Prevotella intermedia
(HMT-643)
Taxon Description:
Disease Associations:
Although commonly detected in subgingival plaque P. intermedia has been associated with periodontal disease [2] aggressive periodontitis necrotizing ulcerative periondontis endodontic infections [4] and facial gangrene (noma) [5]. Has also been linked to coronary artery disease [3].
Prevalence and Source:
Primarily colonizes the gingival crevice but also found in head neck abdominal and lung infections. Has been isolated from blood.
Formerly known as Bacteroides melaninogenicus subsp. intermedius and then Bacteroides intermedius. Phylogenetic analysis based on 16S rRNA sequence comparisons and biochemical characteristics warranted separate genus designation to the genus Prevotella i.e. Prevotella intermedia [1].
Disease Associations:
Although commonly detected in subgingival plaque P. intermedia has been associated with periodontal disease [2] aggressive periodontitis necrotizing ulcerative periondontis endodontic infections [4] and facial gangrene (noma) [5]. Has also been linked to coronary artery disease [3].
Prevalence and Source:
Primarily colonizes the gingival crevice but also found in head neck abdominal and lung infections. Has been isolated from blood.
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References:
[1] Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998 Feb;25(2):134-44
[2] Gomes BP, Jacinto RC, Pinheiro ET, Sousa EL, Zaia AA, Ferraz CC, Souza-Filho FJ. Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella intermedia and Prevotella nigrescens in endodontic lesions detected by culture and by PCR. Oral Microbiol Immunol. 2005 Aug;20(4):211-5
[3] Enwonwu CO, Falkler WA, Idigbe EO. Oro-facial gangrene (noma/cancrum oris): pathogenetic mechanisms. Crit Rev Oral Biol Med. 2000;11(2):159-71
[4] Nonnenmacher C, Stelzel M, Susin C, Sattler AM, Schaefer JR, Maisch B, Mutters R, Flores-de-Jacoby L. Periodontal microbiota in patients with coronary artery disease measured by real-time polymerase chain reaction: a case-control study. J Periodontol. 2007 Sep;78(9):1724-30
[5] Shah HN, Collins DM. Prevotella, a new genus to include Bacteroides melaninogenicus and related species formerly classified in the genus Bacteroides. Int J Syst Bacteriol. 1990 Apr;40(2):205-8
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