10).","

InterPro
IPR000551
Domain

Bacterial regulatory protein, MerR
PR00040	$\"[4-15]T$ $\"[15-28]T$ $\"[38-58]T$	HTHMERR
PF00376	$\"[4-40]T$	MerR
SM00422	$\"[3-71]T$	HTH_MERR
PS00552	$\"[6-28]?$	HTH_MERR_1
PS50937	$\"[2-70]T$	HTH_MERR_2

InterPro
IPR009061
Domain

Putative DNA binding
SSF46955	$\"[3-115]T$	Putativ_DNA_bind

InterPro
IPR015358
Domain

Transcription regulator MerR, DNA binding
PF09278	$\"[45-109]T$	MerR-DNA-bind

noIPR
unintegrated

unintegrated
G3DSA:1.10.1660.10	$\"[3-115]T$	G3DSA:1.10.1660.10

","BeTs to 7 clades of COG0789COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG0789 is a----q-CEBRHuj-------Number of proteins in this genome belonging to this COG is 9","***** IPB000551 (Bacterial regulatory proteins, MerR family) with a combined E-value of 3.4e-25. IPB000551A 5-26 IPB000551B 27-68","Residues 44-113 are 38% similar to a (REGULATOR PROTEOME TRANSCRIPTIONAL) protein domain (PD072156) which is seen in Q9RDQ6_STRCO.Residues 42-115 are 40% similar to a (TRANSCRIPTIONAL REGULATOR REGULATION) protein domain (PD406858) which is seen in Q9CE68_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 16:07:43 2002","Wed Jan 2 13:20:40 2002","Wed Jan 2 13:20:26 2002","Mon Apr 8 11:16:25 2002","Wed Jan 2 13:13:16 2002","Wed Jan 2 13:13:16 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1918 is paralogously related (blast p-value < 1e-3) to SMu0619, SMu0328, SMu1630, SMu0477, SMu0144, SMu0663, SMu1868, and SMu1174, all predicted transcriptional regulators.","Mon Apr 15 15:33:46 2002","","No significant hits to the NCBI PDB database.","SMU.2114c","","Residues 4 to 40 (E-value = 2.7e-14) place SMu1918 in the MerR family which is described as MerR family regulatory protein (PF00376)","Wed Jan 2 13:13:16 2002","24380446","","","","","","1","","","SMU.2114c","" "SMu1919","1983150","1983905","756","ATGATGTATTCAAAAAATTACGTTTGTATTACTGGAGCGAGCTCTGGTATTGGCTTAGAAACTGCAAAAGCATTTGCAAGTCTAGAAAACAATCTTATTCTAGTCGCCAGACGTCAGGAGCGATTAGAGAAACTCAAAGAGGAGCTTCTTCTCAGTTTCCCAAAGCTGGATATTGTTGTCAAATCAGTCGACCTTTCTATTTCCGAGAATGCCTTTAAACTTTATCAGGAATTAAAATCGTATCAGATCTTAACTTGGATTAATAATGCTGGTTTTGGTAATTATGATAGTGTGGATCATCAAAACCTTGATAAAATCACTAAAATGCTTCATCTCAATATCGAGTCCTTGACTATTTTATCCAGTCTTTATGTAAAGGACTATAAAAATGTAGAAGGTACTCAGTTGATTAATCTTTCTTCTAGAGGCGGTTATATGTTAGTCAAAAATGCTGTAACTTACTGTGCCAGTAAATTCTACGTCAGTGCCTTCACAGAAGGACTGGCTCTGGAATTGGCAGCCAATCACTGTCCTTTAAAAGCCAAAGTTTTGGCTCCTGCTGCAACAAAAAGCGAATTTGGACAGGTTGCTGCTGATACAGATAGTTATGATTATGACAAGCATTTTACCACCTATCATACTAGTAAAGAAATGGCTGATTTTCTAATCGAATTATACTATAGTGATAAAATTGTTGGATTAGTAGACATCAATGATTTCGACTTTAAATTGAGTGAGCCGCTGTTTAAACACTGA","6.00","-3.69","28268","MMYSKNYVCITGASSGIGLETAKAFASLENNLILVARRQERLEKLKEELLLSFPKLDIVVKSVDLSISENAFKLYQELKSYQILTWINNAGFGNYDSVDHQNLDKITKMLHLNIESLTILSSLYVKDYKNVEGTQLINLSSRGGYMLVKNAVTYCASKFYVSAFTEGLALELAANHCPLKAKVLAPAATKSEFGQVAADTDSYDYDKHFTTYHTSKEMADFLIELYYSDKIVGLVDINDFDFKLSEPLFKH","1983917","","probable oxidoreductase (probable short-chain dehydrogenase)","Cytoplasm","Several matches in gapped BLAST to oxidoreductases and short-chain dehydrogenases; e.g. residues 5-251 are 55% similar to similar to oxidoreductase of Listeria innocua (gi|16799879); residues 8-197 are 34% similar to probable short-chain dehydrogenase of Clostridium acetobutylicum (gi|15896244).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0348 (2e-10).","

InterPro
IPR002198
Family

Short-chain dehydrogenase/reductase SDR
PR00080	$\"[81-92]T$ $\"[134-142]T$ $\"[154-173]T$	SDRFAMILY
PTHR19410	$\"[1-173]T$	ADH_short_C2
PF00106	$\"[6-173]T$	adh_short
PS00061	$\"[141-169]?$	ADH_SHORT

InterPro
IPR002347
Family

Glucose/ribitol dehydrogenase
PR00081	$\"[7-24]T$ $\"[81-92]T$ $\"[128-144]T$ $\"[154-173]T$	GDHRDH

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.720	$\"[3-241]T$	G3DSA:3.40.50.720
PTHR19410:SF38	$\"[1-173]T$	PTHR19410:SF38
SSF51735	$\"[4-246]T$	SSF51735

","BeTs to 5 clades of COG0300COG name: Short-chain dehydrogenases of various substrate specificitiesFunctional Class: RThe phylogenetic pattern of COG0300 is ----y--ceBRhuj-------Number of proteins in this genome belonging to this COG is 3","***** IPB002198 (Short-chain dehydrogenase/reductase (SDR) superfamily) with a combined E-value of 9.3e-07. IPB002198 134-169","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 16:06:55 2002","Wed Jan 2 13:12:09 2002","Wed Jan 2 13:12:09 2002","Mon Apr 15 15:36:39 2002","Wed Jan 2 13:12:09 2002","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1919 is paralogously related (blast p-value < 1e-3) to SMu1340, a predicted oxidoreductase; SMu1586,a predicted beta-ketoacyl-ACP reductase; SMu0949,a predicted oxidoreductase, short-chain dehydrogenase /reductase and SMu1207,a predicted acetoin reductase.","Mon Apr 15 15:36:39 2002","","No significant hits to the NCBI PDB database.","SMU.2115","","Residues 8 to 248 (E-value = 3.7e-10) place SMu1919 in the adh_short family which is described as short chain dehydrogenase (PF00106)","Wed Jan 2 13:12:09 2002","24380447","","Abranches J, Lemos JA, Burne RA.,Osmotic stress responses of Streptococcus mutans UA159.FEMS Microbiol Lett. 2006 Feb;255(2):240-6.PMID: 16448501","","","","1","","","SMU.2115","" "SMu1920","1984357","1985508","1152","ATGGATAAAGATCCAGTTATTGAATTTAAAGAGGTTAACAAAATTTATGGAGATAATGTTGCTGTTAAGCATATCAATTTAAAAATTATGGCAGGTGAATTTGTCTGCTTGATTGGTACCAGCGGATCCGGTAAAACAACAATTCTACGCATGATTAACCGTATGTTAAAACCAAGCAATGGGAAAATTTTTATCAAAGGGGAAGAAATTTCTGATCTCAACCCTGTTCAACTCAGACGCAAGATTGGTTATGTTATTCAAAATATCGGCCTCATGCCACATATGACAATTTATGAGAATATTACTCTGGTTCCGAAATTATTAAAATGGTCAGAAGATAAGAAAAAAGCTAAAGCCAAAGAACTTATAAAGCTTGTTGAATTGCCTGAAGATTTCTTGGATCGCTACCCTTACGAATTGTCAGGCGGACAACAACAGCGTATTGGTGTTGTCAGAGCTCTAGCTGCTGATCAAGACATTATTTTGATGGATGAACCTTTTGGTGCTTTGGATCCTATCACCCGCGAAGGGCTTCAAGATTTGGTGAAATCTTTACAAGAAAAAACAGGAAAAACGATTGTCTTGGTCACTCATGATATGGACGAAGCCCTAAAGCTAGCAACCAAGATTGTCGTTATGGATAAAGGTCATATGGTTCAACAAGCCAATCCGACCGAATTGTTACGCCACCCCGCAACCGCATTTGTTAAAAAGATGATTGGTGAAGACCGACTCATTCAAGCACGCGCTGATGTAACGCCGGTTAAAAACATCATGCTAAAAGACCCCGTTTCCATTGCACCTGATAAATCTCTCAATGATGCTATCTCACTCATGCGTCAAAAACGTGTTGACTCTCTTTTAGTTACAGATAAGGATAATAAACTACTCGGCATGATTGATGTTGAATCCTTAAATAATAACTACAAACAAAACCTTGTTGTTGCCGATATCTTAAATAAAATCAGTTTCTACTTGGAAGAAGATCAACTGCTGCGCGACACAGCCCATCGTATCTTAAAACGCGGACTTAAATATGTACCGGTTATTGATAAAGAATGGCATTTAAAGGGAATCGTGACGCGATCATCTCTGGTAGATATGCTTTATGATATTATTTGGGGCAATCAAGATACGGAGGAAACATTATGA","8.40","2.67","43405","MDKDPVIEFKEVNKIYGDNVAVKHINLKIMAGEFVCLIGTSGSGKTTILRMINRMLKPSNGKIFIKGEEISDLNPVQLRRKIGYVIQNIGLMPHMTIYENITLVPKLLKWSEDKKKAKAKELIKLVELPEDFLDRYPYELSGGQQQRIGVVRALAADQDIILMDEPFGALDPITREGLQDLVKSLQEKTGKTIVLVTHDMDEALKLATKIVVMDKGHMVQQANPTELLRHPATAFVKKMIGEDRLIQARADVTPVKNIMLKDPVSIAPDKSLNDAISLMRQKRVDSLLVTDKDNKLLGMIDVESLNNNYKQNLVVADILNKISFYLEEDQLLRDTAHRILKRGLKYVPVIDKEWHLKGIVTRSSLVDMLYDIIWGNQDTEETL","1985520","For other components see SMu1921 (MSD1); SMu1923 (MSD2) and SMu1922 (SBP1)For other 'opc' genes see SMu1923 (opcD); SMu1922 (opcC) and SMu1921 (opcB).From GenBank (gi:7387983): In B.subtilis, this protein is amember of a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine, and choline. It is probably responsible for energy coupling to the transport system. Belongs to the ATP-binding transport protein family. It contains to CBS domains.","glycine betaine / carnitine / choline ABC transporter, ATP-binding protein, opuCA","Cytoplasm, Membrane","Numerous strong matches in gapped BLAST to glycine betaine/carnitine/choline ABC transporter; e.g. residues 6-380 are 52% similar to this ATP-binding protein of Bacillus subtilis (gi7387983); residues 6-375 are 57% similar to ATPase OpuCA of Listeria monocytogenes (gi9651975).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0244 (1e-149).","

InterPro
IPR000644
Domain

Cystathionine-beta-synthase
PF00571	$\"[257-370]T$	CBS
SM00116	$\"[262-310]T$ $\"[322-370]T$	CBS

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[139-182]T$	ABC_transporter
PF00005	$\"[32-216]T$	ABC_tran
PS00211	$\"[140-154]T$	ABC_TRANSPORTER_1
PS50893	$\"[7-240]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[31-217]T$	AAA

InterPro
IPR005892
Family

Glycine betaine/L-proline transport ATP-binding subunit
TIGR01186	$\"[14-375]T$	proV

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-249]T$	G3DSA:3.40.50.300
PTHR19222	$\"[7-247]T$	PTHR19222
PTHR19222:SF48	$\"[7-247]T$	PTHR19222:SF48
SSF52540	$\"[5-264]T$	SSF52540
SSF54631	$\"[249-305]T$ $\"[311-371]T$	SSF54631

","BeTs to 5 clades of COG1125COG name: ABC-type proline/glycine betaine transport systems, ATPase componentsFunctional Class: EThe phylogenetic pattern of COG1125 is a-------EBr-uj--o----Number of proteins in this genome belonging to this COG is 3","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.2e-33. IPB001140A 21-67 IPB001140B 137-175 IPB001140C 193-222","Residues 226-369 are 27% similar to a (TRANSPORT ATP-BINDING OPUAA CBS) protein domain (PD021831) which is seen in OPAA_BACSU.Residues 255-319 are 46% similar to a (COMPLETE PROTEOME CHANNEL CBS DOMAIN TRANSPORT REPEAT) protein domain (PD022727) which is seen in OPBA_BACSU.Residues 183-219 are 62% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER PROTEOME COMPLETE) protein domain (PD281472) which is seen in Q9KHT9_LISMO.Residues 301-380 are 47% similar to a (TRANSPORT ATP-BINDING AMINO-ACID DOMAIN) protein domain (PD067635) which is seen in OPCA_BACSU.Residues 190-224 are 68% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in YEHX_ECOLI.Residues 324-369 are 67% similar to a (COMPLETE PROTEOME DEHYDROGENASE DOMAIN) protein domain (PD000251) which is seen in Q9KHT9_LISMO.Residues 79-137 are 52% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD007166) which is seen in Q9KHT9_LISMO.Residues 17-226 are 24% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 22-70 are 63% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in OPBA_BACSU.Residues 139-180 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9KHT9_LISMO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Jul 24 16:58:15 2006","Mon Oct 28 15:30:58 2002","Mon Jul 24 16:58:15 2006","Mon Apr 8 11:13:46 2002","Wed Jan 2 12:39:24 2002","Wed Jan 2 12:39:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1920 is paralogously related (blast p-value < 1e-3) to SMu1003, SMu0971, SMu0884, SMu0731, SMu0517, SMu1380, SMu0594, SMu0218, SMu1428, SMu0805, SMu0849, SMu0418, SMu1079, SMu1762, SMu1246, SMu1231, SMu1288, SMu0235, SMu0786, SMu0390, SMu1036, SMu1950, SMu1949, SMu1518, SMu1001, SMu1023, SMu1068, SMu1210, SMu0374, SMu1751, SMu1037, SMu0335, SMu0916, SMu1710, SMu0944, SMu0976, SMu1517, SMu0258, SMu0824, SMu0836, SMu0950, SMu0596, SMu0907, SMu1649, SMu1064, SMu0234, SMu1757, SMu1050, SMu1316, SMu0752, SMu0475, SMu0476, SMu0825, SMu1724, SMu1093, SMu0216, SMu0164, SMu1410, SMu1545, SMu0986, SMu0666, SMu0987, SMu0837, SMu0823, SMu1065, SMu1959, SMu1811, SMu0024, SMu0224, SMu1306, SMu0729, SMu1202, and SMu1516, all with ATP-binding capabilities.","Mon Apr 15 15:37:14 2002","Mon Jul 24 16:58:15 2006","pdb1G291 Chain 1, Malk >gi12084695pdb1G292 Chain 2, Malk 146 5e-036pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 134 2e-032","SMU.2116","","Residues 32 to 216 (E-value = 1.1e-68) place SMu1920 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 257 to 310 (E-value = 2.5e-12) place SMu1920 in the CBS family which is described as CBS domain (PF00571)Residues 317 to 370 (E-value = 1.9e-06) place SMu1920 in the CBS family which is described as CBS domain (PF00571)","Mon Jul 24 16:58:15 2006","24380448","","","Kappes,R.M., Kempf,B., Kneip,S., Boch,J., Gade,J., Meier-Wagner,J. and Bremer,E. Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis. Mol. Microbiol. 32 (1), 203-216 (1999) PubMed: 10216873.","Mon Oct 28 15:28:35 2002","Wed Jan 2 12:39:24 2002","1","","","SMU.2116","630" "SMu1921","1985505","1986137","633","ATGAGCGAATTTCTAGCACAATATGGTGGTGAGCTGCTCATAAAAACATGGGAGCAAATTTATATCTCCGCCATTGCACTTTGTCTTGGAATCATTGTTGCTGTTCCAATAGGAGTGGCTTTGACACGATTTCCTAAATTAGCAAAAATTTTCATTGGTATCGCCAGTATCTTGCAGACAATTCCCAGTTTGGCTCTGTTAGCTATCATGATTCCCTTTTTTGGCATCGGAAGAACCCCAGCCATTATTGCTTTGTTTGTTTATTCTTTATTGCCAATCATGAGAAATACCTATATCGGAATGAACAATGTGGATCCTATCTTAAAAGACAGTGCCAAGGGAATGGGAATGAAACCAATCCAATCTATTTTTCAAGTTGAGCTTCCTTTGGCAGTCCCTGTCATAATGACAGGGATTAGATTATCAGCTATCTATGTCATTGCTTGGGCAACTTTAGCCTCTTATATTGGAGCAGGCGGGCTTGGAGACTTGATTTTCAGCGGCTTAAGTCTGTTCCAACCGTCTCTTATTATCGGTGGAACAATTCCAGTTATCCTCCTTTCTCTCATCGTTGACTATCTTCTAGGACGCCTTGAAAATTATTTAACACCACGACAAAAGAGGAGTTTATAA","10.30","4.94","22678","MSEFLAQYGGELLIKTWEQIYISAIALCLGIIVAVPIGVALTRFPKLAKIFIGIASILQTIPSLALLAIMIPFFGIGRTPAIIALFVYSLLPIMRNTYIGMNNVDPILKDSAKGMGMKPIQSIFQVELPLAVPVIMTGIRLSAIYVIAWATLASYIGAGGLGDLIFSGLSLFQPSLIIGGTIPVILLSLIVDYLLGRLENYLTPRQKRSL","1986149","For other components see SMu1920 (NBD1); SMu1923 (MSD2) and SMu1922 (SBP1).For other 'opc' genes see SMu1923 (opcD); SMu1922 (opcC) and SMu1920 (opcA).From GenBank (gi:7404428): In B.subtilis, this protein is a member of a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine, and choline; probably responsible for the translocation of substrate across the membrane. It is an integral membrane protein with integral membrane components of other binding-protein-dependent transport systems.","glycine betaine / carnitine / choline ABC transporter permease","Membrane, Cytoplasm","Many moderate matches in gapped BLAST to glycine betaine/carnitine/choline ABC transporter permease (membrane protein) opuBB; e.g. residues 1-205 are 58% similar to this ABC transporter of Bacillus subtilis (gi7387982); residues 4-192 are 60% similar to OpuCB of Listeria monocytogenes (gi12003349).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0243 (6e-92).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[16-208]T$	BPD_transp_1
PS50928	$\"[16-195]T$	ABC_TM1

","BeTs to 6 clades of COG1174COG name: Proline/glycine betaine ABC-type transport systems, permease componentsFunctional Class: EThe phylogenetic pattern of COG1174 is A-------EBR-uj--o----Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 156-208 are 60% similar to a (PERMEASE OPUCB AMINO COMPLETE) protein domain (PD412420) which is seen in Q9KHT8_LISMO.Residues 93-157 are 49% similar to a (TRANSPORT PERMEASE COMPLETE TRANSMEMBRANE) protein domain (PD001159) which is seen in Q9HXC5_PSEAE.Residues 15-92 are 35% similar to a (PROTEOME COMPLETE PRO -2) protein domain (PD240429) which is seen in O29282_ARCFU.Residues 144-205 are 59% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE) protein domain (PD413293) which is seen in OPCB_BACSU.Residues 16-91 are 41% similar to a (TRANSPORT PERMEASE ABC COMPLETE) protein domain (PD068741) which is seen in Q9HXC3_PSEAE.Residues 10-141 are 24% similar to a (PROTEOME COMPLETE OF ABC) protein domain (PD296127) which is seen in Q9I1G8_PSEAE.Residues 110-207 are 32% similar to a (PROTEOME SYSTEM COMPLETE TRANSPORT) protein domain (PD057558) which is seen in O69723_MYCTU.Residues 39-92 are 62% similar to a (TRANSPORT PERMEASE PROTEOME COMPLETE) protein domain (PD388919) which is seen in Q9KHT8_LISMO.Residues 22-89 are 40% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD321195) which is seen in Q9RZ17_DEIRA.Residues 58-150 are 30% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD400838) which is seen in Q9KDK3_BACHD.Residues 59-141 are 31% similar to a (MEMBRANE PROTEOME COMPONENT SYSTEM) protein domain (PD414592) which is seen in Q9KYY5_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 7 09:38:40 2006","Thu Sep 7 09:38:40 2006","Thu Sep 7 09:38:40 2006","Mon Apr 8 11:13:21 2002","","Wed Jan 2 12:14:08 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1921 is paralogously related (blast p-value < 1e-3) to SMu1002, a predicted phosphate ABC transporter; SMu1923,a predicted glycine betaine / carnitine / choline ABC transporter permeases (membrane p); SMu0970, a predicted glycine-betaine binding permease protein; SMu1038,a predicted phosphate ABC transporter (permease protein); SMu0595,a predicted ABC transporter,permease protein/possible taurine transport system permease protein; SMu1761, a predicted amino acid ABC transport permease; and SMu1039,a predicted phosphate ABC transporter (permease protein).","Mon Apr 15 15:42:59 2002","","No significant hits to the NCBI PDB database.","SMU.2117","","Residues 16 to 208 (E-value = 2.5e-27) place SMu1921 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Jan 2 12:14:08 2002","24380449","","","Kappes,R.M., Kempf,B., Kneip,S., Boch,J., Gade,J., Meier-Wagner,J. and Bremer,E. Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis. Mol. Microbiol. 32 (1), 203-216 (1999) PubMed: 10216873.","","Wed Jan 2 12:23:58 2002","1","","","SMU.2117","888" "SMu1922","1986139","1987074","936","ATGAAAAAAATAACTTATTTTTTAATCATTACTTTGATGATTCCTATACTTATGCTCACAAGTTGTCATTCTAATAATAAGGCCAAAACTAACACTAATACTTCGGGCAACATTAAAATTGCGGCCATGAGTACAACAGAATCCAGTATTATGGCCAATATGATCAGTGAATTGATCAATCACGAATTAGGTTATAAAACAACCTTGGTATCTAACCTTGGTTCTACAAATGTTGTGCATCAAGCTTTGATACGAAATGATGCAGACATTGCAGCTACTCGTTATACAGGAACTGATTTAACAGGCACACTCAATTTATCTGCTGAAAAGGATCACACTAAAGCCGCTAAAATTGTCAAAAAGGCATTTGCCAAACGCTTTGACCAAACTTGGTTCCCAAGTTATGGCTTCGCTGATACCTATGCTTTCATGGTCACCAGCAAGTTTGCTCAACAAAATCATCTCAAGACTTTTTCCGATTTACAAAAGATATCAACAACAGCTAAAGCCGGTGTTGATAGCACTTGGATGAAACGTGTCGGTGATGGTTATAAAGATTTCAGTCGTGCTTATGGTTTTTCATTTAAACATATTTACCCCATGCAGATTGGCCTTGTCTATGATGCTGTTGAAAATAATAAAATGCAGGTCGTTTTAGGCTATTCTACAGATGGTCGTATTCAGAGTTACGATCTTACGATACTGGAAGATAATAAACATTTCTTCCCTCCTTATGATGCCTCAATGGTTGTTAATAATCGTATCTTAAGAAAATATCCAAAACTAAAGACCTTATTACACCGTTTAGATGGTAAGATTGACCTTAAAACCATGCAAAAACTGAACTATCAAGTCGATGACCAATTACTTGAACCATCAGTAGTTGCTCATCAATTTCTGAAAAAACATGATTATTTCCGAAAGGGTGATAACTAA","10.30","14.35","35292","MKKITYFLIITLMIPILMLTSCHSNNKAKTNTNTSGNIKIAAMSTTESSIMANMISELINHELGYKTTLVSNLGSTNVVHQALIRNDADIAATRYTGTDLTGTLNLSAEKDHTKAAKIVKKAFAKRFDQTWFPSYGFADTYAFMVTSKFAQQNHLKTFSDLQKISTTAKAGVDSTWMKRVGDGYKDFSRAYGFSFKHIYPMQIGLVYDAVENNKMQVVLGYSTDGRIQSYDLTILEDNKHFFPPYDASMVVNNRILRKYPKLKTLLHRLDGKIDLKTMQKLNYQVDDQLLEPSVVAHQFLKKHDYFRKGDN","1987086","For other components see SMu1920 (NBD1), SMu1921 (MSD1) and SMu1923 (MSD2).For other 'opc' genes see SMu1923 (opcD); SMu1921 (opcB) and SMu1920 (opcA).From GenBank (gi:7387985): In B.subtilis, this protein is a member of a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine, and choline. It is attached to the membrane by a lipid anchor.Note: The first 37 N-terminal amino acids match to no other protein.","glycine betaine/carnitine/choline ABC transporter, substrate-binding protein","Membrane, Extracellular","Many strong matches in gapped BLAST to glycine betaine/carnitine/choline-binding ABC transporter protein; e.g. residues 38-306 are 56% similar to this protein of Bacillus subtilis (gi7387985); residues 38-306 are 54% similar to substrate binding protein of Listeria monocytogenes (gi16803466).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0242 (1e-112).","

InterPro
IPR007210
Domain

Substrate-binding region of ABC-type glycine betaine transport system
PF04069	$\"[36-302]T$	OpuAC

noIPR
unintegrated

unintegrated
G3DSA:3.40.190.120	$\"[140-244]T$	G3DSA:3.40.190.120
PS51257	$\"[1-22]T$	PROKAR_LIPOPROTEIN
SSF53850	$\"[36-307]T$	SSF53850

","BeTs to 5 clades of COG1732COG name: Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)Functional Class: EThe phylogenetic pattern of COG1732 is a-------eBr-uj-------Number of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 38-302 are 56% similar to a (COMPLETE PROTEOME TRANSPORTER ABC) protein domain (PD009904) which is seen in OPCC_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 1 14:28:59 2007","Thu Mar 1 14:28:59 2007","Thu Sep 28 15:02:02 2006","Mon Apr 8 11:12:46 2002","","Wed Jan 2 12:04:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1922 is paralogously related (blast p-value < 1e-3) to SMu1002, a predicted phosphate ABC transporter.","Mon Apr 15 15:44:09 2002","","No significant hits to the NCBI PDB database.","SMU.2118","","Residues 37 to 307 (E-value = 7.9e-89) place SMu1922 in the OpuAC family which is described as Substrate binding domain of ABC-type glycine betaine transport system (PF04069)","Wed Jan 2 12:04:07 2002","24380450","","","Kappes,R.M., Kempf,B., Kneip,S., Boch,J., Gade,J., Meier-Wagner,J. and Bremer,E. Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis. Mol. Microbiol. 32 (1), 203-216 (1999) PubMed: 10216873.","","Wed Jan 2 12:11:52 2002","1","","","SMU.2118","" "SMu1923","1987083","1987739","657","ATGAGTATGGCACAGCAATTAATTTATTATTTCAACCATAATAGTACCTATGTCTTGGCACAATTTTTACGGCATTTCTTAATATCCATTTATGGTGTACTCCTTGCTGCTCTTGTTGGTATTCCAATGGGCATACTAATTGCTAAAAGAGGGAAACTCAAAGGGGTTGTCATGGGAGCTGCTAATGTCATTCAAACGATTCCCTCTCTAGCCATGATTTCTATTATCATGCTAGGACTTGGCTTAGGCACTAAAACAGTCATTGCAACAGTATTCTTATATTCTTTACTTCCTATTATCGGTAATACCTATACCGGTATTAAAAATGTTGATGGTGATCTCGTTGATGCTGCTAAAGGAATGGGAATGACTAATAGACAGCAATTATTGATGGTTGAGCTGCCTTTATCTTTGTCAGTTATTATGGCCGGCATTCGCAACGCTCTGGTCGTTGCTGTAGGAATAACAGCCATTGGCGCCTTTGTTGGTGGCGGTGGTCTCGGAGATATCATTATCCGTGGTACCAATGCCACTAACGGCGGTGCTATTATTTTGGCTGGTTCTATACCAACTGCTTTTATGGCTGTTGTCTCTGATTTGATTCTTGGCATTATTCAACGCTATCTAGAACCCAAAGGTATATCAACTAACCAATAA","10.60","6.46","22760","MSMAQQLIYYFNHNSTYVLAQFLRHFLISIYGVLLAALVGIPMGILIAKRGKLKGVVMGAANVIQTIPSLAMISIIMLGLGLGTKTVIATVFLYSLLPIIGNTYTGIKNVDGDLVDAAKGMGMTNRQQLLMVELPLSLSVIMAGIRNALVVAVGITAIGAFVGGGGLGDIIIRGTNATNGGAIILAGSIPTAFMAVVSDLILGIIQRYLEPKGISTNQ","1987751","For other components see SMu1920 (NBD1); SMu1921 (MSD1) and SMu1922 (SBP1). For other 'opc' genes see SMu1922 (opcC); SMu1921 (opcB) and SMu1920 (opcA).From GenBank (gi:7387986): In B.subtilis, this protein is involved in a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine, and choline; probably responsible for the translocation of the substrate across the membrane. This is an integral membrane protein with integral membrane components of other binding-protein-dependent transport systems. It belongs to the CYSTW subfamily.","ABC transport betaine/carnitine/choline permease","Membrane, Cytoplasm","Numerous moderate matches in gapped BLAST to betaine/carnitine/choline ABC transporter; e.g. residues 1-211 are 52% similar to this transporter of Bacillus subtilis (gi7387986); residues 1-211 are 51% similar to this transporter of Listeria monocytogenes (gi16803465).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0241 (4e-78).","

InterPro
IPR000515
Family

Binding-protein-dependent transport systems inner membrane component
PF00528	$\"[22-215]T$	BPD_transp_1
PS50928	$\"[22-202]T$	ABC_TM1

","BeTs to 6 clades of COG1174COG name: Proline/glycine betaine ABC-type transport systems, permease componentsFunctional Class: EThe phylogenetic pattern of COG1174 is A-------EBR-uj--o----Number of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","Residues 99-147 are 65% similar to a (TRANSPORT PERMEASE COMPLETE TRANSMEMBRANE) protein domain (PD001159) which is seen in Q9KHT6_LISMO.Residues 23-98 are 36% similar to a (PROTEOME COMPLETE PRO -2) protein domain (PD240429) which is seen in O29282_ARCFU.Residues 23-97 are 45% similar to a (TRANSPORT PERMEASE ABC COMPLETE) protein domain (PD068741) which is seen in Q9HXC3_PSEAE.Residues 1-44 are 59% similar to a (TRANSPORT PERMEASE AMINO-ACID OPUCD) protein domain (PD334575) which is seen in OPCD_BACSU.Residues 45-98 are 55% similar to a (TRANSPORT PERMEASE PROTEOME COMPLETE) protein domain (PD388919) which is seen in Q9KHT6_LISMO.Residues 45-97 are 58% similar to a (TRANSPORT PERMEASE TRANSMEMBRANE) protein domain (PD411605) which is seen in OPCD_BACSU.Residues 25-89 are 38% similar to a (PROTEOME AMINO COMPLETE ACID) protein domain (PD321195) which is seen in Q9RZ17_DEIRA.Residues 175-211 are 64% similar to a (TRANSPORT PERMEASE AMINO-ACID OPUCD) protein domain (PD019528) which is seen in OPCD_BACSU.Residues 53-146 are 29% similar to a (MEMBRANE PROTEOME COMPONENT SYSTEM) protein domain (PD414592) which is seen in Q9KYY5_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Sep 28 09:52:58 2006","Thu Sep 28 09:52:58 2006","Thu Sep 28 09:52:58 2006","Mon Apr 8 11:12:15 2002","","Wed Jan 2 11:49:53 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1923 is paralogously related (blast p-value < 1e-3) to SMu1921 , a predicted glycine betaine/carnitine/choline ABC transporter permease (membrane p); SMu1002,a predicted phosphate ABC transporter; SMu0970,a predicted glycine-betaine binding permease protein; SMu0885 and SMu0886,both predicted spermidine/putrescine ABC transporters (permease protein); SMu1038 and SMu1382, both predicted amino acid ABC transporters, permease proteins; SMu0595,a predicted ABC transporter, permease protein/possible taurine transport system permease;SMu1080,a predicted amino acid ABC transporter (permease protein); and SMu0219,a predicted amino acid ABC transporter, permease (potential glutamine permease).","Mon Apr 15 15:50:59 2002","","No significant hits to the NCBI PDB database.","SMU.2119","","Residues 22 to 215 (E-value = 5.7e-29) place SMu1923 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component (PF00528)","Wed Jan 2 11:49:53 2002","24380451","","","Kappes,R.M., Kempf,B., Kneip,S., Boch,J., Gade,J., Meier-Wagner,J. and Bremer,E. Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis. Mol. Microbiol. 32 (1), 203-216 (1999) PubMed: 10216873.","","Wed Jan 2 11:55:25 2002","1","Wed Jan 2 11:55:25 2002","","SMU.2119","" "SMu1924","1988400","1987822","579","ATGCTATCAAAAAAATTTAAACAAGTTATGGAAACAGATACCATTGCAACAGCCAAGGCTTTATTAGGAATGCAATTGTGTCTGGATGATAAGCCCTTAGGGAGAATTGTTGAAACAGAAGCTTATTTAGGGAGCAAAGACAGTGCTTGTCATAGCGCAAATGATCGCAGAACTCCTAAAAATGAAGCCATGTATTTAGCGGCGGGGCATTGGTATGTTTATCAAATTTATGGACATCAAATGTTGAATTTAGTGACTAAGCCTCAAAATGTAGCTGAAGCCGTTTTGATTCGAGCACTTGAAACAGCTGACGGTCATTTATTAGCCAATGGACCTGGTAAACTGACAAAATTTGCGGGCATTGATAAAAGCTTTAATGGTGATTCTTTACAAGACTCTAGGCTGAGTTTACAAGAGGATTTATCACCCCAGCGTATTGAAGAACGTTCTCGCATTGGTGTGACTTGTACTGATGAGTGGAAAGATGCGCTGCTTTGTTTTTATGTTAGGGGAAATCAACATGTTTCAAAGATAGCTAAAAAAAGCCTCTTAACGGACAAAGAGACTTGGAAATCTTAA","8.20","3.01","21460","MLSKKFKQVMETDTIATAKALLGMQLCLDDKPLGRIVETEAYLGSKDSACHSANDRRTPKNEAMYLAAGHWYVYQIYGHQMLNLVTKPQNVAEAVLIRALETADGHLLANGPGKLTKFAGIDKSFNGDSLQDSRLSLQEDLSPQRIEERSRIGVTCTDEWKDALLCFYVRGNQHVSKIAKKSLLTDKETWKS","1987840","","probable 3-methyladenine DNA glycosylase","Cytoplasm, Periplasm, Extracellular","Many moderate matches in gapped BLAST to 3-methyladenine DNA glycosylases; e.g. residues 34-177 are 39% similar to this protein of B.subtilis (gi|3912954); residues 1-191 are 36% similar to this protein of Listeria monocytogenes (gi|16802968).SMu1924 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR003180
Family

Methylpurine-DNA glycosylase (MPG)
PD009649	$\"[13-170]T$	PurDNA_glycsylse
G3DSA:3.10.300.10	$\"[7-188]T$	PurDNA_glycsylse
PTHR10429	$\"[28-180]T$	PurDNA_glycsylse
PF02245	$\"[11-174]T$	Pur_DNA_glyco
TIGR00567	$\"[1-176]T$	3mg

InterPro
IPR011034
Domain

Formyl transferase, C-terminal-like
SSF50486	$\"[1-185]T$	FMT_C_like

","BeTs to 5 clades of COG2094COG name: 3-methyladenine DNA glycosylaseFunctional Class: LThe phylogenetic pattern of COG2094 is ---------br-----o--nxNumber of proteins in this genome belonging to this COG is 1","***** IPB003180 (Methylpurine-DNA glycosylase (MPG)) with a combined E-value of 2.5e-26. IPB003180A 5-29 IPB003180B 40-85 IPB003180C 89-113 IPB003180E 164-176","Residues 34-176 are 29% similar to a (GLYCOSIDASE DNA 3-METHYLADENINE 3.2.2.-) protein domain (PD103774) which is seen in Q9RSQ0_DEIRA.Residues 34-177 are 39% similar to a (DNA GLYCOSYLASE 3-METHYLADENINE) protein domain (PD009649) which is seen in 3MGH_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 14:42:05 2002","Wed Jan 2 11:36:48 2002","Wed Jan 2 11:42:08 2002","Thu Oct 10 14:42:05 2002","Wed Jan 2 11:36:48 2002","Wed Jan 2 11:36:48 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1924 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 11:39:14 2002","Wed Jan 2 11:36:48 2002","pdb|1BNK|A Chain A, Human 3-Methyladenine Dna Glycosylase Compl... 89 4e-019pdb|1F4R|A Chain A, Crystal Structure Of The Human Aag Dna Repa... 89 5e-019pdb|1EWN|A Chain A, Crystal Structure Of The Human Aag Dna Repa... 87 1e-018","SMU.2120c","","Residues 11 to 174 (E-value = 2.7e-44) place SMu1924 in the Pur_DNA_glyco family which is described as Methylpurine-DNA glycosylase (MPG) (PF02245)","Wed Jan 2 11:36:48 2002","24380452","","","","","","1","","","SMU.2120c","" "SMu1925","1988713","1988426","288","ATGTTTATCATCAATCTTACCTATCAAAAGAATCTAACAGAAGTTGAAAAACACCTTGAAGCTCATATTCAATTTTTGGATACATATTATGCTTCTGGTTATTTCATCGCTTCGGGCAGAAAAAATCCTCGAACAGGTGGTATCATCTTAGCAAAAGCTGCTGATTTGGCAGAAATTGAGAGAATTATTAGTGAAGATCCTTTTAAGATCAATGAGATTGCAAACTATGATATCATAGAATTTTGTCCGACGAAATCGTCAAAAGCTTTTGAAAAAGTCTTAAAGTAA","6.50","-0.58","10841","MFIINLTYQKNLTEVEKHLEAHIQFLDTYYASGYFIASGRKNPRTGGIILAKAADLAEIERIISEDPFKINEIANYDIIEFCPTKSSKAFEKVLK","1988444","","conserved hypothetical protein","Cytoplasm","Few matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-94 are 51% similar to uncharacterized conserved protein, YCII family of Clostridium acetobutylicum (gi|15004742); residues 1-91 are 47% similar to conserved hypothetical protein of Yersinia pestis (gi|16121990).SMu1925 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR005545
Domain

YCII-related
PF03795	$\"[7-85]T$	YCII

InterPro
IPR011008
Domain

Dimeric alpha-beta barrel
SSF54909	$\"[1-85]T$	Dimer_A_B_barrel

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-91 are 43% similar to a (PROTEOME COMPLETE) protein domain (PD353147) which is seen in Q9X7N1_STRCO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:53:43 2002","Wed Jan 2 11:34:42 2002","Wed Jan 2 11:34:42 2002","Wed Jan 2 11:34:42 2002","","Wed Jan 2 11:34:42 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1925 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:53:43 2002","","No significant hits to the NCBI PDB database.","SMU.2121c","","Residues 7 to 85 (E-value = 2.4e-19) place SMu1925 in the YCII family which is described as YCII-related domain (PF03795)","Wed Jan 2 11:34:42 2002","24380453","","","","","","1","","","SMU.2121c","" "SMu1926","1988917","1989540","624","ATGAAAAATCAGATCTTTAAACAAAATAGAGATGATTGTCTAGTCTCATGGGCGTTTCTTGCTGGTATTTTGTTATATATGGTGATTCGGTTTGGCTTTTTATATTTCAGCTTACAACTAAAGTTGACAAACTCCTTACACCAAACCATAAATCAACATAGAAGTTTACTGATGACCATGGACGAATTACTCATGCTCTCAACTATCCTTTTTGGATGCACTTTTTATAGTATACGCAAACGATATTTTCAAAATAAAAAAATACTAACAGGACTTCTAATGACAAATTTTACACTATTATTAATATCATGGCTATTAATAGTAGTAGAAACTGGCAGACTTATCTATCCTATCAATGGTTTATCTGCCGTCATAGGTGACAACCTTCAGACAACTTTAGCCGAAATTTATGCAACTTGGCATTTATGTGACATCTTACTAGGACTATTCATAATTTCATGGTCCGGATTATTACCCCATCCTTTTTGGAAATACAGCGGAGTAATTATTGGACTGATGCAAATACTCTGTACTTATTTTGGACAAGGTATAAAGCCAATACCCTTGTCAATGGCAATCATCTTATCAACGATCTGGTTGTTAAAAAGATGGCAACATTTTTAA","10.20","8.99","24002","MKNQIFKQNRDDCLVSWAFLAGILLYMVIRFGFLYFSLQLKLTNSLHQTINQHRSLLMTMDELLMLSTILFGCTFYSIRKRYFQNKKILTGLLMTNFTLLLISWLLIVVETGRLIYPINGLSAVIGDNLQTTLAEIYATWHLCDILLGLFIISWSGLLPHPFWKYSGVIIGLMQILCTYFGQGIKPIPLSMAIILSTIWLLKRWQHF","1989552","","hypothetical protein","Membrane, Cytoplasm","No matches in gapped BLAST.SMu1926 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-34]?$	signal-peptide
tmhmm	$\"[15-37]?$ $\"[56-78]?$ $\"[88-108]?$ $\"[137-157]?$ $\"[162-180]?$ $\"[186-204]?$	transmembrane_regions

InterPro
IPR002577
Domain

Helix-turn-helix, HxlR type
PF01638	$\"[7-94]T$	DUF24
PS51118	$\"[1-94]T$	HTH_HXLR

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-90]T$	SSF46785

","BeTs to 7 clades of COG1733COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1733 is Amt----ceBR----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 7-94 are 36% similar to a (PROTEOME COMPLETE YVAP CSPC-NAP) protein domain (PD004032) which is seen in YCKH_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:50:35 2002","Wed Jan 2 11:28:07 2002","Wed Jan 2 11:28:07 2002","Mon Apr 15 15:52:14 2002","","Wed Jan 2 11:28:07 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1928 is paralogously related (blast p-value < 1e-3) to SMu0311, a predicted conserved hypothetical protein / possible transcriptional regulator.","Mon Apr 15 15:52:14 2002","","No significant hits to the NCBI PDB database.","SMU.2125","","Residues 7 to 94 (E-value = 8.5e-13) place SMu1928 in the DUF24 family which is described as Transcriptional regulator (PF01638)","Wed Jan 2 11:28:07 2002","24380456","","","","","","1","","","SMU.2125","" "SMu1929","1990697","1989936","762","ATGATTTTAAGTAACTTTGATGATGCAAAAAAAGCGATTATTAATCCAGAAGATTTAGTCGCAGCCATTCCGGATTTCCCTGAAATAGTAGTATCTTGCTTTGCTAGAGCAACCTTCAAACACATGTTAAAACGTTATAAATATCGCTTATTGACAAAAACTTCTGTGGCTAATCTTGATATTCCTATTTATGAACTTGATTATCATGGTCGTAAGTTGGCCGTTTTTAATGCTTATGTTGGTGCTGCTGGCTGTGTTGCCGTTTTGGAAGACCTAGTTGCCATGGGAATGAAGAAGCTGATTCTTTTTGGAACATGTGGTATTTTGGAGGAACAGGTTAAGGAAACGTCTATTATTGTTCCGACAATTGCTGTACGCGATGAAGGAACCAGTTTTCATTATTCCCCAGCACAAAATGAAATCTCAGTTAATGACAGAACTTTAGCAAAATTTTTGACCTATTTACAAGCTGAAAATATCTCTTTTTCAAAAGGGAAAGTTTGGACAACTGATGGCATTTATCGTGAAACGATTACTAAGATGAAAGCTCGTAAACAAGAAGGTTGTCTAGCGGTTGATATGGAATGTTCGGCAGTCGCTGCTTGGGGACAATTTAGAGAAATTGCTGTCTGTCAGTTCTTTTATGCTGCAGATCATCTATCAGAAGAAAGATGGCATCCGAGGTCTTTAGGCAATGAAGCCGATTTAGATGAGAAAGATAAAATTGCTGAAATTGCTTTAAATTTTTCAACTTATCTTTGA","5.80","-4.07","28426","MILSNFDDAKKAIINPEDLVAAIPDFPEIVVSCFARATFKHMLKRYKYRLLTKTSVANLDIPIYELDYHGRKLAVFNAYVGAAGCVAVLEDLVAMGMKKLILFGTCGILEEQVKETSIIVPTIAVRDEGTSFHYSPAQNEISVNDRTLAKFLTYLQAENISFSKGKVWTTDGIYRETITKMKARKQEGCLAVDMECSAVAAWGQFREIAVCQFFYAADHLSEERWHPRSLGNEADLDEKDKIAEIALNFSTYL","1989954","","possible phosphorylase","Cytoplasm","Few matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 6-234 are 31% similar to conserved hypothetical protein of S.pneumoniae (gi15902112). Also one hit to phosphorylase, Pnp/Udp family; residues 62-234 are 35% similar to phosphorylase of Streptococcus pneumoniae (gi15900020).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0414 (2e-49).","

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.1580	$\"[25-253]T$	G3DSA:3.40.50.1580
PTHR21234	$\"[67-198]T$	PTHR21234
PTHR21234:SF7	$\"[67-198]T$	PTHR21234:SF7
SSF53167	$\"[14-253]T$	SSF53167

","BeTs to 4 clades of COG0813COG name: Purine-nucleoside (and uridine) phosphorylaseFunctional Class: FThe phylogenetic pattern of COG0813 is --------Eb-HUJgp-L---Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:49:35 2002","Thu Jul 6 16:47:36 2006","Thu Jul 6 16:47:36 2006","Mon Apr 15 15:53:19 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1929 is paralogously related (blast p-value < 1e-3) to SMu1122, a predicted purine-nucleotide phosphorylase.","Mon Apr 15 15:53:19 2002","","No significant hits to the NCBI PDB database.","SMU.2126c","","Residues 35 to 247 (E-value = 4.3e-05) place SMu1929 in the PNP_UDP_1 family which is described as Phosphorylase family (PF01048)","Wed Jan 2 11:20:50 2002","24380457","","","","","","1","","","SMU.2126c","771" "SMu1930","1990883","1992259","1377","ATGGCCTATAAGACAACTTATCCCTATACTAATGAAGTTTTGAAGGAATTTGCTAATAATAGCGATGCCGATTTAGAAAAAGCATTGGTTACTGGACATGCGCTTTATAAAAAATGGCGTGCTGAAGGAGGCTTAGAGGAGCGTAAAGCTCAATTGCATAAAGTTGCGGATATCCTTCGTCGCGATGTGGATAAATACGCCGAAGTCATGACCAAGGACATGGGAAAACTCTTTACAGAAGCTAAAGGTGAGGTTGAACTGTGTGCAGAAATCGCTGACTATTTTGCTGATAAGGCTGAAGAATTTTTAGAACCAAAAGCATTTGAACCTATTCATGGTGATGCCTATTACATTAAGCAAGCAGTTGGTGTGCTCTTTATGGTCGAACCATGGAACTTCCCATTCTATCAAATTATGCGTGTTTTTGCTCCTAATTTTATGATTGGCAACCCAACGGTTTTGAAACACGCATCTATCTGTCCTGCTTCTGCTCAGGCTTTTGAGAATTTGGTTAAAGAAGCAGGCGCTCCTGAAGGGTCATTTAAGAATCTTTTCCTTACTTATGATCAAGTTAACAAGGCTATTGCTGATCCTCGTATTCAAGGGGTGGCCTTAACCGGTTCTGAACGTGGTGGTGCTTCTATTGCTGCTGAAGCGGGAGCAAATCTTAAGAAATCTGCTCTTGAACTCGGCGGTAATGATGCTTTTCTCATTTTGGAAGATGCTGACTTTGAACTCTTAAAAGATACTATTTTCTTTGCACGCCTTTACAATGCAGGTCAAGTCTGTACATCATCCAAACGTTTCATTGTTGTTGGTGAAGAAAACTACAAGAAATTTCTTGATATGGTTGTTGAAACCTTCAAAACAGCCAAGTGGGGTGACCCGATGGATCCTGAAACAACGCTTGCGCCCTTGTCATCAGCCGAAGCTAAGGAAGAAGTTCTTGGTCAAATCAAGTTAGCTGCTGACAACGGAGCACGTGTGGTTTACGGTAATAAACCAATTGACCATCCAGGAAACTTTGTCTTTCCAACCGTTTTGACCGATATTACCAAGGAAAATCCAATCTACAATCAAGAAATTTTTGGTCCAGTAGCTTCCATTTACAAAGTTGATACAGAAGAAGAAGCTATTGCCTTAGCCAATGATTCTAGTTACGGACTTGGTGGTACAGTTTTCTCTAAAGACCTTGAACACGCAAAAGCTGTTGCTGCTAAAATCGAAACAGGAATGACCTTTATCAATTCCGGTTGGTCTTCCTATCCAGAAGTTCCATTTGGCGGTATTAAAAATTCAGGTTATGGTCGTGAGCTCAGCAATCTCGGATTTGATGCCTTTGTCAATGAACATTTAGTTTTCATTCCCAAACAATAA","4.80","-17.40","50448","MAYKTTYPYTNEVLKEFANNSDADLEKALVTGHALYKKWRAEGGLEERKAQLHKVADILRRDVDKYAEVMTKDMGKLFTEAKGEVELCAEIADYFADKAEEFLEPKAFEPIHGDAYYIKQAVGVLFMVEPWNFPFYQIMRVFAPNFMIGNPTVLKHASICPASAQAFENLVKEAGAPEGSFKNLFLTYDQVNKAIADPRIQGVALTGSERGGASIAAEAGANLKKSALELGGNDAFLILEDADFELLKDTIFFARLYNAGQVCTSSKRFIVVGEENYKKFLDMVVETFKTAKWGDPMDPETTLAPLSSAEAKEEVLGQIKLAADNGARVVYGNKPIDHPGNFVFPTVLTDITKENPIYNQEIFGPVASIYKVDTEEEAIALANDSSYGLGGTVFSKDLEHAKAVAAKIETGMTFINSGWSSYPEVPFGGIKNSGYGRELSNLGFDAFVNEHLVFIPKQ","1992271","From GenBank (gi:6685461): In D.radiodurans, this protein catalyzes the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NADPH. This is involved in the 4-aminobutyrate (GABA) degradation pathway. This protein belongs to the aldehyde dehydrogenases family.","succinic semialdehyde dehydrogenase (NAD-dependent aldehyde dehydrogenase)","Cytoplasm","Numerous strong matches in gapped BLAST to succinic semialdehyde dehydrogenases/NAD-dependent aldehyde dehydrogenases; e.g. residues 1-458 are 70% similar to succinic semialdehyde dehydrogenase of Streptococcus pyogenes (gi|15675059); residues 1-455 are 50% similar to NAD-dependent aldehyde dehydrogenase of Salmonella typhimurium (gi|16767763).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1124 (0.0).","

InterPro
IPR002086
Domain

Aldehyde dehydrogenase
PF00171	$\"[3-453]T$	Aldedh
PS00687	$\"[228-235]?$	ALDEHYDE_DEHYDR_GLU

InterPro
IPR012303
Family

NAD-dependent aldehyde dehydrogenase
PIRSF000147	$\"[2-458]T$	DHA

InterPro
IPR015590
Domain

Aldehyde Dehydrogenase_
PTHR11699	$\"[31-456]T$	Aldehyde_dehyd

noIPR
unintegrated

unintegrated
G3DSA:3.40.605.10	$\"[3-271]T$	G3DSA:3.40.605.10
PTHR11699:SF28	$\"[31-456]T$	PTHR11699:SF28
SSF53720	$\"[1-456]T$	SSF53720

","BeTs to 9 clades of COG1012COG name: NAD-dependent aldehyde dehydrogenasesFunctional Class: CThe phylogenetic pattern of COG1012 is -mt-Yq-CEBR-uj-------Number of proteins in this genome belonging to this COG is 3","***** IPB002086 (Aldehyde dehydrogenase family) with a combined E-value of 1.9e-57. IPB002086A 121-134 IPB002086C 200-220 IPB002086D 234-277 IPB002086E 342-395 IPB002086F 416-440","Residues 376-438 are 41% similar to a (DEHYDROGENASE PROTEOME COMPLETE OXIDOREDUCTASE PROLINE) protein domain (PD000187) which is seen in P94428_BACSU.Residues 305-366 are 46% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD374950) which is seen in Q9Z672_ZYMMO.Residues 296-397 are 32% similar to a (DEHYDROGENASE) protein domain (PD169647) which is seen in O87842_STRCO.Residues 372-453 are 56% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE NAD PROTEOME) protein domain (PD284668) which is seen in GABD_DEIRA.Residues 300-366 are 45% similar to a (DEHYDROGENASE PROTEOME ALDEHYDE COMPLETE) protein domain (PD384597) which is seen in O49218_ORYSA.Residues 128-179 are 51% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE NAD PROTEOME) protein domain (PD334899) which is seen in GABD_DEIRA.Residues 373-434 are 49% similar to a (DEHYDROGENASE NAD OXIDOREDUCTASE ALDEHYDE) protein domain (PD389567) which is seen in Q9X8J9_STRCO.Residues 195-298 are 47% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE PROTEOME COMPLETE) protein domain (PD000218) which is seen in Q9Z672_ZYMMO.Residues 305-364 are 43% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE NAD COMPLETE) protein domain (PD407786) which is seen in P96417_MYCTU.Residues 295-458 are 25% similar to a (NAD DEHYDROGENASE OXIDOREDUCTASE ALDEHYDE) protein domain (PD398903) which is seen in DHAL_PSESP.Residues 305-369 are 49% similar to a (DEHYDROGENASE ALDEHYDE OXIDOREDUCTASE) protein domain (PD391678) which is seen in GABD_DEIRA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 15:54:41 2002","Wed Jan 2 10:54:36 2002","Mon Oct 21 09:45:07 2002","Mon Apr 15 15:54:41 2002","Wed Jan 2 10:54:36 2002","Wed Jan 2 10:54:36 2002","yes","Tue Oct 29 08:21:10 2002","SMu1930 is paralogously related (blast p-value < 1e-3) to SMu0618 ,a predicted NADP-dependent glyceraldehyde-3-phosphate dehydrogenase and SMu0131, a predicted alcohol-acetaldehyde dehydrogenase.","Mon Apr 15 15:54:41 2002","Wed Jan 2 10:54:36 2002","pdb|1CW3|A Chain A, Human Mitochondrial Aldehyde Dehydrogenase ... 213 3e-056pdb|1AG8|A Chain A, Aldehyde Dehydrogenase From Bovine Mitochon... 212 8e-056pdb|1BPW|B Chain B, Betaine Aldehyde Dehydrogenase From Cod Liv... 210 3e-055","SMU.2127","","Residues 2 to 457 (E-value = 1.5e-99) place SMu1930 in the Aldedh family which is described as Aldehyde dehydrogenase family (PF00171)","Wed Jan 2 10:54:36 2002","24380458","","","","Tue Oct 29 08:21:10 2002","","1","","","SMU.2127","" "SMu1931","1992471","1994186","1716","ATGACTGACAAAAAAACTCTTAAAGACTTAAGAAATCGTAGTTCTGTTTACGATTCAATGGTTAAATCACCTAATCGTGCTATGTTGCGTGCAACTGGTATGCAAGATGAAGACTTTGAAAAACCTATCGTCGGTGTCATTTCAACTTGGGCTGAAAACACACCTTGTAATATCCACTTACATGACTTTGGTAAACTAGCCAAAGTCGGTGTTAAGGAAGCTGGTGCTTGGCCAGTTCAGTTCGGAACAATCACGGTTTCTGATGGAATCGCCATGGGAACCCAAGGAATGCGTTTCTCCTTGACATCTCGTGATATTATTGCAGATTCTATTGAAGCAGCCATGGGAGGTCATAATGCGGATGCTTTTGTAGCCATTGGCGGTTGTGATAAAAACATGCCCGGTTCTGTTATCGCTATGGCTAACATGGATATCCCAGCCATTTTTGCTTACGGCGGAACAATTGCACCTGGTAATTTAGACGGCAAAGATATCGATTTAGTCTCTGTCTTTGAAGGTGTCGGCCATTGGAACCACGGCGATATGACCAAAGAAGAAGTTAAAGCTTTGGAATGTAATGCTTGTCCCGGTCCTGGAGGCTGCGGTGGTATGTATACTGCTAACACAATGGCGACAGCTATTGAAGTTTTGGGACTTAGCCTTCCGGGTTCATCTTCTCACCCGGCTGAATCCGCAGAAAAGAAAGCAGATATTGAAGAAGCTGGTCGCGCTGTTGTCAAAATGCTCGAAATGGGCTTAAAACCTTCTGACATTTTAACGCGTGAAGCTTTTGAAGATGCTATTACTGTAACTATGGCTCTGGGAGGTTCAACCAACTCAACCCTTCACCTCTTAGCTATTGCCCATGCTGCTAATGTGGAATTGACACTTGATGATTTCAATACTTTCCAAGAAAAAGTTCCTCATTTGGCTGATTTGAAACCTTCTGGTCAATATGTATTCCAAGACCTTTACAAGGTCGGAGGGGTACCAGCAGTTATGAAATATCTCCTTAAAAATGGCTTCCTTCATGGTGACCGTATCACTTGTACTGGCAAAACAGTCGCTGAAAATTTGAAGGCTTTTGATGATTTAACACCTGGTCAAAAGGTTATTATGCCGCTTGAAAATCCTAAACGTGAAGATGGTCCGCTCATTATTCTCCATGGTAACTTGGCTCCAGACGGTGCCGTTGCCAAAGTTTCTGGTGTAAAAGTGCGTCGTCATGTCGGTCCTGCTAAGGTCTTTAATTCTGAAGAAGAAGCCATTGAAGCTGTCTTGAATGATGATATTGTTGATGGTGATGTTGTTGTCGTACGTTTTGTAGGACCAAAGGGCGGTCCTGGTATGCCTGAAATGCTTTCCCTTTCATCAATGATTGTTGGTAAAGGGCAAGGTGAAAAAGTTGCCCTTCTGACAGATGGCCGCTTCTCAGGTGGTACTTATGGTCTTGTCGTGGGTCATATCGCTCCTGAAGCACAAGATGGCGGTCCAATCGCCTACCTGCAAACAGGAGACATAGTCACTATTGACCAAGACACTAAGGAATTACACTTTGATATCTCCGATGAAGAGTTAAAACATCGTCAAGAGACCATTGAATTGCCACCGCTCTATTCACGCGGTATCCTTGGTAAATATGCTCACATCGTTTCGTCTGCTTCTAGGGGAGCCGTAACAGACTTTTGGAAGCCTGAAGAAACTGGCAAAAAATGA","5.10","-18.38","60772","MTDKKTLKDLRNRSSVYDSMVKSPNRAMLRATGMQDEDFEKPIVGVISTWAENTPCNIHLHDFGKLAKVGVKEAGAWPVQFGTITVSDGIAMGTQGMRFSLTSRDIIADSIEAAMGGHNADAFVAIGGCDKNMPGSVIAMANMDIPAIFAYGGTIAPGNLDGKDIDLVSVFEGVGHWNHGDMTKEEVKALECNACPGPGGCGGMYTANTMATAIEVLGLSLPGSSSHPAESAEKKADIEEAGRAVVKMLEMGLKPSDILTREAFEDAITVTMALGGSTNSTLHLLAIAHAANVELTLDDFNTFQEKVPHLADLKPSGQYVFQDLYKVGGVPAVMKYLLKNGFLHGDRITCTGKTVAENLKAFDDLTPGQKVIMPLENPKREDGPLIILHGNLAPDGAVAKVSGVKVRRHVGPAKVFNSEEEAIEAVLNDDIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGEKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLQTGDIVTIDQDTKELHFDISDEELKHRQETIELPPLYSRGILGKYAHIVSSASRGAVTDFWKPEETGKK","1994198","For other 'ilv' genes see SMu0209 (ilvB); SMu0210 (ilvH); SMu0211 (ilvC); SMu0212 (ilvA) and SMu1099 (ilvE).From GenBank (gi:1708465): In B.subtilis, this protein catalyzes the reaction: 2,3-dihydroxy-3-methylbtuanoate = 3-methyl-2-oxobutanoate + H2O. This protein binds a 4Fe-4S cluster and is involved in the fourth step in valine and isoleucine biosynthesis. It belongs to the IlvD/Edd family of proteins.","dihydroxy-acid dehydratase","Cytoplasm","Numerous matches in gapped BLAST to dihydroxy-acid dehydratases; e.g. residues 9-571 are 81% similar to dihydroxy-acid dehydratase of Streptococcus pneumoniae (gi15901940); residues 22-559 are 40% similar to dihydroxy-acid dehydratase of Bacillus subtilis (gi16079246).SMu1931 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR000581
Family

Dihydroxy-acid and 6-phosphogluconate dehydratase
PD002691	$\"[395-530]T$	ILVD_EDD_family
PTHR21000	$\"[1-563]T$	ILVD_EDD_family
PF00920	$\"[41-561]T$	ILVD_EDD
PS00886	$\"[129-139]T$	ILVD_EDD_1
PS00887	$\"[470-481]T$	ILVD_EDD_2

InterPro
IPR004404
Family

Dihydroxy-acid dehydratase
TIGR00110	$\"[24-562]T$	ilvD

InterPro
IPR009000
Domain

Translation elongation and initiation factors/Ribosomal, beta-barrel
SSF50447	$\"[49-146]T$	Translat_factor

","BeTs to 11 clades of COG0129COG name: Dihydroxyacid dehydratase/phosphogluconate dehydrataseFunctional Class: E,GThe phylogenetic pattern of COG0129 is amt-yqvcEbrhuj-------Number of proteins in this genome belonging to this COG is 1","***** IPB000581 (Dihydroxy-acid and 6-phosphogluconate dehydratase) with a combined E-value of 1.8e-105. IPB000581A 81-112 IPB000581B 191-225 IPB000581C 255-293 IPB000581D 315-337 IPB000581E 383-393 IPB000581F 469-497","Residues 16-70 are 50% similar to a (DEHYDRATASE DIHYDROXY-ACID LYASE) protein domain (PD357182) which is seen in ILVD_MYCTU.Residues 71-521 are 50% similar to a (DEHYDRATASE DIHYDROXY-ACID LYASE) protein domain (PD002691) which is seen in ILVD_SYNY3.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Mar 1 14:34:03 2007","Wed Jan 2 10:43:20 2002","Thu Mar 1 14:34:03 2007","Mon Apr 1 13:40:11 2002","Wed Jan 2 10:43:20 2002","Wed Jan 2 10:43:20 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1931 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Jan 2 10:50:18 2002","","No significant hits to the NCBI PDB database.","SMU.2128","","No significant hits to the Pfam 11.0 database","Wed Jan 2 10:43:20 2002","24380459","","","Godon,J.J., Chopin,M.C. and Ehrlich,S.D. Branched-chain amino acid biosynthesis genes in Lactococcus lactis subsp. lactis. J. Bacteriol. 174 (20), 6580-6589 (1992) PubMed: 1400210.","","Thu Mar 1 14:34:03 2007","1","","","SMU.2128","" "SMu1932","1994680","1994339","342","ATGCGAGATGATATTAAAATAAATGACCGAGCTGCAGCGATTGGCGACCAACTGATTGAAAAACTTGAAAAAATTTATGATCCAGAGATTGAATTGGATATTTACAATCTTGGTTTGATTTATGAAATTGATTTAGATGAAGAAGGCTTCTGCAAGTTAGTTATTACATTTACTGAAGTCAATTGCGGTTGTGTTGATACTCTGCCTGCGGAAATTATTGATTCCCTGTCAGAGATAGAAGGGATCAATAAGGTTGGTGTTGAGGTTGTTTGGTCACCAGCTTGGAAGATGACACGGATTAGTCGATTTGGTAGAATAGCATTGGGAATCAGCCCTAAATAA","4.20","-10.14","12700","MRDDIKINDRAAAIGDQLIEKLEKIYDPEIELDIYNLGLIYEIDLDEEGFCKLVITFTEVNCGCVDTLPAEIIDSLSEIEGINKVGVEVVWSPAWKMTRISRFGRIALGISPK","1994357","","conserved hypothetical protein","Cytoplasm","Several moderate matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-113 are 66% similar to conserved hypothetical protein of Streptococcus pneumoniae (gi|15901939); residues 14-110 are 42% similar to conserved hypothetical protein of Lactococcus lactis (gi|15672865).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1425 (6e-20).","

InterPro
IPR002744
Domain

Protein of unknown function DUF59
PD005595	$\"[19-96]T$	DUF59
PF01883	$\"[14-89]T$	DUF59

","BeTs to 6 clades of COG2151COG name: Putative aromatic ring hydroxylating enzymeFunctional Class: RThe phylogenetic pattern of COG2151 is -mtk--v-ebr----------Number of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 16-89 are 36% similar to a (COMPLETE PROTEOME ATP-BINDING HOMOLOG) protein domain (PD005595) which is seen in Q9CH56_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:48:34 2002","Wed Jan 2 10:38:13 2002","Wed Jan 2 10:38:13 2002","Mon Apr 15 15:55:41 2002","","Wed Jan 2 10:38:13 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1932 is paralogously related (blast p-value < 1e-3) to SMu0747, a predicted conserved hypothetical protein.","Mon Apr 15 15:55:41 2002","","No significant hits to the NCBI PDB database.","SMU.2129c","","Residues 14 to 89 (E-value = 1.6e-14) place SMu1932 in the DUF59 family which is described as Domain of unknown function DUF59 (PF01883)","Wed Jan 2 10:38:13 2002","24380460","","","","","","1","","","SMU.2129c","" "SMu1933","1994869","1995813","945","ATGAAAATTTTCAGAAACCCTCCCCTTGTTATGTCAGGACTAACTTTGGGATTGTTTGCTCTAGGTAATTTATTAAAACTATATCATCCTTCTCTACGGCATTTACTAAGTATTATAGCGCTCTTACTCTACCTGTTTTTAATACTCAGTATTTTAAAAAATTTATCTCAAGCTTTAGAACAAATAAAGCATCCTTTAATCGCTTCTATTTTTCCAACCTTTTTTATGTCAGGTATGCTGTTGGCAGGCTATATCCAAACTTTTCCTTTTTTAGAAGATTGGGTTACTCTTATTAGCCTGACGATTTGGTGGCTCGCTTTTCTAGGCAACGCAGGACTGATTGCTTATTTTACAATTAAGTTCGTCATCCCTTTTCATTGGGAACATGTTTTTCCATCTTGGTCAGTTTTATACGTTGGAATTGCAGTAGCAACCTTAACAGCACCCATCAGTGGACAATATATTTTGGGTCAAATCATCTTTTGGACTTGTCTCCTTTTAACTTTGCTGATTTTACCTTTGATGACTATTAAAGCCTATTGTATTGGTTTACCTGAGACAGCAAAACCGAATATTTGCACATTTTGTGCTCCTTTGTCTCTTTTATTGGCTGGCTATTTAAAGACATTTCCTCCCGAACAAAGCCCTAATACTAATTTTGTTTGGCTTTTGCTTTTAGCCTCCCAATTACTTTACTTTTTTGTTGTGCTTCAGCTTCCTGTACTTCTCAAAAGAGAGTTTAATCCTGGCTTTTCAGCTTTTACCTTTCCCTTTGCTATCTCTGCTACTGCCCTTCGTTCAGCAGGTTCTTATCTGCATTTACAACTGCCTCTATTTCAGTTATTAGTTAAACTAGAGGAATTACTGGCTAGCATATTAGTCTTATTCATTTTATACTCTTATCTTCGATTTTTAAGTAAACAAGAAGACCTTCCTTCAAATTAA","9.30","6.24","35452","MKIFRNPPLVMSGLTLGLFALGNLLKLYHPSLRHLLSIIALLLYLFLILSILKNLSQALEQIKHPLIASIFPTFFMSGMLLAGYIQTFPFLEDWVTLISLTIWWLAFLGNAGLIAYFTIKFVIPFHWEHVFPSWSVLYVGIAVATLTAPISGQYILGQIIFWTCLLLTLLILPLMTIKAYCIGLPETAKPNICTFCAPLSLLLAGYLKTFPPEQSPNTNFVWLLLLASQLLYFFVVLQLPVLLKREFNPGFSAFTFPFAISATALRSAGSYLHLQLPLFQLLVKLEELLASILVLFILYSYLRFLSKQEDLPSN","1995825","","exfoliative toxin A","Membrane, Cytoplasm","Few matches in gapped BLAST to exfoliative toxins; e.g. residues 1-305 are 39% similar to putative exfoliative toxin of Streptococcus pyogenes (gi15674939); residues 61-268 are 37% similar to exfoliative toxin A of Staphylococcus hyicus (gi9757655).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1215 (3e-49).","

InterPro
IPR004695
Family

C4-dicarboxylate transporter/malic acid transport protein
PF03595	$\"[9-264]T$	C4dic_mal_tran

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 61-211 are 35% similar to a (A TOXIN EXFOLIATIVE) protein domain (PD399902) which is seen in Q9FDT4_STAHY.Residues 232-268 are 62% similar to a (A PROTEOME COMPLETE TOXIN) protein domain (PD317589) which is seen in Q9FDT4_STAHY.Residues 59-207 are 26% similar to a (COMPLETE PROTEOME RESISTANCE) protein domain (PD011389) which is seen in Q9CII2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 23 09:55:36 2002","Thu Sep 14 10:26:59 2006","Thu Sep 14 10:26:59 2006","Wed Jan 2 10:34:24 2002","","Wed Jan 2 10:34:24 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1933 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 10 14:26:50 2002","","No significant hits to the NCBI PDB database.","SMU.2130","","No significant hits to the Pfam 11.0 database","Wed Jan 2 10:34:24 2002","24380461","","","Watanabe,T., Sato,H., Hatakeyama,Y., Matsuzawa,T., Kawai,M., Aizawa,C., Danbara,H. and Maehara,N. Cloning of the gene coding for Staphylococcus hyicus exfoliative toxin B and its expression in Escherichia coli. J. Bacteriol. 182 (14), 4101-4103 (2000) PubMed: 10869091..","","Thu Sep 14 10:26:59 2006","1","","","SMU.2130","936" "SMu1934","1995815","1995979","165","ATGACATTTCATTTAAAATCTGAAAAATCTCCCAAACTCAAACCAAACATAAACTTTTTTGTGATTTTTTTCTTAGTGTTAAAAACTTTAGTTCGAAACGAAAGAAAAAGTCCTATCATCTCTGCAGTAGATATTGCCTACTATGGAGATGAAGGACTCCAATAA","10.40","3.22","6240","MTFHLKSEKSPKLKPNINFFVIFFLVLKTLVRNERKSPIISAVDIAYYGDEGLQ","1995991","","hypothetical protein","Cytoplasm, Extracellular","No significant hits in gapped BLAST found.SMu1934 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

noIPR
unintegrated

unintegrated
signalp	$\"[1-33]?$	signal-peptide

","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:44:56 2002","Wed Jan 2 10:26:50 2002","Tue Oct 8 13:44:56 2002","Wed Jan 2 10:26:50 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1934 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:44:19 2002","","No significant hits to the NCBI PDB database.","SMU.2131","","No significant hits to the Pfam 11.0 database","Wed Jan 2 10:26:50 2002","24380462","","","","","","1","","","SMU.2131","" "SMu1935","1998508","1996004","2505","ATGTTAACGGAATTAAAAGCGGTTTTAAAAAAGCCTATGCTTTGGATTACGATGGTAGGAGTAGCCCTTGTCCCTGCCCTATATAATATTATTTTTTTGAGTTCTATGTGGGATCCTTATGGCAAAGTATCTGATTTACCTGTTGCAGTTGTTAATAAAGATAAAACGGCAACTTATGAAGGAAAGAAGATGACTATCGGTAAAGATATGACTGATAATATGGTCCGTAATAAAAGTTTGGACTATCATTTTGTTGATAGCGAAAAAGCTCAAAAGGGACTTGAAAAAGGTGATTACTATATGATCATTACTTTACCAGAAGATCTTTCTCAAAATGCGGCTAGTGTTTTAACAGATGAACCTAAAAAGCTAACGATTCCTTACCAAACGTCTAAAGGACATAGTTTTGTTGCCTCCAAAATGAGTGAAACTGCTGCTAAGACTTTAAAAGAGTCTGTGTCGAAAAACATTACAAGTTCTTACACCAAATCACTTTTTAAGAATATGTCAACCCTAAAAACAGGTCTTGGCAGTGCGGCTAATGCAAGTCAAAAAATAGCGACTGGTTCAAAACAGTTAGCAAATGGCAGTCAAGTGATGACTGATAATCTGAATTTACTTTCAAATTCAAGTCAATCATTTGCTCAAGGGACTAATACCTTATATTCGGGCTTAACAGCTTATACGGGAGGTGTCGGTCAGCTTTCTGCAGGTTTAAATAATTTAAACAATGGTTTGACAGCTTATACAAATGGAGTTGGTCAGTTAGCAAATGGCAGCAGCCAACTGAGCAATCAATCTCAGAAGCTTCTAGGAGGTGTTGCGCAATTAGCGAATGGTTCTGCTTCTATTCAACAATTGGTTAATGCTAGCAGTCAGTTGAATCAAGGACTTATTAAGCTGTCAACAGCAACAGGTCTTTCTGAAGAACAAGTTCAACAGTTTAGCTCATTGATTAATCAGTTGGGAACTTTGAATCAAAGTATTCAAAATTACAGTGATAATGGGACAGCAACGACTGCAAATAGTCCTGATCTTAGTACGTATTTATCTGCCATTACAACAGCAGCTCAAGCAATTGTTAATTCAGGAAATACGTCTCAGCAAACAACAACTAATCAGTCCAATGCATTGGCTGCAGTCCAAGCTACAGGTGCTTATCAAAGATTATCCGCTGAGGATCAATCAGAGATCGCTGCAGCTTTGGCCAACACTGGTAGTTCAACAACAACTACAGGTGCTGATGCAAACGCAGTGTCACAAGCCCAAGCTATCCTAAACAATGTCCAAAGTATTCAAAGTGCCTTATCTACTTTACAGACAACAACTGCTAATACACCAACAAGCCCATCAGCCAGCTTGACTCAAATTAAAAATACAGCTAATTCTGTATTACCTAGTGCGGCAACTTCCTTGACAACCTTGTCAAGTGGTTTGACACAAGCAAAAACAGCTCTTGATTCGCAAGTAGTCCCTGTCAGCACAGCCCTTGCTAATGGTACGGCTCAATTAGGCTCTACTTTTTCAACAGGCGCCAATTCCTTGATGACAGGAGTAGGCCAATACACTAATGCAGTTGATATTCTTAATGCAGGAGCTAATACTTTGGCTGCTAAAAATAACCAGTTAACAGATGGTACAAGTCAATTGGTAAATGGTGCCAATCAATTAAATAGCAACTCTGGACAATTAACGAAAGGGACTGCACAGTTAGCAAATGGTGCTAATCAAATAGAGACAGGAGCTGGCAAATTGGCTGCAGGTGGAGAAAGTTTAACGGCGGGCTTGACAACTTTGTCAAGTGGTAGTGGTGAACTGTCGAAAGCATTGTCAACTGCTAAAAATAAATTATCATTAGTAGCAGTTGACAATGATAATGCTAAGACTTTGTCAAGTCCTGTCACTATCAAGCATACAGATAAAGATAATGTCAAAACAAATGGTGTTGGAATGGCTCCTTATATGATGTCAGCAGCTTTAATGGTAATGGCAATTTCAACCAATACTATCTTTAGAGTAGCACTTTCTGGTAAGCAAGCTAAAACCCTACGAGAATGGATAGATCAAAAGTTAGCAGTCAATGGCTTGATTGCTGTTACTGGAGCTATTATTCTCTATTTTGGTGTTCATATTATTGGTTTATCAGCTAATTTTGAACTAAAAACTTTAGGATTAATTATTCTTACCAGTATCACTTTTATGGTCTTAGTGACAACTTTGGTAACTTGGCATGATAAATTTGGCTCTTTTGCTGCCTTAATTTTACTTTTACTACAATTAGGTTCCAGTGCAGGAACCTATCCCTTAGCCGTTACAGATAAGTTTTTCCAAGTTGTCAATCCTTATTTACCAATGAGTTATTCGGTTTCTGGTTTACGAGAAACCATTTCTATGGCTGGTACAATTGGTAATCAACTACTAGCGCTGAGTTTATTTTTCCTTACTTTTGCTGCTTTAGGATTGTTAATCGCTCGAAGGAGGATTAGGTCTGTCAAAGTAGCCTAA","10.10","13.22","86773","MLTELKAVLKKPMLWITMVGVALVPALYNIIFLSSMWDPYGKVSDLPVAVVNKDKTATYEGKKMTIGKDMTDNMVRNKSLDYHFVDSEKAQKGLEKGDYYMIITLPEDLSQNAASVLTDEPKKLTIPYQTSKGHSFVASKMSETAAKTLKESVSKNITSSYTKSLFKNMSTLKTGLGSAANASQKIATGSKQLANGSQVMTDNLNLLSNSSQSFAQGTNTLYSGLTAYTGGVGQLSAGLNNLNNGLTAYTNGVGQLANGSSQLSNQSQKLLGGVAQLANGSASIQQLVNASSQLNQGLIKLSTATGLSEEQVQQFSSLINQLGTLNQSIQNYSDNGTATTANSPDLSTYLSAITTAAQAIVNSGNTSQQTTTNQSNALAAVQATGAYQRLSAEDQSEIAAALANTGSSTTTTGADANAVSQAQAILNNVQSIQSALSTLQTTTANTPTSPSASLTQIKNTANSVLPSAATSLTTLSSGLTQAKTALDSQVVPVSTALANGTAQLGSTFSTGANSLMTGVGQYTNAVDILNAGANTLAAKNNQLTDGTSQLVNGANQLNSNSGQLTKGTAQLANGANQIETGAGKLAAGGESLTAGLTTLSSGSGELSKALSTAKNKLSLVAVDNDNAKTLSSPVTIKHTDKDNVKTNGVGMAPYMMSAALMVMAISTNTIFRVALSGKQAKTLREWIDQKLAVNGLIAVTGAIILYFGVHIIGLSANFELKTLGLIILTSITFMVLVTTLVTWHDKFGSFAALILLLLQLGSSAGTYPLAVTDKFFQVVNPYLPMSYSVSGLRETISMAGTIGNQLLALSLFFLTFAALGLLIARRRIRSVKVA","1996022","In gapped BLAST, the central portion of this protein is not well conserved in relation to the N-terminal and C-terminal regions; e.g. residues 3-359 are 28% similar to residues 6-355 and residues 482-797 are 23% similar to residues 437-730 of B. subtilis conserved hypothetical protein (similar to a phage infection protein) (gi|16078080).","conserved hypothetical protein (possible transmembrane protein)","Membrane, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins and transmembrane proteins; e.g. residues 1-730 are 38% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675912); residues 4-802 are 31% similar to hypothetical protein of Lactococcus lactis (gi|15672864); residues 4-232 are 46% similar to transmembrane protein Tmp7 of Lactococcus lactis (gi|3043882).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2134 (1e-155).","

noIPR
unintegrated

unintegrated
SSF101967	$\"[159-284]T$	SSF101967

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 494-580 are 37% similar to a (CG2779 LIPOPROTEIN CIRCUMSPOROZOITE) protein domain (PD013071) which is seen in Q9RY75_DEIRA.Residues 6-185 are 51% similar to a (PROTEOME COMPLETE INFECTION PHAGE) protein domain (PD014460) which is seen in Q9CH57_LACLA.Residues 610-802 are 36% similar to a (COMPLETE PROTEOME PHAGE INFECTION) protein domain (PD144002) which is seen in Q9CH57_LACLA.Residues 515-580 are 48% similar to a (PROTEOME COMPLETE YJAE CHEMOTAXIS) protein domain (PD248995) which is seen in Q9CH57_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 15:57:37 2002","Wed Jan 2 10:26:04 2002","Wed Jan 2 10:26:04 2002","Wed Jan 2 10:26:04 2002","","Wed Jan 2 10:26:04 2002","yes","Fri Feb 20 15:41:32 MST 1998","SMu1935 is paralogously related (blast p-value < 1e-3) to SMu0018, a predicted immunodominant glycoprotein IDG-60; general stress protein GSP-781; glucan binding protein B; SMu1000, a predicted ABC transporter permease protein and SMu0897, a predicted wall-associated protein A precursor.","Mon Apr 15 15:57:37 2002","","No significant hits to the NCBI PDB database.","SMU.2133c","","No significant hits to the Pfam 11.0 database","Wed Jan 2 10:26:04 2002","24380463","","","","","","1","","","SMU.2133c","204" "SMu1936","1998640","1999194","555","ATGAAAAACACAAAAAAAGAAAAAACAAAGCAAGCTCTTGAAAAAGCCATGGCACATTTATTAGAGAGAGAAAATTTTAATGATATCACAACGACTGAACTAGCAAAAGCAGCTCATATCAGTCGCAGTGGTTTTTATACTCATTATAAAGATAAATATGAGATGATCGATATCTATCAACAAACACTTTTTAGTAAATTAGAATATATTTTTGATAAGAATTCAGCTAACCAAGAAGGCGCTATTTTAGAAGTATTTGAATTCCTTAACCGAGAGCCCTTATTTGCTGCTTTACTTTCAGAAAATGGCACTAAAGAAATTCAAGAATTTCTTAAAAATAAATTTAAAATCCTAATTACGCAAGATTTACAATATGGTCTTTCTATTACTATTCAAAATAGCTTTCACAATAAAAAACTGACAGATGTCGAAAAAGAATATGGAACTATGTATGTTACTAACGCTTTATTTGGTGTCTGTCAAATGTGGATTGCTCGAGGAAAGATAGAAAGTCCTAGGCAAATGACCAATTTCATTATTAAAATGATGCATTAA","9.00","3.16","21556","MKNTKKEKTKQALEKAMAHLLERENFNDITTTELAKAAHISRSGFYTHYKDKYEMIDIYQQTLFSKLEYIFDKNSANQEGAILEVFEFLNREPLFAALLSENGTKEIQEFLKNKFKILITQDLQYGLSITIQNSFHNKKLTDVEKEYGTMYVTNALFGVCQMWIARGKIESPRQMTNFIIKMMH","1999206","","transcriptional regulator, TetR/AcrR family","Cytoplasm","Few moderate matches in gapped BLAST to transcriptional regulators; e.g. residues 5-183 are 59% similar to putative transcriptional regulator (TetR/AcrR family) of Streptococcus pyogenes (gi15675913); residues 3-184 are 43% similar to transcriptional regulator of Lactococcus lactis (gi15672863).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2135 (2e-50).","

InterPro
IPR001647
Domain

Bacterial regulatory protein, TetR
PF00440	$\"[20-57]T$	TetR_N
PS50977	$\"[7-67]T$	HTH_TETR_2

InterPro
IPR009057
Domain

Homeodomain-like
SSF46689	$\"[6-78]T$	Homeodomain_like

InterPro
IPR012287
Domain

Homeodomain-related
G3DSA:1.10.10.60	$\"[6-70]T$	Homeodomain-rel

","BeTs to 6 clades of COG1309COG name: Transcriptional regulators, AcrR familyFunctional Class: KThe phylogenetic pattern of COG1309 is a-T--QVCEBRH---------Number of proteins in this genome belonging to this COG is 18","***** IPB001647 (Bacterial regulatory proteins, TetR family) with a combined E-value of 5.1e-06. IPB001647 25-55","Residues 3-183 are 43% similar to a (PROTEOME COMPLETE TRANSCRIPTIONAL) protein domain (PD106875) which is seen in Q9CH58_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 14:23:58 2002","Tue Jul 18 10:53:57 2006","Tue Jul 18 10:53:57 2006","Mon Apr 15 15:59:41 2002","Wed Jan 2 10:09:24 2002","Wed Jan 2 10:09:24 2002","yes","Thu Oct 10 14:25:40 2002","SMu1936 is paralogously related (blast p-value < 1e-3) to SMu1069, SMu1750, SMu1440, SMu0466, SMu1171, SMu0398, SMu1139, and SMu1243, most of which are predicted transcriptional regulators of the TetR/AcrR family.","Mon Apr 15 15:59:41 2002","","No significant hits to the NCBI PDB database.","SMU.2134","","No significant hits to the Pfam 11.0 database","Wed Jan 2 10:09:24 2002","24380464","","","","","","1","","","SMU.2134","868" "SMu1937","1999847","1999236","612","ATGTCACGTTATACAGGACCATCATGGAAAAAATCACGTCGCCTTGGCTTGTCTCTTACAGGCACAGGTAAAGAATTAGCACGTCGTAACTACGTGCCAGGTCAACATGGACCAAACAACCGCAGCAAACTTTCAGAATATGGTTTGCAATTAGCTGAGAAACAAAAGCTTCGTTTCTCATATGGACTTGGTGAAAAACAATTCCGTAATCTCTTCGTTCAAGCAACTAAAATTAAAGGTGGAATCCTTGGTTACAACTTTATGCTTCTTCTTGAACGTCGTCTTGACAATGTTGTTTACCGTCTTGGTTTAGCAACGACTCGTCGTCAAGCTCGTCAATTTGTAAATCACGGTCACATTCTTGTTGATGGTAAACGTGTTGATATTCCATCATACCGCGTTGAAGTTGGTCAAGTGATTTCAGTTCGTGAAAAATCAGCTAAGGTACCAGCTATTCTTGAAGCTGTTGAATCTGTAGTAGGACGTCCAGCATTCGTATCCTTTGATGCTGACAAACTTGAAGGTTCATTGACACGTCTTCCAGAACGTGATGAAATCAACCCAGAAATTAACGAAGCCCTTGTCGTTGAATTTTATAACAAAATGCTTTAA","10.90","13.72","23019","MSRYTGPSWKKSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGLGEKQFRNLFVQATKIKGGILGYNFMLLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVEVGQVISVREKSAKVPAILEAVESVVGRPAFVSFDADKLEGSLTRLPERDEINPEINEALVVEFYNKML","1999254","For other 'rps' genes see SMu0742 (rpsU); SMu0137 (rpsO);SMu153 (rpsI); SMu0788 (rpsP);SMu1841 (rps10); SMu1838 (rps19);SMu0322 (rpsL); SMu0323 (rpsG); SMu1030 (rpsT); SMu1097 (rpsA); SMu1692 (rpsR) and SMu1694 (rpsF).For other 'rs' genes see SMu1847 (rs2); SMu1836 (rs3); SMu1833 (rs17); SMu1829 (rs14); SMu1828 (rs8); SMu1825 (rs5) SMu1819 (rs13); SMu1818 (rs11); SMu1692 (rs18) and SMu1694 (rs6). From GenBank (gi:133949): This protein binds directly to 16S ribosomal RNA. Protein S4 is also a translational repressor protein; it controls the translation of the alpha-operon (that codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA. It contains one S4 RNA-binding domain and belongs to the S4P family of ribosomal proteins.","30S Ribosomal protein S4","Cytoplasm","Numerous strong matches in gapped BLAST to 30S Ribosomal protein S4; e.g. residues 1-203 are 94% similar to 30S ribosomal protein S4 of Streptococcus pyogenes (gi|15675914); residues 1-201 are 67% similar to 30S ribosomal protein S4 of Bacillus subtilis (gi|133949).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2137 (1e-107).","

InterPro
IPR001912
Family

Ribosomal protein S4
PTHR11831	$\"[90-134]T$	Ribosomal_S4
PF00163	$\"[2-92]T$	Ribosomal_S4
PS00632	$\"[91-115]T$	RIBOSOMAL_S4

InterPro
IPR002942
Domain

RNA-binding S4
PF01479	$\"[93-140]T$	S4
SM00363	$\"[93-157]T$	S4
PS50889	$\"[93-156]T$	S4

InterPro
IPR005709
Family

Ribosomal protein S4, bacterial and organelle form
TIGR01017	$\"[3-201]T$	rpsD_bact

noIPR
unintegrated

unintegrated
G3DSA:3.10.290.10	$\"[92-201]T$	G3DSA:3.10.290.10
PTHR11831:SF4	$\"[90-134]T$	PTHR11831:SF4
SSF55174	$\"[2-201]T$	SSF55174

","BeTs to 17 clades of COG0522COG name: Ribosomal protein S4 and related proteinsFunctional Class: JThe phylogenetic pattern of COG0522 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001912 (Ribosomal protein S4) with a combined E-value of 2.1e-33. IPB001912 80-134 IPB001912 73-127","Residues 42-140 are 41% similar to a (RIBOSOMAL S4 MITOCHONDRION MITOCHONDRIAL) protein domain (PD020805) which is seen in RT04_PROWI.Residues 1-66 are 56% similar to a (RIBOSOMAL CHLOROPLAST S4 30S) protein domain (PD001572) which is seen in RR4_PORPU.Residues 37-157 are 32% similar to a (NAM9 PEPTIDE PRECURSOR TRANSIT) protein domain (PD128153) which is seen in NAM9_YEAST.Residues 67-123 are 80% similar to a (RIBOSOMAL 30S RRNA-BINDING CHLOROPLAST) protein domain (PD004849) which is seen in Q9CIS2_LACLA.Residues 2-66 are 87% similar to a (RIBOSOMAL 30S RRNA-BINDING PROTEOME) protein domain (PD403794) which is seen in Q9CIS2_LACLA.Residues 75-123 are 59% similar to a (RIBOSOMAL CHLOROPLAST SMALL S4) protein domain (PD336381) which is seen in RR4_ARATH.Residues 125-203 are 83% similar to a (RIBOSOMAL 30S RRNA-BINDING PROTEOME) protein domain (PD015784) which is seen in Q9CIS2_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 13:27:26 2002","Mon Dec 24 15:38:16 2001","Mon Dec 24 15:38:16 2001","Thu Apr 4 14:51:05 2002","Mon Dec 24 15:38:16 2001","Mon Dec 24 15:38:16 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1937 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Apr 4 14:51:05 2002","Mon Dec 24 15:38:16 2001","pdb|1EG0|A Chain A, Fitting Of Components With Known Structure ... 199 2e-052pdb|1FKA|D Chain D, Structure Of Functionally Activated Small R... 189 3e-049pdb|1FJF|D Chain D, Structure Of The Thermus Thermophilus 30s R... 186 2e-048","SMU.2135c","","Residues 2 to 92 (E-value = 5.3e-26) place SMu1937 in the Ribosomal_S4 family which is described as Ribosomal protein S4/S9 N-terminal domain (PF00163)Residues 93 to 140 (E-value = 6e-24) place SMu1937 in the S4 family which is described as S4 domain (PF01479)","Mon Dec 24 15:38:16 2001","24380465","","","Grundy,F.J. and Henkin,T.M. Cloning and analysis of the Bacillus subtilis rpsD gene, encoding ribosomal protein S4. J. Bacteriol. 172 (11), 6372-6379 (1990) PubMed: 1699930Grundy,F.J. and Henkin,T.M. The rpsD gene, encoding ribosomal protein S4, is autogenously regulated in Bacillus subtilis. J. Bacteriol. 173 (15), 4595-4602 (1991) PubMed: 1906866Higo,K., Otaka,E. and Osawa,S. Purification and characterization of 30S ribosomal proteins from Bacillus subtilis: correlation to Escherichia coli 30S proteins. Mol. Gen. Genet. 185 (2), 239-244 (1982) PubMed: 6806564","","Mon Dec 24 15:38:16 2001","1","","","SMU.2135c","497" "SMu1938","2000127","1999951","177","ATGTCTGCCCTTGAAAATGAACAAGAAATAATGTATGGCACAGCATATCTCGTTCTTAAAAAACTGAGATACATTCCTATGAAAAGTTTGGCTTTACAAAGCCTTTTTTCTATGTTACAATACTTTTTGTGTGAAATAGCAGCAGAAGAATATGGAGCTCGTCAACAGGTGTCTTAG","5.00","-1.06","6696","MSALENEQEIMYGTAYLVLKKLRYIPMKSLALQSLFSMLQYFLCEIAAEEYGARQQVS","1999969","","hypothetical protein","Cytoplasm","No significant hits using gapped BLAST.SMu1938 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","No hits reported.","No hits to the COGs database.","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:40:52 2002","Mon Dec 24 15:29:12 2001","Mon Dec 24 15:29:12 2001","Mon Dec 24 15:29:12 2001","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1938 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:40:52 2002","","No significant hits to the NCBI PDB database.","SMU.2136c","","No significant hits to the Pfam 11.0 database","Mon Dec 24 15:29:12 2001","24380466","","","","","","1","","","SMU.2136c","" "SMu1939","2000419","2000147","273","ATGAGTGACGCATTTGCAGATGTTGCCAAAATGAAAAAAATAAAAGAAGATATTAAGGCTCATGAAGGTCAAAAAGTTGAATTGACCCTTGAAAATGGGCGTAAGCGTGAAAAAAATAAAATTGGTCGTTTAATTGAAGTCTATTCATCTTTATTTATTGTAGAATACAAGGATAAAGCTTCTGTTCCGGGTGAGATTGATAATACCTATGTAGAATCATACACTTATTCAGATATTCTGACTGAGAAAACATTAATACGTTATTTTGATTAG","6.00","-0.77","10439","MSDAFADVAKMKKIKEDIKAHEGQKVELTLENGRKREKNKIGRLIEVYSSLFIVEYKDKASVPGEIDNTYVESYTYSDILTEKTLIRYFD","2000165","","conserved hypothetical protein","Cytoplasm","Three matches in gapped BLAST to conserved hypothetical proteins; e.g. residues 1-90 are 86% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675916).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2138 (3e-44).","

InterPro
IPR009366
Family

Protein of unknown function DUF1021
PF06257	$\"[11-90]T$	DUF1021

noIPR
unintegrated

unintegrated
PD061839	$\"[1-82]T$	PD061839

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 1-88 are 38% similar to a (PROTEOME COMPLETE YHFC) protein domain (PD391806) which is seen in Q9CHI4_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:39:39 2002","Mon Dec 24 15:28:01 2001","Tue Oct 8 13:39:39 2002","Mon Dec 24 15:28:01 2001","","Mon Dec 24 15:28:01 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1939 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:39:39 2002","","No significant hits to the NCBI PDB database.","SMU.2137c","","Residues 11 to 90 (E-value = 3e-44) place SMu1939 in the DUF1021 family which is described as Protein of unknown function (DUF1021) (PF06257)","Mon Dec 24 15:28:01 2001","24380467","","","","","","1","","","SMU.2137c","989" "SMu1940","2001797","2000433","1365","GTGCCAGAGACCTCAGAATTACGAGTACAGCCTCAAGATTTAATTGCGGAACAATCTGTTTTAGGTTCTGTTTTTATATCACCAGAGAAATTGATTGCTGTTCGGGAATATATTGATCCTGAAGATTTTTATAAATATGCTCATCGTGTTATTTTTAAAGCGATGATTAGTCTTAGTGATCAAAACGATGCCATTGATGCAACAACAGTTCGTGCTATTCTTGATAATCAAGGAGATCTTCAGAATATTGGTGGAATTTCCTATCTGGTTGAATTGGTTAATAGCGTGCCAACCAGTGCTAATGCTGAGTATTATGCTAAAATTGTAGCTGAAAAGGCTATGCTTCGGCGGATTATTTCACGCTTGACAGAAGCTGTTAATCAAGCTTACGAAGGCGCAATAAACTCTGAAGATATTATTTCAGGTGCGGAAAAAGCCCTGATTGATGTTAATGAGCGCAGTAATCGTAGTGGATTTCGTAAAATTTCAGATGTTCTTGCTGTCAATTATGAAAATTTAGAAGTTCGTTCTCAGCAAATAACAGATGTTACAGGACTGGCTACTGGTTTTCGGGATCTTGATAAGATTACAACAGGTTTACACCCAGATCAACTTATTATTTTAGCTGCTAGGCCAGCGGTAGGTAAGACGGCTTTTGTTCTTAATATTGCCCAAAATGTTGGCACTAAAATGAATCGTCCTGTTGCTATTTTTTCTCTAGAAATGGGAGCTGAAAGTCTAGTTGATCGTATGCTGGCTTCAGAAGGAATGGTTGATGCCCATAATTTACGAACAGGTCAGTTAACCGAACAGGATTGGCAAAATATAACGCTTGCGCAAGGGACTCTAGCTGATGCACCAATTTATATTGATGACACTCCGGGAATCAAGGTTACAGAGATTAGGGCACGTGCTCGAAAATTAGATCAGGAACTAGAGAAAGGATTAGGATTAATTGTCATTGACTACTTGCAATTAATCACAGGCACACGACCTGAAAATCGCCAACAAGAAGTGTCTGATATTTCGCGTCAGTTAAAAATTCTTGCTAAGGAACTTGGAGTTCCTGTCATTGCTCTTAGTCAGCTATCTCGTGGTGTTGAGCAGCGTCAAGATAAAAGACCTGTTCTTTCTGATATCCGTGAGTCGGGGTCTATAGAACAAGATGCTGATATTGTAGCCTTTCTTTATCGTGATGATTATTACGATAGAGGAGATAAAGATGAAGGGCAAGAACAATTGGTAGATAATACAATAGAGGTTATCTTGGAAAAAAATCGTGCTGGTGCTCGAGGAACAGTAAAATTAATGTTCCAAAAAGAATATAATAAATTTTCTAGTATTGCCCAATTTGAAGAGAGATAG","4.70","-17.22","50575","MPETSELRVQPQDLIAEQSVLGSVFISPEKLIAVREYIDPEDFYKYAHRVIFKAMISLSDQNDAIDATTVRAILDNQGDLQNIGGISYLVELVNSVPTSANAEYYAKIVAEKAMLRRIISRLTEAVNQAYEGAINSEDIISGAEKALIDVNERSNRSGFRKISDVLAVNYENLEVRSQQITDVTGLATGFRDLDKITTGLHPDQLIILAARPAVGKTAFVLNIAQNVGTKMNRPVAIFSLEMGAESLVDRMLASEGMVDAHNLRTGQLTEQDWQNITLAQGTLADAPIYIDDTPGIKVTEIRARARKLDQELEKGLGLIVIDYLQLITGTRPENRQQEVSDISRQLKILAKELGVPVIALSQLSRGVEQRQDKRPVLSDIRESGSIEQDADIVAFLYRDDYYDRGDKDEGQEQLVDNTIEVILEKNRAGARGTVKLMFQKEYNKFSSIAQFEER","2000451","Note: Similarity to DNA polymerase III delta prime subunit is seen but the majority of similarity is seen to replicative DNA helicase.For other 'dna' genes, see SMu0001 (dnaA); SMu0002 (dnaN); SMu0074 (dnaK);SMu075 (dnaJ); SMu0745 (dnaG); SMu1091 (dnaE); SMu1745 (dnaI);SMu1746 (dnaB) and SMu1437 (dnaX) and (dna H).","replicative DNA helicase","Cytoplasm","Numerous strong matches in gapped BLAST to replicative DNA helicase and to DNA polymerase III delta prime subunit ; e.g. residues 1-454 are 81% similar to DNA polymerase III delta prime subunit of Streptococcus pyogenes (gi|15675917); residues 3-452 are 73% similar to replicative DNA helicase of S.pneumoniae (gi|15902010|).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2139 (0.0).","

InterPro
IPR007692
Family

DnaB helicase
TIGR00665	$\"[5-445]T$	DnaB: replicative DNA helicase

InterPro
IPR007693
Domain

DnaB-like helicase, N-terminal
G3DSA:1.10.860.10	$\"[10-112]T$	no description
PF00772	$\"[9-111]T$	DnaB

InterPro
IPR007694
Domain

DnaB-like helicase, C-terminal
PD332834	$\"[288-396]T$	Q8DRS9_STRMU_Q8DRS9;
PF03796	$\"[182-380]T$	DnaB_C
PS51199	$\"[179-452]T$	SF4_HELICASE

InterPro
IPR013173
Domain

DNA primase DnaG, DnaB-binding
SM00766	$\"[16-135]T$	no description

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[169-451]T$	no description

","BeTs to 12 clades of COG0305COG name: Replicative DNA helicaseFunctional Class: LThe phylogenetic pattern of COG0305 is -----qvCeBRhujgpOlinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001198 (DnaB helicase) with a combined E-value of 1.7e-125. IPB001198A 11-21 IPB001198B 97-113 IPB001198C 188-226 IPB001198D 234-273 IPB001198E 315-328 IPB001198F 333-381 IPB001198G 420-445","Residues 188-363 are 52% similar to a (ATP-BINDING DNA-BINDING RECOMBINATION DAMAGE REPAIR) protein domain (PD000229) which is seen in DNAB_SYNY3.Residues 38-174 are 54% similar to a (HELICASE REPLICATIVE REPLICATION) protein domain (PD002663) which is seen in Q9CHI5_LACLA.Residues 381-447 are 60% similar to a (HELICASE REPLICATIVE REPLICATION) protein domain (PD270109) which is seen in Q9CHI5_LACLA.Residues 253-380 are 41% similar to a (HELICASE REPLICATIVE REPLICATION ATP-BINDING DNA-BINDING) protein domain (PD332834) which is seen in O53124_MYCLE.Residues 16-142 are 26% similar to a (DOMAIN OF UNKNO N) protein domain (PD360683) which is seen in Q9X8A4_STRCO.Residues 381-445 are 44% similar to a (PLASMID HELICASE DNA REPLICATIVE) protein domain (PD399735) which is seen in Q9K2D6_CHLPN.Residues 381-448 are 52% similar to a (HELICASE REPLICATIVE PROTEOME COMPLETE) protein domain (PD003017) which is seen in Q9K5Q9_BACHD.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 15:48:12 2002","Thu Mar 28 08:56:19 2002","Thu Mar 28 08:56:19 2002","Thu Mar 28 08:56:19 2002","Mon Dec 24 15:22:27 2001","Mon Dec 24 15:22:27 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1940 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Mar 28 08:56:19 2002","Mon Dec 24 15:22:27 2001","pdb|1JWE|A Chain A, Nmr Structure Of The N-Terminal Domain Of E... 90 4e-019pdb|1B79|B Chain B, N-Terminal Domain Of Dna Replication Protei... 87 5e-018","SMU.2138c","","Residues 9 to 111 (E-value = 2.8e-46) place SMu1940 in the DnaB family which is described as DnaB-like helicase N terminal domain (PF00772)Residues 182 to 380 (E-value = 1e-131) place SMu1940 in the DnaB_C family which is described as DnaB-like helicase C terminal domain (PF03796)","Mon Dec 24 15:22:27 2001","","","","","","","1","","","SMU.2138c","205" "SMu1941","2002270","2001818","453","ATGAAAGTTATTTTTTTAGCAGATGTCAAAGGTAAAGGTAAGAGAGGGGAAGTAAAAGAAGTTTCTACAGGTTATGCTCAGAATTTTTTAATCAAGAAAAATTTGGCTAAGGAAGCCACAAAACAAGCTATTAATGAGTTAAAGGGAAAGCAAAAATCTGAAGAAAAAGCTCAAGCCGAACTTTTAGCTGAGGCTAAAGCAGTTAAAGTTAAACTTGAACAAGAATCAACGCTTGTTCAATTCAGTGAAAAGGTTGGTCCAGATGGTCGTACTTTTGGTTCTATTACAAGTAAAAAAATTTCTGAAGAATTGAACAAACAATTTGGGATCAAACTGGATAAACGTTATATTAAATTAGATCATCCGATTCGAACAATTGGTTTAATTGAAATTCCTGTAAAACTTCACAAAGATATTGATGGCATCATTAAACTTCAAATTAAAGAAGCTTAA","10.50","10.48","16754","MKVIFLADVKGKGKRGEVKEVSTGYAQNFLIKKNLAKEATKQAINELKGKQKSEEKAQAELLAEAKAVKVKLEQESTLVQFSEKVGPDGRTFGSITSKKISEELNKQFGIKLDKRYIKLDHPIRTIGLIEIPVKLHKDIDGIIKLQIKEA","2001836","For other 'rpl' genes see SMu0639 (rplT); SMu0771 (rplU); SMu0152 (rplM);SMu0869 (rplJ); SMu0872 (rpl); SMu1175 (rplS); SMu1480 (rplA) and SMu1481 (rplK).For other 'rl' genes see SMu1819.1 (rl36);SMu1909.1(rl32);SMu0108 (rl28);SMu1840 (rl3);SMu1839 (rl4); SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15) and SMu1816 (rl7).From GenBank (gi:15672727):This protein binds to the 23S RNA.","50S ribosomal protein L9","Cytoplasm","Many matches in gapped BLAST to 50S ribosomal protein L9; e.g. residues 1-150 are 61% similar to 50S ribosomal protein L9 of Streptococcus pyogenes (gi|15675918); residues 1-149 are 37% similar to 50S ribosomal protein L9 of Bacillus subtilis (gi|16081102).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2140 (1e-43).","

InterPro
IPR000244
Family

Ribosomal protein L9
PTHR21368	$\"[1-150]T$	Ribosomal_L9
PF01281	$\"[1-48]T$	Ribosomal_L9_N
PF03948	$\"[62-150]T$	Ribosomal_L9_C
TIGR00158	$\"[1-150]T$	L9
PS00651	$\"[13-40]T$	RIBOSOMAL_L9
SSF55653	$\"[56-150]T$	Ribosomal_L9

InterPro
IPR009027
Domain

Ribosomal protein L9 N-terminal-like
SSF55658	$\"[1-55]T$	L9_N_like

noIPR
unintegrated

unintegrated
G3DSA:3.10.430.100	$\"[60-147]T$	G3DSA:3.10.430.100
G3DSA:3.40.5.10	$\"[1-59]T$	G3DSA:3.40.5.10
PTHR21368:SF17	$\"[1-150]T$	PTHR21368:SF17

","BeTs to 12 clades of COG0359COG name: Ribosomal protein L9Functional Class: JThe phylogenetic pattern of COG0359 is ----yqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB000244 (Ribosomal protein L9) with a combined E-value of 1.1e-31. IPB000244A 1-31 IPB000244B 86-100 IPB000244C 123-147","Residues 1-104 are 37% similar to a (RIBOSOMAL 50S RRNA-BINDING PROTEOME) protein domain (PD003590) which is seen in Q9CHI6_LACLA.Residues 84-148 are 38% similar to a (RIBOSOMAL 50S L9 RRNA-BINDING) protein domain (PD287380) which is seen in RL9_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 24 13:22:04 2002","Mon Dec 24 14:58:47 2001","Thu Oct 24 13:22:04 2002","Thu Apr 4 13:44:31 2002","Mon Dec 24 14:58:47 2001","Mon Dec 24 14:58:47 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1941 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 24 15:14:27 2001","Mon Dec 24 14:58:47 2001","pdb|487D|K Chain K, Seven Ribosomal Proteins Fitted To A Cryo-E... 92 3e-020","SMU.2139c","","Residues 1 to 52 (E-value = 3.1e-22) place SMu1941 in the Ribosomal_L9_N family which is described as Ribosomal protein L9, N-terminal domain (PF01281)Residues 62 to 150 (E-value = 6.9e-20) place SMu1941 in the Ribosomal_L9_C family which is described as Ribosomal protein L9, C-terminal domain (PF03948)","Mon Dec 24 14:58:47 2001","24380469","","","Vorgias,C.E., Kingswell,A.J., Dauter,Z. and Wilson,K.S. Cloning, overexpression, purification and crystallisation of ribosomal protein L9 from Bacillus stearothermophilus. FEBS letters. 286 (1-2), 204-208 (1991) PubMed: 1864369Hoffman,D.W., Davies,C., Gerchman,S.E., Kycia,J.H., Porter,S.J., White,S.W. and Ramakrishnan,V. Crystal structure of prokaryotic ribosomal protein L9: a bi-lobed RNA-binding protein. The EMBO journal. 13 (1), 205-212 (1994) PubMed: 8306963","","Mon Dec 24 15:14:27 2001","1","","","SMU.2139c","740" "SMu1942","2004245","2002272","1974","ATGAAAAGATTTCGTTTTGCCACTAGCCATTTAATCATGATTGGAATGATTTTGTTTGGAATTTTGGCTATTAGTGCGCGTGTTTTTCCAGATTCACCACTGTTAATGTTTATTATTTTTTTGACTTGTGTAGCTGTAATCATACTGTTTTACTATCAAAAGAATATTTATGAAATTTCTGAATTAGAGCAGATTGAACTCTTAAATAGCCAAACTGAAGGTAAGCTGATTACTATGCTTGATCAGATGCCGGTAGGTGTTATTCAATTTGATCCTGAAACAGATAAAATTGAGTGGTTTAATCCTTTTGCAGAGTTAATTTTCACGAAAGAAGATGGTGAATTTGATGGTGAATTTATCAGCAGTGTCATTAAAAATAGAAAAGAAGGTTCTGTTGATCAAACGATGGAAGTTGGGGAGAATAAATATTCTGTTGATATAGATTTAGACAATGGTATTTTTTACTTTTTCAATTTATCCAGAGAAAGTGAGAATCAAAGGCAAGGATTAGATTTACAACCTGTCATTGGTATTATATCTATTGATAATTATGATGATACGATTGAGTCTTTAGCAGATGCAGATGTTTCACAAATTAATGGTTTTATTGCTAATTTTATTTCTGAATTTGCTCAAAGTAGGGAAATTTTTTATCGCCGTGTTAATATGGATCGTTTTTATTTCTTTACAGATTATAGTGTCTTAGATCAACTCATTCAAGATAAATTTGAGGTGTTAGAACAATTTAGAAAAGAGGCTCAAGAGCGCCACCTTCCTTTAACTTTAAGTATGGGGATTTCTTATGGCAATGCAAATCATAGTCAAATTGGACAAATCGCTTTGAAGAATTTGAATATTGCTCTTGTCCGTGGTGGCGACCAAGCTGTTATCCGTGAAAATGACGAACATAAGAAACTGCTTTATTTTGGTGGAGGAACAGTTTCAACTATTAAGCGTTCACGTACTAGGACACGCGCTATGATGACTGCTATTTCTGATAAAATTAAAACAGTAGATAGTGTCTTTGTTGTAGGACATAAAAATCTTGATATGGACGCTTTGGGAGCTTCAGTTGGGATGCAGGCTTTCGCAAACAATATCATTGAACATGCTGCTTATGCTGTCTATGATGAAGATAGTATGAGTCATGATGTAGCAAGAGCTGTCAATCGTTTAAAGGAAGATGGGCATACTCAACTTTTAACAGTCAAAGAGTCTATAGAACAAGTAAGTGATAATTCTCTTCTTGTTATGGTGGATCATTCTAAATTGCAGCTAACGTTGTCAAGAGAGCTTTACAATAAGTTTACAGAAGTTATTGTGATTGATCACCACAGAAGAGATGATGATTTTCCAGAAAATGCTATTTTAACCTTTATTGAGAGTGGAGCAAGCAGTGCTAGTGAATTAGTAACAGAGCTCTTACAGTTCCAAAATGGGAAATACCATCTCAATAAAATTCAAGCTAGTATTGTTATGGCTGGGATTATGCTTGATACAAAAAGTTTCTCGACTCGTGTAACAAGCCGAACCTTTGATGTAGCCAGCTATTTACGTACGCTTGGCAGTGATAATGTTGAAATTCAAAATATTTCAGCTCTTGATTTTGATGAATACCGTTTAATTAATGAACTTATTTTACGTGGCGATCGTATTTTACCAAATGTTGTTGTTGCTACAGGAGCAGATGATATCAGTTATTCCAATGTTATTGCTAGCAAGGCTGCTGATACTATGTTAAATATGGCTGGGATTGAGGCTACCTTTGTTATTACTAGAAATGATGAAAGAACAGTTTGTATATCTGCACGGAGTCGCAATAAAATTAATGTTCAACGGATTATGGAAGAAATGGGAGGCGGCGGCCACTTCAACTTAGCAGCCTGTCAATTAAAAGGTACAAGTGTTAAAGAAGCCCGCAAACTCTTATTAGAAAAGATCAAAGAAGAATTTACAGGAAACGAGGAAGCTTAA","4.80","-25.93","74202","MKRFRFATSHLIMIGMILFGILAISARVFPDSPLLMFIIFLTCVAVIILFYYQKNIYEISELEQIELLNSQTEGKLITMLDQMPVGVIQFDPETDKIEWFNPFAELIFTKEDGEFDGEFISSVIKNRKEGSVDQTMEVGENKYSVDIDLDNGIFYFFNLSRESENQRQGLDLQPVIGIISIDNYDDTIESLADADVSQINGFIANFISEFAQSREIFYRRVNMDRFYFFTDYSVLDQLIQDKFEVLEQFRKEAQERHLPLTLSMGISYGNANHSQIGQIALKNLNIALVRGGDQAVIRENDEHKKLLYFGGGTVSTIKRSRTRTRAMMTAISDKIKTVDSVFVVGHKNLDMDALGASVGMQAFANNIIEHAAYAVYDEDSMSHDVARAVNRLKEDGHTQLLTVKESIEQVSDNSLLVMVDHSKLQLTLSRELYNKFTEVIVIDHHRRDDDFPENAILTFIESGASSASELVTELLQFQNGKYHLNKIQASIVMAGIMLDTKSFSTRVTSRTFDVASYLRTLGSDNVEIQNISALDFDEYRLINELILRGDRILPNVVVATGADDISYSNVIASKAADTMLNMAGIEATFVITRNDERTVCISARSRNKINVQRIMEEMGGGGHFNLAACQLKGTSVKEARKLLLEKIKEEFTGNEEA","2002290","","conserved hypothetical protein (DHH family protein)","Cytoplasm, Membrane","Many matches in gapped BLAST to conserved hypothetical protein; e.g. residues 1-647 are 59% similar to conserved hypothetical protein of Streptococcus pyogenes (gi15675919); residues 44-649 are 43% similar to conserved hypothetical protein of Lactococcus lactis (gi15672726).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2141 (0.0).","

InterPro
IPR001667
Domain

Phosphoesterase, RecJ-like
PF01368	$\"[334-497]T$	DHH

InterPro
IPR003156
Domain

Phosphoesterase, DHHA1
PF02272	$\"[585-645]T$	DHHA1

InterPro
IPR014528
Family

Signal transduction phosphoesterase predicted, YybT type
PIRSF026583	$\"[2-657]T$	YybT

noIPR
unintegrated

unintegrated
G3DSA:3.90.1640.10	$\"[338-537]T$	G3DSA:3.90.1640.10
PTHR13734	$\"[2-639]T$	PTHR13734
PTHR13734:SF2	$\"[2-639]T$	PTHR13734:SF2
SSF55785	$\"[59-124]T$	SSF55785
SSF64182	$\"[339-620]T$	SSF64182

","BeTs to 10 clades of COG0618COG name: Exopolyphosphatase-related proteinsFunctional Class: RThe phylogenetic pattern of COG0618 is aM-K-QVC-Br---GPoL---Number of proteins in this genome belonging to this COG is 2","***** IPB001667 (DHH family) with a combined E-value of 1.9e-08. IPB001667A 348-361 IPB001667B 439-446 IPB001667C 620-628","Residues 417-518 are 59% similar to a (COMPLETE PROTEOME HYDROLASE MANGANESE) protein domain (PD003055) which is seen in Q9CHI7_LACLA.Residues 44-404 are 38% similar to a (PROTEOME COMPLETE BH4031 YHFB) protein domain (PD139984) which is seen in Q9CHI7_LACLA.Residues 413-628 are 25% similar to a (COMPLETE PROTEOME MG371 UU417) protein domain (PD370564) which is seen in Y371_MYCPN.Residues 519-649 are 47% similar to a (PROTEOME COMPLETE BH4031 YHFB) protein domain (PD407587) which is seen in Q9CHI7_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:34:47 2002","Tue Aug 29 09:23:51 2006","Tue Aug 29 09:23:51 2006","Mon Apr 15 16:01:42 2002","Mon Dec 24 14:44:09 2001","Mon Dec 24 14:44:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1942 is paralogously related (blast p-value < 1e-3) to SMu1184, a predicted alcohol-acetaldehyde dehydrogenase and SMu1537, a predicted manganese-dependent inorganic pyrophosphatase.","Mon Apr 15 16:01:42 2002","","No significant hits to the NCBI PDB database.","SMU.2140c","","Residues 334 to 497 (E-value = 6.4e-42) place SMu1942 in the DHH family which is described as DHH family (PF01368)Residues 585 to 645 (E-value = 2.7e-12) place SMu1942 in the DHHA1 family which is described as DHHA1 domain (PF02272)","Tue Aug 29 09:23:51 2006","24380470","","","","","","1","","","SMU.2140c","206" "SMu1943","2006220","2004325","1896","ATGACACACGAATTTACTGAAAACTATGATGTTATTGTCATCGGCGCTGGTCATGCTGGTGTGGAAGCCAGTCTTGCTACTAGTCGTATGGGCTGTAAGACTTTACTGGCAACTATTAATTTGGAAATGTTGGCTTTTATGCCTTGTAATCCTTCAATTGGTGGTTCTGCTAAGGGGATTGTCGTTCGTGAGATTGATGCTCTTGGCGGTGAGATGGGAAAGAATATTGATAAGTCCTATATTCAAATGCGAATGCTCAATACGGGTAAGGGTCCAGCAGTACGTGCTTTACGTGCACAGGCTGATAAGGCACTTTATGCTCGCAACATGAAACATACGGTTGAACAACAGGAAAACTTAACCTTACGTCAATCTATGATTGATGAAATTTTGGTTGAAGATGGTAAAGTTATTGGTGTTAGGACAGCGACGAATCAGAAATACAGCGCTCAGGCTGTCATTGTGACAACTGGTACGGCTTTGCGCGGTGAGATCATTTTAGGCGAATTAAAATATTCATCTGGGCCTAATAATAGTCTCGCTTCAGTAACTTTAGCAGATAATTTGAGAGATTTAGGTCTGGAGATTGGGCGCTTTAAAACGGGGACACCGCCACGAGTTAAGGCTAATTCTATTCATTATGATGAAACTGAAATTCAGCCCGGAGATAAGAAAGCAAATCACTTCTCGTTTATGTCCAAAGATGAAGATTACCTTAAAGATCAGATCCCTTGTTGGCTGACCTATACCAATCAAAGTAGTCATGATATTATTAATAAAAATCTTTACAGAGCACCTATGTTTTCAGGTATTGTCAAGGGTGTAGGACCACGTTATTGTCCTTCTATTGAGGATAAGATTGTCCGTTTTGCTGACAAAGATCGTCATCAGCTTTTTTTAGAGCCTGAAGGACGTGAAACAGAAGAAGTCTATATTCAAGGTCTGTCAACGAGTTTGCCAGAAGATGTTCAAAAAGATGTGGTTCATTCGATTAAAGGACTGGAGAATGCTGAAATGATGCGGACTGGCTATGCCATTGAATATGATATTGTCCTTCCTCATCAATTGCGGGCGACTCTGGAAACCAAAAAAATCTCAGGACTATTTACGGCTGGTCAAACAAATGGGACGTCTGGTTATGAAGAAGCCGCTGGTCAAGGAATTGTCGCTGGTATCAATGCTGCCCTTAAGATTCAAGGAAAACCAGAATTGATTCTCAAACGTAGCGATGCTTATATTGGAGTTATGATTGATGACTTGGTCACGAAAGGAACCCTTGAACCTTATCGTTTACTAACATCGCGTGCGGAGTATCGTTTGATCTTACGTCATGACAATGCAGATTTACGCTTGACAGAAATTGGTCATCAGGTTGGTCTAGTGAATGAAGAACGCTATATGCGCTTCCAAATCCGTAAAAATCAATTTGACAATGAGTTGACAAGGTTGTCAAGTATAAAATTAAAACCAGTTGCTGAAATAAATAAACGTATTGAAGAACTTGGCTTTAAGCCCTTGACAGATGCTTTGACAGCAAAAGAATTTATGCGTCGACCAGAAATCAACTATGCCATTGCAACAAGTTTTGTTGGGCCTGCGGCGGAAAGCTTAGATGAGAAGGTCATTGAACTTCTAGAAACTGAAATCAAATACGAGGGATACATTAATAAAGCCCTAGATCAAGTTGCAAAAATGAAGCGAATGGAAGAAAAACGAATTCCTAAGAATATCGATTGGGATGCCATTGATTCTATTGCGACCGAAGCACGTCAGAAATTTAAGAAAATTAACCCAGAAACTATTGGTCAAGCTAGCCGTATTTCTGGTGTGAATCCAGCTGATATATCAATTCTTATGGTCTATCTTGAAGGAAAGAATAGAAGTCGTACAAGATAA","7.30","1.53","70427","MTHEFTENYDVIVIGAGHAGVEASLATSRMGCKTLLATINLEMLAFMPCNPSIGGSAKGIVVREIDALGGEMGKNIDKSYIQMRMLNTGKGPAVRALRAQADKALYARNMKHTVEQQENLTLRQSMIDEILVEDGKVIGVRTATNQKYSAQAVIVTTGTALRGEIILGELKYSSGPNNSLASVTLADNLRDLGLEIGRFKTGTPPRVKANSIHYDETEIQPGDKKANHFSFMSKDEDYLKDQIPCWLTYTNQSSHDIINKNLYRAPMFSGIVKGVGPRYCPSIEDKIVRFADKDRHQLFLEPEGRETEEVYIQGLSTSLPEDVQKDVVHSIKGLENAEMMRTGYAIEYDIVLPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIVAGINAALKIQGKPELILKRSDAYIGVMIDDLVTKGTLEPYRLLTSRAEYRLILRHDNADLRLTEIGHQVGLVNEERYMRFQIRKNQFDNELTRLSSIKLKPVAEINKRIEELGFKPLTDALTAKEFMRRPEINYAIATSFVGPAAESLDEKVIELLETEIKYEGYINKALDQVAKMKRMEEKRIPKNIDWDAIDSIATEARQKFKKINPETIGQASRISGVNPADISILMVYLEGKNRSRTR","2004343","For other 'gid' genes see SMu0913 (gidA),(gid) and SMu1755 (gidB).","glucose-inhibited division protein A","Cytoplasm","Numerous strong matches in gapped BLAST to glucose inhibited division protein. Residues 1-631 are 88% similar to GidA protein of S. pyogenes (gi15675920). Residues 9-623 are 64% similar to GidA of Bacillus halodurans (gi12643249).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2142 (0.0).","

InterPro
IPR001100
Family

Pyridine nucleotide-disulphide oxidoreductase, class I
PR00411	$\"[10-32]T$ $\"[153-162]T$	PNDRDTASEI

InterPro
IPR002218
Family

Glucose-inhibited division protein A
PD003738	$\"[331-399]T$	GIDA
PTHR11806	$\"[14-629]T$	GIDA
PF01134	$\"[10-402]T$	GIDA
PS01280	$\"[276-290]T$	GIDA_1
PS01281	$\"[371-394]T$	GIDA_2

InterPro
IPR004416
Family

Glucose-inhibited division protein A subfamily
TIGR00136	$\"[9-626]T$	gidA

InterPro
IPR013027
Domain

FAD-dependent pyridine nucleotide-disulphide oxidoreductase
PR00368	$\"[10-32]T$ $\"[153-162]T$	FADPNR

noIPR
unintegrated

unintegrated
G3DSA:3.50.50.60	$\"[4-158]T$	G3DSA:3.50.50.60
SSF51905	$\"[1-427]T$	SSF51905

","BeTs to 12 clades of COG0445COG name: NAD/FAD-utilizing enzyme apparently involved in cell divisionFunctional Class: DThe phylogenetic pattern of COG0445 is ----yqvceb-hujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB002218 (Glucose inhibited division protein A family) with a combined E-value of 3.8e-247. IPB002218A 28-77 IPB002218B 139-176 IPB002218C 178-223 IPB002218D 242-270 IPB002218E 276-304 IPB002218F 314-368 IPB002218G 374-394 IPB002218H 408-451 IPB002218I 573-615","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 09:27:34 2006","Tue Aug 29 09:27:34 2006","Tue Aug 29 09:27:34 2006","Tue Apr 2 14:39:49 2002","Mon Dec 24 13:43:47 2001","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1943 is paralogously related (blast p-value < 1e-3) to SMu0913, a predicted manganese-dependent inorganic pyrophosphatase.","Mon Apr 15 16:02:36 2002","","No significant hits to the NCBI PDB database.","SMU.2141c","","Residues 10 to 409 (E-value = 8.6e-234) place SMu1943 in the GIDA family which is described as Glucose inhibited division protein A (PF01134)","Mon Dec 24 13:43:47 2001","","","","","","","1","","","SMU.2141c","207" "SMu1944","2006979","2006347","633","ATGAAAATTGGTGTTATTCAAGCGAGTACAAGGACAGACCTCAATCAACTTCTTTTTGAGGCGGTCAAACAGGCAGCTGGAAATCAGCATGAAATTGTCAATTTTGGAGTCTTTCCGCAAGAAACTGAAAATTATTCCTATGTTGAAGTGGCTATCATGATTAGTCTACTTATTGAAACTGGGGCTATTGATTTTATGGTTTCTGGTTGCTCGTCTGGTCAAGGAATGATGATGGCATGTAATAGTTTGCCTGGTTTACAAGCTGGTTTTATTCAGACACCACAGGATGCCTTTCTCTTTGGTCGTATCAATAATGGAAATGTTGCTTCACTTTCTCTGGGTTTAAATTTTGGTTGGGCTGGGGAGTTGAATTTGCAATATGCCTTAAATGAGTTATTTCATGGTGAATTCGGTATTGGTTATCCACCAGAAGTAGCTGAGCGAAAACGTGAAGAAGCACAACTTCTACTTACTTTAAATGATATAACTAAAAAATCATTTTTAGAAATTATTGATCAACTTGACAAAGCATTGCTTTTTAAGATTTTAAAAAGAAAAGATTTGACAGCATATCTTTTTGATTACGGGAGCAACTCTCTGTTATTAGAACGATTACAATTTTTTAGAAATTGA","4.70","-6.61","23386","MKIGVIQASTRTDLNQLLFEAVKQAAGNQHEIVNFGVFPQETENYSYVEVAIMISLLIETGAIDFMVSGCSSGQGMMMACNSLPGLQAGFIQTPQDAFLFGRINNGNVASLSLGLNFGWAGELNLQYALNELFHGEFGIGYPPEVAERKREEAQLLLTLNDITKKSFLEIIDQLDKALLFKILKRKDLTAYLFDYGSNSLLLERLQFFRN","2006365","","sugar-phosphate isomerase (ribose 5-phosphate isomerase)","Cytoplasm","Several hits in gapped BLAST to sugar-phosphate isomerases. Residues 1-193 are 32% similar to sugar-phosphate isomerase of Clostridium acetobutylicum (gi15895864). Residues 1-206 are 33% similar to sugar-phosphate isomerase of Streptococcus pyogenes (gi15674708).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1905 (5e-36).","

InterPro
IPR003500
Family

Ribose/galactose isomerase
PF02502	$\"[2-160]T$	LacAB_rpiB

noIPR
unintegrated

unintegrated
G3DSA:3.40.1400.10	$\"[1-112]T$	G3DSA:3.40.1400.10
SSF89623	$\"[1-161]T$	SSF89623

","BeTs to 4 clades of COG0698COG name: Ribose 5-phosphate isomerase RpiBFunctional Class: GThe phylogenetic pattern of COG0698 is -----qvcebr-ujgp----xNumber of proteins in this genome belonging to this COG is 3","No significant hits to the Blocks database.","No significant hits to the ProDom database.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Oct 10 11:16:55 2002","Tue Mar 13 11:28:30 2007","Tue Mar 13 11:28:30 2007","Thu Oct 10 11:13:43 2002","","","yes","Fri Feb 20 15:41:32 MST 1998","SMu1944 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Thu Oct 10 11:13:43 2002","","No significant hits to the NCBI PDB database.","SMU.2142c","","Residues 1 to 210 (E-value = 8.3e-128) place SMu1944 in the DUF1124 family which is described as Putative ribose 5-phosphate isomerase (DUF1124) (PF06562)","Mon Dec 24 13:23:15 2001","","","","","","","1","","","SMU.2142c","" "SMu1945","2008162","2007041","1122","ATGACAGATAATTCAAAAACACGTGTCGTTGTTGGCATGAGTGGTGGTGTTGATTCGTCTGTAACGGCTCTGCTTTTAAAAGAACAAGGTTATGACGTGATTGGTGTCTTCATGAAAAACTGGGACGACACAGATGAATTTGGCGTTTGTACAGCTACAGAAGATTACAAAGATGTGGCTGCGGTAGCAGATCAGATTGGGATTCCTTATTATTCAGTCAATTTTGAAAAAGAGTATTGGGATCGTGTCTTCGAGTATTTCTTGGCAGAATATCGTGCAGGACGCACACCTAATCCAGATGTCATGTGTAACAAGGAAATTAAATTTAAAGCCTTTCTTGATTATGCCATGACCCTTGGTGCGGATTATGTGGCGACTGGACATTATGCGCAAGTGTCACGTGATGCAGACGGGACTGTCCATATGTTGCGCGGAGCAGATAATAACAAGGACCAAACTTATTTTTTAAGTCAGTTATCACAAGAACAGCTGCAAAAGGTAATGTTTCCTTTAGGTCATTTGCAAAAGCCGCGAGTTCGTGAAATTGCAGAGAAGGCAGGATTGGTAACAGCTAAGAAAAAAGATTCAACAGGAATATGCTTTATTGGTGAAAAGAATTTTAAAGAGTTTTTGAGTAGCTATTTGCCGGCTCAAAAAGGTCGTATGATGACTATTGATGGTCGTGATATGGGAGAACATAATGGATTAATGTACTATACCATTGGTCAACGTGGCGGCATGGGAATCGGTGGGCAAAAAGGTGGAGATAATGCACCTTGGTTTGTTGTAGGGAAAGATTTGTCTCAAAATATTCTCTACGTTGGGCAAGGTTTCTATCATGACGCACTTATGTCAACCAGCTTGACAGCTAGTCAGGTTCATTTTACACAAAATATGCCAGATAAGTTTACACTAAATTGCACAGCTAAGTTTCGTTATCGTCAACCAGATAGTAAAGTAGATGTCAAGGTAAACGGTGACAAAGCAGAAGTTATTTTCGATGAACCTCAACGTGCTATCACACCTGGTCAAGCAGTTGTTTTCTATGATGGAGATGAATGTCTTGGCGGTGGTCTTATTGACAATGCCTATCAAGAAGAAAAAATTTGTCAGTATATCTAA","5.10","-8.82","41677","MTDNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGVFMKNWDDTDEFGVCTATEDYKDVAAVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRAGRTPNPDVMCNKEIKFKAFLDYAMTLGADYVATGHYAQVSRDADGTVHMLRGADNNKDQTYFLSQLSQEQLQKVMFPLGHLQKPRVREIAEKAGLVTAKKKDSTGICFIGEKNFKEFLSSYLPAQKGRMMTIDGRDMGEHNGLMYYTIGQRGGMGIGGQKGGDNAPWFVVGKDLSQNILYVGQGFYHDALMSTSLTASQVHFTQNMPDKFTLNCTAKFRYRQPDSKVDVKVNGDKAEVIFDEPQRAITPGQAVVFYDGDECLGGGLIDNAYQEEKICQYI","2007059","For other 'trm' genes see SMu0147 (trmH) and SMu0791 (trmD).From GenBank (gi:14195271): In L. lactis, this enzyme catalyzes the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. It is cytoplasmic and belongs to the TrmU family.Note tandem repeats at 2007245,2007295.","tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase","Cytoplasm","Numerous strong hits in gapped BLAST to tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferases. Residues 1-373 are 82% similar to tRNA-methyltransferase of Streptococcus pneumoniae (gi|15902166). Residues 5-372 are 74% similar to tRNA-methyltransferase of Lactococcus lactis (gi|15672819).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2144 (1e-179).","

InterPro
IPR004506
Family

tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
PTHR11933	$\"[22-373]T$	TrmU_mtfrase
PF03054	$\"[7-360]T$	tRNA_Me_trans
TIGR00420	$\"[7-360]T$	trmU

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[8-188]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
SSF52402	$\"[5-249]T$	SSF52402

","BeTs to 12 clades of COG0482COG name: Predicted ATPase of the PP-familyFunctional Class: RThe phylogenetic pattern of COG0482 is ----yQvcebrhUJgpo-inxNumber of proteins in this genome belonging to this COG is 1","***** IPB003694 (NAD+ synthase) with a combined E-value of 6.7e-06. IPB003694A 10-29","Residues 171-361 are 78% similar to a (TRNA METHYLTRANSFERASE) protein domain (PD005022) which is seen in TRMU_STRPY.Residues 22-135 are 98% similar to a (TRNA METHYLTRANSFERASE) protein domain (PD000352) which is seen in TRMU_STRPY.Residues 87-170 are 35% similar to a (TRNA METHYLTRANSFERASE) protein domain (PD391898) which is seen in TRMU_THEMA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 30 11:29:11 2002","Mon Dec 24 13:14:32 2001","Wed Oct 30 11:29:11 2002","Mon Apr 8 08:46:56 2002","Mon Dec 24 13:14:32 2001","Mon Dec 24 13:14:32 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1945 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Apr 8 08:46:56 2002","","No significant hits to the NCBI PDB database.","SMU.2143c","","Residues 7 to 360 (E-value = 1.1e-221) place SMu1945 in the tRNA_Me_trans family which is described as tRNA methyl transferase (PF03054)","Mon Dec 24 13:14:32 2001","24380473","","","","","","1","","","SMU.2143c","208" "SMu1946","2009136","2008531","606","ATGTATAGTAGAGTCAAAAAATCGAAATTCAGAAAAATGCTGAAAAGTCAATTTTGGGTTTTACCTTTTTTTGTAGGGTTTGCCTCCTTTTTTACAGGTGAATCAGTTAATACAGAAGCACATATTAAAAAATCAGAATCTGTTCTTGCTCACACTGCACAAGCTCAAGAAGTAAGCCAAGATCAACAGACAACTTCCGCTGAACTGACCTCCGCTCCTTCAGAAGCAGCCTCTTCAGAAGCAATAACAGAGGTTGCAGCAACTGAACCAACTGATAATGTCAATTATAATACAGCTTATGCTTCTCAGGCAGCTCAAGTAGCTAATGTCAATCATAATGGTAATCTTGCTAATGGCAACACTGCTGGTGCAACTGGTTCAGAAGCAGCGGCTCAAATGGCAGCAGCAACTGGGGTTTCTCAGTCAACTTGGGAATATATTATTGCACGGGAATCAAATGGTCAAGTCACTGCAGCTAATGGTTCAGGAGCTTCAGGTCTCTTTCAAACAATGCCTGGTTGGGGTTCAACTGCAACAGTTCAAGATCAGGTTAATTCAGCTATCAATGCTTATAAAGCCCAAGGTTTATCAGCTTGGGGCATGTAA","5.30","-3.28","21017","MYSRVKKSKFRKMLKSQFWVLPFFVGFASFFTGESVNTEAHIKKSESVLAHTAQAQEVSQDQQTTSAELTSAPSEAASSEAITEVAATEPTDNVNYNTAYASQAAQVANVNHNGNLANGNTAGATGSEAAAQMAAATGVSQSTWEYIIARESNGQVTAANGSGASGLFQTMPGWGSTATVQDQVNSAINAYKAQGLSAWGM","2008549","No hits in gapped BLAST to the first 138 amino acids of this protein.","conserved hypothetical protein","Extracellular","Few partial weak hits in gapped BLAST to hypothetical proteins and immunodominant antigens. Residues 139-200 are 82% similar to hypothetical protein of Streptococcus pyogenes (gi15675925). Residues 139-200 are 75% similar to immunodominant antigen A of Staphylococcus aureus (gi15925559).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2147 (2e-26).","

InterPro
IPR010618
Domain

Transglycosylase-like
PF06737	$\"[138-201]T$	Transglycosylas

noIPR
unintegrated

unintegrated
SSF53955	$\"[124-193]T$	SSF53955

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 139-200 are 75% similar to a (A SAI-B SECRETORY ANTIGEN) protein domain (PD356433) which is seen in Q9LAB6_STAAU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 16:05:08 2002","Thu Sep 21 08:43:49 2006","Thu Sep 21 08:43:49 2006","Mon Dec 24 13:07:03 2001","","Mon Dec 24 13:07:03 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1946 is paralogously related (blast p-value < 1e-3) to SMu1947 ,a predicted surface protein; SMu0999,a predicted conserved hypothetical; possible sr and SMu0018, a predicted glucan-binding protein B;immunodominant glycoprotein IDG-60; general stress protein GSP-781. ","Mon Apr 15 16:05:08 2002","","No significant hits to the NCBI PDB database.","SMU.2146c","","Residues 132 to 201 (E-value = 6.2e-21) place SMu1946 in the Transglycosylas family which is described as Transglycosylase-like domain (PF06737)","Mon Dec 24 13:07:03 2001","24380474","","","","","","1","","","SMU.2146c","990" "SMu1947","2010164","2009298","867","ATGTCTATTAAAAATATTTTAGAAAACAAAACAACAACAATTAAAGTTAGTTTTGCAGGAATTGCAACAGCAGCTAGTTTAATTTTACCTATGGCAGTACAGGCAGAAACTACTTATACTGTGAAATCAGGAGATACTTTATCAGAGATTGCTTCAACACACGGAACAACTGTTGATAAACTTGCTAAGTTAAATAAAATTAATAATATCCATCTTATCCATGCTGGTCAAATTTTAGAATTAGATGCAGCAACAGAAGATACTGATGCAACGCCAGTACAAGAAAGTCAGATAAATGAAGCAGAAACCTCAGCATCTGCCAAAACTAGTCAAACGAGCGAAGTGACGACAACAGCACCGGTACAAGAAAGCCAAACAAGTGAAGTTATAACTTCAGCACCAGCTGAAACCAGTCAGACAAGCGAAGTGCCAACTGAAGCCAACCAAACAAATGAAGTAAGTTCAGCAGTATCGGTTGAAACCAGTCAAACGAGTGAGGCGACGACTTCAGCTCCAGTGGAAACTAGTCAGACAAGCGAAGCAACGACAGCGGAACCAACTGAGACCAAGACCAGCCAAACAAATGAAGTAGCAGCTTCAGCTGAAGAAAACCAAACAACATCTAATACTAGCGGTTTGAGCACATCTGATGCAGCTGCAAAAGAATTCATCGCTCAAAAAGAATCAGGTGGTAATTATAATGCTAAAAATGGTCAATATTATGGACGTTATCAATTGAGTGATTCTTACTTGAATGGTGATTTGTCAGAAGAAAATCAAGAACGTGTAGCAGATGCTTATGTATCAAGTCGTTATGGTTCATGGACTGCTGCTCAAGCTTTCTGGAATGCTAATGGTTGGTATTAA","4.10","-22.25","30457","MSIKNILENKTTTIKVSFAGIATAASLILPMAVQAETTYTVKSGDTLSEIASTHGTTVDKLAKLNKINNIHLIHAGQILELDAATEDTDATPVQESQINEAETSASAKTSQTSEVTTTAPVQESQTSEVITSAPAETSQTSEVPTEANQTNEVSSAVSVETSQTSEATTSAPVETSQTSEATTAEPTETKTSQTNEVAASAEENQTTSNTSGLSTSDAAAKEFIAQKESGGNYNAKNGQYYGRYQLSDSYLNGDLSEENQERVADAYVSSRYGSWTAAQAFWNANGWY","2009316","","conserved hypothetical protein","Extracellular, Cellwall","Few partial weak hits in gapped BLAST to hypothetical proteins and proteins of various functions. Residues 197-288 are 64% similar to LysM domain protein of Streptococcus pneumoniae (gi|15900050). Residues 71-288 are 35% similar to aggregation promoting protein of Lactobacillus gasseri (gi|1619598). Also similar to putative lipoprotein of Escherichia coli (gi|16130767).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2148 (3e-32).","

InterPro
IPR002482
Domain

Peptidoglycan-binding LysM
PF01476	$\"[39-82]T$	LysM
SM00257	$\"[38-82]T$	LysM

InterPro
IPR010618
Domain

Transglycosylase-like
PF06737	$\"[215-279]T$	Transglycosylas

noIPR
unintegrated

unintegrated
G3DSA:3.10.350.10	$\"[35-84]T$	G3DSA:3.10.350.10
SSF54106	$\"[35-84]T$	SSF54106

","BeTs to 3 clades of COG0739COG name: Membrane proteins related to metalloendopeptidasesFunctional Class: MThe phylogenetic pattern of COG0739 is -----QVCEBRHUJ--OL--XNumber of proteins in this genome belonging to this COG is 1","No significant hits to the Blocks database.","Residues 206-288 are 67% similar to a (PRECURSOR PROMOTING SCEA AGGREGATION) protein domain (PD030325) which is seen in P71433_BBBBB.Residues 6-219 are 21% similar to a (GP7) protein domain (PD325028) which is seen in Q9G0H8_VVVVV.Residues 12-146 are 27% similar to a (STREPTOCOCCAL B IMMUNOGENIC SURFACE) protein domain (PD332802) which is seen in Q54524_STRPY.Residues 35-79 are 60% similar to a (PROTEOME COMPLETE HYDROLASE LATE) protein domain (PD104482) which is seen in Q9T1Z3_VVVVV.Residues 39-81 are 58% similar to a (CELL PROTEOME COMPLETE PRECURSOR) protein domain (PD407905) which is seen in P60_LISIV.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:32:09 2002","Mon Dec 24 13:02:08 2001","Mon Dec 24 13:02:08 2001","Mon Apr 15 16:13:05 2002","","Mon Dec 24 13:02:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1947 is paralogously related (blast p-value < 1e-3) to SMu0897, a predicted wall-associated protein A precursor; SMu0827,a predicted glucosyltransferase-S; SMu0332,a predicted streptococcus-specific conserved hypothetical protein; similar to glucan-binding protein; SMu0999,a predicted conserved hypothetical; possible sr; SMu0630,a predicted hypothetical protein; SMu0631,a predicted hypothetical protein; SMu1575,a predicted aminodeoxychorismate lyase-like protein (fragment); SMu0915,a predicted glucosyltransferase-SI; SMu1946,a predicted conserved hypothetical protein (possible immunodominant antigen); SMu1843,a predicted levansucrase (fructosyltransferase) (beta-D-fructofuranosyl transferase; SMu0057,a predicted conserved hypothetical protein; SMu1916,a predicted glucan-binding protein; SMu0070, a predicted fructan hydrolase; exo-beta-D-fructosidase; SMu1729, a predicted hypothetical protein and SMu0914, a predicted glucosyltransferase-I.","Mon Apr 15 16:13:05 2002","","No significant hits to the NCBI PDB database.","SMU.2147c","","Residues 39 to 82 (E-value = 8.1e-16) place SMu1947 in the LysM family which is described as LysM domain (PF01476)","Mon Dec 24 13:02:08 2001","24380475","","","","","Tue Oct 8 13:32:09 2002","1","","","SMU.2147c","991" "SMu1948","2011147","2010353","795","ATGGCTAATCTTATCCTTGGGCGATATATTCCAGGTGATTCTTTCGTTCATCGACTGGATCCGAGAAGTAAATTGTTATCAATGCTTATTTTCATTATTGTCGTTTTTTGGGCTAATAATGTTCTTACAAATCTTTTGATGTTCGTCTTTACGATGATTCTGGTCTTTCTATCACGCGTAAAAATTAGTTTTTTTCTAAAGGGATTGAGACCGATGATTGGTTTAATCCTCTTTACAACGCTTTTTCAAGTTCTTTTTACACAGAATGGCCATGTTTTATTTCATTTATGGATTATCAAAATAACTGATTCTGGTATTGGGCAGGCAGCTTTGATTTTTATGCGTTTTGTTTTAATCATTATTTTTTCAACGCTTTTAACTTTGACAACAACGCCACTCAGTTTAGCAGATGCAGTCGAATCACTTTTAAAACCTTTAGAACCCTTAAAAGTACCTGTTCATGAAATTGGTTTAATGCTATCATTAAGTTTACGATTTGTTCCAACCCTGATGGATGATACAACACGAATTATGAATGCTCAAAGAGCACGCGGTGTCGATTTTGGTGAAGGAAATTTGATACAAAAAATTAAATCTATCATTCCTATTTTAATTCCGCTTTTTGCATCTAGTTTTAAAAGGGCAGATGCTTTAGCAACAGCAATGGAAGCGCGTGGTTATCAAGGTGGTGCAGGACGTAGCAAATACCGTTTATTAAAATGGACTTATAAAGACAGCTTGGCTATTGTTGGTATTTGTTTGCTTGGTTTTATTTTATTTTTATTAAAAAAATGA","11.10","14.90","29662","MANLILGRYIPGDSFVHRLDPRSKLLSMLIFIIVVFWANNVLTNLLMFVFTMILVFLSRVKISFFLKGLRPMIGLILFTTLFQVLFTQNGHVLFHLWIIKITDSGIGQAALIFMRFVLIIIFSTLLTLTTTPLSLADAVESLLKPLEPLKVPVHEIGLMLSLSLRFVPTLMDDTTRIMNAQRARGVDFGEGNLIQKIKSIIPILIPLFASSFKRADALATAMEARGYQGGAGRSKYRLLKWTYKDSLAIVGICLLGFILFLLKK","2010371","For other components see SMu1950 (NBD1) and SMu1949 (NBD2).","ABC transporter, membrane-spanning permease","Membrane, Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins and ABC transporter membrane-spanning permeases. Residues 1-249 are 64% similar to conserved hypothetical protein of Streptococcus pyogenes (gi15675926). Residues 1-250 are 57% similar to ABC transporter membrane-spanning permease of Streptococcus pneumoniae (gi15904065).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2149 (2e-87).","

InterPro
IPR003339
Family

Cobalt transport protein
PF02361	$\"[12-236]T$	CbiQ

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[145-187]T$	ABC_transporter
PF00005	$\"[33-221]T$	ABC_tran
PS00211	$\"[146-160]T$	ABC_TRANSPORTER_1
PS50893	$\"[3-245]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[32-244]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-235]T$	G3DSA:3.40.50.300
PTHR19222	$\"[3-247]T$	PTHR19222
PTHR19222:SF22	$\"[3-247]T$	PTHR19222:SF22
SSF52540	$\"[3-235]T$	SSF52540

","BeTs to 9 clades of COG1122COG name: ABC-type cobalt transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1122 is AMTK--VC-Brh--GP-l---Number of proteins in this genome belonging to this COG is 3","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 1.7e-33. IPB001140A 22-68 IPB001140B 143-181 IPB001140C 198-227","Residues 132-227 are 36% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 189-277 are 55% similar to a (ATP-BINDING PROTEOME ABC COMPLETE) protein domain (PD414231) which is seen in Q9CIS8_LACLA.Residues 89-213 are 34% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in YN26_MYCTU.Residues 23-71 are 63% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CIS8_LACLA.Residues 145-185 are 82% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in P70970_BACSU.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:45:10 2002","Wed Oct 23 15:00:47 2002","Wed Oct 23 15:00:47 2002","Mon Apr 15 16:14:52 2002","Mon Dec 24 12:41:22 2001","Mon Dec 24 12:41:22 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1949 is paralogously related (blast p-value < 1e-3) to SMu1950, SMu0517, SMu0731, SMu0218, SMu0418, SMu1762, SMu0884, SMu1288, SMu0786, SMu1380, SMu1757, SMu0916, SMu1920, SMu1003, SMu0235, SMu1246, SMu1231, SMu0849, SMu1210, SMu1079, SMu1037, SMu1428, SMu1518, SMu1001, SMu0971, SMu1064, SMu0390, SMu1068, SMu1023, SMu0805, SMu0907, SMu1036, SMu0234, SMu1751, SMu0824, SMu0950, SMu0216, SMu0374, SMu1649, SMu0335, SMu0836, SMu0594, SMu1517, SMu0976, SMu0986, SMu0476, SMu1410, SMu0944, SMu1545, SMu0164, SMu0596, SMu0825, SMu1093, SMu0258, SMu0987, SMu1710, SMu1316, SMu0666, SMu0752, SMu0475, SMu1959, SMu1065, SMu1811, SMu0224, SMu1050, SMu1724, SMu0837, SMu0024, SMu1306, SMu0823, SMu1686, SMu0729, and SMu1202, all with ATP-binding capabilities.","Mon Apr 15 16:14:52 2002","Mon Dec 24 12:41:22 2001","pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 123 3e-029pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 103 2e-023","SMU.2149c","","Residues 33 to 221 (E-value = 7.1e-60) place SMu1949 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Dec 24 12:41:22 2001","24380477","","","","Tue Oct 29 14:45:10 2002","","1","","","SMU.2149c","499" "SMu1950","2012800","2011958","843","ATGACAGATAAAATAATTGAGTTAAAAAATGTTACTTTTCGCTATGATGAAAATCAGGAAAAACCAACCTTAAATAATATTTCGTTTCACGTGAAACATGGAGAATGGTTATCAATTATTGGCCATAATGGTAGTGGTAAATCAACAACAGTACGCTTAATTGACGGACTCTTAGAAGCTGAATCAGGACAAATTTTGATAGAAGGTCACAAACTATCAGAGGACAATGTTTGGGATATTCGCCATAAAATTAGTATGGTTTTTCAAAATCCTGACAATCAATTTGTTGGGGCAACTGTAGAAGATGATATTGCTTTTGGTCTTGAAAATAAAGGAATTCCTTTAAAAGAGATGAGAGAACGCGTTGTAGAAGCCTTGAATCTTGTTGATATGTCTGATTTCAAAACACGAGAACCAGCTAGATTATCAGGGGGTCAAAAGCAAAGGGTGGCTATTGCGGGTGCAGTGGCTATGCGTCCCAGCATTATCATTTTAGATGAGGCCACTAGTATGTTAGATCCAGAAGGTCGTTTAGAGTTAATTGGAACGATTCAAAAAATTCGTGAACAATATGGTATGACAGTCATTTCAATTACACATGATTTGGATGAGGTAACACTTAGTGATCGTGTTTTGGTGATGAAAAACGGACAAATTGAATCTAGCTCAAGTCCAAGAGAGCTCTTTTCGCGAGGAGATGAACTTTTAGATCTAGGGTTAGACATCCCTTTTACCTCAACTATTATAAAGGCATTGCGACAAATTGGCTTTACATTTGATAATCGTTATTTACTAGAAAAGGAACTGGAAGATAAGTTATGGGCATTAATCTCCAAGAAGTAA","5.00","-9.53","31561","MTDKIIELKNVTFRYDENQEKPTLNNISFHVKHGEWLSIIGHNGSGKSTTVRLIDGLLEAESGQILIEGHKLSEDNVWDIRHKISMVFQNPDNQFVGATVEDDIAFGLENKGIPLKEMRERVVEALNLVDMSDFKTREPARLSGGQKQRVAIAGAVAMRPSIIILDEATSMLDPEGRLELIGTIQKIREQYGMTVISITHDLDEVTLSDRVLVMKNGQIESSSSPRELFSRGDELLDLGLDIPFTSTIIKALRQIGFTFDNRYLLEKELEDKLWALISKK","2011976","For other components see SMu1949 (NBD2) and SMu1948 (MSD1).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Many matches is gapped BLAST to ABC transporters. Residues 5-279 are 72% similar to ABC transporter of Streptococcus pyogenes (gi|15675928). Residues 3-276 are 50% similar to ABC transporter of Bacillus subtilis (gi|7445713).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2151 (1e-115).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[142-184]T$	ABC_transporter
PF00005	$\"[34-217]T$	ABC_tran
PS00211	$\"[142-156]T$	ABC_TRANSPORTER_1
PS50893	$\"[6-241]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[33-218]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-231]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-254]T$	PTHR19222
PTHR19222:SF22	$\"[6-254]T$	PTHR19222:SF22
SSF52540	$\"[5-233]T$	SSF52540

","BeTs to 7 clades of COG1122COG name: ABC-type cobalt transport system, ATPase componentFunctional Class: PThe phylogenetic pattern of COG1122 is AMTK--VC-Brh--GP-l---Number of proteins in this genome belonging to this COG is 3","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 9.9e-44. IPB001140A 23-69 IPB001140B 139-177 IPB001140C 194-223","Residues 125-218 are 31% similar to a (ATP-BINDING PROTEOME COMPLETE 230AA) protein domain (PD169303) which is seen in Q9WW89_LACLC.Residues 84-137 are 44% similar to a (ATP-BINDING SUBUNIT ABC TRANSPORTER) protein domain (PD266720) which is seen in Q9KXJ6_STRCO.Residues 227-279 are 58% similar to a (ATP-BINDING ABC TRANSPORT TRANSPORTER) protein domain (PD168118) which is seen in O87533_STRPY.Residues 31-225 are 26% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 186-225 are 57% similar to a (ATP-BINDING TRANSPORT PROTEOME COMPLETE) protein domain (PD359629) which is seen in Q9CIS9_LACLA.Residues 133-230 are 34% similar to a (ABC-BINDING PROTEOME RELATED OLIGOPEPTIDE) protein domain (PD077779) which is seen in Q9HIQ1_THEAC.Residues 123-219 are 31% similar to a (PROTEOME COMPLETE ATP-BINDING ABC) protein domain (PD033004) which is seen in Q9V0X7_PYRAB.Residues 192-273 are 36% similar to a (ATP-BINDING PROTEOME ABC COMPLETE) protein domain (PD414231) which is seen in Q9Z9J3_BACHD.Residues 185-225 are 73% similar to a (ATP-BINDING TRANSPORT COMPLETE PROTEOME ABC TRANSPORTER) protein domain (PD000079) which is seen in O87533_STRPY.Residues 85-212 are 35% similar to a (ATP-BINDING TRANSPORTER ABC ABC-TYPE) protein domain (PD027424) which is seen in Q9CCF9_MYCLE.Residues 15-235 are 26% similar to a (ATP-BINDING TRANSPORT COMPLETE MJ0121) protein domain (PD039360) which is seen in Y121_METJA.Residues 80-137 are 44% similar to a (PROTEOME COMPLETE YKOD) protein domain (PD002399) which is seen in O34362_BACSU.Residues 81-135 are 43% similar to a (TRANSPORT COBALT ATP-BINDING INNER) protein domain (PD388461) which is seen in CBIO_SALTY.Residues 24-69 are 78% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in O87533_STRPY.Residues 142-184 are 90% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in O87533_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:43:29 2002","Wed Oct 23 15:00:22 2002","Wed Oct 23 15:00:22 2002","Mon Apr 15 16:15:21 2002","Mon Dec 24 12:21:27 2001","Mon Dec 24 12:21:27 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1950 is paralogously related (blast p-value < 1e-3) to SMu1949, SMu0884, SMu1757, SMu0971, SMu1762, SMu0517, SMu0849, SMu0731, SMu0235, SMu0805, SMu0418, SMu0218, SMu1428, SMu1920, SMu1380, SMu1246, SMu1231, SMu1288, SMu1003, SMu1210, SMu0594, SMu0907, SMu1064, SMu0836, SMu0234, SMu0786, SMu0390, SMu0596, SMu0825, SMu0824, SMu0216, SMu1079, SMu1036, SMu0476, SMu1518, SMu0950, SMu0475, SMu1068, SMu0916, SMu1037, SMu0986, SMu1001, SMu1751, SMu0258, SMu1710, SMu1545, SMu0374, SMu1316, SMu0987, SMu1649, SMu1517, SMu1410, SMu1023, SMu1065, SMu0164, SMu0335, SMu0944, SMu0837, SMu0976, SMu1811, SMu0024, SMu1724, SMu0752, SMu1093, SMu0666, SMu0224, SMu1050, SMu0823, SMu1306, SMu1959, SMu0729, and SMu1686, all with ATP-binding capabilities.","Mon Apr 15 16:15:21 2002","Mon Dec 24 12:21:27 2001","pdb|1G29|1 Chain 1, Malk >gi|12084695|pdb|1G29|2 Chain 2, Malk 139 5e-034pdb|1B0U|A Chain A, Atp-Binding Subunit Of The Histidine Permea... 109 5e-025","SMU.2150c","","Residues 34 to 217 (E-value = 5.2e-61) place SMu1950 in the ABC_tran family which is described as ABC transporter (PF00005)","Mon Dec 24 12:21:27 2001","24380478","","","","Tue Oct 29 14:43:29 2002","","1","","","SMU.2150c","500" "SMu1951","2013346","2012804","543","ATGGCTAAGAAGGAAAATATCCCTAATTTATTAACGTTAATCAGAATTTTATTAATTCCAGTCTTCTTGCTTTTAACTTCTGTGACTAGTAGTGTCACTTGGCATATTATTGCAGCCATTATTTTTGCTGTGGCAAGTTTAACTGACTATTTGGATGGTTACTTAGCACGTAAGTGGAAAGTTGTTACTAATTTTGGTAAATTCGCAGATCCGCTTGCTGATAAAATGTTAGTCATGAGTGCTTTTATCATACTTGTTGGTCTTAACTTAGCGCCAGCTTGGATTTCTGCTATCATTATTTGTCGTGAATTAGCTGTAACAGGATTACGTTTACTTTTAGTTGAAACAGGTGGTGAAGTTTTGGCTGCTGCTATGCCAGGAAAAATTAAAACAGCTACTCAAATGTTTTCAATTATCTTATTGCTTTGCCATTTTGAATTTGTAGGAACTATTCTGCTTTACATAGCTCTCTTCTTTACGCTTTATTCAGGTTATGATTACTTCAAAGGAGCTGGCTTTCTTTTTAAGGATACTTTTAAATAA","9.70","4.37","19902","MAKKENIPNLLTLIRILLIPVFLLLTSVTSSVTWHIIAAIIFAVASLTDYLDGYLARKWKVVTNFGKFADPLADKMLVMSAFIILVGLNLAPAWISAIIICRELAVTGLRLLLVETGGEVLAAAMPGKIKTATQMFSIILLLCHFEFVGTILLYIALFFTLYSGYDYFKGAGFLFKDTFK","2012822","From GenBank (gi:7404422): In Bacillus subtilis, this protein catalyzes the committed step to the synthesis of the acidic phospholipids. It catalyzes the reaction: CDP-diacylglycerol + glycerol-3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate. It is an integral membrane protein that belongs to the CDP-alcohol phosphatidyltransferase class-I family.","CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase","Membrane, Cytoplasm","Many matches in gapped BLAST to phosphatidylglycerophosphate synthase. Residues 1-180 are 81% similar to phosphatidylglycerophosphate synthase (PgsA) of Streptococcus pyogenes (gi15675929). Residues 6-168 are 50% similar to PgsA of Bacillus subtilis (gi2127166).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2152 (9e-88).","

InterPro
IPR000462
Family

CDP-alcohol phosphatidyltransferase
PF01066	$\"[39-170]T$	CDP-OH_P_transf
PS00379	$\"[52-74]T$	CDP_ALCOHOL_P_TRANSF

InterPro
IPR004570
Family

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
TIGR00560	$\"[5-178]T$	pgsA

noIPR
unintegrated

unintegrated
PIRSF000847	$\"[5-179]T$	Phos_ph_gly_syn
PTHR14269	$\"[6-169]T$	PTHR14269
PTHR14269:SF3	$\"[6-169]T$	PTHR14269:SF3

","BeTs to 15 clades of COG0558COG name: Phosphatidylglycerophosphate synthaseFunctional Class: IThe phylogenetic pattern of COG0558 is A-tKYQvcEbRhujgpOLINxNumber of proteins in this genome belonging to this COG is 1","***** IPB000462 (CDP-alcohol phosphatidyltransferase) with a combined E-value of 2.4e-16. IPB000462 49-85","Residues 36-158 are 50% similar to a (TRANSFERASE COMPLETE PROTEOME SYNTHASE) protein domain (PD001399) which is seen in Q9KAA4_BACHD.Residues 1-48 are 66% similar to a (TRANSFERASE PHOSPHOTIDYLGLYCEROPHOSPHATE) protein domain (PD379029) which is seen in O87532_STRPY.Residues 107-168 are 49% similar to a (SYNTHASE PHOSPHATIDYLGLYCEROPHOSPHATE) protein domain (PD344421) which is seen in PGSA_BACSU.Residues 49-106 are 87% similar to a (SYNTHASE TRANSFERASE) protein domain (PD406953) which is seen in O87532_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Apr 15 16:15:37 2002","Mon Aug 21 17:09:22 2006","Mon Aug 21 17:09:22 2006","Mon Apr 15 16:15:37 2002","Mon Dec 24 12:04:37 2001","Mon Dec 24 12:04:37 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1951 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Dec 24 12:10:02 2001","","No significant hits to the NCBI PDB database.","SMU.2151c","","Residues 39 to 170 (E-value = 1.4e-38) place SMu1951 in the CDP-OH_P_transf family which is described as CDP-alcohol phosphatidyltransferase (PF01066)","Mon Dec 24 12:04:37 2001","","","","Kontinen,V.P. and Tokuda,H. Overexpression of phosphatidylglycerophosphate synthase restores protein translocation in a secG deletion mutant of Escherichia coli at low temperature. FEBS Lett. 364 (2), 157-160 (1995) PubMed: 7750561","","Mon Dec 24 12:04:37 2001","1","","","SMU.2151c","741" "SMu1952","2014335","2013358","978","ATGAACAAGATAGGTGATACTCTACGTGATGCTCGTATTGAAAAAAAATTGAGTTTTGATGATGTTGTAGATAAAACTGGAATTGCTCCTCACTATATACTGGCAATGGAGTTAGATCAACTTAAATTATTACCAGAAGGCAAAACAAATGAGTATTTAGAAAAATATGCTCATGCTGTTGGCTTAGATCCGGTTTCTATTATTCATGGTTATCGCAATCAGGAAATGAGCGATGAACTTATCCTACCTTCTTCTGCAGAATTGGCTGCTTCTTCAGATAGCAATATAGAAAAGAAAAATGAAGGAAAATCAATTGAAGAACCTCAAGAGTTAGCTATTGATAGTTTGGATGTTACTCAAAATATTACAGAAGAGACTCCCCAAATAGAAGATTTTAAGGTTGAATCAGAGGAGGCAAGTAAAAAAATAGAAAAAATACCATCTCGACTTAGTAAATATGATTATGATGAAGAACCGAAAAAGAAATTTCCATGGGCTTTAATTCTGCTAATTTTACTTGCTTTAACTATTATCAGTTATGTTGGATATGTGGTTTATAATCAGCTGCAAACTGATTCAAATAAGACTGAATTAAGTACCTCTACGAAAAAATCTAAGGATACTAAAAATGATGCCAATTCAACGACACAAAGTCAGACCAGCATAACAACAGACTTTGCTGATGGTGGAAATAATATCACCTTAAGTAATACTAATGGAAAAGTAGAGGTTACCTTTACTTTGACAGGGGATGAGGAAAGTTGGGTTTCAGCAACTAACACTACTGATGGAGAATCTGGAACAACTCTAACAGCAACAGATAAAACTTATACTGTTACTTTAGCAGAAGGTTCAACAACATCTATGCTGACAGTCGGATCACCTAGCGGTGTTGAAATTACGATCAATGGTCAAAAGGTGGATACTACAAACCTTGTTAATGCTGGTTTGACTAATATTAATTTGACAGTCCAATAA","4.40","-21.24","35550","MNKIGDTLRDARIEKKLSFDDVVDKTGIAPHYILAMELDQLKLLPEGKTNEYLEKYAHAVGLDPVSIIHGYRNQEMSDELILPSSAELAASSDSNIEKKNEGKSIEEPQELAIDSLDVTQNITEETPQIEDFKVESEEASKKIEKIPSRLSKYDYDEEPKKKFPWALILLILLALTIISYVGYVVYNQLQTDSNKTELSTSTKKSKDTKNDANSTTQSQTSITTDFADGGNNITLSNTNGKVEVTFTLTGDEESWVSATNTTDGESGTTLTATDKTYTVTLAEGSTTSMLTVGSPSGVEITINGQKVDTTNLVNAGLTNINLTVQ","2013376","","conserved hypothetical protein","Extracellular, Membrane","Few partial very weak matches in gapped BLAST to conserved hypothetical proteins. Residues 4-74 are 46% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675930). Residues 234-324 are 30% similar to conserved hypothetical protein of Lactococcus lactis (gi|15673953).SMu1952 has no significant similarity (BLAST p-value < 1e-3) to Streptococcus agalactiae","

InterPro
IPR010982
Domain

Lambda repressor-like, DNA-binding
SSF47413	$\"[1-69]T$	Lambda_like_DNA

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 234-324 are 39% similar to a (YUED PROTEOME COMPLETE) protein domain (PD414910) which is seen in O87531_STRPY.Residues 4-74 are 46% similar to a (DOMAIN OF UNKNO N) protein domain (PD213447) which is seen in O87531_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:30:54 2002","Mon Dec 24 11:54:39 2001","Mon Dec 24 11:54:39 2001","Mon Dec 24 11:54:39 2001","","Mon Dec 24 11:54:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1952 is paralogously related (blast p-value < 1e-3) to SMu0631, a predicted hypothetical protein and SMu0635, a predicted conserved hypothetical protein.","Mon Apr 15 16:16:52 2002","","No significant hits to the NCBI PDB database.","SMU.2152c","","No significant hits to the Pfam 11.0 database","Mon Dec 24 11:54:39 2001","24380480","","","","","","1","","","SMU.2152c","" "SMu1953","2015700","2014408","1293","TTGGCAGCAACAAGATTAAAGAGACGAAAATTTCCAACTATTAATGAGGAATTTTACTATAATCAACTAGAAAATGGTATGACTGTTTTTTTGATACCTAAAGAATCATTTAAGGAAACACTTGCTGTAATGAGCAGTCGCTTTGGATCAATTGACACAAACTTTACAGTTAATGGTAAAAAGAAATCTTATTTAGCAGGTATTGCTCACCTTTTAGAACATCAGTTATTTGAAATGAATAAACAAAAAGATGCTGCTTATGAATTTACAAAATTAGGTGCAGAAAGCAATGCTTACACAACTTTTGATAAAACAATTTATTACTTTTCAACAGCTGATAATATCAAGAAAAATTTAGATTTATTACAGGAGTTTACCAGTCAAATAAACTTTACAGATATGTCAATTGAAAAAGAAAAAAAAATCATAACTCAAGAATTTAATATGTATCAAGATGATTCTGATGATTATCTTTACCAAGTTATTTTATCTAAACTTTATCCTCAAACCTCTTTAGCAGAAGATATTACTGGGAATAGAGATAGTATTGATAAATTAACAAAAAATAACTTAGAGGAAAATTTTCATTATTTTTATCAACCTGAAAATTTAACTCTTTTAGTGGCAGGAGATTTTGATGTTAAAAGGGTTTATAAAGATATTGTTACTACTCAAAGGCAGTTACCAGACAGGCCCAAATTTGAAATCAAACGTTCTCCTTTAAAGTTACTACCAATAACTCCAACGAGTTCAATGCAAATGGATATTTCTATTTCAAAGTTAGCAGTAGGCTTTCGCTTTAATTTTATTAAGAAAAAACGGAAATCTTTGATAAAGGAAAGATTACTTTTAAAGCTCTTTTTTTTACTTTTGTTTGGTTGGACATCAGAGCACTATCAGCAATGGTATGAAGATAGAAAAATTGATGATTCTTTTGAATTAAAAATTGAAGTGTCAACTTCTTATCAATTTGTTGTCATTTTGCTTGACACTAAAGAGCCAATAGCAATGTCTAACAAGATTGGGCAAACAATTAAGAAGTTTAAGACAGATACCAATCTTTCTGCCTCACATTTACAAACAGTAAAAAAAGAGCTATATGGTGATTTTATTCGGAGTTTAGATTCACTTGAGGCTCTTTCTAGTCAATTTATAGATAATTTATGGGGAGAAGAAACTTATTTTGATTTTCCTACTGTTTTGCAAAATATAGAAATAAAAGATGTATTGGAATTTGGAGAAAAAATAACAAAGGAAATGCAGCTAACCGATTTTACATTATTTCCAAAATAA","6.40","-1.75","50405","MAATRLKRRKFPTINEEFYYNQLENGMTVFLIPKESFKETLAVMSSRFGSIDTNFTVNGKKKSYLAGIAHLLEHQLFEMNKQKDAAYEFTKLGAESNAYTTFDKTIYYFSTADNIKKNLDLLQEFTSQINFTDMSIEKEKKIITQEFNMYQDDSDDYLYQVILSKLYPQTSLAEDITGNRDSIDKLTKNNLEENFHYFYQPENLTLLVAGDFDVKRVYKDIVTTQRQLPDRPKFEIKRSPLKLLPITPTSSMQMDISISKLAVGFRFNFIKKKRKSLIKERLLLKLFFLLLFGWTSEHYQQWYEDRKIDDSFELKIEVSTSYQFVVILLDTKEPIAMSNKIGQTIKKFKTDTNLSASHLQTVKKELYGDFIRSLDSLEALSSQFIDNLWGEETYFDFPTVLQNIEIKDVLEFGEKITKEMQLTDFTLFPK","2014426","","peptidase, M16 family","Cytoplasm, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins and proteases. Residues 4-430 are 44% similar to unknown of Streptococcus pyogenes (gi3426365). Residues 7-429 are 40% similar to peptidase, M16 family of Streptococcus pneumoniae (gi15902028).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2153 (6e-95).","

InterPro
IPR007863
Domain

Peptidase M16, C-terminal
PF05193	$\"[185-366]T$	Peptidase_M16_C

InterPro
IPR011765
Domain

Peptidase M16, N-terminal
PF00675	$\"[63-158]T$	Peptidase_M16

noIPR
unintegrated

unintegrated
G3DSA:3.30.830.10	$\"[5-236]T$	no description
PTHR11851	$\"[67-430]T$	METALLOPROTEASE
PTHR11851:SF30	$\"[67-430]T$	INSULINASE - RELATED

","BeTs to 10 clades of COG0612COG name: Predicted Zn-dependent peptidasesFunctional Class: RThe phylogenetic pattern of COG0612 is ----YQvCEBrhUJ--o---xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 166-214 are 53% similar to a (PROTEASE METALLOPROTEASE ZINC COMPLETE PROTEOME) protein domain (PD129062) which is seen in O87530_STRPY.Residues 23-163 are 50% similar to a (PROTEASE PROTEOME COMPLETE ZINC) protein domain (PD111666) which is seen in O87530_STRPY.Residues 166-242 are 31% similar to a (PROTEOME COMPLETE PROTEASE ZINC) protein domain (PD117961) which is seen in Q9CE73_LACLA.Residues 67-149 are 35% similar to a (PROTEASE METALLOPROTEASE ZINC HYDROLASE MITOCHONDRIAL) protein domain (PD000718) which is seen in Q40983_PEA.Residues 293-414 are 49% similar to a (PROTEOME COMPLETE PROTEASE BH2392) protein domain (PD111692) which is seen in O87530_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Thu Aug 31 17:42:08 2006","Thu Aug 31 17:42:08 2006","Thu Aug 31 17:42:08 2006","Tue Oct 8 13:30:18 2002","","Mon Dec 24 11:43:55 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1953 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:30:18 2002","Thu Aug 31 17:42:08 2006","pdb1BGYA Chain A, Cytochrome Bc1 Complex From Bovine >gi4139... 70 4e-013pdb1QCRA Chain A, Crystal Structure Of Bovine Mitochondrial C... 70 4e-013pdb1BCCA Chain A, Cytochrome Bc1 Complex From Chicken >gi582... 67 5e-012","SMU.2153c","","Residues 28 to 180 (E-value = 4.5e-06) place SMu1953 in the Peptidase_M16 family which is described as Insulinase (Peptidase family M16) (PF00675)Residues 185 to 366 (E-value = 1.2e-09) place SMu1953 in the Peptidase_M16_C family which is described as Peptidase M16 inactive domain (PF05193)","Thu Aug 31 17:42:08 2006","24380481","","","","","","1","","","SMU.2153c","608" "SMu1954","2016949","2015702","1248","ATGAAATTAGCCCAAGATGTGCAGTTACACTTGCTTAAAACAAGTCAATTTAAGACGAATCACATTACCTTTCGTTTTTCTGGTGAATTAGATAGTAAAACACTTGCTCGTCGTGTTTTAGTTGCTCAGATGTTGGCAACTGCTAATAATGTTTATCCAACATCTCAAACTTTTAGAGAAAAGTTGGCCAATTTATATGGTGCTCAGTTTTCGACCTGTATATCAAAAAAAGGAAAGGTTCATATTGTTGATATAGACATTTCTTTTGTATCTGATAAATTTATTTTGGAAGGAAAGTCAATCTTAGGAGAAATTATCCATTTCTTAAGAGCGGCACTTTTTAAACCTCTCATTTCAGTAGAGCATTATCAAAGTAAAAGTTTTGATCTTGAAAAAGAAAATTTAATGAGATATTTACAATCTGACAAAGAGGATTCTTTTTATTATAGTCACTTAGAGTTACAAAAACTCTTTTTTAAAGATGAAGTTCTAAAATATTCAAAATATGCTACTGCAGAGTTAGTAAGTGCTGAAAATTCCTATACAACGTACCAAGAATTTCAAAAAATGTTAAAAGAAGATCAGATTGATATCTTTGTTTTGGGGGATTTCGATGAATATCAAGTTTTACAATCTATTGAAGAATTTCCCTTAGAAGATCGCCAAAAAACATTGATCTTTGATTACCAACAAGAATATTCGAAGATTGTTCAGGAAAAAGTTGAACAGCAAGAAAACCAACAGTCTCTTTTACAACTAGGCTATCATTTTCCTATAGCTTATGGAGATCATAATTACTATGCCCTACTTGTTTTTAATGGTCTTTTAGGAGTTTTTCCTCATTCTAAATTATTTACTGAAGTTCGAGAAAAAAGAAGATTGGCTTATAATATTGGAAGTTATTTTGATATTTACACAGGTTTACTTCAAGTTTACACAGGTCTTGACAGTAACAAAAGACAACAGGTATTTCAGTTGATAACAAAGCAATTCAATGATTTAAAATTAGGCCGGTTTTCAAGCCATTTATTAGCTCAAACAAAAAAGATGTTAATAAACAATATGCAATTATTTGAGGACAACCCCAAAAATAGAATTGAAATGCATTATAATCATTGTGTTTTTGGAGATAAATGTTTAGAGCTGAAAGAATGGATTGACAGAATTGACAAAGTTAGTAAAGACGATATTGTCAAAGCAGCTAATCTCATTAAGTTACAGTCTATTTATTTTTTAGAAGGAGAGTAG","6.80","-1.22","48732","MKLAQDVQLHLLKTSQFKTNHITFRFSGELDSKTLARRVLVAQMLATANNVYPTSQTFREKLANLYGAQFSTCISKKGKVHIVDIDISFVSDKFILEGKSILGEIIHFLRAALFKPLISVEHYQSKSFDLEKENLMRYLQSDKEDSFYYSHLELQKLFFKDEVLKYSKYATAELVSAENSYTTYQEFQKMLKEDQIDIFVLGDFDEYQVLQSIEEFPLEDRQKTLIFDYQQEYSKIVQEKVEQQENQQSLLQLGYHFPIAYGDHNYYALLVFNGLLGVFPHSKLFTEVREKRRLAYNIGSYFDIYTGLLQVYTGLDSNKRQQVFQLITKQFNDLKLGRFSSHLLAQTKKMLINNMQLFEDNPKNRIEMHYNHCVFGDKCLELKEWIDRIDKVSKDDIVKAANLIKLQSIYFLEGE","2015720","","peptidase, M16 family","Cytoplasm, Extracellular","Several matches in gapped BLAST to conserved hypothetical proteins and proteases. Residues 1-414 are 52% similar to conserved hypothetical protein of Streptococcus pyogenes (gi15675932). Residues 9-414 are 38% similar to protease of Lactococcus lactis (gi15673955).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2154 (1e-125).","

InterPro
IPR007863
Domain

Peptidase M16, C-terminal
PF05193	$\"[187-351]T$	Peptidase_M16_C

noIPR
unintegrated

unintegrated
G3DSA:3.30.830.10	$\"[237-405]T$	G3DSA:3.30.830.10
PTHR11851	$\"[40-402]T$	PTHR11851
PTHR11851:SF61	$\"[40-402]T$	PTHR11851:SF61
SSF63411	$\"[2-217]T$ $\"[241-402]T$	SSF63411

","BeTs to 7 clades of COG0612COG name: Predicted Zn-dependent peptidasesFunctional Class: RThe phylogenetic pattern of COG0612 is ----YQvCEBrhUJ--o---xNumber of proteins in this genome belonging to this COG is 2","No significant hits to the Blocks database.","Residues 30-124 are 60% similar to a (PROTEOME COMPLETE PROTEASE BH2393) protein domain (PD072040) which is seen in O87529_STRPY.Residues 255-414 are 50% similar to a (PROTEASE PROTEOME COMPLETE PROCESSING ZINC MITOCHONDRIAL) protein domain (PD001445) which is seen in O87529_STRPY.Residues 132-231 are 55% similar to a (PROTEOME COMPLETE PROTEASE) protein domain (PD209861) which is seen in O87529_STRPY.Residues 1-29 are 79% similar to a (DOMAIN OF UNKNO N) protein domain (PD173496) which is seen in O87529_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 20 15:22:42 2006","Wed Sep 20 15:22:42 2006","Wed Sep 20 15:22:42 2006","Tue Oct 8 13:28:15 2002","","Mon Dec 24 11:39:09 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1954 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:28:15 2002","","No significant hits to the NCBI PDB database.","SMU.2154c","","Residues 186 to 351 (E-value = 1.8e-27) place SMu1954 in the Peptidase_M16_C family which is described as Peptidase M16 inactive domain (PF05193)","Mon Dec 24 11:39:09 2001","24380482","","","","","","1","","","SMU.2154c","501" "SMu1955","2017028","2017393","366","ATGGAATATAAACTCTTTAATGACTACATTACATTACAAGCTCTTTTAAAAAATTTGGGAGTTATTCCAAGTGGAGGAGCCATAAAATCTTATTTGGCCAATACGGAGGTCTTATTTAATGGTCAACCTGAAACGCGTCGTGGCAAAAAACTTCGTCTAGGAGACCAAATTAGTATTCCAAATTTAGATATCATTATTACTATTATTGAACCTTCTTCAAAAGAAAGGGAAGACTACTTAAAAAATCTGGCTGAAAAAGAACAAGTGGTAGCTTTTGTCAAAAAATTCAACAAAAAGAAGAAACAACAAAGCAAACAGAAAACAAGTACCAAACCTAAAAAAACTATTAAATTTCCTGGCACTTAA","10.70","11.99","13752","MEYKLFNDYITLQALLKNLGVIPSGGAIKSYLANTEVLFNGQPETRRGKKLRLGDQISIPNLDIIITIIEPSSKEREDYLKNLAEKEQVVAFVKKFNKKKKQQSKQKTSTKPKKTIKFPGT","2017405","","conserved hypothetical protein","Cytoplasm, Periplasm","Few matches in gapped BLAST to conserved hypothetical proteins. Residues 1-93 are 62% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675936). Residues 2-93 are 39% similar to conserved hypothetical protein of Lactococcus lactis (gi|15673956).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2155 (1e-25).","

InterPro
IPR002942
Domain

RNA-binding S4
PS50889	$\"[10-84]T$	S4

InterPro
IPR014330
Family

S4 region, YaaA
TIGR02988	$\"[2-61]T$	YaaA_near_RecF

noIPR
unintegrated

unintegrated
G3DSA:3.10.290.10	$\"[7-68]T$	G3DSA:3.10.290.10
SSF55174	$\"[1-68]T$	SSF55174

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 8-64 are 50% similar to a (PROTEOME COMPLETE YUFA YYAA) protein domain (PD027758) which is seen in Q48692_BBBBB.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:26:50 2002","Mon Dec 24 11:29:55 2001","Mon Dec 24 11:29:55 2001","Mon Dec 24 11:29:55 2001","","Mon Dec 24 11:29:55 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1955 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 13:26:50 2002","","No significant hits to the NCBI PDB database.","SMU.2155","","No significant hits to the Pfam 11.0 database","Mon Dec 24 11:29:55 2001","24380483","","","","","","1","","","SMU.2155","992" "SMu1956","2017396","2018487","1092","ATGTGGATAGAAAAAATTAATTTAAAACATTATCGCAATTATACAGCCATTGAATCTGAATTTTCCCAAAGTCTTAATGTTTTTGTGGGACAAAATGCTCAAGGAAAAACCAATTTCCTAGAGGCTATTTATTTTTTATCTTTAACCCGCAGTCATCGAACACGATCTGACAAAGAACTTATTCAATTTGGTCAAAAAGAATTAAATGTTTCTGGCCTTCTTAATCGTGTCAATGGCAAAATTCCTCTGGAAATCAACTTATCTAATAAAGGCCGAACAACAAAAATAAATTATCTCAAACAACCTAAACTTTCAGACTATATTGGAACAATGACTGTTGTTCTCTTTGCTCCAGAAGATCTTCAACTAATAAAAGGCTCCCCAAGTCTCAGAAGAAAGTTTATTGACATTGATTTAGGACAAATCAAGCCTATTTACTTATCTGATTTATCAAATTATAATCATGTTCTTAAACAACGAAACGCCTATTTAAAATCAGAGAAGAAGGTTGATACTGATTTTCTTTTCGTTCTAGATGAACAATTGGTAGATTATGGTAGTAAGGTTATTGAGCATCGCCTTGATTTTATTCAAAATTTAACTAAAGAAGCTGATAAATATCATTTCTCTATTTCAAATCAACAGGAACATTTAAAAATTTCCTACCTTTCTTCTGTTAAATTTGATCATAAAAAAAATATTCGTGATAACTTTTTAAACCTGCTACAAAAAAATCGGCAGGGTGATATTTTCAAAAAGAACACCAGTGTTGGTCCACACCGCGATGATTTAGCCTTTTTCATCAATCAAATGAACGCTAGCTTTGGTAGTCAAGGACAACATCGCAGCCTTATTTTATCTTTAAAGCTGGCTGAGATTGAACTTACAAAAACAGTCACTGGGGATTATCCTATTCTCTTGTTAGATGATGTCATGAGTGAACTTGATAATTATAGACAAATCAAACTTTTAGAAGGCATCAAAGATAATGTTCAGACCTTTATAACAACAACTAGCCTTGAACATCTTCAACAACTCCCTAAGAAACTAAAGTTATTTACTATCAACCAAGGAAAAGTGCTATCAGAATAG","10.10","11.42","41990","MWIEKINLKHYRNYTAIESEFSQSLNVFVGQNAQGKTNFLEAIYFLSLTRSHRTRSDKELIQFGQKELNVSGLLNRVNGKIPLEINLSNKGRTTKINYLKQPKLSDYIGTMTVVLFAPEDLQLIKGSPSLRRKFIDIDLGQIKPIYLSDLSNYNHVLKQRNAYLKSEKKVDTDFLFVLDEQLVDYGSKVIEHRLDFIQNLTKEADKYHFSISNQQEHLKISYLSSVKFDHKKNIRDNFLNLLQKNRQGDIFKKNTSVGPHRDDLAFFINQMNASFGSQGQHRSLILSLKLAEIELTKTVTGDYPILLLDDVMSELDNYRQIKLLEGIKDNVQTFITTTSLEHLQQLPKKLKLFTINQGKVLSE","2018499","For other 'rec' genes see SMu0021 (recO);SMu0532 (recN); SMu0545 (recR),(recM);SMu1892 (recA); SMu0425 (recU) ; SMu1669 (recG); SMu1705 (recD) and SMu1339 (recJ).From GenBank (gi:14195686): The RecF protein in S. pyogenes is involved in DNA metabolism. It is required for DNA replication and normal SOS inducibility. RecF (cytoplasmic) binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.","recombination protein F (DNA replication and repair ATPase)","Cytoplasm","Numerous strong matches in gapped BLAST to recombination protein F. Residues 1-360 are 69% similar to recF of Streptococcus pyogenes (gi1075773). Residues 1-361 are 43% similar to DNA repair and genetic recombination protein recF of Bacillus subtilis (gi16077072).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2156 (1e-148).","

InterPro
IPR001238
Family

RecF protein
TIGR00611	$\"[1-360]T$	recf
PS00617	$\"[116-136]T$	RECF_1
PS00618	$\"[305-323]T$	RECF_2

InterPro
IPR003395
Domain

SMC protein, N-terminal
PF02463	$\"[2-361]T$	SMC_N

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-344]T$	G3DSA:3.40.50.300
SSF52540	$\"[1-343]T$	SSF52540

","BeTs to 7 clades of COG1195COG name: ATPases involved in DNA repairFunctional Class: LThe phylogenetic pattern of COG1195 is -------cebrh-----li-xNumber of proteins in this genome belonging to this COG is 1","***** IPB001238 (RecF protein) with a combined E-value of 3.1e-67. IPB001238A 8-53 IPB001238B 115-136 IPB001238C 153-165 IPB001238D 242-264 IPB001238E 304-320","Residues 53-166 are 74% similar to a (DNA REPAIR REPLICATION ATP-BINDING) protein domain (PD003952) which is seen in RECF_STRPY.Residues 177-337 are 69% similar to a (DNA REPAIR REPLICATION DAMAGE) protein domain (PD358672) which is seen in RECF_STRPY.Residues 104-170 are 35% similar to a (DNA REPLICATION REPAIR ATP-BINDING) protein domain (PD385942) which is seen in RECF_XYLFA.Residues 1-45 are 68% similar to a (DNA REPAIR REPLICATION ATP-BINDING) protein domain (PD000596) which is seen in RECF_STRPY.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Sep 20 15:30:12 2006","Wed Sep 20 15:30:12 2006","Wed Sep 20 15:30:12 2006","Wed Apr 3 09:13:02 2002","Mon Dec 24 11:25:28 2001","Mon Dec 24 11:25:28 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1956 is paralogously related (blast p-value < 1e-3) to SMu0987, a predicted ABC transporter, MutT.","Mon Apr 15 16:18:00 2002","","No significant hits to the NCBI PDB database.","SMU.2156","","No significant hits to the Pfam 11.0 database","Mon Dec 24 11:25:28 2001","24380484","","DeAngelis,P.L., Yang,N. and Weigel,P.H. Molecular cloning of the gene encoding RecF, a DNA repair enzyme, from Streptococcus pyogenes. Gene 156 (1), 89-91 (1995) PubMed: 7737521","","Mon Dec 24 11:25:28 2001","","1","","","SMU.2156","502" "SMu1957","2020131","2018650","1482","ATGTCAAATTGGGACACCAAATTTTTGAAAAAAGGTTATACTTTTGATGATGTATTACTTATTCCGGCTGAAAGCCATGTTCTTCCAAACGAAGTCAGTATGCAAACAAAATTAGCGAAAAATTTGACATTGAATATTCCAATTATTACTGCAGCTATGGATACTGTTACTGATAGTAAGATGGCTATTGCTATTGCGCGTGCAGGCGGTCTTGGTGTTGTTCATAAAAATATGTCAATCAAAGAACAAGCTGAAGAAGTTCGAAAAGTAAAACGCTCAGAAAATGGTGTTATTATTGATCCTTTCTTTTTGACACCAGAGCATAAGGTGTCTGAAGCCGAAGAATTGATGCAGCGTTATCGTATTAGTGGTGTTCCGGTCGTTGAAACCCTTGATAATCGTAAGTTAATTGGAATTATTACCAATCGTGATATGCGTTTTATTTCTGACTATGAAACCCCTATTTCAGAACATATGACTAGTGAAAAGTTGGTCACAGCTCCTGTGGGAACAGATCTTGAAACAGCTGAACGTATCTTACATGAGCACCGTATTGAAAAATTACCTTTGATTGATGAAAAAGGTCGTTTATCTGGTCTCATTACTATCAAAGATATCGAAAAAGTTATTGAATTTCCAAATGCAGCAAAAGATGAATTTGGCCGCCTTCTAGTTGCTGGTGCGGTTGGTGTCACATCAGATACTTTTGAACGTGCTGAAGCTCTCTTTGAAGCTGGAGCAGATGCTATCGTTATTGATACCGCTCATGGACATTCTGCAGGTGTACTTCGTAAGATTGCTGAAATTAGAGCTCATTTTCCAGATCGTACCTTGATTGCTGGCAATATTGCGACTGCTGAAGGAGCACGTGCCCTTTATGAAGCAGGTGTTGATGTCGTTAAGGTGGGTATTGGACCTGGTTCAATTTGTACAACACGTGTAGTTGCTGGTGTTGGTGTTCCTCAAATTACAGCTATTTATGATGCAGCCAGTATTGCGCGTGAATATGGACGAACGATCATTGCTGATGGTGGTATCAAGTATTCAGGTGATATTGTTAAAGCCCTTGCTGCAGGTGGAAATGCTGTGATGCTTGGTTCAATGTTCGCTGGTACTGATGAAGCTCCAGGTGAAACAGAAATCTTTCAAGGTCGTAAATTTAAAACTTATCGTGGTATGGGATCAATTGCAGCTATGAAGAAAGGATCAAGCGATCGCTACTTCCAAGGGTCTGTTAATGAAGCTAATAAACTTGTTCCAGAAGGTATTGAAGGGCGTGTAGCTTATAAGGGAGCTGCAGCTGATATTGTTTTTCAAATGCTTGGTGGCATTCGCTCTGGTATGGGTTATGTTGGTGCAGCTAATCTTAAAGAACTTCATGAAAATGCTCAATTTATTGAAATGTCAGGTGCTGGTTTGATTGAAAGTCACCCTCATGATGTTCAAATAACTAATGAAGCTCCAAATTATTCTGTACAATGA","5.90","-8.11","53084","MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVSMQTKLAKNLTLNIPIITAAMDTVTDSKMAIAIARAGGLGVVHKNMSIKEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRYRISGVPVVETLDNRKLIGIITNRDMRFISDYETPISEHMTSEKLVTAPVGTDLETAERILHEHRIEKLPLIDEKGRLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPDRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVVAGVGVPQITAIYDAASIAREYGRTIIADGGIKYSGDIVKALAAGGNAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVPEGIEGRVAYKGAAADIVFQMLGGIRSGMGYVGAANLKELHENAQFIEMSGAGLIESHPHDVQITNEAPNYSVQ","2018668","For other 'gua' genes see SMu0974 (guaA) and SMu0962 (guaA).From GenBank (gi:1708474): In Streptococcus Pyogenes, this enzyme catalyzes the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH. This is the first reaction unique to GMP biosynthesis. It is a homotetramer protein similar to other eukaryotic and prokaryotic IMP dehydrogenases and to GMP reductases.","inosine-5'- monophosphate dehydrogenase","Cytoplasm, Membrane","Numerous strong matches in gapped BLAST to inosine monophosphate dehydrogenases. Residues 1-492 are 93% similar to inosine monophosphate dehydrogenase of Streptococcus pyogenes (gi15675939). Residues 4-492 are 67% similar to IMP dehydrogenase of Bacillus subtilis (gi16077077).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2159 (0.0).","

InterPro
IPR000644
Domain

Cystathionine-beta-synthase
PF00571	$\"[95-211]T$	CBS
SM00116	$\"[100-150]T$ $\"[163-211]T$	CBS

InterPro
IPR001093
Family

IMP dehydrogenase/GMP reductase
PTHR11911:SF6	$\"[5-480]T$	IMP_DH_GMPRtase
PF00478	$\"[11-479]T$	IMPDH
PS00487	$\"[300-312]T$	IMP_DH_GMP_RED

InterPro
IPR005990
Family

IMP dehydrogenase
TIGR01302	$\"[12-461]T$	IMP_dehydrog

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[2-492]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
PIRSF000130	$\"[4-493]T$	IMPDH
PTHR11911	$\"[5-480]T$	PTHR11911
SSF51412	$\"[1-489]T$	SSF51412

","BeTs to 13 clades of COG0516COG name: IMP dehydrogenase/GMP reductaseFunctional Class: FThe phylogenetic pattern of COG0516 is -MTKYQVcEBRHUJ--O--n-Number of proteins in this genome belonging to this COG is 1","***** IPB001093 (IMP dehydrogenase / GMP reductase) with a combined E-value of 7e-105. IPB001093A 13-22 IPB001093B 39-81 IPB001093C 295-326 IPB001093D 339-378 IPB001093E 401-410 IPB001093F 439-450 IPB001093B 220-262 IPB001093F 418-429","Residues 269-366 are 66% similar to a (DEHYDROGENASE OXIDASE OXIDOREDUCTASE BIOSYNTHESIS FMN) protein domain (PD000662) which is seen in Q9X168_THEMA.Residues 278-323 are 95% similar to a (DEHYDROGENASE BIOSYNTHESIS OXIDOREDUCTASE GMP) protein domain (PD304134) which is seen in IMDH_STRPY.Residues 370-481 are 93% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD001792) which is seen in IMDH_STRPY.Residues 324-490 are 28% similar to a (DEHYDROGENASE BIOSYNTHESIS DOMAIN) protein domain (PD044384) which is seen in IMDH_TRIFO.Residues 324-368 are 93% similar to a (DEHYDROGENASE BIOSYNTHESIS OXIDOREDUCTASE GMP IMP) protein domain (PD394519) which is seen in IMDH_STRPY.Residues 10-93 are 91% similar to a (DEHYDROGENASE BIOSYNTHESIS INOSINE-5'-MONOPHOSPHATE) protein domain (PD002050) which is seen in IMDH_STRPY.Residues 164-210 are 92% similar to a (COMPLETE PROTEOME DEHYDROGENASE DOMAIN) protein domain (PD000251) which is seen in IMDH_STRPY.Residues 370-461 are 39% similar to a (DEHYDROGENASE BIOSYNTHESIS OXIDOREDUCTASE GMP DOMAIN CBS) protein domain (PD004298) which is seen in IMH2_ARATH.Residues 100-160 are 42% similar to a (COMPLETE PROTEOME DEHYDROGENASE) protein domain (PD403287) which is seen in IMDH_METJA.Residues 211-263 are 96% similar to a (DEHYDROGENASE BIOSYNTHESIS INOSINE-5'-MONOPHOSPHATE IMP) protein domain (PD329452) which is seen in IMDH_STRPY.Residues 159-208 are 64% similar to a (DEHYDROGENASE BIOSYNTHESIS) protein domain (PD338945) which is seen in Q9RT87_DEIRA.Residues 324-377 are 45% similar to a (NAD DEHYDROGENASE OXIDOREDUCTASE ML0388) protein domain (PD289563) which is seen in Q9L0I6_STRCO.Residues 324-369 are 58% similar to a (PROTEOME COMPLETE INOSINE DEHYDROGENASE) protein domain (PD377953) which is seen in Q9HQU4_HALN1.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Aug 29 09:38:35 2006","Tue Aug 29 09:38:35 2006","Tue Aug 29 09:36:56 2006","Mon Apr 8 09:08:28 2002","Mon Dec 24 11:06:21 2001","Tue Aug 29 09:38:35 2006","yes","Fri Feb 20 15:41:32 MST 1998","SMu1957 is paralogously related (blast p-value < 1e-3) to SMu1218, a predicted enoyl-acyl carrier protein(ACP) reductase; dioxygenase related to 2-nitropropane dioxygenase; SMu1516,a predicted acetoin utilization protein, acetoin dehydrogenase and SMu1588, a predicted trans-2-enoyl-ACP reductase II.","Mon Apr 15 16:20:09 2002","Tue Aug 29 09:36:56 2006","pdb1ZFJA Chain A, Inosine Monophosphate Dehydrogenase (Impdh;... 885 0.0pdb1B3OB Chain B, Ternary Complex Of Human Type-Ii Inosine Mo... 320 3e-088pdb1EEPB Chain B, 2.4 A Resolution Crystal Structure Of Borre... 314 1e-086","SMU.2157c","","Residues 11 to 479 (E-value = 5.3e-205) place SMu1957 in the IMPDH family which is described as IMP dehydrogenase / GMP reductase domain (PF00478)Residues 95 to 150 (E-value = 7.6e-11) place SMu1957 in the CBS family which is described as CBS domain (PF00571)Residues 158 to 211 (E-value = 1.8e-12) place SMu1957 in the CBS family which is described as CBS domain (PF00571)","Tue Aug 29 09:36:56 2006","","","Ashbaugh,C.D. and Wessels,M.R. Cloning, sequence analysis and expression of the group A streptococcal guaB gene encoding inosine monophosphate dehydrogenase. Gene 165 (1), 57-60 (1995) PubMed: 7489916Zhang,R., Evans,G., Rotella,F.J., Westbrook,E.M., Beno,D., Huberman,E., Joachimiak,A. and Collart,F.R. Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase. Biochemistry 38 (15), 4691-4700 (1999) PubMed: 10200156","","Tue Aug 29 09:38:35 2006","","1","","","SMU.2157c","209" "SMu1958","2021310","2020288","1023","ATGTCAAAACCTATTATTTTAACAGGAGATCGACCAACAGGAAAATTACATTTGGGTCATTATGTTGGTAGTCTTAAAAATCGTGTCCTTTTACAAAATGAAAATAAATATGAAATGTTTGTTTTTTTAGCAGATCAACAAGCTCTCACAGATCATGCTAAAGAATCAGAAATTATTAAAGATTCTATTGCAAATGTTGCTCTTGATTATTTGTCAGTAGGTCTTGACCCTGAAAAGGTCACTATTTTTATCCAAAGTCAAATTCCGGAATTAGCTGAATTGACCATGTATTATATGAATTTAGTATCATTGGCTCGTTTGGAACGCAATCCAACTGTTAAAACTGAAATTGCTCAAAAAGGATTTGGCGAATCTATTCCAACAGGATTTTTAGTTTATCCTATTTCTCAAGCGGCTGATATTACAGCTTTTAAAGCAAATTATGTACCTGTTGGCAATGACCAAAAACCCATGATTGAACAAACGCGTGAAATTGTGCGTAGCTTTAATCATACTTATAAAACAAATTGTTTAGTAGAACCAGAAGGTATTTATCCTAAAAATGAGGCAGCTGGTCGTTTACCAGGTTTAGATGGTAATGCAAAGATGTCGAAATCACTTGGTAATGGTATTTTTCTTTCTGATGACGCTGATACCGTTCGTAAGAAAGTGATGAGCATGTACACAGATCCAAATCATATTCGTGTTGAAGATCCAGGCCAAATTGAAGGAAATATGGTTTTTCACTATCTTGATATTTTTGGACGTAAAGAAGACCAAACGGATATTGCAGCTATGAAAGAACATTATCAAAGTGGTGGACTTGGAGATGTTAAGACCAAACATTATCTTTTAGATATTCTTGAACGAGAATTAACACCAATACGTAGACGCCGTCTGGAGTATGAAAAAAATATGGATCAAGTTTTAGATATTTTAAAAAAAGGTAGTGAAACAGCACGTGAAACAGCTTCAGAAACCTTAAGTGGAGTTAAAAGGGCTATGGGAATTAATTATTTTTAG","6.30","-3.09","38313","MSKPIILTGDRPTGKLHLGHYVGSLKNRVLLQNENKYEMFVFLADQQALTDHAKESEIIKDSIANVALDYLSVGLDPEKVTIFIQSQIPELAELTMYYMNLVSLARLERNPTVKTEIAQKGFGESIPTGFLVYPISQAADITAFKANYVPVGNDQKPMIEQTREIVRSFNHTYKTNCLVEPEGIYPKNEAAGRLPGLDGNAKMSKSLGNGIFLSDDADTVRKKVMSMYTDPNHIRVEDPGQIEGNMVFHYLDIFGRKEDQTDIAAMKEHYQSGGLGDVKTKHYLLDILERELTPIRRRRLEYEKNMDQVLDILKKGSETARETASETLSGVKRAMGINYF","2020306","From GenBank (gi:2501069): In Clostridium longisporum, this enzyme catalyzes the reaction: ATP + L-tryptophan + tRNA(TRP) = AMP + pyrophosphate + L-tryptophanyl-tRNA (TRP). It is a cytoplasmic homodimer that belongs to the class-I aminoacyl-tRNA synthetase family.","tryptophanyl-tRNA synthetase","Cytoplasm","Numerous strong matches in gapped BLAST to tryptophanyl-tRNA synthetases. Residues 1-340 are 86% similar to putative tryptophanyl-tRNA synthetase of Streptococcus pyogenes (gi|15675940). Residues 1-340 are 79% similar to tryptophanyl-tRNA synthetase of Lactococcus lactis (gi|15672048).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2168 (1e-163).","

InterPro
IPR001412
Family

Aminoacyl-tRNA synthetase, class I
PS00178	$\"[12-21]T$	AA_TRNA_LIGASE_I

InterPro
IPR002305
Domain

Aminoacyl-tRNA synthetase, class Ib
PF00579	$\"[3-293]T$	tRNA-synt_1b

InterPro
IPR002306
Family

Tryptophanyl-tRNA synthetase, class Ib
PR01039	$\"[16-32]T$ $\"[69-88]T$ $\"[147-168]T$ $\"[202-212]T$	TRNASYNTHTRP
PTHR10055	$\"[9-340]T$	Trp_tRNA-synt_1b
TIGR00233	$\"[2-337]T$	trpS

InterPro
IPR014729
Domain

Rossmann-like alpha/beta/alpha sandwich fold
G3DSA:3.40.50.620	$\"[3-224]T$	Rossmann-like_a/b/a_fold

noIPR
unintegrated

unintegrated
G3DSA:1.10.730.10	$\"[194-227]T$	G3DSA:1.10.730.10
SSF52374	$\"[3-339]T$	SSF52374

","BeTs to 15 clades of COG0180COG name: Tryptophanyl-tRNA synthetaseFunctional Class: JThe phylogenetic pattern of COG0180 is amtkYqvcebrhujgpolinxNumber of proteins in this genome belonging to this COG is 1","***** IPB001412 (Aminoacyl-transfer RNA synthetases class-I) with a combined E-value of 4.9e-08. IPB001412A 10-20 IPB001412B 199-209","Residues 247-340 are 63% similar to a (SYNTHETASE LIGASE TRYPTOPHANYL-TRNA) protein domain (PD333617) which is seen in Q9CJD1_LACLA.Residues 1-130 are 83% similar to a (SYNTHETASE LIGASE TRYPTOPHANYL-TRNA) protein domain (PD129039) which is seen in Q9CJD1_LACLA.Residues 131-243 are 85% similar to a (SYNTHETASE LIGASE TRYPTOPHANYL-TRNA) protein domain (PD247980) which is seen in Q9CJD1_LACLA.Residues 131-245 are 69% similar to a (SYNTHETASE LIGASE AMINOACYL-TRNA) protein domain (PD001451) which is seen in SYW_CLOLO.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 13:44:12 2002","Mon Dec 24 10:56:08 2001","Mon Dec 24 10:56:08 2001","Wed Oct 9 13:44:12 2002","Mon Dec 24 10:56:08 2001","Mon Dec 24 10:56:08 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1958 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Wed Oct 9 13:44:12 2002","Mon Dec 24 10:56:08 2001","pdb|1D2R|A Chain A, 2.9 A Crystal Structure Of Ligand-Free Tryp... 146 5e-036pdb|1D2R|A Chain A, 2.9 A Crystal Structure Of Ligand-Free Tryp... 463 2e-131","SMU.2158c","","Residues 3 to 293 (E-value = 6.3e-88) place SMu1958 in the tRNA-synt_1b family which is described as tRNA synthetases class I (W and Y) (PF00579)","Mon Dec 24 10:56:08 2001","24380486","","","","","","1","","","SMU.2158c","504" "SMu1959","2021743","2023362","1620","TTGCTAACTGTATCAGATATTTCGCTGCGTTTCAGTGATCGTAAACTTTTTGATAATGTCAATATTAAATTTACAGCGGGAAATACTTATGGGTTGATTGGTGCTAATGGTGCTGGAAAATCAACTTTCTTAAAAATCCTATCAGGTGATATTGAACCTACCACAGGCCATGTTTCTCTTGGTCCAGAGGAACGCTTATCTATTTTACGTCAAAATCATTTTGATTACGAAGAAGAACGCGCTATTGATGTTGTTATTATGGGCAATCAAGATCTCTATAACATCATGAAAGAAAAAGATGCTATCTATATGAAACCTGATTTTTCAGATGAGGATGGTGTTCGCGCCGCTGAACTTGAAGGTCAGTTTGTGGAATTAAATGGCTGGGAAGCTGAAAGTGAAGCTTCTCAGCTCTTGCAAAATTTGAATATTCCTGAAGAACTTCACTATCAAAACATGAGTGAGCTCACTAACGGTGATAAAGTTAAAGTGTTACTTGCTAAAGCACTTTTTGGTAAACCAGATGTTCTTTTACTAGATGAACCTACCAATGGTTTAGATATCCAATCTATCAATTGGTTAGAGGATTTCTTAATAGACTTTGAAAATACTGTTATTGTAGTCTCTCACGACCGCCATTTTCTCAATAAAGTCTGCACTCATATGGCTGATCTAGATTTTGGAAAAATTAAACTCTATGTGGGTAATTATGATTTTTGGAAAGAATCTTCTGAACTAGCAGCAAAACTTCAAGCTGACCGTAATGCTAAAGCAGAAGAAAAAATCAAAGAATTACAAGAATTTGTTGCCCGCTTTTCAGCCAATGCTTCTAAATCAAAACAAGCAACTTCTCGTAAAAAAATGCTTGATAAAATTGAGTTAGAAGAAATTGTACCTTCAAGCCGTAAGTATCCCTTTATTAAGTTTCAAGCGGAACGTGAAATTGGAAATGATCTTTTATCAGTAGAAAACCTTTCAGTTAAAATTGATGGTGAAAGCATTCTTGACAATATCAGTTTTACTTTAAATCCTGGAGATAAAACTGCTATTATTGCCCAAAATGATATTCAGTCAACAGCTCTTATTCGTGCACTTATGGGAGATATTGACTATGAAGGTACCATTAAATGGGGTGTTACAACAAGTCAATCCTATCTTCCTAAAGACAATACAAATGATTTTGCGAGTGGAGAATCTATTCTTGAATGGATCCGTCAGTTTGCAAACAAAGAAGATGATGATAATACTTTTCTTCGTGGGTTCTTGGGTCGTATGCTTTTTTCTGGTGATGAAGTTAACAAGTCTGTCAGTGTCCTATCAGGTGGCGAAAAAGTGCGTGTGATGTTAGCTAAACTTATGCTCCTCAAGTCCAATGTACTGGTACTCGACGATCCAACTAATCACTTAGACTTAGAGTCTATCTCAAGCTTAAATGATGGGCTTAAAGATTTCAAAGAATCTATTATTTTTGCTAGCCATGATCATGAATTTATCCAAACATTAGCAAATCATATTTTGGTTATCTCTAAAAATGGTGTCATTGATCGTATTGATGAGACTTATGATGAATTTCTTGAAAATGAAGAAGTTCAGGCTAAAGTAGCACAACTCTGGCAATAA","4.50","-32.56","60759","MLTVSDISLRFSDRKLFDNVNIKFTAGNTYGLIGANGAGKSTFLKILSGDIEPTTGHVSLGPEERLSILRQNHFDYEEERAIDVVIMGNQDLYNIMKEKDAIYMKPDFSDEDGVRAAELEGQFVELNGWEAESEASQLLQNLNIPEELHYQNMSELTNGDKVKVLLAKALFGKPDVLLLDEPTNGLDIQSINWLEDFLIDFENTVIVVSHDRHFLNKVCTHMADLDFGKIKLYVGNYDFWKESSELAAKLQADRNAKAEEKIKELQEFVARFSANASKSKQATSRKKMLDKIELEEIVPSSRKYPFIKFQAEREIGNDLLSVENLSVKIDGESILDNISFTLNPGDKTAIIAQNDIQSTALIRALMGDIDYEGTIKWGVTTSQSYLPKDNTNDFASGESILEWIRQFANKEDDDNTFLRGFLGRMLFSGDEVNKSVSVLSGGEKVRVMLAKLMLLKSNVLVLDDPTNHLDLESISSLNDGLKDFKESIIFASHDHEFIQTLANHILVISKNGVIDRIDETYDEFLENEEVQAKVAQLWQ","2023374","For other components see SMu1960 (MSD1 and MSD2).","ABC transporter, ATP-binding protein","Cytoplasm, Membrane","Many strong matches in gapped BLAST to ABC transporter, ATP-binding proteins. Residues 1-539 are 90% similar to ABC transporter ATP-binding protein of Streptococcus pneumoniae (gi15902034). Residues 1-538 are 64% similar to ABC transporter (ATP-binding protein) of Bacillus subtilis (gi16078507).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2171 (0.0).","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[155-198]T$ $\"[439-477]T$	Q99XH2_STRPY_Q99XH2;
PF00005	$\"[27-228]T$ $\"[361-512]T$	ABC_tran
PS50893	$\"[2-252]T$ $\"[320-537]T$	ABC_TRANSPORTER_2
PS00211	$\"[439-453]?$	ABC_TRANSPORTER_1

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[26-228]T$ $\"[344-512]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-284]T$ $\"[315-539]T$	no description
PTHR19211	$\"[126-529]T$	ATP-BINDING TRANSPORT PROTEIN-RELATED
PTHR19211:SF11	$\"[126-529]T$	ABC TRANSPORTER (ATP-BINDING PROTEIN)

","BeTs to 10 clades of COG0488COG name: ATPase components of ABC transporters with duplicated ATPase domainsFunctional Class: RThe phylogenetic pattern of COG0488 is ----Y--CEBRHuj--olinxNumber of proteins in this genome belonging to this COG is 4","***** IPB001140 (ABC transporter transmembrane region) with a combined E-value of 5.9e-22. IPB001140A 16-62 IPB001140B 436-474 IPB001140A 334-380 IPB001140B 153-191","Residues 334-380 are 60% similar to a (PROTEOME BINDING COMPLETE ABC) protein domain (PD381440) which is seen in Q9CJC5_LACLA.Residues 433-481 are 53% similar to a (PROTEOME BINDING ATP-BINDING COMPLETE) protein domain (PD335182) which is seen in Q9X7B1_MYCLE.Residues 204-523 are 21% similar to a (ATP-BINDING ABC TRANSPORTER) protein domain (PD068705) which is seen in Q9ZC01_STRCO.Residues 422-499 are 33% similar to a (ATP-BINDING) protein domain (PD397028) which is seen in Q53712_STRAT.Residues 381-438 are 66% similar to a (ATP-BINDING COMPLETE PROTEOME ABC) protein domain (PD052788) which is seen in Q9CJC5_LACLA.Residues 137-198 are 53% similar to a (ATP-BINDING RESISTANCE PLASMID COMPLETE) protein domain (PD019698) which is seen in Q9ZKZ3_HELPJ.Residues 439-483 are 53% similar to a (PROTEOME COMPLETE ABC TRANSPORTER) protein domain (PD188894) which is seen in Q9Z9F8_CHLPN.Residues 418-477 are 41% similar to a (ABC TRANSPORTER ABC-TRANSPORTER) protein domain (PD330281) which is seen in Q9F901_STRPN.Residues 253-331 are 51% similar to a (ATP-BINDING PROTEOME TRANSPORTER COMPLETE) protein domain (PD331218) which is seen in O51684_BORBU.Residues 249-332 are 80% similar to a (ATP-BINDING TRANSPORTER ABC PROTEOME) protein domain (PD004492) which is seen in Q9CJC5_LACLA.Residues 65-120 are 55% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD015427) which is seen in O51684_BORBU.Residues 439-482 are 50% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD250554) which is seen in Q9KBA3_BACHD.Residues 484-529 are 73% similar to a (ATP-BINDING ABC TRANSPORTER PROTEOME COMPLETE REPEAT) protein domain (PD000796) which is seen in Q9CJC5_LACLA.Residues 153-199 are 57% similar to a (PROTEOME TRANSPORTER COMPLETE ABC) protein domain (PD189333) which is seen in Q9KH28_CAMJE.Residues 112-156 are 51% similar to a (ATP-BINDING PROTEOME COMPLETE ABC) protein domain (PD379910) which is seen in O83810_TREPA.Residues 60-120 are 68% similar to a (ATP-BINDING COMPLETE PROTEOME TRANSPORTER) protein domain (PD389196) which is seen in O31716_BACSU.Residues 17-58 are 83% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000005) which is seen in Q9CJC5_LACLA.Residues 439-477 are 84% similar to a (ATP-BINDING TRANSPORT ABC TRANSPORTER COMPLETE PROTEOME) protein domain (PD000006) which is seen in Q9CJC5_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 29 14:47:07 2002","Fri Dec 21 19:40:45 2001","Tue Aug 29 09:48:33 2006","Mon Apr 15 16:21:48 2002","Fri Dec 21 19:40:45 2001","Fri Dec 21 19:40:45 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1959 is paralogously related (blast p-value < 1e-3) to SMu1306, SMu0823, SMu0729, SMu0418, SMu1757, SMu0907, SMu0849, SMu1762, SMu1410, SMu1949, SMu0390, SMu0218, SMu1518, SMu0944, SMu1001, SMu1079, SMu0731, SMu1093, SMu0517, SMu1920, SMu0164, SMu0976, SMu1288, SMu0596, SMu0786, SMu1023, SMu1037, SMu1003, SMu0950, SMu0335, SMu0258, SMu1751, SMu1517, SMu0235, SMu1710, SMu0216, SMu1811, SMu1068, SMu0916, SMu0884, SMu1649, SMu0666, SMu1545, SMu1724, SMu1210, SMu1036, SMu0971, SMu1380, SMu0594, SMu0374, SMu1950, SMu0224, SMu0752, SMu0234, SMu0476, SMu0836, SMu1246, SMu1231, SMu1065, SMu0475, SMu1064, SMu1316, SMu0825, SMu0837, SMu0987, SMu1202, SMu0824, SMu0024, SMu1428, SMu0805, SMu1050, and SMu0986,all with ATP-binding capabilities.","Mon Apr 15 16:21:48 2002","Tue Aug 29 09:48:33 2006","pdb1B0UA Chain A, Atp-Binding Subunit Of The Histidine Permea... 77 4e-015","SMU.2159","","Residues 27 to 228 (E-value = 4.5e-45) place SMu1959 in the ABC_tran family which is described as ABC transporter (PF00005)Residues 359 to 511 (E-value = 3.6e-11) place SMu1959 in the ABC_tran family which is described as ABC transporter (PF00005)","Tue Aug 29 09:48:33 2006","24380487","","","","","","1","","","SMU.2159","210" "SMu1960","2023402","2025975","2574","ATGAAAATTTTTATAAAAAAACACCAACAAAGTATTCTTTACTATAGTCTTAGTTTTCTGCTACCAAGTTTTATAATGTTTCTCGTTCTATTCTCCAAAAATATTTATTGGGGGAGTAGCACAACTATTTTAGCTAGTGATGGTTTTCATCAATATGTGATTTTTGATGCTCTTTTTCGTAATATTCTCCATGGAACGGATAGTTTGTTTTACTCTTTTAAGGCTGGGCTTGGTTTTAATATTTTTGCTCTGACAAGTTATTACTTGGGAAGTTTTTTAACACCTTTTACTTACTTTTTTAATGTAAAAAATATGGCAGATGCTTTTTATCTCTTCACTTTAATCAAATTTGGTCTAATAGGTTTATCTGCTTTTTACAGTCTTGGGCAAATTTATACTAAAATCTCTAAATCACTCGTTTTGATGCTGTCAACATCTTATGCTTTAATGAGCTTTACTAGCAGTCAGTTAGAATTAAACAATTGGTTAGATGTTTTTATCCTGCTACCACTTATTATGCTTGGTTTACAGCGTTTAGTAGAAAAAAGGGGGATTTTTCTTTATTTTCTAACTCTTACTTGTTTATTTATTCAAAATTACTATTTTGGTTTCATGACAGCTATTTTCTTAACTCTTTGGTTTTTTACGCAAGTCTCGTGGGATATTAGAAACAGAATGAAACGATTAAGTGATTTTGTGCTCGTATCAATCTTTGCAACGCTGACAAGTGCTTTTATGCTGCTTCCAACATTTCTTGATTTAAAGAGCCATGGTGAAGTATTAACAGAACAAATTAGTCTATTTTCATCAGACATTTGGTATTTCGATTTTTTTGCTAAAAGTCTTCTTGGTAGTTATGATACGACAAAATATGGCTCTATTCCAACGATTTATATCGGTTTACTTCCCTTGATTTTTGCCATTACTTTTTTCTTTGTTAAATCTATAAAATGGCAAGTTAAAGTAGCTTATTTTCTTTTATTGGCTATTATTATTGCAAGTTTTATCTTTCAACCACTTGATTTATTTTGGCAAGGAATGCATTCACCTAATATGTTTTTGCATCGTTATTCTTGGGCTTTCTCCTTAGTTATTGTCATAATGGCAGCTGAAACGTTAACTCGGATAAAGGATATAAAATTGAAAAATTTTTATCCAGCCTTTACCTTCTTGGGAGTAGGACTTTTAGCAACTTTTTTATTCAAGGACTATTATAATTATCTGACACAAGTTAATTTTATATTAACAACTATCTTTTTAGTTAGTTATTTTATTATTCTTTTTACTTTTTTTAATCAATTAGTTTCTTATAAAGTTATTATTTCCTTTACACTTATCTTTACAAGTTTTGAAATAGCTTTAAATACTTTTTATCAAATTGAAGGTATTCAAACTGACTGGAATTTCCCTTCAAGAGAGGTTTATGAAGATAATGTAAAGGAAATTGACAACTATGTTAAGAAAACTAAAAAAGATAACTTAGAATTTTTTCGAACAGAAAAACAAATTCCCCAAACTTACAATGATGGTATGAAATTTAATTATAATAGCATTTCTCAGTTCTCATCTGTCAAAAATAACTTATCAGCACAATTATTGAATTCTCTAGGCTACTATTCACAAGGAAATCATTCTACCATTAGTTATCCTAATAATACTATTTTGATGGATAGTCTTTTTTCAATTAAATACAATATTAATAATCAAAATCCTCATAAATTTGGATTCCATTTAAAACAGAAAAACAATAAGCTGCAACTTTACAAAAACTTCTATTCTCTTCCTTTAGCACTTATGTCAAATCATATTTACAAAGATGTCAAGTTTGACTCTTATCCCCTTGATAATCAACAAAAATTTGTTAATGAATTGACAGATCTAAATCTTACACTTTTCAAAGAAATCCCTATTATTTCAAGTGTCGGAATGCAAGTTTTAGATAATCGTGTTACTATTAATGGTTCAAAAGGAAATAAGGCACAAGTTTACTATACTGTAAAGTGTCCTGCAAATAGTCAACTTTATATCAGCCTTCCTAACTTGACAGTTAATAATAAAGACGAAAATGTCTTTATAACAACTAACAAGCACACAAGTTCTTATATCATAGACGAAAGTTATTATCTTTTTAATTTAGGAAATTATAAAAAAACTCAAACATTAATATTTAAGCTTAGTTTTCCAAAAAATAAAACGGTTAGTTATGATTTACCACATATTTATGCTCTCGATTTAACTGCCTATCAAAAAAGTATAAAGCAATTAAAAAGTCAAACTGTTAAAACAACAACTAAGAAAAATAAAATTTTTACTACCTATGTTGCCAAAAAGAGAACTTCCTTGATTTACACTTTACCATATGATAAAGGTTGGTTTGCTAAACAAAATGGAAAAGCAATTAAAATATCTAAAGCACAAAATGGACTAATGAAAATTGATGTTTCTAAAGGTAGTGGGAAGATTATAATGACTTTTGTGCCCCAAGGACTATATCAAGGAATTCTTCTTACCTGTCTAGGTATCTTTCTCTTTGTATTTTACCAACTTTATTACAAAAAATTTAATTTAAAATAA","10.40","37.75","99692","MKIFIKKHQQSILYYSLSFLLPSFIMFLVLFSKNIYWGSSTTILASDGFHQYVIFDALFRNILHGTDSLFYSFKAGLGFNIFALTSYYLGSFLTPFTYFFNVKNMADAFYLFTLIKFGLIGLSAFYSLGQIYTKISKSLVLMLSTSYALMSFTSSQLELNNWLDVFILLPLIMLGLQRLVEKRGIFLYFLTLTCLFIQNYYFGFMTAIFLTLWFFTQVSWDIRNRMKRLSDFVLVSIFATLTSAFMLLPTFLDLKSHGEVLTEQISLFSSDIWYFDFFAKSLLGSYDTTKYGSIPTIYIGLLPLIFAITFFFVKSIKWQVKVAYFLLLAIIIASFIFQPLDLFWQGMHSPNMFLHRYSWAFSLVIVIMAAETLTRIKDIKLKNFYPAFTFLGVGLLATFLFKDYYNYLTQVNFILTTIFLVSYFIILFTFFNQLVSYKVIISFTLIFTSFEIALNTFYQIEGIQTDWNFPSREVYEDNVKEIDNYVKKTKKDNLEFFRTEKQIPQTYNDGMKFNYNSISQFSSVKNNLSAQLLNSLGYYSQGNHSTISYPNNTILMDSLFSIKYNINNQNPHKFGFHLKQKNNKLQLYKNFYSLPLALMSNHIYKDVKFDSYPLDNQQKFVNELTDLNLTLFKEIPIISSVGMQVLDNRVTINGSKGNKAQVYYTVKCPANSQLYISLPNLTVNNKDENVFITTNKHTSSYIIDESYYLFNLGNYKKTQTLIFKLSFPKNKTVSYDLPHIYALDLTAYQKSIKQLKSQTVKTTTKKNKIFTTYVAKKRTSLIYTLPYDKGWFAKQNGKAIKISKAQNGLMKIDVSKGSGKIIMTFVPQGLYQGILLTCLGIFLFVFYQLYYKKFNLK","2025987","For other components see SMu1959 (NBD1 and NBD2 ) and SMu1960 (MSD2).From GenBANK (gi:3043878): Tmp5 of L. lactis was identified as a fusion to a signal peptide-less form of the staphylococcal nuclease reporter which displays nuclease activity (see below).From Medline (98196737): Staphylococcus aureus secreted nuclease (Nuc), a reporter for gram-positive bacteria, devoid of its export signal (called delta(SP)Nuc) was used to create two fusions whose locations could be differentiated. Nuclease activity was shown to require an extracellular location in Lactococcus lactis. All delta(SP)Nuc fusions displaying a strong Nuc+ phenotype contained a classical or a lipoprotein-type signal peptide or single or multiple transmembrane stretches. The function of some of the predicted signals was confirmed by cell fractionation studies. The fusions analyzed included long (up to 455-amino-acid) segments of the exported proteins. Results with L. lactis show that delta(SP)Nuc is well suited to report both protein export and membrane protein topology.","possible permease, ABC transporter protein","Membrane, Cytoplasm","Few strong matches in gapped BLAST to conserved hypothetical proteins. Residues 26-857 are 43% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675943). Also strongly similar to a putative permease, ABC transporter protein. Residues 29-847 are 43% similar to putative ABC transporter, permease protein of Streptococcus pneumoniae (gi|15902035).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2172 (0.0).","

noIPR
unintegrated

unintegrated
signalp	$\"[1-32]?$	signal-peptide
tmhmm	$\"[12-31]?$ $\"[37-55]?$ $\"[70-90]?$ $\"[109-129]?$ $\"[139-159]?$ $\"[197-217]?$ $\"[232-252]?$ $\"[291-313]?$ $\"[323-343]?$ $\"[353-373]?$ $\"[383-401]?$ $\"[411-431]?$ $\"[440-458]?$ $\"[831-851]?$	transmembrane_regions

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 42-374 are 21% similar to a (MEMBRANE INTEGRAL) protein domain (PD327244) which is seen in Q9EWD3_STRCO.Residues 58-847 are 40% similar to a (PROTEOME COMPLETE YFHO YIEH) protein domain (PD148064) which is seen in Q9CHA3_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Oct 28 13:06:15 2002","Fri Dec 21 19:06:10 2001","Mon Oct 28 13:05:31 2002","Fri Dec 21 19:06:10 2001","","Fri Dec 21 19:06:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1960 is paralogously related (blast p-value < 1e-3) to SMu1873 ,a predicted hypothetical protein; SMu1875,a predicted conserved hypothetical protein (possible integral membrane protein/ABC transporter) and SMu0906, a predicted ABC transporter, permease protein;possible ferrichrome transport system.","Mon Apr 15 16:23:45 2002","","No significant hits to the NCBI PDB database.","SMU.2160","","No significant hits to the Pfam 11.0 database","Fri Dec 21 19:06:10 2001","24380488","","","Poquet,I., Ehrlich,S.D. and Gruss,A. An export-specific reporter designed for gram-positive bacteria: application to Lactococcus lactis. J. Bacteriol. 180 (7), 1904-1912 (1998) PubMed: 9537391","","Fri Dec 21 19:06:10 2001","1","","","SMU.2160","211" "SMu1961","2027429","2026767","663","ATGACAAAAGATTATCAAAATTTTGAAGGTTTAAGAGTAGCTATGCTTCTAACTTTTATGAGTGGTTTTATTGATGCTTATACATTTATTACACAAGGCGGGCGCTTTGCTAGCATGCAAACCGGAAATCTTCTGTATATGATGATGAAATTTGCAGATGGTCATTTTAAAGAAGCTTTTAGTTTTTTTATTCCGATTATTTTCTTTATTTTAGGACAATTTTTCTACTATTTTCTTAGAAAGTGGATTACACCTAAAAATTTAAGGTGGCATAAATCAAGTACTTATGTATTATTTATTTTATTATCTGTTATAGCTATTTTTAGTCCGATTTTACCCTCTATTTTTACGATTGCGGGATTAGCCTTTTTCGCTTCTATTCAACTAGCAACCTTCAAAAGAGTCAGAGGTTATCCTTATACTAATACTATGATGACTGGAAATATAAAAAATGCTGCTTATCTTTTTCTTAAGGGTAGTGTAGAAAAAAATGAGCAGATTAGAAAGCAGGCTTTTTATATTTTTATGGCTATTATTATGTTTATGATAGGCGTTTTACTATCAACTGTTATGTGCCGTTATTTAATCAAAAGTAGTTTATATTTTTTACTTTTGCCTATGTTAGCCTTAATTTATTTTTTAAATAAAGAAGAAGCCCTTTAG","10.70","12.42","25621","MTKDYQNFEGLRVAMLLTFMSGFIDAYTFITQGGRFASMQTGNLLYMMMKFADGHFKEAFSFFIPIIFFILGQFFYYFLRKWITPKNLRWHKSSTYVLFILLSVIAIFSPILPSIFTIAGLAFFASIQLATFKRVRGYPYTNTMMTGNIKNAAYLFLKGSVEKNEQIRKQAFYIFMAIIMFMIGVLLSTVMCRYLIKSSLYFLLLPMLALIYFLNKEEAL","2026785","","conserved hypothetical protein","Membrane, Cytoplasm","Few matches to conserved hypothetical proteins in gapped BLAST. Residues 3-217 are 42% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15674550). Residues 9-195 are 32% similar to unknown protein of Lactococcus lactis (gi|15674045).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG1559 (1e-43).","

InterPro
IPR010699
Family

Protein of unknown function DUF1275
PF06912	$\"[11-215]T$	DUF1275

","No hits to the COGs database.","No significant hits to the Blocks database.","Residues 9-204 are 33% similar to a (PROTEOME COMPLETE) protein domain (PD119110) which is seen in Q9CDY8_LACLA.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 13:25:55 2002","Mon Dec 24 13:26:28 2001","Fri Dec 21 18:40:54 2001","Fri Dec 21 18:40:54 2001","","Fri Dec 21 18:40:54 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1961 is paralogously related (blast p-value < 1e-3) to SMu0127, a predicted conserved hypothetical protein.","Mon Apr 15 16:24:47 2002","","No significant hits to the NCBI PDB database.","SMU.2161c","","Residues 11 to 215 (E-value = 5.6e-79) place SMu1961 in the DUF1275 family which is described as Protein of unknown function (DUF1275) (PF06912)","Fri Dec 21 18:40:54 2001","24380489","","","","","","1","","","SMU.2161c","837" "SMu1962","2028251","2027772","480","ATGAAAGTCAAATTAATCACAGTTGGTAAATTAAAGGAAAAATATCTGAAAGATGGGATTGCTGAATATTGTAAACGTCTAAAGCGTTTTACTAAATTTGAACTGGAAGAATTACCCGATGAGAAAATTCCAAATAATGCTAGTCAAGCTCAAAATACTTATATTCTTGAAAAAGAGGGTCAGCGAATTCTTAATAAGATTTCTAATCGTGAGTTTGTTATTGTTTTAGCAATAGAAGGGAAGCAATTTTCTTCTGAGAAATTTAGCCAACTTTTATCTGCTACAATGTTGAAGGGATATTCTGATTTGACCTTCGTTATTGGAGGGAGTTTAGGATTATCACAGGAAGTTAAAAAAAGAGCTTCTATATTAATGAGCTTTGGGTTATTAACTCTTCCTCATCAGTTAATGCGTCTTGTTTTTGTAGAACAAATTTATCGAGCCTTTATGATTCAAGAGGGAAGTCCTTACCATAAATAA","10.30","8.43","18252","MKVKLITVGKLKEKYLKDGIAEYCKRLKRFTKFELEELPDEKIPNNASQAQNTYILEKEGQRILNKISNREFVIVLAIEGKQFSSEKFSQLLSATMLKGYSDLTFVIGGSLGLSQEVKKRASILMSFGLLTLPHQLMRLVFVEQIYRAFMIQEGSPYHK","2027790","","conserved hypothetical protein","Cytoplasm","Several matches in gapped BLAST to conserved hypothetical proteins. Residues 1-159 are 69% similar to conserved hypothetical protein of Streptococcus pyogenes (gi|15675944). Residues 1-159 are 55% similar to conserved hypothetical protein of Bacillus subtilis (gi|16081075).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2173 (3e-59).","

InterPro
IPR003742
Family

Protein of unknown function DUF163
PF02590	$\"[1-158]T$	DUF163
TIGR00246	$\"[1-159]T$	DUF163

noIPR
unintegrated

unintegrated
G3DSA:3.40.1280.10	$\"[1-159]T$	G3DSA:3.40.1280.10
PIRSF004505	$\"[1-159]T$	MT_bac
SSF75217	$\"[1-158]T$	SSF75217

","BeTs to 4 clades of COG1576COG name: Uncharacterized ACRFunctional Class: SThe phylogenetic pattern of COG1576 is ------v-eb-huj-------Number of proteins in this genome belonging to this COG is 1","***** IPB003742 (DUF163) with a combined E-value of 1.4e-53. IPB003742A 1-44 IPB003742B 106-159","Residues 1-159 are 70% similar to a (PROTEOME COMPLETE YYDA PA4004) protein domain (PD010975) which is seen in P72565_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Tue Oct 8 11:39:51 2002","Fri Dec 21 18:37:39 2001","Fri Dec 21 18:37:39 2001","Tue Oct 8 11:39:51 2002","Fri Dec 21 18:37:39 2001","Fri Dec 21 18:37:39 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1962 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Oct 8 11:39:51 2002","","No significant hits to the NCBI PDB database.","SMU.2162c","","Residues 1 to 158 (E-value = 1.9e-84) place SMu1962 in the DUF163 family which is described as Uncharacterized ACR, COG1576 (PF02590)","Fri Dec 21 18:37:39 2001","24380490","","","","","","1","","","SMU.2162c","869" "SMu1963","2028457","2029665","1209","GTGAATAATACGAAATCTCACCCTTTTTTAAAATGGTTTATACCTTTTTTAGTTATTTTTTTAACTTTTATTTTAGGGGTCATATCAACACTTACCTTTAATTGGATAACTGGTAACAAATCGTTTTCTAACAATGGAAAAACAACTGTTAGTAATGTCATTTATGATACCAAATCTAACACTACCAAGGCTGTTAAAAATGTCAAAAATACAGTTGTATCTGTCATCAATTATCAAAAAACAGATAATAGTTATTACAATTATGACAGCGGTTCTCAAGAAAAAAATAAATCAGAGGATGGTCTAGGAGTCTACGGTGAAGGTTCTGGTGTTATCTATAAAAAAGATGGCGATAGTGCTTATTTAGTTACAAACAATCATGTCGTTAAAGATGCAGAAAAGTTAGAAATCATGATGGCTAATGGTAAAAAAGTTGTCGGTAAATTAGTAGGTTCTGATACTTATTCTGATCTGGCTGTTATTAAAATTTCTTCTAAGTATGTTACGACAGTTGCTGAATTTGCTAATTCGGATAAAATAAAAGTTGGAGAACCAGCAATCGCTATTGGTAGCCCTTTAGGCAGTGATTATGCTAATTCTGTAACAGAAGGAATTGTTTCAAGTCTCAGTCGTACAGTAACTTCACAAAATGAAAATGGCGAAACAATTTCAACTAATGCTATTCAAACAGACGCAGCTATTAACCCTGGTAATTCTGGTGGCGCTTTAATTAATATCAAAGGACAAGTTATTGGTATCAATTCAAGTAAAATTGCATCAAGTAATAACTCAAATAGTGGCGTTGCTGTTGAAGGAATGGGCTTTGCAATTCCTTCAAACGATGTTGTCTCTATTATTAATCAATTAGAAGAAAATGGTGAAGTTGTTAGACCCGCTCTTGGTATTTCAATGGCTAATCTTAGTGAAGCTTCAACAAGTGGAAGAGATACTTTAAAAATACCAAGTGATGTCACAAGCGGTATTGTTGTTCTTTCAACACAAAGTGGTATGCCAGCAGATGGGAAGCTGAAGAAATATGATGTCATTACAGAAATTGATGGGAAGAAGGTAGCGTCTATCAGCGATCTTCAAAGTATTCTTTACAAACACAAAAAGGGAGATAAAATTAAACTCACTTTCTATCGCGAAAAAGATAAACAAACAGTTGAGATCCAATTAACTAAAACAAGTCAAGATTTGAATCATTAA","9.20","2.98","43027","MNNTKSHPFLKWFIPFLVIFLTFILGVISTLTFNWITGNKSFSNNGKTTVSNVIYDTKSNTTKAVKNVKNTVVSVINYQKTDNSYYNYDSGSQEKNKSEDGLGVYGEGSGVIYKKDGDSAYLVTNNHVVKDAEKLEIMMANGKKVVGKLVGSDTYSDLAVIKISSKYVTTVAEFANSDKIKVGEPAIAIGSPLGSDYANSVTEGIVSSLSRTVTSQNENGETISTNAIQTDAAINPGNSGGALINIKGQVIGINSSKIASSNNSNSGVAVEGMGFAIPSNDVVSIINQLEENGEVVRPALGISMANLSEASTSGRDTLKIPSDVTSGIVVLSTQSGMPADGKLKKYDVITEIDGKKVASISDLQSILYKHKKGDKIKLTFYREKDKQTVEIQLTKTSQDLNH","2029677","From GenBANK (gi:14194653): In Lactococcus lactis, HtrA degrades abnormal exported proteins. It is needed for the pro-peptide processing of a natural pro-protein and for maturation of a native protein. This membrane-bound protein is responsible for the housekeeping of exported proteins. HtrA belongs to the peptidase family S2C; also known as the DegP/DegQ/DegS family.From Medline (21391814): The DegP protease, a multifunctional chaperone and protease, has been shown to be essential for virulence in gram-negative pathogens. The function of DegP in pathogenesis appears to be the degradation of damaged proteins that accumulate as a result of the initial host response to infection, which includes the release of reactive oxygen intermediates. Additionally, the DegP protease plays a major role in monitoring and maintaining the Escherichia coli periplasm and influences E. coli pilus biogenesis. The phenotype of an insertionally inactivated degP allele in S. pyogenes is similar to that reported for E. coli, with temperature sensitivity for growth and enhanced sensitivity to reactive oxygen intermediates. Virulence studies in a mouse model of streptococcal infection indicate that a functional DegP protease is required for full virulence. These results suggest DegP as an attractive broad-spectrum target for future anti-infective drug development.","serine protease","Extracellular, Membrane","Several matches in gapped BLAST to serine proteases. Residues 8-400 are 56% similar to putative serine protease of Streptococcus pyogenes (gi15675945). Residues 37-400 are 49% similar to serine protease HtrA of Lactococcus lactis (gi14194653). Also similar to DegP serine protease of S. gordonii (gi15553201) and to hypothetical protease of B. subtilis (gi16081088).This sequence is similar to Spy2216.The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2174 (1e-117).","

InterPro
IPR001254
Domain

Peptidase S1 and S6, chymotrypsin/Hap
PF00089	$\"[121-286]T$	Trypsin

InterPro
IPR001478
Domain

PDZ/DHR/GLGF
PF00595	$\"[317-379]T$	PDZ
SM00228	$\"[298-384]T$	PDZ
PS50106	$\"[284-384]T$	PDZ

InterPro
IPR001940
Family

Peptidase S1C, HrtA/DegP2/Q/S
PR00834	$\"[120-132]T$ $\"[141-161]T$ $\"[182-206]T$ $\"[224-241]T$ $\"[246-263]T$ $\"[342-354]T$	PROTEASES2C

noIPR
unintegrated

unintegrated
G3DSA:2.40.10.10	$\"[56-173]T$ $\"[173-302]T$	no description
PTHR22939	$\"[59-89]T$ $\"[105-395]T$	SERINE PROTEASE FAMILY S1C HTRA-RELATED
PTHR22939:SF10	$\"[59-89]T$ $\"[105-395]T$	SERINE PROTEASE DO/HTRA-RELATED
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[15-35]?$	transmembrane_regions

","BeTs to 13 clades of COG0265COG name: Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domainFunctional Class: OThe phylogenetic pattern of COG0265 is --t-yqvCEBRHuj--oLinXNumber of proteins in this genome belonging to this COG is 1","***** IPB000126 (Serine proteases, V8 family) with a combined E-value of 6.4e-09. IPB000126A 118-133 IPB000126B 229-245","Residues 182-308 are 66% similar to a (PROTEASE SERINE HYDROLASE COMPLETE) protein domain (PD001397) which is seen in O06670_STRPN.Residues 108-180 are 60% similar to a (PROTEASE SERINE HYDROLASE PROTEOME) protein domain (PD001340) which is seen in O06670_STRPN.Residues 329-382 are 42% similar to a (PROTEASE PROTEOME COMPLETE SERINE) protein domain (PD346504) which is seen in Q9Z4H7_LACHE.Residues 311-368 are 62% similar to a (PROTEASE SERINE HYDROLASE) protein domain (PD384761) which is seen in O06670_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Wed Oct 9 13:32:54 2002","Fri Dec 21 18:14:36 2001","Fri Feb 3 08:53:34 2006","Wed Oct 9 13:32:54 2002","Fri Dec 21 18:14:36 2001","Fri Dec 21 18:14:36 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1963 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Fri Dec 21 18:20:36 2001","","No significant hits to the NCBI PDB database.","SMU.2164","","Residues 89 to 286 (E-value = 2.2e-16) place SMu1963 in the Trypsin family which is described as Trypsin (PF00089)Residues 288 to 381 (E-value = 2.2e-10) place SMu1963 in the PDZ family which is described as PDZ domain (Also known as DHR or GLGF) (PF00595)","Tue Jul 5 10:56:47 2005","24380491","","Hal Jones,C., Bolken,T.C., Jones,K.F., Zeller,G.O. and Hruby,D.E. Conserved DegP Protease in Gram-Positive Bacteria Is Essential for Thermal and Oxidative Tolerance and Full Virulence in Streptococcus pyogenes. Infect. Immun. 69 (9), 5538-5545 (2001) PubMed: 11500427Diaz-Torres ML, Russell RR. HtrA protease and processing of extracellular proteins of Streptococcus mutans.FEMS Microbiol Lett. 2001 Oct 16;204(1):23-8.PMID: 11682172 Ahn SJ, Lemos JA, Burne RA.Role of HtrA in growth and competence of Streptococcus mutans UA159.J Bacteriol. 2005 May;187(9):3028-38.PMID: 15838029","Poquet,I., Saint,V., Seznec,E., Simoes,N., Bolotin,A. and Gruss,A. HtrA is the unique surface housekeeping protease in Lactococcus lactis and is required for natural protein processing. Molecular microbiology. 35 (5), 1042-1051 (2000) PubMed: 10712686Jones CH, Bolken TC, Jones KF, Zeller GO, Hruby DE. Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes.Infect Immun. 2001 Sep;69(9):5538-45.PMID: 11500427 ","Fri Feb 3 08:53:34 2006","Sat Oct 26 17:18:54 2002","1","","","SMU.2164","505" "SMu1964","2030140","2030913","774","ATGATGACTGAACAATTAAAATATCTTAATACTAAAGATATTAATCCAAATCCCTATCAACCTCGACTGCAATTTAAAACTAAAGAATTGGAAGAGTTAGCACAATCTATTAAAGAAAATGGCTTAATTCAACCCATTATTGTTCGAAAATCTGATATTTTTGGCTACGATTTGGTTGCAGGAGAAAGGCGCTTAAAAGCAGCAAAATTAGCTGGATTAAATAAGATTCCTGTTATTATCAAAAAAATTTCTGATGATGACAGTATGAAGCAAGCTATTATCGAAAATTTACAACGTTCTGATCTTAATCCTATTGAAGAAGCCAAAGCTTACCAAAATCTCATTAATAGAAATCATATGACTCATGATGATATTGCTAAAGTAATTGGAAAATCAAGACCATATATTACTAACAGTATCAGATTGTTAAATCTTCCTCTGCACATCAGCCAAGCTCTTGAAAAAGGTCTAATTTCTCAAGGACACGCACGACTTCTTTTAAGTATAGAAAAGCAAGACTTACAAGATAAATGGTTCCAAAAAATTCTTACTGAACAGTTAAGTGTGCATCAAATTGAAAGAGCACTTAAAAGTCAAACAAAGAAAGAAAAAAAAACTTCAAAAGACATTTTTCTGGCAGAAAAAGAAAAAGAGCTAAGTCAATCATTAGGCTTACCTGTTGTTATTCATTATAATAAAAAACATCAAGGTCAACTTAAAATTTCTTTTTCGTCCGAAGAAGACTTCAACAGATTAATGAACAAGTTAAACTAG","10.30","11.69","29627","MMTEQLKYLNTKDINPNPYQPRLQFKTKELEELAQSIKENGLIQPIIVRKSDIFGYDLVAGERRLKAAKLAGLNKIPVIIKKISDDDSMKQAIIENLQRSDLNPIEEAKAYQNLINRNHMTHDDIAKVIGKSRPYITNSIRLLNLPLHISQALEKGLISQGHARLLLSIEKQDLQDKWFQKILTEQLSVHQIERALKSQTKKEKKTSKDIFLAEKEKELSQSLGLPVVIHYNKKHQGQLKISFSSEEDFNRLMNKLN","2030925","For other 'spo' genes see SMu0147 (spoU).From GenBANK (gi:586016): Spo0J in B. subtilis is required for the initiation of sporulation and for normal chromosome segregation. It antagonizes sporulation inhibition of SOJ. It probably interacts with a specific DNA site and other proteins involved in partitioning and cell division, and antagonizes SOJ in response to cell cycle events related to chromosome partitioning. This protein belongs to the ParB family.","chromosome segregation protein, ParB-like nuclease domain","Cytoplasm","Several matches in gapped BLAST to chromosome segregation proteins. Residues 1-256 are 57% similar to chromosome segregation protein of Streptococcus pyogenes (gi15675946). Residues 4-256 are 49% similar to Chromosome segregation protein of Streptococcus pneumoniae (gi15902043). Also similar to stage 0 sporulation protein of B. subtilis (gi16081148).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2175 (2e-76).","

InterPro
IPR002197
Domain

Helix-turn-helix, Fis-type
PR01590	$\"[91-108]T$ $\"[126-146]T$	HTHFIS

InterPro
IPR003115
Domain

ParB-like nuclease
PF02195	$\"[7-97]T$	ParBc
SM00470	$\"[7-97]T$	ParB

InterPro
IPR004437
Family

ParB-like partition protein
TIGR00180	$\"[2-183]T$	parB_part

noIPR
unintegrated

unintegrated
SSF109709	$\"[100-194]T$	SSF109709
SSF110849	$\"[6-99]T$	SSF110849

","BeTs to 10 clades of COG1475COG name: Predicted transcriptional regulatorsFunctional Class: KThe phylogenetic pattern of COG1475 is amtK-Q--eBr-uj--OlinxNumber of proteins in this genome belonging to this COG is 1","***** IPB003115 (ParB-like nuclease domain) with a combined E-value of 4.2e-22. IPB003115A 32-48 IPB003115B 56-67 IPB003115C 95-108","Residues 4-87 are 55% similar to a (CHROMOSOME PARTITIONING DNA-BINDING) protein domain (PD002248) which is seen in O06671_STRPN.Residues 32-154 are 26% similar to a (PARTITION PARB-LIKE) protein domain (PD133287) which is seen in Q44031_ALCEU.Residues 30-166 are 29% similar to a (DOMAIN OF UNKNO N) protein domain (PD155485) which is seen in O74043_CERSY.Residues 89-256 are 47% similar to a (CHROMOSOME DNA-BINDING PARTITIONING) protein domain (PD006237) which is seen in O06671_STRPN.","","","","","","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","","","","Mon Aug 21 17:23:09 2006","Mon Aug 21 17:23:09 2006","Mon Aug 21 17:21:32 2006","Mon Apr 8 08:43:07 2002","Fri Dec 21 18:02:33 2001","Fri Dec 21 18:02:33 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1964 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Mon Apr 8 08:43:07 2002","","No significant hits to the NCBI PDB database.","SMU.2165","","Residues 7 to 97 (E-value = 1.5e-34) place SMu1964 in the ParBc family which is described as ParB-like nuclease domain (PF02195)","Fri Dec 21 18:02:33 2001","24380492","","","Mysliwiec,T.H., Errington,J., Vaidya,A.B. and Bramucci,M.G. The Bacillus subtilis spo0J gene: evidence for involvement in catabolite repression of sporulation. J. Bacteriol. 173 (6), 1911-1919 (1991) PubMed: 1900505Ireton,K., Gunther,N.W. IV and Grossman,A.D. spo0J is required for normal chromosome segregation as well as the initiation of sporulation in Bacillus subtilis. J. Bacteriol. 176 (17), 5320-5329 (1994) PubMed: 8071208","","Fri Dec 21 18:02:33 2001","1","","","SMU.2165","742" "SMu1819.1","1882337","1882224","114","ATGAAGGTAAGACCATCTGTTAAACCAATTTGCGAATATTGTAAGGTTATTCGTCGTAACGGTCGTGTTATGGTAATTTGTCCTACAAATCCAAAACACAAACAACGCCAAGGA","11.40","9.07","4434","MKVRPSVKPICEYCKVIRRNGRVMVICPTNPKHKQRQG","","For other 'rl' genes see SMu1909.1 (rl32);SMu0108 (rl28);SMu1840 (rl3); SMu1839 (rl4);SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).","50S ribosomal protein L36","Extracellular, Cytoplasm","The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG0081 (3e-19).This sequence is similar to Spy0076.","

InterPro
IPR000473
Family

Ribosomal protein L36
PD002101	$\"[1-37]T$	RL36_STRPY_Q9A1V2;
PTHR18804	$\"[1-38]T$	FAMILY NOT NAMED
PF00444	$\"[1-38]T$	Ribosomal_L36
TIGR01022	$\"[1-38]T$	rpmJ_bact: ribosomal protein L36
PS00828	$\"[11-37]T$	RIBOSOMAL_L36

","","","","Tue Dec 4 11:36:10 2001","Tue Dec 4 11:36:10 2001","Tue Dec 4 11:38:47 2001","Tue Dec 4 11:39:00 2001","Tue Dec 4 11:39:00 2001","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","Tue Dec 4 11:38:17 2001","Tue Dec 4 11:39:00 2001","Tue Dec 4 11:36:10 2001","Fri Feb 17 12:59:21 2006","Tue Dec 4 11:36:10 2001","Fri Feb 17 12:59:21 2006","Tue Dec 4 11:36:10 2001","Tue Dec 4 11:36:10 2001","Tue Dec 4 11:36:10 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1819.1 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 11:43:03 2002","Tue Dec 4 11:36:10 2001","","","","Residues 1 to 38 (E-value = 2.1e-17) place SMu1819.1 in the Ribosomal_L36 family which is described as Ribosomal protein L36 (PF00444)","Tue Dec 4 11:36:10 2001","","","","","","","1","Tue Dec 4 11:36:10 2001","","","997" "SMu1909.1","1975786","1975965","180","ATGGCAGTACCTGCACGTCGCACTTCAAAAGCGAAAAAAAACAAACGTCGCACACACTATAATTTGACAGCTCCAACTGTGAAATTTGACGAAACTACCGGAGATTACTCACGTTCTCACCGCGTATCCCTCAAAGGATACTATAAAGGACGTAAAATCGCCAAAGCTAACGCTGCGAAA","11.70","14.46","6808","MAVPARRTSKAKKNKRRTHYNLTAPTVKFDETTGDYSRSHRVSLKGYYKGRKIAKANAAK","","For other 'rl' genes see SMu1819.1 (rl36); SMu0108 (rl28);SMu1840 (rl3); SMu1839 (rl4);SMu1837 (rl22); SMu1835 (rl16); SMu1834 (rl29); SMu1832 (rl14); SMu1831 (rl24); SMu1830 (rl5); SMu1827 (rl6); SMu1826 (rl18); SMu1824 (rl30); SMu1823 (rl15); SMu1816 (rl17) and SMu1941 (rl9).","50S ribosomal protein L32","Extracellular","Several weak matches in gapped BLAST to 50S Ribosomal protein L32; e.g. residues 1-60 are 88% similar to 50S Ribosomal protein L32 of Streptococcus pneumoniae (gi|15903984); residues 1-53 are 84% similar to 50S Ribosomal protein L32 of Lactococcus lactis (gi|3122734).The best hit to the Streptococcus agalactiae 2603 V/R genome is to SAG2109 (5e-27).","

InterPro
IPR002677
Family

Ribosomal L32p protein
PF01783	$\"[2-56]T$	Ribosomal_L32p
TIGR01031	$\"[2-55]T$	rpmF_bact

","","","","Tue Dec 4 11:48:32 2001","Tue Dec 4 11:48:32 2001","Tue Dec 4 11:49:52 2001","Tue Dec 4 11:49:52 2001","Tue Dec 4 11:49:52 2001","Fri Oct 25 13:58:44 MDT 2002","Fri Oct 25 13:58:44 MDT 2002","Tue Dec 4 11:49:10 2001","Tue Dec 4 11:49:52 2001","Tue Dec 4 11:48:32 2001","Thu Oct 24 13:21:40 2002","Tue Dec 4 11:48:32 2001","Tue Oct 22 15:48:14 2002","Tue Dec 4 11:48:32 2001","Tue Dec 4 11:48:32 2001","Tue Dec 4 11:48:32 2001","yes","Fri Feb 20 15:41:32 MST 1998","SMu1909.1 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.","Tue Apr 9 11:40:34 2002","Tue Dec 4 11:48:32 2001","","","","Residues 2 to 56 (E-value = 8.9e-22) place SMu1909.1 in the Ribosomal_L32p family which is described as Ribosomal L32p protein family (PF01783)","Tue Dec 4 11:48:32 2001","","","","","","","1","Tue Dec 4 11:48:32 2001","","","987" "SMB0001","1389","4265","2877","GTGGAAACAAGGACTGATAATATTTTTATTAAGTTAAGTGATAATTCAAATATTGAAAAATTGTACAAAAAATTTGGGATGAATCTATTAGAAGATATAAACGCTAGCATAGACGAGTTTGAGGTTTATGAGTCCTGGAATAGATTTCATCTTCTTGGCAGCAATACTTTTTCTAATTTGTATTTATCATTTCTTGAGCCGTATTTACTTGAGATAAGAAATCAATTACAGAAATATGATGACAATTTTCAAAGTGATACCATTGAACGAACTATAACAGAGAATATGTTAGAAAATATTTCTTCTCTATCTGAAGGTGTCTGGATAGCAGAGATGAGAAATATCAATAAAAATCAAACTGAATATTTAGTTTATTTAAATCAGGACTATAAAAATTTAGCAGAAGTTGTTAAGAAGTATCCTTACTGGTATTTTTCAATAATTTCATTTATAAGAGATACCACAAAGTATTTACTAGAGTTTCTTTCTCATTTGATTCAAGATAAAGCCTTGGTTGCTAATCAGTTTTTGGAAGCAGATGGAATGATAACGGATATTAAACTATCTATGGGAGACAGACATAGAGGAACATTTGTCATCAAGGTAGAATCAAAATTCGGTAATTATTTTTATAAACCGAGAAGAAGTAAGTTAGATACATTATTTAAAGAAGTTATAGATAAAATAGGGGAGCAAGATGGAATATTAAAAATGAAAGCTCCTAAAATTATTGATCAAGGAAGCTATTCTTGGGCTGAAGAAATTCGATATATCCCATTACAATCAAAGAATGAAAATGAGAGATATTATATTAGGCTGGGACAGTTATTGGCTATTACATATATACTTAATGGCAGCGATTTACATTATGAAAATATTATATCTTGTGGAGAATTTCCTGTAGCAATAGATGTTGAGACACTTTTGACTAGTAGATTGAGGTTCAAGAAGCAAACGACTCCAAAAATGTTACAAGAGGATAATATTAACTATTTGGAGGACTCTGTAAGTAATTTGATAATATTACCTACAATTGTAAAAAGTAATGGAGATTTTTATGATTTGAGCCCGCTGAAAATATATAGTGGAGAGTTACCAAATACTCTTGCAGAAACTTGGAAAAAATCTAACCATCTAATCCAAAAAAATGAATTGAAAGATGTCATAGGTTTTATACAGAGAGGTTTTATTAATATTTATAATGAGGTTCTCAAAGATAAAGAGCGCTATAAAGAATATTTCAATCGATTATTTAACAATGTTCCTATTCGCTATTTAAATAGAGAAACCCATGACTATTCGCAAATATTAAGACTATTAAAGAATCCGGTGTGCCTATTTCATTTTAAATACGCTTTTGCAGTATCAATGAAACTTTTAAGCGAGGAAATACAGGAAGAAGAAGTACTAGAATACAAAGAATTGTTAAAGTTTAACATCCCATATTTTGAATTAGACACTGATAGTACTGATTTACTTTTATTTGATGATAAGAGAATAAAAAACTACTTTATAGAAACGCCCCTAGAAAGCCTAGAGCATAAACTAAATATACTATGTGAGGAGGATCTTGAAAGACAATTAAGACTAATAACTCAAATGCTGACAGTAGTTTCTGCAGAATTTGACGTAAAAGAGATAAATGAAGTAACAATTCATGAGGGAGAGAGTCTACAAAAGCAAAGGGCGCAGACGGTTGAACAAATGATTGCAACTGTTTTTGAAAATAAACTGATAAATCCATTAACTAAACAATATTTTTGGATAACTCCTGAATTAGAAGGTGATAATAATAGAAGTTTTTACCAAATTCATGAAAATCCTGATAGTTATTATTCGGGTAGCGTTGGAATACTGAGATGTTTGCTACTGCTCGAAAAATCAGGCTATAAAGATTTACCTATTAATAAATTAATAAGTGATATTGAAATTGATATAGATGCAATTATTAATTATGGAACAGTGGACACCAGCATCGGTGCTTACAACGGAATAGCTCAGTATTTAAGATATTATGCTTATATATATAAGAATAACAACTTCAGTGTCTTATCTTTGAAACGCATCCATTACTTATTAGACTTAATAGAAAACGGCTTTAAAAATGATGAGAAATTGGACATCTTAGATGGAACGGCAGGTGTCATATTAACTTTAATAGAGATTTTTCAATTAGATTTGAGTGACTGTTTAAATAATCGTGTGATTAAATTAGTTGAGAAATGTCGCTTACATCTAATAGATTCGATTATTTATGATAAGGGGGAAGCCTATTTTCCTATTGCACAGGAAAAAAATCGTTATTTTACTGGTTTCGCACATGGATCATCTGGAATTACTTTAGCTATTTACAGAGCAAGCAAGCTATTAAATATAGATGACTATACCCTTATTCGATCGTTACTAAAAACAGAAAGACGCTTATTTGATAAGACAAATCAAATGTGGTTTAAGGACAATAATAGAAACAGCTATTCATGGGGATGGTGCCACGGAATTCCAGGTATTCTTTTATCGAGACTTGAGCTTATAAAACATGGCTATCAGGATGACTATATTATTGAAGAAGCTTATGAATTATATGAGATCGCTATAAAAAAATCCCTAGGTGTGAATTTAACTTTTTGTCATGGTGACCTAGGGAACATTGTTATTTGTAAATATGCTGAGGTGATGCTTGATATTGAAAATAGTAAGGTAGATAAATACATTCAAGAAATCTTTCCTTATTTAACAAATGCAACGAGGTATCACATTCGAGGAACTGAAACCATAGGAGTGATGCATGGTTTAGTTGGGGTAGCTACTTTTTTGGACAGTACGATTTGTGATAACTATCTTAGGTTTTTGGATATTTTAAAAATAACATCAGATTAA","","","112158","VETRTDNIFIKLSDNSNIEKLYKKFGMNLLEDINASIDEFEVYESWNRFHLLGSNTFSNLYLSFLEPYLLEIRNQLQKYDDNFQSDTIERTITENMLENISSLSEGVWIAEMRNINKNQTEYLVYLNQDYKNLAEVVKKYPYWYFSIISFIRDTTKYLLEFLSHLIQDKALVANQFLEADGMITDIKLSMGDRHRGTFVIKVESKFGNYFYKPRRSKLDTLFKEVIDKIGEQDGILKMKAPKIIDQGSYSWAEEIRYIPLQSKNENERYYIRLGQLLAITYILNGSDLHYENIISCGEFPVAIDVETLLTSRLRFKKQTTPKMLQEDNINYLEDSVSNLIILPTIVKSNGDFYDLSPLKIYSGELPNTLAETWKKSNHLIQKNELKDVIGFIQRGFINIYNEVLKDKERYKEYFNRLFNNVPIRYLNRETHDYSQILRLLKNPVCLFHFKYAFAVSMKLLSEEIQEEEVLEYKELLKFNIPYFELDTDSTDLLLFDDKRIKNYFIETPLESLEHKLNILCEEDLERQLRLITQMLTVVSAEFDVKEINEVTIHEGESLQKQRAQTVEQMIATVFENKLINPLTKQYFWITPELEGDNNRSFYQIHENPDSYYSGSVGILRCLLLLEKSGYKDLPINKLISDIEIDIDAIINYGTVDTSIGAYNGIAQYLRYYAYIYKNNNFSVLSLKRIHYLLDLIENGFKNDEKLDILDGTAGVILTLIEIFQLDLSDCLNNRVIKLVEKCRLHLIDSIIYDKGEAYFPIAQEKNRYFTGFAHGSSGITLAIYRASKLLNIDDYTLIRSLLKTERRLFDKTNQMWFKDNNRNSYSWGWCHGIPGILLSRLELIKHGYQDDYIIEEAYELYEIAIKKSLGVNLTFCHGDLGNIVICKYAEVMLDIENSKVDKYIQEIFPYLTNATRYHIRGTETIGVMHGLVGVATFLDSTICDNYLRFLDILKITSD$","4265 smbM1","This sequence is taken from strain GS5 and not found in other strains such as UA159.Yonezawa and Kuramitsu (2005) state that the Smb operon is under the regulation of the competence-stimulating peptide (comC, Smu1739) and therefore dependent upon CSP-induced quorom sensing.","modifying enzyme for proSmb from strain GS5","Cytoplasm","Nearest neighbor in the NR db is GI:10173068 (lantibiotic mersacidin modifying enzyme) from B.halodurans.This sequence corresponds to gi55847607 and is similar to gi2853236 (T8 orf1) and gi55847610 (GS5 smbM2).","

InterPro
IPR007822
Family

Lanthionine synthetase C-like
PF05147	$\"[605-954]T$	LANC_like

InterPro
IPR013212
Domain

Mad3/BUB1 homology region 1
SM00777	$\"[684-806]T$	no description

","No hits to the COGs database.","","","","","","","","","","","","","Thu Apr 7 19:37:27 2005","Thu Apr 7 13:17:08 2005","Wed May 4 13:58:54 2005","Thu Apr 7 13:17:08 2005","","","yes","Fri Feb 20 15:41:32 MST 1998","There is no similarity to the UA159 chromosomal sequence.","Wed May 4 13:58:54 2005","","","","","","","55847606","Thu Apr 7 13:17:08 2005","Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209","","Wed May 4 13:57:08 2005","","2","","","","" "SMB0002","4276","5100","825","ATGAGAATTTTAGACATTCAAAATTTAAATTTTAAATATGGAAAAGATTATGTATTGAAAAACATTAATCTTACTTTAGAACAAGGAGATATCCTAGGCTTAGTTGGTGAAAATGGTGCTGGTAAGTCAACTTTGATGAAGCTTATTTCAGGTATCATTCCTAACTATGAAGGAGATATCAAGATTCAAGCTCATAATGTTGGTACTTTAATTGAACACCCCAGCCTCTATGCTGATATGACAGTGTTGAGTAATTTGAAGTTTTACTGTCGTCTATTTGGCAAGAGTTACGGCGTCATTGATGATTATAAATATGTTTTACAGGTGGATAGTTATTTACATAAAAAAGTTTCAAAACTATCTTTGGGGATGAAGCAGAGAGTTGGACTGTTTATTGCTCTCATTGCTTCTGAAGAGTTTATCTTATTAGATGAACCGACCAATGGTCTGGATCCTATTGGTATTAAAAATTTACTGGACTTAATAAAAAAATTATCATCTGAAAAAGGTATTACTTTTATTATTTCCAGCCACATCTTACAAAATTTGGAGCAAATCTGCAACAAAGCAGTTCTGCTGAGAAATCACACAATTAGCAGCTTGGATGCTAAGAAACATATGAAATATAAGATTTATCATCCTGATTTATCTCAATCTGAGCTAATCTGCTTATTAGAAGATAATGGTTTCGACTATGAACAAAATGGTAGGGATATTATTGTTCGTGATATTGATGCCATTGAAGAAATGTTACAAAGAGAGAAGAATATTACTATTCAGAAGGAAAAAATAAGTTTGAGTGAGGTATATTTTGATGAGCAATAA","","","31186","MRILDIQNLNFKYGKDYVLKNINLTLEQGDILGLVGENGAGKSTLMKLISGIIPNYEGDIKIQAHNVGTLIEHPSLYADMTVLSNLKFYCRLFGKSYGVIDDYKYVLQVDSYLHKKVSKLSLGMKQRVGLFIALIASEEFILLDEPTNGLDPIGIKNLLDLIKKLSSEKGITFIISSHILQNLEQICNKAVLLRNHTISSLDAKKHMKYKIYHPDLSQSELICLLEDNGFDYEQNGRDIIVRDIDAIEEMLQREKNITIQKEKISLSEVYFDEQ$","5100 smbF","This sequence is taken from S.mutans GS5 and is not found in strains such as UA159.Yonezawa and Kuramitsu (2005) state that the Smb operon is under the regulation of the competence-stimulating peptide (comC, Smu1739) and therefore dependent upon CSP-induced quorom sensing.","transport and immunity protein from GS5/ ABC ATP binding protein","Cytoplasm, Membrane","Similar to Str1745.Otherwise, nearest neighbor in the NR db is gi2581773 (LctF) from Lactococcus lactis subsp. lactis.This sequence corresponds to gi55847608 and is similar to gi9802352 (CH43 mutF), gi4322367 (T8 mutF), and to a lesser degree to gi9802003, gi4098078, gi55847611, gi4103630, gi9802355, gi4103631, gi9802002, gi5918764.Similar to TF0085.","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[119-162]T$	ABC_transporter
PF00005	$\"[29-196]T$	ABC_tran
PS50893	$\"[4-220]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[28-196]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-207]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-198]T$	PTHR19222
SSF52540	$\"[3-198]T$	SSF52540

","BeTs to 16 clades of COG1131COG name: ABC-type multidrug transport system, ATPase componentFunctional Class: QThe phylogenetic pattern of COG1131 is aompkzy-vdrlbcefghsnujx-twNumber of proteins in this genome belonging to this COG is","","","","","","","","","","","","","Thu Apr 7 19:37:09 2005","Wed May 4 14:14:04 2005","Thu Mar 1 14:41:17 2007","Thu Apr 7 18:51:58 2005","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0596, Smu0944, Smu1649 and several other ABC related genes.","Thu May 5 12:03:37 2005","","","","","","","","","Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209","","Wed May 4 14:14:04 2005","","2","","","","" "SMB0003","5090","5806","717","ATGAGCAATAAATGGGCAACGGTCTTGTTTGTAAGACCAATTATTATGAAATTTAGTGTATTTATTTTTCTGATGCTATCCCTATTGCTTGGTGGGGGAATCATCTATTCTATTGAGAATTTAAAAGGACCTTTTCAGGTTTATAATATCTACAGTGTATTTTCTACTGTTTCCAATTTCTTATTGATGTATGCAGCTATCAACGCCTTTGGTAGAGAGTTTCGCTATAAAACTATCAATCATCTTAGAATCAGTGGGCGATCAAGTATTGAAATTATTTTGAGAAAATTATTAGCAGTTGAGTTTTTAGCTATTTTGACTAGCTTAGTTTCCTTTGTAGAAGTTGCATTTTATAAAATTTATTTTAATCATCCGCAGATTGATTTATTTGAAATTTTTAATCATCTGGTACCGGCTTACTTAGTTTATGCGCTATTTCTCTTTTCATTAGGAAGCATTATCACATTAGTTTTAAAAAATTCATTATATTCATTCATCACTCTATTCCTTACATTAAGATTAGGGGTGACTATCATGAATGTTATGAATAATTTTGAATCTACAGCTGATTTGACTAAATATATTCCTTTATCATTTGTTGAAAATGCCTTTAGTTTTGCTAAATACACTCCGGAACAGTATGTTGTTACTATTGTTTGGAGTGTTGCATTGATGGCATTATTGCCTGTGATTTATCGTAAATGGGGTTATGCATAG","","","27375","MSNKWATVLFVRPIIMKFSVFIFLMLSLLLGGGIIYSIENLKGPFQVYNIYSVFSTVSNFLLMYAAINAFGREFRYKTINHLRISGRSSIEIILRKLLAVEFLAILTSLVSFVEVAFYKIYFNHPQIDLFEIFNHLVPAYLVYALFLFSLGSIITLVLKNSLYSFITLFLTLRLGVTIMNVMNNFESTADLTKYIPLSFVENAFSFAKYTPEQYVVTIVWSVALMALLPVIYRKWGYA$","5806 smbT","This sequence from strain GS5 is not found in UA159.Yonezawa and Kuramitsu (2005) state that the Smb operon is under the regulation of the competence-stimulating peptide (comC, Smu1739) and therefore dependent upon CSP-induced quorom sensing.","predicted transport protein for preSmb from strain GS5","Membrane, Cytoplasm","Nearest neighbor (weak) in the NR db is a hypothetical protein, GI:55823635, from S. thermophilus.This sequence corresponds to gi55847609 in GenBank. No similarity to mutT sequences from mutacins is found.","

noIPR
unintegrated

unintegrated
signalp	$\"[1-31]?$	signal-peptide
tmhmm	$\"[20-38]?$ $\"[48-68]?$ $\"[102-122]?$ $\"[136-156]?$ $\"[161-181]?$ $\"[214-232]?$	transmembrane_regions

","No hits to the COGs database.","","","","","","","","","","","","","Thu Apr 7 19:36:53 2005","Thu Apr 7 18:59:02 2005","Thu May 5 10:57:28 2005","Thu Apr 7 18:56:06 2005","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarity to the chromosomal sequence for strain UA159 is found.","Thu May 5 07:12:53 2005","","","","","","","","","Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730","","Thu May 5 07:12:53 2005","","2","","","","" "SMB0004","5791","8421","2631","ATGGGGTTATGCATAGTGGAAAACATAAGAAATTCGGCCTATCCCAGTATAGAGGGCAAATTTGAAAACTATTTTTCTCACTATATTTCAAAGATATATGAGCAATTATTATCTATTGATTCAAAAGGACTATTCAGCAGCCAAAATGACCAAGAAAAATGTTACTATGCACTTATTGAGGGTATTTTAAAGAATATATCATCAGTAGCAATTAGTTCTCTAATCGACTATTATCAGGAAGAAAGGGCTATAAATCCTAATTTATCATACAAAGATTATAATGAAAATCTTCAAAAAGATAGATATTTTCAAGAATTTCATCAGATTTATCCAACAGTGAAAGATAATTGTGAAGTTGTTATTTGTAATTATATTCAAAGGACTAAAGAAGTATTTAGCCTACTTCAAAATTACCAAGTAGAAATAAGAAACGTTGCTAGTTTAAAAGAAAGTGAGTCGCTGTCTCTTAGTAATCTTAATATCTTTGAAGGTGATTTCCATATTAATACATTTGTAGCTATACTTACACTAAATGAAAAAAGAATATTGATCAAGAAGCGTCCCAATTTAGGGGATCGTCTTTTGAGAATTTTTCAAAAATATTTTGACAAGGAAAATATCAAACTACCTATTGCAAATACAATTTTCTTAGACGATGACTTGTGCCTTCAAGAATACATCAAGTCAGACAGTGCAGTTTTAAATAGCATAGAACTCCAAAATTTTTATTATAAATTCGGAATTATGACAGTTATTTTTACAATTTTAGGAAGTAAGGACCTTCATAGTGAGAATATTATTTCTACAAAATATGGTCCCTATTTTATTGATTTAGAAGCTGCTATAACGGACACACTAAATAGAGAAAAATTAGACTCACTATTGACAGAAACTTATCTATTTAATTCTAAAGAAAAAAGACTTGTATATGGTTCACTAGATTTAAGTGCATTTAGTGGAGGTGATATAACCACTCGGCGGTATGGTGTCATTCATAAGGGGCAAGATGACATTAATATAGGAGTCTACAGTTATACTGAAAAGCATAGTAATATACCACAAGATATAAATGGTGCCAAGGTTAATCCTGAAGAGTATTCAGCAGATGTACTGAAAGGTTTCGATACAGGAATTAGAATTTTTCTAAAATATAAGGAGAGGTTAATTCAGAAACTAGAATTAATAGAGAGCTATGATTATAGGGTTGTACTTCGTAACACGGCTTTTTATGGCAAATATTTAGATGATTTAAACTTACCAATGTACACTAAGAGTAAGGAAAAATCAGAAAAATATATCCACCTATTGAGGAAGCACAGTAAGCGCGATAAAAAAATAGTTGACAAAGAAATGGCTTGTTTGAAACAACAAGCTATCCCTTATTTTTTAATCAGCGAAGTAACTGATAATAAAATAATTAAGGACAACCTCATAAAGAGAATTGAGGGGCTTAGCCTTAGTGATTTAAATAAAGAAAAATACTATTTGCAGCTAATTTTGGGATTAGATGTTCCAATAGAAGGACGATCTCATTATTTGGATAATGGAAACAAAGTGGATAATGAACTACAAGCATTTGAATCATTTTGCTCGAATGATGTGGGTTTTAAATTTGGAGTGATTGATCACACTGTTCAGAATACGCTATTACATTATTGTAATGATATATATACATTTGGCGCTTCTCTCTTGTTTTTAGCTAGATATTGCAAAAATAGTAAATTGAGAGAAAAAATAATAACTACAGTCAGAAATGGTGGCACAAGTGAAGGTCTTTCTGGACTAATAGGTAGACAATCGTCGTACTTACTCTATCATTATTTTAATTTAGAATCTGAGAAGCAAAACTACACATCCTCAAAAGACATAGTACATGAAAAAGATATTGTAGATTTTTCAACGTATGGAAGTGCCATTCTGGTTTTAAACTATCTCTACAAAGAAACTTCAAATAAGGCTTATCTAGATGATATAAAACTATTAGGAGAAATATATTTAAAGACGTACACTAAGCGTAATCTTACTGGTTTGTTTCATGGATATGCAGGCGATATTTTAGTGTTATCAGTTCTCCGCCAATATATAGAACATCAGACTATTGATAAAGATATTCTCGACCTTATTCAACTCGAGAATTCTAATTTTAACAAAGTTTCTAATAATTGGAATGATACTAGGCACAATATTTCTAATACTGAGGATCTATGTGCATTATCGTATGGAGCTGTGGGAATACTTTTTAGTAGGCACTTACTCTATCGTTCATCCAATCTTTACAAGAAATTAAAAGATATTGTTATGACTGATCTCTTTAAAGCTCTTAATTGTATTTTGGTCAGAAATAGGAGCGATTATGTAGATGATTCTCTAGTTAATGGCTATGCAGGTGCTCTTGTAGTTCTAAAAATAATTTTACAATCAGGCTTGTTGAATAACCATTATAGTAAATTGATAAAGGTCAAAACCTATATAGAAGAAGGAGAAAAATTATTAGAAAATACCCAATGGCGTTATGAGCAATTTAATAATCTTTTAAATCCTTCATTTTTTAGTGGAAGATTAGGCACAGCATTTACTTTATGGTTCATAAGCCAAAATGATTTTTATATTGAAAAGTTTTTGGGGGTGTAG","","","101490","MGLCIVENIRNSAYPSIEGKFENYFSHYISKIYEQLLSIDSKGLFSSQNDQEKCYYALIEGILKNISSVAISSLIDYYQEERAINPNLSYKDYNENLQKDRYFQEFHQIYPTVKDNCEVVICNYIQRTKEVFSLLQNYQVEIRNVASLKESESLSLSNLNIFEGDFHINTFVAILTLNEKRILIKKRPNLGDRLLRIFQKYFDKENIKLPIANTIFLDDDLCLQEYIKSDSAVLNSIELQNFYYKFGIMTVIFTILGSKDLHSENIISTKYGPYFIDLEAAITDTLNREKLDSLLTETYLFNSKEKRLVYGSLDLSAFSGGDITTRRYGVIHKGQDDINIGVYSYTEKHSNIPQDINGAKVNPEEYSADVLKGFDTGIRIFLKYKERLIQKLELIESYDYRVVLRNTAFYGKYLDDLNLPMYTKSKEKSEKYIHLLRKHSKRDKKIVDKEMACLKQQAIPYFLISEVTDNKIIKDNLIKRIEGLSLSDLNKEKYYLQLILGLDVPIEGRSHYLDNGNKVDNELQAFESFCSNDVGFKFGVIDHTVQNTLLHYCNDIYTFGASLLFLARYCKNSKLREKIITTVRNGGTSEGLSGLIGRQSSYLLYHYFNLESEKQNYTSSKDIVHEKDIVDFSTYGSAILVLNYLYKETSNKAYLDDIKLLGEIYLKTYTKRNLTGLFHGYAGDILVLSVLRQYIEHQTIDKDILDLIQLENSNFNKVSNNWNDTRHNISNTEDLCALSYGAVGILFSRHLLYRSSNLYKKLKDIVMTDLFKALNCILVRNRSDYVDDSLVNGYAGALVVLKIILQSGLLNNHYSKLIKVKTYIEEGEKLLENTQWRYEQFNNLLNPSFFSGRLGTAFTLWFISQNDFYIEKFLGV$","8421 smbM2","This sequence was taken from strain GS5 and is not found in UA159.Yonezawa and Kuramitsu (2005) state that the Smb operon is under the regulation of the competence-stimulating peptide (comC, Smu1739) and therefore dependent upon CSP-induced quorom sensing.","modifying enzyme for proSmb from strain GS5","Cytoplasm","Nearest neighbor in the NR db is GI:52787803, a hypothetical protein from Bacillus licheniformis ATCC 14580.This sequence corresponds to gi55847610 in GenBank. It is weakly similar to gi2853236, orf1 from strain T8.","

InterPro
IPR007822
Family

Lanthionine synthetase C-like
PF05147	$\"[554-875]T$	LANC_like

","No hits to the COGs database.","","","","","","","","","","","","","Thu Apr 7 19:36:31 2005","Thu Apr 7 19:01:19 2005","Thu May 5 10:59:25 2005","Thu Apr 7 19:01:19 2005","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarity is found to the UA159 chromosomal sequence.","Thu May 5 12:05:50 2005","","","","","","","","","Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209"," Novak,J., Caufield,P.W. and Miller,E.J.Isolation and biochemical characterization of a novel lantibioticmutacin from Streptococcus mutansJ. Bacteriol. 176 (14), 4316-4320 (1994)8021218 Chikindas,M.L., Novak,J., Driessen,A.J., Konings,W.N.,Schilling,K.M. and Caufield,P.W.Mutacin II, a bactericidal antibiotic from Streptococcus mutansAntimicrob. Agents Chemother. 39 (12), 2656-2660 (1995)8592997REFERENCE 3 (residues 1 to 898) AUTHORS Woodruff,W.A., Novak,J. and Caufield,P.W. TITLE Sequence analysis of mutA and mutM genes involved in the biosynthesis of the lantibiotic mutacin II in Streptococcus mutans JOURNAL Gene 206 (1), 37-43 (1998)","Thu May 5 07:17:21 2005","Thu May 5 07:17:21 2005","2","","","","" "SMB0005","8458","10554","2097","ATGAGCCAAACAGAATGTGGATTATGTGTTGCTGTAATGTTAATGGAATACTATGATGTTCGCATAACTTTGAATGATATTCCTAAAGAATTCTCTGCGGGAAGAGACGGGACGCGTATTAGGGGACTTAAGAAAATTTTTGACCACTTTGGTTTTTCCATGAATATGTTTAAGGTGACTGATAGACTCTCAGAAATAAAAAACTCCTCGTTACCAGGCATCGCTTATAGAATCGGAGGACATTTTGTCGTAGTAGAGTCAATCTCTTCTAATGAGGTTATTATATTGGATCCAGCTTTTGGGCGAACAAAAATTTCAAAAGATGAACTTGATAATGACTATAAAAATTTAATACTTAAGATAACGCCTAACGAAAATTTTAAAACCGTTAATACTAGAGGACAAGAATTTTCACTGATTAAAGAAGCAGTATTCTTTAACAAGAAACTCGTTGTACAGGTGCTTATTGCAGCGGTAATTGTCTATTCGTTGACACTAGTTGCTCCGTTACTATTAAAAGGACTTGTTGATAATTTTTTAGTTAGCAAACAGATAGATACTACAATTTGGGCGCTATCTATAGGTACAATCGCAAGCAGTTTGGTCTACTTTGTAGTGAATAGAGTCAAGCAAATTACTAGCATCCGTCTGTCTATCTCCGTTGATAAATTCTTATCAAAAAAGGTTGTTGATAAATTATTTAAAAATAAATTTGAATTTTATCTTAACCGTACTAGCTCGGATATCCAATATAGATTAGTACTATTAAAAAATTTAAAAACGATAATTAGTGATATTATCATTCAAACTTTTTTAGATATAGGTTCTATGGTTGTTATCCTCATTTACATTATGAATTTACAACCTTTATATGCAGTCTTTTTAGCATTTATTACATTGCTAGTATTATCCATGAGCAGGTTTATGCGAGAGAAAATGTTGCTGTACAAAAACAAGGAGTTGGCAACGGATAGTAAATTGCAAGTTTTTCAGTATGATATTTTTCGTGCAATTTTTGATGTAAAAGTGTTAGGGCTAAGCTCAAAAAAGCATAGGTCGTGGCATAGATATTATGAGGATTATATCAAGTCTCATGAAAAAAATCAGCGATTTATCACTTTGTATCAAAATATACTAGCATATATTACACTTTATGTACCAATTTTCATTCCTATCTTAGGAATTTGGATTAGTGGATTGGCTCACAGTAACCAAGTTGGAACGATTATATCTTTACAATCGATTACAGGTACATACATTTCAGGTCTAATCTCCATAGCTCAATTATCAGACAATATTACAACAGCAAAGTCTTACCTCATACGTATAGATGACATCCTTTTGCAGGAGGACGAAGCAGTAAGAAATCGTACAATAGATTTTAAAGGGAATATAAGGGTAAACAACTTGTCATTTGTCTATCCCGGTGCCGAAGACAAAACATTAGATGATATTAGTTTTTCAATTAATGAAGGCGAGTCTGTAGCCATTGTTGGCGAAAGTGGTTCTGGTAAGTCTACGTTGTTTTATATATTGTTAGGTGCTTATGATAACTATGAAGGTGATATATACTTTGAAGGACTAGATTTAAAGATTTTAAACAAAGATGCTTTACGTGAGCAGATAGGAGTGGTTCCTCAGGATGCCTTATTGTTTAACGGAAGTATAAAAGAAAATTTAATTGAAGATTTCGAGGTTGCTGATAATGATATATATGACGCTCTAAAAAAAGTTACTCTGCTTGATTTTGTTTATTCATTGCCTATGGGGATTAATACAGTAGTATCGGAAAATGGGTTCAACTTCTCAGGAGGACAGAGACAGAGACTAGCTTTGGCCAGAGCTATTTTAAATCAAAAATCAATGCTATTCTTAGATGAAGCAACGAGTGCTCTTGATAATATTACTGAGCATCAAATTGTAGAATATTTATCTGAAGATTCTAAAACAAAGATTGTTATTGCTCATAGATTAAGCACTATAAAAAATAGTGACAAAATAATTGTTTTAAAAGACGGTCAAGTGTCTGAAGTTGGAGACCATCATAGCTTGATGGCTCAAAAGGGAGAATATTACCGAATGTATTCTGGTAAATAA","","","79098","MSQTECGLCVAVMLMEYYDVRITLNDIPKEFSAGRDGTRIRGLKKIFDHFGFSMNMFKVTDRLSEIKNSSLPGIAYRIGGHFVVVESISSNEVIILDPAFGRTKISKDELDNDYKNLILKITPNENFKTVNTRGQEFSLIKEAVFFNKKLVVQVLIAAVIVYSLTLVAPLLLKGLVDNFLVSKQIDTTIWALSIGTIASSLVYFVVNRVKQITSIRLSISVDKFLSKKVVDKLFKNKFEFYLNRTSSDIQYRLVLLKNLKTIISDIIIQTFLDIGSMVVILIYIMNLQPLYAVFLAFITLLVLSMSRFMREKMLLYKNKELATDSKLQVFQYDIFRAIFDVKVLGLSSKKHRSWHRYYEDYIKSHEKNQRFITLYQNILAYITLYVPIFIPILGIWISGLAHSNQVGTIISLQSITGTYISGLISIAQLSDNITTAKSYLIRIDDILLQEDEAVRNRTIDFKGNIRVNNLSFVYPGAEDKTLDDISFSINEGESVAIVGESGSGKSTLFYILLGAYDNYEGDIYFEGLDLKILNKDALREQIGVVPQDALLFNGSIKENLIEDFEVADNDIYDALKKVTLLDFVYSLPMGINTVVSENGFNFSGGQRQRLALARAILNQKSMLFLDEATSALDNITEHQIVEYLSEDSKTKIVIAHRLSTIKNSDKIIVLKDGQVSEVGDHHSLMAQKGEYYRMYSGK$","10554 smbG","This sequence was taken from strain GS5 and is not found in UA159.Yonezawa and Kuramitsu (2005) state that the Smb operon is under the regulation of the competence-stimulating peptide (comC, Smu1739) and therefore dependent upon CSP-induced quorom sensing.","transport and immunity protein for preSmb from strain GS5","Membrane, Cytoplasm, Extracellular","Nearest neighbor in the NR db is GI:52082411, a predicted transport protein, lanT, from B. licheniformis ATCC 14580. Similar to TF2429, TF2710 and others.This sequence corresponds to gi55847611 in GenBank. It is similar to gi4103630 (T8), gi9802002 (CH43), gi5918764 (UA787) and other ABC related genes in S.mutans.","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[151-338]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[601-644]T$	ABC_transporter
PF00005	$\"[492-673]T$	ABC_tran
PS50893	$\"[465-697]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[491-674]T$	AAA

InterPro
IPR005074
Domain

Peptidase C39, bacteriocin processing
PF03412	$\"[1-126]T$	Peptidase_C39
PS50990	$\"[3-121]T$	PEPTIDASE_C39

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[154-435]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[430-695]T$	G3DSA:3.40.50.300
PIRSF002787	$\"[1-697]T$	Hemolysin_sec_B
PTHR19242	$\"[148-695]T$	PTHR19242
PTHR19242:SF91	$\"[148-695]T$	PTHR19242:SF91
SSF52540	$\"[465-695]T$	SSF52540
SSF90123	$\"[106-614]T$	SSF90123

","BeTs to 6 clades of COG2274COG name: ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domainFunctional Class: QThe phylogenetic pattern of COG2274 is -----------lbcefg-sn-j---wNumber of proteins in this genome belonging to this COG is","","","","","","","","","","","","","Thu Apr 7 19:36:14 2005","Thu Apr 7 19:07:23 2005","Thu Jul 14 13:52:14 2005","Thu Apr 7 19:07:23 2005","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0258, Smu1710, Smu0815, Smu0837 and several other ABC permease related sequences from the UA159 chromosome.","Thu May 5 07:54:05 2005","","","","","","","","","Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209","","Thu May 5 07:51:29 2005","","2","","","","" "SMB0006","10653","10838","186","ATGAAAAGTAATTTATTAAAAATAAATAATGTAACAGAGATGGAAAAAAATATGGTAACGCTCATCAAAGATGAAGATATGTTAGCTGGGGGCTCTACTCCGGCATGTGCAATTGGGGTTGTTGGTATTACTGTAGCAGTTACTGGTATATCAACTGCGTGCACATCTCGCTGTATTAACAAATAA","","","6340","MKSNLLKINNVTEMEKNMVTLIKDEDMLAGGSTPACAIGVVGITVAVTGISTACTSRCINK$","10838 smbA","This sequence was taken from strain GS5 and is not found in UA159.The SmbA and SmbB peptides are thought to make up the mature bacteriocin.Yonezawa and Kuramitsu (2005) state that the Smb operon is under the regulation of the competence-stimulating peptide (comC, Smu1739) and therefore dependent upon CSP-induced quorom sensing.","SmbA bacteriocin precursor from strain GS5","Cytoplasm, Extracellular","No sequence from the NR db qualifies as a nearest neighbor. Yonezawa and Kuramitsu (2005) claim a similarity exits to lacticinA2 from L.lactis.This sequence corresponds to gi55847612 in GenBank. No similarity is found to other mutacin precursors.","

noIPR
unintegrated

unintegrated
tmhmm	$\"[34-54]?$	transmembrane_regions

","No hits to the COGs database.","","","","","","","","","","","","","Thu Apr 7 19:35:54 2005","Thu Apr 7 19:16:23 2005","Thu May 5 11:02:03 2005","Thu Apr 7 19:16:23 2005","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarity is found between this sequence and the UA159 chromosome.","Thu May 5 07:56:24 2005","","","","","","","",""," Petersen FC, Fimland G, Scheie AA.Purification and functional studies of a potent modified quorum-sensing peptide and a two-peptide bacteriocin in Streptococcus mutans.Mol Microbiol. 2006 Sep;61(5):1322-34. PMID: 16925560Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209","","Thu May 5 07:56:24 2005","","2","","","","" "SMB0007","10866","11054","189","ATGAAAGAGATTCAAAAAGCAGGCTTGCAAGAAGAGTTATCAATTCTCATGGATGATGCTAATAACTTAGAACAACTTACTGCTGGTATTGGTACAACAGTAGTAAATTCTACTTTTAGCATTGTATTGGGAAATAAAGGTTATATCTGTACGGTTACTGTTGAATGCATGAGAAATTGTAGTAAGTAA","","","6707","MKEIQKAGLQEELSILMDDANNLEQLTAGIGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK$","11054 smbB","This sequence was taken from strain GS5 and is not found in UA159. The SmbA and SmbB peptides are thought to make up the mature bacteriocin.Yonezawa and Kuramitsu (2005) state that the Smb operon is under the regulation of the competence-stimulating peptide (comC, Smu1739) and therefore dependent upon CSP-induced quorom sensing.","SmbB bacteriocin precursor from strain GS5","Cytoplasm, Extracellular","No sequences in the NR qualify to be near neighbors of this sequence.This sequence corresponds to gi|55847613 in GenBank. Only extremely weak similarities may be noted to mutacin modifying enzymes.","No hits reported.","No hits to the COGs database.","","","","","","","","","","","","","Thu Apr 7 19:44:47 2005","Thu Apr 7 19:35:33 2005","Thu May 5 07:58:16 2005","Thu Apr 7 19:35:33 2005","","","yes","Fri Feb 20 15:41:32 MST 1998","","","","","","","","","",""," Petersen FC, Fimland G, Scheie AA.Purification and functional studies of a potent modified quorum-sensing peptide and a two-peptide bacteriocin in Streptococcus mutans.Mol Microbiol. 2006 Sep;61(5):1322-34. PMID: 16925560Yonezawa H, Kuramitsu HK.Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5.Antimicrob Agents Chemother. 2005 Feb;49(2):541-8.PMID: 15673730Wang BY, Kuramitsu HK.Interactions between oral bacteria: inhibition of Streptococcus mutans bacteriocin production by Streptococcus gordonii.Appl Environ Microbiol. 2005 Jan;71(1):354-62.PMID: 15640209","","Thu May 5 07:58:16 2005","","2","","","","" "MI0001","1016","1885","870","TTGAAAGTAAATCAATCAATGGAATTAGGTGAACTTTATCGAGAATTAAGAATTGCTAGAGGTTTGAAGATAAAAGATATAGCTTGTAAAAATCTGTCCAAGTCACAACTCTCTAGATTTGAAAATGGACAAACCATGTTGGCAGCTGATAAATTGCTATTAGCTATTTCGGGAATTCATATGAGTTTTTCGGAATTTGGATATGCTTTGAGCCATTATGAGGAGAGTGATTTTTTCAAAAGGGGTAATAAGTTATCAGAATTATATGTCCAGAAAGATATCAAAGGATTAAAAAAGTTATTAGAATTTAATGACAATCATGAGGTATTTGATGTCTACAATCGTTTAAATAAATTGGTTATTCAAGTTACTATTCATTTGCTAGATACTGATTACATAATATCAGATGATGATAAGAATTTTTTAACAACTTATCTATATAATATTGAAGAGTGGACTGAGTATGAACTTTATATCTTTGGGAATACTATGTCTATATTGTCATCTGATGATTTAATTTTTTTGGGAAAAGCTTTTGTAGAACGTGATAAGTTGTATATATCTCTTCCTAGTCATAAGAAAAATGCAGAGTTAACTTTTTTAAATTTAATCTTAATTTTGCTTGAAAGAAAAAAATTATATCAAGCAATCTATTTTGTAGAGAATTTAGAGAAATTATTAAATTACCAAGATATGTTTGCAATAACATTTTTAAAATTTTTAAAAAAAATTATTACTTACTTTCATGATAAGTCAGTAGATATGTCTGAATTAGAACATTATATTAATATAGTTGAAGAAATAAATCCTACGATTGCTTCAATTCTTAAATCTAATTTGAATCAGCTTTTATCAAGTTTTAGCCATTAA","","","33882","LKVNQSMELGELYRELRIARGLKIKDIACKNLSKSQLSRFENGQTMLAADKLLLAISGIHMSFSEFGYALSHYEESDFFKRGNKLSELYVQKDIKGLKKLLEFNDNHEVFDVYNRLNKLVIQVTIHLLDTDYIISDDDKNFLTTYLYNIEEWTEYELYIFGNTMSILSSDDLIFLGKAFVERDKLYISLPSHKKNAELTFLNLILILLERKKLYQAIYFVENLEKLLNYQDMFAITFLKFLKKIITYFHDKSVDMSELEHYINIVEEINPTIASILKSNLNQLLSSFSH$","1885 mutR","See sequences for strain CH43, also classified as a mutacin I.","transcriptional regulator for the mutI operon in strain UA140","Cytoplasm","This sequence corresponds to gi12082656 in GenBank. Nearest neighbor in the NR db is GI:15902184 from S.pneumoniae.This sequence is similar to gi9801995 (CH43, gi5918757 (UA787), gi4102023 (T8), gi3047245 (JH1005).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
SM00530	$\"[12-66]T$	HTH_XRE

InterPro
IPR010057
Domain

Transcriptional activator Rgg/GadR/MutR, C-terminal
TIGR01716	$\"[68-286]T$	RGG_Cterm: transcriptional activator, Rgg/G

","","","","","","","","","","","","","","Thu May 5 09:05:35 2005","Wed Apr 27 09:56:43 2005","Thu May 5 10:29:29 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0099 and Smu1371 in strain UA159.","Wed Apr 27 10:42:41 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).","Wed Apr 27 09:56:43 2005","Wed Apr 27 10:08:18 2005","3","","","","" "MI0002","2457","2654","198","ATGTCAAACACACAATTATTAGAAGTCCTTGGTACTGAAACTTTTGATGTTCAAGAAGATCTCTTTGCTTTTGATACAACAGATACTACTATTGTGGCAAGCAACGACGATCCAGATACTCGTTTCTCAAGTTTGAGTTTATGTTCATTAGGATGTACAGGGGTGAAAAATCCTAGTTTCAATAGTTACTGTTGCTAA","","","7049","MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTRFSSLSLCSLGCTGVKNPSFNSYCC$","2654 mutA","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).The mutA product is post-translationally modified to become a 24-amino acid bacteriocin.See sequences for strain CH43, also classified as a mutacin I.","prepromutacin; MutA protein from strain UA140","Extracellular, Periplasm","This sequence corresponds to gi12082657 in GenBank. No sequence similarities were found in the NR at this time.This sequence is similar to gi9801996 (CH43), gi3047246 (JH1005), gi5918758 (UA787), gi5918759 (UA787), gi9801997 (CH43), gi3047247(JH1005).","

InterPro
IPR006079
Family

Lantibiotic
PF02052	$\"[12-65]T$	Gallidermin

","","","","","","","","","","","","","","Thu May 5 09:06:00 2005","Wed Apr 27 09:58:43 2005","Thu May 5 10:31:29 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","No paralogs were found to this sequence.","Tue Apr 26 13:15:06 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423Li S, Liu T, Xiao X, Yang J, Yang D, Zhuang H, Liu Z.Detection of mutA genes in transmitted strains and nontransmitted strains of mutans streptococci.Caries Res. 39(5):417-21.PMID: 16110215","","Thu Apr 26 09:26:14 2007","","3","","","","" "MI0003","2723","2917","195","ATGTTAAACACACAATTATTAGAAGTCCTTGGTACTAAAACTTTTGATGTTCAAGAAGATTTATTTGAGTTTAATATAACAGATACTATTGTACTGCAGGCTAGTGATAGTCCAGATACTCATAGTAAAGTGGGTAGTTTCAGTATCTGTCCTCCTCGAAAGACCTCCGTCAGTTTCAATAGTTACTGTTGTTAA","","","7103","MLNTQLLEVLGTKTFDVQEDLFEFNITDTIVLQASDSPDTHSKVGSFSICPPRKTSVSFNSYCC$","2917 mutA'","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).\"The MutA' product is not required for mutacin I activity \"(( Chen and Caufield, (2000))).See sequences for strain CH43, also classified as a mutacin I.","MutA' protein from strain UA140","Extracellular, Periplasm","This sequence corresponds to gi12082658 in GenBank. No similarites were found in the NR at this time.40)This sequence is similar to gi5918759(UA787), gi9801997(CH43), gi3047247(JH1005), gi5918758(UA787), gi9801996(CH43), gi12082657(UA140).","

InterPro
IPR006079
Family

Lantibiotic
PF02052	$\"[12-64]T$	Gallidermin

","","","","","","","","","","","","","Wed Sep 27 13:43:58 2006","Wed Sep 27 13:43:58 2006","Wed Sep 27 13:43:58 2006","Thu May 12 13:52:30 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","No paralogous sequences are found for this sequence.","Tue Apr 26 13:20:12 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423","","Wed Apr 27 10:02:24 2005","","3","","","","" "MI0004","3072","6044","2973","ATGAACGATTTTCAATTTCAAGATTATTTTATGTACAGAAAACCATTAGGCAACTTTTCTAATTTTCTTAGTATAACTGATATGATGGATCCTATTGAATTATTACATAATGATTCGATATTTGCTGAAGGGGTATATTTGGCTTCCCCATCTCTTAGATCATCTATAAATAAATTAGAGAATCAGATTGCAAGTACTAAGGAAAAAAAGAATGCAAAAGAGACTATTTTTCAATACTATGCCCGTTATAACACGAGACCAACTCCGTTTGGCTTGTTTTCGTCCATCGGAATAGGTGGTTTTTCGACCCACCCTAGGAAAGAGAAATCTTGTTATGAAAAATCTGTTAATGTTGATCTTTTTTGGGCTTATAAAGTAGCAGATAAACTAGAAAGTATGCCTGAAATTTTAAATACTTTAAAAGTAGTTGCTAATAATGCTTTGCAAAAGTCAAATGATTTTTGGCTTTTAGATACACGAAGTCATTTTGGACTTATGAATTCACGTTCAGATATTCGTGAGGACATTACAGTTAAGTCTAATCAGCTTATAGATTATGTTATTAATTGCACAGAAGAACCAATTAGCTATCAAACATTAATTGATGATATTGCCGAGAAATTCTCTCAATCTAGTGATGATGTAAAAGAATATTTGCAAAAATTAATTAAAGAGGAGTTTTTAATAACTGAATTGAAATTTAGTTTGATTGAAGACAACCCTTTGGATTGGTTTATTAATATTTTAGAAAGAGATCAAAATAACTCAGAATTACTTGAAAAGTTGACTGAAATAAAGGCAATGATTCAAGATTATACTGACCGTAACATAGGTGAAGGTAACAATTCGATTTTAGCTCTAGAAAATAAGATGAGCCAAATAGTAAAAGCCAACGCATACCTGCGAGTTGATCTTTATGATCATGCAGAGCTGAAGTTAGCGCAACATACCAAGAGTTCTCTTCAGAATATTTTGAAAGTACTAAGTTCTTTTTCGTCAGCTGTTAATAGTCAAAAAGAAATTAAAAATTATCATGAGAAATTTATTGCCAGGTATGGATACGAGCGGTTAGTACCTCTTCAATTACTTTTGAATTCTACTAGTGGACTTGGTTTTCCAAAAGGGTATAGTCAAACAGAAGTTTCTAAACAAAATAATGAAGATAGTAAAAATCAAAAAATAATAGAATTTTTACAGAGAAAATTTGAAAAAGCTTTAAGAGATGGTAAAGAAATTATTTTGAGTGATGATGATTTAAAAGATTTAAATTTTGACACGGAACAGCAAATATCAGGAGAATTATATTGTTTCTACAATTTTAAAAGTAAAAAGCTAGAGGTTAGTAGTTTAGGTGTCTCACAGATACTTGGAAATACTTTTGGACGTTTCCATTCTAAATTGCCGAATACGATAGTCACAAAAAATGTAAATAAGACGAAAGAAATTTTTACTGAGGCTTATCCAAATACTATTATTACTCAATTAAATGAAGTGCCATATTTTGGGAGAGGTGGCAATATTATGATTAGTAATAGCCTTAAAAGTCACCAGTTGGAATTGAGGAACTATACTACTAAAAAAGAGATGAGTATCAATGATATTTATGTAGGTGCAACCAGTGAGGAGTTATATTTTTATTCTAAGAAATATGAGAAAAGAGTTATTTTTGTGATGAATAATATGTTTAATTATATAAATGGTTCTAAACTCTTACGTTTTTTACTAGAAGTTTCAAATTCTGATTTTCAAAATATTACCCCGATTACGCTTGGTAGTCTGGATTCTTATAATCATGTGCCCGCTATCATTTATAAAGATATTATTATTAAACCGGAAACATGGGACATTAGAAAATCTGAAGCTAAGACTTTAGATTCTCTCAAAAATTGGCTAACTAATAATAATGTTCCGCCTTTTGTACGGATGAAATATACTGATCAAATTATTTATTTAGATTTGAGTCGGACTATTGATTTAACTATGCTATTTCAGAGTATCAAAAAACATAGCTTCATACAATTATTAGATGTTCATTCAGTATGTACAAACGATACGGAGATTTTAGAATTAGTTGTTCCTTTTACAAGAAGTGATGTTAACGCTCACCAGATTTATCATTATGCTCAGAATATTTATACTTTGGAGGATTCAGGTAGTAAAGAAAAATATTTTTACGCTAAAATTTATGTGAATAAACAACGACAGACCTCTTTCCTACAAAAAGAGTATCCTTTATTATTAAACTATTTGAAACTCCCAGAAAACTTACAATGGTTCTATATTAGATATAAAGATGATGGAAAAGACAGCATACGTCTCAGAATCAGATATGTAGAAGATAAACAATTAGTTCAACTTTATTCACGCTTTATAGAGTGGGCAACAAAAGCACGGAAAAATATCCAAATTTCAGGTTATGAAATTAGTGAATATATCCCTGAATCAGCAAGATATGGAGGGAAAAAATATTCTTCAATTATTCATTCTTTTTTCTATTATGATAGTATTTTGGATTTGCTTTTACAGAAGAAAGCAGAACAAACTATTGAAGTAAGAACATCTCTCAGTATTATTCGTATGTTTTTAATGATGAAATTAAGCTTACAAGACCAGCAGAAACTCATAAAGAATTTATTTGATGGAAAACATAAACTTAAATATGAAAAAGAATATCATAATTCAATAAGTTTATTACTTGACAATTTATGTACAAAAAATCAGACAGATGAAGCTGATATTTTCTGTGTAATGAATATGAAAAAAATCACTGAAAAAATTAGCTCAGTTCTTAAACAAAAGGACTTAACAACAGATTGGCAGAGAATTCTAGGAAGTTTAATTCATATGCGATGTAATCGAGTATATGGAATTAACAGTGAGTTAGAAAGAAAAACAATGTTTATTGTTGACAAAGTTATTAATTCAAAAAGATATACGGATATGTTTTTGGAGGTGGGTAATGAGACAAAGTAA","","","115743","MNDFQFQDYFMYRKPLGNFSNFLSITDMMDPIELLHNDSIFAEGVYLASPSLRSSINKLENQIASTKEKKNAKETIFQYYARYNTRPTPFGLFSSIGIGGFSTHPRKEKSCYEKSVNVDLFWAYKVADKLESMPEILNTLKVVANNALQKSNDFWLLDTRSHFGLMNSRSDIREDITVKSNQLIDYVINCTEEPISYQTLIDDIAEKFSQSSDDVKEYLQKLIKEEFLITELKFSLIEDNPLDWFINILERDQNNSELLEKLTEIKAMIQDYTDRNIGEGNNSILALENKMSQIVKANAYLRVDLYDHAELKLAQHTKSSLQNILKVLSSFSSAVNSQKEIKNYHEKFIARYGYERLVPLQLLLNSTSGLGFPKGYSQTEVSKQNNEDSKNQKIIEFLQRKFEKALRDGKEIILSDDDLKDLNFDTEQQISGELYCFYNFKSKKLEVSSLGVSQILGNTFGRFHSKLPNTIVTKNVNKTKEIFTEAYPNTIITQLNEVPYFGRGGNIMISNSLKSHQLELRNYTTKKEMSINDIYVGATSEELYFYSKKYEKRVIFVMNNMFNYINGSKLLRFLLEVSNSDFQNITPITLGSLDSYNHVPAIIYKDIIIKPETWDIRKSEAKTLDSLKNWLTNNNVPPFVRMKYTDQIIYLDLSRTIDLTMLFQSIKKHSFIQLLDVHSVCTNDTEILELVVPFTRSDVNAHQIYHYAQNIYTLEDSGSKEKYFYAKIYVNKQRQTSFLQKEYPLLLNYLKLPENLQWFYIRYKDDGKDSIRLRIRYVEDKQLVQLYSRFIEWATKARKNIQISGYEISEYIPESARYGGKKYSSIIHSFFYYDSILDLLLQKKAEQTIEVRTSLSIIRMFLMMKLSLQDQQKLIKNLFDGKHKLKYEKEYHNSISLLLDNLCTKNQTDEADIFCVMNMKKITEKISSVLKQKDLTTDWQRILGSLIHMRCNRVYGINSELERKTMFIVDKVINSKRYTDMFLEVGNETK$","6044 mutB","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).See sequences for strain CH43, also classified as a mutacin I.","modifying enzyme; MutB protein from strain UA140","Cytoplasm","This sequence corresponds to gi12082659 in GenBank. Nearest neighbor in the NR db is gi478636 from Staphylococcus epidermidis.Similar to TF1128.This sequence is similar to gi9801998 (CH43), gi5918760 (UA787), gi3047248 (JH1005).","

InterPro
IPR006826
Domain

Lantibiotic dehydratase, N-terminal
PF04737	$\"[21-161]T$	Lant_dehyd_N

InterPro
IPR006827
Domain

Lantibiotic dehydratase, C-terminal
PF04738	$\"[195-675]T$	Lant_dehyd_C

","","","","","","","","","","","","","","Thu May 5 09:06:19 2005","Wed Apr 27 10:03:57 2005","Thu Jul 14 13:39:22 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","There are no sequences paralogous to this sequence.","Tue Apr 26 13:25:45 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423","","Wed Apr 27 10:03:57 2005","","3","","","","" "MI0005","6031","7308","1278","ATGAGACAAAGTAAACGTGTCGAAAAAATTAAAGATATTCCAACTGAGCAAACTTATTTATTCGATTATCAAGAAATATTAAAAAAAGTCAGTCAAGCAAAACAAACAGATTTTTGGAATTTACTTTCCTTATCTTCGGGAATAACTTCTTTATTAATATTTTATCAAGAGTATGAGAATTTAGAAGGAGTAAACTTAAAGCAGCAAAAGCAGTCATTAATTGGGCTTATAAGTCATTATATTAATCAAATAGCAGAGAAATCCTCTTTATTTGATGGTTTAGCTGGGGTAGGTTTTGCTATTAATTATATCTCTAATAACGGTAAATATTATCAAAAACTTCTTGAACAGATTGACAACAGACTCCGTCAGAATATTGAACGGGACCTTGTCAACTATAAGAATGAGGAATATGCAAATCCTAATGAATTAATGATGTACGTTTCTGGAAATGCTGGAGTAGCTCGCTACTTGATGGAAAGAGAATCCTCTGAAGATTGGCGAATTGTTGAAATGATTTTAGAAGTATTTTATAAAGCTTTGGAACAAGGCTGGCGAGTGCAACCAAAATATCAATTTTTAGAATCTGAAAAGCAATATTATTTAAAGGGAAATATAAACTTTGGTTTAGCTCATGGATTATTAGGTCCTACAACAATTATGTCTCTTTATCAGCAGAGGTACCCACAGAACACAAGAAATGCTGAGAAACTTCAGGAGACTTATCATTTTATAAAAAGATATGCTCAACTAAGAGATGAAGGGCTACGATGGGCAATACGATATGATTTGTTTCGTAAAGAGGGTTCTTTTATATTACGAAATGGTTGGTGTTATGGCGAGAATGGCATTTATAATACACTTTTTCTTATGGGAAAAGTACTCTCAAATCAGGAGATTTGTGAAACTGCTCAGAAAGTTATACCATCCATCATAAAAGATGATTATGAGAAAATGGGAAGTCCAACATTTTGTCATGGGTTTGCTGGAAAAGCAAATTTCTTTCTTCTGCAATATCAAAGAACTAAAGAATCAATATTTTTAGTTAAAGCAGAAGAAGAAATTGATAAAATATTAATTGTGTACAATTCTGAAAATATGTTTGGATTTAAAGATATAGAAGATAATATTGATAATACTGGAGAGAGATTAACTTATTGGGATAATTTTGGTCTTCTTAGTGGAACTGTTGGTGTTCTATTAGTTTTGATGGAATATTGTAATATTGTAAATGCCGGAAAAATTGCAGAGTGGAATAAAATTTTTCTTTTGACTTAA","","","49727","MRQSKRVEKIKDIPTEQTYLFDYQEILKKVSQAKQTDFWNLLSLSSGITSLLIFYQEYENLEGVNLKQQKQSLIGLISHYINQIAEKSSLFDGLAGVGFAINYISNNGKYYQKLLEQIDNRLRQNIERDLVNYKNEEYANPNELMMYVSGNAGVARYLMERESSEDWRIVEMILEVFYKALEQGWRVQPKYQFLESEKQYYLKGNINFGLAHGLLGPTTIMSLYQQRYPQNTRNAEKLQETYHFIKRYAQLRDEGLRWAIRYDLFRKEGSFILRNGWCYGENGIYNTLFLMGKVLSNQEICETAQKVIPSIIKDDYEKMGSPTFCHGFAGKANFFLLQYQRTKESIFLVKAEEEIDKILIVYNSENMFGFKDIEDNIDNTGERLTYWDNFGLLSGTVGVLLVLMEYCNIVNAGKIAEWNKIFLLT$","7308 mutC","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).See sequences for strain CH43, also classified as a mutacin I.","modifying enzyme; MutC from strain UA140","Cytoplasm","This sequence corresponds to gi12082660 in GenBank. Nearest neighbor in the NR db is GI:49245082 from S.aureus. Weakly similar to TF1115.This sequence is similar to gi9801999(CH43), gi5918761 (UA787), and very weakly to gi 2853236 (orf1 of T8) and gi4103629 (MutM of T8)","

InterPro
IPR007822
Family

Lanthionine synthetase C-like
PF05147	$\"[38-423]T$	LANC_like

","","","","","","","","","","","","","","Thu May 5 09:06:51 2005","Wed Apr 27 10:11:31 2005","Thu Jul 14 13:41:18 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","No sequences are paralogous to this sequence.","Tue Apr 26 13:32:40 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423","","Wed Apr 27 10:11:31 2005","","3","","","","" "MI0006","7331","7897","567","ATGGAAGAACAAAATATAGAGAAAAAAATTCTCTTGTGCCTAACAGGTTCTGGACCCTTGTTAGGGATAGCTGAATATATTACGTTTTTGACTGTGCGCTTTAAGCATGTTCGAGTTATTATCTCTGATAATGCTGCGAAGATGCTTCCTGTTGCTGCTATTACACAATTGTGTGAGAAAGTGTATACTGATGAAGTTTCCTTTACAGATAAGCAAAAGAGTCACATAGCTTTAACTCGCTGGGCAGACATAACAGTTGTCTTACCTGCTACAGCAAATATAATTGGAAAAGTTGCTAATGGTATTGCAGATAACTTTATGACAACAACTCTTCTTTCTTCTAGCAAGCCAGTTTTAATTTATCCTTGCATGAATAATATTATGTGGGGAAATCCAGTAGTTCAAAAAAATGTTGAAGTTTTATCTGGAACCCAATATAAGGTAATTGTTGGACAAGAATCAGAATCTTTTGAATTAGCCAGTGGAAAGATGAAAAAGAATATTGCAATTCCAAGTTTGGATGAATTGCGACGGGTTGTTTTAGAAAATTTGCAAGAAGAGAGGTAA","","","20851","MEEQNIEKKILLCLTGSGPLLGIAEYITFLTVRFKHVRVIISDNAAKMLPVAAITQLCEKVYTDEVSFTDKQKSHIALTRWADITVVLPATANIIGKVANGIADNFMTTTLLSSSKPVLIYPCMNNIMWGNPVVQKNVEVLSGTQYKVIVGQESESFELASGKMKKNIAIPSLDELRRVVLENLQEER$","7897 mutD","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).LanD is apparently responsible for C-terminal oxidative decarboxylation ((Chen and Caufield (2000))).See sequences for strain CH43, also classified as a mutacin I.","modifying protein; MutD protein from strain UA140","Membrane, Cytoplasm","This sequence corresponds to gi12082661 in GenBank. Nearest neighbor in the NR db is GI:56965319 from B. clausii KSM-K16. Similar to TF0212.This sequence is identical to gi9802000 (CH43) and gi5918762 (UA787).","

InterPro
IPR003382
Domain

Flavoprotein
G3DSA:3.40.50.1950	$\"[7-180]T$	Flavoprotein
PF02441	$\"[8-123]T$	Flavoprotein
SSF52507	$\"[2-186]T$	Flavoprotein

noIPR
unintegrated

unintegrated
PTHR14359	$\"[22-188]T$	PTHR14359
PTHR14359:SF6	$\"[22-188]T$	PTHR14359:SF6

","","","","","","","","","","","","","","Thu May 5 09:07:21 2005","Wed Apr 27 10:13:38 2005","Thu Jul 14 13:43:27 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0983 in strain UA159.","Wed Apr 27 10:27:37 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423","","Wed Apr 27 10:13:38 2005","","3","","","","" "MI0007","7902","9245","1344","ATGAAGAAGAAAGGATTACTAGTAATAATCTTTCTAACTTTCTTTTTCTTTTATCCTAAAGCTAAAGCTGCTGAATATACAATTATATCAAATAATAGTGAACAAACTGTTAATGACTTGAATAATTTAGGAGTTACAGTCAATAGCCATATTGCGGAAATTGGATATATTGAAGCTCAAGGAGATGTTAACATTGATCAGATTGAAAAGCTGTCAAATATTCAAAGTATCCAGAATATGGCTGATACATCACAGAATATCACGACTAGAGTTCCTTCAACATATATTAACCAGACAATACAATTGCCTCAGCTTTTTTCTTATCAGTGGGGTATGCAAAAAATTACTAATAATGGTGTTTCATATTCATTAAATAAAGAAAATCGAAAAAATGTAACAGTTGCTTTAGTTGATTCTGGGATTGATGTAGACCATAATGCTTTTACAGGAATGATTGATAGTCGTTCAAAAAATTTTGTGCCTGCTGGAGGATATGATAATAGTGAAAGCAGTGAAACTGGAAATATTAATGATATTGATGATAAAAAAGGCCATGGAACAGCAGTTGCTGGGCAAATTGCTGCAAATGGTCAAATCTTTGGTGTGTCCCCAGGAACGAACCTTCTTATCTATAGAGTTTTTGGAAAATCAAAATCAAAGGAGTGCTGGATTTTAAAAGCAATTATTGATGCAACAAATAACGGTGCTAATGTTATTAATCTAAGTTTGGGGCAATATATTAAGATTCCTAATGGTGATATTTGGGAGTCTGCCGAAGCATTAGGATATAAGTTTGCCATTGATTATGCCACAAGACATAATGTCATTGTTGTAGCAGCCACAGGTAATGATGGATTAAGTGATGACAACGGAGAGGTTAAAACTTATTATAATAGTCAGCATTCAGGACAAGATATGTCTCAAAATGACACGGTTGAAGATTATCCTTCTGTTTTACCTAATGCTATTGCAGTTGGCTCTTCTGATAATAATAATCAAAGATCATCTTTTAGTAATTACTATAATCAATATCAGGACAATTTTATTTTGGCTCCTGGTGGTGGAACAACTTTACTAGACCAATATGGTCAAGAAGAGTGGTATAATCAGAAACTTTTTATGAAAGAACAAGTCTTATCAACAAGTAATAATGGAAATTATGATTATGCAGATGGTACTTCTATTTCAACAGGAAAAGTTTCTGGAGAGCTTGCAGAAATTATTAGTAACTACCATCTTCAAGGAGATTCTTCAAAAGCTAGAAGTATTCTACTAAATCAAGTTAATTATACTAGTGATGGTTATAAAGAAATAAGCACTTACAAAGCTTTGCGAGGTTACTAA","","","49128","MKKKGLLVIIFLTFFFFYPKAKAAEYTIISNNSEQTVNDLNNLGVTVNSHIAEIGYIEAQGDVNIDQIEKLSNIQSIQNMADTSQNITTRVPSTYINQTIQLPQLFSYQWGMQKITNNGVSYSLNKENRKNVTVALVDSGIDVDHNAFTGMIDSRSKNFVPAGGYDNSESSETGNINDIDDKKGHGTAVAGQIAANGQIFGVSPGTNLLIYRVFGKSKSKECWILKAIIDATNNGANVINLSLGQYIKIPNGDIWESAEALGYKFAIDYATRHNVIVVAATGNDGLSDDNGEVKTYYNSQHSGQDMSQNDTVEDYPSVLPNAIAVGSSDNNNQRSSFSNYYNQYQDNFILAPGGGTTLLDQYGQEEWYNQKLFMKEQVLSTSNNGNYDYADGTSISTGKVSGELAEIISNYHLQGDSSKARSILLNQVNYTSDGYKEISTYKALRGY$","9245 mutP","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).See sequences for strain CH43, also classified as a mutacin I.","subtilisin-like proteinase; MutP protein from strain UA140","Extracellular","This sequence corresponds to gi12082662 in GenBank. Nearest neighbor in the NR db is gi49245080 from Staphylococcus aureus subsp. aureus MSSA476. Weaker similarities to TF2536, TF2765 and other TF sequences..This sequence is similar to gi9802001 (CH43), gi5918763 (UA787).","

InterPro
IPR000209
Domain

Peptidase S8 and S53, subtilisin, kexin, sedolisin
PR00723	$\"[129-148]T$ $\"[181-194]T$ $\"[391-407]T$	SUBTILISIN
PF00082	$\"[111-409]T$	Peptidase_S8
PS00136	$\"[134-145]?$	SUBTILASE_ASP
PS00137	$\"[185-195]T$	SUBTILASE_HIS

InterPro
IPR008357
Family

Peptidase S8, lantibiotic leader peptide processing protein
PR01779	$\"[105-117]T$ $\"[204-219]T$ $\"[256-271]T$ $\"[362-376]T$	LANTIPROCESS

InterPro
IPR015500
Domain

Subtilisin-related serine protease
PTHR10795	$\"[65-285]T$ $\"[307-355]T$ $\"[378-433]T$	SubtilSerProt

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.200	$\"[130-445]T$	G3DSA:3.40.50.200
PTHR10795:SF32	$\"[65-285]T$ $\"[307-355]T$ $\"[378-433]T$	PTHR10795:SF32
SSF52743	$\"[91-432]T$	SSF52743

","","","","","","","","","","","","","","Thu May 5 09:07:59 2005","Thu Sep 28 11:04:23 2006","Thu Jul 14 13:47:11 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","There are no sequences paralogous to this sequence.","Tue Apr 26 13:44:08 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423","","Wed Apr 27 10:14:10 2005","","3","","","","" "MI0008","9246","9746","501","ATGAAGTGGTTAGAAGTTTTGCAAATTAGTAAAAAAGAAAAAATTCTTTATCTTATTGGTTGTATATTTTCAATTATGACAGGCTTAATTACTCTACGAATCACCTACGTACTTAAGAATTTAGTTGACAGCAAATCGTCTTTTAATAATGTGTTCTTGTTTCTTGTTTTGGGATTAGTTCTTTTTATCATAGATGCTGGTTCACAGTATCTAATTTCATTGATTGGTAATCAAGTCGTGTTTAACAGTCGAAATAATATTTGGAAAAAAATTTCTGATTGGACAGATAGTAAAGATGATTCTTCTGAAATGGCAGGCCACCTTATTAATGATAGTGAACTGATAGAAAATTTTATAATTTCTACTATTCCTCAATCATTAAATTCAGTTATTGTTGAATCAGAATCCTTAGTTATGCTATTTGTTATTAATAGTAAAATGTCTTTGGAAGTTATAGGGATTTGCTTGCTTTTATTGTTCATTATGCAACCCTTTTCTAGA","","","18928","MKWLEVLQISKKEKILYLIGCIFSIMTGLITLRITYVLKNLVDSKSSFNNVFLFLVLGLVLFIIDAGSQYLISLIGNQVVFNSRNNIWKKISDWTDSKDDSSEMAGHLINDSELIENFIISTIPQSLNSVIVESESLVMLFVINSKMSLEVIGICLLLLFIMQPFSR","9746 mutT","The MutI operon in S.mutans strain UA140 falls into the larger subclass of lantibiotics designated AI. According to Chen and Caufield (2000), this subclass includes nisin, subtilin, epidermin and pep5. Common to the operons of this class are lanA, the structural gene for the lantibiotic, lanB and lanC, the modifying enzymes, lanP, a protease, and lanT, an ABC transporter that provides secretion of the lantibiotic ((Chen and Caufield, (2000))).See sequences for strain CH43, also classified as a mutacin I.","ABC transporter; MutT protein from strain UA140","Membrane, Cytoplasm","This sequence corresponds to gi12082663 in GenBank. Nearest neighbor in the NR db is GI:42519083 from Lactobacillus johnsonii NCC 533.This sequence is similar to gi9802002 (CH43), gi5918764 (UA787).","

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[18-167]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
PTHR19242	$\"[3-167]T$	PTHR19242
PTHR19242:SF91	$\"[3-167]T$	PTHR19242:SF91
SSF90123	$\"[6-167]T$	SSF90123

","","","","","","","","","","","","","","Thu May 5 09:08:20 2005","Wed Apr 27 10:18:12 2005","Thu May 12 14:08:57 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is weakly paralogous to Smu0825.","Tue Apr 26 13:48:43 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Qi F, Chen P, Caufield PW.The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.Appl Environ Microbiol. 2001 Jan;67(1):15-21.PMID: 11133423","","Wed Apr 27 10:18:12 2005","","3","","","","" "MIII0001","205","1059","855","TTGAAAGTAAATCAATCAATGGAATTAGGTGAACTTTATCGAGAATTAAGAATTGCTAGAGGTTTGAAGATAAAAGATATAGCTTGTAAAAATCTGTCCAAGTCACAACTCTCTAGATTTGAAAATGGACAAACCATGTTGGCAGCTGATAAATTGCTATTAGCTATTTCGGGAATTCATATGAGCTTTTCGGAATTTGGATATGCTTTGAGCCATTATGAGGAGAGTGATTTTTTCAAAAGGGGTCATAAGTTATCAGAATTATATGCCCAGAAAGATATCAAAGGATTAAAAAAGTTATTAGAATTTAATGACAATCATGAGGTATTTGATGTCTACAATCGTTTAAATAAATTGGTTATTCAAGTTACTATTCATTTGCTAGATACTGATTACATAATATCAGATGATGATAAGAATTTTTTAACAACTTATCTATATAATATTGAAGAGTGGACTGAGTATGAACTTTATATCTTTGGGAATACTATGTCTATATTGTCATCTGATGATTTAATTTTTTTGGGAAAAGCTTTTGTAGAACGTGATAAGTTGTATATATCTCTTCCTAGTCATAAGAAAAATGCAGAGTTAACTTTTTTAAATTTAATCTTAATTTTGCTTGAAAGAAAAAAATTATATCAAGCAATCTATTTTGTAGAGAATTTAGAGAAATTATTAAATTACCAAGATATGTTTGCAATAACATTTTTAAAATTTTTAAAAAAAATTATTACTTACTTTCATGATAAGTCAGTAGATATGTCTGAATTAGAACATTATATTAATATAGTTGAAGAAATAAATCCTACGATTGCTTCAATTCTTAAATCTAATTTGAATCAGCTTTTATAA","","","33332","LKVNQSMELGELYRELRIARGLKIKDIACKNLSKSQLSRFENGQTMLAADKLLLAISGIHMSFSEFGYALSHYEESDFFKRGHKLSELYAQKDIKGLKKLLEFNDNHEVFDVYNRLNKLVIQVTIHLLDTDYIISDDDKNFLTTYLYNIEEWTEYELYIFGNTMSILSSDDLIFLGKAFVERDKLYISLPSHKKNAELTFLNLILILLERKKLYQAIYFVENLEKLLNYQDMFAITFLKFLKKIITYFHDKSVDMSELEHYINIVEEINPTIASILKSNLNQLL$","1059 mutR","","transcriptional regulator for the MutIII operon, strain UA787","Cytoplasm","This sequence corresponds to GI:5918757 in GenBank. Nearest neighbor is GI:12082656 from S.mutans strain UA140. Nearest non-mutans neighbor is GI:15900079 from S.pneumoniae.Other similarities are to gi9801995 (CH43), gi4102023 (T8), gi3047245 (JH1005).","

InterPro
IPR001387
Domain

Helix-turn-helix type 3
SM00530	$\"[12-66]T$	HTH_XRE

InterPro
IPR010057
Domain

Transcriptional activator Rgg/GadR/MutR, C-terminal
TIGR01716	$\"[68-284]T$	RGG_Cterm: transcriptional activator, Rgg/G

","","","","","","","","","","","","","","","Thu Apr 28 09:10:37 2005","Thu May 5 11:04:40 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0099 and Smu1371 from strain UA159.","Thu Apr 28 09:10:37 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Gtz F, Entian KD.Analysis of genes involved in the biosynthesis of lantibiotic epidermin.Eur J Biochem. 1992 Feb;204(1):57-68.PMID: 1740156Hillman JD, Novk J, Sagura E, Gutierrez JA, Brooks TA, Crowley PJ, Hess M, Azizi A, Leung K, Cvitkovitch D, Bleiweis AS.Genetic and biochemical analysis of mutacin 1140, a lantibiotic from Streptococcus mutans.Infect Immun. 1998 Jun;66(6):2743-9.PMID: 9596742","Tue May 3 08:31:45 2005","Thu May 5 11:04:40 2005","4","","","","" "MIII0002","1646","1837","192","ATGTCAAACACACAATTATTAGAAGTCCTTGGTACTGAAACTTTTGATGTTCAAGAAGATCTCTTTGCTTTTGATACAACAGATACTACTATTGTGGCAAGCAACGACGATCCAGATACTCGTTTCAAAAGTTGGAGCCTTTGTACGCCTGGTTGTGCAAGGACAGGTAGTTTCAATAGTTACTGTTGCTGA","","","6950","MSNTQLLEVLGTETFDVQEDLFAFDTTDTTIVASNDDPDTRFKSWSLCTPGCARTGSFNSYCC$","1837 mutA","","precursor protein to mutacin III; MutA protein from strain UA787","Extracellular, Periplasm","This sequence corresponds to GI:5918758 in GenBank. Nearest neighbor in the NR db is GI:3047246 from strain 1140. Nearest non-mutans sequence is gi46967 from S epidermis.For other similarities, see gi9801996 (CH43), gi12082657 (UA140), gi12082658 (UA140), gi5918759 (UA787), and gi9801997 (CH43).","

InterPro
IPR006078
Family

Gallidermin
PR00323	$\"[43-52]T$ $\"[53-62]T$	GALLIDERMIN

InterPro
IPR006079
Family

Lantibiotic
PF02052	$\"[12-63]T$	Gallidermin

","","","","","","","","","","","","","","","Thu Apr 28 09:25:55 2005","Thu May 5 11:05:30 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities found to chromosomal genes of UA159.","Thu Apr 28 09:25:55 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390Li S, Liu T, Xiao X, Yang J, Yang D, Zhuang H, Liu Z.Detection of mutA genes in transmitted strains and nontransmitted strains of mutans streptococci.Caries Res. 39(5):417-21.PMID: 16110215","Bekal-Si Ali S, Hurtubise Y, Lavoie MC, LaPointe G.Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes.Gene. 2002 Jan;283(1-2):125-31.PMID: 11867219Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Gtz F, Entian KD.Analysis of genes involved in the biosynthesis of lantibiotic epidermin.Eur J Biochem. 1992 Feb;204(1):57-68.PMID: 1740156Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","Thu Apr 26 09:27:29 2007","Thu May 5 11:05:30 2005","4","","","","" "MIII0003","1904","2098","195","ATGTTAAATACACAATTATTAGAAGTCCTTGGTACTAAAACTTTTGATGTTCAAGAAGATTTATTTGAGTTTAATATAACAGATACTATTGTACTGCAGGCTAGTGATAGTCCAGATACTCATAGTAAAGTGGGTAGTTTCAATATCTGCCCTCCTCGAAAGATCTCCGTCAGTTTCAATAGTTACTGTTGTTAA","","","7142","MLNTQLLEVLGTKTFDVQEDLFEFNITDTIVLQASDSPDTHSKVGSFNICPPRKISVSFNSYCC$","2098 mutA'","","mutA' from strain UA787","Extracellular, Cytoplasm","This sequence corresponds to GI:5918759 in GenBank. Its nearest neighbor in the NR db is GI:12082658 from strain UA140. There are no nearest non-mutans sequences in the NR database.For other similarities, see gi9801997 (CH43), gi3047247 (JH1005), gi3047246 (JH1005), gi5918758 (UA787), gi9801996 (CH43), and gi12082657 (UA140). ","

InterPro
IPR006079
Family

Lantibiotic
PF02052	$\"[12-64]T$	Gallidermin

","","","","","","","","","","","","","Thu May 5 11:06:10 2005","","Thu May 5 11:06:10 2005","Thu May 5 11:06:10 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","The are no similarities to the chromosomal genes of UA159.","Thu Apr 28 09:36:10 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390","Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Gtz F, Entian KD.Analysis of genes involved in the biosynthesis of lantibiotic epidermin.Eur J Biochem. 1992 Feb;204(1):57-68.PMID: 1740156Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","Tue May 3 08:30:27 2005","Thu May 5 08:29:39 2005","4","","","","" "MIII0004","2253","5225","2973","ATGAACGATTTTCAATTTCAAGATTATTTTATGTACAGAAAACCATTAGGCAACTTTTCTAATTTTTTTAGTATAACTGATACGATGGATCCCATTGAGTTACTACATAGTGATCCGATATTTGCTGAAGGAGTATATTTGGCCTCTTCATCTCTTAGAGCAGCCATAAATAAACTTAAGAATCATACTGCGAGTACTAAGGATAAAAAGAATGCAAGAGAGACTATTTTTCAATACTATGCCCGTTATAACACGAGATCAACTCCGTTTGGCTTGTTTTCGTCCATCGGAGTAGGTGCTTTTTCGGCTTACCTTAAAAAAGAAAAGTCTCGTTATGAAAAATCTATTAATATTGATCTTTTTTGGGCTTATAAAGTAGCAGATAAACTAGAAAGTATGCCTGAAATTTTAAATACTTTAAAAGTAGTTGCTAATAATGCTTTGCAAAAGTCAGATAATTTTTGGCTTTTGGATACGCGAAGTCATTTTGGTCTTATGAATTCACGTTCTGATATTCATGAGGACATCACAGTTAAATCTAATCAGCTTATAGATTACGTTATTAATTGTGCAGAACAACCAATTTGTTACCCAACATTAGTTGATAATATTGCCGAGAAATTTTCTCAGTCTAGTGATGGTGTAAAAAAATATTTACAAAAATTAATCAAAGAAGAGTTTTTGATCACTGAGTTAAAATTTAGTTTGATTGAAGACAATCCTTTGGATTGGTTTATTAATATCTTAGAAAGAACTCAAAATAACCTAGAATTACTTGAAAAGTTGACTGAGATAAAGGCAATGATTCAGGACTATACTGACTGTGACATTGGTGAGGGCAACAATTTGATTTTAGCTTTAGAAAATAAGATGAGCCAAATAGCAGAAACTAATGCATATTTGCGGGTTGATCTTTATGATCATGCAGAGTTGGAGTTATCTCATCATATCAAGGATTCTCTTCAGAATATTTTAAAAGTACTAAGTTCTTTTTCACCAGGTATTAATAGTCGGAAAGAAATTAGAAATTACCATGAGAAATTTATTTCCAGATATGGATATGAACAGTTAGTACCTCTTCAATTACTTTTGAATTCTACTAGTGGACTTGGCTTTCCAAAAGGGTATAGTCAGACAAAAGATTTTAAACAAAATAATGGAGATAGTCGGAATCAAAAAATAACAGAATTTTTGCAGAGAAAATTTGAAAAATCTTTAAGAGATGGTAAAGAAATTATTCTGAATGATGATGATTTAAAAGATCTAGATTTTGATAAGGAACAGCAGATATCAGGGGAACTATACTGTTTCTATGATTTTAAAAATAGAAAATTGGAGGTTAGTGGTTTAGGTGTTTCACCGATGATTGGAGATACCTTCGGACGTTTTCATGCTAAATTGCCGAATACGATAATCACAGAAAATGTAAATAAAACGAAAGAAATTTTTGCTAAAGCCTATCCTAATACTATTATTACTCAATTAAATGAAGTGCCATATTTTGGGAGGAGTGGTAATGTTATGGTCAGTAACAGTCTTAAAAGCCATCAGTTGGAGTTGAGAAACTATACTTCAAAAAAAGATATGAGTATCAATGATATTTATGTAGGTGCAACCAGTGAGGAATTATACTTTTATTCTAAAAAATATGGAAAAAGAGTTATTTTTATAATGAATAATATGTTTAATTATATAAATGGTTCCAAACTTTTACGTTTTTTACTAGAAGTTTCAAATTCTGACTTTCAAAATATTACTCCGATTATGTTTGATAATCTGGATTCTTATAATCATGTGCCTACTATCATTTATAAAGACATTATTATTAAACCAGAAACATGGAATATTAGAAAATCTGAAGTTAAGACTTTAGATTCTCTCAAAAATTGGCTATCTGATAATGATGTTCCATCTCTTGTGCGGATGAAATATACTGATCAAATTATTTACTTGGATTTGAGTCGGACTATTGATTTAACTATGTTATTTCGGAGTATTAAAAAACACAGTTTTATACAATTGTTAGCTACTCATTCCGAATTTGTAAACGATACGAAGATTTTGGAGCTAGTTGTGCCTTTTACAAGGAGTGATGTCAATGCTCGCCAGATTTATCATTATGCCCAGAATATTTATACTTTGGAGGATTCAGATAGTAAAGAAAAATATTTTTACGTTAAAATTTATGTTAACAAACAACGACAAACTTCTTTCTTACAAAAAGAATATCCTTTATTATTAAACTATTTGAAACTCCCTGAAAATTTGCAATGGTTCTATATTAGATATGAAGATGATGAAAAAGACAGCATACGTCTCAGAATCAGATATGTAGAAGATAAACAATTAGTTCAACTTTATTCACGCTTTATAGAGTGGGCGACAGAAGCACGGAAAAATATACAAATTTTAGGTTATGAAATTAGTGAATACATCCCTGAATCAGCAAGATATGGAGGAAAAAAATATTCCACAATTATCCATTCTTTTTTCTATTATGATAGTATTTTGAGTTTACTTTTACAAAAGAAAACAGATCAAGCTATTGAAGTGAGAACTTCTCTCAGTATTATTCGCATGTTTTTAATGATGAAATTAAACTTGCAAGATCAACAGGAACTCATGAAAAATTTGTTTGATGGAGAACATAAACTTAAATATGAAAAGGAATATCATAATTCAATAAGTTTATTACTTGATAGTTTATGTACAAGAAATCAGATAGATGAAGCTGATACTTTCTGTGTAATGAATATGAAAATAATCACTGAAGAAGTTAGTTCAGTTCTTAAACAAGAGGACTTAACAACAGATTGGCAGAGAATTCTGGGAAGTCTTATTCATATGCGATGTAATCGAGTATATGGAATTAATAGTGAGTTAGAAAGAAAAACAATGTTTATTGTTGACAAAGTTGTTAATTCAAAAAGATATACAGATATGTTTTTGGAGGTGGATAATGAGACAAAGTAA","","","116160","MNDFQFQDYFMYRKPLGNFSNFFSITDTMDPIELLHSDPIFAEGVYLASSSLRAAINKLKNHTASTKDKKNARETIFQYYARYNTRSTPFGLFSSIGVGAFSAYLKKEKSRYEKSINIDLFWAYKVADKLESMPEILNTLKVVANNALQKSDNFWLLDTRSHFGLMNSRSDIHEDITVKSNQLIDYVINCAEQPICYPTLVDNIAEKFSQSSDGVKKYLQKLIKEEFLITELKFSLIEDNPLDWFINILERTQNNLELLEKLTEIKAMIQDYTDCDIGEGNNLILALENKMSQIAETNAYLRVDLYDHAELELSHHIKDSLQNILKVLSSFSPGINSRKEIRNYHEKFISRYGYEQLVPLQLLLNSTSGLGFPKGYSQTKDFKQNNGDSRNQKITEFLQRKFEKSLRDGKEIILNDDDLKDLDFDKEQQISGELYCFYDFKNRKLEVSGLGVSPMIGDTFGRFHAKLPNTIITENVNKTKEIFAKAYPNTIITQLNEVPYFGRSGNVMVSNSLKSHQLELRNYTSKKDMSINDIYVGATSEELYFYSKKYGKRVIFIMNNMFNYINGSKLLRFLLEVSNSDFQNITPIMFDNLDSYNHVPTIIYKDIIIKPETWNIRKSEVKTLDSLKNWLSDNDVPSLVRMKYTDQIIYLDLSRTIDLTMLFRSIKKHSFIQLLATHSEFVNDTKILELVVPFTRSDVNARQIYHYAQNIYTLEDSDSKEKYFYVKIYVNKQRQTSFLQKEYPLLLNYLKLPENLQWFYIRYEDDEKDSIRLRIRYVEDKQLVQLYSRFIEWATEARKNIQILGYEISEYIPESARYGGKKYSTIIHSFFYYDSILSLLLQKKTDQAIEVRTSLSIIRMFLMMKLNLQDQQELMKNLFDGEHKLKYEKEYHNSISLLLDSLCTRNQIDEADTFCVMNMKIITEEVSSVLKQEDLTTDWQRILGSLIHMRCNRVYGINSELERKTMFIVDKVVNSKRYTDMFLEVDNETK$","5225 mutB","","mutB modifying enzyme from strain UA787","Cytoplasm","This sequence corresponds to gi5918760 from GenBank. Nearest neighbors in the NR are gi12082659 from UA140 and GI:9801998 from strain CH43. Nearest non-mutans is GI:581648 from S.epidermis.See also gi3047248 from strain 1140.Similar to Str0098, a predicted lantibiotic synthesis protein.","

InterPro
IPR006826
Domain

Lantibiotic dehydratase, N-terminal
PF04737	$\"[21-161]T$	Lant_dehyd_N

InterPro
IPR006827
Domain

Lantibiotic dehydratase, C-terminal
PF04738	$\"[195-675]T$	Lant_dehyd_C

","","","","","","","","","","","","","","","Tue May 3 08:10:02 2005","Thu Mar 1 14:46:33 2007","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities to the chromosomal genes of UA159 were found.","Thu Apr 28 09:50:11 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390","Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Gtz F, Entian KD.Analysis of genes involved in the biosynthesis of lantibiotic epidermin.Eur J Biochem. 1992 Feb;204(1):57-68.PMID: 1740156Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","Tue May 3 08:10:02 2005","Thu May 5 08:31:56 2005","4","","","","" "MIII0005","5212","6486","1275","ATGAGACAAAGTAAACGTGTCGAAAAAATTAAAAATATTCTAACAGAGCAAACTTATTTATTTGATTATCAAGAGGTATTAAAAAAAATCAGTCAAGTAAAACAAACAGATTTTTGGAATTTACTTTCTTTGTCTTCGGGAATAACTTCTTTATTAATCTTTTATCAAGAGTATGAGAATTTAGAAGGAGTAAACTTAAAGCCGCAAAAGCAGTCATTGATCGGACTTATAAGTTATTATATTAATCAAATAGCAGATAAATCCTCTTTATTTGATGGTTTAGCTGGGGTAGGTTTTGCTATTAATTATGTCTCTAATAACGGTAAATATTATCAAAAACTTCTTAATCAAATTGACAGTAAAATTTGTCAGAACGTTAAGCGGAACCTTGCTGATTGTAATAGTGAAGAGTATACAAATCCTATGAATTATGATGTAATTTCTGGAAATGCTGGAGTAGCTCGTTATCTGATGGAAAGAGAATCCTCTGAAGATTGGCGAATTGTTGAAATGATTTTAGAAGTATTTTATAAAGCTTTGGAACAAGGCTGGCGAGTGCAACCAAAATATCAATTTTTAGAATCTGAAAAGCAATATTATTTAAAGGGAAATATAAACTTTGGTTTAGCTCATGGATTATTAGGTCCTACAACAATTATGTCTCTTTATCAGCAGAGGTACCCACAGAACACAAGAAATGCTGAGAAACTTCAGGAGACTTATCATTTTATAAAAAGATATGCTCAACTAAGAGATGAGGGGCTACGATGGCCAATACGATATGATTTACTTCGTAAAGAGGGTTCTTTTATATTACGAAATGGCTGGTGTTATGGAGATAATGGCATTTATAGTACACTTTTTCTTATGGGAAAAGTACTCTCAAATCAGAAGATTTGTGAAACTGCTCAGAAAGTTATACCATCCATCATAAAAGATGATTATGAGAAAATGGAAAGTCCAACATTTTGTCATGGGTTTGCTGGAAAAGCAAATTTCTTTCTTCTGCAATATCAAAGAACTAAAGAATCAATATTTTTAGTTAAAGCAGAAGAAGAAATTGATAAAATATTAATTGTGTACAATTCTGAAAATATGTTTGGATTTAAAGATATAGAAGATAATATTGATAATACTGAAGAGAGATTAACTTATTGGGATAATTTTGGTCTTCTTAGTGGAACTGTTGGTGTTCTATTAGTTTTGATGGAATATTGTAATATTGTAAATGCTGGAAAAGTTTCAGAGTGGAATAAAATTTTTCTTTTAACTTAA","","","49451","MRQSKRVEKIKNILTEQTYLFDYQEVLKKISQVKQTDFWNLLSLSSGITSLLIFYQEYENLEGVNLKPQKQSLIGLISYYINQIADKSSLFDGLAGVGFAINYVSNNGKYYQKLLNQIDSKICQNVKRNLADCNSEEYTNPMNYDVISGNAGVARYLMERESSEDWRIVEMILEVFYKALEQGWRVQPKYQFLESEKQYYLKGNINFGLAHGLLGPTTIMSLYQQRYPQNTRNAEKLQETYHFIKRYAQLRDEGLRWPIRYDLLRKEGSFILRNGWCYGDNGIYSTLFLMGKVLSNQKICETAQKVIPSIIKDDYEKMESPTFCHGFAGKANFFLLQYQRTKESIFLVKAEEEIDKILIVYNSENMFGFKDIEDNIDNTEERLTYWDNFGLLSGTVGVLLVLMEYCNIVNAGKVSEWNKIFLLT$","6486 mutC","","modifying enzyme for premutacin III from strain UA787","Cytoplasm","This sequence corresponds to gi5918761 from GenBank. Nearest non-mutans neighbor in the NR db is GI:49245082 from S.aureus.Similar to Str0099, a predicted lantibiotic synthesis protein.For other similarities, see gi9801999 (CH43), gi12082660 (UA140), gi2853236 (weak from T8 ), and gi4103629 (weak from T8).","

InterPro
IPR007822
Family

Lanthionine synthetase C-like
PF05147	$\"[38-422]T$	LANC_like

","","","","","","","","","","","","","","","Tue May 3 20:44:44 2005","Thu Mar 1 14:48:22 2007","","","","yes","Fri Feb 20 15:41:32 MST 1998","No sequences are paralogous to this sequence.","Tue May 3 08:16:55 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390","Schnell N, Engelke G, Augustin J, Rosenstein R, Ungermann V, Gtz F, Entian KD.Analysis of genes involved in the biosynthesis of lantibiotic epidermin.Eur J Biochem. 1992 Feb;204(1):57-68.PMID: 1740156Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","Tue May 3 08:27:40 2005","Tue May 3 20:44:44 2005","4","","","","" "MIII0006","6509","7075","567","ATGGAAGAACAAAATACAGAGAAAAAAATTCTCTTGTGTCTAACAGGTTCTGGAGCCTTGTTAGGGATAACTGAATATATTACGTTTTTGACTGTGCGCTTTAAGCATGTTCGAGTTATTGTCTCTGATAATGCTGCGAAGATGCTTCCCGTTGCTGCTATTACACAATTGTGTGAGAAAGTGTATACTGATGAAGTTTCCTTTACAGATAAGCAAAAGAATCACATAGCTTTAACTCGCTGGGCAGACATAACAGTTGTCTTACCTGCTACAGCAAATATAATTGGAAAAGTTGCTAATGGTATTGCAGATAACTTTATGACAACAACTCTTCTTTCTTCTAGCAAGCCAGTTTTAATTTATCCTTGCATGAATAATATTATGTGGGAAAATCCAGTAGTTCAAAAAAATGTTGAAGTTTTATCTGGAACCCAATATAAGGTAATTGTTGGACAAGAATCAGAATCTTTTGAATTAGCCAGTGGAAAGATGAAAAAGAATATTGCAATTCCAAGTTTGGATGAATTGCAACGAGTTGTTTTAGAAAATTTACAAGAAGAGAGGTAA","","","20900","MEEQNTEKKILLCLTGSGALLGITEYITFLTVRFKHVRVIVSDNAAKMLPVAAITQLCEKVYTDEVSFTDKQKNHIALTRWADITVVLPATANIIGKVANGIADNFMTTTLLSSSKPVLIYPCMNNIMWENPVVQKNVEVLSGTQYKVIVGQESESFELASGKMKKNIAIPSLDELQRVVLENLQEER$","7075 mutD","This enzyme is thought to be involved in C-terminal oxidative decarboxylation of the pre mutacin.","modifying enzyme for premutacin III from strain UA787","Cytoplasm, Membrane","This sequence corresponds to gi5918762 in GenBank. Nearest non-mutans neighbor in the NR db is GI:56965319 from Bacillus clausii.For other similarities see gi9802000 (CH43) and gi12082661(UA140).","

InterPro
IPR003382
Domain

Flavoprotein
G3DSA:3.40.50.1950	$\"[7-180]T$	Flavoprotein
PF02441	$\"[8-123]T$	Flavoprotein
SSF52507	$\"[2-186]T$	Flavoprotein

noIPR
unintegrated

unintegrated
PTHR14359	$\"[14-188]T$	PTHR14359
PTHR14359:SF6	$\"[14-188]T$	PTHR14359:SF6

","","","","","","","","","","","","","","Tue May 3 10:59:24 2005","Tue May 3 20:45:17 2005","Thu May 5 11:13:02 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0983, a predicted DNA/pantothenate metabolism flavoprotein.","Tue May 3 10:59:24 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390","","Tue May 3 20:45:17 2005","","4","","","","" "MIII0007","7080","8423","1344","ATGAAGAAGAAAGGATTACTAGTAATAATCTTTCTAACTTTCTTTTTCTTTTATCCTAAAGCTAAAGCTGCTGAATATACAATTATATCAAATAATAGTGAACAAACTGTTAATGGCTTGAATAATTTAGGAGTTACAGTCAATAGCCATATTGCGGAAATTGGATATATTGAAGCTCAAGGAGATGTTAACATTGATCAGATTAAAAAGCTGTCAAATATTAAAAGTATCCAGAATATGGCTGATACATCACAGAATATCACGACTAGAGTTCCTTCAACATATATTAACCAGACAATACAATTGCCTCAGCTTTTTTCTTATCAGTGGGATATGCAAAAAATTACTAATAATGGTGTTTCATATTCATTAAATAAAGAAAATCGAAAAAATGTAACAGTTGCTTTAGTTGATTCTGGGATTGATGTAGACCATAATGCTTTTACAGGAATGATTGATAGTCGTTCAAAAAATTTTGTGCCTGCTGGAGGATATGATAATAGTGAAAGCAGTGAAACTGGAAGTATTAATGATATTGATGATAAAAAAGGCCATGGAACAGCAGTTGCTGGGCAAATTGCTGCAAATGGTCAAATCTTTGGTGTGTCCCCAGGAACGAACCTTCTTGTCTATAGAGTTTTTGGAAAATCAAAATCAAAGGAGTGCTGGATTTTAAAAGCAATTATTGATGCAACAAATAATGGTGCTAATGTTATTAATCTAAGTTTGGGGCAATATATTAAGATTCCTAATGGTGATATTTGGGAGTCTGCCGAAGCATTAAGATATAAGTTTGCCATTGATTATGCCACAAGACATAATGTCATTGTTGTAGCAGCCACAGGTAATGATGGATTAAGTGATGACAACGGAGAGGTTAAAACTTATTATAATAGTCAGCATTCAGGACAAGATATGTCTCAAAATGACACGGTTGAAGATTATCCTTCTGTTTTACCTAATGCTATTGCAGTTGGCTCTTCTGATAATAATAATCAAAGATCATCTTTTAGTAATTACTATAATCAATACCAGGACAATTTTATTTTGGCTCCTGGTGGTGGAACACCTTTACTAGACCAATATGGTCAAGAAGAGTGGTATAATCAGAAGCTTTTTATGAAAGAACAAGTATTATCAACAAGTAATAATGGAAATTATGATTATGCAGATGGTACTTCTATTTCAACAGGAAAAGTTTCTGGAGAGCTTGCAGAAATTATTAGTAACTACCATCTTCAAGGAGACTCTTCAAAAGCTAGAAGTATTCTACTAAATCAAGTTAATTATACTAGTGATGGTTATAAAGAAATAAGCACTTACAAAGCTTTGCGAGGTTACTAA","","","49181","MKKKGLLVIIFLTFFFFYPKAKAAEYTIISNNSEQTVNGLNNLGVTVNSHIAEIGYIEAQGDVNIDQIKKLSNIKSIQNMADTSQNITTRVPSTYINQTIQLPQLFSYQWDMQKITNNGVSYSLNKENRKNVTVALVDSGIDVDHNAFTGMIDSRSKNFVPAGGYDNSESSETGSINDIDDKKGHGTAVAGQIAANGQIFGVSPGTNLLVYRVFGKSKSKECWILKAIIDATNNGANVINLSLGQYIKIPNGDIWESAEALRYKFAIDYATRHNVIVVAATGNDGLSDDNGEVKTYYNSQHSGQDMSQNDTVEDYPSVLPNAIAVGSSDNNNQRSSFSNYYNQYQDNFILAPGGGTPLLDQYGQEEWYNQKLFMKEQVLSTSNNGNYDYADGTSISTGKVSGELAEIISNYHLQGDSSKARSILLNQVNYTSDGYKEISTYKALRGY$","8423 mutP","","serine protease from strain UA787","Extracellular","This sequence corresponds to GI:5918763 in GenBank. Nearest non-mutans neighbor in the NR db is GI:57650609 from S.aureus.For other similarities, see gi9802001 (CH43) and gi12082662 (UA140).","

InterPro
IPR000209
Domain

Peptidase S8 and S53, subtilisin, kexin, sedolisin
PR00723	$\"[129-148]T$ $\"[181-194]T$ $\"[391-407]T$	SUBTILISIN
PF00082	$\"[111-409]T$	Peptidase_S8
PS00136	$\"[134-145]?$	SUBTILASE_ASP
PS00137	$\"[185-195]T$	SUBTILASE_HIS

InterPro
IPR008357
Family

Peptidase S8, lantibiotic leader peptide processing protein
PR01779	$\"[105-117]T$ $\"[204-219]T$ $\"[256-271]T$ $\"[362-376]T$	LANTIPROCESS

InterPro
IPR015500
Domain

Subtilisin-related serine protease
PTHR10795	$\"[65-285]T$ $\"[307-355]T$ $\"[378-433]T$	SubtilSerProt

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.200	$\"[130-445]T$	G3DSA:3.40.50.200
PTHR10795:SF32	$\"[65-285]T$ $\"[307-355]T$ $\"[378-433]T$	PTHR10795:SF32
SSF52743	$\"[91-432]T$	SSF52743

","","","","","","","","","","","","","","","Tue May 3 20:45:54 2005","Thu May 5 11:14:12 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","No sequences are paralogous to this sequence.","Tue May 3 11:04:59 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390","","Tue May 3 20:45:54 2005","","4","","","","" "MIII0008","8424","10049","1626","ATGAAGTGGTTAGAAGTTTTGCAGATTAGTAAAAAAGAAAAAATTCTTTATCTTATTGGTTGTATATTTTCAATTATGACAGGCTTAATTACTCTACGAATCACCTACTTACTTAAGAATTTAGTTGACAGCAAATCGTCTTTTAATAATTTGTTCTTGTTTCTTGTTTTGGGATTAGTTCTTTTTATCATAGATGCTGGTTCACAGTATCTAATTTCATTGATTGGTAATCAAGTAGTGTTTAACAGTCGAAATAATATTTGGAAAAAAATTTCTGATTGGACAGATAGTAAAGATGATTCTTCTGAAATGGCAGGCCACCTTATTAATGATAGTGAACTGATAGAAAATTTTATAATTTCTACTATTCCTCAATCAATAAATTCAGTTATTGTTGGATCAGGATCCTTAGTTATGCTATTTGTTATTAATAGTAAAATGTCTTTAGAAGTTATAGGGATTTGCTTTCTTTTATTGTTCATTATGCAACCCTTTTCTAGAATATTAAGCAAAATAAGTAAAAGAATCCAGGAAGACAAAGCTGAACTTATTAATATTGCCTCACAGTTGAGAGGACAAGTCAAAACAATAAAAAGCTATAATGCTCAAGATTATGCCTTTCAAAAATTTGATGAGCAAAATCGCCAATTATTTCAAGATATCTTAAATAGAATAAAAATTTTTAGCATTTACTCTCCTTTTTTAAATATCTTAATTCTTTTTATGATTATAATTGTTGTTTGGCTAGGAAATACAGAAGTACGTTCAGGAAATCTCACTGTAGGTTCAGCAACTATTTTTGTTGTTTATATGACACAATTAATTAATCCAATTATGCAATTATCACAATTAGTTGCTCATATGGGGATGCTTAATGGCGGCGTGGAACGTCTTTTGGAGTATAATCAAGCTATTCCAGAAAAAAATGGAATCAAGAAAATTGATGAAATAATTAATATCGCGTTTGATAATGTTTCATTTGCTTATGATAACCAAGAAAATATTATTGAAAATGTGAATTTAACTTTTCAAAAAGGTACTTATATTTCCATTGTTGGTGAAAGTGGAGTTGGGAAATCAACCTTACTTGATCTTTTAGAACATAATTATGTACCATCAAAAGGACGAATCTTAATAAACGGAATAGATTTAGAAGAATTGAATATTAAGACTTTGCGAAATAAGATAAGCTATGTATCTCAAGAACCAACAATTCTTTCTGGGACAATTCGTGAACTATTAGACTTTAATCAGCAACAGCATACAGAAACTAGTCTTTGGAATGTTCTTGATACTGTAGAATTATCAGAACTTATTAGAAATTTACCGCGAAAATTAGATTCTAAGGTTGATGAATATGGTGGTAACCTCTCTGGAGGTCAGATGCAACGGATCTCACTTGCAAGAGGATTACTGAAAGCAGGAGATGTTTTATTATTAGATGAATCTTTTGCCAATATTGATGAAGAGACTTGTCTTAAAATAAAATTAAAAATTGCTGCTTATGCTGAATCACACAAGCAAATTGTTATTGAAGTTATTCATAATCTAAATAGAATAACTCCCAGTAGTATCGTTTACCGATTGGCTGATAAAAAACTAGAAATTTTGAGGAGCGGATTCTAA","","","61192","MKWLEVLQISKKEKILYLIGCIFSIMTGLITLRITYLLKNLVDSKSSFNNLFLFLVLGLVLFIIDAGSQYLISLIGNQVVFNSRNNIWKKISDWTDSKDDSSEMAGHLINDSELIENFIISTIPQSINSVIVGSGSLVMLFVINSKMSLEVIGICFLLLFIMQPFSRILSKISKRIQEDKAELINIASQLRGQVKTIKSYNAQDYAFQKFDEQNRQLFQDILNRIKIFSIYSPFLNILILFMIIIVVWLGNTEVRSGNLTVGSATIFVVYMTQLINPIMQLSQLVAHMGMLNGGVERLLEYNQAIPEKNGIKKIDEIINIAFDNVSFAYDNQENIIENVNLTFQKGTYISIVGESGVGKSTLLDLLEHNYVPSKGRILINGIDLEELNIKTLRNKISYVSQEPTILSGTIRELLDFNQQQHTETSLWNVLDTVELSELIRNLPRKLDSKVDEYGGNLSGGQMQRISLARGLLKAGDVLLLDESFANIDEETCLKIKLKIAAYAESHKQIVIEVIHNLNRITPSSIVYRLADKKLEILRSGF$","10049 mutT","","ABC transporter, ATP binding protein from strain UA787","Membrane, Cytoplasm","This sequence corresponds to GI:5918764 in GenBank. Nearest non-mutans neighbor in the NR db is GI:28379046 from Lactobacillus plantarum WCFS1.For other similarities, see gi9802002(CH43), gi12082663(UA140), gi55847611 (GS5) , gi4103630 (T8), gi4098078 (T8), gi9802355 (CH43), gi55847608(GS5), gi4322367 (T8), gi9802352 (CH43), gi9802003 (CH43) and gi4103631 (T8).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[10-278]T$	ABC_membrane

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[456-491]T$	ABC_transporter
PF00005	$\"[346-540]T$	ABC_tran
PS00211	$\"[457-471]T$	ABC_TRANSPORTER_1
PS50893	$\"[320-541]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[345-540]T$	AAA

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[18-290]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[285-534]T$	G3DSA:3.40.50.300
PTHR19242	$\"[3-491]T$	PTHR19242
PTHR19242:SF91	$\"[3-491]T$	PTHR19242:SF91
SSF52540	$\"[320-534]T$	SSF52540
SSF90123	$\"[6-469]T$	SSF90123

","","","","","","","","","","","","","","","Thu May 5 08:49:44 2005","Thu May 5 08:49:44 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to many ABC-related ATP-binding proteins in Smu, a few of which are Smu0824, Smu0825, Smu0837, Smu0987, Smu0475.","Tue May 3 11:12:31 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification of mutacin III from group III Streptococcus mutans UA787 and genetic analyses of mutacin III biosynthesis genes.Appl Environ Microbiol. 1999 Sep;65(9):3880-7.PMID: 10473390","","Tue May 3 20:46:38 2005","","4","","","","" "MI0011","1472","2212","741","atgattgatttattaaaagcagaaaatgtaaaataccgtcatacttttttaccatggttacacctgattttacctgttactacagctattgttgttattgtttatgggctaatgacgccgactcactcttgggctgatattactggtggttacttagaactattgggtataagttttccaattgtcattgctgttatttgtgggaaatcagttggactagaagtagaggctggtcaatttcaagttatgttagcaattaagcaaaggaacttgatattttgtatcaagttattgaatttgctcattttagaacttttttcaactctattagctataggaatttatggattaatttatcaattaagtaataaacatttgatattttatggatatgctgtaattttactaacagcttcaatgctcattctttatctgattcacttagttgtagtatttttgtttggcaatagtgctaatattgggttggggattgctgaatctttactatctgctttgctcttgacaggtttaggagatggtatctggcaatttattccttgtgcttggggtactcgcctaatgggtaccttaataaatctgtggtattactctgggcacagcttattttttaagcaacagcttttaatttggctggaagtcgcagttccactaactttaatggctttaatccttagtataatttggttcgacagatggcaaggacgtagcagtgatgaataa","","","27556","MIDLLKAENVKYRHTFLPWLHLILPVTTAIVVIVYGLMTPTHSWADITGGYLELLGISFPIVIAVICGKSVGLEVEAGQFQVMLAIKQRNLIFCIKLLNLLILELFSTLLAIGIYGLIYQLSNKHLIFYGYAVILLTASMLILYLIHLVVVFLFGNSANIGLGIAESLLSALLLTGLGDGIWQFIPCAWGTRLMGTLINLWYYSGHSLFFKQQLLIWLEVAVPLTLMALILSIIWFDRWQGRSSDE$","2212 mutG ABC transporter; may be involved with immunity","","MutG protein from strain CH43; ABC permease","Membrane, Cytoplasm","This sequence corresponds to gi9802354 in GenBank. Nearest non-mutans neighbor is GI:49186615 from Bacillis anthracis Sterne.","

noIPR
unintegrated

unintegrated
signalp	$\"[1-29]?$	signal-peptide
tmhmm	$\"[15-37]?$ $\"[47-67]?$ $\"[97-117]?$ $\"[127-147]?$ $\"[152-174]?$ $\"[184-204]?$ $\"[214-236]?$	transmembrane_regions

","","","","","","","","","","","","","","","Thu May 5 20:35:54 2005","Thu May 12 14:12:26 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0599 from the UA159 chromosome.","Thu May 5 20:35:54 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","","Thu May 5 20:35:54 2005","","5","","","","" "MI0012","2236","2976","741","atgacctatattggtgttagtcatctcaaaaaggtgtataaaactcaggaaggcctcactaacgaagcgttaaaagatattacgttctcagttcaagaaggggaatttattgctattatgggtgaatctggctcagggaagtcaactctccttaatatcctagcttgtatggattatccaagtagtggtcatatcatcttcaataactatcaattagagaaagttaaagatgaagaggctgctgtttttagaagtcggcatattggttttatttttcaaaatttcaatcttttaaatatcttcaataataaagacaatctgttgataccagttattatttcgggaagtaaggtgaattcctatgaaaaacgattacgtgatttagctgctgttgttggtatagaatctttgctatctaaatatccttatgaattatctggaggtcaacaacaaaggttagctattgccagagctttaattatgaatccagacttgatattggccgatgagccaacaggacaattggactctaagacttctcagcgaatcttgaatttgttgtctaacatcaacgctaaacgaaagacaattctaatggtgactcatagtcctaaagctgctagttatgcaaaccgagttctttttatcaaggatggtgttattttcaatcaacttgttcgtgggtgtaaatccagggaaggctttttagatcaaattattatggctcaggccagtctgtag","","","27402","MTYIGVSHLKKVYKTQEGLTNEALKDITFSVQEGEFIAIMGESGSGKSTLLNILACMDYPSSGHIIFNNYQLEKVKDEEAAVFRSRHIGFIFQNFNLLNIFNNKDNLLIPVIISGSKVNSYEKRLRDLAAVVGIESLLSKYPYELSGGQQQRLAIARALIMNPDLILADEPTGQLDSKTSQRILNLLSNINAKRKTILMVTHSPKAASYANRVLFIKDGVIFNQLVRGCKSREGFLDQIIMAQASL$","2976 OrfX ABC transporter","","OrfX from strain CH43; ABC element, ATP binding","Membrane, Cytoplasm","This sequence corresponds to gi|9802355 in GenBank. It is similar to gi|4098078, gi|4103630, gi|9802002 and other mutT sequences involved in ABC ATP binding.The nearest non-mutans neighbor is GI:23112719 from Desulfitobacterium hafniense DCB-2.","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[144-187]T$	ABC_transporter
PF00005	$\"[34-219]T$	ABC_tran
PS00211	$\"[145-159]T$	ABC_TRANSPORTER_1
PS50893	$\"[7-243]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[33-220]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[1-222]T$	G3DSA:3.40.50.300
PTHR19222	$\"[4-246]T$	PTHR19222
PTHR19222:SF32	$\"[4-246]T$	PTHR19222:SF32
SSF52540	$\"[4-221]T$	SSF52540

","","","","","","","","","","","","","","","Thu May 5 20:42:03 2005","Thu May 5 20:42:03 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0916, Smu0786, Smu1288 and several other chromosomal genes from strain UA159.","Thu May 5 20:42:03 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","","Thu May 5 20:42:03 2005","","5","","","","" "MI0013","2992","4914","1923","atgtttttacccaaaatttcctttcataatcttattgtaaataaatcattaaccttaccttattttgctattatgaccatttttagtggttttaactatgttttgattaattttttaaccaaccctagtttttataacattccaacagctaggatactgattgatattcttatttttggttttatcttaatttcattactgatgttgctttatggtcgctatgccaatcgttttataagtgatgagcgtaatagtaatatgggaatttttctcatgttgggaatggggaaaaagcaattattaaaaataatctatttggaaaagttatatctttttacaggaacgttttttggaggtttaatctttggtttcgtatacagtaagatattttttctttttatcagaaatctaattgttattggagatgtcagagaacaatatagcttaacggctattagttggctacttattcttactttttttatttattttattatttatctatcagagtaccgattattaaaacgtcaaagtatcacggttatttttaatagcaaagctaagcgtgataatcctagaaaaactagtgtttttgttggactttttggactttttgccctgttaatgggatatcattttgctttaacaagtcccaatgtcacaaccagtttcagccgtttcatttatgctgcctgcttagttactctaggtattttttgcacgttttcgtcaggtgtgattatgttactgactgtcataaagaagagaagagctatctactataatcaacggcgctttgttgtgattgctagtttatttcaccgtatccgcagtaatgctctgtctttggcgactatctgtatttttagcaccgctaccttagttagtttatctgtcttagctagtctctatcttgcaaaggacaatatggttcgtctttcaagtcctagagatgttacggtgctatctacaactgatattgaaccgaatttaatggacatcgctacaaaaaatcatgttactctaactaatcgccagaatttaaaggtttctcaatctgtttatggtaatatcaaaggaagtcatttgtcagttgatcctaatggcggtatggctaatgattatcaaataacagttatttcattggattcttttaatgcttctaataatacccattatcgtttaaaaaatcatgaaattctcacctatgtttcaaatggagcagctgctccctctagctatacaactaatggtgttaaactaaccaatgttaaacaaattaaaaggataaactttattttttctccgctacgctctatgcagcctaatttctttataattactgacaatcgagaaataattcagactattttgaaagaggagctaacatggggaacgatggcaggctaccatgttaaaggaaaaaaaatgaatcagaaagatttttatgatgagcttgagactactaatttcaggcaatttagtgctaatgtagtttcaataagacaggtcaaatcaatgtttaatgctttatttggcggtttactctttgttggtattatttttggaactatttttgcaattttgacagctataactatttattatcaacagctttctgaaggaattcgagaccgagatgattataaggccatgataaaattaggtatgacaaataaaactattcaagacagtattaaggttcaaataaactttgttttcatcttgcccattgcttttgccctattaaatctcatctttgcacttcctattttatataaaataatgacaacttttggatttaatgatgcaggactatttctaagagctgttggaacttgtctgattgtttaccttttcttttattggtttatttgtcattgcacatccaaactatattatcgtttaatatctaaaaaatag","","","73177","MFLPKISFHNLIVNKSLTLPYFAIMTIFSGFNYVLINFLTNPSFYNIPTARILIDILIFGFILISLLMLLYGRYANRFISDERNSNMGIFLMLGMGKKQLLKIIYLEKLYLFTGTFFGGLIFGFVYSKIFFLFIRNLIVIGDVREQYSLTAISWLLILTFFIYFIIYLSEYRLLKRQSITVIFNSKAKRDNPRKTSVFVGLFGLFALLMGYHFALTSPNVTTSFSRFIYAACLVTLGIFCTFSSGVIMLLTVIKKRRAIYYNQRRFVVIASLFHRIRSNALSLATICIFSTATLVSLSVLASLYLAKDNMVRLSSPRDVTVLSTTDIEPNLMDIATKNHVTLTNRQNLKVSQSVYGNIKGSHLSVDPNGGMANDYQITVISLDSFNASNNTHYRLKNHEILTYVSNGAAAPSSYTTNGVKLTNVKQIKRINFIFSPLRSMQPNFFIITDNREIIQTILKEELTWGTMAGYHVKGKKMNQKDFYDELETTNFRQFSANVVSIRQVKSMFNALFGGLLFVGIIFGTIFAILTAITIYYQQLSEGIRDRDDYKAMIKLGMTNKTIQDSIKVQINFVFILPIAFALLNLIFALPILYKIMTTFGFNDAGLFLRAVGTCLIVYLFFYWFICHCTSKLYYRLISKK$","4914 OrfY permease","","OrfY from strain CH43; ABC permease","Membrane, Cytoplasm","This sequence corresponds to gi9802356 in GenBank. Nearest non-mutans neighbor is GI:62514580 from Lactobacillus casei ATCC 334.","

noIPR
unintegrated

unintegrated
tmhmm	$\"[21-41]?$ $\"[51-71]?$ $\"[109-127]?$ $\"[146-166]?$ $\"[196-214]?$ $\"[228-250]?$ $\"[280-300]?$ $\"[516-536]?$ $\"[572-592]?$ $\"[606-626]?$	transmembrane_regions

","","","","","","","","","","","","","","","Thu May 5 17:33:40 2005","Thu May 5 20:47:21 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0917 on the UA159 chromosome.","Thu May 5 20:46:18 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","","Thu May 5 20:46:18 2005","","5","","","","" "MI0014","4928","5284","357","atgcgtattgtaagttcattggtatcgcttttattgactatcttttggatttttgctatagcttttatcccaattggagaccagaatagttttaataaaccagaaatgtggttctttgtttttttcgctattattatttatagtattgttataataagcgattattatctaaagagctttaatcttttgaaagtttatcaaattttagttttgtttattagcatactgtgtgctctttgtggtttatcactaactgctttaggattgaaagtattcactttagctattggaattgttagtcttgttaatacaattatttatttctttttcgctaataaaaaagataatgttgaataa","","","13449","MRIVSSLVSLLLTIFWIFAIAFIPIGDQNSFNKPEMWFFVFFAIIIYSIVIISDYYLKSFNLLKVYQILVLFISILCALCGLSLTALGLKVFTLAIGIVSLVNTIIYFFFANKKDNVE$","5284 OrfZ hypothetical protein","","OrfZ from strain CH43; hypothetical protein","Membrane, Cytoplasm","This sequence corresponds to gi|9802357 in GenBank. There are no near neighbors in the NR database.","

noIPR
unintegrated

unintegrated
signalp	$\"[1-21]?$	signal-peptide
tmhmm	$\"[5-23]?$ $\"[37-57]?$ $\"[67-87]?$ $\"[91-111]?$	transmembrane_regions

","","","","","","","","","","","","","","","Thu May 5 20:54:07 2005","Thu May 5 20:54:07 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","There are no sequences in the UA159 similar to this sequence.","Thu May 5 20:54:07 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","","Thu May 5 20:54:07 2005","","5","","","","" "MI0015","5318","14","96","ATGACCCGTATTTTGGTAATTGATGATGATGCAGATATTTTGGCTCTGATAAAAAATACCTTGCAACTGCAAAACTATCTGGGGAGGATATCATAA","","","3099","MTRILVIDDDADILALIKNTLQLQNYLGRIS*","5399 OrfR response regulator (partial sequence)","","OrfR from strain CH43; predicted response regulator","Extracellular, Cytoplasm","GI:9802351","

InterPro
IPR001789
Domain

Response regulator receiver
PS50110	$\"[3-27]T$	RESPONSE_REGULATORY

InterPro
IPR011006
Domain

CheY-like
SSF52172	$\"[1-26]T$	CheY_like

","","","","","Tue May 10 10:31:33 2005","Tue May 10 10:32:29 2005","Tue May 10 10:32:29 2005","Tue May 10 10:32:29 2005","","","Tue May 10 10:31:33 2005","Tue May 10 10:31:33 2005","","","Thu May 5 20:10:14 2005","Thu May 5 20:11:54 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","","","","","","","","","","","Qi F, Chen P, Caufield PW.Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.Appl Environ Microbiol. 2000 Aug;66(8):3221-9.PMID: 10919773","","Tue May 10 10:31:33 2005","","5","","","","" "MII0001","496","654","159","atgaacaagttaaacagtaacgcagtagtttctttgaatgaagtttcagattctgaattggatactattttgggtggtaatcgttggtggcaaggtgttgtgccaacggtctcatatgagtgtcgcatgaattcatggcaacatgttttcacttgctgt","","","6002","MNKLNSNAVVSLNEVSDSELDTILGGNRWWQGVVPTVSYECRMNSWQHVFTCC","654 gi2853235 mutacin II","","MutII A protein from strain T8","Extracellular, Periplasm","This sequence corresponds to GI:2853235 in GenBank.Nearest neighbor in the NR db is GI:1071699 from Kocuria varians. No similarities to other Smu bacteriocins.","

InterPro
IPR007682
Family

Type-A lantibiotic
PF04604	$\"[5-53]T$	L_biotic_typeA

","","","","","","","","","","","","","Wed May 11 11:29:31 2005","","Thu May 12 14:16:58 2005","Wed May 11 11:29:31 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarity to UA159 chromosomal sequences.","Wed May 11 11:29:31 2005","","","","","","","","","Woodruff WA, Novak J, Caufield PW.Sequence analysis of mutA and mutM genes involved in the biosynthesis of the lantibiotic mutacin II in Streptococcus mutans.Gene. 1998 Jan;206(1):37-43.PMID: 9461412Chikindas ML, Novk J, Driessen AJ, Konings WN, Schilling KM, Caufield PW.Mutacin II, a bactericidal antibiotic from Streptococcus mutans.Antimicrob Agents Chemother. 1995 Dec;39(12):2656-60.PMID: 8592997Li S, Liu T, Xiao X, Yang J, Yang D, Zhuang H, Liu Z.Detection of mutA genes in transmitted strains and nontransmitted strains of mutans streptococci.Caries Res. 39(5):417-21.PMID: 16110215","","Thu Apr 26 09:27:00 2007","","6","","","","" "MII0002","726","3419","2694","atgaacaacccgttattccctgaattcttatcatacatgaaaaaacatgattcgactgtaaaaaagtcgttatccttctacagtgaaaattttattgatataagtatttttaaattgttcgctaaagctcttgtttatttaattaatgaaaagcgagaaaatcaatctttgattggtttaacctcggaagaaaaatatgaatatttcactaagcactatgtacttaccggaataatattagatgaaattcgtactaaatttcctaatatcgttatttcatttcataattactttaactcattaaatatgctaggaaatcaggttacatctaactacttaaatgaccaccaggaccttgttaatcttggtttagtagatcaatctgataagattgtcagccttcaagtagtaggcgatatgcataatgaattagcggtcgttaaagttaatttgacaggtcgttctttattttataaaccgcatttagataattacattgtctataatgagattcttcaattactgaattctaaattaccggctaatcttaaacaaagacaagttaaatcctttgtttcttcagaccattcttggcttgaagaagttaaaagaaatccgttattaaaagaaaacatccataattatttttctcgaatgggagggttaattgcaattgcttattctctcaatatgaccgatttacattttgaaaatatcataagtgacggtgaatatccagttattctggacatggagaccatttgtggtacaactataaataataatgaatttttatttaccatggctcaaaaagaagtaaataataagatatttgattctgtgctaaatacaggcttattacctatgaaaggcttaggaagtatttttggtggtgatgtcagtggtatgatggggggtgagtttaccaagagttttaatcgcatagtagataacaataaagatactattcattttgaaaaaaagattgaacgtttaactaatatgaatcatcttccatattacatcagaaataataaagagatacttatcaaaaattcaccagattatctaacaaatatagtttatggttttaattccacatatgactatattcaagttttaaaaaatgaaataataactatcataaaaaaatatgaatttctaacatgtcgcgtcatttttagacaaactgcccactattcgctaatgctagaagtattaaattctccaatttatcaaaatagcaaagaaaatgttttgagtaaattatcttactcagcttattccaaaggtgttctggaatctgaaaagaaacaatataggtgggaatatccctctcccacaaggttgaattccatcaatatattgatcagcttcaactgttcaattagtagcttaagtccaatagacaatttagaaattaaattatcgagtctttcaagaacagatagacaatttcaagagaagctgattcggttctcgctacaaggaaatatagaattatatttaaatccacaaattaacctaagaagtagtactcagaatcttgagtctaatgagttgataacacgctctatcaatgatattaagcaaaaaattattgataattcattagttgcatctgacgggacgattaattggtttaatgtaagtgtcggagattatgacgaattagaattagagataatggatgatactatatacaagggaatcgcaggaatcaagttagccttccttctaagtagtcgtaattttggtatgagtagtgacaaagtgattcttgacagaattaacaagagtttaagtttcagtgactataccctgaatcgtgaatcattttatgaaggaacttttggaagtcagttgccctcgtataaagagatttctaaggaagatctacaaaatcctaaacagtgggatgctttattaggtgcttctagcactattataggaatttatcaaaactttaaaattaatcctactttcaaagaaattattgaacaatatgctgattatttagttatatctttacaaaagaacagtattaacggatattcttggtttgacgaagaacatcaagatttggtaaatgttagttttgcacatggtaattcaggatgtatgactgccttgttaatttcttatgctctattaggtaaatcagaatatttagatacgtttcaaaagcttgggaaagtgaacaaaaaattcatgatagattgtggatgggaggatacacgtaatactgatagattgtcttcagctaattggtgtcatggaagtacgggcgctttaacctctagacttttatggtttaaactaaataagaaatttaatattcttaatgaacatgatatccaacgggtttatcttgaaattgaccactctgtcaatgatataattgataaagggttatcaattaataatttttcactttgtcacggtattatgggtaacttgattgctctaaacgaatacagcctcgctttctccaatcagaagatccaacaattagttcagagtactttgatttcattatgctcagtagggatgaaaaaagattggctctgtggtgtcaatgacctgttttacaataatggtttaatgacaggcctagctggcattttatatggaatcataaaaatatattatgatgataattacgaccagcatgtcttaaatctttcattttac","","","103147","MNNPLFPEFLSYMKKHDSTVKKSLSFYSENFIDISIFKLFAKALVYLINEKRENQSLIGLTSEEKYEYFTKHYVLTGIILDEIRTKFPNIVISFHNYFNSLNMLGNQVTSNYLNDHQDLVNLGLVDQSDKIVSLQVVGDMHNELAVVKVNLTGRSLFYKPHLDNYIVYNEILQLLNSKLPANLKQRQVKSFVSSDHSWLEEVKRNPLLKENIHNYFSRMGGLIAIAYSLNMTDLHFENIISDGEYPVILDMETICGTTINNNEFLFTMAQKEVNNKIFDSVLNTGLLPMKGLGSIFGGDVSGMMGGEFTKSFNRIVDNNKDTIHFEKKIERLTNMNHLPYYIRNNKEILIKNSPDYLTNIVYGFNSTYDYIQVLKNEIITIIKKYEFLTCRVIFRQTAHYSLMLEVLNSPIYQNSKENVLSKLSYSAYSKGVLESEKKQYRWEYPSPTRLNSINILISFNCSISSLSPIDNLEIKLSSLSRTDRQFQEKLIRFSLQGNIELYLNPQINLRSSTQNLESNELITRSINDIKQKIIDNSLVASDGTINWFNVSVGDYDELELEIMDDTIYKGIAGIKLAFLLSSRNFGMSSDKVILDRINKSLSFSDYTLNRESFYEGTFGSQLPSYKEISKEDLQNPKQWDALLGASSTIIGIYQNFKINPTFKEIIEQYADYLVISLQKNSINGYSWFDEEHQDLVNVSFAHGNSGCMTALLISYALLGKSEYLDTFQKLGKVNKKFMIDCGWEDTRNTDRLSSANWCHGSTGALTSRLLWFKLNKKFNILNEHDIQRVYLEIDHSVNDIIDKGLSINNFSLCHGIMGNLIALNEYSLAFSNQKIQQLVQSTLISLCSVGMKKDWLCGVNDLFYNNGLMTGLAGILYGIIKIYYDDNYDQHVLNLSFY","3419 gi2853236 orf1","","orf1/MutM protein from strain T8","Cytoplasm","This sequence corresponds to gi2853236 in GenBank. It is similar to the other MutM sequence from T8 as well as to the modifying enzyme for proSmb from the Smb strain. It is weakly similar to MutC proteins from Mut I sequences.Nearest neighbor from the NR db is GI:2581778 from Lactococcus lactis subsp. lactis.","

InterPro
IPR007822
Family

Lanthionine synthetase C-like
PF05147	$\"[561-893]T$	LANC_like

noIPR
unintegrated

unintegrated
SSF55229	$\"[363-385]T$	SSF55229

","","","","","","","","","","","","","Wed May 11 11:43:34 2005","","Wed May 11 13:34:46 2005","Wed May 11 13:34:46 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","There are no similarities between this sequence and the chromosomal UA159 sequence.","Wed May 11 11:43:34 2005","","","","","","","","","Novk J, Caufield PW, Miller EJ.Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans.J Bacteriol. 1994 Jul;176(14):4316-20.PMID: 8021218Qi F, Chen P, Caufield PW.Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in Streptococcus mutans.Appl Environ Microbiol. 1999 Feb;65(2):652-8.PMID: 9925596Woodruff WA, Novak J, Caufield PW.Sequence analysis of mutA and mutM genes involved in the biosynthesis of the lantibiotic mutacin II in Streptococcus mutans.Gene. 1998 Jan;206(1):37-43.PMID: 9461412Chikindas ML, Novk J, Driessen AJ, Konings WN, Schilling KM, Caufield PW.Mutacin II, a bactericidal antibiotic from Streptococcus mutans.Antimicrob Agents Chemother. 1995 Dec;39(12):2656-60.PMID: 8592997","","Wed May 11 13:34:46 2005","","6","","","","" "MII0003","2970","3419","450","actgatagattgtcttcagctaattggtgtcatggaagtacgggcgctttaacctctagacttttatggtttaaactaaataagaaatttaatattcttaatgaacatgatatccaacgggtttatcttgaaattgaccactctgtcaatgatataattgataaagggttatcaattaataatttttcactttgtcacggtattatgggtaacttgattgctctaaacgaatacagcctcgctttctccaatcagaagatccaacaattagttcagagtactttgatttcattatgctcagtagggatgaaaaaagattggctctgtggtgtcaatgacctgttttacaataatggtttaatgacaggcctagctggcattttatatggaatcataaaaatatattatgatgataattacgaccagcatgtcttaaatctttcattttac","","","17042","TDRLSSANWCHGSTGALTSRLLWFKLNKKFNILNEHDIQRVYLEIDHSVNDIIDKGLSINNFSLCHGIMGNLIALNEYSLAFSNQKIQQLVQSTLISLCSVGMKKDWLCGVNDLFYNNGLMTGLAGILYGIIKIYYDDNYDQHVLNLSFY","3419 gi4103629 MutM","From GenBank, t\"his protein is the modification enzyme catalyzing dehydration and the formation of thioether bridges.\"","MutM modifying enzyme from strain T8","Cytoplasm, Extracellular","his seqquence corresponds to both gi|2853236 and gi|4103629 in GenBank. It is weakly similar to gi|55847607 from Smb and to MutC sequences from MutI.Nearest neighbor in the NR db is GI:52005623 from Bacillus licheniformis ATCC 14580.","

InterPro
IPR007822
Family

Lanthionine synthetase C-like
PF05147	$\"[4-145]T$	LANC_like

","","","","","","","","","","","","","Wed May 11 11:53:57 2005","Wed May 11 11:53:57 2005","Wed May 11 11:53:57 2005","Wed May 11 11:53:57 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence shows no similarity to the UA159 chromosomal sequence.","Wed May 11 11:53:57 2005","","","","","","","","","","","","","6","","","","" "MII0004","3477","5591","2115","ttgaaattagtattacaaaataatgagcaagattgtttaattgcctgttatgcaatgattctttcctcttttggctgtaatgttagtctagaagatctataccttgatgaatatattccgccagacggcctatccgtttcatatttacatagtttaaatactaaattccgtcttaagatgcaagtattaaaaggcgatgggcaacaagttcttgaatatatctatcaacataaatgtaaggcaatcgcctactggaaaaatagccatttcgttgttgttgataaatgtactaagaagtcggtcaatataatggatcctagtttaggcacaataactattcctataagcagtttccttgataacttcagtagctatattttaatcttttctaagcagtctaactataggccagtaaaaataaattctcctctaactggtttaataaaaataacctatacaggacttaacttagtcgaatatattggagcactttttttaattgagttagtatcaattattttatgccgtttacctacgagtatactaaatcaaaatattaagtggttaagcagccttttgattggtactacgctccttatatttcgttttataggatacttattagagacaaaaggtcagattaaatcaaatataaaatatgaaaaaaatgttaccaagtcattatttcaaggaactttaagccactccttgcttttttttagaaataatactcccggaagtattctggaaaaagtaaatttaaaatctcgaattagagatagtattcaaactcaactgattccttcaattattaatattttttctttattggtgctctcaatatatctattcatagtttctcgattgcttgctttcttgtcaatattactgctaattatttatgctatcattaattatttaatctacagaaaaattcttaatgccaatttaaaatatgttcaacaaacaattactgtttcagacaaaattcaagaaggtttatcccaaattgatcaaattaaaacccaaggaactgaagatacgtgggaaaaagaatgggtggactctagtatgaatagtcaaattttatataatgatatattatcacttcagagtctttctaatttggttaatcaattatttactatttccagcacggtaatattaatgtattcagggattttcttaatatccttgaataaaattaatatggcagacttagtattgttccagacactctttgtctctctgttagcttcagtagtccaatttcaagctaggcgcttagaaatttctaatttaagtgtttattcaaagaaaatccaaagtttattcacgagattcaaaagaaagccagatcagataattccaaatgatcattacgttcttaaagcgaaggatgtttcattcagctattatggaaataagcaagtaattaaagattttaatttaaccattcgacaaggtgaaaaaattgtaatattgggtgagtcaggctcaggtaagacaacgttactcaatgttctattaggattgtataattatcaaggggatatttcttatggaatcgaagatttcagaaaaaaactaggtgtcgttacccaaaatgtgaatttaaccagcggtccacttataaaaaatttaattggcaactcaattattacttctaaaattctaaatgaggtaaattttgctataaatgctgttaacatgatggaagctattaatcaaatgcccaaaaagattttttcaaacctttttcagcagggtaaaaatctctctgggggacaagttcaaagattattggtagctaggtcacttttgaataatagtcaattgctaatttgggatgaaccattcagtaatttagataatctcaatcgagagttaatttacagtaacatcctgaattcagagcaatataataataaaactattattttatctagtcatcatactgactgtattaaatatatggatcggattatcttcattaattcaaacggtcaaatagatattgggagcgatgctgaattaagaattagaaatctcgaatacaaacaatttattggcatgaataaaggagaaaaatatgacgaaaccattgttatcaat","","","80259","LKLVLQNNEQDCLIACYAMILSSFGCNVSLEDLYLDEYIPPDGLSVSYLHSLNTKFRLKMQVLKGDGQQVLEYIYQHKCKAIAYWKNSHFVVVDKCTKKSVNIMDPSLGTITIPISSFLDNFSSYILIFSKQSNYRPVKINSPLTGLIKITYTGLNLVEYIGALFLIELVSIILCRLPTSILNQNIKWLSSLLIGTTLLIFRFIGYLLETKGQIKSNIKYEKNVTKSLFQGTLSHSLLFFRNNTPGSILEKVNLKSRIRDSIQTQLIPSIINIFSLLVLSIYLFIVSRLLAFLSILLLIIYAIINYLIYRKILNANLKYVQQTITVSDKIQEGLSQIDQIKTQGTEDTWEKEWVDSSMNSQILYNDILSLQSLSNLVNQLFTISSTVILMYSGIFLISLNKINMADLVLFQTLFVSLLASVVQFQARRLEISNLSVYSKKIQSLFTRFKRKPDQIIPNDHYVLKAKDVSFSYYGNKQVIKDFNLTIRQGEKIVILGESGSGKTTLLNVLLGLYNYQGDISYGIEDFRKKLGVVTQNVNLTSGPLIKNLIGNSIITSKILNEVNFAINAVNMMEAINQMPKKIFSNLFQQGKNLSGGQVQRLLVARSLLNNSQLLIWDEPFSNLDNLNRELIYSNILNSEQYNNKTIILSSHHTDCIKYMDRIIFINSNGQIDIGSDAELRIRNLEYKQFIGMNKGEKYDETIVIN"," ABC transporter MutT","","MutT ABC tansporter protease (leader proteolysis) from strain T8","Membrane, Cytoplasm, Extracellular","This sequence corresponds to gi4103630 in GenBank. Nearest neighbor in the NR db is GI:2581779 from Lactococcus lactis subsp. lactis.Other similarities are to SmbG (gi55847611), mutT (gi5918764 and gi9802002), orfX (gi9802355).","

InterPro
IPR001140
Domain

ABC transporter, transmembrane region
PF00664	$\"[188-421]T$	ABC_membrane

InterPro
IPR002078
Domain

RNA polymerase sigma factor 54, interaction
PS00675	$\"[492-505]T$	SIGMA54_INTERACT_1

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[592-635]T$	Q9ZAB2_STRMU_Q9ZAB2;
PF00005	$\"[489-669]T$	ABC_tran
PS50893	$\"[463-692]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[488-678]T$	AAA

InterPro
IPR005074
Domain

Peptidase C39, bacteriocin processing
PF03412	$\"[4-134]T$	Peptidase_C39
PS50990	$\"[6-129]T$	PEPTIDASE_C39

InterPro
IPR011527
Domain

ABC transporter, transmembrane region, type 1
PS50929	$\"[156-424]T$	ABC_TM1F

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[426-690]T$	no description
PTHR19242	$\"[86-125]T$ $\"[158-700]T$	ATP-BINDING CASSETTE TRANSPORTER
tmhmm	$\"[160-178]?$ $\"[188-208]?$ $\"[264-284]?$ $\"[289-309]?$ $\"[377-397]?$ $\"[407-427]?$	transmembrane_regions

","","","","","","","","","","","","","Wed May 11 12:11:01 2005","","Wed May 11 13:35:35 2005","Wed May 11 13:35:35 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","","","","","","","","","","","Qi F, Chen P, Caufield PW.Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in Streptococcus mutans.Appl Environ Microbiol. 1999 Feb;65(2):652-8.PMID: 9925596Novk J, Caufield PW, Miller EJ.Isolation and biochemical characterization of a novel lantibiotic mutacin from Streptococcus mutans.J Bacteriol. 1994 Jul;176(14):4316-20.PMID: 8021218","","Wed May 11 13:35:35 2005","","6","","","","" "MII0005","5569","6474","906","atgacgaaaccattgttatcaattaataatttatccaaatcatttggtaaccaaaaagttttggaccatcttaatatgactattagtcctggtgaaatttatggcttcctgggagtgaatggagcaggtaaatcaactgctatgaaaattattttagggctactccctaaagatagtggcgaaattgttgccctaggccgccctttgcctgaaaaccgtagtcagatcttaccagaaattggggctttaattgaagaacccgctttttacccaaatttaactggttttgaaaacttacaactcattcaagaattagctaacttaccaaaagataatattaaagttgttatggaagccactggtatttactatgctaaagataaattagtacgtaattattctttagggatgaaacaacggcttggcatttccatggctttgatcaaatttcctaaatttcttattttagatgagccaacaaacgggctagaccccgatgggattcatcaaatgcgacaattaattcgctcattaccacaaaagtttaatatgacgatcctaatttcaagtcatattctttcagaaatcgaaaatctagctgatactgttgggattattaaagatgggcaccttatttatgaaggtggaattaatcaattacttaaccaagagcagaagtaccagttaaaagttaataatctagaaaaggccgctcagatcattcagcattacgataacaagattggcattgttaaaaatgatgatgacattcttttaatatcattacctgactgtacgttggttccagacttaatcgcccaattagtttataacgaacttcaaatatacgaaatttatggagtaaagaagactttagaatcagtctttctagatctaactaaggag","","","33724","MTKPLLSINNLSKSFGNQKVLDHLNMTISPGEIYGFLGVNGAGKSTAMKIILGLLPKDSGEIVALGRPLPENRSQILPEIGALIEEPAFYPNLTGFENLQLIQELANLPKDNIKVVMEATGIYYAKDKLVRNYSLGMKQRLGISMALIKFPKFLILDEPTNGLDPDGIHQMRQLIRSLPQKFNMTILISSHILSEIENLADTVGIIKDGHLIYEGGINQLLNQEQKYQLKVNNLEKAAQIIQHYDNKIGIVKNDDDILLISLPDCTLVPDLIAQLVYNELQIYEIYGVKKTLESVFLDLTKE","6474 gi4322367 ABC transporter MutF","","MutF ABC transporter from strain T8 ATP-binding/immunity","Cytoplasm, Membrane","This sequence corresponds to gi4322367 from GenBank. Nearest neighbor from the NR db is GI:2581773 from Lactococcus lactis subsp. lactis.Other similarities are to gi9802352, gi4103631, gi55847608, gi9802003 among others.","

InterPro
IPR003439
Domain

ABC transporter related
PD000006	$\"[132-175]T$	ABC_transporter
PF00005	$\"[31-209]T$	ABC_tran
PS00211	$\"[133-147]?$	ABC_TRANSPORTER_1
PS50893	$\"[6-233]T$	ABC_TRANSPORTER_2

InterPro
IPR003593
Domain

AAA+ ATPase, core
SM00382	$\"[30-210]T$	AAA

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[3-237]T$	G3DSA:3.40.50.300
PTHR19222	$\"[6-236]T$	PTHR19222
PTHR19222:SF16	$\"[6-236]T$	PTHR19222:SF16
SSF52540	$\"[4-227]T$	SSF52540

","","","","","","","","","","","","","Wed May 11 12:27:34 2005","","Wed May 11 12:27:34 2005","Wed Sep 27 14:24:29 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu1050, Smu1649, Smu0944 and other ABC transporter genes on the chromosomal UA159.","Wed May 11 12:27:34 2005","","","","","","","","","","","","","6","","","","" "MII0006","6484","7221","738","atgagacaactacgtagtgaaatccaaaagtatcgtcggaatcgcctttggttgccgattttaggtctatttttattttcaatctattggtgttctgttagcaataatcttcagattaataaaaattcatccgatattttccagatcttaatttttaatctctacactatcaacaatctaattattcccttcagtgcagccctacttgcttcccgtatggtgatgattgataaaaaaaatcgtatgtatagcgttttatttaccaatggtgaaaacgggattggtttatttctaagtaaatatgtcttaggacttctaatcctcttcattggatttgtatgccaacttatcttcacatttatctctagttatcaatatcatgcgattattaataaaaatgaattcattttattcattattaccatgctattaggaagtgggacaattttgcttattcaattgctgctttcttttgtaattcagtcatcaattataccaatagttatcgggcttgctggtagctttctgagtatgctgacttcaggagtattggcaaagcagattactatttttattccttgggaatatctttcaactttgaacccttatactattaatgatagtgggattcacctatcagccaattatccactctactttagtttagttatacttattcatctatttctattagttacctcaatttggttagtatttaaagaaagggttattcatgaa","","","28250","MRQLRSEIQKYRRNRLWLPILGLFLFSIYWCSVSNNLQINKNSSDIFQILIFNLYTINNLIIPFSAALLASRMVMIDKKNRMYSVLFTNGENGIGLFLSKYVLGLLILFIGFVCQLIFTFISSYQYHAIINKNEFILFIITMLLGSGTILLIQLLLSFVIQSSIIPIVIGLAGSFLSMLTSGVLAKQITIFIPWEYLSTLNPYTINDSGIHLSANYPLYFSLVILIHLFLLVTSIWLVFKERVIHE","7221 gi4322368 membrane spanning protein MutE","","membrane spanning ABC element from strain T8","Membrane, Cytoplasm","This sequence corresponds to gi|4322368 in GenBank. Nearest neighbor in the NR db is gi|38142407 from Staphylococcus warneri.","

noIPR
unintegrated

unintegrated
signalp	$\"[1-34]?$	signal-peptide
tmhmm	$\"[15-33]?$ $\"[49-71]?$ $\"[101-121]?$ $\"[135-155]?$ $\"[165-185]?$ $\"[219-239]?$	transmembrane_regions

","","","","","","","","","","","","","Wed May 11 13:20:53 2005","","Wed May 11 13:20:53 2005","Wed May 11 13:20:53 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu1051 and, less so, to Smu1648 in the UA159 genome.","Wed May 11 13:20:53 2005","","","","","","","","","Qi F, Chen P, Caufield PW.Functional analyses of the promoters in the lantibiotic mutacin II biosynthetic locus in Streptococcus mutans.Appl Environ Microbiol. 1999 Feb;65(2):652-8.PMID: 9925596","","Wed May 11 13:20:53 2005","","6","","","","" "MII0007","7217","7960","744","atgaatagtcggttaatcaaatgggagttaaaaaaacaacagcacacctatctcccaattattttattttgctttattattgttgctgtttttcttgggtcttttctatatttcatgaatcagaaagtatttagtagagaccaaacgcaatggctcgctttatggggcgaaattggcttattttatgcccagttatttttcccgctgttaattgccgttattgtcaatactatctggtcccaagagctggatcggcatagctggtatctaccatccttgcttccaattaggggaggctacctcctaattgctaaggttattattgcttctttttatgtattactgagccaaactttactgctcgttttatattatctcatcgcaagtctagctcgttttccgctaactcataccaatccatctacgtttatttggtggggcctgatgggttggcttggtagcttttctattattgccatccaattcttctttgctatcaagtttaatcgatttacttcactaattttagcattaatcctaggattggggaattttgtaacactattgatgggacaggcagcttttatggtatacccctactcgcagattgccgttggcatgcgagttaggtcctatgagacaatgtcactttctgaattcacttatttcctcattattaacctagtttggattattattgggctttccttttctaagattacaatgctaagaaaatatcatttc","","","28930","MNSRLIKWELKKQQHTYLPIILFCFIIVAVFLGSFLYFMNQKVFSRDQTQWLALWGEIGLFYAQLFFPLLIAVIVNTIWSQELDRHSWYLPSLLPIRGGYLLIAKVIIASFYVLLSQTLLLVLYYLIASLARFPLTHTNPSTFIWWGLMGWLGSFSIIAIQFFFAIKFNRFTSLILALILGLGNFVTLLMGQAAFMVYPYSQIAVGMRVRSYETMSLSEFTYFLIINLVWIIIGLSFSKITMLRKYHF","7960 gi4322369 membrane protein MutG","","MutG ABC element in strain T8; membrane spanning protease","Membrane, Cytoplasm","This sequence corresponds to gi|4322369 in GenBank. The nearest neighbor in the NR db is gi|38142408 from Staph warneri.","

noIPR
unintegrated

unintegrated
SSF103473	$\"[1-115]T$	SSF103473

","","","","","","","","","","","","","Wed May 11 13:26:10 2005","","Wed May 11 13:26:10 2005","Wed May 11 13:26:10 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu1052 and Smu1647 in the UA159 chromosome.","Wed May 11 13:26:10 2005","","","","","","","","","","","","","6","","","","" "MII0008","8759","8965","207","atggcaatcgtttcagcagaaaaatttgtccaagcagctcgtgataatggttatgctgttggtggatttaacacaaataacttggagtggtcccaagttatcttgcgtgcggcagaagctaaaaaagctccagttcttatccaaacttcaatgggtgctgccaaatatatgggtggatacaaactttgtaaagtccttattgaagat","","","7434","MAIVSAEKFVQAARDNGYAVGGFNTNNLEWSQVILRAAEAKKAPVLIQTSMGAAKYMGGYKLCKVLIED","8965 gi4322370 fructose bi-phosphate aldolase","","fructose bi-phosphate aldolase","Cytoplasm","This sequence corresponds to gi62527282 in GenBank. Nearest neighbor in the NR db is GI:55823786 from S.thermophilus.See GI:24376476 from UA159 S.mutans.","

InterPro
IPR000771
Family

Ketose-bisphosphate aldolase, class-II
PD002376	$\"[1-68]T$	K_bP_aldolase
PF01116	$\"[2-69]T$	F_bP_aldolase

InterPro
IPR013785
Domain

Aldolase-type TIM barrel
G3DSA:3.20.20.70	$\"[1-68]T$	Aldolase_TIM

noIPR
unintegrated

unintegrated
SSF51569	$\"[2-62]T$	SSF51569

","","","","","","","","","","","","","Wed May 11 13:29:20 2005","","Wed May 11 13:29:20 2005","Wed May 11 13:32:37 2005","","","","yes","Fri Feb 20 15:41:32 MST 1998","This sequence is similar to Smu0088 from the UA159 chromosome.","Wed May 11 13:32:37 2005","","","","","","","","","","","","","6","","","","" "SMUpUA140_1","398","1171","774","ATGGTCAGAGGTTTAAAAGAAATTGAATTGAATGATAGAGATCGATTTGTGTTATATCTCTTGGATAAATTTAGGGTATTAGATGCTAAGAGTGTAGCTGTTATGGCTAGTTTTTCAAGTGAGTCTTATGCTGCTATTCGTTTGCAGAAATTAGCTCGTTATGGCTATATTAAGCGTGAAAGAATAGTTACCTCTCTTCCATTGGTTCATTATTTAACGTCAAAAGGTAATGATGAAATCAATGATATTAGGAGAAGACAAATTAAGCCAAGAATTGGAACACTAGAACACGAGCTAGCAGTAGGCAGAGTAGCCTCTTATTTAACTTTAAATAAAGGGATAGAGCCTATTTCTATGATAACAGACCGTGATATGCGAGCTTATGAAAGCCAGATAAATGACAATAGAGTCATGTCACGAAAAGGGGATATTGTCTTTTTATGTCCTAAAACTAATAAAAAAGTATTAGTAGAAGTTGAATTGACATTTAAGGGGGTCTCCAGAACCAAGGAAAATATTCGAAAGAATAAAAGAATATCAGATGAACAGCTCTGGTTTTATCCAAAACATAAAAAGGTTCTTGAAAAGGTTTTGAAGGAACAAAATATTGATAATAGATTTTATCTTGAAGATTTGTCTATTATTCCAGCTAATCAAATGATAGACTACCTCTTTCAAGATATAGATCGTTTTGAGAATATAGAATCATATTTCATAAATAACTTTATTGAACAACAAGGAGAAGGAGGTGTTTTAGATAAATGGACAACAATT","","","30319","MVRGLKEIELNDRDRFVLYLLDKFRVLDAKSVAVMASFSSESYAAIRLQKLARYGYIKRERIVTSLPLVHYLTSKGNDEINDIRRRQIKPRIGTLEHELAVGRVASYLTLNKGIEPISMITDRDMRAYESQINDNRVMSRKGDIVFLCPKTNKKVLVEVELTFKGVSRTKENIRKNKRISDEQLWFYPKHKKVLEKVLKEQNIDNRFYLEDLSIIPANQMIDYLFQDIDRFENIESYFINNFIEQQGEGGVLDKWTTI","1171","","rep protein","Cytoplasm","This sequence corresponds to gi13937268 in GenBank. It is similar to a predicted rep protein in the S.mutans plasmid pLM7p04 (GI:14602224); otherwise no similarity is found to the NR database at this time.","

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-76]T$	SSF46785

","","","","","","","","","","","","","","","Sat Jun 3 15:56:46 2006","Tue Jun 6 09:38:36 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities to the chromosomal genes are found.","Sat Jun 3 16:05:51 2006","","","","","","","13897500","Thu Jun 1 17:33:51 2006","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID:11591133","","Tue Jun 6 09:38:36 2006","","7","","","","" "SMUpUA140_2","1159","2823","1665","ATGGACAACAATTTAGAAGAGACAATAGGTGCTAAAGAAGCGGAGATTACAGGTGAAATCTTTTTACTAATCAGTTTTCTTTTAGCACCGTTTGCAGGTTTCATTTCCATACTTTGTTATGGTCTTTCTCGCCTTTTATTGGATCAGCTAAAGGCAACCTTGTTGCTATTTTTTACTGGGGTAATCATGATTATTAGTTTAACCTTTTCAATAAGATTTCCTAATTTCAAGGATTTTCCTATTTTAAAAGCAATTCAAGATTATTTATTGTTTTTATTGGGAAAATCTCAAATAGAACCATCTTCTATCTTATCTCTTTGGTTTAAGAGCTTTAATTGGTATATATTAAGCATGACTATGATAACGCAAGGTTTTGGTCTTATACTGTTACCAAAAAGTCAAAAAGAAAAGCTAAAAGATGTTAGGAAAAAAGAAGAAAGGAAGCACTTATCTAGTCGAAAGAGCAGTAAAGTGCTTGATATGAGCAGTAAAAAACATCTTTTTACTGCAGGGACAACAGGTTCAGGGAAATCAGCAAATATTTTGCGTTATATTGATGATACACTAAAAAATGATGGTTTTTCAGTCATCATTGATGGTAAAGGTGGACTTGGAGACTATGATTTAGCAACTGTTACACTAAAATTAGCTAAAAAATATAATAGGAAAGTCTATATTATCAATCAAACGGATGTAGAACAAACGAATGCTTACAATCCTTTCATGGGCTTATCTGCGACGCAAGTTAAAGATATGCTCATTAATATGAGTGACTGGGAAAGTGACCACTATAAGACATTATCAGCTCGATACTGGCAGGTTATGGTCGATGTGATGCTTAAATGTCATATCCCAATTAGTTTTGAAAGTCTCATTTATTTTTCGTTTAAAAAACATTTGTTAAGTTTGCTAGATGAAGCTATAAAGAAAGACCTAATTGAATCAGAACTATATCAGTTAGCAGAAAGTCTTGCTAATGGTGAAAGTGGCACACAAGCAGAAATATCTATTGCTAGAAGCGCTATTGTTTATGAAGGTGATGGACAAAAATTATTTAGTAGCCAAAATGCTTTCAATATCAGCAAGGCATATGAGGAAAATGCCATTGTTTTAGTTTTATTAAACGAGTTTAATTATAGTGATTTTGCTCGTTCAACAGGGAAAATAGTTATTGATGATATTAAGAATCTTGTCGGACAGCTACAAAAAAAGCAACAGAATCATCAGTTAGACGGAAGAAAAATCCTATTTATTTTTGAAGAATTAGGAGTGTATGTCGATATAGGTATAGAGGGGTTATTGAATAGAACAAGGTCGATTGGTGCTAAAGTCATCTGTTCAGTGCAAACAACGGCTGATATAGACCAAATTAGCCCAGAACTGACGCGTCAGATAATGGGGAATTGTAATGAATATATGATTATGCGAGTATCAGACCCAGACAGTGCAGAATTAATATCAAAAATGATCGGGACCAACAAAACAATCAAAAAAACATTTAGAACGAATGATAAAATTGAAACAGGTGACTCTAGTAATGTATTGACTGATAGTTTTAAAATTAGTCCAAATGAAATAAAGAACTTACCAGACCTCTTTGGGTTCTACTATTCAAAAAGTACCCCAAATAGCATTAAACGTTTTAAAACAGCATTTATTAAAATT","","","62702","MDNNLEETIGAKEAEITGEIFLLISFLLAPFAGFISILCYGLSRLLLDQLKATLLLFFTGVIMIISLTFSIRFPNFKDFPILKAIQDYLLFLLGKSQIEPSSILSLWFKSFNWYILSMTMITQGFGLILLPKSQKEKLKDVRKKEERKHLSSRKSSKVLDMSSKKHLFTAGTTGSGKSANILRYIDDTLKNDGFSVIIDGKGGLGDYDLATVTLKLAKKYNRKVYIINQTDVEQTNAYNPFMGLSATQVKDMLINMSDWESDHYKTLSARYWQVMVDVMLKCHIPISFESLIYFSFKKHLLSLLDEAIKKDLIESELYQLAESLANGESGTQAEISIARSAIVYEGDGQKLFSSQNAFNISKAYEENAIVLVLLNEFNYSDFARSTGKIVIDDIKNLVGQLQKKQQNHQLDGRKILFIFEELGVYVDIGIEGLLNRTRSIGAKVICSVQTTADIDQISPELTRQIMGNCNEYMIMRVSDPDSAELISKMIGTNKTIKKTFRTNDKIETGDSSNVLTDSFKISPNEIKNLPDLFGFYYSKSTPNSIKRFKTAFIKI","2823","","mob protein; type IV secretion protein","Membrane, Cytoplasm","This sequence corresponds to GI:13937267 in GenBank. It is similar to gi5420109 from S. thermophilus and to gi76797322 from Thermoanaerobacter ethanolicus ATCC 33223. It is similar to orf3from the S. mtans plasmid pLM7p03 (GI:14602223).","

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[134-537]T$	G3DSA:3.40.50.300
SSF52540	$\"[165-554]T$	SSF52540

","","","","","","","","","","","","","","","Sun Jun 4 14:33:17 2006","Tue Jun 6 09:27:44 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","","","","","","","","","13897499","Thu Jun 1 17:34:50 2006","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Sun Jun 4 14:33:45 2006","","7","","","","" "SMUpUA140_3","2839","3402","564","ATGGCTAAAGTAATATTACTAACTTCAGATTATCAAAGAGACTACTCAGGAATTTTTCTAAATCCTTATGTTTATGGGGGTTCAGTTGAAACTTGTGCAATTGATAAAAACAATACTGTAAAATGCATTAATCTCAAATTTGGGAATAATTATGATATCAAATACTGTGTTATCGAGTTAAAAGATGGTAATTATGTCTATGGGAGTTATCATGATTTACTACCTAAAATTCAAAGTGGAGAGCTTAAGATTATATTTTCTGACCGTCCCCTTGGAGATGATGAAGAAGAATTTTGGAATTATGAAGAACTCCCATTAACAAGAATTTTCAATATGCGAGAAAGTTGGCTAGAAAATGAATCCTTATATAGAATTGTACAAATCATACAAGATATTGCTCGTCTAAAGATAGCCTCACAAAATGAGTTAACAGATAGTGAAGTCTTACTTATCAGAGATGAAGCTATAAAAGAGTTTTTGGATAAGAAGAAAGTAGAAGAAGCTAAGGAAGAGAATATAAGTAACAAAGAAAAACAAAAAAGATGGTGGGAAATATGGAAATTC","","","22298","MAKVILLTSDYQRDYSGIFLNPYVYGGSVETCAIDKNNTVKCINLKFGNNYDIKYCVIELKDGNYVYGSYHDLLPKIQSGELKIIFSDRPLGDDEEEFWNYEELPLTRIFNMRESWLENESLYRIVQIIQDIARLKIASQNELTDSEVLLIRDEAIKEFLDKKKVEEAKEENISNKEKQKRWWEIWKF","3402","","hypothetical protein","Cytoplasm","This sequence corresponds to GI:13937266 in GenBank. It is similar to orf2 of the S.mutans plasmid pLM7p02 (GI:14602222) otherwise there are no similarities to the NR database found at this time.","No hits reported.","","","","","","","","","","","","","","","Sun Jun 4 14:38:09 2006","Tue Jun 6 09:20:38 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities seen to the chromosomal genes.","Sun Jun 4 14:38:09 2006","","","","","","","13897498","Thu Jun 1 17:35:28 2006","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Tue Jun 6 09:12:13 2006","","7","","","","" "SMUpUA140_4","3466","3780","315","ATGACTGATAGCAAGCAAGTCCAAATTATTATCAGGACTACAAAAGAAGAAAAAAATGAAATCATGGAAGAATCAAAGGAAAAAGGTGTTTCCATGAATGAATTCATTAAGGAAAAACTATTTGGAAGTTCAAAAAAAGATATCAATAGTGATATCAATGATAGCGATAATGATATCACTATTGATATCATTGATATTCTTCGAGAACAAGTATCAATCAAAGATGAACAAATTAAAGAATTACATCATCTCTTGTACAATCGAGATACAAAATTGTTAGAGTCCCCAAAACATTGGTGGCAATTTTGGAAATCC","","","12519","MTDSKQVQIIIRTTKEEKNEIMEESKEKGVSMNEFIKEKLFGSSKKDINSDINDSDNDITIDIIDILREQVSIKDEQIKELHHLLYNRDTKLLESPKHWWQFWKS","3780","","hypothetical protein","Cytoplasm","This sequence corresponds to gi13937265 in GenBank. No similarities are found to the NR database at this time.","No hits reported.","","","","","","","","","","","","","","","Tue Jun 6 08:51:39 2006","Tue Jun 6 08:52:06 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities are found to the S. mutans chromosomal genes.","Tue Jun 6 08:51:39 2006","","","","","","","13897497","Thu Jun 1 17:36:12 2006","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Tue Jun 6 09:11:56 2006","","7","","","","" "SMUpUA140_5","4233","4592","360","ATGCCGATGAGGTTTTTGCAAAGTATGAATTATAAAGTGAAATTTACCCAGCCAGCTATTGATGATTTAGATGATATTTATAGTTATTATGAGACTGAACTTTCAAAAACGTCTGCCGATAAAGTGATGAAAAGTCTAAGAGAAGCAACTAATTTATTAACTTTTTCACCAGAAGGCGGGATAGATTTCAATAAGAGAATTGGTCAAGAAGTTATTCAAGGACAGTCTCTTAGAATGTTTGTAGCTCAGCAATATCTCATATTCTATATTGTAGTTCATTCAGAAGTCCGTATTATGCGAATTATCAGCACTAAAACAAACTATATGAACGAATTGGAAAATTTATTTAAGAATTTTAAA","","","14139","MPMRFLQSMNYKVKFTQPAIDDLDDIYSYYETELSKTSADKVMKSLREATNLLTFSPEGGIDFNKRIGQEVIQGQSLRMFVAQQYLIFYIVVHSEVRIMRIISTKTNYMNELENLFKNFK","4592","","hypothetical protein possible stabilization element","Cytoplasm","This sequence corresponds to GI:13937264 in GenBank. It is similar to orf1 from the S. mutans plasmid pLM7p01 (GI:14602221) A weak similarity is suggested for GI:14972110 from S.pneumoniae and weaker still similarities to various plasmid stabilization elements.","

InterPro
IPR007712
Family

Plasmid stabilization system
PF05016	$\"[13-108]T$	Plasmid_stabil

InterPro
IPR012753
Family

Addiction module toxin, RelE/StbE
TIGR02385	$\"[12-112]T$	RelE_StbE

","","","","","","","","","","","","","","","Tue Jun 6 09:11:39 2006","Tue Jun 6 09:11:39 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities are found to the S. mutans chromosomal genes.","Tue Jun 6 08:59:31 2006","","","","","","","13897496","Thu Jun 1 17:36:44 2006","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Tue Jun 6 09:01:58 2006","","7","","","","" "SMUpLM7_1","1417","1058","360","ATGCCGATGAGGTTTTTGCGAAGTATGAATTATAAAGTGAAATTTACCCAGCCAGCTATTGATGATTTAGATGATATTTATAATTATTACGAGACTGAACTTTCAAAATTATCTGCCGATAAAGTAATAAAGAGCCTAAGAGAAGCGACTAATTTACTAACTTTTTCACCAGAAGGCGGGATAGATTTCAATAAGAGAATTGGTCAAGAAGTTATTCAAGGACAATCTCTTAAAATGTTTGTAGCTCAGCAATACCTCATATTCTATATTGTAGTTCATTCAGAAGTCCGTATTATGCGAATTATCAGCACTAAAACAAATTATATGAACGAACTAGAAAATTTATTTAAGAATTTTAAA","","","14160","MPMRFLRSMNYKVKFTQPAIDDLDDIYNYYETELSKLSADKVIKSLREATNLLTFSPEGGIDFNKRIGQEVIQGQSLKMFVAQQYLIFYIVVHSEVRIMRIISTKTNYMNELENLFKNFK","1052","","hypothetical protein perhaps involved in plasmid stabilization","Cytoplasm","This sequence corresponds to GI:14602221 in GenBank. It is similar to orf5 in the S. mutans plasmid pUA140 but otherwise shows no similarity to the NR database.","

InterPro
IPR007712
Family

Plasmid stabilization system
PF05016	$\"[13-108]T$	Plasmid_stabil

","","","","","","","","","","","","","","","Tue Jun 6 09:08:29 2006","Tue Jun 6 09:08:29 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities are seen to the S. mutans chromosomal genes.","Tue Jun 6 09:08:29 2006","","","","","","","14578604","Thu Jun 1 17:30:20 2006","","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Tue Jun 6 09:40:38 2006","8","","","","" "SMUpLM7_2","2826","2407","420","ATGGCTAAAGTAATATTACTAACTTCAGATTATCAAAGAGACTACTCAGGAATTTTTCTAAATCCTTATGTTTATGGGGGTTCAGTTGAAACTTGTGCAATTGATAAAAACAATACTGTAAAATGCATTAATCTCAAATTTGGGAATAATTATGATATCAAATACTGTGTTATCGAGTTAAAAGATGGTAATTATGTCTATGGGAGTTATCATGATTTACTACCTAAAATTCAAAGTGGAGAGCTTAAGATTATATTTTCTGACCGTCCCCTTGGAGATGATGAAGAAGAATTTTGGAATTATGAAGAACTCCCATTAACAAGAATTTTCAATATGCGAGAAAGTTGGCTAGAAAATGAATCCTTATATAGAATTGTACAAATCATACAAGATATTGCTCGTCTAAAGATACCTCACAAA","","","16426","MAKVILLTSDYQRDYSGIFLNPYVYGGSVETCAIDKNNTVKCINLKFGNNYDIKYCVIELKDGNYVYGSYHDLLPKIQSGELKIIFSDRPLGDDEEEFWNYEELPLTRIFNMRESWLENESLYRIVQIIQDIARLKIPHK","2401","","hypothetical protein","Cytoplasm","This sequence corresponds to GI:14602222 in GenBank. It is similar to orf3 in the S. mutans plasmid pUA140 (GI:13937266) but otherwise shows no similaritiy to the NR database.","No hits reported.","","","","","","","","","","","","","","","Tue Jun 6 09:17:46 2006","Tue Jun 6 09:17:46 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities are found to S. mutans chromosomal genes.","Tue Jun 6 09:17:46 2006","","","","","","","14578605","Thu Jun 1 17:31:19 2006","","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Tue Jun 6 09:48:49 2006","8","","","","" "SMUpLM7_3","4506","2842","1665","ATGGACAACAATTTAGAAGAAACAATAGGTGCTAAAGAAGCGGAGATTACAGGTGAAATCTTTTTACTAATCAGTTTTCTTTTAGCACCGTTTGCAGGTTTCATTTCCATACTTTGTTATGGTCTTTCTCGCCTTTTATTGAATCAGCTAAAGGCAACCCTGTTGCTATTTTTTACTGGGGTAATCATGATTATTAGTTTAACCTTTTCAATAAGATTTCCTAATTTAAAGGATTTTCCTATTTTAAAAGCAATTCAAGATTATTTATTGTTTTTATTGGGAAAATCTCAAATAGAACCATCTTCTATCTTATCTCTTTGGTTTAAGAGCTTTAATTGGTATATATTAAGCATGACTATGATAACGCAAGGTTTTGGTCTTATACTGTTACCAAAAAGTCAAAAAGAAAAGCTAAAAGATGTTAGGAAAAAAGAAGAAAGGAAGCACTTATCTAGTCGAAAGAGCAGTAAAGTGCTTGATATGAGCAGTAAAAAACATCTTTTTACTGCAGGGACAACAGGTTCAGGGAAATCAGCAAATATTTTGCGTTATATTGATGATACCCTAAAAAATGATGGTTTTTCAGTCATCATTGATGGTAAAGGTGGACTTGGAGACTATGATTTAGCAACTGTTACACTAAAATTAGCTAAAAAATATAATAGGAAAGTCTATATTATCAATCAAACGGATGTAGAACAGACGAATGCTTACAATCCTTTCATGGGCTTATCTGCGACGCAAGTTAAAGATATGCTCATTAATATGAGTGACTGGGAAAGTGACCACTATAAGACATTATCAGCTCGATACTGGCAGGTTATGGTCGATGTGATGCTTAAATGTCATATCCCAATTAGTTTTGAAAGTCTCATTTATTTTTCGTTTAAAAAACATTTGTTAAGTTTGCTAGATGAAGCTATAAAGAAAGACCTAATTGAATCAGAACTATATCAGTTAGCAGAAAGTCTTGCTAATGGCGAAAGTGGCACACAAGCAGAAATATCTATTGCTAGAAGCGCTGTTGTTTATGAAGGGGATGGACAAAAATTATTTAGTAGCCAAAATGCTTTCAATATCAGCAAGGCATATGAGGAGAATGCCATTGTTTTAGTTTTATTAAACGAGTTTAATTATAGTGATTTTGCTCGTTCAACAGGGAAAATAGTTATTGATGATATTAAGAATCTTGTCGGACAGCTACAAAAAAAGCAACAGAATCATCAGTTAGACGGAAGAAAAATCCTATTTATTTTTGAAGAATTAGGAGTATATGTCGATATAGGTATAGAGGGGTTATTGAATAGAACAAGGTCGATTGGTGCTAAAGTCATCTGTTCAGTGCAAACAACGGCTGATATAGACCAAATTAGCCCAGAACTGACGCGTCAGATAATGGGGAATTGTAATGAATATATGATTATGCGAGTATCAGACCCAGACAGTGCAGAATTAATATCAAAAATGATCGGGACCAACAAAACAATCAAAAAAACATTTAGAACGAATGATAAAATTGAAACAGGTGACTCTAGTAATGTATTGACTGATAGTTTTAAAATTAGTCCAAATGAAATAAAGAACTTACCAGACCTCTTTGGGTTCTACTATTCAAAAAGTACCCCAAATAGCATTAAACGTTTTAAAACAGCATTTATTAAAATT","","","62653","MDNNLEETIGAKEAEITGEIFLLISFLLAPFAGFISILCYGLSRLLLNQLKATLLLFFTGVIMIISLTFSIRFPNLKDFPILKAIQDYLLFLLGKSQIEPSSILSLWFKSFNWYILSMTMITQGFGLILLPKSQKEKLKDVRKKEERKHLSSRKSSKVLDMSSKKHLFTAGTTGSGKSANILRYIDDTLKNDGFSVIIDGKGGLGDYDLATVTLKLAKKYNRKVYIINQTDVEQTNAYNPFMGLSATQVKDMLINMSDWESDHYKTLSARYWQVMVDVMLKCHIPISFESLIYFSFKKHLLSLLDEAIKKDLIESELYQLAESLANGESGTQAEISIARSAVVYEGDGQKLFSSQNAFNISKAYEENAIVLVLLNEFNYSDFARSTGKIVIDDIKNLVGQLQKKQQNHQLDGRKILFIFEELGVYVDIGIEGLLNRTRSIGAKVICSVQTTADIDQISPELTRQIMGNCNEYMIMRVSDPDSAELISKMIGTNKTIKKTFRTNDKIETGDSSNVLTDSFKISPNEIKNLPDLFGFYYSKSTPNSIKRFKTAFIKI","2836","","mob protein","Membrane, Cytoplasm","This sequence corresponds to GI:14602223 in GenBank. It is similar to orf2 from the S. mutans plasmid pUA140 (GI:13937267) and to numerous Mob-like proteins, e.g. GI:66947616 from Spiroplasma citri","

noIPR
unintegrated

unintegrated
G3DSA:3.40.50.300	$\"[134-537]T$	G3DSA:3.40.50.300
SSF52540	$\"[165-554]T$	SSF52540

","","","","","","","","","","","","","","","Tue Jun 6 09:24:51 2006","Tue Jun 6 09:45:15 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities are found to the S. mutans chromosomal genes.","Tue Jun 6 09:24:51 2006","","","","","","","14578606","Thu Jun 1 17:31:52 2006","","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Tue Jun 6 09:45:15 2006","8","","","","" "SMUpLM7_4","5267","4494","774","ATGGTCAGAGGTTTAAAAGAAATTGAATTGAATGATAGAGATCGGTTTGTGTTATATCTCTTGGATAAATTTAGGGTATTAGATGCTAAGAGTGTAGCTGTTATGGCTAGTTTTTCAAGTGAGTCTTATGCTGCTATTCGTTTGCAGAAATTAGCTCGTTATGGCTATATTAAGCGGGAAAGAATAGTTACCTCTCTTCCATTGGTTCATTATTTAACGTCAAAAGGTAATGATGAAATCAATGATATTAGGAGAAGACAAATTAAGCCAAGAATTGGAACACTAGAACACGAGCTAGCAGTAGGCAGAGTAGCCTCTTATTTAACTTTAAATAGAGGGATAGAGCCTATTTCTATGATAACAGACCGTGATATGCGAGCTTATGAAAGCCAGATAAATGACAATAGAGTCATGTCACGAAAAGGGGATATTGTCTTTTTATGTCCTAAAACTAATAAAAAAGTATTAGTAGAAGTTGAATTGACATTTAAAGGGGTCTCCAGAACCAAGGAAAATATTCGAAAGAATAAAAGAATATCAGATGAACAGCTCTGGTTTTATCCAAAACATAAAAAGGTTCTTGAAAAGGTTTTGAAGGAACAAAATATTGATAATAGATTTTATCTTGAAGATTTGTCTATTATTCCAGCTAATCAAACGATAGACTACCTCTTTCAAGATATAGATCGTTTTGAGAATATAGAATCATATTTCATAAATAACTTTATTGAACAACAAGGAGAAGGAGGTATTTTAGATAAATGGACAACAATT","","","30331","MVRGLKEIELNDRDRFVLYLLDKFRVLDAKSVAVMASFSSESYAAIRLQKLARYGYIKRERIVTSLPLVHYLTSKGNDEINDIRRRQIKPRIGTLEHELAVGRVASYLTLNRGIEPISMITDRDMRAYESQINDNRVMSRKGDIVFLCPKTNKKVLVEVELTFKGVSRTKENIRKNKRISDEQLWFYPKHKKVLEKVLKEQNIDNRFYLEDLSIIPANQTIDYLFQDIDRFENIESYFINNFIEQQGEGGILDKWTTI","4488","","rep protein","Cytoplasm","This sequence corresponds to GI:14602224 in GenBank. It is similar to the rep protein from S. mutans plasmid pUA140 (GI:13937268). Otherwise no similarities are found to the NR database at this time.","

noIPR
unintegrated

unintegrated
SSF46785	$\"[1-76]T$	SSF46785

","","","","","","","","","","","","","","","Tue Jun 6 09:35:25 2006","Tue Jun 6 09:35:25 2006","","","","yes","Fri Feb 20 15:41:32 MST 1998","No similarities are noted to the S.mutans chromosomal genes.","Tue Jun 6 09:35:25 2006","","","","","","","14578607","Thu Jun 1 17:32:26 2006","","Zou X, Caufield PW, Li Y, Qi F, Zhou X.Complete nucleotide sequence and characterization of pUA140, a cryptic plasmid from Streptococcus mutans.Plasmid. 2001 Sep;46(2):77-85.PMID: 11591133","","Tue Jun 6 09:42:21 2006","8","","","","" "SMu0889","923353","924027","675","ATGGTCGGAGAGTTATCGCGTGTTTATGTTGATCTTGATAGCGAAGAAATTGATCTGGTTCTTGAAATTATTCATCAAGGGCAAGAAAAGTTAGGACAAACCTTTGATATTTCCCTTTATATTGCCTTGGCTGACCACCTTCATTATACTATCCAAAGAACCAGAGAAGGTCTTACCTTACAAAATCCTCTTGCTTGGGAAGTCAGAAAGTTTTATCCTGAGGAGTTCCAATTAGGAAAAGATACGATTGAATTGGTCAAAGAAAAAATGACGCTTCAATTGGCAGATGATGAAGCGGCTTCTATTGCCTTGCATTTTATTAATGCGCAAAAAGATGGTGGCCTATTAGAAAAGAATCGCCTTATTTCTAAAATTGTTAGTGATATTTTAGAAATTGTTCGTTTGCATTTTGGGGAGGTTAGAGATGAAGAATCAATCAGTTATAATCGGTTTATCACCCATGTTCAATACTTTGCTCAACGTGTAGCTAATGGTCTTGTTCAAGGAAAAAATGACGCTTTTCTTTATGAACAGGTCAAAGAAAATTATCCTCATGCCTTTGCTTGCACAGAAAAAATTAAATCTTATGTAGAATCTGCTTATAATTTTGCTATGAGTAGAGATGAGCAGGTTTACCTGACCATCCATATTCAACGTCTAGAGACTAGTCAATAA","5.16","-11.13","25943","MVGELSRVYVDLDSEEIDLVLEIIHQGQEKLGQTFDISLYIALADHLHYTIQRTREGLTLQNPLAWEVRKFYPEEFQLGKDTIELVKEKMTLQLADDEAASIALHFINAQKDGGLLEKNRLISKIVSDILEIVRLHFGEVRDEESISYNRFITHVQYFAQRVANGLVQGKNDAFLYEQVKENYPHAFACTEKIKSYVESAYNFAMSRDEQVYLTIHIQRLETSQ$","","","transcription antiterminator (BglG family) - fragment","","","

InterPro
IPR011608
Domain

PRD
PF00874	$\"[21-109]T$ $\"[123-220]T$	PRD

noIPR
unintegrated

unintegrated
G3DSA:1.10.1790.10	$\"[2-113]T$ $\"[115-224]T$	G3DSA:1.10.1790.10
SSF63520	$\"[10-111]T$ $\"[116-222]T$	SSF63520

","No hits to the COGs database.","***** IPB001550 (Transcriptional antiterminator bglG) with a combined E-value of 2.7e-24. IPB001550A 12-27 IPB001550B 40-74 IPB001550C 91-109***** IPB004341 (CAT RNA binding domain) with a combined E-value of 1.5e-22. IPB004341B 71-109 IPB004341C 148-157 IPB004341B 182-220***** IPB011608 (PRD) with a combined E-value of 1.2e-12. IPB011608B 62-105 IPB011608B 173-216 IPB011608B 3-46","Residues 17-220 are similar to a (TRANSCRIPTION ANTITERMINATOR) protein domain (PD735577) which is seen in Q88T56_LACPL.Residues 122-224 are similar to a (ANTITERMINATOR TRANSCRIPTION FAMILY TRANSCRIPTIONAL OPERON BGLG BETA-GLUCOSIDE REGULATION ANTITERMINATOR LICT) protein domain (PD858308) which is seen in Q8DUF3_STRMU.Residues 45-112 are 61% similar to a (TRANSCRIPTION ANTITERMINATOR SIMILAR LICT) protein domain (PDA1F2F2) which is seen in Q6AB16_PROAC.Residues 112-162 are 70% similar to a (ANTITERMINATOR TRANSCRIPTION BETA-GLUCOSIDE OPERON TRANSCRIPTIONAL BGLG FAMILY ANTITERMINATOR LICT BGLR) protein domain (PD456196) which is seen in Q928K2_LISIN.Residues 122-224 are similar to a (ANTITERMINATOR TRANSCRIPTION FAMILY TRANSCRIPTIONAL OPERON BGLG BETA-GLUCOSIDE REGULATION ANTITERMINATOR LICT) protein domain (PD858308) which is seen in Q8DUF3_STRMU.Residues 171-220 are 78% similar to a (ANTITERMINATOR TRANSCRIPTION OPERON BETA-GLUCOSIDE BGL REGULATION TRANSCRIPTIONAL BGLG FAMILY LICT) protein domain (PD212919) which is seen in Q6HMK4_BACHK.","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:06:23 2007","Tue Nov 20 13:22:02 2007","Tue Nov 20 13:22:02 2007","Tue Nov 20 13:06:23 2007","Tue Nov 20 13:06:23 2007","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:06:51 2007","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:19:30 2007","Tue Nov 20 13:22:02 2007","Tue Nov 20 13:22:02 2007","yes","Fri Feb 20 15:41:32 MST 1998","","Tue Nov 20 13:05:12 2007","Tue Nov 20 13:05:12 2007","","","","Residues 21 to 109 (E_value = 5e-16) place SMu0889 in the PRD family which is described as PRD domain.Residues 123 to 220 (E_value = 1.5e-15) place SMu0889 in the PRD family which is described as PRD domain.","Tue Nov 20 13:05:12 2007","","","","","","","1","Tue Nov 20 13:05:12 2007","","","" "SMu0964","1001046","1001165","120","ATGAGACGTTCTCTAGGCAATAGTGCTTCTTTTGCAGAATGGATTGAATACATAAGATACCTCCACTATATTATTCGTGTTCAATTCATTCATTTCTTTTCAAAAAATAAAAAGATTTAG","","","","MRRSLGNSASFAEWIEYIRYLHYIIRVQFIHFFSKNKKI","","","hypothetical protein","","","","","","","","","","","","","","","","","","","","","","","yes","Fri Feb 20 15:41:32 MST 1998","","","","","","","","","","","","","","","1","","","SMU_1056",""